Dragon09/odtu_chatbot huggingface dataset:
relativistic jets in the multimessenger era

the birth of multimessenger astronomy is unfolding in front of our eyes largely thanks to incredible observational developments the new observations challenge theory on numerous frontiers and my goal is to address some of those and to open others relativistic jets are the classical multimessenger sources typically dominating the observed signature of the objects that launch them relativistic jets even have their own gravitational waves signature jetgw that arises from the jet acceleration this signal largely ignored so far is a memory type wave that enable us to see directly the jet launching process and is probably the only way to do so detection of jetgws is extremely challenging and they may be easily missed if they are not looked for in this program i aim to achieve the understanding of these signals essential for their detection in addition i propose to explore observational implications of relativistic jets as they are manifested in binary neutron star mergers bns gammaray bursts grbs and a subpopulation of supernovae sne that harbor hidden jets and tidal disruption events tdes i will study the basic physics involved carry out large scale simulations and probe new observational results i will focus on new physics for example photodissociation of heavy nuclei during jet propagation within bns ejecta that hasnt been considered so far powerful jets appears in some tdes but not in others this makes tdes natural laboratories to pursue the major open question under which conditions are powerful jets launched although bns grbs sne and tdes appear to be very different their jets have a lot in common understanding them requires analysis of the same basic physics and application of similar numerical tools this joint study that breaks artificial conceptual barriers will be highly beneficial and fruitful
the epistemology of costly communication offline and online

in our digital era characterised by easy access to both information and misinformation understanding the mechanisms that encourage truthful communication is more crucial than ever despite the social and ethical importance of these issues however we lack a unified framework to systematically investigate the social incentives that motivate speakers to communicate truthfully costx will inaugurate a novel interdisciplinary empiricallyminded approach to studying communicative norms the projects overarching goal is to develop a new methodology grounded in costly signalling theory to study how norms and reputation underlie truthful communication offline and online adopting this new lens costx will radically change our understanding of a diversity of phenomena relating to truthfulness i the nature and epistemic function of communicative norms ii deniability and indirectness in speech iii testimonial transmission of knowledge and iv online communication it will inaugurate a new field of study digital infrastructure epistemology which investigates how misinformation spreads by attending to how online platforms alter the reputational infrastructure that motivates speakers to be truthfulmethodologically costx will bring rigorous analytic thought into dialogue with empirical research theoretical assumptions will be tested empirically and theorybuilding will profit from interdisciplinary crosspollination from linguistics biology game theory epistemology and psychology it will be of high scientific value to all disciplines investigating or building on human communication and its norms its findings on online communications will have practical uses establishing philosophical foundations to better understand and tackle the spread of fake news thus bolstering support for democratic institutions which rely on a healthy information environment to function properly
stardance the noncanonical evolution of stars in clusters

thanks to their ubiquity brightness and the fact that they are made of stars with similar properties star clusters have been used as astrophysical laboratories or test particles in an impressive range of research domains however we still do not understand fundamental details of their formation and evolution in spite of recent technological progress a list of unsolved problems and apparently isolated mysteries has been accumulating over time some standing since decadesamong them the existence of multiple stellar populations in globular clusters with different chemistry has challenged generations of researchers they are not the result of classical galactic chemical evolution mostly mediated by supernovae and they jeopardize the use of clusters as simple stellar population templates for extragalactic studiesgiven the mounting problems faced by the most favored scenarios to explain multiple populations i think it is now time to revisit the foundations of our current thinking new results by my team and by others show that i the peculiarities in the chemistry of multiple populations are not limited to the oldest globular clusters ii they can be transient in the evolution of individual cluster stars and most importantly iii binary interactions and fast stellar rotation cannot be neglected in the study of star clusters and do have the capability to produce the observed chemistrywith stardance i will test a very different scenario based on a new hypothesis that multiple stellar populations and five other noncanonical stellar populations extreme horizontal branch stars and hot subdwarfs extended main sequence turnoffs red stragglers and subsubgiants lithium rich stars and blue stragglers are caused by the interplay between stellar rotation and binary interactions that are greatly enhanced in the special environment of star cluster with spectacular results
soteriological itineraries in the ancient mediterranean world

mappingsalvation aims at establishing a novel methodology for the study of salvation experiences and theories structured around a newly developed epistemic model that allows for a thorough investigation of salvation itineraries across multiple cultural contexts the geographicalhistorical framework of reference for this research is the mediterranean basin in the early roman imperial age a world animated by a strong pervasive desire for salvation which permeated most areas of human experience philosophical reflection religious cults and beliefs political life and ideology ritual and divinatory practicethis project relies on the groundbreaking hypothesis that only by conceiving the ancient mediterranean world as a wide intricatenetwork of salvation itineraries can we fully exploit the heuristic potential of the category of salvation understand the profoundphilosophicalreligious dynamics of the first centuries ad and even discover unexpected similarities between this age and ourcontemporary world where the needs to save human lives animal species and our planet are all the more urgent and intenseby analysing the greek and latin works of two apparently distant thinkers seneca the younger and clement of alexandria mappingsalvation will attain a twofold aim first to validate empirically a new analytical model and taxonomical system for the examination and categorisation of salvation itineraries second to inaugurate a wideranging discussion around the concept of salvation and a cooperation among different scholars and fields of expertise that have worked separately until today if successful mappingsalvation will revolutionise the way in which we look at salvation in antiquity and beyond and will establish a shared conceptual apparatus and common epistemic standards for its study
optimizing production and logistic resources in the timecritical bio production industries in europe

the clarus project aims to connect the sustainable paradigm in the food industry and aibased applications with the goal of developing a platform with high communications and processing capabilities as well as the use of standardized open protocols and data models that will allow resource consumption assessment and traceability for food industry processesthe project will be submitted under the call hecl4digitalemerging0109 ai data and robotics for the green deal and will target the nonrobotic outcome currently two pilots have been selected for validating the clarus solution the first pilot focuses on the production of the frozen food where energy and water consumption can be reduced using ai and data technologies the other pilot focuses on the meat byproduct production where the aim is to reduce the energy and maintain the quality of the products by optimizing the logistics of the byproducts arrival clarus ambitions include not only contributing to resource and logistic optimization methods through the two pilot solutions but also making a more general contribution through the creation of a green deal index gdi
production of an innovative millifluidic device for testing of new probiotics

over the last decades the gut intestinal microflora and other microbial communities present in our body raised a strong interest in the health research domain as it was discovered their possible relation to the pathophysiology of major organs and systems gut epithelial cells together with our resident microbiota are involved in the modulation of the host immune system and represent the first line of adsorption of drugs and nutraceuticals in parallel to microbiota studies a great effort has been devoted to assess the role of the probiotics live microorganisms that administered in adequate amounts are able to confer a benefit to the host health probiotics are currently widely used in the preventiontreatment of many diseases one critical point that is still an issue in the characterisation of new potential probiotics is the difficulty in mimicking with high reliability the gut microenvironment condition using animal models or the current in vitro tools poorly representative of the real in vivo situation this gap motivates the need for the development of alternative research tools such as the fluidic devices to study the mechanisms at play in human gut microenvironment and contribute to the success rate of expensive risky and timeconsuming preclinical and clinical trials in this frame our prometeo project aims to perform the technical and commercial feasibility of an integrated probioticgut epitheliumimmune system millifluidic platform based on a patented organonachip technological device providing the basis for a new generation of innovative solutions for probioticsdrug development prometeo will be run by a consortium between politecnico di milano and aatadvanced analytical technologies a forefront sme specialized in promoting innovation in the probiotic sector thus combining a solid technological expertise and an indepth knowledge of the market
sparc sustainable parasite control in grazing ruminants

ruminant farming is critically important in maintaining the viability of rural communities and ensuring food security because grazing ruminants are permanently exposed to helminth parasites efficient worm control is a requirement to guarantee their health welfare and productivity worm control is largely based on preventive use of anthelmintic drugs but excessive use of anthelmintics has led to anthelmintic resistance which has become a global threat for effective parasite control to mitigate anthelmintic resistance in ruminants sustainable worm control swc strategies should be adoptedthe sparc community of practice of farmers farm advisors and veterinarians will identify needs practices barriers and drivers for adoption of swc practices develop a list of good practices for swc in different production systems and regions and demonstrate them on pilot farms national and international stakeholder networks will share swc practices among farmers across borders and production systems beef and dairy cattle meet and milk sheep and goats dissemination of experiences and results will be facilitated by a knowledge exchange platform on the sparc website hosting testimonies case studies videos practice abstracts and decision support tools available in local languages sparc activities and results will be communicated on social media and in professional journals overall sparc will initiate a lasting europeanwide multiactor community that develops solutions together to curb anthelmintic resistance aiding in the green transition of european agriculture
understanding the new oxidative paradigm of biomass waste upcycling

as the eu is committed to becoming the worlds first climateneutral continent fossil fuels need to be replaced by sustainable alternatives a potential alternative is the upcycling of lignocellulosic biomass to biofuels however the costefficient generation of biofuel from cellulose is considerably hindered by the recalcitrance of the cellulose biopolymer in 2010 the discovery of a new family of copperdependent metalloenzymes called lytic polysaccharide monooxygenases lpmos spurred great hopes as lpmos were shown to significantly boost the degradation of cellulose and other polysaccharidestoday eight families of lpmos have been classified with remarkably diverse substrate specificities and regioselectivities furthermore the metal active sites are in rather different surroundings despite combined efforts from experimental and theoretical sides the reaction mechanism of lpmos has remained elusive the here proposed lyticpol project suggests that previous theoretical studies lacked general conclusions because they i considered too few lpmo families and ii employed insufficient theoretical methods for the enzyme environmentthe lyticpol project aims at elucidating the reaction mechanism of lpmos by using a novel theoretical method on a large set of representative lpmo structures from knowing the mechanism the reaction conditions of lpmos can be finetuned and the full industrial potential can be reached this is expected to have substantial economic and social impact hence the results of the lyticpol project will be communicated not only to scientific experts but also to the general public the project will be carried out by dr erna k wieduwilt ekw under the supervision of prof erik d hedegrd at the university of southern denmark the project itself and the training of ekw will contribute decisively to her career goal of becoming an innovative and independent researcher in the field of theoretical bioinorganic chemistry
curing ovarian cancer through autoantibodybased therapy

ovarian cancer oc is a malignant tumor with poor prognosis and limited treatment options responsible for 44 of cancerrelated mortality in women there is an urgent need for innovative therapeutic approaches for oc antibody drug conjugates adcs represent one of the most promising therapeutic approaches but their efficacy has been hindered by identification of suitable tumorassociated antigens for example adcs targeting muc16 the best diagnostic marker for oc have thus far failed in clinical trials due to shedding of muc16 from the tumor our breakthrough lies in the identification and characterization of a muc16specific autoantibody clone 2b5 which specifically targets the nonshed and highly conserved epitope of muc16 that stays associated with the tumor this consequently dramatically increases the efficacy of the cytotoxic payload delivery to the tumor and overcomes limitations of similar adcs that have failed in the past by directly and selectively targeting muc16 on oc while sparing healthy tissues our adc has the potential to revolutionize oc therapy by finally offering a precise and effective adc cancer treatment thus for this poc we aim to demonstrate the effectivity of our 2b5based adc as a leading candidate for oc therapy in humans in order to increase its therapeutic and commercial potential the 2b5based adc will be developed further to identify the most suitable payload as well as to validate its tumor killing efficacy in preclinical animal models which will be developed in frame of this project by the end of this poc we aim to be ready to develop our 2b5adc to human grade towards phase 1 clinical trials simultaneously we will define the innovation commercial feasibility and business model and will validate the business opportunities and gotomarket strategies with relevant stakeholders furthermore we have already initiated the process of patenting our innovation and aim to finalize it during the poc
investigating the effect of composite microstructure on wave propagation characteristics and development of an ultrasonicdatadriven computational framework for composites damage mode identification

the eu is a world leader in the transport industry especially aviation it is predicted that the number of flights in europe will increase to 13 million in 2028 26 times more than those in 2020 this remarkable number of flights will place airworthiness at the heart of technology development which makes regular inspection timely diagnosis of technical problems and optimising design and construction of aircraft components of paramount importance superior mechanical properties especially a high strengthtoweight ratio make composites an ideal candidate for the construction of aircraft parts however detection and evaluation to maintain composite structural integrity are particularly challenging since they are inhomogeneous and anisotropic although ultrasonic guided waves ugws have exhibited strong potential for detecting damage signatures in composites nucleation of defects and damage propagation occurring within numerous locations at several length scales make it difficult to track all the damage sites and mechanisms which is vital for improving composites design and production thus understanding ugw interaction with complex anisotropic structures of composites that can be accessed considering composite microstructure is a fundamental issue that remains unresolved microsonic will bring a fellow with expertise in micromechanics and damage modelling together with the host institution carrying leading knowhow in ugw interaction modelling to investigate the effect of composite microstructure ie fiber size volume fraction and distribution and microdamage on wave propagation and establish the next generation of ultrasonic usdatadriven computational frameworks developed based on the micromechanics outputs for composites damage mode identification microsonic will provide safer flights by establishing a robust tool for online monitoring of aircrafts structural health state and boost europe to the forefront of the inspection and maintenance market
mri analysis tool for early detection of dementia

worldwide due to population ageing there will be 75 million patients with alzheimers disease by 2030 alzheimers is a disease described by accelerated brain ageing which leads to decline in both memory and cognitive skills thus affecting everyday activities of those suffering on average over 60 of patients do not receive a diagnosis and average cost of misdiagnosis is estimated to be over 2k existing screening and early diagnostics methods lack speed and accuracy are not automated enough and detect only already existing symptoms when it is late for prevention at neurosalience we develop a software for assessing brain ageing for early detection of alzheimers disease from lowresolution mri and ct scans measuring subjects brain age and extracting important features for making a prediction are used to assess the risk of alzheimers disease the tool determines whether patient has alzheimers along with its stage and type of dementia we aim at supplying healthcare providers with a more accurate cheaper and faster early diagnostic tool for alzheimers disease the tool allows decreasing patientrelated costs and improving the quality of life of patients the tool is first in the world to be capable of processing even lowresolution mri data and providing interpretable results over whole brain with the support of the women techeu programme we will boost the market readiness of the neurosalience tool by developing the project both from business and regulatory perspectives for this purpose we plan to develop a pricing model for the tool improve deep learning models used in the product and prepare all the documentation along with quality management system required for regulatory approval we would benefit from the women techeu services of mentoring and coaching on how to support and run investor relationships as we plan to set up partnerships with hospitals we would also benefit from advice on running such partnerships in the healthcare
transformative climate resilience by naturebased solutions in the continental biogeographical region

it is demonstrated that nature based solutions nbs efficiently and effectively contribute to climate adaptation however nbs need to be adapted locally and to be coherently chosen in order to assure sustainability and no side effects to achieve this arcadia will mobilise 8 european regions and communities from italy croatia austria denmark sweden bulgaria romania slovenia to accelerate nbs adoption and assist them in accessing uptodate evidencebased actionable knowledge guidance knowledgeintense tools and services mutual learning and networking opportunities the project will foster enabling conditions to accelerate regeneration using nbs by analysing individual and socially determined perceptions of risks and solutions and experimentally designing incentives and behavioural nudges fostering social acceptance and community actionsin arcadia the definition of regional ambitions and of methodologies and approaches codeveloped at consortium level will be followed by the implementation of 15 coinnovation labs with the engagement of the interested communities and societal partners the learning across policy areas will be exploited to upscale and deploy at large scale the solutions in the regions developing robust policy and economic tools regulations funding schemes business models investment tools strategic objectives of the proposal are1 codesign regional strategies to accelerate transformative adaptation building upon and mainstreaming innovative actionable nbs with demonstrated feasibility effectiveness and social value2 assist and empower communities public administrations and businesses3 stimulate collaborative knowledge building and transfer developing capacities and capabilities4 promote coherence and exploit synergies value and production chains and public and private spheres of business innovation5 advance eu research innovation agenda on nbs and eu mission adaptation