Dragon09/odtu_chatbot huggingface dataset:
the natural k fe and cu isotopic response to ptbased chemotherapeutic drug resistance in ovarian cancer

cancer is the second leading cause of death globally and in the eu and was responsible for an estimated one in six deaths in 2018 early diagnosis plays an important role in determining cancer treatment outcomes but the diagnosis of ovarian cancer poses significant challenges the routine screening of asymptomatic averagerisk women is not recommended by any professional society chemotherapy using ptbased compounds eg carboplatin cisplatin is a standard treatment but tumours that are initially responsive may develop chemoresistance resulting in treatment failure the ability to predict patient response towards postoperative treatments would allow for ineffective treatments and harmful side effects to be avoided and alternative treatments to be commenced at earlier stages several mechanisms underlying tumour cell resistance have been identified so far including the altered expression of ion channels na mg k and ca and fe cu and znbinding proteins but these remain poorly understood and it is unclear whether they can be exploited as markers of resistance to that end i will apply highprecision isotopic analysis by multicollectorinductively coupled plasmamass spectrometry to fe k and cu to understand processes and determine whether changes in the natural abundances of these isotopes are associated with the development of resistance to ptbased chemotherapeutic drugs in highgrade serous ovarian cancer hgsoc the deadliest gynaecological cancer which accounts for 70 of ovarian malignancies deviations in natural isotopic abundances signal biochemical changes affecting the extent of isotopic fractionation accompanying some biochemical processes occurring as a result of a disease in a systematic and reliable way through ovarian cancer cell line tumour spheroid and hgsoc patient plasma experiments i aim to develop a revolutionary minimallyinvasive prognostic marker of ptbased chemotherapeutic drug resistance
new enabling visions and tools for endusers and stakeholders thanks to a common modeling framework towards a climate neutral and resilient society

the nevermore project is determined in supporting excellence in climate research and overcoming the current silo approach in evaluating climate change impacts and risks across sectors and adaptation and mitigation policies and measures to achieve its ambitious goals the project will develop an integrated common assessment framework consistent across scales for modelling simulating and evaluating impacts and risks of climate change as well as policy measures climate science and earth systems information 1 methods for impacts 2 and risks analysis 3 social knowledge 4 are included in the models for delivering multisectoral climate impact assessments under consistent and integrated socioeconomic and climate scenarios the nevermore approach integrates information from physical modelling of impacts and risk analysis methodologies and aligns them across different scales from national eu and global scales in the iam to local and regional scales via five case studies sitiacretegr trentinoit vsterbotten and norrbottense murciaes danube deltaro that represent various socioecological eu contexts consistency among the different scales is ensured by combining bottomup and topdown approaches the nevermore assessment framework will be embedded in a practical and userfriendly ict toolkit including decisionmaking tools designed and developed with and for different stakeholders and endusers involved throughout the project via five local and a transnational council of stakeholders by leveraging social innovation frameworks participatory processes and codesign techniques nevermores ultimate goal is to better understand the interactions between mitigation and adaptation policies and measures to deliver sound technical and policy recommendations towards a climate neutral and resilient society
literature of the postsoviet diaspora

moshkins project examines the works of postsoviet literature by writers who after the fall of the ussr left their countries of birth and established new homes in europe north america and the middle east to date these authors have been studied either as literary representatives of their adopted nations or as part of a global russian culture in which the moniker russian stands as a synecdoche for the whole postsoviet world none of these scholarly works however widened the scope of the study of postsoviet literature beyond the traditional focus on a single nation language or canon nor they have adequately grappled with the transnational affiliations and identities of exsoviet authors by putting diaspora at the center of its analytical framework this project offers a revisionist approach to the study of postsoviet literature by 1 cutting across entrenched cultural national and linguistic divides that structure the study of postsoviet literature and 2 amplifying underrepresented literary voices and identities that are frequently overlooked through a monolithic focus on russia in so doing the project produces a new understanding of postsoviet literature as inherently multilingual decentered and global to curate my research for the wider public i will build a website that will use pioneering dh tools and methods such as digital storytelling data visualization and cultural mapping to transform my findings into publicfacing scholarship with a wider appeal this will result in a better transfer of knowledge between sectors and disciplines and help foster a culture of open science
lubricantinfused surfaces in surfactant and bacterialaden turbulent flows

robust surfaces that can resist fouling reduce flow drag and control heat and mass transfer in fluctuating flows would have broad technological implications ranging from biomedical devices and marine industry to food processing and batteries slippery surfaces that use microstructures to lock in place a lubricating liquid hold great promise as a breakthrough technology in gentle conditions they have already demonstrated antifouling drag reduction and heattransfer enhancement however when submerged in harsh flow environments that contain turbulence surfactants and microorganisms these surfaces drastically change their behavior the lubricantliquid interface can break up and partially drain resulting in selfemergent surface patterns it can sustain large capillary waves resulting in surface roughness it can change or obtain new properties from marangoni stresses and it can allow the partial attachment of biofilms understanding these nonequilibrium states of lubricantinfused surfaces will lead to mitigation of failure modes and to new functionalities of lubricantinfused surfaces including controlling noncolloidal particles or serving as surface actuators therefore the aim of this project is to provide a deep understanding of lubricantliquid phenomena in harsh flow environments and lead the way to a new generation of functional surfaces for fluid flows we will use a unique combination of highperformance computing and flow experiments to untangle the interaction between the tiny scales of liquidliquid interfaces large flow patterns the existence of hidden surfactants and the active decisions made by settling bacteria by establishing the fundamental behavior of lubricantinfused surfaces in dynamic and realistic environments we pave the way to control transport processes in submerged applications
physiological adaptations to ecological niches in coccolithophore haplodiplontic life cycle

human co2 emissions are critically poisoning the earths climate however sedimentation by marine primary producers contributes greatly to carbon sequestration with coccolithophores unicellular marine algae with cell envelopes composed of caco3 being the key contributors nevertheless the extent of the biogeochemical impact of coccolithophores is largely unknown they have a dual life cycle and can grow as both haploids and diploids but past research has focused mainly on the diploid phase moreover knowledge of coccolithophores is almost exclusively limited to a single species that is distributed worldwide and can form blooms visible from space however this species is peculiar in many biological aspects and does not calcify in the haploid phase therefore we need to develop more model organisms to represent impact of coccolithophores on the carbon cyclein this action my objective is to understand how the physiological acclimations of the coccolithophore life cycle phases allow them to inhabit different ecological niches i will implement a multidisciplinary approach to investigate two levels of complexity how environmental factors influence physiology and which genes contribute to distinct genetic programs to this end i will work on a widespread coccolithophore species that calcifies at both life cycle phases i will characterize for the first time how photosynthesis lightdriven co2 fixation and photoprotection dissipation of excess energy differ between the two phases and determine which environmental conditions trigger ploidy transitions to investigate the underlying genetic factors i will then sequence the genome and in both phases the transcriptome overall the ambition of the cocconext project is to provide important insights into the interplay between life cycles ecological niches and biological co2 sequestration and beyond create novel interconnected and open datasets that will be invaluable to the oceanographic community
ip4os unpacking the possibilities of intellectual properties for open science

the main aim of ip4os is social innovation to empower multiprofessional teams and their organisations in each ofthe 27 european countries with knowledge skills awareness and advocacy to boost the valorisation of scientific knowledge in the era to a new level by promoting a concerted approach to agile ip management and os practices ip4os will 1 describe a concerted ipos approach in the synergy framework with best practices on agile ip management to support os practices 2 inform the community of practice about the synergy framework with a rolemodel campaign using advocates facts and figures 3 train multiprofessionals in agile ip management with the synergy core curriculum 4 empower multiprofessional teams in heis and rpos to use agile ip management to support os ip4os will publish and disseminate an openaccess and sound synergy framework providing recommendations for best practices the project raises 50 more awareness in the community of practice by informing about advocates facts and figures on ip tools that support os practices furthermore ip4os will reach 300 trained professionals and additionally at least 27 multipliers for multiprofessional teams from all european countries via several easytouse and sustainable educational resources using the synergy framework and the synergy core curriculumfurthermore ip4os will build a community of practice by interacting with the different stakeholders in ip and os in particular training and empowerment tasks target 15 professions divided into a ip experts and intermediaries b experts performing research and c trainers teaching ip inand research with the consortiums extensive ip and os knowledge established training and campaign infrastructure and exceptional expertise ip4os can achieve its ambitious objectives in 24 months
microwave photonic technologies for communications and sensing applications in space

a revolution is taking place in the field of satellite systems as more satellites have been launched into orbit in the last 5 years then in the last 6 decades combined the main reason for this is because satellites are now affordable to manufacture and the new generation of satellites orbit at much lower altitudes sparking new opportunities in communications and earth observations eothe mwp4space idn will train the next generation of specialists in integrated microwave photonic imwp devices and systems in the framework of satellite and space applications they will gain skills to integrate compact photonic and radio frequency rf circuits and cuttingedge knowledge of photonic integrated circuit pic design fabrication packaging validation and qualification both at the device and system level competences for which there is a fastgrowing demand in the global satellite industry but that are rarely taught in an integrated training program importantly those skills are deemed essential to achieve the scientific goals of the program which are to develop introduce and promote imwp technologies for secure and reconfigurable networks of leo and meo satellites for telecommunications satcom and eo mwp4space will offer a unique education program for 15 young researchers structured in research projects and networkwide training activities and delivered by 6 european universities 1 nonprofit academic research institutions and 9 companies which are worldclass references in both photonics and space technologies by positioning mwp4space dcs as key actors in the transfer of knowledge developed for terrestrial applications to space applications our training network will significantly contribute to their employability by placing them as future leaders in the next generation of satcom and eo technologies
multiparametric evaluation of osteosarcopenia disease using magnetic resonance imaging

osteosarcopenia osp is a recently recognized pathology of aging defined as the cooccurrence of osteopeniaosteoporosis op andsarcopenia sp leading to high morbidity disability and mortality with an associated tremendous economic burden there are noapproved therapies specifically targeting osp it is critical to monitor osp pathophysiology progression and response to therapyholistically by simultaneously measuring effective quantitative biomarkers sensitive to early changes in tissues to provide meaningfulinformation on various mechanisms involved in ospas an msca fellow dr barbieri will exploit crucial training at i the university of bologna host institution ii rizzoli orthopedic institute associated partment linked to the beneficiary and stanford university associated partner during a secondment of 8 months the excellent network of mentors and participant organizations will ensure the success of the overarching overall objective of the projectto propose technical advancements in magnetic resonance imaging mri sequences protocols and processing to overcome thecurrent limitations of mribased assessment of cortical and trabecular porosities and to use a multiparametric approach to studyassociation of bone and muscle quality biomarkers in postmenopausal osteoporotic and osteosarcopenic women the specificsobjectives are 1 to develop a rapid mri sequence to measure cortical and trabecular porosities which is not currently feasible 2 todevelop a clinically feasible mri protocol to map muscle and bone quality and 3 to assess the association between bone biomarkersand muscle quality biomarkers in op and osp womenthe excellent technical expertise paired with training in clinical imaging will allow dr barbieri to produce a new mri sequence to bedeployed open access a new multiparametric approach to study osp information on bone and muscle biomarkers association anddissemination to crucial target audiences
advancements in social economy through technological solutions

the social economy se sector constitutes over 10 of all eu enterprises sustaining around 136 million job positions despite its significant role social economy organizations seos face substantial policy and legal challenges including funding shortfalls and difficulties in scaling underscoring the need for thorough investigation while often acknowledged as innovative contributors to social inclusion some criticize them for allegedly advancing a neoliberal agenda controversies persist primarily due to challenges in measuring the social impact of seos and discerning their outcomes compared to mainstream social inclusion providers to delve into this discussion there is a pressing need to enhance evaluation tools for measuring the impact of se on social inclusion although various approaches exist they are primarily linked to improved accountability and external evaluation guidelines commonly overlooking local needs and specificities concurrently transnational reports indicate that se employees on average receive lower compensation experience more precarious jobs and face informal working conditions therefore there is an urgent need to broaden the scope of social impact assessment beyond service beneficiaries incorporating the impact on se employees in this context technological advancements hold the potential to support se progression with platform cooperatives emerging as influential contributors committed to citizen involvement and improving members working conditions through collaborative governance against these backdrops assets employs a fourstep strategy to explore ses impact on social inclusion quality job provision and sustainability conducting research and case studies spanning regions both within and outside the european union improving evaluation tools through local integration and technological advancements and creating a digital collaborative platform to engage stakeholders and enhance working conditions within se
deciphering the structure and functions of the soil microbiome of exotic plantation of a changing world exofun

over the centuries exotic trees have been planted worldwide for the rehabilitation of degraded lands and to obtain financial benefits from wood paper production tannins ornamental assets however despite being evolutionary nave to the new environment outcompete the locally adapted native plants in resource acquisition displace the native vegetation and may become invasive species while the influence of exotic plantations on native vegetation structure and community composition is well documented surprisingly much less is known about how exotic tree plantations have altered the structure and function of the soil microbiome although soil conservation is integral for the achievement of socioecological sustainability a comprehensive study focused on the biogeographical comparisons of cyclic linkages between exotic plants and soil microbes and its influence on the multiple ecosystem functions is lacking this is urgently needed to better understand the impacts of exotic plantations on biodiversity and function along with interaction with other global change drivers such as climate change using eucalyptus globulis and pinus pinea as our model exotic tree species the main aim of exofun is to understand the influence of exotic plantations on the structure and function of the soil microbiome at a crosscontinental scale by combining observational studies and greenhouse experiments how do exotic tree plantations influence carbon sequestration soil biodiversity maintenance and the capacity of ecosystems to response to climate change compared with native forests in the current undecade of ecosystem restoration the outcomes of this project will help to understand that to what extent the plantation of the exotic species be allowed or should we completely replace it with native plants to maximize the ecosystem services the outcome will also contribute to the european mission soil deal for europe to protect and restore soil across europe by 2030
switching polytypes and symmetries by discrete vdw sliding

while the artificial design of pristine crystalline structures and the construction of dedicated periodic playgrounds for atoms and electrons in a solid have transformed our world much is yet to be explored i posit that the marvels of van der waals polytypes should go much beyond and suggest that they offer a remarkable opportunity to rapidly efficiently and distinctively swap between numerous different crystals symmetries and dispersions at willwe have recently reported several new crystals made from identical 2d layers that differ only by their stacking symmetry these perfectly commensurate and periodic diatomic polytypes result in distinct electric potential steps and exclusive ladderlike polarizations owing to their various combinations of broken inversion and mirror symmetries our current research focus is monoatomic polytypes that break both symmetries and offer further fundamental insight into the purely geometric impact of the atomic positions in the unit cell our preliminary experiments on graphitic polytypes detect novel internal polarizations placing us in a great position to explore its interplay with superconductivity and orbital magnetizationthe key challenge is to break the polytypes out of their commensurate metastable stacking and force the layers to slide at particular interfaces only along armchair lattice orientation and for discrete interatomic distances we have recently observed that such switching is possible using external electric fields but only in the case of polar diatomic bilayers the swapping involves a thin incommensurate boundary wall encompassing a single stacking fault which may slide rapidly in a superlubric mannerbuilding on our ability to construct and distinguish adjacent polytypes we aim to develop methods to efficiently switch between many distinctive polytypes and properties with robust nanometer and nanosecond swapping capabilities we envision groundbreaking slidetronic technologies
telerehabilitation of balance clinical and economic decision support system

telerehab dss targets the promotion of ai adoption in everyday clinical practice for balance rehabilitation training an aibased decision support system dss will be developed expanding upon the existing augmented reality ar rehabilitation training platform with its balance exercises exergames cognitive training and remote patient monitoring with wearables and iot devices from holobalance project tl6 to provide suggestive feedback for experts through the entire clinical rehabilitation pathway the first component of ai models of telerehab dss will assess prognostic factors for risk of falls treatment effectiveness outcomes and side effects at baseline level using a high volume of retrospective data for initial training the other ai pillar of telerehab dss will introduce automated balance intervention planning and management functionality the dss will provide for each patient an optimal set of personalised rehabilitation activities considering the best clinically effective treatment in conjunction with socioeconomic effectiveness and ehealth literacy the later will be evaluated with a quick and easy to use tool with simple tasks to assess patients level of technological awareness ie use of smart devices ar and iot equipment in order to predict if this is going to affect compliance and adherence with interventions that rely on the use of such novel technologies finally the most beneficial use of ai in telerehab dss will consist of automated remote patient monitoring with wearables and iot sensing devices allowing rehabilitation training programs to be performed at home the dss will evaluate in realtime patient performance symptoms occurrence with virtual ar physios providing corrective and motivational feedback as activities are performed these performance evaluation measures will be fed back to the dss to support experts with their most time and effortconsuming activities of daytoday patient management