Dragon09/odtu_chatbot huggingface dataset:
politics and practices of listening in mao era peoples republic of china

this research drawing on state archives private memoirs and literary materials provides the first dedicated history ofauditory cultures of the peoples republic of china prc by focusing on the act of listening across three pivotal andtransitional moments of prc history and at three levels of state locality and individual it explores the role of sound fromthree perspectives as a tool of nationbuilding deployed by the state as a medium through which the chinese revolutionwas experienced at an individual level and in the contestation between these two domains as the soundscape became asite of contention and negotiation between the state and the citizen the researchers background in social cultural andpolitical history of the mao era along with the supervisors expertise on chinese modern history and experience researchingthe history of sound and broadcasting in the republican era 19111949 will be deployed to provide the ideal backgroundfor this innovative but delimited project the key questions asked will be threefold 1 how and under what understanding ofthe act of listening did the state deploy sound as a political and social tool in the peoples republic of china 2 how weresuch state initiatives deployed at the local level and with what results 3 how was the act of listening among individualstransformed in response to state initiatives the resulting interdisciplinary research will expand the field of global soundstudiesbeyond its current eurocentrism apply soundstudies to china for the first indepth and long term empirical studyand enhance european knowledge of modern china
tracking impacts of climate change in the arctic marine ecosystems through cephalopod diversity and life histories

climate change is impacting global ecosystems especially in the polar areas of the earth countering climate change effects is stated as one of the key goals of both global development in the 2030 agenda for sustainable development and of regional development eg eu strategy of managing the arctic cephalopoda phylum mollusca are pivotal components in marine food webs and have life history and physiological characteristics that make them potential winners of climate change this group due to their ecology and biology features such as high abundance coupled with low taxonomic diversity high degree of opportunism ecological adaptability single reproductive cycle and typically a short lifespan cab ve used to assess and predict climate changeinduced shifts of arctic ecosystems thus the main objective of the action is to assess biodiversity life histories and ecological role of cephalopods in the arctic and their ontogenetic and temporary changes using both wellestablished and innovative methodologies in the climate change context the project addresses this matter via 3 scientific work packages that focus on the following research hypotheses hypothesis 1 diversity and distribution of current arctic cephalopod populations shifts due to climate changes hypothesis 2 environmental conditions experienced during the life of individual cephalopods can be documented and used to assess the climate change impact on life histories where comparing historical with new specimens will highlight climate change impact and hypothesis 3 the role of cephalopods in the arctic food web is even more pivotal then we currently understand and this would be tested with innovative food web modelling methods the results achieved will increase the quality of ecological monitoring in the arctic leading to more rational management of the arctic marine ecosystems in order to possibly counter climate change impact
substitution of rareearths for advanced novel magnets in energy and transport applications

modern technologies required for the transition to a climateresilient sustainable green and digital future wind generators electric motors heavily rely on rareearth ree permanent magnets however with china covering 98 of the supply to europe in 2022 the continent is left in an extremely vulnerable position with respect to these critical raw materials in this framework beethoven seeks to address the challenge brought forward in the topic description to reduce the amount of ree employed in the new energy sectorthe main goal of the project is to develop innovative and sustainable advanced magnetic materials that substitute ree in the energy and transportation sectors we will work on developing and upscaling 3 types of magnetic phases highentropy alloys ferritebased composites and wtype ferrites that could be deployed at large scale in the permanent magnets market substitution will be demonstrated in final applications by developing reebonded magnets for automotive components and by designing and building prototypes for a reelean wind generator a reefree flywheel and a reefreelean emotor for electric vehicles with a total budget of 75 million balanced between the parallel technological developments and across the projects value chain beethoven will address the 6 activities specified in the topic description to do so a team of experts from 14 partners and 10 countries with demonstrated experience working collaboratively at the frontier of knowledge in the permanent magnet sector has been assembled the successful implementation of the project is expected to put beethoven in the position to contribute to the expected outcomes and wider impacts of the call by reducing europes ree magnets imports by an estimated 22004900 tons by 2033 the key technologies skills and materials to achieve this impact will be developed within eu borders contributing to a more resilient autonomous and industrially competitive europe
empowering climatesmart circular and zerowaste use of underutilized wood from the forest and building stock in the construction sector to support the new european bauhaus

woodstock is a multifaceted project dedicated to advancing climatesmart wood construction practices in alignment with the new european bauhaus neb initiative a primary focus is the quantification and mapping of wood resources including underutilized streams using a novel tier 3 level harvested wood products methodology and dynamic material flow analysis modelling to gain insights into wood utilization potential climate mitigation impacts and resource availability this also entails a robust dynamic life cycle assessment lca methodology for the assessment of environmental social and economic impacts associated with various resource streams and scenarios woodstock will tap into collective expertise to develop zerowaste and circular building designs harnessing the power of digital twins assessing human health and wellbeing aspects by cocreation activities with a multitude of actors following the neb principles and values in 6 living labs lls in 6 different european regions through systemic circular solutions for zerowaste and communitybased wood construction aligning novel business strategies with policy recommendations and dedicated demo training and educational activities the project endeavours to incentivize climatesmart and increased sustainable wood use in construction an inspirational climatesmart guideline document for circular use of wood streams a woodbook with building blueprints based on the neb values beautiful together and sustainable and an euroadmap for the future are some of the key exploitable results kers that will be available on the european wood construction observatory ewco this observatory will be a central aipowered hub for best practices guidelines and innovative solutions facilitating knowledge exchange and collaboration among stakeholders and ensuring the longevity and impact beyond the projects lifetime in alignment with the neb academy
arrhythmogenesis in dilated cardiomyopathy role of mechanoelectric coupling

heart failure is a major cause of death in the western world with an estimated prevalence of 23 of the population a subgroup of heart failure patients is characterised by dilated cardiomyopathy dcm which results in substantial morbidity and mortality due to progressive mechanical pump failure 70 or sudden cardiac death from illpredictable electrical disturbances 30 dcm is commonly linked to mutations encoding cytoskeletal proteins but our understanding of why a loss of cardiac myocyte cytoskeletal integrity in inherited dcm phenotypes results in detrimental changes to calcium handling and how this causes arrhythmias and sudden cardiac death remains limited human studies have associated genetic mutations and loss in the cytoskeletal protein filamin c flnc with arrhythmogenic dcm and sudden death to explore the biomechanical and mechanoelectric mechanisms by which flnc deficiency leads to mechanical and electrical dysfunction i will use experimental and mathematical models that span multiple spatial and temporal scales from the protein level up to the whole heart i hypothesise that flnc regulates myofilament lattice spacing and that loss of this structure leads to impaired contractile force development by the sarcomere i postulate that these perturbations in mechanics may contribute to the generation of substrate for the induction and maintenance of lethal ventricular arrhythmias via a variety of mechanoelectric coupling mechanisms particularly stretchinduced alterations may affect cardiomyocyte electrophysiology which may contribute to both the trigger and the substrate for arrhythmias thus altered myocardial mechanics in the flncnull mouse model of dcm may contribute to the triggering or maintenance of lifethreatening reentrant ventricular arrhythmias via a variety of mechanoelectric coupling mechanisms
single item identification for forest production protection and management

the core objective of sintetic is to set up and demonstrate a traceability system for trees logs and boards based on ict through a central geodatabase covering all the forestbased value chainthis faces the 3 main drawbacks of the icts in the forestry sectordeployed only in areas with mature timber market northcentral eu vs south eucurrently cannot be used during the whole value chain causing several lossesa reliable tool for tracing the origin of forest product is missing still allowing illegal practicesalong with the core objective the sintetic proposal will pursuitsobj1 to achieve a higher value recovery of timber assortments 10 sobj2 to increase the overall efficiency of the timber supply chainsobj3 to provide a greater competitive advantage of the eu forest industry yield of high value sawnwood products from 20 to 22 sobj4 to increase of the eu forested area under active management aggregation of 12000 ha fragmented properties sobj5 to increase both the timber value the resilience and the ecosystem services provided sobj6 to tackle illegal logging and the related timber trade 15 sobj7 to facilitate a homogeneous and widespread uptake of the icts in the forest sector the main expected results areres1 manual marking and quality assessment traceability system res2 smartphone app for motormanual operations res3 processor head prototype res4 harvester lidar res5 sawmill sensors and traceability of sawnwood res6 earth observation illegal logging alert service res7 forest ownership aggregation platform to make all this possible sintetic will develop a geodatabase with a set of data providers interconnected by the traceability system itll provide1 multiplatform data acquisition for the whole supply chain2 data transmission with sesecured digital tools and physical ids on timber products3 data storage analysis and distribution for the generation of further services
comparative signature of marburg virus cell activation as a blueprint for the identification of antiviral targets against newly emerging viruses

identifying cellular attachment factors and functional receptors plays a critical part in developing an understanding of a newly emerging virus however the identification and therapeutic targeting of plasma membrane proteins critical for virus infection is often difficult due to the transient nature of viruscell binding and the overall kinetics of the infection process our goal is to interrogate virushost cell interaction and cellular uptake of marburg virus marv a highly pathogenic and clinically relevant member of the filovirus family to specifically target virusplasma membrane interaction we will use a unifying inverted infection platform that allows us to halt and synchronize virus infection at the cell binding stage our approach is compatible with bsl4 environment and multiomics technologies it will allow us to identify the signature of virushost cell activation ie proteins involved in viruscell entry in a tissuespecific manner this screen will be complemented by an innovative combination of proteomics virushost cell interaction analysis and imaging approaches to pinpoint and characterize the involved cellular and viral proteins their posttranslational modifications and how they mechanistically concert in viral uptake our unique combination of different technologies will lead to the identification of viral and cellular interaction partners which will in parallel be specifically targeted by highthroughput compound screening to identify small molecules that inhibit virusreceptor interaction moreover we will use our gained knowledge of tissuespecific posttranslational modifications to develop improved vaccine candidates as additional prophylactic countermeasures against marv our project will further deliver a blueprint experimental pipeline for the streamlined identification and antiviral targeting of proteins involved in the virus attachment process a critical cornerstone of pandemic preparedness
development of a novel highly efficient energy supply system for energy autonomous multifamily buildings based on biomass gasification coupled with an sofc and a pv system

the project aims at the development of an innovative resbased system for heat and electricity supply in order to achieve an almost energy autonomous multifamily building with regard to heating and electricity consumption as well as electromobility this shall be achieved by integrating a novel highly efficient biomass microchp technology based on an updraft gasifier a new gas cleaning system and a solid oxide fuel cell sofc a stateoftheart pv system and appropriate innovative energy storage solutions this system shall be economically highly attractive for future users and it shall also distinguish itself by virtually zero emissions of co ogc and dust as well as 55 to 65 reduced nox emissions compared to other biomass chp technologies consequently it shall increase the penetration of res on the multifamily house level and has the potential to significantly contribute to reaching the eu climate and clean air goalsthe key innovations of the project are related to the novel microscale biomass chp system they comprise a flexible partitioning of product gas supplied to the sofc and to a gas burner in order to cover the overall heat demand and to maximise sofc operation at the same time a novel combined thermal and catalytic tar reformer new highly efficient and durable stack units and a novel compact sofc system with integrated hcl and h2s removal reactor based on a 25 kwel sofc with an electric efficiency of 44 which is flexibly coupled with a 14 kw gasifier overall efficiencies of more than 90 shall be gained a trl of 5 shall be achieved at the end of the projectthe methodology applied to reach these goals relies on technology development tasks based on process simulations cfd aided design of the single units test plant construction performance and evaluation of test runs a technology assessment part covering risk technoeconomic environmental and overall impact assessments as well as targeted dissemination activities
leveraging crisprcas for fast and accurate pointofcare diagnostics

in the healthcare sector rapid and precise pointofcare diagnostics is indispensable for enhancing patient outcomes particularly in critical scenarios such as sepsis and organ transplantations present in vitro diagnostic technologies often strike a compromise between accuracy speed portability and costeffectiveness immunoassays offer rapidity but sacrifice accuracy while molecular diagnostics like pcr deliver accuracy at the expense of time and ease of use isothermal molecular tests on the other hand are swift but lack specificity hence a pressing need persists for pointofcare diagnostic tools that embody userfriendliness costefficiency high accuracy and adaptability to diverse applications at scope biosciences a spinoff from wageningen university we have developed and patented a crisprcas diagnostic technology scopedx that harnesses the precision of pcr and the speed of isothermal amplification delivering rapid results within approximately 30 minutes at the point of care futhermore the scopedx platform can be rapidly adapted to new applicationsour objective is to complete the preclinical validation of our solution to offer userfriendliness robustness portability and costeffectiveness providing swift results directly at the pointofcare besides we aim to prove the versatility of our platform which can be extended to the detection of various pathogenic microbes viruses bacteria fungi and genomic applications stemcell tissue transplantationsin essence scopedx constitutes a modular platform technology with the potential to revolutionize the pointofcare diagnostics market comprehensively
personalized medicine in chronic kidney disease

in 2017 on a world scale the total number of individuals with chronic kidney disease acute kidney injury and those on renal replacement therapy exceeded 850 million a truly concerning figure that is twice the estimated number of people with diabetes worldwide and 20 times higher than the number of individuals affected by aidshiv worldwide the socioeconomic impact of kidney disease is huge and is anticipated to even further grow in the coming years awareness of the magnitude and the risks of this condition have remained low at the population level therefore kidney disease has been until recently largely overlooked by health authorities and governments in most countries with as the result accumulation of major unmet needs in personalized medicine in kidney disease the aim of picked personalized medicine in chronic kidney disease is to equip a generation of 10 doctoral candidates dc with interdisciplinary skills for the development of pathways to implement personalized medicine in chronic kidney disease and their complications on the level of its detection progression and treatment we anticipate that these dcs will significantly contribute to the increasing possibilities to stratify patients with kidney disease and the development of successful intervention procedures with potential to substantially impact the lives of over 10 of the european population picked will realize this aim by coordinating the efforts of 10 beneficiaries and 8 associated partners across 7 european countries and 3 sectors with lead supervisors covering a large range of disciplines ranging from biomarkerresearch to research into the legal ethical and quality of life aspects for the implementation of personalized medicine in kidney disease
modelbased estimation of railroad wheeltorail profile change and contact forces

the eu wants to encourage train travel due to the current climate crisis and innovations to the railway system are necessary because trains run around the clock in 23minute intervals it is difficult to monitor the status or the conditions of a railway equipment efficiently without interrupting railway operation and it only reduces the likelihood of its failure detect4we will offer a novel solution to help keep infrastructure safe in this project the condition of the tracks and the inservice trains are continuously monitored by smart sensors and the collected measurement data and safety analysis of trains are processed in real time therefore a highly detailed forecast is ensured this approach promises cost savings for vehicle manufacturers because of relatively inexpensive instrumentation techniques and shared computer analysis systems and because more timely and accurate accident prevention will be available train travel will become safer leading to zero fatalitiesthe detect4we project will be carried out by the experienced researcher who worked during her phd thesis on the pure computational analysis of railway vehicle multibody dynamics and wanted to practice her research into applied railway engineering using experimental methods and make connections within railway industry she will collaborate with prof jos l escalona at university of seville prof zili li at delft university of technology both supervisors have strong background in computational and experimental dynamics of railway vehicles and tracks in the end a final sixmonths nonacademic placement will be carried out at the company prorail ltd under the supervision of prof rolf dollevoet the academic and nonacademic stay will give her the unique opportunity of modelling experimentally testing and validating innovative methods in the field of railway engineering importantly extending her professional training towards becoming a selfsupporting scientist
functional characterization of the colorectal cancer metastasis microbiome

host cells and microbial inhabitants form an intricate ecosystem in the human body extensively influencing host phenotypes in health and disease despite much progress in sequencingbased cancer microbiome research elucidating functional roles of bacteria in metastasis formation remains an important unsolved challenge in the metabac project we will explore such bacterial roles as drivers of colorectal cancer metastasis we will investigate new concepts on whether bacteria can equip cancer cells with malignant features migrate within the host and potentially represent targets for cancer therapyin aim 1 my group will characterize the microbial inhabitants of colon tumors and metastases we will uncover bacterial species and their genetic features in metastases by using sequencing imaging and culturingbased approaches in aim 2 we will mechanistically dissect functional impacts of metastasisderived bacteria on distinct stages of the metastatic process for this we will use specialized organoid organ chip and orthotopic organoidbacteria coengraftment platforms that we have pioneeredin aim 3 uncovering the tropism timing and routes of bacterial migration to different metastasis sites takes center stage bacterial strains and organoids derived from different metastasis sites will be coengrafted into mice and traced to lymph node liver and lung metastasesthe metabac project will provide an unprecedented characterization of microbial roles in metastasis our combination of metastasisderived bacterial strains with novel organoid organ chip and in vivo platforms puts us in a unique position to close the gap between cancer microbiome sequencing and mechanistic studies and promises groundbreaking functional insights into hostmicrobe interactions in cancer and beyond