Dragon09/odtu_chatbot huggingface dataset:
the role of fungal viruses in shaping fungal pathogenesis and mammalian host responses

fungal pathogens present a significant threat to global health as eukaryotes they share considerable homology with their hosts necessitating the development of innovative noncrossreactive therapies mycoviruses viruses of fungi can transform fungal virulence yet despite their ubiquity and importance the underlying mechanisms driving mycoviral infection and their consequences on fungal pathogenesis remain understudied using a naturally mycovirusinfected aspergillus fumigatus strain a model human fungal pathogen we found that the mycovirus bestows a survival benefit to the fungus under oxidative stress and in the murine lung we posit that mycoviral pressure modulates fungal fitness and virulence thereby shaping the fungal host repertoire and facilitating the emergence of new fungal diseases the proposed research aims to elucidate the mycoviral fungal and mammalian determinants governing fungal cell fate during infection we will1 determine the molecular details governing mycoviral impact on fungal fitness virulence and host adaptation 2 identify fungal antiviral mechanisms and 3 determine how mycoviral infection affects the mammalian antifungal response this complex multipartite pathosystem mycovirusfungal hostmammalian host is highly heterogenous and dynamic and this diversity can trigger different infection outcomes to this end we have developed a suite of fluorescent probes of fungal and mycoviral infection and of fungal physiology that enable tracking of virusfungushost interactions at singlecell resolution and assessment of the physiological state of phagocytosed fungi in the host tissue we propose the first in vivo interaction map of a virus within a fungus within an animal in the context of in vivo infection we anticipate that this work will fundamentally shift our paradigms of fungal pathogenesis and lay the groundwork for the development of novel therapeutics that operate in an entirely unexploited target space
organoids for heartbreak

this project is a proofofconcept study for organoid drug testing platform for disease modeling of cardiac fibrosis i am going to develop a cardiac organoid on chip platform for disease modeling of cardiac fibrosis to identify the molecular mechanism of the pathologic interplay between endothelial cells cardiomyocytes and cardiac fibroblasts and its regulation by specific drug treatments this model will be based on cardiac organoids previously developed at the host lab modified with endothelial cell component organoids with and without endothelial cells will be a tool for identification of endothelial contribution in cardiac fibrosis molecular mechanisms will be identified through selective interventions in known fibrotic pathways with special focus on the reninangiotensinaldosterone system in addition validity of this tool for drug testing will be established by proofofeffect of known medications on fibrotic molecular phenotype and cardiac function the platform will be designed as medium throughput for patient treatment optimization precision medicine and drug testing collectively it has the potential to replace animal models in mechanistic research and drug development the host lab is the perfect fit for this project it has been on the forefront of cardiac organoid research and their previous work is the cornerstone for the cardiac organoid model used here they possess the latest equipment for onchip organoid cultivation and have extensive experience with augmentation and optimization of biopolymer hardness to simulate fibrotic environment additionally prof sluijters professional network of contacts and cooperation with local university spinoff companies provides the opportunity to investigate the interest of the industry in application of this project by scaleup of our drug testing platform for high throughput organoid drug screening platform
refuelling heavy duty with very high flow hydrogen

there is a strong demand from eu to decarbonise freight transport rheadhy will contribute to this by developing highperformance hydrogen h2 refuelling stations rheadhy aims at fully implement and validate new refuelling protocols that will allow to refuel 100kg h2 trucks in 1omin partners will design and assembly a new very high flow refuelling line for 700bar h2 truck to do so they will develop missing key components needed to reach the mean flow target of 170gs 300gs at peak the unique rheadhy comprehensive approach will guaranty an optimal design of components and refuelling line by gathering in the consortium bestinclass partners manufacturing all the components downstream highpressure refuelling station storage to vehicle storage this approach will allow to choose the optimal tradeoff on constrains repartition among components and to fully consider vision of real vehicle constrains new implemented refuelling protocols are based on previous work prhyde and standardization committee work and involve calculation of refuelling coefficients specific to vehicle storage that need to be derived from hundreds of simulations this extensive simulation work will be performed on refuelling model validated in previous european projects to dedicate at least 15 years to an extensive test campaign components and refuelling line design manufacturing and assembly will be achieved within 2 years 2 refuelling stations will be installed in france and germany within the first 25 years 2 truck storage test systems will be used to test and validate refuelling protocols on full scale storage this work will allow to provide feedback from the field to significantly contribute to the establishment of standards on refuelling interface components and protocols rheadhy will then represent a significant step forward to unlock h2 truck market by allowing wide and performant refuelling station network based on european alternative fuel infrastructures ambition
intraoral scanning in dental caries

caries disease is a global health and economy burden experienced by 2 billion of adults and 500 millions of children around the world visual exam and dental radiography are the standard methods for diagnosing and monitoring dental caries and present shortcomings subtle lesions of caries cannot be visual or radiographically detected and are highly sensitive to the examiner besides it xrays involve ionizing radiation which limits monitoring at small intervals and has structures superimposition recently trios 4 3shape copenhagen denmark intraoral scanning ios brings caries aid monitoring tool based on fluorescence and infrared technologies despite in vitro studies suggesting its applicability there is no clinical evidence of its accuracy true positives and negatives in this context the goal of this project is to clinically assess the accuracy of this novel approach for detecting and monitoring dental caries after ethics approval i will examine patients teeth under dental caries treatment in faculty of dental surgery of university of malta using visual exam and dental radiography then i will scan teeth with trios 4 ios using fluorescence and infrared technologies using these clinical digital data i will output 1 the accuracy of trios4 compared with standard methods 2 if the result changes between professionals in a multicentre approach if firmly established it will be a way to change caries monitoring in a safe and noninvasive approach if not it will provide scientific evidence for improvement future studies and development of new tools the results will be interesting for scientist dentists industry and citizens as caries is a common disease with high global prevalence for reaching such audience communication dissemination and exploitation is planned using open access practices through data repository green and gold routes as well as in mass media
advanced manufacturing of selfsensing biobased membranes for environmental detoxification and revalorization

among the myriad of toxics that contribute to water toxicity heavy metals derived from mining have a huge impact in our environment even at very low doses in parallel mines play a pivotal role in the industrialtechnical development of our societies usually mining acid drainages or polluted waters are accompanied by critical raw elements cre today passive disperse alkaline dispersed alkaline substrate das reactors is one of the technologies trl9 that blocks the scape of these toxic elements from mines for instance heavy metals and valuable metals cre are concentrated at different levels of das reactors during operationso envisioning a technology able to develop a circular economy for mining water by coupling its remediation to the recovery of valuable resources concentrated in das is highly appealing from environmental end economic point of views selfaquasens project brings key academic and nonacademic actors within and beyond eu to develop a modular selfsensing filter and membrane technology able to i remediate heavy metals and salinity pollutions in mining water ii couple the remediation to the recovery of cre and ii sense the concentration of specific elements or groups of elements during the processselfaquasens joints varied interdisciplinary and intersectoral expertise in an international research and training network formed by 5 universities 2 large scale research facilities 2 research centers and 2 smes as a result the ri system of europe will be strengthened by an ambitious exchange and training program that covers all the research disciplines sectors and international actors needed to achieve the objectives of the action the project will have significant impacts in the short to long terms into the eu society economy and environment by i pursuing the mission for toxicfree rivers and oceans creating new sources of cre for the eu economy and improving the health and quality of the eu citizens
realtime coevolution in a multitrophic community under current and future climates

in nature organisms live in communities and form complex trophic interactions understanding how multitrophic communities evolve and respond to environmental changes is a fundamental and pressing challenge in face of global change while research in evolutionary biology revealed that a warming climate can drive adaptive evolution of individual organisms in the community studies from community ecology showed that a warming climate can alter trophic interactions and community structure which in turn changes the coevolutionary trajectory of interacting species thus integrating evolutionary and ecological responses is crucial to understand the climate responses of individual species and communities however methodological challenges have hampered empirical studies until nowevolcommunity will address these challenges by experimentally evolving populations of three interacting species aphid duckweed and daphnia in their native communities using outdoor mesocosms with different climate conditions we will quantify how warming shapes the function and evolution of the multitrophic community in realtime by manipulating climatedriven plant evolution we will determine whether plant evolution alters the communitys response to climate change we will also assess whether the interacting species coevolve in the community by quantifying the reciprocal selection imposed from their evolutionary changes we will investigate the molecular mechanisms underlying coevolution using stateoftheart genetic toolsusing a combination of experimental evolution community manipulation and cuttingedge genetic and analytic tools evolcommunity will push the research boundaries of evolutionary ecology by revealing the mechanisms and processes of community evolution at work the outcomes will open new research avenues in evolutionary ecology by establishing a new methodological framework that integrates evolutionary biology and community ecology in natural communities
safer and more reliable wbguwbgbased mvdc power converters

electrification coupled with renewable electricity supply is a key pathway to achieve a deep decarbonization of our society and contribute to an energy transition in a sustainable way the electric energy demand based on distributed renewable sources is going to be even more important and a more efficient secure flexible and affordable energy distribution should be envisaged for the next future if these requirements are not met the replacement of wellestablished solutions based on fossil fuels will be unfeasible consequently apart from the evident environmental impacts collateral effects could occur such as great blackouts at national and continental level in this scenario safepower first explores and investigates on essential digital enabling and emerging technologies to achieve a new generation of power converters for solar applications i capable of anticipating failures to prevent downtime using effective condition and health monitoring chm solutions assisted by ai strategies ii based on more compactlypackaged efficient rugged and affordable silicon carbide sic power mosfets diodes and solidstate dc breakers with a more sustainable manufacturing and iii prospecting on ga2o3based emerging power devices mesfets diodes and solidstate dc breakers especially designed for this application leveraging these technologies safepower studies and proposes new converter topologies and control schemes to enhance their compactness sustainability competitiveness and security additionally these technologies streamline costeffective maintenance through aiassisted intervention plans and aienabled limp mode operation with derating strategies which can be extended to offshore wind energy conversion therefore the adoption of safepowers technological solutions in the eu solar sector not only will establish a competitive advantage against noneu power converter manufacturers but also will enable their initial deployment within the eu
quantum interfaces with single molecules

isolating and addressing individual quantum systems has allowed for breakthrough results in quantum mechanics today increasing the complexity of the system while maintaining control at the singlequantum level is vital for the next generation of quantum devices and research quintessence will take up this challenge by developing interfaces between single photons spins and phonons all within one simple physical system ie a single moleculefundamental systems like molecules have the inherent advantage in comparison to artificial structures of being nominally identical a molecule can have the coherence properties of an atom even when embedded in a solid without losing the access and customization opportunities typical instead of the solid state molecules differ from atoms in being more complex systems with rich energy diagrams structured over multiple scales we propose to leverage this complexity to coherently connect optical frequency photons with microwave spin excitations and gigahertz phonons unprecedented control over the molecules degrees of freedom will be achieved by integrating them in nanostructured devices we will develop a groundbreaking labinamolecule platform benefiting from the tunability and scalability of molecules so as to aim at the following main objectives complex states of light integrating multiple molecular sources of indistinguishable photons on chip singlemolecule cavity optomechanics accessing the regime of singlephoton strong coupling in an unconventional cavity optomechanical system optical addressing of single molecular spins providing a crucial knob to read out and control the spin state of a single moleculequintessence will therefore allow us to entering unexplored quantum territories and to develop quantumtechnology tools unavailable today notably the outcome of this project will impact a broad scientific community touching quantum optics optomechanics and molecular quantum technologies
unravelling ultrafine particulate matter and micro nano plastics mechanisms of impact on fetal health

the uprise project aims to unravel the complex mechanisms by which air pollution in particular ultrafine particles ufps and micronanoplastics mnps disrupt normal fetal development leading to an increased risk of adverse birth outcomes abos including preterm birth increasing the risk of premature children to develop a range of noncommunicable diseases ncds in adulthood uprise will develop exposure databases and assessment models for these emerging pollutants in different exposure scenarios to improve our understanding of their sources concentrations and dispersion patterns uprise will include a clinical study with pregnant participants exposed to different levels of ufps and mnps pollution to analyse possible modes of action leading to abo based on transcriptomic epigenetic or mitochondrial mutation analysis and subsequently identify possible key events including molecular initiating events as a result causal models supported by weightofevidence analysis will be developed to demonstrate the link between contaminant uptake and events triggering the abo of interest to facilitate the dissemination of results and their application in policymaking uprise will develop userfriendly tools for reporting and sharing data with the aim of facilitating the integration of scientific evidence into the updating of european and national air quality standards by advancing in the quantification of the public health impact of prenatal air pollution exposure and providing guidelines and decision support tools for policy makers the project will contribute to reducing the burden of ncds associated with preterm birth and other abos
improving policy and legislative mechanisms for international investment to renewable energy transition

despite a global growth of investment in the renewable energy sector there is clear evidence that lawmakers have been unable to present a comprehensive legislative mechanism to develop the sector while policy makers have been unable to meaningfully provide institutional support by 2022 according to investment dispute navigator investors have launched 145 cases against governments inside and beyond the eu with a total claim of about 1018 billions to obtain compensation for the damages they had suffered because of weak legislative and institutional mechanisms such a situation has led to the postponement of 458 new renewable energy projects increase of energy poverty by 14 and growth of carbon emissions by 27 around the globe the ienergy project aims to improve institutional and legislative mechanisms thereby assisting investors in identifying reliable investment destinations and supporting states in ensuring investment trends and avoiding risks of investment disputes in the renewable energy sector the project will build an ienergy conceptual framework on the basis of an interdisciplinary approach and will develop and analyse a case studies container which will include data and information of cases concerning institutional and legislative mechanisms in the renewable energy sector finally the project will create and implement an ienergy toolset by applying empirical mathematical programming methods to test various hypotheses of institutional and legislative contents taken from the case studies container to identify legislative and institutional dispute resolution alternatives which meet the aims above
multiscale and multiphysics modelling of soft tissues

mechanics exerts significant influence on biological growth development and disease through multiphysical factors and at multi scales current modelling research in cancer growth spreading and morphogenesis lags far behind experimental studies and this gap has seriously hindered cancer diagnosis and treatment the advanced mathematical and computational modelling of soft tissue and cancerrelated phenomena combined with systematic experimental studies and robust numerical simulations are of great research significance to the health and economic values of europethe main goal of the multisoft project is to overcome these challenges in an original and innovative manner by developing multiscale and multiphysics modelling of soft tissues to improve our understanding of cancer and develop tools for its identification and treatment the work will be approached from theoretical computational and experimental perspectives based on the applicants and host laboratorys expertise the training program is exhaustive and will allow the applicant to grow as an independent researcher the proposed research will foster further development in this direction a step that is fundamental in healthcare and for the benefit of society the applicant is a chinese scholar with expertise in the areas of applied mathematics solid mechanics soft matter instability and bifurcation and multifiled coupling he has been trained in prestigious academic institutions in china ireland and the uk he publishes articles in highimpact factor and top journals at the frontiers of applied mathematics biomechanics and other disciplines he is requesting funds for two years to work with prof davide bigoni and his solid and structural mechanics group at the university of trento italy and secondment six months at the graz university of technology austria and the international school for advanced studies italy
quantum boundary conditions for infinitedimensional control

taking advantage of the underlying quantum features of the natural world to design new technologies is the principle at the root of the second quantum revolution quantum control theory provides the mathematical substrate to this principle by establishing precise conditions under which a system can be manipulated to reach any desired state in a finite time and developing systematic methods for accomplishing this goal in an optimal way this is a formidable task especially for systems with infinitely many degrees of freedom for which advanced mathematical techniques are neededthe standard approach to quantum control relies on the use of external fields a significant byproduct of such schemes is the possible loss of quantum correlations between the components of the system resulting from this interaction an alternative route is achieving control by exploiting boundary effects that is manipulating the boundary conditions of the system this is the idea at the core of quantum control at the boundary qcb a promising yet underdeveloped paradigmthe aim of the project is to investigate the feasibility and shortcomings of qcb laying the foundations to a systematic theory of boundary control schemes by adopting and improving known results from infinitedimensional control theory the project will elucidate the conditions under which specific qcb schemes including thick quantum graphs and cavities with moving boundaries are controllable the problem of optimal control and the practical implementation of such schemes will also be studied the project draws ideas and techniques from different areas of mathematics and physics by also requiring familiarity with the laws of quantum mechanics this reflects the scientific background of the applicant it will involve a significant transfer of knowledge to the host institution and the training of the researcher from a scientific and a managerial point of view