Dragon09/odtu_chatbot huggingface dataset:
holistic capability and technology evaluation and cocreation framework for upskilled first responders and enhanced cbrne response

countries worldwide amid threats and incidents targeting civilians invest in reinforcing their cbrne related capabilities in europe and in most cases the teams responding first are not trained specifically nor equipped sufficiently to face the kind of hazards to provide the assistance to victims and to follow the decontamination processes that a cbrne incident implies at the same time resources are limited exercises and trainings are siloed per organization lacking of proven procedures and digital tools teamup addresses these challenges establishing a unified framework of evaluating capabilities procedures and codeveloped solutions to be used in cbrne preparedness and response the process results to an innovative toolkit for detectionidentificationmonitoring coordinated operations and efficient and safe sar supported by ar digitally upgraded triage and breath analysis fastly deployable mass decontamination system and monitored people and infrastructure decontamination also it offers incident management and digital training tool for frs and citizens enhancing preparedness and response teamup brings several actors together training centers frs experts and nonexperts identifying their specific needs enforcing in parallel crosssectoral crossborder collaboration and facilitating knowledge sharing through a continues evaluation approach in a rich programme of tabletop smallscale exercises as well as small scale and fullscale trials proving new knowledge on capabilities technology performance and operating procedures the solution will be finally validated in france and in greece through the extensive participation of 8 end userorganizations and a very competitive technical team experienced in eu impactful funded projects aspiring to create a ready to market solution teamup will also contribute by initiating an euwide process on standardizing quantitative and qualitative metrics and procedures for decontamination validation
boronic acids as a new strategy to boost betalactam antibiotics for the treatment of tubercolosis

tuberculosis tb is a highly infectious disease caused by mycobacterium tuberculosis mtb one of the most dangerous aerobic bacteria the need for longterm treatments and the increase in drug resistance mechanisms make it necessary to urgently develop new strategies to combat this potentially lethal pathogen betalactam antibiotics bla are the most widely used and safest antibiotics in the clinic and include several classes such as penicillins cephalosporins and carbapenems however historically these agents have not been used to treat tb there are two mechanisms of resistance to bla in mtb the cell envelope rich in lipoglycans which acts as a barrier for the penetration of many drugs including bla and the expression of blac a specific betalactamase enzyme capable of hydrolyze and inactivate the bla recent studies have shown that the combination of meropenem a betalactam carbapenem amoxicillin a betalactam penicillin and clavulanate a betalactamase inhibitor markedly reduced the mtb load in the patients sputum after two weeks therefore giving new hope to the use of bla to tackle the tuberculosis epidemic this proposal aims to develop new compounds that behave as bla adjuvant for antimtb treatment with a dual mechanism of action we will design and synthesize novel boronic acid transition state inhibitors batsis as inhibitors of blac the betalactamase expressed in mtb and investigate whether they can be derivatized to become disrupting agents of mtbs unique outer capsule made of lipoglycans to promote better penetration of drugs into the cell this project will also investigate the possibility of improving the penetration of molecules into the necrotic granuloma formed in vivo as part of the disease process by developing a lipidbased prodrug strategy to achieve these specific objectives the project will be divided into three main work packages involving a combination of biological chemical and analytical expertise
response of the earth system to overshoot climate neutrality and negative emissions

the rescue project will improve knowledge and understanding in area c of this call climate and earth system responses to climate neutrality and net negative emissions by pursuing two overall objectives 1 quantify the climate and earth system responses to pathways achieving climate neutrality by carbon dioxide removal cdr deployment with and without temperature overshoot and 2 assess the potential role of cdr in reducing net ghg emissions as well as its potential environmental risks and cobenefitsrescue will expand existing knowledge on cdr methods to design a suite of new global temperature stabilization scenarios at several target values to achieve the first objective new model developments will deliver improved climate projections with explicit representation of cdr portfolios for these scenarios the analyses will be devoted to finding suitable pathways to climate neutrality considering multiple aspects of the earth system response mean climate and extremes sealevel rise global carbon cycling biodiversity and ecosystem services particular attention will be paid to the reversibility of induced changes by comparing scenarios with and without temperature overshoot the second objective will be achieved by analyses assessing various factors determining overall effectiveness impacts and cobenefits of cdr portfolios these factors include cdrspecific co2 uptake cdrinduced biogeophysical climate feedbacks cdrderived nonco2 radiative forcers and the interaction between socioeconomic and environmental impacts eg biodiversity moreover a dedicated analysis will provide key criteria for developing a monitoring system for the effectiveness of cdr portfolio deployments and their potential side effects stakeholders will be closely engaged throughout the project to ensure policy relevance and final update of the results which will be made freely available via existing climate services
economic legal and ip feasibility studies of exheus vital test

exheus vital is a unique evidencebased innovative solution that supports hcps in providing personalized treatment plans and recommendations to people suffering from obesity to effectively achieve weight management goals the proprietary technology is based on individuals gene activation analysis that is converted into insightful health intelligence reports which provide information on the health status of the individual allow monitoring of patients overtime and a prognosis of possible pathologies exheus leads to unparalleled health outcomes benefiting the individual and the society by driving costeffectiveness of therapy exheus vital offers advantages such as1the information provided together by the rna sequencing and by the exheus ai technology allows to obtain precise information of the abnormalities in gene expression for each patient this allow a high level of personalization that cant be achieved with other methods to provide the best treatment for a given patient2it allows to increase the adherence to the weight loss treatment increasing the effectiveness of the recommendations3it helps hcps motivate the patient and improve willingness to follow the health recommendations therefore promoting a change in lifestyle habits sustainable over the time4hcps ie endocrinologist primary care physicians can now treat obesity through a clinically validated personalized medicine tool to guide and accompany the patient during its healthy weight loss process5monitoring the evolution of activated genes over time can be done through repeated tests to determine changes in these parametersexheus vital is a fast effective and attractive tool that helps health care professionals hcps to efficiently support patients with obesity in their weight loss goals it has been demonstrated that the delivery of the scientifically proven insights expression levels and changes and recommendations using a digital method will be effective
mooring lineseabed interaction considering trench development and its application in integrated analysis of floating wind turbines

offshore floating wind turbine fwt provides an efficient solution to address climate challenge integrated analysis of fwt is vital to reduce the uncertainties in design and save costs in the field seabed trenches dramatically increase the failure risks of mooring system and raise operation and maintenance costs however the mooring lineseabed interaction related to soil erosion and trench development is not considered in design code dnvglst0119 2018 thus two objectives of this project are 1 reveal the trigger factor for seabed trenching due to the mooring linesoil interaction simulate the trench development with time 2 establish the macro element model considering seabed trenching process integrate the model into the integrated analysis tool of fwts eg sesam a total of 3 packages are designed comprehensively in the seabed trenching package conduct 1g erosion test to reveal the trigger factor for seabed trenching wp11 then propose the soil erosion model based on analytical analysis based on 1g erosion test wp12 finally the trench development will be simulated by the trench profile model wp13 in the mooring lineseabed package get the chain resistance by 1g result wp21 establish the macro element model wp22 considering seabed trenching process which can consider the soil degradation erosion removal wp23 in integrated analysis package integrate the model into the integrated analysis tool of fwts eg sesam wp3 the new development of the soil erosion model seabed trench model and macro element of mooring line soil interaction are the new computation tool for scientific analysis integrated analysis tool for fwt will be an important and powerful tool for fwt analysis considering mooring linesoil interaction which will contribute to standards setting this will be a groundbreaking progress and will fill the gaps in the norms and standards dnvglst0119
stabilising autopolyploid meiosis for enhanced yield

hybrid breeding has been one of the biggest contributors to yield increase of the last century hybrids are individuals which have genetically different parents which results in a hybrid vigour effect this hybrid vigour effect can confer advantages over inbred parent lines in growth yield and resilience and tolerance to different types of environmental stresses important for securing agricultural production in a changing climate an even greater hybrid vigour effect is possible in autopolyploids which can have up to four different copies of each chromosome than in diploids which have can only have up to two different copies of each chromosome in effect double hybrids can be made in autopolyploids with up to four different parents contributing to hybrid vigour in a single individual however to date the double hybrid effect has almost never been used for breeding most of our crops are not autopolyploids we can induce autopolyploidy through chromosome doubling but this causes meiotic instability where multiple crossovers occur between the four chromosome copies during meiosis this pairing disruption leads to potential loss of chromosomes and chromosome fragments essential for seed fertility and viability although induced autopolyploids are meiotically unstable this is not the case for established autopolyploids in the majority of established autopolyploids a maximum of one crossover per two homologous chromosomes during meiosis is strictly enforced thus achieving 100 pairing and correct segregation of chromosomes into daughter cells i propose to stabilise meiosis in induced autopolyploid brassica rapa turnip chinese cabbage by knockout of crossover promoting genes overexpression of crossover suppressing genes and selection of natural genetic variants stable autopolyploids will be used to produce doublehybrid lines which will be evaluated for hybrid vigour for yieldrelated traits
adaptive laser beam for additive manufacturing

the alabama project aims to develop and mature adaptive laser technologies for am the objective is to lower decrease the porosity and to tailor the microstructure of the deposited material by shaping the laser beam both temporally and spatially during the am process the key innovations in the project are to develop multiscale physicsbased models to enable optimization of the am process these process parameters will be tested and matured for multibeam control laser beam shaping optics and highspeed scanning to ensure the quality of the process advanced online process monitoring and closed loop control will be performed using multi spectral imaging and thermography to control the melt pool behavior coupled with wirecurrent and highspeed imaging to control the process to verify that the built material fulfills the requirements advanced characterization will be conducted on coupons and on usecases the matured technology will be tested on three usecases aviation maritime and automotive these three industrial sectors span a broad part of the manufacturing volumes from low numbers with high added value to high numbers with relatively low cost however all these sectors struggle with distortions stresses and material quality the alabama usecase demonstrators will improve the compensation for distortions during the am process reduce the build failures due to residual stresses reduce porosity and improve tailoring of the microstructure overall this will contribute to up to 100 increase in process productivity 50 less defects 33 cost reduction due to increased productivity and energy savings a reduction of 15 in greenhouse gases and enable first timeright manufacturing thanks to simulation process monitoring and adaptive control the end users will insert the technologies while the subtechnologies developed in the work packages will be commercialized this will increase the autonomy for a resilient european industry
microbial biopesticides to control disease vectors and agricultural pests

the proposed era chair prof george dimopoulos completed his phd at imbbforth in 1996 and has through a remarkable career path harvard embl imperial college johns hopkins become a worldleader in the field of vector biologymicrobial biopesticides he will establish the microbiopest research team at imbb aiming to develop environmentally safe microbial biopesticides for tackling vectors of human diseases and agricultural pests the research plan includes innovative components and state of the art methodologies for the identification of insecticidal microorganisms elucidation of the nature and mode of action of microbial biopesticide and prototype product development this project and research line coincides with the strategic plan of the imbb director john vontas an experienced researcher in chemical insecticides currently coordinator of two horizon2020 and several industrial projects this project is aligned with his green biotechnology sustainable development goals and the ris3 of the prefecture of crete in a region where agriculture and tourism are the main pillars for the economy microbiopest will be supported by structural reforms such as i the establishment of a biosafety level 3 bsl3 lab for work with vector pathogens ii the allocation of space within the 60m investment by the ebi for research training and innovation center for hosting the sustainable biotechbiopesticide center biopest that will evolve from microbiopest and iii operational procedures that will strengthen the technology transfer capacity of imbb the project will form a powerful and inspiring example of brain gain for the broader eu it will train and educate young scientists towards pragmatic career prospects in academia and industry it will form a unique scientific niche in greece with significant impact on the society via tailored communication platforms for target groups and offer alternative ecofriendly solutions to control insect pests
iprolepsis psoriatic arthritis inflammation explained through multisource data analysis guiding a novel personalised digital care ecosystem

psoriatic arthritis psa is a chronic progressive inflammatory disease affecting 12 of the general population while manifesting in up to 30 of people with psoriasis pso the transition from health to psa is currently untraceable diagnosis of early psa is challenging even in pso patients untimely diagnosis is common and contributes to early deterioration of quality of life also increasing the burden of the multiple comorbidities associated with psa in this vein iprolepsis aspires to shed light upon the healthtopsa transition with a comprehensive multiscalemultifactorial psa model employing novel trustworthy aibased analysis of multisource and heterogenous ia indepth health environmental genetic behavioural data digital phenotyping of inflammatory symptoms with emphasis on tracking of motor manifestations using smart devices and wearables novel optoacoustic imagingbased markers of psa in the skin and joints and investigation of the role of mast cells in the psa transition to identify key drivers of the disease and support personalized models for psa riskprogression prediction and monitoring as well as associated inflammation detection and severity assessment to ultimately advance psa diagnosis and care the models will be translated into a digital health ecosystem comprising dependable tools for supporting healthcare professionals in disease screening monitoring and treatment via quantitative explainable evidence and empowering people withat risk of psa with tailored insights and preventive interventions based on actionable factors for educated health management the project will steer its research and development efforts following a trustworthy framework for ethical lawful and robust ai and a usercentered cocreation approach based on constant involvement of key stakeholders during the design development and testing of the digital health ecosystem securing successful integration of the latter in the continuum of care
transition metal carbides decoration of 3d graphene nanostructures for enhanced electrocatalytic hydrogen production carbodoh2

the exhaustible nature of fossil fuels places our society in seek for alternative and renewable energy carriers hydrogen has attracted significant attention as it holds the highest specific energy density of any known fuel in addition it is a clean fuel that whose consume produces only water electricity and heat water splitting through electrolysis is an environmentally responsible carbonfree alternative technique for hydrogen generation water splitting takes place in an electrolytic cell or electrolyzer the hydrogen evolution reaction her and oxygen evolution reaction oer occur at the cathode and the anode of the cell producing gaseous hydrogen and oxygen molecules respectively heterogeneous electrocatalysis is a process that can accelerate these electrochemical reactions on the surface of catalysts materials for the production of h2 the design and development of efficient catalysts towards the her is of fundamental importance up today noble metals of the platinum group eg rh pt ru are the most attractive electrocatalysts for her nevertheless the high cost and scarcity of these materials limit their potential applications earthabundant transition metals tm based catalysts also show great potential for the her especially transition metal carbides tmc are very promising materials for this application thanks to their performance and availability in order to increase h2 generation per electrode surface area it is beneficial to engineer catalysts with high active surface area offering an increased amount of active sites the present project is prepared placing this necessity in its core and aims towards the design of novel nanostructured tmcs which can exhibit a very efficient activity towards the her to address this challenge we propose a novel synthetic approach which promotes the preparation of nanoengineered tmcs films standing on graphenebased highly conductive templates that exhibit very high active surface area
regulatory sandbox for a trustworthy artificial intelligence

ai applications are on the rise this is the case in terms of both number and value and is coupled with a prominent eu investments in the field and in related research aidriven innovations promise great benefits but also come with clear and concerning risks for data protection that are hard to predict and onlypartially covered by gdpr there is an urgent need to understand if and how regulators should intervene in this clash between ai innovations and data protection regulatory sandboxes are the perfect tool for doing so a regulatory sandbox can be defined as an environment for the testing of innovative products services or processes by selected private actors under the supervision of a regulatory authority their findings can be used to improve future regulation andor support compliance with current regulation rebootai aims at designing a legal theoretical framework to support member states and their data protection authorities in setting up regulatory sandboxes dedicated to the development of trustworthy ai applications this framework will be easily accessible in the form of recommendation guidelines which will be based on both theoretical and empirical research for that purpose the project studies the only two regulatory sandboxes in the european economic area that explicitly address the interaction between ai and data protection those that have been activated by the norwegian data protection authority and the french data protection authority by setting a standard framework for regulatory sandboxes on ai and data protection rebootai will bring about an increased adoption of ai trustworthy applications across europe thus significantly contributing to the horizon europe action horizoncl42021human0102
forcefree microstructures host intrinsic dynamics of orbital phases in av3sb5 kagome metals

electron correlations significantly modify electron selforganization in quantum materials resulting in a landscape of competing orders and exotic quantum phenomena the recently discovered av3sb5 family kagome superconductors is an intriguing example of competing correlated orders with robust entanglement as manipulating one order can affect or modify another akin to the unique electromagnetic responses of multiferroics these strongly entangled orders have led to an exciting hypothesis of orbital loop current a prime example of correlationdriven electronic instabilities nevertheless it renders the inherent characteristics practically inaccessible through conventional means as even slight variations in experimental conditions can significantly affect their physical properties our research plan is to examine the novel electronic response of the hypothesized orbital loop current in av3sb5 we will research the intrinsic dynamics of orbital phases and their unique electronic response via 1 atomically engineering the kagome nets with the comprehensive material database serves as the kagome toolbox 2 heatelectric quenching of charge order for effectively tuning the interlayer coupling in a kagome glass state 3 spatial control of chiral domains with optical polarization representing three unambiguous routes for revealing the intrinsic electronic orders in av3sb5these goals are ambitious yet entirely realizable freekagomes research approach is based on a unique forcefree setup that features controllable mechanical and thermal coupling between the focusedionbeam fib fabricated microstructure and its supporting frame based on the extremely soft membrane springs with designed geometry