Dragon09/odtu_chatbot huggingface dataset:
accessible innovative methods for the safety sustainability assessment of chemicals materials

the chiasmas central objective is to develop a new and improved safety and sustainable by design assessment framework based on innovative inproject validated in vitro and in silico methods new approach methodologies nams and data for the next generation of hazard risk assessment of chemicals and materials the developed nams cover main human target organs and exposure routes the chiasma assessment framework will be based on an iterative multistep approach based on next genaration safety assessment ngsa that combines chemocentric and biocentric approaches and nams and it will be able to predict regulatory relevant endpoints and longterm safety together with absolute life cycle impact analysis lcia developed methods will be demonstrated for scienfic soundness and performances and for transferability including to industrial environment prior to submission to regulatory bodiesdemonstration of the ssbd framework in at least three chemicalsmaterials groups pfas 2d materials for energy applications and nanopesticides supported by the assessment of socioeconomic aspects and gap analyses in the context of existing methodsintegration of the new improved methods for expressing safety and health parameter into existing lifecycle and sustainability assessments methodologies and tools as well as into the relevant applicable regulatory frameworks incl the ssbd frameworkprovision of accessible data for industry and public authorities in order to ultimately support the wider implementation of the ssbd framework and its criteriathe chiasma project will run for 48 months it is organised interdependent workflows which will be broken down into 9 workpackages aligned with the scientific plan in order provide an optimum projectconduct and achievement of project objectives
data is the new oil a political history of the european computing industry

the data is the new oil a political history of the european computing industry project investigates the history of the european computing industry from the aftermath of the second world war until the present the research will be based primarily on companies archives state archives and the historical archives of the eu and will place the evolution of the european computing industry in relation with the development of a european oil industry the most successful example of developing a strong and globally competitive europemade industry against americas firstcomer advantage by analysing the reasons of the failure to also establish strong european actors in the it industry the project will allow to better understand the reasons for the decline in european productivity as well as what the role of the european union eu can be in promoting the development of national or infranational strong it companies able to compete with the current dominance of us companies alone furthermore the project will consider the problem of the data economy in a historical perspective analysing access to data as a commodity in parallel to the problem of access to oil which dominated the geopolitical economy of the 20th century testing the literature on the history of commodities on access to data this will allow to cover a gap in the current literature on the history of the european computing industry which focussed almost exclusively on hardware and software it will also update the literature from international and media history with a reflection rooted in history on the role of data for current economic development
role of the kinase taok2 in the innate immune response to viral infection

viral infections are a major threat to public health worldwide the innate immune response acts as the first line of defense during viral infections by recognizing pathogenassociated molecular patterns such as doublestranded rna dsrna impaired innate immune signaling sensitizes patients to viral infections while aberrant innate immune activation is associated with autoimmune diseases recently the host laboratory identified the protein kinase taok2 as a novel cofactor for viral dsrna sensing taok2 binds and is activated by dsrna and its depletion leads to an impaired immune response to viral infection notably a mutation in taok2 causes immunodeficiency in human patients these findings suggest a previously unappreciated role for taok2 in innate immunity but the molecular details remain uncleari will use synergistic biochemical systems biology and in vivo approaches to comprehensively define the role of taok2 in innate immunity first i will use stateoftheart biochemical and structural approaches to define the mechanism of dsrna recognition by taok2 and discern the molecular basis for the diseasecausing point mutation second i will perform a multilevel systems biology analysis to integrate taok2 into a dynamic signaling network in response to viral infection third i will assess the consequences of complete loss of taok2 and the clinically relevant taok2 point mutation in vivo using mouse models this highly interdisciplinary and collaborative project will combine my existing expertise in biochemistry and in vivo approaches with the systems biology competencies of the host laboratory thereby i will gain novel insight into the signaling network that governs the innate immune responses to viral dsrna the training during this project will increase my scientific and transferable skills reintegrate me into the european research community and thereby help me achieve professional maturity and academic independence
the canopy of heaven under a microscope cataloguing medieval roofs cameroofs italy the roofs of churches in the veneto hinterland between the 5th and 15th centuries

one of the most fascinating aspects of medieval churches are the complex wooden frames of the roofs and the ceilings or vaults that dominate the interior cataloguing medieval roofs cameroofs provides a multidisciplinary research on the roofing systems external roof internal wooden supporting structure ceilings and vaults of churches built between the 5th and 15th centuries with the goal of creating a digital geodatabase for the architecturalhistorical study the history of restorations the typologicalstructural classification the cultural contextualization and the state of conservation of the roofs this preliminary stage of the project will focus on a specific territory that has preserved several cases of original or at least largely intact medieval roofing systems despite restorations or modifications the hinterland of the veneto region north italy this area is unique in italy for its peculiar position because it has received diversified cultural influences through the centuries from east to west up to northern europe which favoured the creation of different types of structures 12 major monuments will be analysed in this way it will be possible to have an exhaustive sampling of all types of roofing systems built between the early middle ages and the gothic era cameroofs has the ambition to be a pilot project in italy based on solid european research experiences in this field the project aims at creating an advanced and generalized system for the study and cataloguing of medieval roofs that can be continuously implemented and which will benefit the documentation conservation and management of medieval architectural heritage in the long term thanks to the collaboration of other researchers it will be possible to use this geodatabase on a much larger scale to highlight diversity and aspects that unite across space and time geographically distant churches with the goal of creating a european corpus of medieval roofs
invigorating enlargement and neighbourhood policy for a resilient europe

how can the eu invigorate its enlargement and neighbourhood policy to enhance europes resilience invigorateu aims at finding answers to this question by pursuing three overarching goalsour first goal is 1 to investigate how to reform the eus enlargement strategy in a new geopolitical phase how to respond to other actors geopolitical ambitions in the eastern neighbourhood and western balkans and how to rebuild the eus foreign policy arsenal in view of a new era of military threats triple r approach combining the modernisation and geopolitical logics of eu enlargement leading to new data eg a public opinion survey in ukraine a set of scenarios an external influence index russia china turkey and a social policy compliance and cohesion scoreboardour second goal is 2 to elaborate an evidencebased forwardlooking vision for the eus political agenda and institutional frameworks for codesigning a multidimensional toolbox ie two tailormade toolkits together with invigorateus expert hub civil society cs network youth labs workshops for young professionals and policy debates in a gaming set up which will result in contextsensitive and actionable policy recommendations for european and national political stakeholders and young european citizens in particularour third goal is 3 to deploy a cde communication dissemination and exploitation strategy aiming at recommendations from day 1 to maximize our scientific policy and societal impact in invigorating the eus enlargement and neighbourhood policies to enhance europes resilience ultimately invigorateu is a deliberately large consortium respecting the diversity of europe and political perspectives 7 out of 18 are from georgia moldova ukraine and the western balkans north macedonia montenegro serbia complemented by our cs network of 9 representatives from all western balkan countries georgia moldova and ukraine
informationbased strategies for land remediation

the informationbased strategies for land remediation islandr project is crossdisciplinary and multiactor and aims to promote the delivery of green deal objectives in particular achieving zero pollution by reducing soil pollution and enhancing restoration islandr will provide a series of tools and methods to support 1 the delineation of soil pollution sources 2 the assessment of risks 3 the implementation of sustainable and riskbased land management srblm 4 the inclusion of wider valuation approach in financial and investment cases 5 closer integration of land contamination and spatial planning decisionmaking and 6 key policy relevant findings related to the soil strategy proposed soil health law and other areas of policy where soil is a crucial consideration islandr takes a carefully targeted approach in view of the large existing knowledge base and has designed its outcomes be easily assimilated by multiple target groups incl policy interests planners and regulators site managers and their service providers care is taken to ensure support for capacity building and also to service the needs of long term repositories eg euso innovations include using cba to provide robust valuation for parallel benefits to improve business cases a technical basis for soil functionality as a soil health receptor and operating window analyses of nbs and other low input remediation islandr makes use of 7 test areas across europe to provide real world research context and roadtest findings including areas impacted by green transition consequences roundtables in these areas provide active local stakeholder dialogue and a basis for rapid implementation and new project rollout a key focus of islandr is to facilitate soil remediation in situations where the case is economically marginal or negative by providing a more thorough understanding of low input approaches and a wider value proposition for investment cases and financial planning
resilience estimation to set management goals in marine ecosystems

in the anthropocene global and local cumulative human pressures are heavily impacting ecosystems and threatening societies maintaining resilience ie avoiding irrevocable system changes is the only way to maintain the critical services that an ecosystem provides and should be an objective of management recently resilience has been deeply studied theoretically sparking interest in the whole scientific community however its integration into management practices is still rare due to methodological limitations standardised and applicable methods to estimate resilience empirically in natural systems are lacking reset will develop a framework to concretely estimate resilience in marine ecosystems and integrate it into management the framework will be built on highquality and innovative statistical methods and on the local ecological knowledge lek of fishers the work will be carried out in chioggia a city hosting a major mediterranean fishery and a perfect location where universities research institutes fishers and management bodies have a long story of collaborations using longterm time series of the northern adriatic sea an ecosystem hotspot of global changes and human pressures in the mediterranean sea reset will apply a threestep modelling approach to estimate resilience the knowledge deriving from the modelling approach will be complemented with the lek of fishers synthesised through structured interviews and participatory meetings the inclusion of fishers in the process will favour a more proactive management approach finally reset will readily transfer the new methodologies and knowledge into management by cooperating with ispra the italian public body responsible for the application of the marine strategy framework directive the ecosystembased management approach of the eu the realisation of these three objectives will favor the integration of different approaches which is fundamental in order to sustainably exploit our resources
spin curves enumeration

enumerative geometry aims at counting geometric objects that satisfy specific algebraic conditions the modern treatment of enumerative problems of curves has revealed deep connections between geometry representation theory and theoretical physics these connections are established through the cohomology of moduli spaces of curves the description of the structure of these cohomology groups is crucial in this modern perspective and i will use spin curves to address this issue spin curves are refinements of curves carrying an extra sign or that enables the construction of new cohomology classes called spin classes spin classes carry rich algebraic structures that can be used to investigate enumerative problems in the spice project i will study 2 open problems with this approachproblem 1 dubrovin defined frobenius manifolds to study deformations of enumerative problems at a cohomological level how can we describe singular frobenius manifoldsproblem 2 how to enumerate curves in surfaces of general typespin curves have been extensively studied through techniques from several branches of mathematics yet a general framework is missing in spice i will combine my expertise in these fields to consider spin classes from a unified perspective this novel approach will provide the means to prove structural results and enable significant progress on problems 12 problems 12 revolve around 3 fundamental families of spin classes and their interplay which frame the 3 work packages wp of spice and their respective goalswp a wittens class prove a spin reconstruction theoremwp b gromovwitten theory establish virasoro constraints for spin curveswp c strata of differentials express spin wittens class via moduli spaces of differentialsthe outcome is a framework that provides new methods to compute spin classes these effective techniques pave the way for longterm research on the deep algebraic structures associated with problems 12
promoting investments in nbs and accelerating market uptake by gaining a better understanding of the economic performance of nbs considering climate mitigation and risk reduction

currently there is a range of naturebased solutions nbs emerging mostly with strong public funding elements but a market for nbs has not yet emerged while mostly small scale nbs are implemented as pilots for urban resilience to climate change the full range of economic and societal benefits for nbs are not systematically understood and mapped and are not sufficiently used to back the business and investment case for nbs the numerous benefits may include mitigation and adaptation to climate change including the reduction of urban heat island effect and flood mitigation reduction of pollution improved biodiversity and ecosystem services increased wellbeing for citizens including physical and mental health or recreation social cohesion and community building while effort for climate change mitigation and adaptation are increasing the role of nbs in this context is not well understood in particular risk reduction of nbs for the private and public insurance sector has not yet been systematically included in economic valuation of nbs holistic understanding of benefits and benefit flows however are important for the society including upscaling and maximising the benefits achievable with nbs and activation financing for nbs the overall project aim of invest4nature is to gain a better understanding of the economic and financial performance of nbs considering their role for mitigation as well as climate risk reduction to promote upscaling and investments in nbs and to accelerate market uptake the project has a strong involvement of stakeholders to coproduce solutions having several nbs living labs and a wide nbs community including project developers decision makers and funding and financing institutions at hand coproducing new evaluation and financing approaches as well as tools covering nbs in different contexts eg urban rural coastal this is the basis for empowering stakeholders and create and structure a future nbs market
modulating the physicochemical properties of polymerbased nanovaccines to communicate with immune cells

understanding the relationship between the structure of drug formulations and their function is of utmost importance for the prediction of treatment outcome this has become highly apparent from the recent development of lipid nanoparticlebased vaccines to prevent covid infections it has also become clear that many questions remain which require a robust approach to this exciting field of nanomedicine this project aims at precisely modulating supramolecular nanovaccines systematically investigating their interaction with immune cells and finally establishing the relationship between the physicochemical properties and the immune response pathways the supramolecular nanovaccines will exploit block copolymer vesicles polymersomes as scaffolds which will be decorated with immune active antigenic and adjuvant oligopeptides on their surface such minimized supramolecular vaccine design enables flexibility with regard to physicochemical properties in terms of size shape and surface character the interaction of this library of nanovaccines with immune cells will provide a deeper insight in how different immune responses can be provoked by precisely controlling the physicochemical properties of the nanovaccines the project will explain cascade signalling pathways on both the cellular and molecular level with as final target to aid in vaccine design for especially tumor immunotherapy
systems of transmitting early modern manuscript verse 14751700

stemma offers the first largescale quantitative analysis of the circulation of early modern english poetry in manuscript between 1475 and 1700 it addresses a significant gap by developing innovative computational methods for studying the social and material forces that informed literary culture scholars have tended to address individual manuscripts as case studies in contrast stemma revolutionizes the study of manuscript poetry by taking a datadriven approach to identify patterns and trends at scale at its centre is the poet john donne whose reluctance to circulate his verse makes the survival of at least 4249 manuscripts of his work all the more puzzling the poems of his next mostcirculated contemporary survive in fewer than 1000 witnesses to understand how donnes poems and early modern poetry more generally circulated throughout the englishspeaking world the project synthesizes six of the most comprehensive datasets about early modern manuscripts and applies insights from social network analysis and graph theory to model the larger transcontinental communications system the projects objectives are to provide the first comprehensive study of early modern english manuscript verse circulation to combine augment and enrich the most important bibliographical datasets and return them as linked open data to develop transferable and extensible methods for analysing the circulation of manuscript poetry to offer a thoroughly revised account of the production and circulation of literary manuscripts after the introduction of print to provoke a reassessment of historical metanarratives that privilege print and obscure the diverse agents who participated in early modern literary culture and to facilitate new modes of research and discovery the project offers benefits for scholars of early modern europe as well as those working on computational and digital projects addressing a range of time periods national traditions and disciplinary orientations
concerted european action on sustainable applications of refractories

refractory materials are key enablers for high temperature industries such as iron steelmaking is refractories are sophisticated materials designed and optimized to sustain severe operation conditions inducing complex combinations of thermomechanochemical damage mechanisms nevertheless refractory material consumption has been reduced over the last 50 years from more than 35 kg of refractories per ton of steel to about 10 kgt in the european steel industry while keeping safety of the utmost importancethe movement of the is industry towards netzero emissions and digitalized processes through disruptive breakthrough technologies will be achieved through the use of hydrogen the biggest challenge for the refractory industry is to continue to meet the performance expectations while at the same time moving to a more sustainable production directionthe complexity and urgency of these technology changes highlighted by the european green deal requires a concerted european action on sustainable applications of refractories cesaref a consorted and coordinated european network with steel refractory raw material producers and key academic poles will tackle the following key topics efficient use of raw materials and recycling microstructure design for increased sustainabilityanticipation of hydrogen steelmakingenergy efficiency and durabilitywhile creating new developments in the is and refractory industries the network will train highly skilled doctoral candidates capable of communicating and disseminating their acquired knowledge cesaref will create a core team across the european refractory value chain accelerating the drive towards the european refractory industries push towards sustainable materials and processes as well as netzero emission steel production this will help to create and secure sustainable employment in the european refractory and is industries