Dragon09/odtu_chatbot huggingface dataset:
advanced epigenetics studies to increase the research and innovations capacity of the roumen tsanev institute of molecular biology of the bulgarian academy of sciences

the global objective of the roumen tsanev institute of molecular biology is to develop its traditionally strong focus on epigenetics and chromatin biology towards a worldclass level of research excellence our institute has identified prof stefan dimitrov a top level scientist and an internationally recognised expert in the field of epigenetics as a prospective era chair holder we intend to achieve significant improvements in research and innovations capabilities of the imbbas in the area of the institutes long term specialisation producing a clear impact on publication quality and newly acquired knowledge with translational potential this should be achieved by transfer of knowledge with a major focus on phd students and young postdocs to provide for sustainable growth of imbbas and reduce the brain drain
nurturing heritage science with novel bioarchaeological methods in the eastern baltics

paleomix proposes an interdisciplinary research programme to better understand cultural heritage as one of the main definers of european identity and grant its maximum informative value and longterm preservation paleomix bridges humanities and natural sciences by bringing together experts from the eastern baltic and western europe to implement topnotch bioarchaeological and computational research methodologies for conducting a more sustainable study of tangible heritage the twinning exercise consolidates the research and innovation capabilities of the internationally acknowledged research centres bioarch university of york uk and globe institute evo and eco genomics sections university of copenhagen dk and laboratory of human evolution isotopik lab university of burgos es to the coordinator university of tartu ee allowing the establishment of a dedicated researchinnovation ri hub on tangible heritage studies the transdisciplinary research excellence that becomes available through tight cooperation mobilities and creation of digital infrastructure paleomix oad in the e baltics is first demonstrated in the research pilot about the most important cultural change in human history neolithization with the push from the twinning partners the ri hub will become a selfsustainable naval point and a pool of knowledge to disseminate the best practices in heritage studies to regional researchers and other stakeholderson a wider scale paleomix promotes the integration of humanities and natural sciences to tackle prominent questions about european common heritage paleomix further i contributes to the sustainability of the knowledgebased society with its extensive knowledge production and dissemination among the general public ii strengthens the links between academia business and other governmental organisations through novel services offered by the ri hub and iii acts as a springboard for the next generation researchers in heritage studies
nano and colloidal plastics in soil input plant uptake and risk assessment

plastic pollution has been identified as a key to soil health yet information on inputs and concentrations in agricultural soil is limited to microplastics 1 m5 mm or larger particles but nothing is known about submicron plastics including colloidal plastics cps 11000 nm and nanoplastics nps 1100 nm due to a lack of analytical methods this is critical because mainly submicron plastics harm soil biota are taken up by plants and thus pose a risk to human health via the food chain as plastic pollution is rising we urgently need to quantify submicron plastics in agricultural soils and the resulting plant uptake and contamination of our food to safeguard our food production hence the nanosoil project is designed to test the following hypotheses i submicron plastics can be routinely detected using field flow fractionation fff with adaptions from environmental colloid tracing ii agricultural practices compost and sludge application wastewater irrigation plastic mulching are main pathways for submicron plastics into soil as well as iii the use of socalled biodegradable foils in agriculture i further hypothesize that iv uptake and accumulation of cps and nps in crops are polymer and plantspecific temperature and humiditydependent with mainly nps reaching edible parts to quantify submicron plastics i will i optimize a recently developed method using fff and pyrolysis gas chromatography this method will then iiiii be used on soil samples from agricultural fields with known plastic input pathways for conventional and biodegradable plastics including an europewide survey and existing controlled field trials finally iv plant uptake will be assessed for representative crops with my combined expertise in nanoparticle and plastic analysis in soil nanosoil will for the first time generate data that will form the basis for all future environmental fate and ecotoxicology studies of plastics and a robust risk assessment
the early metabolic stages in the evolution of antimicrobial resistance

antimicrobial resistance amr is a rising global health threat and rapid evolution of resistance against existing or newly developed antibacterial compounds is predicted to lead to 10 million deaths and 60 trillion of lost economic output by 2050 while resistanceconferring mutations their inheritance and spread by horizontal gene transfer are increasingly wellstudied our understanding of preresistant cells survival and resilience in the presence of lethal antibacterial doses remains unclear this proposal is stimulated by recent findings suggesting that the extracellular metabolic environment and metabolic adaptations play an overlooked role in transiently buffering antibiotic lethality and therefore increase the emergence of subpopulations of cells and their effective size that supports the evolution of antimicrobial resistance in this proposal i will systematically dissect mechanisms at work in subpopulations of preresistant cells of priority pathogens pseudomonas aeruginosa and acinetobacter baumannii that can transiently cope with antimicrobial treatment i propose to combine my expertise in bacterial physiology with the ralser labs ultrafast massivescale proteomics and phenomics technologies i will systematically investigate the metabolic stress response in clinically relevant conditions and identify the key metabolic and signalling processes that support the survival of subsets of challenged cells upon exposure to major classes of clinically applied antimicrobials finally adaptive evolution experiments combined with crisprcas9 gene editing will validate causal effectors of identified tolerance mechanisms that precede the appearance of resistanceconveying adaptations here i will acquire technical skills in innovative technologies and the host lab will benefit from my experience in working with pathogenic bacteria i will lead public engagement efforts and disseminate scientific research outputs on an important global health issue
validation of magnetfree wireless charging and communication for intrabody devices

cochlear implants cis which electrically stimulate the auditory nerve to repair hearing in people with severetoprofound hearing loss are used for more than 40 years however conventional cis have major drawbacks one of which is the use of magnet in the implanted unit of the ci to help perfect alignment of the coils that are used for rf link between external and implanted units however using magnets prevents the ci users from accessing some of the medical treatment and examination methods like mri and may lead to damage on the skin to eliminate the drawbacks of conventional cis including the magnet utilization we introduced flamenco concept which has demonstrated that a fully implantable cochlear implant fici mimicking the natural hearing mechanism of the ear is feasible in the erc flamenco project we developed the fici as a magnetfree device which necessitated development of a novel wireless power and data transfer wpdt application to minimize transfer losses thus the duration for utilization of external wireless unit to charge the implanted rechargeable battery by introducing a unique multimode rectifier circuit charging the load for an extended coupling range and eliminating the requirement of alignment magnets the efficiency loss is reduced and the charging efficiency is maximized in the aria project which stems from the developments within the erc flamenco project we will perform technological and commercial validation of wpdt unit according to the market standards then optimize the unit for fabricating a demonstrator to be integrated to the fici we will also look into the potential for integration with other active implantable medical devices aimds if implemented successfully the aria wpdt not only would be a major step for commercialization of our fici which has already triggered interest of ci makers users and investors but also could lead to new applications of aimds
the bilingual semantic system sense computational assessment of crosslinguistic meaning representation across cultures

growing evidence suggests lexical semantics is not universal being shaped by culture and translation equivalents may bear distinct meanings in each language if so how do bilingual brains juggle competing meaning representations for translations sense will investigate the impact knowing a second language has on the native languages semantic system across cultures to do so we will use two recent computational approaches distributional semantic and word association models obtained from linguistic corpora and free association data respectively both methods have shown promising results in predicting human performance in semantic tasks making them ideal candidates to inform psychological theories yet which models better reflect human semantic representation is under debate further few studies in semantic memory research have used these tools while researchers have stressed the need to adopt these methodologies these calls almost invariably have a monolingual scope neglecting the pressing questions bilingualism poses on the nature of the semantic system sense has three overarching goals 1 to assess the role of culture in the construction of meaning by examining the conceptual structure of languages from different primary families spoken in culturally distinct societies spanish turkish chinese english the invariable second language will also be studied 2 to measure bilingualisms impact on semantic representation by investigating how l2 english semantic information integrates into the already established native languages semantic systems 3 to test which models are better suited to account for meaning representation by comparing their predictability of human performance in a battery of semantic tasks overall sense will make a solid contribution to understanding how culture and bilingualism shape the semantic system while helping to establish modern computational techniques in cognitive psychology research
automated turnkey insect rearing farm enabling farmers to produce their own sustainable insect protein feed

farminsect responds to the global need for alternative protein sources for animal feed in a sustainable and efficient way for farmersfarminsect is the first insect company to put existing farmer in the center of the solution utilizing bsf larvae in a full closed loop system farmers feed the larvae on organic sidestreams just as natures perfect upcycling machines larvae convert organic residues to create highquality protein to feed animalswith farminsect a livestock farmer can produce up to 1000tnyr of bsf larvae at 800 vs 1350t of fishmeal towards replacing dependency on global markets key to farmers is the healthy value of larvae feed for animals the bsf larvae contain natural immuneboosting peptides that improve the immune system of farm animals insects as feed reduce abnormal behavior such as feather picking in chickens or tail biting in pigsfurthermore added value organic fertilizer is produced as byproduct
cohesion in particulate media

how grains flow can we predict the behavior of sand snow powders and more generally of a collection of particles in many situations both in nature or industry this question is of importance to predict avalanches landslides or designing silos and industrial processes while for simple fluids the measure of the viscosity is sufficient to compute and predict the flow for granular materials the question remains open the challenge of understanding the physics of granular flows has motivated many researches and constitutive laws have been developed for grains interacting by friction and collision however in many applications grains present cohesion and predicting their behavior is much more challenging sticky or humid grains powders snow fibers are examples of granular media having difficulties to flow with clogging agglomeration intermittency the cohpa project aims at a fundamental understanding of the behavior of cohesive granular materials by combining experimental numerical and theoretical approaches with the ultimate goal of developping constitutive laws able to predict their behavior in any configuration the two work packages correspond to two types of cohesive materials in wp1 i will study cohesion resulting from the presence of adhesive forces between particles and i will focus on the development of model materials made of sticky grains with tailored surface properties as well as on real powders by developing innovative rheological technics coupled with numerical simulations we hope to get a new understanding of the rheology in wp2 i will study the cohesion arising from entanglement between frictional particles as observed in an assembly of fibers as in a bird nest or a cotton ball or when mixing fibers and grains typically roots in soils they constitute a new class of disordered materials in which the tensile strength results from a subtle coupling between geometry elasticity and friction which is not yet understood
scilifelab programme for future leaders in life science

scilifelab pulse is a mscacofund postdoctoral programme of excellence in life sciences coordinated by the swedish research infrastructure scilifelab pulse will recruit 48 postdocs in academic and entrepreneurial tracks that will receive 3 years of international interdisciplinary and intersectoral career training focused on preparing them as impactful leaders in academia andor industry pulse postdocs will be immersed in the internationally recognised scientific community of universities 10 research institutes 4 infrastructures 3 companies 12 and associations 4 providing joint core career and specialised training and access to cuttingedge hightechnology infrastructures that comprise the foundation of scilifelab at the heart of pulse is a wellconceived core training programme augmented by secondments to ensure necessary breadth and tailored individualised training adapted and relevant to academia and industry and to facilitate international scientific exchange the pulse output will be a new breed of scientists wellprepared in the application of highthroughput technologies and datadense analytical approaches and who can confidently meet the emerging societal challenges confronting the european research area specifically in precision medicine pandemic laboratory preparedness planetary biology and drug discovery and development pulse is aligned with the european charter for researchers and the code of conduct for the recruitment of researchers and takes into account the msca supervision guidelines and green charter pulse will have an impact that extends beyond its duration establishing dialogues with multiple stakeholders in the nonacademic sector and by setting new standards in postgraduate research training in life sciences internationally pulse will be administered by the swedish royal institute of technology kth and has an overall budget of 190 meur of which 36 stems from the ec and 64 from participating institutions
black hole stability

the discovery of black holes first as explicit solutions of einstein equations of general relativity and later as possible explanations of astrophysical phenomena has revolutionized our understanding of the universe from a mathematical perspective a central issue is to investigate the stability of these fascinating objects this is the focus of the present proposal containing the following work packageskerr stability conjecture this concerns the nonlinear stability of kerr black holes which form a 2parameter family of explicit solutions to einstein vacuum equations it has become since its discovery by r kerr in 1963 a central topic in general relativity first during the golden age of black hole physics and in the last twenty years in mathematical relativity these efforts have led to the recent resolution by the pi and collaborators of the conjecture in the slowly rotating case the goal of this work package is to tackle the general caseblack hole stability with matter breakthrough concerning the stability of kerr for einstein vacuum equations opens the door to other physically relevant cases in the context of einstein equations coupled to matter this work package aims at proving the stability of charged kerrnewman black holes for einsteinmaxwell equations kerr back holes for massless einsteinvlasov equation as well as the stability of kerrde sitter black holes in the case of an arbitrarily small cosmological constantprices law and kerr stability an open problem concerns the optimal decay rate for perturbations of kerr that can be achieved in the kerr stability problem the analogous problem for corresponding linear toy models is known as prices law obtaining an optimal decay rate in the context of the kerr stability problem would not only vastly extend prices law but it is also expected to have important implications on the strong cosmic censorship conjecture concerning the deterministic character of einstein equations
federated virtual twins for privacypreserving personalised outcome prediction of type 2 diabetes treatment

virtual twins may be used as prognostic tools in precision medicine for personalised disease management however their training is a data hungry endeavour requiring big data to be integrated across diverse sources which in turn is hampered by privacy legislation such as the general data protection regulation privacyenhancing computational techniques like federated learning have recently emerged and hold the promise of enabling the effective use of big data while safeguarding sensitive patient information in daibetes we build on this technology to develop a federated health data platform for clinical application of the first internationally trained federated virtual twin models our primary medical objective is personalised prediction of treatment outcomes in type 2 diabetes which afflicts 1 in 10 adults worldwide and causes annual expenditures of ca 893 billion eur while healthcare providers are becoming increasingly effective at targeting diabetes risk factors eg diet or exercises no guidelines as to the expected outcome for a given treatment for a specific patient exist to address this urgent yet unmet need the federated daibetes technology will harmonise existing data of ca 800000 type 2 diabetes patients of 4 cohorts distributed across the globe and learn prognostic virtual twin models those will be validated for their clinical relevance and applied in clinical practice through a dedicated software we aim to demonstrate that our personalised predictions have a prediction error that is at least 10 lower than that of population averagebased models this federated virtual twin technology will enable personalised disease management and act as a blueprint for other complex diseases our consortium combines expertise in artificial intelligence software development privacy protection cyber security and diabetes and its treatment ultimately we aim to resolve the antagonism of privacy and big data in crossnational diabetes research
intelligent multi agent robotic systems

the imars vision aims to revolutionize emergency services by harnessing ai robotics iot and crossdisciplinary expertise this research program facilitates collaboration among three first responders an industrial sme and four research institutions fostering the exchange of knowledge and personnel across sectors and borders its core impact lies in promoting a holistic problemsolving approach and practical innovation in emergency response through1 multidisciplinary collaboration leveraging diverse fields to create solutions surpassing the limitations of individual disciplines2 knowledge exchange and mobility offering secondments to blend academic and industrial insights ensuring realworld applicability of research3 professional development providing training to develop a skilled workforce ready to deploy advanced technologies in emergencies4 creativity and entrepreneurship cultivating an environment where innovation flourishes potentially sparking new ventures focused on emergency services5 sector interaction ensuring direct involvement of endusers from first responders to industry experts guarantees that developments are usercentric and actionable6 technological advancements imars addresses the full technology spectrum from data acquisition to advanced communication aiming for comprehensive enhancements in emergency operations7 humanitarian focus prioritizing the use of robotics in search and rescue to improve outcomes for society reflects the projects commitment to humanitarian values imars stands to redefine emergency service provision making it more robust and efficient by aligning cuttingedge technology with strategic collaboration imars sets the stage for global advancements in emergency management and could become a benchmark for international cooperative innovation
developing new antibiotic peptides targeting eskape bacterial trans translation

antimicrobial resistance amr poses a major threat to human health around the world the amr crisis has emerged as one of the leading public health threats of the 21st century this global crisis is due to the fact that bacteria share and increasingly develop new resistance mechanisms as a consequence of the misuse of antibiotics as well as a lack of new drug development to combat this crisis we need new classes of antibiotics and most importantly against new targets it is therefore crucial to identify new molecular processes that can be targeted ideally these should be i conserved among all pathogenic eskape bacteria ii indispensable to bacterial survival or at least its fitness iii sufficiently variable that different species can be distinguished from each other iv absent in eukaryotes v not targeted by current antibiotics vi unrelated to existing amr mechanisms and finally vii reproducible in non hazardous in vitro experiments in this quest transtranslation appears to be a perfect candidate development of new antibiotics that target transtranslation from multidrug resistant eskape pathogens will be addressed in this project transpeptid we will use engineer antimicrobial peptides based on the c terminal tails of smpb proteins from espake pathogens with the propose to compete with endogenous smpb and in turn to inhibit transtranslation the project is organized in three main objectives that will constitute three major breakthroughs in the field ob1 optimization and characterization of designed peptides in eskape pathogens ob2 biophysical analysis of selected peptides in target eskape pathogens and ob3 determination of the high resolution structures of the complexes between the peptides and their molecular targets by cryoem since transpeptid is a multidisciplinay project that embraces both fundamental and applied science it will contribute significantly to strength the research and training profile of the researcher