Dragon09/odtu_chatbot huggingface dataset:
ai organoid image analysis

organoids are microscopically small patientderived 3d organs that can be cultivated in the laboratory over months mimicking human organs and their functions in vitro these miniorgans have a human genetic background maintain disease traits in vitro and are currently available for almost every human organ due to these advantages organoid research and its commercial applications are rapidly evolving and increasingly used given the high variability of these complex 3d structures classical cell culturebased image quantification tools techniques do not accurately capture organoids in microscope images this has resulted in much image quantification at our laboratory like in many others being performed using manual timeconsuming tools with a high researcher variability in sum there is a global challenge to in a standardized manner quantify organoid experiments we propose the first software as a service saas toolbox explicitly tailored to organoid imaging building upon powerful aibased algorithms for cuttingedge image quantification and independent of the underlying microscope and culture system hardware the saas seamlessly fits in the analysis workflow by offering a userfriendly approach to upload brightfield and immunofluorescence microscope images and videos of organoid cultures which at the core of our product are automatically quantified by aimodels generating a range of organoid metrics overall the provided automation drastically reduces analysis time promotes accurate phenotypical organoid analyses and ensures standardization of results between different researchers culture conditions and imaging hardware integrated in an easytouse web app the saas tool is of great interest and essential for researchers working in the emerging field of organoids as shown by the high utilization in our laboratory and the high interest from external partner institutions
the iaea and the two koreas history of the rok and the drpk in their challenges and contribution to the international nuclear safeguards and verification regime

international verification through the international atomic energy agency iaea safeguards forms the cornerstone of global nuclear nonproliferation efforts to prevent the misuse of nuclear material and technology for military purposes this research examines several critical junctures in the historical development of the relationship between the iaea and the two koreas south korea rok and north korea dprk to address how this international organization has evolved in its handling of nuclear proliferators historical paths of the iaea with the two koreas the north which succeeded in developing its own bombs vs the south which abandoned its weapons program have been more complicated and less onesided than what is commonly believed south korea became an iaea member state in 1957 and ratified the npt in 1975 but it maintained a clandestine nuclear weapons program throughout the 1970s furthermore although south koreas military nuclear pursuits were halted when its president was assassinated in 1979 suspicions about its nuclear ambitions were revived when the rok government disclosed its past nuclear activities as it signed the additional protocol with the iaea in 2004 it revealed that rok scientists separated a small amount of plutonium from irradiated uranium in 1982 and conducted some laboratoryscale experiments in 2000 to enrich uranium up to a higher level than what was allowed by the iaea the case of the dprk with the iaea was more dramatic as widely known with its withdrawal from iaea membership in 1994 and its expulsion of iaea inspectors thus based on extensive research in the rok us and iaea archives analysis of opensource data and interviews with key stakeholders this project intends to shed new light on the understudied history of the two koreas challenges and contribution to the iaea and further examine any lessons that the iaea learned through its turbulent relationship with one successful and one failed proliferator
precision nutrition and postprandial immune responses

a grand challenge for sustainable development in europe is to improve public health through reducing incidence of noncommunicable diseases premature mortality and health costs an unhealthy diet is one of the most important risk factors for the global burden of diseases therefore changing the dietary habits in the population is urgently needed precision nutrition is an important area for eus research and innovation policy food2030 and has emerged as a paradigm with promising results that could help to improve health in the postgenome era to allow development of more effective preventive strategies via precision nutrition the determinants driving the interpersonal differences in response to specific foods and meals need to be better understood this implies also the underlying mechanisms causing differential responses we eat meals several times per day and are constantly in the postprandial phase postprandial changes in circulating metabolites play a major role on human health and the immune response this leads to the question if one can predict the type of meal which will be most beneficial to improve an individuals metabolic health once such knowledge emerges tailored stratified dietary advice can be developed and evaluated the focus of nutriome is to train 10 research doctoral candidates rdcs in datadriven precision nutrition using two complementary training strategies to learn how to handle and combine multiomics data to evaluate the response to foods and diets we will provide multidisciplinary training so that the rdcs i are able to utilize share and disseminate public available multiomics data ii know the regulations and routine for collaborative data sharing in a fair manner and iii are experts in analyzing integrating and interpreting increasingly complex data this will provide a new competence profile to resolve a bottleneck for development of personalised preventive solutions for improved health in europe
logic and automata over sequences with data

formal language theory is indisputably one of the most successful theories in theoretical computer science with many applications in such fields as formal verification programming languages and databases to name a few despite this the standard restriction to finite alphabets has been a limiting factor in the applicability of the theory in various important application domains wherein sequences with data ie ranging over an infinite domain like the set of integers and the set of strings naturally arise this has motivated an extensive study of automata over infinite alphabets in the last three decades which aims to develop algorithms for analyzing data languages it was however quickly realized that permitting anything but the simplest data reasoning results in undecidability for the most fundamental models in the theory given the growing practical needs for tools for reasoning about sequences with data it is crucial that we break through this undecidability barrier the aim of the project is to overcome the current undecidability barrier in extending automata theory over infinite alphabets with complex data reasoning the first concrete objective is thus to identify new decidable logicautomata models for data languages that permit complex data reasoning over various data domains eg integer linear arithmetic realclosed fields string constraints etc and to develop efficient algorithms for analyzing them in addition to making fundamental theoretical contributions in automata theoryover infinite alphabets i also aim to address the current practical needs for tools for reasoning about sequencesthus the second objective of the project is to transfer new algorithmic insights to the following important application domains1 querying graph databases 2 verification of listmanipulating programs and 3 interpretable machine learning for sequences
transformation of energy intensive process industries through integration of energy process and feedstock flexibility

trineflex is an integrated eiitransformation toolkit following the x as a service model for the endusers eiis trineflex will function as an endtoend service managing the plants digital lifecycle and the process of transition to flexible and sustainable operation this process will be enabled by advanced and green data acquisition big data infrastructures process analysis model development and finally digital twins with integrated multiagent decision support systems trineflex will be implemented at each of five demonstration sites with unique challenges from 4 sectors glass copper aluminium and water industries the implementation will be supported through the integration of transformative technologies from the energy efficiency clean energy sustainable fuels and feedstocks and ccus sectors that synergise with the powerful digital solutions to demonstrate flexibility measures towards energy neutrality additionally trineflex is designed for rapid replicability in these sectors and high transferability in other p4planet sectors centred on energy flexibility on the short term and industrial symbiosis on the long termtrineflex will mobilise local stakeholders and communities into new ways of interacting with the energy and process industries capacity building open science and introducing new forms of sustainable economic activity service and communitybased demandresponse will be employed to leverage local energy resources coupled with emphasis on sustainable fuels and feedstocks accelerating the adoption of industrialurban symbiosis8 large companies 7 smes will work with rtos and supporting entities to achieve over 8 reduction of energy costs 18 peak reduction flexibility cost below 12 kwh over 8 energy demand reduction that are projected to yield over 330gwh of energy savings 45m in energy costs and co2 tax over 110kt of co2 averted and over 800 jobs created by 2030 trineflex private investment is around 4m
thermal energy storage solutions to optimally manage buildings and unlock their grid balancing and flexibility potential

thumbs up aims to develop and demonstrate thermal energy storage tes at daily based on environmental friendly pcm and weekly level based on tcm sorption technology solutions to be easily integrated in eu buildings both connected and notconnected to dhn to increase their energy efficiency as well as to exploit powertoheat pth approaches also to make eu buildings as grid flexibility actors thumbs up wants to overcome all the limits of stateoftheart buildingintegrated pcm and tcm tes technologies increasing tes energy density and reducing capex thumbs up innovates at different levels from modelling to materials and enhance heat exchanger solutions targeting demonstration at trl 7 highperformance tes solutions part of an eu sustainable economy is a factor at the core of thumbs up the project develops truly i biobased pcms from raw materials currently wasted in the eu food industry turning them into valuable tes materials and ii tcms relying exclusively on nonhazardous materials and on water as working fluid thumbs up tes will be demonstrated in 3 demosites a singlefamily building in spain and 2 multifamily buildings in swedenspain in different eu climates and energy market contexts also to assess thumbs up replication potential in two replication sites ita nl via its demonstration and replication campaign thumbs up promotes tes role as key enabling technology to optimize thermal comfort and energy efficiency in buildings as well as to promote pth as facilitator of res grid integration in a sector coupling approach to be studied via innovative modelling tools thumbs up gives specific attention to how to fully integrate tes solutions into buildings and wider smart energy networks by combining the technology advancements with testailored digital innovations thumbs up widens the capability to control monitor and forecasts how to operate buildingintegrated tes systems to provide services toward both the hc and power sector
a circular economy aproach for the valorization of orange peel waste to establish food safety

food safety and food waste management remain two major challenges in europe with enormous effects on the economy the environment and public health each year 23 million cases of foodborne illness and 5000 deaths are reported in europe at the same time one third of food produced for human consumption is wasted because it is considered unfit for consumption which amounts to approximately 13 billion tons each year therefore the development of innovative measures to reduce food waste presents a viable alternative in a situation where new solutions are desperately required in this sense the development of circular economies that revalorize byproducts and residues of food industries as products that can be reused is a promising research avenuewastetosafety will confront this challenge by developing the scientific basis to implement a circular economy that uses waste from the citrus industry to extend the shelf life of fresh produce from the mediterranean area namely it will optimize two green methods microwave ultrasound for the extraction of essential oils eo from orange peel the eo will be used as the basis for two food preservation technologies a washing solution and an active packaging the project will also evaluate their potential impact on the food chain through a quantitative microbiological risk assessment qmra a life cycle analysis lca combined with a material flow analysis wastetosafety will thus provide tangible advances to the field of food science developing a noticeable solution for the revalorization and utilization of citrus waste it will also open new research avenues related to the upscaling of these technologies to an industrial level
controlling oxygen selectivity at the atomic scale

developing new materials with optimized catalytic properties is a crucial challenge towards sustainable energy production in order to achieve this longstanding goal fundamental understanding of the processes taking place at the electrodeelectrolyte interface is vital progress here requires a comprehensive atomicscale picture of the fundamental chemical and catalytic properties of surfaces in connection to their macroscopic catalytic performance this knowledge remains hindered due to the complexity of real catalytic systems and the lack of experimental techniques that can provide information of the catalytic process from singlemolecule interaction to operando conditionsthe project cosas focuses on the electrochemical water oxidation to hydrogen peroxide and seawater electrolysis it proposes an atomistic study of the electrodeelectrolyte surface to unveil the key parameters for selective activation of alternative reaction paths for water oxidation the experimental approach of the project represents a novel quasiin situ electrochemical characterization near ambient pressure xray photoemission spectroscopy combined with atomicscale access to the electronic structure scanning tunnelling microscopy and spectroscopy on the very same sample the project will study thin films of transition metal oxides as model systems for exploring structurefunction relationships while presenting catalytic relevance for oxygen related reactions the unique methodology of the project promises novel atomistic insight in the mechanism behind complex reactions with multiple intermediates unveiling key parameters that can guide the design of active and selective electrocatalysts for costeffective water electrolysis
flat bands for quantum metrology

the ultimate limit on the accuracy of any measurement is set by quantum mechanics this also means that quantum effects can be used in metrology and sensing to go well beyond any classical approach for classical systems statistical error is proportional to 1sqrtn with n the number of measured particles measurements in quantum systems can overcome this limit and reach the heisenberg limit proportional to 1n however quantum standards and sensors are challenging to put in practice and their working conditions are nowadays intrinsically incompatible eg magnetic field and superconductivity therefore limiting their reach in terms of users and their development as accurate and enhanced quantum technologies the vision we propose in flats is to use twisted bilayer graphene as a multiphenomena platform to develop present electrical quantum metrology standards working under compatible conditions and to develop the new generation of metrological sensor going beyond the international system of units si their common platform will allow their integration as a single multiuse onchip quantum labto achieve this we will first create a european twistronics plateform for an unprecedented control of the relative angular alignment between graphenebn layers we will develop novel and original quantum electrical standards with twisted heterostructures our onchip metrological quantum lab also enables the implementation of metrological sensors beyond the si this will be the first step towards quantumenhanced measurements for metrological applications
development and validation of a new magnetocaloric highperformance hydrogen liquefier prototype

hylical will contribute to reaching an energy demand of 8 kwhkg and a liquefaction cost of 15 kg as targeted in the call by validating an innovative and energyefficient liquefier prototype for the cryogenic region 120 k based on magnetic refrigeration the implementation of the magnetocaloric hydrogen liquefaction mchl technology developed in hylical offers the following perspectives i increased energy efficiency of 20 for small liquefaction volumes of 5 tonnes per day tpd and up to 50 for 5 tpd ii reduced capital expenditures capex and operating expenses opex by at least 20 in addition to the targeted energy savings iii decentralized local production of liquid hydrogen lh2 thus reducing the need for distribution and transport across long distances iv coupling of the mchl technology to hydrogen production from renewables green hydrogen for offgrid configurations v integration into conventional liquefaction plants to increase their overall energy efficiency vi application of the process for the liquefaction of hydrogen and for boiloff management of lh2 tanksthe mchl technology will enable the decentralized production of green lh2 in competition with lh2 from fossil sources and will furthermore reduce the need to transport lh2 over large distances if there is a local green energy source available eg biobased or electricity from renewables we will drive the technology relevance level for mchl technology from initially trl 3 to trl 5 at project end this will be achieved by significantly increasing the liquefaction capacity of the demonstrator from the current soa 1 kgday to close to 100 kgday we will demonstrate that there are no intrinsic limitations that prevent the mchl technology from being scaled up to suit flowrates above 100 tpd as highlighted in the call thus satisfying the need for largescale production capacities needed in the heavyduty mobility sector and elsewhere
prime editing to repair inherited metabolic errors in vivo gene correction for human genetic disease

treatment options are insufficient for the majority of genetic metabolic diseases methylmalonic acidemia mma is one such severe metabolic disease with current therapeutic strategies patients still develop metabolic decompensations brain damage kidney failure and have a lifelong risk to acutely become blind repair of the genetic cause of disease would revolutionize outcomes for these patients especially with increasing detection in neonatal screening programs this makes it possible to correct the cause of disease prior to the onset of irreversible damage however efficiency safety versatility and delivery of precise gene editing is not yet sufficient for in vivo genecorrection therapiesthe aim of this proposal is to develop an in vivo geneediting therapy program for patients with metabolic diseases targeting the liver where most metabolic genes are highly expressed as a proofofprinciple i will repair genetic causes of mma validate this in personalized cells and mouse models and lay the groundwork for human trialsto this end i will1 generate a clinically applicable geneediting technique i recently demonstrated that the novel geneediting technique prime editing could accurately correct different mutations in patientderived organoids using an innovative reporter and patientderived organoids i will develop prime editing into an efficient and safe strategy that can correct 90 of patient mutations2 create a system for in vivo delivery of the primeediting machinery with lipid nanoparticles to target the liver using patientderived liver organoids and an existing mma mouse model 3 develop a roadmap to tailor genecorrection therapies to individual patients using the reporter with the patient mutation and mutational context patientderived organoids and a mutationspecific animal model for a common mma mutationthis foundational work will lay the basis for broad clinical application of precise geneediting therapies
human traffickers the social circuits of human trafficking and transnational organised crime

during the past two decades millions of euros have been spent by national governments and international organisations on combatting human trafficking and on offering assistance to victims of trafficking however we know surprisingly little about the people who facilitate manage and orchestrate human trafficking the traffickers but who are the human traffickers if we look beyond the stereotypes the trafficker project will answer this question and fill this knowledgelacuna by ethnographically investigating the business operations and social relationships of human traffickers via the analytical concept of social circuitsthe project is based on ethnographic fieldwork in two sites in respectively one country of origin and one destination country of the traffickers a the city of galati in eastern romania and b in prisons in lisbon portugal among inmates that are incarcerated for human trafficking the trafficker project builds on my extensive research and fieldwork experience within the fields of transnational crime thirdparty facilitationpimping and sex work this background is essential to the project since it provides access to the necessary local networks as well as providing the needed methodological knowledge and ethical awarenessthe project illuminates1 how human trafficking is carried out by traffickers on the ground and thus how national criminal networks make their illegal business transnational2 the ways in which the kinships relations and social relationships of human traffickers hinder or enable their transnational criminal livelihood3 the lives of human traffickers both during and after imprisonment and their navigation of legal and illegal work domainsthis knowledge will not only be beneficial for the academic research community on transnational organised crime but also for stakeholders such as ngos policy makers international organisations governments and law enforcement as well as for the wider public