Dragon09/odtu_chatbot huggingface dataset:
biodiversity abrupt ecosystem shifts and restoration understanding their links to sustain drylands under global change

global change and desertification drivers such as climate change and increased fire frequency make drylands more prone to abrupt shifts that can lead to the emergence of degraded states unable to provide key ecosystem services and to sustain life however we still lack an indepth understanding of the prevalence and triggers of these shifts and of the identity of those ecosystem attributes and services that are most affected across global drylands these uncertainties arise largely from the absence of global monitoring efforts and experiments investigating temporal changes in biodiversity and associated ecosystem services furthermore the lack of a systematic evaluation of the ecological impacts of restoration actions such as tree planting hampers our capacity to assess their usefulness to prevent abrupt ecosystem shifts and to combat climate change and desertification bioshift will combine globalscale experimentation and temporal field surveys with stateoftheart earth observation mathematical modelling omics approaches and statistical analyses to tackle these key knowledge gaps specifically i will i determine the prevalence drivers and consequences of abrupt ecosystem shifts in drylands ii assess whether in situ temporal changes in dryland biodiversity and ecosystem services exhibit thresholdlike responses along global aridity gradients and iii conduct the first systematic field assessment of the ecological impacts of tree plantations and their capacity to prevent abrupt ecosystem shifts in drylands worldwide by doing so bioshift will make a major leap forward in our understanding of abrupt ecosystem shifts and provide unprecedent insights on how to monitor and manage them this project will also provide the ecological underpinning to high profile international initiatives aimed at tackling biodiversity losses mitigating global change and desertification impacts and restoring degraded ecosystems across global drylands
excellence hub in green technologies introducing innovation ecosystems in the mediterranean food value chain

the excellence hub excel4med is an initiative to strengthen mediterranean innovation excellence in innovation ecosystems focusing on the production of nutritious food products and the valorization of food industrial sidestreams it is a crossborder collaboration between greece malta and france on a common strategy on strengthening the mediterranean food addedvalue chains excel4med innovation ecosystems will be interconnected with umbrella company organizations research institutions governmental bodies and societal actors that will be mutually reinforcing each other in a mediterranean context and together will raise the level of innovation excellence in their regional fabric
mechanisms of antibiotic recalcitrance in eskape pathogens

antimicrobial resistance amr is the silent pandemic uprising for the past decades that challenges practitioners to everyday life in this context more and more infections have become harder to treat even in absence of genetic markers for amr this phenomenon called recalcitrance is related to the ability of susceptible bacteria to overcome antibiotic treatment and to reinitiate infection contributing to antibiotic failures and resistance emergence previous studies have described the involvement of a phenotypic switch leading to recalcitrance but underlying mechanism remain poorly understood eskape standing for enterococcus faecium staphylococcus aureus klebsiella pneumoniae acinetobacter baumannii pseudomonas aeruginosa and enterobacter spp pathogens are the most prevalent causative agents in common recurrent healthcareassociated infections as well as wellknown for their multidrug resistant phenotype and are the best candidates to understand recalcitrance hereby we propose to investigate two of them e faecium efm and e cloacae complex ecc by studying the proteome involved in recalcitrance to identify any protein andor pathway of interest we will i identify which stress and bactericidal antibiotic induce recalcitrance both in efm and ecc ii evaluate proteome and phosphoproteome of isolated antibioticrecalcitrant bacteria and iii confirm functionality of candidate proteinspathways by mutagenesis and phenotypic approaches in vitro and in cellulo with the expertise of prof helaine at harvard medical school hms in boston secondment finding potential protein targets can highlight new candidates to further develop new therapies to overcome the rising of amr
identifying future capabilities for community policing

across europe society is changing due to demographic technological and economic developments communities are getting more diverse both in real life and online this challenges law enforcement agencies leas to engage with and to reassure communities about safety and security matters in a trustful waythe changing status quo is significantly shaping perceptions of policing requiring adaptive strategies to address these challenges the koban project will create an innovative research and practicebased community policing cp initiative adopting an evidenced based approachit will focus on cocreation and collaborative security between lea and nonlea community members leading to mutual trust and respecting each others contributions this results in a greater sense of security whilst contributing to an overall increase in the efficiency and effectiveness of securing all communities including those who are often considered hard to reach and engage kobans capability model will identify proven methodologies models technologies tools and best practices and use them as a foundation for future proactive coactive and reactive cp capabilities this knowledge will help to build the ai assistant as well as the app factory for the development of further cp tools methods and solutions tailored to the needs of stakeholders and adhering to social legal cultural ethical and gender equality standards these will be tested and validated in six pilot projects throughout europe koban will support capacity building embedding knowledge skills and capabilities within organisations and communities leading to bespoke training for both police personnel municipalities and citizensin short koban will lead a cultural and organisational transformation that address current fundamental barriers to effective community policing with its capability driven approach koban is setting the stage for futureproof community policing both online and in the real world
intelligent digital toolbox towards more sustainable and safer extraction of mineral resources

europes industry and economy depend on a secure access to many commodities in 2020 the ec updated its list of critical nonenergy nonagricultural raw materials crms based on scarcity of supply and importance to eu industry today the list includes antimony fluorspar magnesium silicon metal baryte gallium natural graphite tantalum bauxite germanium natural rubber titanium beryllium hafnium niobium vanadium bismuth hrees pgms tungsten borates indium phosphate rock strontium cobalt lithium phosphorus coking coal lrees scandiumsecuring sustainable access to crm is of high importance for the eu economy however the eu is confronted with a number of technological and environmental challenges along the entire production value chain of primary and secondary raw materials nethelix demonstrates in real life settings a toolbox of new technologies for automating and streamlining the extraction process taking advantage of deposits through mining and waste deposits processing methods maximising efficiency reducing waste production and increasing environmental and huma health and safety
spatiotemporal dynamics of immune circuitry in glioblastoma from single cells to comprehensive models of tumor niches

glioblastoma gbm is the most lethal brain malignancy in adults and is associated with a poor prognosis therapy options in gbm patients are largely limited by the highly immunosuppressive tumor microenvironment tme identifying and disrupting these immunosuppressive communication circuits between immune cells and the tumor is key to reinvigorate the immune systems ability to fight the tumor here we combine my previous experience in the analysis of single cell data at the neuroimmune interface with prof zeisers patientcentered expertise in developing novel therapy options to combat tumor immune escape in this highly complementary setting we propose a datadriven approach to trace and perturb inhibitory communication circuits elicited by the tme across space and time with the aim to discover novel immunotherapeutic targets in gbm using a novel temporal single cell technology we will 1 assemble a multilayered spatiotemporal single cell roadmap to characterize and model how individual immune cells are affected by the tme in a murine model of gbm 2 we will develop a computational framework for spatial transcriptomics to dissect single cells into niches defined by similar interaction programs with neighboring cells 3 using this tool we will quantify the niche organization in human patients and identify ligandreceptor interaction pairs crucial for niche maintenance 4 candidate genes will be genetically ablated in either the tumor or the immune compartment and evaluated with regards to their in vivo efficacy in suppressing tumor growth our cuttingedge analytical pipeline from the identification of driver molecules for immune escape to the assessment of in vivo efficacy in a preclinical model of gbm will reveal novel targets for treatment our study thereby works directly towards the horizon europe mission to understand treat and beat cancer
early earth mars and venus as exoplanets ease

the era of the james webb space telescope jwst has opened a new chapter in exoplanetary research we cannot understand exoplanets without looking back at the cradle of life as we know it the earth why did the earth become a habitable planet why did mars and venus evolve differently what would jwst see if it looked at the solar system planets as they were billions of years ago my team will investigate the longterm evolution of the atmospheres and spectral fingerprints of earth venus and marsi propose a unique joint evolutionary study of volcanism atmospheric escape to space and spectroscopy my team will use numerical models at the cutting edge of modern development and connect their outputs to the growing list of jwst spectra of exoplanets the team will model interior processes the evolution of lower and upper atmospheres and the evolving atmospheric spectra of earth venus and mars and their possible exoplanetary analogues our predictions of spectral features of these three planets at different evolutionary stages will be critical for the astrophysics community to identify potential habitable worlds outside the solar system and forecast their future evolution my deep expertise in stellar and planetary evolution makes me uniquely wellplaced to lead this projectthis project will not only significantly expand our current knowledge of the evolution of the earth venus and mars but will also place much better constrains on the probability for a terrestrial planet to evolve into a habitable world the team will in particular characterize possible failed analogues of earth and investigate if they could have become habitable planets under slightly different conditions by studying for the first time this unique combination of factors that are crucial for the evolution of earthlike worlds my project will break new ground in the study of exoplanetary habitability
rapidemic a lysis buffer for a novel molecular pointofcare diagnostic device for sexually transmitted infections

sexually transmitted infections sti are some of the most prevalent endemic infections in europe current diagnostic techniques for stis have important shortcomings as they rely on central diagnostic laboratories with extensive highthroughput facilities with expensive equipment and trained personnel due to this the turnover of patient samples can take up to a week in the meantime patients are experiencing shame and pain this delay in diagnosis can also have more important consequences such as continued spread of the infections of the development of pelvic inflammatory disease which can lead to infertility this is why rapidemic develops an innovative molecular pointofcare diagnostic device for fast and accurate diagnosis of chlamydia and gonorroea with this test patient samples no longer have to travel to a lab but patients can immediately get tested at a sexual health clinic this singlevisit testing provides an opportunity for immediate treatment administration and to drastically reduce the patients discomfort therby decreasing the barrier to test to detect a pathogens dna in the rapidemic test the bacteria first have to release the dna in this project rapidemic will be working on the research and development of a novel lysis buffer for gram negative bacteria suitable for integration in a molecular pointofcare diagnostic device
manybody localization in twodimensional quasiperiodic systems

systems that fail to thermalize over a long period of time are essential for both practical applications and fundamental science for the former such systems can serve as stable platforms for many future technologies that operate at the quantum level such as information storage and quantum computing devices for the latter such systems can host exotic quantum phases of matter by suppressing thermal excitations that tend to destroy the order one of the most famous classes of systems that resist thermalization is the class of manybody localized mbl systems until now it has been confirmed both experimentally and theoretically that the mbl can exist in isolated onedimensional systems either random or quasiperiodic ones in higher dimensions the fate of mbl is still unclear a famous avalanche theory predicts the instability of the mbl phase in higher dimensional random systems due to the rare regions of weak disorder however quasiperiodic systems do not contain rare regions which might stabilize the higherdimensional mbl the main objective of this proposal is to investigate mbl in twodimensional quasiperiodic systems the goal is to show whether mbl in quasiperiodic systems can survive in dimensions higher than one with a novel numerical approach which will allow me to study the dynamics of large systems 100 sites and reach long times several hundred hopping times combined with analytical calculations i plan to investigate the microscopic mechanisms behind the stabilityinstability of the mbl phase in twodimensional quasiperiodic models my research will i provide an insight into the interplay between interactions and quasiperiodicity in two dimensions ii produce a new interesting range of localization phenomena and iii present a highly tunable and experimentally accessible setting where slow dynamics and localization can be studied and possibly exploited for technological applications
viable safe and sustainable phbv value chain for food packaging applications

the european plastics policy highlights biobased plastics as a key piece to solve the negative impact of fossilbased plastics in the environment one of the most promising biodegradable biopolymers is the polyhydroxyalkanoates phas family that can replace these fossilbased plastics in many applications they are synthesised by microorganisms from renewable carbon sources and exhibit good properties and excellent biodegradabilityin this sense viss project will create a new value chain around phbv a copolymer of the phas family as a safe sustainable and costeffective alternative to conventional plastics especially for short shelflife food packaging applications due to its excellent properties including flexibility processability recyclability and biodegradability in relevant environments soil freshwater marine industrial composting and home composting viss phbv will be produced from industrial organic residues and will be formulated and compounded to be transformed and validated as highperformance food packaging being mechanically recyclable and biodegradable moreover the whole viss circular value chain will be constructed upon a collaborative approach and under safe and sustainable criteria accomplishing eu regulations and ensuring policy alignment while the project will deliver and disseminate digital tools and resources which will favour an increased social readiness and marketability of biobased plastics fostering a viss wide adoption and replicationour project gathers 15 partners from 6 european countries leaders in different fields of knowledge from bioplastic production to validation in real packaging applicationsadoption of viss value chain will produce relevant outcomes as improved functionalities and environmental performances reduction of 578 of co2 emissions compared to fossil counterparts yearly saving 117 kt of crude oil recirculating 28895 kt of biomass avoiding the use of 22 kt of hazardous substances
revolutionizing sustainable architecture with highefficiency geopolymer thermoelectric modules for energy harvesting

thermoelectric te technology which can convert thermal energy into electrical power represents a crucial clean energy innovation when integrated into the field of architecture it holds the potential to transform buildings from passive energy consumers into active energy generators furthermore it can serve as an effective strategy to mitigate the rising urban heat island effect and soaring summer temperatures which are increasingly prevalent in the european union eu in recent years te cement composites have garnered significant attention due to their robustness and costeffectiveness compared to commercial te modules however the thermoelectric performance of te cement composites typically falls significantly below the requirements for practical applications this project aims to lead the development of highefficiency geopolymer te modules for energy harvesting thereby advancing the eus progress towards achieving nearly zeroenergy buildings the proposed highefficiency geopolymer te module represents an innovative building material that can fulfill both structural mechanical and te energy harvesting roles the mechanical and thermoelectric properties of these geopolymer modules will be enhanced through the addition of various additives subsequently the project will analyze the reversibilitycyclability aging and mechanical durability of geopolymer te modules to further enhance their functionality and applicability additionally a comprehensive thermoelectrochemo numerical model will be employed and validated using data obtained from microstructural assessments of aging geopolymer te modules
towards a strategy to preserve deepsea biodiversity understanding deepsea evolution and diversification drivers of hyperdiverse marine invertebrates

for centuries biologists have been intrigued by how diverse our planet is and what processes are behind it but we are far from knowing how many species live on earth especially for deepsea invertebrates the deep ocean provides a particular scenario for diversification and remains relatively pristine however soon programmed deepsea mining activities threaten deepsea diversity even before its discovery squat lobsters are highly diverse at all levels and an ideal group to undertake a critical assessment of deepsea diversity and evolution for deepdiverse i propose to follow up a conceptual framework towards an evaluation of global species diversity of squat lobsters to assess the role of depth and deepsea habitat in the diversification dynamics supporting at the same time scientific research and conservation of deepsea diversity the action proposes 1 beyondtaxonomy a critical appraisal of squat lobster biodiversity combining extensive ecological biological morphological and genetic traits using 3d microcomputed tomography barcoding with highthroughput sequencing automatic species delimitation analyses and formal species descriptions 2 phylogenomic reconstruction using target capture sequencing uces and integrating fossil taxa to set the base to understanding the evolutionary processes behind deep sea colonisation 3 searching for diversification drivers to unveil factors shaping morphological evolution and potentially shifting diversification rates and 4 synthesis of the results towards the implementation of conservation actions comparing with other hyperdiverse taxa this includes a comprehensive spatial data integration to guide the best available management options for global seafloor biodiversity these actions will contribute to the efforts of the european union biodiversity strategy for 2030 within the european commission priority a european green deal to tackle the outstanding biodiversity crisis the world is currently facing
processing metaphors neurochronometry acquisition and decay

as the master figure of speech metaphor is a powerful communicative tool that might nevertheless come with costs for our processing system research in different fields has highlighted that a fullfledged metaphor comprehension capacity is a late achievement in development it may decay as a consequence of several pathological conditions and it evokes distinctive electrical activity in our brain compared to literal equivalents however we still miss a comprehensive framework able to account for all these empirical findings in a unitary fashion and this despite a vast number of linguistic and cognitive accounts of metaphor this project will ground on theoretical insights from the pragmatics of language to sketch a novel and comprehensive model of metaphor understanding able to account for neural developmental and clinical findings the leading hypothesis is that metaphor comprehension is an inferential process that involves first adjusting the lexical concepts and then deriving the implicated nonliteral meaning the model also takes into account the multiplicity of metaphor types which might in turn engage visual images and sensorymotor processes in line with recent multimodal accounts of lexical and semantic processing the model will be tested and refined through a series of behavioral and electrophysiological studies employing innovative experimental paradigms and involving neurotypical adults children and individuals with psychiatric and neurodegenerative diseases this multidisciplinary approach will lead to a significant breakthrough in our understanding of metaphor as the pinnacle of human verbal creativity in addition to disclosing important aspects for research on language processing development and decay