Dragon09/odtu_chatbot huggingface dataset:
joint industrial data exchange pipeline

currently economies worldwide are pursuing mostly a linear model of production which leads to massive material losses dependency on geopolitically instable states and volatile markets for primary resources a circular economy on the contrary seeks to counter this approach to preserve the value of utilized resources and materials as long as possible to use them as frequently as possible and to produce as little waste as possible european industry needs solutions to mitigate the barriers for industrial data reusability and facilitate the unlocking of value from data joint industrial data exchange platform is a place where industrial data is fused for interconnecting seemingly different sectors into the collaboration pipeline it builds upon the principles of industry 40 by adopting a coherent approach for the semantic communication between diverse actors aimed towards direct or indirect contribution to the eus climate neutrality goals of 2050 jidep is a landing place to any organization which has any kind of data obstacle to be addressed on its paths towards delivering more sustainable material product service or solution within jidep builtin tools are made available for unlocking the value of the data which can lead to the development of more sustainable solutions technologies and materials jidep is also an optimizing continuum covering the entire product lifecycle and steering it towards circular standards implementation at technological and regulatory levels finally jidep is a tool equipped with resilience frameworks for growing organizational and industrial capacities to withstand supply chain disruptions in short medium and longterm clauses as such jidep ingests industrial data and produces sustainability resilience and circularity artifacts for its participants
taming combustion instabilities by design principles

both the energy and aviation sector rely on gas turbines a combustion system continuously optimized since its invention during world war ii they constitute a main pillar for tomorrows energy and aviation mix to tackle climate change however fuel flexibility is stretched to its limits for conventional combustor designs combustion instabilities hinder a new generation of safe and lowemission gas turbines this calls for disruptive design approaches to enforce crucially needed stepchange technologies the overarching aim of tacos is to break the bottleneck of combustion instabilities by novel physicsdriven design principles based on latest theoretical findings the combustion community including myself has discovered exceptional points eps which are known from theoretical physics to feature intriguing counterintuitive physical properties our preliminary results confirm that eps i rapidly switch the combustor stability from unstable to stable and ii are wellcontrollable by both the acoustics of the chamber and the flame characteristics tacos takes a leap forward and exploits the unique properties of eps for the conception of novel combustors by 3 objectives a tailor the characteristics of both gaseous landbased gas turbines and spray flames aeroengines by carbonfree fuels hydrogenammonia and sustainable aviation fuels
a 64cuiibased radiotracer for diagnosing hypoxic conditions in cancer cells

cancer is a leading cause of morbidity and mortality worldwide development of new methodologies to early and accurate diagnosis of cancer should reduce these death rates hypoxia is associated with low oxygen levels in the cells which leads to an increase in tumor aggressiveness and to resistance to chemotherapy and radiation therapy therefore there is a compelling need to develop a biomarker for detection and imaging of hypoxic cells despite ongoing efforts to identify andor track hypoxia there is still no routinely used clinical biomarker or a radiotracer of hypoxia in the framework of the ercstg cuhypmech project we succeeded in developing a suitable highly selective and sensitive radiotracer based on 64cuii for petctpetmri imaging to report on the hypoxic conditions of cells this was achieved by monitoring the cellular copper transfer mechanism in human breast cancer cells specifically by identifying the various copperbinding sites in those proteins involved and identifying factors critical for proper copper transfer based on this molecularlevel insight into cellular pathways involving copper a lead compound was designed and characterized and termed 64cucyspheour lead 64cucysphe compound showed promising in vitro and in vivo results in breast cancer models in this poc proposal we would like to expand our in vivo experiments by testing our compound in additional cancers such as cervical and prostate cancers the main objective of this proposal is to complete all preclinic experiments needed before entering the clinic this will require us to show good identification of the tumor in various tumors of varied sizes from different cancers we will also have to correlate imaging intensity with hypoxia levels finally we will have to find ways to reduce preparation costs of our compound and seek subsequent investments either nondilutive through eic transition or dilutive through business angels or venture capital funds
ruralurban synergies emerged in an immersive innovation ecosystem

rurbanive will develop 6 ruralurban enablers rues innovations in six domains favouring bidirectional ruralurban synergies and a wellbeing economy a digital space the community store the prominent result of rurbanive will integrate the rues along with the community of practice suite of policies facilitating ruralurban communities to create strong synergies the community store will make possible synergies and recommendations online interaction dialogue collaboration and participation of ruralurban stakeholders ruralurban immersiveness rui exploiting the endless capabilities of immersion will promote experimentation and innovation in ruralurban areas immersive campaigns emerging from cocreation activities will be tailored to the potential of 7 ruralurban cocreation labs rucls and will enable ruralurban interactions through enhanced social connectivity and experimentation the 7 rucls will represent different geographical and sociocultural eu contexts and rui will ensure that stakeholders across specificities are included in prototyping testing piloting and demonstrating the rurbanive results a novel ruralurban innovation framework supported by social and technical innovations will enhance territorial governance and existing policy tools by equipping rucls with tangible outcomes on improving their ruralurban synergies participatory processes will support dialogue and cooperation enabling stakeholders to assess and evaluate approaches and scenarios that contribute further to developing synergies and recommendations the open call will fund projects developing their own rues based on the six rurbanive rue domains to be applied in other ruralurban areas and be available on the projects community store and the rui an inviting and sustainable ecosystem will be created around rurbanive to maximize the projects impact the broad application of the project innovations will be enabled through the creation of business model
high above the ocean unexplored molecular processes

oceans cover more than 70 of the earths surface and generate particles in the atmosphere that are viewed as a core component of the climate system especially due to their role in marine cloud formation and the strong control they have on their ability to reflect sunlight to space with our recent findings we have made great progress in documenting the formation of new particles by nucleation of low volatile gasphase species in the lowest altitudes of the open ocean atmosphere and its relation to water biogeochemistry nucleation is however expected to be promoted at higher altitudes in the marine free troposphere mft and the entrainment of growing particles formed in the mft is further suspected to be a major source of lowlevel marine cloud forming particles yet because of limited observations very little is known about mft nucleation which contributes to major uncertainties both in the assessment of presentday radiative forcing associated to aerosolcloud interactions and in future climate projectionsthe main purpose of this project is to identify the species driving mft nucleation and evaluate the impact of the process on cloud condensation nuclei ccn number concentration and ultimately on marine cloud formation and properties to achieve this goal we will first use an innovative experimental setup consisting of a nucleation chamber filled with natural free tropospheric air coupled to state of the art instruments to identify the nature of the nucleating species experiments will be performed on reunion island in the southern indian ocean which is particularly sensitive to natural aerosol sources these measurements will in a second step be used to initiate a modelling study that will further complement the observations allowing first to evaluate the impact of mft nucleation on the ccn population at the regional scale and then to study in detail the impact on marine cloud formation and properties over the open ocean
multisensory solutions for increasing humanbuilding resilience in face of climate change

climate change is leading to more frequent and severe extreme climate phenomena affecting both vulnerable subpopulations like children the elderly and the poor and healthy and wellbeing people to increase humanbuilding resilience against climate change active building solutions are often sought and promoted however they require a substantial energy use and thereby generate further environmental impact andor lead to adverse effects like increased noise or pollutions also these solutions protect from exposures rather than actually increasing human resilience on the contrary passive and hybrid solutions do not contribute significantly to greenhouse gas emissions but are often regarded as less robust and predictable and are affected by design challenges and potential rebound effects for example increased use of solar shading may affect lighting requirements and nighttime ventilation may influence indoor noise levels with this multidisciplinary multisectoral msca doctoral network music will address these challenges within the context of the existing european building stock and will provide solutions from the humancentred viewpoint 5 academic and 1 nonacademic beneficiaries together with 2 academic and 3 nonacademic associated partners will strive for educating the next generation of highly qualified young professionals able to provide future generations with more liveable and sustainable indoor and outdoor spaces in and management systems of cities by applying cuttingedge solutions multisensory and multidimensional research and industrial development 10 earlystage researchers will experience interdisciplinary and intersectoral training modules on science and technology as well as transferable skills and conduct individual rd projects for improved understanding and predictability of human reactions and innovative humancentric building and communityrelated solutions for increasing humanbuilding resilience in the face of climate change
spatiotemporal diversification of enteric nervous system

the enteric nervous system ens contains an extensive range of neural subtypes that collectively control essential gut functions largely independent of the central nervous system cns enteric neuronal diversity is critical for maintaining normal gut function and a selective dysfunction or local neuronal loss leads to gastrointestinal gi disorders as current treatments of ensrelated disorders are suboptimal development of novel regenerative approaches has the potential to significantly improve gi health for millions worldwide as a first milestone towards cellbased regenerative therapies the marklund lab recently established a molecular classification of intestinal enteric neurons and discovered that they diversify through a conceptually new stepwise principle during development the proposed project desteny will significantly expand on these discoveries and investigate how time and spatial context of developing gi tract controls the developing ens to acquire the appropriate neuron identities at the right time and region within the mouse gut desteny will integrate cuttingedge regular and spatial singlecell transcriptomics to identify potentially important spatiotemporal driver genes in the ens of the intestine versus stomach and oesophagus upper gitract while studies of the developing ens has been challenged by its inaccessible location within the gut wall desteny will overcome this limitation by the utilization a precise rapid and largescale gene manipulation strategy based on ultrasoundguided transduction of ens precursor cells followed by temporally controlled gene expression apart from transforming our understanding of the largest division of the peripheral nervous system and fundamental developmental processes desteny will open avenues for regenerative medicine in treating neurological gut disorders in particular the many affecting the upper gitract
understanding the functional role of immunerelated intercellular signalling networks during tissue development and cancer

intercellular signalling networks drive tissue fundamental processes immune cells present a wide range of versatile functions and distinctive plasticity which position them as tissue signallinghubs during tissue development homeostasis and cancer recent genomic advances have greatly improved our understanding of cell composition and states however investigation of the molecular signatures of intercellular crosstalk at the singlecell level remains limited exploring tissue development homeostasis and cancer from the point of view of immunecontrolled signalling networks has the potential to reveal novel therapeutic candidates with high biological and medical impact by applying functional assays alongside novel singlecell rnasequencing technologies and computational approaches as physically interactingcell sequencing picseq i propose to crack the functional consequences of the wholetissue signalling networks to revisit key developmental and cancer immunology questions1 what immunerelated intercellular crosstalk drives tissue development and cancer we will integrate scrnaseq and picseq analysis along mouse lung liver and kidney development and human carcinomas and apply largescale comparative crosstissue and crossspecies analysis exvivo and invivo studies to identify tissueexclusive and shared signalling during tissue physiology or cancer2 what can we study on tumorescape mechanisms based on physiological signalling networks we will perform development versus cancer largescale molecular comparisons invivo cancer models for functional perturbations and clinical validations to identify novel immunotherapy targets successful completion of the project will reveal novel cancer and developmental immunotherapy targets concomitantly findings will comprise a valuable resource for tissuemolecular signalling and will generate a platform for investigating biological enigmas by elucidating consequences of cellularcommunication
itec skynex atc platform

itec skynex atc platformthis project aims at evolving the itec platform architecture to support the virtual centre concept by making use of stateoftheart digital technologies and underlying architectural principlesthe platform evolution will eventually provide a consistent contribution to enhance safety resilience and scalability of the atm network allowing a more flexible provision of atm services this technical evolution will enable the full implementation of target architecture defined in the european atm master plan phase d through the instantiation of concepts such as platform as a service paas atm data service provision and highest automation level this project is proposing the implementation of the most architecturally significant changes defined in the itec v3 being already agreed by all itec partnersin addition the project will also continue the research of airspace delegation concept using virtual centre technologies focusing on the delegation of the atm services provision amongst atsus in a darchitecture this work will be used as the main reference for the activities of the device project related to d architecture requiring a strong coordination of both projects and alignment of their project plans
automatics in space exploration

a critical need for the future of space exploration is the ability to run artificial intelligence ai algorithms in situ under the harsh conditions of space in recent years ai has been revolutionising industrial processes and everyday activities primarily because the computing power has reached a level that enables these algorithms to function on the ground this is primarily due to the enormous investments in the development of highperformance graphical processing units gpu and of the optimised software needed for them these are delicate devices that cannot be deployed in the harsh conditions of space and the transistor density of the components of a gpu would be too extreme to resist the radiations present in space asap takes on the task of using processors that can sustain the radiation environment of space to transfer to space operation ai algorithms that so far could only be run on the ground asap will use the most advanced spacehardiness proven processors and develop the software needed to run ai algorithms on them asap will show proof of principle functionality and will reach trl4 asap focuses on five goals 1 working towards the identification and implementation of machine learning algorithms for the next generation space applications a suite of candidate algorithms has been identified and will be evaluated during the project for their possible deployment to space 2 identification and development of a computing platform for ml algorithms producing a prototype hardware using only components that can operate under space conditions 3 definition of a validation plan and its execution in a laboratory validation campaign reaching trl4 4 implementation of a virtual environment to provide support to the development of ml algorithms 5 transforming the future development of technologies and scientific instrumentation for space science and exploration missions bringing artificial intelligence to space missions
optimal solar systems for industrial heat and power

indheap project will demonstrate at trl7 that it is worth considering solar thermal st and photovoltaic pv energies in combination to address the heat and power needs of mid temperature industrial processes up to 250c as for it indheap will highlight the synergy between the different technologies with the development and integration of a core flexible thermal energy storage boosted by electric heaters named etes that is the key for a rational use of thermal and electrical solar renewable energy the project will rely on the development of specific methodology and tools tested on different case studies from industrial projects partners as to 1 reduce heat and power peak demands with an optimization of the current energy efficiency for the industrial process best use of waste heat and analyse of demands elasticity2 define the best share between st and pv based on technicalecoenvironmental criteria3 define the stpv hybrid systems architecture the presizing of components and the global control maximizing the use of solar heat and power 4 develop the specific components for the best integration and use of st and pv plants in synergy eg the flexible etes but also pv panels integration enablers low cost mid temperature solar collectors and a smart hybrid controller for heat and power joined managementa prototype st up to 300 kwth pv up to 20 kwp etes up to 1 mwh will be installed on an industrial process of lubricants blending owned by total energies in spain to validate the concept at trl7 with a one year test campaign the replicability of the demo is hundreds of equivalent sites finally from results gained a global upscaling and replication potential across the south europe and mena areas will be achieved to assess the societal and economic benefits of the concept to meet the net zero by 2050 ambitions indheap will support the eu in reducing dependency to natural gas while reaching climate targets
refugee political participation

if the 82 million displaced people across the world unchr global trends 2020 formed a country it would be the 20th biggest in the world but they are not a country apart from experiences related to poverty destitution insecurity and violence refugees experience exclusion from the political community and rights of citizenship the rpp projects overall aim is to transform how scholarship and policy conceives of refugees by placing their politics in the centre of the enquiry and studying how their voices are and can be recognised and empowered in a political context it will be the first interdisciplinary and critical scholarly study of refugee participation bridging work in political science critical legal studies and sociolegal studiesthis project will bring together will jones a political scientist who has conducted pathbreaking work on algorithmic decisionmaking and digital identity in the refugee regime with thomas gammeltofthansen director of the interdisciplinary nordic asylum law and data lab at the university of copenhagen to conduct the first systematic study of refugee participation this ambitious project innovatively combines political science law and data science to understand how refugees can and could be included and empowered in the refugee regime as it is transformed by the digital revolutionwe propose to conduct the first interdisciplinary and critical scholarly study of refugee participation this will contribute to scholarship in three key respects empirically it will provide multisited knowledge of this importantbutunderstudied issue conceptually it will move beyond uncritical activist or institutional approaches by applying rigorously theorised work from political science and law methodologically it will move beyond existing work by pioneering an analytical framework integrating multiple disciplines
skills for the european open science commons creating a training ecosystem for open and fair science

skills4eosc brings together leading experiences of national regional institutional and thematic open science os and data competence centres from 18 european countries with the goal of unifying the current training landscape into a common and trusted paneuropean ecosystem in order to accelerate the upskilling of european researchers and data professionals in the field of fair and open data intensivedata science and scientific data managementcompetence centres cc are seen as centres of gravity of os and eosc activities in their countries these entities can either be established national initiatives as is the case of icdi in italy or initiatives under establishment eg austria greece and the nordic countries or organizations which have the leading or mandated contribution to the os activities nationally ccs pool the expertise available within research institutions universities and thematic and crossdiscipline research infrastructures they offer training and support empowerment lifelong learning professionalization and resources to a variety of stakeholders including not only researchers and data stewards but also funders decision makers civil servants and industrythanks to their position at the heart of the above described multistakeholder landscape the ccs represented by the skills4eosc partners play a pivotal role in national plans for open science and in the interaction with scientific communities they also have close access to policy makers and the related funding streams the skills4eosc project will leverage this reference role to establish a paneuropean network of ccs on os and data coordinatingthe work done at the national level to upskill professionals in this field the skills4eosc cc network will drive the cocreation of harmonised trainer accreditation pathways academic and professional curricula and skills quality assurance recognition frameworks and learning material creation methodologies