Dragon09/odtu_chatbot huggingface dataset:
postdischarge malaria chemoprevention in children with severe anaemia in benin kenya malawi and uganda formative and implementation research for policy decision making and implementation

background young children in subsaharan africa are at high risk of severe anaemia associated with high mortality children who have recently recovered from severe anaemia in malariaendemic areas remain at high risk of mortality for about 36 months after hospital discharge three months of postdischarge malaria chemoprevention pdmc has recently been shown to reduce hospital readmissions by 53 and postdischarge deaths by 77 who now recommends pdmc in all highly malariaendemic areas of africa however the optimal strategies for how to deliver pdmc are not yet clearobjective to undertake implementation research and translate results into national policy guidelines to promote pdmc uptake into clinical practice so that vulnerable children have access to lifesaving medicines study design i formative research in two countries in the process of adopting pdmc malawi and uganda and two not yet kenya and benin to identify key research questions for pdmc implementation ii two implementation trials benin and kenya n1824 in recently discharged children following recovery from severe anaemia codesigned with national stakeholders will evaluate at least two pdmc delivery strategies involving communityhealth workers and automated sms reminders the primary outcome will be adherence secondary outcomes include clinical and costeffectiveness and acceptability and feasibilityinterdisciplinary studies acceptability and feasibility costeffectiveness policy analysistimeline 42 months 9m preparationformative research 18m trial implementation 6m analysis 9m disseminationexploitation and phd completionimpact the project is designed to provide evidence to support pdmc implementationpartners institut de recherche pour le developpement france coordinating partner lstm uk epicentre france institut de recherche clinique du benin training and research unit of excellence malawi makerere uni uganda kenya medical research institute kenya
backboneoptimized oligonucleotides for therapeutics

therapeutic oligonucleotides ons have recently gained increasing importance as new drugs while conventional drugs are limited to targeting proteins oligonucleotides are able to target diseases upstream at the mrna level this specificity in combination with their easy design renders them highly valuable furthermore their applications are limitless involving treatment of socalled undruggable diseases the bottleneck in the development of new therapeutic oligonucleotides lies in the efficient synthesis of modified ons often these modifications require multistep syntheses and are laborious resulting in a timeconsuming process of drug development additionally these modifications often negatively impact physiological and biological properties in our proposal backboneoptimized oligonucleotides for therapeutics boost we outline a methodology for efficiently modifying oligonucleotides key to success will be the development of novel reagents capable of intercepting solidphase oligonucleotide synthesis due to their high reaction rate this will enable rapid evaluation of mono and multiplemodified oligonucleotides to assess their physiological and biological properties furthermore the introduction of multiple functionalities will become possible boost will serve as a new platform for designing therapeutic antisense oligonucleotides asos and sirna as a proof of concept we will evaluate the most promising modified oligonucleotides in biological settings
voice driven interaction in xr spaces

voxreality is an ambitious project whose goal will be to facilitate and exploit the convergence of two important technologies natural language processing nlp and computer vision cv both technologies are experiencing a huge performance increase due to the emergence of datadriven methods specifically machine learning ml and artificial intelligence ai on the one hand cvml are driving the extended reality xr revolution beyond what was possible up to now and on the other speechbased interfaces and textbased content understanding are revolutionising humanmachine and humanhuman interaction voxreality will employ an economical approach to combine these two voxreality will pursue the integration of language and visionbased ai models with either unidirectional or bidirectional exchanges between the two modalities vision systems drive both ar and vr while language understanding adds a natural way for humans to interact with the backends of xr systems or create multimodal xr experiences combining vision and sound the results of the project will be twofold 1 a set of pretrained nextgeneration xr models combining in various levels and ways language and vision ai and enabling richer more natural immersive experiences that are expected to boost xr adoption and 2 a set of applications using these models to demonstrate innovations in various sectors the above technologies will be validated through three use cases 1 personal assistants that are an emerging type of digital technology that seeks to support humans in their daily tasks with their core functionalities related to humantomachine interaction 2 virtual conferences that are completely hosted and run online typically using a virtual conferencing platform that sets up a shared virtual environment allowing their attendees to view or participate from anywhere in the world 3 theaters where voxreality will combine language translation audiovisual user associations and ar vfx triggered by predetermined speech
structureproperties of meltspun bioplastic fibers in correlation with their biodegradation behaviour and mechanical performance

polymeric textile fibers are one of the main sources of microplastics pollution in the open environment the european strategy for plastics in a circular economy acknowledges the need for increased rd on biodegradable polymers a key challenge of biodegradable plastics is that the biodegradation rate and material performance eg mechanical and thermal very often oppose each other it is therefore difficult to develop products that meet the performance requirements that users expect and still offer a substantial ecological advantage through fast biodegradation in the open environment it is of importance to the future health of humanity and the natural world that a wellperforming scalable and affordable biodegradable textile fiber will be developed as this is intrinsically difficult we need more fundamental understanding on how molecular design parameters eg chain stiffness and chain interactions and physiochemical properties eg crystallization influence biodegradation behavior on the one hand and fiber spinning and fiber performance on the other hand the key outcome of the project is a clear understanding of how we can influence the biodegradation of a fiber whilst having a good spinning process and fiber performance it is likely that besides understanding actual novel biosynthetic fibers will be developed in this project the applicant dr mohammadreza naeimirad is an expert in meltspinning of fibers and he is supervised by bas krins from senbis polymer innovations bv as the host organization and prof gertjan m gruter from university of amsterdam uva for the secondment senbis provides unique expertise and facilities on meltspinning and evaluation whereas the uva does so in the area of synthesis and biodegradation
green economy by digital and democratised energy markets enabling the active consumers

enabling the energy transition is an urgent measure needed to mitigate climate change however the integration of increasing distributed renewable energy sources is causing an imbalance between generation and demand grid congestion and price volatility it is crucial to digitalise the grid and empower the consumers to reduce the impact of these effects of the energy transition demand side flexibility dsf managed through new players that aggregate the offer of the consumers the aggregators is an innovative business model emerging in all the energy markets in europe the market opportunity is increasing at 215 cagr to reach an available market value of 167b in 2027 in the eu bamboo is a softwareasaservice platform based on artificial intelligence that allows aggregators and energy retailers to offer dsf in the energy markets in an automated and dynamic manner for the first time these industry players can predict the demand and the flexibility of their clients portfolio to offer it in real timebamboo will facilitate the easy creation of new companies that aim to enter the market of dsf as aggregators such as energy services companies infrastructures companies industry groups or energy communities therefore bamboo will significantly impact the digitalisation of the european energy system and accelerate the penetration of renewable energy sources in the gridthe company is cofounded and led by cristina corchero cto who is committed to bringing her knowledge and expertise acquired as a researcher to the market her professional career and female leadership has been recognised with outstanding awards moreover she has appeared on tv and media to talk about energy in plain language to the citizens thanks to women techeu cristina aims to improve her skills to manage the companys growth and prepare the businesss commercial and financial strategy for scalability
remotely actuated reshaped nanocarriers for tumour targeting

current nanometric drug delivery systems have enormous potential to shift clinical practice in diseases that require targeted or sitespecific therapy new tools to fabricating multifunctional drug delivery systems can potentiate drugcarrier activity and offer the necessary shift from inert carriers to active drug carriers that can maximize drug activity in the desired tissue this is particularly crucial in cancer where chemotherapy drugs have broad spectrum nonspecific activities based on our recent findings related to the role of physical properties of nanocarriers eg morphology shape and stiffness in cell specificity we propose to develop a remotely actuated nanocarrier with optimal parameters to provide tumor targeting the nanocarriers are composed of thermoresponsive polymer with metal which can be designed as asymmetric particles with preference of uptake by the more malignant cells the project includes the development of a novel methodology for fabricating anisotropic metalpolymer hybrid nanoparticles as well as characterization of their morphology and composition the remote actuation of the nanocarriers will be measured as well as their theopoetic potential the highrisk project can lead to an innovative approach in drug delivery with a particulate interest in cancer and other complex diseases
institutional changes for democratic dialogue

this project takes as its starting point the profound crisis that is affecting constitutional democracies all over the world the crisis is manifested both through a growing lack of confidence in constitutionalism and a dramatic increase in citizen dissatisfaction towards democracy the project is mainly motivated in that crisis and focuses on one of its causes the constitutional structure itself it is grounded on the acknowledgement that our constitutions were written in order to serve societies that no longer exist an obsolete political sociology and based on theoretical assumptions that we no longer share an elitist political philosophy this would explain the widespread feelings of civic disengagement that would be distinctive of our time and of which populist politics frequently take advantage in the face of the present crises numerous scholars have proposed weakening even further the democratic elements of our constitutional structure as if there existed a zerosum relationship between democracy and constitutional rights contrary to such views this project wants to make constitutionalism more sensitive to the increasing democratic demands upon it the project aims to offer concrete institutional alternatives devised to channel the demands of democracy and engage with activists and members of civil society in order to discuss and disseminate the projects outcomes for that purpose this project will first gather information on both contemporary constitutional reforms and the recent citizen assemblies movement
sensing predicting and exploiting consumer visual attention in fastpaced marketing environments

in the attention economy consumer attention is considered a finite diminishing quantity acting as a currency where brands compete to attract and maintain attentionbased marketing is a relevant emerging subdiscipline of marketing that studies consumer attention to understand and improve visual marketing stimuli marketing effectiveness and consumer behaviour by uncovering the fundamental interconnections between attention and action three main challenges in this area include how to a efficiently measure consumer attention in fastpaced environments eg in electronic marketing b optimise marketing stimuli for attracting consumer attention and c democratise consumer attention data eg eyesensing datafacial expressions for improving the experience of individual consumers while respecting their privacy at the same time inline with the abovementioned challenges the convise project will integrate insights from the marketing and computer vision disciplines to design methods for sensing predicting and exploiting consumer visual attention that can be used to optimise marketing effort and enhance consumer wellbeing in social media advertising settings first it will design videobased sensing technology for extracting reliable marketrelevant consumer visual attention maps minimising the necessary human sensor preprocessing effort next it will design tools for predicting consumer attention maps from the visual advertising content without using any sensors to produce objective advertisement evaluation metrics that can be employed during the visual advertising content design phase finally it will experimentally evaluate the developed consumer attention prediction technology from a consumer behaviour standpoint and will develop sensing data deidentification technology balancing between consumer privacy protection perceived ad relevance and ad intrusiveness
water distribution network efficiency optimisation with resilience and equity quantification

the proposal focuses on addressing critical challenges in water distribution networks wdn recognizing its fundamental role as an essential service for society the waterreneq approach is a comprehensive methodology that optimizes wdns by ensuring their response capacity to adverse events resilience guaranteeing equity for all users and maximizing energy savings the first objective o1 aims to establish a set of quantifiable indicators and performance indices that measure the operation of wdns these indicators will encompass key aspects of resilience and equity while focusing on energy efficiency as a quantifiable metric objective two o2 focuses on the development of an innovative mathematical model this optimization model will calculate the indices defined in o1 within a wdn it will provide a practical methodology to evaluate and analyze wdn resilience addressing both operational aspects and overall system performance the third objective o3 targets advancements in the computational efficiency of optimization algorithms this involves reducing the number of discrete variables and optimizing the overall search space improving computational efficiency is crucial for solving complex realworld optimization problems effectively objective four o4 involves the development of an optimization tool that proposes investment strategies for wdns the tools primary goal is to maximize resilience and equity indicators within the network even when budget constraints are present this approach aims to provide a robust mathematical framework that considers resilience and equity criteria in summary the proposal addresses fundamental challenges facing wdn by introducing an innovative approach to measure and improve resilience equity and energy efficiency developing a computational tool that can be applied to realworld scenarios once the tool will be validated in a benchmarking network this will be applied on a real wdn in a wter supply company
green alternatives for european autonomy challenge

contemporary entrepreneurial ecosystems in the ris eit regional innovation scheme countries largely remain underdeveloped with moderate innovation capacity a fact often evidenced by the brain drain of local talents the numbers of entrepreneurial student teams and consequently the innovation development level in ris countries are still relatively low the operation of 7 incubators of eit rawmaterials since 2019 in ris countries has validated this insufficiency and the lack of uniformity of the national entrepreneurial ecosystems indicating the need for enrichment and support for organic growththe proposed project green alternatives for european autonomy gaea challenge outlines the implementation of a coherent program for youth employability to reinforce regional entrepreneurial ecosystems by engaging students and local talents in regional and interregional idea competitions building on the successful experience of the greentech challenge in greece gaea will go beyond the current stateoftheart a by widening the conceptual scope of challenges to address to include the dimension of the european autonomy reinforcement within an international context influenced by the war in ukraine and b by interconnecting regional ecosystems in a crosscultural initiative designed to last beyond the 28 months period of the projectgaeas ambition is to enhance entrepreneurial skills of youth in moderate innovation ecosystems by bringing together educational institutions private companies in a mutually beneficial way ultimately boosting entrepreneurial ecosystems growth in eu countries that mostly need it the project will unfold in two stages regional interregional mobilizing and connecting regional entrepreneurial ecosystems around student ideas and projects that will reach to the market in eight countries el lt sk lv hu cz se rs and pl improving innovation flows among the regions and consolidating this knowledge through accelerated projects
assessment of the potential of a smart energy router based on the superheart technology for vertical farming

vertical farming is a promising technology to address the challenges related to the impact of climate change on agricultural production the increased demand associated with global population growth and urbanisation however vertical farms are energyintensive plants with specific requirements the technology and systemlevel design and control optimisation developed in the eic transition project superheart involves research and development on multiport power converters their unique features such as the high density low loss and fault tolerance can address the specific needs of the application the aim of this project is therefore to provide a systemic and systematic benchmark assessment of the costs and benefits of the technology developed in superheart for the supply of vertical farms
investigating aspects of metabolism pertinent to atherosclerosis utilizing computational techniques

cardiovascular disease cvd claims 179 million lives and costs the european economy 210 billion annually new innovative strategies are needed to address this health crisis impact takes a systems medicine approach to extend our understanding of the factors that contribute to cholesterol metabolism and to develop innovative therapeutic approaches for atherosclerotic cardiovascular disease acvd impact has three objectives 1 develop an lp algorithm that analyzes models of human and microbiome metabolism to identify optimal microbes and nutrients that may influence metabolic pathways of interest 2 develop a detailed model of cholesterol metabolism that is trained and validated using human data by synergistically merging fba models with an ordinary differential equation ode model of cholesterol transport simulations and statistical analysis on the insilico results will be conducted to identify metabolic pathways related to acvd and to investigate how variables such as microbiome composition sex obesity and diet influence cholesterol metabolism and acvd risk 3 metabolic pathways related to acvd risk will be targeted by the lp algorithm to identify optimal microbial and nutritional therapies that can treat andor diminish the progression of acvd promising bacterial strains and nutrients will be tested with invivo gut simulators in an intersectoral secondment with international flavors fragrances inc results of the proposed research will be effectively disseminated and exploited to maximize impact while the action serves to extend the stateoftheart and address a health crisis impact will simultaneously expand my technical knowledge and transferable skills bolster my credentials and enhance my career competitiveness through intersectoral exposure
deciphering evolutionary innovations comparative genomics of the origin and loss of venom in marine snails

the venorign project aims to understand the evolution of novelty in biology a major goal of contemporary evolutionary biology is to decipher the molecular basis of major phenotypic innovations in organisms such as winged flight in birds and echolocation in whales however most cases of evolutionary novelty involve complex interactions among multiple genes each with only minor effects to address this challenge we turn to venomous marine snails specifically the conoidea group which includes cone snails and related species venom in these snails is linked to a limited set of proteins called toxins representing the primary genetic changes responsible for the shift from nonvenomous to venomous animals the longstanding interest in cone snail toxins provides a unique context for studying this transition yet the origins of the conoidean venom system and the processes governing multiple venom losses remain poorly understood this project tests the hypothesis that the origin and loss of conoidean venom resulted from rapid genomic and morphological changes and will investigate these genetic and morphological alterations driving venoms emergence and disappearance using cuttingedge methods spanning morphology taxonomy genomics and transcriptomics we will analyze venomous and nonvenomous conoidean and related species this comprehensive comparison will reveal the processes governing venom acquisition and loss shedding light on the principles of evolutionary novelty our work extends beyond venomous snails offering a novel model to understand the molecular foundations of significant evolutionary changes these findings will contribute to our understanding of how novel traits emerge in various biological systems including human pathogens and agricultural development