Dragon09/odtu_chatbot huggingface dataset:
multiscale modeling of glassy electrolytes for solidstate batteries

new energy storage solutions are required for enabling a sustainable society solidstate batteries ssbs are promising candidates due to their safety and higher energy density compared to conventional batteries particularly the adoption of solidstate electrolytes with a disordered structure ie glassy electrolytes has garnered attention due to their superior ionic conductivity interfacial stability and reduced dendrite formation compared to crystal electrolytes however challenges related to brittle fracture scalable production and multiscale modeling impede largescale commercialization of ssbsthis project aims to establish a multiscale multiphysics model for glassy electrolytes in ssbs across varying length and time scales initially deep learning force fields for two glassy electrolyte families namely lithiumaluminumtitaniumphosphate and lithium thiosilicate will be developed based on training data generated using ab initio molecular dynamics work package 1 based on this largescale molecular dynamics simulations will be used to clarify the lithium diffusion and fracture mechanisms within the glassy electrolytes at the atomic scale work package 2 lastly a multiscale multiphysics model will be constructed by integrating finite element methods with macro atomistic ab initio dynamics simulations to simultaneously account for electrochemical reactions heat transfer and mechanical deformation work package 3aalborg universitys excellent research environment and the expertise of the fellow applicant multiphysics modeling and supervisor molecular dynamics glasses will ensure the achievement of the projects objectives and the broad dissemination of the findings by advancing theoretical insights into the behavior of glassy electrolytes the study will contribute to safer and more efficient batteries the fellow applicant will also emerge from the project with new skills and the ability to lead an independent research group
a leaky evidence accumulation process leap for consciousness

how we consciously experience the world remains a mystery in science to tackle this problem scientific works on perceptual consciousness contrast brain activity when participants consciously perceive a stimulus versus when they are unaware of it to report stimulus awareness participants need to make decisions however the extent to which the wellstudied mechanisms of decisionmaking apply to consciousness is unclear one possible reason is that standard neuroimaging methods lack the sensitivity to observe whether the mechanisms of decisionmaking also operate in the absence of task relevance as when participants become conscious of a stimulus irrespective of any task in this project i will test the hypothesis that a mechanism of decisionmaking evidence accumulation explains how perceptual consciousness unfolds over time first i will develop a computational model of a latent evidence accumulation process leap and test it on behavioral measures of phenomenal aspects of perceptual experience its duration and intensity second i will search for single neuron activity in humans that instantiates evidence accumulation and test whether it also determines these phenomenal aspects of perceptual experience third i will stimulate the corresponding brain regions to disentangle their causal role in either solely triggering perceptual experience or shaping it last i will use the leap model to explain hallucinatorylike experiences in patients with parkinsons disease and test whether deepbrain stimulation affects only decisionmaking as previously shown or also perceptual experience by combining computational modeling and cuttingedge electrophysiology the leap project will provide unique mechanistic insights on how neuronal activity determines perceptual experience and guides its temporal dynamics it will also provide a tool to better understand hallucinations which remain today a major debilitating symptom in numerous psychiatric disorders
delisoil delivering soil improvers through improved recycling and processing solutions for food industry residues streams

delisoil will adopt a multiactor transdisciplinary approach to codesign processes that minimise food processing waste and valorise its byproducts we will apply a circular bioeconomy approach to the waste hierarchy creating sustainable soil improvers in support of soil health in europe delisoils 5 regional living labs lls with actors along the entire food value chain will use innovative technologies to convert residues from food processing and production industries into tailored soil improvers research partners and companies will evaluate the soil improvers in stateoftheart laboratories and landowners will test the projects solutions the tailored soil improvers will be tested for stability biosafety and molecular parameters and their impacts on soil health agronomical performance and environmental risks will be evaluated environmental footprints will also be measured for selected products we will identify technological legislative financial and social barriers and enablers for the conversion of food processing residue streams into organic soil improvers and fertilising products and use these results to analyse fairness throughout the ll value chains together with stakeholders we will build communities and create networks to facilitate knowledge sharing of delisoils key exploitable results empower interdisciplinary design processes to improve soil health through the valorisation of food byproducts and increase societal soil literacy the living labs will share their solutions for using sidestreams from vegetable meat insect cultivation mixed food tomato olive oil and wine industry actors our proposed lighthouses will allow intereuropean partnering and demonstrate improved waste management sites integrating optimal practices in a circular bioeconomy framework we will work in close cooperation with other eu projects and the european soil observatory euso to ensure coordinated delivery of soil mission goals
the role of developmental biases on the tempo of phenotypic evolution

understanding the mechanisms that generate phenotypic variation and their impact on the course of evolution is a central challenge in modern biology the genetic architecture of development may limit or bias the phenotypic spectrum obtained after random mutation deemed developmental bias these phenotypic biases in turn may influence evolutionary trajectories despite the recognition of the importance of developmental biases in constraining and pacing evolution there is no direct empirical evidence for this potential role here i propose to tackle this key question using the ecologicallyrelevant avoidance to pathogens in the geneticallytractable organism caenorhabditis elegans to this aim i will i quantify and uncover mechanisms of developmental biases in avoidance behaviour and 2 test the role of developmental biases on the tempo of phenotypic evolution on the first objective i will generate a novel panel of random mutant lines containing a transgene for wholeorganism neuronal cellfate identification determine developmental biases in locomotor and avoidance behaviour and uncover mechanisms of developmental biases on the second objective i will construct hybrid outbred populations with varying developmental biases to test their impact on the tempo of phenotypic evolution in an ecologically relevant scenario using experimental evolution to achieve this i will adopt an innovative interdisciplinary approach that combines my expertise in neurodevelopmental and behaviour genetics quantitative genetics genomeediting and knowhow with the model c elegans with that of the host lab in experimental evolution behaviour ecology and hostpathogen interactions thus promoting an active exchange of multidisciplinary expertise between the two partiesevobias will elucidate the role of developmental bias during the evolutionary process and its mechanisms in an ecologicallyrelevant scenario and it will be a milestone towards my scientific independence
orbital engineering for innovative electronics

it has become increasingly clear that the european unions manufacturers largely rely on microelectronics components from outside the eu that make them vulnerable to materials supply bottlenecks to support eus hightech development and enhance its industrial sovereignty novel technologies engaging radically new concepts are required such as but not limited to spinbased electronics crucially these novel technologies must also demonstrate sustainability and resilience to material supply chain interruptions while at the same time reducing the environmental footprint of this growing sector obelix will contribute to this strategic effort by a twofold paradigm shift i harnessing the orbital degree of freedom shall bring disruptive solutions to existing spinbased technologies reducing power consumption and ii opening entirely new avenues for devices that do not require any heavy metals that are sourced outside eu and are often detrimental to the environment obelix will demonstrate how the orbital moment can be engineered and controlled using electrical as well as optical means enabling thus a novel information carrier that can be transmitted and used to write and read information thus outperforming conventional spinbased devices
training alliance for computational systems chemistry

many important questions and grand challenges in research industry and society involve large and complex networks of chemical reactions some examples are studying metabolic networks in humans planning and optimizing chemical synthesis in industry and research labs modeling the fragmentation process in mass spectrometry developing personalized medicine probing hypotheses of the origins of life monitoring environmental pollution in air water and soilin project tacsy we will develop groundbreaking new computational methods for analyzing such networks of chemical reactions and we will train a new generation of excellent and innovative early stage researchers esrs capable of evolving and applying these methods in research and industry combined these efforts carry very strong potential for impact on the grand challenges mentioned above on the eu commission priority on jobs growth investment and competitiveness and on the wellbeing of eu citizensthe research methodology of tacsy arises from the novel application of formalisms algorithms and computational methods from computer science to questions in systems chemistry the first steps demonstrating the strong capabilities of this approach have recently been made in tacsy the esrs will vastly expand these methods and their formal foundations they will create efficient algorithms and implementations of them and they will use these implementations for research in complex chemical systems in three flagship application areas tacsy is a consortium of worldclass experienced scientists which will ensure excellent research training conditions for the esrs in this highly interdisciplinary field through a carefully designed training programme and secondments at leading industry partners the esr will acquire a broad career perspective and a strong set of transferable skills their unique blend of competences from computer science and chemistry will further increase their high employment
personalised response monitoring in oncology cocreating clinical trials in advanced breast cancer

premio collabs vision is to prolong overall survival and improve the quality of life for patients with metastatic breast cancer mbc by providing refined guidance for managing response monitoring premio collab strives to facilitate improved patient care and streamlined clinical workflows addressing the needs of patients healthcare professionals and societyresponse evaluation methods for patients with mbc have not been modernised for decades although molecular imaging with fdgpetct has emerged as a highly accurate method for staging mbc and staging and monitoring mbc has a profound influence on treatment options and the chances of survival furthermore the patient perspective has rarely been considered although continuous response evaluation in a monitoring setting has interacted with the life of mbc patients for years still no specific recommendations are provided internationally for response evaluation in mbc or in the overall management of monitoring premio collab offers complementary competencies in an interdisciplinary collaborative effort to lift this complex task in a pragmatic multicenter randomised clinical trial rct we will apply the intervention of fdgpetctbased monitoring and compare it with conventional ct as stateoftheart the objectives are to analyse the impact of the intervention on overall survival and quality of life in patients with mbc and include costeffectiveness analyses directly informing hta agencies and health policymakers building on knowledge from the rct we will use participatory research designs to develop improved and modernised patient pathways and digital workflows aibased solutions in imaging and liquid biopsies constitute perspectives with a broader horizonthe work will be done in multiple european centres and living labs with patient representatives clinicians and relevant stakeholders aiming to provide knowledge for updated recommendations with a view to subsequent clinical implementationthis action is part of the cancer mission cluster of projects on diagnostics and treatment diagnostics
vortex enhanced liquid chromatography for hba1c monitoring based diabetes management in a globalized setting

diabetes is one of the main health risks today with near pandemic dimension causing blindness kidney failures stroke heart attack giving rise to very high health care costs 25 in the us and reducing the quality of life of around 500 million people worldwide the level of hemoglobin a1c hba1c is used to assess longterm glycemic control and is the best predictor for the risk of developing chronic complication of diabetes and appropriate follow up of the patients the golden standard is an expert laboratory hplc method focusing on hba1c quantification which has limitations when other relevant hemoglobin variants are to be detected for approximately 7 of the worlds population which are carriers of such hemoglobin variants current methods lead to under over or nonestimation of the hba1c fraction vortexlc will not only improve the quality of the analysis to give an instant full picture of the health status of diabetes patients it will also produce a cheap point of care device the use of vortex flows renders the approach compatible with mass manufacturing of plastic pillar array columns that are not only much cheaper than commonly used packed bed columns but wherein also higher separation performances can be obtained the polymer columns will be fabricated using uvnanoimprint lithography plasma technology to make them porous and add a chromatographic coating and lamination to close the column all processes that can be scaled to rolltoroll industrial manufacturing the columns will be embedded in an instrument that allows for integrated sample preparation and miniaturized uv absorption and sers detection allowing for both quantification and identification of analytes in the project a low footprint demonstrator of the novel system and columns will be built and tested with first synthetic next human blood samples to quantify hb1ac and its genetic variants
archaeology of dress along the middle nile

100 years of archaeological research along the middle nile has yielded partial knowledge of the history of sudan and nubia to date the focus has been on the public life of the sedentary elite other identities remain invisible and cultural frameworks tend to be restricted to binary oppositions eg sedentary vs nomads pharaonic vs african influences going beyond the monumental remains the fashioning sudan project will focus on a longneglected and much more intimate aspect of the sudanese material world dress practices this pioneering approach will merge different academic fields such as archaeology textile and animal skin research palaeoproteomics and sociocultural theory thanks to its arid climate sudan is one of the rare places on earth where archaeological textiles and skins are well preserved and in remarkably high numbers but despite its potential this treasure trove of information is seldom exploited by historians or archaeologists fashioning sudan will use garments as a privileged medium to reveal past identities bringing new and more representative knowledge about the populations of ancient sudan and highlighting the entanglement of dress practices in the fabric of society the project will encompass the highresolution analysis of textile and animal skin garments from the bronze age to the late medieval period in close connection with their archaeological context the results will reveal which animal and plant species were exploited as well as skills and craft dynamics it will then question how to use clothing and sociocultural theories to reveal previously unknown aspects of past sudanese lives fashioning sudan will renew our academic approach to past identities along the nile thanks to interdisciplinary research uniting underexploited material sources dress craft to innovative methods at the forefront of natural sciences and cultural studies
fair and inclusive twin transitions for a stronger social europe

fittereu fitter aims to contribute to existing research on the origins dynamics and determinants of inequalities and enable anticipatory governance to support a fair and inclusive twin transition in europe the project innovates by the formulation and development of an ecosystem fitter ecosystem that pivotally includes a highly interactive and gamified digital platform powered by an intelligent predictive decision support system through a cocreation methodological approach this ecosystem will enable policymakers to predict which social groups may be at risk of being adversely affected by twin transition policies under different scenarios with the option to simulate the implementation of these policies to assess inequalities and social exclusion risks the digital platform within the ecosystem will provide proposed mitigation measures and better practice guides that can be used to curve potential negative effects of policies on identified atrisk groups the fitter ecosystem also incorporates wider platform connectivity capability and better practice guides which through a foresight engagement process will help to meet the needs of the engaging fitter cluster community group of stakeholders ccgs the ccgs includes key paneuropean members such as policymakers civil society organisations including trade unions as well as business angels among other targets
scalable and ecofriendly bioproduction

core biogenesis uses plantbased expression systems for the very largescale and highquality bioproduction of pharmaceuticalgrade recombinant proteins the latter are used as growth factors gf in synthetic cell culture media for clinical and commercial scale biomanufacturing of cell therapy the company has developed a novel advanced proprietary bioprocess integrating breakthrough innovations overcoming major technical issues of plant systems by offering a 25fold yield increase and a 10fold cost reduction its biomanufacturing platform will enable core biogenesis to fully exploit the great potential of plants for large and scalable production capacity as plants are well known to be the most promising system for production upscaling core biogenesiss ambition is to position itself as the european leader in plantbased biomanufacturing by 2025
the role of tanycytic cilia in hypothalamic functions

obesity and metabolic diseases are a top priority challenge for health systems monitoring changes in the bodys energy levels is a task of the hypothalamus hpt which integrates the actions of peripheral hormones and nutrients with neural information however this regulation is complex and the causes and biological mechanisms leading to metabolic disorders remain to be explored among the cells involved tanycytes play a key role they are glial cells that line the third ventricle and mediate information about changes in the circulation to various hpt nuclei they regulate important neuroendocrine functions such as food intake and energy balance although tanycytes are known to integrate external and internal signals the specific cellular organelles through which they sense these cues remain unknown primary cilia pc are one such compartment crucial for perceiving peripheral signals and they are indeed present in tanycytes we have coined the name tanycilia for them however the function of tanycilia is still unclear here we hypothesize that cilia may act as antennae for tanycytes sensing nutrients or hormones enabling adaptive cellular responses and transmitting metabolic information to neurons this project aims to i characterize tanycilia morphology for the first time ii identify their functions primarily in the regulation of metabolism and iii examine them in pathological contexts like obesity and anorexia to achieve these goals we will employ immunohistochemical techniques to characterize tanycilia in wildtype mice to investigate their function we will genetically manipulate tanycilia using inducible mouse models in combination with tanycytespecific adenoassociated viruses raav the discovery of tanycilias roles in integrating peripheral signals to regulate neuroendocrine functions holds promise for understanding and treating metabolic disorders
awakening soil curiosity to catalyse soil literacy

curiosoil ambition is to trigger soil curiosity and create connections between people and soil in line with the eu mission a soil deal for europe curiosoil aims to contribute to transforming the way soil is valued perceived taught and communicated the project will build upon actual knowledge and will work to change the vision of soil from mere substrate to an ecosystem that should be researched and protected this will be achieved through the development of multisensorial soil experiences to raise soil literacy building of a soil optimism narrative and through the cocreation of a set of educational products curriculum standards and teachers training programmes the codesign and multiactor approach will promote student and citizen engagement in the mission soil as well as in other european national and international soil health initiatives and will incentivise behavioural change towards an increased perception of soil value and its sustainable use curiosoil will promote multilingualism and work in soil educational settings across 15 european countries in order to address the expected outcomes and deliver impact beyond the projects lifetime curiosoil will work across four impact pathways ip1 triggering soil curiosity ip2 prototyping multiple educational journeys to increase soil literacy ip3 empowering communities and initiatives dedicated to soil education ip4 influence policymaking through a soil optimism narrative
smart rna delivery for therapy and diagnostic

the progression of rnabased cellular applications in molecular therapy has been greatly hindered due the difficulty of delivering rna across biological barriers interest has therefore grown in the development of carrier systems which can facilitate rna delivery in a controlled manner herein we use peptidebased binders to stabilise and deliver doublestranded rna the main goals of this project are the identification of lead candidates with robust cell delivery in relevant cell lines and to be fit for partnering with a company andor securing followup resources