Dragon09/odtu_chatbot huggingface dataset:
late lifeapplicable enhancement of longevity and fitness

aging represents gradual organismal decline driven by accumulation of cellular and molecular damages including dna damage and metabolic failures at young and middle age these damages are mitigated by tailored repair systems such as autophagy and dna damage response the repairs can be triggered through adaptive stress responses induced by antiaging interventions such as dietary restriction dr and dr mimetic metformin recently we found that loss of metabolic plasticity and repair activities due to aging abrogate longevity benefits of adaptive stressors at old age specifically we found that aginglinked failures of mitochondria and lipid catabolism limit metformin benefits and confer metformin toxicity in late life and others showed comparable limitations for dr and exercise our findings demonstrate that antiaging treatments do lose efficacy in old organisms and new approaches are required to promote healthy aging in late life here we will use multiomics and functional tests in c elegans shortlived killifish and longlived mammals to a probe the origin of aginglinked adaptive failures and b find molecular and therapeutic solutions for overcoming these failures omics tests and survival screens will be used to uncover mechanisms of intrinsic resilience against late life toxicity of metformin and other adaptive stressors in nematodes additional omics data will be analyzed to probe adaptive basis of the exceptional mammalian longevity in nmr and whale followed by attempted replication of uncovered differences in shorterlived species nematodes and fish by drugs and gene changes with an outlook of triggering superior stress resilience and metabolic plasticity in late life our expertise will allow testing late life responses to diverse adaptive interventions from moderate genotoxic stress to dr mimetics and microbiome manipulation this innovative program will illuminate novel treatments for healthy longevity that are not limited by aging
a complete biomethane set from agricultural byproducts to energy a new concept for the exploitation of agricultural residues

nowadays the construction of digesters for biogas plants is made of steel or concrete which is highly expensive and not ecofriendly recent changes on eu directives on lowering incentives for biogas production have excluded sophisticated solutions promoting the choice of simple innovative and costefficient solutions alvus proposes a new construction philosophy for the digesters based on the ecofriendly solution of mechanically stabilized earth mse our solution provides the following advantages i realization of larger volumes at a drastically reduced cost 55 capex savings compared to traditional concrete digesters ii lower co2 emissions up to 85 reduced environmental impact and better incorporation of the plant in the agricultural landscape and iii easy and quick construction thanks to this eic project alvus will be able to develop validate and commercialize a disruptive innovation revolutionizing the entire biomethane market
revolutionizing ai in drug discovery via innovative molecular representation paradigms

artificial intelligence ai in the form of deep learning is driving unprecedented progress in numerous fields eg for protein structure prediction and organic reaction planning in drug discovery and chemical biology such progress is an evolution rather than a revolution several tasks still await to be solved by ai eg accurate structureactivity and activitycliff prediction and design of structurally innovative chemical matter increasingly complex deep learning approaches are leading to progressively smaller gains in model capabilities calling for a revolution in ai for drug discovery the springboard for this project is a striking observation while novel deep learning algorithms are in continuous development the input raw molecular representations they rely on eg smiles strings and molecular graphs have not considerably changed in the last four decades limiting the amount and quality of chemical information learnable by ai the potential of capturing more sophisticated chemical information better into a new molecular language is still untapped and bears promise to revolutionize molecular ai reminder will break with traditional approaches and shift the object of study from increasingly complex algorithms to novel molecular representation paradigms for ai reminder will be an agent of change in the molecular ai landscape by developing a new representation framework at the interface between method development and experimental validation reminder will disrupt the potential of ai to a navigate complex structureactivity landscapes b design innovative bioactive molecules from scratch c leverage binding pocket information for molecule discovery by transforming the chemical information captured for ai we open opportunities to develop more efficient models and solve open scientific challenges reminder will create the basis for exciting new technology in the field of deep learning for drug discovery and chemistry at large
deciphering fibrosis reversal mechanisms in chronic blood cancer for identification of novel predictive and therapeutic strategies

fibrosis is estimated to be involved in 45 of global mortality and currently no specific therapies for fibrosis in most organs exist one central and controversially discussed question in the field of organ fibrosis is is fibrosis truly reversible in rewindmf i will address this biologically and clinically highly relevant question in a prime example bone marrow fibrosis in a chronic blood cancer called primary myelofibrosis pmf in pmf hematopoietic stem cells become mutated and activate fibrosisdriving cells fibrosis reversal in pmf is possible through allogeneic stem cell transplant asct however the majority of patients are not eligible for this highrisk procedure alternative fibrosisreversing strategies are not available leaving this patient group without any treatment optionmy specific aims in rewindmf are 1 to gain spatiotemporal insights into fibrosis reversal and mutant clone elimination mechanisms to predict which patients will benefit from asct and to identify therapeutic targets 2 to understand how blood cancer is maintained in the bone marrow and later the spleen stroma in order to find new ways to reverse fibrosis and eradicate the cancer cells and 3 to validate fibrosis reversal mechanisms and translate them into clinically relevant therapeutic strategies what makes rewindmf unique is the holistic benchtobedside approach starting from a stem cell biological hypothesis tested by innovative murine models and stem cell approaches advanced by a broad interdisciplinary expertise with novel single cell spatial genomic and computational technologies to dissect mechanisms of fibrosis reversal and develop therapeutic approaches which go beyond pure target identification the integration of all these technologies in clinically relevant specimens with followup data and large independent validation cohorts will truly revolutionize the prognostication and personalized treatment of patients with mf
ecofriendly extraction of flavonoids from barley waste using deep eutectic solvents for sustainable resource utilization

brewers spent grain bsg is a significant byproduct of beer brewing accounting for 85 of the waste produced and 31 of the original malt weight therefore there is a need to explore various recycling methods for this residue and transform it into valueadded products the objectives of this proposal align with several un sustainable development goals as they address sustainable food production and sustainable consumption focusing on health and wellbeing in this study we aim to utilize the bioactive phenolic compounds present in bsg to improve the shelf life of meat products to achieve this we will use environmentally and socioeconomically innovative methods for the valorization of bsg by using deep eutectic solvents des for the first time the use of environmentally friendly solutions for the extraction of bsg flavonoids will present improvement in terms of cost safety and environmental friendliness compared to existing methods for extractraction optimization of extraction conditions temperature solventtosolid ratio extraction time ph will be carried out to improve the selectivity efficiency and purity of target compounds des a solvent will be synthesized to selectively promote the extraction of rutin proanthocyanidins and catechin extract with phenolic acids an important aspect of this work will be to evaluate the toxicity of both the des solvent and the extracted compounds to ensure their safe use a number of analytical techniques will be used to evaluate the extraction efficiency of the flavonoid compounds primarily highperformance liquid chromatography hplc in combination with mass spectrometry ms in addition various methods will be carried out to evaluate the antioxidant profiles of the extracts finally the proposed project will demonstrate the use of the extracts in red meat products pork and beef and evaluate how these extracts can positively influence the shelf life and sensory properties of such products
urban bordering an ethnographic study of the ghetto package in denmark

at a time when migration is increasing many eu countries still struggle with fully accepting migrants and other minorities in this context increasingly member states introduce laws and regulations that police borders and reinforce social boundaries and as a result undermine the idea of liberal democracy these practices often labelled bordering constitute attempts to control and order the unknown or undesired subjects while much literature has dealt with this it remains understudied how bordering works in and through urban planning and housing the proposed project addresses this lacuna through an interdisciplinary analysis of such a practice of urban bordering the ghetto package in denmark ie a set of laws implemented to break up migrant parallel societies and enforce social mixthe proposed project further develops existing studies dealing with bordering by linking three scientific strands of literature anthropological criminology urban studies and migration methodologically it will rely on participant observation focus groups lifehistories and semistructured interviews in two different housing areas affected by the ghetto package in denmark this way it will complement the existing analyses on the normative and discursive elements of bordering with an ethnographic account of its implementation and social and political consequences likewise focusing on an iconic liberal democracy like denmark will elicit knowledge on potential societal effects regarding citizenship and belonging in the eu academically the project will benefit from the placement at the university of copenhagen the prominent research centre the centre for global criminology and a secondment at the inspiring research environment at the amsterdam institute for social sciences research university of amsterdam
multimaterial additive manufacturing for lightweight and thermal management

the 26th climate change conference has highlighted the urgent need to reduce global carbon dioxide emissions to limit global warming the transport sector accounts for approx 16 of the global carbon emissions and has identified fleet electrification as the primary route to achieving climate neutrality however the main challenges are the current weight of components and the cost of new systems to ensure efficiency and longterm sustainability as a result the industry has recognised the need for transformative technologies and production methods to develop lighter more efficient and costeffective solutions to enable this transition and achieve climate neutralitywith their outstanding mechanical strength carbon fibre composites cfc have been increasingly used to replace metals in products requiring lightweight features such as aircraft or highperformance vehicles however due to the traditional manufacturing process and poor thermal conductivity the use of cfc has been limited to structural applications for example batteries electrical motors and power electronics where power losses need to be efficiently dissipated typically require separate heat exchangers resulting in heavier and less costeffective solutions that still utilize bulky designs and heavy materialsthe vision of multhem is to develop a reliable and validated additively manufactured am cfc process with enhanced thermal conductivity with different material combinations and nanotechnology this innovative approach will allow the development of components such as battery and motor housings with dual functionality comprising structural and cooling features and with a more costeffective approach than traditional methods this solution will enhance the product performance first by the weight reduction achieved by designs that only am enables and second by using cfcmetal structures with enhanced thermal conductivity strategies lighter and stronger than aluminium or steel
improving access to services for victims of domestic violence by accelerating change in frontline responder organisations

in combatting domestic violence progress has been made however policy implementation remains slow and domestic violence mostly remains underreported by the victims and underdetected by the frontline agencies improve project develops several tools to increase reporting and detection of domestic violence by empowering the victims to understand their rights for services and justice and by supporting police authorities civil society organizations and other frontline responder organisations to enhance their competencies to utilize innovative solutions that enable and accelerate policy implementation improve will develop conversational multilingual ai chatbot aino that provides the victims immediate advice and risk assessment as well as guidance towards the available service provisions the performance of ai chatbot will be consistently improved by machine learning using inputs from the victimsurvivors improve will support the planning and decision making of policy makers and managers to fully utilize innovative solutions in the priority areas in order to accelerate policy implementation and enhance positive operational outcomes through effective application of tools procedures and measures to combat domestic violence improve will address frontline responders training needs by designing training materials covering sector specific and crosssector contents supported by innovative teaching and learning methods improve will construct and deliver targeted awareness campaigns for the victims their social environs and community representatives as well as frontline responder practitioners managers policy makers and academic experts innovations produced by improve are based on applied research that constructs a pioneering conceptual approach that is able to address diverse identities of the victims the underserved vulnerable and marginalized individuals and multiple forms and situations of domestic violence
neutrons electrons and xrays serving the transition towards a sustainable environment doctoral programme

nextstep will train 36 young and enthusiastic researchers to exploit the unique and transversal capabilities of analytical research infrastructures ris in tackling the challenges associated with sustainable development and industrial competitiveness in the areas of health digital industry space climate energy and mobility and food bioeconomy natural resources agriculture and environment which are at the heart of horizon europe these skilled researchers will be able to explore materials science chemistry biology and engineering and environmental sciences with unprecedented precision in space time and sensitivity using the ri techniques they will also be trained in complementary skills in innovation entrepreneurship and leadership providing them with the fluidity to be comfortable in all research and career settings at the heart of nextstep are the complementary and sophisticated analytical xray neutron and electron microscopy techniques available at the cuttingedge european ris european synchrotron radiation facility esrf xray synchrotron institut lauelangevin ill neutron source and edream advanced electron microscopes the academic research and technology organisations rto and industrial partners for each nextstep dc topic will be selected through europewide open calls for challenging and rewarding dc projects and will be included as associated partners this will create an outstanding geographicallydiverse and inclusive study programme fostering a crossborder knowledgetriangle network far beyond that of the recruiting institutes themselves nextstep graduates will be poised to become the drivers in future efforts to exploit the exceptional capacities of analytical ris and transform science output into disruptive solutions the graduates will have influence and impact for decades to come as they progress in careers be they in academia industry stakeholder or ngo organisations
diabetes lower extremity complications research and training network in foot ulcer and amputation prevention

dialect aims to combat diabetic foot disease through personalised medicine by establishing an innovative international interdisciplinary and intersectoral research and training effort that will deliver the next generation of leading entrepreneurial and creative scientists to reinforce the european innovative workforce this is both timely and urgent illustrated by that the burden of diabetic foot disease is in the top10 of all medical conditions and emphasized by the fact that every 20 seconds someone in the world loses a leg because of foot disease currently we lack success in delivering the right treatment to the right person at the right time to prevent foot ulceration and amputation we will provide unique worldclass interdisciplinary and intersectoral training to a new generation of highachieving dcs in the areas of biomechanics activity behaviour and footwear related to diabetic foot disease a wellbalanced consortium of academic industry healthcare and implementation partners will deliver the carefully designed dialect training network comprising training through research structured networkwide training events intersectoral secondments and future work skills training this will result in a paradigm shift towards personalised medicine that goes beyond stateoftheart by developing new personalised risk stratifications biomechanical foot models innovative activity and adherence profiles wearable technology systems for biomechanical and activity monitoring and personalised optimised footwear intervention products dialect will provide dcs with a comprehensive skillset capable of delivering highquality scientific and industry solutions to develop into leading innovators in the european healthcare sector who are highly employable and ready to engage and lead the next european generation of scientistsentrepreneurs to expedite progress in reducing the patient societal and economic burden of diabetic foot disease
political and community engagement trust and identity among european adolescents and emerging adults

the project will develop and validate measures on adolescents and emerging adults social cultural and political identity their sense of belongingness in different groups their participation in physical and online communities their interest in democratic participation and their trust in democratic institutions the measures will be used to explore and understand 13 and 15year olds political and community engagement in almost all countries in europe through the survey health behaviour in schoolaged children a whocollaborative study as well as emerging adults turned 18 years of age further qualitative information on adolescents and emerging adults perspectives of what is political and community engagement to them and how to they act on or communicate their perspectives on key societal issues will be collected and analysed the project will also identify formal and informal structures for youth democratic participation in a selected number of countries a key focus here will be to explore adolescents and young adults participation in communities on social media platforms to learn where and how they communicate their political and community engagement finally the project will develop policy initiatives with adolescents and emerging adults and policy makers using the cocreate dialogue forum tool including piloting of strategies in living labs marginalized groups will be given particular emphasis in the analyses to identify need for specific focus in policy development strategies
effective advancements towards uptake of pv integrated in buildings infrastructure

increase aims to contribute to a wider uptake of ipv by delivering innovations at module and system level as well as for the design operation phase new encapsulants and coatings will be developed contributing to improved aesthetics reduced glare lower environmental footprint improved behavior during fire and improved antifoiling and antisoiling behavior at system level innovations focus on integrated facade and roof concepts as well as noise barriers practical guidelines will further be delivered for bespoke infrastructure integrated projects validated with a variety of complementary infrastructure integrated pv projects elaborate testing is foreseen at module and system level in line with relevant construction related and electrical standards optimal casespecific selection of ipv size and characteristics will be supported by a multiobjective optimisation software that takes into account the shape and use of the building or infrastructure its surroundings and its energy flexibility potential and steer the asset operation as well as suggest specific user behaviour to maximise the selfconsumption to increase market acceptance a strong layer of user feedback and cocreation underpins the overall rd activities and contributes to delivering 10 complementary building and infrastructure demonstrations on 9 locations in 6 european countries crosssector interactions policy exchanges investor dialogues and countryspecific business case assessments will further direct the exploitation towards large scale market uptake
neuronal mechanisms for conscious perception

understanding the mechanisms for consciousness is arguably one of the most intriguing questions of modern neuroscience why are some visual stimuli consciously perceived whereas others remain subliminal what is the relation between conscious perception attention and working memory recent work of my lab demonstrated that weak but simple stimuli can be reported once they elicit a minimal level of activity in the frontal cortex which is related to the storage of the stimulus in working memory for these simple stimuli the visual cortex acts as a relay station that needs to pass the information to higher cortical areas however we found that the perception of more complex visual stimuli relies on a more sustained interaction between visual cortex and associative brain regions related to scene segmentation and visual attention these recent results pave the way for a genuine understanding of mechanisms for consciousness inspiring new paradigms that assess the awareness of stimuli while varying the demands on attention and working memory the present proposal will be the first to compare the neuronal fate of simple and complex stimuli that do and do not enter consciousness across most brain regions we will measure the activity of single neurons in human patients who are implanted with electrodes as part of their treatment of drugresistant epilepsy we will also use a new method that permits the recording from numerous single neurons within an entire hemisphere of a monkey and characterize neuronal activity in most regions of the cortex and subcortex we will use perturbation methods at numerous locations throughout the brain in combination with functional imaging in monkeys to measure a functional connectome and to investigate the brain regions in which activity does or does not readily lead to a reportable experience the proposed combination of experiments will provide unprecedented insight into how sensory stimuli give rise to conscious perception