Dragon09/odtu_chatbot huggingface dataset:
deep learning derived mechanical biomarkers for cancer therapy prediction

in the fight against cancer it is well recognized that tumors are highly heterogeneous and they might differ considerably not only between tumors types but also among tumors of the same type or even for the same tumor during progression as a result the efficacy of standard cancer therapies varies and while some patients respond to a particular treatment other patients do not gain any benefit consequently crucial in cancer therapy is the prediction of a patients response to treatment failure of standard therapies has led to the introduction of a new era of personalized patientspecific treatments which are based on the identification of biomarkers that characterize the state of a particular tumor many solid tumors eg breast cancers and sarcomas stiffen as they grow in a hosts normal tissue tumor stiffening is a known factor leading to compromised efficacy of therapeutics recently it has been demonstrated by our team and coworkers that repurposing of common drugs with antifibrotic properties known as mechanotherapeutics target tumor stiffness and enhance therapy here we aim to harness the power of deep learning dl methods in order to develop a robust biomarker based on ultrasound shear wave elastography swe this biomarker will aim to i predict patients response to treatment separating responders and nonresponders and ii monitor treatment outcomes in the case of strategies that target tumor stiffness ie mechanotherapeutics the dl algorithms will be applied to a large set of existing preclinical data and to additional new data a proof of concept clinical study on sarcoma patients will accommodate the clinical translation of the biomarker furthermore we propose to develop a software product to be used as a commercial tool for the measurement of the dlderived swe biomarker a planned market research will highlight the best options for commercialization
a grant to support the mission director and the annual innovation summit of the urban transitions mission under mission innovation

a grant to support the mission director for the urban transitions mission under mission innovation coled by the european commission dg research and innovation rtd the global covenant of mayors for climate and energy gcom and joint programming initiative urban europe jpi ue this grant covers the resources required to appoint the director for an initial twoyear period including overhead costs as well as travel and external event engagements it also contains a contribution towards conceptualization development and execution of the planned annual innovation summit under the urban transitions mission a gathering of clean energy and netzero leaders across national governments and the european commission cities and local governments businesses academia and civil society
worlds first diagnostic test that can detect all bacterial species in a single assay

every year bacterial infections cause 20 of human deaths these deaths can be avoided only if the patients are administered correct medical treatment without any delays today the diagnostic tests used to detect and identify bacteria are too slow or not comprehensive enough often doctors have no other option but to administer treatment through antibiotics based on educated guesswork which can lead to medical complications in addition to increased patient care costs to address these issues inbiome is developing a costeffective diagnostic test called molecular culture which detects and identifies all bacterial species with 100 accuracy and delivers results within 4 hours during the eic project inbiome will perform an implementation trial of molecular culture in a live hospital setting optimizing the interface for hospital workflows clinical validation of additional sample types adding antimicrobial resistance testing in the workflow and expanding commercial skills
orchid organic reactions through carbon addition to h2 on interstellar dust grains

the recent progress in astrochemical studies of the molecular makeup of the interstellar medium ism has revolutionized our understanding of the early phases of star and planet formation a significant gap however still exists and that involves the role of molecular hydrogen h2the most abundant molecule in the universein interstellar ice chemistry orchid aims to fill this gap by investigating the impact of h2 on the formation and evolution of complex organic molecules icoms in the ism given the lack of existing literature detailing solidstate reaction pathways incorporating h2 orchid hypothesizes that h2 reactions with carbon atoms is instrumental in unexplored chemical pathways for icoms formation to achieve its objectives orchid uses stateoftheart experimental setups to produce quantitative data that aligns with the latest observations of interstellar ices from the james webb space telescope jwst and gasphase observations from radiotelescopes like the atacama large millimetersubmillimeter array alma specifically the project 1 explores icoms formation through previously overlooked pathways involving h2 completing and extending reaction networks in the ism 2 generates accurate parameters for astrochemical models facilitating simulations that match observations of star and planetforming regions 3 investigates the conditions under which icoms are released into the gas phase especially at temperatures where thermal desorption is not feasible in the ism the insights and data generated by orchid will serve as a robust foundation for interpreting ongoing and future astronomical observations moreover the project will enrich existing gasgrain kinetic models effectively bridging the graingas gap and thereby advancing our understanding of how chemical processes in the ism influence the composition of celestial bodies in star and planetforming regions
how effective are illiberal strategies of citizen manipulation

the widespread popular support for illiberal leaders seeking to subvert democracy is one of the more puzzling and concerning developments in the 21st century from putin through orbn to erdogan illiberal leaders invest large resources into propaganda organize grandiose displays of support and promote hostile rumours about their enemies but do such attempts at manipulation shape citizens support and acceptance of the illiberal leader prior research yields conflicting expectations on the one hand research in psychology and political behaviour identified a plethora of cognitive biases which undermine citizens ability to punish leaders for their mistakes or wrongdoings on the other hand recent evidence shows that people are difficult to persuade making it unlikely that propaganda could change the minds of citizens who are critical of an illiberal leader to adjudicate between these accounts this project will a develop a novel framework for studying the effects of illiberal manipulation strategies and will examine the effects of multiple manipulation attempts such as b hostile rhetoric c political misinformation campaigns and d populist appeals to fairness intuitions the project builds on an interdisciplinary framework bridging insights from comparative politics and psychological science and will employ a diverse set of methodological tools from multiple survey experiments vignette conjoint and cultural transmission designs as well as quantitative text analysis original comparative survey data from hungary the us and denmark will be used to compare citizens susceptibility to manipulation under different political environments the project contributes to the european commissions priority of a new push for european democracy by informing prodemocracy stakeholders and citizens on the perils of illiberal citizen manipulation
new frontiers in optimal adaptivity

the ultimate goal of any numerical method is to achieve maximal accuracy with minimal computational cost this is also the driving motivation behind adaptive mesh refinement algorithms to approximate partial differential equations pdespdes are the foundation of almost every simulation in computational physics from classical mechanics to geophysics astrophysics hydrodynamics and micromagnetism and even in computational finance and machine learningwithout adaptive mesh refinement such simulations fail to reach significant accuracy even on the strongest computers before running out of memory or timethe goal of adaptivity is to achieve a mathematically guaranteed optimal accuracy vs work ratio for such problemshowever adaptive mesh refinement for timedependent pdes is mathematically not understood and no optimal adaptive algorithms for such problems are known the reason is that several key ideas from elliptic pdes do not work in the nonstationary setting and the established theory breaks downthis erc project aims to overcome these longstanding open problems by developing and analyzing provably optimal adaptive mesh refinement algorithms for timedependent problems with relevant applications in computational physics this will be achieved by exploiting a new mathematical insight that for the first time in the history of mesh refinement opens a viable path to understand adaptive algorithms for timedependent problems the approaches bridge several mathematical disciplines such as finite element analysis matrix theory nonlinear pdes and error estimation thus breaking new ground in the mathematics and application of computational pdes
geomicrobiology of feiibearing minerals and nitratereducing ironoxidizing microbial cultures

nitratereducing ironoxidizing nrfeox microorganisms which couple feii oxidation to nitrate reduction using organic matter or carbon dioxide as a carbon source play an essential role on a global scale in three of the most important biogeochemical cycles iron carbon and nitrogen from an ecological point of view nrfeox microorganisms are key players in several processes such as the biological oxidation of fe in anoxic and dark environments the reduction of atmospheric carbon dioxide and the removal of nitrate from polluted groundwater aquifersthe aim of this project is to analyze the ability of nrfeox communities to thrive using feiibearing minerals as an energy source the ecological consequences of the mineral transformation and to explore the mechanism of microorganismmineral interaction which is crucial to fully understand their role in natural environments first culture techniques will be applied to identify feii bearing minerals that can be oxidized by nrfeox communities subsequently molecular biology techniques will be applied to analyze the structure and distribution of nrfeox communities when they grow using minerals as an energy source and to determine the main actors in the process finally analytical microscopy techniques will be used to study at the nanometer scale the interaction between specific microorganisms with the mineral surface for this purpose stateoftheart techniques such as confocal raman microscopy scanning electron microscopyenergy dispersive xray spectroscopy and xray photoemission electron microscopy will be correlated with fluorescence in situ hybridization and fluorescence microscopythe data obtained in the minox project could not only be applied to biotechnological processes and integrated into predictive models for the management of nitratecontaminated waters but will also unveil a totally unknown area of geomicrobiology the transformation of feii minerals by nrfeox microorganisms
new approach to innovative technologies in manufacturing

at the dawn of 21st century the importance of economy being up to date with the latest scientific developments such as industry 40 is more evident than ever before recent global situation has proven that in order for the principles of i40 to be successfully implemented the industry must cooperate closely with universities and authorities in poland this cooperation is still insufficient and to solve this problem gdask tech teams up with kth stockholm tu berlin and ntu athens the overall objective of the neptun project is to raise the gdask tech level of excellence in the area of additive manufacturing accompanied by cloud computing and control virtual reality modelling and simulation technology the project will allow gdask tech to become a leading entity in the research and innovation not only on a regional but on a national level making it an efficient partner in developing industry 40 in poland the partners experience and expertise with research and innovation activities in such fields as applying dmlssml sls and fdm for prototyping with incorporating the process and parameter optimization and control of 3d printed materials for functional use modelling robotic cells in vr environment or applying evolutionary algorithms in manufacturing will allow gdask tech to expand its expertise and to engage in rdi activities on a whole new level an important aspect of the project is a work package connected with exploratory research project related to fabrication and design of new mechanical metamaterials artificial structures whose mechanical properties are defined not only by their composition but also by their structure other wps will boost the development of industry 40 on the regional and national level by forming neptun cluster of excellence neptun will raise the attractiveness of the profile and research potential of all the partners it will build a network of scientific contacts aimed at future research projects and publications
saving patients from severe heart failure

the icoms flowmaker is the first intracardiac assist device that overcomes all shortcomings of current and under development devices and restores patients quality of life its design perfectly fits all the needs of patients suffering from severe heart failure implanted inside the left ventricle and synchronized with natural heartbeat it assists the heart to push blood in a physiological way the very low electrical consumption allows for wireless functioning with no driveline crossing the skin the risk of infection is suppressed without bypass to aorta and thanks to its pulsatile mode the risk of bleeding is very low the icoms flowmaker addresses the market of severe heart failure where 95 of patients are left without any solution the aim of the project is to conduct the clinical trials to enter the eu market in 2026 then the us market allowing to finally achieve eu sovereignty in severe heart failure treatment
the ancients affective perception of the past shaping a philosophical framework for archeology

this interdisciplinary research project aims to construct a philosophical framework for understanding how ancient civilizations particularly the residents of pompeii emotionally engaged with their past through material culture building upon theories from situated affectivity cognitive science philosophy of emotions archaeology philology history roman law and nostalgia studies the project will use pompeii as its main case study specifically it will focus on the citys history between two catastrophesthe earthquake of 62 ad and the vesuvius eruption of 79 ad utilizing the principles of upcycling affective scripts and niche construction theory the project explores how material culture influenced human cognition and emotions through a comprehensive examination of literature and historical texts the research aims to identify and reconstruct affective scripts supported by material culture offering new insights into the emotional experiences of ancient peoples this project will not only refine current archaeological conceptualizations but also extend the application of situated affectivity theories in innovative ways as an earlycareer researcher i see this project as the next evolutionary step in my scholarly journey undertaking this research under the supervision of prof haug at kiel university will enable me to deepen my expertise in archaeology and extend the boundaries of situated affectivity beyond technical expertise this fellowship with prof haug at kiel university will provide comprehensive training in soft skills like scientific communication grant writing and interdisciplinary collaboration these skills will not only augment my research capabilities but also enhance my employability in both academia and public sector especially museums and the italian ministry of culture
material and digital traceability for the certification of critical raw materials

maditraces main goal is to enlarge and integrate the portfolio of technological solutions reinforcing the reliability of critical raw material crm tracking and the transparency of complex supply chains the project aims to develop and test independent digital and geobased approaches for crm traceability and to integrate them with a generic certification scheme for crms throughout mineral supply chains from the mine to the manufactured and recycled products the project intends to increase the trl of experimental or largely untested methods in both domains digital and material sciences a special attention will be payed to the complexity of mineral supply chains with points of material aggregation and of transformation processing refining including circular economy recycling this methodology will enable downstream industrials to prove the reliability of their sustainability claims complying with regulation in force notably eu battery regulation german supply chain act and anticipating implementation of regulation to come eu directive on corporate sustainability due diligence maditraces fundament is a strong stakeholder process wp1 with upstream and downstream industrials from mining to manufacturing industry and large networks involved via the consortia eitrm and clusters ismc participating in the project continuous interaction with this industrial and policyoriented stakeholder community on the traceability technology wp2 and wp3 and the certification schemes wp4 developed in the project will ensure to stay in line with industrial needs and expectations with respect to regulatory compliance it will also facilitate implementation and exploitation wp5 of the project outcomes
networking food plant imports in roman italy

the emergence of the roman empire marked a series of significant political and socioeconomic changes across modernday italy as well as across a very large part of modernday europe among these the establishment of a new transport network and the development of trade and commerce that this facilitated was one of the most important and lasting changes netfoodit aims at using imported food plants for the study of roman transport and movement and the socioeconomic dynamics that this established within the core of the roman empire and its broader surroundings that is across modernday italy in doing so netfoodit will shed new light into the relation between mobility commerce and the introduction of new tastes in roman italy netfoodit will develop a geodatabase of roman food imports assemblages and study their social access and rarityregularity in combination with the roman transport network the project will next investigate the centrality of the sites with these imports their character as consumption or redistribution centres and will reconstruct the routes for the distribution of these food plants this will provide important insights into roman commerce economy and the extension and acquisition of new tastes as rome expanded and developed contacts with other ancient cultures in order to do so a combination of novel techniques which include social network analysis site rarity index calculations spatial network analysis and spatial statistics will be employed in conjunction for the first time for roman italy these methods and the training provided during their implementation by a team of leading international researchers will enhance the candidates profile with cuttingedge techniques that will situate her at the forefront of research and boost her career
the widefield spectroscopic telescope

we propose a conceptual design study for a 12metre widefield spectroscopic survey telescope wst with simultaneous operation of a large fieldofview 3 sq degree highmultiplex 20000 multiobject spectrograph mos and a giant 3x3 arcmin integral field spectrograph ifs in scientific capability these specifications place wst far ahead of existing and planned facilities in only 5 years of operation the mos would target 250 million galaxies and 25 million stars at low spectral resolution plus 2 million stars at high resolution without need for preimaged targets the ifs would deliver 4 billion spectra offering many serendipitous discoveries given the current investment in deep imaging surveys and noting the diagnostic power of spectroscopy wst will fill a crucial gap in astronomical capability and work in synergy with future ground and spacebased facilities we show how it can address outstanding scientific questions in the areas of cosmology galaxy assembly evolution and enrichment including our own milky way the origin of stars and planets and time domain and multimessenger astrophysics wsts uniquely rich dataset may yield unforeseen discoveries in many of these areas the study will deliver telescope and instrument designs cost estimates an updated science white paper and survey plan concept studies for data management and a facility operation concept the telescope and instruments will be designed as an integrated system and will mostly use existing technology with the aim to minimise the carbon footprint and environmental impact we will propose wst as the next eso project after completion of the 39metre elt our consortium includes institutes from australia which has a strategic partnership with eso and aims to apply shortly for full membership together with eso and institutes in 9 european countries our team has the necessary technical and scientific expertise and brings 70 years of inkind effort to the proposed study
intersectional faces of labor organization solidarity and mobilizations in logistics in europe

the proposed action intersectional faces of labor organization solidarity and mobilizations in logistics in europe infala aims to systematically examine the forms of solidarity agency and labor organization of workers from the middle east and north africa mena region who have become increasingly present in european labor markets and in some countries are particularly visible in logistics with few efforts engaging with labor on intersectional terms and especially those from the mena region who constitute the majority of those migrating to the eu infala investigates two contrasting cases among the largest economies in europe of italy and germany with three objectives in mind 1develop an analytical framework to analyze intersectionality solidarity and labors agency and establish the contextual foundation by mapping trajectories of mena migration to italy and germany access to labor markets visa regimes and bilateral agreements2conduct a threelayered interdisciplinary case analysis of the macronational of italy and germany mesosectoral being logistics and microworker levels3compare these two case studies based on analytical framework to derive larger insights regarding transnational solidarity and larger labor movement the msca postdoc fellowship would be a crucial step for my career development allowing to build on my knowledge in political economy to dive into the broad logistics sector to investigate the processes of intersectional and transnational solidarity building that innovate on or depart from more traditional classbased labor organizing in europe it would be hosted by the scuola normale superiore sns in florence which hosts the internationallyrenowned centre on social movement studies cosmos under the supervision of professor guglielmo meardi who has a longstanding expertise in comparative research on industrial relations labor migration and labor movements