Dragon09/odtu_chatbot huggingface dataset:
structural determination and dynamics of the mitochondrial import protein mim by cryoem and magicanglespinning mas nuclear magnetic resonance nmr

mitochondria perform numerous key functions from energy production to metabolic pathways and are involved in ageing and cell death all these functions rely on about 1000 different proteins of which 99 are synthesized outside the organelle and have to be imported and inserted into the right compartment these import and insertion are particularly demanding for the membrane proteins as they are inherently aggregationprone how helical membrane proteins mps are inserted into the mitochondrial outer membrane mom is currently poorly understood in particular the structure of the insertase responsible for inserting tens of these helical mps into this membrane called mitochondrial import protein mim in yeast is unknown my mitomeminsert project addresses this important knowledge gap by determining the atomicresolution structure of mim by using cryoem combined with magicanglespinning nuclear magnetic resonance spectroscopy to resolve mims structure in a lipidbilayer environment this will open avenues to see how the mim complex engages with polypeptides that shall be inserted into the membrane by mim socalled precursor proteins or preproteins such a static structure determination would already be a big leap for the field it will be the first structure of a mom insertase of helical mps as it is thought to have a novel architecture this structure will provide new insights into mp insertion machinery in general in addition i will use nmr to study the dynamics of this machinery which i believe will add important mechanistic knowledge of how the mim complex engages with mps that are being inserted in the mom overall making use of my previous technical expertise and adding new competences to my skill set a combination of biophysical and structural approaches will allow me to resolve this important and hitherto poorly addressed question in mitochondrial biogenesis and more generally biophysics
obtain flight mission readiness enabling rapid intervention for healthcare and critical infrastructure leveraging all value chain actors and uspace services

safirready aims to develop new uspace services relevant for u3 and u4 that together with a central command and control center c2c and the development of an automated ground integration drone cargo port dcp will allow for automated time critical drone based services for medical and nonmedical use cases to achieve this the consortium will focus on the development of a dynamic capacity management system u3 detect and avoid algorithms u3 and machine to machine communication and decision making u4 the medical use cases have already been demonstrated in the predecessor project of safirready safirmed these use cases consist of urgent transport between of from hospital rooftops for clinical samples blood products medicines and aeds the safirready project will extend these use cases with nonmedical critical missions inspection flights for railways and electrical grids these flights can be planned eg routine inspections of infrastructure but can also be time critical in case of unforeseen issues with the infrastructure eg tree fallen on high tension cable shore to ship for transport of materials inspector or pilotage passenger the consortium will demonstrate the new uspace services in executing the aforementioned use cases in three different regions antwerp be tartu ee and flushing nl in parallel research will be done around social acceptance privacy protection and environmental impact the figure below shows how one base set up consisting of the helicus command and control center a drone agnostic drone cargo port and various uavtypes cover a various set of uses cases
bottomup assembly of synthetic neural networks from biological matter

the longterm objective of my lab is the construction of synthetic neural networks from biological matter in this way we not only will understand how to build sustainable computing architectures but also provide a novel bottomup approach towards understanding biological neural networks to make progress in this direction i ask what is the minimal assembly of biological components that allows for biorealistic electrical information processing clearly voltagesensitive ion channels form the molecular basis for electrical spiking activity in neuronal networks however spatial propagation of spikes is not a property inherent to individual ion channels but rather emerges from the arrangement of ion channels along a tubular lipid membrane the axon while the reconstitution of functional ion channels outside of living cells has been well established the propagation of an action potential along a lipid bilayer nanotube has not yet been shown similarly the physical realization of larger nonliving spiking networks using biological matter remains elusive here i propose to move forward from the stateoftheart by a studying action potentials propagating along lipid nanotubes and demonstrating their electrical cable and spiking characteristics b understanding the coupling between membrane elasticity and electrical characteristics and how electromechanical coupling remodels and reshapes membranes and nanotube networks c exploiting these remodeling reshaping and selfhealing abilities for biomimetic molecular mechanisms of information processing this research is a challenge of enormous complexity in this proposal i argue that this challenge can be overcome using recent methodological advances my preliminary data and my research experience combing electrical engineering biophysics and synthetic biology will enable this leap in our understanding and design of biological neural networks
optimization of free space optical communication link based drones for search and rescue operations in the arctic region

the arctic region is witnessing more frequent shipping accidents than ever which require accurate search and rescue operations the existing communication systems use drones with radio frequency rf technology which has limited bandwidth and cannot offer 4g5g connectivity due to harsh weather constraints it further limits the capacity of drones and affects the resolution of images and videos the current research proposes to design free space optical communication fsoc linkbased drones that can enhance connectivity between multiple drones and rescue ships as well as the capacity of drones to produce high resolution images and videos the proposed fsocbased drones can provide highspeed connectivity than the existing rf technology the research will collect atmospheric turbulences data from the arctic region and use it for designing the fsoc link furthermore to enhance the capacity of fsocbased drones the research will design advanced multiplexing schemes mode division multiplexing and orthogonal code division multiple access and to ensure link stability omnidirectional receiver will be designed the research will further evaluate the performance of proposed fsoc link under the impact of various atmospheric turbulences the expected outcomes of this research will lead to the optimisation of fsocbased drones in expanding search areas and improving communication systems for sar operations in the arctic region
immunogenic cell death icd in the cancerimmune dialogue

the success of most if not all anticancer treatments depends on the reactivation of immunosurveillance as this has been documented for several therapeutic modalities not only immunotherapy but also chemotherapy targeted therapy and radiotherapy in response to antineoplastic drugs malignant cells can undergo immunogenic cell death icd thus exposing and releasing danger signals that act on pattern recognition receptors expressed by immune cells in particular dendritic cells dcs to trigger the first steps of a therapeutically relevant anticancer immune response based on solid preliminary data and novel methodological approaches we propose to obtain fundamental insights into the physicochemical properties and molecular mode of action of pharmacological icd inducers objective 1 to create chemicalgenetic systems for synthetic icd induction for the study of icd effects on the immune system without perturbation by pleiotropic anticancer drugs objective 2 and to identify new icdrelevant immune checkpoints acting at the level of dcs objective 3 we will use this knowledge to generate an integrated view of the cancerimmune dialogue ignited on one side by malignant cells succumbing to icd and on the other side dcs perceiving icd hence developing optimal strategies for the stimulation of tumor immunosurveillance objective 4 the concept of icd has already been useful for patientrelevant biomarker discovery drug development and trial design strongly suggesting that a deeper exploration of this phenomenon will yield clinically relevant information
towards cryogenic applications of alta codoped nicocr medium entropy alloy enabled by selective laser melting

highmedium entropy alloy heamea with multicomponent elements is a novel alloy system developed beyond the traditional metallurgical design the newly developed foreignelementdoped nicocr mea has demonstrated greater potentials to achieve excellent mechanical performance at low temperatures due to the strengthening effect resulting from the foreign elements as an important component of industry 40 selective laser melting slm as a branch of additive manufacturing has become a major industry in eu and worldwide however to date few to no efforts have been devoted into the investigation of nicocr mea fabricated by slm thus the fundamental knowledge associated with the microstructures and properties of slmed nicocr is still lacking it is clear that such lack of critical knowledge is a hard barrier for the further development of nicocr parts used in cryogenic environment seeing this potential this project proposes a novel alloy design strategy by incorporating nanosized alti codoped nicocr powder into the slm process this proposal will focus on 1 alloy composition design used for slm 2 investigation of layerbylayer twinning mechanism 3 temperatureinduced mechanical response upon tension deformation 4 tailoring of cryogenic strengthductility synergy the combination of alti codoping and slm process create a possibility for slmed nicocr to enable different microstructures and superior properties over its conventionally manufactured counterparts it is expected that the new knowledge generated from this project will allow the 3d printing of complex mea parts with excellent strengthductility balance in cryogenic environment this proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques results have the potential capacity to increase the competitiveness and provide room for further studies at the fundamental and applied levels in additive manufacturing
mediterranean mass mobilities and displacements in the age of steam 18691914

during the second half of the nineteenth century the technological revolution profoundly reshaped maritime transport accelerating the circulation of passengers and allowing steamships to be used for the first time to move large masses of people across the sea cheaply alongside migrants crossing the sea to relocate within the mediterranean basin or to reach hub ports for transoceanic migration steamships teemed with masses of refugees pilgrims deportees workers engaged in cyclical or occasional movements to access integrated labour markets and even enslaved people often smuggled as ordinary passengers in their movements they all experienced varying degrees of freedom and coercion determined by the vital interest of colonial empires and nascent nationstates in controlling and managing mass flows across the mediterranean for political economic and public health reasons once at sea however these heterogeneous masses were all forcibly united by a single carrier the steamship and the same status of passengers medmad proposes a novel approach to the study of mass mobility in the wider mediterranean including the black sea and the red sea between the opening of the suez canal in 1869 and the beginning of the first world war in 1914 the projects overall objective is to examine from a global perspective the development of mass transport maritime services in the mediterranean during the age of steam and analyse their impact on inter and extramediterranean mobilities and displacements of passengers travelling in lowcost classes third and fourthclass or deck passengers as defined by the ticket
cocreating more connected ecosystems to transition european innovation

the wennovate project is a collaborative effort to create new systems and solutions to address urgent complex and systemic challenges the focus is on the transition to sustainable renewable energy and crosssector activities in energy and digital innovations aligned with the european commissions energy directives the project aims to strengthen the pathways towards clean energy for all europeans and boost local energy communities and energy sharing social entrepreneurs and professionals play a critical role in developing new solutions to societal problems and environmental challenges making them important drivers of innovation the project is divided into two phases an exploratory phase focusing on social entrepreneurs with deep tech and digital innovations and a stakeholder engagement phase focusing on engaging stakeholders to gather insights for faster alignment on policy advice and action planning the projects partners come from hungary slovakia ukraine and the netherlands with a complementary role in ensuring the widest possible engagement of dialogue with ecosystem actors and the sound delivery of transitional action plans the wennovate project aims to contribute to the achievement of the sustainable development goals and the strategic objectives of the new european innovation agendathe project will conduct research and codesign methodology to building partnerships analysing existing innovation agendas and strategies identifying areas of competitive advantage for sustainable economic growth and mapping gaps needs and opportunities the consortium will also enhance synergies and complementarities of their programmes and encourage the alignment of their innovation and related policies impacting innovation in line with the new european innovation agenda as well as creating new frameworks to support ecosystems
manufacturingasaservice framework exploiting decentralized secure data exchange promoting sustainability and circularity

the projects main objective is to develop a highly innovative securebydesign framework that fully exploits the maas paradigm this framework will offer secure data exchange between companies and cuttingedge tools to enhance production efficiency and sustainability the medusa framework will establish a seamless connection between existing marketplaces facilitating optimized production by leveraging users machinery and shared resources from other manufacturers all resources will be treated as part of a distributed cyberphysical system of systems cpsos maximizing production the implementation of an automation layer will enable the exchange of realtime production data and asset monitoring allowing for the tracing and optimization of the product life cycle the framework will also support the implementation of a dpp and provide aibased tools for manufacturers to support decisionmaking for production planning remanufacturing and machine reconfiguration always being energyaware
microplastic contamination in agricultural soil ecosystems and the effect on soil and plant health

plastics are found in nearly every environment and disrupt key ecosystem services while the effect of plastic in marine and freshwater ecosystems has been studied extensively effects of plastic on soil ecosystem functions such as plant growth microbial biomass and water permeability have been mostly overlooked particularly for the smallest particles the microplastics mps 5 mm the lack of appropriate techniques and methodologies for sampling extraction and detection hamper the research concerning mp distribution in soil ecosystems this research gap has led to fragmentary knowledge and even contradictory results in mp studies on soil ecosystems as different concentrations sizes shapes and mp polymer types were considered therefore fundamental insights in the role of mps on soil and plant health are missing we will advance the field by working in a three step approach to mechanistically define how mp pollution outbalances the soil and plant ecosystem first the risk of mp pollution in soil will be assessed by correlating mp concentrations of 240 soils with soil health indicators to measure the mp concentration a fast costeffective and standardized method to detect identify and quantify mps 1 m in soils will be developed second these correlations between mps and the soil health indicators will be validated and tested in greenhouse experiments to understand the biological underpinnings that drive these correlations mp induced changes in plant growth plant disease susceptibility soil texture soil chemical composition and the microbial community will be studied third to reduce the risk introduction and accumulation of mps in soil ecosystems we will actively search for biodegrading organisms making use of a novel sequencing approach with this multidisciplinary approach we will be able to mechanistically define the effects of mps on soil and plant health and advance the field by identifying plasticbiodegrading microorganisms
the role of pentagons in the conversion of polycyclic aromatic hydrocarbons into fullerenes in the interstellar space

the unidentified infrared uir bands are discrete emission features observed in the interstellar medium ism circumstellar regions galactic and extragalactic sources the uir bands are very characteristic for the cc and ch vibrational modes of polycyclic aromatic hydrocarbons pahs pahs are thought to occur in the ism either in the neutral cationic protonated hydrogenated dehydrogenated or substituted forms in spite of many theoretical and experimental investigations for several decades the exact form of pahs or the group of pahs responsible for the emission of the uir bands still remains a major challenge in astronomy observations reveal that large pahs with 30 to 100 carbon atoms harbors 1015 of elemental carbon in the ism these pahs are suggested to play an important role in the ionization and energy balance of interstellar gas fullerene c60 has also been identified in the ism through its infrared bands and its electronic transitions observations have revealed that the abundance of c60 increases rapidly while the abundance of pahs decreases close to stars this has been attributed to photochemical fragmentation and isomerization processes under the influence of the strong uv radiation field but the details of this are not at all understood this project focuses on larger 20 c 30 c and compact pahs that have the high photostability to withstand the intense uv radiations in space and hence could be present at high abundances in the ism i propose to study the photofragmentation pattern of astrophysically relevant pahs using the instrument for photodynamics of pahs ipop housed at the university of leiden i would further extend this research to record the infrared spectra of the pah ions stored in a 22pole cryogenic iontrap at felion using intense and tunable free electron laser for infrared experiments felix facility the data obtained in this project will be timely for the upcoming james webb space telescope
demonstration and mainstreaming of naturebased solutions for climate resilient transformation in the mediterranean

climate change cc is an increasing threat at european and global scale affecting social stability public health and well being the mediterranean med has been recognized as a cc hotspot and is among the least economically developed of the main eea european biogeographical regions adapting to cc demands requires a radical shift from piecemeal to transformative strategies and approaches supporting policy development at all levels and advancing transversal and multilevel governance solutions naturebased solutions nbs to preserve and restore ecosystems increase climate resilience sustainably manage the environment while providing wider longterm socioeconomic benefits are at the heart of the european cc adaptation cca mission adaptation plan objective to support at least 150 european regions and communities to become climate resilient by 2030 and a main eugd pillar in desirmed nbs will be prioritized together with innovative technologies and inclusive social practices desirmed will increase ambition ownership and capability of regional med leaders and communities through proven transformative cca approaches recognising that successful adaptation generally occurs at local and regional levels desirmed involves a multilevel set of actors in 5 demonstrating regions drr and 3 replicating regions rrs working hand inhand with scientific partners to foster holistic approaches to implement transformative adaptation desirmed by engaging at the regional level key institutions in a multilevel governance framework will act as a catalyser to trigger and accelerate the necessary action in key community systems overall desirmed will strengthen knowledge and capabilities of med regions and communities to take leadership and ownership in their transformative cca pathways and accelerate the implementation of transformative solutions required to increase their resilience over the long term
transport research arena 2026 budapest

the tra2026 project aims to support the organisation of the tra conference in budapest in 2026 and deliver the related competitions this proposal aligns with the specified criteria of the call namelyit addresses the expected outcomes including enhanced visibility of the transport sector contributions to advancing knowledge improved cooperation opportunities as well as increased attractiveness of transportrelated studies as well as recognition of outstanding achievements in this fieldit features a partnership representing the host country and city authorities as well as the academic and professional realm with a strong international reach the proposal involves partners with experience across all transport modes and crossmodal themes as well as in organising past tra conferences and researcher competitions a member state responsible for the council of the european union in 2026 is also represented in the consortiumthe partners will work together and with relevant stakeholders drawing on the traditions of previous tra editions to bring together key actors in the transport sector to find joint solutions for current and upcoming transportrelated challenges