Dragon09/odtu_chatbot huggingface dataset:
paludiculture largescale demonstrations

palus demos will establish 3 large scale paludiculture demonstration sites to provide insights in new agricultural business models increased employment and improved biodiversity and water quality in line with the objectives of the eu green deal palus demos will inspire entrepreneurs in agriculture biobased manufacturing industry communities politicians water and nature organisations and many others that paludiculture will provide a new direction to preserve peat pastures carbon stores and reduce ghg emissions the proposed bottomup approach agriculture feeds science is an opportunity that can improve social economic and environmental sustainability offering a futureproof model for agricultural entrepreneurs our demonstrators will act as lighthouses or beacons for local stakeholders and others from right across europe beyond the focus of these demonstrators supported by many of europes leading experts is to develop a range of best practices and land uses in strategic locations in three european countries ideally placed to spearhead the establishment of paludiculture practice and markets across europe in a climate smart farming way beyond state of the art we will establish cocreated sustainable paludiculture practices at each of the three demonstrators this will be fully supported by policy recommendations identifying enablers barriers and policy gaps we will work with stakeholders to develop socioeconomic models using the quadruple helix innovation system including government industry academia and society our work will be supported by the development of long term business plans it will include end users of the produced biomass and will be supported by artificial intelligence ai tools cocreated with stakeholders leading us towards an evidence based policy approach to paludiculture innovation
design rules for novel organic photovoltaics from natural photosystems through computational modelling

through photosynthesis nature has mastered the process of harvesting solar energy and converting it into vital chemical products carefully constructed assemblies of lightabsorbing molecules such as chlorophylls collect light energy from the sun to generate excited species called excitons that can spread out among different molecules these extended excitons travel very efficiently to specific locations where they break into charges driving photosynthesis what secrets enable nature to carry out these tasks so efficiently and how can we draw inspiration from themamong the materials used for artificial solar energy conversion organic solar cells made of carbon and hydrogen follow similar steps to natural photosystems and offer practical advantages chemical tunability flexibility and transparency these lowcost materials can make clean energy more widely accessible and help combat dangerous climate change yet efficient molecular solar energy converters require better design strategies denovo applies stateoftheart computation to understand and optimize the primary electronic steps in molecular photovoltaics drawing insights from evolutions exquisite molecular designin synergy with the host group which offers training on advanced multiscale algorithms i will develop a novel method to simulate the entire process from light absorption to charge separation in complex systems spanning a wide range of time scales i will model energy conversion in both wellstudied and new photosystems and will implement natural system features eg wellcontrolled morphology reduced interfacial volume in simplified photovoltaic architectures these design strategies should enhance morphological stability boost charge separation driven by enhanced quantum delocalization and reduce energy losses the longterm goal is to develop scientific knowledge that can support decisionmaking in technology development and mainstreaming of new renewable energy sources
reagentless organic synthesis

this project proposal reagentless organic synthesis through vibrational strong coupling addresses the pressing need in synthetic chemistry for sustainable and environmentally friendly chemical transformations it aims to harness the power of vibrational strong coupling vsc to enable reagentless clean chemical reactions with maximum atom economy and minimal waste generationvsc involves selectively coupling a molecules vibrational transition to the zeropoint electromagnetic fluctuations of an optical cavity this coupling even in the absence of light creates vibropolaritonic states that can alter the groundstate reactivity landscape vsc being a nascent field has shown promise in modifying some chemical reactions however many fundamental questions remain unansweredthe research plan combines the fabrication and characterization of optical cavities monitoring coupling strength and reaction kinetics using ftir spectroscopy product characterization with gcms and nmr spectroscopy and advanced spectroscopic techniques collaboration with experts in computational quantum physics will bridge the gap between theory and experimentthis projects innovative aspects lie in its potential to achieve selectivity in chemical reactions that are challenging or impossible through conventional methods eliminating the need for expensive catalysts hazardous reagents or harsh conditions by exploring a range of reactions and studying the underlying principles this project contributes to sustainable chemical synthesis aligning with the goals of circular economy strategies and innovative energyefficient practices
promoting a plant genetic resource community for europe

plants are the basis of all food feed and renewable bioenergy production and are essential for the transition from a fossilbased to a biobased economy plant genetic resources pgr play a key role in ensuring this transition as well as food security and climate mitigation more than 2 million plant accessions are preserved ex situ in 410 institutes in europe and associated countries and listed in the eurisco database even more diversity is found in situ in european farmlands and wild habitats where it contributes significantly to agricultural resilience and climate mitigation detailed information on ex situ accessions is at best fragmentary while for in situ accessions it is almost nonexistent a considerable part of these resources could be lost over the coming decade due to limitations in the exsitu infrastructure and management climate change habitat loss and invasivealien species the roadmap 2016 of the european strategy forum on research infrastructures esfri identifies a clear gap in the sector plant facilities unlocking green power ie the lack of a european research infrastructure ri specifically dedicated to pgrs prograce will undertake the first step to fill this this gap by developing the concept of a novel ri dedicated to the conservation and study of pgrs the concept will describe the proposed distributed structure governance economic plan and scientific services of the proposed ri and will be the basis for a full proposal at the next esfri call if implemented this new ri will aim to catalog describe preserve and enhance european plant agrobiodiversity and translate the results into conservation practices and agricultural innovation and will collaborate with global organizations dedicated to plant genetic resources and with other established esfri ris working on complementary fields eg elixir emphasys dissco lifewatch mirri
tidal arts transforming and inspiring aquatic landscapes through art and sciences

tidal arts transforming and inspiring aquatic landscapes through art and sciences will reconcile the dichotomy of human versus nature tackling the current climate environmental and biodiversity crisis to this end art and science will work in alliance with civil society citizens cultural and technological institutions to increase awareness about the challenges faced by the ocean and inland waters and inspire the mobilisation of creative solutions for their protection and restoration tidal arts puts forward an interdisciplinary and interspecies approach that involves scientists as knowledge holders citizens as end users and cocreators of the public space artists and creatives as those who can look at the current challenges from a unique perspective and engage the public through symbolic and performative work our approach challenges the binary thinking that has historically divided nature and culture as well as humans and nonhumans and engages instead with a tidal logic that nurtures currents of influence between disciplines and species taking water as both a subject and a praxis tidal arts engages with the cyclical movement of water as a codesign methodology with several rounds of contact with local citizens scientists and cultures in each phase progressively widening the waves of influence of the project
immune mechanisms of experience induced brain plasticity the contribution of brain resident t cells

t cells are part of the adaptive immune response breaking the dogma of the brain immune privilege i demonstrated the presence of t cells in the healthy brain in the mouse brain they regulate neuronal morphology and behavior surprisingly brain t cells respond and proliferate upon exposure to an enriched environment ee suggesting a connection between neural activity and brain t cells ee involves motoric sensory and social stimulation exposure of rodents to ee increases neurogenesis enhances learning and memory with proven beneficial effect in neuropathology how brain t cells can respond to ee and eventually modify the brain is unknown i hypothesize that upon ee t cells adapt their molecular profile and acquire an immunomodulatory phenotype to support the changes occurring in the brain my overarching goal is to understand how ee modulates immunebrain interactions and to harness emerging discoveries to develop novel therapeutic interventions for neurodevelopmental disorders that mimic the beneficial effects of ee currently research into brain functions of t cells is limited by absence of research tools to deplete t cells in the brain only the proposed project will overcome these limitations by developing a novel gene therapy approach for depleting brain t cells first i will investigate how ee influences brain immunity then i will take the opposite approach investigating whether and how brain immune cells act as a necessary mediator of eeinduced brain plasticity making use of the new nanobodybased tool to deplete brain t cells these complementary approaches will allow me to mechanistically decipher how experience influences interactions between the brain and the immune system finally using the fragile x mouse model of autism i will translate the knowledge gained from brain resident t cells into impactful proofofconcepts for treating neurological diseases and mimicking the benefits of environmental enrichment through immunotherapy
nitrogen genetics and physiology for ulva compressa sustainability

nitrogenious is an interdisciplinary project that will provide unprecedented knowledge on the genetics and metabolism of the green seaweed ulva compressa for a sustainable and thriving aquaculture seaweed is the most rapidly expanding aquaculture sector with a potential to reduce the environmental impacts of terrestrial agriculture to contribute to climate change mitigation and provide ecosystem services the main application for the cosmopolitan ulva compressa with a high growth rate under various environmental conditions are food feed bioremediation however its domestication and breeding are still in their infancy and companies are largely relying on wild harvest nitrogenious aims to elucidate genes and biochemical processes involved in nitrogen uptake and assimilation and to understand how they are impacted by increasing temperature to improve yield and bioremediation capacity and to decrease the environmental impact of its farming more specifically it will a clone and characterize genes for nitrogen uptake assimilation and regulation to open the way to modern breeding b advance the knowledge of u compressa nitrogen metabolism under optimal conditions and determine how it is affected by increased temperatures and c test at pilot scale the most promising strains obtained in the lab for bioremediation potential and biomass yield advanced methodologies will be employed in collaboration with the host lab scientific partners chemicallyinduced mutagenesis highthroughput phenotyping whole genome sequencing genome editing in a secondment and metabolic fluxes via liquid chromatography coupled with mass spectrometrybased on the results of the project advantageous alleles could be selected from natural populations and the physiological understanding gained will help optimizing n nutrition and cultivation techniques to increase the production without increasing external input of fertilizers
midinfrared wearable for noninvasive biomarker monitoring

modern medicine has improved dramatically through a better understanding of what causes a condition or what it is correlated to however the healthcare system still follows an episodic reactive model where patients only seek medical advice when there are symptoms which for certain medical conditions has proven critically insufficient in this context one of the main burdens for our socioeconomic system in europe by a single disease is without question the metabolic syndrome mbs mbs is prominently visible in the large and evergrowing number of overweight or obese individuals yet its true negative dramatic consequences among others are arteriosclerosis hereby induced myocardial infarction and stroke several biomarkers such as uric acid albumin or ketone bodies correlate with mbs and often indicate different aspects of the metabolic syndrome the more biomarkers can be measured and quantified with high accuracy the easier it becomes to make conclusive decisions on the patients status false negatives as well as false positives can be avoided much better with more parameters if each of them is measured individually and directly without the need for indirect methods where evaluations are easily overfittedwe provide an alternative approach for the measurement of biomarkers using a miniatured midinfrared spectrometer a technology that is only used in laboratories due to its size and cost the result of the project will be a wearable device to detect biomarkers noninvasively and painfree in the interstitial fluid in the skinfor miwear we have gathered an impressive consortium combining expert knowledge on biomarkers optical spectroscopy laser physics business management finances and the gender dimension of biomarkers during the project we will generate opportunities for young researchers and engage with different stakeholders to ensure maximum outreach of our research and development activities
tackling functional maturation for transplantable hematopoietic stem cell generation

hematopoietic stem cells hsc provide a lifelong supply of blood and immune cells they are a lifesaving therapy for leukemia and have recently found broadened applications to gene and cell therapy against other cancers genetic autoimmune and infectious diseases nonetheless practical limitations such as donormatching or insufficient cell number render these therapies unfeasible or unsuccessful for many patients attempts to overcome these limitations have been unable to create a reliable source of hsc for patients while we can generate human hsc from pluripotent stem cells psc they resemble early development stages lacking the functional maturation hallmarks funhsc aims at identifying core and actionable maturation pathways for hscs and at defining the contribution of coordinated gene expression by chromatin regulation using a combination of functional and genetic screening technologies and highthroughput readouts in vitro and in vivo hsc maturation occurs in the liver during fetal development and confers functional multilineage hematopoiesis ability throughout adulthood using single cell omics analysis of human embryonic and fetal tissues we describe multiple gene programs changing during developmental hsc maturation this study will lead to candidate cellintrinsic and nichedependent instructions which will be dissected in the context of the fetal liver by analyzing the cell compartments and their interactions and by combining novel organoid technologies with mouse xenografts to model the fetal liver environment ultimately we aim to identify a strategy that mimics these pathways in vitro to bring the maturation stage of the pscderived hsc to a robustly engraftable and clinically valuable hsc source harnessing new knowledge in human hsc biology cuttingedge genetics and tissue technologies funhsc will provide great advances in the mission of making and maintaining hscs in vitro enabling their full therapeutic potential
transformdairynet working together to upscale cowcalfcontact dairy production and beyond

transformdairynet will harness the expertise of 26 european partners to create 11 national innovation practice hubs and a european knowledge and innovation network of dairy farmers veterinarians advisors supply chain actors farmer organisations researchers and policy makers to work together to upscale cow calf contact ccc dairy production and beyond keeping cows and calves together for months rather than the usual hoursdays promotes health growth and normal pleasurable behaviour and is the most consumer accepted ethical practice for increasing the sustainability of dairy systems in line with the green dealtransformdairynet aims to accelerate the adoption of ccc orientatedpractice through 1 compiling existing knowledge and identifying enduser needs 2 cocreating new ccc knowledgegenerating ideas and solutions 3 sharing knowledge ready for practice and 4 ccc legacy and tools for transforming systems through a multiactor approach transformdairynet will bring science and practice together to create a comprehensive ccc knowledge map champion farmerled innovation and share practice to upskill european dairy farmers and advisors at differences stages of adoption transformdairynet will build resilience and normalise and spread ccc practice by cocreating harmonised farmerfacing tools materials and peertopeer activities leveraging trusted channels and networks and engaging with existing and new dairy and ccc focused eipagri operational groups transformdairynet will work with eu farmbook to maintain the knowledge and innovation networks beyond the project as a community of practice able to pivot to other issues for the continued transition to sustainable dairy production into the future looking forward transformdairynet will provide insights and recommendations for the acceleration of other novel agricultural practices with high citizen and practitioner demand through reflecting on the thematic network processes
lineage tracing of the human brain

organisms develop through cell divisions generating clones that progressively organize to form different tissues this process can be visualized as a cell phylogeny by lineage tracing in order to track cell lineages each cell division has to be permanently and uniquely marked in model systems this is done by genome editing in humans this is not applicable which has historically made impossible to accurately study cell phylogenies very recently however studies showed that human tissues contain a set of natural markers in the form of somatic dna variants that permanently and cumulatively label every cell division during development my work showed that somatic variants are reliable at tracking cell lineages directly in human tissues human brain development has historically been difficult to address since humanbrainspecific features are hardly recapitulated in any existing model my project now builds on the use of somatic variants to reveal the cellular processes that form the brain starting from available human material somatic variants will be identified at unprecedent sensitivity in a large set of human foetal tissues including multiple different brain regions in work package wp1 i will identify and study the lineage segregation steps defining the brain phylogeny starting from the zygote mathematical modelling will elucidate mechanisms of clone dynamics in wp2 i will focus on the cerebral cortex and reconstruct cell phylogenies of neural progenitors and the distribution of cortical clones furthermore i will compare normal versus overgrowth cortical malformation brains where cell proliferation and migration are altered in wp3 i will develop new strategies to simultaneously assess cell phylogenies and celltype specification by identifying somatic variants in multiomics data this project will reveal the unfolding of the cellular lineages building the human brain while providing a methodology that is applicable to any tissue and pathology
fabrication of 3d metasurfaces to enable the next generation of high efficiency optical products

fabulous will develop an industrial surface coating technology that exploits breakthroughs in multiphoton lithography and process modelling to manufacture high resolution 3d metasurfaces at a throughput viable for series production these metasurfaces will be capable of manipulating light with unprecedented flexibility and will open the possibility of designing and manufacturing smaller lighter and more environmentally friendly products through the replacement of bulky components andor the chemical coatings currently used to enhance the efficiency and performance of optical products the project will explore novel methods for rapid 10cm2min microfabrication of highresolution smaller than 200nm 3d structures and the development of new production tools to optimise the design and integration of the metasurfaces into functional products these innovations will then be scaled for commercial applications and integrated into an industrial platform with a quality assurance and control system enabling the fabrication of 3d metasurfaces on a range of substrates with unprecedented productivity resolution flexibility and reliability the application of the technology and its potential to contribute to the design and manufacturing of more sustainable and circular european goods will also be demonstrated in a series of uses cases the platform will be used to coat optical components lenses light pipes and microoptics arrays with custom metasurfaces and demonstrate that these components when integrated into the design and manufacturing of functional optical systems cameras automotive lights and pv cells can significantly improve their efficiency whilst in parallel reducing their environmental footprint