Dragon09/odtu_chatbot huggingface dataset:
integrated interdisciplinary music practice and quantum computing technologies

emergent technologies open new avenues for industry and society but rarely create an open and inclusive space to think through their implications quantum computing qc currently represents a change in paradigm by offering a unique opportunity to rethink computation from its very inception in its effects and applications this is also the time and space to approach creative practice in an entirely new wayiimpaqct integrated interdisciplinary music practice and quantum computing technologies explores ways to expand and diversify the community engaged with qc and its epistemological and praxical connection to the creative arts with emphasis in music recent explorations in qc and music as well as in the visual arts domain have been pursued in isolation and even detached from contextual artistic practice and theory the lack of real integration that engages creative artists in the qc theoretical discussion and practical explorations makes the distance between art and science even wider and hinders the sustainability of a truly diverse society both socioculturally and technologicallyiimpaqct aims to develop and reinforce new interdisciplinary links connecting arts science and technology through 3 main intertwined researchwork dimensions i an artistic dimension promoting a network of creative practitioners engaging with qc while empowering them to be active participants in the field development ii a technologicscientific dimension focusing on the improvement and creation of practical tools and methods towards an intersectoral innovation and iii a curricular dimension that unfolds with the creation of study and research spaces in qc and arts as spaces for knowledgetheory construction as well as analysis and multiartistic creations this project uses principles of open access by engaging with a localglobal community of musicians and artists
roles of maize pip2 aquaporins in the structural organization of the cell

plasma membrane pm intrinsic proteins pips are aquaporins that facilitate the diffusion of water through cell membranes by regulating pip activity plant cells adjust water permeability rapidly and reversibly pip pm lateral diffusion is affected by the cell wall and actin also pmlocated pips interact with vap27s at the endoplasmic reticulum erpm contact sites epcs evidence suggests that pips get organized in interaction with other cellular structures however the functional relevance of these interactions has not been extensively studied the pipcontactsites projects main goal is to understand whether zmpip2s mediate pm interaction with other cellular structures er cytoskeleton and elucidate the physiological relevance of the contact sites under salt stress conditions our hypothesis is that pip2 interactions on epcs and with the cytoskeleton facilitate an efficient response to stimuli by participating in the structural organization of the cell our strategy integrates cuttingedge technologies for genome edition crisprcas9 and realtime monitoring of interactions split fluorescenceactivating and absorption shifting tag with advanced microscopy technologies ie confocal superresolution and correlative light and electron microscopy the originality of this project is to consider pips as multifunctional proteins channels and scaffold proteins the msca fellowship the great intellectual environment the infrastructure and the administrative support at the libstuclouvain the research and project managing experience of prof chaumont and my background in molecular biology will synergistically promote the success of the project the host group will benefit from hosting an independent creative and highly skilled scientist and i will gain experience and networking opportunities to shape my longterm objective of becoming a group leader
novel methods to identify endocrine disruption induced neurotoxicity

currently the incidence of neurodevelopmental disorders such as attention deficit hyperactivity disorders and autism spectrum disorders are increasing among children a trend that has been linked to manmade chemicals suspected of causing developmental neurotoxicity dnt despite this the current guidelines are insufficient to properly identify chemicals that are toxic for the developing brain and scientists across the world have recently called for better dnt testing methods neuromics will find new approaches to evaluate endocrine disruption induced dnt using cuttingedge molecular methods neuromics will apply exploratory omics in a powerful alternative model system to form novel hypotheses on how endocrine disrupting chemicals affect the brain we propose that lipids and myelination represent promising key events for endocrine disruptorinduced dnt and by using technologies such as highresolution mass spectrometry and matrixassisted laser desorptionionizationmass spectrometry imaging we will move the field from a point where hazard characterization relies on fluctuating hormone measurements to more reliable feasible and quantifiable molecular key events the project will utilize a representative of true frogs the cosmopolitan tadpole model american bullfrog rana lithobates catesbeiana to understand the causes of dnt and exploit this gained knowledge to establish adverse outcome pathways aops applicable for risk assessment of chemicals a european commission priority focus area and supporting the green deal neurodevelopment is highly conserved across animal species so the novel testing strategies will contribute to breaking down the wall between human and environmental toxicology this will enable for a better and more feasible identification and safety assessment of hazardous chemicals improve ecosystem health and ultimately reduce the neurodevelopmental disorders observed among children today
on the nature of autistic echolalia

echautism carried out jointly between care at boston university and acte at the universit libre de bruxelles aims at investigating the nature of echolalia in autism from a linguistic behavioural and neural perspective echolalia the exact repetition of the words of others is a salient clinical feature of autism that is defined by some as a senseless stereotyped and repetitive behaviour and by others as a communicative unusual form of language echautism will ask three specific questions in regard to the nature of echolalia in autism first it will investigate whether autistic echolalia should be considered as a symptomatologic manifestation of repetitive behaviours or a late onset form of typical speech imitation this will be answered by qualitatively and quantitatively describing and comparing the repetitive and the spontaneous speech production of a group of echolalic autistic preschoolers a group of echolalic autistic adolescents and a group of 2 to 3yearold typically developing children on measures of linguistic complexity communicative behaviour and brain activity second it will ask whether echolalia can function for some autistic children at least as a gestalt strategy to language acquisition this will be answered by evaluating the language abilities of the group of autistic preschoolers one year later to assess whether their speech became more functional and productive finally it will provide an update on the perception of and actions taken towards echolalia by autistic childrens primary caregivers this will be answered by disseminating a survey among speechlanguage pathologists specialised in autism and parents of autistic children echautism will have a significant impact on the researchers career by internationalising her research profile and training her in cuttingedge neuroimaging techniques its outcomes should be relevant for both scientific and clinical perspectives of autism
the mysterious bang a language and population isolate unlocks the secrets of interior west africas lost ethnolinguistic diversity

species are often the most diverse at their origins and all modern humans can trace their origins back to africa our ability to communicate through language defines us every human being speaks or signs at least one language we may never know when our current forms of language were first spoken or what speakers sounded like but we can be assured that primordial languages were spoken in africa yet a paradox presents itself with respect to the apparent lack of linguistic heterogeneity in africa the languages comprise only four of the worlds more than 150 families isolates languages with no known living relatives represent the missing links between todays homogeneity and the pasts diversitybangime may represent the only confirmed language isolate spoken today in interior west africa its speakers the bangande have resisted genetic admixture with neighboring populations for upwards of 9000 years the root of their eponym bang means hidden or secret in surrounding dogon languages whose linguistic and genetic ancestors are almost as mysteriousercbang will search for evidence of contact or inheritance between bangime and a hitherto unexplored set of west african languages and populations using computationallysupported methods our research team will conduct an indepth study of culturally significant and historically relevant loan words so that a statistician can incorporate these findings into stochastic models of language diffusion a geneticist will process the entire bangande genome to compare with west african populations from a wider range than thus far considered together we will perform a characterbased bayesian phylogenetic analysis of the dogon languages to estimate the time depth of the group in order to test settlement hypotheses and proposed migration patterns completion of this project will uncover traces of vanished ethnolinguistic varieties in west africa and our methods can be replicated to solve similar questions
integrated highspeed power systems for industry and mobile applications

this dn implements a multidisciplinary and innovative research and training programme bringing together different scientific fields and industrial participation to enable a new generation of doctoral candidates dcs to investigate and develop electric drives in the context of electrification in the transition towards zeroemissions electrification is one of the key assets in green transition and future sustainable worldwhile electrification offers one of the main solutions in reaching carbonneutral societies there is already now a lack of skilled persons in the field therefore there is an urgent need to educate young highly skilled engineers with a breadth of interdisciplinarity on designing propulsion machines and power converters to become eus future leaders in power electronic systems applied in renewable energy systems and electric vehicles evs the proposed network is timely in meeting the challenges bringing together the leading experts and providing best training opportunities to doctoral candidates dc this will make a step change in the eus key industry with potential impacts on other applications such as highspeed trains electric vehicles electric aircrafts and shipshighspeed technology enables high material and energy efficiency therefore hipo integrated highspeed power systems for industry and mobile applications research and training programme will focus on providing doctoral candidates dcs with relevant knowledge methods and skills across a wide range of disciplines around electric highspeed drives
advanced technologies for laser applications in space

the main goal of this era chair project proposal is to develop new capacities in the field of spaceborne laser research and applications in the region of central and eastern europe namely at the institute of physics of the czech academy of sciences fzu hilase centre czech republic by establishing an excellent international scientist professor of space systems engineering massimiliano vasile as an era chair and a leader of new research programme on advanced technologies for laser applications in space the new research group will focus on areas of laser use for space sustainability the new research group will focus on areas of laser use for space sustainability by preparing specific research and applications strategy roadmaps feasibility studies and project proposals in the abovementioned application area the atlas project will cut across all the aspects of the era chair in transferring knowledge at the same time the project will help to popularize spaceborn laser research and applications to broad publicas the chosen research area cuts across two complex fields laser science and space engineering the czech republics scientific heritage in laser science concentrated mainly at the hilase centre presents an unique opportunity for the development of laser space applications the research at hilase focuses on the next generation of highpower diode pumped solid state lasers hilase laser systems bring a unique combination of high pulse energy high repetition rate and high efficiency they are significantly more powerful more compact more stable and more easily maintained than those driven by oldfashioned flash lamp technology it all makes hilase the perfect engine for pushing even more the frontier of laser technology beyond its current limits while aiming for spaceborn lasers the atlas project will therefore open new opportunities for hilase and the czech republic to play a leading role in the development of space laser technologies
colloidal quantum dot molecules for display applications

displays are all around us they are in smartphones laptops tvs and cars and have become entwined in our everyday life with new features being added such as the augmented reality technology the market strives for constant improvement in display technology performance with better colors thinner formats and new functionalities the market share of quantum dot qd displays is constantly growing because of the pure colors emitted from colloidal semiconductor nanocrystals which enable a more vibrant and colorful viewing experience yet the current qd displays are inefficient not bright enough consume relatively high energy and have limited pixel resolution in the erc grant we have developed a generic method of binding and fusing two qds into a new class of cqdm coupled qd molecules this opened the path for the synthesis of novel cqdms with varying semiconductor nanocrystal monomers eg size shape and composition herein we propose to develop this concept towards the commercialization of cqdms as unique and novel materials for innovative high quality displays such cqdms with two different cores each tuned to a different color have the ability of dualcolor emission red and green which can be controlled electrically a pixeled layer of these novel materials can be inserted as the emissive layer in any of the present and futureday display technologies providing brighter and more stable and efficient displays alongside a much simpler production process compared to patterned separate redgreen qd pixels preliminary discussions with leading companies and investors have highlighted this potential signifying that the development of this technology can be of significant industrial value we plan to pursue this within the ercpoc grant by two main work packages focusing on the development of both the technological and business aspects aiming towards spinningoff a company or research and license agreement with a suitable chosen strategic partner
enabling advances in diagnosis patient stratification and treatment for dilated cardiomyopathy patients and families

dilated cardiomyopathy dcm is a heart muscle disorder characterised by thinning and stretching of the heart ventricles making it harder for the heart to pump blood systolic dysfunction this disorder with an estimated prevalence of up to 1250 predominantly affects younger adults it is associated with significant morbidity and mortality including heart failure and sudden cardiac death with endstage dcm being the leading indication for heart transplantationthe current disease burden in dcm is largely attributable to two important gaps in scientific knowledge firstly our understanding of the aetiology and genetic architecture of dcm remains limited hindering the utility of genetic testing in clinical patient management secondly there are limited therapeutic options for dcm patients existing therapies are generic and target symptoms no curative treatments exist apart from invasive heart transplantation and there are no approved therapies targeting underlying molecular disease mechanisms a fuller understanding of the genetic architecture of dcm and knowledge of the genes and genetic variants involved are critically needed to provide solutions for these unmet medical needsthe dcmnext consortium combines worldleading interdisciplinary expertise and resources of 8 investigators in the fields of dcm deep clinical phenotyping cardiogenomics cardiac transcriptomics artificial intelligence in silico drug target discovery and functional studies they will uniquely leverage their unparalleled cohort of 11750 dcm probands and relatives with extensive clinical and omics datathrough cuttingedge genomic and cardiac transcriptomic studies the project aims to 1 revolutionise genetic testing and patient stratification for more precise prediction of disease onset progression and risk of major adverse cardiac events and 2 accelerate development of novel therapies by identifying and validating targets involved in pathogenesis of dcm
probing and controlling ultrafast electron and ion dynamics in operating battery electrodes and interfaces

charge dynamics lie at the crux of electrochemical energy devices and inparticular batteries impacting everything from durability to capacity on mesoscopic time ns to s and length scales nm to mm we have a good understanding of charge transport related phenomena in batteries however when it comes to faster femtosecondpicosecond processes and those at nanoscopic interfaces our insight remains limited this is a critical problem in this regime lieathe individual electronicstructural steps in the redox chain that can cause electrode capacity loss via chargetransfer to inactiveunstable statesbdesolvation processes that inhibit fast charging through chemical imbalances at electrodeelectrolyte interfacescsluggish ionic hops limiting the use of many solidelectrolyte and electrode materialsin femtocharge i will take the conceptual leap needed to elucidate ultrafast interfacial dynamics in batteries by merging femtosecond spectroscopymicroscopy and operando battery science my novel approach is based on my pioneering work to optically image ultrafast spatiotemporal dynamics and their coupling to structure in nanomaterials and probing in the complex solidliquid environment of batteries i will leverage this approach to 1uncover optimal electronicstructural pathways for chargetransport in current and developing electrode materials 2quantitatively reveal potentials and solvation mechanisms at electrodeliquid electrolyte interfaces3use lattice vibrations to manipulate ionhopping in solid electrodeselectrolytesi will deliver blueprints for building new electrodeelectrolyte battery materials strategies for external stimulibased tuning of battery chargetransport and gamechanging operando tools for characterising chargedynamics particularly when they are stochastic or deeply buried ultimately the fundamental insights and new techniques of femtocharge will make controlling charges the future of electrochemistry
worlds first devicebased treatment for small abdominal aortic aneurysms based on revolutionary new treatment paradigm

the angiolutions device is a firstofitskind device stopping the lifethreatening progression of small abdominal aortic aneurysm aaa a pathological dilation of the aortaangiolutions awardwinning patentprotected solution leverages a fundamentally new understanding of aaa growth discovered by the founders at stanford university they showed that stiffness gradients between the compliant healthy aorta and the adjacent stiff diseased aneurysm serve as a motor for aaa growthbased on this principle together with key physicians we developed a minimallyinvasive nonactive aortic implant class iii the nitinolbased device is positioned adjacent to the aneurysm sack via simple catheterbased implantation it is specifically designed to focally increase aortic stiffness in the compliant aaa neck region thereby reducing stiffness gradients towards the stiff aaa sack that drive aneurysm growthhereby we achieve a fast lowrisk sizestabilizing treatment of small aaa
imperial science and the habitability of central asia and mesopotamia 18151914 a history of the societal consequences of changing environmental limits

following a summer where parts of europe flooded while others burned this research addresses a fundamentally relevant question what happens to societies when habitable places become uninhabitable the large scale effects of anthropogenic climate change are new but divisions of the world into habitable and uninhabitable regions are not and have long shaped humanity my project examines a pivotal part of this longer history by showing how between 1815 and 1914 british and french imperial scientists tried to measure the limits of life on earth in new ways especially via the new sciences of geology geography and ecology there is nevertheless a significant research gap in that previous scholars have generally used intellectual history methods to examine theories of environmental change proposed by elite philosophers based in europe rather than addressing the imperial contexts in which this knowledge was made bringing an innovative combination of global history and history of science methods to archival sources my project will close this gap by focusing on central asia and mesopotamia which became key to investigations into the societal consequences of environmental change eg the movement of the euphrates river causing cities to be abandoned examining the origins of these environmentally determinist imperial categories will simultaneously reveal their problematic legacies today eg the idea of afghanistan having an inherently violent geography this research thus aims to place scientific and cultural ideas of uninhabitability into their historical contexts and pioneer habitability studies as an essential interdisciplinary methodology for an age of climate crisis this will also allow me to enhance my research skills learning cuttingedge material culture and colonial archive methods and expand my impact and international profile under the expert mentorship of prof roland wenzlhuemer to secure an academic position at a european university