Dragon09/odtu_chatbot huggingface dataset:
the power of size how crossdisciplinary scaling transforms assessment and management of environmental risks

settingover the last decades anthropogenic pressures on the environment have dramatically intensified and diversified nowadays we have to deal with 100000 pollutants species and sites to set the right priorities among these environmental problems and to select the best alternatives among sustainable solutions proper assessment tools are urgently neededrelevancewhile several models are available application to thousands of cases is severely limited by data gaps due to financial ethical disciplinary and other constraints as an alternative missing information can be obtained by linking parameters to size eg catchment area organism weight while scaling has been proven valuable for a few parameters relationships have been derived in a monodisciplinary context onlyobjectivesfollowing the urgent scientific and societal needs the overall aim of powerofsize is to obtain a crossdisciplinary suite of mechanistic and statistical relationships for environmentally relevant parameters quantities in assessment models as a function of size and other descriptors underpinned by overarching scaling principles based on research gaps and policy priorities we focus on pollutants covering emission and fate in catchments and cities accumulation in organisms and effects on communitiesmethods expected results and impactbased on information from reviews databases and articles we will derive empirical and theoretical relationships for rate time density and other quantities y parameters as a function of city catchment organism and community size x covering eg water in catchments materials in cities blood in organisms and biomass in communities as well as the pollutants they generate carry and degrade identifying overarching principles based on shared system characteristics eg dimension the integrated suite obtained 1 profoundly advances our understanding and 2 crucially reduces datahungriness of assessment tools
neanderthal virtual bone histology deciphering hominin growth rates activity and environmental adaption

a central challenge in the study of the history of humanity is to understand how evolution has shaped who we are today neanderthals are our closest relatives in the human evolutionary family tree therefore understanding the differences and similarities between neanderthals and anatomically modern humans amh is crucial for defining our phylogenetic history bone palaeohistology the study of the microstructure of fossilized tissue offers scientists a window into the past mineralized tissue keeps a record of an individuals growth and adaptive responses therefore allowing us to study aspects of life history long after fossilisation due to the rapid increase of cuttingedge technology of virtual histology we can image the internal microstructure of bone without inflicting damage to the material this allows for the highresolution study of important fossils including those of early humans although of such high potential bone histology is still a highly understudied field in human anatomical evolution in this project i combine advanced xray techniques synchrotron and labbased phasecontrast microtomography synchrotron xray fluorescence and infrared spectroscopies with the investigation of a large sample of skeletal elements from the krapina neanderthal collection dated 130 10 kya croatia to investigate detailed aspects of their developmental biology i will do this by 1 establishing the preservation state of the neanderthal fossil remains 2 examining the speed of maturation of juvenile neanderthals and 3 assess the type and intensity of neanderthal physical activity and environmental adaption finally i will employ the newly acquired knowledge and skills to valorise the 3d modelling of fossil bone microstructure for museum and outreach purposes in commercial settings the results of enigma will significantly contribute to our understanding of neanderthal biology and with that help us to further define what it means to be human
individualised care from early risk of cardiovascular disease to established heart failure

the burden of cardiovascular disease cvd on society is huge with 85 million people affected in europe the overall prevalence continues to grow due to unhealthy lifestyles and population aging heart failure hf is the final common pathway of all cvd and has a 5 year mortality rate of 2050 despite significant advances in therapyicare4cvd aims to address this burden by contributing to three essential steps to improve the current care pathways covering all stages from early risk to established hf 1 early diagnosis to identify patients at risk of cvd and divide them into clinically meaningful subgroups 2 risk stratification for these subgroups to define the urgency for intervention and 3 prediction of treatment response for each subgroup this will be achieved by the following steps clinical partners will provide a large set of cohorts including 1000000 patients with a wide range of biomarkers eg digital blood imaging anonymous access to data will be enabled by using a blockchainsupported federated database artificial intelligencebased modeling also considering patient relevant factors will assess changes in risk and stratify patients according to their individual responses to therapy results will then be prospectively validated in new and ongoing large cohorts and a pilot trial to test the prediction of treatment response by using multiple biomarkers going beyond current risk prediction such as score towards individualized therapy results will be used to provide novel decision tools for each step targeting newly identified subgroups and as a blueprint for innovative future trials to individualise prevention and therapy patient involvement is key in every part of icare4cvd eg patient advisory board to build a motivational framework for selfcare by patients the project brings together an euwide consortium with the needed resources and expertise from the public and private side to bring icare4cvd to success
neurovascular coupling and neuronal infraslow activity

cerebral autoregulation and neurovascular coupling have a critical role in sustaining brain activity and preventing irreversible damage yet despite revolutionary advances in neuroimaging methods questions remain on the relation and reciprocal interactions between cerebral hemodynamics blood flow oxygenation vascular regulation and neuronal activity narnia aims to unravel this intricate relationship and pushes the boundaries by developing a highspatiotemporal resolution multimodal cortical neuronal activity and hemodynamics imaging system using 3264 channel graphenebased solution gated fieldeffect transistors gsgfet and new highdensity speckle contrast tomography this system will study both spontaneous and electrically evoked activity in the cerebral cortex uniting neuroscientists engineers and physicistsas an experienced researcher with a background in developing highspeed aline rate swept source modelocked lasers and interferometers for optical coherence tomography oct i have a deep understanding of the intricacies of optical imaging systems my work includes combining multimodal biomedical imaging systems gabor domain optical coherence microscopy and multichannel scanning confocal fluorescence microscopy demonstrating my ability to bridge various technologies and methodologies this endeavor will significantly expand my skills research capabilities and network ultimately advancing my career as an independent researcherby gaining a deeper understanding of these processes in the long run we envision contributing to the development of targeted interventions that can improve the quality of life for 125 eu population suffering from conditions like alzheimers parkinsons stroke etc a fundamental understanding of this relationship will allow us to propose new hypotheses towards newer diagnostic and therapeutic approaches potentially offering earlier diagnoses and more effective treatments for these neurological conditions
developmental immunotoxicity of perfluoroalkyl substances pfass in a population of highlyexposed children

exposures to perfluoroalkyl substances pfass a class of persistent chemicals have been linked to an array of adverse health outcomes including reduced antibody response to vaccination the covid19 pandemic has focused attention on the serious implications of pfas immunotoxicity however there is a lack of epidemiological studies on clinical immune outcomes eg infections or asthma in children whose developing immune system is highly sensitive to chemical exposures this proposal pfasitox addresses this research gap by leveraging a unique cohort of children with a wide range of pfas exposures background to highly exposed and detailed medical records to investigate the potential immunotoxic effects of prenatal and childhood pfas exposures on clinically relevant outcomes including covid19 incidence it was discovered in 2013 that one of two municipal water supplies in ronneby sweden was delivering water that was highly contaminated by pfass from firefighting foam runoff at a nearby military airport earlier studies in ronneby found that serum pfas concentrations corresponded closely with residential address history allowing residential history to be used as an accurate proxy for exposure pfasitox uses this natural experiment to create a longitudinal cohort of children and evaluate whether high pfas exposures are associated with clinical outcomes related to immunosuppression eg counts of common childhood infections and hypersensitivity eg incidence of asthma while existing studies of pfas immunotoxicity rely on selfreported data or hospital admission records i will use the skne healthcare register unique to southern sweden to identify outcomes at all levels of care including primary care where many immune outcomes are diagnosed the proposals results will inform future pfas research provide necessary evidence for risk assessments and provide critical information to health practitioners caring for highlyexposed individuals
microfoundations of collective defence

does the success of military alliances ultimately hang on the whims of public opinion the historical record shows that allied states often do not honour their collective defence commitments but existing scholarship has not yet explained the role of public views in these highstakes decisions the microcode project aims to initiate a new research agenda on the microfoundations of collective defence that puts public opinion in allied countries at the centre of inquiry building on cuttingedge approaches in experimental political science international relations and political psychology i aim to conduct an extensive crossnational investigation in the key nato member states with the views of individuals as the principal unit of analysis i introduce a complex theoretical model to explain 1 how individuals form attitudes towards allied assistance in different collective defence scenarios 2 how these individual attitudes aggregate to form public opinion shaped by societal cues and 3 how in turn public opinion shapes the views of decisionmakers in allied states my main set of hypotheses concerns the critical impact of the strategic context on the formation of public opinion and its relevance for policymaking i propose that whereas conventional scenarios of direct armed aggression leave a limited role for public opinion the more ambiguous grey zone conflicts potentially open a wide contestation space where public views become more polarised elastic and simultaneously more relevant for decisionmakers as a methodological innovation i will use novel immersive mixedmedia experiments to create an interactive engaging and realistic experience for the participants and examine how their attitudes towards defending allies change under different conditions at a time of dramatic deterioration of the international security environment the microcode projects findings could redefine how we view the stability and credibility of military alliances
antiferromagnetic spin transport with relativistic waves

while photonics has already enabled nearly lossless tbs transfer of data using light waves computing at thz clock rates is the next monumental challenge magnonics which employs spin waves sws instead of light waves is widely seen as one of the most appealing solutions to this problem but so far only operates at ghz rate interference of sws enables nearly lossless protocols for logic operations the large natural nonlinearity of sws can be used to control their mutual interaction propagation and manipulation of magnetic bits altogether facilitating the concepts of transistor and logicinmemory devices since the wavelength of thz sws is orders of magnitude shorter than that of thz photons thz sws offer enviable scalability down to the nanoscale how to push magnonics into the thz domain and enter the nonlinear regime how large are the thz nonlinearities answering these questions will open up new avenues to scalable technologies for thz and nearly lossless computingwith astral i want to enter the nonlinear regime of thz magnonics by generating ultrashort large amplitude sw pulses that similar to femtosecond laser pulses in optics can zip undisturbed over long distances unlocking the nonlinear regime of interaction between the pulses other sws and even macroscopic spin textures i propose to focus on antiferromagnets where sw frequencies can easily reach the thz landmark and similar to light waves in vacuum follow a linear socalled relativistic dispersion relation owing to this a broadband wavepacket of coherent sws can be compressed to an ultrashort sw pulse a bunch of fewcycle largeamplitude spin oscillationsto achieve this astral will exploit the exclusive ability of light to initiate ultrafast spin dynamics and will attempt to interconvert femtosecond laser pulses into largeamplitude ultrashort sw pulses although the idea is fundamental in nature the ambition is to set the ground for revolutionary new computing technologies
modelbased engineering of digital twins for early verification and validation of industrial systems

thanks to the advances in information technology modern industrial systems are becoming increasingly intelligent and autonomousthus their requirements for eg correctness availability traceability and reliability are also increasing monitoring analysis anddiagnosis of such industrial systems became pivotal and fueled the development of virtualization and simulation solutions such asdigital twinsin a nutshell digital twins are virtual representations of actual systems or processes that serve as realtime digital counterparts foreg prediction analysis testing and simulation developing digital twins is a complex process on the one hand it includesdeveloping digital twins at different levels of abstraction of the system to allow one to focus on different relevant aspects egbehavioural logical physical on the other hand it must ensure the correctness of digital twins with respect to the systemspecifications and the respective level of abstraction and the federation enabling the communication between digital twinsconceived as exchange and resume of modelsthis project aims to develop a modelbased framework addressing the abovementioned challenges by i automating the creation ofdigital twins for the simulation monitoring and testing of functional and nonfunctional properties ii continuous validating digitaltwins to meet the required properties and iii developing a multidomain and automated digital twin toolchain for the verification andvalidation of complex industrial systems based on digital twins we foresee that this project will positively impact the efficiency ofsuch systems by reducing their time to value and by increasing their final quality
beyond xylella integrated management strategies for mitigating xylella fastidiosa impact in europe bexyl

bexyl will contribute to promote research and innovation and specifically provide interdisciplinary solutions according to the demand of the stakeholders embebed in the project contributing to deliver specific impacts for each of the expected outcomes as foreseen by the horizoncl62021farm2fork0104 call in line with the conceptual approach of the new eu plant health law bexyl has been conceived to strengthen the two pillars of plant protection i prevention and ii control strategies for the priority quarantine pathogen xylella fastidiosa xf the workplan is designed to assess the risk of new xf outbreaks in the eu under changing climate wp1 improve the methods for border inspections and surveillance for early detection wp2 ensure the phytosanitary standards for the trade of plant propagation materials using nonchemical treatments wp3 restore outbreak areas based on the strategies to improve host plant resistance wp4 and disease management tools ie decision support systems and ipm protocols in conventional and organic production wp7 based on investigations for the control of insect vector populations wp5 and innovative biological tools for xf wp6 outbreak management approaches will take fully into account the ecological and socioeconomic contexts for their adoption and implementation wp8 in line with the eu green deal for a transition to environmentally sustainable healthy and resilient agriculture and forestry bexyl will support research innovation and transfer of knowledge wp9 for crisis preparedness to help to prevent new xf outbreaks and further spread of currently infested areas as well as to support agriculturalforestry sectors for remaining productive in outbreak areas
largescale multipartite entanglement on a quantum metrology network

hundreds and thousands of fireflies synchronize their dazzling light in summer nights one of natures most beautiful demonstrations on the importance of synchronization and scalability in a network so we ask the question is it possible and even necessary to synchronize all components in a complex largescale quantum networkthis is not a question for the future rapid experimental progress in recent years has brought first rudimentary quantum networks within reach highlighting the timeliness and need for unified frameworks this proposal minet aims to establish a unified framework on time both experimentally and theoreticallysimilar to a classical network a future quantum network may have to attach accurate timing stamps to all events occurred such as the generation and storage of qubits however entanglement swapping which will be used to scalably connect a large ensemble of quantum nodes puts a stringent requirement on this timing task making it beyond todays technologiesminet will build a largescale multipartite entanglement testbed connecting two science cities in north germany hannover and braunschweig taking advantage of the latest metrology advances minet will use a telecom fiberbased optical clock network to disseminate ultrastable timefrequency information to devices in three remote laboratories in the two cities the important requirement on scalability on the other hand will be provided by semiconductor quantum dot sources that have incredible improvement recentlythis project is at the forefront of semiconductors quantum communication and metrology minet will be the first of its kind allowing one to gain the full advantages of available resources within a clocked quantum network in the long term the fiberbased optical clock network as part of a paneuropean collaborative effort may help to synchronize a large number of quantum computing and communication devices at large scales that can never be reached before
erbium ion quantum register operated with a single microwave photon detector

erbium ion embedded in crystal is a promising candidate for quantum information processing for its unique properties such as optical transition at telecom band and large magnetic dipole erbium nuclear spin has long coherence time and is ideal for working as quantum memories a hybrid quantum register formed by erbium electron spin intrinsic nuclear spin and nearby nuclear spins in the host crystal combining fast control highfidelity readout and long memory time will have huge capacities in quantum applications such as quantum computing and quantum communication previous spinbased quantum registers rely on the spindependent photoluminescence which is system specific in this project we propose to realize erbium ion quantum register operated with a single microwave photon detector which is based on a superconducting transom qubit and works in principle for any spin system this project will enable interface between quantum register and microwave photons and pave the way for more sophisticated quantum applications of erbium ions longdistance spinspin entanglement and hybrid quantum information platforms
boosting europes sustainable battery cell industrial manufacturing value chain by developing an optimised machinery with intelligent control processes to minimise costs scrap and energy consumption

the core vision of the batmachine project is centred on strengthening europes battery cell industrial manufacturing value chain by developing new battery cell manufacturing machinery this is done whilst giving priority to minimising the energy energy for cells production enhancing plant efficiency rates and integrating intelligent control processes to reduce scrap batmachine will develop and implement an optimised and energyefficient process chain considering slurry mixing automated modular process setup including monitoring techniquesexclusive slotdie coating and drying novel machinery with one side coating a coating speed of 1mmin up to 20mmin and a webwidth of 300 mm together with a calendaring tool to be integrated in a battery manufacturer for process optimisation moreover intelligent control processes and industry 40 will be intensively integrated through the creation of a collaborative and fair data space for battery production digital interfaces between battery manufacturing equipment control system and engineers will be developed with the aim of building universal digitalisation tools to enhance the battery production and create a battery passport the environmental and economic impact of different machinery production line configurations and factory designs will be deeply studied to reduce the cost and energy consumption of manufacturing processes