Dragon09/odtu_chatbot huggingface dataset:
customised membranes for green and resilient industries

increased energy and resource efficiency in industrial sectors is paramount to build a resilient and sustainable future in this context the cumeri project will develop and demonstrate at trl7 advanced and customised membrane separation systems in two key industries in the steel sector where h2 will be recovered and co2 captured in one comprehensive system and in the og industry where a twostep liquid filtration system will enable base oil and additives recovery from used lubricant oilto reach these goals cumeri gathers 16 partners 7 rtos and 9 companies including 4 smes and will elaborate in 36 months three impactful membrane technologies 1 enhanced biobased and recyclable polymer membranes for co2 permeation 2 stable and selective sicsicn membranes for h2 recovery for a better h2 valorisation in the steel sector 3 grafted porous ceramic membranes for waste oil purification and additives recovery by ultrafiltration and liquidliquid membrane contactors all membrane systems will unlock greater energy efficiency and decreased emissions in their respective sectors high separation performances together with increased chemical mechanical and thermal stability will be demonstrated moreover reusage and recycling of membranes will be validated beyond these demonstrations the project will generate novel insights on membrane separation including a variety of flexible solutions to help industry the scientific community and policy makers accelerate the rollout of separation technologies to maximise the impact of cumeri other promising separations will be screened and the transferability of results to other industries refinery pharmaceuticals etc will be ensuredthrough its activities cumeri will pave the way to decreased emissions in the industry to the greater valorisation of valuable chemicals and to more energyefficient processes promoting resilient and circular industrial value chains
does exposure to artificial light at night impacts immunity and microbiome in natural populations of an amphibian

the constant increase of urbanization and human activities worldwide is exposing animals and human to a multitude of stressful stimuli that disrupt physiological functions in organisms a major source of pollution nowadays that affect 99 of the european territory and thus almost every organism in europe is light pollution or alan artificial light at night recent studies suggest that the immune function could be strongly disrupted by exposure to alan but these results mostly comes from experimental studies conducted in laboratory conditions and thus not realistic of real conditions of exposure to the light pollution considering the current major biodiversity loss crisis especially in amphibian taxa it is crucial to know if the ability of wild organisms to mount appropriated immune respones and control infections is affected by this anthropic source of pollution within an ecoimmunological and one health framework this project has thus been designed to characterize for the first time and totally in natura the effects of alan on immunity microbiome composition and infectious phenotype of a common nocturnal vertebrate the common toad bufo bufo using 30 wild populations of common toads living on a natural gradient of exposure to alan in a french region this project will characterizei how exposure to alan impact toads immune phenotype using multiple measures to precisely characterize the different immune components that may be differently affected ii how exposure to alan impacts toads microbiome composition at the two main interfaces of skin and intestinal mucosa characterizing bacterial and eukaryotic communities iii if toads infectious phenotype is dependent of alan exposure immune responses and microbiome composition focussing on pathogens identified as a threat for amphibians in france
coordination mechanism for cohorts and trials

the overall goal of comect is to coordinate activities across europes strategic adaptive platform trials apts and cohort studies cs on infectious diseases ids with epidemic or pandemic potential by overseeing and facilitating dialogue sharing of good practices promoting collaboration and coordination across studies and providing updated information on initiatives and innovation in id clinical researchcomect will build on and strengthen existing networks and infrastructure these include eufunded coordination mechanisms and networks namely the trial coordination board tcb joint access advisory mechanism jaam the cohort coordination board ccb and the ecraid coordinating comittee comect will develop a visible welldefined coordination mechanism to highlight europes capacity and competence as an attractive base for clinical researchcomect will deliver1 an expanded combined european coordination mechanism that will work on harmonizing research initiatives exchange of good practices and stakeholder engagement across id clinical studies in outbreaks and during interepidemic phases2 a strengthened jaam to support coordination through independent scientific assessment of compoundsvaccines and recommendations for apts to evaluate the new compound in new or adapted platform trials3 the mapping of stakeholders and their respective activities relevant to apts and cs4 a harmonised approach crossstudy identification assessment and reuse of participantlevel data from european apts and cs5 coherent communications and stakeholder engagement across all activities6 a sustainability plan for the continuation of activities beyond the funding periodcomect will quickly adapt coordination efforts to a changing research landscape and to new id threats comect will operate in close collaboration with other emergency preparedness mechanisms such as hera ema glopidr and the european pandemic preparedness partnership
european women and religious dissent the advent of modernity and the democratic public sphere

at a time when fundamentalisms and populisms threaten basic human rights it is extremely important to investigate the roots of european values such as egalitarianism and democracy in order to contribute to popular and scholarly debates on these subjects in an informed way addressing the historical relationship between religion and ideas of modernity the euword project aims to provide a better understanding of laypersons contribution women and men to the development of the enlightenment when democratic concepts gradually emerged as basic rights it addresses particularly the history of a religious minority in seventeenthcentury europe the dutch collegiant movement and pursues a specific goal to reveal how the practice of enlightened concepts and the participation of women in freediscussion meetings cocreated the development of enlightened values the theory did not cause the practice both were mutually implicated in development to pursue this goal the euword project blends the methodologies of social history gender history history of ideas and political philosophy and has two objectives 1 an updated account of the collegiants practices the presence of women among their ranks and their european network regarding their meetings as interconfessional free associations that fostered the birth of an early public sphere 2 an examination of the interrelations between the collegiants practices and the concepts they advocated focusing on their debates on gender equality and womens right to free speech and revealing how these debates were related to similar ones throughout europe due to its originality and interdisciplinarity the euword project will have a major impact on several fields of study as well as on the general public indeed research outcomes will be disseminated through academic eg a digital map of the collegiants network and two scholarly articles and public eg a twitter account and blog entries activities
innovative multifunctional retrofitting systems for heritage structures

65 of the built cultural heritage is structurally deficient due to ageing lack of maintenance and exposure to natural and manmade hazards this figure is expected to increase given the effects of climate change structural retrofitting is vital for the preservation of our cultural heritage and the safeguarding of its social and economic value traditional repair systems have shown inadequate longterm performance with 20 of the repairs failing only after 5 years thus requiring everincreasing rehabilitation and maintenance costs this calls for more durable retrofitting solutions capable to guarantee structural performance and provide actionable information on their damage state before safety is jeopardisedaesthesis will leverage stateoftheart retrofitting systems for heritage structures using textiles embedded in inorganic matrices and transform them for the first time into smart systems that can feel the damage and repair themselves both textiles and matrices will be engineered through the inclusion of sustainable electrically conductive materials and industrial byproducts to achieve desired electromechanical properties and stimulate inherent autogenous healing mechanisms aesthesis will unlock the full potential of selfsensing and selfhealing materials and develop an innovative allinone retrofitting solution with tailored functionalities to meet the specific performance criteria of heritage structures thus enabling a paradigm shift from corrective to proactive retrofitting the work will be underpinned by a systematic multiscale multiphysics approach and culminate in the field demonstration of the proposed technology aesthesiss breakthrough will reinforce the european identity by providing safer and resilient heritage structures and will increase europes competitiveness in the retrofitting sector by providing fundamental knowhow on the design of multifunctional systems and practical design tools to promote their faster uptake
extending the perovskiteinspired mixedmetal chalcohalide alloy space for solar cells

renewable energies play a central role in the decarbonisation of the energy sector and mitigating manmade climate change photovoltaic pv technology provides a clean safe and affordable renewable source of energy new photovoltaic materials with high power conversion efficiencies are needed to meet the european green deals 2050 targets and to ensure the largescale deployment of solar cells an encouraging material class are perovskites but as they suffer from toxicity and stability problems this impedes their commercial viability one promising alternative are mixedmetal chalcohalides pimmchs which have the potential to overcome these known problems with perovskites and still exhibit good optoelectronic properties thus making them of interest for pv applications however this promising class of materials remains widely unexplored the aim of this project extpimmch is to expand the material space of pimmch compounds and our understanding of this material class i will explore i binary and ii ternary pimmch alloys in order to identify promising pimmch alloys which are suitable for indoor and outdoor pv applications for this purpose i will use a combination of density functional theory dft and machine learning to accelerate the material exploration finally i will identify a few dozen promising pimmch alloys for indoor andor outdoor pv applications to facilitate further experimental research also i will study iii the influence of defects such as vacancies interstitials and antisites on pimmch materials using dft which can be used to determine the defect toleranceintolerance of pimmch materials a profound understanding of defects in pimmch materials is essential because they could have a significant effect on the performance of pv applications overall extpimmch will facilitate the development of efficient stable and nontoxic pscs thus accelerating largescale commercial adoption of pscs
scaling up capacity to support conduct of clinical trials in the east african community

the east african community eac has experienced significant increase in volume and complexity of clinical research driven by epidemics of emerging and remerging infectious diseases such as hiv ebola and covid19 requiring expertise in scientific and ethical review and conduct of research and a robust and pragmatic research regulatory framework the overall goal is to strengthen scientific and ethics capacity in eac for high quality research review conduct and oversight at international standards the specific objectives are 1 to train nrra personnel rec members researchers and clinicians on scientific and ethics review and conduct of research with emerging and complex study designs including adaptive platform trials 2 to train nrra personnel and rec members on oversight monitoring and pharmacovigilance of clinical trials and 3 to train nrra personnel rec and research administrators on personal effectiveness and leadership skills pels to manage the increasingly complex research processes methods we will implement this project within a consortium of research scientists from the six partner states collaborating with the eu partner with the east african health research commission as the strong nucleus for coordination and dissemination of results the project will be hosted at the infectious diseases institute idi where within a previous nih funded program 5g11 tw01130901 we built capacity for rec members researchers and rec administrators for 7 recs in uganda with significant improvement in knowledge pels quality and turnaround time of research review and researcher satisfaction this proposal fits within the scope of ghedctp320220105 call whose aim is to strengthen clinical research capacity and improve efficiency of the regulatory environment for effective development delivery and uptake of new and improved safe health technologies and rapid response to emerging epidemics guaranteeing international standards and attainment of sdg3
quantitative ultrasound stochastic tomography revolutionizing breast cancer diagnosis and screening with supercomputingbased radiationfree imaging

ultrasound imaging can be deeply enhanced by means of algorithms developed in the field of geophysical imaging such algorithms based upon adjointstate modelling and iterative optimization provide quantitative images of human tissue with very high resolution at present time such images can only be attained by means of highperformance computing and using specific ultrasound data acquisition devices when combined hardware and software have a huge impact potential for softtissue imaging such as in breast cancer imaging nevertheless and as is customary in medical imaging the obtained images only provide with the mean or most likely values of tissue at each pixel being uncertainty quantification an extremely expensive process typically deemed as unfeasible for practical purposes a revolutionary development in adjointbased ultrasound imaging allows us to potentially obtain images of uncertainties at the cost of a single meanvalue image such development will be the basis of transformative implications in terms of confidenceestimates for diagnosis we aim at disrupting the breast cancer screening paradigm by means of a safe radiationfree accurate quantitative and reliable uncertaintyaware novel breast imaging modalitywithin qustom we will investigate the fundamental science behind adjointbased uncertainty imaging and establish its potential suitability for breast cancer diagnosis the feasibility of the technology as a diagnosis tool relies on 1 adapting the data acquisition hardware for optimal resolution 2 implementing the algorithms in highperformance computers in order to obtain a short timetosolution and 3 feasibility analysis by expert radiologists in comparison with the stateoftheart in breast imagingthis proposal covers the three aspects and opens the possibility of applying similar principles in other imaging fields both in medicine and elsewhere
predicting apoptosis engagement downstream of caspases in vivo

epithelial cell death is widespread during development and tissue homeostasis while the core pathway of apoptosis is well known we lack predictive power to understand when and where a specific cell will die in a tissue yet this should have important consequences for clone selection and tissue homeostasis as exemplified by the process of cell competition this context dependent cell elimination is essential for tissue homeostasis and tumour progression but we know very little about its prevalence during normal development recent works have characterised multiple nonapoptotic functions of effector caspases and a high frequency of cells undergoing transient caspase activation without death yet what distinguishes a dying from a surviving cell downstream of effector caspase activation is completely unknown using quantitative live imaging of effector caspase sensors and caspase activity tuning by optogenetics in the drosophila pupal notum a single layer epithelium we found that cells engage in apoptosis at very variable levels of effector caspase activity this suggested that the engagement in apoptosis can be developmentally modulated downstream of the most terminal caspase activation and that a completely new layer of regulation of cell death could have important physiological roles here we propose to combine quantitative live imaging multivariate model supervised machine learning and quantitative perturbations through optogenetics to define parameters predictive of the engagement in apoptosis downstream of caspase activation we will then use spatial omics combined with an optogenetic based screening to identify new factors modulating the sensitivity to caspases eventually we will unravel the physiological functions of caspase sensitivity modulation by defining a new paradigm of physiological cell competition and clone selection and characterising its impact on tissue morphogenesis and oncogenic cell elimination
eegbased diagnosis support solution edison to help close the epilepsy diagnosis gap in low and middleincome countries lmics by combining low capex and aiguided capture with telemedicine

about 40m people in low and middleincome countries lmic suffer from epilepsyrelated seizures but not all are diagnosed and treated due to the lack of electroencephalogram eeg devices and neurologists in these regionsbraincapture bc is developing an eegbased diagnosis service braincap for epilepsy and other neurological disorders that fits lmic needs since it is affordable uses mobile phone infrastructure and does not need an eeg expert onsite for data capture due to an aibased quality control qc algorithm data is analysed by remotely placed neurologists who provide a diagnosis and treatment plan via the braincap appcloudour field trials revealed that there is a clinical need for braincap now we will finish the product design optimize the qc algorithm and extend clinical validation to multiple sites to convince kols in several primary markets the eic investment will be key to create eeg market in lmics leveraging a significant business opportunity for bc
chelomics application of multiomics approaches to provide a holistic understanding of siderophore mediated hostpathogen interactions and new diagnostic options for aquaculture fish infections

outbreaks of bacterial diseases pose a persistent challenge to fish farming around the world causing significant economic loss to improve efficiency safety and sustainability of aquaculture new health monitoring and rapid disease diagnostics approaches are required here we propose an ambitious multidisciplinary project that implements modern multiomics tools in particular metabolomics and metagenomics to provide a holistic understanding of hostpathogen interactions in farmed fish in the context of three major bacterial diseases vibriosis photobacteriosis and furunculosis this project will focus specifically on the metabolome of siderophores iron chelating microbial metabolites that are key virulence factors during infection and their use as biomarkers for early disease diagnostics in nature microorganisms exist in diverse communities and therefore infections can be caused by a combination of species yet the involvement of cospecies in disease progression is poorly understood and represents a great diagnostic challenge i have gained extensive skills in metabolomics through my phd in australia and postdoctoral experience in germany this project will enable me to go one step further i will use different bioinformatic tools as well as imaging analytical chemistry maldiims approaches to integrate metabolomics and microbiome data and answer important ecological questions in aquaculture i am highly motivated to take on this new challenge and acquire new scientific and transferable skills which will strengthen my profile as an independent researcher and increase my opportunities for a permanent position after the fellowship
beyond the breadline charitable food provision and survival strategies of the urban poor in a comparative perspective

food charities have become essential pillars in assisting the urban poor offering a crucial buffer between food insecurity and hunger their significance particularly after the great recession is underscored by two pivotal shifts one towards the sustainable utilisation of food surplus and waste reduction and the other reflecting societal changes with diminishing welfare benefit provision while considerable research addresses food insecurity and support the literature lacks a robust framework to understand and compare charitable food provision cfp across countries and cities despite the almost universal occurrence of such transitions existing studies have not yet contextualised this phenomenon within the diverse arrangements of welfare and civil society regimes and the influence of transitions in agrifood sustainability on cfp accordingly this proposal aims to1 use event sequence analysis to chart the historical trajectory of cfp in italy japan and the netherlands examining the emergence and consolidation of professionalised cfp sectors in diverse institutional settings2 adopt mixedmethods social network analysis to examine current cfp dynamics in palermo kyoto and rotterdam focusing on providers interrelationships operational modes and their ties with both state and nonstate authorities3 harness urban ethnography to investigate the interdependence between food insecurity and support to understand how cfp becomes part of poor peoples survival strategiesadditionally it introduces an innovative tool tailored for city workshops to facilitate realtime data collection on cfp urban dynamics hence it combines the findings obtained by crafting an overarching framework to extend cfp comparison to other countries and cities the research will create new knowledge across urban sustainability organisation food and social policy studies offering an innovative comparative insight into food support and insecurity
extremescale urban mobility data analytics as a service

emeraldss vision is to design develop and create an urban dataoriented mobility analytics as a service maaas toolset consisting of the socalled emeralds services compiled in a proofofconcept prototype capable of exploiting the untapped potential of extreme urban mobility data the toolset will enable the stakeholders of the urban mobility ecosystem to collect and manage ubiquitous spatiotemporal data of highvolume highvelocity and of highvariety analyse them both in online and offline settings import them to realtime responsive aiml algorithms and visualize results in interactive dashboards whilst implementing privacy preservation techniques at all data modalities and at all levels of its architecture the toolset will offer advanced capabilities in data mining searching and processing of large amounts and varieties of urban mobility data and its efficiency will be assessed validated and demonstrated in three trl5 pilot use cases by following a codevelopment approach with mobility and city stakeholders to improve decision making in urban smart city environments and deployedshowcased in two early adopters datadriven trl6 applications by integrating the new services to existing systems to improve commercial offerings