Dragon09/odtu_chatbot huggingface dataset:
specific grant agreement n2 to scale the cities mission platform

the european commissions mission for 100 climateneutral and smart cities by 2030 the cities mission seeks to accelerate europes climate action commitments as part of the european green deal whose ambition is to make europe the first climateneutral continent by 2050 the cities missions central tenet is to elevate and deepen the commitment to pursue systemic change through research and innovation setting an ambition for cities of unprecedented scope and scale in order to achieve such effects a demanddriven mission platform has been established to provide tailored assistance and services to participating cities and those learning from them as a part of the horizon 2020 work programme building a lowcarbon climate resilient future green deal call the lcgd 122020 towards climateneutral and socially innovative cities topic selected the fouryear project netzerocities to establish the mission platform which began work at the same time as the formal establishment of the cities mission in october 2021 the scope of work presented herein will comprise the second specific grant agreement sga2nzc development under the framework partnership agreement fpanzc for the mission platform to scale and continue operations through 2027 activities primarily focus on two objectives the first to reinforce the support received by cities selected to participate in the mission on financing their roadmap of activities towards climate neutrality and the second to develop basic mission platform services for cities who are willing to commit to climate neutrality on a longer timescale than the cities mission
deciphering the role of the bloodbrain barrier in uremic toxinsinduced neuropathies

chronic kidney disease ckd is estimated to affect more than 840 million people worldwide constituting a major global health crisis clinically the number of ckd patients will continue to rise mostly because of the ageing population and the increased prevalence of comorbidities such as diabetes and hypertension in europe around 100000 million people are affected by it according to the gloomy predictions europe is at risk of a dismal increase of ckd patients as well as costs to healthcare systems patients with advanced ckd display a loss of kidney function leading to a blood accumulation of ao proteinbound uremic toxins pbuts that are poorly eliminated by renal replacement therapies this systemic retention known as the uremic syndrome affects other organs indeed neurologic complications such as bloodbrain barrier bbb disruption have been reported in ckd patients the bbb guarantees the exchange between the blood and the brain through a complex cellular organization and a diverse range of transport proteins mediates the movement of endoexogenous compounds i hypothesize that impairment of kidney tubular functionality in ckd causes an alteration of bbb integrity and function this results in an aberrant bbb passthrough of pbuts as well as impacts bbb vectorial transport capabilities this fellowship aims to develop an appropriate multiorgansonchip device to accurately describe i the impact of pbuts on bbb integrity and functionality and ii the involvement of kidneybrain axis dysfunction in pbutsdriven bbb disruption we will develop a bioprintingbased microfluidic bbbonchip to accurately study bbb permeability architecture and transport function this device will be connected to our established proximal tubuleonchip to form a robust kidneybrain multiorgansonchip system this project will pave the way toward the establishment of new and effective ckd therapies and an expert system for pharmacology studies in a near future
ndimensional analysis and memorisation ecosystem for building cathedrals of knowledge in heritage science

the research on cultural heritage makes the confrontation between material objects and multidisciplinary studies the arena for the production of collective knowledge in the digital age this is then a privileged framework for studying the collective analysis and interpretation of facts objects and phenomena that bring together a new generation of data towards the construction of new scientific resources our tomorrows heritage how can one memorise these bundles of individual gazes converging on the same object of study how can one analyse their dynamics of construction of overlap and of fusion leading to new knowledge this project introduces a new field a territory of multidisciplinary and multidimensional digitally born data as raw material for studying the mechanisms of knowledge production in cultural heritage introducing a pioneering approach in computational modelling and digitisation this project benefits from the exceptional experimental framework of the scientific worksite on notredame de paris involving today 175 researchers coming from disciplines like archaeology anthropology architecture history chemistry physics and computer scientist to build an emblematic corpus of data on scientific practices in heritage science in the digital age within this unique opportunity to produce and analyse masses of born digital scientific data ndameheritage will deliver a generalisable approach a replicable methodology and an open and reusable digital ecosystem to build cathedrals of knowledge by the collaborative research on material objects by introducing and experimenting next generation methods and tools for the semanticdriven data production and analysis this project shifts the cursor of digitisation from the physical object to the knowledge for understanding it in order to analyse the interdependence between its complex facets and the related knowledge objects built by scholars through their research practices
guarddriven immunity against pathogens

successful pathogens use virulence factors to inhibit immune defenses to counteract this host guard proteins monitor the integrity of pathways guardees that are attacked by virulence factors such that inhibition of the guardee activates guarddriven immunity instead of directly detecting microbial components like canonical innate immune pattern recognition receptors guards are activated by sensing the activity of virulent microbes while guardimmunity is common in plants only a few mammalian guardpathways are known and mammals are thought to heavily rely on pattern recognition to detect pathogens we have recently described the morc3mre pathway the first mammalian guardsensing pathway that recognizes the virulence associated activity of viruses to induce a protective interferon ifn response i hypothesize that mammalian guardsensors are highly relevant for both immune homeostasis and immunity and propose to test this hypothesis by focusing on the morc3mre pathway utilizing genetic approaches in human monocytes and mice we will reveal novel components and molecular mechanisms of the morc3mre pathway and investigate its role in homeostasis and immunity in vivo the main hypothesis of this proposal is that guard sensing allows mammalian immune cells to broadly recognize the activities of virulence factors we aim to conduct forward genetic screens in human monocytes to identify virulenceassociated activities of pathogens that are sensed by the immune system functional genomics and biochemical approaches will identify the attacked guardee the guardsensor and molecular mechanism of guardsensing in summary we will experimentally test the novel concept of guardimmunity in mammalian immune defenses these experiments will generate fundamentally new insights into molecular mechanisms of pathogen recognition and will significantly broaden our understanding of innate immunity and hostpathogen interactions
exploring sustainable strategies to counteract territorial inequalities from an intersectional approach

the redrawing of social inequalities across europe during the last few years includes both a retrenchment of longstanding inequalities among countries and the emergence of new disadvantages together with an erosion of the status and protections previously enjoyed by most citizens within them this is particularly prominent from a geographical perspective as spatial inequality grows within regions despite overall country level economic growth certain regions are experiencing longterm socioeconomic stagnation or decline these areas have been often characterised as leftbehind yet little is known of what drives leftbehindness exit will provide an indepth analysis of leftbehind as a concept used for characterising territorial inequalities faced by certain areas and grounded on this identify strategies to address it this means not only building knowledge on the drivers of inequality in areas that are characterised as leftbehind but also on what drives political media and academic characterisations of these areas as leftbehind and experiences and perceptions of being leftbehind among inhabitants of areas experiencing socioeconomic stagnation or decline to answer these questions exit proposes a bottomup interdisciplinary and mixedmethods research with a communitybased and intersectional approach from the analysis to the transferability of practices addressing how different axes of inequality intersect in perceptions and experiences of leftbehindness is crucial to understand the gap between the development of policies to redress territorial inequalities and their impact on the ground in this regard exit proposes to take a placebased approach to delineate the role of different forces and how they interplay to produce uneven effects among communities
the function of b cells in myocardial infarctionaccelerated atherosclerosis

survivors of acute myocardial infarction mi are at a particularly high risk for accelerated atherosclerosis and recurrent atherothromobosis nevertheless mechanistic preclinical studies in atherosclerosis research worldwide are typically conducted in unchallenged without mi atherosclerosisprone mice and thus do not address the specific pathophysiology of postmi atherosclerotic cardiovascular disease we conducted a singlecell rna sequencing coupled to b cell receptor bcr sequencing analysis of sorted cd45 splenocytes from atherosclerosisprone mice that were fed an atherogenic diet for eight weeks in total and were subjected four weeks after the initiation of the atherogenic diet feeding either to sham microsurgery or to permanent ligation of the left anterior descending coronary artery to induce mi we found that splenic mature b lymphocytes from atherosclerotic mice that suffered an mi display altered glucocorticoidinduced responses and a more diversified bcr repertoire which contains twelve unique clonotypes named bmiracle clones that are not present in atherosclerotic mice without mi here i aim a to investigate the effect of glucocorticoidinduced signaling in b cells in postmi atherosclerosis in vivo by employing mouse models that allow the inducible genetic manipulation of different components of the glucocorticoidinduced signaling axis b by utilizing the full heavy and light chain nucleotide sequences from our single cell bcrseq data to clone and produce the respective antibodies of the bmiracle clones and examine their effect in accelerated atherosclerosis after mi in vivo and c to address the relevance of these findings in atherosclerosis progression in patients with a recent mi by analyzing sorted peripheral b cell subsets and serum samples these studies may lead to the identification of precise therapeutic targets for secondary prevention of cardiovascular disease
twinning laboratory for an innovative global hub to explore the deep

twilighted is a groundbreaking horizon europe twinning project that seeks to revolutionize deepsea research development and innovation rdi in portugal ultimately benefiting all of europe collaborating closely with the esteemed european institutions of geomar germany and ntnu norway twilighted aims to transform arditi madeira portugal into a global hub for deepsea rdi focusing on the challenging mesophotic zone 40200m and the enigmatic twilight zone 2001000m and capitalizing on madeiras unique proximity to deep waters twilighted will help accelerate our global understanding of the ocean and its essential role in sustaining life on earthtwilighteds key objectives are to 1 collaborate across research institutes in europe 2 elevate the research profile of portugal and especially the european outermost region of madeira 3 innovate lowcost alternatives to stateoftheart deepsea research technologies 4 democratize deepsea research 5 globalize deepsea rdi and 6 share ocean science across stakeholdersto achieve its objectives twilighted will adopt stateoftheart approaches to training and networking development activities include staff exchanges expert visits training schools joint research missions the international twilighted conference and novel crosssector workshops stimulating creativity in solving the oceans greatest challenges the impossible things workshops such capacitybuilding will not only catalyze deepsea rdi in madeira but ensure a lasting impact on the deepsea scientific landscape sustainable ocean policy and madeiras socioeconomic developmenttwilighted marks the start of a transformative journey for portugal redefining its role in understanding and protecting vital deepsea ecosystems twilighted will also facilitate greater diversity and collaboration in timecritical matters of ocean sustainability and leave a significant mark on the global pursuit for more democratic science
characterization of natural and modified plant nucleotidebased immunity signals as potential agents for crop protection

disease in crop plants is the major cause of lost productivity and economic hardship globally new environmentally sustainable approaches for enhancing plant resistance to newly emerging pathogen strains are much needed recent studies by the groups of jijie chai at uni kölntsinghua university with jane parker mpipz led to the discovery of four chemically related nucleotidebased compounds that are produced naturally by plants upon pathogen attack to promote immune responses against a broad range of diseases the biochemical modesofaction of these small molecules was determined and the chemical synthesis of several pure analogs successfully achieved these advances provide a basis to i explore further the immunepotentiating activities and dynamics of nucleotidebased signals in plant cells and tissues and ii develop and test modified forms of the signaling molecules for increased uptake bioactivity and stability in plants the aim of this proposal is to combine knowledge of nucleotide chemistry and modifications kathschorr with in vitro and in vivo functional assays parker with a view to designing a disease resistancepotentiating agent with broad efficacy on crops
cloudaerosol interactions their impacts in the earth system

cloud aerosols and their interactions are key regulators of climate however uncertainties in the magnitude of the net cooling impact of aerosols on climate and in the cloud response to evolving anthropogenic emissions and climate change induced feedbacks on natural emissions are major challenges that limit our understanding of how global and regional climate including extremes respond to changes in greenhouse gases it is of paramount importance to better understand aerosolcloud processes and their role in the earth system from regional to global scales and over different time scales from days to decades over the last decade extensive research networks infrastructures satellite instruments and atmospheric models have been developed making it possible to obtain a holistic view of the effects of clouds and aerosols on climate and weather certainty will capitalise on this available data together with advanced algorithms machine learning and data assimilation methods high resolution models and earth system models to bring the fundamental knowledge of interactions between clouds aerosols and radiation to a new level the consortium partners are in key roles as operators data originators developers providers and users of european aerosol and cloud data and esmshigh resolution models the consortium leads the activities of next generation satellite missions such as earthcare and the development of new satellite products to facilitate their scientific use in certainty by preparing tools for early adoption of data certainty will bring the observationbased knowledge to be used in modeling frameworks to improve predictive models and knowledge of processes controlling aerosols clouds and their interactions from hours to decades the ultimate outcome will be better understanding and predictions of extreme events that facilitates planning of climate mitigationadaptation strategies for the good of european citizens and global society
assistive medical robotics for very early mobilization of critical care patients

early mobilisation in the icu is a highly effective tool in patient rehabilitation clinically proven and acknowledged by major international medical bodies despite the clear financial advantages for healthcare systems and health benefits for patients it is currently performed with only 25 of icu patients due to lack of resources and hazardous nature of the manual procedure reactive robotics has developed vemotion the worlds first aidriven robotic assistance system for early mobilisation in icus vemotion enables the clinically proven benefits of early mobilisation to be delivered safely to all icu patients accelerating recovery by 20 reducing treatment costs increasing icu capacity by 27 and improving patient outcomes introduction creates a 5bn market for icu roboticsthe eic project 25m grant 15m equity delivers crucial product development and largescale clinical trials to validate the clinicalbusiness case and accelerate scaleup
processing complex matrices description reactionseparation modelling

the dream project focuses on the transformation of complex matrices for the chemical industry of the future it will focus on kraft black liquor as a case study it proposes to design new intensified processes coupling reaction and separation in continuous mode to fractionate a complex matrix deepeutectic solvent desassisted extraction of lignin coupled with depolymerisation co2assisted lignin segregation coupled with pyrolysis and membrane filtration coupled with oxidative depolymerisation each fraction will then be valorised into products of interest through reactive distillation or catalytic upgrading these processes will be monitored by original descriptors designed using data from online analysis the modelling of each reaction and separation step will be carried out based on these descriptors to give modules that will be assembled in a global simulation of the process the interdisciplinary approach combining biomass chemistry catalysis and chemical engineering will be enhanced through educational methods to overcome epistemological cognitive and communication barriers between disciplinesthe dream project represents a radically new approach for studying complex matrices combining cuttingedge technical expertise with social and philosophical expertise to address challenges of the interdisciplinary research process by developing new descriptors models and integration strategies it aims to establish a feedstockproduct relationship and design new more efficient and greener processes as well as new interdisciplinary methodologies
chiralitysensitive nuclear magnetoelectric resonance

this project lifts the blindness of nuclear magnetic resonance nmr spectroscopy to molecular chirality first we will observe chiralitysensitive magnetoelectric effects based on these effects a new branch of molecular spectroscopy abbreviated as nmer is proposed which will enable us to identify enantiomers directly without requiring chemical shift reagents or chiral solvents direct chiral nmr effects are very small and have not been previously detected but this proposal will utilize several unique new strategies such as hyperpolarization techniques and novel instrumentation to dramatically enhance the chiralitysensitive nmr signals this new approach is necessary to observe chiralitysensitive effects in solution at frequencies lower than 10 ghz it permits 1 the direct discrimination of chiral molecules 2 selective magnetic resonance imaging mri of chiral molecules and 3 determination of the absolute configuration of the molecule in contrast to standard methods used in nmr it does not require chemical modification of the sample consequently it has many potential application fields ranging from analytical chemistry determination of enantiopurity resolution of complex mixtures of chiral substances biochemistry studies of interactions between chiral molecules pharmaceutical science diagnostic imaging studies of the pharmaceutical mechanism of action at the same time the new methodology will dramatically increase the detection sensitivity rendering it possible to 4 record nmr spectra from molecules in the gas phase under conditions of low partial pressure this unique form of spectroscopy will be used as an analytical tool and will permit studies of chiral molecules interactions in combination with state of the art quantum computations it will provide valuable data on nmr tensors and allow models of fundamental interactions involving chirality to be tested on the molecular scale
towards a sustainable eulac partnership in research infrastructures

h2020 eulac resinfra project served to boost the biregional collaboration on research infrastructures ris between european union eu and latin america and caribbean lac countries to this aim a variety of different activities were developed that have proven the importance of ris as a key pillar in boosting the rd activities between regions and the need to maintain a sustainable collaboration at governmental level despite the success of the results of eulac resinfra project there is still work to do in order to have a solid and sustainable framework of cooperation to enhance the biregional collaboration on research infrastructureslatin america and the caribbean has a unique landscape of natural laboratories that can provide comparative advantages to host the development of ris as well as high impact science on specific thematic areas that are a priority in both regions it has been deemed necessary to increase the visibility of both eu and lac ri models and characteristics to advance in a greater collaboration for a common roadmapping exercise agreements in long term funding transnational access capacity building and mutual openness for the development of a ris common area eulac resinfra plus has brought together a wide and comprehensive consortium of 20 crucial partners from the eu and lac countries the project includes a balanced mix of governmental representatives responsible of the development of ris policies at national level rtd funding agencies from eu countries finland germany italy portugal romania and spain and lac countries argentina brazil colombia costa rica cuba chile peru and uruguay as well as a consolidated group of european ris instructeric lifewatcheric ricap and mirrieric this broad spectrum of partners gathers to all the ris stakeholders to ensure that the project activities and outputs serve to strengthening the biregional collaboration