Dragon09/odtu_chatbot huggingface dataset:
monitoring of oceanic internal tides using fibre optic telecommunication cables

ocean mixing plays a crucial role in the earths climate as it balances the meridional overturning circulation that buffers global warming quantifying mixing is challenging because energy enters the ocean at basinscale but it dissipates at cmscale over the vast ocean one common element in the cascade of energy towards small scales is the transfer of energy to internal waves which ultimately drive ocean mixing energy transfers to the internal wave field are largely enhanced through flow interactions with topography observations of wavetopographic interactions are however scarce and its mechanistic understanding comes mainly from idealized process ocean studies which lack a direct benchmark against nature to fill the observational gap in ocean mixing the mooring project will explore wavetopographic interactions at unprecedented spatiotemporal resolution by combining novel submarine cable data with numerical advanced modelling new data will be gathered using fibreoptic cables by means of a revolutionary technology which has opened a new door for exploring bottom wave dynamics the potential of these novel observations to identify oceanmixing hotspots in the ocean remains however unknown to shed light on this i will gather conventional oceanographic measurements and integrate them in realistic highresolution numerical simulations leveraging my modelling skills the mooring project will bridge seismology and oceanography integrating a variety of approaches and it will allow me to be trained in observational methods at the hosting institution while expanding my numerical skills in a secondment institution fostering a network of national and international collaborators the proposed approach could eventually be implemented at global scale with the aim to better close energy budgets and improve mixing parametrizations in climate change models for more accurate predictions
characterisation and design of rnalipid interactions for rna therapeutics

rna is a ubiquitous biomolecule with a broad range of activities crucial for keeping cells alive understanding how rna bioactivity is controlled is vital for elucidating its roles and applications in molecular biology rna in order to maintain a correct activity patterns has to be organized despite sufficient knowledge about rna spatial organization within cells via rnaprotein interactionbased processes not much is known about other mechanisms revealing the rnalocalization patterns without rnabinding proteins would create the new branch of interactomics which might have significant implications in the molecular biology and rnabased therapeutics developmentrecently i described that lipid membranes can act as a scaffold for rnas in a sequence and structure dependent binding process leading to the changes of the rna activity in vitro here i propose that lipid membranes act as a selective rna scaffold in vivo in the following project i will develop a library of membranebinding rnas using in vitro selection approach i will characterize the mechanisms selectivity and stability of rnalipid binding in bulk and in nanoscale level using selfdeveloped binding assays and superresolution microscopy respectively furthermore obtained lipidbinding rnas are going to be artificially introduced to the existing mrnas in order to spatially organize protein expression both in vitro and in vivo the rna rnalipid encapsulation efficiency will be characterized using recently developed singleparticle profiling platform lastly i will use gathered knowledge to livetrack the uptake and improve the rnabased therapeutics ie rnalipid nanoparticles in order to increase the rna stability and decrease the toxicity of the formulation
protecting the european territory from organised environmental crime through intelligent threat detection tools

perivallon aims to provide an improved and comprehensive intelligence picture of organised environmental crime and develop effective and efficient tools and solutions for detecting and preventing such types of criminal activities and for assessing their environmental impact based on geospatial intelligence remote sensing scanning online monitoring analysis correlation risk assessment and predictive analytics technologies by leveraging the latest advancements in artificial intelligence ai in the fields of computer vision and multimodal analytics as a result enhanced investigation processes and methodologies will be derived through the capabilities provided by the developed tools and solutions and the insights obtained though the proposed environmental crime observatory the capacity of end users including police authorities and border guards will also be improved and will enable them to tackle such criminal activities in an effective manner based on advanced tools and solutions and also on the innovative training curricula developed using physical andor digital twins of relevant environmental crime scenarios moreover improved international cooperation will be facilitated through improved data sharing enabled by blockchain technologies while improved regulation shaping and tuning will be supported through relevant policy recommendations perivallon will be validated in field tests and demonstrations in four operational use cases extensive training handson experience joint exercises and training material will boost the uptake of perivallon tools and technologies with a consortium 5 police and border guard authorities 3 authorities related to environmental protection 6 researchacademic institutions 8 industry partners including seven smes one eu agency and one foundation perivallon delivers a strong representation of the challenges requirements and tools to meet its objectives
systems materials engineering for highrate bulk solidstate conversion in metalsulfur batteries

batteries will be key in our efforts to reduce co2 emissions but require major progress in sustainability cost and energy density liquidelectrolyte metalsulfur batteries would be gamechangers in many respects a theoretical capacity amongst the highest of all batteries paired with the low cost and sustainability of sulfur however intrinsic obstacles are imposed by the electronically and ionically insulating nature of sulfur converting sulfur during dischargecharge is fundamentally different from mixedconducting storage materials while liion battery materials transform in the solidstate sulfur converts to metal sulfides in a solidliquidsolid process this causes poor cycle life and insufficient energy densitiesin this project we approach the fundamental challenge of sulfur phase transformation in a novel way highrate conversion in the bulk solidstate we will pioneer advanced metrologies such as cryoelectron microscopy and in situ grazing incidence scattering with stochastic modeling to quantify the phase evolution during electrochemical sulfur conversion at atomic and mesoscopic 11000 nm length scales based on systematic experiments on 2d transition metal carbide mxene substrates we will establish the scientific foundations of solidliquidsolid and solidstate sulfur phase transformation finally we will form cathodes as artificial solid mixed conductors by structuring sulfides and mxenes to enable highrate bulk solidstate sulfur conversion this will solve the cycle life issue of mes batteries and boost the stored energy by maximizing the sulfur packing densityfoundation of solidcon is a systems materials engineering approach identifying how mutual structuring of storage materials electron conductors and ion conductors defines the physicochemical processes across length scales electron ion and mass transport and electrochemical conversion
the coldchain challenge la carte timetemperature indicators enabled by patterned structural colour in organic semiconductors

the global demand for coldchain logistics is surging driven by changing consumer lifestyles government legislations to reduce waste and rapid diversification of supply chains the pressure is particularly felt in the pharmaceutical and medical industries where many lifesaving products such as vaccines peptides blood and plasma explicitly require shipping and handling at specific temperatures the use of timetemperature indicators to provide visual cues for undesirable exposure to elevated temperatures offers the means for coldchain verification however the existing food market indicators cannot fully address the specific challenges posed by the pharmaceutical industry such asi small size and flexible form factorsii low cost for itemlevel applications and distribution in lowincome countriesiii operation at ultralow temperatures from 20 down to 70 c for mrna vaccinesthe ambition of veritascan is to advance a new class of timetemperature indicators drawing on emerging smart packaging concepts and harnessing recent breakthroughs in scalable microprocessing of organic semiconductors realised within my group specifically my team will deliver versatile indicators design based on patterned organic semiconductor films that are erasable ondemand by selection of molecular solvents we will optimize the temperature range and accumulative exposure monitoring as well as validate the commercial viability of the technology via comprehensive fieldtests with our industrial partnersmy interim objective is to establish a sustainable value creation model in the market the longterm goal of veritascan is to introduce transformative usercentred technology that addresses urgent societal needs
phenomenological implications of neutrino effective theories

there are few but strong indications that the standard model of particle physics cannot be the ultimate theory of nature the increasing number of proposed extensions together with the lack of new particles found by the lhc is prompting us to consider the effective field theories eft as the best framework to explore deviations from the standard model nevertheless the most commonly explored eft framework does not consider the existence of new light particles such as those predicted by many theories trying to explain the origin of neutrino masses or dark matter and therefore cannot account for two of the biggest unsolved problems in particle physicsconsidering the existence of new sterile neutrinos for definiteness this project aims at building a new eft framework where additional light particles are included to the commonly used eft formalism first it will extend the few available works in the subject to construct a theoretically consistent framework in the second part it will make use of this formalism to identify and compute the most relevant predictions for the nearfuture experimental landscape
terahertz graphene receiver for wireless communications

6th generation 6g mobile broadband communications will transform the communications industry leading to high speed networks capable of linking integrated communication sensing and computing capabilities to fuse the physical biological and cyber worlds however 6g infrastructure will require a significant increase in data transfer rate 10 times larger than current standards ultralow power consumption 1pjbit and high reliability 5g technology originally designed for data rates up to 20 gbps cannot fulfill these requirements the subthz spectrum 100ghz300ghz could provide the required capacity for 6g shortrange wireless links on the other hand multipleinputmultipleoutput mimo systems consisting of multiple transmittingreceiving antennas are a key element of 5g tech dramatically increasing the spectral efficiency of the wireless link multiplying the data transfer rate of the single txrx antenna system by the number of implemented channels developing a technology that can combine the advantages of the subthz spectrum and mimo systems could yield shortrange 6g wireless connectivity significantly enhancing data rates power consumption and reliability icfos patented antennaintegratedgraphenethzdetector agtd technology providing ultrabroadband frequency operation high speed potentially 100ghz high sensitivity small footprint and low power consumption represents an ideal solution able to meet all the requirements for the realization of a mimo system operating at unprecedented frequencies teracomm envisions the realization and the demonstration of the receiver module of a graphenebased wireless mimo system able to reach data rates 100gbps for short range applications industrial links protection of intellectual property and commercial exploitation will lie at the heart of the project from the outset in order to maximize the potential for this technology to realize a significant social and economic impact
actionable metabolite supplements to improve treatment response in pancreatic cancer

the prognosis with metastatic pancreatic ductal adenocarcinoma pdac is simply terrible especially for those that do not respond to the chemotherapy which is regarded as the standard therapy in most patients more than half of the patients are nonresponders and eventually pass away within months it is therefore urgently needed to understand the differences among responder and nonresponder patients to develop alternative therapies that overcome the resistance and potentially further extend the survival for both groups a recent hypothesis proposes the key role of microbiome and of the immune response in regard to tumor initiation progression as well as response to therapies diet as a variable introduces an additional layer of complexity given its multifaceted impact on both the human microbiome and immune system as our recent manuscript show the metabolites produced by gut microbiota are influenced not only by diet but also by a host of other factors in actpc we propose the use of one or a combination of different microbiotaderived metabolites as a treatment to increase the efficacy of chemotherapy and at the same time to boost anti tumor immunity for pdac patients the overall goal of actpc is to initiate the preclinical validation of specific microbiotaderived metabolites for improving treatment outcomes in pdac patients this project is designed to take our technology readiness level from 2 to 4 enabling us to finalise the preclinical development within a subsequent eic transition and initiate clinical validation and development soon after in implementing the projects results we will leverage the pis unique network that includes commercial partners and patient organisations
hype assessing the central influence of hyperarousal in shaping trauma outcomes

up to 70 of people will experience a traumatic event in their lives following such events posttraumatic stress disorder ptsd emerges as the most common adverse psychological consequence affecting 1015 of survivors despite available therapies nearly 40 of patients continue to exhibit hyperarousal symptoms such as irritability risktaking behaviors sleep disturbances concentration difficulties and an enhanced startle response several cognitive processes eg attentional biases emotion recognition executive functioning have been investigated to understand the mechanisms behind isolated hyperarousal symptoms such as hypervigilance or startle responses however the exact nature and mechanisms through which these cognitive processes influence the whole spectrum of hyperarousal symptoms remain largely unknown in response the hype project aims to 1 offer the first comprehensive evaluation of the cognitive processes underlying various hyperarousal symptoms 2 examine the effects of gender and repeated traumatization on these processes and 3 longitudinally assess the predictive value of these cognitive processes on the development and persistence of other ptsd symptoms by utilizing eyetracking et electroencephalography eeg and machine learning techniques these studies will provide precise and reliable assessments of these intricate cognitive processes and highlight new therapeutic targets with direct benefits for patients while both the hostlab and myself are specialized in ptsd the synergy between the host labs expertise in eeg and affective neurosciences and my knowledge of et and advanced statistical methods makes this ambitious project mutually beneficial complementarily the training activities planned will not only improve my research skills but also my independence mentoring and communication abilities preparing me for a young leader position able to transfer knowledge to both specialized and notspecialized audience
electrobiocatalytic cascade for bulk reduction of co2 to co coupled to fermentative production of high value diamine monomers

the access to platform chemicals made of co2 and nitrogen sources as starting materials via sustainable processes requires radical innovations driven by the global need of existing and growing markets combined technologies that make use of renewable energy and the greenhouse gas co2 and the use of natures catalysts such as enzymes and microbial cells through biotransformation steps are expected to have a game changing impact such catalysts can operate at ambient conditions at high atom efficiency through environmentally and energetically friendly processes in this context ecomo unites bioelectrocatalysis biohybrid materials sciences organic synthesis technical microbiology and process engineering for co gas fermentation to acetate and a subsequent production of diamines the fermentation steps will be achieved by specifically engineered microbial strains using co as both the carbon source and energy carrier as core novelty the co will be produced in situ apart from the electrode in the bulk solution from co2 through a mediated electron transfer to free floating beads where codehydrogenase is immobilized within the acetate forming bacterial cell culture this will enable for the first time full compatibility between electrochemical and biocatalytic processes the synthetic aim is to yield high valueadded diamine monomers as building blocks for established classes of polymeric materials ecomo will establish new bio based and biohybrid modules that will be directly compatible with the existing bioreactor infrastructure for the producing of specialty chemicals directly from co2 by achieving the production of diamines as a proofofconcept ecomo will foster further diversification to many other products made from co2 and thus enhances the synthetic availability of needed building blocks for the chemical industry the decoupling from fossilsourced energy and raw materials underpin the timeliness of ecomo
programmable aienabled deterministic networking for 6g

6g is envisioned to accelerate the path started in 5g for catering to the needs of a wide variety of vertical use cases both current and emerging this will require major enhancements of the current 5g capabilities especially in terms of bandwidth latency reliability security and energy predict6gs mission is therefore set towards the development of an endtoend 6g e2e solution including architecture and protocols that can guarantee seamless provisioning of services for vertical use cases requiring extremely tight timing and reliability constraints to succeed the solution will target determinism network infrastructures at large including wired and wireless segments and their interconnections predict6g will develop a novel multitechnology multidomain dataplane mdp overhauling the reliability and time sensitiveness design features existing in current wired and wireless standards the ambition is for the mdp design to be inherently deterministic to achieve this predict6g will develop an aidriven multistakeholder interdomain controlplane aicp for the provisioning of deterministic network paths to support time sensitive services as requested by endcustomers and with different scaling ambitions eg from the network in a single vehicle to a large geographically dispersed network this requires timely monitoring and prediction of the behavior of the complete network including identifying potential sources of quality violations and analyzing various routes of the traffic flows these capabilities will be delivered through the predict6g aipowered digital twin dt framework allowing the prediction of the behavior of the endtoend network infrastructure and enabling anticipative control and validation of the network provisions to meet the realworld timesensitive and reliability requirements of the running services
aibasedtechnologies for trustworthy solutions against disinformation

increasing evidence shows that disinformation spreading has nonnegligible impact on our society at individual and collective levels from public health to climate change it is of paramount importance to timely identify emerging disinformation signals such as content from known unreliable sources and new narratives especially from online social media to provide media professionals and policy makers with trustworthy elements to extinguish disinformation outbreaks before they run out of control however monitoring and analyzing large volumes of online content is well beyond the capacity of human ability only in fact regardless of the sociopsychological and behavioral reasons behind information forging the rate at which disinformation is produced is much larger than the rate at which it can be analyzed and its effects adequately mitigatedai4trust will provide a hybrid system where machines cooperate with humans relying on advanced ai solutions against advanced disinformation techniques to support media professionals and policy makers our system will monitor in nearly real time multiple online social platforms filtering out social noise and analyzing multimodal text audio visual content in multiple languages up to 70 of coverage in eu with novel ai algorithms while cooperating in an automated way with an international network of human factcheckers who will be periodically triggered and who will frequently provide validated data to update our algorithms the resulting quantitative indicators including infodemic risk will be inspected under the lens of social and computational social sciences to build the trustworthy elements required by media professionals to create customizable and reliable data reportswe expect that the ai4trusts system based on a humancentred approach to technology development that is aligned with european social and ethical values will be integrated in the standard toolbox of data analysts working on disinformation
is the presence of technology improving corporations and increasing the prosperity of investors and individuals

the use and importance of advanced technologies is continuously increasing in the corporate world technology is changing how investors interact with companies how investors analyze and interpret the information provided by companies and even the standard design of compensation in corporations the goal of this study is to understand whether and how the increasing presence of technology is improving corporations and contributing to the wealth and prosperity of individuals investors and when it is not i will focus on the following three pillars that each focus on a unique technological development 1 communication with shareholders aim to understand whether shareholders voice at shareholder meetings is muted following the shift of shareholder meetings from the inperson to the virtualonly arena due to covid19 initial findings indicate that this shift has minimized communication between shareholders and firms and allowed firms to strategically avoid addressing questions submitted by shareholders 2 environment and social es issues aim to understand whether investors pay attention to what firms say they do on es issues or what they actually do natural language processing nlp will be used to evaluate which actions firms state that they take with respect to es and these will be compared to the es actions firms actually take initial results indicate that the market rewards firms that state they take actions promoting es goals but not firms that actually take such actions 3 compensation aim to examine how the characteristics of employees eg gender working in the tech industry relate to the ebc they receive and their ability to maximize the value of their ebc and changes the economic landscape and welfare of individuals