Dragon09/odtu_chatbot huggingface dataset:
sustainable bioinspired wax coating for multifunctional crop protection

according to the fao plant diseases cost the global economy around 210 billion per year and fungal pathogens destroy at least a third of all food crops annually commercial agriculture relies on chemical fungicides for crop protection owing to their easy application and low cost however their overuse and misuse have devastating implications for all living systems and the entire ecosystem thus establishing sustainable crop protection strategies is essential for global economic development environmental protection and food securityinspired by superhydrophobic plants such as lotus and broccoli which exhibit wax crystals on their cuticles we propose a generic sustainable strategy for passive crop protection against fungal pathogens our biomimetic technology termed safewax relies on bioderived nontoxic fatty acidbased sprayable formulations which selfassemble into a multifaceted protective coating with antiadhesive selfcleaning and antifungal properties when applied on sensitive crops which do not naturally exhibit wax crystals safewax will synthetically render their foliage to passively resist pathogens safewax concepts will initially be demonstrated on grapevine as a relevant model crop of high importance to europes economy environment and culture which is highly susceptible to fungal diseases and is the mostfrequently treated crop safewax will then be expanded to other sensitive commodity crops the biodegradable safewax coating will not only protect crops from fungal infections but will also be tuned to provide uv radiation filtering prevent sun damage as well as facilitate water collection from dew condensation mitigating inevitable effects of climate changesafewax will revolutionize the global fungicides market valued 20 billion starting from the biofungicide market with a value of 32 billion by 2025
from single molecules to cell reprogramming deciphering and recoding disordered pioneer transcription factors

pioneer transcription factors ptfs have unique capabilities beyond classical tfs they can invade and open closed chromatin initiating cellfate changes their remarkable abilities have been used to steer cellfate decisions and to induce a pluripotent stem cell state through poorly understood pathways like most tfs ptfs consist of structured dnabinding domains dbds flanked by long intrinsically disordered regions idrs in attempts to explain their pioneering functions intense focus has been on how the structured dbds of ptfs interact with the nucleosome core particle yet the critical interactions with nucleosomes beyond the core particle the interplay between dbds and idrs and the molecular mechanism of chromatin invading and opening remain unclearthe extensive disorder of ptfs places them outside the scope of current structural biology efforts and understanding their functions therefore requires a different approach singlemolecule spectroscopy offers a powerful toolbox to monitor dynamic molecular systems and measure their conformational distributions these methods enable quantitative modeling of distances and dynamics in biomolecules over timescales reaching over 15 orders of magnitude building on our recent breakthroughs in singlemolecule techniques for studying highly disordered proteins in chromatin regulation and our preliminary data on ptf idrs we are in a unique position to apply our expertise to the molecular mechanism of ptfs using five established ptfs involved in four distinct cell reprogramming pathways we intend to 1 map conformational states 2 decipher kinetic mechanisms 3 engineer new ptfs and 4 observe chromatin remodelling both in vitro and within the complex cellular environment a molecularlevel understanding of ptf functions may break the barrier to fully controlling cell fate unleashing the enormous medical potential of cellbased therapy
bringing excellence to transformative socially engaged research in life sciences through integrated digital centers

the project bringing excellence to transformative engaged research in life sciences through integrated digital centres better life will establish a european digital centre of excellence for fostering socially engaged research ser in life sciences as well as seven regional centres operating in their surrounding ecosystems this interinstitutional support structure addresses the lack of collaboration between early career researchers and the nonacademic sectors by designing tools standards and framework conditions under the umbrella of the eu centre and implementing these solutions in the regional ecosystems the project aims to support the development of interinstitutional capacities by establishing an eu better life coordination centre that will generate transferable tools and standards at an intrainstitutional level the project creates local centres guided by a framework to follow the regional customization implementation at an individual level the regional centres develop capacities by training early career researchers and establishing a community of practice in each surrounding ecosystem for that purpose the centre is based on the quadruple helix model of innovation where the interaction of academic research industry government and society generate mutually beneficial partnershipsthe most outstanding outcomes of the project will be200 early career researchers trained14 engagement managers trainedat least 10 standards for ser in life sciences14 consultation events with local stakeholders40 open source documents6 open science publications1 digital selfassessment tool for researchers15 training eventsin a long term the project will generate scientific impacts by designing transferable policies and tools economic impacts by effectively attracting funding and societal impacts by embedding local ecosystem needs and enhancing the reallife impact of academic institutions
bioexcel centre of excellence for computational biomolecular research

life science is turning into a datadriven and hpc dependent research field bioteamhyperions 2022 estimates show that 95 of life science projects are being dependent on hpc the rapid response to covid19 showed how an eu collaboration between pharma industry life science researchers and supercomputing centres resulted in several newly identified hits now undergoing clinical trials life science is already delivering actual drug candidates within a year by using hpc in general and bioexcel codes in particular 1000s of papers citing gromacs or haddock for sarscov2 simulations the centre of excellence for computational biomolecular research bioexcel was established in 2015 and funded again in 2018 to help accelerate this development the bioexcel3 strategy to achieve significant impact relies on i ensuring that the most widely used european codes provide high performance efficiency scaling reliability and quality to meet academic and industrial needs ii identifying user needs to prioritise development of features with high scientific impact performanceporting requests for deployment on eurohpc resources iii providing stateoftheart training program for nextgeneration eu workforce on exploitation of ensemble algorithms ai approaches and convergence of hpc htc and hpda iv being the preferred eu partner for international organisations v providing sustainable business paths for companies that need commercial support or want to fund development of specific features and vi operating under an open governance model that provides transparency for the community and ec to be confident bioexcel makes the right priorities based on user and hpc needsbioexcel3 will grow and sustain the life science hpc community in europe our success will be measured by our ability to support codes and train scientists who produce almost 10000 scientific papers and numerous industrial projects every year
the interplay of aging immune signaling and stem cell function

adult stem cells scs sustain tissue renewal and repair throughout life the sc niche is fundamental in the regulation of sc function and an important contributor to sc decline in aging while alterations in the tissues immune environment are emerging as important contributors to impairments found in aged organs their contribution to sc dysfunction in aging is unknown the skeletal muscle skm is a paradigmatic model to study agerelated loss of repair capacity muscle stem cell musc function during regeneration requires plasticity in transit between states of quiescence activation and differentiation musc functional impairments in aging result from changes in the extrinsic cues that govern their behavior but also cell intrinsic alterations including senescence and defects in lineage commitment however we still have a limited understanding of how changes in the environment manifest as sc intrinsic defectsour previous work indicates that changes in immune signaling are important drivers of musc dysfunction and regenerative decline in aging here we propose to identify the contribution of specific immune populations and signals to changes in regenerative capacity and musc activity in aging aim 1 we hypothesize that the immune environment is an essential regulator of musc plasticity and lineage commitment under regenerative pressure and immune alterations underlie defects in musc lineage fidelity in aging we propose to map the trajectories of muscs diverging from the myogenic lineage and uncover the changes in epigenetic landscape that underlie the loss of lineage fidelity associated with immune aging identifying transcriptional regulators of musc fate aim 2 the knowledge generated on the mechanisms linking immune aging and musc dysfunction will be tested for the conservation in human skm and will be applied to improve the success of muscbased therapies in aging aim 3
midinfrared quantum technology for sensing

to increase our ability to sense the changes in the environment around us we must understand how to control the quantum properties of light and matter at the fundamental limits of their interaction as such quantum sensing is poised to bring paradigmshifting transformations to how precision measurements are performed given the central role that mir spectroscopy plays on many of the pressing issues facing modern society there is an urgent need for systematic investments into the innovation and development of mir quantum technologies for sensing applications miraqls brings together an interdisciplinary team of canadian and european researchers together with industry partners who share a longterm vision for the development of mir quantum photonic technologies for sensing applications our team combines expertise in quantum photonics materials science optoelectronic component development mir laser science and spectroscopy biophotonics photonic inverse design quantum optics theory and quantum information science and quantum technologies miraqls aims to tackle some of the biggest challenges that have hampered the development of mir quantum technologies while at the same time delivering concept demonstrators such as quantumenhanced fouriertransform infrared spectrometer qftir quantumenhanced optical coherence tomography qoct and su11 interferometry by manipulation of quantum statistics of the input states eg squeezing and entanglement operations we aim to achieve better sensitivity bounds in comparison to the classical technology limited to the operation at the standard quantum limit sql improvements in mir sensing will directly translate to increased societal wellbeing safety and prosperity it becomes indispensable in the context of the global fight against the looming climate crisis
tunable topological chirality in ferroelectric nanomaterials

chirality is one of the most intriguing fundamental phenomena in nature materials composed of chiral molecules find broad applications in areas ranging from nonlinear optics and spintronics to biology and pharmaceuticals however chirality is usually an invariable inherent property of a given material that cannot be easily changed at will very recently we discovered that chiral structure emerges as a basic configuration of polarization field in ferroelectric nanoparticles and nanodots in a form of stable fundamental topological excitations of polarization hopfions and skyrmions and importantly can be controlled and switched by cleverly devised fieldtemperature protocolsthe key idea of the project is to reveal how this discovered emerging topological chirality will be identified measured explored and put in practice using the unique facilities and excellence of jozef stefan institute in slovenia accordingly the research objectives of the ferrochiral msca are defined as follows to optimize fabrication parameters enabling the engineering of ferroelectric nanostructures with desirable chiral properties to develop research approaches for revealing and exploring the topological structures of the ferroelectric nanostructures to devise efficient enantioselective procedures and elaborate effective methods for chirality revealing and operationthe new skills in nanomaterial fabrication and operation and in building the academiaindustry links will be developed for further career pursuit also the project will cluster the ferrochiral action with the complimentary european networks in view of prospective developing longlasting collaborations
developing new 2d materials and heterostructures for printed digital devices

2dprintable aims at using sustainable liquid exfoliation methods to make 40 new 2dmaterials 2dms and to develop printing and liquiddeposition methods to fabricate nanosheet ns networks and heterostructures with unique properties to enable the production of advanced printed digital devices in perfect alignment with the expected outcomes of the work program to identify new 2dms we will use modelling to survey thousands of possible 2dms to identify those with superlative electronic properties conductors semiconductors insulators layered crystals of these target materials will be synthesized and converted to nss using various liquid exfoliation techniques chemical functionalization will be used to modify and tune ns properties and to achieve insitu chemical cross linking we will develop a range of printing and deposition methods to produce ns networks employing both physical and chemical routes for strong coupling between adjacent nss leading to extremely low junction resistance and hence exceptional network mobility going further we will printdeposit networks of different nss on top of each other leading to heterostructures with stronglycoupled interfaces for efficient charge injection and transfer these will be the basis for a range of printed electronic devices transistors solar cells or leds with very high performance because of the superlative nanosheet properties the quality of interfaces and the facile nature of internanosheet charge transfer for example we expect to produce printed transistors with gate capacitance 04 mfcm2 transconductance 01 mssq ionioff ratio 10e6 mobility 100 cm2vs with the latter value x10100 times greater than the stateoftheart in printed electronics the knowledge developed in 2dprintable will be instrumental for future emerging technologies in energy storage health and environmental monitoring as well as water purification to ultimately address most of todays global challenges
data loss the politics of disappearance destruction and dispossession in digital societies

the objective of data loss the politics of disappearance destruction dispossession in digital societies daloss is to empirically demonstrate data loss as an integral dynamic within the current turn to digitization and big data with deepseated societal and political implications for the ongoing development of digital information ecologies daloss examines data loss across three archival regimes the internet european bureaucracies and social media platforms it provides the first systematic study of data loss offering novel and important insights for the future of european data politicsthis project employs an original methodology combining ethnographic and digital methods including digital forensics counterarchiving and linkrot scoping on this basis daloss pioneers a new interdisciplinary approach which brings together different tracks of theory within critical data studies and critical archival studies this approach enables distinct but mutually interconnected dynamics of data loss disappearance destruction and dispossession to be studied within a common analyticaltheoretical framework the analysis will offer unique insights into data loss as part of ongoing digitization and datafication processes and the political social and infrastructural implications of this phenomenonthe breakthrough potential of daloss is twofold by shifting the focus in big data discourses from accumulation to loss this project establishes an entirely new and societally important research agenda of general relevance to scholars working on big data within the humanities and social sciences second by situating data loss within the broader intellectual histories of loss and technology the project develops a theoretical apparatus for understanding data loss not merely as technical challenges but also as a fundamental cultural and political condition
integrating a palliative care approach for patients with heart failure

while the need for integrating palliative care pc services into heart failure hf care has been well recognised as of yet this integration lacks behind especially when compared to cancer care currently only 57 of patients with hf utilise pc services due to a focus on optimising therapy and an unpredictable disease trajectory with exacerbations which hampers prognosis as a result many symptoms and concerns that are not directly related to hf are not recognised and undertreated and patients are often referred to pc services only at the very end of their lives the raphael consortium sets out to take the next big step in integrating pc into hf care by integrating the raphael palliative care approach in existing hf care pathways this flexible and patient centred approach starts with the identification of multidimensional symptoms and concerns prioritise needs with patient and informal carer and formulate a proactive care plan the symptoms and concerns will be monitored by the patient at home using the palheart application the app can be used to evaluate interventions support communication and earl identify new or increasing needs as a result the care needs of each individual patient with hf are addressed faster and better improving their quality of life and autonomy moreover this will lead to a reduction in emergency hospitalisations unburdening the healthcare system and reducing costs the raphael project sets out to adapt the raphael approach to hf care within a european context and test and validate its costeffectiveness via a feasibility and largescale evaluation study performed in 7 eu countries the uk and switzerland it brings together experts in palliative care cardiology and primary care as well as professional organisations and patient representatives together the raphael consortium is uniquely situated to demonstrate the costeffectiveness of the rapahel approach and launch its implementation in europe and beyond
explaining common envelope evolution and dynamics in binary stellar systems

a thorough understanding of stellar evolution is key to nearly any branch of astrophysics the majority of stars evolves in binary or multiple systems and interactions often occur between their components such dynamical interaction phases are pivotal for the fate of the system and its constituents but they elude classical stellar modeling commonenvelope phases in which a compact companion spirals into the envelope of a giant primary star are the glaring gaps in our knowledge and pose one of the last unsolved fundamental problems to stellar astrophysicsthe exceed project breaks new ground by developing a strategy to reach a comprehensive understanding of commonenvelope evolution it combines leading threedimensional magnetohydrodynamic movingmesh simulations with innovative models of physical processes to decipher the dynamical interaction between the stellar cores and the envelope material on this basis the postcommon envelope evolution is explored by consistently linking to classical onedimensional models predictions for astronomical observables are derived and a faithful effective prescription for representing commonenvelope phases in binary stellar evolution and population synthesis calculations is constructedthe new understanding of commonenvelope evolution provided by the exceed project marks a break through in stellar astrophysics and has implications beyond this field exceed finally settles the long standing questions of the mechanism of envelope ejection and the orbital separation of the postcommon envelope remnant binary system this allows to understand the formation of the targets of gravitational wave astronomy that holds promise to solve problems of fundamental physics the progenitors of type ia supernovae and many other astrophysical events
teaming conductivity and chemical functionality in metalorganic frameworks for zincion batteries

zincion batteries zibs are among the most promising electrochemical energy storage ees technologies that could meet the future demand for green and safe storage of electric power which is vital for a low carbon and fossilfuel independent civilization however the low cost earthabundance and superior safetystability of zinc zn in comparison to lithiumion batteries comes with formidable challenges such as slow zinc ion migration and dendrite growth limiting their chargingdischarging time and lifespan recent advances have expanded the design toolbox of metal organic frameworks mofs and of tailored graphene derivatives the core expertise of the applicant and of the host institution respectively which could drive the developments towards the next generation of zibs the zion project comes to meet the fundamental need for decarbonisation enabling safe sustainable and lowcost batteries via the exploration of 3d and 2d conductive mofs cmofs and hybrids thereof with tailored graphene derivatives as hosts for zn which have so far remained largely unexplored in zibs the conductivity and open framework of these materials in comparison to the present insulating and low porosity cathodes can boost zn ion migration functionalization of both materials with chemical groups suitable for zn coordination can streamline a homogeneous and dendritefree deposition of metallic zn at the anode through directed nucleation in their frameworks and at coordination sites importantly tailored graphene derivatives with dense outofplane functionalities can facilitate the formation of covalent hybrids with cmofs ascribing hierarchical porosity and conductive bridges between the cmof particles or sheets the zion project will thus offer indispensable knowledge for the advancement of lowcost sustainable and safe zibs which also offer one of the highest volumetric energy densities necessary for storing a lot of energy in smallsized batteries