Dragon09/odtu_chatbot huggingface dataset:
neolithic coastal settlements and responses to environmental dynamics a pioneering world lost beneath the mediterranean sea

coastal societies hold a vital place in mediterranean history many of their earliest trajectories however are archaeologically obscure due to a rise in sea levels since the last ice age beforetheflood is based on an observation that before it was inundated the mediterranean littoral was extremely dynamic eg formationretreat of marshes increased soil salinity rapidly rising sea levels necessitating constant reactions by its inhabitants this project aims to study how neolithic coastal societies in the eastern mediterranean pioneered cultural responses to environmental changes and how these enabled the development of mediterranean complex societies the earliest known mediterranean coastal settlements and their paleolandscapes now situated offshore along the carmel coast israel will be studied by drilling sediment cores and through underwater excavations followed by microscopic and chemical analysis in the laboratory that will integrate geoarchaeology bioarchaeology and paleoenvironmental reconstructions the projects novelty lies in its approach which will generate a highresolution diachronic model of how hyperlocalised environmental dynamics are directly related to archaeological evidence of adaptive solutions the project will test how neolithic coastal communities constantly readapted to dynamic environmental processes over time by modifying their environment and developing new technologies and social interactions ie negotiations with inland farmers that fostered the establishment of a unique mediterranean coastal society beforetheflood will elucidate an important and asyet unread chapter of a world now lost beneath the sea one that will help to rewrite the early story of the eastern mediterranean coast as the springboard for innovation adaptation and connectivity that set the scene for the development of later mediterranean complex societies
europes rail flagship project 6 delivering innovative rail services to revitalise capillary lines and regional rail services

regional railway lines with lower usage or secondary network plays a crucial role not only in serving european regions but also as feeders for passenger and freight traffic for the maincore network therefore they have an essential function as an environmentally friendly mode of transport in addition is as well essential their link to other public transport services eg bus and to first and last mile services such as bikesharing cycling walking or driving to get fromto stations to remote locations unfortunately many of these routes were abandoned in the past mainly due to high costs therefore these rail lines need to be revitalized or even renewed to make them economically socially and environmentally sustainable and to meet current customer needs and challengesthe overall objectives of the future project are to ensure the longterm viability of the regional railway by reducing the total cost of ownership tco while ensuring high service quality and operational reliability it also aims to increase customer satisfaction and to make rail an attractive and preferred mode of transport therefore the main objectives of future are lowering capex system costs increasing productivity by lowering opex unit costs per train kilometre and improving customer satisfactionthese goals are to be achieved through a concept tailored to regional railways but transferable across europe encompassing digitalisation automation and the use of common and new technologies for signalling and track components rolling stock and customer information cost drivers such as infrastructure and energy components eg trackside train detection axle counters etc and level crossing control systems will be replaced by less costly wireless and energyautonomous components in addition a modular and standardised vehicle concept specifically tailored to the requirements of regional lines becomes needed as well as a range of attractive services
implemented synergies data sharing contracts and goals between transport modes and air tansportation

signair will develop and pilot a new platform for an orchestrated sharing of data in multimodal traveling the platform will provide the means for transport service providers tsps to register reach data sharing agreements with other tsps and manage their contractual relationships while the signair platform will only manage the contractual aspects through the types of data offered by the tsps the tsps will continue managing their data and that of their customers as an added value the signair platform will provide a number of advantages and services to the stakeholders of multimodal travel for the b2b2c chain through the analysis and exploitation of the contracts i templates for contracts to simplify the legal management ii electronic management and information provision about each specific contract iii routing information for travel companions tcs with enriched information about the specific contracts for their traveler customers and iv facilitation of single ticketing through the comprehensive understanding of the contracts and the data managed among othersthe whole concept will be moved from trl2 reached by the mother project synair to trl 7 this will be done with an intensive evolution of the software and a continuous evaluation and piloting of the software with different important stakeholders that are present in the consortium the development of the software will generate a minimum valuable product in the first 12 months of the project and in parallel it will be piloted and improved through continuous development of the technologies in the following 21 months reaching a trl7 platform in month 33 of the projectthe partnership is formed by knowledgeable teams in the areas of it legal and mobility including airports tsps and transport authorities on the piloting side
combining artificial intelligence and smart sensing toward better management and improved quality of life in chronic obstructive pulmonary disease

chronic obstructive pulmonary disease copd is a highly prevalent chronic condition while copd is a lung disease it is mainly the exacerbations and extrapulmonary comorbidities which affect the quality of life health care costs and prognosis the optimal copd treatment needs to focus on both the characteristics and consequences of the lung disease itself and the diagnosis and treatment of comorbidities while the severity of lung function impairment is routinely assessed the exacerbations the associated comorbidities and limitations in daily life are still significantly underestimated a personalized approach to copd management is needed to specifically address the disease prevent exacerbations and mitigate its comorbidities to obtain a positive impact on patient health and quality of life tolife will clinically validate an artificial intelligence ai solution to process daily life patient data captured by unobtrusive sensors to enable optimised personalised treatment assessment of health outcomes and improved quality of life in copd patients the tolife approach to copd management targeted to predict and mitigate exacerbations and continuously assess the health outcomes has the potential to reduce mortality improve health related quality of life and reduce the healthcare coststolife will develop and clinically validate an aibased platform for the early prediction of exacerbations and assessment of the health outcomes prediction of exacerbations and assessment of health outcomes will be exploited by clinicians through a patient management tool to perform early and personalized treatment tolife platform will inform through a disease information tool the patient and caregivers about the patients health status the specific treatment plan and lifestyle indications two clinical studies will be implemented one to collect data for aitools development and the other to validate the effectiveness of tolife to reduce the risk of exacerbations
towards an artificial cognitive science

with the advent of capable artificial agents comes the urgency to improve our understanding of how they learn reason and decide this proposal aims to shape a new field of artificial cognitive science in which tools from cognitive psychology are used to understand and improve the behavior of the notoriously opaque artificial agents to which we increasingly delegate autonomy and authority we will focus on the newlyemerged disruptive and increasingly powerful foundation models huge neural networks with billion of parameters that are trained on hundreds of billions of words and study them using tools from cognitive psychology we will subject these models to experimental paradigms from the psychological literature and analyze their trialbytrial behavior using detailed computational modeling psychological paradigms have been engineered to uncover precisely the mechanisms that underpin behavior we will use cognitive psychology to study and improve prompt engineering ie the design of textual inputs to these models that lead to a desired behavior afterward we will build large cognitive benchmarks to assess foundation models learning decisionmaking and reasoning abilities in both the pure language and the combined language and vision domains finally we will attempt to improve these models behavior using cognitive therapy this proposal will help to create transparent and humanlike agents and define an innovative and interdisciplinary research field in which cognitive psychologists and artificial intelligence researchers jointly examine and improve intelligent systems
biophysical investigation of the liquidliquid phase separation solvent interface

liquidliquid phase separation llps is central to compartmentalisation of biochemical processes and allows colocalisation of a whole biological machine and its substrates at high local concentrations this often dynamic and reversible assembly is formed by multivalent interactions between several biomolecules and some instances involve low complexity sequences that have been linked to amyloid fibre formation while the biophysical understanding of this phenomenon has recently been of high interest in the scientific community the interactions of llpsforming proteins from the dilute phase with the interface to the condensed phase remain elusive in this project we aim to dissect these transient interactions using stateoftheart biophysical techniques more specifically we will use nuclear magnetic resonance nmr highresolutionrelaxometry hrr and an array of singlemolecule fluorescence techniques to dissect up to atomic resolution and at multiple timescales the transient interactions of the dilute phase proteins with the interface of the condensed state we shall rely on the nonhomologous end joining nhej system that our laboratory has recently shown to exhibit llps in a broad range of conditions atomiclevel dynamic information on the mechanisms for nhej phase separation and assembly could prove crucial both in the fundamental understanding of llps formation and growth and in rational drug design aimed at preventing doublestrand break repair by nhej in the frame of cancer treatment
biodiversity and trade mitigating the impacts of nonfood biomass global supply chains

despite its importance biodiversity is at a high risk of a 6th mass extinction widespread trade networks spanning our globe allow consumption in one part of the world to cause biodiversity impacts elsewhere unfortunately we have limited and incomplete tools for assessing the impacts of trade on biodiversity which hampers mitigating these losses for policymakers retailers and other stakeholders in bamboo we want to rectify this situation with a focus on nonfood biomass we will develop models to quantify biodiversity impacts using four indicators species richness mean species abundance functional diversity and ecosystem services we will use lcimpact and globio for impact categories that already exist but update them to the newest state more importantly we will complement them with novel impact categories to cover impacts across the terrestrial freshwater and marine realmswe will create a new hybrid multiregional inputoutput mrio model based on the wellknown exiobase and the biomassspecific fabio models this mrio model will be linked to our impact assessment methods and the integrated assessment model image for scenario generation to assess global trade and identify potential leverage points for halting and reversing biodiversity loss now and under future scenarios apart from global assessments and recommendations we will test our models on two local case studies fishmeal production in peru and cotton production in tanzaniato maximize our outreach we plan to develop an online tool that will allow stakeholders to use all models easily in general our models will be freely available on zenodooverall bamboo will provide comprehensive and detailed knowledge of the effects of biomass trade from land and sea on biodiversity and ecosystem services and an improved way of identifying leverage points this will ultimately contribute to better environmental decisionmaking supporting to reach sciencebased targets and the sdgs
the oater develops a compact machine for hyperlocal fresh oat milk production to reduce waste and emissions

the oater is a femalefounded food tech startup from germany that develops a compact machine for hyperlocal fresh oat milk production to reduce waste and emissions the founding team cothe oater is a femalefounded food tech startup from germany that develops a compact machine for hyperlocal fresh oat milk production to reduce waste and emissions the founding team consists of four members led by ceo and head of hardware sarah nesti with lisa nesti cmo and henrik burger cfo in the business team and benjamin auer cto as the process engineer this diverse team is perfectly equipped to create a successful business the founders gained prior startup experience in a b2b ecommerce business launched in 2020 with over 30 customers and 30k euro revenue the entire team consists of 9 members including two marketing experts two business assistants and a product designerthe oaters goal is to inspires sustainable consumption to protect and enrich life for all generations to come we want to achieve this by downsizing the industrial production into a compact machine for local production of fresh oat milk this doesnt only improve taste but also lowers costs and reduces the environmental impact by producing the oat milk at the point of sale packaging is eliminated and transport emissions are significantly reduced due to the fact that oat milk is 90 water the oaters business model is oat milk as a service meaning that b2b customers borrow the machine for free and only pay by liter for the oater packages which consist of the ingredients needed to produce the oat milk in the machine this model ensures constant delivery profits and scaleup as hardware profits are negligible compared to delivery service the oater provides a holistic ecosystem solution consisting of the iot machine frequent replenishments and a smart online platform the main objectives are to introduce customers into our ecosystem simplify entry and make oat milk exciting at the pos
formmeaning mappings in language

mapping linguistic forms such as the word cat to their corresponding meanings such as the concept of a cat is a fundamental property of language in an ideal scenario this mapping occurs on a onetoone basis where each form uniquely corresponds to a specific meaning and vice versa however there are instances where this neat onetoone relationship breaks down and a single form takes on multiple meanings this intriguing phenomenon is the primary focus of the fomeproject the central objective of the fomeproject is to delve into how native speakers articulate their thoughts desires regrets and other cognitive nuances through clausal complementation specifically the project aims to explore the intricate ways in which individuals indicate the extent to which their statements contain familiar or new information established facts or conjectures this exploration will be grounded in two key approaches a insights derived from studying microvariation in modern greek dialects and macrovariation across diverse languages and b utilization of an array of methodological tools encompassing fieldwork experimental research involving questionnaires statistical analyses and selfpaced reading tasks examination of diachronic syntax and engagement with theoretical linguistics through this comprehensive investigation the fomeproject seeks to illuminate critical questions these questions encompass the intercomparability of different languages the boundaries of human perception and cognition that can be encoded within grammatical structures and the intricate pathways through which these aspects gradually evolve into grammatical forms
targeted immunocytokines by caging and local release

immune therapies have caused a paradigm shift in the treatment of melanoma and leukemias however the broad immune therapies have caused a paradigm shift in the treatment of melanoma and leukemias however the broad application of these immune therapies to all cancers has not worked one of the major reason for this failure is the presence of innate immune suppressive cell types in many tumour types such as macrophages nk dendritic and myeloid cells tumour selective reactivation of these cells is considered one of the holy grails for the future of immune therapy most endeavours in achieving this are severely hampered by the toxicity of innate immune activators they cause strong offsiteontarget systemic immune activation which can lead sepsislike symptoms and death developing innate immune activating therapies that are both powerful and safe are therefore key to applying immune therapies across the cancer landscape as part of my erccoggrant i have developed innnate immune activators that are chemically blocked but that can be reactivated locally to offer this approach can potentially serve as exactly the safe and potent innate activator required by targeting the innate activators to the tumour and only activating them once they have accumulated there we can decouple the therapeutic activity from the systemic toxicity that plagues these approaches in this proposal we aim to evaluate the first such a caged innate immune activator in a preclinical cancer model we will validate its potency pharmacokinetics and cagingdecaging behaviour in addition we will broaden the scope of the innate activators antibodies and uncaging chemistries that can be applied we will also perform market research to determine the optimal tumourimmune activatorantibody combination to take forward into clinical development and begin to take the necessary steps to spin out a company based on this work to bring these nontoxic innate activators to the clinic
polyphonic philosophy logic in the long twelfth century c 10701220 for a new horizon in the history of philosophy

this project aims at an innovative interdisciplinary approach to latin logical commentaries from the long twelfthcentury c 10701220 my contention is that this littleexplored topic presents us with a unique polyphonic philosophy that can open up a new horizon in our understanding of philosophical commentaries on the one hand and help to reshape some core ideas in the history of philosophy on the other at a time when both are urgently needed a team of four postdoctoral researchers led by the pi will actualise the potential of some extraordinary preliminary material to study a wealth of 12thcentury manuscripts of mainly unpublished texts with novel concepts we will have three objectives 1 a comprehensive study of 12thcentury logical manuscripts as the main units for accessing this complex field in which the notions of unitary text and author have proven challenging 2 a study of mainly unpublished logical texts from a polyphonic perspective that will follow a comparative archaeological and analytical approach and develop some pioneering digital scholarly editions of texts to model their polyphony 3 metaanalysis of the concepts used from an interdisciplinary and historiographical perspective offering new insights into the key concepts of the project and nonsolo paradigms to reconstruct philosophys past the project will require interdisciplinary expertise in digital medieval studies digital textual criticism codicology the history of education the history of literacy the social history of logic the history of philosophy and the historiography of philosophy following a concretetoabstract highly integrated research design taking advantage of recent methodologies this project has the ambitious goal of opening up an entirely new horizon for the history of philosophy while also impacting on several other areas from medieval studies to the history of universities to the study of commentaries more generally
investigating energyenvironmenteconomic growth linkage for sustainability in subsaharan africa

energy consumption environment and economic growth target variables exist simultaneously and are inseparable this means energy access is essential to spurring economic growth and reducing poverty however it adversely affects the environment besides there is a negative relationship between environmental degradation and economic growth thus this tension between improving energy access for economic growth and mitigating environmental externality from growth introduced a threeway link model and their interaction impact on sustainable development is the recent research agenda however previous findings examined either one or twoway links supply side demand side or environmental side theories to explore the relationship between the variables most findings overlooked the interaction impact on sustainable development and did not measured the variables in broad or specific indicators resulting in a gap in the literature knowledge furthermore the forward and feedback relationships between economic activities and the environment have not been examined therefore this study will investigate target variables linkage and their interaction impacts on the sustainable development of subsaharan african countries from 2001 to 2023 the study will employ multicountry secondary panel data analysis collected from international institutions databases it will analyze the descriptive statistics and basic panel data econometric tests and adopt the abovementioned theories capital approach and integrated sustainable development goals isdg framework and employ robust methodology like the simultaneous equation model it will provide insights into the complex relationship between target variables inform policymakers on sustainable development strategies and serve as a basis for further studies the project will also encourage investment in renewable energy and conservation the fellowship will enhance research skills visibility networking and vu capacity