Dragon09/odtu_chatbot huggingface dataset:
modular manufacturing and distributed control via interoperable digital twins

modapto envisions flexible industrial systems composed of modules enhanced by distributed intelligence via interoperable digital twins dts based on industrial standards moreover it materializes enables collective intelligence within modular production schemes for effective module and production line design reconfiguration and decision support motivated by the six principles of reconfigurable manufacturing systems modapto aims at materializing reconfigurability through the joint use of all principles and not by considering it as an isolated vision of each one to that end modapto focuses on two technological pillars 1 distributed intelligence control via interoperable digital twins2 modular production framework toolkit within modapto each production module is augmented by a dt offering additional distributed intelligence functionalities modapto standardizes the modules interface via aas to enable coordination with other modules and systems modapto also proposes a framework for production design and reconfiguration supported by collective intelligence tools modapto will be implemented in 3 industrial ucs involving 4 manufacturers at 3 different levels to showcase its versatility and applicability uc1 targets the development of production modules robots with novel sustainability capabilities while uc2 production reconfiguration and optimization even for single lots uc3 targets the timely set up of press shop lines and coordination with robots and agvs to handle supply chain disruptions in collaboration with the producer of semifinished product kitsmodapto aims at substantial kpi improvements related to efficiency cost quality energy and sustainability moreover modapto will develop business models facilitating its transferability to other sectors and the adoption of its industrial strategies especially by smes while supporting knowledge transfer via workforce and trainers training activities
natural intraocular photoactivation of compounds to fight retinopathies

retinopathies constitute an extreme societal and socioeconomic burden that is expected to increase with an aging population and the increased prevalence of diabetes these diseases including agerelated macular degeneration and proliferative diabetic retinopathy share neovascularization as a common etiology involving the pathological growth of retinal capillaries leading to blindness if left untreated current treatment modalities involve specialized injections into the eye that require not only outpatient visits to specialized treatment centers but are also associated with significant adverse effects orally bioavailable medications could revolutionize the treatment of retinopathies by reducing adverse effects sustaining vision lowering the direct and indirect financial burden associated with these diseases and increasing access to healthcare inspired by this idea we have developed an approach that can be exploited to target essentially any therapeutic molecule to the eye our novel strategy of drug targeting will not only enrich the modified molecules in retinal tissue but will also reduce the therapeutic oral dose compared to existing antiangiogenic therapy in cancer thereby increasing the safety of the treatment this is achieved by absorbing a minute amount of the chemically and biologically stable molecules resulting in an extremely low plasma concentration and relying on a biological mechanism in the eye to activate the molecules to tether them to retinal target receptors and thereby extracting them from the blood in the present application we propose to demonstrate proofofconcept of this strategy by modifying inhibitors of the vascular endothelial growth factor receptor vegfr vegfr is an endothelial receptor tyrosine kinase that is a key mediator of angiogenesis and an established drug target for the treatment of retinopathies our approach will elicit a paradigm shift in how we design future drug delivery strategies to the retina
high voltage modular and low weight electric powertrains for next generation waterborne transport

electrification of maritime and iw vessels shows a low progress since there are several challenges that need to be overcome before battery energy storage systems bess can compete with other solutions towards the decarbonization of vessels the main challenges are related to the i weight of the bess since a high storage capacity represents a significant share of the vessels cargo capacity in smallmedium sized vessels ii the reliability so that to ensure the troublefree routing and reduction of operating and maintenance costs and iii the safety that is the key to enable the largescale adoption and remove any concern of vessel owners these three aspects constitute the innovation pillars of harpooners and drive the development of a unique modular concept for interfacing with hv onboard grids characterized by a high compactness due to the integration of key components in a single configuration thus eliminating the transformer and a cooling system this ac battery system will be developed together with the management systems for a reliable operation in future powertrains of allelectric or hybrid vessels with reduced emissions the outcome is a reduced weight reliable and safer bess that will allow the uptake of the harpooners solution in both maritime and iw vessels to further increase the battery capacity and achieve a longer autonomy this is extremely beneficial in smallmedium vessels in which full electrification will be possible thus eliminating the use of the combustion engine and its associated co2 and other emissions but also on large vessels in which the harpooners solution with less use of raw materials will lead to a reduced environmental impact and lower manufacturing and maintenance costs to achieve this harpooners has gathered a balanced europeanwide partnership with organizations from the key value chains such as research battery system and power electronics manufacturers shipping owners and a classification society
robot training independence

ronin aims to develop a training toolkit embedded in a robotassisted training setup for supporting adolescents with developmental disabilities dds in achieving independent adult life dds hinder access to formal education for about 4 million children in europe which in consequence compromises their independence later in life this poses a huge challenge for the affected individuals their families and for society one of the major issues that impedes achieving independence by individuals with disabilities is insufficient support focused on training social and cognitive skills crucial for leading independent adult life ronin proposes a solution which uses the embodied learning approach via roleplays with the robot and targets skills necessary for attaining independent adult life independence in i selfcare ii interaction with others and iii facing stressful situations such as exams or job interviews ronins training toolkit includes the training protocol scripts and objects used in interaction encoded robot behaviours and graphical user interface gui for the therapists involving a robot in the training has the advantage that users can benefit from a robot mediator which offers a nonintimidating more predictable and reduced in complexity interaction with less social pressure compared to interaction with another human for the therapists the robot removes the burden of repetitive and lengthy roleplays allowing the therapists to focus on monitoring progress of the training the work plan of ronin consists in designing the training protocol scripts and objects encoding the robot behaviours developing the gui integrating all components in the setup and testing the efficacy of the training protocols with clinical populations should the training prove efficacious it will revolutionise the way support is offered to adolescents with dd their families and therapists and will open a pathway to exploitation
a theory and model of the neural transformations mediating human object perception

in the blink of an eye our brain rapin the blink of an eye our brain rapidly transforms the photons hitting our retina into a rich and detailed percept of the world as consisting of objects by knowing what the objects are and in what configuration these objects appear to us we understand the meaning of the visual world around us yet despite intense research how neural transformations enable rich object perception remains unclear the overall goal of the research program transform is to provide an explanatory theory of the neural transformations mediating rich object perception and a predictive quantitative model embodying this theorytowards this goal transform will provide three strong and novel constraints for theory and model building first transform will reveal the neural transformations underlying visual object perception in the mature brain providing the neural constraint second it will unravel the link between the neural transformation and objectrelated behaviour providing the behavioural constraint third it will clarify the developmental trajectory of neural transformations underlying visual object perception from infancy into adulthood providing the developmental constraint for maximal efficiency and power in unified theory formation and model building transform will employ an integrated interdisciplinary research strategy that combines i largescale noninvasive brain imaging to capture neural transformations in space and time with unprecedented depth ii advanced mathematical analysis to reveal the geometry of the transformations and iii computational modelling using deep neural networks to build a predictive quantitative model of those transformationsthrough this orchestrated effort transform will provide the empirical pieces of evidence for a new theory and model of the neural transformations mediating our rich everyday experience of object vision and change the way we think about and investigate human vision and cognition
advanced sensing monitoring and selfhealing mechanisms to selfrepair batteries

europe must reemerge as a global leader in battery technology by accelerating the development of underlying essential technologies and allowing a european battery cell manufacturing industry as required in the eu green deal rechargeable batteries with high roundtrip efficiency are a vital technology that permits energy storage for numerous applications the lithiumion chemistries now dominate the market for rechargeable batteries however these are near the end of their improvement limits in this direction the advantage of the high energy density of lis batteries is especially significant for novel applications eg where weight is a crucial parameter the project aims to develop and implement selfhealing concepts and materials in the critical battery components used in conventional lis batteries and extrapolate the ideas to develop a new class of selfhealing structural batteries based on lis by investigating at the cell component level it will be built a toolbox of selfhealing materials sensors and a customized battery management system to maximize the performance of the produced lis battery in terms of quality reliability and lifetime and to avoid or repair occurring damages
fuselage rear fuselage and empennage with cabin and cargo architecture solution validation and technologies for h2 integration

the fasterh2 project will validate down select mature and demonstrate key technologies and provide the architectural integration of an ultraefficient and hydrogen enabled integrated airframe for targeted ultraefficient shortmedium range aircraft smr ie 150250 pax and 10002000nm range to enable climateneutral flight aircraft for short and mediumrange distances have to rely on ultraefficient thermal energybased propulsion technologies using sustainable dropin and nondropin fuels besides propulsion the integration aspects of the fuel tanks and distribution system as well as sustainable materials for the fuselage empennage are essential to meet an overarching climateneutrality of the aviation sector green propulsion and fuel technologies will have a major impact on the full fuselage including the rear fuselage the empennage structure as well as cabin and cargo architecture in so far as the integration of storage and the integration of systems for the chosen energy source are concerned h2 direct burn fuel cell not only do the specific properties of hydrogen necessitate a reconsideration of typical aircraft configurations requiring new design principles formulation and fundamental validation exercises but they also raise a large number of important followon questions relating to hydrogen distribution under realistic operational constraints and safety aspects the project will explore and exploit advanced production technologies for the integrated fuselage empennage to reduce production waste and increase material and energy exploitation with integrated fuselage concept selected maturity trl34 until end of first phase in 2025 an anticipated route to trl6 until end of the clean aviation programme in 2030 will ensure entryintoservice in 2035
hybrid amplifier laser for lidar operations

lidar is a highperformance system for monitoring greenhouse gas emissions from space at a global scale however this type of instrument generally includes a complex laser system which has led in the past to significant delays of several european payloads eg admaeolus earthcare or merlin halloa targets the development of a hybrid laser architecture less complex than current freespace lasers for greenhouse gas monitoring by lidar this laser architecture combines the advantages of fiberbased systems compact and alignmentfree with those of freespace direct generation systems high power this development aims to reach the genuine optical performance for lidar co2h2o monitoring from space and for independency purpose to use euonly componentssubsystems halloa will1 develop new eu industrial capabilities and reach eu independency for two key critical subsystems of the hybrid laser the 205 m pulsed fiber amplifier and the highpower laser diode at 793 nm2 space qualify to trl6 the pulsed fiber amplifier at 205m and the highpower laser pump diode at 793 nm3 demonstrate experimentally that a complete hybrid laser system built with euonly componentssubsystems can meet the spacemission requirements for lidar co2h2o monitoringfinally halloa will provide a technical roadmap to establish a european supply chain for the 2m hybridlaser system for lidar application including a business plan for commercial exploitation of the pulsed fiber amplifier at 2m and a strategy for space mission insertionthe project involves 6 entities including 3 nonprofit research entities onera lmd lzh 2 industry keyplayers keopsys lpi and 1 sme erdyn it will pave the way for building a cuttingedge and competitive european supplychain the trl6 demonstration of a hybrid laser system in the eyesafe region for lidar co2 measurements will represent a major step forward for eu technological independence in this domain
untranslated regions of rnas and protein networks in pathological phase separation underpin

aggregation of rna binding proteins rbps is a pathological hallmark of neurodegenerative pathologies such as amyotrophic lateral sclerosis the mechanism leading to rbp aggregation relies on the ability of these proteins to transition into membraneless compartments such as the stress granules sg whose formation is normally regulated in physiological conditions yet as rbps are intrinsically prone to coalesce in large assemblies their accumulation when unregulated can lead to cell toxicity while the effects of amino acid mutations on rbp aggregation have been extensively investigated a large amount of evidence indicates that nucleotide variants in untranslated regions utrs can strongly impact rbp expression by altering the interactions with specific regulatory proteins utrs provide a platform where multiple rbps bind to orchestrate posttranscriptional regulation i envision that utrs by directing contacting specific protein networks are crucial in aggregate formation and that alteration of their interactomesdue to diseaselinked mutationscould impact the propensity to form sg and other assemblies the main objective of underpin is to reveal interactions in regulatory regions of rbps and to understand their effects on phase separation in physiology and pathology firstly i plan to investigate the effects of diseaselinked mutations on utrs of rnas encoding rbps by largescale predictions of utrrbp interactors secondly interactions between rbp and selected utrs with and without diseaselinked mutations will be revealed in human cells by rnaprotein interaction detection experimental method rapid finally the biological implications of utrmediated recruitment of rbps will be deciphered providing molecular details on how utrs and rbps promote the formation of aggregates successful completion of this project will not only lead to new insights into rbp biology but will also pave the way to understand early events of neurodegeneration
how do trees stand legal viability and efficacy of rights of nature and implications for the european union

this project how do trees stand legal viability and efficacy of rights of nature and implications for the european union hron asks how does the conceptualisation of rights of nature ron inform a more consistent eu policy and legal response to ron despite the growing awareness of ron little research has examined the relationship between its legal viability and efficacy the fact that two european union eu bodies received contrasting advice from recently requested studies on whether and how the eu should respond to ron underscores a need for conceptualising ron hron addresses this gap by investigating three aspects of ron conceptualisation legal practice and policy and legal implications for the eu first i will devise a conceptual framework that charts the legal composition of ron based on which its legal viability can be evaluated then i will conduct seven case studies in three countries ie australia new zealand and the us using interdisciplinary methods combining legal interpretation qualitative research and lawincontext analysis to identify the relationship between the legal viability of ron and its efficacy in legal practice and to what extent contexts play a role finally based on the theoretical and empirical research i will analyse their policy and legal implications for the eu in responding to ron hron is an interdisciplinary project that combines the expertise at the university of southern denmark and the centre for law sustainability and justice on innovative legal approaches to sustainability with my multidisciplinary research experience in law philosophy and social science over the past fifteen years hron will be pioneering in conceptualising ron that is supported by qualitative study with policyrelevant outputs it will be particularly valuable for the eus decision making on ron this research directly contribute to achieving horizon europe european green deal and sustainable development goals
terrestrial resilience and restoration strategies for semi arid and fragile ecosystems through a multiactor approach

terrasafe is a pioneering initiative envisaging to empower local communities in southern europe and northern africa to successfully face the escalating challenges of desertification through the adoption of naturebased social and technological innovations terrasafes vision will be operationalized in 5 pilot areas that share a high vulnerability to desertification but simultaneously represent the 4 main types of desertification vegetation decline soil degradation water scarcity and depopulation and strongly contrast in socioculturalecological circumstances this vision is supported by a transdisciplinary consortium ranging from universities to smes commercially exploiting innovationsterrasafes vision is implemented through a multiactor approach covering all wps in particular by setting up 5 partnerships in the 5 pilot areas in a cocreation process these partnerships will then i define their visions on building desertification resilience and plan their ensuing terrasafe work ii map and analyze past and ongoing desertification identifying hotspots iii evaluate and demonstrate innovations at these hotspots comparing them with current and traditionalorganic practices iv elaborate policy recommendation for the wider uptake of the terrasafecertified innovations both within and beyond the pilot areas taking into account lessons learnt from past and ongoing policies against desertification v share their terrasafes experience with the other areas other desertificationprone communities and the general public the consortium will support the partnerships by providing not only harmonized frameworks for each activity but also advice on adapting these frameworks to their specific needs finally the smes will provide a wide offer of innovations that they will tailor towards the respective desertification hotspots in close collaboration with the partnerships
bismuth redox catalysis for cc coupling reactions

formation of cc bonds through transition metalcatalyzed crosscoupling represents the cornerstone strategy to build chemical complexity in a myriad of contexts spanning from academic laboratories to industrial settings these remarkable reactions generally proceed through three elementary steps oxidative addition transmetallation and reductive elimination which couple two organic fragments together using transitionmetal complexes as redoxactive catalysts very recently bismuth a maingroup element has been found to take part in this type of redox events resulting in the formation of different cheteroatom bonds or in htransfer processes however the use of bismuth redox catalysis to forge the highly coveted and synthetically relevant cc bond remains elusivein this project we aim to harness this novel redox behavior of bismuth complexes to unlock the unprecedented bismuthcatalyzed cc crosscoupling full catalytic cycle between organic electrophiles and organometallic nucleophiles for this we propose the design of a lowvalent bismuthiiii redox platform which would cycle through the three key steps of a classical transition metalmediated coupling this will involve the study and optimization of challenging processes such as an unprecedented cc reductive elimination at a bismuthiii center which will be approached through a combination of careful ligand design experimentaltheoretical mechanistic analysis and combinatorial screeningsbesides the conceptual breakthrough derived from such discovery this idea will be used to implement bismuthcatalyzed crosscoupling reactions as competent cheaper and less toxic alternatives to traditional methods based on transitionmetal catalysis furthermore the unique properties of bismuth as a maingroup redox catalyst could potentially combine advantages of both early and late transition metals resulting in the development of more versatile catalytic systems