Dragon09/odtu_chatbot huggingface dataset:
extremeultraviolet metaoptics for attosecond microscopy

extreme ultraviolet euv light sources have matured both in brightness as well as in producing ever shorter attosecond light pulses contrary transmissive euv optics remain sparse due to material absorption thus euv microscopy today focuses mainly on lensless techniques or secondary observables such as photoelectrons euvoram extremeultraviolet metaoptics for attosecond microscopy will experimentally demonstrate that metaoptical devices are realizable in the euv using a novel design approach and that they can solve the current lack of transmissive euv optics by emulating the spatial phase profiles of aspheric lenses we will fabricate focusing metaoptics yielding neardiffraction limited microfoci in the euv in combination with contemporary attosecond pulse sources based on laserdriven highharmonic generation these metalenses will enable highnumericalaperture euv focusing that maintains attosecond pulse durations euvoram will exploit this capacity to build a light microscope that unifies attosecond time and nanometer spatial resolution after its demonstration we will apply this microscope to isolate the ultrafast hot electron dynamics and subnanometer charge transfers in individual plasmonic coreshell nanoparticles using spatially resolved attosecond transient absorption spectroscopyeuvoram will be one of the first projects connecting attosecond science and dielectric metasurfaces the planned euv metaoptics and their novel design will undercut the current shortwavelength limit of metasurface optics by a factor of four and thus directly redefine the stateoftheart the project will push lensbased microscopy to unprecedented time resolutions and at the same time allow hyperspectral attosecond imaging the latter will free attosecond experiments from observing ensemble averages and provide spatially resolved insight in the lightmatterinteraction of photonic nanodevices
eyetracking and ai for enhanced teaching

eyetracking and ai for enhanced teaching eyeteachrecent education assessments pirls pisa show a significant decline in reading comprehension amongst students in many european countries the eyeteach project is an initiative integrating artificial intelligence ai and eyetracking et that aims to transform educational practices and empower european teachers with new pedagogical skills for assessing and supporting their students reading comprehension the project addresses issues such as the postcovid19 educational challenges mounting teacher workload and teacher shortages across europeeye tracking although not without limitations has proven its worth in educational research offering insights into students reading behaviours cognitive load and emotional engagement it differentiates between various levels of reader comprehension making it a valuable tool for personalised education complex eyetracking data translated into intelligible output by ai and supported by a robust ethical and data privacy framework can provide teachers with actionable insights aiding the selection of effective pedagogical strategies eyeteach reaches beyond the state of the art by involving teachers and education practitioners early in the development process by mapping educators acceptance and readiness to adopt such novel technologies and highlighting the role of perceived ease of use and usefulness the project has real potential to transform educational practices the final joint result of the project will be a comprehensive resource of training materials and guidelines for using and implementing this technology in education including benefit and risk assessments and considerations of privacy and ethics issues by empowering teachers with an aiassisted etanalytics tool and training materials the project aims to contribute positively to the future of education in europe
structural reliable offshore floating pv solution integrating circular concrete floating breakwater

surewave will develop and test an innovative concept of floating photovoltaic fpv system consisting of an external floating breakwater structure acting as a protection against severe wavewindcurrent loads on the fpv modules allowing increased operational availability and energy output thus unlocking the massive deployment of offshore fpv it will be focused on the research for securing optimal behaviour at aero hydrodynamic and structural integrity level of the external breakwater the internal fpv modular structure the connections the mooring and anchoring and the whole fpv system complying with mechanical electrical maximizing energy output and costefficiency requirements ensuring high lifetime of critical components high reliability of the system and easy quick and costefficient construction installation and om of the whole systemthis will require1 the development of novel circular concrete material solutions for the breakwater costeffective easy to produce and with high mechanical physical and durability properties and low co2 footprint2 the development of an advanced predictive computational modelling and simulation framework coupled aero hydrodynamic modelling structural integrity modelling material properties modelling and structural health management to reduce capex and opex3 the design and implementation of an optimal testing and validation methodology for offshore fpv system to achieve trl5 including lab testing basinmodel testing and marine environment testing of critical components assuring high resilience to corrosion and biofoulingmaximum advantage of existing expertise will be taken from experts in offshore wind floating structures material and phenomena modelling sintef marin ceit design and installation of fpv in calm waters sis floating solutions clement circular structural and nonstructural materials acc and in social environmental and economic assessment ifeu
statisticsdriven planet imaging in circumstellar environments

the spices project applies and develops stateoftheart statistical methods to image forming exoplanets and characterize planetforming disks more than 5000 exoplanets have been detected as of today showing a great diversity in planetary system architectures that is still not entirely understood many of these planets were found in systems that have dissipated their birth environment and do not allow for the study of the early times of planet formation originally formed in gaseous protoplanetary disks surrounding newborn stars longperiod giant planets such as jupiter shape the evolution of planetary systems including that in our own solar system they can gravitationally interact with disks and imprint signatures such as gaps rings and spiral arms such features are routinely observed in high resolution disk observations suggesting that a large population of massive planets are actively sculpting protoplanetary disks later on these gasrich disks dissipate within a few myr while terrestrial planets form and planetesimal collisions lead to second generation dust populations ie debris disks observation of planetary systems in different stages is therefore key to understanding their formation and evolution using modern statisticsbased methods i propose the statisticsdriven planet imaging in circumstellar environments spices project to perform unprecedented inspection of planet forming disks thus detecting planets that are embedded in disks while characterizing disk mineralogy by doing so i will bridge the gap between revolutionary data analysis methods in analyzing and the myriad of highquality data and ultimately provide new insights into the formation and evolution of planetary systems
contested knowledges in and through asylum litigation

migration and particularly the question of asylum has become one of the most pressing and polarizing issues of our time scholars have highlighted how the high level of contestation and politicization in this area has increased the demand for a wide range of expert knowledge at the same time this situation has thrown expert knowledge into a terrain of conflict consequently the notion that expert knowledge provides a proper foundation for legal decisionmaking regarding asylum is under pressure asyknow will develop new conceptual tools for understanding the role of expert knowledge in asylum governance by investigating the ways in which knowledge about asylum seekers and migration is constituted and contested through asylum litigation the project moves beyond traditional approaches to expert knowledge in migration scholarship which has largely examined the content of decisions and adopted a onedirectional approach to expert knowledge as an instrumental andor symbolic tool of states domination instead a focus on asylum litigation allows us to examine 1 how knowledge claims attain meaning and authority through the relational dynamics between differently situated actors 2 how legal thresholds and tactics evolve as they pertain to the use of expert knowledge and 3 how types of knowledges and knowledge claims facilitate or challenge states ability to exercise power over bodies and spaces asyknow brings together theoretical concepts methodological approaches and findings from geography anthropology law and science and technology studies sts that have hitherto remained fairly separate with regard to the study of migration into a novel and productive dialogue methodologically the project adopts an ambitious indepth comparative research design that innovatively combines an ethnography of legal processes with legal archaeology empirically the research will focus on litigation of asylumrelated cases in norway sweden denmark and germany
rebellious youth movements and alternative music cultures and intersectional critique in poststate socialist poland 1977 1995

rebyouth main objective is to explore an entirely new area of research by focusing on the largely overlooked histories of women queer black and people of colour wqbpoc in rebellious dissident youth movements and alternative music cultures from the late 1970s of late state socialism to the early 1990s in poland the focus is on cultural heritage dissidentcultural practices infrastructures of support and collisions with dominant social cultural and political regimes objectives are the 1 mapping of wqbpoc dissidence history and cultural heritage with focus on music in the broader context of independent culture 2 exploring public and private archives 3 capturing and analyzing life time biographies and oral history accounts of wqbpoc actors 4 empowering wqbpoc through inclusion into contemporary historical discourses and memory practices 5 analysing intersectional dissidence and collisions of sensible orders and developing a concept of intersectional critique 6 investigating infrastructures of support 7 mapping and analyzing international connections transfer and migration the main empirical research methods include research in private and public archives and qualitative interviews with a series of life history interviews tracing selected biographies in changing sociopolitical contexts and during migration the mapping of projects people crews networks events and artefacts will be an ongoing process resulting in visual maps based on a crosscutting analysis of biographies infrastructures of support and social positioning situational maps will be created
exploring the molecular imprint of microbeinduced plant resistance in plantassociated communities

plantbeneficial microbes can modulate the plant immune system enhancing plant resistance to insect pests this phenomenon known as microbeinduced plant resistance mir has emerged as a sustainable pest control strategy strikingly my latest results indicate that mirimmune responses elicited in plants cascade upwards leaving a molecular imprint in surviving insect herbivores a mirimprint this suggests that mirtriggered responses in plants could travel beyond the plant and be incorporated into plantassociated communities however inclusion of the effects of mirelicited responses across different members of the trophic chain from plants to herbivores their natural enemies and the soil microbiome has been neglected in mir researchthe overall goal of mimir is to unravel how and to what extent mir immune responses triggered in plants are transduced and incorporated in plantassociated communities mimir will use a multidisciplinary approach combining multiomics highthroughput techniques computational biology functional genomics and mesocosm experiments to address three main challenges 1 disentangling molecular regulation of the onset and functioning of the mirimprint in insect herbivores 2 unravelling how and to what extent the mirimprint crosses to the third trophic level natural enemies and its impact on species interactions and 3 deciphering how and to what extent mir imprints the rhizosphere microbiome generating a soil mirmemory with impacts on aboveground insectsmimir will foster a detailed understanding of how mirtriggered responses travel from the plant to plantassociated communities and to what extent they are incorporated into the agroecosystem launching the field into new and exciting directions in a broader context mimir will provide multiple crucial insights into the fundamental question of how species interact in complex systems a question of high relevance for the global challenge of food security
revolutionizing dfu treatment escharex a gamechanging solution

introduction mediwound develops wound care solutions for chronic wounds and severe burns the companys leading drug candidate under development and the subject of this eic accelerator project is escharex a groundbreaking bioactive therapy specifically targeting the debridement of diabetic foot ulcers dfus and other challenging chronic wounds escharex is poised to revolutionize the standard of care soc that for many patients is ineffective escharex a gamechanger in chronic wound care escharex is a complex mixture of proteolytic enzymes primarily bromelain designed to selectively remove necrotic tissue and biofilm from chronic wounds this process is highly efficient and does not harm viable tissue providing an optimal wound bed for healing unlike traditional knifebased debridement which can be traumatic and painful escharex offers a nonsurgical alternative that is swift safe and effective this aspect is especially critical for diabetic patients often elderly and suffering from comorbidities who may find surgical options less suitable the currently available nonsurgical options are notoriously slow and ineffective causing delays to the wound healing process and resulting in significant incremental costs and poorer overall outcomes clinical progress and validation mediwounds confidence in escharex stems from the outcomes of three phase 2 clinical studies these studies demonstrated the therapys rapid safe and effective debridement of dfus and venous leg ulcers vlus additionally escharex shares the same active pharmaceutical ingredient as nexobrid mediwounds ema and fdaapproved drug product for debridement of severe burn wounds the consistency of active ingredients and similarity of indications between these two drugs provides additional support for the increased probability of success for escharex development and highlight the scientific rigor behind escharexs development
impetus4change i4c improving nearterm climate predictions for societal transformation

impetus4change i4c will make significant scientific advances that will enhance our collective ability to act on and adapt to nearterm climate change the overarching objective of i4c is to improve the quality accessibility and usability of nearterm climate information and services at local to regional scales where impacts are most keenly felt and ontheground adaptation is implemented to strengthen and support enduser adaptation planning and action several specific objectives work towards this overarching goal 1 improve understanding and flow of climate information through knowledge networks
validation of synuclein modifications in parkinsons disorder evolution

parkinsons disease pd presents a complex challenge due to its progressive neurodegenerative nature affecting various body systems despite decades of research understanding its onset and progression remains unclear complicating early diagnosis and treatment recent advancements in pd physiopathology suggest promising treatments to slow disease progression yet reversing cellular degeneration remains elusive with novel therapies emerging the need for early detection tools is urgent however validated biomarkers for pd diagnosis are lacking relying on subjective scales like hoehn and yahr or costly medical imaging techniques the accumulation of misfolded synuclein syn proteins in pd pathology has sparked interest but defining diagnostic roles requires further investigation recent findings of syn in neuronalderived extracellular vesicles ndevs from pd patients suggest a potential for novel diagnostic methods our proposed project vmpire aims to conduct a longitudinal study involving 600 pd patients and 600 healthy subjects to explore syn isoforms and related biomarkers in ndevs for early pd detectionwe plan to develop and validate an innovative invitro diagnostic ivd test capable of detecting pds earliest stages and estimating disease prognosis and progression utilizing ai models to generate data analysis algorithms and collaboration with leading analytical laboratories and ivd manufacturers we aim to ensure the reliability and feasibility of the developed prototype through consortium efforts we envision licensing the generated intellectual property to drive the commercialization of our results this can improve early screening of 270000 new cases of pd could be detected early and improve the disease management of 94 m people currently diagnosed of pd and avoid losing a total of 58 million disability adjusted life years dalys by 2028 leading also the development of better treatments
pathways for cocreation between local authorities and collective actions for a sustainable transition

in western democracies traditional institutional participation is on the decline while noninstitutional participation has been increasing noninstitutional participation for the climate transition often relies on a prefigurative approach thus creating spaces to incubate alternative ideas and novel forms of political participation niches empowering these forms of political participation to encourage niche innovations will provoke the radical yet necessary changes in the sociotechnical system for a climate transition the cosustain project seeks to address this opportunity for a democratic climate transition by defining and testing new democratic pathways enabling local policymakers to support various and novel forms of political participation and empowering citizens to act for a sustainable transition to develop a better understanding of political participation linked to environmental political and societal imperatives cosustain will study 18 historic examples in 6 different european countries for each of the latent and manifest forms of political participation underlined by ekman involvement civic engagement formal political participation and activism it will use institutional ethnography and system mapping to understand the dynamics of the participation and its management thus delivering best practices to stimulate and support political participation around these imperatives these best practices will serve to define interventions for solution cocreation in 4 case studies one for each form of political participation involvement through spanish energy communities civic engagement through food solidarity in turin it manifest political participation through participatory processes promoted by the government in northern europe ee fi and activism through the lobau bleibt social movement at the outputs and outcomes of the deliberations will be assessed to draw conclusions for more democratic climate policymaking across europe
development and characterization of a panflavivirus vaccine candidate

dengue yellow fever zika and west nile viruses are mosquitoborne flaviviruses and global public health burdens that infect half a billion people annually causing 250000 deaths and threaten nearly the entire human population in a context of humandriven global changes these threats will intensify with larger and more frequent epidemics potentially leading to pandemics will expand with geographic spreading of the mosquito vectors and will multiply with the likely emergence of yetunknown flaviviruses improving pandemic preparedness and response to these emerging and reemerging diseases is a top priority both for the eu and who however there are no effective interventions against all flaviviruses and current vaccines targeting flaviviral proteins have severe safety issues flavivaccines highimpactlowriskdisruptive ambition is to develop a novel broadspectrum mosquito salivatargeted vaccine candidate that protects against multiple different flaviviruses and is ready for clinical evaluation by building upon an experimentallyvalidated proofofconcept flavivaccine will define the immunogenicity of the panflavivirus target develop and characterize a vaccine candidate against multiple flaviviruses and prepare it for clinical evaluation to reach these goals flavivaccine creates a unique interdisciplinary environment of ten public and private institutions including universities research institutions and a vaccine developer from seven countries to cover all the required scientific expertise and knowledge in cell biology virology immunology and vaccinology the panflavivirus vaccine candidate that will be validated against dengue yellow fever zika and west nile diseases in several preclinical models together with the knowledge and networks resulting from flavivaccine will have short and longterm impact on the eu ability to combat epidemic and pandemic viral threats and protect communities and citizens in the eu and around the world
resilient and adaptive supply chains for capabilitybased manufacturing as a service networks

the past years have shown the vulnerability of rigid international supply chains the ability to adapt to changes and create resilient supply chains will be a key competitive advantage for manufacturers in the future raasceman tackles three different possibilities to react to unforeseen eventsadapting the production plan based on supply chain dataadapting the supply chain by switching the supplier using a maas networkintegrating remanufacturing as procurement alternative leveraging circularitythe project aims to enable companies to mitigate short and mediumterm unforeseen events and to enable companies to participate in a dynamic maasnetwork lowering the market barriers for companies specialized in remanufacturing or alternative technologies such as 3d printingraasceman designs and demonstrates a series of software tools digitizing supply chains by using digital twins and an infrastructure for dataexchange based on european values raasceman will develop its overall ambition by the means of five scientific objectives namelyactionable propositions for adapting supply chains or internal production and logistics based on reliable quantification and impact prediction of unforeseen eventsdynamic supply chain generation enabling resilience and selfadaptation of maas networksbuilding trust in maas networks auditing suppliers reliability and testing plausibility of offersdynamic planning and scheduling of production processes enabling companies to swiftly adapt logistics and production to varying external conditions anddynamic assembly and disassembly to enable machines in the field levelwe demonstrate our solutions in two industrial usecases of the automotive and bike industry and create a maas network connecting five pilot lines distributed over europe the majority of project results will be made available under appropriate opensource licensing schemes to allow further maturation in integration after the raasceman project concludes