Dragon09/odtu_chatbot huggingface dataset:
network of networks 4 democracy

nets4dem puts forward a network of networks approach to establish and develop a european network of practitioners and researchers in the field of democracy civic deliberation participation and citizenship educationthe consortium brings together widely networked organisations with longterm expertise in democratic innovation across a broad range of areas including digital democracy rule of law climate change also through cultural and creative approach it is composed of umbrella organisations that will draw on their already existing networks to contribute to the call outcomesthe unique approach that nets4dem puts forward is to weave more and better connections between existing actors and networks already active in the wider democracy field taking advantage of each others strengths and reducing duplicationnets4dem will focus its efforts on four main objectives 1 creating fostering and sustaining stronger network of policy makers practitioners and researchers 2 systematizing and connecting the fragmented knowledge on democratic innovation and governance research 3 establishing a coordinated european approach to promote systematic accessibility of democratic innovation 4 raising the ambition of policy making through policy recommendations to strengthen democracy at all levels of governancewe will seek to address the challenges weve identified the need for better collaboration and networking in the democratic field the need to connect existing knowledge on democracy and governance and make it more accessible so that policymakers and practitioners are better equipped to the address complex challenges they are facing for inclusive societies and more resilient democracyto address these and potential new challenges substantial efforts are required from researchers practitioners policy makers and citizens one of the most impactful ways to support this work is by connecting the efforts of all those who are pursuing the same goal
identification of bat antiviral innate immune effectors

numerous recent disease outbreaks have been linked to zoonotic viruses originating from bats including marburg nipah and the severe acute respiratory viruses like sarscov2 countless virushost encounters during bat evolution have shaped chiropteran immunity to balance defense and tolerance to viral infections ultimately participating in bats current interplay with viruses and capacity as a viral reservoirone of the first barriers against invading pathogens is the innate immunity which notably includes antiviral factors that directly or indirectly inhibit the replication of invading viruses in the host cell recent research on bats showed the functional diversification of several antiviral effectors underscoring their pivotal role in bat immunity however because only a handful have been studied my goal is to identify key and novel antiviral effectors within bat genomes employing a bioinformaticsdriven approach coupled with cellular and molecular virology techniques first i will perform genomic transcriptomic and phylogenomic analyses to identify the genes expressed in immune pathways and under strong positive selection during bat evolution denoting their in vivo importance second i will characterize the most promising candidates by genetic knockout and overexpression of variants in bat and human cell lines finally the antiviral activity of the candidates will be tested against a broad spectrum of viruses retroviruses positive and negativestrand rna virusestaken together the proposed project will not only identify novel antiviral factors in bats which are also active in human cells but will also shed light on the adaptive processes of chiropteran innate immunity which occurred during bat evolution
in pursuit of legality and justice minority struggles in the russian empire and the soviet union

the russian empire and the soviet union are rarely associated with the rule of law and yet the notions of legality and justice greatly mattered in both political and cultural elites invoked them as much as the wider citizenries while existing literature has addressed legality and justice in studies of state policy and intellectual opposition to the two orders there is little recognition of how instrumental they both were to ethnic and religious minorities whereas religion was one of the key determinants of rights privileges and obligations in the empire nationality understood in ethnic terms replaced religious affiliation in this capacity under socialism being part of a minority could mean open or subtle forms of discrimination yet such discrimination was neither automatic nor did it go unchallenged this project therefore explores the ways in which minorities from the russian empires great reforms of the 1860s to the dissolution of the ussr in 1991 routinely invoked and employed legality and justice to enforce their rights it argues that the systems allowed even encouraged them to do so what is more minorities were also represented among the political and cultural elites from imperial lawyers to soviet party officials what did minority actors expect when they called on justice and legality more importantly how and to which degree did this strategy help them defend their rights in two highly authoritarian states while there are obvious differences between the imperial and soviet periods in this regard there are also substantial similarities to track these the project proposes an ambitious multisited enquiry combining an analysis of published sources with extensive work in regional and central archives and oral history this groundbreaking research will also create an online database on minority legal action that will be debated with ngos and wider society in a variety of innovative knowledge transfer formats
untangling ediacaran paleomagnetism to contextualize immense global change

the ediacaranearly cambrian 635520 ma was an interval of immense global change with fundamental state shifts occurring in the biocryo and atmosphere such changes included the abrupt appearance and rapid diversification of modern metazoan life the ediacaran fauna and cambrian explosion the end of protracted globalscale glaciations snowball earth the rise of atmospheric oxygen to presentday levels and the perturbation of carbon isotopic records to extremes otherwise unknown to earth history given the immensity and abruptness of those changes they are clearly essential to an understanding of the development of life the history of climatic change and the evolution of the oxygen and carbon cycles accordingly great effort has been dedicated to acquiring detailed temporal records to investigate those changes through time but we still lack a robust paleogeographic framework to study them in space this is because paleomagnetic datawhich are used to determine the ancient positions of continentsexhibit aberrant behaviour at this time the meaning of which is unknown four alternative hypotheses have been formulated to explain them 1 rapid rotations of the entire solid earth true polar wander 2 an unstable magnetic field 3 pervasive data corruption or 4 ultrafast plate motion each of these hypotheses has farreaching implications hypotheses 1 2 4 reflect dramatic nonuniformitarian processes that would defy our understanding of geodynamics whereas hypothesis 3 poses grave challenges to the interpretation of paleomagnetic data in precambrian time my vision with epic is to investigate and identify the origins of the aberrant paleomagnetic data of this age and to use that knowledge to directly reconstruct ediacaranearly cambrian paleogeography for the first time epic will thus transform one of geophysics most outstanding enigmas into one of our greatest assets in understanding this critical time in earths development
firesafe and biobased polymer electrolytes for new generation lithiumsulfur batteries

low ionic conductivity as well as insufficient ability to suppress the shuttle effect and lithium dendrite growth has been a crucial problem constraining the development of polymer electrolytes which further leads to the fact that the vast majority of solidstate lithiumsulfur batteries sslsbs have to be operated above room temperature moreover researchers have given much more emphasis on the energy density of batteries while the firesafety property is not given as much attention as the batterys performance therefore facing these challenges the overarching target of this ambitious yet achievable project safebiobatt is to develop high energy density and firesafe sslsbs and to systematically investigate the electrochemical reaction mechanism based on these fabricated sslsbs in details crosslinking biopolymer carrageenan car a promising and potential biobased solid electrolyte with high ion conductivity at room temperature with functionalized cyclodextrin cdpcar will be produced with the aim to not only facilitate the firesafety of fabricated polymerbased electrolytes but also enhance the mechanical strength to suppress the lithium dendrite growth for their application in sslsbs the car is not only fabricated as electrolyte but also developed as binder for sulfur electrode with the aim of effectively capturing lithium polysulfides by introducing this biobased firesafe electrolyte in this project the roomtemperature polymerbased sslsb can be achievable as breakthrough furthermore lincf3so22 as a typical candidate salt will be employed in this biobased electrolyte cdpcarsalt expecting its effects in stabilizing the solid electrolyte interface and preventing the lithium dendrite as compared to the current electrolytes and key components of the batteries which mainly rely on fossilbased sources the strategy proposed here provides a safe and sustainable solution to the development of new generation firesafe batteries
novel peptidebased therapeutics for reprogramming the tumour stroma extracellular matrix using molecular modelling and computational engineering

cancer is the second biggest cause of death worldwide 90 of cancers are solid tumours where tumour stromal cells secrete a dense mass of proteins called the extracellular matrix ecm part of a protective tumour microenvironment that promotes cancer proliferation invasiveness and resistance to chemotherapy and biologics several therapies now available or being developed rely on monoclonal antibodies aimed at tumourexpressed antigens or activation of immune cells many such promising immunotherapeutic approaches fail because of this stromal barrier andor because of toxicity due to offtarget effects targeting proteins and pathways in the tumour microenvironment is now considered by oncology experts and pharmaceutical concerns to be critical to the success of beating solid tumours but no therapies have yet emerged to address this 200b market our platform uses novel molecular computational simulation models to generate small peptides that bind to highly specific sites on ecm proteins and block interactions known to promote tumour aggressiveness the first of these tax2 selectively targets a clinically relevant interaction between the ecm signalling protein thrombospondin1 and its receptors to regulate tumour proliferation vascularisation and immune cell tcell infiltration of the tumour tax2 shows extremely promising results in 15 preclinical models including ovarian pancreatic colorectal and melanoma cancers where it inhibits tumour progression and metastasis tax2 also substantially improves the efficacy of antibody therapies when combined in these models our current focus is on ovarian cancer a cancer with high unmet need and very high mortality rate eic support will enable largescale manufacture regulatory steps and firstinhuman multiindication clinical trials ph i and ph iia in preparation for outlicensing of tax2 to a pharmaceutical partner who would take the therapy through more advanced clinical trial stages
topology optimization of porous electrodes using scalable modeling approaches

redox flow batteries rfbs are a class of rechargeable electrochemical systems that are particularly promising for gridlevel electricity storage integrating the advantages of rfbs with metalair batteries results in hybrid metalair rfbs having great potential to unlock ultralowcost energy storage if certain efficiency issues are resolved in these systems porous electrodes are performancedefining components affecting the thermodynamics kinetics and transport phenomena this project proposes to develop a computational framework of metalair rfbs to optimize the architecture topology morphology and microstructure of the porous electrodes this proposal is the first to implement a multiscale computational model of metalair rfbs for accelerating the optimization of the power and electrochemical efficiency of these systems by considering the upscaling and manufacturability of the optimized designs this will be achieved by developing highperformance physicsbased computational models of metalair rfb processes in different length scales and employing them in inverse design methodologies for topology optimization of 3d porous electrodes the upscaling and prototyping strategies will be based on triply periodic minimal surface tpms metamaterial design principles that can for the first time produce highresolution multiscale and anisotropic designs of the porous electrodes prototypes will be produced using stereolithography 3d printing followed by carbonization to assess the performance of the inversely designed electrodes across different operating conditions verification validation and uncertainty quantification vvuq approaches will be used to examine the validity of the multiscale models moreover the project considers moving towards the exascale computing paradigm by leveraging proper highperformance computing hpc techniques enabling the models to simulate largescale rfb systems more accurately in high resolution
architecture function and dynamics in life sciences

architecture function and dynamics in life sciences archifun is an international doctoral programme built within the arqus european university alliance its aim is to provide a common highly qualified training background to a new generation of researchers in life sciences with a special focus on the relationships between structure function and dynamics at all levels from the atoms up to the cells organisms and ecosystems archifun dp research topics are related to destination 5 unlocking the full potential of new tools technologies and digital solutions for a healthy society of the horizon europe work programme archifun will be a successful pilot paneuropean doctoral programme which will implement the vision of the arqus alliance towards its completion in 2032 the university claude bernard lyon 1 together with u granada u padua vilnius u the technical u of munich and the national institute of chemistry of ljubljana have set up an excellent international interdisciplinary and intersectorial postgraduate programme archifun dp will gather excellent supervisors and excellent projects in integrative structural and functional biology biophysical biomedical and life sciences archifun will work in synergy with fundamental actors of the european union other than universities such as esrf the largest research infrastructure a few components of mosbri molecular scale biophysics research infrastructure a young eu project of mediumsize research infrastructures and 4 smallmedium enterprises which build the creative skeleton of euthe main objective of archifun dp as the first real eu dp is to become a knowledge hub and train responsible new citizens of the world as well as future leaders giving them the instruments and attitude to excel over and beyond life sciences once back in their own countries or wherever else in the world whether in academia public or private sector of activities
skillab monitoring the demand and supply of skills in the european labour market

the proposed project aims at a identifying skills shortages and gaps in the labor market for different regions sectorstime periods b supporting all kinds of enterprises in developing their human resource strategy including both training of current employees and skill shaping of future employees c supporting recruiting enterprises looking for specific skills d supporting eu citizens in developing their skills in an informed way and eventually finding a suitable job and e aiming to find good candidates for emerging roles but also to equip existing employees with the necessary skills to retain their jobs thus improving job retainability and reducing employee churnthe project will meet its goals by designing and implementing an intelligent platform for managing labor market skills and skill gaps the system will monitor and mine internet resources and eu initiatives to acquire and process meaningful raw data about existing and sought skills and entities offering and seeking jobs stateoftheart it technologies will be used to empower the platform and achieve its goals including advanced statistical and network and data analysis machine learning and competency mining on the basis of such analyses recommendation tools for hrm educational profile upskilling and digital policies will be made available to users the system will offer its findings in an easy humancentric with ssh principles ready to use and ethically correct form to both enterprises and individuals such objectives are highly relevant to the objectives of the call in particular it is expected that the project will contribute to the multifaceted assessment of the labor market status through its data acquiring and analysis tools continuous monitoring will allow for detecting current and future trends and gaps in requested and processed skills the platform will offer a knowledge base for recommendation tools to develop skill strategies both for enterprises and individuals
recycle repurpose and reuse endoflife wind blade composites a coupled pre and coprocessing demonstration plant

by 2030 renewable energy sources res and its infrastructures are expected to increase 40 in europe parts of res strategies are onshore and offshore wind energy the investment into new res infrastructure implies an update of the current wind turbines resulting in waste of the composite materials that constitute blades to turn res into the most promising and economically viable sources of renewable energy we need to provide clean renewable energy without any emissions during operation the blades among the most important components in the wind turbines made with composite are currently regarded as unrecyclable it is estimated that by 2050 the endoflife eol blades waste will generate more than 2 mt annually and cumulative blade waste in 2050 will lie between 214 mt and 694 mt worldwide eol options for decommissioning wind turbine blades should be explored with the aim of providing environmentally favorable guidelines for managing wind turbine blade waste and the possibility for material recovery and recycling is crucial if circular economy is the goal in the wind power sector one possibility to avoid the accumulation of eol blades in the environment is to convert the composite blades into new environmentally friendly building materials such as green cement this option would demand some processing of the composite waste another option could be the reuse of the blades directly without much processing eg as new blades or as other products furthermore the composite waste from blades could be combined with similar waste from other industrial sectors to enlarge the potential of a composite wind blade recycling processtherefore the general scope of the proposed project is to evaluate and demonstrate in large scale the possibility of recycling or resource recovery from blades and similar waste materials in a large consortium with some of europes key players in areas of importance for the project
defining the origin of barretts oesophagus by exploring a submucosal gland stem cell model

esophageal adenocarcinoma is the most rapidly increasing form of cancer in the western world characterized by short survival times its precursor lesion is barretts oesophagus which is present long before oesophageal adenocarcinoma arises this offers an opportunity for prevention however the cell of origin of barretts oesophagus is unknown this represents a huge knowledge gap and impairs the development of preventative and curative therapiesmy research has shown homeobox transcription factor hoxa13 is expressed in both barretts oesophagus and in a fraction of oesophageal submucosal gland cells but not in differentiated epithelial cells of the oesophagus or stomach the submucosal glands have been proven to have positional and mutational kinship with barretts oesophagus therefore they likely contain its cell of origin currently the only models with oesophageal submucosal gland cells are large laboratory animals these dont contain human cells are impractical costly and unethical in their use therefore i propose to establish and validate the first human 2d organoid based model of these glandsi propose to test if submucosal glands contain the hoxa13 tissue specific stem cell of barretts oesophagus by employing single cell culture and single cell visualisation techniques if proven the resulting identification of the cell of origin of barretts oesophagus would open a clear path to understanding mucosal plasticity and early stage oesophageal carcinogenesis i propose to elucidate the characteristics of this cell of origin and identify which signaling pathways mediate the emergence of barretts oesophagus the proposed host group of prof krishnadath is wellpositioned for executing this project due to their access to relevant tissues and experience with handling submucosal glands organoid technology and barretts oesophagus experimental models the results and experience gained will be instrumental for my further scientific career
sustainability and global dimension of european research infrastructures

the project is aiming at organizing a conference on research infrastructures devoted to discussing the sustainability challenge and global dimension of ri the sustainability challenge and the related funding issues will be further addressed taking stock of the developments under former presidencies notably as regards synergies between eu priorities and fundingthe conference will be organized under the auspices of the spanish presidency of the council of the european union and it will take place in tenerife during the last week of september 2023 the observatories of the instituto de astrofsica de canarias will be the main venue for this conference that will bring together the ri community from europe and beyond