Dragon09/odtu_chatbot huggingface dataset:
photodynamic ocular drug delivery system with optical coherence tomography oriented microscale robots

retinal diseases are the most common reasons of the irreversible blindness worldwide common retinal diseases such as diabetic retinopathy macular degeneration retinal vein occlusion and noninfectious uveitis mostly require intravitreal steroid injections in clinical management unfortunately the intravitreal steroid injections leads other important ocular problems such as elevation of intraocular pressure intravitreal infections and progression of cataracts because of these reasons targeted drug delivery systems are necessity for the medical treatment of retinal diseases photodynamic ocular drug delivery system with optical coherence tomography oriented microscale robots photodoctor project combines three novel technologies to solve this important clinical problem the first technological advancement for the project is dexamethasone saturated hyaluronic acid ha hydrogels with organoruthenium complexes which enables controllable degradation under visible light exposure with the help of visible light controlled degradation dexamethasone will be released with the light pulses then the hydrogels will be supplemented with super paramagnetic iron oxide nanoparticles spions and 3d printed as helical microswimmers insertion of the spions will help the magnetic actuation of the hydrogelbased microrobots in the intraocular space lastly spions supplemented ha hydrogels will be observed with high resolution optical coherence tomography oct system in the intraocular space to guide them in diseased area of the retina while ha based structure increases penetration in vitreous and helps to the attachment on the retina spions will increase the visibility of the microrobots in oct imaging by this way magnetic driven visible light triggered intraocular drug release system with the oct guidance will be produced and it could be used for not only intravitreal steroid delivery but also treatment of retinal tumors and other retinal problems
predicting functional diversity of invasive freshwater plants

biodiversity is facing the imperative challenge posed by invasive species responsible for substantial damage to habitat integrity and ecosystem services freshwaters are particularly susceptible to invasions and this is causing a dramatic decline of the irreplaceable services they provide this project aims at untangling the mechanisms underlying invasion performance by determining and predicting the spatial range of functional variation of three highly invasive freshwater plants elodea nuttallii pistia stratiotes and trapa natans in response to environmental conditions thereby obtaining better estimates of their influence on the functioning of invaded habitats this global msca is outlined in 36 months and includes 24 months at mcgill university canada under the supervision of prof l iversen an outstanding scientific leader in the field of landscape geography and freshwater science and 12 months at the university of parma italy with supervisor dr r bolpagni a renowned expert on freshwater plants i will measure leaf functional traits of target species across ecological gradients and describe strong traitenvironment relationships in europe and qubec i will also perform manipulative experiments to validate and implement spatial models of trait variation training through research will be combined with courses on spatial modelling science communication and project management dive in provides a robust framework that can be applied to different invasive plants and global change scenarios supporting the development of effective actions to counter invasive freshwater plants establishmentsuccess dive ins impact will be maximized by publishing papers in highquality scientific journals as well as by public engagement activities including a blog workshops and citizen science initiatives this project is a key step in my future career and will grant me a unique training opportunity opening doors to prestigious research positions in europe
quorum sensing as a tool to detect and target prooncogenic microbial biofilms associated with rightsided colorectal cancer

colorectal cancer crc development and progression have been linked to the presence of prooncogenic bacterial strains in the intestine such as fusobacterium nucleatum pks escherichia coli and enterotoxigenic bacteroides fragilis these pathogenic bacteria produce toxins that can disrupt gut epithelial integrity resulting in heightened proinflammatory response enhanced dna mutations and increased cell proliferation which can eventually lead to adenoma formation in addition these bacterial pathogens show increased genotoxicity by forming invasive polymicrobial biofilms thereby resulting in crc development recently it has been reported that anatomical location plays a crucial role in crc development progression microbial colonization response to therapies and disease outcome indeed rightsided crc is generally associated with prooncogenic bacterial biofilms and is known to have an overall worse prognosis compared to leftsided crc pathogenic bacteria use quorum sensing qs machinery in the gut for their communication which is essential for biofilm formation we aim to develop an intervention strategy employing qs machinery to engineer a probiotic bacterial strain with sensing and killing properties to detect and target these prooncogenic polymicrobial biofilms the sensor device will detect autoinducers produced by pathogenic bacteria on encountering their biofilms activating the killing device the killing device expresses a biofilm degrading enzyme dispersin b which will disrupt these biofilms and eventually kill the pathogenic bacteria residing in these biofilms by the type vi secretion system these polymicrobial biofilms can act as a marker of crc and help to understand the role of crcassociated pathogenic bacteria in crc development which can eventually serve as a basis for developing future strategies for the diagnosis and treatment of crc and other intestinal disorders associated with biofilms formed by pathogenic bacteria
federated cyberphysical infrastructure for odd continuity

the operational context is the cornerstone to ensure performance and safety of ccam the odd by design defines the operating environment for which a system is designed for on the other hand authorities and road operators are responsible for operating the pdi with a variety of vehicles and systems with limited knowledge on the diverse odd specifications to answer the question of how safe is a ccam service one should not only address the odd used for shaping the functional boundaries of ccam top down but also the infrastructure system related safe and secure communications related and conditions traffic weather hazards related aspects of the road environment these systems will operate bottom up the grande challenge is to design broader odds that allow for cooperation with the pdi in a safe system design framework the industry cannot unilaterally develop and operate sustainable and robust odds without the feedback from authorities and operators future odds should be designed with many redundancies fail safe design to allow for increased tolerance to vehicle and contextspecific capabilities and human errors and cooperate with physical and digital road infrastructure to boost proactive safety seamless safe and secure physical and digital environments must coexist and collaborate to allow for the appropriate levels of data information and decisions flow froddos vision is a future of robust safe secure and seamless connectivity and automation that can adapt to physical technological and social challenges and support user centric mobility and development froddos overarching aim is to develop and test a complete suite of methods and tools based on the principles of safe systems design in a federated dt environment leveraging advanced sensing ml hybrid ai and simulation to account for increasing adaptability and sustainability of odds to complex and dynamically changing road contexts and allow for improved management of ccamenabled pdi
nams within integrated safety efficacy evaluation of chemicals and pharmaceuticals

the vision of the namwise project is to provide a supporting framework to pave a scientifically substantiated way towards a paradigmshift in ecotoxicology that will not rely on in vivo data to fulfil its vision the project will leverage the acquired knowledge on new approach methodologies nams and then gather new input from all stakeholders to refine improve and optimize their use in regulatory contexts for chemicals and pharmaceuticals the project will merge under its umbrella inputs from a multidisciplinary consortium comprising academia namdevelopers nam users cros regulators while reaching out towards societal expectations the workplan of namwise is organized along farreaching objectives driven by the interest for all the stakeholders1 sustain and amplify the momentum built by similar initiatives by combining expertise on in silico tools in vitro assays and a widespread network with external projects2 provide a pragmatic approach based on casestudies for hazardrisk assessment and drug efficacy that will guide the project in implementing nams strategies these procedures will be submitted to a peerreview to ensure that what the nam community receive is of a high standard 3 deliver an analysis of requirements in terms of standardization and validation of nams that benefits from the input of the pepper platform on prevalidation a unique french initiative on nams based on public and private funding4 foster fruitful interactions between stakeholders catalyzed by several actions including a series of workshops and training initiatives targeted on the needs of cros identified during the project 5 propose a way forward for solving nams shortcomings and enhancing their driversfinally the project will provide a white paper during its final open symposium that will render namwise a major reference point and essential force for bringing forward proposals for animalfree chemical and drug assessments
hydrogen high pressure supply chain for innovative and cost efficient distribution

hygher hygher aims to improve gaseous hydrogen delivery infrastructure for hydrogen mobility developing innovative solutions and integrating them optimally along the supply chain steps these include an innovative filling center able to compress and fill over 2tday of h2 from green electrolysis two new high pressure trailers featuring novel cascading concepts for optimized fillingunloading each able to transport 125 tons of h2 at 500 bar and hrs adaptations for full valorization of high pressure h2 increasing economic and technical advantages the 14month demonstration will take place in the region of paris to supply the hype fleet of hundreds of fcev taxis with locally produced h2 via a network of hrs reinforcing eu h2 infrastructure along tent corridors a strong reduction in capex opex and footprint will be demonstrated thus reducing the price of hydrogen at the nozzle the project will pave the way for replication of the solution via standardization efforts including a generic design of component interfaces as well as recommendations on regulations and standards to simplify future implementations safety will play a central role through the involvement of h2 safety experts circularity aspects will be studied and applied to progress toward a sustainable supply chain throughout the project a future upscale of the solution to higher pressures and capacities will be prepared and all requirements regarding design safety economic and regulatory aspects identified related requirements and challenges will be discussed with an advisory committee and with a wide panel of stakeholders this will strengthen collaboration raise awareness about potentials and benefits of the high pressure hygher solution and accelerate replication and scaleup to foster market uptake 6 replications will be initiated in the scope of the project hygher will accelerate the development of 3 smes thus contributing to consolidation of eu leadership in h2 technologies
trajectories of taste an analytical framework of culinary change after migration

how and why do cuisines change after migration the taste project offers a novel approach to study the global spread of cooking techniques products dishes recipes food practices and taste hierarchies by focusing on three relatively old indonesian diasporas of suriname sri lanka and south africa its researchers address the following hypotheses 1 what people choose to eat is primarily driven by embodied notions of taste2 food preferences are inherited and exchanged3 culinary change significantly resembles linguistic changeculinary change is yet to be analyzed comprehensively while we know from earlier studies that flavor affects food preferences and that migration affects eating patterns we lack an analytical language and integrated methodology to examine these phenomena systematically drawing from the conceptual apparatus of historical linguistics and stateoftheart fieldwork practices this project develops a new methodological toolkit to identify with greater precision than before how cuisines evolve after migration how different culinary traditions influence each other and which different mechanisms propel these processes the team will collect and analyze recipes and food descriptions from three countries housing indonesian diasporas complemented by followingthethings approaches narrative research gastrolinguistic analysis and sensory elicitationthe projects three work packages focus on the role of contactinduced borrowing of culinary features phd1 inherited notions of taste phd2 and economic dimensions of food preferences phd3 these subprojects use the same theoretical and methodological framework but focus on different categories sweet desserts food served during feasts and poverty food respectively the resulting insights on culinary change hold a largely unacknowledged key to promoting more sustainable consumption patterns and mitigating the fastincreasing number of foodrelated problems worldwtbd
maglevderived systems for rail

the made4rail project aims to explore nontraditional and emerging maglevderived systems mds and to evaluate the technical feasibility and effectiveness to introduce mds in europe under safety aspects and technicaleconomic performance identification and benchmarking of the different maglevderived technologies for transportation systems and their state of development definition of a common architecture and specification of the subsystems and technologies needed for its commercialization are expected in the made4rail project moreover a risk analysis and identification of needs for standardization on safety and security in operations of mds will be performed also the assessment of the technical and economic feasibility to introduce these systems into the common european mobility network will be implemented as well as the development of a european roadmap for the possible future implementation of mds lastly the design of the concept for an mds vehicle subsystem and a prototype of a sample vehicle for a european use case are foreseen in this projectthe made4rail project is expected to have significant impacts such as contributing to the development of mds promoting more sustainable passenger and freight transport and initiating a path towards the reinforcement of railway as the backbone of a multimodal sustainable and efficient mobility network by possibly upgrading the existing railway linesfacilities through the adoption of a maglevderived technology moreover the project fosters information exchange and growth and diffusion of knowledgemade4rail brings together a multidisciplinary group of experts from diverse backgrounds with a wide range of competences and expertise that would contribute to the success of the project such as infrastructure managers transport authorities engineering and consultancy companies technological developers and research centers and universities
disruptive electrical propulsion power processing unit

the objective of deepppu project is to develop and introduce to the market a disruptive power processing unit ppu for electrical propulsion gridded ion thrusters this solution will stand out with its outstanding 40 mass and 35 volume reduction compared to the existing solutions on the market while reducing the cost of the unit by a factor of two the deep ppu project will strengthen the eus space sector competitiveness in the international market while securing the autonomy of supply for critical technologies and equipmentthe target ppu will be achieved through the use groundbreaking technologies in space namely gallium nitride semiconductors and commercial offtheshelf components together with the implementation of custom design of power magnetics the integration of the radio frequency generation module and the synergies with previous developments in the frame of giesepp gridded ion engine standardised electric propulsion platforms a multidisciplinary team of entities across europe has been set providing the right background and expertise to perform the required activitiesthe proposed ppu product fits the horizoncl42022space0112 topic technologies and generic building blocks for electrical propulsion specifically addressing the second area of this topic ri on electrical power architecture and related components power processing unit direct drive etc
john hume and the creation of the european dimension in ireland

john hume and the creation of the european dimension in ireland will investigate how john hume helped to create the conditions for a diverse constituency in northern ireland to reimagine its political and cultural identity in europe the kernel of jhcedi is a research question that has not been adequately addressed in the literature on hume or on ireland in europe how did humes reconceptualisation of ireland in europe facilitate the peace process in northern ireland this project could hardly be more timely a thorough public awareness of the history of northern ireland in europe through the lens of its key political actor hume over the past halfcentury could provide a vital contribution to public discourse and attitudes towards the future today three pillars of considerable geopolitical significance the threat to the good friday agreement the disruptions of brexit and the ongoing controversies that surround the northern ireland protocol give urgency to jhcedi no work yet exists that fully transcends the paradigms in which hume has been framed by situating humes project in the paradigm of nation formation in a european tradition as well as in ethnic studies this is the gap in the literature that jhcedi will address the vision he shared with t of a europe of regions and of shared sovereignty was at once a transnational priority for hume and a strategy to resolve irelands internal dilemmas the objective of jhcedi is to investigate how hume helped to create the conditions for a diverse constituency in northern ireland to reimagine their political inheritance the outputs of jhcedi will be the articles and the public dissemination of my findings being essential actions to lay the groundwork for my monograph in this subject
a deep learningderived shear wave elastography biomarker for cancer therapy prediction

the efficacy of standard cancer therapies varies and while some patients respond to a particular treatment other patients do not gain any benefit in response an era of individualized cancer treatments is emerging which are based on the identification of biomarkers that characterize the state of a tumor many solid tumors eg breast cancers and sarcomas stiffen as they grow within a normal tissue tumor stiffening is a known factor leading to compromised efficacy of therapeutics repurposing drugs in order to alleviate tumor stiffness before the initiation of therapy has been tested in preclinical studies and has recently made it to the clinic despite recent success of these strategies optimization of their application is understudied here we aim to harness the power of deep learning dl methods in order to construct a robust biomarker based on ultrasound shear wave elastography swe the biomarker will aim to i predict the tumors response to treatment with chemo and immunotherapy and ii monitor treatment outcomes in the case of strategies that target tumor stiffness the project will capitalize on the existing strengths of the applicant in medical image processing and dl and the expertise of the host in tumor mechanopathology and in vivo experiments in past experiments the host acquired a large number of swe tumor data which will enable the development of the dl biomarker through the experimental part of the project additional data on murine cancer models will be acquired enabling the validation of the biomarker formulation of the developed dlderived biomarker in a userfriendly software will allow for potential clinical translation and further exploitation through ipr the applicant will acquire new knowledge in the fields of cancer therapy tumor biology and in vivo experimental design the attained knowledge and skills will be instrumental to the applicants ambition to lead the field of artificial intelligence in biomedicine
interconnecting innovation ecosystems for common european data space in health

the aim of the project is to foster the dialogue and development towards more inclusive dynamic gender diverse and interconnected innovation ecosystems in europe to reach the european common data space in health the joint action plan to be developed in the context of the project is oriented at overcoming the current deployment gap of digital health in europe and to unlock the power of health data for innovative medicine and healthcare of the future enabling new scientific discoveries innovative commercial health products and services all in all resulting in more efficient prevention and treatment of illnesses and ensuring a better quality of life in europe and globallythe consortium includes four clustersnetworks all representing broad innovation ecosystems that have for many years been working to advance the secondary use of health data and creation of the common european health data space this includes biocat bioregion of catalonia biocat coordinating country spain council of european bioregions cebr based in belgium health cluster portugal hcp portugal and scanbalt network sb estonia the consortium takes leadership in coordinating the project activities but a wide range of clusters bioregions and wider ecosystem stakeholders will be engaged in the project based on the joint effort of the core partners