Dragon09/odtu_chatbot huggingface dataset:
malaria diagnosis and prognosis with an electrokineticdriven aptamerbased lateral flow assay

malaria remains a public health concern with 247 million cases and 619000 deaths reported globally in 2021 despite the increasing prevention and control measures driven by the world health organization who nearly half of the population is still at risk of malaria with a reported increase in the incidence of imported malaria in european countries to this end implementing largescale highcoverage early diagnosis and accurate prognosis of severe malaria is critical to reducing the impact of malaria in europe due to its high sensitivity parasite counting by microscopy observation is the current gold standard method however it is inappropriate for its application at the point of care poc the rapid diagnostic tests rdts based on lateral flow assay are the best option for poc testing since they accomplish the reassured criteria who recommends however this method doesnt provide quantitative prognostic information and has proved low clinical sensitivity with low parasitemia samples asymptomatic parasite carriers with this aim i propose for the first time the development of a smartphonepowered electrophoreticdriven aptamer paperbased lfa capable of providing a quantitative measurement of 2 parasite pfhrp2 panpldh and 2 host ang2 and crp malaria biomarkers within minutes compared to capillaritydriven lfa the flow control by electrophoresis enables the application of different synergic strategies to increase assay sensitivity such as integrated incubation steps and purification of interfering biomolecules highly specific aptamers will be developed by a fast and costeffective microfluidic selection approach used as bioreceptors with stability for electrokinetics this will enable an early diagnosis and an accurate prognosis of malaria reducing the risk of developing severe symptoms upon successfully validating the device in nonendemic areas host institution i expect its use in lowresource malariaendemic areas
next generation circular biobased flagship packaging a catalyst for the green transition

the terrific project will demonstrate at trl 8 biobased circular flagship solutions for improved properties packaging applications fulfilling the superior requirements in terms of performance along their entire supply value chain while improving circularity and resource efficiency to do so 6 ambitious specific objectives have been selected implement a firstofits kind multipurpose biorefinery for the obtaining of biobased building blocks including 14biobdo and c18dca at trl 8 and demonstrate its replicability successfully produce of biopolyesters and biomaterials with rrm 95 and improved properties barrier and durability at trl 8 including 14biobdo c18dca from the multipurpose biorefinery develop biobased recyclable compostable and highperforming flagship packaging products by means of traditional industrial technologies demonstrate the sustainability circularity and safety of the biobased materials developed for the flagship packaging products with respect to existing fossil or biobased benchmarks improve circularity and resource efficiency through the validation of multiple endoflife scenarios for the developed flagship products evaluate and demonstrate the replicability of the terrific concept through a multiactor approach to create an interactive innovation model for engagement of all the actors in the value chain in the exploitation of new business opportunitiesterrific is a multidisciplinary project engaging 19 partners from 9 countries covering the whole value chain including 6 smesan implementation plan is presented in the form of 7 work packages 5 of which are technical in nature synergy in communication and dissemination by the several partners and stakeholders including a multiactor interest group will maximize the project progress and impact solutions to overcome the barriers as well as appropriate deliverables tasks milestones and risks to complete the project objectives in due time are presented
ignite the immersive media sector by enabling new narrative visions

the future of media experiences is still to be written and the maturity of extended reality xr and artificial intelligence ai technologies provides a unique window of opportunity for the european creative and cultural sector ccs to reimagine digital cocreation interaction and engagement possibilities transmixr a consortium of eight representatives from the ccs and twelve leading industrial and academic partners combines the necessary interdisciplinary skillsets and domain expertise to create a range of humancentric tools for remote content production and consumption via social virtual reality the projects transmixr platform will provide i a distributed xr creation environment that supports remote collaboration practices and ii xr media experience environment for the delivery and consumption of highly evocative and highlysocial immersive media experiences the groundbreaking ai techniques for the understanding and processing of complex media content will enable the reuse of heterogeneous assets across immersive content delivery platformsusing the living labs methodology transmixr will develop and evaluate four pilots that bring the vision of future media experiences to life in four ccs domains i news media broadcasting ii performing arts and iii cultural heritage additionally the project will harness the creativity of the ccs and will forge interdisciplinary collaborations to demonstrate how immersive social experiences could be transferred to new application areas beyond the ccs the results of the project will contribute to the media and audiovisual action plan from the european commission in particular boosting the adoption of xr technologies opening new business models opportunities in new application areas and markets and gaining worldwide leadership in xr technologies while being deeply grounded in european values such as veracity diversity connectedness and universality
beyond bad apples towards a behavioral and evidencebased approach to promote research ethics and research integrity in europe

ethics and integrity are key dimensions of excellence in research and crucial for public trust in science beyond will reinforce efforts to promote adherence to the highest standards of research ethics and integrity reri and prevent research misconduct rm by developing and disseminating regulatory and educational interventions that elucidate institutional and individual responsibilities for ensuring and fostering research environments conducive to ethical research to that end beyond will adopt a complex ecosystemic perspective on research ethics and integrity that recognizes the multiple responsibilities of researchers and other stakeholders to enrich the overly simplistic bad apples approach that underpins most existing measures to prevent research misconduct beyond will explore the existing literature on behavioural ethics and moral psychology as well as the socioeconomic consequences of research misconduct and engage all involved stakeholders in a public consultation to guide and equip all stakeholders in the research ecosystem beyond will utilize this knowledge to develop 1 psychologically informed contextual interventions to promote reri and prevent rm from the perspective of individual and institutional responsibilities 2 methodologies to measure the short medium and longterm impact of reri trainings on attitudes and behaviours of students and researchers 3 a best practice manual and guidelines to supplement standard operating procedures from a complex research ecosystemic perspective as well as a 2030 roadmap towards improving the reri culture and 4 new training materials and tools to supplement existing educational efforts beyond will mobilize all stakeholders via the three thematic networks involved in the consortium enrio eurec the guild and the stakeholder advisory board to ensure widespread dissemination of results and facilitate their institutional uptake and embedding
spatially and environmentally actuable nancomposite hydrogels towards nervous system repair

this proposal aims to capitalize on my unique multidisciplinary expertise in nanotechnology tissue engineering polymerinorganic hybrids and microsurgical techniques while acquiring new proficiencies in the creation of breakable hybrid organosilica nanocapsules mesoporous silica nanoparticles and nanocomposite hydrogels i am driven to tackle the unmet needs opportunities and challenges in the fields of nanocomposite hydrogel design and nervous system repair by combing my current expertise with these new proficiencies to innovate nanocomposite hydrogels that are environmentally and spatially actuable specifically the goal of my proposal is to pioneer spatially distinct and environmentally responsive actuation of nanocomposite hydrogels in response to matrix metalloproteinase9 mmp9 peptide cleavage focusing on applications in peripheral nerve repair in order to achieve this ambitious objective i will develop mmp9 degradable polyethylene glycol pegmesoporous silica nanoparticle composites and mmp9 breakable organosilica nanocapsules through the incorporation of mmp9 cleavable peptides into silica nanoparticle structures mmp9 can therefore be used to induce 1 hydrogel degradation 2 release of encapsulated therapeutics and 3 capture of molecules by cleaved nanoparticle scavengers this proposal details a highly interdisciplinary approach to create a plugandplay nanocomposite hydrogel system to overcome obstacles needed to improve regeneration outcomes by combining neuroscience and microsurgical nerve repair with chemistry drug delivery biomaterials science and tissue engineering finally nanocomposite nerve guidance conduits will be tested in a peripheral nerve injury model to demonstrate in vivo mmp9 actuation of these hydrogels
fostering nitrogen deposition assessment over portugal

the portuguese ecthe portuguese ecosystems belong to the most nitrogen n sensitive in the world and are being threatened by n deposition current assessments indicate that the scenarios compliant to the national emissions ceiling nec directive show that this situation is not about to change even with the significant emission reductions planned until 2030 in europe hence the portuguese ecosystems remain at risk but current research and policy support capacity are lacking fonda twinning proposal aims to further develop the expertise of university of aveiro uavr portugal in the field of modelling mapping the emissions transport transformation and deposition of reactive nitrogen nr compounds through a strategic research partnership with tno the netherlands and the free university of berlin fub germany moving towards a highly productive scientific research group understanding the budget of n species is of great importance to better understand the interactionsfeedbacks between atmospheric chemistry biodiversity and climate change the two internationally leading groups are complementary in their orientation towards fundamental science and education fub and applied science and policy support tno together they are responsible for the n deposition mapping for germany and the innovation therein the key role of uavr will be to coordinate this consortium of excellence in the air quality modelling field while developing and increasing its knowledge expertise and reputation on n science besides the strength of uavr excellence in the field of air quality by building a national capacity and infrastructure to independently quantify nationwide n deposition fonda aims to train a new generation of highly skilled researchers by offering innovative education and advanced training programs for researchers in their early career stages develop an innovation framework that is sustainable and allows for strategic collaboration after the project
equitable resilience solutions to strengthen the link between cultural landscapes and communities

our common heritage is a central element of our communities and economies and a principal but vulnerable dimension of our common identity as europeans it has been proven that cultural heritage contributes to wellbeing social cohesion identity local economy territorial attractiveness and environmental sustainability but the climate crisis and natural hazards endanger this heritage we propose rescueme to take immediate action for demonstrating how an innovative datadriven communitybased heritagecentric actionable landscape approach to resilience enhancement can protect our cultural heritage and landscapes while supporting the transition toward a green society and economy that sustains resilient cohesive natureconnected communities rescueme proposes a call for action broadening the scope triggering action untapping and mobilizing resources engaging actors and facilitating the decision making and the implantation of cocreated just resilience solutions to protect our common heritage rescueme will develop test and demonstrate the effectiveness of an actionable framework based on the resilient historical landscape approach rhl complemented by data models methods and tools able to assess risks and opportunities codevelop inclusive and just resilience strategies and innovative solutions to protect european cultural heritage and cultural landscapes from climate change disaster risk as well as other stressors such as pollution and overtourism with special focus on european coastal landscapes since a large share of this endangered heritage there the five case studies psiloritis in creta neuwerk in hamburg portovenere cinque terre the islands valncia and the city of zadar have been selected carefully as complementary representatives of european coastal landscapes they will act as resilience landscape laboratories r labscapes validate the results and ensure their replicability
opioids and insulin secretion a new avenue to fight type 2 diabetes

type 2 diabetes t2d and obesity are leading causes of morbidity and mortality becoming a major burden on public health failure to understand their pathophysiology has frustrated efforts to develop improved therapeutic strategies t2d and obesity are complex polygenic disorders genomewide association studies have identified hundreds of loci associated with metabolic traits but they have not led to promising new drug targets so far in contrast the identification and characterization of rare mutations causing monogenic metabolic disorders have been instrumental in repositioning or developing drugs beyond this proof of concept the challenge is to use genomic medicine for innovative molecules restoring impaired insulin secretion that characterizes t2doo has stemmed from the old but forgotten correlation between opioids consumption and metabolic trait abnormalities opioids classically act through delta opioid receptor dop encoded by oprd1 kappa and mu opioid receptors based on my preliminary data that include largescale human functional genetics of oprd1 mutations my hypothesis is that dop is a major link between opioids and metabolism in humans more specifically i propose that dop and opioid signaling have a crucial direct role in insulin secretion from pancreatic cells making dop a promising new drug target against t2din this context i suggest four tasks in oo the first two tasks will decipher the role of dop and opioid signaling in metabolism with a specific focus on islets and cells while the two following tasks will decipher the systemic contribution of opioids and opioid receptors to metabolism the methodologies that i proposed are truly comprehensive and innovative as they combine preclinical animal studies with a humanized mouse model deep phenotyping of islets pharmacology multiomic analyses genome editing functional genetics genetic epidemiology including mendelian randomization and clinical intervention study
federated artificial intelligence for privacypreserving international stratification of colorectal cancer patients

in the eu 1 in 35 women and 1 in 23 men will be diagnosed with colorectal cancer crc in their life span ca 340000 cases and 156000 deaths in 2020 causing an annual economic burden of ca 20 billion eur identifying crc early enables better treatment options screening usually entails a quantitative faecal immunological test fit to predict the need of colonoscopy for the detection of colorectal lesions an expensive and invasive procedure we aim to predict this need with specificity increased by 20 percentage points by using metagenomic microbiomes we hypothesise that computational microbiome profiles extracted using artificial intelligence al technology will allow for optimised personal therapy stratification however clinicians do not have access to broad microbiome data with microbaiome we will develop a novel kind of computational stratification technology to enable microbiomeenhanced precision medicine of crc metagenomic microbiome data to date is distributed over many national registries and privacy regulations are hindering its effective integration with microbaiome we will overcome this barrier by establishing the first privacypreserving federated big data network in crc research we will integrate isolated national databases into one international federated database network rather than a cloud covering metagenomes for over 5000 individuals screened for crc and an expected total of 100000 by 2026 microbaiome ensures that no sensitive patient data will leave the safe harbours of the local databases while still allowing for the classification of clinical crc phenotypes which we will demonstrate in clinical practice allowing regulatory bodies to adopt evidencebased guidelines our consortium combines expertise in crc and its treatment microbiomics artificial intelligence software development and privacy protection to close the gap between privacy and big data in international medical research
cardiovascular risk assessment in menopausal women via multimodal data analysis enabling personalized prevention strategies

womens cardiovascular health is an urgent clinical unmet need as reported by the european society of cardiology esc as cardiovascular disease cvd risk in women still tends to be underestimated by clinicians and women themselves cvd is underdiagnosed undertreated and poorly understood more so in women in the 4060 age group when personalised risk assessment and prevention can have a positive impact on their healthin this context caramel will deliver an innovative personalised prevention model aimed at women 4060yrs based upon a risk assessment stratification model considering sex and gender specific risk factors and a selfassessment and selfmanagement approach using innovative digital technologies empowering women to optimise their cardiovascular health the proposed cvdrisk assessment and stratification scheme will only be possible by the cumulative risk factors analysis fueled by ai emerging from a wide number of different data sources including clinical data from ehr medical imaging biomarkers metabolomics lifestyle information sleep physical activity diet from large cohorts and biobanksa consortium composed by 25 partners and affiliated entities coming from 11 countries composed by 9 clinical entities 6 research organisations and 10 industry and smes will develop test and validate the personalised prevention program in observational and interventional studies in clinical sites in colombia croatia greece lithuania and spain to that end engagement of women aged 4060 will take place from the onset on the codesign and cocreation of the studies and the selfmanagement app ecosystem to be developed likewise gender in research will be mainstreamed all along the interventioncaramel will also deliver policy recommendation and clinical guidelines supporting the design and update of cvd plans by health authorities and healthcare providers considering novel ai based risk models applicable to women aged 4060 yrs
impact of fermentation on the technofunctional and digestibility properties of oatbased cheese

the production of highquality plant protein as sustainable alternative for animal proteins is an immediate requirement for the eu population ferotchee is a multidisciplinary project that focuses on the development of fermented plantbased mozzarellastyle cheese using oat protein the challenges associated with the nutritional and technofunctional properties of oat protein will be addressed using innovative solutions a blending oat protein will be partially replaced with pea protein as a complementary source this approach has a potential to create protein hybrids with a balanced amino acid profile b chemical modification enzymatic hydrolysis may improve the technofunctional properties of oat protein it can also lead to the generation of lower molecular weight peptides with healthpromoting effects and c microbial fermentation this will be the main strategy employed in ferotchee to enhance the nutritional quality of oat protein during submerged fermentation microbial strains will be cultivated individually or in a cocultivation setup using an oatenriched protein substrate microbial enzymes eg proteolytic cellwall degrading and antinutritional factor anfdegrading enzymes generated during fermentation will target issues like poor digestibility low recovery and high anf content in oat protein the oat cheese will undergo assessment for technofunctional properties in vitro digestibility biological activities and the level anf the optimised process which results in the production of highquality fermented cheese at the lab scale will be transferred to a foodgrade pilot plant the majority of this project will be carried out at ucd main host the fellow will also engage in two secondments 1 scientific secondment at inraerennes for study of in vitro digestibility using infogest and 2 industry placement at tirln to upscale the process the fellow will also undergo a training plan that encompasses scientific and transferrable skills
breakthrough brain stimulation device for epilepsy

easee stands for epicranial application of stimulation electrodes in epilepsy it is the first minimally invasive device for focal cortical stimulation based on the laplace electrode central electrode surrounded by a ring electrode easee features 4 distinct electrodes replacing the outer ring connected to 4 independent current sources to account for impedance and anatomical variances in the human skull still the characteristic quadrupolar local electric field with high penetration depth is maintained the stimulation pattern is one of a kind easee is equipped for high frequency dclike and lowfrequency stimulation depending on the condition to be treated in epilepsy intermittent highfrequency stimulation bursts throughout the day are combined with a 20min dclike stimulation session this first is meant to terminate upcoming seizures the second to initiate neuromodulatory processes to downregulate the overexcitability of the epileptic brain area