Dragon09/odtu_chatbot huggingface dataset:
transforming radiology with artificial intelligence to fight abdominal cancer

abdominal malignant tumours represent one of the groups of oncological pathologies with the highest prevalence and mortality annually new cancer cases related to organs in the abdomen pancreas liver kidney etc are diagnosed globally representing more than 14 million annual deaths worldwide particularly pancreatic cancer is the fourth cause of death by cancer in europe but it has the lowest 5year survival rate among the common cancerssycai technologies sl sycai is a deeptech company that has developed an artificial intelligence digital tool to assist radiologists to detect and classify abdominal lesions through imaging currently our tool prevents the abdominal lesions from progressing to pancreatic cancer with an accuracy superior to the standard identification proceduresby integrating this assistant in the workflow of radiologists with our 0clicks approach the information will be easily accessible by professionals to accelerate the identification of precursor lesions avoiding invasive tests surgeries and patient complications at sycai we have the vision to provide noninvasive tools to assist in the earlystage diagnosis of any type of abdominal cancer we aim to impact our society positively contributing to improving the quality of life of patients with abdominal lesions with a low probability of evolving towards malignant lesions additionally our solutions will improve the dedication of resources to patients needing prioritisation in cancer care according to the status of lesions therefore sycai contributes to public expenditure savings for a sustainable and resilient european healthcare system sara toledano ceo and julia rodrguez cso apply to the women techeu programme since they are eager to improve their leadership skills to face the challenge of market entrance in europe and to be prepared for sales operations and team growth
pushing from within control of cell shape integrity and motility by cytoskeletal pushing forces

the ability of cells to sense environmental cues and respond to them by adjusting their shape and motion is fundamental for biological processes ranging from animal development to disease much is known about how cells sense and respond to the geometry and mechanics of their environment by adhering to and pulling on the substrate however recent studies demonstrated that cells also strongly depend on nonadhesive interactions with the environment and that they probe sense and deform their surroundings by pushing into themthe goal of this project is to address the mechanisms controlling cell shape and cellsubstrate interactions via pushing forceswe will focus on three levels of cell organization1 nanoscale pushing we will investigate how cells locally sense and respond to obstacles without adhering to them and quantify the associated forces using microengineered substrates and tissue mimics we will molecularly and biophysically dissect biochemically reconstitute and theoretically model the interface between an obstacle the plasma membrane and the actin cortex2 mesoscale cell mechanics we will investigate how actin microtubules and intermediate filaments collaborate to generate and extend mesoscopic cell protrusions that push by adhesionindependent mechanisms we will combine cell biological experiments and optogenetics with modeling and bottomup reconstitutions3 global force balance we will examine adhesionindependent mechanisms that allow a cell to coordinate competing protrusions maintain its integrity and translocate in complex environments using biophysical measurements and local molecular perturbations we will test models of longrange communication within cellsour work will provide new fundamental insights into biological and physical principles underlying the control of cell shape integrity and motility which are key to most physiological processes from development and homeostasis to cancer immune responses and regeneration
selfassembled 2d chiral plasmene nanosheets for biomarker detection based on surfaceenhanced raman scattering

in this project i will develop chemical methods to synthesize colloidal chiral plasmonic nanoparticles and assemble them into 2d plasmene nanosheets chiral components on the surface of metal nanocrystals enantioselectively interact with chiral growthdirecting molecules such as amino acids and peptides leading to the asymmetric evolution of chiral plasmonic metal nanoparticles the chirality transfer from soft chiral molecules to inorganic metal surfaces derive from the highly twisted surface features on the nanoparticles induced by the chiral molecules during overgrowth i will synthesize chiral plasmonic nanoparticles with different morphologies finely tune the twisted surface elements adjust their interparticle spacings and orientation and optimize their chiroptical responses highly chiral 2d graphenelike plasmonic superlattices or plasmene nanosheets will then be fabricated on flexible substrates to serve as allhotspot practical chiral sensing platforms via control over interparticle spacing and orientation a novel functional chiral plasmonic biosensing platform will be constructed by the selfassembled 2d chiral plasmene nanosheets based on surfaceenhanced raman scattering for ultrasensitive biomarker detection and chirality discrimination
costeffective and replicable resintegrated electrified heating and cooling systems for improved energy efficiency and demand response

seeds unites a multidisciplinary and complementary team of smes les rtos and stakeholders that constitute the whole local value chain of energy efficiency in buildings and thermal demand electrification from planning design and construction to operation and commissioning seeds is built upon the consortiums vast experience in developing testing and valorizing decarbonization solutions supervising reallife demonstrations of building renovation and smartification and deploying energy flexibility seeds demonstrate replicable heat pump solutions integrated with renewable energy to decarbonize buildings thermal demand addressing that every building is unique and requires tailored solutions to be costefficient and energy efficient we develop scalable and generic design and operational optimization methodologies deploy multiple proven heat pump technologies at scale and optimally integrate them into the building and broader energy system seeds demonstrates these up to trl68 in 6 pilot sites incl 1 replication site providing realworld settings spread across the different climate zones and european construction markets seeds is centered around three key themes cost efficiency through optimization system integration through holistic design and control and replicability through configuration modularity and scalable building types these are addressed in 7 focus areas 1 iterative design of the component and integrated system 2 secure and interoperable data platforms and iot 3 integrated system optimization for energy efficiency and flexibility 4 deploying energy flexibility to enhance grid stability 5 replication strategies exploitation and business models 6 decision making support framework for replication and 7 dissemination communication and stakeholder outreach thanks to the 27 partners widereached field of impact and networks seeds is set out to boost the electrification of thermal demand in buildings
displacing universities refugee voices for higher education in europe

displacing universities refugee voices for higher education in europe displacingunis is a critical ethnographic study into university initiatives for displaced people the project interrogates differing approaches to refugee higher education he amongst students alumni teachers and admin staff across multiple scales in a historicallysensitive manner embedding the analysis relationally to changes in he civil societyactivist practices and european and local policies the research will be undertaken with the hope of improving the workings of refugee education initiatives eg in their focus scope aims pedagogies intersectional awareness university practices more broadly eg in recognition of prior learning for admissions trauma informed teaching and hes wider response to displacement and learning eg with education as a means of mobility and social justice for marginalised learners aside from scholarly and publicfacing outputs ie articles a book proposal audio documentaries podcasts the project will include specific recommendations for existing initiatives and produce an eulevel policy paper on the role of initiatives for displaced learners access and success in he this will be reworked into locally specific toolkits for he practitioners and policy makers data will be gathered on both a global level via a collaborative podcastingasresearch method and through three case studies in dublin budapest and barcelona including via participant observation interviews curriculum analysis and participatory audio documentary production i am an anthropologist and refugee education practitioner and will use the fellowship to build on my experience to develop expertise in both refugee and higher education studies as well as knowhow in cutting edge participatory methods and effective policy intervention
gaia cofund

gaia cofund will bring climate researchbased knowledge climate mitigation and adaption into help solving real world problems and challenges by connecting science with society in a practical manner targeting research through a transdisciplinary approach involving industrial partners we will pave the way for a climate academic career paths into industry an eligible applicant will carry out a research project that will enable them to become future leaders either in academia or in industry the main objective of gaia is to fund 15 twoyear postdoc fellowships to excellent and promising young scientists from all over the world with a strong emphasis on secondment in industry gaia will establish a postdoctoral training program that combine excellent and responsible research open science innovation and climate change challenges thus laying the foundation for the next generation of researchers rooted in climate science with a global outlook and an enduser perspective with 24 partners gaia will offer access to an extensive academic and nonacademic network europe wide the program will enable university of southern denmark sdu to elevate its strong position in climate research with world leading research groups broaden the scope and sustainability of emerging research areas and facilitate a vibrant and even more attractive research environment combined with an outreach to local and international industrial partners looking for sciencebased solutions sdu has 27000 students and 3800 employees with 24 departments within the faculties of the humanities social sciences natural sciences health sciences and engineering sdu is ranked among the top universities in denmark gaia will be part of the sdu climate cluster scc established in 2022 with a budget of 15 m to create a versatile platform for groundbreaking excellent and interdisciplinary research within climate mitigation and adaption
understanding and targeting cancer persister cells

despite tremendous progress in cancer therapy many patients still succumb to the disease following an initial successful response to treatment in addition to the longappreciated contribution of genetically mutated cells to disease recurrence persister cells a rare subpopulation of cells that evade therapy in the absence of any known resistancemediating mutation have recently emerged as orthogonal drivers of therapy failure while there has been much progress in targeting genetic resistance the paucity of molecular tools that can capture persister traits as well as the lack of a robust methodological framework for their study have significantly hampered our understanding and ability to target persister cells nevertheless recent breakthroughs in molecular profiling techniques as well as growing access to human residual disease clinical samples now provide the opportunity to uncover the molecular underpinnings of this crucial cellular state in this project i propose to combine stateoftheart singlecell lineage tracing techniques with functional approaches to 1 identify the determinants that control the ability of persister cells to escape therapyinduced senescence 2 elucidate the cellular processes that govern the duration of persister druginduced arrest 3 investigate how epigenetic memory shapes persisters response to subsequent cycles of therapy cancerpersisters will establish the tools that are needed in order to study key persister traits and further our understanding of this important cancer phenotype successful completion of this project may instruct the development of new classes of cancer drugs that can resensitize patients to subsequent cycles of therapy by erasing cellular memory and increase progressionfree survival by modulating the duration of druginduced arrest
exploring mammoth bone accumulations in central europe

the discovery of large accumulations of woolly mammoth remains together with upper palaeolithic artefacts has fascinated both researchers and the general public since the 19th century despite many years of scientific research and dispute our knowledge about these sites and the relationship between mammoths and contemporaneous upper palaeolithic huntergatherers remains incomplete this project focuses on the mammoth bone accumulations found in the west carpathian forelands and seeks to establish why they formed and their function for huntergatherer groups 3500025000 years ago a period of major technocultural and environmental change in approaching the last glacial maximum for the first time we will study materials covering the full chronological range of this archaeological phenomenon considering both existing collections alongside new fieldwork at the key sites of doln vstonice i krakw spadzista and langmannersdorf sitespecific signals of humanmammoth interaction within their local palaeoenvironmental context will be used to investigate chronospatial changes in both mammoth populations and huntergatherer societies we will employ standardised field and laboratory protocols that utilise recent methodological and technological advances in ancient dna research stable isotope studies radiometric dating palaeoenvironmental reconstruction and palaeodemographic modelling the resulting dataset will allow an integrated investigation of the formation of mammoth bone accumulations and produce a statistically analysable dataset expected to reveal the interactions between human and mammoth populations in central europe in the context of palaeoenvironmental changes this will have great impact not only for upper palaeolithic research in central europe but will on a general scale also contribute to an improved understanding of human behaviour cultural developments and human adaptation to dynamically changing climatic and environmental conditions
migralight effects of urbanisation and artificial light at night on the migration of a nocturnal bird

the itinerant lifestyle of migratory species makes them especially vulnerable to changes in environmental conditions understanding how migratory species respond to humaninduced changes in the environment is nowadays of paramount importance to conserve migratory species and the diversity of migratory behaviours in particular urbanisation and artificial light at night alan could have important impacts on migratory species urbanisation changes environmental harshness potentially offering new wintering areas with milder temperatures and higher food availability for migratory species alan modifies the airspace over which individuals migrate potentially fragmenting the sky and generating barriers for airborne migratory animals understanding how these two anthropogenic factors affect migration and its population consequences are now essential to anticipate the response of migratory species to anthropogenic global change combining expertise from the swiss ornithological institute switzerland and doana biological station spain this interdisciplinary project will investigate how urbanisation and alan affect longdistance bird migration and the evolutionary implications of such effects specifically this project will i identify differences in migratory behaviour between urban and nonurban bird populations ii test the effects of alan on migratory behaviour across a broad geographical range and iii determine the genetic population structure and connectivity of migratory populations exposed to varying levels of anthropogenic environmental pressure to address these questions this project will use a longdistance migratory owl the scops owl otus scops an ideal species to achieve the aims of this project the findings of this project have the potential to inform conservation plans for migratory species and the management of alan in cities
advancing knowldge for longterm benefits and climate adaptation through holistic climate services and naturebased solutions

increasing vulnerability due to climate change requires crosssectoral management of the territories with bottomup approaches based on active community participation climate change intensifies territorial risk and impacts severely on human migration and displacement particularly in subsaharan africa avoiding maladaptation associated to internal migration as well as to other adaptation actions which do not adopt a nexus approach eg waterfoodenergy nexus requires effective planning and management of migration hot spots at the same time it calls for more integrated strategies which simultaneously support sustainable development growth pathways and climate resilience development in the african context albatross aims at addressing these challenges by delivering novel innovative and decision makingrelevant tools and knowledge which will support the adoption of feasible effective and sustainable needbased adaptation strategies into af policies and programs it will do that by cocreating climate services and tools which will enable the weighting of compound and cascading impacts benefits and threats on ecosystem health food security socioeconomic vulnerability while addressing specific natural hazards eg drought or flood or sectoral climate adaptation needs eg agriculture through naturebased solutions nbs and other climate adaptation measures the methodological approach of albatross will be tested ad validated in different subsaharan countries leading to the cocreation and coevaluation with key stakeholders of needbased adaptions options and plans by combining participatory approaches with fundamental research grounded on the latest generation of observational data and modelling techniques albatross will provide robust and sciencebased evidence on the degree at which nbs may perform as multifunctional adaptation strategy for counteracting forced migration biodiversity loss and hydrometeorological risk in subsaharan africa
unlocking the hidden treasures of aquatic extremophiles sustainable development of industrially relevant novel active biomolecules

extreme aquatic environments account with a vast and yet largely unexplored biodiversity that holds immense potential for novel active biomolecules with multiple industrial applications however the harsh and challenging conditions such as accessibility environmental hazards ineffective or inaccurate sampling techniques and poor bioprospecting pose significant obstacles to their exploration and sampling overcoming these challenges is crucial for unlocking the potential of extremophiles to benefit society the explora project will depart from two extreme aquatic ecosystems selected such as the acidic rio tinto in spain and the psychrophilic antarctic region by developing innovative accurate and sustainable tailormade sampling methods employing cuttingedge bioprospecting techniques and utilising stateoftheart analytical tools for isolation of bioactive substances in the explora project it is expected to find and isolate microorganisms which produce novel antimicrobial and antioxidants compounds sialylated extracellular polymeric substances and plasticdegrading acidophilic enzymes which applicability will be validated for pharmaceutical cosmetic nutraceutical and for pet recycling purposes respectively additionally deeper understanding on the legal frameworks in the planned contexts such as the nagoya protocol and antarctic treaty legal requirements is also envisaged by achieving these objectives explora will contribute to the sustainable exploration of biodiversity hotspot regions advancing the development of nextgeneration sampling methods expanding bioprospecting from the screening for new chemicals into biological function and contributing to the understanding of potential tradeoffs inherent in the exploitation of ocean and other aquatic biodiversity
making contracts more human with stateoftheart natural language processing techniques in spanish

bounsel sl is a young innovative deeptech company that focuses its activity on the use of information technology it with the aim of offering in the form of a service saas a software platform for the intelligent and comprehensive management of contracts powered by a big data infrastructure and driven by advanced artificial intelligence techniques ai for this purpose the companys technological base is based on the application of machine learning and deep learning models based on cuttingedge natural language processing nlp techniques applied to the legal field and unstructured content in spanish and portuguese the company already has the platform on the market and its activity for the coming years will focus following the product roadmap on its rd strategy and the technicalfunctional improvements obtained from user feedback on the development of new functionalities based on software and ai for the intelligent management of contracts making them more humanlike so that a regular middle person can easily understand its content bounsel ai the business model proposed by bounsel is a transactional b2b saas that has different annual subscription pricing plans and with an international projection focused on south america bounsel has currently a team of 8 people and is located in the polytechnic city of innovation of the upv and maintains close collaboration with the technological institute of informatics iti the great relationship capacity of the founding team and its position in the legal tech market are exceptional the wide recognition in the ecosystem is also remarkable among others bounsel counts on the support of the womens institute the youth institute ivace cdti google for startups and the polytechnic university of valencia