Dragon09/odtu_chatbot huggingface dataset:
horticultural innovations in soilfriendly practices to ensure a sustainable future

europes horticultural production systems face 3 main sustainability problems i continued reliance on peat growing media and drawbacks of current peat alternatives ii inefficient or inappropriate use of agricultural inputs iii suboptimal soil health due to unsustainable management practices the multiactor project hort2thefuture will address these 3 challenges over 4 years with research supplier retail and grower partners representing 11 european countries activities are divided between 7 work packages corresponding to the projects key objectives together with project management the objectives are to 1 develop a methodological framework and tools for effective sustainabilitylife cycle assessment analysis 2 create and foster the commercial uptake of relatively lowcost reliable scalable growing media in horticulture using eusourced raw materials having substantially lower carbon and environmental footprints than peat 3 develop and commercialise novel products and production systems that reduce input use in horticulture 4 develop and commercialise novel products that improve soil structure and mitigate soil compaction in horticulture 5 facilitate behavioural change to more sustainable practices through living labs and policy measures and 6 communicate disseminate exploit project results effectively to 7 stakeholder audiences raising soil literacy the project will deliver outputs at trl57 for decision support and lca tools an in planta nitrate monitoring electrode new peatfree alternatives being commercialised based on wood fibre nanomicroirrigation products developed to improve irrigation efficiency and soil health as well as commercialised biological chemical and mechanical solutions to reduceprevent soil compaction restore compacted soils and improve soil structure these outcomes will help realise mission soil health objectives involving stakeholders along the whole agrifood chain and cooperation with fao
nanocarriers optimization for periocular drug delivery to the retina

the incidence of chronic visionimpairing retinal diseases is increasing due to population ageing monthly intraocular injections are the standard of care despite the important risks eg infection and haemorrhage associated with this practice a promising alternative is the periocular injection of nanocarriers which are able to enhance the permeability across the ocular membranes however as periocular administration relies on the drug transport mechanisms in the tissues to reach the target animal tests are generally needed for a prediction of drug distribution after the injectionthe researcher aims at the development of an ex vivo model of a whole porcine eye which will constitute an evaluation tool for periocular nanoformulations targeting the retina and will allow for a deep understanding of the ocular penetration paths the project will i provide a safer alternative to intraocular injections ii reduce the need for animal testing in the preclinical phase of product development and iii overcome the current limitations of mathematical models which are generally unable to predict the complexity of nanoformulations transport this msca will be implemented throughout 24 months at the university of parma and it will include two 3months secondments the researcher will be trained on pharmacokinetics mathematical models at the university of navarra and on organsonachip models at tel aviv university the selected methodology allows for a cuttingedge approach to nanoparticles design promoting the synergistic use of chemistry tools spectroscopy with medicine and biology ex vivo models 3d imaging cellular assays and engineering tools mathematical models organsonachipthe competencies acquired during the project will complement the researchers background towards the ultimate goal of becoming an expert in the development of innovative and effective ophthalmic therapeutics with a focus on alternative methods to animal testing
strengthening translational research for improved metabolic health

curbing obesityrelated diseases is one of key priorities of the horizon europe 20232024 work programme although metabolic dysfunctionassociated steatotic liver disease masld is the most common chronic liver disease and prominent manifestation of metabolic syndrome its real socioeconomic burden is likely underestimated serbia is affected both socially and economically by the increasing incidence of masld with a prevalence of 45 therefore the establishment of a center for metabolic disease research in this region is an important priority the strimhealth project aims to develop a joint research strategy of institute for biological research sinia stankovi ibiss with three leading european institutions in order to stepup and promote scientific excellence and innovation capacity of ibiss and to establish the metabolic disease research unit as european knowledge hub the project partners have multidisciplinary skills and complementary knowledge that will significantly enhance the research and management capacity of ibiss and increase its visibility attractiveness and networkingthe objectives of the strimhealth project are 1 to enhance ibiss scientific excellence by creating an impactful research framework with leading eu research institutions 2 to strengthen ibiss research capacity for forefront translational research 3 to sustain ibiss growth by improving its research management and administrative capabilities 4 to strengthen and expand ibiss networking with both academia and industry these aims will be achieved through a series of research partnerships workshops trainings knowledge exchanges and staff visits and transfer of experience between partners strimhealth project will increase ibiss research capacity in the field of metabolic disease link it to existing eu initiatives and develop a competitive multidisciplinary research unit with strong international networks
the novel and the refugee contemporary global fiction and the imaginary of border regimes

the novel and the refugee contemporary global fiction and the imaginary of border regimes narfib will investigate an emerging trend in contemporary fiction which engages with the global escalation of harsh border regimes since 911 that have sanctioned the states capacity for extraordinary measures against outsiders to protect insiders the rise of what i identify as the global border novel coincides with the acute mass displacement around the globe with an unprecedented one hundred million refugees as of may 2022 exceeding the previous years statistics by an alarming 10 million siegfried unhcr narfib conceives of the border novel as a cultural product that mediates and is mediated by the contemporary border imaginary the border novel iterates fictional spaces in which characters live out the affective and material impacts of the borders disciplinary power for these characterson both ends of the spectrum of citizenship whether refugees or core citizens of global norththe border signals the psychic and material exposure to the internal contradictions and limitations of liberal democracies in the face of their precarious futures while the figure of the refugee points to precisely where a greater number of citizens will end up that is a victim of the border narfib dwells in this problem by assuming an interlinked relationship between refugee fiction the recent escalations of border control and the ways that the border imaginary renders the political panic about unsettling the residual myth of the monocultural statenarfib will develop a transdisciplinary methodology by synthesizing the latest research in border studies literary studies surveillance studies and political psychology narfib will be conducted in the department of literature area studies and european languages ilos at the university of oslo uio and in collaboration with the supervisor of the project professor johan schimanski
beyond nucleocytoplasmic transport nuclear pores as selfregulating valves for flux across the nuclear envelope

nuclear pore complexes npcs are fundamental components of all eukaryotic cells they fuse the inner and outer nuclear membranes and form channels across the nuclear envelope their canonical function as gatekeepers of the nucleus and facilitators of nucleocytoplasmic exchange is well established i hypothesize that npcs fulfil yet another fundamental function as selfregulating valves for flux across the nuclear envelope that occurs in response to mechanical stress this yet underappreciated function may be of utmost importance to prevent rupture of the nuclear envelope and thus to protect the genomic integrity in cells that are exposed to mechanical stress i present preliminary data indicating that npc conformation responds to mechanical force exerted onto the nuclear envelope with dilation and constriction cryoelectron tomography live cell imaging and genetic perturbation will be used jointly with structural modelling to investigate on a holistic scale how npc diameter and nuclear envelope tension impact on flux across the nuclear envelope in the proposed project i will demonstrate that besides their known function as transport channels the npcs serve an important role as shock adsorbers for mechanical stress impacting the nucleus the research proposed here will enhance our understanding of how cells deal with acute mechanical stress which is relevant for cell migration metastasis mechanically active tissues and cell differentiation
demand response residential innovation for a sustainable energy system

due to the current energy crisis the eu is reaching a critical point in the energy transition with the clean energy package residential demand response dr is a promising framework whose potential is completely untapped nowadays drrises main objective is to demonstrate the benefits of dr in the residential sector not only for the endconsumers but for the overall energy system and the actors involved we will offer a holistic set of tools and services with a twofold objective increase energy efficiency via optimal management and demonstrate the benefits not only economic of dr the platform will be demonstrated in three different eu countries focusing on gathering the most diverse environments eg preexisting energy communities smart villages urban blocks of flats lowincome households etc our approach is completely aligned with the eus vision to place the citizens at the heart of the solution and empower them so that they can make selfaware decisions furthermore we have developed a methodology around a strong social component that includes a significant codesign process of the tools with the endconsumers considering vulnerable groups to provide a completely inclusive solution a first iteration in the pilots will be deployed to assess the dr benefits including the minimum required devices to do so then building on the previous results we will iterate a second time by including new hardware and dr approaches to compare the outcomes with the previous baseline this twophased methodology will allow us to take corrective measures if needed and assess the potential benefits of multiple sensors and control devices the platform will therefore reach trl78 by project completion furthermore our plan for dissemination and exploitation including communication activities contemplates building the energy helix to reach more than 150 relevant organisations and potentiate clustering activities with initiatives such as bridge and built4people
europeamericajapan accelerator development and exchange programme

eajade is a training and staff exchange network for accelerator rd within elementary particle physics the recent update of the european strategy for particle physics emphasises the need for a higgs factory a lepton collider able to study the higgs boson in detail such a machine is both a precision instrument and a discovery machine for potentially groundbreaking physics all higgs factory proposals require wide international collaboration for their implementation and 510 years of design refinements and technical developments before construction the relevant expertise and infrastructures are globally distributed and a wide interdisciplinary and intersectorial network is essential to make progress and train future experts in the fieldeajade makes use of international staff exchanges as a vehicle to efficiently boost technical progress exploit facilities worldwide create unique training opportunities and build strong collaborations with japanese and american scientists and with industry partners in europeaccelerator rd and the realisation of future machines like a higgs factory are truly global endeavours relying on expertise in a broad set of fields and a number of stateoftheart technologies future facilities also need to carefully address their co2 footprint study the use of renewable energy sources and of energy efficiency and aim to become models of sustainability these challenges require intersectoral efforts and development of best practiceseajade is expected to lead to important and innovative advances for accelerators and the related hightech industry with substantial benefits also for other disciplines where accelerators are about to become key instruments it will also help develop a more performant and sustainable european knowledgebased economy by providing toplevel training to many physicists and engineers and through the efforts to reduce the energy consumption of accelerator technology used in numerous facilities
massively parallel joint endtoend bayesian analysis of past present and future cmb experiments

detecting inflationary gravitational waves from the big bang and mapping cosmic structure formation rank among the most important goals in modern cosmology and detailed cosmic microwave background cmb measurements is a uniquely powerful probe of these effects however the predicted signatures are tiny and their detections require unprecedented instrumental sensitivity and systematics control in this project i propose to develop one single massively parallel endtoend framework for the joint analysis of past present and future cmb experiments and use this to combine current data from wmap planck lfihfi and others with forthcoming measurements from simons observatory so all processed at the level of time ordered data tod i will also prepare for the analysis of future cmb experiments including litebird cmbs4 and a voyage 2050 cmb spectral distortion probe this framework will build on an open source bayesian cmb gibbs sampler called commander that has already played a transformational role in the field for more than two decades and that has recently been used successfully to derive new stateoftheart frequency maps for both planck lfi and wmap however the existing code only scales well up to o100 computing cores and i propose in this project a new organization that will scale it up to o100000 cores as required for nextgeneration experiments i will also implement a wide range of groundbreaking todlevel corrections for key systematic effects nonlinear adcs cosmic ray glitches atmospheric fluctuations detector crosscorrelations etc that optimally exploit synergies between experiments once operational i will use this global framework to establish a new stateoftheart model of the microwave sky shed new light on several hotly debated lcdm tensions and perhaps make the worlds first detection of primordial gravitational waves this work represents a paradigm shift in the field of computational cosmology
kidney disease sweat sensor patch for early diagnosis and remote monitoring

human sweat is abundant with biomarkers with information about underlying health conditions in combination with the capabilities of wearable devices sweat monitoring provides a promising pathway to continuous healthcare chronic kidney disease ckd is a longterm condition in which waste cannot be removed from the blood stream and can lead to recurring infections and early cardiovascular disease it affects over 100 million people in europe alone and can go unnoticed until severe symptoms appear thus there is enormous potential to develop noninvasive mass screening technologies for early diagnosis and monitoring leading to preventive treatmenthere we propose a kidney disease sweat patch for early detection and remote monitoring kermit by merging three main concepts the development of a costeffective and disposable sensing platform with minimal environmental impact the unobtrusive detection of 3 ckd biomarkers cystatinc creatinine and urea from sweat and the association of sweatbased concentration with blood levels symptoms and overall disease progress the simplified disposable platform includes an iontophoresis device to produce sweat a microfluidics collection system and a single chip to power read analyze and wirelessly transmit data from various electrochemical sensors through smartphone rfnfc protocols the manufacturing through scalable printing techniques with sustainable materials ensures costeffectiveness while minimizing and environmental impact after disposal through quantitative comparison with standard testing methodologies the proposed system is envisioned to increase the knowledge and validate sweatbased noninvasive diagnostics for ckd and a variety of diseases this will allow invasive routine screening of populations at risk and remote health monitoring opening opportunities for targeted hospital and government health programs
sustainable lunar metal oxygen and cement extraction methodology development

raw materials scarcity and the geographical dependency for critical materials is a growing concern within the eu as demands for materials and minerals keeps on increasing directing our view to space becomes an option to be considered humankind has continued to expand its reach beyond earth for which establishing a permanent base on the moon is necessary launching technology has a large economic and ecological footprint producing resources such as metals cementlike materials and oxygen in situ on other planets is thus required and should happen in a sustainable way but testing the processes under the relevant conditions is timeconsuming and expensive or if executed on earth impossible this is currently limiting further developments of these processes modelling can play a pivotal role in this but the limited previous research did not focus enough on correct input data or experimental validationthe current proposal will for the first time develop a terrestrial methodology to enable the design of a method to produce metal oxygen and concrete or glasssubstitutes from lunar regolith with solarproduced electricity on the moon this combination of resources being extracted will enable the development of a wastefree insitu resource utilisation process on the moon without the need for extra reactantsfor this several important aspects are currently unknown and will be investigated in detail metal and oxygen extraction heating mixing and castability of molten oxide and glass formation from molten oxide to take into account the lunar gravitation which is experimentally practically impossible to do the combined modellingexperimental approach in the proposed research is essential and to be applied for the first time in this context the process is first investigated under terrestrial conditions both experimentally and with a model which is validated with the experiments the validated model is then adapted to lunar gravity
concentration and threshold phenomena in random graphs and hypergraphs

the central theme of this proposal is the enumeration of large structures obeying a family of local constraints there are numerous wellstudied instances of this general problem in combinatorics probability theory and statistical physics we propose to study a variety of interrelated open problems spanning extremal and probabilistic combinatorics ramsey theory and large deviation theory whose unifying theme is the distribution of copies of a given graph in large random graphsthe first part of the proposal revolves around the infamous upper tail problem for subgraph counts in random graphs which has seen spectacular progress in the last few years we propose to advance the combinatorial approach introduced in our recent work on a special case of the problem to solve this problem completely and make progress on several related questionsthe second part of the proposal discusses the global structure of sparse subsets in hypergraphs we propose to prove a farreaching generalisation of the hypergraph container theorem that provides a useful description of the family of all sparserthanaverage sets we plan to use it to resolve the lower tail problem for subgraph counts in the uniform random graph and to prove a sparse analogue of the counting lemma for regular graphsthe third part of the proposal concerns the enumeration of independent sets in hypergraphs with cardinalities below the threshold for appearance of global structure in order to obtain precise asymptotics for the number of such sets we propose to extend the cluster expansion method from statistical physics to models with nonpairwise interactionsthe fourth part of this proposal deals with thresholds for fundamental extremal and ramsey properties of random graphs and hypergraphs we propose to resolve several outstanding open problems in this area that have resisted the recent dramatic advances in the field
new space for the extreme right an alternative history of western europe in the early phase of the cold war 1945 to mid 1950s

nextright illuminates how western european democracies dealt with and were impacted by the reemergence of fascism and more generally the extreme right in the immediate aftermath of world war ii from 1945 to the mid1950s these years were marked by the early stages of the cold war which encouraged some governments to adopt anticommunist measures but that season was also signed by the reemergence of a renewed threat that posed by the extreme right the latter maintained its strength and economic resources in many western european countries beyond the rightwing portuguese and spanish dictatorships as attested by the foundation of new parties periodicals and transnational networks yet this side of post1945 western european history is often underestimated nextright reverses this trend by investigating how democratic governments in western europe responded to the renewed extremeright activism relocating this issue within a broader narrative of post1945 western european history finally it assesses whether the cold war context played a role in conditioning the approaches of governments and in what terms the initial phase of decolonisation influenced the revival of the extreme rightin an era when democracy seems particularly fragile democratic governments are reconsidering their approaches to confronting extremist movements nextright therefore underscores the importance of developing comprehensive responses to such delicate issues which are associated with profound ethical questions for example whether it is right to tolerate the intolerantnextright is a multiarchival research focused on four case studies namely those of france italy switzerland and the united kingdom the aim is to explore and compare the national debates and measures undertaken in each country and to investigate the response of the fascists who developed a narrative that allowed them to continue to influence the european public sphere