Dragon09/odtu_chatbot huggingface dataset:
legal annotations within scandinavia

the legal annotations within scandinavia laws research project will examine medieval legal manuscripts for notes left in the margins by readers these additions include evidence for the changing understanding of the law across the medieval and postmedieval periods the marginalia in these texts include reader reflections and erasures and i will examine these marginal annotations for insights into the ongoing reception and interpretation of the laws including the circumstances of its evolution this is particularly important because unlike the rest of continental europe medieval scandinavian legal manuscripts were less influenced by the bolognian and parisian law models and similarly the reader annotations do not follow the customary glossing patterns this provides an opportunity to examine a unique reading and legal culture that existed literally in the margins some of which will only be visible and legible now after centuries due my use of the multispectral imaging scanner at the arnamagnan institute the main objectives of my research project are therefore to 1 to examine the medieval legal texts in the arnamagnan manuscript collection for evidence of use by medieval and postmedieval readers 2 to develop a detailed record of the marginalia both standard and nonstandard present in the legal texts in order to track the changing understanding of medieval legal terminology 3 to consider the broader questions of literacy and the nordic legal cultures as seen through two important 18thcentury manuscript collections which serve as a representative sample of the time and 4 to produce an exhibition comparing the patterns of use on these medieval scandinavian manuscripts to those used read and annotated in medieval england and continental europe my research will be divided into two distinct work packages corresponding to year 1 and year 2 in the course of this i will submit two articles for publication and curate a major exhibition
a new highperformance and environmentally clean engine for heat pumps using thermoacoustics technology

heat pumps are the best sustainable solution for heating and cooling but they have performance limitations and are very expensive preventing them from having the desirable market tractionblue heart energy bhe has developed a disruptive patented technology based on thermoacoustics that significantly improves the performance of heat pumps with our solution heat pumps turn into flexible silent and affordable devices we do not use any hfcgases and our system is adequate for both new and existing housesblue heart leverages 15 years of rd from tno a leading dutch research organization and has been designed in close collaboration with leading oems to seamlessly replace the engine of every heat pump our scalable b2b business model will leverage the distribution channels of heat pump manufacturers ensuring a fast adoption by end customers and accelerating the energy transitionbhe has a multidisciplinary team of 15 people and is led by a highly experienced management team
growing connection for bio ecosystems

cobioe is project to interconnect innovation ecosystems to foster 40 industrial transition in the biopharmaceutical deeptech sector sharing competences information and opportunities with the aim of ultimately converging toward a common and inclusive european strategy for bioproduction support specifically the proposition will focus on the bioproduction sector that includes development of small molecules biologics drugs innovative therapeutics such as gene and cellular therapies high technology drugs based on cell and molecular biology and covers various applications in health oncology immunology virology rare diseases etccobioe will reach the following objectives provide a state of the art and exploitable overview of the european bioproduction value chain focusing on european national regional strategy or existing initiatives activities opening up the bioproduction field by reaching out to isolated actors and territories bringing added value to the chain building up bridges between sparse innovative ecosystems and initiatives opening up opportunities for isolated players promote bioproduction ecosystems the field and its potentialities in terms of green digital and social transition among various stakeholders and policymakerscobioe proposal includes 5 health clustersnetworks preeminent and pioneers in the field of pharmaceutical biomanufacturing each partner complements each other in terms of competence and the partnership covers almost all european regions from north to south and east to west including modest moderate strong and leading innovators moreover each partner benefits from an extended network of stakeholders from different technological sectors materials science artificial intelligence biotechnology blockchain robotics photonics electronics and quantum information and actors universities research hospitals funders
modulating immune responses to mitigate neuroinflammation bioenergetic decrease and cognitive decline in alzheimers disease

background and rationale alzheimers disease ad is the main cause of dementia with substantial socioeconomic burdens due to the absence of a cure understanding disease mechanisms and developing new therapies is crucial agerelated systemic and brain inflammation contributes to cognitive decline inhibiting prostaglandin 2 pge2 pge2 receptor 2 ep2 signalling has restored youthful hippocampal functions in ageing mice but its specific impact on adrelated deficits remains unclear aim we seek to explore the effect of ep2 inhibition on bioenergetic and cognitive decline in an amyloid precursor protein knockin appki mouse model of ad using neurobiology immunology and data science objective 1 we will compare the effects of brainpenetrant and nonbrainpenetrant ep2 antagonists on memory synaptic function glucose metabolism systemicbrain inflammation and amyloidbeta a pathology objective 2 we will study these effects in appki mice injected with ad brainderived pathological tau we will then assess the impact of peripheral immune modulation on adlike pathology spread objective 3 we will analyse the changes and interplay among synaptic dynamics microglial activity atau pathology progression after ep2 inhibition via realtime imaging methodology the study will involve various assessments including behavioural tests biochemical and immunohistochemical analyses multianalyte assays as well as multiomics approaches that combine transcriptomics and metabolomics additionally it will utilise two and threephoton microscopy for live imaging expected results we anticipate gaining valuable insights into a pge2ep2 inhibition effects on addriven deficits and b whether peripheral immune reprogramming restores brain functions beyond the bloodbrain barrier impact the project could yield novel mechanistic and translational outcomes guiding noninvasive therapeutic approaches to combat ad through peripheral modulations
a vaccine targeting eradication of malaria

malaria killed about 640 thousand people in 2020 largely young children in africa rapid recent progress has led to two antisporozoite vaccine developers planning who prequalification applications in 2022 these include the new high efficacy r21matrixm vaccine to be supplied at the required large scale and led by partners in this consortium in parallel recent progress with transmissionblocking malaria vaccines has led to substantial efficacy in a first direct skin feeding field trial this opens up the prospect of a twostage vaccine targeting both sporozoites and sexualstage parasites that should have a major impact on malaria transmission thereby enabling regional elimination and ultimate eradication we propose here to develop such a vaccine assessing both established viruslike particle vlp vaccines in potent saponin adjuvants and also exciting new thermostable mrna vaccines expressing the parasite antigens now showing high efficacy importantly we will adopt new vlp design technologies eg spycatcher bonding that allow bivalent antigen display to enable a single vaccine to protect against both the plasmodium falciparum parasite which causes most deaths and the more widespread plasmodium vivax parasite a lead vaccine candidate will be downselected based on wellstudied preclinical efficacy models and induction of functional transmissionblocking antibodies prior to gmp manufacture and a clinical trial in year 4the consortium brings together academics nonprofits and a wide range of companies with both leading technologies and access to small and very large scale gmp manufacturing capacity this programme builds on the recent success of several partners in the r21matrixm programme and aims to accelerate the malaria eradication agenda by providing the first vaccine to tackle both major malaria parasite species and confer both individual and community protection on the way to eradication
material science innovation for accelerated sustainable and safe implementation of carbon capture and storage

missionccs presents a timely and unique doctoral network designed to deliver the next generation of highly trained researchers and entrepreneurs in the field of material science specifically focused towards accelerating implementation of carbon capture and storage ccs technologies worldwide and ensuring the sustainable and safe operation of existing and future ccs systemsthe training network combines unique experimental system design and modelling approaches stateoftheart analytical technologies and technoeconomic analysis to deliver a new generation of researchers and entrepreneurs the programme of research training centres of delivering doctoral candidate researchers dcrs with worldleading technical expertise in material science and engineering relevant to the entire ccs process missionccs ensures that the subjectspecific technical knowledge of each dcrs is underpinned by intersectorial knowledge whilst also promoting wider innovation skills and relevant training on the technoeconomics of ccs developing experts with breadth of knowledgea central aim of the network is to forge a strong cohort culture by ensuring that peertopeer learning and mutual support become the norm in order to enhance experience researchled training activities are strengthened through a dynamic and interactive education based programme delivered by an internationally renowned consortium of academics and industrialists with complementary skills as part of the training programme subsequent to an introduction to ccs systems and the specific material science challenges dcrs will gain knowledge of system design and optimisation stateoftheart analytical methods theoretical modelling technoeconomics and understand the challenges of exploiting their research they will also acquire proficiency in project management communication entrepreneurship and innovation all essential attributes for any modern technical professional
dried fruits as a source of prebiotic oligosaccharides and soluble dietary fiber the case study of fig

health diets require diversification of nutrients supporting and promoting the traditional food products while keep finding new ways to their safeguard figs are nutritious and delicious products endowed with many healthbenefiting nutrients drying contributes to widen their availability diversify trade and promote their nutritive value recent research trends show that oligosaccharides os and soluble polysaccharides nondigestible by human gut enzymes are of great interest for their health benefits and natural nutraceutical value although dried figs nutritional quality has been well studied there is a lack of knowledge on the matching of the os and soluble dietary fiber sdf structural features and their potential health dietary benefits prosfig project aims at valorizing dried figs os as prebiotics and polysaccharides as sdf as an msca fellow i propose to study at uaveiro the i drying processing consumer perception and conservation of figs ii extraction and chemical characterization of dried figs os and sdf this will allow to perform a secondment at uporto to iii monitor the bioavailability and bioaccessibility of the os and sdf and their interactions with fig polyphenols and a second secondment at uminho to iv carry out in vitro assessment of prebiotic properties this interdisciplinary approach in a relevant food research topic draws a unique skill set and stateoftheart in four different but complementary fields 1 drying technology for producing healthy foods 2 consumer acceptability of traditional dried fruits 3 food biochemistry via the application of spectroscopic techniques as tools for os and sdf characterization and 4 bioengineering for evaluating the physiological aspects of os and sdf related with gut microbiota the integration in these universities dissemination and communication programs as well as in their training activities will support me to develop my career
from research optoacoustic novelty to imaging established in routine diagnostics

multispectral optoacoustic tomography msot is an innovative biomedical imaging technology that allows for molecular imaging in deep tissue this noninvasive technology enables assessment of the concentration and distribution of a variety of clinically important molecules in the body and uniquely delivers information of eg oxygenation inflammation and fibrotic changes msot has already demonstrated significant scientific and clinical value across a range of diseases and applications making it a promising tool to diagnose diseases and monitor treatment response despite these early successes the technology is not yet commercially viable on the broad clinical market and currently remains effectively confined to a research environment frontier will provide ithera medical the means to translate an optimized msot system msot frontier from a research environment to application in routine clinical imaging thereby providing clinicians worldwide a powerful new diagnostic tool
safe and alternative vver european fuel

the security of supply of vver nuclear fuel has become and will remain of vital importance in countries operating vvertype reactors and due to the strongly interconnected european grid network this is also instrumental for europe as a whole the aim of save project is to strengthen vver fuel security of supply in europe and ukraine by qualifying a reliable and safer sovereign vver440 fuel design by developing a fasttrack licensing path and improving european capabilities for vver440 fuel design qualificationthrough a strong european collaboration a large qualification campaign will be performed within european test facilities to assess the performance of the new safer and sovereign vver440 fuel assembly design save will prepare inreactor qualification with mutualised lfas lead fuel assemblies programs which will significantly accelerate design readiness for fuel reloads save will also define the plans to enable fully european manufacturing route and address the needs on core monitoring systems to initiate the next steps of development to contribute to these objectives and increase the security of supply in europe the save project is gathering 17 partners from 8 european countries within a consortium composed of experienced and highly qualified european actors in nuclear fuel and vver technologies including nuclear utilities tsos research entities leading industrial actors and universities
multidisciplinary multisectoral and multinational training network on digital biomarkers for supraventricular arrhythmia characterization and risk assessment

insideheart brings together universities companies and hospitals from countries italy finland france israel netherlands spain and sweden with the main scope of establishing a multidisciplinary network to tackle the design and the earlyphase validation of digital biomarkers specifically targeting the diagnosis of supraventricular arrhythmias svas and their associated potential for adverse risk assessment via the joint combination of signal processing artificial intelligence and nonclinical devices this will be achieved by performing excellent research through a unique doctoral training without walls among fieldexpert academic industrial and clinical entities the composite nature of the insideheart network ensures a highly qualified training and research infrastructure for the specific goal which aims to generate a new profile of researcher with multisectoral expertise able to fill the existing gap ie the absence of digital biomarkers for svas reliably estimated with nonclinical devices taking into account basic research clinical needs and business interests research and training are designed to consider relevant aspects such as public concern of private data management gender and ethics related to svas all according to responsible research innovation principles and open science practicesall activities in insideheart are designed to pursue innovation in three domains i educational domain by implementing a new multisectoral paradigm of phd training to shape modern professional researchers with crosscompetencies in the field and able to accelerate the translation from basic science to market and clinics ii basic science domain by producing new knowledge about digital biomarkers by means of a multisectoral approach to explore the complex aspects related to svas and iii technological domain by developing new datadriven and modelbased methodologies to compute digital biomarkers and support the clinical decision
combinatorial and geometric methods for mapping class groups of surfaces

given a mathematical object a common theme is to study the symmetries of that object in this project the objects are compact topological surfaces and the group of symmetries is the mapping class groupin this project we will investigate simplicial graphs associated to surfaces which have proved to be key tools in the study of both the algebraic and the geometric structure of mapping class groups studying the geometry of groups has proved to be a profound way to study their algebraic properties we will focus on a graph called the pants graph whose vertices represent pants decompositions of the surface collections of homotopy classes of simple closed curves that cut the surface into spheres with three holes the pants graph is significant not only in the study of mapping class groups but also in studying the hyperbolic geometry of surfaces and 3manifoldsthe first part of the project is to understand how distances between vertices in the pants graph are related to the number of intersections between the corresponding pants decompositions for a related graph the curve graph it is known that the distance between two vertices is bounded above by a logarithmic function of the number of intersections but the methods do not immediately generalise to the pants graph we will also investigate questions of computational complexity around computing distances in the pants graph this part of the project will include a secondment at a computer science departmentthe second part of the project is to investigate maps from the pants graph to itself which preserve distances up to bounded error such maps are called quasiisometries in a general metric space the group of quasiisometries is much bigger than the isometry group but for most pants graphs bowditch proved that the two groups coincide a property called quasiisometric rigidity we aim to prove that the same is true for three of the remaining unsolved cases
strategic energy technology plan conference 2024

the hungarian ministry of energy presents this proposal to host the 18th set plan conference in 2024 which will take place in hungary during the hungarian presidency of the eu the conference will be held in budapest on 1415 november 2024 and will be organized by the hungarian ministry of energy and the european commission the general theme of the conference is energy rd for resilient autonomous and competitive european energy system the agenda includes several thematic parallel sessions and high level panels as well in the following areas commercialisation of innovative technologies industrial decarbonisations geothermal energy energy storage hydrogen skills we are expecting high level speakers from the european commission and the hungarian minister of energy to open the conference the main goals of the conference are 1 enhancing cooperation and synergies between national and european policies 2 facilitating collaboration within the energy ri 3 gathering the most promising results of the energy ri
sustainable marine energy and ecosystem resilience advancement through digital technologies and realtime crisis management

the project aims to strengthen eu efforts towards achieving climate neutrality and achieving green energy and environmental targets seadream plays a crucial role in making sure marine energy is utilized sustainably and coastal environments are preserved in line with eu policiesthe development of a highresolution water quality data service at sea is at the core of seadreams mission data such as these are crucial to addressing specific questions regarding maritime renewable energy generation and storage the project integrates local monitoring data and advanced modeling through the development testing and demonstration of novel downstream information services in an operational mode as a result of this integration marine activities related to the generation and storage of energy are improved and environmental objectives are not compromised by harnessing advanced data and fostering collaboration across sectors the project aims to contribute significantly to the eus environmental and energy targets promoting a path towards climate neutralityin order to achieve seadreams vision a coordinated research program that thrives on collaboration is implemented in this program leading teams from academic and private sectors are seconded within and outside the eu collaborations are enhanced by periodic workshops and summer schools that disseminate the latest findings and promote marketrelevant knowledge applicationit is designed to foster the advancement of knowledge and career development for both experienced and early career researchers and professionals to ensure this secondments and training activities are structured to ensure a comprehensive approach to learning and development additionally the seadream consortium includes nonacademic partners from various stakeholder groups which facilitates direct application of project results