Dragon09/odtu_chatbot huggingface dataset:
investigating orthopara conversion of trihydrogen cation in space

the simplest polyatomic molecule trihydrogen cation serves as a useful benchmark for fundamental quantum chemistry and has profoundly impacted astronomy it was first detected in the interstellar medium in 1996 and has been recognized for its pivotal role as a universal proton donor and an initiator of ionmolecule chemistry producing many of the molecules detected in spaceinterstellar chemistry is an exciting chemical playground of thermodynamics and kinetics as the molecules can require up to days or even weeks to reach thermal equilibrium in the lowdensity cold environments a longstanding astrochemical conundrum has been the population distribution between the two nuclear spin modifications of trihydrogen cation ortho and para as it has important implications for its use as a cosmic ray ionization probe in reactions involving identical particlesfermions like trihydrogen cation restrictions are introduced due to the pauli principle which can significantly increase the time required to reach a thermal equilibrium this makes the chemistry especially the kinetics of the ubiquitous trihydrogen cation in these regions both exciting and challenging to understand in our terrestrial laboratories here i propose to use a cryogenic ion trap to isolate the nuclear spin states of trihydrogen cation which is the first of its kind for a polyatomic molecule recently developed in the hosts group beyond the intriguing fundamental chemical physics of this system isolation of the nuclear spin states will be exploited to study the quantum statespecific kinetics down to 10 k for the reaction between molecular hydrogen and trihydrogen cation which is one of the most common bimolecular reactions in the universe performing these challenging measurements with a critical impact on our understanding of astrophysical processes will not only increase my skill set but also contribute towards my position as an emerging leader in astrochemistry
learningdriven and evolved radio for 6g communication systems

6gleader aims at evolving the phy and ran aspects of 6g communication networks by relying on the following pillars 1 mlempowered phy algorithms with predictive capabilities towards fully autonomous operation 2 fullduplex transceivers employing novel sparse antenna arrays and advanced digital selfinterference cancellation 3 nonorthogonal and random multiple access schemes to accommodate mass connectivity demands of users and machines 4 goaloriented semantic communications and 5 an open and disaggregated ran implementation with xapps integrating the advancements achieved during the projects lifetime
collective responsibility towards nature and future generations

this research proposal aims at rethinking a collective and proactive concept of responsibility towards nature and future generations on the basis of the understanding of nature developed by german idealism in the early 19th century and the theory of responsibility first advanced by hans jonas in the 20th century i will articulate my research into two steps which aim at two objectives 1 i will first work on the rational foundation of collective proactive responsibility towards the world in which we live that is the duty to take care of it this is the objective side of my research in the sense that it grounds on a consideration of human beings as rational and responsible agents in themselves in a kantian sense to reach this first objective which is the most challenging one a further step is needed the elaboration of a concept of nature and its relation to human being able to take into account 11 the ontological continuity between nature and human being and with this the value of nature and life in themselves 12 the primary responsibility of humans all this will be possible analyzing and revitalizing the concept of nature in german idealism and studying its ethical implications 2 second i will investigate the role of human motivation the context and the consequences of human action as essential part of any theory of responsibility this is the subjective side of my research that aims at providing the bridge between the formal foundation of the concept of collective responsibility and its application in this part my research will deal with the key concepts of respect care towards vulnerable nature and future human beings and fear of a collapse of nature and our future lives the concept of collective responsibility generated by this project might show its fertility also with reference to contemporary debates like those related to environmental issues
proteomic optimization of methods for ancient skeletal elements

palaeoproteomics has the potential to resolve some of the big questions in palaeoanthropology and human evolution as proteins have been found to preserve over long time periods in the archaeological record and contain phylogenetically relevant information however as this is a relatively new field of research method optimization and gaining further understanding of ancient proteomes is necessary to gain robust and reliable results with minimal destruction to rare ancient fossils to this end promise proteomic optimization of methods for ancient skeletal elements aims to improve palaeoproteomic analyses by developing and thoroughly assessing methods for removing modern contamination from ancient specimens releasing proteins from the mineral matrix of bones and teeth and understanding the effect that postmortem microbial bioerosion has on ancient skeletal proteomes finally these optimised methods will be applied to study middle and late pleistocene levantine hominins the levant is essential for understanding human migration out of africa as well as interactions between different contemporaneous hominin populations but is a challenging area of study for ancient dna warranting further palaeoproteomic method development promise will advance methods for the entire field of palaeoproteomics as well as the study of human evolution promise will be conducted in a dynamic international research environment providing the fellow with essential skills setting them up for a successful future career as a researcher in archaeological science
a completely biological and human tissueengineered mesh produced from cellassembled extracellular matrix cam in vitro for the treatment of pelvic organ prolapse pop

pelvic organ prolapse pop is a major medical issue for women it is estimated that 1 in 10 women will undergo a surgery to treat pop during her lifetime to provide mechanical support to the slipping organ strong and stiff synthetic meshes have been used transvaginal meshes are now withdrawn from the market in many countries due to high complication rates hence there is a strong medical and societal need for breakthrough innovationswe propose a new paradigm targeting the fundamental problem of synthetic meshes ie the foreign body reaction by providing a completely biological tissueengineered mesh to treat pop our strategy is based on a unique biological material the cellassembled extracellular matrix cam produced by cells in vitro robust cam sheets are cut to produce yarn subsequently knitted into a meshin 12 months this proof of concept poc aims to deliver unambiguous experimental evidence that a cambased tissueengineered mesh has the potential to become a relevant alternative surgical solution to treat pop this project is divided in 2 main tasks1 production and mechanical characterization of a human cam mesh and of an equivalent ovine mesh with properties justifying a preclinical test2 in vivo validation of an allogenic cam mesh in a female sheep model at 2 and 6 monththis poc will provide1 proof that a human cambased knitted mesh can have clinically relevant mechanical properties2 demonstration that an ovine cam mesh can be successfully implanted to treat pop in a clinically relevant allogeneic large animal model3 direct comparison between the biointegration of an ovine cam mesh setting and the inflammatory response to a synthetic meshoverall this poc will increase the technology readiness level of our product from 12 to 34 by validating the functionality and safety of cam meshes in a relevant in vivo environment these outcomes will lead us closer to clinical trials and support a commercial endeavor
novel optical nanocomposite sensors for analysis of micro and macro elements in corn plants

sens4corn is targeted to strengthen intersectoral and interdisciplinary collaboration in optical composite nanomaterials for optical chemical sensors the main project goal is development of novel optical nanocomposite sensors for analysis of micro and macro elements in corn plants we will investigate schiff bases sb and metal organic frameworks mof optical composites znosb and znomof with advances optical and their sensitive properties towards anions and cations present in corn micro and macro elements the sensitive composites will be integrated into microfluidic system combined with fiber optic detection system the system will be used to validation of real corn samples the sensing system will reduce time and cost of the measurements by standard chromatography methods the sensing system has good potential of commercialization in agriculture sector as a new rapid service for corn growth analysis for small and medium farm companies the project is interdisciplinary and it involves material science chemistry surface science optical analytical chemistry nanotechnology and agriculture the project will create new service for improvement of agriculture production thus improving industrial and health potential of eu citizens during the project research and management training will be provided to technicians experienced and early stage researchers to strengthen their personal skills improve their track record and expertise via new scientific papers and conference presentations and strengthen a development of eu research human resources long lasting collaboration between partners based on cosupervising students and preparation of novel collaborative project proposals is foreseen dissemination of project results will make an impact on agriculture sector and eu research potential in the fields of material science nanotechnology and optical sensors
monsoon asia as the nexus for the transfer of tantra along the maritime routes

tantra dominated the hindu and buddhist socioreligious landscape across much of southeastern asia from ca the 7th to the 13th century once perceived ambivalently by scholars and often still misrepresented in global pop culture as a form of sexual practice the study of tantra has now become a burgeoning academic subfield however the impact of tantra on the religiocultural history of asia is still underappreciated and disciplinary limitations as well as the area studies paradigm fragmenting asia into discrete areas hamper our global understanding of this translocal phenomenon transcending these boundaries the project will study tantra from the perspective of cultural contact between different communities across the geoenvironmental region referred to as monsoon asia approaching the phenomenon in a global manner and in terms of connected histories rather than in isolation according to distinct regional contexts taking the medieval as its chronological framework it will investigate textual corpora in sanskrit vernacular and nonindoaryan languages that have seldom been studied in a comparative manner and complement the textual data with art historical evidence in so doing it will frame the emergence transfer and transformation of tantra as a mobile and multicentric network of people languages and objects that circulated across a vast interconnected region sharing common geoenvironmental factors eg the periodical monsoon winds besides uncovering the interactions between elite and nonelite sociocultural milieus in the constitution of tantric traditions it will also transcend the asymmetrical framing of premodern cultural relations between south asia and the remainder of the wider indic world and highlight the shared religious heritage in a vast region that hosted the majority of the world population both historically and in the present which has been artificially fragmented by national and global geopolitical configurations
building a sustainable european innovation platform to enhance the repurposing of medicines for all

remedi4all aims to establish europes leadership globally in the repurposing of medicines by creating a vibrant community of practice covering all relevant sectors and disciplines remedi4all will establish and operate a permanent european research and innovation platform comprising the complete value chain for cutting edge patientfocused repurposing collaborating with users to execute high potential projects at any phase of development upskilling all stakeholder groups through a comprehensive education and training portfolio and advancing crosssectoral policy dialogue with all relevant stakeholders and thought leaders the tools and processes developed assembled in remedi4all will be validated in a portfolio of 4 ambitious preclinical and clinical phase demonstrators representing high patient need in a variety of disease areas including oncology rare and infectious diseasesthe remedi4all platform will operate a complete harmonised and accessible value chain integrating the scientific methodological financial legal regulatory and intellectual property aspects of the repurposing approach in a goaloriented and patientcentric approach working closely together with research funders and the patient community remedi4all will engage and support a substantial user base and concomitant investments through a permanently sustainable entity working closely with the permanent european infrastructures and partners the community of practice comprises leading academic and clinical facilities and infrastructures medicines regulators health technology assessors public agencies and funders small and large industry stateoftheart artificial intelligence and in silico tools and a global network of collaborators for optimal knowledge exchange remedi4all will substantially increase europes capacity to develop high quality repurposed medicines and implement them into market through its complete value chain and consensusbased policy development mission
the nutricheck network to maximise sitespecific precision in managing the nutrition of european arable crops

europe faces huge and urgent challenges of increasing crop productivity whilst reducing use of synthetic fertilisers and nutrient losses this proposal is to establish a selfsustaining multiactor thematic network called nutricheck net that builds farmlevel adoption of best fieldspecific nutrient management practices across europe in nine countries farmers crop nutrition clubs cnc will identify and share the nature of their uncertainties about crop nutrition their challenges and barriers to change decisionsystems and nutrition tools including commercial products services and recent research outputs will be assembled by national experts from across europe including leading farmers into a common online nutricheck net platform cncs will then evaluate effectiveness of new protocols and tools selected from the a toolbox to meet their main challenges thence they will cocreate and adopt farm and fieldspecific measuretomanage approaches that address their crop nutrition challenges evaluations of protocols and tools by farmers and experts will address their ease of use trustworthiness costs and benefits initial and final evaluations will be shared across the network to define best practices which will be demonstrated and disseminated widely including through liaison with other relevant thematic networks and eipagri the toolbox and best practices will be held accessible and improvable in perpetua on eu farmbook widespread adoption of measuretomanage or checktochange approaches to crop nutrition will enhance nutrient recycling and crop productivity whilst reducing synthetic fertiliser use and nutrient losses across europe
a quantum approach to symbolic dynamics

this project in pure mathematics aims to solve problems in symbolic dynamics a mature branch of dynamics with important connections to coding theory information theory and operator algebras using tools from the modern theories of quantum information and quantum groups the central challenge dating back to at least the 1970s is to classify symbolic dynamical systems my proposal pioneers a highly interdisciplinary and novel approach using the uniquely quantum phenomena of entanglement and noncommutativity as they appear in quantum informationquantum groups the main objective is therefore to establish a fruitful connection between symbolic dynamics quantum information theory and quantum groups to the benefit of all three communitiesthe proposal is based around two central open problems how do we classify symbolic systems and what are the symmetries of symbolic systems a novel approach to these problems builds on the recent advances made in part by the supervisor that connect graph theory with quantum informationquantum groups i introduce a new nonlocal game the conjugacy game that will define quantum conjugacies and a notion of quantum automorphism that will define quantum symmetries of symbolic systems this marks the first interaction between quantum informationquantum groups and symbolic dynamics the ideas are therefore very timely will have high impact and set a precedent for future uses of quantum mathematics in other domains and specifically other classes of dynamics eg multidimensional subshifts and algebraic actionsthe fellowship will strengthen my academic career via the opportunity to learn new tools in quantum mathematics and apply them to solve important problems in dynamics it will also allow me to establish new collaborations with leading experts in dynamics and quantum informationquantum groups that will play a key role in my goal of obtaining a permanent academic job and an investigator grant to build a research g
delegating decisions an overlooked way of pursuing immoral goals

modern societies are tormented by warfare crime corruption and environmental exploitation if many people have prosocial goals and desire to see themselves and to be seen by others as moral how do immoral acts like these continue to happen economic research suggests a critical role of delegation decisionmakers can delegate unethical yet profitable decisions to delegates which increases resource inequality and at the same time averts punishment of delegators yet such indirect immorality as an inherently elusive inconspicuous phenomenon is not only overlooked by observers but also by psychological research who delegates immoral behaviors when and why what determines observers reactions to delegators i propose the new 3r framework of delegation and test it in three empirical work packages spanning diverse methodology from social moral and cognitive psychology and behavioral economics people employ delegation strategically to reap the benefits of immoral acts while effectively avoiding responsibility and protecting their moral reputation in the eyes of others basic socialcognitive mechanisms explain these intra and interpersonal benefits of delegation whereas previous work often focused on the few callous individuals who do not care about moral norms the 3r framework assumes that precisely those who are morally motivated delegate immoral decisions to minimize their guilt and escape social blame moreover i predict and test an important asymmetry in how observers assign blame and praise for delegated immoral versus moral behaviors given the fundamental psychological nature of immoral delegation it should be frequent in peoples everyday lives and should already be observable in children taken together the project aims to comprehensively study delegation under a unifying framework it will contribute a groundbreaking new perspective to the study of immoral behavior and thereby illuminate the complex social nature of human morality
phylogenomicdriven drug discovery from rhodococcus and saccharomonospora using 2d and 3d cell cultures

the project titled phylogenomicdriven drug discovery from rhodococcus and saccharomonospora using 2d and 3d cell cultures aims to explore the microbial diversity and genomic landscape of two important yet somewhat neglected natural product producing actinobacterial genera rhodococcus and saccharomonospora symbiotic systems and unique habitats will serve as isolation sources of novel species and i will employ stateoftheart sequencing techniques to perform a comprehensive in depth phylogenomic analysis to fully depict their biocatalytic repertoire and by doing so unravel their unique natural product potential i will spearhead the establishment of novel 2d and 3d cultivation techniques with ecomimetic properties to mimic natural scenarios and thereby trigger the production of cryptic metabolites i will employ sophisticated dereplication and chemical analytical strategies to characterize and structurally elucidate novel chemical entities with druglike scaffolds based on these results i will be able to test all of the identified natural products for their pharmacological properties within the framework of the helmholtz drug discovery pipeline and collaboration partners my targeted and interdisciplinary research approach will allow me to gain valuable genomic and evolutionary insights and streamline the discovery of pharmaceutically valuable natural product scaffolds
development of superabsorbent biomaterials based on oat protein through electrospinning and 3d printing

superabsorbent materials sams can absorb and retain large amounts of water 10 times their weight hence they have many applications such as soil conditioners diapers menstrual pads and wound dressings thus in 2021 sams global market was valued at 86 billion however one of the main concerns about their use is that they are often based on acrylic acid and polyacrylamide which are petroleumderived difficult to degrade and their degradation products could be toxic the superbiomat project will take this challenge by developing sams based on oat protein op the specific objectives are to increase water binding capacity of op through chemical functionalisation to process op through electrospinning and 3d printing and to evaluate the potential of superbiomat in different applications op is an underexploited byproduct after glucan extraction however its high lysine content makes it a good target for functionalisation by acylation to enhance its water binding capacity electrospinning and 3dprinting could be particularly interesting for developing sams yet not fully explored for protein matrices the superbiomat project will revalorise op and open a portfolio of new biobased sams a commercial interest in the results of this project is expected and protection of ipr will be prioritised amongst general public and targeted audiences the project will raise awareness of the pollution created by petroleumderived sams and their potential toxicity this project is in line with a more sustainable production system and the 17 sustainable development goals un agenda 2030 superbiomat will be carried out by dr barbara tomadoni with the supervision of prof antonio guerrero at university of seville spain the researcher will gain maturity and independence through the realisation of this project following her training and career development plan thanks to the supervisors experience and the host institutions education and training programmes