Dragon09/odtu_chatbot huggingface dataset:
agents of logistics and infrastructure in eighteenth century alpine transit traffic

alpinnkonnect centres on operating transeuropean commercial traffic as engine and manifestation of eighteenthcentury prosperity the project focuses on the interplay of agents material prerequisites and natural impacts along main alpine transit routes applying an approach of sociomaterialnatural interconnectedness it advances the hypothesis that transportation required a broad participation to cope with the enormous efforts and provided an important source of income hence seen through the lens of transit traffic new light will be shed on local social fabrics among the key figures alpine innkeepers acted as connecting agents and inns operated as multipurpose hubs of transit traffic considering the fundamental importance of transit traffic the fragmented and dated state of research is striking alpinnkonnect breaks new ground by adopting approaches of new materialism and a relational concept of logistics and infrastructure focusing on innkeepers hauliers carters raftsmen muleteers and rod cooperatives as protagonists and integrating households marriage kinship property and gender as factors in this economic key sector the main goal is to arrive at a comprehensive and empirically verified understanding of the preconditions processes implications and dynamics of transit traffic and its changes alpinkonnect argues that transit routes remained vital during the eighteenth century not despite but complementary to the economic rise of northwestern europe and its maritime traffic the principal research question is how did the interplay between the different agents the built materiality and alpine nature work how did the flows of goods which accounted for a significant share of the early modern european economy cross the continent on alpine routes how was their transit maintained facilitated or hindered alpinnkonnect proposes to reconceptualise social history by symmetrically linking historical anthropology with new materialisms
evolutionary solutions for realising a holistic safe system approach for all road users

the successful implementation of eus 20212030 road safety policy is a milestone towards the target of zero fatalities in road transport by 2050 and requires a clear understanding of criteria that influence safety performance development of solutions that promote safety for all road users the modernisation of existing infrastructure monitoring approaches and the adoption of methodologies that take into account complex user behaviours evoroads aims to accelerate the attainment of the vision zero eu goal through a holistic framework of innovative models tools and services that enable datadriven evolution of safety assessment frameworks facilitate dynamic monitoring of cyberphysical infrastructures and promote the proactive warning for safety risks in complex environments at the operational level evoroads defines safety criteria and kpis quantification methodologies covering the entire spectrum of the safe system approach and develops a connectivity platform where transport infrastructure assets are digitalised and safety assessment services are functioning in a harmonious way advanced aidriven analytics for fusing infrastructure monitoring data at different geospatial resolutions ontheedge sensory and communication technologies for local infrastructure monitoring a dynamic evaluation of infrastructure readiness solution in supporting the operation of ccam a road maintenance diagnosis and prognosis tool and lowcost smart signs with integrated electronics and embedded components for elicting desirable user behaviours are developed the approach is validated at 7 locations in spain italy latvia and romania addressing different types of infrastructure settings and road users in urban and rural environments interaction with existing programmes on roadmapping and recommendations at national eu and global level will be promoted allowing a multiplication effect of projects results
competitive and sustainable lithium solidstate battery technology enabling large scale production for automotive application

the growing energy demand aggravated by the high dependency on nonrenewable fossil fuels has severely impacted on climate change as evidenced by earths global average temperature increase in the last century road transport is responsible for around three quarters of transportrelated greenhouse gas ghg emissions thus decarbonization of this sector is necessary to achieve a climate neutrality battery electric vehicles bevs are a crucial enabler for accomplishing this target in this frame solidbat proposes a disruptive solidstate battery ssb technology to meet the challenging demands of the automotive sector the focus is on high energy density ssb 400 whkg 1000 whl enabling fast charging long life and safety to achieve these goals solidbat entails innovation in five main areas i digital tools and models for materials development and cell parameters design ii high capacity and water processable surface protected nickelrich nmc cathode active material iii 3dtexturized high energy lithium metal anode coated with a protective artificial solidelectrolyte interphase sei iv highly conductive and electrochemically stable hybrid gel polymer electrolyte hgpe crosslinked insitu and v scalable solutions for ssb technology manufacturing that are easily adaptable to current lithiumion technology thus hastening the introduction into the ev market moreover cost sustainability and recycling are prioritized along the whole project development in eg reducing raw material use and avoiding organic solvents for greener processing solidbats collaborative consortium spans the whole battery value chain fostering european innovation and industry growth by establishing ssb manufacturing in europe solidbat contributes to climateneutral energy and transport transitions as well as avoids the dependence of battery production on asian countries such as the current situation for liion technology
microgel technology for preservation of cultural heritage

this poc proposal is dedicated to the development of a new soft matter technology for paper preservation building on the recent erc grant of the pi mimic that was mainly a theoretical and numerical effort on modelling microgels in close synergy with experiments microtech proposes to exploit this fascinating class of soft colloids in a new application for cultural heritage microgels are colloidalscale polymer networks whose properties intrinsically depend on those of the constituent polymers while most studies deal with thermoresponsive ones here we propose to use gellan gum a widely used biopolymer since gellan gum hydrogels have been previously used to treat paper artifacts we recently showed the use of gellan gum microgels is more advantageous with respect to hydrogels both in terms of efficacy and of application timethe proposed technology is groundbreaking because it will significantly reduce the economic costs of the treatment it is environmentally friendly and also versatile indeed we will functionalize the gellan macromolecule in order to optimize the specific interactions with the different nature of the surfaces to be treated the main objectives of the interdisciplinary microtech project will be to optimize the preparation the functionalization and the longtime conservation of the microgels to validate the technology on real samples thanks to the collaborations with interested companies who already expressed their letters of support to perform a precommercialization study in terms of ipr and market analysis to create of network of potential partners and users finally to deliver a readytouse microgel formulation and a business plan therefore at the completion of the project we expect that the technology will be available to potential end users
transparent conductive oxide nanocrystalline films for electronics and optoelectronics via lowcost solution processing

tcotronics project aims at developing and bridging to the market a revolutionary concept of a lowcost solution process to fabricate transparent conductive oxidebased films optimized for optical electronic and optoelectronic applications we will fabricate multilayer photonic structures for filters and mirrors and transparent electrodes for visible solar cells and transparent electronic circuits we will employ only earthabundant elements we will scaleup the fabrication process developing and optimizing nanocrystal inks for printerstransparent conducting films tcfs are very important for many different applications including touch screens portable and flexible electronics optics multifunctional windows or solar cells the tcf market is anticipated to reach usd 102 billion by 2028 with a cagr growth of 98 in terms of value from 2020 to 2028 it is dominated by transparent conducting oxide tcos thin films for many decades now as tcos carefully balance electrical conductivity controlled by doping with other elements and optical transmittance nevertheless the ceramic nature of tco films make them often brittle and fragile and also their deposition conditions are not compatible with the printing of electronic components on flexible substrates this will ultimately affect the flexible and portable electronics sector and hence alternative fabrication protocols are desired also the optical properties of thin film oxides are important in particular the near and mid infrared wavelength range is becoming increasingly important for wireless communication biophotonics sensing or heat shieldinghence novel more costeffective processing techniques are required that replace the current deposition methods of oxides in general and tcos in particular and that result in similar optical and electric quality as the industrially wellestablished deposition techniques finding application as transparent electrodes and photonic structures
an innovative toolbox based on pdcatalysis for protease inhibitor synthesis applied to the discovery of panantiflaviviral compounds

protease inhibitors can potently block the viral replication cycle in the context of flaviviruses ns2bns3 protease is a promising viral drug target because of its well conserved backbone among flaviviral species opening the perspective of developing panantiflaviviral ns2bns3 inhibitors all reported ns2bns3 inhibitors however suffer from low potency andor poor biopharmaceutical properties structural optimization has proven to be slow and challenging in part because synthetic methodology for fast chemically versatile and diversityoriented modification is lacking to address these challenges we propose a methodology to assemble protease inhibitors with varying warheads and side chains in just 2 steps from common starting materials and apply it to the discovery of panantiflaviviral compounds first selected amidecarbamate and aldehyde building blocks will be condensed in a reported threecomponent reaction with phenylsulfinic acid and benzotriazole delivering individual masked nacylimines these will be further submitted to innovative crosscoupling steps in which warheads will be introduced once the methodology is optimized and the scope is determined at least 10 additional analogues of a known ns2bns3 inhibitor will be prepared with variations in the warhead p1 side chain and p2p3 moieties will be synthesized they will be subjected to enzymatic affinity determination binding kinetics analysis and cellular assays experimental data will be used to validate a molecular dynamics study of ns2bns3 inhibitors the project is envisaged to deliver significant societal scientific ri and economic impacts by managing flavivirus infections and creating business cases for industrial ri in europe
trustworthy methodologies open knowledge automated tools for security testing of iot software hardware ecosystems

telemetry will provide trustworthy tools that enable the continuous assessment of heterogenous interlinked components systems that constitute iot ecosystems interconnected iot devices with hardware software services and communications infrastructure addressing all aspects of their lifecycle the telemetry holistic methodology and toolkit incorporates testing for component development testing monitoring for component integration into systems testing monitoring for operation of systems telemetry will deliver advances in cybersecurity testing and runtime monitoring through the use of novel machine learning models and algorithms for realtime anomaly detection dynamic risk assessment to simulate likelihood and severity of threat consequences reputation management and privacypreserving data sharing across independent entities eg supply chains iot device emulation and analysis environment and lightweight approaches for trusted updates all of which that promotes a cycle of continuous improvement and assurance across design and runtime phases telemetry will leverage 3 exemplar use cases representing diverse complex iot ecosystems and iot supply chains in aerospace smart manufacturing and telecommunications domains to drive the design and validation of the proposed tools and methodologies this will lead to significant improvements with respect to accuracy of threat and vulnerability detection response time and cost of testing and verification of iot ecosystems telemetry will promote open source and knowledge sharing through engagement with relevant communities throughout the project for consultation dissemination and exploitation of its results
expert support to implementation working group 5 of the set plan energy efficiency in buildings

iwg5s brief is to deliver the implementation plan on energyefficient solutions for buildings requiring member states to put in place measures favouring both innovation in building design and energy technologies for buildings and the uptake of these technologies by builderseurac will offer scientific support establish the performance of ecobuilding technologies today and assist the iwg5 in setting realistic but ambitious performance targets then monitoring progress towards them wip will organise study tours to buildings that set the standard in ecorenovation or construction these will be opportunities for iwg5 members to meet the actors responsible and the people who live in or near them to collect their viewsectp and eurec will focus on informing iwg5 of the latest thinking around ecobuildings coming from lobbies ngos associations public authorities leaders of initiatives like the mission for 100 climateneutral cities by 2030 and building bridges to the thinkers in those lobbies digitisation is a major theme coming in the new proposed epbd we will align the epbds innovationrelated comitology committees with iwg5fed with ideas quantitative analysis and with white papers produced by task forces tackling specific innovationrelated topics the iwg5 will update its implementation plan a new release will come every year and be given lots of publicity the iwg5 members will be invited to promote it within their ministries in order to deliver it with appropriate national policiesiwg5csa will play close attention to the revision of national energy and climate plans in 2023 a joint activity with etips and depending on the final legislated epbd national building renovation plans in 2024 these plans are where member states lay out the policies to reach their targets we will work for takeup by countries of each others good ideas
uncovering the effects of pharmaceuticals in the wild beyond individuals to animal communities

the increasing production and release of pharmaceutical pollutants into waterways is now a leading threat to aquatic wildlife and ecosystems around the world despite this knowledge on the hazards these contaminants cause in complex natural ecosystems is still extremely poor and thus considered an urgent research priority aquadrugs will harness new developments in underwater animal tracking and computer automation to identify how pharmaceutical waste in the environment can induce behavioural changes in animals that lead to highorder ecological effects through a series of wellintegrated experiments and using fish as a model system aquadrugs will trace the impact of pharmaceuticals across biological scales to address four novel and ambitious objectives 1 test how environmentally relevant concentrations of two globally pervasive pharmaceuticals clobazam an tramadol both in isolation and in a mixture influence ecologically important wildlife behaviours and variability 2 identify whether and how such changes impact animal collectives 3 determine how pharmaceuticalinduced behavioural changes at the individual and group levels scale up to shape aquatic communities and 4 uncover how exposure shapes the ecological interactions of multiple species the project will deliver urgently needed data for chemicals regulation leading to improved policies that safeguard europes aquatic ecosystems and wildlife from pharmaceutical impacts the interdisciplinary approaches and theory in aquadrugsfrom integrative ecology ecotoxicology and analytical chemistryalso promises to yield pioneering results and experimental innovations that will advance these scientific fields and boost the expertise and academic career of the research fellow dr marcus michelangeli importantly the research in aquadrugs directly addresses key research priorities in europe including the european green deal and the eus mission for healthy oceans seas and inland waters
combined use of egnss and copernicus data to develop innovative downstream services for the users from chile and colombia

comunidad aims at developing testing and implementing a framework that will make use of copernicus data from agriculture forestry and rural development in chile and colombia it will develop solutions integrated on the comunidad platform with different sources of data the comunidad platform will be important base for the use of egnss and sharing of expertise with public and private entities from the target countries to introduce euspace based applications and to use of copernicus data to develop jointly algorithms services and products which serve local user needs the interaction with each pilot application in chile and colombia will feed to longterm policy strategy development aiming at bringing about the transition into the new paradigm of sustainable agriculture and forestry growth the combined use of egnss and copernicus to develop innovative downstream applications combining positing navigation and timing with earth observation services will be an essential part of the comunidad development through pilot applications in chile and colombia with the direct involvement of regional end users decision makers and support organisations this approach is not only demonstrating the possibilities of potential transfer of the results and addressing the potential barriers but as well introducing the added value for developing new markets information sharing open access and transparency the platform is combining existing components and services for new target regions where potential for utilization is expectedthe comunidad will address 4 main scientific objectives via 6 wps the cooperation of 9 partners is envisaged from them 5 are from chile and colombia and 4 from eu
investigating the neural ensembles underlying the encoding of memory in zebrafish

how animals respond to their environment largely depends on their past experiences in fact understanding how these subjective experiences are formed and how they influence behavior is one of the ultimate goals of neuroscience however how memories are established in the brain is still poorly understood in mammals and even less in primitive vertebrates although the formation of memory has been largely studied at the singleneuron level more recent studies have shown that the establishment of memory traces necessitates the interactions between multiple brain regions including the cortex amygdala and hippocampus yet imaging across these vast brain areas is very challenging in mammals due the complexity and size of the mammalian brain since there are accumulating evidence illustrating that the hippocampus and amygdala are evolutionary conserved across vertebrates here i will use an optically transparent and genetically amenable vertebrate model that allows for brainwide imaging of neural activity the juvenile zebrafish first i will use electrophysiological and immunochemical methods to identify the major neuronal populations in the fishs hippocampal homologue wp1 next i will use a combination of electrophysiological recordings and wholebrain twophoton calcium imaging to investigate the connectivity architecture and synaptic organization of the neural ensembles of the hippocampal homologue in zebrafish brain explants wp2 finally i will characterize what kind of information does the hippocampal homologue encode during learning and how does the brainwide neural activity changes over the course of learning in behaving animals wp3 collectively this project will identify for the first time key fundamental neural mechanisms that underlie memory formation across vertebrates and will provide a basis for future projects seeking to study complex neural computations in primitive species
scalable and sustainable pilot line based on innovative manufacturing technologies towards the industrialisation of solidstate batteries for the automotive sector

spinmate aims to demonstrate a scalable sustainable safe and costeffective digitaldriven proofofconcept pilot line at a trl6 level as a first step towards the largescale manufacturing of generation 4b gen 4b ssb cells and module in order to support the electrification of the automotive sector to do so spinmate proposes the development and implementation of innovative and scalable manufacturing and processing solutions notchingcutting stacking and sealingpackaging steps among others furthermore new industry 40 and 50 concepts industrial internet of things iiot and machine learning ml algorithms digital twins gigafactory line simulation are proposed to be applied for the digitalisation of the proofofconcept pilot line as well as the assembly and manufacturing processesthus spinmate will manufacture small 1 ah and large 10 ah ssb cells after the development and optimisation of i advanced solid polymer electrolyte with high ionic conductivity and wide electrochemical stability ii li metal foil with surface treatment enabling a more stable interface as anode and iii nirich layered oxide cathode with improved cycling stability regarding electrodes ie anode and cathode and electrolyte processing innovative solventfree extrusion routes rolltoroll approach and optimised solvent casting methods are suggestedspinmates gen 4b ssb cells will create a new industry value chain in europe towards their commercialisation this new generation technology will ensure i enhanced energy densities overcoming current lib limitations ii improved safety in both solutions and workers iii increased sustainable mass production and iv decreased carbon footprint and cost