Dragon09/odtu_chatbot huggingface dataset:
validating ai in classifying cancer in realtime surgery

building on breakthrough research in the ai analysis of fluorescence and perfusion in cancer tissues this project clinically validates the use of aidriven imaging and decision support in realtime cancer surgery cancer and healthy tissue have radically different local blood perfusion patterns this perfusion can be captured using nearinfrared video after systemic fluorophore indocyanine green injection analysis of the video can digitally identify regions of cancer by tracking the perfusion over the initial seconds after dye administration by comparing the fluorescence signal in these areas with those in adjacent normal tissue within the same endolaparoscopic field of view application of ai methods including computer vision and machine learning techniques has enabled this differential classification to occur in real time so that better individualised surgical decisions can be taken during an operation in this project we build up our existing ai solution research prototype into an operating roomstandard surgical tool and validate its performance reliability usability and acceptance in five leading cancer surgery centres across europe 500 patients the validation studies address a generalisability across clinics b biopsy and tumour identification and c optimised resection of large 3cm rectal polyps a key area of current surgical practice where the biggest clinical challenge ensuring accurate patient selection for curative therapy training and education communication and dissemination will be delivered by ircad europes leading surgical education organisation legal regulatory and liability research coled by ucph cebil centre and psu and usability and acceptance research led by surgical professional organisation eaes will identify and address all obstacles to widespread use of this technology in particular and of realtime ai in the operatingroom in general draft clinical guidelines will be created for future eaes adoption
healthier diets and sustainable food and feed systems through employing microbiomes for soya production and further use

animalbased proteins constitute a significant ingredient in european food systems dependence on animalbased proteins comes with substantial environmental and health impacts hence the transition toward plant proteinbased food systems is now more critical than ever microbiomes4soy is an interdisciplinary and intersectoral project that employs a multiactor approach to ensure that food system actors needs and key components relevant to the food 2030 priorities are addressed microbiomes4soy aims to enable transition pathways by delivering a comprehensive understanding of the microbiomes along the food and feed chains exploiting the microbiomes full potential is essential to ensure sustainable and nutritious food and feed as they are important players throughout the food system ranging from primary production where microbes improve plant growth and health to food production based on microbial processes and ultimately linking to the interactions between animalhuman microbiomes and host health microbiomes4soy focuses on the soya bean model system an important proteinrich crop the project will develop secondgeneration microbiome applications that sustain crop productivity and improve soya bean seeds nutritional value and safety under different environmental conditions microbiomes4soy will test the effect of dietary intervention based on soya beanderived protein on the human gut microbiome and health and elaborate microbiomeinformed dietary recommendations the project will also employ microbiomebased solutions to develop novel aquafeeds and establish their effects on the fish gut microbiome and healthmicrobiomes4soy consortium comprises 18 partners from ten countries contributing complementary expertise on soil plant human and animal microbiomes bioinformatics modelling crop production aquaculture foodfeed production food systems mapping and scientific communication
the first comprehensive atlas of the milky way

the milky way is the cosmic environment in which the solar system the earth and life as we know it came into being it is also the veil through which we peer into the extragalactic universe its dust obscures our view of the formation of the cosmos its magnetic fields distort the observations of natures most powerful particle accelerators its structure and metabolism determine the great diversity of observed star and planetary systems including our own due to a lack of distance information currently most information about the structure of the milky way is twodimensional while threedimensional information is needed for a breakthrough in galactic cartography and the science it enables we will create the first comprehensive threedimensional atlas of all the physical components of the milky way our atlas will be selfconsistent between component maps quantify their remaining uncertainties and be the most detailed to date thanks to the dramatic progress in observations at all wavelengths and in algorithmic methods based on information field theory in recent years now is the right time to do this our teams combined expertise in galactic astrophysics algorithms observations milky way surveys and information field theory with its application to galactic tomography puts us in a unique position to generate the first comprehensive milky way atlas we will apply this atlas to a number of pressing questions in cosmology cosmic ray and interstellar medium research and transfer the used tomography technologies into other areas like medical imaging earth monitoring and industrial data analysis
autonomous robotics and digital twin to improve water network performances

our project aims to revolutionize the water industry through the development and commercialization of an innovative robotic inspection system our robotic inspection system offers a comprehensive set of functionalities that enable water utilities to gain deep insights into the condition of their water pipelines with the ability to autonomously navigate inside the pipeline our system conducts detailed assessments of the structural integrity identifies leaks and analyses the quality of the drinking water by developing the digital twin of the water networks our technology empowers water utilities to make informed decisions and take proactive measures to ensure the reliability efficiency and safety of their water networksat the core of our business model is robotics as a service raas which offers a flexible and costeffective solution for water utilities instead of incurring substantial upfront costs water utilities can access our cuttingedge technology on a subscription basis this model eliminates the financial barriers to entry and allows utilities to benefit from the latest advancements in robotic inspection without compromising their budgetary constraints with a strong focus on sustainability our robotic inspection system aligns with several sustainable development goals sdgs including sdg 6 clean water and sanitation and sdg 9 industry innovation and infrastructure during 20252029 our robotic inspection system will preserve 143 million cubic metres of drinking water these savings correspond to the annual consumption of 26 million eu citizens this greatly aligns with global efforts for sustainable water management and environmental preservation
airbrayton cycle concentrated solar power future plants via redox oxidesbased structured thermochemical heat exchangersthermal boosters

abraytcspfuture sets forth an innovative carbonneutral way for implementing into future airoperated csp plants the inherently much more efficient airbrayton gas turbine power generation cycles in order to achieve higher solartoelectricity efficiencies vital for competitiveness of csp and nonreachable by either pvs or molten salts and thermal oils significantly increasing in parallel the plants storage capability both these functionalities will be made possible by developing and demonstrating the integrated operation of a firstofitskind compact dualbed thermochemical reactorheat exchanger design comprised of nonmoving flowthrough porous ceramic structures honeycombs or foams based on earthabundant inexpensive nontoxic oxide materials capable of performing simultaneously the followingtransferring heat from a nonpressurized air stream to a pressurized one while operating simultaneously as a thermal booster raising the temperature of the pressurized stream to levels required for gas turbine airbrayton cyclesincreasing significantly the volumetric solar energy storage density of such airoperated csp plants by rendering their current sensibleonly regenerative storage systems to hybrid sensiblethermochemical storage ones within the same storage volumeboth these functionalities will be materialized by exploiting reversible reductionoxidation reactions of such oxides in direct contact with air accompanied by significant endothermicexothermic heat effects the first one in particular will be achieved by performing the reduction of these oxides with solarheated air streams under atmospheric pressure but their exothermic oxidation with pressurized air streams the proposed technology is set forth by an interdisciplinary partnership spanning the entire csp value chain comprised of leading research centers universities innovative smes and large enterprises including ancillary services providers and technology endusers
efficacy and safety of a newly registered artemisininbased combination pyronaridineartesunate pyramax for the treatment of uncomplicated malaria in african pregnant women extended

pyrapregextended aims to complete pyrapreg project pactr 202011812241529 that determines efficacy and safety of pyronaridineartesunate pa pyramax a newly registered artemisininbased combination to treat uncomplicated malaria in african pregnant women and to provide the necessary information to include this treatment in guidelines for management of malaria during pregnancy the work includes a one year followup of children born to women included in the trial and pharmacokinetic pk substudy in addition this project comprises an extensive capacity building component including the training of phd students pyrapreg activities started 1 march 2019 and were expected to be completed 28 february 2024 intense site preparations were completed but just before start of recruitment covid19 pandemic started and significantly delayed trial implementation participant recruitment started early 2021 and was completed in 2023 with last delivery expected in q3 2023 final 1year visit of children born to women included in the trial will occur mid2024 furthermore sample analysis for qc data cleaning and statistical analysis takes another 6 months to completion allowing final report submission 2 months later feb 2025 pk component was delayed due to late initiation of recruitment for the pk cohorts of patients last patient recruitment in the pk cohort is ongoing and pk sampling will finish q3 2023 participants follow up continues until all women delivered and all babies have reached the age of 1 year pk bioanalysis is expected to be finished by february 2024 pk data cleaning and merging with clinical efficacy and toxicity data followed by population pk and pharmacodynamic modelling activities will then be initiated which will take around 9 months leading up to a pk report by february 2025 phds encountered delays students could not travel for training and data collection for their studies was delayed and will be completed in pyrypregextended
exploring natural immunity in retinal neovascular disease

agerelated macular degeneration amd is the leading cause of irreversible blindness in the world the number of people with amd has reached 196 million with 1 in 10 people over 55 years already showing early signs of the condition 70 of those who progress to latestage disease will develop neovascular nvamd due to uncontrolled growth of blood vessels behind the retina in fact aberrant growth of retinal or choroidal vasculature is a hallmark of diabetic retinopathy and nvamd collectively these are the most common causes of central vision loss globally identification of new biological processes that regulate neovascularization are urgently needed to open new therapeutic options for patients this is a challenge but with recent longitudinal studies showing unequivocally that current goldstandard care has a therapeutic ceiling it presents a critical unmet clinical need i have recently discovered that natural killer cells nks are found in neovascular lesions in human amd and our mouse model data suggests that these innate lymphoid cells ilcs play a role in inhibiting pathology using scrnasequencing i discovered a defined subset of nks in neovascular lesions in a model of resolving nvamd i now hypothesize that in contrast to expectations these ilcs play a critical role in remodelling neovascular lesions limiting pathology as opposed to exacerbating it nk cells are completely unstudied in the retina here i propose that manipulating nk cells may represent a novel therapeutic strategy for the prevention and treatment of neovascular eye disease objectives 1 examine nk cell function in models of retinal neovascular disease 2 profile nk cells in amd pathology in a human study 3 develop microfluidic neovascular retinaonachip model to examine nk cell mechanismofaction 4 determine if nk cell therapy can ameliorate neovascular eye disease goal to harness the power of nk cell activity to treat neovascular eye diseases
upgrading business potential of enzybiotx

since the discovery of penicillin people were living in justified confidence that available antibiotics can cure any bacterial infections emerging antibiotic resistance was usually overcome by treatment with new generation of antibiotics but during last decades bacteria are clearly winning this race overuse of antibiotics particularly in agriculture and lack of investments in discovery of new antibiotics lead us to situation when increasing number of bacterial infections cannot be cured due to lack of effective remedy antibiotic resistance surveillance revealed rising antibiotic resistance around the world who predicts that if no appropriate actions are taken by 2050 antibiotic resistance will be responsible even for 10 mln deaths every year to address this urgent medical need new antibiotics and alternative methods of combating antibiotic resistant bacteria are needed one of the new approaches which is getting more and more interests among academic and industrial research groups are enzybiotics bacteriolytic enzymes that in a very effective and selective way eliminate bacteria including antibiotic resistant strains at the same time displaying very low resistance prevalence enzybiotx provides a deeptech platform for tailor madeenzybiotics targeting specific bacteria our company has developed the platform for design and generation of new enzybiotcs to target pathogenic bacteria of interest as an answer to the need of alternative antimicrobials development the company in collaboration with potential clients is able to prepare tailormade enzybiotics which target pathogens and in collaboration with the client perform all tests needed to adjust enzymes properties to be able to introduce them to the final products the founders of the company are experienced academics who have gathered unique expertise in isolation and characterisation of new enzybiotics
machinery rooms of the mediterranean 1800present images and visual archives of movement and acceleration

the aim of medmach is to write a new history of the mediterranean after 1800 through images of movement infrastructures and machineries of acceleration such as airports train stations motorway bridges industrial ports and enginedriven ships these sites are often overlooked in overarching narratives of the region the mediterranean after 1800 typically appears either in decline or romanticized therefore this machinery room of modernity has never been at the center of attention however these sites of movement are connected to all the aspects which make the mediterranean an emotive politically relevant place today migration colonization and decolonization the relation between europe and the islamic world environmental and economic crisis conceptualizing the modern and contemporary mediterranean through its machinery rooms of movement will slice through the divisions of fragmented national histories and provide a basis for the differentiated yet connective history that is needed to face those challenges this history will be based on images and image archives in the modern period after 1800 images are increasingly made for distribution and circulation they are entangled with the ambivalent modern notions of movement and acceleration they are also ideal carriers of transnational and transregional knowledge medmach will advance epistemic knowledge about the modern and contemporary mediterranean moreover it will work with a visual approach to establish a new systemic historical understanding which is urgently needed in current debates on travel transit migration environment and cultural encounter key words mediterranean visual archives infrastructure mobility acceleration migration modernity circulation
polarized 3d endoscopy

the proliferation of artificial intelligence ai has led to a major advancement in many fields it has enabled achieving nonprecedent achievements such as humanlevel image recognition intelligible language translation and accurate medical diagnosis the main research goal of the pis ercstg spade project is to use tools for data modelling to improve our understanding and usage of deep learning dl and thus enhance its performance in medical problems and computational imaging 14 one of the fields that could greatly benefit from such progress is sensitive medical treatment using aibased medical devices such devices can initially assist the physicians with a more accurate diagnosis and potentially save lives as such technology matures the information provided to the physicians will be richer thus leading to more accurate diagnoses to the cases at hand such advancement will allow high quality and efficient treatment to a much wider public the scope of this poc is to apply intelligent optical imaging methods developed in the spade project specifically for introducing reliable 3d and polarization information to medical imaging devices
how perceptual history shapes vision neural mechanisms and predictive properties

what we see at any given time is not solely determined by the information currently reaching our eyes the visual system is indeed thought to leverage on perceptual history ie the stimuli saw in the recent past to contextualise and optimise perception the incorporation of past stimulus information into perceptual processing has important consequences shaping how we perceive external objects and events according to the context in which they are embedded in namely perceptual history can bias perception in an attractive way making a stimulus to appear more similar to its preceding one than it actually is the nature and mechanisms of attractive perceptual history effects are however unclear due in part to seemingly conflicting findings suggesting either that the bias is perceptual in nature occurring in lowlevel sensory areas or a cognitive effect based on decisionmaking with previs i will provide a new perspective on these effects proposing and testing a novel hypothesis namely instead of being uniquely based on past information as currently assumed attractive perceptual history biases may entail an active predictive mechanism in this scenario the attractive bias would arise from a prediction based on past stimuli rather than the past stimuli themselves performed by highlevel brain areas and affect the processing of sensory information in lowerlevel areas in previs i will use psychophysical techniques coupled with electroencephalography eeg and functional magnetic resonance imaging fmri to test this hypothesis and assess the neural signature and correlates of perceptual history and predictive processes the innovative perspective of previs represents an important step forward from the current state of the art and the project has the potential to clarify the nature of perceptual history effects and the mechanisms involved in this fundamental process shaping perception
understanding emergent physical properties of chromatin using synthetic nuclei

the main aim of this proposal is to resolve how the physics of molecularscale activities result in the emergent material properties of chromatin and how those contribute to chromatin organization and function mounting evidence suggests that the material properties of chromatin regulate essential nuclear processes chromatin has been studied with two disconnected approaches pure in vitro studies perfectly suited for careful biophysical measurements on single dna molecules but lacking the complexity of a cell or intact cell measurements with limited access to measure material properties and smallscale chromatin dynamics the physical properties of chromatin however are emergent and result from the molecular activities that are in turn regulated by those properties as a consequence it is crucial to establish new experimental assays that connect these two scales and levels of complexity here i will bridge the gap in scales and biochemistry between pure in vitro assays and measurements in intact cells by reconstituting chromatin processes in xenopus laevis egg extracts across scales i will combine quantitative microscopy optical tweezer measurements and theory to biophysically characterize the selforganization of proteindna cocondensation and loop extrusion and single chromatin molecules of increasing complexity to bridge the microscopic and the macroscopic scales i will assemble synthetic nuclei made of preengineered dna sequences which allows for exquisite control of dna length amount and chromatin activities in combination with microrheology micropipette aspiration and magnetic tweezers i will unravel how the collective behavior of chromatin activities gives rise to the emergence of largescale material properties of chromatin this project will provide a physical description of the material state of chromatin across scales and contribute to reveal the basic physical principles that govern nuclear organization and function
perovskite ferroelectric materials for sustainable energy technologies

many governments are working towards decarbonising their economies with the eu having set netzero targets to be reached by 2050 at the moment however still about 70 of all the worlds power comes from burning fossil fuels ie coal oil gas it is clear that in order for these goals to be feasible and economically viable the way we generate and use energy needs to change drastically one way of addressing this challenge is research into novel more advanced classes of quantum materials where broadly speaking new structural and electronic properties can start to emerge here ferroelectrics are a leading candidate for achieving highperformance energy technologies offset aims to explore the potential of ferroelectric materials for future energy applications by focusing on one specific material class nitride perovskites while the properties of many nitride perovskite candidates have already been studied computationally experimental realisations have been lacking hindering potential applications in order to achieve these goals offset aims to synthesise a number of structures using molecularbeam epitaxy this will be combined with advanced characterisation techniques including cryogenic and structural measurements as well as piezoresponse atomicforce and transmission electron microscopy in order to assess their quality and quantify the piezoelectric ferroelectric response at a later stage offset also aims to explore potential technological applications including uses as memories photovoltaics andor thermoelectrics this will be achieved via an advanced nanofabrication programme making use of the cleanroom facilities available at both project partners with these efforts offset expects to acquire fundamental knowledge on the viability and feasibility of nitride perovskites for use in future energy technologies