Dragon09/odtu_chatbot huggingface dataset:
microelectronics reliability driven by artificial intelligence

the european microelectronics me industry has a direct impact on approximately 20 of the european gdp and employs over 250000 people with more than 64000 job vacancies the main technological challenges are 1 to increase both the reliability of the manufactured electronic components and systems ecs and sustainability to meet the requirements of the new eu directive right to repair and 2 to reduce the huge product verification effort 70 of total product development time that represents a substantial burden on costs and resources to compete with china and north america the european me industry is in critical need of crossdiscipline experts in electronic manufacturing and digital innovations software data and artificial intelligence the main goal of the mirelai industrial doctorate programme is to train the next generation of engineers and scientists for the next generation of reliable and repairable ecs developed within a trustworthy european value chain the scientific approach is based on three pillars 1 physics of degradation 2 multiscale modeling and 3 aibased reliability which in sum will add up to a reinvention and new level of efficiency for the design for repair and reliability for ecsour unique industryacademia partnership of 8 industries 4 smes and 9 research organisations and academic institutions from 7 european countries has all the expertise experience and capacity along the electronics system value chain to deliver this ambitious research and training programme shared hosting and joint supervision by industry and academia of each of the 13 doctoral candidates ensures optimal knowledge transfer together we will pave the way for sustainable repairable and energy efficient electronic system designs and resourcefriendly smart electronics applications mirelai is thus perfectly aligned with the european research agenda and the eu pact for skills a shared engagement model for skills development in europe
precision medicine approach to rare vascular malformations to enhance understanding diagnostics and therapy

vascular malformations are clinically very heterogeneous ranging from small local birthmarks to lifethreatening entities affecting entire limbs organs or larger parts of the human body often these conditions require surgical andor pharmacological intervention to prevent further disease progression and to increase patients quality of life therefore an accurate diagnosis is crucial for appropriate treatment and management however our current knowledge on vascular malformations is very limited making diagnosis and treatment very difficult due to 1 an inadequate understanding of the underlying histological alterations causing the phenotype 2 very limited genetic diagnostic testing which in most cases does not allow a confirmed molecular diagnosis 3 poor curative surgical and pharmacological treatment approaches as the current pharmacological therapy regimen with drugs from oncology or transplantation medicine is more like a try error than a precision medicine approach there is a high risk of drug side effects and nonresponse to therapy and thus progression of the disease i want to tackle these obstacles with a multidisciplinary approach to precision medicine for vascular malformations to prevent disease progression and improve patient outcomes thereforemy proposed workflow provides 1 a novel histological classification based on deep phenotyping using diagnostic aiassisted 3dhistology 2 improved diagnostic testing through analysis of the coding and noncoding genome using stateoftheart sequencing techniques and bioinformatics tools and 3 patienttailored pharmacological treatments based on fdaapproved drug sublibrary screenings tested on the patientderived cells using stateoftheart imaging techniques this innovative approach to precision medicine has the great potential to transform clinical practice and provide for the very first time stateoftheart diagnosis and treatment for patients with vascular malformations
resilient media for democracy in the digital age

resilient media for democracy in the digital age remed responds to the european commissions call horizoncl22022democracy0106 media for democracy democratic media and will tackle existing challenges to a healthy relationship between media and democracy by taking a bold approach to improve relations between citizens media and digital technologies with an interdisciplinary approach and an innovative methodology that combines qualitative and quantitative methods remed will gather analyze compare and contrast data on professional journalists alternative media content producers and citizens operating in technologically mediated configurations and on the media organizations market structures and national and international regulations that underpin media production circulation and consumption in the contemporary media landscape remed will work closely with all parties involved in order to coproduce highimpact knowledge and solutions that will contribute to the creation of resilient democratic media that reinvigorate strengthen and uphold democracy the rule of law and fundamental human rights the project is particularly timely as remeds results and policy recommendations will feed directly into the contemporary debates around the design and implementation of the digital services act and digital markets act
advancing databased policymaking in urban and regional development and widescale implementation for sustainable environments

urwise aims to achieve longterm excellence institutional recognition visibility and better integration of the host institution feun in the european research area led by era chair holder the project seeks to foster competitiveness in research funding by promoting institutional reforms at both system and organisational level it aims to establish a permanent and excellent research group in the field of databased policy analytics for resilient urban and regional development this is to be achieved through clearly defined and measurable specific objectives establish an excellent research group fostering brain circulation and intersectoral mobility to create brain gain for feun by increasing the number of ri professionals relocated to era team and placing a strong emphasis on international interdisciplinary and intersectoral mobility implement structural changes at feun to enhance its institutional framework by joining international networks and associations forming alliances with economic faculties and establishing partnerships with researchintensive institutions increase feuns research excellence and profile in datadriven policy analytics through training opportunities mentorship programs and collaboration with global partners enact organisational changes to enhance contributions to knowledgebased economy and secure competitive research funds by upgrading research infrastructure founding research institute and forming partnerships with technology park conduct a series of research to enhance feuns capacity for policy advising at local and national levels by utilising a multifaceted methodology integrating spatial analysis citizen engagement and multidimensional evaluation techniquesthe project leverages the era chair holders international network to establish collaborations foster research excellence and attract outstanding scientists thereby addressing the need for more and better links between ri actors across the era
targeting macropinocytosis in glioblastoma to achieve precision medicine

tumors must survive microenvironmental stresses such as nutriment deprivation low levels of oxygen and anticancer treatments to do so tumor cells have developed numerous adaptation mechanisms and we have recently shown that induction of macropinocytosis is associated with tumor cell survival in our previous work we determined that the galectin3 gal3krasalphavbeta3 integrin complex acts as a driver of macropinocytosis an endocytic process by which tumor cells are able to engulf large amounts of nutrients from the local microenvironment in glioblastoma gbm cells which do not harbor mutations in kras we interestingly uncovered the same phenomenon of macropinocytosis induction which was associated with the mesenchymal subset of gbm my recent work challenged this paradigm of oncogenes such as oncogenic kras essentiality for macropinocytosis activity in cancer cells although the mesenchymal subset is associated with variable expression of several genes a molecular signature rather than a mutation in a single oncogene defines macropinocytosis in this context we also found gal3 to be involved in macropinocytosis induction in mesenchymal gbm cells confirming the central role of gal3 in this process altogether my results demonstrate that induction of macropinocytosis is not restricted to tumors bearing mutations in specific oncogenes but can potentially be a universal scavenger process used by tumor cells to survive environmental stress in this context the overarching goal of this proposal is to define the molecular mechanisms underlying cancer cell addiction to macropinocytosis with the ultimate aim to identify targets for the therapeutic exploitation of this mechanism to achieve this goal we will combine various functional assays metabolomic transcriptomic and proteomic analyses with a cuttingedge technique of laser capture microdissection together with massspectrometryguided protein identification of the macropinosomes
cobalt and lithium speciation toxicity and bacterial community regulations at the sedimentwaterinterface

in the eu transport is responsible for a quarter of greenhouse gas emissions for the transition to a climate neutral economy battery development and production strategies are thus important by 2030 the eu expects an increased requirement of 18 times more lithium and 5 times more cobalt these elements are released into the aquatic environment by mining processes and wastewater discharge in aquatic systems sediments are important and dynamic sinks or sources for such elements depending on varying environmental conditions the chemical state bioavailability and toxicity of these elements in aquatic systems is highly influenced by environmental parameters such as ph and temperature which in turn are influenced by climate change the goal is to investigate the toxicity of lithium and cobalt in aquatic systems under different environmental conditions this will be addressed in 3 research objectives 1 investigation of the impact of temperature and ph on the distribution and chemical characteristics of lithium and cobalt within aquatic systems 2 analysis of toxic effects of lithium and cobalt to zebrafish 3 evaluation of lithium and cobalt related microbial community changes within the sediment to address these objectives we will perform a longterm exposure with zebrafish to selected sediments spiked with lithium and cobalt in an aquarium system capable of monitoring and regulating different water parameters the toxicity will be determined with the zebrafish embryo toxicity test geneexpression analysis will reveal sublethal toxic effects of the selected elements bioaccumulation and content of lithium and cobalt in water and sediment will be quantified by icpms changes in the sediment microbial community will be investigated by metagenome fingerprinting with this interdisciplinary holistic approach we aim to improve environmental risk assessment of sediments contaminated with lithium and cobalt particularly in regard to climate change
cognitive deficits resulting from selective vulnerability of septal inhibitory neurons mitochondrial dysfunction as a driver

septal gabaergic projection neurons are considered pacemaker cells as they enable the temporal organization of neuronal spike firing in hippocampal and entorhinal networks that support spatial and objectcoding accordingly medial septum inactivation is associated with cognitive impairments but the specific role of the septalentorhinal gabaergic projections therein has remained unexplored this is a pressing question as we have evidence that septal gabaergic projections exhibit enhanced vulnerability in mouse models with neurodegeneration we found that septal gabaergic axons exhibit signs of degeneration when target cells in the entorhinal cortices are not yet impaired furthermore we have evidence for mitochondrial pathology in the degenerating axons these results prompt the following questions how does malfunction of septal gabaergic projections translate into dysfunction of downstream networks involved in episodic memory and spatial navigation what are the mechanisms that render septal gabaergic projections prone to vulnerabilityemploying in vivo electrophysiology combined with optogenetics behavioral studies 2photon imaging of axons and mitochondria in live mice and spatial transcriptomics we will tackle the following issues a assess how impaired septal gabaergic projections affect spatial and objectcoding in the medial and lateral entorhinal cortex mec and lec b assess the functional consequence thereof on spatial and associative memory in the lec c gauge putative cellular mechanisms with focus on mitochondria that render septal longrange gabaergic projections vulnerable and d identify genesgene networks whose expression is involved in degeneration of septal gabaergic neuron axons with these studies we will elucidate how septal neurons contribute to cognition reveal common mechanisms for axonal degeneration and ideally identify novel biomarkers and therapeutic targets for mitochondropathies
protecting european public spaces against emergent hostile drone threats through an advanced multidimensional shield and crossborder intelligence

preserve will deliver a trustworthy transparent and easytouse hybrid cuas c2 platform supporting police authorities with the prevention early detection and optimal management of operational response against current and emergent threats in drone technology increasing the security of citizens in public spaces and contributing significantly to the novel eu counteruas policy by fusing heterogeneous data from an array of physical sensors and online sources the project will tackle the so far unmanageable threat of weaponised consumer drone swarms through opensource knowledge by nonstate actors preserve will produce s multidimensional shield synthesised into four products swarmbased cuas arsenal p1secure online drone intelligence engine odin the preserve platform p3 as the integral solution and the cuav training programme p4preserve platform and products will be validated in nearreal environments targeting specific pilot usecases puc where the real needs expressed by the endusers will be addressed the flexible and scalable architecture of the preserve platform will allow endusers to implement the platform as a whole or to adopt only specific services and tools based on their operational needs theoretical and practical unitarcertified trainings handson experience tabletop exercises and field fullscale exercises will boost the uptake of preserve products the platform development will be governed by ethics privacybydesign and aitrustworthiness considering eu and relevant national legislations as well as societal aspects with four police authorities six research institutions four industry partners including three smes two regulatory policy standard and social experts and two affiliated entities the preserve consortium delivers a strong multidisciplinary combination of expertise and novel technologies to meet its objectives
innovative decisionmaking tool for defining the most suitable manure management strategies to achieve a sustainable livestock farming system during the whole value chain

livestock farming is a key sector that involves 40 of the total agricultural activity in europe representing a total value for products equal to 170 billion however there is an increasing concern due to livestock farmings contribution to environmental pollution since it generates more than 14 billion tonnesyear of manure leading to significant greenhouse gases ghg and air pollutants emissionsnh3 noxas well as to soil and water contamination caused by hazardous manure chemicals and biological contaminants called here emerging contaminants in this context extensive effort has been carried out for years to assess the detrimental effects of farming systems and to develop abatement methods to be implemented however despite major advancements many fundamental issues are beyond the scope of existing legislation the main objective of nutritive is to develop a decisionmaking tool dss decision support system able to define the most efficient and sustainable in its three pillars environmental economic and social manure management strategies for a given livestock farm limiting manure air emissions as well as soil and water contaminants this will allow for the formulation of technical guidelines and recommendations that will support policy makers with enhanced knowledge to establish requirements for future european policies to fulfill this objective the project is divided into six work packages wp wp1 uptodate inventory wp2 novel management strategiestechnologies investigation wp3 modelling and lca and wp4 guidelines formulation wp5 communication dissemination and exploitation wp6 managementnutritive anticipates a wide spread of the project outcomes with the synthesis of the consortium as a baseline 22 partners 4 chinese from 8 different countries across europe covering 6 climatic regions 2 chinese ones representing the whole supply chain experts from animal feed to soil application
cavityintegrated electrooptics measuring converting and manipulating microwaves with light

electrooptic technologies have emerged as one of the leading platforms in both classical and quantum communication landscapes the advent of circuit quantum electrodynamics cqed based on lowloss josephson junction circuits has led to spectacular scientific breakthroughs in quantum science and technology in recent years these breakthroughs have been translated into commercial quantum computing efforts worldwide targeting a market with an estimated value of 1 billion euro despite these achievements there are fundamental limitations to quantum technologies based solely on microwaves operating in a millikelvin environment the space required for wiring and electronics as well as the associated heat loads are barriers for scaling up the quantum processors to the size needed to address societal challenges electrooptic interconnects capable of coherently distributing and transferring quantum information from superconducting processors to a room temperature environment would address this challenge such devices would enable quantum processors to be scaled up in a modular fashion which will be key to realizing complex and capable quantum machines that remain controllable and errorcorrectable moreover these microwaveoptical interfaces would also form the basis for efficient laserdriven microwave technologies relevant to sensing applications such as microwave astronomy or robust and lownoise microwave amplification in cielo we aim to lay the foundation for laserbased manipulation of microwave fields using cavity electrooptics enabling amplification quantumlimited optical detection interconversion qubit readout laser cooling and masing in stark contrast to the commonly used electrical techniques we will leverage a combination of unique expertise in integrated photonics advanced materials and superconducting qubits to realize cavity electrooptic devices operating in the quantum regime
increasing biomass conversion efficiency to carbonnegative sustainable biofuels by combination of thermal and bioelectrochemical processes

netfuels develops a novel pathway to produce carbonnegative biofuels from low value biogenic residues such as digestate calamity wood pruning through a combination of thermochemical conversion separation of hydrogen from the syngas oxyfuel combustion of the tail gas bioelectrochemical conversion of co2 into methane and carbon sequestration in the biochar the process will also generate as an additional product a biofuel intermediary high quality pyrolysis oil which has proven conversion route into dropin fuels the project will take the integrated process to trl 5 providing a platform in terms of technical feasibility economic performance and environmental and social sustainability for further demonstration and validation projects in doing so it brings together a consortium of internationally recognized experts in biomass thermochemical conversion bioreactors design environmental sustainability and life cycle analysis dynamic modelling biochar utilisation economic analysis and business case development and dedicated outreach public engagement and social sustainability analysis the netfuels system will be able to deliver 25 mtoe of advanced biofuels in 2030 7 share of the transport fuel consumption if exploiting between one third and one fourth of the total pool of available feedstock listed in part a of annex ix in europe in correspondence of such objective netfuels will ensure 110 mt of co2 of net negative emission
integrating ai in stroke neurorehabilitation

health services are increasingly moving towards a treatment continuum aligned with the patient journey this transition will critically depend on the successful deployment of trustworthy aienhanced technologies that are accurate secure and trusted the aisn project will develop and validate operating procedures and guidelines for integrating ai in a healthcare continuum focussing on poststroke rehabilitation aisn delivers a representative ai health platform built from integrating validated platforms for data acquisition and access clinical interpretation wholebrain simulation clinically validated intervention delivery and optimization and modelbased prediction the aisn integrated platform will be validated in the clinical context of rehabilitation in the outpatient and athome phase and facilitate a concrete assessment of the fundamental ways in which aienhanced clinical decisionsupport will change the care pathway and the formulation of novel ai compatible treatment guidelines aisn ensures an ethical approach by developing legal and ethical guidelines for the robust fair and trustworthy deployment of ai in health and validating acceptance and transparency of its solutions building on the aisn platform the project will test current standard operating procedures for integrating ai in health care and formulate and validate new ones where needed the aisn guidelines and procedures will emphasize the evidence base and safety of clinical interventions transparency prognostics at varying timescales personalization of interventions access to diseasespecific information by clinicians patients and their carers and assure that the potential of ai is fully developed in the service of valuebased medicine satisfying standards of security and safety we will go beyond currently available guidelines and frameworks by emphasizing explainability ai tools with evolving performance and the dynamic interaction between users and algorithms