Dragon09/odtu_chatbot huggingface dataset:
evtol multifidelity hybrid design and optimization for low noise and high aerodynamic performance

this project supports the digital transformation of aircraft design by developing new multidisciplinary and multifidelity simulation tools that will enable novel aircraft architectures with improved aerodynamics and reduced noise emissions this project addresses more specifically the design issues of electric vertical takeoff and landing aircraft developed for urban air mobility but the innovative designoptimization framework that are proposed in this project are equally applicable to other novel aircraft architectures such as those based on distributed electric propulsion boundary layer ingestion or open rotors one common issue for most novel aircraft concepts is indeed the complexity of the aerodynamic and acoustic interactions between the liftthrust systems and the airframeevtolution is designed as a lowtomidtrl enabler project meant to develop the knowledge data tools and methods that are necessary to understand model and optimize aerodynamic and aeroacoustic installation effects the main objective of the project is to implement and demonstrate a novel design and optimization framework built upon three pillars i exploit the strengths of low mid and highfidelity simulation methods at each phase of the design ii accelerate the optimizations while preserving robustness thanks to datadriven surrogate models combined with physical models and iii further consolidate the accuracy and robustness of the design and optimization using advanced experimentalnumerical crossvalidation and training methodologiesthe realization of these objectives will be achieved through design exercises defined by the consortium under the guidance of its aircraft manufacturers the analysis of the design exercises will permit quantifying the gains achieved in terms of design cycle time prediction accuracy optimization robustness the efficiency of the noisemitigation technologies and eventually the acceleration of the certification process
preact prediction of radiotherapy side effects using explainable ai for patient communication and treatment modification

radiotherapy is a widely used cancer treatment however some patients suffer side effects in breast cancer side effects can include breast atrophy arm lymphedema and heart damage some factors that increase risk for side effects are known but current approaches do not use all available complex imaging and genomics data the time is now ripe to leverage the huge potential of ai towards prediction of side effects this project will use rich datasets from three patient cohorts to design and implement an ai tool that predicts the risk of side effects including arm lymphedema in breast cancer patients and provides an easily understood explanation to support shared decisionmaking between the patient and physician the preact consortium combines the expertise in computing mdw auebrc ai hesso centai radiation oncology maastro unicancer medical physics thera genetics uleic psychology cnr and health economics um that is necessary to tackle this problemthe project will integrate data from the three cohorts and build ai predictive models with builtin explainability for each of the key side effects of breast cancer radiotherapy these ai models will be incorporated into an existing commercial radiotherapy software platform to create a worldleading product the extended platform will be validated in a clinical trial to support treatment decisions regarding the irradiation of lymph nodes the trial will adopt an innovative design in which the patients and medical team in the test arm will receive the risk prediction but those in the control arm will not a communication package built with a codesign methodology will ensure that ai outcomes are tailored to stakeholders effectively the trial will evaluate whether using the ai platform changed the arm lymphedema rate and impacted treatment decisions and qualityoflife generalizability of the ai models for other types of cancer will be sought through transfer learning techniques
polarization sensitive photodetection by straining moir van der waals superlattices

the stacking of two dimensional materials with control of the relative twist angle led to the formation of longrange ordering structural modulation of the atomic lattices with the generation of moir potentials twistronics is a blooming and promising new avenue to achieve optoelectronic devices with extra functionalities offering plenty of opportunities that can be combined with the wellestablished field of straintronics in this project a number of layered materials combinations and straining methodologies will be investigated by in situ atomic force microscopybased methods such as piezoresponse force microscopy kelvin probe force microscopy and tipenhanced raman spectroscopy to visualize the moir domains under strain finally the project endeavors to engineer photodetectors with straintunable polarization using marginally twisted strained van der waals heterostructures
an integrative genetic approach for the exploration of melanoma immunological interactions

immunotherapy which has revolutionized cancer treatment largely relies on the immune systems recognition of neopeptides degradation products of altered proteins specific to cancer cells presented on their surface in particular cancer vaccines targeting neopeptides have shown promising clinical results yet to optimize their efficacy and broaden their application we need to decipher the nature of the cancer peptide landscape immunopeptidome and delineate the neopeptide properties required to induce a potent immune response the overarching goal of this proposal is to provide an unprecedented thorough multifaceted understanding of the mechanisms underlying aberrant peptide production peptidemhc presentation and tcell recognition in melanoma we will do so by pursuing three key avenues systematic interrogation of the cancer immunopeptidome to identify novel canonical and noncanonical cancer antigens and quantify their presentation aim 1 comprehensive functional assessment of the intrinsic qualities of actionable antigens by quantitatively charting the immunopeptidome invivo while considering peptide presentation levels clonality and crosspresentation and delineating how these neoantigen qualities impact the immune response aim 2 establish controlled invivo models to tease apart neoantigen qualities for the establishment of rational cancer vaccine modalities aim 3 in this effort we will draw upon our pioneering tools and advanced mapping of the cancer peptidome in melanoma which has already revealed novel antigenic sources our research approach combines comprehensive quantitative immunopeptidomics novel imaging and computational approaches advanced functional assays and novel mouse models our project will provide a fresh view of melanomaimmune interactions new research tools and pipelines cancerspecific antigen targets for immunotherapy and more broadly a paradigm for addressing similarly complex questions in other cancers
changing practices and habits through open responsible and social innovation towards zer fod waste

chorizo aims to improve the understanding of how social norms rules or expectations that are socially enforced influence behaviour related to flw generation to significantly accelerate progress towards zero food waste chorizo aims to use this knowledge to increase the effectiveness of decisionmaking and engagement of food chain actors in changing social norms towards zero food waste to achieve its aim the project will provide evidence on the role of existing social norms in actors flw behaviours through translating results from previous flw actions into evidence and generate new evidence on social norms flw behaviours second chorizo will embed these research results into innovation products that can foster change of flwrelated social norms these products include more effective sectorbased guidance communication science education packages and capacity building actions chorizo employs reallife case studies css to serve its three interlinked purposes i to provide information and data on the context and impact of previous flw preventionreduction actions undertaken by the case study members thus enriching the evidencebased analysis on previous flw actions ii to generate new evidence on the interaction between social norms behaviour and food waste to feed into the projects fw models and innovation products iii to validate the communication science education packages of the project moreover on the technical side chorizo will utilise advanced modelling techniques to produce solutions that integrate behavioural and economic theories and integrate gender and intersectional analysis to interpret social norm and behavioural data and to effectively engineer innovation processes and outputs
smart crystal nucleation near interface dynamics in active pharmaceutical ingredients

one of the most important challenges that drug development researchers face today is the low aqueous solubility of the active pharmaceutical ingredients apis most of the drug molecules under investigation exhibit poor water solubility and additional efforts are required to improve their solubility feature thus the development of amorphous drugs is the most effective way how to improve the bioavailability of the apis and huge amount of effort is directed towards this smart approach the aim of this project is to develop a reliable and universally applicable dynamic physiochemical procedure for the description of the interconnection between the microscopic and macroscopic description of the triggered phase transformation a task that would lay fundamental principles for the prediction of the macroscopic manifestation of the sub neartg crystal growth in the class iii amorphous drugs this proposal is smart as this is first case of designing the unique green dynamic and advanced molecular crystal nucleation near interface in addition the smart project also aims to develop the combined experimental and mathematical procedural approach for fast reliable and accurate projections of the sub neartg amorphoustocrystalline dynamic transformation in amorphous apis
chirality inversion in colloidal selfassembly

the chiral selfassembly of nanoscale building blocks offers a scalable route to functional materials but understanding and controlling this process is a persistent challenge a notable example is cellulose nanocrystals cncs elongated nanoparticles extracted from natural cellulose that assemble into a cholesteric liquid crystal phase in aqueous suspension this helicoidal selforganisation can be preserved into the solid state to create structurally coloured films offering a sustainable way to produce nextgeneration pigments and colourants however the cnc cholesteric phase is always found to be lefthanded due to the presence of bundles a subpopulation of cncs that act as colloidal chiral dopants and induce lefthanded ordering inspired by the naturallyoccuring cnc bundles this project aims to produce cellulose polycrystals cpcs a new class of clustered nanoparticles produced by the aggregation of cncs in the presence of a chiral glue provided by hemicelluloses these cpcs will then be used as synthetic chiral dopants to induce a righthanded cholesteric phase in cncs suspensions for the first time this inversion of the handedness of cnc selfassembly will result in films that reflect rcp light in the visible range enabling the creation of structurallycoloured materials with nearideal optical performance these findings will deepen our understanding of chiral colloidal selfassembly and open up new avenues of enquiry for research on biosourced nanomaterials
the role of neuropeptides in hostparasite interactions from molecular signaling to behavioral responses

parasites can be found everywhere playing crucial roles in ecological economical and evolutionary contexts despite this hostparasite interactions particularly those involving parasites that manipulate their hosts behavior to enhance transmission are severely understudied we therefore lack the knowledge to fully understand parasite evolution ecology and ecosystem impact to begin uncovering the molecular basis of host manipulation i aim to study the parasitic horsehair worm gordionus violaceus known for its ability to force its arthropod host into drowning itself i will analyze the neuropeptide np complement binding affinities and behavioral consequences of host manipulation to do so i will identify nps and receptors in g violaceus and its host the cricket gryllus bimaculatus via a bioinformatics survey and validate my results via mass spectrometry next i will assess the binding affinity between candidate parasite nps and host receptors by transfecting cells and measuring their luminescence response lastly i will validate the functionality of the candidate nps and receptors in a behavioral assay exploring waterseeking suicidal and predator avoidance behavior in crickets exposed to the candidate nps as well as crickets infected with g violaceus introducing single and multiple injections will allow me to discern doseresponse relationships this proposal integrates cuttingedge techniques in bioinformatics molecular biology and behavioral analysis offering a holistic approach to untangle the intricate np dynamics within a hostparasite system as we start to understand hostparasite interactions and manipulation we can gain crucial insights into the delicate balance of coexistence between organisms shedding light on the ecological dynamics and the remarkable strategies that parasites have evolved to ensure their survival and transmission within complex ecosystems
comprehensive paediatric palliative care approach

palliakid is an interdisciplinary project aiming to evaluate the feasibility effectiveness and costeffectiveness of novel interventions for children adolescents and young people aya with palliative and endoflife care needs in different healthcare systems across europe with a focus on those factors that influences the active patients and family caregivers engagement palliakid responds to several needs or gaps identified by the consortium clinical partners grouped into three cornerstones of paediatric palliative care 1 early identification of children and ayas with palliative and endoflife care needs 2 comprehensive assessment of children and their family caregivers needs 3 a comprehensive personalised interdisciplinary care plan including advance care planning the proposed solution entails three main results palliakid eary detection system palliakid intervention needs assessment advance care planning and patient journey digital platform and palliakid xrbased capacitybuilding program for professionals in addition the project will develop policy recommendations guidelines and standards for patientcentred communication together with a scaleup strategy to guarantee the project results sustainability and impact in this sense palliakid aims to reduce taboos and misunderstandings of paediatric palliative care with its activities and the planned public engagement strategy the consortium is composed of 19 entities with the needed and complementary expertise and knowledge to respond to the proposed objectives including the triad perspective childfamilyprofessional five clinical sites to codesign and test the palliakid solutions two european networks four experts in the needs assessment and acp tools to be adapted hexcom and impact three technological partners one expert in evaluation three experts in ssh and one expert in data and ethical issues
network of national contact points for cluster 2 culture creativity and inclusive society and ssh integration

national contact points ncps are officially appointed to advise researchers and other relevant eligible stakeholders in their efforts to secure eu funding in this context the eufunded net4societyhe project is the transnational network for horizon europes cluster 2 culture creativity and inclusive society cl2 ncps building on past initiatives the project will further develop services created by its predecessors to support todays ncps to that end it will design activities to ensure all cl2 ncps have the relevant knowledge and skills required to offer a consistently high degree of professional highquality tailormade services to potential programme applicantsnet4societyhe n4she is the transnational network for cluster 2 culture creativity and inclusive society cl2 national contact points ncps in horizon europe ncps are officially designated to advise researchers and other relevant eligible stakeholders in their efforts to secure eu funding n4she builds on net4society the network for societal challenge 6 ncps in h2020 and ncps for socioeconomic sciences and humanities in fp7 and will further develop services and tools created by its predecessor to help ncps to succeed in their work through its planned activities n4she will ensure that all cl2 ncps have the relevant knowledge and skills necessary to adequately and competently offer a consistently highdegree of professional highquality tailormade services to potential programme applicants all nominated cl2 ncps including nonbeneficiaries will have access to information and capacitybuilding tools and events organised by the project such as cl2 ncp info sessions trainings and network meetings n4she will support prospective applicants in cl2 with a special focus on new stakeholders eg csos ccis glams galleries libraries archives and museums and researchers from countries with lowerthanaverage results and participation in h2020 the project will facilitate multiactorinterdisciplinaryinternational consortiabuilding through organisation of brokerages bilateral meetings of project initiators and researchers from widening countries via use of a partner search platform tool n4she will also organise info days and proposal check events to encourage participation and development of successful proposals to support ssh integration across horizon europe n4she will organise sshthemed brokerages special trainings on the topic for ncps and publish an ssh opportunities document highlighting ssh research funding chances beyond flagged topics within horizon europe including in missions and partnerships and separately publicise opportunities in other eu programmes in addition to other actions
homological invariants of deformations of groups and algebras

the pervasive role of algebraic topology in mathematics is proof of the powerful effects that homological invariants produce in the development of the discipline extending these techniques beyond the category of topological spaces in order to include quantized systems arising from dynamical systems and quantum groups is going to be extremely useful to make fast progress in these fields the framework of operator algebras and noncommutative geometry is extremely wellsuited for these developments and has already been applied with some success the goal of this proposal is to further develop these homological techniques by supporting them with novel methods based on triangulated categories homotopy theory and index theory the research problems tackled in this action are deeply related to important topics which attracted a great deal of interest in the mathematical community for example we study the celebrated baumconnes conjecture for both groupoids and quantum groups through a relatively unexplored perspective and relate it to the computation of ktheoretic and homological invariants for notable dynamical systems eg smales axiom a diffeomorphisms this research will provide mathematicians with both conceptually new approaches and powerful computational tools some of these results are relevant not only for pure mathematics but also for solidstate physics and quantum information theory this action will take us one step closer to the solution of significant problems or the formulation of more and more refined research questions this fellowship will allow v proietti to work under the supervision of m yamashita a worldclass expert on quantum groups at the university of oslo a leading institution in operator algebras it will expand the fellows technical expertise and integrate it with essential management administrative and dissemination skills which will help v proietti reach a position of professional maturity
olfactormativity exploring the intervening performativity of smell

smells intervene in human experience used by police or military for crowd control they are a perfidious weapon yet they also offer a wealth of material for intervening arts the exploration of which is currently gaining traction against a backdrop of climate change and the rise of sexism and racism so far however research on the intervening potential of smell has remained the province of military sciences with research on intervening arts focusing on the visual and the auditory neglecting the disruptive power of olfaction olfac bridges this gap by for the first time exploring the intervening performativity of smell at the intersection of arts and politics assuming that odour can be used both to stigmatize and at the same time to help unlearn socially trained norms olfac will 1 empirically investigate olfactory actors techniques and technologies applied across performing arts and governmental contexts and 2 develop an integrative transculturally aligned and intersectionally oriented theory of olfactormativity fundamentally the project explores the following questions how do olfactory techniques and technologies applied in performing arts relate to those used by police and military what dangers and potential for change do they pose in what sense are olfactory actors capable of interrupting subverting or displacing movements of assembly to what extent can olfactory art break up historically evolved social structures and change perceptual routines does the subversive use of odours lead to radical ruptures and changes in terms of gender class and ethnicity or does it ultimately lead to strengthening conventional concepts of identity a highly transdisciplinary endeavour olfac draws together approaches and findings from artrelated disciplines cultural studies anthropology psychology neurobiology and chemistry and is set to establish an entirely new playing field for studying the interaction of power arts and the senses
lighthouse for atlantic and arctic basin

the eu has set bold quantified and measurable targets to achieve its ocean mission objectives relating to protecting and restoring marine ecosystems and biodiversity mission objective 1 preventing and eliminating pollution of our ocean mission obj 2 and making the sustainable blue economy carbonneutral and circular mission obj3 by 2030 the eu mission implementation plan has two demanding but necessarily nearterm phases the first development and piloting phase by 2025 and the second deployment and upscaling phase from 20262030 pharos will be the logical stepping stone bridging mission phase 1 development and piloting and the second deployment and upscaling phase from 20262030pharos will have three demos in the atlantic using a combination of newly developed innovative nbs and imta tailored to the local context resulting in multiple biodiversity and ecosystem restoration benefits mission phase 1 these demos will also leverage key mission projects including ocean citizen climarest and ultfarms mission phase 2 pharos will also partner with h2020 ecotip to leverage and extend its project in a demo to reduce invasive species in iceland with edna monitoring mission phase 1 and 2pharos will extending trl advancement and rolling out leading mission projects across the aa basin including prep4blue mpa platform and network nettagplus and remedies fisher guardian and citizen litter entrepreneur programs and probleu eu blue school network platform for educationbridge to phase 2pharos will establish living labs early in the project in each demo and replication region securing participation for its cocreation approach across all relevant and necessary actors including different levels of government researchers and innovators education institutions small and large businesses investors and civil society