Dragon09/odtu_chatbot huggingface dataset:
mutations of mtdna inheriting without perishing

mutations of mtdna cause mitochondrial diseases and are heavily implicated in the pathophysiology of ageassociated diseases and ageing low levels of mtdna mutations are universally present in somatic tissues of all humans and mtdna mutations have been reported to contribute to ageassociated diseases somatic mutations of mtdna often arise during the massive mtdna replication in embryogenesis and can accumulate postnatally by clonal expansion furthermore ongoing mtdna replication during adult life also contributes to the burden of mtdna mutations in mammalian somatic tissues mammalian mtdna is maternally transmitted without germline recombination and this asexual mode of transmission should theoretically lead to a mutational meltdown over generations the socalled muller ratchet at least two poorly understood mechanisms in the maternal germline counteract the transmission of mutated mtdna from mother to offspring ie the bottleneck mechanism and purifying selection the bottleneck mechanism ensures that only a fraction of the pool of mtdna variation in the mother is transmitted to the offspring the purifying selection functionally tests mtdna and decreases transmission of mutations in this proposal we will use powerful mouse models and completely new experimental strategies to study how mammalian mtdna mutations are inherited and how somatic mtdna mutations contribute to ageassociated disease and ageing maternally inherited pathogenic mtdna mutations often cause lifethreatening incurable diseases with failure of multiple organs in humans unfortunately the principles for inheritance of pathogenic mtdna mutations are often unclear and the knowledge generated in this proposal will give a better basis for genetic counselling furthermore the mechanisms counteracting a mutational meltdown of the nonrecombining maternally transmitted mtdna is a central question in biology of great basic scientific interest
design of novel magnetic graphene oxide nanozyme platform for theranostic applications

maggraphzyme aims at the development of a new hybrid multiplatform capable of triggering the intracellular production of reactive oxygennitrogen species rosrns for inducing cell death in cancer cells the proposed hybrid nanosystem based on the combination of magnetic nanoparticles mnps nitrogen doped graphene oxide ngo and a polymer plga shell will improve rosrns production due to the synergistic effects of all components regarding their catalytic activity as peroxidasemimetic nanozymes the control of this catalytic activity will be performed by heating the intracellular level via the activation of the constituent mnps through a remotely applied magnetic field thus a novel approach for intracellular rosrns production and quantification will be implemented furthermore with the aim of understanding the different cells pathways involved in the toxicity and the final death of the cells these hybrid system will be evaluated to investigate pathwayspecific rosrns induction of apoptosis and rosresponse mechanisms thus i will study signaling pathways which are known to be influenced by the production of these species to this end i propose detailed physical and chemical studies down to the atomic level of the mnpsngoplga systems for identifying the relationships between catalytic efficacy and active atomic sites within the structures these works will be developed by a motivated researcher with a strong background in mnps who will enhance and diversify his skills in advanced microscopy techniques and will acquire competences in biomedicine this multidisciplinary and innovative proposal will strengthen the collaboration between the hosting institutions will enable the european hosting institution to reinforce crucial competences in the understanding production of multifunctional materials and will contribute to improving oncological applications which is one of the most important scientific challenges with a high social impact
novel electrode coatings and interconnect for sustainable and reusable soec

the nouveau project will develop solid oxide cells socs with innovative la and pmgfree electrode materials solid electrolyte and interconnects with an overall reduced amount of ree 30 recycled y 5070 and cr 20 to this end advanced coating methodologies and modelling will be employed in combination with sustainablebydesign and recycling approaches integrated models will be adapted and developed to predict physicochemical propertiestoxicity endpoints in real life scenarios including multiscale models databased modelling shf spf userready modelling for industrial deployment ssbd tools standardisation and regulatory compliance reach updatesby addressing resource and energy efficiency through material design and waste management nouveau will create opportunities for increased circularity of raw materials lower climate impact and decreased criticality of solid oxide cells materialsto validate the nouveau projects objectives and their economic commercial and environmental impact a comprehensive set of assessment techniques will be used including lifecycle analysis cost analysis and social and ecoefficiency lifecycle analysis the assessment results will guide the projects efforts towards optimised resource efficiency and soc upscaling with improved stability benchmarked against the reference stateofthe ones more specifically nouveau will benefit from the complementarity and scalability of the green inks development in combination with spray printing slot die coating and convection and radiation drying the nouveau project draws on the complementary expertise of applied research centres and innovation driven companies including marion technologies coatema fiaxell and qsar lab in the field of materials design soc engineering and multiscale modelling including in silico methodologies machine learning artificial intelligence
secure decentralised intelligent data marketplace

the eu data economy has grown tremendously with forecasts predicting to reach 800billion euros in 2025 data are becoming the new currency being exchanged as products or services in marketplaces data markets are predicted to reach a size of 100billion euros in 2025 existing data marketplaces are centralised store the data on the cloud provide limited to no guarantees about data quality and they are governed by single entities that make the rules sedimark merges the expertise of a large team of experts to build a secure trusted and intelligent decentralised data and services marketplace based on distributed ledger technology and artificial intelligence sedimark enables distributed heterogeneous data within the eu to be easily and seamlessly linked shared and exploited for diverse business and research scenarios sedimark builds upon the concept of fair data ensuring that data are of the highest quality unbiased enriched and annotated so that they can be discovered accessed and easily reused sedimark includes a distributed registry of resources dataservices stored on edge systems close to where they are generated and where the data are cleaned labelled validated and anonymised security is applied with strong access control privacy techniques for data minimisation and purpose limitation exploiting blockchain for enforcing trust decentralised identities and data verification energy efficient ai techniques will be used for automated data quality management labelling and classification of data as well as for providing distributed analytics and advanced services on top of the data semantic interoperability based on common ontologies and data models will allow the easy and efficient discovery sharing and federation of heterogeneous data from multiple sources the system is built on top of existing platforms of the consortium starting from trl5 and will be tested and demonstrated in four real world scenarios reaching trl8
a new paradigm for highprecision top mass and jet substructure measurements at the lhc

we are in the era of precision collider physics where a major challenge is to accurately describe the effects of the strong interactions the precise determination of the top quark mass is one of the most important measurements in particle physics it is crucial for indirect searches for new physics and the analysis of the stability of the universe currently the measurement is plagued by theoretical imprecision including an overreliance on monte carlo simulations and the lack of a systematically improvable treatment of the physics of hadronization the process by which quarks and gluons are bound into colorneutral hadrons the same limitations also impact essentially all jet substructure measurements this includes measurements of the strong coupling which is another fundamental parameter of the standard model with the highluminosity phase of the large hadron collider lhc on the horizon addressing these problems becomes exceptionally timely and criticaltopmass will overcome these problems by 1 capitalizing on the pis recent groundbreaking work to exploit energyenergy correlators as a top masssensitive probe leading to a new paradigm and 2 exploiting modern effective field theory methods for developing a modelindependent framework to describe hadronization enabling precise jet substructure determination of the top mass and the strong coupling this avoids the systematic uncertainty from the usage of hadronization models it will have immediate applicability to a wide range of precision qcd measurementsthe key outcomes of topmass will be1 highprecision computations that enable a subgev top mass measurement at the lhc in a fieldtheoretic scheme2 a systematic datadriven approach for describing hadronization effects in modern jet substructure observables
comprehensive search for new phenomena in the dilepton spectrum at the lhc

while the standard model of particle physics sm has proven tremendously successful experimental evidence points to it not being a complete description of our universe but a low energy approximation of a more complete theory the searches for new phenomena np are therefore an important component of the experimental program of the large hadron collider lhc while there is no direct evidence for np at the lhc measurements of beauty hadron decays display a seemingly coherent pattern of deviations with respect to the sm predictions which suggest that np couples differently to three generations of matter the quarklevel processes responsible for these socalled flavor anomalies are related to dilepton production processes drellyan scattering through the crossing symmetry the measurements of the kinematics of the high mass drellyan hmdy process are therefore uniquely sensitive to a wide variety of np explanations of the anomalies the goal of this groundbreaking project is to provide for the first time the complete set of worlds most precise hmdy differential crosssection measurements covering not only the light lepton channels evvee but also extremely challenging third generation v and ditau ditto final states these measurements will be used to probe np at mass scales beyond the reach of direct production at the lhc through the sm effective field theory framework the innovative performance and trigger improvements of the ditto project will allow the ensemble of the proposed measurements to reach maximum precision boosting the possibility for a np discovery within the data sets expected to be collected by the atlas experiment at the lhc just as dilepton resonances such as the j and y mesons and the z and w bosons were crucial for the establishment of the sm the study of the same final state to be undertaken in the ditto project will help to pave the way for a better understanding of the physics processes beyond it
between canon and coincidence using datadriven approaches to understand art worlds

the becaco project applies a novel multidisciplinary framework to studying the provenance of ethnographic and archaeological collections moving away from the current focus in provenance research on single objects collectors or institutions the aim of the project is to reconceptualize provenance as the largescale study of the sociopoliticohistorical conjunctures that led to the translocation of cultural material to do so it introduces the concept of art world patterns an expansion and reframing of the idea of art worlds becker 20081982these patterns will be identified through an innovative combination of various datadriven methodologies by applying quantitative analyses network analysis and data mining on a large corpus of provenance data the project will explore the promises and limitations of different datadriven approaches in the context of largescale ethnographicarchaeological provenance research through this process the project will devise new models for provenance research in ethnographic and archaeological museumsthese conceptual and methodological advances will be mobilized through the study of indigenous latin american material from 12 museums in 9 countries the project will create a groundbreaking diachronic international and crossinstitutional understanding of the collecting of indigenous latin american material in europe in doing so the becaco team will reconstruct how through the formation of collections the indigenous latin american art world as it existed in europe between 18502000 constructed a discourse of art aesthetics and academic research that shaped how indigenous latin america is represented and understood in europe until today
molecular materials for passivation in large area perovskite solar modules

perovskite solar cells pscs have emerged as highly promising nextgeneration photovoltaic technologies distinguished by their exceptional combination of superior photovoltaic performance and costeffective manufacturing despite their remarkable potential the commercialization of largearea pscs remains a formidable challenge presenting a critical obstacle in the field of perovskite photovoltaics the core objective of this project is to spearhead the development of efficient and durable perovskite solar modules psms that are pertinent to industrially relevant scale we aim to demonstrate power conversion efficiencies of 23 and 20 on 100 cm2 and 800 cm2 modules respectively to achieve this ambitious goal we will adopt an interdisciplinary approach to devise a novel strategy for absorber and interface engineering on a large scale this breakthrough method will enable uniform crystal growth on a large scale resulting in perovskite films with high homogeneity and creating interfaces with nanoscale uniformity and robust interfacial adhesion in largescale modules the stability of these modules will undergo rigorous testing in accordance with iec and isos protocols simultaneously alongside the devicemodule fabrication and stability testing phases we will embark on fundamental investigations utilizing advanced techniques to gain a comprehensive understanding of the materials operational mechanisms within the modules this project capitalizes on the host labs extensive proficiency in perovskite module fabrication which is complemented by the applicants strong background in material design and synthesis this project will not only significantly enrich the fellows skill set but also instill invaluable leadership qualities and management skills poised to shape their future career
ngi zero core

we fund a large amount of third parties to review and upgrade the open internet architecture hardware software protocols to increase the performance of the network adapt it to new application requirements improve quality of service make it more resilient to security threats more energy efficient and respectful of the environment eg reparability recyclability and increasingly supportive of open and decentralised technologies and services with the size of the budget available and our methodology ngi0 core involves 150 000 to 300 000 person hours of directly funded human effort contributed to the public benefit and the good of the internet a multiple of that will be generated indirectly within the ecosystem around open source and standards ngi0 foundations is important to set the course of the evolution of technology and strengthening the role of europe within future developments in all this we benefit from decades of experience including significant experience gained within the various ngi efforts we have supported
supporting local economic development with business transaction data

this project aims to develop tools and solutions that turn valueadded tax vat records into an information system that can support evidencebased policy making and the development of regions industries and firms in general
automatic personalised makeup application

to meet societal expectations the average woman finds herself having to spend two years of her life sitting in front of a mirror applying makeup several wellknown issues make the selfapplication of makeup a challenging and inconvenient task that negatively impacts womens quality of life the majority of women report a lack of confidence in their ability to apply their makeup well the situation is even worse for women of color who are not offered enough variety of shades and for one in four women in the us with a physical disability impacting their ability to apply makeup yet the 511 billion dollar beauty industry continues to offer women no better alternative than the traditional makeup tools that have existed for decadesmodern women need access to a more convenient makeup experience and we believe that automation is the key that is why beautai is developing the worlds first automatic makeup application machine to help busy women achieve any makeup look in under four minutes by automated airbrush mechanics and proprietary realtime color mixing
regions4climate

increasingly frequent extreme weather conditions due to climate change concomitant with unsustainable historical resource use and management practices create the perfect storm threatening our livelihoods wellbeing and environment a transition towards resilience requires that we simultaneously address social inequalities and implement crosssectoral innovations to build social economic and environmental resilience to extreme events together regions4climate partners commit to addressing current and forecasted climate changerelated challenges and building more resilient european communities within an innovative socially engaged citizendriven paradigm we aim to develop smarter more inclusive more resilient regional ecosystems through crosssectoral innovation jointly created with stakeholders by and for people the development and implementation of crosssectoral strategies that incorporate combinations of social technological digital business governance and environmental solutions to common climate resilience challenges is at present constrained by knowledge deficits and uncertainties as well as sciencepolicystakeholder gaps regions4climate will bridge these gaps and address existing uncertainties by further developing adapting and integrating stateoftheart technical knowhow innovative tools and collaborative practices to support transparent evidencebased risk and vulnerability analyses and robust decisionmaking processes we will utilise system dynamic modelling to understand relationships among and tradeoffs between different resilience innovations providing tools for informed decisionmaking tailored to engage stakeholders and support european regions and communities exposed to significant climate change impacts new scientific insights along with a framework of interoperable tools methodologies and demonstrated solutions will enable european regions to develop their own resilience plans and transformative adaptation pathways
disrupting the cooling and heating industry a revolutionary green energy efficient and cost competitive magnetocaloric technology platform

magnetocaloric mc heat pumps can unlock sustainable heating and cooling by limiting ghg exhaust so far nobody has been able to create a commercially sustainable product due to high costs of rareearth materials needed magnetos technology has based on our patented composition of mc material for the first time ever developed a heat pump using affordable and available non rare earth materials our heat pump will enable scalability to the most price sensitive markets northern european countries with high energy costs incoming regulation on ghg emissions and an increased need of commercial cooling equipment due to urbanisation with eic support we will expand our current temperature span and run first pilots in commercial cooling sector by 2025 it will prove our product and business model increase market attraction and improve our further fundraising position we plan to reach breakeven by 2027 and a revenue of 85 million with a gross margin of 78 by 2029
clean and efficient cooling in vaccine transportation using rotating magnetocaloric effect

every year 15 million lives are lost worldwide due to insufficient access to vaccination while paradoxically over 50 of all produced vaccines are wasted mostly due to ineffective temperature control during storagetransportation the major challenges of the vaccine cold chain are the evermore strict limitations imposed on their aerial transport due to the safety hazards of refrigerant gases the highpower demand of active refrigeration devices in lastmile deliveries where the electricity supply is unreliable and the significant carbon footprint of high global warming potential refrigerantsthe magccine project aims to revolutionize the vaccine cold chain by developing a clean and efficient solid state magnetic refrigerator based on a novel approach the rotating magnetocaloric effect rmce a recently 2023 patent pending technology by project partners by reducing the amount of permanent magnets required the rmce is expected to enable drastic cuts in the devices production cost volume and weight while enhancing efficiency without the use of any high gwp or hazardous refrigerant gases highlighting its role as a key enabling technology for tackling vaccine cold chain challenges magccines goal is to develop and optimize a fully operational prototype for vaccine refrigeration in the 28 c temperature range which is required by most vaccines addressing the generation of clean cooling and clean cold chain transportation categories of this challengeto this end this project requires toplevel expertise on magnetocaloric materials magnetic field design thermodynamic simulations and heat pumps which are perfectly matched by the complementary expertise of the five academic institutions uporto cnrs u seville uaveiro uljubljana and the two industrial partners magreesource helium 3 our endeavors will be guided by an experienced advisory board including global key leaders such as who unicef cemafroid apirac iir medgree and addvolt
single pilot line operations

solo intends to pave the way for the commercial operations of next generation airliners proposing single pilot operations which are anticipated within the next decadeto this aim solo encompasses one single operational solution that will produce a trl 4 atm concept of single pilot operations this will initiated based on previous works initiated by airbus and atr with the support of french partners dsna eurocontrol enac and as well be based on the technological bricks developed during those previous rt activities in support to airbus and atr the maturation and validation of this concept will be done with the formal cooperation of dfs enairecrida eurocontrol dsna nats and indra indeed one major constraint for the trl 4 concept will be to reduce to the minimum necessary the impacts on atc tools and proceduresairline functions and tools will need to be enhanced to prepare and execute single pilot operations in addition to the major evolutions needed at the cockpit side not the purpose of solo several airlines had on an anonymous way supported airbus and atr for several years it is planned that a similar way of working will be done during the execution of the projectin the end the trl 4 concept of operations instantiated by a comprehensive sprinteroposed will feed further more specific rt activities and as well provide solid basis to various standardization and regulatory bodies such as icao easa faa caac