Dragon09/odtu_chatbot huggingface dataset:
harnessing novel micropeptides in cardiomyocytes to promote cardiac regeneration

despite advances in clinical care heart failure consequent to myocardial infarction remains a leading cause of mortality worldwide absence of cardiac regeneration postinfarction is mostly explained by the reduced mitotic potential of adult cardiomyocytes that in comparison with their embryonic counterparts have an accumulation of morphological metabolic and biochemical adaptations that render them recalcitrant to proliferation devising tools to precisely control the maturational status of cardiomyocytes would enable novel therapies for cardiac regeneration either by stimulating cell cycle reentry of preexisting cardiomyocytes or enhancing the maturational status of cardiomyocytes derived from induced pluripotent stem cells for cell therapy novelcare will explore the therapeutic potential of micropeptides a novel class of proteins that despite their small size can play major cellular roles based on extensive preliminary work i propose an ambitious interdisciplinary research program bridging advanced omics animal models human samples bioinformatics cellular phenotyping and innovative strategies for gene therapy we will apply new translatomics and proteomics approaches to identify micropeptides conserved across species and modulated during cardiomyocyte maturation define their cellular functions and test their potential to induce proliferation of cell cycle withdrawn cardiomyocytes or enhance maturation of stem cellderived cardiomyocytes in a highrisk highgain part of the project we will develop a novel approach for gene therapy enabling timecontrolled cardiomyocytespecific expression of a combination of micropeptides normally expressed by embryonic cardiomyocytes and assess if this strategy successfully promotes regeneration of the adult heart postinjury in conclusion novelcare will generate new resources technology and knowledge pushing beyond the stateoftheart in the fields of molecular cardiology and cardiac regeneration
using thermal limits to understand community response to climate warming

when will communities reach their upper thermal limits ie their climate countdown a key challenge for ecology and conservation only to be addressed by understanding the biological processes driving community thermal limits and assessing how fast warming actually pushes communities to these limits and thus increases their vulnerability the difference between upper thermal limit and habitat temperature is widely used to predict thermal vulnerability yet existing models are mostly limited to single species and neglect key processes such as species interactions to predict the thermal vulnerability of multitrophic communities we need to scale up thermal limits from species to community this can only be done by answering four key questions i how do species interactions impact individual thermal limits ii how do acclimation and evolution influence community thermal limits iii how do temperature impacts on food web structure and community composition influence community thermal limits iv how does spatial heterogeneity in warming rates affect communitys vulnerability to address these four key research questions i propose a novel integrative approach combining seminatural aquatic experiments temperaturedependent community models analyses of 200 lake food webs and climatic projections this ambitious research programme will evaluate how the evolutionary dynamics of each species their interactions and food web structure collectively contribute to defining community thermal limits it will predict the climate countdown of lake communities and test if the latter informs of biodiversity losses induced by climate warmingthis project will provide unprecedented insights on community thermal vulnerability by linking ecophysiology with community ecology by uncovering the mechanisms of community thermal limits it will contribute to understanding how communities respond to climate change and provide a new means of predicting the future of biodiversity
resilient oats improving drought stress resistance in a changing climate

providing food security in the face of climate change and increasingly frequent extreme heat and drought events is one of the greatest global challenges drought is the most influential environmental factor limiting crop yields for a growing world population and leading to significant economic losses to safeguard agricultural production it is crucial to develop highyielding crops with improved water use efficiency oat avena sativa l is an emerging crop that offers significant benefits for human health and provides a nutrientrich plantbased protein source with a low carbon footprint however oats are sensitive to drought and progress in breeding droughtresistant varieties while urgently needed is limited the oat genome is characterised by its enormous size high repeat content and complex polyploid structure therefore efforts to investigate complex agricultural traits such as drought stress resistance have long been hampered by the lack of genomics resources recently a fully annotated reference genome sequence of avena sativa became available to which i contributed significantly representing a fundamental breakthrough resist will take on the challenging highpriority task of deciphering the molecular basis of drought stress resistance in oat providing substantial solutions to secure yields of this emerging healthy and versatile crop to this end resist will exploit innovations in plant genomics and in particular oat genetics employ cuttingedge highthroughput phenotyping methods and establish gene editing protocols that provide an innovative basis for accelerated and targeted breeding of oats resist provides the indispensable foundation for the development of betterperforming oat varieties under drought conditions to secure oat yields as a sustainable source of a highly nutritious healthy proteinrich plantbased diet for billions of people
ip discoverability and partnerships reviving the international promotion of european values through european animation industry ecosystem

the overarching goal of anima mundi is to awaken the sleeping giant of animation as a popular promising and potent sector of the ccis in european diversity and artistic expression global markets and international cultural relations anima mundi will do so by generating and assessing data on and addressing crosssectoral strengths as well as pervasive gaps in terms of intellectual property ip discoverability and international partnerships in the european animation industry ecosystem eaie that enable or hinder its international promotion specifically anima mundi will i provide an interdisciplinary mapping and assessment of the ways in which it is possible to increase the visibility of and access to european animation internationally ii pilot the transformative impact of european animation to promote eu priorities culture and fundamental values abroad by investigating practices and innovative hubs of creativity with a special focus on children and youth and iii cotest the potential of european animation to strengthen cooperation among stakeholders involved in the ccis and to establish strategic alliances with other sectors to achieve this anima mundi a multistakeholder team of five academics and eight key stakeholders develops among other things i a european animation brand to support the visibility of the eaie globally ii organises joint promotional activities on european coproductions at the annecy international festival iii develops an anima mundi dashboard a tool for policymakers and professionals when assessing the visibility of and access to european animation internationally iv pilots the design of a tool promoting discoverability through gamification v delivers empowering partnerships and ip toolkits to promote effectively eu priorities abroad and vi develops a firstaid kit handbook on audiences including youth and children to support the promotion of eaie abroad in a bottomup and imaginative manner
development of a pointofcare microfluidic device for therapeutic drug monitoring in cancer treatment poctdm

cancer claims almost 10 million lives annually making it one of the major causes of death around the world despite the development of novel drugs and treatment options the 5years survival of the most common cancers are still strikingly low chemotherapy ct is a widely used option to treat malignancies however ct protocols are established on a one size fits all basis and ignore interpatient differences in drug pharmacokinetics which influence the blood levels of anticancer drugs therefore leading to improper dosing in 50 of patients missing target blood concentration will lead to drug resistance andor unwanted side effects therapeutic drug monitoring tdm could be the key to improve and personalize ct however the lack of an affordable pointofcare poc method is preventing its introduction to oncology mass spectrometry ms is the golden standard analytical approach to determine blood drug levels but the instrument and specialized expertise to operate it are rarely available in the clinical environment the high volume of blood required for ms analysis is also a challenge because cancer patients are regularly weakened exploiting the strong and specific fluorescence of anthracyclines the most used ct agents we propose a radically new microfluidic chipbased approach to rapidly determine plasma concentrations of several widely applied anticancer drugs microvolume plasma separation and collection from a drop of blood 50 ul will be done with a specifically designed chip then plasma anthracycline concentration will be measured using a compatible spectrophotometer the approach will be validated using clinically relevant mouse tumour models and with samples from veterinary cancer patients this interdisciplinary project combining microfluidic engineering with cancer research will introduce a novel poctdm system which could change ct treatments and improve survival through patienttailored therapy
high performance safe secure opensource leveraged riscv domainspecific ecosystems

the isolde project aims to significantly support the digital transformation of all economic and societal sectors to speed up the transition towards a green climate neutral and digital europe to strengthen the design capacity and to achieving digital autonomy eu wide by the end of our project we will have high performance riscv processing systems and platforms at least at trl 7 for the vast majority of building blocks demonstrated for key european application domains such as automotive space and iot with the expectation that two years after completion isoldes high performance components will be used in industrial quality products to achieve such an ambitious goal an industrialgrade opensource support for development verification and maintenance will be provided the customizable ips will be hosted on physically located european servers to address the european digital sovereignty requirement that the isolde project will support this way isolde will have delivered a major contribution to the unification and focus of the fullfledged industrysupported ecosystem for riscv opensource architecture especially in the area of embedded highperformance computing and thus to the creation of a breakthrough design capacity across the eu microelectronics industry
a new ccu composite structure with a novel demountable connection towards co2 sequestration and material recyclability

carbon capture and utilization ccu is receiving increasing interest due to the continuously increasing co2 emission where one pathway is to mineralize carbon in concrete building material compared with portland cement reactive magnesia cement rmc has the potential advantage of higher co2 sequestration during early age curing and its service life still the inadequate carbonation depth limits its application another approach to reducing carbon emissions is recycling and reusing components in construction the key to realizing component reuse and concrete material recycling is the proper demountable connection however the sudden slippage and laborconsuming problems of bolts were reported and might hinder the popularity of reusable structurestherefore this project will introduce hollow natural fibers hnfs with large lumens to enhance co2 penetration and overcome the carbonation depth limitation the participants will codevelop a mix design of hnfreinforced rmcbased concrete that achieves a compressive strength of 50 mpa and a oneway carbonation depth of 60 mm besides a novel demountable boltwedge system for dowelbased connectors will be proposed to realize excellent mechanical behavior and efficient construction of ccu composite structures the shear behavior of the demountable connectors with the boltwedge system will be investigated by conducting pushout tests and finite element modellingfor the scientific community the mix design will provide a solution for ccu structures and the boltwedge system may initiate new research on prefabricated and reusable structures regarding societal and economic impacts the proposed ccu composite structure could reduce emissions by co2 sequestration and lower the net costs of reducing emissions due to the enormous scale of infrastructure reusing structural elements after their first design can decrease construction time and material costs this project is in line with the european green deal goals
mixed reality environment for immersive experience of art and culture

engagement with the art and music can have a range of positive effects on physical and mental health however access to the many benefits of musical experience can be limited due to various reasons 1 the geographic location of the venue 2 personal limitations in access 3 limitation on the schedule of the concerts and performances 4 cost of the experience due to these limitations the effort and cost of getting access to the concerts and performances override additional value the participant would get from the experiences in xtreme project we remove these limitations by developing a humancentered mixed reality mr solution that instead of requiring the participant to be physically present in the venue brings the concerts and performances to a remote location via mr technology while retaining the immersive experience and even giving additional dimensions to it by integrating real and virtual contents our solution also allows for virtually shared realistic experience together with selected social circles of the user the solution removes geographic limitations as by the mr solution the concerts and performances can be accessed virtually from anywhere and they hence are more inclusive for people with limited access likewise providing a global access to the art and music provides a wider audience for musicians and artists not limiting the number of seats by the size of the physical venue as this solution removes the necessity to travel to concerts and performances it also provides a greener alternative in contrast to the current stateoftheart our solution targets at making an mr solution to the concerts and performances where those are in in 3d both for visuals and sound blended into the room of the users we will also provide maximised experience of presence via reconstruction of the users and their behaviour in the shared access and enhance the immersion by providing an additional visual layer to the sound
drilled extreme events from the past unravelling a longterm history of giant earthquakes and tsunamis for geohazards assessment

the study of giant earthquakes and tsunamis is essential in modern hazards assessment however these natural disasters have a long recurrence time and instrumental as historical records are inadequate to reduce uncertainties in hazards predictions submarine paleoseismology is a novel approach that combines sedimentology and marine geology to identify describe and date earthquake deposits its strength relies on covering much longer periods than instrumental or historical catalogues recent technological advances have allowed to correlate homogeniteturbidite deposits hmtu with seismic and tsunami events along the japan trench the oceanographic cruise iodp 386 drilled and cored the deepest hmtu records in the scientific ocean drilling historydeep will use these unique seismic and tsunami sediment archives to 1estimate their longterm recurrence time 2 reduce epistemic uncertainties in hazards assessment and 3 provide the most complete onandoffshore catalogue of giant events over several thousands of years i will develop tools to unravel prehistorical events using an innovative multiproxy approach using microxray computed tomography xct images physical and geochemical properties along with marine geophysical datasets and chronostratigraphic correlations integration with onshore records will produce the first database of its kind for japan and other highrisk areas worldwide improving knowledge on seismic cycles and reducing the data uncertainties used by scientists and decisionmakers the governments need these crucial tools to take the necessary measures to protect their population and infrastructures deep will result in a clear threewaytransfer of complementary skills in between myself deepmarine sedimentary processes the host institution geological hazards assessment and the partner institution submarine paleoseismology i will develop new skills in microxct computational merging earthquake modelling and geohazards assessment
first closedloop noninvasive seizure prevention system

the goal of project relieve is to build the very first noninvasive effective closedloop monitoring and intervention system for brainrelated disorders the outcomes can be used to treat or manage various psychiatric and neurological disorders we do this by pushing the technological boundaries in two separate domains 1 ai domain we develop a class of mathematical and algorithmic tools for brain data based on the recently developed mathematical theories that are potentially useful for the realtime monitoring of the brain data such advancements have shown promise in robotics and selfdriving cars and have high potential to work efficiently in highly dynamic environments where personalization and low computation power is a must this makes such algorithms runnable using brain data such as eeg electric activity on the head surface on ordinary wearable devices 2 neurostimulation domain we combine two characteristics of the ultrasound waves in stimulation and imaging of the nervous system to build the first smartnavigated wearable ultrasound patch we also choose the vagus nerve as the target for neurostimulation as one of the most promising sites to interact with the nervous system with proven implications for a large spectrum of neurological and psychiatric disorders eg dementia depression epilepsy etc we call this unit wuvns standing for noninvasive wearable ultrasound vagus nerve stimulationin the next three years we will use epilepsy as the first use case of the developed technologies to train and test a closedloop system for this the ai monitors the brain through a patch that records eeg in addition to other physiological measures such as heart rate and motion upon prediction of a forthcoming anomaly seizure in this case by the ai unit the neurostimulation module activates and stimulates the vagus nerve noninvasively during this process also a socalled active learning happens in which the ai learns from the reactions of the nervous system to the stimulation protocol and can finetune the protocol for future interventionsto achieve this we have designed a complex phasebased development and testing plan the first two generations gen 1 and 2 are the intermediate versions of the full system and act in open loops validating each of the ai and neurostimulation subsystems these two generations already have high potentials to independently turn into medical device products with large market needs ultimately in gen 3 we close the loop by integrating the ai and the wuvns and consequently validate the efficacy and the usability of the system
diabetes obesity and the kidney

chronic kidney disease is a major cause of morbidity and mortality in the eu about 1015 of the eu population has chronic kidney disease ckd and this number is expected to increase in the future decades diabetes is today the main cause of ckd in the eu about 30 of the cases with dialysis treatment in the eu have diabetes also we are facing a pandemic of overweight and obesity in the eu overweight and obesity are increasing at a rapid rate in most of the eu member states with estimates indicating that of 527 of the adult aged 18 and over eus population had overweight of relevance obese patients with metabolic syndrome are at risk for developing renal disease understanding this topic may help preventing renal disease and offering a better treatment to renal patients the study of the renal consequences of diabetes and obesity is a major goal of the chronic renal diseases research group of instituto de tecnologas biomdicas university of la laguna a research centre created 10 years ago in canarias island an outermost region of the eu the group has experience in clinical and basic research in this particular area of knowledge with previous studies in basic and clinical research in obesity diabetes and renal disease however to advance in our research and become a reference leader in this field we need to increase our research capability as well as our visibility and networking for it we contacted with our partners two leading institutions in denmark and norway to help us in giving that step ahead and become a reference leader in this field we foresee to grow to a sustainable structure that will allow us to increaser our research capability participate and coordinate he proposals besides improving our relation with pharma industry and pave the way for the creation of a renal function laboratory that will foster our research in the field as well providing services other researchers groups and the pharma industry in eu
advanced ai and robotics for autonomous task performance

maintaining the competitiveness and leadership position of crucial industries such as renewable energy and agriculture is contingent upon ai and robotics increasingly becoming a widespread and integral part of the relevant technological landscapes particularly in the face of steep labour shortages arise project aims to introduce a combination of perception and control modules around a reconfigurable robotic manipulator that will enable a step change in the level of automation of complex manipulation tasks arise will comprise the following key novel technology components that will significantly push the state of the art in terms of automatic task segmentation human robot interaction and complex manipulation 1 two reconfigurable pneumaticbased robotic manipulators mounted on a mobile robotic platform 2 novel soft endeffectors with variable stiffness that will allow for a diverse set of manipulation tasks 3 a robotic perception module comprising 3d vision algorithms 4 a localisation and mapping module that will allow the robot to accurately identify its position within the environment 5 a semantic mapping module powered by scene understanding algorithms 6 a knowledge representation framework that will capture important information regarding objects properties and relationships 7 a hierarchical imitation learning framework for acquiring robotic skills to accomplish complex tasks directly from human demonstrators 8 a humaninteraction conditioned path and task planning module enabling reactive robot control 9 an edgeai framework for deploying machine learning models and computer vision algorithms at the edge in a streamlined fashion the arise toolchain will be integrated and validated in 5 real use case scenarios including installation and repair and transplanting and harvesting tasks in solar and hydroponic farms respectively