Dragon09/odtu_chatbot huggingface dataset:
innovative tools for sustainable exploration of marine microbiominnovative tools for sustainable exploration of marine microbiomes towards a circular blue bioeconomy and healthier marine environments

marine microbiomes represent 90 of the total living marine biomass but only a small fraction of them can be cultivated for this reason they are an underexplored source of bioactive compounds carbohydrate polymers and proteins among others sampling the marine biodiversity screening identifying and isolating the relevant microbes is cumbersome expensive and results in a heavy environmental burden low yields high costs and long times to market therefore new approaches are necessary to overcome the limitations for the study of marine microbial communities and their econological use bluetools will unravel the potential of marine microbiomes for healthier oceans and the blue bioeconomy through integration of different fields to develop cuttingedge tools that support fast efficient and sustainable exploration and exploitation of microbiomes avoiding the drawbacks of conventional biodiscovery practices the expected results of bluetools include discovering several hundreds of enzymes rhodopsins resistance genes antimicrobials and antimicrofouling agents thanks to a hybrid workflow of in silico and microfluidicsbased functional discovery resulting in the commercialization 400 enzymes for biocatalysis and 2 new solutions for plasticpolymer degradation increasing the revenue of our industrial partners by 1015bluetools assembles 5 leading european companies 8 academic teams and 1 private rto that have pioneered approaches in functional metagenomics microfluidics microbial ecology and synthetic biology the presence of diverse complementary industrial stakeholders in the consortium from pharma to materials science to sustainability at different stages in the researchtomarket process from rtos to smes to large endusers provides a unique opportunity for broad value creation the planned activities will span 48 months and the project is estimated at ca 9 m with 60 of the total dedicated to creating highlyqualified jobs
the key to precise and accurate cosmology simulating the physics that shapes gaseous haloes

observational programs aimed at mapping the largescale structure of the universe such as erosita and euclid are ushering in the era of precision cosmology our knowledge will soon transition from being limited by statistical errors to being hindered by systematic uncertainties these systematics arise from the theoretical modeling adopted to fit the data and the complex physics of galaxy formation whose effects are often neglected in fact powerful feedback processes from supermassive black holes smbhs affect the phasespace and thermodynamical properties of the gas within haloes and beyond in turn modifying the expectations for the cosmological observables and the largescale matter distribution in order to fulfill the potential of observational cosmology we must take a farreaching step forward by a designing novel types of largescale simulations that model gaseous haloes and the effects of smbh feedback to unprecedented levels of realism and by b providing quantitative and trustworthy that is physicallymotivated and observationallyvalidated prescriptions for cosmological analyses starting from the wellvalidated illustristng hydrodynamical simulations we will extend their scope to more massive systems with a new suite tngcluster we will provide a library of baryoninformed formulae for cosmological constraints with galaxies groups and clusters as well as design novel observational tests for smbh feedback models going beyond the stateoftheart we will develop numerical models that account for the effects of the multiphase structure of the gas of radiation and of more sophisticated smbh physics by using new simulation techniques and by complementing the arepo code with onthefly machine learningbased methods these will enable groundbreaking largescale simulations new types of comparisons to observations of both the hot and cold halo gas and ultimately novel and independent analyses of available cosmological data
unlocking the supply of rare earth elements in europe through responsible sustainable and decarbonised innovative technologies

responsible sustainable and low co2 footprint mineral extraction is vital for the preservation of our planet ensuring responsible supply of minerals involves addressing the environmental social and economic impacts of mineral extraction and developing technologies and knowhow to minimize them mining within these lowimpact boundaries in a world that is putting an increasing pressure on the mineral supply requires developing environmentally friendly safe intelligent and resource efficient extraction technologies and methods reesource will set a sustainable and decarbonized value chain basis for the extraction of rare earth elements rees in europe supporting the ambition of the continent to become selfsufficient on rees this target will be achieved through a set of actions scientific technical social and financial that will serve to pave the road for the development of the european mining of the future these include i enhancing key technologies of raise mining to foster invisible mining with minimal socioenvironmental impact and lower co2 emissions footprint compared to existing approaches ii developing novel formulations based on environmentally friendly chemicals for both the mineral beneficiation process of rees and the process water treatment supporting the recirculation of this resource iii developing a novel stabilization technique for tailings making them suitable for backfilling stabilizing the mine and avoiding the need of tailing ponds iv valorize the tailings through a circular economy approach to make them suitable for expanded value chains as geopolymers for construction applications and composite materials for catalytic and co2 capture applications v assess the social dimension to maximize early social awareness engagement and acceptance and vi multiply the project impact through crossfertilization with other projects and clusters supporting the mass adoption of unfc and unrms in the raw materials sector
membrane electrode assembly for the high pressure electrochemical conversion of co2 to c2h4

the electrochemical conversion of co2 to chemical fuels is a promising technology for recycling co2 and closing the carbon cycle amon the different products of the electrochemical reduction of co2 multicarbon c2 product are more desirable because of their high energy density and high market price among them ethylene is widely used for the production of raw materials and has a market price around 1000tons which suggests relatively low threshold towards profitability the development of such a technology to convert co2 to c2h4 is however limited by the lack of selectivity and efficient catalysts to drive the reaction while co2 mass transportation to the active sites limits the conversion rate during the course of our ercstg 2d4co2 we have developed cubased electrocatalysts modified with aromatic functions which demonstrated strongly improved selectivity for ethylene at industry relevant current density of 300 ma cm2 the aim of the hipceo2 project is to apply the novel cubased catalyst develop in our group in a highpressure membrane electrode assembly electrolyzer our specific goals are to realize a prototype with electrode size of 100 cm2 and verified stability of 1000 hours that will be used as a demonstrator to reach out potentials endusers and future partners
technological choices of coastal populations a functional perspective through the usewear study of knapped lithic tools during the late mesolithic 63004500 cal bc in south norway

techcoast aims to understand how past populations have used tools and what technological choices they have made to deal with the coastal environment on the southern norway seashore the late mesolithic 63004500 cal bc sites constitute a unique knowledge repository of coastal huntergatherer populations in which stoneknapped tools are the most frequent artifacts however very little is known about the use of these to exploit coastal resources how and for what were these tools used how does their use reflect socially transmitted technological knowledge to exploit coastal resources through an innovative and interdisciplinary technofunctional approach techcoast aims to bring new functional data on the use of lithic tools to further understand the technological choices of coastal populations analyses of the plastic deformations on the surface of the tools due to their use ie usewears will be performed on three preselected lithic assemblages in addition an experimental analytical program will be set to identify quantifiable wear attributes in lithic tools resulting from the exploitation of marine animal resources by means of confocal scanning microscopy finally by combining observations with a dynamic technological approach and landscape archaeology the project will aim to identify the technological choices of the coastal groups more widely the present project will provide a broader perspective on the atlantic european seashore allowing crossregional comparisons with other coastal groups the techcoast project results will have an important impact on the research of the coastal stone age huntergatherer populations as well as bring new methodological perspectives to usewear studies the results will be disseminated by openaccess publications and outreach activities through a prehistoric perspective the project aims to engage in the social debate about the role of technology in the exploitation of environmental resources in the present
strongfield electrodynamics in flying focus pulses

in this action we propose a theoretical investigation of charged particle behavior in external laser fields using the recentlydescribed flying focus ff regime a laser field setup which allows precise control of the position and velocity of its focus this novel regime makes it possible to adjust the laser focus so that it copropagates with the particle including the situation when the particle is moving against the laser phase fronts the resulting long laserparticle interaction time enabled by ff pulses is expected to significantly enhance radiation reaction methods of particle beam control and cumulative magnetic moment effects along the particle trajectories in the classical relativistic framework this will give us the possibility to test the equations of motion which include radiationreaction terms and sterngerlach force in the case of particles with spin in the quantum framework we will first investigate analytically the probability of single photon emission by a high energy electron in a flying focus beam and then study numerically the cascade emission of several photons quantum radiation reaction finally we will implement flying focus fields and the calculated probabilities of the quantum emission processes into the particleincell code smilei with this code we will perform simulations of experimental setups exploiting flying focus fields in laserparticle interactions thus we will identify viable experiments that could lead for the first time to unambiguous radiation reaction detection allow for methods of particle beam control and enable us to probe quantum electrodynamics in the strong field regime
stable inorganic tandem solar cell with superior device efficiency and increased durability

to face the grand challenge of transforming the energy system to include at least 42 photovoltaic energy in 2050 as forecasted in a scenario by irena our proposed project sita aims to explore innovative concepts for tandem solar cells based on two technologies with strong competence base in europe silicon heterojunction shj and high bandgap cuingases2 cigs a novel tandem concept with a 2terminal 2t approach requiring no additional cables or electronics will be developed enabled by recent and further development in wide gap cigs devices leading to high efficiency 18 sita will demonstrate the durability of the new modules under realistic outdoor conditions delivering the next generation of stable inorganic tandem solar modules with superior device efficiency 30 sitas technology will build on and increase the efficiency of shj modules by a factor of 15 with marginal increase in the use of the costliest raw materials this in turn leads to a considerable reduction in area related system costs of up to 25 per installed power and a corresponding reduction in the levelized cost of electricity lcoe tandemjunction efficiencies have recently approached or even surpassed the singlejunction shockleyqueisser limit for prototype devices sita will address the remaining limitations in terms of stability scaling and manufacturing costs as well as environmental impact
systems methods context

symeco systems methods context proposes a transformative agenda one that is cognisant of the changing landscape of software development while seeking to shape it the key research strands explore what we build systems how we build these systems methods for the world we want context the 60month research training programme will fund 16 postdoctoral fellowships at lero and will incorporate international mobility intersectoral exposure and interdisciplinarity lero is irelands research centre for software headquartered at the university of limerick ul beneficiary with partners in other irish universities and institutes of technology the implementing partners will be university college cork university college dublin dublin city university national university of galway and trinity college dublin the ten associated partners are drawn from leros extensive industry network and comprise a mixture of multinational corporations and smes the programme aims to attract researchers from the fields of computer science software engineering information systems humancomputer interaction and business management during their 2year fellowship fellows will receive disciplinespecific skills training to assist career development and will be provided with a comprehensive set of courses to improve their transferrable skills to diversify their employment options fellows will also avail of a 4day summer school incorporating the themes of systems methods context with one day dedicated to industry entrepreneurship trained fellows will be attractive to industry the public sector or academia the symeco research training programme will produce the next generation of european leaders in software development that will have the skills to help in shaping europes digital future and contribute to the newly launched european declaration on digital rights and principles this proposal seeks 152 million ec funding to match lero cofunding of 138 million
understanding the genetic encoding of dynamic interactions underlying transcriptional regulation

transcription factors often serve as key hubs for dynamic proteinprotein interactions in eukaryotic cells aside from their characteristic dna binding domains the vast majority of transcription factors contain activation domains that are often intrinsically disordered these domains are not wellcharacterized but are thought to contain key sequencedistributed features that enable transcription factors to interact with their many binding partners and have recently been associated with the capacity to form transcriptional condensates through phase separation many questions remain about how genotype and phenotype are related in these relatively uncharacterized regions particularly with respect to their dynamic binding interactions with important implications for human diseaseassociated mutations here we propose to help uncover the relationships between sequence structure and dynamics of these interactions in vivo using the power of deep mutational scanning and protein complementation assays in budding yeast
complex fluids in fractured geological media for enhanced heat transfer

geoneat aims at unraveling the potential of engineered shearthinning st fluids in enhanced geothermal systems to improve heat recovery efficiency and in heat tracer tests to infer structural parameters of deep hot reservoirs cuttingedge interdisciplinary methodologies from applied mathematics and hydrology are merged in a novel framework to achieve two scientific objectives 1 characterizing quantitatively how using engineered fluids impacts coupled flow and heat transfers in fractured media at all scales 2 inferring structural information on fractured media from coupling inverse modeling to field measurements of the heat exchange using complex fluids of different rheologies to this aim two technical challenges will be tackled 1 the development of a multiscale model of coupled flow and heat transport in fractured geological formations 2 the obtention of experimental data in a synthetic analog medium to validate the model and constrain an inverse model for characterizing the mediums geometry geoneat relies on the expertise of a topnotch consortium consisting of the university of bologna beneficiary supervisor prof vittorio di federico and cosupervisor prof valentina ciriello experts in subsurface stochastic modeling stanford university outgoing phase supervisor prof daniel m tartakovsky and cosupervisor prof roland horne experts in uncertainty quantification inverse modeling and geothermal energy and the university rennes 1 secondment supervisor prof yves mheust and cosupervisor dr maria klepikova experts in subsurface heat transfers and analog experiments of flow and transport dr lenci will receive excellent training in the three institutions to pursue outstanding research propelling his career development towards becoming a tenured researcher in eu academia geoneat will contribute to promoting the growth of a lowcarbon sustainable renewable energy market consistent with the eus green goals and priorities
hyperpolarized nmr made simple

nuclear magnetic resonance nmr is one of the most powerful analytical techniques currently available with applications ranging from synthetic chemistry to clinical diagnosis despite the progress in developing new systems applications are often limited by the low sensitivity of nmr hyperpolarization techniques have the potential to overcome this limitation and revolutionize the use of compact nmr however the stateofart devices for hyperpolarization are limited by either the need for cryogenic cooling long setup and polarization times with the risk of experimental failure costly systems cumbersome equipment and a limited range of polarizable moleculesmagsense project significantly simplifies the existing hyperpolarized nmr paradigm our unique approach is to produce spin order in standard hydrogen molecules to act as polarization batteries the nmr sample with the enhanced target molecules is placed in a standard nmr spectrometer for ultrasensitive analysis no modifications are required to the customers existing nmr instrumentation magsense provides significant advantages in signal enhancement and measurement times enabling the analysis of intermediate steps in the chemical reactionmagsense will provide many new opportunities for the fields of synthetic chemistry analytical chemistry and nmr research it will be a marketcreating innovation with pointofservice applications such as diagnosis in icu unitsthe project will create opportunities for young researchers in the nmr field through our engagement with universities and technology institutes at the same time interested industry players have shown their support for the projectnvision is backed by leading deeptech vc funds from the us and europe and currently employs more than 25 physicists engineers and material scientists including professionals with more than 10 years of experience in nmr research technology development and project management
recreating molecular memories imaging the mechanics of chromosome assembly and the birth of cell identity

the gene expression patterns that define specific cell types are determined in part by epigenetic information encoded in histone marks that guide chromatin organization during chromosome duplication new histones lacking this information must be deposited to support the doubling of chromatin however the molecular mechanism of histone deposition and the coordination pathways that ensure epigenetic information is transmitted remain unknown determining the mechanics of chromosome assembly promises to open a new frontier in our understanding of the propagation of cell fate decisions that support multicellular life due to the antiparallel configuration of dna different dna synthesis mechanisms are used on the daughter strands during dna replication how this is coordinated with the symmetric duplication of chromatin organization on daughter chromosomes is not known i hypothesize that the replisome contains an extensive network of molecular wiring encoding the fundamental logic that governs histone transfer and deposition that is essential for the preservation of epigenetic cell identity and chromosome integrity to discover this network i propose a research program combining structural biochemical and singlemolecule imaging approaches to gain access to critical missing information we will develop techniques that reveal the dynamics of histone transfer and deposition independently on each daughter strand in realtime for single replisomesthe proposed research will determine the structural basis of new histone deposition reveal the dynamics of replicationcoupled chromatin assembly and address how epigenetic states are reestablished on daughter chromosomes realizing these objectives will represent a major breakthrough in our understanding of the molecular mechanics of chromosome assembly the transmission of epigenetic cell memory and allow for transformative biomedical technologies through engineered reprogramming of epigenetic memories
explaining human decisionmaking by combining choice and process data

decisionmaking is a core element of human activity and the decisions we make can have significant consequences for ourselves others and the world we live in thus the ability to explain and predict decisionmaking is vital for improving individual and societal outcomes especially when addressing global challenges like climate change sustainable energy ageing populations and public health mathematical models of decisionmaking can help us to understand and predict human behaviourdespite significant progress several scientific challenges persist in the applicability of advanced behavioural models to realworld problems many models focus on predicting decision outcomes rather than explaining the decision process itself information contained in neurophysiological process data that emerge during decisionmaking are often ignored and methods for collecting behavioural data fail to create realistic impressions of scenarios representing the futureimmersion aims to advance the study of human decisionmaking by developing new innovative methods for combining choice and process data this includes new models for integrating choice and process data new statistical inference procedures tailored to such models and new methods for collecting rich behavioural data in immersive experiments the proposed research will create a paradigm shift in behavioural research with impacts on many application domains immersion will equip researchers with a new powerful toolkit for extracting deep behavioural insights from rich data using advanced modelsthe proposed research includes substantial empirical work applying immersions methodological innovations to realworld problems with implications for the humancentric design of future transport systems this work includes case studies to explain and predict human decisionmaking in the contexts of transportation infrastructure development pedestrianautonomous vehicle interactions and pedestrian wayfinding