Dragon09/odtu_chatbot huggingface dataset:
causative link between respiratory syncytial virus and chronic lung diseases identifying targets for therapy

chronic respiratory diseases are noncommunicable diseases for which infections by several respiratory viruses and human genetics constitute major risk factors the molecular and physiological mechanisms of how these viral infections cause and contribute to noncommunicable disease development are unknown respiratory syncytial virus rsv is a virus that infects nearly all infants before the age of 2 years and that is linked to asthma development we propose an integrative approach to identify genetic risk factors and mechanisms underlying virusinduced asthma specifically using two national cohorts estonian and spanish we will identify human genetic risk factors and rsv strains that contribute to severe bronchiolitis we analyse how rsv perturbs intracellular networks to change cellular properties that trigger asthma development we will use artificial intelligence aibased techniques to integrate generated data with the current biological knowledge to generate rsvinduced perturbation signatures and to identify druglike compounds able to revert the effects of the rsvinduced perturbations we will validate both mechanisms and candidate compounds in patient derived airway organoid models and when promising in a controlled human infection model trial clarity will impact the understanding prevention and possibly treatment of virustriggered asthma the results will enable development of a genetic risk score for longterm asthma development that enables personalised prevention campaigns which will be developed jointly with patient groups the molecular mechanisms discovered and the druglike compounds that revert the perturbation signatures will enable development of mechanismtargeted drugs fundamentally the mechanisms identified in this specific model for a strong viral contribution to noncommunicable disease will likely represent general mechanisms of how viral infections cause onset and development of other noncommunicable diseases
measuring the value of the key performance indicators kpi of the 2zero partnership

the 2zero partnership kpis are multiple and various relating to the threelayer approach for the objectives of 2zero as expressed in its sria this proposed csa will determine a common framework for monitoring these multiple and various kpis including their sources methods and reporting formats it will generate values for the kpis and their expected variation for the coming decade based upon the results of the projects being conducted within the partnership and the assessment of the impact of these projects results the proposed csa will support the identification and quantification of all interactions impacts and effectiveness of the partnership within the road transport challenge furthermore the proposed csa will provide recommendations for development and analysis of the means of measurement and evaluation of the partnership within the road transport challenge finally the csa will disseminate and communicate its results to a wide range of stakeholders throughout the road transport sector but also across member states and to the public in general via a range of media and events the consortium undertaking the proposed csa represents many sectors of the road transport community from multiple european countries it will be guided by a strong advisory board representing a broad range of vehicle manufactures suppliers rtos operators and infrastructure providers as well as technology partnerships joint undertakings and other representative organisations within europe
sers tweezers enhanced by electrothermoplasmonic flow

direct quantification of dopamine neurotransmission is one of the unsolved problems that engaged scientific minds for the last fifty years such quantification is an extremely important tool to understand the underlying pathways that promote neurodegenerative diseases like alzheimers and depression since dopamine is secreted only in micromolar quantities a novel signalamplification technique is required to be able to appropriately quantify its concentration to meet the challenge we propose a multidisciplinary research program comprised of simultaneous measurements from laser tweezer raman spectroscopy and fluorescence emission spectroscopy our proposal is based on the strong plasmonic interaction between graphene oxide nanosheets and aptamer functionalized gold nanoparticles which increases the local intensity of the electromagnetic field to an extent that minute changes in ambient dielectric constant due to variations in the concentration of dopamine could bring about a perceptible signal in the suggested scheme we will use optical tweezers to place a gold nanoparticle dimer close to the surface of a graphene oxide sheet and their hybridization will give rise to very strong electromagnetic fields able to dramatically increase the optical emission from dopamine moreover we will increase the local concentration of molecules with electrothermoplasmonic flow towards the sensing area the serset project will be carried out in the nanoparticle trapping lab at the university of granada where a stateoftheart setup combining optical tweezers and confocal raman spectroscopy is available a microfluidic chip and theoretical calculations will be carried out in the group of prof romain quidant at eth zurich during the planned secondments the candidate has a strong background in nanoparticle synthesis plasmonics and computational modelling which will be combined in the present proposal to bring about a new technology able to quantify dopamine secretion
a minimally invasive surgical platform against pancreatic and biliary tract cancers using cold atmospheric plasma

cancer is one of the major causes of death in europe pancreatic pc and biliary tract btc cancer are rare gastrointestinal adenocarcinomas with an increasing incidence particularly among the elderly and women in an ageing european population and a poor prognosis poses major clinical challenges and public health burden cold atmospheric pressure plasma cap has shown potential regressing various cancer types in the laboratory setting owing to their properties cap is a unique source of high concentrations of reactive radicals electrons ions uv etc that may induce various effects in living tissue cap has shown selectivity in where cancer cells are treated with minimal effect to healthy ones this renders plasma suitable to treat carcinomas in very sensitive areas or organs where an unmet need to minimise damagesideeffects exists cap can be delivered through dielectric tubes of variable length which makes it ideal for minimally invasive and precise laparoscopic and endoscopic operations despite the great promise and potential of this concept there is no single laparoscopic or endoscopic medical platform in the market today based on cap to treat carcinomas this project proposes a novel solution using cuttingedge plasma technology insilico models and a systemlevel approach it will combine plasma with tumour multiscale simulations and will take input from presurgery diagnostics for insilico model initialisation and cap operational window determination the developed technology will be demonstrated through invivo experiments while the foundations for clinical trials and market introduction for capbased care of pcbtcs will be laid out in this project
increased flexibility of atco validations v3

growing traffic numbers environmental aspects and cost effectiveness issues create a huge demand on the air traffic management to continuously optimize its processes and use of resourcesone key resource is the availability air traffic controllers of the air navigation service providers due to current regulations and practices the deployment of air traffic controllers to a specific airspace or unit is restricted by unit endorsements as controllers have to be comprehensively trained on local procedures and circumstancesthe research proposed in this project aims at enabling a more flexible deployment of atcos to sectors this is a very wanted and eagerly awaited improvement in atm because it would improve its cost efficiency by millions of euros that could be saved yearly in the european union the concept behind increased flexibility of atco validations ifav are various flexible endorsement strategies that are based on technical enablers like specific controller assistance systems that provide support on sector specific procedures and rules andor procedural enablers like for example atc task standardizationbased on prequel sesar solutions like pj3301ab and pj1073 ifav this new project will continue the ifav work done in upper area control and progress it to v3 trl6 maturity this will be the main part of the project in addition about 15 of the project will be spent to transfer the knowhow to another beneficial and similar use case the application of ifav in a remote tower centrethis project proposes two solutions that correspond to the described activities and will include eight validation exercises the consortium will consist of 13 partners 5 ansps 2 universities 1 big industrial partner and 5 research organisations most of the partners were involved in prequel solutions pj3301ab andor pj1073 ifav dlr will act as project coordinator
gender conflict and coercive control a feminist phenomenological expansion of conflictrelated harm

gencoerctrl is the first transnational empirical theoretical qualitative study of the gendered phenomenon of conflictrelated coercive control responding to flourishing multiinterdisciplinary interest in physical and sexual forms of conflictrelated violence against women crvaw over the last two decades it reorients scholarship towards the less observationally evident harm of coercive control preliminary evidence shows that in conflict settings women may experience coercive control in the context of informal armed group governance and through the coercive realities of conflict transition with transitional justice mechanisms critical to making such harms visible for engagement coercive control as an invisible but insidious harm and coercive control as a lens through which to understand womens experiences of conflict has received little to no scholarly examination gencoerctrl gets ahead of its pending travel into interdisciplinary fields on conflict violence by establishing the basis for the theoretical and empirical expansion of a new field of study of the gendered phenomenon of coercive control the central research question addresses the multidimensional nature of the coercive realities in which women experience coercive control in conflict and transition how is coercive control in conflictaffected contexts lived and understood by women for whom it is already coconstitutive of their socially coercive realities it is addressed across four phases development of a new feminist phenomenological methodology for studying the lived experience of the gendered phenomenon of conflictrelated coercive control generation of unique empirical phenomenological understanding of coercive control in colombia northern ireland and sri lanka analysis of transitional justice mechanisms in those sites through a coercive control lens synthesising to develop the first ecological framework for the gendered phenomenon of conflictrelated coercive control
personalizing the unconscious a cognitive neural and developmental investigation

consciousness is often described as the tip of the iceberg under which a rich unconscious world exists but is this metaphor accuratethe literature provides a mixture of contradicting findings with some claiming that almost any cognitive function can be performed without awareness while others arguing that unconscious processes are limited to routine simple operationscurrently there are two gaps in this body of knowledge though first the field has almost solely examined grouplevel findings without taking individual differences into account second it is based on studies probing specific processes at specific time points no study to date has tried to take a more global approach looking for common mechanisms that persist over time and potentially over taskshere i aim at bridging over these two gaps providing a novel framework i suggest that individuals consistently differ in their susceptibility to unconscious processing sup i hypothesize that sup is a stable trait that can explain conflicting findings and shed new light on the interplay between conscious and unconscious processes starting with a task for which evidence for stable individual differences exist i suggest three possible neural mechanisms that can explain such differences these mechanisms will be tested using electrophysiology neuroimaging and developmental studies i also introduce a novel protocol for pitting conscious and unconscious processing against each other and biasing this competition via feedbackfinally i will conduct a largescale study testing the riskier hypothesis that sup might not only be stable over time but also across taskstogether this study will provide a much needed unparalleled systematic investigation of the reliability and replicability of key findings in the fieldthis research strives for a paradigmatic shift in the way we conceptualize study and utilize unconscious processes laying the foundations for a new science of the unconscious
deciphering the role of immunoglobulin classes in shaping follicular lymphoma molecular heterogeneity and evolution

follicular lymphoma fl is the second most common b cell neoplasm characterized by the t1418 chromosomal translocation resulting in deregulated bcl2 oncoprotein bcl2tx in situ follicular neoplasia isfn represents an early precursor lesion histologically identified as bcl2cd10 germinal centers gc that might progress into fl spatial and temporal genomic analysis in fl revealed that its transformation into aggressive highgrade mycbcl2 doublehit lymphoma dhl arises predominantly from a common precursor that clonally diverges upon the acquisition of genetic hits through iterative gc transitions expansion of fl b cells requires the presence of a functional b cell receptor bcr which can be expressed in either unswitched immunoglobulin m igm or switched iggiga isotype preliminary data from the hosting laboratory showed an isotypedependent regulation of ig levels in fl and mycbcl2 dhls prompting the hypothesis that specific igh classes may differentially impact pretumoral fl lesions shaping the transforming trajectory of isfn cells overt fl cells and finally giving rise to dhl using stateoftheart technologies including singlecell and spatiallyresolved transcriptomics and genetics analyses i will define ighclass dependent transcriptional changes in the transition from isfn to fl and eventually dhl and the influence of specific isotype to shape intra and inter tumor heterogeneity and tumor mutational landscape finally i propose to determine whether the immunoregulatory activity of tumorinfiltrating immunestromal cells is influenced by the expression of defined igisotypes in lymphoma cells overall this action will establish previously uncharacterized roles for distinct igh classes to determine transforming trajectories promoting the transformation of bcl2tx gc b cells into first fl and later dhl providing novel clinically relevant biomarkers predicting patient outcome and tumor evolution
mapping the connectome dynamics of trauma psychopathology

exposure to a traumatic event can induce psychophysiological reactions and symptoms that in most people recede over time a minority of traumaexposed individuals develop posttraumatic stress disorder ptsd characterized by severe functional and emotional impairment the global burden of ptsd is estimated in the hundreds of billions of euros and millions of years lived with disability individual differences in neurobiological vulnerability to traumatic stress have been studied extensively yet the impact of neuroscience on clinical application is minimal the proposed work aims to address this gap using three work packages wps wp1 will establish a detailed openaccess database to study the impact of traumatic stress on brain structurefunction connectome 1000 participants with ptsd 1000 traumaexposed healthy 1000 nonexposed wp2 is a longitudinal study of the effects of trauma exposure it will delineate longterm trajectories of stressrelated symptoms and corresponding connectome dynamics building on already collected data from 579 veterans who were followed over four years starting with a preexposure baseline we will add two new data points at 7 and 9year postexposure to reveal longterm adaptation patterns wp3 is a 3armed randomized controlled trial to test the impact of mriguided neurostimulation of corticohippocampal networks on brain connectivity patterns and severity of memory symptoms we target corticohippocampal connections with broad impact on cortical circuitry consistent with our focus on wholebrain connectome correlates moving beyond separate analyses of brain structure and function in relation to a heterogeneous definition of ptsd we will use combined structurefunction modeling in relation to specific symptoms together the proposed work is expected to redetermine the transaction between neuroscience and clinical research in relation to trauma psychopathology
ethics and regulatory capacity building partnership for clinical trials in portuguesespeaking african countries

ctluso intends to 1 draw an updated diagnosis and screenshot of the research ethics infrastructure in the 5 portuguesespeaking african countries psac 2 identify the needed transformations draft strategic recommendations to carry out this transformation and design a policy roadmap for its implementation 3 reinforce existing legislation and promote the necessary regulations for a robust ethicallegal framework supporting the revision of internal regulations for the operation of recs and nras and promote the development of codes of scientific integrity in research institutions 4 strengthen the skills of recs and nras researchers senior junior and postgraduate students by drafting guidelines for the practice of the different roles required by the evaluation of ctsit is necessary to work with all 5 psac simultaneously on four different levels all equally indispensable and complementary legislative institutional professional and procedural which in turn requires political commitment ctluso proposes to reach the abovementioned objectives by 1 building an international team of legal experts and promoting dialogue for the cocreation of legislative and organizational recommendations 2 creating an interdisciplinary and crosssectoral education 3 creating an advanced progressive training program for members of recs nra cts centres and researchers 4 handson experience developed in a finely tuned manner and according to country specificities complementing the previous education and training programs 5 assess whether each psac has the necessary installed capacity to be included in the international cts roadmap and in particular to create a portuguesespeaking cluster by simulating the procedures under the development of an academic ct 6 in parallel the legislative and regulatory transformations to be implemented will require the political power involvement acting in a double approach both bottomup and topdown
targeting acute leukemia with tdttcrtcell therapy

the aim of this poc project is to commercialize new therapy for acute lymphoblastic leukemia all developed in context of my erc consolidator grant tcell receptors tcrs have in recent years emerged as promising therapeutic molecules in cell and genetherapy of cancer i have completed the preclinical validation of a tcr that recognizes an hlabound peptide from a novel target the nuclear enzyme terminal deoxynucleotidyl transferase tdttcr in vitro and in vivo data from four different mouse models show eradication of all and no indications of toxicity tcells genetically modified with the tdttcr effectively kill lymphoblastic cancer cells while sparing healthy b and tcells myeloid cells and hematopoietic stem cells funding has been secured for an investigatorinitiated trial to determine safety and explore efficacy of tdttcrtcell therapy ttttherapy the trial will recruit all patients relapsing fromrefractory to standard therapy who have a dismal prognosis and thus a great unmet medical need to facilitate commercial development i have created a startup company and secured the company exclusive licenses for the patents on the tdttcr and the technology used for the development on which i am the main inventor in the proposed erc poc project i and my strong team of advisers with expertise in the business development clinical development ipr and financial aspects needed for commercialization will conduct a market analysis for ttttherapy and develop an ipr and business strategy for the startup company since several studies report expression of tdt in acute myeloid leukemia aml i will conduct laboratory research to determine if the tdttcr can also mediate killing of aml cells aml patients have an overall 5year survival of only 30 and hence a great medical need that potentially could be met by ttttherapy the described work has the potential to contribute to saving lives that would otherwise be lost to acute leukemia
innovation nexus

it is widely acknowledged that higher education institutions heis should go beyond their traditional education and research functions and also be key actors in promoting creating and sustaining social innovation that responds to multifaceted challenges social innovation has gained relevance within the framework of academia at the international level although is recognised the need to enable social innovation ecosystems across europe through the adoption of systemic solutions involving diverse actors institutions and places involving allkind of social innovation actors social innovation actorssocial entrepreneurs smes startups accelerators and business incubators investors industry foundations philanthropy societies heis and rtos publicowned enterprises hence innovation nexus starts from a clear commitment from the participating heis to balance the fourth helix by increasing the role of heis as drivers of social innovation but in coconstruction with other stakeholders from across the fourth helix specifically a methodology consisting of two distinct but complementary phases has been defined in the first phase the focus will be on innovation actors and on building capacity among them so that they become better equipped to work with social entrepreneurs in the second phase the focus will be on social innovation actors and on their access to the resources of innovation ecosystems