Dragon09/odtu_chatbot huggingface dataset:
a paradigm shift in health monitoring with electrospun enzymatic neomaterials

global healthcare associated with chronic nonhealing wounds can be considered a main public health problem as affects up to 2 of the world population a novel approach is needed mainly to support the quality of life of the people suffering from this silent epidemic and additionally alleviate the impact in costs and resources for the healthcare system up to date no smart bandages have made it to the real market and research state is still going on for a reliable and sensitive inspection method the main goal of woundsens project is to lead the development of a novel generation of wearable biosensors with a synergy of technological breakthroughs in transversal fields of knowledge sensor elements for the first time will directly become a compatible part of the wound dressing material itself resulting in enhanced wearing comfort and operability accordingly they will be integratable into manufacturers existing standard processes suturing embroidery rolltoroll our proposal presents a parading shift in smart wound dressings constructed on novel hollow fibers with radial biosignaling based on engineered novel enzymes woundsens presents a leadingedge new technology with the design and development of innovative electrochemical materials with step forward advances in conductive material the development of electrospun neofibers and processes with leading edge methodologies on electrospinning and the enzyme engineering of a new family of detection biocatalysts resurrected and extant enzymes to secure a sensitive and reliable signal woundsens proposal accepts the challenge of pushing forward the new technological platform to design a new concept in continuous wound control and monitoring improving the life of millions of people
protein function regulation through inserts for response to biological chemical and physical signals

we live in an era of profound excitement for synthetic biology which is providing insights into the underlying mechanisms of living systems and powerful tools to modify biological and biomimetic systems using innovative design principles regulation of protein function based on the recognition of other molecules or environmental conditions is fundamental to all living systems my vision and the strategic objectives of the project are to develop a modular platform that imparts proteins with the ability to sense diverse signals thus enabling the regulation of their function and the introduction of novel properties into biological systems this project aims to explore unique opportunities for regulating protein function through insertions leveraging modular building blocks with wellknown and tunable properties by combining these building blocks in innovative ways proteins and biological systems will be engineered to respond to biological chemical and physical signals the specific objectives of the project encompass 1 design protein responsiveness to ph and rna molecules generating rna sensors and regulating protein function based on cell type or statespecific rna molecules 2 enable proteins to sense the concentration of other proteins creating concentrationdependent regulatory circuits with a demonstration of biomedical application 3 construct de novo mechanoresponsive proteins to prepare genetically encoded mechanosensors tolerant to high forces and mechanoresponsive designs of car for cancer immunotherapy and 4 design new protein regulators with favorable in vivo properties and regulators of natural proteins through several compelling examples in mammalian cells this project aims to demonstrate the transformative potential of endowing proteins with unique and previously unknown properties advancing the engineering of biological systems and paving the way for potential therapeutic applications in the field of biomedicine
solar cycle prediction tool using solar internal oscillations sycos

short and longterm prediction of solar activity and space weather are longstanding problems affecting the society at a large scale being able to issue a prediction earlier and more reliably will prevent economic losses for industries space sector and governments during our ongoing erc cog project unisdyn we have numerically and observationally demonstrated the potential of a novel data product the internal surface gravity oscillation mode tracing the subsurface magnetic field in the sun and here formulated methodologies to build prediction tools based on it both over short and long timescales earlier prediction methods have relied on magnetic fields on the solar surface or in the interplanetary space while now we propose to use the solar internal oscillations as basis of the predictions hence our ideas are novel and groundbraking innovation potential is augmented by the demonstrated capacity of the team to perform the demanding data analysis of the required data products for the proofofconcept tools large innovation potential is also contained in new type of data service to be built they augment the sustainability and reusability of generic scientific data products and enhance the renewal of science
integrated aidriven systems for kidney transplant precision medicine aicare

despite considerable improvements in shortterm allograft and patient survival in kidney transplantation in the past two decades longterm graft survival remains low with 20 of transplants failing within five years rejection remains a leading cause of graft loss with immediate consequences for patient morbidity and mortality posing a major burden on healthcare systems increased allograft longevity requires improved patient monitoring and rejection risk stratification using mechanistically informed noninvasive biomarker strategies and precision diagnostics the main limitation for such an endeavor is the lack of deeply phenotyped cohorts given the complexity and heterogeneity of allograft rejection patient cohorts with sufficient volume velocity variety and validity of data are critical in order to capture disease activity disease stage improve risk stratification and optimize treatment another limitation is the paucity of multidimensional and integrative research strategies the goal of the erc aicare project is therefore to go beyond the current state of the art by establishing a transplant precision medicine system to 1 facilitate personalized noninvasive patient monitoring using cellfree dna technology liquid biopsy 2 improve rejection diagnosis beyond conventional histology using molecular technologies and digital pathology and 3 gain further mechanistic insights and improve diagnostic accuracy of transplant organ diseases and apply this knowledge to new research areas
achieving good environmental status for maintaining ecosystem services by assessing integrated impacts of cumulative pressures

ges4seas will inform and guide marine governance in minimizing human pressures and their impacts on marine biodiversity and ecosystem functioning while maintaining the sustainable delivery of ecosystem services this will be achieved through developing an innovative and flexible toolbox tested validated demonstrated and upscaled in the context of adaptive ecosystembased management ebm this will allow competent authorities to assess and predict the effect of multiple stressors including climate change and pressures from human activities at the national subregional regional and european level this will ensure they achieve good environmental status msfd and support different policies at national european and global levels eg bhd biodiversity strategy sdg this will be achieved by integrating stakeholders and the key competent authorities in a practitioner advisory board in cocreating and validating the toolbox and the ebm approach in this we focus on real problem solving and following an iterative and incremental development approach this will allow ges4seas to achieve technological and societal readiness levels 6 since our solutions will be tested and demonstrated at 11 learning sites lss covering important regions and environments these lss have been selected to explore geographical specificities in the four regional seas with regards to the impacts of cumulative pressures including climate change on the functioning of ecosystems and their capacity for providing ecosystem services to ensure better management this includes lss to explore transboundary issues and a ls at paneuropean scale to explore comparability and harmonization across regional seas and gain understanding on the functioning of transverse topics eg invasive species habs and jellyfish blooms and top predators finally to internationalize outputs we have included a ls in the caribbean sea in relation to the sdgs framework and intense extreme events
selfsabotage in the early mammalian embryo investigating the interplay between dna damage responses splicing failure and zygotic reprogramming

in mammals oocyte fertilisation is followed by a dramatic epigenetic and transcriptomic reprograming to prepare the newly formed embryo for subsequent development preserving genome integrity is critical at these early stages when all cells have the potential to contribute to a large proportion of the embryo including the germ line despite this work by ourselves and others suggests the atm kinase driven dna damage response ddr to double strand breaks is dampened in the early embryo at the same time the atr kinase mediated ddr appears fully active and may even function in zygotic reprograming as dna damage acting through this pathway can reprogram embryonic stem cells to a more totipotent state reminiscent of the early postfertilisation embryo beyond this little is known about ddrs in the early embryo however we have recently identified a programmed splicing failure that accompanies the transcriptomic reprograming of the embryo and disproportionately disrupts transcripts coding for ddr genes furthermore splicing inhibition has been found to reprogram embryonic stem cells to a more totipotent state and we have found this also inordinately disrupts ddr gene transcripts these findings raise three fundamental questions i why is a dampened atm dependent ddr found in early cleavage stage embryosii does an atr mediated ddr play a role in embryonic reprograming and totipotency emergenceiii what is the impact of the programmed splicing failure on embryo development and totipotency and is it related to ddr regulationwe will take a multidisciplinary approach to answer these questions using a combination of highthroughput omics and focused techniques in the early mouse embryo the knowledge gained will represent a breakthrough in the understanding of early mammalian postfertilisation development allowing us to unravel the interaction between the unique cellular processes that occur at this time genome integrity control and splicing failure
migration waves and their contributions to economic and political institutions in origin countries

the ongoing global migration crisis has emerged as an important development challenge of our time with millions of individuals crossing borders in search of better economic prospects political liberties social stability this research project examines how african european immigrants can contribute positively to their home countries stability and institutional quality the study highlights a transition from brain drain to institutional gain where the potential benefits a country can derive from the skills knowledge acquired by individuals who have migrated and gained experience expertise abroad outweigh the loss of talent skills shortages due to emigration this research aims to rigorously explore and critically evaluate the potential impact african immigrants in europe may have on the economic political institutions development of their countries of origin it aims to delve into the intricate dynamics that shape this relationship focusing on the diasporas engagements quantitative qualitative contributions we seek to provide a comprehensive analysis of the myriad ways these migrants might be contributing to or detracting from the development of their home countries considering factors including but not limited to remittances knowledge transfer investment and influence on governance institutional quality we will conduct our research using quantitative qualitative data collection techniques and diverse methods of empirical analysis one subproject involves a crosscountry study covering several african and european nations additionally we will conduct case studies and comparative analyses focusing on diaspora communities from selected african countries that have demonstrated noticeable influences on their home countries political economic landscapes we use mixed methods to examine these nations unique circumstances the study outcomes will be used to offer suggestions for both european and african policymakers
pregnancy and infant preparedness platform in europe

recent epidemics have highlighted how infectious disease outbreaks can severely and sometimes uniquely affect the short and longer term health of pregnant women and their infants nevertheless these groups are invariably excluded from pandemic preparedness and response research as during the covid19 pandemic our ambition is to develop a dedicated pregnancyinfant preparedness platform for adaptive trials to improve pandemic preparedness for these underserved populationsthe objectives of pipeline are to 1 establish a multicountry adaptive trials platform that that can support novel diagnostics vaccines and therapeutics for infections in pregnancy and infancy able to pivot rapidly to emerging health threats 2 create and sustain a responsive and everwarm clinical trial network of sites with expertise in recruiting pregnant women and infants and adaptive trial designs 3 undertake an adaptive platform trial on respiratory syncytial virus immunisation in pregnant women and infants to test the platforms capabilities and address a public health priority for the eu 4 evaluate novel sampling techniques and immunity approaches with relevance for preparedness and 5 embed all activities within sustained dissemination exploitation and communication with key stakeholders to translate results into policy recommendationswe will achieve these objectives through our multidisciplinary partnership with track records in maternal and infant health research who will leverage and strengthen existing networks to maximise europewide outreach to benefit pipeline our objectives are aligned with horizon europe work programme 202324 health destination 3 tackling diseases and reducing disease burden as our work will reduce the health burden of disease through more effective management lead to improved preparedness of health systems to respond to health emergencies and reduce citizens risk of and increase their knowledge about health threats of epidemics
whatif advanced simulations for testing the effect of the information environment on the functioning of democracy

background the rapidly evolving political information environment poses significant challenges to democratic citizenship through eg the spread of disinformation rise of hate speech and lack of crosscutting information methodological challenges including proprietary data limited external validity of experiments and the inability to use societies as experimental playgrounds hinder our ability to comprehensively understand the impact of interventions and regulations in improving the quality of democratic discourse aim whatif aims to develop and critically assess an empirically grounded simulation functioning as a digital twin of the digital political information environment this whatif machine can be used to test the effects of potential policy and regulatory interventions on democratic citizenship offering a tool for evidencebased policy making in the realm of social media quality and regulationapproach our innovative approach combines data donation agentbased modeling and large language models to create the simulation it is validated using immersive virtual field experiments and by modeling whatif scenarios based on proposed policy interventions and regulation cocreation with stakeholders including policy makers and citizens ensures close alignment with their needs finally a critical analysis of the whole empirical chain will give insight into the desirability and legal feasibility of datafication and simulation of the political information environmentimpact our insights into the role of the political information environment in shaping democratic citizenship will contribute to effective social media regulation and interventions we will significantly contribute to novel computational social science methods we will integrate advanced ai tools with existing modeling approaches and use respondentcentered data collection and synthetic data methods to harmonize ccs research with gdpr and other regulations
from keyboard warrior to digital army mapping farright networked publics

the question driving the project from keyboard warrior to digital army mapping farright networked publics mafnet focuses on how farright online communities recruit radicalize and mobilize in response to policy regulations on extremism and terrorism by technology companies in this project i will study the effects of tech company policy responses on farright users by utilizing a comparative focus across north america europe and india studying across these contexts will illustrate the differing ways in which farright users adapt and respond to policies aimed to hinder their activity online although tech companies operate globally policy teams develop local approaches for addressing extremist content on their platforms often guided by national and regional legal frameworks this project utilizes an innovative research design in determining the reciprocal relationship between how farright users act on platforms shifting from individual to collective action and the ways in which tech company policies react to farright activity on their platforms thus shaping farright adaptation techniques online i combine a digital ethnographic approach towards studying online behaviour of farright users with qualitative interviews and focus groups of tech company policy employees this project will elucidate the processes of farright online community building contributing to scholarship on digital cultures media governance and regulation and social movements it will provide insight for policymakers practitioners and tech companies on countering radicalization and recruitment into the farright as well as effective approaches to challenging farright propaganda
novel optical display technology based on mems and metasurface structural colors targeting sustainable displays for consuming electronics

the optics project aims to improve the recent reported display technique of mems microelectromechanical systems metasurface structural colors applicants previous work through redesigning the color filers and the mems cantilevers for practical display applications for consuming electronics the proposed technology combines transmissionbased plasmonic structural colors with mems micro cantilevers to realise full range rgb displays while using only two common earthabundant materials aluminum al and silicon oxide sio2 potentially for cost effective products and fast operation performance optical displays play a ubiquitous role in daily life being an essential component of smartphones computers televisions etc however these devices make up roughly half of the 50 million tons of ewaste produced globally every year in estimate 40 million tons are generally ending up in burn pits or landfills in developing countries causing environment and health problems there is an urgent need for alternative display technologies which are easier to recycle and are financially feasible to be incorporated into sustainable consumer electronics structural colors could be an ideal technology for nextgeneration optical displays several reports have been published on controllable tunable structural colors towards optical displays however none of them meet the basic requirements namely control individual pixel by voltage control color of individual pixels and control brightness of individual pixels we will examine a new type of optical display technology based on structural colors and mems to meet the above requirements implemented at the university of southern denmark this project will allow the fellow to enhance both scientific and communication skills through a welldesigned training program courses workshops regular meeting with supervisors a data management plan as well as measures for knowledge exchange and disseminationcommunication
vascular interactions and remodeling during gestation and its impact on neuronal functions

an intricate network of blood vessels perfuses the brain to support neural cells and carry signaling molecules from the periphery it is mainly considered a rigid transportation network rather than a dynamic and plastic information network integrated to neurons and glia this proposal revisits this concept and aims to define the nature of vascular remodeling in healthy brains i and which remodeling mechanisms play a role in shaping plastic neuronal functions iithe project virgins explores this in the context of the neurophysiological adaptations occurring during and after pregnancy there sexual hormones promote neuronal plasticity which tunes the cerebral control of energy balance and drives the emergence of parental behaviors using our unbiased wholebrain vascular mapping technique tubemap we found that in pregnant mouse brains vascular territories of regions controlling energy homeostasis and hormonal states are remodeled the arcuate periventricular paraventricular and dorsomedial nuclei of the hypothalamus we also found remodeling of blood vessels in brain regions processing pup calls the auditory and prefrontal cortex the hippocampus and subcortical relays the regional specificity of this vascular plasticity suggests precise and complex regulatory mechanisms and a role in shaping neuronal functions in the pregnant stateto link structural functional and molecular changes in the neurovascular unit during gestation we will use light sheet brain mapping neurovascular fast ultrasounds and 2photon imaging with transcriptomics molecular and behavioral tools to determine 1 the nature of whole brain vascular plasticity during pregnancy 2 its mechanisms and impact on the control of energy homeostasis and 3 its role in the tuning of the auditory system to infant calls this project will transform our view on the capacity of the neurovascular unit to sculpt neuronal computation and behaviors