Dragon09/odtu_chatbot huggingface dataset:
menstrual migraine understanding its pathophysiology and developing precision treatment strategies

females experience 3 times more migraine attacks than males with menstrual migraine affecting 60 of these females they occur before or during menses and are associated with oestrogen e2 withdrawal dramatically affecting a patients quality of life menstrual migraines are poorly understood limiting novel treatment strategy discovery recently i demonstrated that e2 withdrawal increases the function and forward membrane trafficking of specific potassium channels kv7 in systemic arteries if present within the cerebrovascular system e2 withdrawal will increase sensitivity to endogenous migraineinducing vasodilators such as calcitonin generelated peptide cgrp contributing to migraine onsetthis project is split into two objectives 1 investigate oestrus cycledependent changes in rodent cerebrovascular reactivity via molecular functional and electrophysiological techniques with a focus on e2 mediated changes in kv7 subcellular trafficking via novel gprotein coupled oestrogen receptor gper1 2 translate preclinical basic science research generated in objective 1 into a model of mensural migraine international collaboration with prof geoffrey abbott at the university of california irvine allows for access to in vivo hemodynamic perturbation monitoring hpm and a novel crisprcas9 kv7 knockout rat hpm allows for simultaneous measurement of cerebral blood flow and migraine onset induced by cgrp we will investigating if female rats are more susceptible to migraine induction when e2 is low and and whether they are protected from migraine induction by gper1 stimulation or kv7 knockoutour project has the potential to reveal novel pathophysiological mechanisms underlying menstrual migraine allowing the development of novel precision treatment strategies my hosts and i are experts in the field of vascular kv7 physiology and are the ideal candidates to carry out this project
robust simulation systems exploiting ai based turbulence models and hightfidelity algorithms

to meet global eu objectives related to aeronautical industry competitiveness and climateneutrality highly advanced design technologies are needed to allow fast and reliable evaluations of innovative configurations rosas aims at exploiting artificial intelligence aimachine learning ml coupled with recent advances in computational fluid dynamics cfd technology and the underlying turbulence modelling to reduce expensive and timeconsuming physical testing and drastically accelerate the whole design optimization processpartners will build a methodology based on defining test cases targeting the key flow problems encountered in industrial applications and reproducing them precisely in a controlled environment via hifi simulations or experiments the results will be gathered in a database which will serve the development and testing of novel datadriven methodologies aiml and mesh generation algorithms improved turbulence models including multifidelity surrogate models with advanced verification and validation process will be created with modifications based on new theoretical considerations and aimlbased modifications resulting in hybridization of specific turbulence models in addition application challenge test cases will be defined in relation to clean aviation applications to match closely industrial configurations of interest to assess and demonstrate the new methodologies developed in the projectrosas brings together 14 partners from 8 eu countries and 1 from uk the consortium comprises 4 leading research organizations 5 leading university groups a supercomputing centre and 3 major aeronautical industries all partners will bring their innovativeness infrastructures and long experience in design and aerodynamics modelling ensuring industrial exploitation of results by exploring new aircraft and engine concepts more effectively 1 sme will bring experience in project management communication and exploitation
biomarker research and evaluation for clinical implementation and supporting systems enhancement

brecise is a publicprivate partnership project cofunded by the innovative health initiative ihi of the european commission aiming at creating a collaborative ecosystem to accelerate the clinical validation of nextgeneration sequencing ngsbased multimodality artificial intelligence ai oncology biomarkers and related technologies by addressing technical and regulatory challenges the consortium unites diverse expertise and resources to validate novel prostate and bladder cancer biomarkers ensuring their efficacy and clinical utility this initiative aligns with the goal of advancing precision medicine in oncology ultimately improving patient outcomes and streamlining personalized cancer carebrecises primary objective is to enhance biomarkerdriven approaches for patient risk stratification disease progression prediction and treatment response assessment within the framework of precision medicine the project addresses the current challenge of limited access to clinically validated prognostic and predictive biomarkers in oncology by providing healthcare professionals with ngsbased multimodality ai oncology biomarkers brecise aims to enable precise disease risk assessment and informed treatment selection contributing to more personalized and effective patient carethe impact of brecise is transformative aiming to revolutionize risk assessment and treatment selection in oncology facilitating the implementation of precision medicine this will significantly reduce unnecessary and ineffective treatments optimizing patient care and minimizing side effects the validated biomarker technologies empower researchers to develop safer and more effective personalized treatments advancing precision medicine these advancements will enhance the competitiveness of european health industries positioning them at the forefront of innovation and healthcare excellence overall brecise is expected to significantly improve patient outcomes enhance healthcare efficiency and bolster the global standing of european health industries
fighting pandemics from below global northsouth public health cooperation in the middle east and north africa 17921942

this project will recapture the lost archives and historical knowledge of international public health cooperation between the global north and the global south by analysing its first and longestlasting instances the sanitary councils in the middle east and north africa mena established in tangier alexandria tunis istanbul and tehran these unprecedented institutions strategised against waves of epidemics and pandemics between the 1790s and the 1940s their european american and native cofounders invented new models for fighting pandemics from below and stopping the diseases in their tracks they continually strove to overcome the familiar barriers to cooperation posed by interimperial competition in a multipolar world economic inequities protests against quarantine restrictions and racial and orientalist biases among others in this light the councils constituted the microcosms of the complex dynamics of northsouth health cooperation that also need to be addressed urgently today however to date there has been no indepth comparative and longitudinal analysis of their workings this project will challenge the mainstream narratives by writing an entangled rather than westcentric history of health cooperation and by shifting the focus from topdown to bottomup processes it will determine what the preconditions for effective international public health cooperation in mena were and hypothesise that rather than great power imposition or veiled imperialism alone multifaceted reciprocal action induced and sustained sanitary internationalism on the ground my preliminary data show that the agency of local actors and smaller and medium european powers in accrediting public health cooperation was more central than has been documented to date this research will test my hypothesis by examining the councils activity performance legitimacy and endurance and by consulting archival sources in europe mena north america and russia
lasers for accelerated netzero transition

approximate 30 of the emissions of evehicles comes from the manufacturing processes due to unoptimised material utilisation low process efficiency product defects and wastecurrent stateoftheart identifies laser material processing technologies the heart of evehicles manufacturing advances in laser technologies and new generation scanning optics in fuel cell and battery manufacturing have the potential to offer enhanced utilisation of materials improved process efficiency and product quality allowing significant reduction in co2 equivalent lasers4netzero will establish an innovative training programme that aims at coaching a new generation of creative entrepreneurial and innovative doctoral candidates phds focused on laser material processing artificial intelligence for quality control advanced process simulation and predictive lifecycle and sustainability analysis for evehicles manufacturing this novel programme will contain both scientific and transferable training activities and will benefit from training across the network eg secondments in total 10 phds will be enrolled developing individual research projects within the project individual phd projects will integrate novel methods and approaches for laser material processing cutting and welding aided by laser beam shaping and ultrafast scanning technologies with the ultimate goal to enhance utilisation of materials improve process efficiency and product quality and reduce defects and waste the consortium involves 6 academic partners and 8 industrial partners guaranteeing that final solutions will be close to the market the close cooperation among multidisciplinary partners will ensure knowledge transfer to cross the valleyofdeath between research and implementation to maximise impact two demonstrators fuel cells and battery systems will be developed in conjunction with the industrial partners
disrupting buddhist circular economies excess and abandonment in contemporary japan

antimaterialism is the most pervasive popular assumption about buddhism that obscures buddhisms material presence and its environmental impacts problematising such moulds this ethnographic project will demonstrate how buddhist materiality drives buddhist circular economies rooted in practices of meritmaking and inherited ritual labour by tracing buddhist objects biographies and illuminating the circular nature of buddhist material exchanges i investigate how things given to local temples generate excess and abandonment practices in contemporary postgrowth japan through histories of these objects and their relations i uncover how demographic hyperageing regional depopulation and changing consumption patterns inform and disrupt buddhist material exchanges how family altars and other personal ritual items as well as meritorious food land and object donations get caught up in discard disposal and reuse cycles and what emotional ethical practical and spiritual implications ensue as such i will illuminate how buddhist practices for processing accumulation and abandonment of buddhist gifts are key to understanding contemporary buddhism and the wider issues of consumption recycling and aspirational nonwaste economies they inhabit i will therefore consider buddhist giving as forces that generate and handle excessabandonment that challenge the viability of the circular economy ideal by producing waste global concern about waste continues to rise this research interrogates the wastemaking impacts of religious activity and assesseses the spiritual and practical implications of managing religious excess in the worlds fastest ageing society it complements and is complemented by the research at the university of copenhagens center for contemporary buddhist studies interrogating buddhist economic entanglements and waste that is created by buddhist economic exchanges thus supporting my development as an expert within this critical field
european recycling and circularity in large composite components

eurecomp aims to provide sustainable methods towards recycling and reuse of composite materials coming from components used in various industries such as aeronautics and wind energy the main pathways to achieve circularity will include i repairing repurposing and redesigning parts from endoflife large scale products and ii recycling and reclamation of the materials used in such parts thus accomplishing reduction of waste and transformation to highadded value products
repurposing of cast systems as nextgeneration tools for genome engineering of mammalian cells

genome editing using rnaguided crisprcas nucleases clustered regularly interspaced short palindromic repeats that associate with crispr associated proteins has radically altered life sciences enabling genome manipulation in living organisms however their use is limited by dependence on dna damage response ddr which restricts genome editing to dividing cells further these nucleases cannot handle dna cargos large enough to harbour regulatory dna circuitry thus precluding genome engineering in intetools i will overcome these limitations by dissecting and repurposing crispr associated transposon cast systems into genome engineering tools casts are naturally occurring prokaryotic proteinrna machineries consisting of an inactive crispr effector complex which associate with tn7 family transposons to insert large dna cargos knowledge of their molecular mechanisms is scarce which prevents their practical application in genome engineering accordingly in objective 1 i will investigate the architecture of different casts to obtain fundamental knowledge of their rnaguided integration i will then use this knowledge in objective 2 to dissect their mechanism underpinnings whereby crisprcas complexes associate with transposition complexes to insert with nucleotide accuracy dna cargos this will inform objective 3 where i will design new cast tools that will allow rnaguided transposition in eukaryotic genomes these revamped casts will be capable of inserting large dnas with high precision harbouring regulatory regions into eukaryotic genomes enabling genome engineering in eukaryotes i will test the redesigned casts in mammalian cell lines and at the organismal level by rescuing the eyeless mutant phenotype in drosophila melanogaster intetools will catalyse a conceptual leap propelling the field into a new era of genome engineering with major biomedical and biotechnological applications especially in synthetic biology
capturing identity change and the long tail in knowledge graphs

at first blush entities and concepts such as dutch east india company or coffee may seem straightforward but in fact they are complex and multifaceted the wealth of digital sources presents the massive potential to study these notions at an unprecedented scale however current technologies for distant reading are not capable of dealing with thistrifecta aims to create a database that describes complex entities and concepts and their contexts by combining language and semantic web technology to extract and relate information from different texts over time in addition a key aim of trifecta is to advance the state of the art in these technologies to deal with change over time and connections to many different narratives sophisticated knowledge representation methods from the semantic web can mitigate the failing that many language technology methods do not incorporate enough background knowledge to recognise and interpret complex entities and concepts in their historical contexts by treating them as rich networks or graphs of knowledge that can express change and relationships to different concepts in space and time semantic databases can handle the complexity needed to make the outputs of language technology tools suited to humanities research via two use cases i identify a set of core contentious entities and concepts in maritime and food history next through a datadriven iterative approach i advance beyond the stateoftheart in natural language technology for the humanities by targeting three key aspects of the recognition and modelling of complex concepts ie identity change and the long tail i propose a novel peerevaluation approach in which a team of humanities scholars computational linguists and semantic web researchers collaborate closely to create truly hybrid artificial intelligence systems that will enable humanities research to scale to big data without losing sight of the contextual complexity
fundamental advances for the fire safety of tall timber structures including the fire decay phase

urban densification sustainability drivers and technological advances foster the development of highrise structures using biobased materials like engineered wood products their main worldwide barrier relates to fire safety although a natural fire has a decay phase structural capacity is traditionally assessed according to a standard fire curve an unrealistic everincreasing thermal exposure with time conceived as worstcase design scenario this results in inadequate assessment for timber often disqualifying it as potential material also the decay phase deemed less onerous due to its lower temperatures is generally omitted from structural calculations however for structural performance it is of crucial importance for timber unlike traditional noncombustible construction materials wood loses its mechanical properties at relatively low temperatures thus the precise interaction between fire and structure needs to be understood because the temperature propagation through the loadbearing timber can unexpectedly lead to structural collapse even after a fire seems extinguished current regulations fail to consider this hazardous issue and available literature on the matter is limited fundamental technical issues still need to be resolved and pertain to the nature of the fire dynamics and the resulting deterioration of the engineered timber mechanical properties in firesafetimber computational models are built to simulate the thermal exposure to structural elements for various fire dynamics conditions eg fuel and compartment characteristics benchscale and fullscale fire tests are conducted on loaded timber structural elements with varying fire decay phase firesafetimber will formulate a novel constitutive model to predict the heat transfer and the structural capacity of timber elements and will develop performancebased methodologies for the firesafe design of timber structural systems that include the effects of the fire decay phase
multicomponent interventions to reducing unhealthy diets and physical inactivity among adolescents in subsaharan africa

the fragile health systems in urban subsaharan africa ssa are already overwhelmed with ncds despite this the implementation of the evidencebased who best buys policies for ncds prevention in the african region has been found to be offtrack additionally less attention has been given to adolescents and yet this is a period in life where behavioural patterns of ncds risk factors are established and track into adulthood there is also a gap in our understanding on how to implement and scale up effective diet and physical activity interventions in real world settings in ssaour project therefore aims to reduce two important modifiable risk factors for ncds unhealthy diets and physical inactivity and their underlying social determinants among adolescents aged 1019 years living in mixed socioeconomic urban communities in two ssa countries ghana kenya by designing deploying and evaluating strategies for implementation of evidenced and theory based interventions mapped on to the who best buys we selected the two countries because they represent different cultural contexts of nutrition transition east and west africa and both countries are undergoing rapid economic development urbanisation and increases in ncd prevalence the intervention delivery will take a multisectoral approach to increasing the capability opportunity and motivation of adolescents to eat healthier and be more physically active we will focus on three settings to enhance the reach secondary schools and familycommunityfaithbased settings and the digital environment using social media together this project will increase opportunities awareness knowledge and health literacy motivate adolescents to increase selfefficacy guide selfregulatory actions and adopt positive health behaviour such as dissuasion from physical inactivity and sedentary behaviours or unhealthy food choices to prevent ncds
multidimensional transition pathway analysis for sustainable futures exploring alternative paradigms and broadening policy options through innovative scenario development

multifutures systematically broadens the scope for policy action towards sustainable societies by assessing and developing transition scenarios based on alternative economic paradigms this involves extending established transition scenarios eg the ecs long term strategic vision scenarios or the ieas net zero scenarios to include alternative economic paradigms that are based on a wide spectrum of sound economic and social theories and have demonstrated potential to address global challenges these paradigms introduce new policy options and instruments which we aim to critically assess regarding their relevance effectiveness and potential tradeoffs the project will proceed through four main steps first we use stateoftheart ai language tools and qualitative methods to map alternative paradigms and develop a paradigm taxonomy second desired futures are extended into quantified transition scenarios using a set of beyond gdp indicators to assess the potential for achieving a climateneutral just and resilient society thirdly stakeholder engagement through anticipatory systems mapping and social simulations will be used to cocreate alternative futures and develop concrete policies that balance tradeoffs mitigate negative impacts and enable dissemination and implementation in addition a largescale survey of 18000 citizens in europe provides insights into public perception and acceptance of alternative paradigms and transition policies fourth stateoftheart modelling will be integrated to assess the economic environmental technological and social impacts of alternative paradigms and policies from a wellbeing perspective including their environmental and social justice implications ultimately multifutures provides policymakers with a comprehensive understanding of alternative paradigms and a broader range of policy options to accelerate progress towards a climateneutral just and resilient society