Dragon09/odtu_chatbot huggingface dataset:
stimulating and connecting the finest experimentation practices and spaces

the finex project builds on key innovation actors driving the green and digital transition eit digital europes largest digital innovation ecosystem eit climate kic europes largest climate innovation agency and community the cleantech group the worlds leading authority on cleantech innovation pairing them with worldclass crossborder research innovation centres of excellence who have been deploying experimentation testbed living labs sandboxes and acceleration tools to turn leading research into market ready innovations finest coe kios coe and gate coe as well as lithuanias leading cleantech innovation ecosystem sunrise valley science and technology park stp a perfect place for innovative technological enterprises to establish and develop businesses and riga technical university rtu the largest latvian university leader of the eit climatekic hub latvia also soon to be a eit digital centre and with a specific specialised innovation ecosystem development unit a leading actor in local and national digital and cleantech technologies innovation ecosystems with various international education business support research and networking programmeskey objectives of the finex project are1 to stimulate and interconnect the six targeted innovation ecosystems as europes cleantech powerhouse enhancing their genderinclusiveness openness competitiveness and global potential2 to jointly develop worldclass experimentation spaces and the promotion of a better aligned eu regulatory fiscal and legal framework 3 to identify and support cleantech domains and innovators requiring the development of experimentation spaces capable of supporting the quick deployment of disruptive and novel deep tech and solutions with the potential to help europe achieve climate and industrial leadership
crisprcasbased innovative electrochemical multiplexed immunosensor for specific detection of ovarian carcinoma biomarkers in urine

ovarian carcinoma oc is a leading cause of cancer deaths in postmenopausal women worldwide unfortunately it is diagnosed in the advanced stages iiiiv with fiveyear survival rate of 20 and poor prognosis due to lack of distinct early symptoms the current diagnostic tools pelvic examination and imaging techniques often fail to detect premalignant tumors and standard biomarker cancer antigen 125 analysis show low sensitivity and specificity the goal of this proposal is to develop a radically innovative modality in the field of early diagnosis of ovarian cancer i propose cuttingedge crisprcas clustered regularly interspaced short palindromic repeatscrispr associated protein technologybased molecular diagnosis as the next generation oc screening toolthe proposed crinova project will apply the crisprmediated biosensing approach for the first time combining with immunoassay to detect oc protein biomarkers cancer antigen 125 human epididymis protein 4 and mesothelin noninvasively in urine of early stage iii oc patients through electrochemistry the nucleic acid programmed nuclease activity of cas effector protein will be activated upon sequencebased recognition of guiding rna of crispr by a single strand dna in the presence of biomarkers resulting in their highly specific and sensitive detection the purpose of the project is linked to improving prognosis of oc patients making a direct impact on enhancing their quality of life this major objective will be achieved through a crossdisciplinary approach involving my wide experience in electrochemical biosensor development and the expertise of my supervisor on dna nanotechnology and crisprbased biomolecular sensors i have an excellent track record of scientific collaborations undertaking international mobility in different laboratories globally the outcome of the fellowship will be crucial to boost my career in academia and to achieve a permanent position ie professorship in europe
innovative cocreation soil health living labs

european soils face pressing conditions for their health an alarming 6070 of eu soils are considered unhealthy attributed to factors such as pollution urbanization and intensive agriculture further exacerbated by climate change this degradation results in economic societal and environmental repercussions including decreased land productivity migration land abandonment and biodiversity loss addressing this challenge necessitates holistic measures especially since soil restoration can take centuries the project initiative aligning with various eu policies emphasizes the importance of comprehensive soil restoration efforts it plans to establish six soil health living labs shells across diverse eu climatic zones including sweden spain spainfrance italy greece and bulgaria these labs are envisioned as innovation hubs tailored to address the eus specific soil health objectives notably objectives 4 6 and 8 through collaborative efforts within these shells the goal is to develop test and validate potential solutions ensuring scalability beyond their immediate regions icoshells places a strong emphasis on inclusive stakeholder engagement from researchers to landowners its systematic approach includes building stakeholder capacities bridging gaps between science and practical applications deepening understanding of soil indicators replicating effective soil recovery methods and championing supportive soil health policies additionally icoshells seeks to redefine the concept of living labs lls challenging the traditional model which often revolves around isolated research entities icoshells envisions lls rooted in cocreation broad engagement and realworld application this transformative vision aims to evolve existing shells into standardized widely recognized labs setting a foundational blueprint for future lls moreover as a comprehensive soil data repository icoshells promotes collaboration ensuring replicable
landsea interface lets observe together

landsealot will link together in situ model and earth observations eo and connect related communities citizens and initiatives such as copernicus esa eea geoss emodnet and the european digital twin of the ocean these observations will be used in a gap analysis to codesign a common landsea interface observation strategy and an implementation plan landsealot participants will simultaneously work on improving in situ and eo capabilities models to reduce the modelobservations gap and the integration of model in situ and satellite data observation capacity will be increased through tested improved and guided use of lowcost technology by citizens facilitated by the network of european marinas the technologies selected will be piloted in integration labs ils together with improved and integrated in situ and eo observation techniques and model outputs landsealot ils will cover selected areas in the black aegean mediterranean atlantic north and baltic seas with a range of catchment tidal and meteorological regimes experts and citizen science leaders will work in the ils together with jericori danubiusri and icoseric and with regional policy makers and managers to tailor integrated observations that will provide them with information to manage societal challenges these will include assessment of the lateral carbon flux and stock plastics transfer nutrients impact on primary production and eutrophication supporting biodiversity conservation improving modeling capability and supporting climate change adaptation storm surge floods heat waves coastal erosion saltwater intrusion data generated in the ils will be made fair available via emodnet and interoperability and semantic solutions for existing international data flows will be developed relevant communities will be engaged by workshops conferences training a hightech summit and by a communication strategy including videos and policy briefs to ensure landsealots legacy
3in1 selfpowered hybrid energydriven wearable technologies unifying energy harvesting and storage

in the landscape of wearable electronics there is a demand for selfpowered systems to address the challenges posed by discontinuous and limited power supply lowgrade heat and moisture are two ubiquitous clean energy sources with great potential for electrical energy production 2in1 technologies combining thermal or moistureinduced energy harvesting eh with electrochemical energy storage es are attractive selfcharging solutions for wearables however their performance remains inconsistent and unsteady the understanding of the underlying eh and es mechanisms remains fragmented without considering synergistic opportunitiesselfenergydriver proposes a pioneer hybrid textile technology unifying moisturetriggered eh thermal eh and supercapacitive es this groundbreaking 3in1 concept aims for the selfsustained harvesting of two clean energy sources and simultaneous in situ storage of the captured energy nontoxic multifunctional hybrid electrode nanomaterials with 3d porous architecture redoxactive nature and precisely engineered moisture permeability thermal and electrochemical properties will be developed to comply with all ehes requirements these hybrids will be incorporated in textiles and assembled with advanced redoxactive ionic hydrogel polyelectrolytes in innovative device architecturesselfenergydriver will delve into the intricacies of electrodes electrolytes and their interfaces to guide the rational design of these trailblazing technologies and foster cooperative effects for synergisticallyenhanced outputs the supreme goal will be bridging the knowledge gap between electrodeelectrolyte properties interface phenomena device architecture and performance as a proofofconcept the 3in1 technologies will be tested under simulated realworld conditions to showcase their potential to revolutionize the landscape of wearable energy systems the acquired knowledge will set new landmarks in clean energy textronics and sensing
ecoepidemiological intelligence for early warning and response to mosquitoborne disease risk in endemic and emergence settings

mosquitoborne diseases place a heavy burden on society causing widespread suffering and driving poverty they are increasing in prevalence geographical distribution and severity representing a growing threat worldwide hence there is a need for better disease intelligence capable of anticipating and identifying ecoepidemiological risks leading to explosive epidemics and emergence in previously unaffected areas the basis of such intelligence stems from a deep understanding of the factors that drive disease circulation emergence and spread this requires insights into the complex interplay between humans pathogencarrying mosquitoes pathogen reservoirs eg birds and a changing environment the e4warning consortium brings together interdisciplinary innovative and open science to contribute to the one health paradigm shift that is required to tackle the spread and transmission of zoonotic deadly pathogens and harness this shift to nowcast and forecast mosquitoborne disease risk in a constantly changing and globally connected environment our work aims to disrupt disease transmission pathways connecting humans mosquitoes and birds through innovative ecoepidemiological modelling tools and intelligent digital solutions codesigned and implemented by public health administrations open innovation strategies and big data tools are the cornerstone of the nextlevel one health early warning systems required in the face of mounting mosquitoborne disease threats
strengthening regional stem cells based research for advancement of multi modal innovative strategy for modelling neurodevelopmental disorders

neurodevelopmental disorders ndds caused by alterations in early brain development are a group of complex and heterogeneous disorders that give rise to the psychiatric conditions such as autism spectrum disorders intellectual disability schizophrenia and bipolar disorder ndds have a high socioeconomic impact and patients with ndds and mental health problems are geographically dispersed thus establishment of high capacity regional centres with equivalent research capacity and codes of practice is needed in order to build global research activity the goals of streamline are to enhanced strategic networking and reinforce research and innovation potential of the institute of molecular genetics and genetic engineering imgge in order to develop imgge as a high capacity hub for research of ndds in the western balkans which is able to integrate with similar centres in europe this will be achieved by twinning imgge with three topclass research institutions in europe cardiff university university of maastricht and centre for research and technology the project objectives are a to enhance the current and scale up the overall strategic networking activities between the imgge and internationallyleading european partners and regional partners b to raise the research profile of research stuff and scientific attractiveness of imgge in the field of ndds c to strengthens research management capacities and administrative skills of the imgge staff and d to become a regional leader in innovations tackling ndds objectives will be achieved through networking staff exchanges training summer schools symposia workshops participation at conferences and dissemination in scientific community industries and public twinning with partners will provide access to new research avenues creativity development of new approaches and increased mobility inwards and outwards of qualified scientists
measuring and understanding disparities in family formation in low and middleincome countries

the first union formation and the birth of the first child are among the most critical events shaping mens and womens lifecourse trajectories sustainable development goals sdg stress that all individuals should have access to means that allow them to control their fertility and should be able to marry at an age that does not harm their development capabilities central to sdgs is eradicating disparities in the timing of family formation yet the understanding of their global patterns and determinants is limited particularly in low and middleincome countries lmics this is a critical research gap as many women in lmics enter their first union and become mothers very early in life and much earlier than men which puts them at risk of adverse health outcomes focusing on 69 lmics this project aims to radically improve our understanding of global family changes by providing novel empirical evidence on a critical yet poorly understood topic namely using nuanced indicators i will deliver the firstever global examination of changes in disparities in the timing of family formation both within and between the populations of women and men subsequently i will investigate the role of an underresearch dimension of education schooling quality and the role of gender inequality in opportunities in driving these disparities this project will straddle the disciplines of demography sociology and international development to produce cuttingedge research that will improve the scientific understanding of social inequalities by delivering novel evidence about the role of educational and gender inequalities in shaping young adults family formation trajectories this project will be of value to the wider research and policy community including organizations such as the un it will inform public policy on causes and solutions to critical global problems affecting millions of individuals worldwide such as very early marriage parenthood and gender inequalities
social media narratives addressing extremism in middle age

conspiracy theories misinformation and extremism online is a growing concern to governments extreme political narratives have been rising across europe and these narratives influence mainstream political discourses and policies this is having a direct impact on perceptions of democratic institutions trust in science and leads to calls for direct action jan 6th incursion in usa to overthrow or disrupt democratically elected governments those in middle age 4565 may be both susceptible to extremist narratives and also influential as decisionmakers this group is underresearched but the impact of them being drawn into extremist content may have significant consequences on political discourse democratic processes and institutions smidge will analyse the various forms of extremist discourses and narratives across europe through social network analysis textual and content analysis of extremist discourse and will consider national and demographic specifics through survey focus groups and interviews in 6 countries uk italy belgium denmark kosovo cyprus from this indepth examination of the current state of the art smidge will produce counternarratives education and training resources aimed at promoting reflexivity alongside multilevel policy recommendations and evidencebased tools and training for journalists and security professionals the countercontent will be created through collaboration with stakeholders during cocreation exercises in the focus groups smidge takes the theory of responsible research and innovation rri as its core conceptual approach to ensure that the project adheres to the highest ethical and quality standards the outputs from smidge will provide evidencebased content tools and resources that will directly help to counter extremist narratives from multiple perspectives thereby providing greater understanding of the specificities and characteristics of those in middleage and their vulnerability to extremism online
career accelerator for research infrastructure scientists 2nd generation

the arise2 program will train 50 postdoctoral fellows for roles as research infrastructure ri scientistshighly skilled and muchneeded scientific experts responsible for developing providing and managing scientific services in the life sciences europe has made significant investments in ri development necessitating dedicated programs that will produce qualified experts to drive these advancementsbuilding upon the success of the mcsasupported arise program arise2 continues its mission to train researchers for ri roles selected fellows will develop novel technologies and methods that enable faster more precise analyses across multiple life sciences fields accelerating our understanding of life from molecules to ecosystems as life sciences ris are generating large volumes of data we are introducing data science and ai as a new focus in arise2 fellows will be challenged to simplify and ideally automate fair data management for the benefit of users ultimately leading to greater fairification and improved data integration for european researchers they will be supported by their supervisors and advisors from embl and 17 arise2associated partners 9 nonacademic who engage in collaborative projects hosting intersectoral and interdisciplinary secondments or participating as trainers thereby increasing competencies infrastructure supervision and exchange the implementing partner will lead arise2 training and the development of further partnerships in addition to training through research fellows will benefit from a unique training portfolio to acquire ri professional competencies including data science and ai scientific and transferable skills and opportunities to foster professional networks arise2 will generate open and microcredentialready training materials facilitating the expansion of similar ri training programme across europe and standardising this new career path in research
quantitative stability and regularity of large data for conservation laws

the proposed project will focus on the wellposedness theory for hyperbolic systems of conservation laws in multiple space dimensions the project will consider the stability and wellposedness theory for such systems in the cases with and without sourcein his 2023 survey of the field dafermos writes that in regard to systems of conservation laws in one spatial dimension the fundamental question whether the cauchy problem in the bv setting is wellposed for initial data with large total variation remains wide open our program to study quantitative stability will allow us to consider not only large bv solutions but also large l2 solutions with infinite bvclassically the best theory of wellposedness for hyperbolic systems in one space dimension is the l1 theory of bressan and coworkers which considers smallbv solutions recent results of the researcher chen and vasseur go significantly beyond the classical smallbv theory and are able to treat even large l2 data the theory uses the technique of acontraction and the key assumption is a strong trace condition a regularity assumption strictly weaker than bvloc our first main objective in this proposal is to quantify the stability in the acontraction theory which hasnt been done so far more precisely objective 1 quantitative stability in the setting of large data derive quantitative stability estimates between l2 and bv solutions for a large class of systems in one space dimensionthe strong trace condition is the key boundary between general weak solutions and the solutions we can show uniqueness for this brings us our objective 2 regularity for scalar conservation laws possibly with nonlocal or unbounded source under mild technical assumptions show the existence of the strong tracesthis is open even in the one dimensional scalar case with unbounded source showing the existence of strong traces would be a significant step towards the program of dafermos
herit4ages usercentric and datadriven retrofitting solutions for a resilient energyefficient lowemission and inclusive cultural heritage

for decades heritage buildings have been an example of resilience but also low emissions and the core of our cities towns and villages a building that has no use or purpose is abandoned and lost it is imperative to ensure their conservation and maintenance by making them accessible affordable and easy to maintain but also habitable and that is only possible considering comfort as the main target heritage buildings represent an important part of our cultural identity it is time to include them in the adaptation to a new social and energy model this project aims to demonstrate that it is possible to improve the overall performance of heritage buildings while preserving their architectural and cultural identity given that the spectrum of heritage buildings is very broad and those protection laws may allow for different levels of intervention the project aims to develop a set of solutions that can be replicated in different parts of europe the idea seeks to solve the problem of lack of comfort experienced in many heritage buildings where in many cases either there is no heatingcooling system or the use of the existing one entails a significant economic expense due to the need to aircondition large volumes of air achieving acceptable levels of comfort is something that will not only benefit the health of the users but will also help to make these buildings attractive places to develop different uses and thus help to preserve them when we are faced with the energy rehabilitation of a heritage building in which we normally have construction elements with high thermal inertia the most recommendable solutions to take advantage of this characteristic are usually to insulate the exterior with hygroscopic materials unfortunately in many cases this intervention is not possible due to problems with the alignment of the street or because the façade is protected when the only solution is to insulate on the inside other problems arise such as humidity buildup