Dragon09/odtu_chatbot huggingface dataset:
design of unprecedented electrophilic sf5 reagents applications in the synthesis of heteroatomsf5carbonsf5 bonds and latestage functionalization

the givemefive project will provide the next generation of fluorinated molecules that found plethora of applications in life science currently up to 50 of agrochemicals as well as 20 of pharmaceuticals contain a fluorinated motif as an example the trifluoromethyl cf3 group is one of the most used fluorinated motifs in research and development although several research programs have been dedicated to the synthesis of cf3molecules with numerous cf3reagents being developed recent reports pointed out a major stability drawback of the cf3 moiety impacting its usefulness thus developing more stable fluorinated motifs that could replace the cf3 group is urgent in this context pentafluorosulfanyl sf5 motif is considered as a super trifluoromethyl motif since it is more stable than the cf3 motif however two major drawbacks should be overcome to unlock the potential of sf5 molecules i current direct methodologies to introduce the sf5 motif rely on scarcely commercially available and highly toxic sf5cl a sf5 radical precursor and ii this precursor features a very limited reactivity although the availability and toxicity concerns have been recently addressed in my lab by developing an in situ protocol to generate and use sf5cl the problem of poor reactivity remains here i propose to tackle this challenge by designing new more sustainable and stable electrophilic sf5 sourcesto provide the first general direct synthesis of sf5molecules we will1 synthesize the first shelfstable family of reagents prone to be sf5 electrophile donor 2 apply the new shelfstable reagents to forge heteroatomsf5 bonds3 develop a copper catalyzed approach to forge csf5 bonds using our shelfstable reagents this endeavour could provide the first direct general synthesis of sf5molecules paving the way to the next generation of fluorinated molecules hence it will foster developments of agrochemical pharmaceutical as well as material containing sf5 motif
strategies for optimised bioprinting of next generation tissues for urethral regeneration and translation strongur

strongur aims to revolutionise surgical tissue reconstruction by producing nextgeneration bioprinted tubular tissue constructs focusing on urethral tissue engineering urethral strictures affect approximately 06 of the male population leading to persistent physical and psychological impairment in patients and imposing a significant economic burden on healthcare systems the lack of effective techniques to heal and repair diseased urethras emphasises the urgent need to invest in innovative regenerative approaches in this direction bioprinting offers promising prospects through the production of customised tissue constructs with controlled cell composition and architecture however there is still a significant gap between laboratory studies and clinical application which is why there is currently no reliable technology available for clinical use strongur includes the development of modular scalable bioprinter components and bioinks to bridge the current gap the bioinks comprise smart hydrogels customisable to personalised urethral constructs supporting desired cellular functions and enabling noninvasive monitoring for realtime treatment assessment two different approaches are proposed a single stage in situ bioprinting approach for accelerated clinical translation and a multistage approach using gmpmanufactured components to induce vascularisation and promote tissue healing in addition a novel bioprinted in vitro urethral model is proposed as a humanbased testing platform for more ethical and reliable preclinical assessments the project is in line with eu health policy addressing unmet clinical needs and supports a europe fit for the digital age with a 12partner consortium composed of scientists clinicians and companies contributing to the whole value chain supported by a stateoftheart infrastructure and a proven track record of successful projects in this field strongur represents the best team to deliver this groundbreaking work
mrna regulation of actin binding proteins

cell shape is mostly controlled by the actomyosin cytoskeleton composed of actin myosin and multiple actin binding proteins actinbps actinbps affect actin organisation and actomyosin contractility while the mechanism of mrna regulation of actin itself is well characterised there is little research on the mrna regulation of actinbps recently the host lab discovered a novel mechanism of dose coregulation for protein groups containing similar multivalency domains termed interstasis certain actinbps contain multivalent crich regions making them a candidate protein group for mrna regulation via interstasis i propose to investigate the mechanism of mrna regulation of actinbps in particular those with crich mrna sequences and the possibility of feedback regulationi will firstly identify rna binding proteins rnabps binding and regulating mrnas of actinbps among rnabps previously detected at the actin cortex and cell protrusions i will specifically focus on identifying rnabps binding to crich actinbp mrnas i will identify the mechanism of action of these rnabps via ribosome profiling iclip and smfish in the second part of the project i will investigate whether crich actinbps mrnas can be coregulated and a potential feedback mechanism in particular i will use combinatory multivalency reporter to ask whether actinbps can be coregulated via interstasis finally i will connect mrna regulation of actinbps to the actin organisation and processes affected by changes in actin organisation such as cell division and migration to this aim i will modulate the levels of rnabps and actinbp mrnas and use microscopy to image the effects on the actindriven processestogether i aim to further unveil molecular regulation of the actin networks during division and migration
mesoscale organisation of tropical convection

recent research has shown that the spatial organisation of convection and hence clouds at the mesoscale 20200km dramatically affects the earths energy balance and hydrological cycle this raises the question as to how the organisation of convection will change with warming and how it will influence the climate a poor understanding of the physical drivers of the mesoscale organisation of convection compounded by an inability to simulate and observe such processes has hampered our ability to articulate this challenging question let alone answer it in maestro i propose to develop observational approaches and analysis frameworks specifically designed to test mechanisms hypothesized to control the mesoscale organisation of both shallow and deep convective clouds advances in airborne remote sensing will be exploited to map the spatial structures of clouds and water vapor to interpret their coupling through the analysis of coherent structures within the clearair environment around clouds and to understand their dependence on environmental conditions this will help understand why and how convective clouds organise at the mesoscale why the organisation covaries with water vapor clouds and radiation locally and remotely and why it covaries with climate conditions by connecting observations from the airborne measurements to satellite observations and meteorological analyses the generality of the insights from the field measurements will be tested and tempered finally observational insights will be used to assess the new and emerging generation of climate models whose resolution is fine enough to represent the mesoscale organisation of convection and its interaction with climate maestro will lead to new experimental techniques for studying atmospheric processes to an improved conceptualization of the interplay between convective organisation and climate and to a critical assessment of the new generation of climate models for climate change studies
developing sustainable high performance polyurethanes with chemical circularity

since the development of the first fully synthetic plastics in the early 20th century these materials have become ubiquitous in our daily life the production of plastics has increased considerably reaching 368 million tons in 2019 and it is expected to double again by 2035 todays plastics are designed for performance cost and durability without taking into consideration their life after use this has resulted in an annual generation of plastic solid waste of 150 million tonnes tackling plastic waste problem is one of the top priorities yet most challenging objectives of the european union which has set ambitious policies ie green deal and aims to recycle 50 of all postconsumer plastics by 2025the design of plastics with recyclability built into their performance aiming for a circular plastics economy is gaining a lot of attention with specifically designed monomers reaction conditions can be used to select the direction of the monomerpolymer equilibrium therefore chemical recycling to monomer presents an attractive alternative since the polymer waste is employed to close the loop in a circular economy process that recovers the economic value of the materialthrough polyrec dr ainara sangroniz proposes to tackle this growing global challenge by developing highperformance polyurethane pu plastics that exhibit a closedloop circular lifecycle while also having performance properties comparable to those of todays poorly or nonrecyclable commodity plastics in the outgoing phase the fellow will develop an innovative class of intrinsically recyclable pus at the colorado state university under the supervision of porf eugene y x chen in the incoming phase these will then be depolymerized into their building block monomers and repolymerized back into the pus at polymat university of the basque country supervised by prof haritz sardon
data cube and copernicus data for food security and european independence

nostradamus in line with the farm to fork strategy the common agricultural policy and the european strategy for data will design develop and evaluate a scalable and robust platform for the online and realtime harvesting of valuable information derived from different data sources for developing several agricultural applications based on european and four national multidimensional datasets an automated pipeline regarding the data acquisition storage and preprocessing the developed platform will handle several open and commercial satellite datasets while employing in near realtime several serverside algorithms for timeseries analysis and valueadded geospatial maps for enhancing the sustainability performance and competitiveness of the agricultural sector through a multiactor approach nostradamus will develop a number of opensourcebased digital applications for farmers considering both edge and cloud solutions as well as a combination of the two taking into account the potential of advanced internet of things solutions and earth observation data leveraging data from various sources that enable realtime data collection and analysis farmers will be provided with actionable insights to optimize their operations and improve their yields reducing agricultural inputs utilization which will boost eu resilience independence and ecological ambitions for agriculture in addition the systematic update of this data will strengthen the monitoring of the agricultural practices and the administrative capacities in this sector moreover nostradamus will adopt a multiactor approach across the entire period of the project workshops field visits training activities etc that will continuously engage a variety of stakeholders such as farmers farm advisors it experts and scientists to reflect the knowledge gaps and needs of different groups properly and maximize the potential of deployment of the developed digital solutions and applications
next generation flexible trigeneration geothermal orc plant

the role of power heating and cooling is critical to achieve the eu objective of climate neutrality by 2050 heating and cooling represent today 46 of eu energy system that is more than 5700 twh out of which only 18 are produced with renewable sources of heating to exploit the geothermal for energy balancing at scale it is essential to focus on the best use of low to medium temperature resources because europe possesses mostly lowenthalpy resources at temperature ranging from 110oc to 170oc and they are predominantly found in sedimentary formations such as the pannonian basin or the upper rhein graben egs based geothermal can be developed anywhere across the eulow to medium temperature geothermal field developed based on either hydrothermal resources or egs can be technically exploited by binary or orc plant for power generation flexible orc operation to produce load following power is economically challenging ngel is aiming to transform a geothermal orc plant to a flexible trigeneration plant capable of both efficiently as well as cost effectively responding to the dynamic demand of power heating and cooling attributing geothermal energy as a dispatchable source to balance the power and thermal grid against the progressive integration of intermittent res ie solar wind this will be achieved through the integration of absorption chiller thermal energy storage cold thermal energy storage heat exchangers smart control and energy management system ems with ai functionalities ems will schedule the production and distribution of power heat and cooling by interacting dayahead market grid operator and analysing predicted energy demand and pricesif the ngel technology can be implemented in all of the existing orc plants in the eu around 215 twht heat can be delivered to the thermal grid which is approximately 4 of the eu current annual heat demand which corresponds to annual economic saving on ng import of 96 billionyear
euua nuclear research and education capacity building

the nurecab is 24 months csa project related to the implementation of euratom work programme 20232025 and focused on education training capacity building and networking actions to strengthen ukrainian and eu nuclear researchthe nurecab ambition is to support further integration of ua nuclear research community into european research networking and euratom research and training programme with paying attention to improvement of ukrainian education and training academic framework for human capacity building and ensuring safe operation of ukrainian nuclear installations and inclusive collaboration in fission and fusionthere are 6 specific objectives of the project quality improvement of nuclear education and training programme in ukrainereducing the gap between nuclear educational and training programme of ukraine and nuclear sector needsattracting young people to nuclear research and engineeringstrengthening cooperation between ua and eu research entities and academia to improve the participation of their researchers in euratom research and training programmeenhancing ua euratom ncp competences and communication toolsraising awareness about euratom programme among ukrainian stakeholdersthe nurecab project is divided on 6 work packageswp1 nuclear education enhancement identifying gaps and strengthening pathwayswp2 staff training for ua euratom stakeholderswp3 strengthening national and international cooperationwp4 capacity building of youthwp5 communication dissemination and exploitationwp6 project management and coordinationthe nurecab consortium is represented by 9 organization which are 5 ukrainian nuclear education universities ukrainian npps operator ukrainian nuclear society the largest ukrainian research center in the nuclear field that is a host of euratom national contact point and european nuclear education network from belgium
transition to agriculture 40 increasing crop resiliency with artificial intelligence technology

global food security challenges due to exposure to more frequent and intense climate extremes are threatening to erode and reverse gains made in ending hunger and malnutrition globally and to shake the foundations of crop production locally therefore plant breeders are under pressure to tackle climate resiliency and resource efficiency machine learningbased technologies have the potential to address these challenges and enable breeders to produce stable valueadded products which contribute to resourceefficient agriculture that can feed the world but are so far still under development and not commercially available computomics has developed xseedscore the first disruptive machine learningbased technology enabling more climateresilient varieties decreased land and water use reduced timetomarket and a competitive alternative to genetic modification with help of the eic accelerator computomics expects to reach by 2026 a turnover of 18m and 50 employees
unpacking mixedness for an inclusive history of the red sea 1800s2000s

the debate on mixedrace people is gaining momentum and the red sea located at the crossroads of africa and the middle east of the mediterranean sea and the indian ocean stands as a privileged venue to investigate mixedness focusing on a timeframe 1800s2000s marked by increasing mobilities and mixedrace unions and offspring eg afroarabs afroasians euroafricans redmix investigates the roots and routes of mixedrace people and groups through a bottomup longterm and interdisciplinary perspective to create a digital archive about mixedness in the red sea african and middle eastern studies have examined the red sea its mobilities and its entanglements but mixedness has remained marginal in their thematic and methodological debate critical mixed race studies has explored mixedness as a broad concept referring to individuals of mixed descent yet without ever digging into case studies from the red sea thus an extensive analysis of when how and why mixedrace people and groups have negotiated their position at political and social turning points in the history of the red sea is still lacking redmix aims to fill this methodological and knowledge gap by overcoming the partitioned approach to the red sea and promoting a perspective centred on mixedrace people the project intertwines african middle eastern and critical mixed race studies brings together a rich corpus of archival and oral sources scattered across europe africa and the middle east resorts to the digital humanities and contributes to the conceptual framework of mixedness by applying global microhistory and comparatively investigating different case studies through synchronic and diachronic analyses as the first comparative investigation into the history of mixedness in the red sea redmix will take an active part in the mission of writing a more inclusive history of the area one that firmly establishes the centrality of mixedrace people
circadian rhythms and their association with myopia

myopia or shortsightedness is a refractive error caused by excessive eyeball elongation resulting in distant objects appearing blurry its global prevalence is increasing rapidly and is estimated to affect half of the global population by 2050 several recent studies have suggested a link between circadian rhythms and eye development an analysis at the estonian biobank revealed a robust association between myopia and an individuals sleep timing preference or chronotype individuals with late chronotype were more likely to have myopia while early chronotype was associated with hyperopia this project chronopia aims to uncover the underlying mechanisms and directionality of this relationship it seeks to understand how circadian rhythms influence eye growth and how refractive errors in turn impact circadian rhythms the effect of circadian rhythms on refractive development will be studied in mice by employing various circadian biology paradigms with simultaneous monitoring of refractive development the impact of refractive errors on circadian rhythms will be evaluated using the mouse model of lensinduced myopia and hyperopia circadian phenotyping techniques retinal transcriptomics and ex vivo assessment of retinal circadian rhythms finally through genomewide genebased association studies this project will analyse the molecular similarities between the mouse model of myopia and human myopia this provides an opportunity to discover novel genes and pathways associated with human myopia and to determine how well the mouse model of the disease models human myopia on a molecular level by elucidating the interactions between refractive errors and circadian rhythms we aspire to contribute valuable insights into the molecular mechanisms that could guide the development of innovative preventive and therapeutic strategies to address the escalating myopia epidemic
predictive approaches for safer urban environments

safer urban environments are needed for all road users to ensure the european targets to halve road deaths and injuries by 2030 are met vulnerable road users require specific attention in an urban environment that is subject to constant change as new forms of transport and micromobility enter the system existing traffic simulation models allow changes in traffic conditions to be tested but are often vehicle and travel time focused and do not measure detailed outcomes specific to vulnerable road users and road safety city administrations and transport managers will benefit from predictive tools that allow these changes and their implications for road safety mobility and sustainable transport to be anticipated and support the associated policy regulatory and consumer response the predictive approaches for safer urban environments project phoebe will move beyond the state of the art and deliver an interdisciplinary solution that will integrate traffic simulation road safety assessment human behaviour mode shift and induced demand modelling and new and emerging mobility and telematics data into a harmonised prospective assessment framework for road safety new conditions and mobility solutions will be able to be assessed and safe system solutions tested the phoebe framework software module and knowledge products will allow dynamic safety prediction and socioeconomic evaluation that is evidencebased and simulates future scenarios and impacts simple and effective visualisation and socioeconomic modelling will provide the confidence for policy decisions and investmentcity administrations across eu will be consulted as the framework is developed and deployed the feasibility of the framework will be demonstrated in three use cases in athens gr valencia es and west midlands uk which have been selected to maximise the use of existing base traffic models potential impact and to ensure the future scalability and transferability of the solution
investigation of aggregationprone and phaseseparating systems using pressurejump nmr

the pioneering work of the baxanfinrud groups saw the development of a pressurejump system that could reliably and reversibly change the pressure of an nmr sample by 25 kbar in under 5 milliseconds the development of the system is currently at a point where tens of thousands of pressure jumps can be performed before maintenence is required which has opened the door to acquisition of multidimensional nmr datasets with convolution of pressure and time as a readilymanipulable dimension this cuttingedge technique is only currently available to a couple of nmr groups in the usa this project seeks to establish the novel field of pressurejump nmr within europe initially there will be an implementation phase followed by further development of pressurejump nmr methods to investigate aggregation prone and phase separating biological systems pressurejump nmr allows for direct observation of protein folding pathways protein aggregation kinetics phase separation behavior and both structural and dynamic information about proteins or small molecules in a phaseseparated or aggretated state and presents the opportunity to redefine the role of nmr in structural biology and biophysical chemistry