Dragon09/odtu_chatbot huggingface dataset:
ngi platform for coordinated euus open calls for networking research and innovation

ngi transoceanic builds on the success of the precursor initiative ngiatlanticeu 20202023 delivered by the same eu partners and two usa partners as a strong and consolidated european union eu and united states of america usa financial support to third party fstp ecosystem with 35 funded eu usa projects on ngi topicsthe main ambitions of ngi transoceanic are the following1comprehensive team approach on involving the key stakeholders from eu and usa in the consortium and already established and expanding eu usa twinning lab capitalising on their track record complementarity and networking potential2having an eu usa joint calls approach between the eu ngi programme and nsf internet programmes3implementation of three dedicated longer term 18 months open call cycles to be delivered over the 48 months of the project covering expansive ngi topics with 3200000 in fstp funding earmarked4this will be delivered through three different project modalities including projects for advanced technology development joint demonstrators and joint contributions to standards covering the priority topics of trust and privacy enhancing technologies data sharing and portability sustainable and climate friendly internet electronic identities internet architecture renovation and decentralised technologiesngi transoceanic has four objectives which map well with its workplan o1 eu usa next generation internet ngi landscape frameworko2 realise eu usa open calls and provide financial support to thirdparty projectso3 twinning activities and support services for the eu usa stakeholderso4 to ensure maximum impact and sustainability of the eu usa ngi activities and to promote the standardisation and industrial application of the ngi transoceanic results
development of advanced bioglasspolymer scaffolds for osteochondral interface tissue regeneration

damage to the osteochondral interface oci is a serious health problem associated with the development of osteoarthritis affecting the lives of millions of people however current treatment tools have imitations leading to unsatisfactory clinical outcomes this project aims to solve the problem by a complex approach combining and advancing recent findings in the field of tissue engineering te it is accepted that patient cells can be seeded onto artificial scaffolds containing biologically active substances bass to stimulate these cells to new tissue formation we take the view that the scaffold should consist of a soft part and a sufficiently stiff part to avoid the formation of unwanted fibrocartilage we will use cryogelation and 3dprinted bioactive glass to prepare multiphasic scaffolds that can carry regulatory signals for adiposederived stem cells adscs our research objectives are to develop 1 a stiff scaffold with a graded structure matching the morphology of the subchondral bone and able to be loaded by bass to facilitate osteogenesis 2 a soft scaffold based on a cryogel enriched by bass to facilitate chondrogenesis and 3 a combined scaffold matching the zonal structure of oci to enhance its regeneration 4 we will use adscs and modern ex vivo testing protocols to evaluate the potential of the scaffold to meet the needs of oci te and to direct future research to in vivo testing and commercialization the research will be conducted within the academic structures of the university of chemistry and technology uct in prague czech republic in collaboration with the biotechnology and biomedicine center in vestec biocev near prague under the supervision of prof jan merna and prof bacakova
vectors to accessible critical raw material resources in sedimentary basins

the eu imports 80 of its industrial raw materials making european supply chains highly vulnerable to disruption and threatening the eus ability to manufacture raw materialintensive technologies such as electric cars wind turbines and ict hardware that are essential to the green and digital transformations europe possesses significant mineral potential but development is limited by the lack of sustainable lowimpact exploration methods and by social opposition to mineral projects with vector we will generate new knowledge to overcome these technical and social barriers unlocking europes raw material potential and improving the resilience of eu raw materials supply chains overcoming issues will require major changes of the business models in the extractives industry and to integrate a more humancentred approach the vector project is based on the premise that a prerequisite to any sustainable human activity is to minimize the environmental and social costs and include all the stakeholders in the decision making processes around this vectors overall objective is to deliver evidencebased and accessible knowledge that integrates the scientific and social pathways to successful mineral exploration and mining the first pillar of our approach is a geological prospectivity toolkit based on an entirely new workflow using machine learningbased integration of less invasive geological geochemical and geophysical measurements the workflow will be validated in three european sedimentary basins and will be transferable worldwide the second pillar is a social acceptance procedure that identifies for the first time the values that the european public invokes when deciding about mineral development this will result in a social acceptance index and a new body of knowledge that reflects diverse valuesbased perspectives the third pillar is an integrated toolkit consisting of a unique distributed multimodal selflearning and interactive platform that will consider both geological exploration potential and socioeconomic factors to yield a datadriven quantitative and integrative assessment of regions more suitable for exploration and eventually mining the results will be freely available via an engaging webbased interface designed to support evidencebased decision making and the unfc and unrms
open superconducting quantum computers opensuperqplus

opensuperqplus100 aims at delivering systems and technology for quantum computers based on superconductors it thus implements the roadmap of the strategic research agenda for the quantum technology flagship as detailed by the opensuperqplus framework partnership from which it emerges it will deliver integrated demonstrators for research and user purposes one of which will contain at least 100 highquality qubits the center piece is a design and fabrication platform for highquality quantum chips their environment for multichipmodules and the immediate surroundings of the processors opensuperqplus100 delivers the necessary components and the enabling hard and software to achieve that goal this is completed by a test and benchmarking suite exploring the potential realization of beyondclassical performance in realworld applications the agenda of opensuperqplus100 is looking ahead in developing testing and downselecting technologies that are needed to reach the 1000 qubit level in a subsequent project the composition of the project with leading companies rtos and academic groups is closely aligned with national agendas which lay the foundation for the opensuperqplus100 results the project contains structured activities in standardization education and ethics that will inform larger european discussions opensuperqplus develops structured ip policies and commercialization strategies of its key exploitable results and will serve as a reliable source of information for european stakeholders in industry academia politics and society at large
demonstration of sonication and microwave processing of essential chemicals

simplidemo the demonstration of sonication and microwave processing of essential chemicals project aims at strengthening the chemical process industry and in particular the specialty chemicals and pharmaceuticals industries in its capacity to produce materials and chemicals in a sustainable and competitive way by moving from batch to continuous and modular production with flexibility being ensured by the application of alternative energy forms currently the conventional technologies in the specialty and pharma sector tend to be batchtype combined with mechanical mixing and conductionbased heat transfer inherently leading to poor process control simplidemos vision is that of intensified processes where alternative energy sources enable continuous and modular technologies to achieve localized actuation of multiphase flow reactors for the purpose of highvalue product synthesis simplidemo focuses on the synthesis of specialty polymers and particles for use in a wide variety of everydayuse products eg insulation paints and coatings plastics catalysts as well as health applications which are important domains in the chemical industry today and into the future therefore simplidemo advances the technology readiness level trl of modular flow technology for multiphase streams involving suspensions or viscous products from trl5 validation in relevant environment to trl7 industrial system demonstrationsimplidemo has brought together a consortium of four enduser chemical companies two technology suppliers ultrasound and microwave technology five universities and research institutions process control automation reactive extrusion oscillatory flow ultrasound microwaves one sme experienced in modular automation and another sme experienced in sustainability assessment and exploitation
the delft laminar hump a novel local surface geometry for passive laminarization of aircraft wings

the exponential growth in aviation calls for radical new technologies to curb aircraft fuel consumption and emissions at the heart of the problem lies aerodynamic drag laminarization namely the extension of laminar flow over the wing holds immense potential for reducing aerodynamic drag by up to 15 unfortunately many solutions proposed so far are costly complex and unreliable thus obstructing laminarization from reaching industrialscale applicationthe delft laminar hump aims at breakthrough efficient robust and effective laminarization of aircraft wings the hump is a fully passive localised geometry modification of the wing surface discovered by the pi and his team through their research on laminar flow control in their preliminary experiments the team has demonstrated a significant laminarization effect and have recently proceeded with an initial patent application delah aspires to be the first step in transitioning the hump concept from laboratory to innovation and societal impact technical activities are planned towards validating the concept in wind tunnel tests at conditions resembling cruise flight and documenting the influence of reallife environmental factors such as roughness innovation activities cover a diverse range of objectives such as the strengthening and extension of ipr and the definition of a technology transfer strategy from hi to key industrial stakeholders such as airbus a market and feasibility analysis will be combined with a business development plan to explore and exploit industrial and research collaborationsthe pi and team will work closely with a group of stakeholders within the hi such as the impact and innovation centre providing expertise in ipr and business development and the aerospace innovation hub providing an engaging platform to industrial partners ultimately the project will strive to position the hump technology at the starting line of technological development and industrial adoption
european science in the city and euroscience open forum katowice 2024

the project aims to build a real city of science in which 1 science becomes the foundation for the method of managing and creating changes2 research work is seriously taken into consideration in the processes designed to implement changes 3 science is an element and the driving force of transformation intended to improve the quality of life 4 universities are a public good this four missions will be implemented in katowice by the end of 2024 together by the city of katowice and the the academic consortium katowice city of science consisting of karol szymanowski academy of music in katowice academy of fine arts and design in katowice jerzy kukuczka academy of physical education university of economics in katowice silesian university of technology medical university of silesia in katowice and university of silesia in katowice leader of the consortium the direct goal is to use science and higher education as a tool for transformation of the the city and region in order to improve the quality of life for the inhabitants and to ensure dynamic development thorought the region of silesia we do not see the european city of science 2024 title as an end in itself but as a key step towards building katowice as a real city of science an agile networked science centre operating across the whole of the city celebrations of the european city of science 2024 provide an excellent opportunity to disseminate the city of science concept using this event as a base to create a real legacy project for the city itself and for all of silesia we are opening up our universities to create a worldclass programme of societal engagement with science technology and innovation we are transforming katowice into a citywide science centre generating unique possibilities and reinforcing competencies for the future of silesia poland and europe
what doesnt kill you primed and adaptive mechanisms of treatment resistance in ovarian cancer

cancer therapy resistance is a complex dynamic process preexisting heterogeneity in cell states provides substance for evolutionary selection and their plasticity enables adaptation during the therapy recently we discovered a stressrelated immunocompromised cell state underpinning both intrinsic and adaptive resistance in highgrade serous ovarian cancer hgsc metastatic tumours suggesting that preexisting stress improves the resilience of cancer cells during neoadjuvant chemotherapyto unveil how past stress responses prime cancer cells adaptation during therapies i suggest a novel approach that combines dynamic stress recording with the identification of preexisting resistant states via my novel methodology resistrace we will apply this groundbreaking approach in patientderived organoids to reveal how past stress signalling of a single cell is reflected in its adaptive stress responses and survival upon chemotherapy or cytotoxic immune attack we will further characterise subclonal and spatial enrichment of the identified resistant phenotypes in longitudinal clinical specimens to incorporate the effect of tumour microenvironment in discovered mechanismsimportantly simultaneous characterisation of primed and adaptive resistance enables us to overcome both of them by a sequential combination of drugs where the first will drive cells to identified sensitive states prior the treatment and the second will block identified adaptive responses during the treatment after finding the most effective presensitisers and antiadaptive drugs in the organoids we will validate most promising combinations in patientderived xenograft models to pave the way for clinical translation by targeting both preexisting cell states and their plasticity my novel approach will lead to a paradigm shift by providing novel sequential therapeutic strategies to mutually overcome intrinsic and adaptive resistance in the treatment of cancer
deliberative improvement of oral care quality

oral diseases and conditions affect more than 35 billion people worldwide they are the 3rd most expensive diseases to treat in the eu and disproportionally affect vulnerable groups in deviation from the un and who goal of universal health coverage many eu citizens do not have access to quality oral care without financial hardship to this end the deliver deliberative improvement of oral care quality project aims to enhance the quality of oral care through deliberative dialogue and action involving citizens patients providers payers and policymakers deliver will create a synergistic problemsolving ecosystem to convert deliberative dialogues into meaningful improvement of oral care quality deliver brings together top investigators from prestigious universities civil society and patient organizations health professionals policymakers and smeindustry to achieve a step change in collective problem solving given the comprehensiveness of the topic deliver uses a targeted approach that is entirely focused on five major rootcauses underlying the current limitations of oral care systems using a mixedmethods research approach deliver will codevelop and coproduce new quality improvement approaches in three phases the 1st phase involves situational analysis consenting of core quality indicators and development of a euwide monitoring framework the 2nd phase involves indepth analysis of select quality improvement approaches i promspremsbased quality improvement in dental practices ii communitybased quality improvement for vulnerable groups iii qualityoriented commissioning of oral health services the regulatory determinants of oral care quality improvement will be scrutinized in the 3rd and final phase the knowledge gained in the 1st and 2nd phases will be merged into the deliver quality toolkit with manuals and digital tools for concretely actionable and contextadaptive approaches for oral care quality improvement
a novel approach to improved navigation performance through memory triggering maps

as people become more mobile navigation systems in cars or mobile phones are playing an increasingly important role in spatial orientation and navigation however the cognitive map created in the users mind when using such navigation devices is much more fragmented incomplete and inaccurate compared to the mental model of space created when reading a conventional printed map as users become more dependent on digital devices that reduce orientation skills there is an urgent need to develop more efficient navigation systems that promote orientation skills in order to improve the performance of navigation systems the proposed project aims to develop the theoretical framework for mapbased interfaces that primarily take internal brain capacities into account instead of the usual landmark recognition to meet this challenge i suggest a new cartographic concept based on recent neuroscientific findings that link spatially tuned brain cells to navigation processes namely the firing activities of grid cells can be influenced by environmental cues such as walls or boundaries based on this mechanism i hypothesise that grid cell activities in the brain can be stabilised through map elements linking mapbased navigation with neural mechanisms that play a crucial role in human orientation could thus significantly accelerate the construction of spatial mental representations this research will develop a new approach to improving navigation performance by conducting a series of empirical studies using functional magnetic resonance imaging fmri electroencephalographic eeg measurements virtual reality vr and behavioural studies eye tracking if successful the proposed research could transform our understanding of navigation and map reading processes the impact on human orientation ability can be enormous as the project results could be applicable to the whole spectrum of cartographic visualisations eg in cars airplanes or mobile devices
southern european entrepreneurship engine

s3e project ambition is to develop an engine of growth that will contribute to improve the connectedness and efficiency of the southern european countries innovation ecosystems s3e focus is on the acceleration of deep tech projects startups that by providing solutions to a more sustainable society can impact the economic growth in these countries and contribute for the timely achievement of the united nations sustainable development goalsthe focus on southern european countries relates to the fact that all these countries are moderate or emerging innovators according to european innovation scoreboard 2021 and thus s3e will contribute to close the innovation gap between the targeted countries and more advanced innovation ecosystems to achieve this we will design and deliver a set of services that i support the uncovering of research projects with market potential helping them develop into deep tech startups and supporting them to procure funding for the early stages of development ii help growth stage startups to develop investment ready business plans and procure vc funding in the broader vc ecosystem or in national or european funding agencies and iii help scaling startups connect to larger companies to gain market traction throughout europe our strategic objective is supported by the following subobjectives iuncover entrepreneurial research teams with groundbreaking science and support them to commercialize the technology through the development of a startup iii increase the connectedness among members of deeptech startup ecosystems and their startups regardless of their stage of development and to the european business ecosystem seeking maximum synergies iii stimulate investments in sectors addressing sustainability issues through increasing the number of crossborder investments and empower accelerators in the targeted countries with the skills and processes that will ensure the future sustainability of the project
aragons regional hub for circularity demonstration of local industrialurban symbiosis initiatives

solid urban waste suw is an abundant source for circular products production but it is generally not exploited in fact over 500 kg of municipal waste per capita were generated in the eu in 2020 while only 45 was recycled the proximity of resources and people a sufficient scale for effective markets and the ability to shape urban planning and policy are key factors for cities to achieve advancements in this area redol has been conceived to take advantage of this scenario and transform cities into hubs for circularity that implement zero residues strategies while fostering industrialurban symbiosis ius approaches among local and regional actorsto this end redol will redesign 5 value chains for suw packaging plastics cdw textiles weee endingup in the production of 12 circular products along the value chains a range of new solutions will be implemented for 1 upgrading management technologies to collect sort and classify suw 2 enhancing the processing routes of sorted materials to avoid landfilling and 3 applying cuttingedge digital tools to optimize value chains and interaction among key players moreover redol will provide the required organizational procedures business models and social innovation actions required for the establishment of successful ius interactions and hubs for circularity at local level such an approach will result in the development of guidelines and recommendations for major decisionmaking bodies and will achieve improved citizens perception on suw as a local resource and on recycled products thus increasing their participation in separate collection schemesredol will be implemented in aragon with zaragoza in the center of the hub for circularity this way redol will support its transition towards a zero residues city by 2040 this will imply 144720 tons suwyear being reused valorized or transformed into secondary raw materials leveraging economic and ghg emissions savings over 14b and 280 ktco2year