Dragon09/odtu_chatbot huggingface dataset:
impact of gut microbiota targeted dietary intervention on obesity a precision medicine approach

the main objective is to analyze the impact of dietary hypocaloric interventions based on their capacity to generate ketone bodies in different degrees of intensity using intermittent fasting ketodiet in comparison with the classical meddiet in individuals with obesity and their influences on the gut microbiota resistome host metabolism and the possible genetic and epigenetics links we aim to contribute with the advance in the development of a precision medicine approach in obesity to decrease the prevalence of obesity and its associated comorbidities and to evaluate the impact of dietary interventions as an alternative approach to antimicrobial resistanceto achieve our goal we will study in a randomized crossover group of individuals with obesity a analyse the effect of dietary interventions meddiet intermittent fasting if and ketodiet on the gut microbiota composition and the relationship with anthropometrics metabolic inflammatory and epigenetics driven factors at short term 1 month b analyse the effect of dietary interventions meddiet if ketodiet on the gut microbiota composition and the relationship with epigenetics factors at mediumterm3 months c evaluate the impact of the gut microbiota targeted dietary interventions meddiet if and ketodiet at short and mediumterm on the gut resistome and relate it with the inflammatory milieu of the hostour results will help to improve the treatment of metabolic diseases associated to obesity using a precision medicine approach based on the influence of diet interventions on the gut microbiota gut resistome host response and environmental factors the outcome of this project will have an impact in the health sector by improving mental health and physical health of all overweight and obese individuals in the economy sector by reducing the need of surgical approaches to achieve weight loss reducing the risk of development obesityrelated complications and overuse of antimicrobials
how the legitimacy of watermanagement models as decision support tools gets established

models facilitate anticipatory governance a prominent example is the use of climate models to support the paris agreement but models are not neutral they conceal valueladen choices such as in how model approaches are selected or model applications are framed this implies that certain perspectives are favoured by the model since decisions based on such valueladen models have realworld consequences it is essential to understand how these models obtained the legitimacy to serve as policy advisors the model code itself reveals only the tip of the iceberg because it does not show the negotiations before the model was established therefore the legit project aims to uncover the factors and processes through which especially watermanagement models acquire legitimacy to support decisions and to develop theory on establishing legitimacy to achieve this goal my team and i scrutinize three case studies and explore the socialpoliticalinstitutional the sociotechnical and the simulation perspective through respectively policy document analysis and interviews with decisionmakers model documentation analysis interviews with modellers and ethnographic observations of modellers and extensive uncertainty analysis of model applications this rich collection of data allows to formulate a preliminary theory of legitimacy of watermanagement models as decision support tools this theory will be further refined based on a serious game that mimics relevant actors and decision processes legit starts from a strong empirical stance with the aim to understand modelling in anticipatory governance legits theory will enhance insights on concealed values in such models and allows for indepth discussion of their policy application but more importantly legit explains how a model got authority despite its concealed values this paves the way to more transparency in the process of using models as decision support tools thereby contributing to a stronger democracy
open digital environment for hybridelectric regional architectures

the objective of the open digital environment for hybridelectric regional architectures ode4hera project is to enable and accelerate the development of hybridelectric regional her aircraft thanks to improved tools and techniques implemented in a transferable and open digital platform odpher configurations imply far higher complexity than conventional configurations while involving new aircraft technologies and broader collaboration across the valuesupply chain stateoftheart digitalization techniques limitations put at risk the achievement of the 2035 her entryintoservice eis target to address these challenges the odp developed in ode4hera will combine mbse mdo sdm and plm technologies and extend them with novel open interfaces formats smart model and data transformation technologies efficiently handling and processing her configurations complexity including frontload verification at design stage and virtualize validation for improved virtual certification
identifying mechanisms and novel treatments of bone pain closing the gap to the clinic

musculoskeletal pain from diseases such as arthritis and cancer in the bone affects the quality of life of millions and is a major societal burden the current treatment options are opioids nonsteroid antiinflammatory drugs and disease modifying drugs however these are often insufficient in providing an adequate pain relief this is due to dose limiting side effects the risk of misuse and addiction opioids and lack of efficacy thus there is a strong unmet medical need drug development in pain has been hampered by a poor translation of preclinical data to the clinic and a lack of understanding of the underlying mechanisms therefore in this project 4 academic beneficiaries 3 industrial beneficiaries 2 industrial partners and 3 academic partners join forces to create an outstanding and integrated training program for early stages researchers to increase the clinical translation of bone pain research and drug discovery and to provide novel mechanistic insight and potential therapeutic targets we will develop fully humanized organona chip models of the painful bone disease microenvironment and we will use humanized mouse models and tissue and liquid biopsies from patients to obtain clinically relevant data moreover we will identify new disease mechanisms and potential treatment targets and explore the efficacy of clinical stage therapeutics in mouse models of the painful skeletal diseases osteoarthritis rheumatoid arthritis cancer in the bone and the rare bone disease fibrous dysplasia in an extensive training effort covering both specific research skills and transferable skills the students will obtain an interdisciplinary stateoftheart and innovative training from the participants across sectors the students will benefit from secondments with industrial partners and with some of the foremost pain researchers in europe
plant based 4d biohybrid systems

modern technology relies on fully artificial systems while in many cases these systems are high performing there have been approaches to add further complexity or intelligence inspired by natural processes biomimetic systems however are purely synthetic and cannot fully mimic the high complexity of living systemsthe overall goal of the 4dphytohybrid is to develop photosynthetic biohybrid systems that maintain fundamental properties of the living components and set the foundation for the development of a generic hybrid technology the biohybrid system will consist of four dimensions with increasing level of complexity and sophistication the first dimension consists of the plant cells with their natural ability to photosynthesize and produce sugars oxygen sequester co2 but also produce materials as cell wall components the second dimension is represented by the nonnative functionality of the living cells that is acquired with electronic biocatalytic and structural materials that integrate into the plant cell wall the third dimension is the 3d spatial organization of cells and physicochemical gradients with additive manufacturing the fourth dimension is time that will enable responsive and evolvable functionality of the biohybrid system driven by the cell processes i have a background in organic electronic materials bioelectronics and plant based biohybrid systems i was the first to demonstrate plants with augmented electronic functionality but also to discover conjugate oligomers that can polymerized in vivo by the plant and assemble into functional components in the plant cell wall my unique skillset and expertise will therefore ensure the successful implementation of the proposed high risk high gain project with the erc funding i will establish a team for developing next generation technology based on photosynthetic biohybrid systems in order to open the pathway for new technological concepts and launch a european hub for living technology
multimodal quantitative phase microscopy

quantitative phase microscopies qpms experienced a strong gain of interest this last decade expecially for bioimaging applications mapping the phase of a light beam enables biologists to enhance the contrast of live cells in culture without invasive fluorescent labelling it also enables the unprecedented capability of qpms to accurately measure the biomass of live cells observed by optical microscopy this capability out of reach using fluorescence microscopy yields an accurate control of the growth rate of cells in culturequadriwave lateral shearing interferometry is a highresolution wavefront sensing technique that has been used as a qpm for 10 years it represents a simple yet robust and accurate qpm that has already been applied not only in biology but also in nanophotonics for the first time by the pi to characterize objects such as nanoparticles 2d materials and metasurfaces expanding the range of application of qlsihowever like any other qpm technique qlsi is based on the assumption that the imaged light field is scalar while this assumption is fine for some applications for others it yields a loss of information because qpms do not capture the whole information a beam can containin the multiphase project we wish to expand the capabilities of qlsi by developing an experimental methodology to retrieve the polarization information of the light field in intensity and phase the applicability of this new methodology will be tested and illustrated by conducting proofofconcept experiments related to applications in nanophotonics and biomicroscopy finally a software to pilot the system will be developed
photonics from research to market empowering europes strategic autonomy supporting the green deal and securing resilience photonics21

phorwards21 will create and implement a comprehensive industrial strategy for photonics in europe the action will be implemented by photonics21 the eu commissions partner in the horizon europe photonics partnership with its more than 3000 members from companies and research institutions as well as national photonics technology platforms and regional clusters in addition to already initiated collaborations with enduser and other deeptech partnerships contacts with national ministries photonics21 mirror group and financial actors such as the european investment bank eib the european investment council eic and corporate venture capital companies will be strengthened to implement the european photonics strategy and thus establish european strategic autonomy in this critical technology specific enduser communitybased roadmaps will be developed focusing not only on research priorities but also on industrial implementation including pilot lines and the creation of appropriate framework conditions
cybersecurity excellence hub in estonia and south moravia

the proposed cybersecurity excellence hub in estonia and south moravia chess will integrate leading cybersecurity institutions and capitalize on the strengths of both regions to address important europewide challenges south moravia is a major ict industry education powerhouse of the czech republic with a very focused and coherent smart specialization strategy targeting cybersecurity estonia is among the most advanced digital societies globally with exceptional egovernment deployment which however makes it vulnerable to various cyber threats chess will directly follow the strategies and roadmaps of the european cybersecurity competence pilots and build on the experience of chess partners involved in all four of these pilots contributing to safe transition of the eu to fullscale digital society the chess hub will conduct a thorough needs analysis of the two regions and develop a joint crossborder ri strategy for cybersecurity the strategy development will be aided by implementation of pilot ri projects that will reinforce the crossregional collaboration engage regional innovation ecosystems and build evidence for future projects gaps in skills and expertise identified in the regions will be removed by training and knowledge transfer finally dedicated task forces will ensure sustainability of chess by integration with regional national and eulevel strategies and funding programmes to exploit the project outputs especially the pilot project results chess will aid with market potential assessment and link researchers and innovators with entrepreneurship training and business consultancy services available in the regions the strategizing skillsbuilding and pilot ri will cover the totality of the cybersecurity field with special attention to 6 challenge areas internet of secure things security certification verification of trustworthy software blockchain postquantum cryptography and humancentric aspects of cybersecurity
optical circuit switched time sensitive network architecture for highspeed passive optical networks and next generation ultradynamic and reconfigurable central office environments

skyrocketing capacity demands and emerging 5g and industrial internet urllc applications currently pose a new strict latencyoriented framework calling urgently for new radical architectural changes at the key aggregation infrastructure being in local proximity to the subscribers the central offices cos a careful look into the co reveals a capacitylatency predicament underlining the need for the employment of innovative technological solutions with photonics emerging as the key enabling technology that will establish a new ngco ecosystem where componentlevel advancements can yield unparallel architectural benefits octapus aims to deliver an agile lowcost and energyefficient pic technology framework that will rearchitect the ngco ecosystem transparently upgrading its capacity to 512tbs and beyond through an innovative opticallyswitched backplane and transceiver toolkit to realize its ambitious goals octapus will leverage the novel integration of antimonybased phase change materials pcm on the lowcost sin to develop for the first time a nonvolatile nsscale optical switch technology for developing an ultrahigh capacity optical backplane octapus will also deploy a versatile portfolio of inpbased oband optical components that will enable the realization of 50g lowpower boardtoboard and longreach pon transceivers securing 4x and 8x energy saving to existing stateoftheart solutions while reaching up to 375 cost improvement against conventional eml solutions through its monolithic fabrication approach moreover octapus will equip its novel pics with low loss and compact interfaces to fibers through advanced glass diplexerembeddedinterposers finally octapus will synergize the developed optical components in a novel ngco architecture supporting 3 layers of traffic with deterministic latency guarantees for urllc services through the incorporation of reconfigurable express light paths along with tsn functionality
streamlining geo mapping and early monitoring with an allinone data collection system for power line and mining industries

power line and mining industries face challenges related to vegetation encroachmentand infrastructure monitoring the inefficient monitoring of vegetation growth near power lines increases the risk of wildfires while inadequate monitoring of mining infrastructure can lead to safety hazards and operational inefficiencies the current solutions are often inefficient due to their high operational costs timeconsumption and lowquality output since most of them are custom built for the specific application of end usertherefore by combining advanced sensor fusion technology and realtime monitoring aispeco innovation imc aerie offers a comprehensive and costefficient solution the systems controller allows integration of various sensors creating a live digital twin enabling efficient vegetation management and infrastructure integrity eliminating wildfire and slopes sliding risks offering safety improved operational efficiency it follows principles of digitalization and implements industry 50 standards european green deal reducing ghg black carbon emissions and contributes to sdgs
mountbuzz relating contextdependent beeflower interactions to macroevolution

adaptive evolution of flowers to optimize pollen transfer by animal pollinators is considered a key driver of plant speciation and the success of flowering plants plantpollinator interactions are embedded in complex abiotic climatic and biotic other plantspollinators contexts and the structure and function of interaction networks changes across such contexts to date however we lack a broadscale perspective on how these contexts affect which flower phenotypes are fit and how flowers evolve to adapt to these contexts this knowledge gap limits our understanding of the processes that generate and maintain biodiversity critically important in light of current global changein mountbuzz i aim at developing a novel contextdependent ecological perspective on the processes structuring the evolution of flower diversity by linking the commonly separated fields of community ecology and macroevolutionary modelling first to determine which flower phenotypes are fit high reproductive success in different abiotic environmental contexts my team and i will analyze plantpollinator interactions and flower and pollinator trait data along four elevational gradients across the tropics we will combine empirical field observations with pollination experiments to pinpoint contextdependent changes in phenotypefitness relationships second synthesizing across these results we will test whether patterns of flower macroevolution follow predictable contextdependent trajectories by employing machinelearning based predictive modelling and phylogenetic comparative methodsthe results of mountbuzz will deliver a new perspective on the relative importance of pollinatormediated selection and environmentdependent processes in driving flower evolution and plant diversification my study setup crosscontinental crossenvironmental crosslineages further allows for identifying generalities in patterns thereby delivering novel hypotheses for future research
the langlands correspondence

r langlands conjectured the existence of a correspondence between automorphic spectrums of hecke algebras and representations of galois groups of global fields the existence of such correspondence is one of the main conjectures in mathematics even if not known in full generality it leads to proofs of ferma and satotate conjectures this project is on three aspects of the langlands correspondence the first part of this project is a description of the spectrum of hecke algebras on the space generated by pseudo eisenstein series of cuspidal automorphic forms of levi subgroups in the simplest nontrivial case the precise description is a conjecture of langlands this conjecture is proven in my work with a okounkov by an unexpected topological interpretation i expect this approach to work in a number of other cases the second part of this project is an extension of the langlands correspondence to a completely new area of fields of rational functions on curves over local fields this extension of the langlands correspondence to a new area could lead to new interplays between representation theory and number theorythe third part of the project is on a categorification of the langlands correspondence necessary for establishing the strong form of this correspondence
doing charges right modelling ioncontrolled biological processes with the correct toolbox

electrical stimuli are essential for a plethora of biological functions unlike in electronics where electrons form currents nature rather exploits ions as charge carriers lack of a consistent molecular picture of action of ions impairs progress in fundamental understanding of ioncontrolled biological processes and in designing smart strategies for fixing ionrelated pathological conditions molecular simulations represent a powerful tool for modelling such processes however they can only be as good as is the underlying interaction model force field a major drawback of commonly used force fields is the lack of description of electronic polarization which results in severe artifacts such as a dramatic overbinding of ions preventing eg accurate modelling of calcium signalling processes this now wellrecognized deficiency hampers faithful modelling of complex ioninvolving biological processeswe will employ machine learning techniques to build a de novo comprehensive force field for biological systems that accounts for electronic polarization in a mean field way via charge scaling this approach will qualitatively improve modelling of ions in biological contexts without additional computational costs this will allow us to address accurately the following highly relevant ionspecific processes of increasing complexity from molecular over cellular to organ levels1 dissolution of radical anions of aromatic molecules as key intermediates in technologically and biologically important nonenzymatic and enzymatic birch reduction processes2 direct membrane translocation of cationic cell penetrating peptides with a potential of drug delivery 3 circulation of calcium ions as signalling charge carriers through ion channels of hair cells in the cochleaat the same time the newly developed charge scaled force field will be made freely available to the community for further development and ready to be used within major simulation program packages