Dragon09/odtu_chatbot huggingface dataset:
macroscopic active particles driven by light

in the last years there has been an outstanding growing interest in active matter in these complex systems a number of interacting agents consume and convert energy into mechanical motion representing nice examples of outofequilibrium behavior such systems are important because they can be found in nature ranging from the microscopic to the macroscopic scale eg molecular motors cells bird flocks or human crowds interestingly and despite the obvious differences among the agents that compose these systems common behavioral patterns have been identified such as collective motion anomalous diffusion segregation or clogging in the flow through constrictions aiming for a better understanding of these complex active systems a reductionist strategy is necessary and this is why the study of active granular matter very simple selfpropelled agents that interact uniquely by contacts is widely acknowledged within active grains we can distinguish between internally excited ones such as hexbugs or externally forced ones certainly the former have the advantage to closely resemble real active matter but to date also have the drawback of not allowing testing their response to external stimulus my proposal photoactive aims to fill this gap by designing novel macroscopic selfpropelled agents that are internally excited but can be driven by an external stimulus as it occurs with all natural systems the idea is to develop and implement hexbuglike particles whose source of energy comes from a photovoltaic cell the great advantage of these novel agents concerns the versatility that provides using a fully controllable illumination panel with which we can impose spatial intensity gradients or temporally evolving patterns in this way and applying an interdisciplinary approach involving experiments numerical modeling and simulations we ambition boosting the existing understanding of active matter systems
scalable knowledgeaware image caption generation

image captioning is the process of mapping a visual scene to a short textual description automating this process is vital for many computer applications including information retrieval from visual data computerized assistance to visually impaired people and automatic tour guiding stateoftheart captioning systems are limited by their heavy reliance on visual contents as a result generated captions are often purely descriptive and miss important information that is needed in order to understand the image this poc project develops a captioning tool that will be useful for knowledgeintensive areas like geography radiology or art history where captions need to include information that cannot be extracted from images alone it builds on results of the rocky erc adg project whose innovative captioning system integrates external knowledge into the captioning process this allowed the rocky project to employ standard methods of image captioning with a deep convolutional neural network cnn for image understanding and a transformer network for language generation thanks to the external knowledge integration the rocky captioning prototype gets substantially closer to humangenerated captions than standard captioning systems that do not take external knowledge into account this poc project will use this result by implementing a knowledgeaware captioning system that is scalable for practical purposes the project examines the feasibility of the rocky captioning method for medical imaging and art history and implements it for one of these domain as a use case the project will engage with experts in these domains specify a practical captioning system implement it as an opensource tool and test it in realistic situations the anticipated value of this effort is in the development of a general method that would allow one opensource platform to be multipurpose thereby costeffectively adjustable to needs of different domains
an odyssey without borders soil microbiota as drivers of plant species coexistence along successional gradients

our planet is in a biodiversity crisis to counteract biodiversity loss the eus biodiversity strategy for 2030 aims to protect vulnerable ecosystems reverse ecosystem degradation and restore biodiversity on agricultural land however successful restoration and conservation of plant diversity is hindered by limited understanding of the principles that govern the ability of plant species to coexist and drive plant diversity my proposed research aims to address the major challenge of restoration and conservation of plant diversity by examining how soil microorganisms contribute to plant species coexistence my project will draw together fundamental coexistence theory and stateoftheart knowledge from plant ecology microbial ecology and soil ecology to reconcile how pathogens and mutualists drive plant coexistence to develop successful strategies of conservation and restoration of plant diversity it is critical to define a single predictive theory on the role of soil microbes in plant coexistence i propose to reconcile pathogen and mutualistdriven coexistence hypotheses into a single framework by addressing two objectivesalong a successional vegetation gradient in which belowground interactions switch from pathogen to mutualist dominated i will 1 identify which pathogenic and mutualistic microbes plants accumulate with increasing intraspecific density and 2 determine how these soil microbes influence host plant coexistence results will uncover the role of pathogens and mutualists in driving coexistence and whether these different groups of players are mutually exclusive or act simultaneously this will lay the foundation for urgent tailormade applied research on the key processes that need conservation and restoration of grassland systems and uncover the drivers that steer plant community succession towards biodiverse ecosystems
realworlddata enabled assessment for health regulatory decisionmaking

the overall aim of the realm project is to create a collaborative framework for regulatory authorities application developers healthcare professionals and policy officers to cocreate and evaluate software for medical and healthcare use we propose to create an inclusive platform leading to a transparent ecosystem for evaluation and certification of software in healthcare where both the developers and the regulatory and health technology assessment bodies have access to a standardized set of technology stack and data this will be achieved by first mapping and analyzing regulations legislative efforts and guidelines from eu national bodies and around the world on software in healthcare practice these will guide the roadmap towards building an inclusive fair and multistakeholder ecosystem the scaffold for an integrated architecture will be developed in collaboration with darwin based on standardized data models and optimized data driven methodologies for the effective use of realworld data rwd in healthcare regulatory practice the architecture will consist of four components two technological infrastructures a living lab and a postmarketing surveillance module i a federated cloudbased data resources catalog will be established to bring together currently available rwd data and synthetic data to facilitate the data needs of the platform ii regulatory toolbox will be established to bring together standardized tools to train test evaluate and monitor medicalhealthcare software iii living lab environment for piloting medicalhealthcare software technology assessment taking into account humansoftware interactions as part of the system iv postmarketing surveillance with rwd for ensuring quality standards of the certified software in practice finally building on the proposed architecture five real medical device software mdsw projects are going to be implemented across 3 countries netherlands belgium and greece
store electricity and heat for climate neutral europe

sehrenes new electrothermal energy storage etes concept is designed to store renewable electricity re and heat and to restitute it as needed it is very energyefficient 8085 is geographically independant and uses no critical raw materials it enables 812 times longer storage duration than liion with lcos of 80 137 mwh depending on the usecase this is lower than pumped hydro the lowestcost commercial electricity storage its lifetime of 2030 years is 2 3x longer than liion a trl4 prototype and the digital twins of 3 full usecases will be delivered i ceramics plant storing excess onsite pv power in a microgrid and industrial wasteheat for continuous green h2 production and selfconsumption ii a smartgrid and iii a geothermal power plant the etes integrates i a novel heatpump design with a coefficient of performance of 50 the theoretical maximum ii a novel thermal energy storage system with energy density of 90 kwhm3 30 containing phasechange material in a novel metallic kelvin cellslike foam and iii orc with novel operating parameters new digital tools will optimise the energy management of the storage and facilitate investment decisions by potential endusers taking lca and technicoeconomic factors into account sehrene unites 5 rd teams with toplevel expertise in prototyping physicsbased modelling characterisation and digital twins of thermoelectric systems thermal storage and aibased energymanagement 1 re producer 1 dso 1 ceramics company 1 sme developing decisionsupport tools and 1 sme for dissemination and communication the exploitation plan aims to implement the solution in the first factory in 2029 sehrenes market penetration will enable to capture 1 of the market by 2040 avoiding 90mm3 of ng and 15mt co2year rd and industrial partners project to generate 58m in revenues by 2035 from sales of heat pumps thermal storage orc licenses to rd results and consulting services
interdisciplinary doctoral training on oligonucleotidebased therapies for myotonic dystrophy

rare diseases though individually infrequent collectively pose important challenges for patients clinicians and researchers in terms of diagnostics healthcare and treatment myotonic dystrophy dm the most predominant inherited muscular dystrophy in adults impacts 6000070000 individuals in europe its complex genetic and clinical variability result in a lack of robust genotypephenotype correlations which complicates the understanding of tissuespecific disease mechanisms the development of effective therapies and the stratification of patients into welldefined clinical groups for clinical trial purposes in recent years antisense oligonucleotides aso have emerged as promising therapeutics notably in neuromuscular disorders however previous clinical trials in dm have failed due the reduced efficacy and bioavailability of the aso tested entrydm aims to train 14 dcs in translational research through the combination of basic and clinical competencies across multiple disciplines as well as strong soft and transferable skills our interdisciplinary network seeks to enhance scientific and technological knowledge spanning from disease mechanisms aso design and delivery strategies to clinical trial preparedness using innovative multidisciplinary approaches and best practices the consortium includes experts in dm research bioengineering of model systems for preclinical drug screening aso chemistry as well as clinical and neuropsychological assessment close collaborations with multisectoral partners will address the challenges in technology transfer providing highquality benchtobedside training to the next generation of researchers through these efforts entrydm will catalyze aso therapeutic development towards upcoming impeding clinical trials establishing solid foundations for future clinical applications increased investment and entrepreneurship ventures in the field of dm and other related diseases
on rosalyn turecks legacy for bach performance in the 21st century

js bachs musical legacy is astonishingly rich we have been responding to his music for more than 300 years the american keyboardist rosalyn tureck 19132003 devoted more than six decades to performing researching teaching and writing about bachs works as well as music and arts in general she has left an abundant heritage on performance practice and scholarship for those who seek to understand perform and communicate bachs music this heritage remains mostly unrevealed bringing together efforts from music performance musicology aesthetic social studies new music technologies and composition the tureckbachxxi project aims at gathering exploring and questioning turecks ideas for bach performance in the aesthetic cultural social and technological mindset of the 21st century the main outcome of this project will be a commented edition of rosalyn turecks ideas and findings on concepts performance practices and techniques and stylistic prospects involved in the realization of bachs music and its connections with the music of today this will be useful not only to artist performers but also to musicologists composers and all enthusiasts interested in bachs legacy as well as for the evolution of music and the arts in addition this project investigates musicologicalperformance questions opened by rosalyn tureck that will bring new perspectives to performers as well as to researchers and bach enthusiasts finally the project questions the vitality and the longevity of a music of a past era in the technological cultural aesthetic and social environment of a new music era this will result in particular in a series of interviews with composers of today nourished with questions raised by rosalyn tureck testimonies about rosalyn tureck from the remaining people who worked with her will also be collected this interdisciplinary project opens new perspectives in the fields of bach studies and music performance
anion exchange membrane electrolysis from lowgrade water sources

anemel aims at the development of an anion exchange membrane electrolyzer that operates using lowgrade water sources such as saline and wastewater to produce green hydrogen using renewable sources the project will achieve this objective by focusing on the preparation of selective and efficient membrane electrode assemblies using noncritical raw materials as electrocatalysts and membranes the expertise of the consortium in oxygen and hydrogen evolving electrocatalysts membrane preparation reactorengineering and reactor modelling will ensure the delivery of an aem device capable to operate at low overpotentials without major water pretreatment and at a current density above 1 a cm2 the technical work will be compemented with an ecodesign process supported by an environmental and socioeconomic analysis to guide the development of a low impact and circular designed aem device maximising socioeconomic benefits a technoeconomic and exploitation plan to move from laboratory scale singlecell to a multistack electrolyser will be studied to ensure a fasttrack to commercialisation
development of novel strategies for alkyl organoboron preparation via boryl radical reactivity

borylated molecules are some integral tools routinely used to aid molecular construction in both academia and industry their use in the nobel prizewinning brown oxidation and suzukimiyaura crosscoupling as well as chanlam amination make them ubiquitous in organic synthesis the invention of methods to form cb bonds at sp3 carbons is of strategic importance to facilitate the preparation of saturated hence 3d molecules as the pharmaceutical sector is aware of the greater clinical success of 3d molecules developing methods able to prepare these materials is a topic of continuous scientific endeavour central to this quest is designing synthetic strategies able to deliver in a divergent manner building blocks that are stable and can be used in modular crosscoupling diversificationsthis project seeks to substantially expand the fields of photoredox catalysis and boron chemistry by introducing a novel class of boryl radical precursors that will enable the generation and the use of these underdeveloped species in mainstream catalysis this strategy will constitute a divergent platform for the generation of many novel 3d borylated molecules that will then be engaged in modular crosscoupling reactivity importantly this project will provide access to materials that cannot be prepared by any other methodthis research capitalizes on recent developments of the leonori group that has experience in the generation and use of boryl radicals in synthesisthe completion of such an innovative and ambitious project at rwth aachen university will be facilitated by generating transferring sharing and disseminating knowledge and will enhance my future career following the training plan envisioned
advanced manufacturing of drug substances by coprocessing with excipients through heteronucleation in a milifluidic device

pharmaceutical industry is starting to adopt the approach of continuous manufacturing with as few unit operations as possible to deliver drug products in a faster robust cheaper and sustainable way poor mechanical properties of many drug substances are a hindrance to this making them unsuitable for direct compression into tablets without additional operations this challenge can be solved by coprocessing joining the particles of such drugs to the particles of inactive substances known as excipients eg lactose normally used for tablets production the aim of this project is to develop a universal drugexcipient coprocessing cp platform based on surface crystallization or coprecipitation a cp method in a milifluidic device will be optimised with a range of drugs with differing physicochemical properties the relationships between them as well as excipient properties parameters of the method and structural and functional characteristics of the obtained composites will be thoroughly investigated to this end cutting edge techniques will be employed to analyse particle size morphology dissolution and mechanical behaviour to demonstrate improved manufacturability the prototype cp material will be used for direct compression and the tablets quality will be evaluated according to european pharmacopeia requirements the project will enable the researcher to achieve professional maturity in the field of particle engineering allowing to employ her skills both in academia and in pharmaceutical industry the results of the research will have commercialisation value being of interest to companies as a potential new platform in preformulation portfolio the project will contribute to the body of evidence informing the decisions of regulators on pharmaceutical coprocessing in the long term such impact should advance the transformation towards continuous manufacturing of affordable available and sustainable drug products
spatial communication and ageing across languages

spatial communication is fundamental to our species spatial terms including spatial adpositions and demonstratives are among the most frequent terms in languages and form the key connection between language and objectslocations in the world yet little is known regarding how spatial communication changes as one ages in later life and across different spatial scales and media the focus of scala is to understand fundamentally how spatial communication changes in typical and atypical ageing across spatial scales and how technology may be harnessed to afford enhanced understanding of spatial communication and support for spatial communication when needed in the context of an increasingly ageing european population this dn will train the next generation of scientists in the full range of multidisciplinary and crosssectorial methods necessary to make significant progress in understanding humanhuman and humantechnology spatial communication across time and scales with direct synergies between basic research and application training is structured around two interdisciplinary research themes spatial communication in typical and atypical ageing and spatial communication technology and ageing both involving systematic cosupervision and collaboration across sites with extensive interplay between academic and nonacademic beneficiaries and associated partners in turn we expect that a range of applications will be enhanced with increased usability and with associated societal and economic benefit the training of the cohort of doctoral candidate fellows follows innovative phd training approaches and will provide comprehensive interdisciplinary training embracing leading peer assisted learning methods that have been successively employed in previous dns this will produce a cohort of unique and highly skilled researchers ideally equipped to add significant value to both the public and private sectors
early warning of future rapid arctic sea ice loss

the arctic is currently transitioning toward a new climatic state that will be characterized by seasonally seaicefree conditions almost every year from the 2050s with widespread ecological climatic and societal consequences there is growing evidence that the future summer sea ice retreat will not occur at a constant rate indeed climate model simulations are suggestive of pronounced subdecadal fluctuations on top of the longterm trend leading to periods of relative stability followed by abrupt sea ice decline in hardly 35 years a lot remains to be understood regarding the precursors mechanisms predictability and impacts of these rapid events in particular it is unclear how close we might be to the next onethe overall objective of this project arcticwatch is to build an integrated early warning system that alerts on the possibility of rapid arctic sea ice loss for the following summer up to five years this system will provide annually updated assessments and will synthesize multiple lines of evidence harvested from various data sources preexisting and generated during the project including climate model projections initialized climate model and machinelearningbased predictions satellite observations and climate reconstructionsby introducing innovative targeted numerical experiments arcticwatch will also identify the new pathways of sea ice predictability in a warmer world and will thereby provide evidencebased guidance regarding the design of the arctic observing system for the next 30 years finally arcticwatch will make a leap forward in depicting environmental impacts during and after rapid sea ice loss events from short arctic heatwaves and precipitation extremes to long interactions with the arctic and north atlantic oceanic circulation timescalesthe hypothesis that after a decade of relatively stable conditions arctic sea ice is poised to an abrupt decline before 2030 will be paid utmost attention