Dragon09/odtu_chatbot huggingface dataset:
illiberal administrative behaviour exploring the implementation of illiberal policies and strategies for prevention

democracy is at risk also from the inside today some civil servants are mandated to implement illiberal policies defined as those including antiplural discouraging dissent and promoting homogeneity or antiinstitutional values rejecting separation or supervision of power civil servants who oppose these policies face severe criticism and replacement conversely others may behave illiberally and comply with the implementation request since public bureaucracy is essential for effective governance the question of whether civil servants will implement illiberal policies thereby displaying illiberal administrative behaviour arises yet it is surprising how little we know about this behaviour why it occurs and how it can be preventedto investigate these questions this project 1 defines and elaborates a conceptual map of illiberal administrative behaviour and empirically examines civil servants positions on it 2 identifies the determinants of illiberal administrative behaviour 3 examines how civil servants can align with liberal democratic values to reduce their likelihood of implementing illiberal policies the empirical analysis focuses on 10 countries from 5 administrative traditions and implements an integrative multimethod approach combining panel surveys with different measurement strategies and experimentsthe project breaks new ground in the study of illiberalism in public administration and offers fresh insights on the current crisis of liberal democracy theoretically it conceptualizes illiberal administrative behaviour elucidating the conceptual underpinnings of this phenomenon empirically it develops measurement tools for assessing illiberal administrative behaviour among civil servants examines its primary determinants and explores innovative mechanisms to counteract these processes these contributions are developed by adopting an innovative interdisciplinary strategy
hybrid trajectories of transnational islamism

the uprisings that broke out on the southern shores of the mediterranean in 2011 and the waves of migration that followed have shed light on the resurgence of islamist movements in north africa and on a renewed presence of islamic communities in the western world on the one hand media policymakers and national intelligence services have increasingly focused on the integration of muslim communities in host countries however these analyses have been limited to the housekeeping relations between migrant communities and the host states and have not explored the transformative dynamics of islamist movements when they go transnational on the other hand while studies on islamic activism have effectively highlighted the role of domestic and international factors in transforming the organisation and ideology of islamist actors the literature has barely focused on the transnational dimension as an analytical space of enquiry in itself indeed scholarly work on the topic has not systematically investigated the impact of transnationalisation dynamics on the ideological organisational and sociopolitical dimensions of movements this gap led to simplistic analyses based on a monolithic interpretation of islamist movements relying on the dichotomy moderationradicalisation hybris aims to overcome this gap by examining the hybrid trajectories of transnational islamism in a systematic way and from a crosscountry perspective the project will break new ground in the field by mapping the different trajectories of ennahda and the islamic salvation front fis starting from the ties and networks that activists and organisations belonging to the two movements have created between geographically distant locations it will do so by analysing two intertwined dimensions of the process of transnationalisation digital activism and relocalisation dynamics taking islamist movements and their transnational expansion in the european and north american contexts as case studies
porous networks for gas sensing

air pollution is one of the most pressing environmental challenges worldwide while outdoor air pollution appears often in the media the effects of indoor air pollution are not to be underestimated since the average person spends about 22 h per day indoors many chemicals that decrease the quality of indoor air are emitted by carpets paints furniture etc the majority of these pollutants are volatile organic compounds vocs since vocs can cause not only discomfort but also debilitating or even fatal conditions it is desirable to measure voc concentrations with high spatial and temporal resolution via lowcost but reliable miniature sensors however selectively measuring harmful vocs is particularly challenging because of the low concentration of the analyte and the multitude of interfering compounds present in indoor air currently available miniature sensors eg metal oxide semiconductor sensors typically cannot distinguish a voc of interest from for instance an air freshener sennet will develop novel sensors for the selective detection of priority vocs based on leveraging the adsorption properties of tuneable porous materials namely metalorganic frameworks mofs and zeolites to do so we will bridge the gap between two fields namely porous crystalline materials and sensor technology that have thus far been separated by traditional subject boundaries sennet is the first training network that will tackle this challenge and will do so by combining expertise in chemistry physics materials engineering and sensors a coordinated effort by 9 beneficiaries and 7 associated partner organizations from 8 countries guarantees a paneuropean approach in a multienvironment context universities research centres smes and large companies the proposed followthechallenge strategy ensures that young researchers are exposed to a variety of research environments and get involved in each step of the materials sensors value chain
shore empower students as the agents of change

shore will be focusing on engaging mobilizing students teachers and schools to implement the mission ocean objectives to increase ocean literacy with the help of community activities cooperation projects shore project will last 36 months and cover five different regional areas baltic black mediterranean sea danube rhine river area with its 14 consortium partners it will set up country hubs to offer guidance for the educators and schools on blue curricula develop and implement their projects and use open schooling methodologies contry hubs will also promote community activities such as exhibitions workshops training seminars and meetntalks to increase the awareness of ocean literacy among the society shore will provide grants to 100 schools through three open call periods for proposals to support blue projects for a maximum amount of up to 10000 euro per grant educational materials and trainings for educators will be available during th eprojec to increase their knowledge about sustainable and blue education a digital platform will be setup to monitor school projects and provide a virtual learning environment system including rewards and badges in addition at the end of each school period a public voting session will be held to raise awareness engagement create a wider audience and select the best school project which will receive the ocean ambassadorliterate of the year award an ocean literacy action center will be established within the ytu to coordinate public activities and bring researchers and public together to enhance ocean literacy during the project and thereafter
volatile element cycles on venus implications for the evolution of venus greenhousedominated atmosphere

venus is similar to earth in terms of density size and composition yet both bodies evolved so dramatically different that venus now has an uninhabitable runaway greenhouse atmosphere in contrast to earth s favourable habitable conditions despite alarming parallels with co2driven global warming on earth the origin and evolution of venus runaway greenhouse atmosphere remains poorly understood problematically current models fail to incorporate the important effects of volcanic degassing and atmospheresurface interaction throughout venus history due to venus co2rich atmosphere surface pressures are 90 times greater than on earth volcanoes on venus will degas under very different conditions yielding different volcanic gas compositions and gas fluxes to the atmosphere constraints on volatility and the contribution of magmatic volatiles to the composition of venus atmosphere are pivotal for understanding the extent and timing of volcanic activity on venus especially in light of upcoming venus exploration missions interaction between venus atmosphere volcanic gasses and surface likely plays a key role in determining volatile fluxes but is poorly understood at conditions relevant for venus surface the critical lack of such challenging experiments precludes a detailed assessment of the venusian volatile cycle and atmospheric evolutioni will quantify the past and current interiortoatmosphere volatile element flux on venus in a highly multidisciplinary approach i will perform 1 pioneering high pt experiments mimicking magma degassing on venus and atmospheregasrock interactions 2 using stateoftheart in situ analyses of gas speciation and reaction rates and 3 integrate these results in numerical models to obtain quantitative volatile fluxes for venus this work allows for rigorous reassessment of venus interior and atmospheric evolution and will provide a solid framework for future exploration of venus
share a remote tool for automated speech and language language assessment of children and personalised interventions

speech and language development is one of the most critical developmental phases in early childhood children with poor vocabulary skills at age 5 were four times more likely to have reading difficulties three times as likely to have mental health problems and twice as likely to be unemployed when they reached adulthood yet its one of the most overlooked industries in terms of innovation the way speech and language development is managed by parents teachers and healthcare providers has not changed in decadesthere is an overreliance on the clinical speech and language therapists as the only means to get an assessment of a childs speech and language skills the result of this is children sitting on waiting lists or having early signs of delays missed all resulting in missing out on reaching critical speech and language developmental milestoneswe are developing share a radical data driven and digitallydelivered solution to address the problems in understanding childrens speech and language development delivering accurate inhome assessment of speech skills is the key to disrupting this industry empowering the other stakeholders in this story to understand when a childs speech skills are on track and when they are not our goal is to reduce the over reliance on costly face to face therapy by developing solutions that dont just replicate existing practice but are developed around data and evidence and reflect the abilities and lifestyles of families this is a relatively new market segment that crosses several markets and stakeholders across speech therapy digital health and the emerging new mom economy we will use women techeu support to liaise with these stakeholders develop commercial relations with them and build a regulatory compliance strategy for share all of these will be leveraged to get contact with and secure the investment needed to complete share development and bring it to the market
t cell regulation by fed state bacterial metabolites

intestinal microbial communities expand the functional capabilities of the host via their metabolic attributes from energy harvest to the production of vitamins the gut microbiota shapes mammalian physiology and is often considered a postnatally developed organ yet the microbiome poses a formidable challenge to the immune system how can we host trillions of bacteria without mounting an inflammatory response gut immune homeostasis relies on the balanced action of suppressive and inflammatory t cell subsets i discovered that bacterial metabolism of bile acids and dietary fibers promotes the differentiation of suppressive t cells given the complexity of the microbiome finding other immunoregulatory cues deployed by gut bacteria and their mechanisms of action remains a major challenge and the logic behind these tolerance mechanisms is not understood i will use a novel conceptual framework to bridge this gap based on my previous findings i postulate that immunoregulatory bacterial molecules are produced in response to food intake within this emerging paradigm i selected two new groups of bacterial molecules for immediate investigation and developed a strategy to identify novel putative immunoregulatory candidates based on a careful examination of microbial metabolism after food intake i will find the molecular targets of active molecules using chemical screening and chemoproteomic methods and test metabolites in vivo by colonizing germfree mice with genetically manipulated bacterial strains the proposed work is grounded on my strong expertise in hostmicrobe interactions and takes advantage of the stateoftheart biochemistry facilities at my hosting institution and of the complementary skillsets of my collaboration network this synergistic combination will allow for a comprehensive interrogation of immunological tolerance to gut commensals from metabolites and their molecular targets to their functional relevance for intestinal health
modern mediterranean archaeological regimes in a global context

contrary to conventional narratives on the history of archaeology and official museum narratives arguing that mediterranean states and societies neglected antiquities archaeological legislation was adopted for the first time in the european north and in the mediterranean modern mediterranean archaeological regimes in a global context mmare investigates the mediterranean legal archaeological regimes from 1789 to 1945 individually and comparatively it similarly traces their influence at the international level through the league of nations ln mmare contributes with novel approaches and substantive arguments to the debate on decolonizing the museum and suggests concrete tools for provenance research and ways forward in the discussion on the restitution of antiquities it is hosted by ca foscari university unive in italy and columbia university cu in the us and includes a secondment at brown university bu also in the us it is supervised by dr konstantina zanou cu and dr yannis hamilakis bu who are experts on the debates on mediterranean heritage as well as dr matteo legrenzi unive who specializes in international organizations and the modern middle east it also benefits from the specialized courses library resources skills training and communications opportunities as well as the vibrant academic communities of these three institutions
open fan for environmental low impact of aviation

reducing smr aircraft environmental impact is a priority of the clean aviation sria which objective is to have technologies ready for the future generation of smr aircraft the engine is key in this effort and the open fan engine architecture is the most promising solution in terms of fuel efficiency to both achieve environmental goals 20 emissions reduction versus 2020 and target a rapid entry into service as early as 2035 in synergy with national programs ofelia will gather a large european consortium to contribute to the rise technology demonstration announced in june 2021 ofelia aims to demonstrate at trl5 the rise open fan architecture for the smr to achieve or surpass the air transport action groups goals on the way towards carbon neutrality by 2050 to this end ofelia will focus on this high trl full scale demonstration of the engine architecture and on the development of key enablers for the open fan ofelia will allow installation of an increased fan diameter on a conventional aircraft configuration thanks to innovative turbomachinery technical solutions following the architecture definition ofelia will perform a largescale open fan engine ground test campaign deliver flightworthy propulsive system definition and prepare an inflight demonstration for the phase 2 of clean aviation the project will also optimize the engine installation with the airframer and address certification in close collaboration with airworthiness authorities taking advantage of the permittofly activity ofelia will then deliver a trl5 open fan engine architecture for smr demonstrate a credible path to 20 co2 reduction versus 2020 and prepare the path to flight tests to consolidate the roadmap for eis2035 as part of the technology maturation plan the compatibility of open fan to hydrogen will be investigated in coordination with h2 pillar
agedependent nutrient priming of the premetastatic niche

metastasis is the leading cause of death in cancer patients aging is an important risk factor for metastasis formation yet the underlying processes remain poorly understood given the increase in aging populations worldwide elucidating mechanisms of agepromoted metastasis formation is an important and timely topic addressed in this proposal recently the fendt group has pioneered the concept that tumorsecreted factors tsf induce nutrient priming of distant organs for metastasis formation this concept is exemplified by adaptations in lipid metabolism of target organs triggering a prometastatic signaling pathway in invading tumor cells i propose that nutrient priming is agedependent as the metabolism changes with age contributing to the enhanced risk of metastasis formation in the elderly i will investigate this concept using melanoma as a prototypic cancer of agedependent aggressive metastatic behavior i will address 3 specific objectives 1 identify agedependent metabolic response of distant organs to tsf using mass spectrometry imagingbased spatial metabolomics in young and aging mouse models and corroborate my findings in melanoma patients 2 elucidate molecular mechanisms whereby identified metabolites promote the premetastatic potential of the distant niche by applying genetic screens as well as multiomics and functional assays to spheroid models of metastasis 3 validate the therapeutic potential of intercepting agespecific metabolic priming using pharmacological and genetic perturbations in mouse melanoma models ultimately i expect to identify agespecific metabolic adaptations in premetastatic niches and to document that these pathways provide targets for personalized therapy of metastatic tumors in the elderly this ambitious proposal is based on my expertise in elucidating the instructive role of metabolites in cell fate and function and on expert skills in cancer metabolism research that i will acquire in the fendt lab
developing a culture of whistleblowing and empirical examination of whistleblowing mechanisms

whistleblowing is one of the most effective means of exposing and deterring wrongdoing even though those who blow the whistle on such misconduct are often subjected to social and organizational stigma despite their vital role in uncovering corruption they face reprisal demotion harassment and even dismissal from their jobs as whistleblowers disclose organizational misconduct internally andor externally to create and sustain a culture of integrity and transparency organizations must establish effective whistleblowing channels that encourage speaking up without fear of retaliation this project aims to positively transform perceptions toward whistleblowers through normative ethics training compare the effectiveness of whistleblowing mechanisms across the world and develop internal reporting mechanisms that consider the psychology of potential whistleblowers to create a culture of whistleblowing this project fills significant gaps in examining the psychology behind whistleblowing and moves beyond existing scholarship by integrating global and local perspectives and mechanisms for whistleblowing and connecting business ethics organizational behavior and law literature to foster a culture of whistleblowing through investigating the psychological perspectives on whistleblowing and integrating the whistleblowing mechanisms in the european union the united states and beyond the project offers unique opportunities for internal whistleblowing mechanisms in turkey and europe
smart immune protcell firstinclass allogeneic thymus empowered t cell therapy platform for fast and durable immune system reconstitution

allogeneic hematopoietic stem cell transplantation allohsct is used in immunodeficiencies blood malignancies though costly hardtoaccess linked to many severe complications smart immune puts forth a highprofile solution to solve this gap protcell platform supplies clinicalgrade allogeneic lymphoid progenitor cells produced in just 7 days exvivo these are made into tolerant polyclonal mature t cells by the patients own thymus in a record 3 months vs 1524 months naturally reducing complications since infused in our 1st patient june 2020 with strong ip orphan drug label secured traction across eminent kols in 7 countries we face a window opportunity with the eics support we pursue the less attractivetovcs scid indication as part of our series a to become a front row tcell therapy player with future chimeric antigen receptor car therapies in mind we project to treat 40k patients by 2030 recover a roi of 528 over our target series a
participatory democracy that scales

civil society and public authorities from all levels of government are increasingly turning to digital democracy tools to improve citizens participation in democratic processes and the legitimacy of policy decisions at the same time digital democracy technology today is not yet fit to meet the lofty goal of providing an allround democratic infrastructure that can reempower citizens and make public administrations more relevant and responsive to the citizenrys wills and needs this is because digital democratic technology is currently developed and deployed while we still lack evidencebased methods to design assess and validate it we still lack the knowhow to discern which specific technological solutions best foster inclusive meaningful and scalable democratic participation and under what conditions perycles tackles the challenge of developing such knowhow analyzing and testing platform designs on an opensource software for democratic deliberation that can be deployed at multiple levels of governance from local to national to transnational to do so we develop a firstofitskind interdisciplinary approach to the design of digital democracy technology which integrates methods and concepts from democratic theory the social sciences and the computing sciences the outcome of the project will be threefold first a set of methods to assess digital democracy solutions in a principled manner second readily available opensource implementations of digital democracy solutions that meet the identified standards third a library of best practices and recommendations for the design and deployment of online participation platforms targeting digital democracy practitioners citizens and decisionmakers