Dragon09/odtu_chatbot huggingface dataset:
methods for stroke monitoring and diagnosing based on bcg

clinical monitoring of the heart health of stroke patients is usually done by electrocardiogram ecg recording a noninvasive method that requires electrodes in contact with the patients skin to obtain the signal however since specialists are required to place the electrodes its use is restrictive contactless alternatives for study of heart conditions in less restrictive way have been investigated for decadesthis project aims to develop novel noninvasive methods for detecting cardiac and noncardiac disease in stroke patients using the ballistocardiogram bcg signal allowing for patient monitoring without transfer to clinical settings the objective of the project is to answer important questions in current research in biomedical engineering such as whether the resolution of a bcg is sufficient for the detection of cardiac conditions and whether it can become the preferred method for monitoring heart health from hometo achieve this objective the project proposes the development of a portable prototype for the acquisition of bcg signals as well as the development of novel algorithms that allow for the detection and classification of cardiac arrhythmias and episodes of sleep apnea from these signals the project will be based on three different stages design and implementation of the prototype obtaining new diagnostic support algorithms based on ballistocardiogram signals and the connection strategy at the prototype to deliver the information to the specialist doctorsthis is a multidisciplinary project that combines expertise in bioengineering health sciences electronics and telecommunications this proposal also aims to transfer knowledge to the host institution and provide training for the candidate in advanced techniques the results have the potential to significantly improve the capacity of home health monitoring and the application of ehealth knowledge this project is aligned with the eu strategy for the protection of human health
determining the mechanisms behind goblet cell dysfunction

goblet cells are specialized epithelial cells that secrete mucus and antimicrobial proteins which together form the gut mucus barrier the mucus barrier protects the host from bacterial invasion and subsequent activation of an inflammatory response while also providing food for the microbiome dysfunction of goblet cells and high penetrability of the mucus barrier are hallmarks of inflammatory bowel diseases ibd while the reasons for goblet cell dysfunction are unclear it is thought that inflammation host genetics specifically mutations in autophagy genes and environmental factors can affect their function yet despite their importance the basic biology of goblet cells is not understood as they are part of a heterogeneous tissue i developed a new mouse model that allows isolation of ribosomes specifically from goblet cells in vivo thus revealing the translational response of goblet cells to various conditions in preliminary studies we found that altering the autophagy process in vivo led to modification of the colonic mucus barrier alteration of the microbiome and resistance to colitis we also found that antibiotic treatment an environmental factor which increases the risk for ibd altered the mucus barrier and instigates gut inflammation in mice our goal is to mechanistically determine how inflammation autophagy and antibiotics affect goblet cell function during health and ibd we will 1 define goblet cell function during ibd development in vivo and test if goblet cells fail to regain proper function during remission leading to relapse we will also 2 use a novel mouse model of augmented autophagy to determine the role of autophagy in preserving goblet cell function during ibd lastly 3 we will use germfree mice to reveal the microbiomedependent and independent effects of antibiotics on goblet cell function and ibd our study will provide new understanding of goblet cell biology and may lead to new therapeutics which target goblet cells
largescale and wideband brain dynamics mediating memory consolidation in the freely moving rat

dementia is a major healthcare challenge worldwide due to its high incidence and its strong impact on the life quality of patients and on society as a whole development of treatments for the mitigation of memory impairment in patients with dementia has proven very challenging partly due to our limited understanding of the underlying mechanisms of memory consolidation memory consolidation is mediated by communication between largescale networks in the brain particularly the hippocampal formation and neocortical circuits coordinated by synchronous oscillatory dynamics as shown in both humans and animal models during the resting state in humans this coordination is associated with complex restingstate network rsn dynamics that are reflected in spatiotemporal patterns of infraslow 05hz brain activity however the link between rsns dynamics and wellunderstood neuronal dynamics underlying memory consolidation in animal models remains a major knowledge gap due to technical limitations wideband ephys has a unique potential to close this gap by mapping extracellular potentials with high spatiotemporal resolution in a wide frequency band enabling inference of rsn dynamics across brainwide networks in freely moving rats using customized graphenebased neural probes in combination with neuropixel 20 probes fiberphotometry and optogenetics i aim to investigate the mechanisms underlying memory consolidation with an unprecedented level of detail extending the current knowledge on the functional role of rsns and local slow oscillations in the rat could lead to the development of novel treatments for dementia which will be explored in collaboration with the private sector during this project the interdisciplinary approach presented in this proposal will complement my expertise in neurotechnology with more advanced skills in fundamental neuroscience enhancing my career prospects in the field of translational neuroscience
enzymatic cascade biotransformations in digitally manufactured continuousflow bioreactors

within industrial biotechnology applied biocatalysis is poised to transform drug discovery and development by pharmaceutical industry enzymes as catalysts allow for synthetic chemists to generate molecular complexity avoiding costly and timeconsuming protection and deprotection steps however the high cost associated to their use especially if a cofactor is required the low substrate tolerance and productivity and the difficulties for scaleup strongly limit the industrial uptake of these processes the combination of enzyme immobilisation and continuous flow cf offers an opportunity to overcome these limitations enzymatic performance and recyclability can be dramatically improved by immobilisation and generic problems such as low productivity and substrate inhibition effect can be solved using cf during the last years enzymes have been most commonly immobilised in packed bed reactors however the very low flow rates required to achieve full conversion decrease the mixing and make the system look closer to a batch reaction with its generic problems here we aim to address these limitations through the design and manufacture of 3d printed 3dp reactors that combine optimised mixing at low flow rates with tailored surface modification techniques with ionic liquids ils for stable biocatalyst preparation and higher number of active sites 3dp facilitates the generation of complex geometries in a variety of materials based on ils tailored to optimise enzyme stability the aim of this proposal is to integrate chemical engineering 3dp continuous flow reactors and biocatalysis stable and recyclable immobilised enzymes to develop more efficient biotransformations in flow easy and effective immobilisation of enzymes and significantly promote sustainable development of ib it will have a direct impact in the eu from an environmental economic and social perspective lowering drug prices facilitating distributed production and reducing waste
elucidating the role of microbial metabolites in stabilising and protecting the leaf microbiome

the oomycete pathogen albugo laibachii plays an important role in structuring the phyllosphere microbiome of arabidopsis thaliana plantassociated microbial communities are known to provide protection against pathogens at least in part through the production of specialised metabolites that suppress the activity of pathogenderived proteases thanks to the advances in nextgeneration sequencing and nontargeted mass spectrometry we have gained new insights into the community and metabolic dynamics of the plant microbiota nevertheless we are just at the beginning of fully capturing the sheer number and complexity of the community members and the countless still unknown metabolites they produce the molecular mechanisms underlying microbemicrobe and plantmicrobe interactions remain thereby mainly elusive so far only a few metabolites have been identified as plantprotecting agents but the full protective potential of a microbiome through the synergistic action of multiple microbial compounds remains largely hidden to shed light on the bioactive potential of the exometabolome of the plant microbiome as a whole i will apply a multimodal functional metabolomics strategy that provides information on the potential protease inhibitory activity of all the compounds secreted by a predefined synthetic microbial community our focus will be on the stabilisation of the microbial community composition mediated by protease inhibition and the related plantbeneficial activities through synergistic interactions with other defence strategies connecting those activities to individual metabolites will allow us to better understand the beneficial effects of the community as a whole and how dysbiosis may contribute to pathogenesis it will also allow for the rational design of nextgeneration microbiome derived biocontrol agents which are urgently needed for a more sustainable agriculture
circular construction finance

the circofin project brings together 4 cities and regions to transition to a circular economy in the construction and buildings sector munich copenhagen scotland and lisbon will prepare investmentready circular construction hubs cch and showcase how they transform local and regional markets for secondary building components and materials cch cover physical material banks and digital infrastructure to provide the resource basis for the eu taxonomy requirements for construction to date cch have not successfully scaledup across europe the project will demonstrate that cchs can become bankable projects at scale and provide lucrative investment opportunities for financiers the showcases develop sound technical business and financial plans of more than 80 m total investment volumecircofin streamlines a common project development assistance pda methodology for cch used and validated by the showcases the methodology results in a cch toolbox which consists of customizable components for all project development stages from prefeasibility to due diligence and bankability appraisal it covers all elements of cch physical design digital infrastructure logistics business models operation models and financial models the results will be published as a cch cookbook with concrete facts and figures ready for widespread replication by other cities and regions replication and rollout aim to trigger uptake in 30 other cities and regions from the ccri circular cities declaration and the mission cities of the 100 climateneutral and smart cities mission investors and eu financial initiatives will gain expertise in advising cch projects via robust technical and operational insights and learn how to review associated risks to make better investment decisions on circular economy projects standardization will on cen and iso as well as policy recommendations improve regulation to enable business and investment cases for cch market uptake in europe
integrated assessment and advanced characterisation of neuronanotoxicity

the incidental accidental or intentional release of manufactured nanomaterials into the environment and its exposure to humans is inevitable due to the exponential growth in invention production and use of them it can have a huge impact in our health specially in the most sensible and exposed human body organs such us lungs stomach and brain icare aim to to develop a resilient and adaptive set of advanced imaging technologies to quantify physicalchemistry properties for anmc in complex matrices the main objective will focus on a integrated model system to characterize and predict the impact of nanomaterials on brain health to prevent the toxicity nanomaterials the project makes accessible for industry a set of techniques and methodologies to evaluate changes in morphology chemical composition and reactivity of nanomaterials when exposed to complex homogenous matrices mimicking environmental and biological exposure with a particular emphasis on highresolution imaging methodologiesto achieve this goal the project the project brings together in the consortium 11 partners from different backgrounds such as rtos smes industries and universities from different eu and noneu countries and coming from different fields like nanotech toxicology advanced materials advanced imaging during the 48 months long of the project the consortium will work on the development of different activities to achieve the following results 1new imaging methods achieving new high resolution methodologies and new super resolution imaging techniques 2development of toxicology testing protocols and addressing current gaps in nanotoxicology 3development of tools and methods bringing the gap in vitro and in vivo testing 4efficiency of materials and product development 5delivery of reliable data and improved data reporting and finally development of harmonised standardised test methods that can be used in regulatory frameworks
convection and transfers in a textured partiallymolten planet from the magma ocean stage to presentday solidstate convection

how and when plate tectonics pt developed on earth and why the earth is currently the only rocky planet of the solar system with pt are two of the main enigmas of earth and planetary sciences the evolution of a planet is conditioned by heat transfer in its most viscous envelope the mantle this heat transfer is mostly due to convection and strongly depends on the convective patterns which in turn depends critically on mantle rheology however the link between rock rheology at small time and lengthscales and mantle effective rheology at the longlarge scales of mantle convection is still missing i propose that it resides in the mesoscale structure of the mantle and lithosphere that are acquired through convective motions and partial melting hence deciphering the evolution of the earth or any other planet requires describing and understanding the interplay between texture ie material multiscale organization rheology twophase flow and convection our team recently showed that aqueous nanoparticle colloids fluids commonly used by soft matter physicists can reproduce planetary phenomena such as onesided subduction and the twophase flow dynamics of midocean ridges building on this softplanet will combine convection in these soft materials with stateoftheart visualization techniques to relate surface morphology including faults wrinkle ridges and volcanism lithospheric structure and internal flow patterns and characterize the development of texture and rheology from the nanoscale to the macroscale of convection softplanet will map the different regimes of convection that can develop and will derive a physical understanding of each this new physical framework together with geomorphology observations will be used to decipher the current state of venus and the divergent evolution of venus mars and the earth
targeting cancer with erv vaccines

inprother ipt is developing a unique immunotherapy breakimmune that effectively targets endogenous retroviruses hervs to treat cancer hervs are not expressed in normal tissues but are expressed in several major cancers such as breast 88 prostate 90 ovarian 90 and pancreatic 80 thus hervs can be a potential target for the immune system to destroy tumor cells ipt technology relies on the engineering of hervk antigens to be used as effective cancer vaccines the administration of breakimmune the mutated hervk in ad19mva viral vectors induces both strong antibody and tcell immune responses able to destroy cancer cells in multiple cancer types our first product is ipt001 a first in class vaccine against solid cancers in combination with checkpoint inhibitors
support stakeholders fora on geothermal systems

in order to decarbonise the power heating and transport sectors and reach a climate neutrality by 2050 europe needs a wide range of renewable technologies including geothermal systems geothermal will be a key energy source in the european decarbonized energy mix indeed geothermal is a unique energy source that can provide a significant share of electricity heating and cooling thermal storage and minerals such as lithium in 2022 and beyond it is a source of energy which is renewable local and continuously available as it is not dependent on climate conditions europe has pioneered the exploitation of geothermal resources for over a century and the eu still maintains a leading role due to research innovation and the development of new technologies allowing the production of geothermal power as well as heating and cooling everywherein this proposal the project geothermfora aims at facilitating research and innovation ri activities in geothermal systems by supporting the workresearch development and innovation rdi are needed to develop renewable technologies accompanied by market uptake measures major investments in geothermal research and innovation are necessary to develop and deploy the next generation of geothermal technologies and answering the challenges for the transformation of our energy system towards a decarbonisation of our economy research development and innovation rdi are needed to develop renewable technologies accompanied by market uptake measures major investments in geothermal research and innovation are necessary to develop and deploy the next generation of geothermal technologies and to answer the challenges for the transformation of our energy system towards a decarbonisation of our economy
biobased surfactants from renewable waste streams for the circular economy

with climate and environmental concerns topping the global agenda industries across all sectors are under tremendous pressure to rapidly change their existing fossilbased practices by shifting toward cleaner greener more sustainable in one word future fit solutions in business and production while maintaining economic competitiveness internationally surfactants 17 million tyear market globally are omnipresent in key industrial segments detergents personal care coatings agrochemicals pharmaceuticals and companies are actively looking to shift toward biobased alternatives while maintaining product performance surprisingly the valorization of renewable waste streams occurring in large quantities for making novel surfactants has not been adequately exploited so far the reason for this is the lack of fundamentally new technologies in this areawith the credo superior performance and clean conscience puresurf introduces groundbreaking manufacturing concepts to produce novel highperformance biobased surfactants from currently underutilized renewable waste streams in erc poc pure project novel green surfactants were obtained by green and scalable synthetic pathways resulting in 2 patent applications building on this the puresurf validation activities will include upscale at least one gemini anionic and one zwitterionic surfactant structures to 1 kg to validate their properties using clean starting materialsupscale to 5 kg trl56 at least one selected example using industrial waste streamsdetermine properties ecotoxicity biodegradability also anaerobic as well as performance in industrial applicationscritically compare to existing surfactants establish a business case and prepare an investor ready technologythe puresurf team consisting of leading experts in green chemistry engineering and business with strong industrial network aims to establish a spinoff company and become frontrunner in biobased surfactants
green and digital continuousflow pharmaceutical manufacturing

greening and digitalizing pharmaceutical manufacturing is one of the grand challenges of europes pharmaindustry it offers a significant opportunity to boost productivity improve competitiveness and reduce the industry large environmental footprint current progress is impaired by shortage of trained engineers and scientists who can design green and digital pharmaceutical processesthis msca doctoral network will focus on addressing these skills gaps delivering a cohort of highlyskilled and trained phd graduates that will lead the green and digital transformation of the pharmaceutical manufacturing both in academic and industrial environments the consortium brings together 7 universities 1 research center and additional 11 associated members from academia and industry this will address urgent topics in continuous green manufacturing and develop greener routes to prepare pharmaceutical products promoting the adoption of novel technologies flow synthesis instead batch methods heterogeneous nano and biocatalysis in lieu of homogeneous catalysts renewable carbon sources novel purification methods digitalization tools for sustainable manufacturingspecific phd topics for 10 esrs have been outlined the research and training programme will equip the esrs with key scientific and transferable skills such as ipr entrepreneurship data and innovation management the consortium strong track record in the management of interdisciplinary research and training will ensure effective and timely training of the nextgeneration leaders of europes pharmaindustries the exposure to academic and industry sectors will also provide the researchers with unparalleled career opportunities
a novel role of small rna pathways in regulating dna replication in polyploid cells

small rnamediated gene regulation and dna replication are fundamental genomeregulatory pathways essential for cellular life organismal development and disease prevention while small rna pathways are known to sequencespecifically regulate dna copy number in some unicellular animals such connections have yet to be found in multicellular animals with this project i will investigate and mechanistically characterize such a potential connection in the drosophila animal model system piwiinteracting rnas pirnas a class of animal small rnas safeguard the germline genome against repetitive dna proliferation by guiding repressive heterochromatin formation at target loci in drosophila melanogaster ovarian nurse cells heterochromatic pericentromeric dna repeats undergo selective local suppression of dna replication thus lowering their relative copy number interestingly abundant pirnas able to target to these underreplicated regions have been found yet the potential functional interactions between small rna genome defense and dna replication remain unexplored with this project i will bridge this gap by investigating the role of satellite pirnas in drosophila melanogaster focusing on the interplay between regulated dna replication and small rna genome defense two interconnected hypotheses will be examined 1 pirnadirected heterochromatin formation regulates centromeric dna copy number and 2 pirnaregulated heterochromatin sinks alter epigenetic inheritance to do so i will apply advanced sequencing and imagingbased methods for dna copy number quantification and leverage the powerful drosophila genetics to uncover underlying molecular mechanismsin sum my investigation of small rnabased regulation of dna replication holds the promise to reveal a new paradigm in animal genome regulation and to provide deeper insights into the mechanisms regulating genome stability and the role of pirnas in maintaining it