Dragon09/odtu_chatbot huggingface dataset:
optimizing passenger experience in public transport

the current global climate crisis and ongoing shift towards autonomous transport necessitate sustainable and passengercentric public transport solutions the goal of optipex is to enhance of sense of comfort and safety of the passengers as well as the security and ease of travelling by cocreating ethical and passengeraware public transport services together with specific target user groups such as wheelchair users passengers with large objects fragile passengers with limited mobility tourists and students to achieve this optipex is built on three fundamental development pillars measurement analytics and interaction optipex partners will develop perception technologies to measure passenger behaviour and situations trustworthy analytics is essential in recognising realtime passenger experiences and situations enabling interaction with services and vehicles moreover optipex partners will develop adaptive and interactive vehicle technologies and digital services in collaboration with target groups and suitable for various public transport modes these services will optimise the onboard experience promoting safety inclusiveness and trust ultimately improved passenger satisfaction will drive the adoption of automated public transport technologies and improve the sustainability of mobility services via contribution to the modal shifta consortium consisting of 3 research organisations 6 industry members and 2 smes will validate the developed solutions together with target groups and other stakeholders in three living labs the consortium has leading expertise in human behaviour usercentric design vehicle technologies modelling and data analysis and adaptive and interactive services the successful adoption of optipex results will be facilitated by efficient dissemination communication and exploitation activities in collaboration with the connected cooperative and automated mobility ccam partnership
rephase redox regulation of phase separation for plant adaptation to stressful environments

the proposed project explores the intriguing possibility of reactive oxygen species ros regulating the formation of stress granules sgs during heat stress heat stress triggers the rapid accumulation of ros with h2o2 playing a pivotal role as a signalling molecule that induces oxidative posttranslational modifications oxiptms to regulate protein activities on the other hand an increase in temperature leads to the formation of enigmatic droplets in the cytosol known as sgs these membraneless organelles mlos arise through liquidliquid phase separation llps enabling the concentration of proteins mrna and metabolites to facilitate cellular adaptation ros accumulation and sgs formation have traditionally been viewed as independent events in the heat stress response however recent studies have shed light on the significance of oxiptms as regulators of protein llps in plantsmoreover my preliminary experiments have demonstrated that the chemical blocking of oxiptms impairs sg formation during heat stress i propose that ros accumulation during heat stress induces oxiptms on proteins promoting llps and facilitating sg formation the rephase project aims to address this hypothesis through two main objectives firstly i will investigate the dynamics of the redox state within sgs during heat stress secondly i will map the landscape of oxiptms in sgs shedding light on their distribution and functional implications to achieve these goals the fluorescent redox biosensor rogfp2orp1 and the proteomic oxitrap probe yap1 will be targeted to sgs utilizing these innovative methods will enable a comprehensive exploration of the redox biology of sgs leveraging the stateoftheart proteomic core and live cell imaging facilities available at the host institute by bridging the gap between redox signalling and sgs the rephase project promises to provide valuable insights into the mechanisms underlying plant adaptation to environmental stress
senolytics repurposing in childhood refractory epilepsies

epilepsy is a frequent neurological disorder characterized by recurrent seizures resulting from hyperexcitability and hypersynchrony of neuronal networks cortical malformations including focal cortical dysplasia fcd are rare sporadic diseases that cause earlylife drugresistant seizures for which surgery is the only therapeutic option to control seizures surgical inaccessibility and failures are significant clinical drawbacks this emphasizes a critical and urgent need for new precisionbased therapies for this debilitating childhood disorder in recent years my team contributed to revealing that fcd are caused by brain somatic mutations in genes belonging to the mtor pathway a signaling cascade regulating key physiological cell functions such as growth proliferation and metabolism during the course of my ercfunded project we discovered specific biomarkers in both human and mouse preclinical fcd brain tissues in episen we propose an innovative pharmacological strategy based on the selective elimination of mutated cells by repurposing available molecules that are currently used in clinical trials in other diseases for fcdrelated epilepsy we hypothesize that abnormal cells once acutely cleared will offer a prolonged benefit on seizures direct users include applied research groups pharma companies the medical community for clinical trials and patient associations
impurities in the microstructure of eemian greenlandic ice via laser ablation

deep ice cores from ice sheets are unique climate archives chemical impurities deposited initially on the ice sheets are used to reconstruct the climate of the past despite being investigated for several decades the processes affecting impurities after their deposition ie in the microstructure of ice still need to be clarified especially in the oldest parts of the cores while the quest for the oldest ice in antarctica has just started many open questions remain before analysing ice up to 15 myr old the mesmerise project aims at investigating the oldest sections of the ngrip neem and recap ice cores from greenland which reach back to the last interglacial the eemian and thus enable important insights into the conditions of a warmer world in ngrip ice annual layers and impurities seem unaffected by relocation diffusion and deformational processes mesmerise will test this hypothesis by comparing chemical impurities in holocene and eemian ice using two stateoftheart laser ablation inductively coupled plasma mass spectrometry laicpms 2d imaging systems the recent refinement of the laicpms technique by assist prof pascal bohleber at the university of venice enables the analysis of impurities in ice in ultrahigh resolution and two dimensions it is thus the most promising tool to distinguish annual layers and the localisation of different chemical elements in the microstructure of deep polar ice to investigate postdepositional processes affecting the climate signal assist prof bohleber and assoc prof anders svensson an ice core analysis expert from the center for physics of ice climate and earth at the university of copenhagen denmark guarantee highquality research and education at the host institutions mesmerise will further build a bridge between the two erc projects aice and green2ice and thus benefits from possibilities such as applying machine learning and modelling to experimental and observational data
opera fandom in the digital age

today interactions between audiences and theatres occur to a significant extent via online platforms and digital media opanda studies the impact of these transformative technologies on opera fandom although recent research has addressed the digital dissemination of opera the phenomenon of cyberfandom remains underresearched situated at the intersection of musicology sociology and media studies the project asks how opera fans perform their passion digitally this entails the investigation of their interactions on the web but the project also considers how cyberfandom intersects with traditional fan behaviour in a postpandemic and hypermediatised society in which the divide between stage and screen is constantly blurred the project reconsiders past audience practices and envisions possible future onesopanda aims at providing a pioneering study of todays opera fans ie the most active operagoers including their digital practices and communities to reach this goal opanda is based on a comparative and qualitative analysis of representative case studies combining digital ethnography on web communities and fanzines participant observation at opera companies la scala paris opera the new york metropolitan opera and interviews with fans dr nicol palazzetti researcher is well placed to carry out this research thanks to an outstanding background in musicology and sociology and a solid expertise in performing ethnography among opera fans by situating his project at sapienza university of rome he advances his career in new directions he has the key opportunity to work with prof emanuele senici supervisor a prominent opera scholar specialising in opera and media and with prof romana and cosupervisor an expert in fan studies a trainingbased secondment at the digital ethnography research centre in melbourne and a disseminationbased secondment at the music department of yale university support the achievement of the project
oxygen optimization therapy through bcpap for management of childhood pneumonia in general hospitals of lmics

pneumonia is a leading cause of morbidity and mortality especially among children in subsaharan africa nigeria and ethiopia are among the 5 countries that account for half of the underfive pneumonia deaths majority of the deaths from pneumonia are however preventable with early diagnosis and appropriate management in children with pneumonia hypoxemia is quite common and constitutes a major risk factor for death the who and other leading child health agencies urge widespread access to oxygen therapy bubble continuous positive airway pressure bcpap is a method of delivering oxygen and positive pressure into the airways thus keeping the alveoli open for improved gas exchange while use of bcpap devices appears safe and effective worldwide scaling of quality bcpap devices in low and middleincome countries lmics has been limited this has prevented most children in lmics from receiving lifesaving noninvasive respiratory support which could have saved many lives achieving sustainable development goal sdg 32 of the reduction of under5 mortality to at least as low as 25 per 1000 live births by 2030 will likely not be possible without access to innovative and low cost interventions devices such as bcpap in lmics the aim of the optbcpap is to perform contextappropriate scaleup of bcpap in settings of very high disease burden nigeria ethiopia and malawi using the the positive results and the lessons learned from clinical trials conducted in ethiopia bangladesh and ghana in addition to scaling up bcpap we will deeply explore additional factors associated with treatment failure and mortality from severe pneumonia we aim to generate data on adherence to treatment guidelines healthcareseeking behaviour magnitude of respiratory syncytial virus infection antimicrobial resistance pkpd of commonly used antibiotics and generate novel recommendations for antibiotic treatments tailored to the populations in these diverse settings
understanding the interaction of t cells and immune complexes in systemic lupus erythematosus

systemic lupus erythematosus sle is an autoimmune disease with a complex pathogenesis immune complexes ics are formed and deposited in various tissues leading to inflammation and damage t cells are part of the adaptive immune system but also express innatelike receptors that could interact with ics by binding complement factors or the constant region of immunoglobulins however the extent of these interactions and there relevance for the sle pathogenesis has not been investigated so far in the ticisle project we will analyze these interactions by 1 investigating the expression of receptors that could interact with ics on t cells in the blood and inflamed tissue of sle patients 2 cultivating t cells with immune complexes and antibodies stimulating or blocking individual receptors thereby elucidating the consequences of these interactions and 3 analyzing spatial t cellic interactions and their secondary consequences like proinflammatory changes in stromal cells and chemoattraction of inflammatory cells in skin samples from sle patients we hypothesize that t cellic interactions result in costimulation of t cells leading to production of proinflammatory cytokines cytotoxicity and induction of an inflammatory microenviornment understanding these interactions can then be exploited by the future development of therapeutics targeting these interactions an additional focus of the project will be the personal development of the applicant and the dissemination and exploitation of project results
dissecting the impact of epithelial stem cell niches on oral cancer heterogeneity

the oral epithelium is a unique tissue with a high degree of structural heterogeneity and distinct microenvironments niches however the molecular mechanisms underlying the sitespecific proliferation and differentiation of oral epithelial stem cells oescs remain poorly understood oral squamous cell carcinoma oscc one of the most common oral cancers is a heterogeneous cancer type occurrences of metastatic lesions and treatment response differ from oral site to site indicating a causal link to the heterogeneous nature of distinct oesc pools in the oralniche project we will for the first time systematically and comprehensively characterise the oesc pools dissect key mechanisms underlying oral epithelial sitespecificity and define their contribution to oscc heterogeneity to achieve this we will combine novel mouse models and patient material with cuttingedge methodology including whole mount imaging singlecell sequencing and organoids initially we will profile the proliferative activities of oescs and explore how stemness is regulated within defined niches in homeostasis oscc and chemotherapyinduced mucositis subsequently we will functionally assess cellular cues that modulate stemness in the oral epithelia and generate a comprehensive singlecell atlas of oescs and their cellular niches lastly using oscc patient material we will validate key observations to define potential new biomarkers and therapeutic targets in summary this multidisciplinary approach will reveal how the distinct oesc pools maintain homeostasis and how they respond to challenges such as mucositis and oscc oralniche will deliver new knowledge on the impact of tissue sitespecificity on tumour heterogeneity and therapy response which will have significant implications for oscc patients moreover the knowledge gained and the technological advances proposed will be applicable to other tissues and tumour types and thus provide a model approach in cancer research
secure hardware with advanced nonvolatile memories

over the recent years the explosive growth of digital technologies allowed to implement disruptive business models driven by data collection and processing in particular the internet of things iot opens unprecedented opportunities for consumers smart society organisationscompanies industry 40 smart factories and governments smart nations however as every adoption of new technologies involves some risks security attacks are amongst the most severe challenges for iot only in 2021 the inflicted damages have been valued 6 trillion globally and 1097 organizations were hit by ransomware attacks secure iot is generally enabled by the physical unclonable function puf namely a hardware function which is embedded in the chip and capable of generating a random unique response to a given challenge improvements in attack methods over the years have recently moved the field of pufs from the conventional siliconbased cmos technology toward emerging nonvolatile memories nvms the latter allows for high density low cost highly scalable puf with the capability of reconfiguration currently a truly tamperresistant and reliable weak puf leveraging stochastic switching of nvms for secure iot is still missing and highly requested by the market within the erccog project rescue 20152020 a novel method for true random number generation trng based on nvms was developed and patented the trng scheme allows for ipuf invisible puf namely a digital highly reliable puf which is 100 robust to physical attacks within the shannon project we will address the technical and commercial feasibility of ipuf validating the concept with industry grade embedded nvms and elevating its technology readiness level via experimental tests and simulations new architecture and algorithms will be developed to strengthen the ip position of ipuf as a scalable security primitive for iot systems
a paneuropean network of genderconscious investors to support femaleled companies for growth and sustainability

european innovation performance continues to increase yet inequalities particularly in access to investment are still noteworthy there is a need to close the performance gaps which are still visible between strong innovators north and west eu and moderate and emerging innovators south and east eu mostly a major asset to successful and sustainable business growth relies upon awareness and strong communication between innovative sectors and investors on available resources their access and interventions by publicprivate funders improving networking between innovation ecosystems is key to the success of growing businesses and driving continued economic developmenther funds ambition is to foster knowledgesharing and synergies between innovation actors existing initiativesprojects in order to support the next generation of startups with an emphasis on womenled companies and genderconscious investors these interactions will notably lead to best practices identification capacitybuilding activities and guidelines strengthening and broadening an interregional collaboration hub will promote a more competitive eu and a more sustainable inclusive diverse and resilient worldthis will be done in a communitydriven crossfunctional crosssectoral multiplier based way with partners bringing together communities of experts from different deeptech sectors from around europe and beyond her fund will 1 transform less connected territories into recognized and attractive innovation valleys that pool and reward investments 2 create bridges between eu innovation ecosystems increasing access to capital and investment in less connected innovation ecosystems and allowing local startups benefiting from foreign investments 3 raise the number of gender conscious investors in europe for support to womenled companies 4 boost women entrepreneurship especially in moderate and emerging innovators offering them access to more funding opportunities
sectorcoupling hub for circular use of thermal and industrial waste

within hurricane a sectorcoupling circular hub centered around the arcelormittal ghent site will be created we will target efficient resource management together with the recovery and utilization of squandered industrial waste heat and water together with arcelormittal ghents ongoing initiatives this will lead to a reduction of energy water and raw materials by at least 20thanks to the ongoing projects taking place within and around the ghent site the site is already well connected to many other industries like waste suppliers chemical producers ethanol offtake h2 waste gas renewable power producers and wastewater treatment it has become a multisectoral hub leading to efficient implementation of industrial symbiosis concepts the ghent site has a significant amount of recyclable energy material and water that allows this symbiosis these aspects are not only from the steel making processes but also from other operations taking place in the mentioned multisectoral hub this hub can be further enhanced with the integration of waste heat with its ongoing initiativesour solution aims at developing and demonstrating novel heat recovery heat exchanger and upgrading heat pumps solutions from selected operations and then coupling it with the internal and external off takers by means of a heat grid with digital tools aspects like broadening the district heating network and adapting the heat demand profile of the buildings to better match the intermittent of the waste heat can be optimized finally an integrated software tool for circular hubs that combines the different tools and data produced at the different operations will be developed and validated through two virtual demonstrations and a circular hubs blueprint the replication potential will be proven the consortium is formed by 12 partners from 5 different countries including 4 research organizations 1 large end user 3 smes and 3 civil organizations and 1 linked 3rd party
selffoldable origamiarchitected metamaterials

technological progress and increasingly environmentalrelated problems call for new cuttingedge design strategies to improve materials functionalities the sfoams challenge is to breakthrough metamaterial design by implanting origamikirigami capabilities within architected cellular structures at different scales thus bringing metamaterials to unprecedented mechanical performance the resulting metamaterials will combine multistability anisotropy geometrical frustration control of localized deformation and ellipticity loss to achieve a new capability selffoldability and shapemorphing induced by external stimuli unlike what happens in currently available origami the location of the creases is not a priori imposed but selfguided by ellipticity loss occurring in the homogenized material equivalent to the kirigamiorigami and selfcontrolled by embedding within the microstructure topological point and line defects this introduces an unexplored field of research in which a material element will become able to mechanically react to actions from the surroundings through a direct change in its shape thus reaching a configuration that optimizes its stiffness strength toughness and in a word its environmental resilience the research project sfoam will develop modelling based on the mechanics of solids and structures numerical simulations and experimental tools for the optimal design of origamikirigamilattice metamaterials applications are envisaged in soft robotics where grippers grasp and manipulate objects without damaging them and in wearable devices where materials gently adapt to humans movements moreover the design principle provided by sfoam is of great interest in developing adaptive medical devices and in maximizing solar power intake through flexible pvs integrated into metamaterials capable of changing shape depending on the sun motion