Dragon09/odtu_chatbot huggingface dataset:
economic and social considerations for the future of nuclear energy in society

using a deliberative approach ecosens will analyse citizens views and risk perceptions benefits and potentials of current and new nuclear technologies in the context of major societal challenges climate crisis sustainable energy policies energy security it will review through a socioethical lens the uptake of recommendations on stakeholder engagement and transdisciplinarity notably integration of social sciences and humanities in nuclear research and decision making developing recommendations to overcome challenges societal stakeholders authorities industry academia and civil society are engaged to explore and coconstruct possible energy futures and the role of nuclear energy thereinsustainability assessment of current nuclear energy technologies will take into account the entire life of the nuclear investment including the nuclear fuel cycle integration of new technologies gen iii iv smr is then explored in the context of the future energy market and societal developments to identify the possible roles of nuclear energy in the climate neutral economy targeted for 2050 multiple perspectives nuclear experts social scientist stakeholder society are integrated and methodological recommendations for sustainability assessment are agreedto address the weaknesses of existing economic models ecosens develops a novel model based on the system of provision approach in order to create and calculate indicators relevant for a plethora of stakeholders consumers governments suppliers the model will include the social discount rate and considers the limits of our planet as reflected in the circular economy system a series of national case studies evaluates the model and provides relevant recommendations to stakeholdersecosens activities and results will be largely communicated and disseminated through the network of stakeholders established to support innovative involvement as well as through open access facilities
the transcriptional regulation of cardiomyocyte polyploidization and its relevance in cardiac regeneration

the mammalian heart is a nonregenerative organ due to the extremely limited ability of fully differentiated cardiomyocytes cms to proliferate while neonatal hearts still contain mostly diploid cms and regenerate efficiently physiological postnatal cm polyploidizationhypertrophy ensures the contractile capacity of the adult myocardium but represents a roadblock to cardiac regeneration due to this limitation diseases that provoke cm loss like acute ischemia frequently lead to heart failure reactiva will establish a new strategy for heart regeneration based on the reactivation of a dormant endogenous mechanism thereby achieving unprecedented advances in the field of cardiac regenerative biology in mice the proportion of adult diploid cms adcs correlates with regenerative ability however efforts to identify a molecular signature for adcs have been unsuccessful which has precluded exploring their roles in heart regeneration using an improved methodology for singlecm rnaseq my group has identified a molecular signature of adcs related to the fetal program and controlled by a single repressor transcription factor this factor is specifically expressed in the polyploid cm population pcm and its inhibition in the postnatal mouse heart robustly increases adc abundance and proliferative activity based on these findings we propose that adcs underlie a vestigial endogenous mechanism for adult mammalian heart renewal and that their stimulation will promote heart regeneration reactiva will exploit our new findings on adcs to 1 fully characterize the adc regulatory network identifying factors to modulate it 2 identify and trace adcs in the adult heart defining their niches and contribution to renew and expand the cm population during heart homeostasis aging and disease 3 use the generated knowledge to induce adc activation with the goal of promoting adult mammalian heart regeneration
chemical reactions as causes and laws

creacal will realise an unprecedented study of chemical reactions from the perspective of causation and lawhood with the aim to establish a rigorous framework for the philosophical investigation of chemical reactions chemical reactions are fundamental to science and engineering as they identify the causes of the transformation of a specific set of chemical substances while at the same time representing lawlike generalisations about transformations of types of chemical substances however philosophers have neglected chemical reactions they have not examined them either with respect to causation or with lawhood this is a clear lacuna in the philosophical literature given that reactions are the main means with which scientists explain chemical transformation creacal will synthesise these two fields to offer an account of laws and causation that not only does justice to the rich yet underexplored knowledge of reactions but that also deepens our understanding of causation and laws themselves creacals results will contribute to science by illuminating the intricate features of chemical reactions that are revealed by viewing them as causes and laws moreover it will fill a significant gap in philosophy by introducing a new case study for the investigation of causation and lawhood while also achieving genuine progress in philosophy of chemistry that will further consolidate the latter as an important field within philosophy
jwst breakthrough in galaxy formation mass buildup efficiency at cosmic dawn

we present sfeer star formation efficiency in the epoch of reionization an ambitious project to enable one of the most significant and longlasting leaps in our understanding of early galaxy formation the discovery of exceptionally massive galaxies in the distant universe has confronted us with puzzling questions about how galaxies could assemble so efficiently at early cosmic times unfortunately significant instrumental limitations have prevented us from robustly reconstructing their physical properties the recent launch of the james webb space telescope jwst has ignited a revolution its exquisite sensitivity and spatial resolution are going to provide dramatically new information on massive galaxies in the the epoch of reionization eor and beyond sfeer is set to play a dominant role in this process at its core is a cycle 1 jwstnirspec program i am leading which will obtain spatially resolved spectroscopy for 12 exceptionally bright galaxies in the eor remarkably estimates of the interstellar medium ism reservoirs of this sample are already in our hands thanks to recent atacama large millimeter array alma observations providing information on their molecular gas and dust content and the fraction of obscured star formation this joint dataset clearly stands out in the panorama of current jwst programs and constitutes an important benchmark sfeer will enable to probe the assembly history of these tantalizing objects through the characterization of their ages stellar mass energybalanced starformation rates metallicity merging fractions and gas kinematics and their relationship with the host dark matter halos taking advantage of complementary jwst programs and widearea multiwavelength data from ground and euclid we will extend our results to higher and lower masses and probe galaxy formation from the earliest points in cosmic time
personalized disease prediction and prevention in chronic inflammatory disorders

background chronic inflammatory diseases cid are a group of noncommunicable disorders of the immune system with a lifetime prevalence of over 10 in the eu rheumatoid arthritis ra and inflammatory bowel diseases ibd are two archetypal cids with a particularly high unmet medical need and impact on european health care systems objectives the perprevcid consortium aims to set up new standards for decision support tool development for preventive and early therapeutic interventions in ra and ibd selected main aims are i to define actionable predictors from longitudinal multilevel omics and clinical data integration in ra and ibd we will identify markers indicating progression from presymptomatic to manifest disease and signatures predicting early disease relapse ii to develop new tools for homebased and continuous assessment of patientrelated data dimensions using digital health appswearables including more innovative objective parameters such as movement patterns physical activity and sleep iii to assess the healthpromoting effects of interfering with the tryptophan pathway in a proofofconcept nutritional study in early ra and ibd iv to study ethical legal and economic consequences of risk assessment and early lowthreshold preventive interventions important aspects are the communication of the risk concept economic implications of broad testing and interventions as well as patients perception of the concept of risk prediction expected impact we will develop prototype solutions for privacypreserving aibased data analysis for research and clinical application and will test a first proofofconcept low threshold intervention in ra and ibd our approaches will provide a clear health benefit to the citizens of the eu by improving health outcomes empowering joint decision making and contributing to appropriate action plans to reduce the avoidable burden of the diseases
the molecular mechanisms of dna methylation reprogramming in arabidopsis sexual lineage

in flowering plants dna methylation reprogramming occurs in meiocytes through rnadirected dna methylation pathway rddm mediated by 24nucleotide small interfering rnas sirnas my host lab discovered that these sirnas are transcribed from transposable element te in tapetal cells tapetum and transported to male meiocyte in meiocytes these sirnas induce methylation at genes metgenes with similar but not identical sequences and thereby regulate metgene expression and promote meiosis the ability of sirnas to target loci with reduced sequence homology is unique to meiocytes in tapetum and somatic tissues rddm only targets te with perfect sequence homology to sirnas the broadtargeting competence of tapetum sirnas allows the targeting of metgenes and fastevolving te in meiocytes however it is unclear how the broad targeting is achieved and comfined to the meiocytes my preliminary work discovered several meiocytespecific rddm homologues which i hypothesize to permit sirna mismatch targeting furthermore i found that rddm mutants are hypersensitive to heat stress in meiocyte development suggesting rddm mediates heat stress response in meiocytes harnessing singlecell multiomics biochemistry and bioimaging approaches i aim to 1 identity germlinespecific rddm homologues responsible for metgenes targeting 2 decipher how methylation of metgenes are mediated by lncrnas and 3 uncover how the methylation reprogramming of metgenes contributes to mediating male germline thermotolerance my discoveries will elucidate essential sirna regulatory mechanisms that mediate intergenerational heredity in plants and establish a novel epigenetic paradigm in how meiocytes perceive and respond to heat stress essential knowledge for building crop resilience under climate change this indepth knowledge of cell and sitespecific rddm pathway will also inform the generation of novel crop improvement tools by the engineering of methylation at gene families
coherent phenomenon in rydberg atoms

the project is devoted to theoretical studies of coherent optical phenomena in multilevel rydberg atoms under external magnetic field by using vortex beams the applicant will investigate the paritytime pt symmetry condition via optical vortex light in rydberg atoms then he will proposed a novel model for efficient transformation of the probe energy from zero order of diffraction to the higher orders in the pt symmetry condition after that he will propose a model for measurement of external magnetic field as well as orbital angular momentum transfer in a rydberg atom via optical vortex light it is expected that these studies will lead to future feasible experiments and have technological impact on quantum photonics applications in eitbased devices storage and manipulation of light quantum computing and information in addition the project will contribute to the personal and professional growth of the fellow via training of his communication management and other soft skills
violence and happy endings in the spanish golden age narrative

the purpose of this project is to study the complex integration of violence in the spanish golden age happy ending narrative in the idealistic spanish narrative genres of the second half of the 16th and the first half of the 17th century such as the pastoral and the courtly novel the inclusion of violence is problematic it is useful to create a gripping plot but must be solved to reach a happy ending the project will propose the concept of economy of violence to study the narrative structure of these genres and will analyze the strategies to deactivate and legitimize violence that allow these plots to resolve into a happy endingbeyond the literary approach the project has the ambition to propose a multidisciplinary understanding of these strategies bringing together literature historical sociology and gender studies considering the social structures of the golden age spain together with the concrete context of production and consumption of these genres almost always written by men and widely consumed by women the project intends to provide a critical analysis of what was presented as a happy ending and an ideal solution to violence particularly to genderbased violence through these plots this panorama will be completed with a separate study of the courtly novels written by women and an analysis of how the narrative schemes produced by the male hegemonic culture and the traditional happy endings were transformed or even rejected in their narrative productionthe project has two main objectives on one hand from a literary perspective it aims to arrive at a better understanding of the idealistic narrative genres of the spanish golden age through the concept of economy of violence on the other hand from a sociohistorical and a gender perspective it aims to analyze the interplay between the dictates of the spanish patriarchal society of the 16th17th centuries and the structure of the idealistic narrative of this period
bacteria intrinsically orchestrated with designed enzymes for sinergistic rateaccelerated plastic degradation efficiency

plastics are one of the most widely used materials with a wide variety of applications across all sectors of the economy its production is estimated to be around 360 million tonnes and thus synthetic polymer is poorly biodegradable plastic life cycle is responsible for greenhouse gas emissions contributing to climate change plastic waste has been found in every ecosystem are broken down into small pieces microplastics which can have a negative impact on organisms and altogether causing an unprecedented ecological crisis we aim to tackle this problem through bacteria intrinsically orchestrated with designed enzymes for sinergistic rateaccelerated plastic degradation efficiency bio degrade project using a novel application of biotechnologicalbased approaches to synergistically increase the efficiency limits of multienzymatic solutions the project will perform genomic modification of microorganisms with their own evolved collection of computationallyengineered proteins for microplastic degradation we are not engineering single enzymes to enhance their catalytic activities as it will computationally design multitude hundreds of proteins from the microorganism and boost them with extra catalytic sites making them into plurizymes the additional active sites able to degrade plastics will designed into the proteins employing advanced molecular simulation techniques such protein energy landscape exploration pele together with machine learning methods in this way the proteins will not be from other microbial origin heterologous but their homologous proteins to which an extra activesite capable of hydrolysing microplastics will be designed and genetically added not altering the gene expression pattern of the microorganisms these organisms will outperform the use of single enzymes because of the synergistic action of multiple evolved enzymes with one common goal microplastic degradation
music religion and civic identity in renaissance avignon c15001630

this interdisciplinary project will reveal how musical life in renaissance avignon c15001630 was directly interlinked with events happening on a broader religious social and political level alongside being the first indepth study of avignons musical life during this period it represents a significant and muchneeded departure from the parisianroyal court focus that has typified almost all previous scholarship on french renaissance music two fundamental issues will provide the basis for this investigation a the question as to whether avignons musical life can be said to reflect localised andor nationalised trends and b the effect that avignons unique status as a papal enclave had on its institutions and musical practices for example in the presence of italian personnel or musical developments these broader issues will serve as a backdrop for exploring the full spectrum of musicians professional activities as well as the various contexts within which they made the city resound ie from its ecclesiastical establishments such as notredame des doms cathedral and the collgiale saintagricol to the instrumentalists attached to the citys guilds to the various civic spectacles within which musicians participated like ceremonial entries the results of this innovative survey will thus constitute a major contribution to the fields of early modern soundscapes and cultural studies by extension they will also shed new light on avignons urban identity at this time thereby leading to a better understanding of music making in france during the long sixteenth century
mycorrhizal types and soil carbon storage a mechanistic theory of fungal mediated soil organic matter cycling in temperate forests

the worlds soils are the largest terrestrial reservoir of organic carbon c feedbacks between soil organic c and atmospheric co2 will determine the future trajectory of climate change however predictions are largely uncertain because we still lack fundamental knowledge of the complex interplay between plants and microorganisms and its influence on c turnover most terrestrial plants live in symbiosis with mycorrhizal fungi previous work suggests that on a global scale soil c stocks are linked to the distribution of arbuscular mycorrhizal am or ectomycorrhizal ecm plants to date it is not clear whether there is a causal relationship between mycorrhizal type and soil c storage answering this key question requires novel concepts that consider the mechanistic link between shortterm c fluxes from plants to mycorrhizal fungi and c storage as an emerging ecosystem property mycosoilc will yield a comparative systematic understanding of the dynamics of c input by mycorrhizal fungi to soil their effects on c turnover and their implications for c storage in temperate forests dominated by am or ecm trees achieving this ambitious goal which involves a multitude of processes on different spatiotemporal scales requires the development of groundbreaking technological innovations key innovations of mycosoilc are 1 realtime visualization of 11c allocation in plantsoil systems 2 construction of the first moving greenhouse for 13co2labeling of miniforests 3 coupling of quantum dot nanotechnology with isotope labeling to visualize organic nutrient uptake by fungi and 4 combining isotope analysis with biomarker approaches to quantify the fungal necromass contribution to soil c the mycosoilc approach bears significant conceptual and technical risks which are mitigated by a response plan with alternative routes mycosoilc will create substantial knowledge on mycorrhizal mediated c turnover and facilitate predictions of soilclimate feedbacks
towards a mechanistic understanding of nanoparticle interactions with exosome secretion

in recent decades considerable progress has been made in bionano research towards a growing understanding of the interaction mechanisms between nanoparticles nps and living systems yet the impact that cellinternalised nps have on exosome secretion remains largely unknown exosomes are ubiquitous cellreleased vesicles seemingly involved in numerous biological processes including regulation of cellcell communication and disease progression this enigmatic functional complexity is under the spotlight of a large scientific community in the fields of chemistry biology and nanomedicineonly recently it has been reported that in vitro cellular uptake of platinum and iron oxide np clusters 100 nm in size significantly increases the release of exosomes and alters their composition however it is unclear whether this evidence reflects a general behaviour or depends on the design of the nps a strong need thus arises to explore the mechanistic details of this interaction inspired by this challenge nanoexos aims to develop a novel framework to obtain a better and more general understanding of how engineered nps interfere with the regulatory processes of exosome formation and release npcell studies will be undertaken in vitro to focus on the effects that nps have on cellspecific exosome samples importantly nanoexos will systematically investigate how this interaction depends on the properties of nps eg welldefined size shape surface modification their biomolecular interactions and their cellular entry mechanismoverall nanoexos will contribute to expanding our knowledge of how exogenous nps are processed by living systems a thorough comprehension of how nps access and alter key cellular machineries such as exosome secretion plays a pivotal role in the biological evaluation of these nanomaterials this research question is crucial to establish safe and robust biological control over advanced npassisted diagnostic and therapeutic strategies
maritime low emission network

marlen maritime low emission network will be a partnership of european ministries and funding organisations responsible for funding rtd in maritime technologies from european countries the objective of this initiative is to strengthen the european research area in waterborne research by coordinating and developing synergies between national and regional maritime research programmes and policies in line with the aims of the partnership zero emission waterborne transport zewt the activities will include exchange of information and knowledge among national programme owners and programme managers as well as the implementation of distinct joint activities marlen shall further deepen broaden and strengthen the already established transnational cooperation based on the experience gained and some existing cooperation structures new organisations from several partner countries will broaden the network of maritime ministries and funding organisations with the knowledge of former initiatives lessons learnt especially from the previous martera project are taken into account in this proposal aimed at improving and intensifying the transnational cooperation and most importantly consolidating it in such a way that it becomes selfsustaining further objectives are the broadening deepening streamlining and strengthening of the joint activities including strengthening the existing ongoing transnational research to cover the whole innovation chain from science to business by launching new transnational activitieshowever to fulfil the ambitions of the waterborne transport sector it is obvious that much more research development innovation rdi and investments will be necessary in the coming years to address and respond effectively to the current and future climate and environmental challenges while taking into account a safe implementation of technologies and concepts