Dragon09/odtu_chatbot huggingface dataset:
the basic principles of polyploidy in plants and animals

many eukaryotes have more than two sets of chromosomes due to wholegenome duplication wgd and are called polyploids wgds explain many cases of speciation bursts and evolutionary inventions some evidence suggests an adaptive advantage of polyploids the origins of many ancient wgds correspond to the times of extreme climate change and contemporary polyploids often occupy harsher environments compared to their ancestors however most new polyploids are not as lucky and rarely survive to explain the cause predict and manipulate this process we need to understand the basic principles of polyploidy 1 how it is triggered 2 what enables the initial survival of newly formed polyploids and 3 how they stabilize a population and become successful my program will comprehensively cover all these aspects from the functional and genetic levels to the evolutionary forces driving the entire process i propose a crossdisciplinary approach to identify common polyploidy principles in plant and animal diploidtetraploid species complexes arabidopsis lyrata widespread plant in northern hemisphere and neobatrachus burrowing frogs living in the australian desert the approach combines classic genetics with the latest genomics technologies and population genetics analysis of natural herbarium and museum collections across broad geographies i will 1 expose genetic and environmental predispositions to polyploidy formation by mapping natural variation of the unreduced gametes rates 2 reveal mechanics and genetics stabilizing meiosis in polyploids comparing recombination and selection across ploidies 3 uncover polyploid populations recovery processes after bottlenecks accompanying their origin by reconstructing introgression patterns deciphering the mechanisms leading to successful polyploidization across the plant and animal kingdoms will deliver groundbreaking advances relevant across biology agriculture and medicine
cuttingedge food waste solution for restaurants

worldwide onethird of all food production is wasted 15 of which is generated by restaurants hotels and caterers who lack the tools to reap the benefits of reducing food waste our product binspector combines a smart camera a smart scale and artificial intelligence image recognition technology to automatically register all food going to waste and supply actionable insights to chefs on how to optimize inefficiencies integrated with external systems our product will even prefill restaurant ordering systems we offer our productasaservice to professional kitchens for a monthly fee with no upfront costs it will allow an average kitchen to decrease its ecological footprint and food waste level by 70 and easily save over 30000 annually resulting in a net profit margin increase of up to 2 the market is estimated to be worth 78b in europe alone founded in 2019 orbisk is a dutch startup with a team of 24 engineers data scientists and commercial specialists
adaptive scheduling and deployments of data intensive workloads on energy efficient edge to cloud continuum

enact develops cuttingedge techniques and technology solutions to realise a cognitive computing continuum ccc that can address the needs for optimal edge and cloud resource management and dynamic scaling elasticity and portability of hyperdistributed dataintensive applications at infrastructure level the project brings visibility to distributed edge and cloud resources by developing dynamic graph models capable of capturing and visualising the realtime and historic status information connectivity types dependencies energy consumption etc from diverse edge and cloud resources the graph models are used by ai graph neural networks gnn models and deep reinforcement learning drl agents to suggest the optimal deployment configurations for hyper distributed applications considering their specific needs the ai gnn and drl models are packaged as an intelligent decisionmaking engine that can replace the scheduling component of opensource solutions such as kubeedge this will enable realtime and predictive management of distributed infrastructure and applications to take full advantage of the potential compute storage energy efficiency etc opportunities in the ccc enact will develop an innovative application programming model apm the apm will support the development of distributed platform agnostic applications capable of selfdetermining their optimal deployment and optimal execution configurations while taking advantage of diverse resources in the ccc an sdk to develop apmbased distributed applications will be developed moreover services for automatic zerotouch provisioningbased resource configuration and telemetry data collections are developed to help design and update dynamic graph models enact ccc solutions will be validated in 3 usecases with challenging resource and application requirements international collaboration is planned as japan productivity center has committed to support with knowledge sharing
the impact of cosmic rays on the interstellar medium

in recent years there has been an increasing interest in the impact of cosmic rays crs on the evolution of galaxies the fact that the local cr energy density is comparable to the turbulent and magnetic energy densities implies that crs can potentially influence the dynamics of the interstellar medium ism regulating the level of star formation and driving largescale outflows moreover crs have long been known to be a key source of heating and ionization in the dense ism shielded from photoionizing radiation despite the considerable progress made in the field there are still uncertainties in modeling the galacticscale transport of crs as a result the extent to which crs impact ism structure and evolution is yet unclearecosystem will provide a significant step forward in the field thanks to stateoftheart mhd simulations modeling the transport of spectrally resolved crs and their interplay with the ambient gas with unprecedented physical detail these simulations will employ a new algorithm in which the propagation of crs depends on the properties of the multiphase ism and crs themselves to cover multiple ism scales and conditions the project will combine simulations of kpcsized portions of galactic disks representative of galactic environments typical of milky waylike galaxies with zoomin simulations of individual molecular clouds and will explore different galactic properties in terms of star formation rate gas surface density and gravitational potentialthis project will deliver a comprehensive theoretical investigation of how the distribution of crs in space and energy vary with the dynamical thermal and magnetic properties of the gas three questions will be addressed thanks to ecosystem 1 what is the impact of crs within the ism disk and for galactic wind driving 2 how do the largescale spatial and spectral distribution of crs depend on galactic environment 3 what sets the cr ionization rate in the dense ism
upgrading of lowquality iron ores and mill scale with low carbon technologies

growing demand for high quality iron ores and scrap as well as abandonment of carbon intensive sintering in the future require novel technological approaches for upgrading of lowgrade iron ores and recycling of mill scale transzerowaste will apply hydrometallurgy for mill scale deoiling and use this ironrich scrap equivalent to upgrade lowgrade iron ores for that transzerowaste will develop low carbon technologies such as cold pelletising and briquetting hot microwave pelletising and magnetsupported hydrometallurgy from trl 6 to trl 8 the developed technologies will be transferable to further material flows such as dusts and sludgeson european level the expected impact will be the potential upgrade of over 18 million ta lowgrade iron ore up to 6 million ta mill scale and 3 million ta pellet sieving residue total impact of transzerowaste will include upgrading of 27 million ta materials with low carbon technologies and avoiding of corresponding sinter plant carbon footprint of 43 99 mtco2atechnological competences and knowhow are owned by the participating partners from the applied research they will be developed and transferred to the two industrial partners with 9 production sites thoroughly planned dissemination and exploitation activities will ensure effective implementation of technologies after project end life cycle assessment and economic evaluation will be performed sustainable business models will be developed furthermore a decision support platform for industrial users will be installed in combination with workshops and trainings it will help to find and implement the best upgrading technology for various lowgrade materials considering environmental and economic aspects transzerowaste will serve as a vehicle for the transition of the european steel industry to the carbon free zero waste future
graphene alliance for sustainable multifunctional materials to tackle environmental challenges

giance offers innovative solutions to environmental challenges and establishes a holistic integrated and industrialdriven platform for the design development and scalable fabrication of the next generation of costeffective sustainable lightweight recyclable graphene and related materials grmbased multifunctional composites coatings foams and membranes grmbm with enhanced properties eg thermal mechanical chemical functionalities eg wear corrosion chemical and fire resistance hardness and impact resistance high temperature resistance structural health monitoring ultralow friction surfaces and as enablers for hydrogen storage giance will also advance manufacturing processes enhancing synthesis and stability and reducing environmental impact such grmbm and manufacturing capabilities will allow robust connections with endusers and thus develop and qualify the commercial propositions to high trls giance will develop demonstrate and validate the efficacy of grmenabled products 11 use cases which will underlie future technologies for different sectors eg automotive aerospace energy hydrogen economy and water treatment giance also supports the innovation output and industrialization efforts of the graphene flagship initiative building a credible pathway for the newly accumulated knowledge to impact eu industry and society giance will support a strong eu value chain in translating technology advances from trl45 into concrete innovation opportunities and production capabilities trl67 with firstmover market advantages of scale in the defined industrial sectors the consortium consists of 23 partners from 10 countries representing the full value chain with leading oems large industries worldclass research and education organisations and innovative smes giance is designed to ensure maximum impact for the defined industries and society as a whole significantly contributing to the evolving field of grm
local sound for a new musicality enhancing musical participation through a local sonic practice

participation in musicmaking has shown to produce cognitive and behavioural benefits enhance social participation and contribute to shaping both individual and collective identity however access to musicmaking is reserved for people who possess some level of specialised musical training lomus aims at developing a pioneering method that uses easytouse calabrian sounding objects as a tool for facilitating nontrained individuals participation in musicmaking it unlinks musicproduction abilities from specialised instrumental training to enable nonmusicians to make music without requiring mastery of an instrument of specific musical idioms and techniques by combining ethnomusicology contemporary music and community music studies lomus provides a sophisticated understanding of a local sonic practice and investigates how this could inform the emergence of a new global practice for musicmaking that challenges public conceptions of musicality and of a musician the research will study the calabrian sounding objects to understand how they contribute to shaping the musicality of the community and how they could contribute to creating new types of musicality investigate contemporary music practices and strategies that can be used to include nontrained individuals in musicmaking develop a new method that uses calabrian sounding objects and contemporary music strategies to enable amateurs and nontrained individuals to make music the resulting method will be relevant to different rural or urban communities and it can be used to explore elements of a communitys soundscape as an inclusive tool for musicmaking lomus challenges established concepts and practices around music and musicality promotes social innovation by initiating new ways of relating with others and the environment through sound and extends the personal and social benefits of musicmaking to everybody
multicomponent soft materials advanced research training network

multismart multicomponent soft materials advanced research training network is a doctoral network of six universities one private nonprofit research institute two large companies and an sme involving training fundamental research and applications in the field of molecular soft materials these have substantial societal and economic impact but require innovation to ensure sustainable development the primary research objectives are defined as i the innovation in soft materials through multicomponent selfassemblies ii the application of these materials in the formulation of actives with elevated performance in the largescale industries of personal care and home care as well as highadded value regenerative therapies multicomponent systems based on low molecular weight gelators have considerable potential to achieve these goals with the key advantages of programmability and responsiveness however their development hinges upon the formation of an interdisciplinary network with welltrained researchers multismart proposes 1 the training of the future generation of researchers 2 the tight integration between academic projects and private sector needs 3 a networkwide seamless multidisciplinary international and intersectoral training that is not available at any one institution multismart will be formed around 9 hired researchers who will have the opportunity to become scientists employable in both the industrial and academic sectors in an integrated approach they will be trained to bridge the gap between chemistry physics biology and formulation technology as well as to acquire transferable skills through their research and specifically designed networkwide schools and workshops the participation of three industrial participants in research and training programmes will guarantee extensive intersectoral experience for the trainees and maximise the impact of the network
immunometabolic regulation of the host response to viral infection in the context of obesity

chronic viral diseases are of significant concern to the public health due to lack of effective vaccines and paucity of potent antiviral medication notably individuals with obesity exhibit higher morbidity and mortality due to viral diseases however what specific mechanisms underlie the confounding effects of obesity on the overt outcome of viral infections remains poorly understood in preclinical studies i found that obese mice developed profound and progressive loss of fat and muscle in response to chronic viral infection while metabolically healthy animals showed only transient and significantly milder manifestation of tissue wasting in response to the virus in this proposal i aim to identify the mechanisms driving this marked and progressive tissue wasting in infected obese mice inflammation and disrupted glucose homeostasis have been implicated to play a role in tissue wasting i hypothesize that the profound tissue wasting during viral infection results from uncontrolled glucose homeostasis perturbations in macrophage functions and from abnormal cytokine profiles observed in the context of obesity i will test my hypothesis using highfat dietinduced mouse model of obesity infected with chronic strain of the lymphocytic choriomeningitis virus i will test the involvement of cytokines macrophages as well as of glucose homeostasis in the progressive wasting in infected obese animals and evaluate if there is a crosstalk between these three factors during infection in an obese host this project will generate critical knowledge to address why host response to virus is disrupted in the context of obesity and identify potential therapeutic strategies for improving the outcome of viral diseases such as tissue wasting in this metabolic disease moreover this study will highlight the crosstalk between the immune system and body metabolism during infection and will help to better understand the processes underlying immunity to pathogens
watching excitons in photoactive organic frameworks

one of the most urgent challenges our society is facing nowadays is the development of an energy economy based on renewable resources a fascinating approach is artificial photosynthesis where solar energy is exploited to produce chemical fuels out of carbon dioxide water and sunlight while recent technological advances are bringing us closer to the goal of developing efficient lightharvesting platforms a fundamental gap about the atomicscale mechanisms remains to be filled understanding the atomistic details of the processes involved is of tremendous importance to drive a rational design of photoactive materials relevant questions include how do electrical charges move upon light absorption how does the atomic structure influence the ability to harvest light why do some materials work better than others answering to questions as these represents an extraordinary demanding task since excitons the most fundamental lightinduced excitations composed of bound electronhole pairs are only transient shortlived entities occurring in complex materials the wepof project aims at enabling the direct experimental observation of excitons in photoactive covalent organic frameworks providing a fundamental understanding of photoexcited states in energy materials while the structural complexity of organic frameworks will be tackled by individuating elementary functional units allowing rationalizing their structurefunction relations the development of unique scanning probe microscopy methods will enable to watch excitons on their relevant length and timescales the understanding of excitonic processes will allow steering the design of photoactive materials with improved energy conversion efficiency providing a conceptual framework for nextgeneration material platforms for artificial photosynthesis
studying the microenvironment and related targets in nonhodgkins lymphoma

the tumor microenvironment tme plays an essential role in tumor evolution and response to therapy understanding the complex network comprising tumor and immune cells is critical for the success of cancer immunotherapy cll and mcl are two nonhodgkins lymphomas characterized by accumulating cd5 small and mature b lymphocytes in peripheral blood bone marrow lymph nodes and extranodal sites despite having distinct basic pathogenic mechanisms they share the cell of origin and molecular alterations clinical features and epidemiological characteristics however the influence of the crosstalk between tumor cells and the tme on the disease progression and treatment resistance remains poorly understood hindering the development of novel therapeutic possibilitiesthis study aims to uncover the intricate interplay between the tme and neoplastic cells in cll and mcl and exploit its therapeutic use to achieve this i will use singlecell rna sequencing and spatial transcriptomics to analyze the composition of nontumoral cells in tumorinvolved tissues and at different time points of the disease next i will use correlative analyses to identify the molecular and cellular interactions between the tumor cell epigenomic configuration and the tme determining tumor evolution and response to therapy finally i will validate the identified drivers of disease evolution and treatment resistance and examine their potential as a target for treatment using a 3d lnderived culture system the findings have the potential to provide a solid basis for establishing new models of patient risk stratification and identify potential therapeutic opportunities targeting interactions between tumor cells and their microenvironmentconducting this project at the molecular pathology of lymphoid neoplasms group of prof dr elias campo will provide me an opportunity to acquire essential technical and soft skills vital for advancing my career in research
epigenetic regulation of host factors in viral infections epivinf

the epivinf project aims to gain a deep understanding of how acute viral infections alter the epigenetic regulation of host factors that are critical for immune control and neurological health in particular epivinf will address how acute viral infections impact epigenetic control of host proteins that drive virusassociated disease andor are involved in the antiviral immune response and how such persistent epigenetic marks are related to longterm disease evolution epivinf will focus on two major human viral infections hiv and sarscov2 both pathogens that affect millions of people around the world and which despite wellknown differences share some intriguing features that demand further research we hypothesize that a defining individuals personal epigenetic profiles b assessing how they impact on the innate and adaptive immunity and c analysing epigenetic control mechanisms in two different viral infections hiv and sarscov2 will provide important insights into how different individuals react to different viral infections how different infections may share similar mechanism that impact on the long term health outcomes how these processes define the further disease course and finally how they could serve as targets for novel therapeutic interventionsto achieve these goals we will use an panel of cuttingedge epigenetic analyses immune monitoring tools diseaserelevant animal models samples from unique human vaccine trials and integrated biosystems analyses to gain a deep understanding of how viral infections harness epigenetic mechanisms to change the adaptive and innate immune phenotype of infected individuals not only during acute stages of the infection but potentially for live the study includes extensive patient followup to identify factors that predispose to different clinical symptoms and disease progression