Dragon09/odtu_chatbot huggingface dataset:
engineered exosomes for stimuliresponsive imageguided drug delivery for cancer theranostic applications

the primary objective of this project is to engineer a nonimmunogenic cellmembrane mimicking drug delivery vehicle for remotecontrolled precision drug delivery this will be achieved by encapsulating stimuliresponsive contrast enhancing nanoparticles and drug cargo into endogenous exosomes to develop a therapeuticcumdiagnostic exosomal system viz theranoxome for imageguided stimuliresponsive drug delivery such biomimetic theranoxomes if realized will have wide applicability as a universal drugdelivery agent the project entails three steps 1 synthesizing theranoxomes by template assisted loading of chemotherapeutic drugs light responsive thermoplasmonic gold nanorods and magnetic nanoparticles as magnetic resonance imaging agents into exosomes 2 biophysicochemical characterization of theranoxomes including colloidal properties biomimetics immunocompatibility lighttriggered drug release magnetism imaging and magnetic guided enrichment and in vitro studies 2d and 3d cell cultures 3 application of theranoxomes in vivo in a breast tumor bearing mice model i the er will prepare characterize and test the materials and application proposed with the support of a multidisciplinary hub of specialists the prime training aim of theranoxome is to provide me with a solid foundation in biomaterials which will support my future career endeavours both in the academia or industry to be an independent researcher a founder of a startup company or to become key player in the biomaterials sector i will be hosted by the centre for research in biological chemistry and molecular materials ciqus of the university of santiago de compostela a cuttingedge multidisciplinary research centre at the interface of chemistry biomedicine and molecular materials the training will be further strengthened by one secondment 6 months focused on in vivo drug delivery and imaging studies health research institute of santiago de compostela idis
effect of bioactive compounds from novel tomato on glycaemia short title bioactive compounds impact on glycaemia

combining nutrients that act synergistically and have potential to lower postprandial glycaemia is an important dietary strategy that can reduce the risk of developing noncommunicable diseases within a starchbased food matrix like bread the presence of bioactive compounds polyphenols and carotenoids can lower or delay starch digestion and therefore the postprandial glycaemic response this shows potential for development of bioactiverich starchy foods as an alternative to conventional highglycaemic foods variations in dose form and processing can result in bioactiverich functional foods with different glycaemic potencies thus further studies are needed to determine the role of polyphenols and carotenoids from tomato during digestion the aim of this project is to determine the impact of polyphenols and carotenoids from tomato naringenin and lycopene respectively on nutrient accessibility and impact on glycaemiai will investigate the interaction of naringenin and lycopene from an organically grown tomato paste enriched with tomato skin previously developed by the host group with starch and starchy foods nutrient release from a food matrix and digestion will be measured in vitro at a micro and macrostructural level using a singleenzyme digestion system and the infogest standardised static digestion model to determine the effect of naringenin and lycopene on glycaemia i will use biological samples from healthy study participants collected before and after 4week intake of tomato enriched paste from an ongoing dietary intervention study in the host group the use of tomato byproducts skin is a sustainable option to fortify foods providing added value to scraps without postharvest extraction of bioactive compounds results from this study will provide new mechanistic insight into how tomato bioactive compounds modulate starch digestion and new fundamental evidence on their influence on glycaemia
establishing of cancer mission hubs networks and synergies

cancer healthcare research and innovation face core common challenges such as fragmentation of initiatives and distancing from important stakeholders requiring coordinated solutions these challenges are recognized in horizon europes cancer mission implementation plan and in europes beating cancer plan the proposal establishing of cancer mission hubs networks and synergies echos represents a unique opportunity to coordinate ri and healthcare actions on cancer with policymaking processes creating transnational communication collaboration networks aligned with cancer mission objectives experiences shows that the setup and implementation of innovative health solutions are more likely to be successful when a broad range of stakeholders and decisionmakers from the public and private sectors are part of the process by fostering the creation of national cancer mission hubs ncmhs in member states and associated countries echos will create the conditions for organized stakeholders and individual citizens to collaborate and engage in policy dialogues the implementation of the cancer mission objectives will promote more resilient and peoplecentric healthcare and research systemsechos will produce i general models and guidelines for the creation of sustainable ncmhs ii a knowledge exchange programme to support development of ncmhs competences iii impact models and training sets to help efficiently engaging with distinct stakeholders iv a toolkit for synergies to help ncmh engaging in collaborative work with individual european initiatives v a business continuity model envisaging longterm sustainability of a eu network of ncmhs and vi a calendar of events to create awareness on ncmhs and to help closing the gap in citizens participation in cancer policy in summary echos will create conditions for ncmhs to be mission cancer advocates in msac and set the pace for the development of a transnational network of ncmhs in a second phase
piezoelectricity in 2dmaterials materials modeling and applications

piezoelectricity in twodimensional 2d materials is increasingly important because of its potential in realizing thin yet efficient and flexible piezoelectric devices in contrast to traditional threedimensional 3d piezo and ferroelectrics that are prone to size effects piezoelectricity in 2d materials may be controlled by flexoelectricity and interfaces thus providing significant piezoelectric effect in ultrathin films and crystals equally important the majority of 2d layered piezoelectrics found so far possess inplane piezoelectricity and require bending of flexible substrates to activate piezoelectric effect this severely limits their integration with modern si technology this project aims at strengthening the piezoelectric activity in 2d materials via interface and stress engineering and bond control in order to reach the maximum efficiency and other relevant figures of merit the materials list includes hafniumzirconium oxide hzo transition metal thioselenophosphates tps graphene on oxide substrates and polymer pdvf a comprehensive investigation of piezoelectricity in these 2d materials and their relevant device performance is still at an initial stage and needs european support concerning piezoelectric energy harvesting piezo2d will build a technology to provide local energy generation microgenerators from the nm to the microscale to power nano and microdevices piezo2d will do so by enhancing and deploying the combined powers of equilibrium and nonequilibrium thermodynamics and atomistic models with device physics and engineering research results will underpin future developments of nanoscale energy devices for decades to come we will also develop new characterization techniques and metrologyinspired protocols aiming at future standards and their use in the industry the multidisciplinary approach of piezo2d brings together leading teams in theoretical physics materials science chemistry and instrumentation working in synergy
socioenvironmental tradeoffs and synergies in terrestrial carbonwater coupling in a changing planet

terrestrial carbon and water cycles are strongly coupled rising atmospheric co2 and climate change have accelerated terrestrial water cycle causing reduced soil moisture and more frequent and severe droughts such environmental changes have modified vegetation functions endangering the stability of terrestrial carbon budget human activities such as deforestation and intensive water use have further influenced carbonwater coupling by exacerbating external perturbations a weakening of the terrestrial carbon sink induced by progressive water stress conditions could further destabilize the climate system with potential dramatic consequences for human societiesdespite its importance the sensitivities of terrestrial carbonwater dynamics to socioenvironmental changes remain elusive the complexity of the topic its interdisciplinarity together with knowledge and methodological gaps in observing understanding and predicting carbonwater coupling have hampered so far substantial progressestypic aims to respond to such emerging global challenge by addressing two key questions how does terrestrial carbonwater coupling respond to socioenvironmental changes how have socioenvironmental tradeoffs and synergies influenced the trajectories of terrestrial carbonwater dynamics over the last decadeshere i propose to investigate the subject with a novel approach that builds on the integration of earth observations with bigdata technologies satellite retrievals will be used in combination with advanced statistical tools to quantify spatial and temporal variations in terrestrial carbonwater coupling at the global scale the underlying socioenvironmental mechanisms will be disentangled through causal inference methods hotspot areas subject to amplification or compensatory effects between environmental and human factors will be finally identified to assist the development of landbased mitigation actions and the longterm sustainability of water resources
circuit mechanisms of behavioural variability in drosophila flight

while sensory systems report sensory input with high reliability behavioural responses are inherently variable how this variability arises and how behavioural decisions are formed is not well understood in any organism i will use the fruit fly drosophila as a model system to study how a specific behaviour is initiated depending on external stimuli and behavioural state during flight flies change direction to avoid dangers or search for food with a fast turning response called saccade this behaviour can be replicated in headfixed flying flies where saccades are measured as fast changes in wing stroke amplitude which allows for simultaneous recordings of neuronal activity however the neuronal circuits underlying the execution of saccades in the fly brain are not known previously i have discovered a descending neuron whose activity is strongly correlated with saccadic turns during headfixed flight i will use novel anatomical tools and the available em data sets to find the neurons which provide input to this descending neuron and which control saccades i will then record their activity using both 2photon calcium imaging of a genetically encoded indicator and wholecell patchclamp recordings during flight at the same time i will present a panel of multisensory stimuli while monitoring turning behaviour this will allow me to test under which stimulus conditions and internal states these neurons are active and whether their activity is more closely correlated with sensory input or behavioural output to test for the contribution of these neurons to the execution of saccades i will use genetic tools to manipulate their activity during tethered as well as free flight this comprehensive approach will allow me to study which neurons control saccadic turns and at which processing stage behavioural decisions are made and will provide general insights into how information is processed along the sensorytomotor pathway and how behaviour is initiated
insitu thermometry guidance in photomedicine

intuit project aims to pioneer the development of photonicbased spectroscopy and thermometry methods namely hyperspectral imaging hsi and optical sensing with fibre bragg gratings fbg into clinical solutions to visualize and differentiate tissue experiencing coagulative necrosis andor hyperthermia from normal healthy tissue during tumor removal involving thermal ablation this technology will improve surgical guidance minimizing the destruction of surrounding healthy tissue while achieving a complete tumor resection four work packages wps will be implemented throughout the action wp1 to study endogenous concentrations of optical biomarkers useful to differentiate the ablation margins wp2 to develop a tissue phantom to recreate the thermal gradients and optical properties of the main tissue ablation zones this phantom will be used to calibrate and validate the hsi and fbg systems wp3 to conduct observational animal studies and collect data insitu on animals undergoing oncology treatment with laser ablation and wp4 in synergy with all wps above dedicated to data processing and development of algorithms for margin detection and to guarantee appropriate data collection processing and storing the work plan will bring hsi and fbg technologies to trl 4 by month 24 of the action the next 6 months involve work at a nonacademic host to advance towards trl 5 and further plan strategies and partnerships to push the proposed technologies towards commercialization with the ultimate goal of improving veterinary and human healthcare wp1 and wp2 will be conducted at the politecnico di milano under the supervision of prof saccomandi who has expertise in thermometry the animal studies from wp3 will be supervised by dr vajdovich expert in veterinary pathology and oncology at the university of veterinary medicine budapest the data processing will be supervised by dr bocklitz from leibnizipht whos research is dedicated to photonic data lifecycle
rewilding and restoration of intertidal sediment ecosystems for carbon sequestration climate adaptation and biodiversity support

within european coastal zones intertidal areas consisting of soft sediment emerging during each low tide form complex seascapes covering more than 10 000 km2 along the 35 000 km of the tidal coastline these habitats provide multiple ecosystem services with great potential to cope with the biodiversityclimate crisis by contributing to carbon neutrality climate resilience and biodiversity support nevertheless these seascapes continue to be fragmented and threatened resulting in a decrease of their provision of services rewilding a naturebased solution is a new concept for seascapes to reverse this situation and to let again nature do the job ensuring climate resilience biodiversity support and societal benefit of the future european shorelinewithin a network of 10 demonstrators and 25 partners from 11 european states including 8 with a tidal coast plus the uk canada and the usa rewrite will bring an interdisciplinary consortium of natural and coastal environment and social sciences and humanities experts to address the current ecological and social challenges regarding intertidal seascape rewildingexpanding innovative approaches rewrite will focus on the climatebiodiversitysociety nexus to reach 4 specific objectives identify environmental social and cultural drivers and barrier parameters to rewild intertidal sediment seascapes within the context of climate change strongly engage stakeholders to achieve a stepchange in their appreciation of the natural function of these seascapes and integrate their interests within a codesign of scenario for future european shoreline estimate and upscale trajectories of intertidal seascapes from the local to the european level following rewilding passive restoring active business as usual or do nothing options establish tools and methods for successful rewilding to ensure a high ecological and societal cobenefitlowcost ratio for a climateneutral and resilient european shoreline
integrating soil biodiversity to ecosystem services testing costeffectiveness of soil biodiversity indicators and the provision of soil biodiversitybased ecosystem services to build better land management solutions that effectively implement the eu soil strategy

the aim of the eu soil strategy is that by 2050 all soils in the eu are healthy however costeffective indicators for soil biodiversity ecosystem functioning and ecosystem services are missing and so are costeffective measures for restoring soil health sob4es will contribute to the mission a soil deal for europe by 1 elucidating soil biodiversity ecosystem functioning and services for major land uses and land use intensity changes 2 testing costeffectiveness of existing indicators for soil biodiversity ecosystem functioning and services and 3 evaluating how policy incentives may enhance protection sustainable management and restoration of soil systems and soil health by focusing on nine major pedoclimatic soil typeclimate regions and land uses including soils from urban agriculture forest seminatural wetlands drylands industrial and mining environments sob4es will cover most relevant eu climatesoil typeland use conditions sob4es will further develop the mapping and assessment of ecosystem conditions maes approach for agricultural land uses envisaged sustainable agricultural practices will be compared with conventional high inputoutput practices ultimately sob4es will deliver wellvalidated and applicable indicators for soil biodiversity and ecosystem services for policy evaluation to be used in euwide soil health monitoring from the field to the landscape level sob4es will also analyse how networks of soil biodiversity relate to aboveground biodiversity and ecosystem services by advanced artificial intelligencebased machine learning approaches and scale monitoring up to being applied by remote sensing finally sob4es will support a more effective adoption of indicators by largescale european surveys such as lucas and soilbon and contribute to the development of the euso dashboard and national soil monitoring programmes
knowledge building and social innovation for a successful more effective and coproduce urban security solutions

cosecur aims to build knowledge and a suite of tools including a societal development plan sdp to foster and accelerate the adoption of social innovations and responsible innovation principles that contribute to successful more effective and coproduced security solutions for public spaces with special focus on massive events and crowded places generating trust acceptance increasing security security perception and security behavior for that cosecur will follow a methodology of 4 phases 1 literature review of evidence in security and security perception 2 security practices mapping and selection 3 descriptive analysis of 72180 case studies from 9 european countries and critical synthesis of results and 4 cowriting and validation of the sdp and tools involving the quintuple helix media through participative activities ie hybrid seminars national working groups national workshops public consultation at eu level as a result the sdp will contain a depth description of social innovation on security in europe a compendium of good practices and a roadmap of actions the suite of tools will provide additional supportive material in terms of best practices on fostering smart local communities policy recommendations on how to orientate security solutions towards rri and social innovation involving the quintuple helix media benchmarking for industry and a summary of the innovative transferable and scalable security technologies partners will continue to disseminate and communicate the project progress and outcomes and organize a final security perception conference at the conference a memorandum of understanding will be launched and opened to be signed by any cityregion willing to promote social innovation and rri in the security solutions implemented in public spaces
automated inline separation and detection of extracellular vesicles for liquid biopsy applications

the nexus project will develop an easily customizable integrated platform to enable extracellular vesicles evs separation purification and multivariate characterization from complex biofluids evs enclose a heterogeneous group of cellreleased membranous vesicles abundantly present in body fluids from which they can be extracted in a noninvasive manner their surface markers and cargo proteins nucleic acids glycans lipids represent an ideal source of diagnostic prognostic and efficacy biomarkers providing realtime information on tissue homeostasis alterations however their detection and molecular profiling is technically challenging due to their physical characteristics and huge heterogeneity the previous fet project index has validated at lab scale trl4 an integration of a selective sequential isolation and in situ enrichment of small evs sevs from plasma with the multiparameter analysis regarding vesicle size number and immunophenotype nexus aims at proceeding towards industrialisation by delivering a manufacturable fullfledged analytical instrument characterised by an appealing sample in result out design and featuring a real time in liquid measurement of scalable sample volumes nexus breakthrough technology will be achieved through integration of i innovative chemistry for reversible sevs immunocapture with unique capturereleaserecapture features ii microfluidic extraction and preconcentration of cancer sevs iii dna barcoded customizable chips for single sev capture and analysis fully automated interferometric reflectance imaging sensor providing rapid sensitive and multiplex profiling of cancer proteins displayed on sevs without the interference of soluble proteins and confounding particles other sevs and lipoproteins will be validated in the relevant industrial and clinical environment and in the context of a liquid biopsy assay for prostate cancer stratification prognosis and monitoring and prognosis trl6
harmonised approach to early feasibility studies for medical devices in the european union

eu regulations on medical devices mds invitro diagnostics and health technology assessment envisage a harmonised lifecycle approach for clinical evidence generation of mds to be effective this approach requires evidence generation plan to be developed since early stages of product development by engaging all relevant stakeholdersat present in the eu there are no standardized procedural frameworksguidelinescommon reference standards for early feasibility studies efs clinical investigations allowed by iso 141552020 conducted early in the development aiming to inform the product developmentthe ambition of the heuefs project is to develop a harmonised framework for the eu efs program as one integrated step of evidence generation cycle project objectives include 1 conducting researchanalysis on state of play ie characteristics challenges impacts of premarket programs for mds including efs 2 building a sustainable network of stakeholders at eunational level to promotesupport efs implementation 3 developing a sound widely applicable harmonised eu methodology and formulating recommendations to uptake efs 4 undertaking pilots to test the proposed framework 5 developing instruments to monitor the efs performance and 6 implementing a dedicated sustainable open access online portal dedicated to efs methodological framework best practices and networkto achieve these goals the heuefs consortium has been designed including a wide range of relevant stakeholders research organisations hta bodies patient organizations healthcare providers smes including health technology developers legal experts and a cro and 6 major private companies that are part of a preidentified industry consortium an advisory board made of competent authorities notified bodies medical and biomedical engineering professional associations networks and industry trade association will collaborate to the success of the initiative