Dragon09/odtu_chatbot huggingface dataset:
magnesium and fetal metabolic programming an approach to preventing a lifecycle of metabolic diseases

obesity prevalence is increasing as well as the related metabolic alterations obesity and t2d increase the risk of pregnancy complication and affect offspring health through developmental programming effects obese patients with t2d frequently present mg2 deficiency during pregnancy mg2 needs increases and its insufficiency may affect the mother and fetus interfering with pregnancy development and offspring growth although it is known the relevance of mg2 its role in pregnancy is often overlooked and the underlying mechanisms that causes disturbances on mg2 homeostasis are unelucidated mg2 homeostasis is carefully regulated among the channels are the cyclin m 14 cnnm14 highly conserved molecules although it has been suggested that mg2 transport and homeostasis plays a key role in development its regulation during development and in maternalfetal communication is not fully understood fetal growth is closely related to the placenta capacity to transport nutrients and ions at birth the fetus makes a transition from using placental nutrient supply to utilize the liver thus changes in maternal liver metabolism related to mg2 levels and signalling could affect the maternal metabolic state and negatively impact the developing fetus this project aims to assess the role of mg2 homeostasis and transport through the cnnms in programming effects in the context of maternal t2d and obesity we will focus on the role of mg2 on fetal programming effects in a context of altered maternal metabolism and to evaluate the impact on offspring liver in addition we will evaluate the potential dietary intervention with mg2 supplementation for ameliorating offspringderived effects we hypothesize that maternal obesity leads to an altered environment that involves an impaired maternal hepatic mg2 signaling through the cnnms that affects the metabolic fetal environment and the maternalfetal interaction and programs offspring metabolic alterations
digid doing digital identities

we are witnessing the most significant change in statist identification practices since the consolidation of the international passport regime in the 19th century digital id devices like electronic id cards providing access to government services via pins biometric databases and blockchainsecured digital identity wallets are increasingly complementing or even replacing paperbased means of identification yet so far the implications of digital id devices have mostly been studied in relation to criminal suspects and migrant others not the normalized majority of citizens this project uses this unique moment of change to assess how material citizenship ie the technologies and infrastructures used to enact citizenship as a political subjectivity and a formal relation to the state is reshaped in the digital age its principal research question is how does the digitization of identification practices reconfigure relations between citizens and state authorities the project investigates transformations of citizenstate relations through digital id devices at three sites birth registration citizengovernment transactions and border controls theoretically the project draws on science and technology and data studies to propose a conception of material citizenship as performative and sociotechnical and to advance a research agenda that focuses on the practical epistemic political and ethical implications of digital identification methodologically the project combines multisited ethnographies textual analysis and mapping to study the design implementation and use of digital id devices in one international and four national case studies in this way digid sheds light on the muchneglected material dimension of citizenship and shows how digital id devices reshape the lived experience of citizenship understood as a legal status a form of membership in a political community and a set of bottomup practices enacting the right to have rights
bentcore liquid crystals tailored aggregates and nanostructures generated orthogonally

europe faces the imperatives of green and digital transition continually seeking novel nanoscale materials smart soft nanomaterials with their responsiveness to stimuli open a wide range of application to meet industrial and societal challenges while supramolecular chemistry enables tailoring captivating architectures and functionalities for the goal of closing researchtechnology loop bclctangos objective is to develop innovative functional soft materials through leveraging the orthogonal selfassembly dancing of bentcore molecules with focus on bc liquid crystals and tailored aggregates and nanostructures as well as on the exploration of suitable processing optionsin this marie skodowskacurie action dr maulovi will receive crucial training at the instituto de nanociencia y materiales de aragn inmauniversity of zaragoza under the supervision of prof maria blanca ros fundamental approach of organic synthesis and supramolecular chemistry will be used along with modern techniques of material and nanoscience to design and synthesize novel bentcore molecules 1 to broadly characterize them exploring functional properties suitable for application 2 and increase their real applied potential through processing 3 during 6 months of secondment at the institute for molecular systems engineering and advanced materials university of heidelberg under supervision of prof eva blasco she will explore a novel approach of 3d4d printing for some of these supramolecular materials as one of the processing methods this project will pave the way for the development of easily manipulable smart soft nanomaterials with tunable properties having a farreaching implication for industries in addition to promoting women education in stem the fellowship will have a formative and highly beneficial effect for dr maulovi enabling transition from a young researcher to a professional with a valuable set of scientific and transversal skills
the role of birds in sustainable urban subsistence at teotihuacan mexico

lessons from mesoamerican cities are wellsuited to address many problems with feeding urban populations today as large cities thrived in this region in the absence of large domesticated animals while we know that residents of teotihuacan consumed a plantheavy diet supplemented with wild animals harvested from local ecosystems and some husbandry of small animals like turkeys there are still many gaps in our understanding of teotihuacans food production system aviculture tests two hypotheses to better our understanding sustainable food production in the city 1 residents practiced lowintensity husbandry of turkeys and quails at the household level 2 aquatic birds a proxy for lake exploitation were more important to urban subsistence than current evidence suggests the project will test these hypotheses across multiple assemblages at the city by integrating common zooarchaeological analysis with proteomic analysis to improve taxonomic identification of bone and egg remains and examining eggshells to assess embryonic development the findings of this research will speak to the organisation of two important food production strategies for the city and highlight the importance of avian fauna and lacustrine resources in investigating the development of urban economies during the classic period
reliability and effectiveness of integrated alternative water resources management for regional climate change adaptation

recreate aims to improve the resilience of water supplies and protect the status of natural water resources by facilitating the assessment and inclusion of alternative water resources awr in water management planning for water scarce regions and to increase awareness and acceptance of and trust in the fundamental role of awr in climate change adaptation recreate will produce an open access repository compiling knowledge and data on the costefficiency environmental and health impact of different technological and water management alternatives this repository will be encoded as an independent module into a digital decision support framework recreatewt that together with 3 additional modules covering climate change impact predictions adaptation strategies to local context and a decision matrix will be used for cocreating adaptative pathways for water management recreatewt will compile and assess information on water availability and demand for a given region and organise knowledge on the performance of innovative treatment technologies it will explicitly consider human health risks associated to potable use local context regulatory cultural spatial and socioeconomical aspects and water management strategies under different stress scenarios the tool will provide a decision matrix for pathways creationthus recreatewt will act as a knowledge orchestrator and a decision theatre environment for codesigning water resource planning pathways recreatewt will be demonstrated in 4 regional case studies cs covering different bioregions mediterranean continental and atlantic and water contexts cs will focus on the digitalization of the water cycle for integrated water management while demonstrating the costeffectiveness reliability and safety of the use of new awr fullscale or already available pilots from previous or already ongoing projects will be used for recreate optimizing the efforts and maximizing the impact reached
hydrogen lightweight innovative tank for zeroemission aircraft

to enable a technologically and economically feasible h2powered aviation new integral lh2 tank solutions are required that could serve as part of the airframe main structure and capable of withstanding its respective loads the h2elios project will develop an innovative and effective lightweight lh2 storage system for aircraft it will be implemented as demonstrators in two fuselagelike cylinder section with approximately 19 m of external diameter and approximately 23 m of external length these demonstrators would be duly supported by component and subsystem ground tests at appropriate scale at project completion trl 5 at storage level the aim is that the concept is ready to be embedded and integrated in a specified aircraft architecture for flight demonstration in later stages h2elios will provide a feasible and novel lowpressure doublelayer composite tankbased system enabling the tank shape to be either conformal or nonconformal to the profile of the aircraft its general effectiveness will be assessed in terms of high gi performance and easiness of integration within the aircraft structurethis concept will be supported by latest evolutions of innovative methods and technologies in terms of multidisciplinary design development manufacturing processes and means of compliance and shall be demonstrated in operational conditions first on ground up to trl5 and then in flight by the end of clean aviation phase 2 clearing a trl6 maturation gate finally delivery to the market is expected in the 20302035 period in this way this project shall contribute to accomplish the objectives of the european green deal regarding decarbonization of the aviation industrythe activities of h2elios will be supported by explicit agreed support of easa and an external advisory board comprising commercial aircraft oems h2 management and cryogenics experts mro services airlines aircraft system integrators materials developers and suppliers and airports operation
sustainable membrane distillation for industrial water reuse and decentralised desalination approaching zero waste

melodizer implements highperformance membranes and modules in strategic applications of membrane distillation md hence providing the decisive step for the success of md these core components are fabricated with a focus on feasible wide uptake and on sustainability substituting harmful materials and protocols with 80 of benign solvents and relying on green chemistry principles both flatsheets and innovative hollowfibres are produced striking the optimum between productivity and energy efficiency as well as minimising foulingwetting phenomena also by applying novel sacrificial coatings while membranes are in situ optimised modules are developed with a focus on hydrodynamics and energy recovery improvements these activities are strongly supported by sustained modelling tasks conducted at different scales to i control the relationship between membrane properties and performance ii customise module geometry and iii increase system efficiency and automation the membranes and modules are thus rationally installed as core components of four md prototypes spanning three orders of magnitude of productivity two prototypes 25 m3day 052 m3day are demonstrated in industrial facilities textile beverage chemical industries to reuse wastewater 7090 thus reducing water footprint and approaching zero waste as well as to recovery valuable nutrients as secondary raw materials from aquaculture wastewater two prototypes 50100 lday 1020 lday are demonstrated as lowcost readytouse passive autonomous decentralised units delivering drinking water from saline and challenging sources at community and family level all prototypes are run with 90100 sustainable energy from waste heat andor solar energy with careful designs that maximise membrane and system performance quantitative robust evaluations of market entry and environmental benefits act as input data for each innovation activity in melodizer and to promote exploitation
the politics of love marriage migration and governance in spain italy and the united kingdom

at a time when migration is increasingly reduced to an object of state security pollov focuses on the legal political and most importantly affective relationship between state institutions especially those in charge of migration and migrants who are married to european citizens and who seek to regularize their legal status through the paired case of spain and italy southern border countries in the eu and the united kingdom a country that recently left the eu pol lov addresses the following empirical research questions how do state bureaucracies scrutinize evaluate and quantify love in their decisionmaking processes about marriage migration how do marriage migrants especially women experience these bureaucratic encounters by addressing these research questions pol lov pursues two main objectives 1 advancing social science theorizing about the role of emotions especially moral emotions in how state institutions operate and 2 improving our understanding of how the everyday encounters of marriage migrants with state bureaucracies affect meanings and practices and performances of romantic love across borderspollov is highly original and ambitious in its research design as it develops an interactional perspective focused on the relationships between the state and marriage migrants the methodology involves capturing state moral emotions through the classic anthropological tools of ethnography indepth interviews participant observation and semi structured interviews in practice this means interviewing policymakers lawyers and officials in embassies police headquarters and migration offices since there is a methodological focus on both sides of the encounters state bureaucrats and migrants i will also do participant observation and in depth interviews with marriage migrants and its partners and see how they navigate state suspicion and scrutiny
humancentric digital twin approaches to trustworthy ai and robotics for improved working conditions

ai4work will investigate practical methods and tools for optimal sharing of work between humans and airobots ai and robotics are likely to be most powerful means for radical improvement of working conditions in diverse domains as they can support human operators in diverse tasks starting from difficult and tedious manual labor tasks up to complex decisionmaking tasks the vision of the ai4work project is to improve communication and collaboration between humans ai and robots allowing for an improvement of the working conditions within different processes in organisations in several domains in terms of increased efficiency of work reduction in stress upon employees increased confidence in decisionmaking process etc due to the high level of uncertainty in modern organisations an appropriate balance between human and machine activities must be found the key assumption is that to cope with the required flexibility and dynamics sliding work sharing sws where this balance varies during the operation depending on the situational context machinebased confidence levels and human interactions is likely to be the most appropriate for modern organisations the key challenge of the project is to develop a set of common methods and tools methodology framework digital twin service platform sw building blocks for sws that can be applied in diverse sectors and with different airobotics services allowing for an effective experience exchange the project will make use of living digital twins of working systems as a mean to increase efficiency and trustworthiness of airobotics solutions by this the project aiming at improved quality of jobs and creating more decent work for human operators will contribute to the acceptance of the airobots support of work in diverse domains the project will be driven by six pilots in different sectors logistics manufacturing industry construction healthcare education and agriculture
investigating quantum stereodynamics in cold reactive scattering

it is a longheld dream of physical chemists to explore and ultimately control interactions between individual molecules and atoms at the full quantum level crossedmolecularbeam methods combined with recent technology allow for highlydetailed experimental studies of molecular collisions yet achieving fullycontrolled reactive collision experiments with predetermined outcomes still remains an immense challenge requiring control and detection of all relevant reactant and product parameters our worldunique crossedbeam setup combining zeeman deceleration and velocity map imaging would enable us to finally tackle this challenge when combined with recent cuttingedge technologies this setup has been used successfully to perform highresolution inelastic collision studies and we recently started investigating reactive scattering here i propose to perform the first fullycontrolled reaction experiment with predetermined outcomes to this end i will upgrade our setup to reach collision energies as low as 6 mk implement laser alignment for manipulating reactant orientations and employ 3d imaging for detecting product orientationsto achieve this aim we will first explore resonances and nonstatistical effects in the prototypical s h2 sh h insertion reaction to demonstrate our ability to reach low energies simultaneously we will laser align h2 molecules and employ 3d imaging in a separate setup to decipher molecular orientation stereodynamical effects in collisions involving h2 eventually all techniques will be merged for a fullycontrolled s h2 reaction experiment enabling us to dictate the reaction outcomeiqscores promises profound insight into the reaction stereodynamics at the full quantum level and the longdesired power to dictate reaction outcomes with exceptional precision thus providing an ultrasensitive test for theory this pioneering and groundbreaking research will thereby truly revolutionize molecular reaction dynamics
accurate and efficient ab initio quantum chemistry calculations on current and nearterm noisy intermediatescale quantum computers for relevant chemical problems

quantum computing has the potential to provide an exponential speedup compared to classical computers but the practical implementation is still in its infancytwo central questions are 1 in which field the current noisy intermediatescale quantum nisq hardware can provide benefits compared to classical computers and 2 which methods and algorithms enable this advantagethe aim of this project is to answer these questions by enabling accurate and efficient quantum chemistry calculations on current and nearterm quantum computers for relevant chemical and physical problems this paves the road to simulate strongly correlated electron systems of high scientific and economical interest where accurate approaches are needed to understand groundbreaking chemical and physical phenomena like hightemperature superconductivity photosynthesis or nitrogen fixation it will be achieved by developing and implementing novel quantum algorithms based on the combination of the transcorrelated tc methodand a complete active space selfconsistent field casscf embedding approachthe tc method will reduce the necessary quantum resources by providing accurate results for a small strongly correlated region already with small basis sets while casscf will allow to target more realistic systems by embedding the correlated region selfconsistently in a larger environment which is efficiently described by inexpensive meanfield approachesthis project has the potential to go beyond the stateoftheart by a pushing the boundaries of currently possible quantum chemical calculations allowing further theoretical understanding and practical design of quantum materials and b pave the road toward scientific and economical relevance of quantum computing already in the nisq era
reliable medical grade homebased test for selfuse for people with sleep disorders

sleep disorders are prevalent in 13 of the global population across various age groups and considered a public health epidemic nevertheless sleep disorders are often unrecognized and underreported these disorders can contribute to other medical problems and some may also be symptoms for underlying mental health issues sleep monitoring is essential for reliable diagnosis and improved management of sleep disorders currently sleep disorders are only measured during an overnight polysomnography psg however this method is limited in clinical implication due its unavailability high cost unnatural sleep environment and episodic brain patterns smart skin technology enables monitoring treatment efficacy the platform is designed to replace psg with homebased accessible technology the eic funding will enable xtrodes to optimize its platform and to perform the clinical validation activities necessary to obtain ce mark and start commercialization in europe