Dragon09/odtu_chatbot huggingface dataset:
health outcomes from raised urban settings

ncds especially diabetes and cardiovascular diseases cvds are the leading causes of morbidity and mortality worldwide cvds kill more people globally than any other disease accounting for 179 million deaths per year diabetes on the other hand accounts for 2 million deaths annually these diseases have a greater impact on vulnerable populations this increased prevalence among this population is related to a range of social and environmental factors lifestyles and the impact of behavioural determinants lowincome communities such as migrants or ethnic minorities are still undertreated and unprotected by most of the healthcare systems with a lack of quality of care for ncds and a lack of preventive measures specifically adapted for themthus horus aims to tackle ncds especially diabetes and cvds in urban built environments among vulnerable populations mainly lowincome communities migrants and ethnic minorities in particular it has a twofold objective 1 first to analyse and explore in depth the causal links between the characteristics of the urban built environment and the prevalence of ncd risk behaviours in an integrated comprehensive and multiapproach manner horus will focus on existing urban interventions modifying the physicalsocial and functional characteristics of the built environment with a significant impact on the prevalence of risk behaviours and eventually ncd outcomes 2 and secondly to develop pilot interventions in three european countries spain croatia and the netherlands to promote behaviour change towards healthier lifestyles for empowering vulnerable populations and to support citizens in making optimal use of the urban environment they live in while reducing ncd risk behaviours especially those related to diabetes and cvds
improving the living and labour conditions of irregularised migrant households in europe

the project investigates the living and working conditions of irregularised migrant households in europe from an intersectional perspective it aims to reveal the spectrum of irregularity in contemporary europe and cast light on the everyday experiences of migrants with irregular unstable andor precarious legal statusiclaim develops the concept of irregularity assemblages to capture how migrants irregular condition is produced by the interplay of immigration and asylum laws policies and practice wider labour market and welfare regimes and political media and public narratives the irregular condition is shaped by migrants social position and positionality as well as by processes that occur at international european regional and local levelsthis approach will inform our theoretical understanding methodology and analytical framework and how the consortium organises its work moreover it enables us to design assess and validate detailed policy options and public interventions targeted at placespecific sectoral and intersectional criticalities and vulnerabilities experienced by a range of people in irregular situations in europeto achieve its overarching ambition we will engage at all stages of the project cycle with relevant european national local and sectoral actors in six countries finland germany italy the netherland poland and the uk through country stakeholder groups csg and a european stakeholder group eisg moreover we will organise a series of consultative and participatory initiatives to produce new knowledge inform public and political debate validate key research findings and design policy recommendations
integrative science intelligent data platform for individualized lung cancer care with immunotherapy

immunotherapy io is the new standard of care for many patients with advanced nonsmall cell lung cancer ansclc yet only around 3050 of treated patients benefit from io in the long term programmed deathligand 1 pdl1 remains the only biomarker used to predict patient outcome to io though its efficacy is limited other potential biomarkers have been identified yet not validated in prospective randomized clinical trials providing only partial evidence due to the dynamic complexity of the immune systemtumour microenvironment its interaction with the host and patient behaviour its unlikely for a single biomarker to accurately predict patient outcome artificial intelligence ai and machine learning ml frameworks that synthetize and correlate information from multiple sources are essential to develop powerful decisionmaking tools able to deal with this highly complex context and provide individualized predictions to improve patient outcomes reducing the economic burden of health care systems in nsclc the aim of the i3lung project is to develop such aibased tools to assist in improving survival and quality of life preventing undue toxicity and reducing treatment costs i3lung adopts a twopronged approach setting up a transnational platform of available data from 2000 patients in order to validate the ai models and generating a multiomics prospective data collection in 200 nsclc patients integrating diverse omic information then validate its usefulness in leading io therapeutic decisions a psychological study will help in defining the impact of aiguided decisions on patients eliciting their preference and physicians comparing ai with human intuition the final goal is the construction of a novel integrated aiassisted data storage and elaboration platform backed up by trustworthy explainable ai methodology ensuring its accessibility and ease of use by healthcare providers and patients alike
breakthrough innovation programme for a paneuropean detection and imaging ecosystem phase1b

the attract phase1b project delivers an important new angle to the already established and highly regarded attract model which created an european ecosystem for breakthrough detection imaging di technology development based on coinnovation the precursor h2020 attract phase1a and phase2 projects have already proven that in principle the development of breakthrough innovation from basic science towards market applications does not need to be a matter of chance it can lead to much faster results if managed and supported consistently through the creation of an trusted ecosystem between research academia industry and publicprivate investment communities in neither precursor projects however the attract consortium specified topics to be funded and opted for a bottom up approachin light of the societal challenges that europe faces the attract consortium now feels compelled to explore whether such approach remains valid or whether attract as an instrument can work equally well when an element of research predetermination is introduced in the attract phase1b project the predetermining factor is di for earth observation and monitoring as such technologies directly contribute to a better understanding of the dynamics of naturehuman interaction environmental changes and climate change the attract consortium will fund 30 breakthrough di concepts at 100000 each third party open call applicant consortia will have 12 months to investigate the scientific merits technical feasibility and potential gamechanging applicability potential of their concept up to trl level 35 technologies should be capable of collecting data physical chemical biological etc characteristics with high specificity and extreme sensitivity whilst offering high spatial and temporal resolution and massive parallelism they should be suitable for seamless integration into pervasive low cost and lowpower ict systems incl portable wearable iot
neoantigen identification with dendritic cell reprogramming

in cancer genetic mutations result in production of tumor neoantigens restrictively expressed in transformed cells and serve as ideal molecular targets for cancer vaccines and adoptive t cell therapies however available methods for the identification of clinically relevant neoantigens driving potent antitumor immunity are highly inefficient thus there is an urgent need for innovative solutions to identify powerful immunogenic neoantigens to unlock the full potential of immunotherapy and treat currently untreatable cancers the neoidc platform has the radical vision to use the type 1 conventional dendritic cell cdc1 reprogramming technology arising from the ercfunded project trojandc to directly identify highly immunogenic tumor neoantigens and neoantigenspecific t cell receptors tcrs for the development of powerful cancer vaccines and adoptive t cell therapies to achieve this we will firstly identify tumor peptides presented on mhc class i and ii by cdc1reprogrammed cancer cells and validate immunogenicity in vivo secondly we will expand neoantigenspecific t cells by coculture with reprogrammed cancer cells sequence tcrs and link to cognate neoantigens this will facilitate the generation of potent cancer vaccines and tumorreactive t cells for adoptive transfer experimental activities with collaborators and clinicians will be coupled with exploitation plans including partnership with asgard therapeutics ensuring commercialization by generation of novel ip broad and targeted dissemination and a new startup companyneoidc combines cdc1s antigen processing and presenting abilities with the unique mutational profile of cancer cells to enable the direct identification of immunogenic neoantigens and cognate tcrs ultimately this project will enable the development of the next generation of neoantigenbased vaccines and adoptive t cell therapies and will set the stage for a new era of safe personalized and effective cancer immunotherapies
phaseresolved thzhiggs spectroscopy on superconductors

thiggs develops higgs spectroscopy as novel tool to probe the order parameter in superconductors it will allow unprecedented insights into the structure and dynamics of the condensate and shine new light onto the physics of unconventional superconductors in particular high temperature superconductivity calls for new probes to reveal its pairing mechanism thiggs can also be applied to intriguing phenomena like light induced superconductivity superconductivity in twisttronics or under extreme conditions matching the ongoing importance of superconductivity in quantum materialsthiggs is a highfield phaseresolved nonlinear thz spectroscopy on order parameter excitations of the superconducting ground state itself the higgs oscillations probing the internal structure of the condensed cooper pairs this reveals not only the symmetry of the order parameter but also couplings of the condensate to external modes and their interplay with superconductivity
multimodal hypersprectal imaging and raman spectroscopy for intraoperative assessment of breast tumor resection margins

the spectrabreast project aims to revolutionize the assessment of tumor resection margins during breast conserving surgery bcs currently approximately 20 of breast cancer patients require a second operation due to incomplete removal of cancerous tissue this results in increased costs for the healthcare system and significant negative effects on patients wellbeing nowadays the standard margin assessment procedure is postoperative histopathological specimen analysis which takes several days to complete although intraoperative histopathological analysis on frozen tissue is possible it is less effective and cannot be implemented in all clinical centers alternative techniques have been suggested but have low diagnostic performance or take excessive time to assess the entire resected specimenspectrabreast aims to support surgeons with an intraoperative tool providing accurate and actionable feedback on the resection margin status over the whole specimen in less than 5 minutes to this end we will apply a radically new highrisk multimodal approach combining two optical techniques hyperspectral imaging hsi and fiberoptic raman spectroscopy rs with aibased dataanalysis hsi and ai will be used for fast and sensitive detection of suspicious margins which are subsequently analyzed by rs and a second ai will make the final prediction on the rs spectra the ambition is to identify tumors on and below the resection surface up to a depth of 2 mm with an unprecedented high sensitivity and specificity over 95 in realtime spectrabreast also has the potential for wider applications going beyond breast cancer to include margin assessment for other cancers roboticlaparoscopic surgery and guided biopsy finally spectrabreast will offer an objective technology reducing variability between patients and most importantly will improve patient outcomes such as reduced hospital stays complications anxiety and improved cosmetic outcomes
implementing a patientcentred and evidencebased intervention to reduce benzodiazepine and sedativehypnotic use to improve patient safety and quality of care

benzodiazepine and sedative hypnotics bshs incur significant adverse effects and costs especially in older adults addressing bsh overuse in older adults is therefore an urgent priority to improve patient safety in europe however previous attempts did not lead to largescale reduction in use the goal of besafe is to improve patient safety by addressing knowledge and practice gaps related to the reduction of bshs used for sleep difficulties in europe besafe proposes an interdisciplinary and intersectorial approach with experts in guidelines implementation dissemination case studies geriatrics and sleep besafe will emphasize patient involvement by establishing a patient partnership advisory council with patients informal carers and patient organisations which will advise on all aspects of the project besafe will conduct a survey among patients informal carers and healthcare professionals hcps to identify barriers and enablers to bsh reduction the results will inform the development of guidelines implementation recommendations and patientcentred materials to support selfmanagement the approach will be tested in a multinational cluster randomised controlled trial case studies conducted in the six countries will inform the development of countryspecific and general logic models to facilitate the scale up and spread of the besafe intervention and adapt intersectoral clinical pathways finally besafe will develop a toolkit to disseminate the new best practices to allow different european healthcare systems to implement this process in a standardised way while allowing for adaptation to account for country and context differences besafe multifaceted patientcentred approach will provide resources for patients hcps healthcare systems and policymakers throughout the diverse european healthcare landscape to reduce bsh use threatening patient safety and serve as a model to address the reduction of other harmful medications
new sustainable proteins for food feed and nonfood biobased applications

in 2050 there will be up to worldwide 10 billion inhabitants being one of the greatest environmental economic and social global challenges to produce enough quality protein sustainably reducing current pressure in its production on natural resources in this context the eu is vulnerable due to its protein gap imports 70 of proteinrich crops and 90 of soybeans there is an urgent need for new sustainable protein sources with high nutritional quality healthy and functionality properties that meet endusers needs and expectations in food feed and nonfood biobased markets it is critical to increase the consumers and industry awareness to successfully implement new proteins value chains the innoprotein project fully faces this challenge and fits into the farm to fork strategy and the european green deal priorities addressing unexploitable and sustainable environmental technological economic social protein sources to accelerate europes protein selfsufficiency the project aims to provide single cells proteins microalgae bacteria fungal and entomological alternative highquality protein to food feed and nonfood biobased applications with a circular zero waste perspective in their obtentionthe innoprotein project demonstrates a strong multiactor approach involving 15 partners including providers of technology 4 rtds 27 industrial partners 10 sme 67 and a consumeroriented partner 1 ngo 6 from 9 different european countries the duration of the project will be of 48 months with an overall estimated budget of 504384750 and a significant inkind contribution 15 by all smes of the consortia increasing the impact of the project and showing their dedication to reaching the project goals thus the requested eu contribution is 459239164
observing binaries in transition discs

star formation begins when the densest regions in molecular clouds collapse under their own weight forming so called young stellar objects ysos ie protostars surrounded by a gasdust disc known as protostellar or protoplanetary disc expected to be the birth place of planets in this newly formed protoexosolar systems the advancements during the past decade in our observational capabilities revealed that 10 of the observed protostellar discs in ysos present large 10 100 au dust and gas depleted cavities surrounding their protostars as well as a number of spectacular features such as spirals shadows and other nonaxisymmetric overdensities discs with cavities have been historically referred to as transition discs and are among the brightest and most studied ysos in close star forming regions the presence of a massive planet several jupiter masses interacting with the disc has been shown to be an effective mechanism for forming dustgas cavities and the observed structures the possibility that binary stars ie much more massive and luminous than giant planets could lie unresolved in the centre of transition disc cavities has been little explored mainly because of the argument if they were present they should be visible however both theory and observations hint that such binaries could be much harder to be detected than previously thought supporting the idea that some transition discs could be in fact circumbinary shedding light on this issue represents the heart of the observing binaries in transitiondiscs orbitd project orbitd has the ambitious goal of providing an ultimate answer to the question which transition discs are circumbinary discs surrounding undetected binaries identifying circumbinary discs in the transition disc population is key for answering a number of open questions about the process of star and planet formation widely acknowledged as major research priority by the scientific community
ancient genomics and the population history of the circumalpine region

the prehistoric pile dwellings in and around the alps constitute one of the most important archaeological archives of human prehistory dating from around 5000 to 500 bc there are over 1000 known sites in the region 111 of which are listed on unescos world heritage list the sites are mainly located under water on lake shores along rivers or in wetlands offering exceptional conditions for the preservation of organic materials like wood plant remains animal bones artefacts and even textiles because of their exceptional preservation the archaeological remains from those sites give us a unique window into the lives of prehistoric people and the development of early agrarian societies in central europe however despite the rich material evidence from the settlements we know relatively little about the people who lived there this is because there are no burials directly associated with the lake settlements which has precluded the study of ancient dna for example luckily there are other sources of ancient dna including ancient chewing gums which provide a rich of ancient human and hostassociated microbial dna as we recently demonstrated in this project we will sequence ancient dna and other biomolecules from ancient chewing gums found at lake settlements in and around the alps to shed new light on the lives of the alpine communities that settled there between 5000 and 500 bc with access to over 300 specimens from archaeological sites north and south of the alps we have the unique opportunity to study their interactions and the demographic and cultural changes that characterised the transition from the neolithic to the bronze age in central europe in addition the project promises to offer new insights into peoples health and the composition of their oral microbiome as well as their diet and subsistence strategies together the proposed research will provide us with a richer understanding of the piledwelling communities of central europe
regulatory sequence evolution during major transitions in complex multicellularity in the brown algal radiation

brown algae are a multicellular clade that display remarkable diversity in developmental and physiological complexity and in life history traits they evolved independently and more recently than animals and plants making them a uniquely powerful system to characterise the genomic changes that underlie the emergence of complex multicellularity i will specifically test the hypothesis that cisregulatory element cre evolution plays a leading role the evolution of complexity harnessing largescale multiomics datasets i will quantify lineagespecific rates of cre gains and losses and attempt to link these events to transitions in complexity i will combine signatures of constraint from a 59species wholegenome alignment with functional epigenomic data atacseq chipseq from five representative species to produce finescale maps of deeply conserved and recently acquired cres to understand the mechanisms of cre evolution i will annotate transposable elements tes and quantify variation in te diversity abundance and activity i will characterise what roles tes have had in cre dissemination i will also explore betweenspecies variation in the proportion of proximal and distal cres i will analyse highresolution hic data for four species to ask what effect distal regulation has on 3d genome organisation ie are distal cres and the genes they regulate topologically associated phaeocreevol will inform upon the rates and mechanisms of cre evolution during the emergence of complexity providing a highly pertinent comparison to animals and plants this will increase our knowledge of regulatory evolution in general while shedding light onto the fundamental biology of a largely unstudied eukaryotic group brown algae play critical ecological roles and have significant potential to mitigate climate change enhance global food security and deliver novel industrial solutions providing key motivations to better understand their genetics and evolution