Dragon09/odtu_chatbot huggingface dataset:
noninvasive patterned electrical neurostimulation of the retina

retinal implants remain one of the most demanding technologies in brainmachine interfacing state of the art devices have yet to reach the needed performances main barriers are suboptimal stimulation parameters and long development and testing procedures while invasive approaches have yet to achieve the resolution performances needed by million of patients blinded by retinal degenerative diseases noninvasive approaches in the form of transorbital stimulation have received no attention yet they offer potentially dramatically cheaper and easy to adapt and optimize technology the main goal of this project is to advance the field of retina neurostimulation by developing new tools for the study and interfacing with the retina in particular 1 bidirectional electrophysiological interface which can record and stimulate the intact retina in the eye and 2 soft multielectrode arrays for noninvasive stimulation of the retina soft transorbital electrodes will be explored we will use these tools to study the retina in its intact form in animal models and we will implement the gained knowhow in humans to study noninvasive stimulation in this project we will establish a new platform for bidirectional electrophysiological interfacing with the intact retina and we will use it to study the retina in its intact form such investigations have ground breaking nature as they can advance both the fundamental understanding of the retina and improve the manner by which we stimulate the retina to generate artificial vision specifically we aim to record spontaneous waves activity and light sensitive ganglion cells optimize electrical stimulation parameters in the intact retina and ultimately to measure retina responses to transorbit stimulation as the ultimate goal of the project we aim to establish the foundation of transorbital stimulation as a new noninvasive paradigm for functional vision in patient suffering from retina degenerative diseases
showcasing advanced hydrogen valley in western france

advancedh2valley aims to accelerate the deployment of renewable hydrogen in the loire valley in france by 2025 and prepare the future largescale hydrogen economy in the european atlantic coastline the project is built on successful first achievements of h2ouest and vhygo valle hydrogne grand ouest two hydrogen ecosystems initiated in 2019advancedh2valley is taking a big step forward in accelerating renewable hydrogen deployment in western france as it will initiate115mw of new production capacities along with innovation to optimize operation process representing 1600t 100 certified renewable h2year by 2028 in line with the delegated act of the eus renewable energy directive2 new hrs with distribution capacity of up to 13tday on rtet network1st hydrogen trucks fleet deployment in france as well as innovating offroad port logistics vehicles and river ferry1st renewable hydrogen supply chain adapted to industrial customers specific requirements in order to quickly decarbonize even the small industrial hydrogen consumptionsinnovations to enhance valley operation multisites coordination optimised truck fillingadvancedh2valley ambitions to be both a lighthouse and an innovation lab for hydrogen valleysthe consortium will strengthen collaborations and synergies between neighboring regions and especially pioneering peripherical maritime regions of the atlantic arc the partners will actively share to them the knowledge generated on the project to foster the scalability and replicability of the advancedh2valley model and to pave the way for the future largescale hydrogen economy in europethe main expected impacts of the project are the direct decarbonization of transport and industrial activities using renewable hydrogen 146t of co2 will be avoided during the 2year operation and 28mt per year by 2036
development of dualtargeting epigenetic modulators for polypharmacologybased cancer therapy

cancer is a multifactorial disorder involving different genetic and epigenetic alterations since epigenetic modifications are brought about by multiple enzymes working synergistically multitargeting compounds may be particularly effective to acutely interfere with aberrant processes the simultaneous inhibition of two or more enzymes by a single molecule provides improved therapeutic efficacy compared to singletarget inhibitors along with reduced insurgence of drug resistancethrough this project i aim at developing novel therapeutics targeting protein demethylation and deacetylation for application in cancer therapy i will synthesise and evaluate hybrid molecules inhibiting two enzymes at the same time i will develop two classes of compounds targeting the lysinespecific histone demethylase 1a lsd1 and either protein arginine nmethyltransferase 5 prmt5 or histone deacetylases 12 hdac12 these enzymes cooperate in different pathways that lead to cancer insurgence and progression hence dual targeting represents a successful strategy to counteract tumour growthto achieve the outlined aims i will employ a multidisciplinary approach requiring the fusion of knowledge and tools from medicinal chemistry biochemistry biophysics molecular and cell biology through the employment of cuttingedge synthetic approaches i will prepare lsd1prmt5 and lsd1hdac12 inhibitors which will be assessed through multiple biochemical and biophysical assays i will also employ native mass spectrometry to investigate their mode of action in the context of the multiprotein complexes formed by the protein targets the most promising inhibitors will be evaluated in cellular assays to assess their anticancer properties and their effects on transcriptional regulationthis project will open innovative avenues for personalised therapies and provide additional weapons to overcome drug resistance along with adding new knowledge on the epigenetic mechanisms of cancer
engineering safe faba beans by targeting the antinutrients vicine and convicine

faba bean is a highyielding protein crop well adapted to cold climates its seeds contain large amounts of protein antioxidants and micronutrients making it an ideal crop to support the transition toward a plantbased diet however faba bean seeds also accumulate high levels of the antinutritional alkaloids vicine and convicine these alkaloids cause hemolytic anemia favism in individuals with a genetic deficiency g6pd deficiency occurring in 5 of the world population faba bean varieties with reduced levels of vicine and convicine exist but the residual levels are variable causing concern for the food industry the development of varieties devoid of vicine and convicine has been hampered by a lack of genomic resources and insufficient knowledge about their biosynthesis in the cleanbean project i will team up with prof fernando geuflores from the department of plant and environmental sciences of the university of copenhagen i will use recently generated resources to uncover the full vicine and convicine pathway and create faba bean lines devoid of these antinutrients the proposed work involves gene selection through coregulation association strategies pathway elucidation using in vitro and in vivo assays and pathway inactivation in faba bean using the recently published findit technology nongmo the impact of cleanbean will be multifaceted spanning both fundamental and applied research on the basic science side the project will uncover the complete pathway of a nucleotidederived specialized metabolite from plants for the first time on the applied side the project will lead to the creation of a vicine and convicinefree faba bean thus enabling the safe consumption of faba beans by all individuals and helping transform the landscape of sustainable food production
searching new physics using flavour

after ten years from the discovery of the higgs boson at cern which established the standard model sm of particle physics as the most accurate description of nature at its fundamental level no direct sign of new physics np beyond the sm has been observed in order to make further progress in highenergy physics it is necessary to improve the precision of theoretical sm predictions and search np effects indirectly by looking for tiny discrepancies with experimental measurements this proposal will make use of a combination of formal and numerical tools in particular methods of numerical lattice quantum chromodynamics qcd to achieve this aim in the context of flavour physics two projects are proposed which have the common goal of improving the precision on theoretical predictions of relevant flavour observables and share the difficulty of being dominated by hadronic effects that require nonperturbative lattice calculationsin the first project i will study the leading electromagnetic and strong isospin breaking corrections to kaon semileptonic decays providing a method to extract the relevant decay amplitudes from finitevolume fv euclidean correlation functions evaluated on the lattice and computing analytically their fv dependence this aims to determine the ckm matrix element vus with subpercent precision and hence to test the ckm matrix unitarity predicted by the sm the goal of the second project is instead to obtain a first nonperturbative estimate of longdistance contributions to the mixing of neutral d mesons which are dominant but poorly known thus representing a limiting factor in the study of cp violation and np effects in this process this will be done by applying advanced reconstruction techniques to fv lattice spectral functionsthis proposal will have a relevant impact on flavour physics and phenomenology delivering new conceptual and algorithmic methods which will provide the foundations for future scientific progress
mapping literary representations of coercive confinement in ireland from the midnineteenth century to the present

the main research objective of confined is to define the ways in which literary representations of coercive confinement contribute to irish national memory the project focuses on irish literary representations of coercive confinement from the midnineteenth century to the present under the supervision of prof emilie pine its outputs will include a peerreviewed article in a leading interdisciplinary journal a digital exhibition on coercive confinement a podcast on confinement as well as a monograph proposal submitted to a leading university press by the end of the fellowship these outputs will be enriched by access to unique archival holdings in ucd library the national library of ireland and rt archives i will develop researchspecific skills learned via trainingthroughresearch in collaboration with experts at ucd transferable skills developed through handson training courses at ucd and intersectoral skills gained through prestigious collaborations with raidi teilifs ireann rt and the museum of literature ireland moli while undertaking a short visit at moli i will host an online conference on writing coercive confinement as well as a workshop with key stakeholders and policymakers i will apply for a cost action network on writing coercive confinement strengthening and expanding my networks as well as building towards an erc starting grant application in the immediate aftermath of the fellowship
mapping intersectionality a conceptual and methodological model for the study of inequalities and discriminations

intersectionality is a concept that has gone viral in the past decade becoming the most prominent analytical framework for analysing inequality its main premises are that people differently positioned in relation to their gender ethnicity age social class sexual orientation etc experience inequality in different ways showing that the interconnection of specific social positions produces concrete forms of inequality and discrimination that are differently configured in different spaces despite the expansion of this concept there is a lack of theoretical or methodological proposals that characterize how this variability is configured leading to a prevailing use of intersectionality as a vague conceptintermaps aims to make a significant paradigm shift in intersectionality studies by proposing a new theoretical and methodological model that while maintaining the original purposes and motivations of the concept develops a specific framework that can establish a systematization and characterization of intersectional dynamics it includes a new theoretical model for conceptualizing intersectional inequalities from a spatial and emotional perspective the development of new specific methods that combine and integrate qualitative quantitative digital and spatial gis approaches and an empirical application that will follow an intercategorical approach this will allow an analysis of intersectional dynamics in themselves the creation of new indicators of intersectional inequality and discrimination and the establishment of a characterization and mapping of intersectionality intermaps will enable a better understanding of how structural inequalities are reproduced and how they differently affect peoples everyday lives building bridges between feminist and postcolonial theories critical geographies and social psychology and overcoming the divide between quantitative and qualitative approaches in the social sciences
rethinking work beyond productivism from labour law and its uses

despite the diagnosis that rethinking work beyond productivism is key for ecological transition research on the future of work is confined to a general and abstract level and therefore remains inoperative this erc aims to elucidate the role that national systems of labour law which define and organise work already play and could play further in the emancipation of work from productivism to think about the future of work we propose to start from present institutions and uses of labour law but which at the margins of the system do already deviate from the dominant paradigm of productivism to then develop by extrapolation concrete and plausible trajectories and policy proposals for the future of work first we will conduct a largescale european comparative survey to map deviant institutions of labour law that support the development of nonproductivist timespaces ie places and moments dedicated to activities that are not productive in the economic sense of the term because they have little or no economic value second we will investigate through indepth case studies whether individuals develop deviant uses of labour law to secure to themselves nonproductivist timespaces beyond the law finally building on these results we will elaborate idealtype trajectories for emancipating work from productivism and develop legal arguments supporting the extension of nonproductivist timespaces supported by labour law based on international european and comparative law as well as empirical data collected throughout the project this erc has the potential to remedy the current scientific bottlenecks in articulating concrete and grounded policy proposals and trajectories for the future of work from a societal perspective it will inform socioeconomic players and political decisionmakers so that beyond their growing awareness of the limits of productivism on a finite planet concrete labour law reforms can be debated and decided upon
centre of excellence in artificial intelligence for digital humanities

the centre of excellence coe in artificial intelligence for digital humanities ai4dh era chair is an ambitious initiative in slovenia designed to enhance this european regions capacity to integrate artificial intelligence ai into the research conducted at the university of ljubljana in digital humanities dh this project seeks to establish the university as a leading institution in europe for ai applications in dh through the creation of a coe that combines toplevel ai research with direct engagement and support for dh scholars the coe will foster research excellence and provide tailored training and services thereby increasing the humanities capacity to leverage the many exciting opportunities offered by ai the coe will attract projects and other funding ensuring its sustainability enhancing the universitys research infrastructure and reversing the regions brain drain by attracting researchers to slovenia the ai4dh centre will be created under the leadership of professor antoine doucet who is currently professor in computer science at la rochelle universit france prof doucet has an excellent track record both as a researcher and innovator with many accolades as a manager of research and interdisciplinary highereducation activities
radiationdetected nmr new dimension for magnetic resonance spectroscopy and imaging

nuclear magnetic resonance nmr is a powerful spectroscopic technique used in various fields including chemistry biology and medicine however conventional nmr has one big limitation namely very small sensitivity due to a low level of polarisation of nuclear spins and inefficient signal detection by an induction signal in pickup coils my erc starting grant has explored the use of radiationdetected nmr rdnmr in which very shortlived nuclei were used as novel nmr probes bringing up to a billionfold increase in nmr sensitivity such nuclei are produced at a radioactiveion beam facility and are polarised on the fly before being introduced into the sample in this proof of concept project i want to use the advantaged of rdnmr and explore the prospect of turning it into a more easily accessible analytic tool i aim to build a prototype of a modular insert for conventional nmr and mri spectrometers that will allow insitu polarisation of longerlived nuclei that can be acquired commercially the insert will include a sample rf coil for spin excitation betaparticle detectors connections to introduce the hyperpolarising agent and the radiolabelled molecule that will be polarised in situ the insert will be complemented by hardware and software needed for the data acquisition during the project we will also explore the most suitable exploitation path we will refine the end users and end market including a workshop at cern and will investigate the patentability of the results i will collaborate with researchers from university of mainz knowledge transfer specialists and companies active in nmr and mri
fostering queer feminist intersectional resistances against transnational antigender politics

antigender politics pose a grave threat to modern democratic formations because they challenge peoples everyday survival bodily integrity and selfdetermination antigender spans the political spectrum and manifests not only in illiberal and authoritarian regimes but also in democracies that are considered liberal and inclusive taking a transnational and intersectional approach resist analyses antigender formations in their complexity and contradictions and explores the effects of antigender politics on the everyday lives of those vulnerable to it and on democracies on the whole resist engages with heterogeneous manifestations of antigender across the eu europe and beyond through eight national case studies belarus france germany greece ireland poland spain switzerland and a transnational case study of people living in exile as a result of antigender persecution resist pursues a mixed methods approach to analyse the production and circulation of genderequality repressive strategies and discourses and their effects on lived experiences and resistances resist innovates methodologically to engender democracy by fostering collaboration between academia and civil society organisations csos especially amongst people who come to be targets of antigender including women and lesbian gay bisexual transgender and intersex lgbti persons if those social groups whose fundamental rights are most at risk of violation by antigender are empowered to resist then entire democratic societies benefit resist centres feminist agency and collaborative knowledge production in a the research contents and results b the methodological design and c the social impact by generating new responsive feminist theories and practical solutions at a time of increasing political disillusionment resist creates hopeful imaginative futures transformative theories and more inclusive worlds
artificial intelligence for flood resilient infrastructure

amidst the mounting challenges posed by climate change particularly escalating urban flooding events the institute for artificial intelligence rd of serbia ivi introduces the artifact project focusing on the synergy of artificial intelligence ai and engineering for urban flood resilience recognizing the limitations of existing physicsbased models the artifact seeks to harness ais capabilities to elevate urban flood prediction management and mitigation emphasising the importance of integrating naturebased solutions nbs and ai in urban planning to confront future flood risks notably ivi aims to utilize vast datasets and advanced machine learning techniques to offer indepth realtime analysis concerning climate change impacts by intertwining aidriven solutions and expertise of ivi with engineering prowess from leading eu partners delft university of technology tu delft ihe delft institute for water education ihe delft and hamburg university of technology tuhh the initiative aims to foster advanced strategies in aibased urban flood modelling as ivi positions itself at the forefront of aidriven environmental modelling the artifact project emerges as a beacon of innovation cementing ivis role as a regional leader and research lighthouse in this domain to achieve this artifact will use staff exchanges expert trainings summer schools and workshops to boost the research excellence innovation capacity and visibility of ivi members focusing on esrs and administrative staff the project will gradually shift focus from research to innovationdriven implementation by setting up bluegreen ai hub at ivi as an interface towards the regional ict sector bridging highquality ivi research with thriving regional ict innovation scene with the help of eu partners artifact will put the ivi on the european map of emerging aibased flood and nbs modelling while via bluegreen ai hub ivi will become integral part of regional ict industry
advancing research and training on ageing place and home

ageing in place is critical to the future of ageing societies in europe older peoples places are recognised as fundamental to longterm health and wellbeing outcomes a fact that has been magnified during the covid19 pandemic yet critically almost a third of older people in europe experience neighbourhood deprivation a fifth encounter a lack of cohesion a growing number are homeless and approximately 3 million people continue to reside in institutional settings there are significant concerns that efforts are failing to support ageing in place with its development as a field fragmented across disciplines and sectors and with few researchers equipped to tackle this fragmentation innovation in research and policy risks stagnation this is despite the renewed interest and urgency arising from the pandemic in deinstitutionalizing later life residential experiences homeage will institute an interdisciplinary intersectoral and international programme of doctoral training and research that drives the development of new leaders in excellence for the advancement of evidencebased innovation on ageing in place in tackling the three interconnected challenges of 1 needs and systems 2 home and belonging and 3 rights and voice homeage delivers a unique employability and skills development process for doctoral researchers drs ensuring that they can lead the response to current research and policy deficits homeage addresses significant demand for drs who possess essential competencies to overcome challenges concerning europes demographic transition and sticking points in its developing silver economy homeage directly addresses the critical priority of enabling older people to age in a place that is right for them within the whos global strategy and action plan on ageing crucially it also addresses strategic themes in the eu green paper on ageing and key goals within the un sustainable development agenda concerning equity and sustainability