Dragon09/odtu_chatbot huggingface dataset:
integrated interoperable smart and usercentred building automation and control system for better energy performance of nonresidential historic buildings coupling physics databased approaches

smarteestory will propose an integrated building automation and control systems for monitoring and optimizing building energy performance according to an innovative multidomain approach integrating sri domains hvac dynamic façade lighting ev incorporating historical building requirements as well as human requirements by envisaging realtime and active user engagement smarteestory system will automatically detect interacting with users via specific technologies identified in project early stages eg smart home systems the building users archetypes via drl algorithms therefore specific preferences smarteestory database of users archetypes and preferences in smart buildings energy demand comfort etc informing the optimization and control services such a system will encompass interoperable and cybersecure software cloudbased middleware provided with multiple services for monitoring digital twin analysis and prediction optimization and control embedding physics and databased models for forecasting building energy performance and using digital building logbook as a common data environment and hardware advanced edge computers multiprotocols data gateways smart and automated sun blinds smart sensors and actuators for technical building systems integrated control according to occupancy and energy efficiency needs smart products for user engagement solutions fully enabling the three functionalities required for a building to become smart i optimization of operation of technical building systems ii adapting to the external environment including energy grids changing condition in relation to demands from building occupants the system will be deployed at trl 8 in three demo sites nonresidential historic buildings identified in latvia spain and the netherlands to demonstrate buildings improved energy performance in correlation to the increased smartness rating
international finance and the great powers 18002020

the world is entering a new era of great power rivalry with the rise of china and the russiaukraine war being only the most visible signs this proposal asks what are the implications of these developments for global finance will chinas rise accelerate financial globalization or rather reverse it what do the growing tensions between great powers imply for financial markets around the world and what motivates china to invest trillions of dollars of state funds into its belt and road initiative bri it is difficult to answer these questions because major shifts in the international order occur only every few generations we therefore need to look back but existing research in international finance mostly relies on evidence since the 1970s from an era dominated by the us and in which states had limited influence on capital flows as a result our knowledge on the role of state power in global finance is limited more generally the literature on geopolitics and international economics is still in its infancy with this proposal i want to fill these gaps i use theory rigorous empirical methods and comprehensive new data to study how the rise and fall of great powers or geopolitics shaped global investments over the past 200 years in part one i embark on a major data gathering effort on northsouth capital flows and investor returns at a microlevel covering tens of thousands of individual bonds stocks and infrastructure projects since 1800 in part two i use this comprehensive new data to analyse 1 how changes in the international balance of power influence the global allocation of capital 2 how geopolitical shocks such as wars affect investor returns in the short and long run and 3 whether and how rising powers use infrastructure investments as a strategic tool to extend influence abroad in particular to advance their energy security access to scarce raw materials and for military control
the role of arbuscular mycorrhizal fungi in agricultural grasslands exposed to increasingly persistent weather patterns

a recent fingerprint of climate change is the increasing persistence of weather patterns whichimplies that average weather is making way for anomalously long periods of dry or wetmeteorological conditions this shift in climate regimes is likely to negative affect ecosystemfunctioning yet scientific knowledge on this is still scarce as much research has focused onunidirectional changes eg only an increase in dry periods in the current project we will fill part ofthis knowledge gap by studying impacts of increasingly persistent weather in agricultural grasslandsusing a stateoftheart experimental platform we will test how a sequence of dry wet oralternating dry and wet growing seasons affects grasslands relevant in flanders and whether plantcommunity composition which grasses are present in which numbers can modulate the outcomefurthermore we will evaluate the importance of arbuscular mycorrhizal fungi amf in potentiallyaltering impacts of increasingly persistent precipitation regimes identifying amf colonization inrelation to plant performance and how amf regulate biochemical and molecular pathways in differentgrassland species the un has recently called for more attention for naturebased solutions in thefight against negative climate change impacts this project contributes to that by elucidating theimportance of plant community composition and amf in safeguarding grassland ecosystemfunctioning under increasingly persistent weather
source to seas zero pollution 2030 soszeropol2030

the overall aim of source to seas zero pollution 2030 soszeropol2030 is to develop a holistic zero pollution framework which can guide the process towards achieving zero pollution in european seas by 2030 marine contamination including pollution occurs as a direct result of human activities on both land and in the marine environment and requires urgent attention as healthy and clean seas provide numerous ecosystem services eg food oxygen production climate regulation which are critical for our survival and wellbeing given the complex and interconnected nature of marine pollution the integration of sustainabilityfocused agendas and circular economy principles and practices is essential for the development of effective actions that can address its impacts the implementation of processes and measures to reduce marine pollution will have consequences for numerous economic sectors eg agriculture fisheries food and beverage industry waste management packaging industry tourism offshore energy at multiple scales local national regional and international framing marine pollution as a considerable global socioeconomic challenge that requires active collaboration from multiple stakeholders across a range of geographic areas in this context soszeropol2030 aims to codesign coproduce and codeliver a stakeholder lead european seas zeropollution framework that provides practical guidance from source to sea addressing shortcomings in marine pollution management and governance this holistic approach is based on best practice puts emphasis on human behaviour socioeconomics and governance and is underpinned in knowledge about and understanding of current barriers to effective and efficient prevention reduction mitigation and monitoring of marine pollution in european seas
the role of the noncanonical death receptor signalling in cancer and immune cells

immune surveillance refers to the ability of the immune system to efficiently induce cell death apoptosis in aberrant cells during the early stages of tumour development this induction of cell death involves the binding of the death ligand trail tnfrelated apoptosisinducing ligand to its death receptors drs dr4 and dr5 on the target cell however tumour cells can escape this immune surveillance by switching the signalling downstream of drs from the canonical proapoptotic signal towards a survival signal previous work from chiron partners highlights that this noncanonical drsignalling regulates both tumour cell behaviour and immune cell functions demonstrating its central role in understanding the tumour microenvironment yet many aspects of the drsignalling pathways remain unresolved hampering the exploitation for diagnostic and therapeutic purposes chiron will address these gaps via its main scientific aims i to develop novel small molecule inhibitors smis to inhibit noncanonical drsignalling wp1 ii to identify new dr4 and dr5binding partners within tumour and immune cells wp2 and iii to gain a mechanistic understanding of the role of the noncanonical drsignalling pathway in immune cells and cancer types wp3 to achieve this the chiron consortium combines the multidisciplinary and complementary expertise and resources of six academic and three private sector partners to i generate novel knowledge and innovative tools ii strengthen an efficient network of knowledge exchange for further innovative synergies and iii develop the expertise of earlystage and experienced researchers through excellent training the outputs of the research will i develop novel tools to sensitise tumour cells for trailinduced cell death ii guide future diagnostic and therapeutic strategies to utilize and modulate drsignalling and iii train the expertise necessary to turn such knowledge into innovative services and products
festival der wissenschaft kiel region 20222023

successfully launched in 2016 the hugely popular european researchers night will return in 202223 to the kiel region as a true science festival with a much greater scope in terms of geography duration and activities not only will it bring together all of kiel regions 12 research organisations comprising all academic disciplines showcasing their scientists and work to the public but will also include for the first time activities organised by researchers from denmark and the european university of the seas seaeu another novelty will be an extended programme of preevents as well as the school programme with rentascientist and rentasciencefilm formats across the regions five major cities kiel rendsburg eckernförde plön preetz this will enhance awareness of the project and its messages and likely attract up to 20000 visitors each year finally the night will offer for the first time both online and inperson formats to include more researchers to reach an even wider audience and to increase the longterm impact by making recordings available after the event science4future will focus on the themes of sustainability digitality and europe a more sustainable approach to the environment the economy and society supported by researchbased digital innovations is the prerequisite to a prosperous future in europe and our activities will each be associated with at last one of the horizon europe missions with the support of over 40 german and danish institutions the active involvement of over 300 researchers in the design and delivery of the programme and partners from seaeu as well as the public private and nongovernmental sector science4future thus establishes itself as the only crossborder night and the largest public event dedicated to sciencecommunication and scienceeducation in northern germany
augmenting participation cocreation trust and transparency in deliberative democracy at all scales

orbis addresses the disconnects between ambitious ideas and collective actions at a large sociotechnical scale it responds to the profound lack of dialogue between citizenship and policy making institutions by providing a theoretically sound and highly pragmatic sociotechnical solution to enable the transition to a more inclusive transparent and trustful deliberative democracy in europe the project shapes and supports new democratic models that are developed through deliberative democracy processes it follows a socioconstructive approach in which deliberative democracy is not a theory which prescribes new democratic practices and models but rather the process through which we can collectively imagine and realize themorbis provides new ways to understand and facilitate the emergence of new participatory democracy models together with the mechanisms to scale them up and consolidate them at institutional level it delivers i a sound methodology for deliberative participation and cocreation at scale ii novel aienhanced tools for deliberative participation across diverse settings iii a novel sociotechnical approach that augments the articulation between deliberative processes and representative institutions in liberal democracies iv new evidencebased democratic models that emerge from the application of citizen deliberation processes v demonstrated measurable impact of such innovations in realworld settingsthe project builds on cuttingedge ai tools and technologies to develop a sustainable digital solution and bridges theories and technological solutions from the fields of political and social science social innovation artificial intelligence argumentation and digital democracy the achievement of the projects goal is validated through six use cases addressing contemporary issues at different scales and settings experimenting with different civic participation and deliberation models and involving diverse types of stakeholders
towards the sustainable gigafactory developing green cell manufacturing processes

the eu has established an ambitious industrial goal to make europe a strategic global leader in the liion battery value chain deploying a sustainable and innovative industry this urges the sector to make sure that the industrial production is inherently sustainable safe flexible and costeffective while delivering cutting edge cells the main objective of gigagreen is to boost the next wave of electrode and cell component processing techniques enabling breakthrough innovations to improve the environmental economic and social performance of generation 3b liion cells manufacturing industry thus positioning europe at the forefront of the global marketgigagreen proposes a structured research plan to develop and scale up trl 34 to 56 novel electrode and cell component manufacturing processes that follow a design to manufacture dtm approach this is seeking for the minimum environmental impact and energy consumption cell designs which facilitate the reuse and disassembly increasement of the costefficiency and safety of processes and products and highthroughput technologies able to be easily scaled up and automated in the context of industry 4050 gigafactories supported by a vibrant and experienced consortium of academic and industrial partners gigagreen will follow two alternative ri trajectories the first one based on nmethyl2pyrrolidone nmpfree wet processing is designed for a quick scale up and market uptake of optimised wet coating systems in current industrial setups final trl6 30 cells of 10 ah prototyped as demonstration the second one based on dry processing will explore breakthrough technologies achieving a smaller trl by the end of the project final trl5 3040 mah monolayer pouch cells prototypes as proof of concept paving the path for upcoming ri experiences to continue scaling up the most promising dry processing techniques
aidriven cardiac ultrasound analysis

heart ultrasound is the most versatile most widely used and costeffective heart imaging method accessibility to ultrasound imaging is growing rapidly as the devices are getting cheaper and smaller however interpretation of the acquired images creates a bottleneck it requires substantial skill it is long manual and prone to errors and variability ligence is remodelling the quality difficulty and length of echocardiography with an aidriven tool to automate the whole analysis of heart ultrasound images deep learning neural networks classify heart image views detect heart cycle phases and perform measurements it seamlessly integrates with existing infrastructure in hospitals meaning that moments after images are loaded onto the hospitals network the results are accessible on any workstation this results in dramatically increased accessibility and analysis quality earlier diagnosis and better patient risk stratification monitoring and patient management
pantarhei gas flows in galaxies at cosmic noon

the formation and evolution of galaxies over cosmic time is driven by the continuous flow of gas in and out of systems known as the baryon cycle current theoretical models suggest that feedback from star formation sf and active galactic nuclei agn leads to gas outflows regulating sf activity and enriching galaxy metal content this ejective feedback is believed to be particularly powerful at z12 during the peak of sf and agn activity known as cosmic noon yet a comprehensive understanding of gas outflows at z12 remains elusive the pantarhei project hosted at sns seeks to fully characterise the galaxy baryon cycle at cosmic noon using a unique approach i build the largest highresolution r3000 opticalrestframe spectroscopic sample to date by combining new data from subarufmos with exclusive access and public archival data from vltkmos totallin 7600 galaxies at z12
evasion of antitumor immunity and immunotherapy by melanoma extracellular vesicles

melanoma is the deadliest of the skin cancers immune checkpoint inhibitors ici which are blocking antibodies that help to restore antitumor immunity are currently used for the treatment of metastatic melanoma however only approximately 20 of the patients respond to ici understanding the molecular mechanisms behind the resistance to these therapies is essential to predict patients response and increase treatment success extracellular vesiclesevs nanosized structures released by virtually all cells are key mediators of cellcell communication and horizontal transfer of biomolecules locally and systemically evs are known to play an important role in cancer biology by regulating cell apoptosis angiogenesis antigen presentation and immune modulation in recent years evs have been shown to also act as proteindecoys through binding and sequestering soluble proteins thus preventing proteintarget interactions previous work from the host group shows that evs excreted by melanoma cell lines express interferon receptor ifngr thus we hypothesize that melanomaderived evs modulate the bioavailability and activity of this cytokine preliminary results show that evs isolated from mouse metastatic melanoma b16f10 cells express ifngr bind to ifn and protect tumor cells from the cytotoxic effect of ifn because resistance to antitumor immunity and to ici has been linked to defects in ifn signaling this project aims to investigate whether ifngr evs downregulate ifn signaling and ici response this research has the potential to unveil a novel yet overlooked cancer immune evasion mechanism mediated by ifngr evs which may provide crucial insights to optimize current cancer therapies and ultimately improve patient outcomes
sustainable money

the next generations will not need a money designed for infinite longterm economic growth but a sustainable money designed for managing limited and fragile common pool resources and able to support sustainable development and environmental protection sustainability studies developed in many areas of research while in the field of money research there are ongoing studies for the sustainable allocation of financial capitals but not for a sustainable money design regulation and functioning susmoney research will cover this gap providing 1 a new framework for the study of the characteristics regulation and functioning of a sustainable money 2 a classification of the sustainable dimensions of the european experiments of monetary innovation 3 an empirical study on chiemgauer complementary currency to assess whether this type of money can support a sustainability transition susmoney is a novelty in the panorama of the sociology of money economics and sustainability studies because for the first time money is studied in the light of a general theory of sustainability related to politics economics ecology and culture and with a mixedmethod research design the use of the social mechanisms approach is also a novelty in money studies results will provide knowledge useful for the replication of monetary experiments with sustainable aims in different contexts susmoney will open a new field of research and offer also crucial information for the policy debate for a new sustainable money the hosting institution is trier university with the supervision of prof andrea maurer an internationally renowned expert in the field of economic sociology and social mechanisms the secondment will take place at the max planck institute for study of societies in cologne with the supervision of the director prof jens beckert a prominent international scholar on the field of economic sociology and the study of money
rewire the lymph node niche to instruct t cell immunity

lymph nodes ln are communication centers within the lymphatic network that instruct t cell priming and differentiation in homeostasis and disease multiple layers of control are achieved by a complex network of signals from stromal and immune cell compartments as a result spatially segregated ln niches coexist that foster diverse t cell lineages in the context of cancer t cell differentiation is pushed towards the lineage of exhaustion with a progenitor exhausted t cell population arising in the ln hence ln are central anatomic sites where t cell exhaustion can be controlled and reversed to eliminate cancer the key question of rewire is what microenvironmental factors determine the differentiation and maintenance of progenitor exhausted t cells in the lntumorderived signals reprogram stromal and immune cells within tumordraining ln thus a premetastatic niche is formed that supports future metastatic seeding while establishing an immunosuppressive microenvironment i hypothesize that signals guiding t cell differentiation are altered by premetastatic remodeling of the ln niche resulting in the generation of exhausted t cellsin this project i aim to 1 decode spatial determinants of the progenitor exhausted t cell niche and to 2 manipulate the tumordraining ln ecosystem to control t cell immunity the overarching goal is to dissect how tissue architecture directs molecular responses within the ln niche to regulate t cell exhaustion we will use highdimensional imaging technologies to chart the spatial context of progenitor exhausted t cells following tumor progression as well as a novel myeloid cellbased in vivo delivery platform to specifically target tumordraining lnrewire will uncover basic mechanisms of communication between the ln microenvironment and differentiating t cells in the ln as well as explore the novel concept of controlling t cell responses via manipulating keyfeatures of the ln niche