Dragon09/odtu_chatbot huggingface dataset:
a novel multistage steam gasification and syngas purification demonstration plant for waste to hydrogen conversion

europe faces the joint challenge of decarbonising ever newer sectors and applications whilst also seeking clean waste treatment and valorisation pathways with over 300mt of waste generated each year europe could produce up to 30mt of clean hydrogen from waste to accelerate the decarbonisation of challenging sectors like aviation and heavy industry however exploiting this energy potential remains a challenge and so far no robust and costeffective solutions has been successfully commercialised hyield aims to open a new lowcost pathway for clean hydrogen production and waste disposal the project proposes a novel multistage steam gasification and syngas purification plant concept which will efficiently convert different organic waste streams into hydrogen and is expected to achieve h2 9997 purity and 6274 energy conversion efficiency the concept includes several beyond stateoftheart innovations including a novel process design waste heat exploitation watergasshift membrane reactor lowpressure metal hydride storage buffer and ia driven digital twin the solution will be implemented at 3mw scale in a cement plant in spain where the hydrogen will be exploited for cement kiln firing the demonstrator is expected to operate for 4000h over a 15month testing period with at least 10 different organic waste streams treating over 39kt of dry material and producing 650t of hydrogen it will also carry out the groundwork for upscaling postproject locally and across the eu working closely with industrial partners from the cement steel copper and gas sectors it is forecasted that the solution will be able to deliver a levelized cost of hydrogen of 219kg at industrial scale 20000tyear waste treated far below current electrolyser pathways 55kg the project is led by a consortium of europes leading research groups technology developers and industrial players in the hydrogen sector from spain france germany norway and luxembourg
choreographies for distributed systems reasoning expressivity and development

decades of research in computing led to highlevel programming languages that can turn a programmers ideas into executable software for applications that run in isolation we have a solid toolbox we can write code with abstract concepts like functions and objects and then a compiler tool can automatically produce working implementations this significantly increases productivity facilitates program analysis and reduces the risk of bugstoday society increasingly relies on distributed systems for work services social participation and so forth here the key highlevel concept is that of communication a message exchange between independent programs yet it is nowhere to be found in the syntax of modern programming languages instead we manually write lowerlevel instructions for sending and receiving messages in separate programs hoping that they match each other during execution and produce the wished communications this is infamously hard leaving us with code that is difficult to write or trustthis situation is not due to lack of trying choreographic programming is a recent attempt at a programming paradigm with highlevel abstractions for communications and their composition in programs called choreographies unfortunately compiling choreographies is technically challenging which resulted in excessive simplification current theories make unrealistic assumptions remaining confined to toy scenarios and reasoning methods for choreographies are underdevelopedthis project will break new ground by developing a new linguistic constructs for choreographies that can deal with realistic scenarios b logics for verifying properties about choreographies and understanding what they mean for the compiled code and c a toolchain for compiling testing and deploying software based on our choreographies these actions have the potential to significantly impact how we will model and program distributed applications in the future
reconstructing roman road network for the understanding of urban development

the roman conquest occupation and dominion over a large part of current europe and beyond marked a strong change in social cultural and economic patterns in the area two of the most important and lasting changes were the establishment of a new transport network and the largescale development of cities connectivity continues to be seen as an essential factor in the analysis of the spread of urbanisation migration the ancient economy and the transmission of ideas in antiquity connectivity could only be achieved via movement by land river and sea and had to rely on the available transport network however to date no analysis of communication trade distribution of people and resources or the economy in general exists that actively considers the transport network the single element that made connectivity possible on an empirewide scale and therefore no attempts have been made to understand its influence on urbanism or its longterm influence this is largely due to the lack of complete reconstructions of roman route systems although much is known about the roads and other elements of the roman transport network this knowledge is partial and lacks integration the road transport network is full of empty spaces and broken links that prevent the development of an integrated system fit for largescale analyses and the use of quantitative and computational approachesr3nurb will address these problems by reconstructing the whole roman transport network and using it to analyse the influence of connectivity on the process of urbanisation urban distribution and the long term success of urban centres for this r3nurb will employ an innovative combination of computational approaches remote sensing network science and geostatistics this approach will provide unique insights into mobility transport and urbanisation at a panroman scale and therefore open up new horizons in the study of connectivity and urbanism in the past
a complex systems approach towards resilient and connected vulnerable european communities in times of change

europe is facing a number of global challenges such as digitalisation migration and climate change which increase demands on citizens resilience and puts them at risk of developing mental health problems reconnected responds to this problem by developing and testing a digital support system to promote resilience and connect vulnerable citizens in socially disadvantaged communities and evaluate whether this results in citizens improved mental health increased mental health awareness reduced stigma and improved social participation at affordable costs for implementation taking a complex systems approach the project will first extend and test a recently developed theoretical integrative framework of urban mental health to include mental health responses to global transitions this will provide a good understanding of how risk and protective factors at the individual social environmental and societal levels interact dynamically and impact on mental health the framework will provide actionable insights for policy decision making and will be used to develop a support system with intervention tools targeting individual and social levels simultaneously the platform will be cocreated with stakeholders in the local community in nine european countries these interventions will be nonstigmatising and empowering and tailored to the needs of the local community reconnected will test the feasibility and effectiveness of the support system in these communities and in the final stage develop implementation scenarios that balance effectiveness with efficiency and scalability to inform policy decision making that can be used throughout europe the methodological approach in the project is theoryinformed and datadriven and we will use cocreation throughout the project to ensure that actionable insights and intervention tools are relevant acceptable and ethical to endusers and other stakeholders
exploiting the activity of the aldh enzyme to develop highly selective drugs for cancer stem cells

despite huge advances in cancer treatment resistance to chemotherapy is still common it is now well established that a small population of cells named cancer stem cells cscs have high tumorigenicity and are able to initiate and maintain a tumour cscs usually remain in a quiescent state that is not affected by standard chemotherapy thus they are often responsible for treatment resistance and relapse there is a clear need to find effective treatments against cscs to fully eradicate the tumour however the close similarities of cscs to healthy stem cells hinders the identification of selective drugsin the last years new drug modalities are emerging to provide therapeutic options for challenging targets and diseases expanding the drug discovery landscape in line with these trends selecstem aims to develop innovative chemical biology strategies to target cscs in a safe and effective manner it will exploit the activity of the enzyme aldh which is overexpressed in cscs of many cancer types to obtain selective drugs using three orthogonal strategies we will use the oxidoreductase activity of aldh to trigger the selective 1 accumulation or 2 release of drugs inside cscs and 3 use external light to inhibit aldh only in the tumour area successful strategies will be combined at the end of the project to overcome potential limitations of the individual approaches hence massively increasing the drugs selectivity and efficacy we will design these molecules with the aid of docking studies synthesise them and assess their aldh or lighttriggered activation in purified enzyme assays and in csc spheresoverall we will develop the proof of concept of unprecedented approaches to eliminate cscs with outstanding precision thus overcoming some of the limitations of conventional small molecules going beyond stateoftheart chemical biology our ultimate goal is to contribute to improve cancer treatment and increase complete remission rates
development of a nanobodybased slidefree approach for 3dhistological analysis of the spatial tumor microenvironment using lightsheet imaging

for histopathological analysis and subsequent diagnosis of diseased tissues a rapid accurate histopathological and genetic analysis of biopsied tissues are essential however traditional 2dimensional slidebased histopathological analysis does not represent spatial tissue structures and molecular targets sufficiently which aggravates an accurate and spatial analysis of tissue a detailed description of the tumor microenvironment as well as patient stratification to overcome these limitations i propose an innovative nanobodybased 3dhistopathology approach using nondestructive volumetric lightsheetmicroscopy this approach bears the potential to revolutionize the way pathological analysis of tumor samples are done in comparison to conventional 2dpathology nondestructive 3dhistopathology allows rapid slidefree histological imaging of an entire tissue sample volumetric analysis of diagnostic relevant structures such as immune cells vessels and an improved spatial analysis of cell distribution relevant to study eg the microenvironment to achieve this we will generate nanobodies for improved wholemount tissue staining of the immune system as well as tumorrelevant markers by labelling nanobodies with cleavable fluorescent dyes using click chemistry and integration of linkers for stoichiometric and directed labelling we will be able to perform several rounds of multiplex staining of the identical sample and therefore provide cuttingedge diagnostic phenotyping of the specimen due to nondestructive nature of the opticalsectioning methodology the sample is available for downstream applications such as molecular diagnostics of the previously imaged specimen in summary this innovative project holds the great potential to revolutionize cancer histology by providing a spatial and detailed description of the tumor microenvironment improving diagnosis of tumor samples and consequently patient stratification and outcome
identifying and interpreting underground conditions in southern european countries for thermal storage through aquifer thermal energy storage systems

the atesseum project addresses knowledge gaps regarding aquifer thermal energy storage ates systems viability in southern european union member seum states ates systems store thermal energy in aquifers for building heating and cooling but face challenges like groundwater fluctuations climate change impacts and complex legislation the project aims to develop a common methodology for seum countries to evaluate ates systems potential considering the specific impacts of climate changeto achieve its goals the project works with experts at delft university of technology tud and the geological and mining institute of spain with knowledge sharing in italy and greece it responds to the need for renewable alternatives to heating and cooling especially in waterscarce seum countrieschallenges include excessive groundwater demands for irrigation climate change effects and legislative complexities in seum states spain is the primary study region with additional case studies planned in italy and greecethrough interdisciplinary research training and knowledge dissemination atesseum aims to enhance methods and knowledge related to ates system suitability in waterscarce regions it aligns with eu sustainability goals and emphasizes the integration of renewables and technologies to reduce energy consumption and emissions additionally it aligns with the eu water framework directive by studying groundwater aquifers current and future statesthe projects objectives include assessing climate change impacts on groundwater evaluating aquifer suitability generating suitability maps and transferring results to influence energy policies and regulations in seum states
clinical readiness of a live biotherapeutic for treatment of nonsmall cell lung cancer nsclc

nonsmallcnonsmallcell carcinomas nsclc represent 8085 of the worldwide lung cancer cases which are the leading cause of cancerrelated death several clinical trials have indicated better survival rates in nsclc patients treated with immune checkpoint inhibitor ici antibodies targeting pd1pdl1 or ctla4 however since many patients display innate or acquired resistance to these therapies there is a pressing need to discover methods to help them overcome the resistance founders of pulmobiotics a spinoff created as a result of an erc poc project have shown their ability to engineer and produce a nonpathogenic strain of the mild human lung pathogen mycoplasma pneumoniae the mycochassis used to stimulate the immune system to promote t cell infiltration in the tumor the developed mycochassis also secretes different immunomodulators il2 il12 and flt3l in a sustained and local manner directly to the lung tumor overcoming their high systemic doses of toxicity in patients pulmobiotics has further optimized the mycochassis to meet safety requirements engineered a development candidate product pblc for lung cancer treatment and developed analytical methods to analyse its replication and biodistribution in vivo critical regulatory requirements the specific objectives of this eic transition proposal are to establish processes for manufacturing formulation and inhalation delivery of the product that meet gmp standards to do preclinical regulatory activities including efficacy safety and pharmacokinetics pharmacodynamics as well as to advance the market and business preparation for the commercial exploitation of the first product of the company pblc achieving the project objectives will pave the way to take pblc into firstinhuman clinical trials and license the product to reach the market the use of pblc will positively impact the quality of life of nsclc patients by increasing the efficiency of currently used immunotherapies
industrialisation of building lifecycle data accumulation numeracy and capitalisation

significant challenges affecting the building and construction value chain are related to fragmentation and siloing a systemic change is needed catalysed by lifecycle perspectives that will reveal interactions opportunities and threats inblanc will establish an open ecosystem focused on capitalising on the economy of building lifecycle data this will be achieved through the accumulation framework inblanc prioritises lowcost data collection options and data extraction and inference the consolidation of building information in building digital logbook as well as the creation and population of databases interfaced with eu dataspaces through connectors the numeracy component will implement a nexus strategy to map and operationalize interactions between different types of metrics energy human societal economy environment circularity and resilience six target groups encompassing the entire value chain with focus on building owners and facility managers as actors with major decisionmaking capacity the building lifecycle data capitalisation toolset integrates highadded value services for the comprehensive management of energy planning and operation virtual facility management quantified indoor health lowcarbon renovation planning and urban context integration actors in the ecosystem will be engaged across the value chain through a holistic engagement strategy that will embed the projects outcomes in current and future industrial but also user needs inblanc will be demonstrated in six demo cases reflecting six very different usecase scenarios from heritage renovation to education to energy flexible neighbourhoods public building portfolios large scale health facilities and finally cityscale implementation through the ambitious demonstrations feedback will be collected and incorporated into a system completion process to prove nearmarket readiness
the politics of urban regime construction in spain 20152019

the politics of urban regime contestation provides the first systematic assessment of attempts by spanish new municipalist movementparties to consolidate progressive urban regime change between 2015 and 2019 new municipalism represented a political wave of astonishing proportions unseating neoliberal regimes led by traditional political parties in eighteen cities with more than 20000 inhabitants including key urban centres such as barcelona and madrid municipalist administrations experimented with the cooperative economy sustainability initiatives feminism and democratic revitalization they produced multiple cases of attempted urban regime change understood as the process of creating resource coalitions capable of transforming urban governance and political economy this study provides novel and timely data and theory to understand the politics of urban regime contestation the success of municipalist platforms in 2015 provided inspiration for an international movement but is marked nationally by widespread electoral defeat in 2019 municipalist administrations achieved electoral continuity in just two cases barcelona and cadiz outcome variation provides opportunities for comparative analysis into the dynamics of urban governance continuity and change theoretically urban regime theory is used inorderto understand how new municipalist coalitions and agendas interacted with urban governance relationships and institutions the project builds on empirical pilot research into two cases using a tried and tested methodology recently published in urban studies adding qualitative comparative analysis to explain varying degrees of success across the entire population of cases in using this theory and method the project promises to provide an overarching yet detailed assessment of the topic it will develop knowledge critical for deepened urban democracy sustainability and social justice a valuable contribution to horizon europes strategic ambitions
artificial molecular machines in membranes transmembrane relays for ion transport catalysis and cargo pumping

this program will develop artificial molecular machines confined within lipid bilayer membranes to control transmembrane transport and catalysis in cellular systems molecular machines are ubiquitous in nature at the heart of many biological processes are protein machines confined within biological membranes which drive nonequilibrium transmembrane ion pumping via the consumption of chemical fuels biology has evolved to utilise the controlled nanomechanical motion of molecular machines to mediate numerous complex tasks in the cellular environment a clear indication of the immense technological potential of synthetic systems that work in a comparable way despite this fundamental importance synthetic molecular machines able to facilitate outofequilibrium pumping of ions have not been developed to address this key challenge this project seeks to develop synthetic analogues of biologys membrane pumps artificial molecular machinery that can interface and be manipulated within lipid bilayer membranesits objectives are to developmolecular machine ion transport relays able to pass ions and catalysts across lipid membranesstimuliresponsive mechanicallyinterlocked ion and molecular transport shuttles molecular machine transmembrane pumps capable of nonequilibrium active transportbesides crucial impact to the rapidly expanding but to date surprisingly distinct fields of molecular machines and membrane supramolecular chemistry the results from this project will enhance our understanding of nonequilibrium processes within and across lipid bilayer membranes we anticipate that the systems developed over the course of the grant will provide the basis for the longerterm development of novel tools for applications in chemical and synthetic biology such as to regulate the flow of material in and out of artificial cells and in systems chemistry applications which enable the nonequilibrium manipulation of matter at the nanoscale
characterising heterostructures and integrated methodologies for electronic realtime analysis in 2d materials

the next wave of electronic quantum devices requires the development of solidstate systems showcasing distinct quantum properties the ongoing intensive research has pinpointed promising quantum systems in 2d materials particularly those derived from transition metal dichalcogenides tmds their properties are typically investigated in two distinct and separate phases initially electronic states and transitions between them are studied through optical spectroscopy the material is then embedded in a device whose electrical response is characterised by using electron transport spectroscopy this workflow however fails to capture events such as grain boundaries formation defects and carrier scattering sources that happen when the device is operating and are major factors for performance deterioration and energy wastage as a result the correlation between material structure modifications and quantum properties remains largely unexplored this action seeks to bridge this gap by merging both techniques into a unified realtime methodology i will produce wafersized tmds layers using a novel synthesis technique compatible with industry routines for largescale manufacturing i will then fabricate tmdbased fieldeffect transistors and monitor the optical response of the channel whilst charge carriers flow through it this will provide a fundamental understanding of rapid ageing effects in nanoscale transistors ultimately using this knowledge i aim to fabricate energyefficient logic gates with tmds