Dragon09/odtu_chatbot huggingface dataset:
modern numerical methods for highfidelity simulation of geohazards

geohazards such as rock avalanches landslides and debris flows are commonly recoganized as the slowtorapid gravitationallydriven processes that typically occur in mountain regions such as alps in europe himalaya in asia rocky in north americas and snowy in australia possessing potential hazards societies with the advancement of computer science numerical simulations of geohazards have become crucial in the modern geomechanics and geotechnical engineering the fragmentation of current research into local national projects often falls short in comprehensive understanding of the evolution mechanisms this gap results in a grey area in modern numerical methods for highfidelity simulations limiting accessibility for both scientific researchers and engineering practitioners monugeo brings together the complementary expertise of our consortium members to develop a better understanding of triggering initiation runout and deposition andor interaction with protective obstacles processes and in turn to produce the groundbreaking numerical tools for the highfidelity predictions our international and interdisciplinary consortium will also prefer to an integrated research approach involving laboratory experiments scaled centrifuge physics modelling tests and regionscale application with geological survey this integrated methodology will serve to validate our developed computing paradigms and numerical toolbox and to apply them to realistic scenario
era chair holder to establish the electron cryomicroscopy analysis of cellular and artificial nanomachines

hot4cryo aims to attract and maintain a prominent researcher era chair together with a highquality supporting team to advance multidisciplinary research in the national hellenic research foundation nhrf by founding the highresolution electron cryomicroscopy unit for excellence ie cryounite unique in greece the balkans and southeast europe while cryoem technology is transforming international research in exciting multiple directions substantial disparity exists in its possession across european countries and is absent in the complete southeast europe this hampers innovations in biomolecular and materials structure research and development and limits progress of eu missions cancer soil and green deal which align to the research directions of nhrf and the prospective era chair holder hot4cryo plans to address this issue aims to eliminate this disparity and envisions to urgently transmit the resolution revolution to greece and the wider region emerging as a cultural hub for seeding horizon europes strategic plan across players and the society cryounite will be embedded in nhrf enhancing institutional structural transformations hot4cryo will bring highend cryoem knowledge for a wide range of systems in alignment with era priorities the modern technology and innovation potential involved will undoubtedly progress digital transformation within nhrf improve research cohesion across all involved partners and foster fundamental and applied research opportunities of outstanding quality as a result of this action hot4cryo will produce a unit of excellence improve direct access to excellence for partners and collaborators and strengthen the interactions between science and society ultimately hot4cryo will contribute to reverting the current brain drain to brain gain while promoting brain circulation within the eu positively affecting local and regional economies
sustainable multifunctional and recyclable heat pumps

smartpumps aims 1 to optimally redesign heat pump components under the newly introduced design for additivehybrid manufacturing concept which apart from operational characteristics includes all lifecycle parameters such as recycled material sourcing and component recyclability for maximum efficiency sustainability safety and reliability 2 to utilize multiple materials which are mixed at different percentages in the various operational sections of heat pump components following the functional grading methodology thus fully exploiting their properties mechanical thermal electrical etc and maximizing material usage efficiency 3 to embed sensors and devices within heat pump components for monitoring and operational data extraction and also for actively changing heat pump component structure to optimize operation 4 to standardize testing and create manufacturing process and assembly protocols and 5 to create training curricula for all relevant stakeholder on digital design manufacturing and testing of smart heat pumps
advancing cooperation on asylum and migration

this proposal seeks to increase and reinforce the cooperation that has been initiated between the institute for central europe bratislava slovakia the university of lige and the university of paris in the field of migration and asylum governance this field of international relations is gaining increasing importance as the refugee crisis in 201416 became one of the key matters in european politics digging a deep divide between member states this divide being mirrored in social sciences the proposal seeks to foster a stronger mutual cooperation and understanding on these topics by formalizing cooperation between a young thinktank that intends to take a leadership role across v4 countries on these issues and two research centers that have developed a strong expertise on migration and asylumthe three partner institutions have all developed a specific field of expertise in relation to the topic of the proposal the institute for central europe ice focuses on policy issues that tend to play a decisive role in shaping the future of europe the university of liege uliege has developed a wide expertise on migration and asylum governance in europe the university of paris up has conducted a number of studies on the health of migrants and the representation of migration in public opinion the key objective of this proposal is to bring these areas of expertise together to create a comprehensive and consistent cluster of research activities this cluster will allow for a better understanding of the mutual perceptions and policies on migration and asylum in particular the partnership will seek to achieve the following objectives 1 develop joint research activities events and projects pertaining to migration and asylum 2 foster cooperation and exchanges of researchers and staff between the three partners as well as with other international noneu partners3 reinforce the research and capacities of the partners 4 inform public debates
diamonds as the key to unravel the origin of earths water

the origin earths water is still an unsolved mystery in earth sciences yet answering this question is paramount in order to validate planetary accretion models and determine the conditions for lifesustainable planets to form comparing earths original deuteriumtohydrogen ratio dh with those of solar system objects such as meteorites comets and the solar nebula can constrain on the provenance of water however while dh is precisely determined for extraterrestrial objects the exact value for earth is not known due to the fact that earths primordial dh got lost since its formation following surface and mantle geological processes in fact current estimates from mantlederived lavas are challenged by the ability of these samples to retain pristine values indicating the need for a pristine reservoir that remained unaffected over geological time to be found diamonds from the earths mantle may be key as they contain trace amounts of hydrogen and are inert and robust time capsules able to survive over several billion years the overarching goal of this project is to determine earths primordial dh by investigating the hydrogen content and isotopic composition of a unique set of worldwide natural diamonds dating 35 to 009 billion years ago using newlydeveloped highprecision and highefficiency isotope ratio mass spectrometry the isotopic data will be complemented by atomistic stateoftheart ab initio simulations to understand the atomic and diffusion behaviour of hydrogen in natural diamonds the new results will be fundamental to pinpoint earths water origin with longterm implications for understanding planet habitability in a time where international space agencies are actively searching for potentially habitable planets and extraterrestrial life the new knowledge will be fundamental to understanding the geological and biological evolution of planets in our solar system and beyond
manyantibodies

many of the exceptional breakthroughs in pharmaceutics require the collective and interdisciplinary effort of the scientific community to overcome challenges and shortcomings involved in optimizing the formulation of the final product monoclonal antibodies for instance have been found to be highly effective for the treatment of various immunological and allergic diseases as well as for cancer treatments thanks to their high specificity on the other hand they typically present high viscosities in concentrated solutions dramatically altering their flow properties the direct consequence is the difficulty in preparing stable solutions suitable for subcutaneous selfadministration which compared to intravenous infusion would be advantageous in terms of patient compliance and adherence to the treatment and reduced healthcare costs currently a univocal framework providing microscopic interpretation to the enhanced viscosity is missing with my proposal manyantibodies i aim to address this issue by putting forward an interdisciplinary approach which exploits soft matter and colloidal science to investigate the molecular origin of the observed macroscopic behavior in antibody solutions by combining numerical simulations with experiments i will first design an accurate singlemolecule model that accounts for the anisotropic shape of the antibody and include all relevant ingredients that determine intermolecular interactions therefore through advanced computational techniques i will be able to bring the current understanding of the antibody collective behavior and rheological properties to a new level by shedding light on their dynamics and selfassociation in crowded environments with the direct collaboration of pharmaceutical industries my proposal will ultimately guide the formulation of novel antibodybased biologics and inspire future studies where the features of the antibody are designed according to the desired solution properties
rnabased gene writing in human cells

crispr development has enormously accelerated genetic engineering principles and precise methods to modify small alleles such as base or prime editing are now available however generating large genomic changes still presents enormous challenges large modifications such as gene transfers are performed generally with viral vectors which have been associated with toxicities in the clinic and often lack versatility needed for basic science experimentation newer crisprbased techniques for gene transfer suffer from significant efficacy and safety problems when used for large message writingthe overall goal of scribe is to create new strategies for gene writing and define their molecular principles these new writers will use rna to both encode and transfer the message the scribe strategies will take advantage of the retrotransposon capacity for writing genes from rna and the precision of crispr in addressing specific sites of the genome thus the find function will be dominated by crispr components and copypaste activity will be executed by retroelement components to develop and optimize such a technology we will use evolutionary analysis to select those retroelements with the highest activity and orthogonality and modulate their message writing capacity by engineering their components we will test various crispr and retrotransposon combinations and adapt both of them to converge into a unified molecular machine we will use artificial intelligence applied to protein design and a novel concept of synthetically oriented evolution to accelerate emergence of the new function finally we will deploy new gene writing principles for rnabased in vivo gene deliveryin sum we will develop a new family of tools for engineering life the real breakthrough will be the establishment of gene writing as a simple and general method for both research advancement and applied purposes
detection and elimination of senescent cells targeting cyclophilin d

ageingrelated diseases are tightly correlated with the accumulation of senescent cells while the selective elimination of senescent cells is a primary therapeutical goal in the field no clinically approved treatment currently exists which constitutes an important research gap abundant evidence highlights how changes in mitochondria and cellular metabolism can be both cause and consequence of the senescent phenotype and suggests a possible role of this organelle in the specific targeting of these cells through a crisprcas9based screening serranos laboratory identified cyclophilin d cypd as a promising candidate target since its inactivation leads to the selective elimination of senescent cells while being nontoxic for control proliferating cells cypd is a matrix isomerase involved in various mitochondrial functions including the regulation of cell death and the opening of the mitochondrial permeability transition pore a nonspecific pore in the inner mitochondrial membrane by sensitising it to calcium and reactive oxygen species interestingly additional functions have been described for cypd including proteins scaffolding as it binds to several mitochondrial proteins apoptosis and mitophagy control and regulation of the electron transport chain activity this project will study cypd as a novel noninvasive senolytic target and provide a molecular understanding of its modulation in senescence biology taking advantage of the various wellestablished senescence models developed in serranos laboratory including human and mouse cells and in vivo models the ultimate goal is to improve the therapeutic outcome of senescenceassociated diseases by developing new strategies for the detection and elimination of senescent cells in patients
gene environment interactions in mental health trajectories of youth

youth mental health is heavily burdened with lifelong enduring impact on european citizens and societies trajectories of mental health and illness in young people are assumed to be determined by interplay between genetic epigenetic and environmental risk impacting during development however direct evidence for this is sparse and scientific progress is challenged we recently initiated substantial advances enabling us to create necessary breakthroughs at the most pressing needs and challenges aiming to significantly reduce mental suffering and illness among european youth within the next 510 years we will provide 1 the worlds first evidencebased knowledge base of functional epigenomics of the developing postnatal human brain in direct relation to developmental trajectories of transsyndromal phenotypes of mental illness providing improved risk markers and actionable biological targets 2 reliable predictive models while identifying geneenvironment interplay as well as actionable markers of trajectories of mental illhealth in young people through the use of artificial intelligence aibased and inferencebased analyses of unprecedented sets of longitudinal general population datasets 3 the first comprehensive validated set of evidencebased behavioural environmental biological and psychologicalinformed instruments for the robust quantitative clinical assessment of mental health for helpseeking young people aged 1224 years harmonised across european clinical settings and 4 youth and clinicianempowering aidriven instruments for early selfdetection prediction and monitoring of mental illhealth trajectories in youth our multidisciplinary consortium is uniquely equipped and positioned to enforce the necessary breakthroughs for significant reduction of mental illness and suffering of young people and to translate our findings into clinical innovation and lifelong impact in europe and beyond
metabolic gut inflammation in crohns disease

the rising incidence of inflammatory bowel diseases such as crohns disease cd has become a global health care issue in the 21st century the complex genetic underpinning is increasingly appreciated while environmental cues and specifically a western diet are suspected to impact development and course of disease mechanistic insights that would support this assumption remain scarce and specific nutrients that trigger a flare are unknown westernisation of dietary habits is partly characterised by enrichment of longchain fatty acids which fuel metabolic inflammation of tissues beyond the gut here we propose to establish the concept of metabolic gut inflammation as a fuel for cd by analysing transgenic mice human cd organoids and two independent cd patient cohorts we seek to establish how dietary polyunsaturated fatty acids pufas affect gut inflammation and disease course the proposed work is based on our previous observations that dietary pufas trigger a chemokine response and crohnslike enteritis in mice which is restricted by intestinal epithelial glutathione peroxidase 4 gpx4 gpx4 is an evolutionary conserved antioxidative enzyme which shows impaired activity in cd epithelium the proposed work will identify how dietary pufas elicit gut inflammation in mice and which epithelial lineage executes the inflammatory response in a next step i propose to establish a critical crosstalk between gpx4 and metabolic hubs in gut epithelium to provide a basis for the concept of metabolic gut inflammation finally we seek to translate findings by establishing that pufas evoke an inflammatory response from cd epithelium and that pufa intake impacts disease course megi cd comprehends basic and translational science to set the basis for novel therapeutic strategies in a complex illness that requires better treatment modalities the study will prove the concept of metabolic gut inflammation as a major driver of human cd a basis for nutritional therapy
bioinspired living skin for architecture

biofilms an assemblage of surfaceassociated microbial cells that is enclosed in an extracellular polymeric substance matrix are recognised as one of the most stable biological systems on earth the beneficial use of biofilms for protection is nearly unexplored since uptodate research is focused on the prevention of its formation in the archiskin project we will explore the design principles underlying fungal biofilm to bridge the knowledge gap on the chemistrystructureproperties of the biological systems interface mechanisms of biofilm formation its structure function quorum sensing and performance will be understood at multiple scales following the best practices of materiomics it will be achieved by advancing stateoftheart insitu laboratory routines and use the latest mathware solutions in combination with the designbuildtestlearn approach for the experimental work in the following step we will develop a bioactive protective coating system working in conjunction with nature we will benefit from the synergic strength of living fungal cells biobased ingredients and bioinspired concepts for materials protection advanced insilico methods will be used for the integration of active ingredients and modelling of optimal and longlasting nutrient sources compatible with the enzymatic profile of selected fungal strains we will design and create technically applicable controlled and optimized biofilm built by the yeastlike ubiquitous and widespread oligotroph fungus aureobasidium pullulans that will effectively protect the surfaces of biomaterials concrete plastics and metals among others assuring optimal service life performance and remarkable functionalities including selfhealing and bioremediation our pioneering approach for materials protection will push the boundaries of traditional materials concepts toward the development of engineered living materials capable to interact adapt and respond to environmental changes
marine annelids as a model for disentangling the molecular basis underlying the evolution of reproductive strategies and reproductive timing

alternative developmental and reproductive programs provide powerful sources of adaptive variation which greatly enhances survival in changing environments yet how divergent reproductive strategies and traits evolve remains poorly investigated particularly in the ocean where the dramatic effects of climate change and anthropogenic impact on reproductive dynamics threaten entire animal communities for this i plan to close this knowledge gap by investigating the molecular and genomic basis underlying the divergent reproductive strategies and reproductive timing in platynereis marine bristleworms these animals are easy to breed in laboratory conditions are geneticallyaccessible and display a kaleidoscopic diversity of reproductive traits in closelyrelated species specifically i plan to 1 dissect the molecular mechanisms of the drastically divergent reproductive strategies of the sister species p dumerilii and p massiliensis and 2 decode the genomic basis of alternative lunar reproductive periodicity in platynereis species thus i will combine my experience in working on the reproduction and chronobiology of these models with evolutionary genetics population and comparative genomics functional genomics and transcriptomics strategies mastered in the host lab on one hand i will provide groundbreaking insights on how molecular machinery can be drastically rewired generating novel and adaptive combinations of reproductive traits on the other i will shed light on the elusive molecular nature of lunar reproductive periodicity a widespread phenomenon particularly in the marine environment and its evolution currently endocrine disruption and light pollution are severely affecting animal sexual development and reproductive timing respectively challenging the conservation of entire ecosystems in this context this research will also provide fundamental resources to better understand their effects on the marine environment
flexiform structurally and materially informed design and fabrication strategies for knitted textile formworks for concrete structures

the flexiform project is set to transform the construction industry by substantially reducing material usage and embodied carbon in new buildings through an innovative design and construction approach for concrete structures by leveraging the structural and material efficiency of doublecurved geometries and lightweight 3d knitted textile formworks the project seeks to create sustainable costeffective and reliable structural solutions to achieve this challenging goal the project will develop a unified computational design and fabrication workflow that optimizes material usage and accurately predicts the mechanical properties of knitted textiles by incorporating knitted textiles material and fabrication constraints into the workflow the project will reduce reliance on specialized knowledge and physical testing moreover the flexiform project will establish an opensource material database and a formfinding method for knitted textile formworks that will facilitate the widespread adoption of sustainable practices in the construction industry ultimately the projects outcomes will contribute to the objectives of the european green deal and the new european bauhaus promoting transparency collaboration and dissemination of research findings through reducing raw material consumption and introducing innovative construction techniques the flexiform project will pave the way for a more sustainable and efficient future in the construction industry