Dragon09/odtu_chatbot huggingface dataset:
designing democracy on mars and earth exploring citizens democratic preferences in a deliberative and cocreative design

ddme sets up a bottomup cocreative and deliberative design to obtain a deeper understanding of citizens democratic preferences in two western germany and united states and one nonwestern country india democratic preferences contain procedural preferences for different governance modes such as participatory delegative consensual or majoritarian forms of democratic governance as well as preferences for democratic goals and values such as equality or social justice based on input and feedback from democratic theorists ddme explores how citizens imagine ideal democracy on mars and mend real democracy ie how they would reform the political systems they live in on earth when they had the chance to deliberate ie to weigh reasons regarding the pros and cons of the various conceptions and schemes of democracy in a dialogical setting with their fellow citizens the deliberative field experiments will comprise 600900 representative or maximally diverse citizens and will be run on a hybrid platform combining synchronous and asynchronous modes of interaction ddme analyses which factors drive different democratic preferences of citizens in the three different countries and which principles and arguments play a role in the opinion and preference formation of citizens democratic preferences with a specific eye on opinion and preference change the project is the first to delegate democratic designing to citizens adopting a systematic and global approach where citizens together with democratic theorists think through advanced theoretical inputs and think creatively about optimal democratic designs
heterogeneous integration of imprecise memory devices to enable learning from a very small volume of noisy data

the artificial intelligence community inspired by the tremendous progress made in neuroscience has recently proposed powerful algorithms to enable effective realtime decision making based on a limited volume of noisy sensory data however implementing such algorithms in lowpower devices remains a challenge due to the energy inefficiency that comes from separating logic and memory in current electronic systems for the past 10 years research groups have been developing alternative electronic components and systems such as brain inspired computing architectures and novel resistive memory technologies to address this design bottleneck the critical feature for these new technologies to perform at their best is a very highdensity reliable nonvolatile memory with infinite endurance this ideal memory does not exist today and it is unlikely it will ever exist this project takes inspiration from the insects nervous system the general aim of diverse is to enable learning from a very limited volume of noisy data based on imperfect limited density low endurance resistive memories unlike digital systems insects are not very good at performing precise calculations but they excel at making extremely energyefficient real time decisions by combining sensory data recorded in noisy environments i thus propose to take inspiration from the wellstudied crickets nervous system and to use my experience and skills in resistive memories to develop a new technology that expresses robust cognitive behaviour while interacting with the environment this crossdisciplinary work will lead to the fabrication of an innovative hardwaresoftware platform with extremely high power efficiency and robust cognitive computing capabilities this new technology will open new perspectives in dynamically developing areas including service and consumer robotics implantable medical diagnostic microchips and wearable electronics
wireless networks within nextgeneration computing systems

computing systems are ubiquitous in our daily life and have transformed the way we learn work or communicate with each other to the point that progress is intimately tied to the improvements brought by new generations of the processors that lie at the heart of these systems a common trait of current computing systems is that their internal data communication has become a fundamental bottleneck the anticipated death of moores law has forced computer scientists and architects to find new ways to build faster processors which include massive parallelization specialized accelerator design and disruptive technologies such as quantum computing these trends cause an exponential increase in the volume and variability of data transfers within computing systems rendering traditional interconnects insufficient and threatening to halt progress unless fast and versatile communication alternatives are developedin this context the winc project envisions a revolution in computer architecture enabled by the integration of wireless networks within computing systems the main hypothesis is that wireless terahertz technology will lead to at least a tenfold improvement in the speed efficiency and scalability of both nonquantum and quantum systems with a crosscutting approach winc aims to validate the hypothesis by i revealing the fundamental limits of wireless communications within computing packages ii developing antennas and protocols that operate close to those limits while complying with the stringent constraints of the scenario and iii developing radically novel architectures that translate the unique benefits of the wireless vision into orderofmagnitude improvements at the system level if successful winc will be the seed of a new generation of nonquantum and quantum systems and foster progress in the computing field for the decades to come
scalable entangledphoton based optical quantum computers

the photon being chargeless and massless is the ideal qubit material since it is the only elementary particle with no decoherence based on over 25 years of research at the center for nanoscience and nanotechnology c2n cnrs and univ of paris saclay we demonstrated the worlds first efficient emission of single photons powered by our unique semiconductorbased technology nature photonics 2016 in just a few years we completed the design and construction of prometheus which integrates all the necessary components to deterministically generate qubits based on single photons prometheus is the main building block for mosaiq our fullstack photonic quantum computing platform integrating all the building blocks from prometheus to the photonic chips efficient detectors and all the software stack including opensource perceval to control and simulate hardware and algorithm layer mosaiq is designed and built to be modular reconfigurable interconnected and therefore scalable
regionalised trajectories and sociopolitical transformations in the late 4th early 3rd millennia bce in mesopotamia

the late 4thearly 3rd millennium bce in mesopotamia featured widespread changes often cited as a period of societal collapse transform will explore the effect of this rapid change through close examination of pottery production at the site of kani shaie in the kurdistan region of iraq kri the key research question driving transform is to what extent are the major societal transformations during this period replicated in the production of pottery at kani shaiepottery production is the realisation of a set of social and technological choices thus sudden changes to it the likes of which are documented during this period at kani shaie are socially and culturally significant thus transform will reconstruct the pottery manufacturing process across this transitional period to investigate the effects of these societal transformations and how the occupants at kani shaie adapted to them this project will transcend traditional approaches by examining the social dimension of pottery production through application of a multidisciplinary methodology which seamlessly integrates archaeology material science geology and anthropological theory the researchers background and methodology uniquely place him to critically examine how localised trajectories underpin larger sociocultural transformations the project will benefit from the researchers cross disciplinary skills combined with unprecedented access to an extensive archaeological dataset and expertise at uc in questioning the effect of the lceba transition at kani shaie transform will produce significant results by highlighting the effect that local communities had upon and how they were affected by supraregional cultural processes this investigation presents an exciting opportunity to examine behavioural transformations when faced with major societal upheavala better understanding of which should give us pause to consider the ramifications of impending transformations facing us today
validation of treatment decision algorithms for childhood tuberculosis at low levels of healthcare in high burden countries effectiveness implementation and integration into policy and practices

childhood tuberculosis tb remains globally underdiagnosed and untreated in 2022 who conditionally recommended the use of treatment decision algorithms tdas to improve the diagnosis of pulmonary tb in children 10 years and called for the external validation of two suggested tdas for children the decidetb project aims to generate evidence for the implementation of a comprehensive tdabased approach for tb in children living in highburden resourcelimited countries at district hospital and primary health centre levels and to facilitate the integration of this evidence into practice and policy as an interdisciplinary consortium of researchers and national tb programs ntps we will conduct a programmatic pilot of whosuggested tdas also integrating specific tdas for children living with hiv andor those malnourished and severity assessment for shorter treatment decision in nonsevere tb disease clinical mentoring tools and a clinical decision support system will be developed district information systems will be strengthened to collect individual data for program monitoring and supervision by ntps and for research the tdabased approach will be tested in a pragmatic stepped wedge clusterrandomized trial including effectiveness implementation sociobehavioural economics and policy research components the diagnostic accuracy of tdas will be assessed in a parallel metaanalysis of children with presumptive tb from recent studies led by consortium members the pragmatic trial and metaanalysis will contribute to external validation of the whosuggested tdas engagement of key stakeholders and decisionmakers throughout the project will support adoption into international and national policies and into clinical practice through validation of tdas widespread policy adoption and translation into clinical practice decidetb will increase access to safe and effective tb management for children thus reduce tb mortality and contribute to sdg3
precarity amongst women migrant nightworkers in ireland

precnights is an ambitious anthropological project on labour migration and precarity contributing with novel theory on differential inclusion of the essential yet invisible women migrant nightworkers wmn in ireland through an innovative interdisciplinary and ethnographic approach the research will impact scholarly debates in migration and will inform key irish and european stakeholders on migrant workers rights to reach these aims precnights objectives are 1 unpack how are wmn expected to perform their gender in nightwork 2 explore factors that affect wmns responses to invisibility and precarity 3 examine how management practices and work culture impact wmns understanding and crafting of their selfpresentations and 4 unpack the structural invisibilisation and precarisation of wmn precnights aims to make visible wmn through intersectional methodology that not only examines precarity migration gender and nightwork but also focuses on how each of these four dimensions magnifies the lived experiences of the others and further through groundbreaking digital and nocturnal ethnography that captures night experiences together these enable an inclusive analysis of the lack of power and privilege and the forms of oppression and inequality faced by wmn precnights thus uniquely contributes to scholarly efforts and policy work dedicated to understanding the contemporary european labour migration regime which produces conditions of marginality in urban settings not just in ireland but also in other eu contexts precnights will be hosted by iss21 university college cork and will progress under dr caitriona ni laoires vital supervision as her background and expertise in qualitative multimodal research and sociospatial dynamics of inclusionexclusion are at precnights core
engineered cartilage from nose for the treatment of osteoarthritis encanto

knee osteoarthritis oa is one of the most common causes of pain and disability affecting over 500 million people worldwide the tremendous socioeconomic burden caused by oa is expected to further increase due to rising life expectancy and obesity current therapeutic approaches are limited to pain management or knee arthroplasty but no diseasemodifying or regenerative treatment is availableencanto will address this major unmet clinical need by clinically introducing a combined atmp for the biological reconstruction of the degenerated joint facet in patellofemoral oa pfoa this tissueengineered cartilage ntec based on autologous nasal chondrocytes and a collagen membrane was previously successfully used for focal cartilage lesions the central part of encanto is an international blinded multicenter prospective randomized controlled phase ii trial to clinically assess the efficacy of ntec for the treatment of pfoa patients samples will be analyzed to retrospectively identify pfoa molecular endotypes and associated biomarker signatures with the most successful clinical outcome after ntec implantation to predictively select responders to therapy to achieve these aims encanto brings together tissue engineers with practice in atmps knee surgery and rehabilitation specialists research institutes experienced in regulatory affairs health economics and atmp development excellent scientists involved in the assessment of oa endotypes and patients representatives smes from the consortium will develop a road map towards commercial exploitation including centralized marketing authorization after demonstrating efficacy for pfoa ntec will be considered for other forms of oa in different joints encanto will thus introduce the first diseasemodifying therapy for cartilage degeneration enable mobility and social gain for a large patient group and play a pivotal role in strengthening europes position in delivering regenerative medicine solutions
enabling efficient computation on fault tolerant quantum computers

our solution is an innovative suite of hardwareagnostic quantum algorithms along with their hardwareaware implementations our solution will consist of a complete multilevel set of techniques that reduce quantum circuits size and improve their fidelity when executed on real quantum hardware we will enable relevant business problems too difficult for conventional computing to be solved several years earlierthe exemplary solution consists of1 application layer with problem reduced classically to the form best suited for qc in case of routing this is parallel tsp reduced for example to max 2sat 2 optimisation layer containing features guaranteeing optimal representation given problem size this includes our decomposition techniques for multicontrol quantum gates 3 implementation layer guaranteeing optimal use of the hardware this includes hardware aware implementation taking into account the topology qubit connectivity and native gate set
governing human rights through partnerships investigating the normative and operational interface of international law and multistakeholder governance

the 2030 agenda for sustainable development and the sustainable development goals hail multistakeholder partnerships msps as key actors in achieving sustainable development msps that bring together states businesses philanthropy and civil society are increasingly in the frontlines of providing public goods that are human rights such as food health education and water in these domains partnerships are spearheading the continued expansion of multistakeholder governance into international law including human rights law this expansion has been taking place without critical appraisal with respect to its effectiveness and consequencesgenesis breaks new ground by exploring the normative and operational implications of this shift both at the systemlevel and at the level of specific global partnering initiatives and individual multistakeholder partnerships genesis investigates the interface of international law and multistakeholder governance in the realisation of human rights it analyses how the paradigms of multilateralism and multistakeholderism diverge or converge as they simultaneously govern the domains of food health education and water through human rights law and multistakeholder partnerships respectivelygenesis has three main objectives that will generate high research and policy gains first genesis will uncover and understand how norms that govern human rights through multistakeholder partnerships are made in the post2015 era in the governance of foodsdg 2 health sdg 3 education sdg 4 and water sdg 6 second genesis will investigate how multistakeholder partnerships impact the way human rights are operationalised third genesis will identify pathways to an effective uptake of human rights legal standards by multistakeholder partnerships in doing so genesis will derive insights on whether and how international law and multistakeholder governance can generate common ground when governing public goods that are human rights
eulac strategic partnership for the implementation of digital dialogues in ri cooperation

spider aims to support the exploitation of the full potential of the newly established bella network and the implementation of the outcomes of eulac dialogues in the context of digitalisation and rispider proposes a multistakeholder approach to enable the development of an eulac strategic partnership spider will engage relevant ri stakeholders from eu and lac more actively and strategically in supporting dialogues and creating a common and orchestrated vision and strategy for the exploitation of the full potential of bella network and the implementation of the outcomes of digital dialogues enhancing eulac cooperation in rispider will adopt a humancentred and participatory approach combined with an inclusive and intersectional perspective to support the development of strategic partnerships to stimulate the use of digital technologies that can benefit from bella and are relevant for eulac ri cooperationat the core of this strategy is the eulac digital dialogues implementation forum dif that is unique of its kind in international cooperation in ri and will serve as a multistakeholder platform to foster dialogues and exchange of best practices to support the implementation of digital dialogues commitments furthermore dif working groups will support the adoption of a humancentred approach to technology development alongside diversity equality and inclusion dei principles coupled with this spider will assess the use of bella and identify pathways for its future exploitation by engaging key actors of the digital ecosystem in project activities moreover spider will implement a twinning programme to foster digital partnerships by connecting eu and lac innovation hubs that can seize the opportunities of bella for digital transformation on top of that a cascade of events including dialogue forum events focus groups call for ideas webinars and workshops demodays and a final conference will support the project actions
inhibitors of ecf transporters as novel antibacterial agents

antimicrobial resistance is a global health threat urgently calling for the development of novel antiinfective strategies we will adopt a multidisciplinary approach to design synthesize and optimize derivatives targeting ecf transporters as antibacterial agents the ecf transporters are transmembrane proteins involved in the uptake of vitamins predominantly in grampositive pathogens eg streptococcus pneumoniae enterococcus faecalis e faecium staphylococcus aureus their inhibition prevents the uptake of vitamins from the environment leading to starvation followed by cell death due to their critical role in the homeostasis of vitamins in bacteria as well as their absence in humans ecf transporters are considered a promising novel antimicrobial target we will thoroughly profile our inhibitors for their in vitro ontarget and antibacterial activities we will on the one hand further validate the cellular target through advanced target engagement studies and attempt to achieve a cocrystal structure using cryoelectron microscopy furthermore evaluation of the inhibitors for their in vitro admet properties and in vivo pharmacokinetic profiles will set the stage for in vivo infection models in mice the extensive data that we will gather will enable us to nominate the most promising compounds for further multiparameter optimization en route to the nomination of a preclinical candidate ultimately this opens access to novel antiinfectives with an unprecedented mode of action
sustainable materials and process for green printed electronics sustainaprint sap

prompted by the dire forecasts for increased resource extraction and waste generation and their detrimental effects on climate and biodiversity a circular economy action plan has been put forth where electronics and electronic equipment have been identified as a priority product group with circularity potential with an annual growth in waste of 2 this group is one of the fastest growing waste streams in the eu while less than 40 of electronic waste is recycled within the eu there is a need to explore new options for electronics that are designed for reuse repair and highquality recycling to address this challenge several factors must be considered such as the industrial end users ieu specifications life cycle analysis lca and the products endoflife eol printed electronics pe is an additive manfucaturing method that can address these challenges and is characterized by its versatility scalability and low material usage thus making it an ideal candidate for a circular production of electronics in general flexible and even stretchable electronics can be obtained with this method by printing conductive and dielectric inks on flexiblestretchable substrates opening new applications in the market however similar to traditional electronic production methods current life cycle for a pe product starts with materials substrate conductive and dielectric materials obtained through mining of raw materials these materials are put into production lines consisting of large volume analogue printing gluing on discrete components and lamination processes the eol are either landfills or incineration which in both cases destroys precious materials thus forcing the use of mined raw materials the main goal of sustainaprint sap is to open new lifecycle routes and to design and implement sustainability into each step of the lifecycle this includes choice of materials their usage their origin their processing assembly and eol