Dragon09/odtu_chatbot huggingface dataset:
advanced technologies for high value imaging applications

new strategic and growing markets related to connectivity mobility automotive health and earth monitoring call for improved imaging solutions in visible lwir and vlwir offering advanced functionalities and cost effectiveness visible imagers market is currently largely dominated by noneuropean countries lwir bolometers imagers fabricated aboveic have not yet been democratized for high volume markets due to the difficulty to solve performance versus cost equation however asian providers are making important progress to tackle this challengeathena aims at strengthening european economy in hightech imaging technologies by taking advantage of 3d stacking technologies improved sensorprocessing integration multimodal 2d3d functionalities by preparing the manufacturing of bolometers from 200mm to 300mm cmos wafers for productivity gain and access to more advanced cmos nodes for improved functionalities developing cost effective lwir wafer level optic solutions by using new methods of growing and doping materials for future vlwir imager manufacturabilitythis will foster new applications related to automated systems in industry border and security management health and consumer markets and earth climate monitoringathena gathers a strong european consortium composed of highly renowned research technological organizations big industrial players in imaging technologies and endusers to specify design develop test these technologies in use cases and set common specifications for the imagers to support their industrialization and widespread adoptionin line with both the european unions chips act and the electronics components and systems strategic research and innovation agenda athena will not only address the development of new sensors and chips but also their integration in larger systems to pave the way to promising applications athena will strongly contribute to europe leadership industrial competitiveness and sovereignty
deciphering cellular and molecular mechanisms of cell regeneration

glucagonlike peptide 1 glp1 therapy was shown to regenerate cells in mice but this did not translate to human early or intensive insulin therapy maintains residual cell function but also causes weight gain and hypoglycaemia thus currently no drug treatment can safely stop the progression of diabetes a disease characterized by loss or dysfunction of insulinproducing cellsin breakthrough discoveries we identified the insulin inhibitory receptor inceptor as a druggable target for cell insulin sensitization and protection without the sideeffects of insulin moreover we combined glp1mediated safe cell delivery of estrogen together with 60 reduced insulin therapy to restore cell function for diabetes remission the overarching goal of betaregeneration is to explore new avenues of targeted and combinatorial cell protection and regeneration therapyin aim 1 we will reveal whether inceptor beside desensitizing the insulin receptor has also a function as insulin receptor in starvationstressinduced insulin degradation and as scavenger receptor for insulin lysosomal degradation this will reveal if inceptor can be targeted to enhance cell insulin sensitization secretion and functionin aim 2 we will translate our basic findings to in vivo animal and human model systems to explore glp1mediated cell delivery and targeting of wnt and cell insulinigf1 signaling to enhance specificity and target several pathways at once furthermore we will genetically and pharmacologically target inceptor and test if monoclonal antibodies alone or as drug conjugates can promote cell protection and regeneration our approach will reveal if combinatorial targeting of survival and regenerative pathways can stop cell loss and dysfunctiontaken together the identification of clinically relevant targets and ways of combinatorial cell protection and regeneration therapy could open new avenues to stop and revert diabetes progression
the role of microbes in aquaculture understanding the functional role of oyster microbiomes in response to changing climates and diseases

bivalves are ecologically and economically important in europe oysters in particular provide ecological benefits through habitat provision economic benefits through aquaculture production and societal benefits through cultural associations although of high importance oyster production is threatened by changing climates and disease proliferation which cause mass mortality events recent advancements show that microbiomes the microbial community within a host organism play a significant role in the functioning of the host and their resistance to adverse conditions this project will incorporate knowledge from the fields of global change ecology shellfish health and diseases and microbiology to increase the understanding of the role of the oyster microbiome in resistance to threats posed by climate change and disease proliferation as well as the overall performance of oysters in the environment by combining field and laboratory investigations of how the physical environment affects microbial functioning within oysters produced by both wild and hatchery based stocks and subsequently their susceptibility to pathogens this project will provide a holistic indepth understanding of the contribution of such microscopic organisms to these valuable bivalve species results will be beneficial to the scientific community aquaculture stakeholders policy makers and coastal societies alike project outcomes will move forward the integration of microbiology into the success of aquaculture to increase production sustainability and blue growth
atomic force microscopybased exploration of layered double hydroxide nanoparticles adjuvant mechanism

layered double hydroxides nanoparticles ldh nps composed by divalenttrivalent metal ions are efficient vaccine adjuvants to assist antigens to induce potent humoral and cellular immunity however the adjuvant mechanisms of ldh nps still remains elusive since the metal ion species and ratio are closely related to the adjuvant activity of ldh nps this study will investigate how the metal ion composition will affect the adjuvant activity of ldh nps then an atomic force microscopy afmbased approach to physicomechanically map the specific interaction occurring between np and tolllike receptor4 or scavenger receptor a1 in vitro on living cells finally the adjuvant signaling pathways of ldh nps will be investigated in antigen presenting cells this study will greatly advance the knowledge on the interplay among nanomaterials and innate immunity the singlecell quantitative approach can be readily applied to study the binding of other nanomaterials and the testing of antiinflammatory molecules on living cells of the innate immune system
medicine made to measure

modern medicine seeks to personalize diagnosis and treatment to the needs of individual patients this need is heightened in particular for those individual patients where no treatments are available and where current standard treatment development paradigms exclude to generate such the ultimate goal of medicine made to measure mmm is to go even beyond the latest genetic medicine approaches implementing a novel paradigm of treatment development the field of single patient tailored antisense oligonucleotide aso treatments for patients with nanorare disease mutations specifically mmm will develop core modules of a novel outofthebox but still emaadvised treatment development path for these patients from omicsbased theranostics via preclinical target validation to innovative trial methodology and a pioneering ethical framework for individualised genetic therapies mmm provides a unique opportunity for doctoral candidates to be involved in building and to receive training in all core modules needed for tailored aso treatment in europe this new scientific field requires a new generation of openminded technologyfluent and applicationsoriented experts mmm will help educate future drug development and translational experts in adopting and disseminating such a crossspecialty approach our idea for this innovative training network is built on our personal experience and understanding of the importance of single patient tailored genetic treatments in the years to come we propose a consortium of worldleading experts and partners that present with extended experience and relevant knowhow in molecular biology neurology translational medicine biochemistry bioinformatics philosophy mathematics regulatory science and engineering thus mmm provides an exceptional platform to young ambitious and talented researchers who like to engage in supporting the concept of single patient tailored treatments
relativistic spin hydrodynamics theory and applications

this proposal establishes connections between fluid dynamics quantum field theory and mathematical physics to develop new tools to better characterise outofequilibrium properties of relativistic quantum manybody systems my work is instrumental to understand the emergence of novel fluidlike behaviours which are not apparent in the fundamental laws the focus of my research is the quarkgluon plasma qgp an exotic phase of quantum chromodynamics qcd where quarks and gluons are not confined inside of nucleons the qgp is formed in relativistic heavyion collisions performed at the large hadron collider lhc and the relativistic heavy ion collider rhic a huge surprise was the discovery that the qgp behaves as a relativistic liquid with very special properties namely it flows with the lowest specific viscosity of any known liquid and it is by far the system with the largest vorticity ever observed such large vorticity triggers particle polarisation which is a phenomenon resembling the magnetisation displayed by a ferromagnet that is spinning around an axis this effect shows the interplay between a macroscopic quantity the fluid rotation and a microscopic quantity which is inherently of quantum nature the spin of the particles the recent observation of polarisation phenomena of hadrons emitted from the rotating qgp in heavyion collisions calls for a new formulation of relativistic fluids where spin degrees of freedom are crucial to the dynamics this is called relativistic spin hydrodynamics despite fluid dynamics being an old subject the formulation of the full causal and stable theory of relativistic spin hydrodynamics which can be used for theoretical predictions is yet to be developedexpected outcomes from this proposal include the formulation of causal and stable theories of relativistic spin hydrodynamics their extensions to the farfromequilibrium regime applications to qgp physics
controling 3daromaticity by switchable molecular tweezers

aromaticity a fundamental concept in the field of chemistry is conventionally associated with planar conjugated twodimensional 2d systems despite its theoretical description and potential application in optoelectronic materials 3d aromaticity induced by strong through space frontier orbital interactions remains so far little explored aromaswitch aims to exploit the complementary expertise and knowhow of the host institute and the fellow to delineate the concept of controlling spatial conjugation by the mechanical motion of switchable molecular tweezers our hypothesis is that using niiiporphyrin andor norcorrole to place persistent enriched electron at both ends of a tweezer will a generate threedimensional through space conjugation in an optimized distance between two facetoface oriented macrocycles and b influence the resultant antiaromatic character of the whole system this approach is innovative as such through space conjugation has not yet been explored in the molecular tweezer we will develop macrocyclesterminated switchable molecular tweezers i to tweak the through space electronic conjugation in an on and off mode and ii to investigate the impact of 3d conjugation on aromatic propertydriven photophysical and electrochemical properties in addition we will iii inspect the threecomponent tweezer systems in the context of the guest binding study intercalation of aromatic or antiaromatic motifs and optoelectronics applications the project will thus enhance our understanding of stimuliresponsive and conformationdependent 3d communication between antiaromatic rings and holds great potential for the development of smart materials with an optoelectronic response
the next generation innovation talents initiative

in todays fastpaced global landscape innovation is the catalyst for progress the next gen innovation talent initiative is dedicated to fostering a cohort of skilled entrepreneurial thinkers who can translate ideas into tangible marketready solutionsour mission is clear to nurture an entrepreneurial mindset among researchers and emerging innovators we view innovation as more than just generating ideas its a rigorous process of turning those ideas into practical marketready solutionsto achieve this weve designed a comprehensive twoyear program based on a robust and flexible methodology that leverages cuttingedge ai instruments to support the program it begins with discovering talents and a detailed needs assessment for each participant providing valuable insights into their unique aspirations we then facilitate connections between researchers and the corporate world using an intelligent matching procedure creating an environment encouraging collaboration and creativityparticipants in our program are not ordinary interns they are the future architects of innovation and problemsolving from the most relevant european research programs eg erc and eic we provide robust support through mentorship resources and tailored opportunities empowering them to envision ambitious goals and overcome obstacles in pursuing transformative solutionswe aim to quantify our impact through a target of no less than 600 internships each representing a distinct personal and professional growth journey our ultimate aspiration is to witness the birth of groundbreaking inventions the rise of visionary leaders and the establishment of a culture where innovation and society thrive
reenvisioning risk biomarkers in acute myeloid leukemia aml at singlecell level

acute myeloid leukemia aml is one of the most aggressive clinically and biologically heterogenenous hematological alignancies the different genetics classify disease entities and define the prognostic risk category to which aml patients are assigned and the treatment choicesthere is one entity the aml with nucleophosmin npm1 gene mutations that accounts for onethird of all adult aml the most frequent and where another gene mutation the fmslike tyrosine kinase 3 flt3internal tandem duplication itd acts as tip of the balance for patients risk definition drastically worsening the prognosis and hanging treatment in those 40 of patients where it is detected this has been a main field of research of prof maria paola martelli and her team since years and specifically of her erc consolidator grant contranpm1aml here she will exploit concepts stemming from her erc funded studies on the key role of kinases in the npm1mutated aml development response to therapy and initiating relapse and focus on that 60 of patients regarded at favorable prognosis who nevertheless in 40 of cases will relapse with extremely dismal outcome currently successful strategies to identify novel frontline key markers to refine risk are not available remarkaml takes the challenge and changes prognostic risk parameters pointing at reenvisioning the marker at singlecell level a first strategy has been designed and will be tested for the proofofconcept in patients in a prospective noninterventional study we have established contacts with industrial partners for the development of fitforpurpose diagnostic assay prototypes to test then in the study the success of remarkaml will open the next challenge of developing marketable diagnostic kits and defining a strong business plan in order to measure the impact of our idea and poc in the realworld clinical setting
advancing research innovation of forth in green soft matter

a broad range of widely used industrial products consist of complex soft matter systems polymers colloids emulsions etc madeup of synthetic ingredients of high environmental footprint urgent societal needs embodied in the european green deal require the replacement of synthetic components by green environmentallyfriendly counterparts the transition to green materials is of vital importance for the transformation towards a sustainable ecofriendly production and a highly needed circular economy and sustainable growthforgreensoft aims at advancing the research capacity of forth in the area of green biobased soft materials by transferring knowledge from three worldleading institutions in the field of green chemistry max planck of colloids and interfaces as well as in specific experimental and computational methods max planck for polymer research and university of vienna the later are vital in a leading research activity in green soft matter but are lacking in the host institute forgreensoft research objectives will be achieved by a wellbalanced training and personnel exchange program as well as a collaborative research program focusing on two key applications green antifouling coatings and water desalination membranes in parallel forgreensoft aims at enhancing the networking activities of forth and improving its capacity to successfully participate in a wider range of eu calls to attract industrial funding and to promote innovation these objectives will be reached by transferring expertise from the leading partners via the training of forths personnel in soft skills and by local restructuring measures such as the creation of an industryacademia liaison office focused on green soft matter applications moreover the leading partners will benefit by establishing new scientific collaborations with forth on promising research directions and by extending their expertise in fields in which forth has an established research record
future raw materials demand supply and sustainability in the face of climate change

rawclics main goal is to develop knowledge on the future raw materials rms demand supply and associated environmental impacts induced by the twin transition in the eu and to support factbased industry and policy decisionmaking enabling this transition rawclic revolutionizes the development and analysis of likely future scenarios of rms demand and supply considering challenges and opportunities as to material substitution future rms potential geological and urban mine deposits processing technologies circular use of materials geopolitical shifts and induced environmental impacts it enables to identify the i challenges and associated risks to supply ii opportunities and iii potential mitigation measures at technology sectoral and eulevels it improves and expands existing models and develops new ones to assess and analyse the future demand wp2 supply from secondary wp3 and primary wp4 sources and environmental effects including climate change waste generation land and water use and biodiversity impacts wp5 the models are applied to a selection of 20 rms justified in the context of the twin transition while ensuring replicability for future modelling exercises modelling activities are harmonized wp1 and integrated into pathways and strategies facilitating the twin transition while accounting for crucial risks regarding rms bottlenecks wp6 rawclic ultimately develops a coherent roadmap for global decision makers working in research policy and industry to achieve the twin transition industry stakeholders from across the value chain of the focus rms are in regular dialogue with the project in a mutuallybeneficial collaboration wp7 this includes engagement with downstream industries in energy and digital technologies to support their resilience and with upstream mining and refining stakeholders to support their decarbonisation objectives
conversational systems for emotional support and customer assistance

crystal conversational systems for emotional support and customer assistance will advance research for a next generation of conversational models and systems that implement reliable friendly and efficient humanmachine interactions that can assist humans in tasks beyond automatic information provision such as emotional support as well as customer assistance emotional support provided to vulnerable individuals such as ageing adults or people experiencing anxiety or depression advanced customer assistance provided to call centres providing customer care and response to customer inquiries in an empathic inviting accurate and efficient manner conversational models and systems will be developed by proposing novel learning strategies for domain adaptation exploring large language models llms and prompt engineering methodologies user state estimation will be also considered and strategies such as behavioural models and stakeholder goals will guide the policies for dialogue management novel evaluation frameworks will be also designed by including automatic metrics usability as well as human acceptance of the technology strict ethical and ai robustness compliance procedures will be applied as conversational recordings will be collected anonymised annotated and encrypted for collaborative work among the project partners the project will apply extensive staff secondments and foster sustainable knowledge exchange it will grow the experiences and insights of the partner organisations staff via intersectoral and interdisciplinary collaborations implemented through secondments as well as training and networking activities dissemination communication and exploitation activities will expand the projects impact pathways
terravision integrated earth observation based platform for novel services to enhance raw materials mining life cycle

terravision will establish and deploy an integrated platform to enhance the entire critical raw materials value chain towards implementing sustainable mining practices terravision earth observation eo mining services platform will be supported by 4 innovation pillars i the data ecosystem for large scale eo mining services will link and exploit various data from key sources eg copernicus satelliteground radardroneinsitu sensing data for monitoring the entire raw materials life cycle ii the analysis ready data and raw material spectral library will provide a novel framework for processing raw multisensory eo data to become analysis ready data and to be combined semantically with insitu data to enable the development of an open and standardised raw material spectral library to support the full mining life cycle of critical raw materials and the mapping of primary and secondary critical raw materialsiii the eo services for the mining industry will develop and deploy services critical to supply chain eg mapping of critical raw materials mineral exploration extraction rates in opencast mines and stockpile volumes but also enable a dynamic hazard mapping service for proactive management of risks to promote operational efficiency of mining sites iv the green resilience accountability component will promote critical raw materials supply chain resilience and sustainability based on the quantification of environmental and socioeconomic impact of mining activities for different mining phases eg permission operation postclosure the effectiveness of the terravision eo mining services platform will be demonstrated at both eu greece spain and beyond coupled by validation campaigns at 6 mining sites that will pave the way for rapid uptake of the proposed systemic innovations targeted dissemination exploitation and replication activities will enhance a clear pathway for terravision towards significant euwide impact