Dragon09/odtu_chatbot huggingface dataset:
migrant voices fighting linguistic discrimination from spaces of cultural and artistic production in spain

while linguistic diversity is promoted at the supranational level by the european union policies standardization and homogenization still prevail at the national level in most european countries in alignment with the one state one language nationalistic ideology in this context any speaker who deviates from the standard norm in particular migrants and their descendants are often misrecognized as linguistically deficient a discriminatory process that entails social economic and political consequences the case of spain is paradigmatic given the attested pressure towards normativity in the dominant variety of castilian spanish especially in monolingual regions like madrid drawing on interdisciplinarity this project migrantvoices aims to address this issue and open paths for social transformation the project will provide and analyze examples of instances in which migrant voices usually unheard have reached domains of public influence in society and have managed to challenge and transform the linguistic prejudices that affect them these instances of speaking out against linguistic discrimination coming from migrant communities have been deeply analyzed in the us but have not yet been studied in the european context to analyze these initiatives this action proposes an innovative change in perspective by focusing on artistic and cultural spaces which influence social practices and beliefs and which have yet to be explored drawing on ethnography and participatory methods this project will provide an analyzed corpus of successful experiences this will contribute to generating public knowledge on the possibilities to foster immigrants inclusion and participation in european societies which is one of the eus political priorities for 20212027 in doing so migrantvoices will also raise awareness of the role of language in discriminative processes and promote fairer individual social and institutional approaches to language
an inclusive toolbox for accelerating and smartening deep renovation

incube brings together 23 highprofile partners and two affiliated entities from 7 european countries envisioning to unlock the eu renovation wave through cuttingedge standardized lean integrated processes based on 4 key pillars of innovation 1 industrialization offsite manufactured solutions including the use of robots eg demolition telescopic cranes drilling and waste sorting so far applied only in industrial environments offering novel services eg anticollision area boundary waste tracking 2 novel selfres power producing and storage technologies products and environmentally friendly materials eg low gwprefrigerant heat pumps 3 digitalization dynamic digital twins of both products and buildings utilizing immersive capturing techniques eg laser 3d scanners and drones digitally merging innovative manufacturing processes with bims and 4 new market entrants organized under novel business models to allow for increased levels of collaboration and productivity the incube suite integrates digital tools across all 4 pillars enables for seamless coordination of different renovation phases while leveraging data streaming from multiple interoperable sources to accommodate tenants comfort and render buildings active energy nodes in the synergetic energy networks paradigm of the future solutions will be validated in 3 largescale demo sites 19100 m2 600 residents in 3 countries it es nl including a cultural heritage building key expected outcomes include among others reduction of waste streams and time needed onsite by 35 renovation cost reduction by 30 reduction of working time with hazardous activities by 50 energy savings 6gwhy 78 ghg reductions 1980 tco2eqy achieving an energy performance gap between asbuilt and asdesigned 20 and creation of 2 recs encompassing 2000 users all while accounting for social inclusion upskilling and enhancement of womens role in the construction industry
causal argumentative learning assistant

causal ai is widely perceived as crucial in the current ai landscape as it allows capturing causal effects amongst features in data rather than simple correlations causal discovery is an important aspect of machine learning as it paves the way towards achieving causal ai it amounts to extracting causal graphs from data encoding the structure of causal relations amongst features in data there is a gap in the stateoftheart in ai as concerns causal discovery in that most approaches are blackboxes hard to understand and explain and unable to engage domain experts to integrate and possibly contest the learnt graphs when they are misaligned with human knowledge and values carla aims at developing a platform for transparent explainable interactive and contestable causal discovery based upon an existing principled methodology and prototype as well as xai techniques developed within the erc advanced adix project carlas platform will support understanding the causal discovery process from data and experts while being able to influence it any developer or user of applications in highstakes domains will benefit from using this uniquely trustworthy platform carla aims to develop two demonstrators of the beneficial use of the platform in the highstakes domains of healthcare and finance to pave the way to commercialisation with a spinout
unlocking the potential of the mobility innovation ecosystems and networks

innomob will focus on the opportunities that initiatives networks offer to innovative and dynamic businesses through an inclusive mobility innovation european ecosystem business support framework the emerging sustainable mobility market will be used as the vehicle to examine the opportunities provided and develop mechanisms to support the deployment potential of companies in bringing innovations to the market quickly the project will use the services offered by the seven partner institutions but also through an enlarged network of initiatives and clusters run in the respective countries the specific objectives include to define the needs of the innovations stakeholders in the mobility sector to support the mobility networks initiatives apply an opening up strategy to create interconnected innovation networks on mobility and to implement joint awareness raising and communication campaigns to reach out to more stakeholders in different territories innomob will deliver a mobility innovation network min platform that will incorporate a stakeholder chain map intelligent platform function that will provide a holistic picture of the networks initiatives and their offer a search engine offerdemand marketplace space and communication exchange forum will be incorporated too the initiatives and networks will be able to offer their services through the platform with the aim to create more inclusive and diverse mobility ecosystems
artifying fibroblasts perturbation modelling in the lung tumor phase space to rewire fibroblasts for immunotherapy

lung cancer is the leading cause of cancer death immunotherapy improved survival rates but efficacy is limited to selected patients we recently discovered universal antigen presenting fibroblasts apfibros across human and murine lung tumors and showed that they directly stimulate cancerspecific cd4 t cells creating immunological hot spots that support immune rejection these studies achieved a breakthrough on the role of in situ cancer antigen presentation and proposed a novel model whereby tumors can sustain t cells independently of lymph nodes preliminary data suggest that lung apfibros help overcome resistance to checkpoint inhibitors for their immunotherapeutic exploitation of apfibros two bottlenecks must be overcome low numbers and incomplete understanding of their configurations we will integrate computational and laboratory experiments and work in parallel in human and mouse models to generate perturbation datasets across singlecellcell systems transcriptomicsepigenomics spatialtemporal levels and dissect the molecular landscape that regulates fibroblast states our ultimate goal is to unravel perturbations that can diverge cancerassociated fibroblasts to antigen presenting statesthe following questions are at the core of our proposal i how do diverse fibroblast states emerge and evolve ii which gene regulatory networks drive specificity of these states ii which are the functional modules that are driven by apfibros and how are they mechanistically explained iv how can we transdifferentiate existing fibroblasts to acquire antigen presenting states v how can fibroblast reprogramming help overcome immunotherapy resistancethe proposed research should help advance mechanistic concepts in what we term the adaptive immune mesenchyme decode the complexity of peripheral antigen presentation in tumors and beyond and promote targeting of the stroma for immunotherapy
the neural mechanism of scaleinvariant creative search

the human brain efficiently searches enormous mental spaces of thought for solutions to a given question how is this done the growing importance of creative search has sparked a surge of interest in mapping the relations between peoples creative search strategies and the structure activity and connectivity of their brain yet to date there are no coherent computational principles to bind behavioral computational and neurobiological findings together into a mechanistic understanding of creative search creativebrain uses two such computational principles scaleinvariant sensing and pareto optimality scaleinvariant sensing is essential for a robust search in environments with signals that span many orders of magnitude like in creative search pareto optimality asserts that individual differences stem from different balancing between competing tasks that need to be optimized and thus explains the utility of these individual differences creativebrain will employ stateoftheart computational and analysis methods from systems biology to infer the neural mechanism of creative search on the levels of function computations and neural implementation this will be the first comprehensive research effort that ties these findings to a mechanistic theory of creative search that also explains the utility of neural individual differences the project will result in a breakthrough in our understanding of how the human brain can efficiently search in vast spaces of thought on a broader scale creativebrain will open a new front in the interdisciplinary studies of the mind and brain offering a principled way to unite neurobiological behavioral and computational aspects into one holistic and mechanistic view by doing so it will contribute significantly to the promise of computational modeling for connecting different levels of inquiry of a higher cognitive function in the brain and can thus be extended to other cognitive processes and systems
percolation and conductivity in fluids containing rodlike particles

the perla project aims at developing electrically conductive fluids containing rodlike particles their novelty is based on the formation of dynamical systemspanning networks in fluid flow it is well established that rodlike particles do not simply align but do tumble and rotate in shear or elongational flow however the consequences of this tumbling on the percolation and electrical conductivity of suspensions are still unknown this behaviour is expected to promote collisions and electrical connectivity throughout the suspension perla will validate this fundamental hypothesis and provide thereby new concepts for the development of conductive fluids with low viscosity high and tunable conductivity systems of carbon nanotubes and short carbon fibers will be used as conductive brownian and nonbrownian rods they will be processed and optimized based on the longstanding expertise of the investigators in carbon chemistry and fiber processing the structure rheological and electrical properties of the suspensions will be characterized in depth in various flow conditions from dilute to concentrated regimes the latter will be of particular interest with the formation of liquid crystalline phases in which tumbling is also well established the basic knowledge gained in perla will be exploited in examples of applications including flow capacitors capacitive water desalination and soft electronic sensors and vibrational energy harvesters these applications are particularly promising regarding energy and environmental issues however they are currently limited by the use of highly viscous slurries made of spherical particles or of heavy and poorly stable liquid metals the fluids in perla will circumvent these limitations and provide new degrees of freedom due to original effects related to their response to oscillatory pressures or presence of particles of different sizes
lifting stellar structure and evolution to higher dimensions in the era of space asteroseismology

stars are the source of radiation chemistry and life in the universe models of how stars live are key ingredients in planetary astrophysical and cosmological research a star is a hot plasma rotating around an axis small stars like the sun rotate slowly but bigger ones with more mass rotate faster shaping them as flattened spheroids yet current stellar models simplify the flattening or treat stars as spheres during their lives using 1 spatial and 1 time dimension 11d rotation and magnetism induce transport processes in 3 spatial dimensions which change over time requiring a 31d treatment current agedating of stars is done from 11d models with uncertainties up to 1000 accurate ages of stars are the dominant missing ingredient to understand stellar and planetary evolution the emergence of life and the chemistry in our universe 4dstar will answer the fundamental question of how rotating spheroids evolve in time and build up their chemistry during their lives we will develop a new 31d theory of stellar rotation for flattened spheroids evolving over millions to billions of years from birth to death lifting stellar models to 31d can only be done now using asteroseismic data of thousands of stars in all life phases such data reveal nonradial oscillations or starquakes allowing us to infer internal stellar rotation magnetism chemistry and the ages of stars with 10 accuracy 4dstar will provide opensource modules to compute the evolution of rotating magnetic stars in 31d calibrated to asteroseismic observables of single stars and stars in binaries and clusters 4dstar brings a paradigm shift based on mathematical modelling astrophysics and computational science its breadth challenges and goals require a transdisciplinary integration of four teams led by an asteroseismologist a theoretician specialised in transport a hydrodynamicist and a stellar evolution software developer each with proven track records
building integrative single cell omics capacities using invertebrate tumor models relevant to human disease

scentinel aims to elevate the international status of forth greece by enhancing its genomics and bioinformatics capacities which are presently underdeveloped for this reason forthimbb twins with four major european research institutions the igbmc a component institute of the cerbm strasbourg the cnrs insitut jacques monod paris stockholm university and the irb barcelona our scientific vessel will exploit drosophila neural cancer models to address fundamental questions about tumorigenesis tumor composition and tumormicroenvironment interactions in the longterm our results may prove relevant for human cancer diagnosis and treatment achieving a tangible impact of wider benefit to society our action plan will include both networkwide actions handson workshops virtual and inperson network meetings and individualized training eg interlab visits training of facility personnel training of operational officers in research management dissemination and communication activities will target the scientific community conferences seminars highimpact publications authorities and financial stakeholders forums open days and the general public digital media science popularization presentations young and senior scientists of the network will benefit by engaging in excellent research and acquiring scientific skills in cuttingedge technologies as well as soft skills necessary for mobility across eu academia and industry via scentinel forthimbb will emerge as a leader in advanced genomics bioinformatics and will make its services available not only to the local biomedical community but also to the wider area of southeastern europe the upgraded forth ri capacities will stimulate retention and recruitment of highly motivated internationally competitive scientists improving its human capital the strengthened links among participating institutes will promote collaborations beyond the duration of this project and ensure success in future funding for innovative research
reshaping womens health through the understanding of gynecological fluids womec antibodybased ivd test based on 5 novel protein biomarkers quantified in liquid biopsy

womec is the future of endometrial cancer ec diagnosis it is an in vitro diagnostic test for ec based on 5 novel protein biomarkers that are analyzed in the fluid of a pipelle biopsy providing a 97 negative predictive value womec has been verified in 4 clinical retrospective studies in 530 patients that resulted in two patents a verified immunoassay prototype incorporating a proprietary algorithm and antibodies will be completed by january 2023 with clinical validation and commercialization expected for 2024 womec is targeted at public and private hospital systems clinical laboratories and will benefits woman undergoing the diagnostic process by providing a faster more accurate diagnosis with fewer complications by eliminating the need for invasive tests and by providing tumor histologic information to improve clinical decision making and optimize surgical treatment leading to a better quality of life increased life expectancy and reduced cost of care
role of the sirt7npmcmyc pathway in lung cancer

lung cancer is the second cause of death due to malignancy and diagnosed patients rarely survive beyond two years thus unveiling the molecular mechanisms underlying lung tumorigenesis is imperative for development of novel therapeutic approaches the nucleolar protein nucleophosmin npm plays critical roles in cancer progression and is often deregulated in human malignancies npm employs distinct mechanisms to control cancer cells growth including regulation of the protooncogene cmyc a transcription factor often aberrantly activated in lung cancer recent studies highlighted the fundamental impact of posttranslational modifications in controlling npm functions npm is a deacetylation target of sirtuin 7 sirt7 a member of a class of nad dependent histoneprotein deacetylases collectively known as sirtuins deacetylation of npm by sirt7 is fundamental to control npm subcellular localization and stimulate npmmediated cellular stress responses sirt7 also acts as a potent oncogene in different malignancies although through still poorly characterized mechanisms thus sirt7lc aims to characterize the impact of the sirt7npm axis on regulation of cmyc prooncogenic activities and its impact on lung cancer cells proliferation in vitro and in vivo as well as possible aberrant activation of this pathway in human lung cancers and its correlation with prognosis thus sirt7lc may lead to identification of novel molecular mechanisms sustaining lung cancer growth that could be targeted for therapeutic interventions dr alejandro vaquero a worldleading expert in the sirtuins field will supervise this project his competence in the field together with my expertise in characterization of mouse models of diseases will undoubtedly ensure successful realization of the proposed project expanding my scientific knowledge increasing my visibility as scientist and contributing to my development as a fully independent investigator
porous ionic liquids for sustainable energy

as the societys need for energy is increasing climate change points towards the need of finding sustainable renewable energy sources biogas holds the potential to replace natural gas as energy carrier thus reducing the reliance on fossil fuels while introducing renewables as dropin solution to existing infrastructure however existing technologies for the removal of carbon dioxide from biogas are energy intensive and considerably decrease the overall efficiency of biomethane as energy carrier the aim of the project porous ionic liquids for sustainable energy pilsen is to improve the energy efficiency of biomethane production from biogas while lowering the carbon footprint we will achieve this by capturing carbon dioxide during the purification of biogas and using it as a source of carbon we propose to develop a versatile chemical platform for carbon dioxide removal from biogas together with the subsequent conversion to valueadded chemicals this chemical platform will be based on porous ionic liquids which are a new and promising class of materials for processes involving gases preliminary results confirm that porous ionic liquids show carbon capture performances similar to benchmark technologies allowing for simultaneous capture and utilization with minimum energy cost the design flexibility and low environmental impact of ionic liquids bears great potential for the tuneability of our chemical platform hence we will combine theoretical and experimental approaches to identify porous ionic liquids suitable for carbon capture and conversion including the energyefficient isolation of products
knots and surfaces in fourmanifolds

fourdimensional smooth manifolds show very different behaviour than manifolds in any other dimension in fact in other dimensions we have a somewhat clear picture of the classification while dimension four is still elusive the project aims to further our knowledge in this question in several ways the genus function and its enhanced version taking knots and their slice surfaces into account plays a crucial role in understanding different smooth structures on fourmanifolds techniques for studying these objects range from topological and symplecticalgebraic geometric on the constructive side to algebraic and analytic methods resting on specific pdes and on counting their solutions on the obstructive sidethe proposal aims to study several interrelated questions in this area we plan to construct further exotic structures detect and better understand their exoticness in doing so we put strong emphasis on knots and their slice properties in various fourmanifolds ultimately we provide a candidate for an invariant which is a smooth and somewhat complicated generalization of the intersection form and we expect this generalization to characterize smooth fourmanifolds the novelty in this approach is the incorporation of knots and their slice surfaces in a significant and organized manner into the picture while it provides a refined tool in general this approach also touches classical aspects of fourmanifold topology through the study of the concordance group we plan to study divisibility and torsion questions in this group via knot floer homology definition of the concordance group rests on the concept of slice knots which is closely related to the ribbon construction we plan to further study potential counterexamples for the famous sliceribbon conjecture the proposed problems can also provide explanations of the special behaviour of fourmanifolds with definite intersection forms like the foursphere and the complex projective plane