Dragon09/odtu_chatbot huggingface dataset:
delineation of experiencedependent astrocyteneuron cognitive dynamics

in the brain cells called astrocytes are as abundant as neurons but are much less understood over the recent years we have begun to appreciate how closely astrocytes support the development and function of synapses the proposed substrate of memory one emerging function of astrocytes is their direct involvement in learning and longterm memory indeed astrocytic activity is affected in major brain disorders that affect memory such as alzheimers disease the overarching aim of this fellowship is to study how astrocyteneuron coordinated activity relates to learning and memory i propose that astrocyteneuron activity dynamics are shaped by learning over days to support memory formationto test this hypothesis i will use stateoftheart microscopy and genetically encoded fluorescent proteins both available in the host laboratory to record the activity of large numbers of neurons and astrocytes while mice are trained in a perceptual learning task over days in this way i will be able to see how neurons and astrocytes change their activity in response to learning i will then manipulate the activity of astrocytes using clever genetic tools and light while the mice are being trained and monitor the effects of this manipulation on the activity of neurons and memory performance this step will allow me to establish causal links between astrocyte activity and memory finally i will use modern statistical learning techniques to explore the contribution of astrocytes and astrocyteneuron interactions to the computational capacity of the brain this proposal capitalizes on my strong expertise in rodent behaviour and data analysis my knowledge and strong interest on how experience shapes brain activity and the established microscopy and genetic techniques in the host laboratory overall this project will allow me to acquire new skills and knowledge in microscopy and astrocyte biology and generate testable hypotheses for my future research
mobility justice for all framing safer healthier and happier streets

just streets is the project proposal from a team of 30 partners from 17 countries including 12 cities representing more than 45m citizens it aims to transform cities carcentered mobility narratives that take for granted that streets are for motorized traffic only promoting walking cycling and other active modes of mobility just streets will be reshaping street infrastructure and changing individual mobility behavior in 12 cities while proactively sharing the generated howtodoit knowledge with hundreds of cities for rapid replication across europe in close collaboration with citizens policy makers experts and interest groups the project will not only develop a new vision of spatial justice where streets become public space for all but equally important find ways to rapidly implement changes a strong focus is on displaying how necessary transformations in the face of climate change can and must successfully improve social justice accessibility inclusivity and security along the way putting marginalized social groups the most vulnerable mobility users as well as those citizens at the core of just streets that have been previously underrepresented in mobility infrastructure decisionmaking will allow the project to create highly valuable knowhow critical in creating better more just and sustainable cities for all citizensthe unique composition of the just street consortium is critical in making sure this knowledge is not only created but subsequently shared with as many urban decision makers as possible from cities across europe who have the means to initiate transformation in their cities toplevel research and organizations with vast experience in the fields of mobility urban planning climate change and social transformation are collaborating with the communication and dissemination expert partners who have established channels to reach and interact with tens of thousands urban decisionmakers that will shape the future of cities
botanical concrete new green material for artificial reef

tourism recreation fishing marine aquaculture and many other economic activities depend on the diverse marine ecosystems globally however a combination of factors such as global warming ocean acidification and increment of cyclones in recent years have led to the aggravating degradation of natural reefs one of the most varied marine ecosystems on earth artificial reefs ar are widely used for habitat restoration ecological development and coastline protection concrete is the most successful ar material but it generates substantial co2 emissions has high contamination and has low bioreceptivity botanical concrete developed by author during phd study is based on the concept of a circular economy with 100 responsible use of waste materials and its carbon negative and nontoxic characteristics provide exciting potential in building the green infrastructure in ocean this research aims to enhance the durability bioreceptivity and versatility of woodwastebased botanical concrete to create a green route for the design of the new generation of multifunctional ecofriendly ar for coastal protection and coral restoration based on nutrition water quality and settlement substrate test in marine environment lablevel the raw materials are selected followed by formation design through advanced simulation computed tomography scanning and experiments on durability and mechanical performance and life cycle assessment the prototype of ar will be tailored to achieve optimal density for easy installation high resilience in storms superior capability for coral larval settlement and biodiversity the results will revolutionize the way in which ars are made and boost the efficient use of recycled resources and alleviate climate change by moving into a clean circular blue economy the project will contribute to the eus sustainable blue economy strategies including decarbonization circular economy biodiversity climate adaptation and sustainable food
sharp regularity bounds of maximal functions

in 1997 juha kinnunen proved that maximal operators satisfy a sobolev bound if the sobolev exponent p is strictly larger than 1 his article initiated the study of regularity of maximal functions a field which has attracted several dozens of authors to this day geometric techniques have recently lead to a series of breakthrough endpoint regularity bounds for maximal operators in higher dimensions this project pursues the novel strategy of combining these new geometric tools with already established extremization techniques in order to solve a wide range of open questions in the fieldthe goals of the project are organized around two themes gradient bounds and sharp constants the main goal from the first theme is to prove that the variation of the noncentered hardylittlewood maximal function can be controlled by the variation of the function in all dimensions this is the endpoint p1 of juha kinnunens original bound and is one of the main long standing open questions in the field this project also aims to prove this variation bound for further maximal operators along with the operator continuity of their gradient and bounds for higher derivativesthe main goal from the second theme is to prove that the centered hardylittlewood maximal operator in one dimension does not increase the variation of a function this bound would be sharp because examples show that in general maximal operators do not strictly decrease the variation of a function this project further aims to prove this sharp bound for convolution type maximal operators and to find the sharp constant in the variation bound for the dyadic maximal operator in all dimensions
european partnership for a sustainable future of food systems

the vision of futurefoods is to collectively achieve environmentallyfriendly socially secure fair and economically viable healthy and safe food systems fs for europe futurefoods gather 87 partners from 22 eu member states 6 associated countries and 1 third country futurefoods includes public and private actors policy makers foundations locally subnationally nationally euwidelyall these futurefoods partners are fully aligned on the vision for the partnership and the methodology for its implementation in line with sdg17 and eu green deal components this vision has been broken down into general go specific so and operational oo objectives applying across the 4 ri areas and 4 transversal activities identified by the futurefoods consortium in its stable draft strategic research and innovation agenda sria which constitutes the strategic backbone of the project the four go cover go1 functioning of fs go2 system approaches go3 inclusive government go4 cocreation cases these go have then been translated into so prioritised in line with the timescale and resources of the partnership so1 change the way we eat so2 change the way we process and supply food so3 change the way we connect with fss and so4 change the way we govern fsin addition 6 interconnected oo have been set oo1 pooling ri resources and programming oo2 operational fs observatory oo3 active fs knowledge hub of fs labs oo4 functioning knowledge sharing and scaling mechanisms oo5 revisiting the sria oo6 promoting supporting widening gathering fs various communities the objectives implemented in the 8 wps of futurefoods will exert impact directly or indirectly in most of the destinations of horizon europes cluster 6 20232024 work programme and particularly for the topic destination fair healthy and environmentfriendly fs from primary production to consumption echoing to the main eu and world fs policies strategies
protactus from longterm consequences of road crashes

battling serious injuries and longterm consequences in road traffic remains one important issue in the overall goal of resilient future road transport vision zero challenges of increasing personal transport in urban areas coupled with autonomous vehicles and shuttles new mobility devices and the overall need to ensure the safety of vulnerable road users as well as all types of vehicle occupants require innovative approachesprotactus project aims at protecting all road user groups from serious injury and longterm physical cognitive and mental health consequences of road crashes through innovatively interlinked research action between medical and engineering methods protactus enables therefore the development of efficient resilient inclusive and effective countermeasures as well as postcrash action for all relevant road transport meansprotactus will work on the following goals and challengesmedical data correlation standardization and classification of longterm physical cognitive and mental health consequences of road crashesrobust and reliable assessment tools and methods allowing for effective countermeasure development for all road usersreduction of longterm consequences and related social cost of road crash related injuries for all road usersthe protactus solutions will influence new standards in respect of extending current injury coding system with relevant longterm aspects for physical cognitive and mental health related injury allowing new physical as well as virtual safety assessment procedures and adaption of rules and regulations to be implemented finally scientifically wellfounded suggestion for future implementation into policy regulatory and standardization guidelines for an inclusive safety improvement approach for in as well as postcrash will be provided
advancing crossborder coaching and economic support for specialised services

eicaccess mission is to enable eic awardees and seal of excellence holders to access specialised services offered through the eic service catalogue by offering financial support to partially cover the services price and facilitating the delivery of tailored assistance to address the unique scaling challenges of deep tech european innovators an initial survey will allow to assess the alignment of the pool of services available in the eic catalogue with the needs of the eic community members their availability and accessibility and provide actionable information and recommendations to assure a complete coverage of key categories of needsthrough a permanent public open call for applications up to 180 beneficiaries will be selected to access three categories of service packs from the eic catalogue to answer their specific needs and matchmaking them with eic ecosystem partnership service providers the selection process will be aimed to efficiently assign and distribute the financial support to the selected eic community members as lump sums eicaccess will carefully monitor the service delivery and assess results and impacts for the eic community members through detailed statistics and analytic dashboards making sure that stringent quality standards are respected and reflected through an overall high satisfaction rate and the emergence of success stories to be promoted in the yearly uptake and impact report and more generally through online channels and social mediathe initiative will contribute in close synergy with the eic and the contractor implementing the call for ecosystem partners to making the eic ecosystem partnership stronger by facilitating the service delivery with the financial support providing insights about the service offer availability and impacts and engaging the community in a peer learning and coconstruction process to fill in the gaps and fully cover the needs of the eic community members
the pressure effects on magnetic properties of an ideal quasi2d planar antiferromagnet bani2v2o8 at the base and finite temperatures

the pressure attracts noticeable attention in the field of condensed matter physics because it can modify magnetic and electronic properties of the compounds the external pressure can induce both structural and magnetic phase transitions giving experimental access to novel magnetic phenomena this makes pressure a promising tool to customize the magnetic properties of solidstate compounds both at the base and finite temperatures however no comprehensive study has been done so far on the investigation of the pressure effects on overall magnetic properties such as hamiltonian magnetic structure and critical behavior of a model magnetic system i address these issues in the pressmag project which explores the pressure effects on magnetic properties of an ideal quasi2d planar antiferromagnet bani2v2o8 at the base and finite temperatures first i will solve the magnetic structure and hamiltonian of bani2v2o8 under applied pressures and then will study the critical behavior of bani2v2o8 under applied pressures using both neutron and xray scattering techniques in particular the pressmag project will study for the first time the pressure effects on the berezinskiikosterlitzthousless phenomena whose signatures were recently discovered in bani2v2o8 finally the smallangleneutronscattering technique will be used to image the berezinskiikosterlitzthousless vortices in vacuum and under applied pressure
a novel role for pge2 signalling in promoting aged neuromuscular junctions reinnervation and counteracting sarcopenia

aging is characterised by a progressive decline in muscle mass and force potentially resulting in the insurgence of sarcopenia sarcopenic patients are at an increased risk of falls and fractures with a concordant decrease in mobility and personal independence evidence suggests that key determinants of sarcopenia insurgence are muscle denervation failure of its reinnervation and degeneration of neuromuscular junctions nmj representing the connection between the nerve and the muscle and essential for muscle function this msca project will inform our understanding on the interplay between prostaglandin signalling and the nmj in the onset and treatment of sarcopenia prostaglandin e2 pge2 stimulates tissue regeneration its levels are reduced in aged human and mice skeletal muscles due to increased activity of its degrading enzyme 15 prostaglandin dehydrogenase 15pgdh inhibition of 15pgdh in aged rodents restores pge2 concentrations to youthful levels increasing muscle mass strength and endurance however the mechanisms underlying how 15pgdhpge2 modulation exerts these effects are not well understood here i will show how pge2 impacts nmj integrity in mice establishing if restoration of its signalling restores nmjs innervation progressively lost in aging my final aim is to determine whether boosting pge2 levels via 15pgdh inhibition represents a viable therapeutic strategy to treat sarcopenia to confirm the relevance of the dysregulated 15pgdhpge2 axis in determining nmj alterations in humans i will perform single nuclei rnaseq and spatial proteomics codex on muscle samples of young and aged healthy presarcopenic and sarcopenic individuals i will integrate the molecular data with invivo muscle morphology and function 1 to reveal whether 15pgdh expression activity and localization is different in sarcopenic muscle and correlates with any invivo parameter and 2 to generate a macrotomicro atlas of human aging and sarcopenia
evaluation of healthysustainable food proteins

access to healthy and sustainable foods is an existential priority as recognized by the un who and eu replacing animalbasedproteins with their plantbased counterparts is expected to be a major step forward due to a 28 fold depending onthe species increase in protein efficiency in order to speed up this protein transition methods need to become available toallow for highthroughput evaluation of protein ingredients in terms of technical functionality that rules food properties andphysiological functionality that ultimately decides on effects taking place in the bodythe evaluator project focusses on plant protein properties in colloidal emulsion systems for which a tailormademicrofluidic platform will be developed to dynamically assess technical emulsion stability and digestibility for this wechoose to work with pea and bean proteins that are readily available at low cost within the eu the microfluidic platformallows realtime investigation at micro and nanometre levels the scales at which basic food structure elements are formedand degraded and within very short time spans through highspeed recording therewith closely mimicking the actualprocess conditionsevaluator will not only lead to the design of healthier and greener food systems but also supply a versatile microfluidicplatform that allows design from first principles ie the actual protein properties as they are relevant for food production anddigestion this brings food design that currently revolves around trial and error into a completely different realm and evenmore importantly establishes the currently missing link between technological functionality and digestionthe key for success is the combination of my background in microfluidic design and digestion that of the hosts in emulsionswur the netherlands and the secondment inrae france in advanced digestive systems which allows me to cover allaspects of the evaluator project in a groundbreaking way
transforming co2 into addedvalue construction products

the european green deal sets ambitious targets to ghg emission reductions for the process industry that can only partly be reached by the transition to renewable energy residual hardtoabate co2 emissions from industrial processes such as steel and cement production will need to be captured and wherever possible processed and recycled into new products the shift towards low carbon processes may disrupt existing industrial symbiosis pathways if no alternative linkages are developed this may lead to increasing emissions in downstream sectors the transitions in steel and energy production lead to dwindling supplies of low carbon resources for cement production such as blast furnace slag and coal fly ash the core concept of carbon4minerals addresses the simultaneous use of co2 from industrial flue gases with current and future waste streams to unlock a vast stock of resources for innovative low carbon binders and construction materials 80135 lower co2emissions than reference a total of 8 industrial pilots will be built and operated across the process value chain from co2 capture to cement production and low carbon construction products this crosssectorial innovation has the potential to reduce european co2 emissions by 46 mty equal to 10 of the eu process industry emissions while safeguarding the competitiveness of the european industry a consortium of technology providers producers and research partners will develop test and demonstrate the processes technical environmental and economic feasibility will be validated by an integrated assessment in combination with the development of a service life test package tailored to these new products colearning modules are developed to support industrial implementation and market introduction
rna topology of test samples and single extracellular vesicles how cells package rna messages to communicate rnatop

in rnatop i will investigate the precise locations and quantity of rna associated with extracellular vesicles eg evrna topology to achieve this goal i will setup innovative liposomebased synthetic vesicle models herafter referred to as test samples resembling evs with a known rna topology i will use these test samples to create workflows for super resolution microscopy srm and spectral flow cytometry sfcm to study rna topology these workflows will be extrapolated to ev samples to define evrna topology of single evs for the first time the research will be conducted in the amsterdam umc under the supervision of dr rienk nieuwland nieuwland and his team have the knowledge experience and technical infrastructure to perform srm and sfcm to study evs therefore rnatop will allow me to deepen my knowledge on evs and gain skills to perform srm and sfcm conversely i will bring my expertise in liquid biopsies and rna obtained during my phd in pangaea oncology in barcelona h2020mscaitn i will carry out a secondment in the lab of dr zoltn varga research center for natural sciences in budapest an expert in the field of creating test samples to get handson training at the end of the project i will join exometry supervised by dr edwin van der pol cso for a 6month nonacademic placement to 1 develop an analysis software to process rna topology data and 2 gain commercialization skills the unique interdisciplinary and intersectoral combination of the participating organizations and myself unites all the expertise and infrastructure required to reach the objectives of rnatop