Dragon09/odtu_chatbot huggingface dataset:
engineering of new 2d materials phases not existing in nature

2d engine targets new 2d materials phases that do not exist in nature in bulk but that can be engineered by synthetic techniques in thin film form the new 2d phases emerge from their 3d polar parent materials with the wurtzite structure and stabilize below a critical thickness a few ml as a result of surface energy minimization adopting a planar nonpolar hexagonal h bnlike structure the new materials exhibiting sp2 hybridization are expected to have the stability of graphene but also possess a finite energy gap that makes them useful for optoelectronic devices haln 2d dielectric as well as hgan and hsic 2d semiconductors are targeted with the aim to fabricate functional electronic and photonic devices first as a means to validate the quality of these materials at the highest possible level second to show that the new 2d phases could have an impact addressing urgent needs in digital and si photonics technologies moreover 2d engine aims to show new functionalities such as nanoscale ferroelectricity produced by twisted bilayer haln or hbn which can lead to ultralow power ferroelectric tunnel junction memristors for inmemory computing to implement the objectives we will base our growth methodology on liquid metal catalyst lmcat substrates to achieve seamless merging of small islands to largerarea single crystals in the mm scale highsensitivity synchrotron xrd surface analytical techniques raman spectroscopy and radiationmode optical microscopy will be employed for real time operando monitoring of growth and for the unambiguous identification of the new 2d phases at the atomic scale supported by atomistic simulations and aiassisted data analysis the necessary process modules will be developed with an emphasis on roboticarmassisted direct separation layer twisting and transfer in order to assemble the device layer stacks for further processing of nanoscaled 2d transistors and integrated 2d ledwaveguide systems
quantum computational fluid dynamics

scientific and technological progress is broadly underpinned by the ability to accurately predict and optimise complex fluid flows which arise across the physical and life sciences including climate research as well as in the energy chemical automotive aircraft and ship building industries the wide separation of length and time scales that need to be covered when designing and optimising flows and a large number of design parameters make numerical simulations highly demanding current capabilities are thus insufficient to meet future demands of users in academia and industrywe will tackle this challenge by developing a quantum software framework for solving a wide range of industrially relevant computational fluid dynamics problems this will consist of platformindependent quantum algorithms and hardware optimized software for platforms in the european quantum technology flagship projects tensornetwork simulations gatelevel classical simulations including realistic quantum noise models and implementations on quantum hardware will provide detailed information on quantum hardware requirements achievable quantum advantages and provide feedback to hardware developers the quantum software will be verified and benchmarked against standard computational fluid dynamics results it will be developed in agile cycles to respond quickly to user demands and progress in the quality of quantum hardwarewe will demonstrate the feasibility and advantages of the quantum approach starting from a core set of highly scalable and industrially relevant design examples arising in the thermal management of batteryelectricvehicles aimed at increasing their efficiency subsequently we will extend our approach to a wider class of fluid flows and industry partners we will create an interface between the quantum software framework and the industry standard computational fluid dynamics software openfoam to make it widely available and maximise its impact
developing novel singlecell technologies to model and perturb intratumor interactions and signaling an innovation program for the next generation of immunotherapies

singlecell genomic technologies have transformed many fields of research we here seek to do just that in syntheticimmunology and immunotherapy at present our understanding of the complex crosstalk within the tumor microenvironment tme is still piecemeal as is our ability to effectively engineer the immune system to attack tumor cells in spite of the robust immunesuppression signaling of the tumor in line current immunotherapies are effective only in a small subset of tumor types and patients emphasizing the dire need to better understand immunesuppressive mechanisms within the tme and develop new immunotherapy strategies what if we could develop technologies that reprogram the immune system to suit our therapeutic needs in trojancell we will do so by first uncovering fundamental principles of the immunetumor niche using advanced singlecell multiomics tools and modelling approaches this will then serve to develop trojancella novel synthetic immunology technology for engineering circuits capable of sensing inhibitoryimmune signals and generating a proportional selfregulated immuneactivation responsethus using the tumors own procancer signaling to eradicate it in obj1 we will dissect the principles of the inhibitory crosstalk and signaling in the tme of diverse human tumors using our singlecell technologies picseq and insseq in obj2 we will screen and develop mice tumor models that recapitulate the human tme which we will use to define the function of factorscircuits of interest in obj3 we will develop trojancell a novel toolset for transforming tumor inhibitory signals into potent highly specific antitumor immunity our research will greatly expand our understanding of the immuneinhibitory crosstalk in the tme and give rise to novel immune engineering approaches and molecules which may serve as the next generation of cancer immunotherapies
magnetic 3d nanowire networks

the scope of this marie sklodowskacurie action is contributing to achieve a priority goal for the european commission the development of resilient materials for space technology thus enabling it to achieve a leading position for the european aerospace industry in february 2022 the eu parliament flagged that europe was critically lagging behind in space technology and market uptake competition nowadays the eu is facing the consequences of geopolitical dependencies in energy semiconductors and access to space space environment is harsh and pushes devices to the limits of radiation tolerance temperature swifts and mechanical loads moreover electronic devices in payloads and platforms must be lightweight and low volume in addition they shall not interfere with other sensitive electronic equipment by their own electromagnetic emissions three dimensional 3d magnetic networks have the potential for a highly performance longlife and lightweight solution however precise fabrication of 3d magnetic metamaterials is expensive and hardly scalable to overcome these challenges we propose to use magnetic 3d nanowire networks fabricated by electrodeposition in selfassembled 3d alumina templates the midas project magnetic 3d nanowire networks envisages the capacity to decrease and even suppress the electromagnetic interference emi and to improve the electromagnetic compatibility of space electronics by developing space robust absorbing 3d metamaterials able to be conformal to aluminum chassis simplifying their practical implementation and integration within the structures to achieve so dr l g vivas will receive handson training in complementary experimental techniques at the host group of prof m martingonzalez at the institute of micro and nanotechnology and the secondment group of dr r sanz at the national institute of aerospace technique
twinning greenediting vibes for fd

credit vibes presents a cloud of creativity research education development innovation and transformation credit where the training of the highlyskilled researchers and nonresearch staff is the priority credit vibes are launched healthy foodfeed a healthy ecofriendly environment and healthy life on a healthy planet it was guided by the idea that if maize research institute from serbia is structurally transformed and thus improved transfer of agrotechnology and agroknowledge and increase number of manageable projects other institutions in serbia and the region will copy that pattern and enhanceself when several smaller microtransformations come together the communitys interest rises to the global level and excellence is born the main projects objectives are to transform and access excellence following the scientific and technology roadmaps and thus extend networking and collaboration in the region and europe research area credit vibes expects broader scientific economic and societal effects in raising the excellence of maize research institute which will open new science pathways and thus increase the number of manageable projects furthermore increasing the transfer of agroknowledge and agrotechnologies into the economy by 15 will be the main longterm propeller of economic growth
farinfrared to radio search for distant dustobscured galaxies and structures

we are at a tipping point where unveiling the nature of distant dustobscured galaxies and the formation of the first protoclusters in our universe is finally possible thanks to recent advances in multiwavelength astronomy taking advantage of a unique ensemble of deep largearea data sets from the farinfrared fir to radio wavelengths in the cosmos and h20 fields i propose the project firstdust farinfrared to radio search for distant dustobscured galaxies and structures that will provide a complete characterization of the dustobscured starformation rate density sfrd at z 26 and robust constraints on the contribution of previously undiscovered galaxy protoclusters to the sfrd firstdust will also deliver the census of dusty star forming galaxies and protoclusters providing invaluable targets for the upcoming nextgeneration telescopes eg jwst eelt i have unique expertise on producing multiwavelength photometric catalogs by synthesizing data from ir and radio telescopes and sophisticated data processing and measurement skills with submm interferometry alma noema and atca g magdis group at dtu space has exclusive access to jwst miri gto data and unique expertise to support the analysis with the firsubmm data the cosmic dawn center dawn has been constructing the largest exclusive access data sets in the ir side and leading the 50 square degree dawn survey which is essential to this project my dedicated work at dtu dawn is thus the best synergy to realize the proposed project
antenna systems experts for 6g nonterrestrial networks

our society is on the brink of a new age with the development of new visionary concepts such as internet of things autonomous driving and coverage everywhere this stimulates the use of new deployment concepts such as nonterrestrial networks ntn to support the wireless communication evolution for 6g a key use case which stands unaddressed by prior telecommunication generations is that of coverage everywhere a major candidate to solve this issue is to deploy a network of satellites in an ntn configuration which is front hauled by a highgain gateway cell in order to serve rural and remote areas which up until now is lacking coverage here especially novel energy efficient antenna systems are required to track fast moving satellites while meeting the cost targets of the consumer market one of the major reasons for not addressing this thus far is the lack of expertise about nonterrestrial communication in the classical terrestrial telecommunication industry which underpins the urgent need for a crossdisciplinary industrial doctorate networkanterra establishes a unique and wellstructured training network with leading rd labs from european industries universities and technology institutes in the domain of antenna systems for terrestrial as well as nonterrestrial applications the 15 esrs will form a research team that is embedded in leading industrial and academic rd labs the programme will strongly enhance the employability and career prospects of the esrs by offering a highquality consortium with indepth training in the technical areas as well as a comprehensive set of transferable skills relevant for innovation and longterm employability the esrs will all spend at least 18 months of their time at industry ensuring that the training includes a significant industrial experience and application
principles of endogenous and therapeutic mrna turnover in vivo

during the covid19 pandemic we witnessed the application of mrna vaccines for sarscov2 paving the way for the widespread use during the covid19 pandemic we witnessed the application of mrna vaccines for sarscov2 paving the way for the widespread use of therapeutic mrnas in medicine however lack of knowledge regarding mrna metabolism in vivo limits the optimization and refinement of such therapies our preliminary data acquired via direct rna sequencing drs shows that variability of polya tail length and therefore stability of endogenous and therapeutic mrnas in different tissues and cell types is much larger than previously thought here we propose the viverna project which will enhance the drs edrs pipeline and combine it with analyses of mouse models primary cell cultures and synthetic biology approaches to examine the nature of mrna turnover in vivo and characterize the metabolism of endogenous and administered mrnas the goal of the viverna project is to elucidate the complexity of mrna lifetime regulation specifically our aims arepart 1 construction of an enhanced nanopore direct rna sequencing pipeline edrs for comprehensive analyses of mrna metabolism edrs will assess the composition and lengths of polya tails modifications isoforms and dynamicspart 2 comprehensive analysis of the lifecycle of endogenous mrnas analyzing dynamics ribosome association and polya tail metabolism in organs and primary cells and providing insights into the role of particular enzymes the reach data resource will help designing better mrna therapeutics and enable the formulation of testable mechanistic hypothesespart 3 description of the metabolism of therapeutic mrnas in relevant cell types and tissues then together with the knowledge gained in part 2 the design of more stable mrnas with therapeutic potential will be initiatedthe viverna project will facilitate the rational design of nextgeneration mrna therapeutics
a new paradigm in agrochemistry by manipulating structural bulk

the advent of agriculture has played a decisive role in humankinds ability to create localized settlements which has consequently led to the development of complex societieswith increases in human population the need for reliable largescale agriculture grew sustenance of modern society is a significant societal challenge and relies heavily on two factors fertilization and crop protection while the haberbosch process and related concepts have contributed to solving the former crop protection remains a key issue significant innovation in many key areas is necessary to enhance the effectiveness of crop protection as the invention of economically viable processes for the creation of novel types of crop protection agents will play a decisive role in enabling agriculture to sustain the worlds populationin a project supported by the erc cog vincat nuno maulide and his group at the institute of organic chemistry university of vienna austria have made groundbreaking discoveries that could significantly impact the production of agriculturally relevant compounds the goal of the erc poc project agrosterics is to implement this technology to ultimately demonstrate its efficacy and to develop an appropriate market analysis and ip strategy
dynamical control of spintronic devices through solidstate gating

the increasing dependence of everyday life on digital technologies raises challenges for materials science data is becoming one of the most precious assets of modern society and its storage and processing require more and more electrical power in order to keep this energy consumption under control new technologies are emerging that shift the paradigms of computation among these the field of spintronics holds potential to meeting the current requirements of dense nonvolatile data storage and logic technology in which information can be written manipulated and read as efficiently and as fast as possible the main goal of the spindy project is to develop innovative and sustainable spintronic devices the basic concept behind my proposed approach is to use solidstate gating to act on the device structure during operation and thus tune its functionality dynamically this will allow to perform lowpower reading and writing operations without compromising the stability of the device for longterm information retention i will implement this working in two parallel directions the first is by achieving voltage control of orbital currents in light transition metals which in turn allows to tune the torque efficiency at the interface between the metal and a magnetic material the second is by manipulating the magnetic properties of a rareearthfree ferrimagnetic layer through electrical gating finally i will combine aspects of both approaches to develop proofofprinciple dynamical spintronic devices that can act as memory or for logic operations with enhanced performances in terms of energy efficiency and stability thanks to their tunable nature the main outcomes of the spindy project display aspects of great interest from both applied and fundamental points of view and thus will be highly relevant for the research community including disciplines beyond spintronics as well as have economical and societal impacts
therapies for renal ciliopathies

ciliopathies are a large group of rare and severe genetic diseases caused by dysfunction of the primary cilium a microtubulebased cell surface antenna that controls key signaling output required during development and tissue homeostasis cilium dysfunction leads to complex disorders with high genetic heterogeneity and overlapping phenotypes despite the broad clinical spectrum chronic kidney disease ckd leading to end stage kidney disease eskd is a common cause of morbidity across ciliopathies currently the only available standard of care for ckd is based on dialysis and transplantation renal ciliopathies represent a main cause of eskd during childhood and despite the identification of more than 40 causative genes it remains difficult to predict the severity of the disease as well as the risk of appearance if not present at diagnosis and the rate of progression of renal failure theracil therefore aims 1 to improve diagnosis and prognosis of at risk pediatric renal ciliopathy patients and 2 to implement therapeutic approaches aimed at targeting shared pathological pathways at modifying mrna targets of the causative or modifier genes by antisense oligonucleotides and by the repurposing of available molecules these goals will be achieved through the federation of our unique databases of pediatric renal ciliopathies cases available across europe which will allow a better stratification of patients the identification of modifier genes and markers of disease progression bioinformatics approaches will be used to integrate patients biological and genetic data as well as multiomics and functional analyses from patients samples and preclinical models these analyses should lead to the identification of shared targetable pathological pathways as well as of patients eligible for the identified new therapeutic approaches which will be evaluated in robust preclinical models
raman active smart diatom frustules as next generation multimodal theranostics for safe and superior colorectal cancer treatment

colorectal cancer accounted for 127 of all new cancer diagnosis and 124 of all deaths due to cancer in european union in 2020 despite the advances in therapeutics it is the most recurrent tumors in humans and third common cause of cancerrelated deaths worldwide the current treatment options include chemotherapy radiation and surgery that are invasive and have sideeffects also the 1st and 2nd generation nanocarriers used in cancer therapy consisted of monocomponent systems and failed due to lack of targeting molecules remotely controlled therapeutics window and patientspecific individualized platforms the project diashuttle aims to develop a novel nextgeneration smart multifunctional and multimodal hybrid nanotheranostic platform consisting of biosilica extracted from living diatoms for simultaneous diagnosis treatment and therapy monitoring of colorectal cancer it will combine magnetic nanoparticle core surface deposited metallic gold nanoparticles tumor targeting biomolecule folic acid and natural source drug astaxanthin to facilitate different modes of therapy such as magnetically guided or ligand targeted drug delivery magnetic hyperthermia and photothermal therapy it will also concurrently enable different modes of realtime monitoring such as raman surface enhanced raman spectroscopy magnetic resonance imaging fluorescence and photoluminescence it is expected that the combination of different therapies will exhibit superior synergistic anticancer effect over monotherapy and reduce treatment delays by offering a safe and personalized approach to overcome the limitations of conventional cancer treatment the proposed platform will lead to less toxicity due to the use of targeting molecule and natural materials controlled drug release and lower effective drug concentration additionally the nutrient uptake and co2 sequestration capability of diatoms will support circular bioeconomy and selfsustainability
revolutionary vascular repair patch to treat aortic dissections

aortyx has developed a biomimetic bioresorbable adhesive patch to treat aortic dissections it is inserted in the aorta through a femoral access using an endovascular catheter and a deployer the patch adheres to the aortic tear stopping false lumen blood flow and promotes natural repair and biointegration thanks to its patented microstructure and viscoelasticity current endovascular approaches use rigid grafted stents that have multiple drawbacks with continuing high mortality rates these approaches will be replaced by our viscoelastic biomimetic patch that has minimal sideeffects and promotes natural repair of the artery consequently our device will reduce adassociated mortality and improve postintervention life quality of patients it will also reduce postoperative stay and increase patient eligibility we seek eic accelerator funding to fund the testing that will prove the scalability of our solution and set us on the path to becoming a global champion of aortic devices