Dragon09/odtu_chatbot huggingface dataset:
interplay of multiplicative number theory and additive combinatorics

this project concerns multiplicative number theory and its interplay with the emerging topic of additive combinatorics multiplicative number theory is an area of number theory concerned with the study of prime numbers and multiplicative functions one of the most important unsolved questions in this area and in all of number theory is the twin prime conjecture asserting that there are infinitely many pairs of prime numbers differing by two in 1965 chowla formulated an influential conjecture that can be viewed as an approximation to the twin prime conjecture chowlas conjecture predicts that the prime factorisations of consecutive integers behave independently of each other this conjecture captures the key difficulty in the twin prime conjecture but yet there has been a lot of recent progress on chowlas conjecture by the applicant and others the aim of this project is to make substantial progress on chowlas conjecture as well as on other key questions in multiplicative number theory using a mixture of methods from analytic number theory and additive combinatorics as well as higher order fourier analysis a theory recently developed by green and tao connections between chowlas conjecture and questions in additive combinatorics and higher order fourier analysis have recently been discovered in works of the applicant and others and the proposed research aims at exploiting these connections to make substantial progress on chowlas conjecture the project also involves several other problems of interest in number theory such as the hardylittlewood conjecture on average and the hasse principle for almost all surfaces of a certain type
highly multiplexed quantitative protein biomarker profiling hmqpro

the project will develop a multipurpose highly multiplexed quantitative protein profiling hmqpro platform that can be adapted to a wide range of applications particularly biomarker discovery biomarkers are a 43 billion usd market spanning applications in diagnostics drug discovery development personalized medicine disease risk assessment the method comprises an antibodybased profiling of a large number of proteins or protein posttranslational modifications against a large number of samples irrespective of source unlike competitor methods hmqpro does not require platformspecific assay or detection equipment dual multiplexing implemented in a variant method hmqpro2d will make the platform competitive against existing protein profiling methods in perassay cost flexibility and scalability the hmqpro platform uniquely complements the technology portfolio of epigenica ab and we will chart out two commercialization routes first hmqpro will be integrated into a service laboratory offering highthroughput sampletoresult epigenome and protein profiling services to academia pharma and biotech industries second we will package the method in a kit format distributed to rd and clinical end users in summary the proposed project will deliver a new quantitative protein profiling platform that will have the capacity to impact the biomarker discovery market by combining unique flexibility with highthroughput
an intelligent platform for integrating climate services

according to water europe statistics 90 of the global economy and 75 of jobs depend on water while waterrelated risks are among the top 5 risks he term water includes both drinkable water with respect to pollution and hydrology water modelling with respect to floods and sea level rise as a result the significance of modelling techniques especially regarding water pollution coastline management flood prediction and sea level rise assessment cannot be overstated copernicus has already tools to forecast assess and analyse such domains and also to manage forthcoming emergencies indeed jrc states that copernicus emergency management service cems is gaining a lot of traction from policy makers scientists and public bodies for managing assessing and preventing climaterelated emergencies such as floods and droughts despite this trend the potential of copernicus data and services especially for emergency and climate applications has not been fully realised by industrial and policymaking stakeholders terra realises that innovation stemming from copernicus services and data could set the basis for future collaborations accelerate ri progress and increase the eus excellence in cuttingedge technologies to this end we target the second ri area of the horizoncl42024space0135 namely the the development of an integrated harmonized and coherent product provision system to improve global scale hydrological monitoring and forecasting terra envisions the creation of several services and product chains that fuse copernicus services with stateoftheart technologies to provide solutions for coastline detection coastline erosion prediction flood risk assessment and mitigation water pollution assessment and coastline modelling he project targets the swot mission and group on earth observation objectives and provides the necessary framework to promote its outcomes through the global earth observation system of systems geoss
completing the revolution enhancing the reality the principles and the impact of economics credibility revolution

applied economists routinely evaluate the effect of economic policies for instance what is the effect of raising the minimum wage on employment angrist pischke 2010 argue that applied economics has recently experienced a credibility revolution by switching to transparent methods to evaluate policies applied economists have increased the credibility of their findings and the impact of their workin the first part of this proposal i show that the credibility revolution is not complete twoway fixed effects regression a policyevaluation method used in as many as 26 of the mosthighly cited papers recently published in the american economic review relies on the assumption that the policys effect is constant across units and over time in most applications this assumption is not credible therefore i propose a series of new differencesindifferences estimators that do not rely on this constant effect assumption and that can be used in virtually all the applications where twoway fixed effects regressions have been usedin the second part of this proposal i argue that the credibility revolutions focus on unbiased estimators may be hard to defend as variance also matters i explore two ways of tradingoff bias and variance the first amounts to combining an unbiased and a biased but potentially more efficient estimator of the same parameter the second amounts to deriving the minimax estimator of the policys effect under the assumption that this effect cannot be larger than a potentially large constant bfinally the third part investigates the potential impact of the credibility revolution specifically i will run a randomized controlled trial to measure the effect of following an online course presenting policy evaluations in two very different populations policy makers and members of the general public focusing on individuals with a low trust in institutions in that second group
biobased repairable and recyclable vitrimer composites and advanced sensors for highly reliable and sustainable wind blades

today 25 million tonnes of composite material are in use in the wind energy sector globally wind turbine blades are made up of composite materials that allow lighter and longer blades with optimised aerodynamic shape which boost the performance of wind energy however current wind blade composites exhibit relatively short life spans are problematic to repair and are notoriously difficult to recycle as we continue to build more wind farms these issues pose a major problem to achieving a truly sustainable european wind energy sectorthe eolian project will develop an innovative new smart wind turbine blade manufactured from an infinitely recyclable circular platform chemistry with inmould electronics recyclable sensors and heating actuators that detect damage early before it becomes a major issue eolian is the breakthrough that will make obsolete singleuse engineering resins in wind blade manufacture our unique blade is made using vitrimers a new class of polymer combining the performance of thermosets with the processability and logistical benefits of thermoplastics vitrimer resins enable circularly recyclable composite structures 1 and the option of postcure processing provides unprecedented manufacturing flexibility 2 but also repairability 3 these three features will provide a truly sustainable and stepchange approach in how wind turbine blades are maintained reshaped for new applications andor recycled in a circular economyin the project we will validate these performance claims through the manufacture testing and benchmarking of a smart sensorassisted vitrimerbased composite 14m prototyped wind blade additionally we will prove circular recyclability through the manufacture of 2nd generation composites with i recycled fibers and recycled vitrimer obtained after the chemical recycling by vacuum infusion ii with composite parts produced by smc sheet mould compound following mechanical recycling
right futures the liminal political timespace of the real right in chile and italy

rightfutures inquires into the ways futureoriented activities shape the political experiences of youths 1835 yo who identify with the selfdefined real right in italy and chile rightfutures research question rq asks how and why do youths who identify with the selfdefined real right in italy and chile engage with multiple futural orientations through political performances events activities and materialities rightfutures investigates the rq through three specific objectives focusing on security and defence the dictatorial past and the nation it uses the method of comparative ethnography data will be collected through participant observation extended interviews participatory mapping and secondary sources rightfutures will focus on youths who identify with groups that have inherited the countries dictatorial legacies acknowledging that the existence and practices of these groups become pivotal points used to renew the dictatorial pasts rightfulness these groups thus preserve perpetuate and renew the dictatorial pasts contemporary relevance and permanency within democratic structures its innovative contributions are i investigating the real right using a novel analytical focus through a futural temporal perspective ii proposing a novel ethnographic comparison between italy and chile to explore the global relevance of this topic and iii producing novel understandings of the real right in italy and chile
international platform on obstetric violence ipov an innovative tool for a respectful maternity and childbirth care

overmedicalisation and disrespect in maternity and childbirth care have been identified by international research as an urgent global public health topic who 2014 simonovic 2019 council of europe 2019 the ipovrespectful care project intends to bring attention to obstetric violence and respectful maternity and childbirth care by implementing a concrete toolthe international platform on obstetric violenceto bridge academic research and public policy training for health professionals womens perspectives and public engagement on the matter the platform will be an innovative international interdisciplinary intersectoral and crosscultural digital and interactive tool for producing sharing and transferring knowledge systematising and exchanging good practices acquiring skills and planning gender based innovative training packages on respectful maternity and childbirth care among health professionals health training managers decision makers researchers women and all of society to achieve these goals a network of 39 breakthrough experts from 19 participating organisations and 9 countries universities research centres civil organisations and health maternity care institutions will be established
supramolecular microcapsules for bioreactor expansion of induced pluripotent stem cells

the suprotect proofofconcept project seeks to apply our squaramidebased sq supramolecular materials to prepare microcapsules for the culture of pluripotent stem cells building on earlier demonstration of bioactive hydrogel synthesis and in vitro culture of ipscs in 3d cell culture under static conditions we will synthesize the necessary amount of material for ipsc culture studies develop protocols to prepare microcapsules with and without ipscs and evaluate the feasibility of the different microcapsules for the culture of ipscs and their release ranking the approaches on ipsc number and quality for further downstream application in parallel with these activities we will perform detailed market research studies on microfabricated polymer materials for culture of various cell types protecting our intellectual property ip position and consolidating our findings in a package for product licensing with the appropriate party
isotopic labeling of biotherapeutics

biological drugs such as peptides proteins oligonucleotides and analogs provide the patients with more efficacious and less toxic treatments and have lower attrition rates than chemical drugs since 1 on 9 new biological entities entering clinical trials reaches the market 1 on 16 for chemical drugs consequently 15 on 24 top blockbuster drugs were biotherapeutics in 2020 worldmarket share of about 40 of 175 billion of revenue per year in order to reduce the immunogenicity of biodrugs to overcome their fragility and to increase their capacity to reach quickly and massively their target reducedsize biologics are extensively developed however radiolabeling of large molecules by grafting bifunctional chelating agents which do not alter significantly their biological activity is thus no longer possible with smaller biodrugs it is therefore of paramount importance to devise new radiolabeling approaches carried out on tiny quantities in aqueous media and very soft conditions it is also crucial to train a new generation of radiochemists in order to implement these methods and to meet the needs of the european industry isobiotics ambitions 1 to develop new chemicallybenign strategies for the laststage radiolabeling of large peptides smallmediumsize proteins oligonucleotides and analogs with deuterium tritium and carbon14 preclinical and phase 0 clinical evaluation and fluorine18 phase iiii clinical trials 2 to educate a new generation of young talented phd students specialized in the radiolabeling of biologics through a combination of interdisciplinary lab research transdisciplinary and intersectorial secondments technical taught courses scientific lectures and complementary skills workshops 3 to ensure the appropriate dissemination exploitation and communication of all isobiotics outputs in order to maximize the projects impact and radiance 4 to secure the students employment and the sustainability of training structures
science for policy by european academies

science advice for policy by european academies sapea is part of the scientific advice mechanism to the european commission which provides independent scientific evidence and policy recommendations to the european institutions by request of the college of commissioners sapeas role is to provide independent highquality evidence reviews to inform policy recommendations made by the group of chief scientific advisors to achieve this sapea assembles interdisciplinary working groups of scientific experts supported by systematic literature reviewssapea is a consortium of the six european academy networks academia europaea allea easac eurocase feam yasas that bring together some 120 academies from over 40 countries across europe the academies fellows have expertise in a diverse range of fields including natural sciences engineering technology medicine and health agricultural and social sciences and humanitiessapea follows a comprehensive edi strategy incorporating experts from all relevant scientific fields of the scientific community focussing on integrating at least 10 earlycareer and 30 midcareer researchers achieving gender balance and ensuring wide geographical representation from across europesapea works to raise awareness of the sams activities and to improve the quality of public debate about the role of evidence in policy contributing to the transparency of eu policymaking sapea engages with policymakers the scientific community stakeholders and the wider public in a range of dec activities including websites social media events media relations and a range of publicationsmore information can be found on the projects website wwwscientificadviceeu
safe efficient and autonomous multimodal library of european shortsea and inland solutions

seamless aims at developing and adapting missing building blocks and enablers into a fully automated economically viable costeffective and resilient waterborne freight feeder loop service for short sea shipping sss andor inland waterways transport iwt autonomous systems will be integrated to ensure safe resilient efficient and environmentally friendly operation to shift road freight movements to hinterland waterways while enhancing the performance of the tent network the service will be delivered 247 by a fleet of autonomous cargo shuttles with humansintheloop located in remote operation centres rocs which efficiently cooperate with automated and autonomous shoreside infrastructure and safely interact with conventional systems the services will rely on a redesigned logistics system enabling seamless freight flows by minimising delays at intermodal nodes a digital birds eye view of the supply chain allows the exploitation of realtime information for planning optimisation and reconfiguration to support resilient logistics incl digitalised administrative procedures the seamless building blocks will be verified and validated by conducting fullscale demonstrations in selected realworld scenarios transferability will be fully demonstrated in selected use cases that cover a wide range of transport applications and geographical regions throughout europe based on a structured methodological framework evaluating sustainability criteria they will act as guidance for the replication of the project results beyond the project scope and timespan novel business models will be thus developed and provide a framework for implementing the seamless service to minimise investment risk for first movers regulatory gaps and challenges related to autonomous vessel operation eg social aspects will be identified and recommendations for policy makers to allow the smooth and safe deployment of fully automated services will be provided
serological testing and treatment for p vivax from a clusterrandomised trial in ethiopia and madagascar to a mobiletechnology supported intervention

p vivax is considered the most difficult human malaria to eliminate because of the inability of conventional diagnostics to detect individuals with latent liver forms these individuals account for 80 of all infections and can readily infect mosquitoes currently countries can test knowing this has little impact or and the treat everyone which exposes individuals to drugs with potentially dangerous side effects parasite specific antibody responses have been shown to correlate with the likelihood of hypnozoite carriage and can be used to identify individuals who should be treatedaim is to implement a clusterrandomised trial in ethiopia and madagascar to demonstrate the effectiveness of a new antimalaria intervention based on plasmodium vivax serological testing and treatment pvstatem with primaquine to prevent the relapse infections responsible for maintaining p vivax transmission simultaneously we will assess social and health system acceptability of such an approach as well as refine new mobile technologies which interface with pointofcare diagnostic tests and guide treatment decisionswe aim to reduce malaria burden at both the individual and population level in two countries which experience the highest levels of pvivax in africa we expect to have a significant effect in reducing morbidity and improving health we will ensure community engagement and assess the adoption of new technologies that align with those existing in the health system the proposal is built on equal partnership and shared capacity to address a substantial public health burden
skills2capabilities

the skills2capability project is about understanding how skill systems across europe can reduce the level of skills mismatch in their labour markets it is recognised that future labour markets will be more mobile with more people moving between jobs employers and sectors more often this poses a problem for training systems insofar as employers may be much less willing than in the past to fund and provide training because their chances of appropriating the return will have been reduced the study is concerned with understanding how skill systems can better respond to meeting skill demands in a more fluid labour market environment the starting point is that of considering whether there is a need to provide individuals with a wider range of capabilities to weather a greater range of labour market challenges than those faced by their counterparts from previous generations some countries have been able to use their skills systems to deliver more of these capabilities than others though the impact of this on labour market transitions is uncertain something the current study addresses if skills systems are to confer skills on individuals which provide them with increased resilience and capability then there is a need to know what those capabilities or skills are in practice the research addresses this from both a demand side what are the skills which are currently in demand and are likely to be so in the future and a supply side to what extent are these capabilities reflected in vet programmes perspective the research will provide decision makers in government and education authorities with information which allows them to obtain a better understanding of how emerging skill needs which meet the needs of both economy and society can be met essentially providing a methodology and a tool along with detailed information about the content of those emerging skill needs and capabilities ie detailed data on demand and supply
remora small fishes in a big pond

the growing innovation divide across the european union appears particularly detrimental to small and emerging regional research and innovation systems like the outermost regions with limited resources these regions struggle to reach the critical mass needed to build comparative advantages and become knowledge societies though the european research area and the framework programmes could compensate this marginalization through greater knowledge circulation resources sharing and talents mobilities the outermost regions present a limited participation in fp7 and horizon 2020 this underutilization notably stems from the competing relations between structural funds esif and the framework programs or substitution effect many organizations and individuals prioritize easily accessible esif decide not to apply to the fp and end up in substitution trap which isolates them from promising collaborations to move outermost regions ri organizations and systems from substitution to synergies remora ambitions to transform 3 ocean and marine esiffunded institutions in la runion madeira and the azores into horizon europe champions citeb okeanos and oom to that end remora will enhance their competitiveness notably human resources knowledge transfer and innovation capacities strategic positioning and connections with major eu networks through a joint internationalization strategy remora will then use the successful transformation of these 3 role models to lead other esiforiented ri organizations and policymakers in outermost and widening regions on the path to synergies