Dragon09/odtu_chatbot huggingface dataset:
tracing nanoparticlefuelled comobilization of catalyst metals across earths deepsea redox interfaces to pave the way for habitability detection in ocean worlds

redox metals such as fe mo v ni cu and mn supplied from deepsea interfaces played a pivotal role in the coupled evolution of earths biogeochemical cycles and life accordingly future search for life in ocean worlds of the solar system will greatly benefit from going beyond parameters such as water and organics and being able to detect signs of subsurface metal catalysis as fundamental metabolism requires metal clusters and nanoparticles their formation detection and link to earths ocean biogeochemical structure can pave the way for inference of metal catalysis from plume ejecta compositions of ocean worlds such as europa and enceladus deeptrace will advance a groundbreaking mechanistic analytical and predictive framework on the nanoparticlefuelled comobilization of catalyst metals across earths marine redox interfaces the key idea is to establish the concept of subocean metal redox catalysis underpinning the ecosystem evolution of earths oceans and use it to explore habitability of ocean worlds in deeptrace we will conduct multidisciplinary sea expeditions to unravel how the six redox metals comobilize by studying earth analogues such as deepsea hydrothermal vents and suboxicanoxic seas integrating stateoftheart methods with emerging innovative approaches such as timeofflight singleparticleinductively coupled plasma mass spectrometry we will advance the multielement detection of nanoparticles finally to build a predictive framework that will enable the estimation of nanoparticle fluxes from deepsea boundaries and inferring the metabolic potential of ocean worlds we will develop novel biogeochemical models deeptrace will tap the potential of tracing redox metals as one of best opportunities in the next decade for detecting life in ocean worlds and accelerate improved parametrizations of metal cycles for better prediction of earths marine ecosystems under multistressors such as deoxygenation warming and biodiversity loss
phase time and correlations in free electron wave packets

electron emission from matter is a widespread phenomenon in nature with examples including the photoionization of atoms and molecules photoemission from solids and the release of electrons due to ionizing radiation in biology complete information about the emitted electrons is contained in the amplitude and phase of their wave packets while stateoftheart electron spectroscopy routinely accesses the amplitude of these wave packets the phase of free electron wave packets remains inaccessible my team and i aim to develop an experimental technique to measure the phase of free electron wave packets without interfering with their creation mechanism this will be groundbreaking as the phase of the free electron wave packet carries information about the quantum mechanical properties of photoionization and the electron in its bound state prior to ionizationwe will accomplish this task by constructing a novel microscopic ultrafast freeelectroninterferometer in which replicas of the initial free electron wave packet are generated shifted in momentum space and brought to interference at the heart of this innovative interferometric scheme are two crossed pulsed standing light waves that interact with the wave packet after its creation on femtosecond timescales we will scale this approach to be applicable to correlated fewbody wave packets by combining the light field interferometer with coincident multiparticle detection in a coltrims reaction microscopeemploying this groundbreaking method we will address three objectives 1 we will investigate the time evolution of the phase of an atomic photoelectron wave packet with a linear and with a helical interferometer made from light carrying orbital angular momentum 2 we will study wave packets emitted from molecules including chiral molecules 3 we will examine correlations and entanglement within twoelectron wave packets and between photoelectrons and their parent ions
growing up across borders experiences of young people in forced migration

since 2015 over 5 million people have arrived or tried to arrive in the european union seeking refuge other refugee receiving countries are faced with similar situations many of these refugees are young people but whilst much has been written about the experiences of adult refugees and to a lesser extent about unaccompanied minors there is very little research on the experiences of young refugees who are not or are not recognized as unaccompanied and specifically about how these experiences impact their pathways to adulthood in or across borders this in turn leads to an absence of effective policies to protect young people and to ensure their access to services which are essential to their wellbeing both as young people and for their future adult lives the project aims to provide timely new research focusing on various aspects of the experience of these young people growing up in a situation of forced migration in order to contribute research both on youth and on migrationmobility in doing so it will also make recommendations on how to better support rights agency and resilience of these young people the research will be carried out in a range of countries in europe france greece uk and outside canada south africa to analyse impacts of different social legal and political contexts the development of innovative methodologies combining traditional qualitative methods with social media research and digital communication tools and emphasizing participatory research methods will enhance the participation and selfexpression of young refugees to allow them to narrate their lives and experiences a feminist intersectional approach avoids essentialising young people as vulnerable and understands age as interacting with other social categorizations such as gender or race to determine individuals risks vulnerabilities but also possibilities for agency and resilience
personalised medicine the evolution of healthcare for improving peoples lives

the project pm4future aims at organising a conference on personalised medicine with the overarching objective of identifying challenges and opportunities for the implementation of personalised medicine in the healthcare as well as gaps on research and funding the event organised by the spanish foundation for science and technology fecyt on behalf of the spanish ministry of science and innovation mcin and with collaboration of the institute of health carlos iii isciii the centre for the development of technology and innovation cdti will be held on october the 4th and 5th 2023 in valencia the agenda will focus on three main axes 1 prevention diagnostics and treatment of diseases through a personalised approach 2 tools for personalised medicine the role of federated transnational research infrastructures in the research and development of pm and 3 international cooperation as an element to promote the development of personalised medicine in african and latin american regions
programming the epicardium to cure broken hearts

cardiac diseases are the leading cause of death worldwide making human cardiac regeneration one of the most critical unmet clinical needs the epicardium the mesothelial envelope of the heart is the source of several cardiac cells and provides signals that are essential for myocardial growth and vessel formation during development extensive animal research has indicated that the reactivation of these embryonic epicardial programs is the key to adult tissue repair in regenerative species such as the zebrafish as well as in rodents up until a few days after birth before the hearts capacity for regeneration is lost how the human epicardium develops and responds to injury is largely unknown we recently established the first human pluripotent stem cellbased cardiac organoids showing the selforganization of epicardium and myocardium into a functionally patterned structure resembling the embryonic ventricular wall these epicardioids offer unique possibilities to study the dynamics of human epicardium development and function at a singlecell resolution epicure aims at decoding and harnessing these programs as potentially transformative means for human heart regeneration stateoftheart lineage recordings 3d imaging and spatial multiomics in epicardioids will be used to dissect the fate acquisition mechanisms of the human embryonic epicardium and identify critical signalling pathways in health and disease this in vitro approach will be complemented by charting a spatiotemporal crossspecies singlecell atlas of the cardiac injury response ex vivo and in vivo including the first genetic lineage tracing of the adult epicardium in a large animal model finally we will capitalize on the novel concept that crisprmediated temporal programming of the epicardium could drive meaningful heart regeneration in adulthood clearly epicure will yield a wealth of new insights into human epicardial biology while breaking new ground in cardiac regenerative medicine
first nearterm applications of quantum devices

quantum technologies have set remarkable milestones in the last years eg with quantum advantage experiments and loopholefree bell tests despite this progress the quantum devices we currently have the socalled noisy intermediatescale quantum nisq devices are too imperfect to run textbook quantum algorithms yet they hold great potential with their advent much research has been devoted to finding them a first practical application focus on optimization quantum chemistry and machine learning has been intense and the developments are closely monitored by governments and industry alike variational algorithms in a classicalquantum feedback loop and adiabatic algorithms have been the dominant paradigm however important bottlenecks remain that severely maim the performance of nisq devices and the field yearns for a novel approachfineteasquad first nearterm applications of quantum devices proposes a radically new vision to develop a unifying framework that will yield the first practical applications of nisq devices the main objectives are a to design experimentallyfriendly protocols for quantum state preparation circumventing major existing bottlenecks high number of repetitions noiseinduced barren plateaus and characterize broad families of states that can be prepared in a scalable way b to develop a practical certification toolset amenable to nearterm devices with especial focus on the generation of certified randomness from a single nisq device the key idea is to use the hardness of manybody physics in a classical verifierquantum prover interactive protocol this approach will overcome the existing limitations of current approaches it will be both easy to prepare and easy to verify c to overcome current hardware scalability limitations by combining several nisq nodes into a small quantum network and develop the appropriate theoretical framework to efficiently tailor and run quantum algorithms on them
lipid diversity at the onset of life

the origin of cell membranes is a major unresolved issue in evolution evolutionary biology points to the existence of primitive cells with compositionally diverse membranes that could actively participate in genetic and metabolic processes however the assumption that such lipid diversity is dependent upon enzymatic chemistry has generated models comprising compositionally minimal membranes binary or ternary mixtures of shortchain fatty or phosphatidic acids that passively host genetic or metabolic processes lipdive seeks to reconcile biology and chemistry by challenging the critical limiting assumption that lipid diversity cannot be achieved through nonenzymatic prebiotic chemistrieslipdive will identify prebiotic chemistries that could have given rise to compositionally diverse membranes and show how these support characteristic behaviours necessary for nucleic acid replication and membrane division the hallmarks of a cell cycle to achieve this goal i will harness diversityoriented prebiotic synthesis to nonenzymatically transform primitive pluripotent lipids into libraries of diverse lipids wp1 these lipids will be used to build compositionally diverse membranes wp2 capable of interacting with membraneediting protoenzymes and ribozymes wp3 coupling membrane division and nucleic acid replication will ultimately lead to a primitive cell cyclelipdive will advance the stateoftheart in the originsoflife field by probing the emergence assembly and evolution of cell membranes and finally connecting prebiotic chemistry and early biology lipdive will lead to i a fundamental understanding of the origins of lipid diversity including the features now associated with bacterial and archaeal lipids ii new strategies based on compositionally diverse membranes to probe sense or replicate cellular behaviours and iii a deeprooted understanding of the emergence and evolution of cellular processes at the molecular level
urban adaptation and alert solutions for a timely reaction

natural and humancaused disasters including uncontrolled urbanization pose multiple shortterm and longterm risks such as building inhabitants being vulnerable to heat or cold waves older people or other vulnerable individuals struggling to reach safe places during emergencies and citizens not receiving timely alerts from public authorities regarding impending flash floods or firestorms among others the retime project aims to address impactful changes at both the contextual district level and individual homes it will introduce a datadriven tool that aggregates existing data from weather stations sensor networks and satellite images automated onsite surveys to simulate the impacts of current phenomena and future projections the innovative aspect lies in an advanced computational analysis that generates prospective scenarios based on socioarchitectural and environmental studies combined with local territorial remote and onsite surveysretime will develop a suite of 4 innovative adaptation solutions for reducing risk in urban areas 1 a sensorbased it automated alert system 2 a digital building twin dbt 3 a digital building renovation passport brp 4 a resilience knowledge hub and decision support platform these tools will be sensitive and capable of prioritizing alerts based on the architectural and societal contextspecific features in three pilot areas in portugal slovakia and estonia retime will meet citizens realtime needs while supporting control and decisionmaking processes by identifying vulnerable groups and critical hotspots enhancing building resilience utilizing existing datasets and forecasting computational tools delivering adaptation plans with a focus on carbonneutral lifecycle awareness and increasing citizens understanding of natural disasters and their multiscale impacts overall retime strives to create a more resilient informed and prepared urban environment for all citizens
futureproofing heritage buildings by optimising comfort and energy in time and space

the heritace project brings together a transdisciplinary team of research institutes authorities smes and industry experienced in design technology and policymaking in the domains of conservation buildings and energy a significant increase in deep renovations of heritage buildings has the potential to lead to effective energy demand reductions and readiness for the transition to r2es based on prior research and field knowledge supported by various eu and national projects bottlenecks have been identified that prevent the futureproofing of heritage buildings and its replication to overcome them heritace proposes innovative technical solutions integrated into a holistic and multiscale renovation approach by developing and validating 1 a replicable holistic assessment model and standardised processes to create a holistic vision and plan on the renovation requirements for heritage townhouses in historical neighbourhoods 2 optimal and integrated design approaches for the deep renovation of heritage townhouses with wellconsidered targeted and minimal invasive renovation measures 3 durable insulation and air tightness solutions for the renovation of building envelopes respecting their heritage values and traditional building technology 4 optimised and smart controlled hvacconcepts adapted to heritage townhouses optimising comfort and indoor air quality precisely where and when the building users need it and 5 integrated resbased energy supply solutions maximising the share of local res in heritage buildings within historical neighbourhoods the project will deliver solutions for authorities and designers to envision and govern a sustainable energy future for heritage townhouses in historical neighbourhoods thus putting the eu green deal and new european bauhaus into practice close collaboration between researchers smes and industry shall increase the availability of highquality solutions for the building conservation sector
coldspark driven energy and costefficient methane cracking for hydrogen production

the coldspark project will validate a novel nonthermal plasma technology to produce hydrogen at an industrial scale from methane with a process energy efficiency of 79 achieving a conversion rate of 85 with zero co2 emissions this will be achieved by designing an industrial relevant reactor that leverages the best features of the nonthermal plasma technologies gliding arc and corona discharge to ensure high efficiency and scalability the innovation addresses for the first time the critical step of matching the reactor with a pulsed power supply it enables a perfect finetuning of the cracking process parameters to find the right electron density and energy distribution in the plasma reactor to maximise energy efficiency the up and downstream gas management will be optimised to further contribute to the systems compatibility to existing infrastructure the project will develop and test a novel plasma reactor at lab scale and validate it in conjunction with the power supply at largescale pursuing the industrys most power efficient generation of hydrogen alongside highvalue carbon the technology will assess its application for both natural gas and biomethane producers a low energy cost 15 kwhkg h2 produced without the need for catalysts and water makes the proposed solution the most costcompetitive environmentfriendly and less complex to implement the reactor design and modularity bring lower capex and opex and make it easily scalable and flexible the project gathers the expertise of a mix of academic research and industrial partners from five countries which bring both outstanding research and topic competence as well as knowledge and access to the solution for enduser industries
scaling extreme analytics with crossarchitecture acceleration based on open standards

the widespread adoption of ai and analytics has resulted in a rapidly expanding market for novel hardware accelerators that can provide energyefficient scaling of training and inference tasks at both the cloud and edge unfortunately all popular solutions ai acceleration solutions today use proprietary closed hardwaresoftware stacks leading to a monopolization of the ai acceleration market by a few large industry players the vision of syclops project is to enable better solutions for aidata mining for extremely large and diverse data by democratizing ai acceleration using open standards and enabling a healthy competitive innovationdriven ecosystem for europe and beyond this vision relies on the convergence of two important trends in the industry i the standardization and adoption of riscv a free open instruction set architecture isa for ai and analytics acceleration and ii the emergence and growth of sycl as a crossvendor crossarchitecture data parallel programming model for all types of accelerators including riscv the goal of project syclops is to bring together these standards for the first time in order to i demonstrate groundbreaking advances in performance and scalability of extreme data analytics using a standardsbased fullyopen ai acceleration approach and ii enable the development of interoperable open and vendor neutral interfacesapis trustworthy verifiable and standardsbased hardwaresoftware and green via applicationspecific processor customization ai systems in doing so we will use the experience gained in syclops to contribute back to sycl and riscv standards and foster links to respective academic industrial and innovator communities riscv foundation epi khronos iso c bringing together the two standards enables codesign in both standards which in turn will enable a broader ai accelerator design space and a richer ecosystem of solutions
the orbem genus aipowered imaging technology for fast accurate and contactless object classification analytics

poultry is humanitys most important source of animal protein yet it is extremely difficult to optimize the eggs in chicks out process resulting in the waste of billions of eggs incubation hours and lives of male chicks at orbem we are developing the genus aipowered imaging technology that enables poultry companies to solve their toughest challenges we use mri to collect data from inside eggs and process the data with ai to provide access to hidden sources of knowledge at the pedigree level breeding companies use the data to develop the next generation of poultry with better quality at the commercial level we automatically classify eggs according to different criteria including fertilization status inner quality and the sex of the developing embryos we can prevent the waste of billions of eggs dramatically increase hatchability and stop the culling of male layers transforming poultry into an efficient sustainable and animalfriendly industry
datadriven method based on a process mining approach for automated digital twin generation operations and maintenance in circular value chains

the transition towards a circular economy is estimated to represent a 45 trillion global growth opportunity by 2030 digital twins availability is largely recognized as an accelerator and an enabler of circular economy in business and in production but significant challenges are still standing in relation to its development within the present technological framework the needed skill sets and the implementation costs autotwin addresses the technological shortcoming and economic liability of the current systemengineering model by 1 introducing a breakthrough method for automated processaware discovery towards autonomous digital twins generation to support trustworthy business processes in circular economies 2 adopting an international data space idsbased common data space to promote and facilitate the secure and seamless exchange of manufacturingproductbusiness data within valuenetworks in a circulareconomy ecosystem 3 integrating novel hardware technologies into the digital thread to create smart green gateways empowering companies to perform data and digital twin enabled green decisions and to unleash their full potential for actual zerowaste circular economy and reduced dependency from raw materials