Dragon09/odtu_chatbot huggingface dataset:
building multidisciplinary evidence to support integrating malaria vaccine with seasonal malaria chemoprevention in west africa

despite available efficacy data on two malaria vaccines designed for broad use there is little evidence about scalable delivery strategies in areas with seasonal malaria transmission we propose a multisite multidisciplinary phase iv clusterrandomized trial in burkina faso and mali to evaluate the effectiveness reallife impact acceptability feasibility and costeffectiveness of a novel integrated delivery strategy of r21matrixm in areas with highly seasonal malaria transmissionwe will compare campaignstyle vaccination coadministered during seasonal malaria chemoprevention to vaccination following an agebased strategy in routine essential programme on immunisation activities using a noninferiority design we will engage with all stakeholders to codesign the integrated strategy collect malaria incidence data via surveillance and prevalence via crosssectional surveys generate data on coverage assess feasibility and acceptability among stakeholders and endusers using qualitative longitudinal study methods and describe the costeffectiveness of both approaches with costs and outcomes measured from the societal perspective we will also use the trial platform to perform postlicensure pharmacovigilance of r21matrixm the project will ensure translation of results into policy and practice throughout areas of highly seasonal malaria transmission it responds to sdg3 and is aligned with the immunization agenda 2030 particularly by testing a communitybased vaccine approach that should reduce the number of zerodose children by leveraging the smc platform we hope to mitigate vaccine hesitancy our multidisciplinary approach aims to generate a comprehensive package of evidence that will allow policymakers to make informed guidelines for malaria vaccine schedules and delivery in the sahel at the same time reinforcing health systems and promoting synergies between malaria and vaccination programs in support of the primary health care agenda
exploring active edible materials based on phenolicbioconjugates from agroindustrial byproducts for sustainable and healthy future food packaging

activeedible materials applied in food packaging have great potential as a sustainable strategy for maintaining food quality they act as a barrier to the outside environment and a vehicle for active compounds that can extend the shelflife of food products agroindustrial byproducts represent a valuable source of active and functional compounds for packaging development with great accessibility and low prices while decreasing reliance on fossil resources among the compounds present in agroindustrial byproducts phenoliccarbohydrates bioconjugates have attracted a lot of attention in the last years due to their bioactive properties as antioxidant and prebiotic which can promote a positive influence on human health however their application on the development of active edible materials for food packaging remains poorly explored echos project proposes an innovative approach using phenoliccarbohydrates bioconjugates in the design of edible packaging with improved performance combining the mentioned bioactivity with functional properties to form selfstanding films and coatings two biorefinery approaches will be developed in the present study to add value to relevant agroindustrial biomasses 1 the recovery of natural bioconjugates by green extraction techniques and 2 the enzymatic crosslink of phenolicrich fraction and exogenous carbohydrates a comparative study will be conducted on the feasibility and sustainability of using natural and biomimetic bioconjugates as active packaging materials the bioactivity of the materials will be continuously assessed on fresh food preservation along with the health benefits associated with their intake eg prebiotic effects on gut microbiota the echos project will lead to an important advance in the use of phenolicbioconjugates as building blocks in the future food packaging market aligned with the objectives of the european green deal initiative
cheops very highpower building blocks

for the future of space exploration and space logistics and to reduce costs for orbit transportation of future payloads very highpower hall effect thrusters of 20 kw or above are at the forefront of several initiatives today be it as single or clustered units the combined thrust of these electric propulsion systems eps paves the way to allowing larger spacecraft and more ambitious missions to be envisaged however given that these missions would require significant burn time of the eps several important issues must be addressed that go beyond the simple ability of manufacturing larger eps components specifically qualifying such electric thrusters for lifetime is currently a showstopperin the race to the moon and mars as well as other lucrative commercial missions within earths orbit beyond 2030 the european space industry must catch up with the us studies within europe have already been initiated for the incremental development of 20kw class hall thrusters such as the fp7 hiper project which produced the pps20k ml thruster up to trl4 fp7 cheops project which permitted sitael to develop their 20kw het esa projects allowing unipi to develop their nested multichannel tandem thruster or the ongoing h2020 aspire project led by sitael nevertheless given the challenges and the opportunities that vhp present research such as proposed in cheopsvhpbb must be anticipated now ahead of its effective deployment in 203040 project activities will complement ongoing thrusterfocused development activities with research and development on key building blocks essential for the future use of vhp hall thruster systems overall system architecture against various mission use cases robust and costeffective approach to qualification using probabilistic failure analysis manufacturability of key components subject to wear notably the discharge chamber and cathode and the ability to envisage alternative propellants and power sources for future missions
gemseeachro genomic explorationmapping the spread evolution and adaptation of an emerging bacterial pathogenachromobacter

achromobacter species are rapidly emerging gramnegative opportunistic bacteria intrinsically resistant to several antibiotics and are often the cause of healthcareassociated infections especially in individuals with compromised immune systems or underlying conditions following years of misclassification of achromobacter spp isolates combined with complicated species typing the understanding of the ecology of achromobacter spp and their clinical significance is lacking gemseeachro aims to answer the questions regarding the population structure evolution adaptation antibiotic resistance development and genetic variability of achromobacter spp both globally and locally providing crucial insights into the factors contributing to their prevalence antimicrobial resistance patterns and potential novel therapy approaches analysis of whole genome sequencing wgs data allows to disentangle these questions therefore i propose the largest achromobacter spp study to date including over 800 wgs encompassing its global diversity sampled from both the environment and infected patients employment of a number of bioinformatics analysis methodsgene content difference analysis single nucleotide variant and mobile genomic element identification and association with population structure evolutionary and migration rates analysis using bayesian phylogenetics and resistance phenotype association with genomic differenceswill help to answer the fundamental questions of how these bacteria evolve and adapt to their environment what are the main differences in genetic composition between the environmental and clinical samples and how these differences can inform us about the population structure and antibiotic resistance development in achromobacter spp the gained knowledge could be generalised and applied to studies of other less studied bacterial pathogens
integrated modelling for sustainable and optimized steel manufacturing processes

proctwin aims to develop a demonstration platform to predict and visualize best use of multiple processing steps in a steel manufacturing chain the methodology includes intelligent coupling of interconnected processing steps by numerical simulation soft sensors process data and distributed machine learning integrated numerical modelling that captures the interactions relations and feedback loops between various processing stations enables prediction for smart optimization of energy efficiency and product quality in the steel manufacturing continuous casting reheating hot metal working quenching and leveling processes are examples that are controlled separately but strongly interconnected in terms of parameters these processes serve as objective functions in two parallel use cases at celsa es and ssab sw it is well known that process optimization can have a significant effect on reducing carbon footprint in steel production and implementing new digital tools will enable a faster transition towards sustainable industry proctwin is divided in clear work packages to reach the objectives one is adaption of existing physically based numerical models of each process step to generate critical data that is impossible to measure or observe another is development of novel sensors and data integration for a secure and effective sharing industrial data the innovative concept of proctwin is development of distributed machine learning to predict the process chains with large amounts of parameters lastly these technologies will be combined through a demonstrator platform to model the manufacturing processes and enable control for increased product quality energy efficiency and operator support
intercultural and transcultural competence through collaborative cultural expression

amidst the unprecedented speed and scale of forced migration and climate mobility in europe arts in education has a significant role in promoting social inclusion diversity and cohesion critically exploring cultural hierarchies divisions and exclusions within arts and education intracomp develops methods digital resources and frameworks for advancing intercultural and transcultural competence itc in lifelong learning in cultural awareness and expression aligned with neb itc inspires together and beautiful through collaborations on innovative meaningful complex and temporary expressions of culture and enables arts learners to continually transform paradigms and social behaviours intracomp empowers this disposition and capability through the research and innovation of a viable competence framework for individuals groups organisations and systems that identifies evidences evaluates and scaffolds itc in performing arts education from ece to tertiary and community contexts to achieve this the transdisciplinary intracomp consortium explores itc within diverse societal locations in northern southern and eastern europe through partners situated in cultural organisations and tertiary institutions in norway belgium germany finland italy the uk serbia slovakia greece and hungary intracomp partners in new zealand and papua new guinea provide further opportunities to extend these education and community arts interventions in the global south questioning eurocentric assumptions regarding itc acculturative stress and arts in education the resulting itc framework provides learners teachers groups and organisations with a common reference point for itc and its complex internal dimensions and proficiency levels through this integrated and multipronged approach arts in education will enhance the inclusion and itc of all children and young people in europe and beyond
education for responsible democratic citizenship

eusociety faces four major challenges the anthropocene crisis digitalisation the pandemic and the ukraine war and its consequences all these challenges put at risk the model of liberal democracy which of course has faced similarly internal threats eg political polarisation right wing extremism mistrust in scientific research and conspirational beliefs and external critique questioning whether plural democracy is the best model to affront societal challenges education and especially education for democracy efd shall contribute to the defence and enhancement of democracy this includes the values and principles encompassed within the uns 2030 agenda and its sustainable development goals goal 47 in particular defines that education should promote sustainable lifestyles human rights gender equality promotion of a culture of peace and nonviolence global citizenship and appreciation of cultural diversity to reinforce the resilience and sustainability of democracy democrat aims through a participatory approach to elaborate curricula for efd based on a framework of responsible democratic competences rdcs to test them in open local innovative learning projects and to develop a toolbox to support the development of transformative efd practices in the eu and beyond democrats ambitious research and innovation programme will provide insights into the points of comparison and contrast in efd in the eumember states and will develop an innovative curriculum framework linking rdcs with digitalisation and sustainability democrat will test and analyse pedagogical practices and material considering its effectiveness for acquiring democratic competences and european identity it will garner insights into the factors influencing the impact of efd on public participation through the analysis of european datasets with a particular focus on the relation between socioeconomic and educational inequalities and political and social participation
backscattering coherent stokes raman scattering scissors for realtime cancer diagnostics

the goldstandard for cancer diagnosis is the pathological examination of hematoxylin eosin he stained tissue though well adopted worldwide for the coloration of large numbers of cancer sections the classical hestaining procedure is unable to provide a fastfeedback to surgeons within less than 30min this latency compromises the efficiency and accuracy of any tumor resection with numerous negative impacts for the success of the surgery and patients health prospect recently the chemicalbondspecific image contrast provided by stimulated raman scattering srs was shown to be suitable for the generation of helike images however the srs signal fundamentally propagates forward and is absorbed in thick biopsies rending a srsbased diagnosis impossible furthermore the srs imaging speed is still too slow for the realtime determination of cancer borders in large specimenhere i want to resolve these obstacles by combining the nonlinear optical contrast coherent stokes raman scattering csrs with high illumination angles csrs will permit for the helike image generation but will direct the signal photons into the backward direction as a result of a unique momentum conservation law backward csrs will allow for the investigation of thick cancer samples and will enable technical solutions to boost the imaging speed that were never an option before thus the development of csrs is not only a scientific breakthrough that circumvents the fundamental dogma of always forward scattered light but will provide helike images of thick samples as a realtime feedback to improve the success rate and timeefficiency of cancer surgery
establishment of a network providing improved professionalised services and support to euratom national contact points and programme applicants

neteuratom is the network of euratom national contact points with an overall concept to establish a united learning network of ncps undertaking transnational activities for a more consistent level of ncp services resulting in higher quality of submitted proposals from applicants more specifically the project aims to provide improved and professionalised services to all euratom ncps simplifying access to euratom calls in nuclear research and trainings and lowering entry barriers for newcomers through knowledge sharing and skills development particularly for newcomers and less experienced ncps trainings and mentoring activities regarding euratom programme applicants and other relevant stakeholders the project will provide information and training material needed in order to raise the average quality of proposals submitted as well as matchmaking activities with the scope to link up potential participants with emerging consortia in nuclear research neteuratom seeks to establish close collaboration with other horizon europe ncp and eu networks through joint organisation of matchmaking and training activities aiming to complement support services to applicants all project activities and outcomes will be promoted to all euratom ncps and the wider publicneteuratom will be implemented by a consortium of eight officially nominated ncp organisations from eight eu member states the project is a coordination and support action with a 60 month duration
autonomous drones for nature conservation missions

the aim of wilddrone is to push wildlife conservation practices into the 21st century the need for effective costefficient conservation practices are greater than ever as we currently face the greatest loss of global biodiversity in history present conservation practices are typically very labour intensive costly and timeconsuming collected data is often inaccurate or incomplete however recent advances in drone technology have shown that this technology has great potential as a practical tool for conservationists and that it could potentially revolutionize our efforts in nature conservation nevertheless drone technology is still a developing field and many obstacles stand in the way of us harvesting the benefits of this emerging technology to fully achieve its promising potential in this new domain we will need to invent more robust and predictable robotic technologies including effectiveand automated means of gathering and interpreting ecological and behavioural data wilddrone will address these challenges by joining the scientific areas of aerial robotics computer vision and wildlife ecology the network proposes to develop new autonomous drone technology expand current computer vision capabilities and combine these advances to create practical tools for visual inspection and monitoring of wildlife populations this dronebased inspection will provide conservationists with crucial knowledge of animal health behaviour and numbers these challenges will be solved by 13 phds three selffunded an interdisciplinary research training programme has been designed to educate a new generation of phds and provide them with a unique skill set enabling them to tackle the great challenges we must solve collectively if we are to reverse the decline of global biodiversity this program will raise the level of excellence in doctoral programs and simultaneously enhance the career perspectives of the phds in both academia and industry
a readytofly deorbit device based on electrodynamic tether technology

electrodynamic tethers are long conductors in orbit that enable spacecraft to deorbit andor reboost without using propellant after designing manufacturing and testing a prototype of a deorbit device dd in the fet etpack project and reach trl 4 etpackf faces the next natural step prepare a readytofly dd based on electrodynamic tether technology to perform immediately after the project an inorbitdemonstration iod the two large companies of the team sener aeroespacial and rfa playing the roles of dd product developer and enduser signed a launch service agreement for this first flight the dd involves several tetherrelated products that have by their own a high innovative and commercialization potential and are mainly ownedgenerated by the three universities of the team uc3m unipd tud these products are a software for tether mission analysis a heaterless electron emitter for electric propulsion applications a cold gas system miniaturized avionics and onboard software for the attitude determination and control of small spacecraft and a deployment mechanism and damper for tether applications in parallel with technology development activities a business model for etpackf technologies and consortium structures for their later commercialization a joint venture startup and or technology licensing will be created contact with potential clients investors and policymakers will be established to validate the business model and prepare the products for the future needs of the market this entrepreneurial ecosystem made of interlinked space products strong industryacademia collaboration and an end user is driven by the iod which can place all the products in a precommercial state tethers can help europe to createstrengthen new markets on space debris deorbiting and inorbit servicing disrupt the existing markets on spacecraft reboost and station keeping and open new opportunities for planetary explorations
new molecular and cellbased approaches to assess food astringency and bitterness

taste properties are vital to humans they impact human survival nutrition health and wellbeing the problem of unpleasant taste properties namely bitter or astringenttasting compounds is emerging in many diverse research fields beyond the obvious interest in food science nutrition and in the improvementselection of crops also human taste disorders and drug discovery domains could also benefit from research on astringency and bitterness crossing the boundaries among different fields betasty goes beyond the current stateoftheart of foodoriented researches to respond to the prominent challenges on astringency and bitterness this proposal will provide an indepth mechanistic and functional understanding into the main physicalchemical events triggering the physiological and neural perception of astringency by an innovative approach considering the main oral key pieces namely salivary proteins epithelia and emphasizing the role of mechanoreceptors on that sensation betasty will also unveil how for some compounds astringency and bitterness can go together by an innovative allinone model additionally the individual features that account for sensory differences will be deepened by a pioneering approach based on human organoids and electroencephalography the final goal will be the creation of cuttingedge cellfree biosensors based on the identified orally active mechano and bitter taste receptors to assess astringency and bitterness respectively and by overcoming the main drawbacks of the existing cellbased ones endowed with a truly differentiated and disruptive character this groundbreaking project will engage food chemistry biochemistry neuroscience sensory analysis and biotechnology fields of research to outdo the stateoftheart only an ambitious and multidisciplinary proposal will yield scientific breakthroughs on the biochemicalneuralperceptual triad events of these taste properties which will eventually enable to tailor them