Dragon09/odtu_chatbot huggingface dataset:
efficient and functional optical frequency conversion in 3d nonlinear optical artificial materials

optical frequency conversion in bulk nonlinear crystals is used for generation of coherent light over the entire optical regime from extreme ultraviolet up to thz waves this remarkable ability is at the core of a plethora of important technological and scientific applications however bulk nonlinear crystals pose strong limitations on integration miniaturization and control over the nonlinear interactions holding back the further progress of optical frequency conversion technologies i propose to lead a great breakthrough in the field by developing a new kind of 3d nanoengineered nonlinear optical artificial materials with superior nonlinear optical properties and free of the limitations of bulk nonlinear crystals these materials will be inspired by recently developed nonlinear metasurfaces it was demonstrated that nonlinear metasurfaces exhibit unprecedented nonlinear functionalities and effective nonlinearities exceeding by far those of bulk nonlinear crystals promising to replace bulk crystals in future nonlinear optical technologies however their twodimensional designs and nanoscale thickness strongly limit their frequency conversion efficiency with no existing practical nanofabrication approach nor theoretical proposition to overcome this limitation our research aims to close this gap we will develop a new nanofabrication methodology that will allow to stack hundreds of nonlinear metasurfaces into a 3d nonlinear material in a technologically viable way we will study new fundamental nonlinear interactions in these novel nonlinear materials and demonstrate experimentally their superiority over bulk nonlinear crystals in conversion efficiency and functionalities these achievements will potentially pave the way to the next era of nonlinear optical frequency conversion technologies they will also immediately impact applications of 3d nanostructured optical materials in general as well as may change the way we think about 3d nanofabrication
evolutionary dynamics of genomic erosion and its application in biodiversity conservation

reducing biodiversity loss is one of the most pressing societal challenges of our time population decline has put many species on the path of collapse and extinction reducing or reversing this decline is not enough to tackle the associated hidden evolutionary costs most notably genomic erosion which compromises the longterm viability and resilience of species erode will employ stateoftheart approaches paleogenomics quantitative genomics and evolutionary modelling to assess the dynamics of genomic erosion on neutral beneficial and deleterious variation and understand its effects on organismal fitness population viability and extinction risk i will perform one of the most comprehensive genomefitness studies to date by examining the fitness effects of genomic erosion over time in 6530 individuals of three iconic endangered bird species for which i have access to over 30 years of genetic samples and fitness data together with zooarchaeological and museumpreserved samples i will draw a dynamic timeline of genomic erosion in response to population decline next i will develop a modelling framework parametrized and validated with empirical data to predict the consequences of genomic erosion i will use this framework to understand the efficacy of insitu and exsitu conservation strategies in collaboration with the european association of zoos and aquaria eaza the computer model will incorporate genomics into the green status of species to evaluate species recovery and conservation impact in collaboration with members of the international union for conservation of nature iucn erode will produce one of the largest genomic datasets for endangered species in the world and a robust modelling framework for conservation scientists and practitioners the outputs will be disseminated in academic journals but also over a series of workshops instruction videos and other outreach activities which will support their practical application
towards the clinical implementation of trem2 microglia engineering for treating dementias

trem2meds emerges from the erc poc 2022 project trem2engines grant agreement id 101069395 which validated the efficacy of a novel treatment for alzheimers disease ad and nasuhakola disease nhd in murine models a relevant proportion of ad cases and all forms of nhd are caused by pathogenic mutations in the trem2 gene which lead to microglia dysfunction contributing to andor causing the onset and manifestations of ad and nhd trem2meds approach involves the transplantation of hematopoietic stemprogenitor cells hspcs engineered by lentiviral vectors lvs to express robust levels of the triggering receptor expressed on myeloid cells 2 trem2 in their central nervous system cns myeloidmicroglial progeny the engineered cells have shown the ability to reduce and prevent a accumulation mitigate neuroinflammation and restore physiological scavenging functions in the diseased cns benefiting ad and nhd in robust animal models in trem2meds we will exploit these findings for transition of the approach from trl 4 to trl 56 by generating impdenabling data and packages that will allow launching at project completion a firstinhuman phase i clinical trial of trem2hspc gene therapy in ad nhd patients carrying trem2 hypofunctional variants the restoration of trem2 function in microglia by intervening on key mechanisms contributing to neurodegeneration has the potential to overcome the limited efficacy of current treatments for ad which only exert symptomatic but not curative effects through this work we will thus bring to clinical testing an approach intended to become the benchmark in the treatment of ad and nhd and possibly other dementias
molecular receptors enrich methylated and acetylated peptides for ultrasensitive proteomics to explore the hidden modified proteome in disease

scientific studies indicate that inefficient epigenetic control is associated with a wide variety of noncommunicable diseases ncds like cancer schizophrenia and diabetes indeed histone post translational modifications ptms are crucial for many cellular processes including transcription and dna repair thus the ability to readily and reliably detect ptms is crucial to better understand epigenetic processes and the complex functions of histone ptms in human diseases mass spectrometry ms is the technique of choice to identify such modifications across the proteome ms requires an enrichment step generally performed using antibodies but these have several limitations such as high costs batchtobatch variability and data reproducibility in a multidisciplinary effort enrich aims at developing new costeffective fast and efficient tools for the enrichment of post translationally modified proteins overcoming the current limitation enrich will functionalize nanoparticles nps with molecular receptors able to enrich ptmcontaining peptides derived from proteolytic digestion for subsequent ms analysis concurrently the ability and selectivity of the synthesized receptors and functionalized nps will be evaluated via spectroscopic analyses the enrich network gathers the expertise required to tackle this challenge the consortium is composed of 9 highlevel academic research groups from 2 different continents europe and america and 2 highly innovative companies by the seconding of 87 erserss across europe and worldwide the aim is to capitalize on the consortium expertise in complementary fields such as chemical synthesis spectroscopy and proteomics the network promotes an effective integrate training of researchers boosting their career development and promotes collaborations between the partners the direct involvement of industries guarantees the timely exploitation of the results from research laboratories to innovative products
innovative energy storage technologies for the internet of things

at the core of the ongoing transformation of technology and energy systems lies the internet of things iot a network of interconnected devices capable of collecting and exchanging data with unprecedented efficiency and precision in this project we aim to develop two different experimental approaches to expand the knowledge gained from the pcap project to develop prismatic supercapacitor cells using our knowhow on coating carbon electrodes for supercapacitors and to develop planar capacitor cells with relaxor ferroelectric rfe materials making use of the techniques develop during pcap for the manufacturing of planar electrochemical cells the project will have a strong focus on benchmarking technologies with commercial cells market competitiveness analysis preliminary ip landscape unique value proposition preliminary budget estimation for scaleup all of which will be compiled in a business case
uncovering turgor sensing in the arabidopsis cambium

plant meristems integrate signals from water conditions to tune their proliferative activity and control growth while extensive progress has been made elucidating water stress responses in plants how cells in aerial meristems sense hydraulic fluctuations remains largely unknown the vascular cambium vc the largest plant meristem contributes to the radial growth of shoots and roots by producing xylem and phloem tissue theoretical models for cambial growth predict that waterdependent turgor pressure stimulates locally the proliferative activity in this meristem these models are extensively supported by correlative studies in greenhouse and field conditions yet how turgor pressure is sensed and transduced into a cell proliferation response is still unknown this is what i would like to investigate during my postdoc at the mhönen group to do so i will be trained in the design and implementation of the latest lineage tracing and genome editing tools from the hosting lab i will contribute with my background in meristem hydraulics to reveal the dynamics of cambial cells under water deficit since the vc is directly connected with watertransporting cells hydraulic fluctuations can have a direct physical effect in cambial cells more specifically at the plasma membrane where key osmosensors are localized therefore i will study the function of osmosensing channels in the context of cambial developmental plasticity finally i will identify regulators of cambial activity dependent on water status this project aims at 1 generating a growth rate and cell fate map for the cambium under variations of water status 2 identifying osmosensing channels involved in the control of cambial activity and 3 uncovering cambial molecular factors transcriptionally sensitive to water status taken together this project will provide me with a material and conceptual platform for developing a career studying the hydraulic control of plant growth
harnessing robotics xrar and 5g for a new era of safe sustainable and smart agriculture

agribot is a groundbreaking project aimed at advancing robotics as well as augmented and extended reality arxr technologies within the agricultural sector the projects overarching goal is to achieve a range of critical impacts including improving working conditions reducing environmental footprint addressing workforce shortages and enhancing overall sustainability and competitiveness in alignment with strategic initiatives such as the farmtofork strategy the common agricultural policy post2022 and the broader ambition of embracing the digital age agribot is poised to drive a transformative shift toward a fair safer and resilient agriculture sector
decorated paper in the earlymodern islamicate world aesthetics techniques and meaning in global contexts

moving away from eurocentric art historical to truly global and interdisciplinary approaches this project aims at reevaluating the earlymodern history of the islamicate arts of the book from a sofar not considered perspective the border and background decoration of manuscripts the manifold forms of paper decoration and their techniques have hitherto not been systematically analysed by historians of islamic art who instead have focussed on manuscripts figurative illustrations labelling decorative devices as subordinate to text and images has proven limiting to a full comprehension of art and to the exploration of global artistic contacts between different cultures within the islamicate world and between east asia and the middle east drawing upon previous research initiatives by the pi this project will bring together scholars from humanities and natural sciences in an interdisciplinary approach to aesthetics materials techniques and meaning of decorated paper produced and used in earlymodern china central asia iran india and the ottoman empire favouring objects in the historical centres over wellknown materials from collections in the west this research is designed to further collections in the middle east and asia and to bring their understudied artworks under broader scholarly attention through publications and an interactive database the project has the potential to significantly reshape the existing construct of art history by shifting the attention to highstandard yet systematically ignored artistic production of decorated papers meticulously investigating local traditions through innovative combinations of material analyses the study of written sources and hardly applied comparisons with contemporary paperdecoration practices and focussing on networks of trade diplomacy and artistic exchange in asia and the middle east that paved the way for greatly varied and technically advanced forms of augmented paper decoration
a novel and accurate emotion recognition system for realtime and continuous patient monitoring in psychiatry

150m people suffer from mental disorders in europe this number is sharply increasing there are not enough psychiatrists to cope with the situation a psychiatrist sees 1000 patients in sessions separated every 34 months psychiatrists have no way to know if a patients treatment is working and if there is any risk of relapsesuicide between sessions a patients emotional status gives insights into treatment effectiveness and diagnosis of major depressive disorder but there are no accurate tools to monitor emotions remotely and continuouslycephalgo has solved this challenge developed the first accurate remote continuous emotion tracker to monitor treatment effectiveness and predict the best course of treatment for a given patient profile combining speech analysis an aidriven emotion recognition algorithm our ai detects emotions with high accuracy predicts the best treatment to reduce the trial error approach currently employed in psychiatry
reduced or single pilot operation incapacitation safety enhancement

the resilient growth of global air travel continues to lead to ever busier skies and airports placing growing workloads on pilots and operators both in the air and on the ground as well as increasing the demand for pilots globally addressing these concerns will require technological solutions in the form of increasingly automated assistance systems to help alleviate pilot workload reduced crew operation extended minimum crew operations as well as fully autonomous solutions which can support single pilot operations spo in the event of pilot incapacitation on the other side the adoption of new operational procedures such as spo will have an impact on the ground operations and the atc operators responsibilitiesthe response consortium led by collins aerospace aims to deliver one trl2 solution safe return to land including pilot incapacitation the proposed solution directly support pilots incapacitation transition monitoring and deliver an integrated airtoground spo conops to enhance safe return to land operations in the project the consortium delivers a technology enabler as pilot incapacitation transition monitoring to detect pilot incapacitation and map cognitive states and degradation of human performance the solution delivered is a safe return to land conops introducing the role of airtoground digital assistants minimizing the required changes from dual pilot operations to spo including dealing with pilot incapacitation in the flight deck with the impact on atc operators tasks and with the role of human autonomyai teaming to support workload reductionresponse project builds on top of the outcomes and recommendations of safeland project and will enhance the execution of current projects in sesar3 industrial research actively contributing to the future preparation and delivery of a full demonstrator for safe return to land in the case of spo
shaping the bacterial envelope interplay between the components and impact on antibiotic resistance

gramnegative bacteria are notoriously resilient dominating the list of pathogens requiring urgent medical attention fundamental to their remarkable antibiotic resistance is a tripartite envelope comprised of an innermembrane im peptidoglycan cell wall pg and an outer membrane om while these layers were previously viewed as separate compartments it is becoming apparent that they work together in order to maintain envelope integrity however little is known about the crosstalk between components and molecular mechanisms orchestrating envelope assembly and functionality our latest work has identified a key interaction between the pg and the bam complex which inserts new om proteins omps revealing a mechanism coordinating pg and omp biogenesis and directing them both to the cell center we posit that coordination is a key principle of envelope assembly and multiple interactions among envelope constituents are waiting to be discovered in shapeenresist we will uncover novel physical and genetic interactions identify coordination mechanisms and elucidate their impact on bacterial physiology and antibiotic resistance to this end we will focus on three aims i explore the assembly of lipopolysaccharide lps an endotoxin covering the bacterial surface and characterize its interplay with envelope biogenesis ii comprehensively map pgomps interactions and study how they affect bacterial response to antibiotics iii uncover the outcomes of spatially heterogenous envelope biogenesis and whether this process is a source of phenotypic diversity to address these questions a multidisciplinary approach will be taken combining cuttingedge microscopy advanced genetic screens proteomics and novel functionality assays we expect this project to uncover the interaction network amongst envelope components reveal how it impacts the physiology of both single cells and bacterial populations and ultimately expose the secrets of bacterial resilience
lctb21 a dyrk1a protein kinase inhibitor for treatment of cognitive decline in down syndrome

all people with down syndrome ds suffer from a certain level of impaired learning and memory cognitive disorders from childhood onwards greatly impacting their autonomy and societal integration this is becoming an increasingly urgent issue as people with ds are more often outliving their care takers yet an adequate treatment has not yet been developedstudies have revealed that the cognitive decline in people with ds is associated with overexpression of the dyrk1a protein kinase in the brain perha pharmaceuticals has developed a novel therapeutic compound leucettinib21 lctb21 which acts as a dyrk1a inhibitor that can reduce cognitive decline in children with ds ultimately this will increase the autonomy of people with ds resulting in better societal integration perha pharmaceuticals aims to outlicense lctb21 to a large pharmaceutical partner eg otsuka pharmaceuticals intracellular therapies following a successful phase 2a clinical trial
innovative liquid biopsy method using labonachip technology for cancer diagnosis and management

jaxbio is a pioneering biotech startup company dedicated to transforming lung cancer diagnostics and treatment through innovative liquid biopsy and dnachip technology our team comprised mainly of phd experts in cancer biology data science and technology development is committed to addressing the critical challenge of early lung cancer detection and management the global impact of lung cancer claiming nearly 18 million lives annually highlights the urgent need for advanced diagnostic solutions over 70 of lung cancer patients are diagnosed at advanced stages resulting in poor prognosis and high mortality rates furthermore approximately 50 of patients receive suboptimal treatment due to a lack of methods to predict treatment response rapidly jaxbio addresses these challenges with lumen an innovative noninvasive liquid biopsy assay this method employs a custom chip designed for ultrasensitive detection of epigenetic signatures in cellfree dna complemented by an ai algorithm for identifying diseasespecific biomarkers our findings demonstrate lumens ability to detect cancer early even with extremely low tumorderived dna concentrations in the blood eliminating the need for dna sequencing lumen offers unparalleled accuracy in cancer detection as well as affordability it also provides valuable insights for personalized treatment approaches and early tumor recurrence detection with eic support our objective is to conduct clinical trials and complete the development of the lung cancer chip this chip will serve as a companion diagnostic tool predicting therapy response and assessing treatment effectiveness our goal is to bring a clinically validated product to market comprising reagents chips and analysis software ultimately enhancing cancer care and patient outcomes
enabling ewsgalileo market uptake in widespread pws solutions

in 2023 the european commission will launch the galileo emergency warning satellite service ewssewss is a worldwide service to broadcast emergency warnings linked to natural or manmade disasters with the major advantage to remain operational when all terrestrial communication networks are down and in places where they do not exist at allfinal recipients of ewss messages ewm are primarily citizens equipped with galileo enabled smartphones but another category of endusers exists public warning systems pws stakeholders for this latter a specific gnss equipment is needed to receive and process the ewm this equipment being integrated in fixed devices which alert citizens via audio video and text alert messages such as longrange acoustic devices or digital panels or adequate digital messages flows within it systemsthe purpose of the aware project is to develop this specific gnss equipment also secured by the osnma feature aware will also prepare the adoption of ewss by european civil protection authorities by performing activities in support to euspa and ec for the service deployment dissemination activities aiming at building the aware ecosystem within the pws b2b and b2g markets aware consortium gathers all the necessary competencies ensuring the success of the project with fdc as gnss receiver manufacturer telespazio and eena with experience on the design and deployment of public safety services gralle help112 cnes as operator of toulouse sargalileo service centre where the ewss service centre will be hosted end to end demonstrations will be performed with jcdecaux and genasys pws equipment providers and solution integrators and will involve customers such as the slovenian civil protection authority the bridge between galileo ewss and copernicus ems will also be showcased by unistrathe draft business plan demonstrates the consortium commitment to go to the market and the high probability of a quick roi