Dragon09/odtu_chatbot huggingface dataset:
highperformance computational photochemistry and spectroscopy

the future of modern sustainable technologies lies in the exploitation of solar energy and in harnessing the suns practically infinite energy for fundamental as well as targetoriented research in this direction computer simulations of the ongoing photochemical processes and electronic spectroscopy of the underlying molecular materials are indispensable while for smaller molecules computational photochemistry can nowadays provide highly accurate results and reliable predictions the limit in applicable molecular system size is quickly reached and the obtained results often come with an unpredictable error requiring a posteriori validation indeed we are lacking efficient and sufficiently accurate and reliable excitedstate ab initio methods reaching out for organic molecular systems with more than 500 secondrow atoms in hipercops we aim at closing this gap by deriving highly efficient and genuinely parallel ab initio methods for the calculation of excited electronic electrondetached and electronattached states for execution on modern highperformance computer architectures whose full potential is impossible to leverage by existing standard quantum chemical program packages to address this problem we choose the algebraicdiagrammatic construction adc family of methods since these schemes offer clear advantages for instance numerical stability easy to use predictable accuracy we will exploit novel genuinely parallel concepts and solution strategies for adc schemes to enable them for hpc architectures our developed methods and resulting easytouse software will thus push the boundaries of accurate and predictable computational photochemistry to unprecedented molecular system sizes enabling and promoting research in for example the areas of functional optoelectronic devices and photovoltaics molecular solar thermal energy conversion solardriven nanomachines towards efficient molecular harnessing of sun light
engineering b cells to fight cancer

b cells have an important role in the immune response against cancer tumor specific b cells in tertiary lymphoid structures and antitumor antibodies in the plasma are associated with a favorable prognosis and with an improved response to checkpoint inhibition in different sarcomas and carcinomas antigen specific b cells home to tumors and prolong survival in mice while b cell based vaccines allow durable antitumor activity in cervical cancer patients we have recently demonstrated both ex vivo and in vivo b cell engineering for the expression of antihiv antibodies here we propose a novel cancer immunotherapy approach based on engineered b cells in particular we use crisprcas9 and aav to target the integration of antitumor antibody genes into the igh locus in diverse tumor models we plan to demonstrate localized b cell activation upon antigen engagement the b cells will exert multiple antitumor effects secreted antibodies will induce adcc cdc and adcp in addition a polyclonal t cell response with epitope spreading will be facilitated by engineered b cells acting as apcs as well as by antibodies forming immune complexes to be taken up by dendritic cells and macrophages for crosspresentation the b cell will be coengineered to locally secrete additional immune effectors upon activation these include stimulatory cytokines bites checkpoint inhibitors cd4027 agonists and cell penetrating nanobodies localized secretion is predicted to increase efficacy while reducing systemic toxicities when targeting selfantigens b cells will be engineered to coexpress a car relaying cd40 or tlr signals for t cell independent b cell activation and allowing allogeneic therapy we will further demonstrate in vivo b cell engineering for increased scalability and ensure safety using a suicide cassette for inducible b cell elimination b cell engineering is thus a flexible and robust platform technology that may revolutionize cancer immunotherapy
cooperative robotics powered by ai and data for flexible production cells

the highmix lowvolume hmlv market scenario requires constant changes in jobs materials and machines this implies the need to build highly flexible and intelligent manufacturing environments that allow a fast adaption of processes and systems to changing conditions assuring high product quality with lower production costs and energy consumption this urges manufacturing industries to redefine their production processes for competitiveness and sustainability most of the manufactured components have joints so welding technologies are identified at european level as key enabling technologies for the development of innovative and sustainable manufacturing processes among welding technologies arcbased accounted for 36 of the total in 2020 highlighting its relevance for major european industries traditionally robots have been used in mass production industries performing repetitive tasks at acceptable cost and quality levels sacrificing flexibility for productivity the cooperation of multiple robots powered with ia and data technologies offers new operational capabilities in terms of manoeuvrability and manipulability in several industrial processes corob proposes the development of a smart cooperative multirobotic system for flexible and reconfigurable manufacturing to cover hmlv industrial production needs in the current technological context of industry 50 the system will be humancentered and will integrate advancements in robotics inspection monitoring control and ai developed by consortium partners and 15 external third parties through an open call the flexible solution will be validated in 2 semiindustrial pilots for automotive sector multirobot cooperative arc welding and toolmaking industry multirobot cooperative waam wire arc additive manufacturing for repairing it will contribute to resilience resource saving circular economy cost savings and digital supply chain fostering european industrial competitiveness
the role of the gut microbiome in host responses to environmental variation within and across generations and species

the gut microbiome is strongly linked to health and sickness a current key challenge is to understand how the microbiome helps the host adapt to environmental variation yet most research originates from few laboratory animal models and thus misses large parts of environmental physiological and lifehistory variation while data from wild populations and species is needed thus our overarching aim is to unravel how the microbiome mediates hosts responses to environmental variation covering molecular to evolutionary scale using wild birds as a study system we focus on how gut microbiome helps hosts to cope with temperature variation given the pervasiveness of temperature as a challenge across taxa and climatecrisis driven thermal challenges the objectiveso1 to study the role of the microbiome in mediating host adaptive reversible thermal plasticity in adulthoodo2 to assess the role of the microbiome in mediating host adaptive developmental and transgenerational thermal plasticity and explore the underlying epigenetic changes o3 to quantify the contribution of host genetic variation and the microbiome on host thermal physiology o4 to explore the macroevolutionary patterns of microbiome and host thermal physiology o5 to examine the underlying molecular mediators of hostmicrobiome interactionsto understand the causal role of microbiome we apply stateoftheart methods incl microbiome transplants within and across populations o1 and generations o2 and identify the molecular mediators incl bacterial vesicles o5 many tools adapted from the biomedical field to ecoevo research we further use quantitative genetics reaction norms selection lines o3 and multivariate phylogenetic models o4 rarely used in hostmicrobiome field opening new lines of research we produce groundbreaking findings on the microbiomemediated mechanisms of phenotypic variation which helps to predict how organisms respond to anthropog
commercialising a smart cardiac implant platform for the treatment of chronic cardiovascular disease

every year chronic cardiac disease causes 39 million deaths in europe thats a death every 8 seconds overall chronic cardiac disease is estimated to cost the eu 210 billionyr in direct healthcare costs all chronic cardiac disease patients are at high risk of stroke atrial fibrillation or heart failurethe aurigen platform is single minded in its focus on the leading causes of death in the developed world cardiovascular diseases allowing more complex patients to be treated more effectively and at a lower cost per patientaurigens platform of 4 devices is built around our custom cardiac implant to which we can add synergistic modules such as cardiac monitoring ablation or both modules creating devices which are much more than the sum of their parts this our key usp allowing aurigen to efficiently effectively manage the most expensive suboptimally treated patients in a single safe fast minimally invasive procedure
air traffic control trajectory based operations

the air traffic control trajectory based operations atctbo project proposes to validate tbo sesar solutions for flights in the tactical execution phase for enroute and tma operations thus contributing to the finalisation of the sesar phase c developed in sesar 2020 and the realisation of the digital european sky vision in sesar phase d the results are expected to contribute to capacity operational efficiency safety environment and cost efficiencythe sesar solutions with the trleocvm levels at the start and end of the project aresolution 4 improved automation in sector planning and separation management via enhanced trajectory predictions and controller tools including the completion of solution 53a from sesar 2020 to v3 initial trl4v2
first time ultrasensitive and simultaneous quantification of proteins interactions and posttranslational modifications in single cells to enable exponential growth in proteomics and interactomics

in a human cell there are about 20k protein coding genes genome that originate 100k proteins proteome proteins are involved in complex networks of proteinprotein interactions ppis influenced by posttranslational modifications ptms the interactome of living cells 800000 entities the genome is mostly static throughout cell lifetime and can be sequenced today in 1h the proteome and interactome are changing with eg environment and health and not yet fully known todays methods for proteomics and interactomics are tedious and lack sensitivity quantitativity and parallelismpicongs combines ultrahigh sensitivity 10 fm with high parallelism measuring proteins ppis and ptms simultaneously 50 targets this will disrupt the global proteomics market 29 b worth 16 cagr this will fertilise groundbreaking academic research and accelerate developments in eg pharma drug discovery biotech biomarkersdiagnosis and agrotech crop sciences industries
museum artwork sustainable technology for energy efficiency and conservation enhancement

the masterpiece project aims to create a transformative change in the conservation of wooden panel paintings wpps from the middle ages and renaissance integral to our shared cultural heritage these artworks are susceptible to environmental conditions like humidity and temperature fluctuations challenging traditional conservation methods the project proposes an innovative approach by integrating energyefficient climate control and advanced digital modeling to optimize both preservation and sustainabilitytraditional climate control systems in museums contribute to an unsustainable energy footprint masterpiece addresses this by using adaptive climate control strategies that take into account the unique needs of each artwork through collaboration with the getty conservation institute gci a leader in art conservation the project will develop digital twinsdigital replicas that simulate the artworks hygromechanical behavior in realtimerather than focusing solely on vulnerability masterpiece introduces the concept of resilience through fragilityresilience curves these curves enable a nuanced understanding of how artworks respond to environmental stressors informing targeted and effective conservation strategies that harmonize with energy efficiency goalsthe project will unfold in two key phases the first phase at the gci will focus on creating the digital twins and fragilityresilience curves the second phase will conduct mechanical characterization tests on historical paintings to validate and refine these models ensuring their broader applicability and impactmasterpiece aims to redefine standards in art conservation by offering an interdisciplinary solution that harmonizes the need for energyefficient practices with effective longterm preservation by integrating advanced technologies with conservation science masterpiece aspires to make a lasting positive impact on global art preservation strategies
unlocking efficient biobased fertilisers for soil sustainability from underutilised side streams

landfeed will focus on creating value from underutilised waste from the agrofood industry forestry urban and natural waste implementing circular and local solutions that allow waste to be valorised by placing it in a circular framework and producing innovative biofertilisers to improve europes selfsufficiency in addition to optimising and implementing innovative nutrient recovery technologies work will be carried out on a new generation of coatings for these biobased fertilisers capable of improving their efficiency through controlled nutrient release mechanisms in this way landfeed will contribute to a better management of the fertiliser provided we will contribute to lower greenhouse gas emissions and a reduced impact on the environments water resources landfeed will ensure that the solutions and results of the project are locally driven through the different use cases the use cases will consider all links in the value chain that will participate as lighthouses serving as demonstrators and disseminators of the technologies results and applications developed during the projectthese use cases will also contribute to the objectives of the soil strategy by enabling the restoration of soil health through the enhancement of its specific and functional biodiversity at the global level the business model will be defined in its entirety with the aim of maximising the replicability of these use cases and facilitating their implementation in other european areas and regions
transforming industrial part replacement and after sales through visual search and synthetic images

industrial manufacturers and their customers need to identify and retrieve spare parts quickly and efficiently our visual search engine allows any spare part to be found in manufacturers catalogues by simply taking or sharing an image of it it has proven to be by far the most accurate tool compared with several large competitors most importantly we can overcome the key hurdle to visual searches for industrial applications the availability of images for ai network training large manufacturers struggle to undertake the timeconsuming and expensive effort of producing these images for all spare parts and machines through manual photography we are the only company in the market who can produce synthetic images from cad data which outperform real data in training and search accuracy moreover we can onboard customers in a matter of minutes at nyris we give search the power of sight
european network for neurodevelopmental rasopathies

cardiofaciocutaneous syndrome costello syndrome and syngap1related encephalopathy are rare neurodevelopmental rasopathies manifesting with severe intellectual disability seizures and autism spectrum disorder these symptoms are underdiagnosed and lack approved therapeutic options euras aims to develop new effective therapies and operative disease management for rasopathies with strong support of patient organizations from 13 countries a new patient reportbased registry for stratification of patient cohorts and evaluation of treatments will be implemented to clarify the pathophysiology of rasopathies and to identify cellularmolecular disease signatures as biomarkers for drug screening and for therapy validation euras will generate new and employ existing disease models phenotypical screenings of drug libraries assisted by automated highresolution highcontent pipelines will be conducted on differentiated electrically active patient ipscderived neurons preclinical proofofconcept trials with repurposed drugs antisense oligonucleotides and motorcognitive training will be performed to achieve reversal of seizures and autistic behavioural traits in animal models to provide patients with less invasive treatments new technologies for efficient drug delivery of treatments to the brain will be developed and validated finally euras establishes europewide patient association to improve awareness and exchange between affected families and to foster their access to knowledge and therapies with all these measures euras delivers new effective therapies and set the frame for early and accurate diagnosis of neurological symptoms in rasopathies which are not available at present moreover some results of euras will be widely transferable fostering development of therapies even for unrelated diseases thus euras will sustainably improve the lives of affected people and strengthen expertise of health systems in europe and worldwide
change hubs for ecosystemic social solutions

it is now widely accepted in europe that we need new approaches if we are to tackle the systemic and urgent societal challenges we face traditional technological or business innovation alone is not sufficient social must be part of the bigger innovation picture with significant support from the european commission social innovation is currently well embedded in several policy agendas and funding streams there are hundreds of social innovation centres university research teams accelerators and educational courses labs accelerators and incubators of all kinds as well as a great number of toolkits presenting the various innovative approaches and methodologies that can be applied by students and established practitioners alike despite this success the full potential of social innovation remains untapped different project reports and academic papers published in the past five years have pointed to several interconnected barriers hindering social innovation initiatives drawing specif despite this success the full potential of social innovation remains untapped different project reports and academic papers published in the past five years have pointed to several interconnected barriers hindering social innovation initiatives drawing specifically on the outcomes of three projects that members of this consortium have participated in sidrive sic and labs for social innovation we highlight the following challenges that merit critical attention1 social innovation lacks access to finance scaling models and qualified personnel and is not applied enough2 social innovators act in silos and are not integrated into the wider innovation ecosystems 3 social innovation toolkits are plentiful but there is a lack of records about the tools effectiveness and pertinence the chess project tackles the above challenges headon by designing implementing and testing a social innovation action manual in four locally specific contexts
correction of syngap haplodeficiencyrelated defects in ampa receptor dynamic nanoscale organization

pathogenic syngap gene mutations generally lead to haploinsufficiency and account for up to 1 of intellectual disability cases syngap is one of the most abundant postsynaptic proteins that maintains a low basal activity in excitatory synapses it acts through ampa type glutamate receptors ampar that mediate most fast excitatory neurotransmission in the brain in syngap haplodeficiency ampar trafficking and surface expression are dysregulated and synaptic plasticity is impaired in our project we aim to 1 study how syngap regulates the surface nanoorganization of ampar subunits 2 validate a novel strategy to stabilize syngap in the postsynaptic region using innovative molecular tools 3 exploit our strategy as well as pharmacological approaches to restore normal synaptic transmission and plasticity in syngap neuronswe will use recently developed and validated antibody fragments against each ampar subunit with 4color dstormupaint microscopy to uncover their specific nanoscale coorganization furthermore we will test novel synthetic nanobodies specific to calcium permeable receptors to provide the first direct microscopy evidence on their synaptic distribution in relation to syngap haplodeficiency we will test a newly engineered family of proteins created in our group that aims to stabilize the complex of psd95 and syngap to counter the loss of half the syngap protein in haplodeficient neurons at different time windows as syngap affects neuronal maturation and synaptic development we will also aim to reverse the upregulation of calcium permeable ampars observed in syngap haploinsufficiency by selectively blocking them with naspm together our expected results will provide unprecedented insight to the regulation of excitatory synapses as well as novel strategies to experimentally correct syngap haplodeficiency
raising the biobased industrial feedstock capacity of marginal lands

at the present 6070 of all soils in europe are in unhealthy conditions mainly because of poor land management practices pollution of soils intensive agriculture and the constant effects of climate change this situation is further aggravated given that 25 of land is at a high or very high risk of suffering desertification in most parts of europemarginup proposes a strategy to secure use and return profitability on marginal lands its main objective is to introduce climateresilient and biodiversityfriendly nonfood crops for sustainable industrial feedstock in marginalised and lowproductivity lands the project will focus on producing biomass to be used as raw material for the production of bioproducts and biofuels which in turn will create a sustainable and circular value chain increasing the farming system resilience in rural areas to further enhance the biodiversity beneficial impact marginup is focusing on understanding which marginal lands are suitable for low iluc biomass productionthe knowledge gathered in this project will be put into practice in 5 different use cases located in 5 different regions across europe mediterranean lands spainmine lands greeceboreal lands swedenwetlands germanycentral europe hungarymoreover international cooperation has been considered and examination and identification of marginal lands will extend to noneuropean countries such as argentina and south africato ensure the success of the project marginup will have a replication network to address the needs and requirements of relevant stakeholders including policymakers land managers farmers the biobased industry environmental authorities the academia and the civil societymarginup is directly contributing to european policies such as the european green deal the circular economy action plan and the bioeconomy and biodiversity strategies