Dragon09/odtu_chatbot huggingface dataset:
regional ecosystems for multipleenergy resilient systems

the eu energy system strongly relies on centralised electricity generation and on fuel imports with 95 of its oil and 84 of its gas consumption sourced from outside the eu the repowereu plan proposes a set of actions to reduce the eus dependence on fossil fuels and diversify its energy supply well before 2030 the three pillars of the plan are to ramp up the production of green energy diversify our energy supplies and reduce our demand for fossil gas coal and oil renewable energy valleys are understood as decentralised renewable energy systems that offer a viable and efficient solution to these challenges mentioned above by implementing a high degree of renewable energy sources as well as storage technologies and intelligent management algorithms for synergetic use of a wide variety of technologies they can be 100 selfsufficient on a yearly basis for the next 5 years the reformers project aims to develop implement an exploit such an energy valley in the boekelermeer next to the city of alkmaar in the netherlands that serves as a living lab for testing and validating technologies business models stakeholder ecosystems including industrial partners dso the municipality and residents and user acceptance in reallife circumstances in a periurban and industrial environment furthermore the project aims to support the deployment of multiple selfsufficient energy valleys throughout europe beyond the flagship in the netherlands therefore it will deliver a rollout blue print and replication toolbox that encompass i energy system design ii environmental impact assessment iii stakeholder engagement and social impact assessment iv governance and policy assessment and v business modelling and allow other sites and regions to develop a pathway towards a carbon neutral and selfsufficient energy valley that can be fed into eg a sustainable energy and climate action plan
exploring the prokaryoticeukaryotic conservation of antiviral immunity from bacterial immune systems to novel antiviral drugs

bacteria have evolved multiple lines of defense against their viruses bacteriophages such weapons include restriction modification and crispr systems that have greatly impacted biomedical research studies aimed at uncovering novel defense mechanisms describe an unsuspected diversity of antiphage systems spanning thousands of protein families several of these antiphage systems such as prokaryotic viperins appear to be ancestors of major eukaryotic antiviral pathways this striking conservation between eukaryotic and prokaryotic immunity leads me to two hypotheses on which the present proposal is based first i postulate that the organisation of antiviral immunity in eukaryotes as an immune system ie an integrated network of various antiviral mechanisms might be conserved in prokaryotes this implies that each antiphage system does not act in isolation but is rather part of a whole the bacterial immune system to explore this hypothesis i will characterise the distribution of known antiphage systems encoded in prokaryotic genomes i will subsequently explore the potential synergies and coregulation existing between these systems i thereby aim to build an integrated map of bacteria antiviral immunity second i hypothesise that prokaryotes produce additional small antiphage compounds such as the viperin products with a potential activity against eukaryotic viruses to explore this idea i will study the molecular mechanisms of the viperin family i will then use genomics to predict novel chemical based antiphage systems and follow up with their experimental characterizations these projects could lead to the identification of novel antiviral molecules that could be further harnessed in the clinicoverall i expect this proposal to generate new knowledge that will have the potential to radically change our view on the immune systems of prokaryotes and provide new therapeutic leads
maintenance of platelet homeostasis by tyrosine phosphatases and vascular heparan sulfates

platelets are highly reactive fragments of megakaryocytes mks that have been implicated in all major pathophysiological processes but the molecular mechanisms controlling the number and reactivity of platelets in the circulation remain incompletely defined the prevailing thinking is that mechanical forces are the primary drivers of platelet production but the logic is flawed and the evidence contradictory what is glaringly overlooked are intrinsic inhibitory mechanisms and extrinsic cues providing a break system and directionality to mks central to this model is the concept of an mkplatelet checkpoint and gatekeeper preventing platelet production in a haphazard manner which has never been applied to this fundamental physiological process based on pioneering work from my laboratory i hypothesize that proteintyrosine phosphatase ptplinked receptors and vascular heparan sulfates hs are critical regulators of platelet production and that these receptors can be harnessed through the use of synthetic heterobifunctional molecules to regulate the threshold of mkplatelet activation and function in health and disease critical components of this mechanism include the coinhibitory receptor g6b that signals via the nontransmembrane ptps shp1 and shp2 is regulated by vascular hss and is the primary gatekeeper of the mkplatelet checkpoint and the receptortype ptp cd148 that is regulated by vascular hs proteoglycans and extracellular matrix proteins and is a master regulator of src family kinases and the threshold of mkplatelet activation findings from this proposal will revolutionize mkplatelet biology and pioneer a novel class of tools and therapeutics for investigating and treating mkplateletbased pathologies
the psychological underpinnings of nonpharmaceutical interventions

infectious diseases cripple wellbeing batter economies and kill millions annually these negative consequences can be drastically reduced via nonpharmaceutical interventions npis behaviors that reduce the spread of pathogens a wealth of recent theoretical and empirical work has illuminated how and why disgust intuitively motivates some npis such as avoiding bodily wastes and spoiled foods however disgust does little to inhibit transmission via aerosols respiratory droplets and fomites key pathways for the respiratory pathogens that circulate seasonally have caused recent pandemics and will cause the pandemics of the future hence even with advances in our understanding of disgust the psychological underpinnings of the lessintuitive npis that inhibit respiratory pathogens such as handwashing barriers to respiratory droplets and aerosols and selfisolation while infectious remain mysterious this project addresses the urgent need to better understand these npis using theory and methods that cut across social psychology evolutionary psychology health psychology and behavioral genetics first it catalogs and explains crosscultural differences and similarities in npi practices with an unprecedented survey of 50 nations and it uses a stateoftheart nuclear twin family design to assess withinpopulation genetic and cultural transmission of npis second it uses experimental methods to test the roles of folk theories of immunity moralization and conflicts between individual and collective interests on npi practices third it develops novel theorybased interventions for increasing handwashing and voluntary quarantining while sick and uses objective assessments of soap use and total daily movements to evaluate those interventions by providing groundbreaking data theory development and empiricallysupported interventions this project will arm science and society with critical new knowledge in our battle against infectious disease
establishing the investment network for startups and entrepreneurs focused on green and sustainable technologies

in4sfs project aims to increase the crossborder investment in turkish greek and romanian innovation ecosystems while improving access to capital skills of startups working on green and sustainable technologies and established in those ecosystems through the network of investors that project partners have in4sfs project will provide the crossborder investment opportunities to startups working on green and sustainable technologies and located in turkey greece and romania access to finance helps startups to use their limited financial resources on innovation at a higher level without generating a significant income especially while working on innovation activities the innovative activities lead to better results in terms of sales numbers and the overall growth rate of the startups in4sfs project will support competitiveness and global potential of green and sustainable technologyfocused startups in turkish greek and romanian innovation ecosystems through foreign investments and improve the investment readiness of startups to assist foreign investors located in the netherlands france and denmark to access local deal flows in4sfs project will use the local project partners and establish information centers in turkey greece and romania through the knowledge of partners in local ecosystems these information centers will help foreign investors to access local deal flows in terms of informing foreign investors from the netherlands france and denmark on local regulatory frameworks and supporting them to establish joint crossborder ventures in turkey greece and romania four brokerage events will be organized these events will be focused on investors and a joint crossborder venture opportunity will be looked for
digitalisation for biocultural diversity and environmental justice

does the digital divide deprive movements for environmental justice ej and in defence of biocultural diversity from the benefits of digitalisation diverses hypotheses resist the idea from drone monitoring of forests to indigenous digital media and online mapping to vindicate stories of resistance and transformation a digital transformation from the ground up may not only be paving the way for just and diverse futures but also for an alternative understanding of digitalisation yet no largescale scientific study has examined the occurrence of digitalisation in grassroots transformative initiatives gti nor theorised its effects while eliteand growthdriven digital innovations are redefining lifestyles and overall imaginaries of the future a strong debate in the fields of political ecology and ej involves two confronted views celebratory vs technophobic on the likelihood of enfranchising technologies diverses overarching goal is to theorise an alternative model of digital transformation rooted in relationality care community personal connection that emerges from gti in their pursuit of diverse worlds and ej the groundbreaking approach combines qualitative data from expert interviews and databases compilation worldwide to casestudies and biographical interviews across continents with quantitative methods and models to analyse these data eg two newly created indices transformative effectiveness and gti digitalisation and a first global compilation of digital practices in gti offering both an understanding of causal chains and a basis for generalisation diverse proposes the new concepts of lifecentred digitalisation including both livelihoods and ecology and situated digital leadership disclosing the specific links of digitalisation with changes in material experiences situated knowledge and placebased digital ecologies my ultimate goal in terms of theory is to lay out the foundations of a political ecology of digitalisation
dissection of the hostmicrobe crosstalk that controls metabolism and physiology in intestinal symbiosis

intestinal bacteria have been associated with the most diverse aspects of our physiology and large efforts are being undertaken to determine how the metabolic repertoire of the microbiome impacts host nutrition and health these efforts however face major obstacles first we have a very poor understanding of how bacterial metabolism is regulated in the different sections of the gastrointestinal tract it is also becoming increasingly clear that symbionts support their hosts by means that extend beyond the provision of nutrients and these effects can hardly be predicted from metagenomic analyses we will use ambitious approaches borrowed from several fields including microbiology genetics and cell biology to dissect how the crosstalk between hosts and their symbionts shapes metabolism and physiology at the scale of the holobiont we will leverage the relevant drosophila gastrointestinal tract and use multiomics approaches to dissect in mechanistic depth how the metabolism of a model enteric bacterium is regulated in the different sections of the digestive tract aim 1 the microbe in parallel our work suggests that symbionts exert a broad control over intestinal digestive and metabolic activities and act potentially through host bacterial sensing and epigenetic mechanisms to play these roles we will dissect these regulatory links in drosophila and investigate their conservation in mammals aim 2 the host finally we have evidence that hosts cooperate with their symbionts to regulate gastrointestinal transit a vital but underappreciated factor that shapes nutrition in both partners we will use twosided genetic screens to uncover the bacterial metabolites and the host factors that regulate transit and determine if this regulation involves the gutbrain axis aim 3 the holobiont together these studies will bring major advances in our understanding of the nutritional and metabolic interactions between hosts and their symbionts
bottomup chemical construction of photosynthetic cyanobacteria mimics and their controlled assembly into autonomous and selfregulating biofilmlike materials for hydrogen production

broad interest is devoted nowadays to filling the breach between biology and chemistry in order to comprehend the frontier between living and nonliving systems in this context protocells are autonomous and selfsustained entities fabricated from scratch which may exhibit one or more characteristics of actual cells this project aims at synthesizing cyanobacteria mimics capable of producing h2 and formaldehyde from visible light water and methanol the active material for photosynthesis shall be a semiconducting heterojunction based on bivo4 and rhdoped srtio3pt for zscheme photocatalysis the photocatalyst shall be contained within functional proteinpolymer protocell membranes referred to as proteinosomes these photosynthetic protocells will then be chemically programmed to selfassemble into the first autonomous and photosynthetic biofilmlike material bfm the careful threedimensional design of the bfm consisting in a combination of mechanopassive mechanoactive and photocatalytic layers of specialized proteinosomes will allow an emergent and unprecedented photomechanochemical transduction therefore the bfm will be able of an autonomous and selfregulating behavior out of equilibrium this proposal pushes forward the borders of bottomup synthetic biology via a nice interdisciplinary interaction with semiconductor photochemistry furthermore an alternative and sustainable route to the production of green fuels is provided which brings an original solution to the current planetary energetic crisis
theoretical foundations of advanced synthesis

the rapid development of complex and safetycritical systems requires reliable verification methods in automated synthesis we transform a specification into a correctbyconstruction system in recent years there have been significant advances in the algorithmic front of synthesis still the integration of synthesis in industry has been slow this project addresses two critical reasons why synthesis has been hindered first while verification offers designers a tool to check their designs synthesis aims to replace manual design designers will give up manual design only after being convinced that the automatic process replacing it indeed generates systems of comparable quality which current definitions of synthesis ignores second designers can cope manually with simple settings thus automated synthesis is needed in complex settings which are not covered by current definitions of the problemmy overarching objective is to develop the theoretical foundations of advanced synthesis namely the next generation of synthesis concepts and algorithms taking into account the complex settings in which synthesis is needed and the many considerations that are abstracted in current definitions of the problem i will formalize and study the following three aspects of advanced synthesis 1 quality and complexity measures behavioral quality as well as complexity measures that refer to resources needed by the synthesized system 2 gametheoretic considerations settings with components that may or may not collaborate in order to cooperatively or selfishly achieve individual and common objectives 3 evolving and unpredictable environments behavioral structural and conceptual assumptions on the environment the research will be based on clean mathematical foundations and will combine the above methodological contributions with advances in the theory and applications of automata on infinite objects
translational research network in motor disorder rehabilitation advancing understanding of variability in motor control and learning to enhance clinical practice

the theoretical understanding of human motor control and learning has a strong impact on the diagnosis and treatment of motor disorders and vice versa recent progress has been made in the understanding of motor control and learning particularly with respect to understanding the functional role of neurobehavioural variability that is inherent to sensorimotor control however this progress has not yet been transferred appropriately into clinical therapy approaches the goal of trend is thus to create a translational research network in motor disorder rehabilitation the network will be highly interdisciplinary with doctoral and senior researchers from fundamental research areas movement science neuroscience computer science clinical practitioners physical and occupational therapy rehabilitation science etc and partners from related industries the overall aim is to systematically translate recent theoretical and methodological advances in motor control and learning research into clinical practice to enhance clinical diagnosis and motor rehabilitation more specific we will investigate the functional role of variability in the sensorimotor coordination dynamics on behavioural and neurophysiological level in motor and mental disorders such as stroke parkinsons or alzheimers disease this will be addressed in three research objectives 1 to investigate how different disorders affect the sensorimotor systems capability to exploit functional variability for stable and adaptive motor control 2 to investigate how novel therapy concepts can enhance the capacity to exploit functional variability and treat motor disorders across different patient populations and 3 to develop novel approaches to translate the knowledge gain from our fundamental research into clinical practice
efficient exploration of climate data locally

despite the wealth of climate data and services currently available access is often limited to scientists and modeling experts focal will develop a platform focal platform that combines intelligent workflow management with highperformance computing hpc infrastructures featuring data and metadata management linked to artificial intelligence ai development routines this environment will enable the fast and efficient training and validation of innovative ai and statistical methods enhancing the understanding of climate change impacts at a local scale the project focuses on two pilots urban planning and forestry intending to develop a platform that enables efficient climate impact assessments on the local level while leveraging ai and hpc for analysing earth observation eo and earth system modelling data furthermore focal will generate new insights into key processes of the earth system by integrating advanced eo data with existing and new data assimilation or modelling approaches by harnessing a diverse range of eo datasets focal will improve climate predictions and provide a more comprehensive understanding of the interactions within the earth system this integration will allow for the identification of previously unrecognized patterns and feedback mechanisms ultimately refining local climate models and enhancing their predictive capabilitiesthe platform will also facilitate webcloud app development through a codesign process with urban planners and foresters ensuring the resulting applications address their specific impact assessment challenges additionally the focal ecosystem will support developers particularly small and medium size enterprises smes by providing services modules tools and workflows that can be integrated into their own solutions the project promotes a highly interdisciplinary approach with a defined clustering and dissemination strategy to effectively apply its innovations across various fields an open geospatial consortium domain working group ogcdwg will be established to manage and maintain these clustering efforts ultimately focal aspires to enhance climate science and policy improve societal resilience to climate change and promote sustainable practices all while ensuring transparency and openness in data management and model development
unraveling how evidence accumulation determines conscious experience using voltammetry

consciousness entails the phenomenal experience we have of the world and ourselves although it is at the heart of major philosophical scientific and ethical issues our understanding of the neural mechanisms of consciousness remains limited the study of consciousness is compartmentalised with researchers focusing on isolated subaspects of the problem via restrictive paradigms that ignore the temporal dynamics of conscious experience its metacognitive component or its dependence on levels of consciousness moreover we know virtually nothing about the singleneuron and neurochemical basis for consciousness in humansvolta will advance beyond these empirical and theoretical limitations by conducting a multidimensional and multiscale study of consciousness the project builds on a computational framework i recently developed linking consciousness to evidence accumulation it will utilise the clinical context of pharmacoresistant epilepsy to collect unprecedented behavioural and neural data individuals with epilepsy will participate in novel behavioural paradigms quantifying multiple dimensions of conscious experience including its temporal dynamics metacognitive components and existence under sleep and anaesthesia these experiments will be combined with triple neural recordings that simultaneously characterise 1 the global activity of neural populations 2 spiking activity of individual neurons and 3 electrochemical activity by measuring neuromodulator release with voltammetry these unprecedented recordings will provide a multiscale map of the neurobiological basis of consciousness my team and i assisted by international experts will interpret this rich dataset in light of seven preregistered hypotheses derived from my computational framework in summary volta will carry out a firstofakind withinsubject study to reveal the electrophysiological and electrochemical mechanisms of the multiple dimensions of consciousness