Dragon09/odtu_chatbot huggingface dataset:
multiscale dynamics on highorder networks applied to epilepsy

neurological disorders such as epilepsy affecting about 5 mill people worldwide are associated with deviations from the optimal network structure and dynamics epilepsy surgery costing 10003000 eur per surgery in eu countries consists in the removal of the minimum amount of tissue needed to stop seizure propagation but it is only successful in aprox 23 of the cases analyses of brain network structure and computational studies simulating seizure dynamics over it have related aspects of the patients brain network eg hub distribution excitability with surgery outcome however results are not always replicable and have not been able to surpass the current clinical standard in the mente which stands for mind in spanish project i will explicitly consider the previously neglected effect of highorder ho brain structure on seizure dynamics and epilepsy surgery i will characterize the ho brain structure of epilepsy patients via topological data analysis in relation to surgery outcome i will then create a ho computational model of seizure dynamics by extending pairwise multiscale ms neuronal models of ictal activity i will study the emergent behavior of the system via theoreticocomputational analysis to characterize the healthytoictal transition finally i will fit the model to intracranial eeg data of ictal activity and use it to model epilepsy surgery with the goal of predicting surgery outcome and finding alternative resection strategies smaller of with better outcome to reduce the societal and economical burden of epilepsy mente will validate the role of ho coupling on brain activity and promote the theoreticocomputational modeling analysis and application to neuroscience of network dynamics including ho and ms coupling the fellowship will strengthen mine and the hosts expertise these topics and allow me develop my academic career to the point of scientific maturity
emergent soil plant and food onsite digital services on chemical and biological contaminants

espfdigit will bring novel onsite digital tools already at trl5 under systemic innovation which will be further deployed upscaled fieldtested and demonstrated to trl78 in viticulture and horticulture applications in greece and spain in soilcontaminated areas located near mines offensive industries highways floodwaters espfdigit brings novel developed i mipbased electrochemical sensors coupled with spme for onsite monitoring and analysis of dedicated to pfas targeted molecules ii multiplex organic surface plasmon resonance optical biosensors for onsite pesticides residues monitoring and analysis iii idebased electrochemical sensors for onsite detection and quantification of heavy metals micronutrients and iv uvc led based nutrient analysers for soil water content insitu and real time monitoring the aidriven onsite digital tools will be model calibrated using machine learning algorithms to improve error distribution of a predictive model ensuring reliability also espfdigit brings an edgebased remote sensing framework via a robust autonomous mobile robot selfnavigating and a heavyduty unmanned aerial vehicle for infield detection of soil parameters regarding the aforementioned chemical and biological stressors finally to predict pesticide and fertiliser and other chemical contaminants impacts on cropsoilmicrobiome nexus the project will use onfield realtime digital ground sensors combined with earth observation data and causal machine learning all the onsite digital tools will be interconnected with a decision support systems with blockchain and cybersecurity mechanisms enabling informed decisions and automated decision making for ipm and inm enhanced with automated decision making for immediate soil management practices
high performance computational methods for the boltzmann equation

the boltzmann equation is highly important in mathematical modeling of physical systems large and small from galactic dynamics to electron transport its range of applicability exceeds that of wellknown continuum models such as the navierstokesfourier equations in particular the boltzmann equation can accurately predict rarefied gas phenomena which occur in a wide variety of hightech 21st century applications such as microelectronics plasma physics and high altitude flight while numerical methods for continuum models are well established numerical methods that accurately and efficiently solve the boltzmann equation are undeveloped the main objective of this research proposal is to enable threedimensional numerical simulation of rarefied flows by developing accurate and efficient numerical solution procedures for the method of moments to numerically solve the boltzmann equation the approach described herein is innovative and original as it is the first to exploit kronecker structure and structural properties of the boltzmann equation to improve efficiency the developed techniques will be consolidated into a high performance computing framework and applied for the first time to an industrial photolithography application the proposed research involves a privatepublic partnership between domain experts in the method of moments at the technical university of eindhoven tue and experts in photolithography at asml if awarded this proposal will allow me to lay the groundwork necessary to achieve a paradigmshift in numerical simulation of rarefied gas flows it could emanate into a successful line of research for the coming decade with academic as well as commercial interests aligned with my career goals i am highly motivated and uniquely positioned to carry out this research due to my specialistic expertise in efficient solution methodologies and my interdisciplinary training in mathematics computational science and engineering
new germaniunbased materials for green electronics

the current electronics present in everyones daily lives are made up of several different materials some of which are scarce toxic or even both developing new toxicfree widely available materials that could take part in the same processes would help the environment with less toxic elements being disposed of furthermore using widely available elements could also lead to a lower price making electronics more available throughout the worldthis project focuses on the synthesis of thin films of two materials which would be a world first formed of widely available nontoxic elements sr3geo and sr2mnge2o7 the first is a narrow band gap semiconductor and could replace highly toxic ones in use as mercury cadmium telluride the second has recently been proposed as a weyl semimetalthe fabrication of these materials as epitaxial thin films will enable the development of devices based on them bringing us forward to greener electronics and creating scientific knowledge on new materials and their properties that could lead to many more applications
neuromodulation of episodic memory how stress influences time in memory and perception

recent european data shows that stress shortens life expectancy by 28 years critically it also affects the way we sense and remember everyday life time presents a novel approach to a fundamental question in neuroscience how stress affects our memory and perception of experience over time previous research disregarded the role of specific neuromodulators studied stress effects selectively for a certain memory stage and used isolated stimuli rather than complex events in naturalistic contexts moreover stress effects on memory have never been linked to time perception during a stressful experience time addresses these critical gaps with an innovative combination of functional magnetic resonance fmri a pharmacological manipulation and a novel experimental paradigm in virtual reality vr the project aims at building the first comprehensive model of stress effects on memory of events and perception of time first we hypothesize that a stress hormone cortisol released across all memory stages encoding consolidation retrieval affects our ability to separate overlapping episodes and segment our experience into events wp1wp2 second we hypothesize that a higher sampling rate of sensory input may result in a distorted sense of time and influence subsequent temporal memory wp3 involved mechanisms will be measured and verified at the behavioural physiological wp1wp2wp3 neural wp2 and perceptual wp3 level i will carry out the research at cisa geneva outgoing phase supervised by prof rimmele prof vuilleumier and sissa trieste return phase supervised by prof bueti with short visits at columbia university nyc prof davachi together these worldleading centers offer a unique environment to make the project realistically achievable by bridging the gaps between neuropharmacology neuroscience psychophysics and psychophysiology time will move basic and applied science forward boost my academic or nonacademic career prospects
impact of cell shapes on cell behaviour and fate

cells are often depicted as irregular spherical objects the shape they adopt in suspension however the packed environment of tissues alters this simple shape causing large cell deformations this occurs during normal tissue growth and is even more pronounced upon tissue overgrowth as in the case of solid tumors cell shape changes frequently occur in migratory cells such as immune cells that patrol the organism within interstitial tissues and cancer metastases that escape from the primary tumor to invade healthy tissues in all cases cells adapt and survive even to very large deformations the mechanisms underlying such response and the longterm consequences that repeated cell shape changes have on physiology and pathology remain largely unknown we have observed that changes in the shape of cells and organelles induce reversible and irreversible modifications in their behaviour and functions we hypothesize that cells use such mechanisms to integrate the successive deformations of distinct amplitudes and durations that they experience during their lifetime this implies the existence of shapeinduced memory effects that not only encode the geometrical and mechanical history of the cell but also dictate its fate here we propose to tackle the molecular mechanisms and physical principles accounting for shapeinduced memory effects and to evaluate their impact on immunity and cancer we will focus on two cell types that undergo large shape changes in vivo and communicate to establish cancer immunity 1 dendritic cells which initiate adaptive immune responses and 2 cancer cells derived from mammary epithelia our project will reveal whether boundary conditions imposed by physical confinement are overarching determinants of cellular behaviours at different spatial and temporal scales and may further establish novel clinical paths for a holistic understanding of early malignancies and their recognition by the immune system
flexibly adapted metainnovations use cases collaborative business and governance models to accelerate deployment of smart and shared zero emission mobility for passengers and freight

metaccaze accelerates the usercentred deployment of smart systems and services that combine electric automated and connected mobility and related infrastructure across european cities metaccaze organizes a series of metadesign activities with multisectorstakeholders and different population groups to develop metadesigned shared zeroemission mobility use cases collaborative business and governance models a toolkit called metainnovations is developed consisting of six main smart technologies 1 align grid supplyfleetdemand 2 harmonise aidatawarehouse 3 charge inductive automated charging 4 automate i remote control center ii advanced driver assistance system iii 5 connect v2x protocols 6 manage operate i electric vehicle scheduling and demand 6 digital twin optimisation metainnovations are pioneered in passenger and freight services public transport ondemand mini buses bike sharing deliveries and related infrastructure mobility and logistics hubs traffic management centres charging infrastructure and widely demonstrated in 4 trailblazer cities amsterdam munich limassol tampere successful use cases metainnovations and metaservices are transferred implemented and demonstrated in 6 follower cities athens krakow gonzo milan miskolc paris region demonstrations are monitored to ensure that their impact aligns with the mission and sumpsulp targets and that the society embrace them the metaskills hub is developed and utilizes the lessons learned to deliver a series of crosssectorial interactive training courses the metapolicy package is developed to contribute to updates of urban and transport policies and feed the strategic research and innovation agendas sria of ccam 2zero and other initiatives metaccaze is a project and an initiative to transition cities to the green metamobility era that the green deal 2zero ccam mission and other eu partnerships envisage by 2030 and beyond
black hole spin and mass function in gaseous protoclusters

gravitationalwave gw astronomy opened a new window to the universe from its infant state to the present the key physical systems which allow probing the universe through these vast time and length scales are black holes bh low metallicity clouds composed primarily of atomic hydrogen before and during the epoch of reionization are a natural environment for bhs to be born and form binary black holes bbh which can merge via gw emission stellar bhs being the remnants of the death of very massive stars are generated early when a huge gas reservoir is available for accretion mass segregation leads the bhs close to the center of the system and a dense bhsubcluster supported by gravitational fluctuations is formed the low metallicity of the gas suppresses cooling while turbulence of the gas and the bhs motion further favor quasispherical accretion surpassing the eddington limit for sufficiently compact configurations the bhs shall grow in mass before the gas is depleted by stellar evolution and formation feedback processes this rapid mass growth through turbulent hot accretion shall leave a distinct spin signature on the bhs the bbh that accrete gas quasispherically may harden if there is not significant angular momentum loss from the system furthermore these are also ideal conditions for highredshift intermediate mass black holes imbh to form we shall calculate the spin distribution of stellar bhs accreting gas in protoclusters calculate the bh mass function following such accretion events investigate the evolution of separation in accreting bbh in lowmetallicity hot turbulent gas develop theoretical models for the evolution of a bhsubcluster inside protoclusters and investigate the formation of imbh finally we shall develop methods for identifying the origin of gw observations confront our results with ligovirgokagra data and investigate synergetically the implications for the gw mission lisa and the xray mission athena
the history of feminist political thought and womens rights discourses in east central europe 1929 2001

this project will produce the first comprehensive and multidisciplinary history of feminist political thought and womens rights discourses in east central europe in a broad chronological perspective the project builds on a solid base of existing scholarship but does more than weave the stories of individual women or fragmented national case studies in the existing scholarship into a coherent narrative instead it reinterprets the story of feminism in the region in relation to state socialism and the history of state socialism through the lens of feminism it treats the interwar prehistory of debates between socialism and feminism as well as the post1989 struggles to deal with the state socialist past as integral parts of the history of state socialism intellectual historians have paid relatively little attention to this region to women and to feminism yet it is precisely the issues traditionally at the heart of their field such as the origins and transformations of ideas in their social and cultural contexts that are required to understand feminism in east central europe recent advances in the field have often been driven by methodological innovations and particularly the use of sources beyond political essays and academic publications this project also draws upon sources like popular womens magazines literary and art works samizdat publications party documents and oral history interviews the research team reflects the diversity of the european continent mobilising linguistic and methodological skills to match the projects broad source base inclusive geography and extended chronology and to produce a body of research that is both comprehensive in scope and sensitive to local particularities by situating them in their local regional and transnational contexts this project integrates feminist political thought womens rights discourses and their authors in east central europe into the broader european intellectual tradition
ensuring secure and safe cmd design with zero trust principles

aligned with the guidelines of the cybersecurity act and the existing guidance on cybersecurity for medical devices entrust envisions a trust management architecture intended to dynamically and holistically manage the lifecycle of connected medical devices strengthening trust and privacy in the entire medical ecosystem even from the proposal stage entrust has identified gaps and necessary revisions of the current guidance eg absence of postmarket conformity and certification realtime surveillance and corrective mechanisms see 122 towards that entrust will leverage a series of breakthrough solutions to enhance assurance without limiting the applicability of connected medical devices by enclosing to them cybersecurity features the project will introduce a novel remote attestation mechanism to ensure the devices correct operation at runtime regardless of its computational power will be efficient enough to run in also resourceconstrained realtime systems such as the medical devices this will be accompanied by dynamic trust assessment models capable of identifying the required level of trustworthiness rtl per device and function service that will then be verified through a new breed of efficient attestation mechanisms to be deployed and executed during runtime this will also enable us to be aligned with the existing standards on defining appropriate protection profiles per device especially considering the heterogeneous types of medical devices provided by different vendors with different requirements including targets of validation properties to be attested during runtime the motivation behind entrust is to ensure endtoend trust management of medical devices including formally verified trust models risk assessment process secure lifecycle procedures security policies technical recommendations and the firstever realtime conformity certificates to safeguard connected medical devices
targeting cancer with mutanome based stem cell vaccine

the successful application of immune checkpoints inhibitors has modified the therapeutic strategies in several cancers but only 30 of patients will respond optimally to these therapies one of the reasons for the failure of these therapies is the resistance of cancer stem cells cscs leading to relapses long after the initial treatment these cells are also resistant to conventional therapies via their quiescence and there are no targeted therapies available against them the ambition of ipsirius a french biotechnology company spinoff of inserm and paris saclay university is to develop active cancer immunotherapy products based on the revolutionary induced pluripotent stem cell ipsc technology ipsirius developed first ipvac with the aim of leveraging patients immune system against a large panel of cancer antigens which are shared between ipsc and cscs with ipvac ipsirius is developing a groundbreaking technology having resolved all technical issues limiting cellbased therapies used for cancer ipvac is a safe allogenic offtheshelf therapy highly scalable using a versatile technology this cellbased vaccination strategy showed efficacy in prophylactic and therapeutic settings against aggressive solid cancers with stemness features the overall goal of the mutavac project is i to uncover the mechanisms of action of ipvac ii to generate a highly immunogenic version of ipvac and iii to design robust in vitro immunogenicity tests to predict immunogenicity of ipvac and ipvacmut in humans with mutavac project ipsirius will i strengthen the scientific data on ipvac to prepare its clinical development and leading to the open access publications and patents ii define a personalised medicine to propose efficient therapeutic cancer vaccine in patients with all hla groups iii identify new targets for future cancer therapies and iv develop a technological platform to facilitate the development of the nextgeneration of cell therapies
conservation and demolition of architectural heritage in times of transformation politics of memory versus politics of professionalization

for societies undergoing profound transformations the architectural heritage of the recent denounced past is central to both urban planning and political campaigning i will explore how after regime change the fate of such heritage monuments signature buildings and other sites perceived as cultural products and symbols of the ousted regime is justified debated and contested among the political establishment and the professional society of architects i argue that while the former groups decisions on heritage conveyed memory politics architects engaged with the issue driven by politics of professionalization ie a pursuit for expert agency and public recognition looking into the confrontations and dialogues between and among politicians and architects i highlight nationalist or civic values attached to architectural heritage and the inclusive or exclusive dimensions in its conceptualization my research condem focuses on sofia and plovdiv bulgarias two largest cities and three periods of political transformation nationstate building after 1878 state socialism after wwii and liberal democracy after 1989located at the intersection of three research fields urban history memory studies and critical heritage studies this is an interdisciplinary project combining historical and sociological methods i will trace the evolution of the problem of heritage in legal documents political papers and architectural critique over more than a century and conduct discourse analysis of heritage debates on the basis of identified case studies for their selection i employ four categories of events that triggered intensification of the heritage debate urbanist corporate heritagization and mnemonic by investigating how the meaning of architectural heritage changed over time reflecting competing political interests i aim to address the bigger question to what extent public representations of the past promote plurality or entrench discrimination