Dragon09/odtu_chatbot huggingface dataset:
mechanicsaugmented brain surgery

this project aims at revolutionising the treatment of brain disorders through mechanicsaugmented brain surgery magery due to the ultrasoft nature of brain tissue surgical procedures have exceptionally high requirements for minimal invasiveness and maximal safety during the procedure brain tissue largely deforms and is easily loaded beyond its functional tolerance a promising technology to improve surgical outcomes is to integrate virtual information either through immersed virtual reality vr in training and planning or through augmented reality ar overlaying virtual information with the surgeons real view despite rapid advances to date most vrar solutions have disregarded the complex regiondependent mechanical properties of brain tissue and mechanicsinduced cell dysfunction or death the magery project will follow a new paradigm by focusing on brain mechanics we imply that we can minimise unnecessary brain tissue damage by integrating continuum mechanicsbased simulations into vrar solutions realising this objective will require to combine stateoftheart approaches in live cell imaging nonlinear continuum mechanics and computational engineering the applicant and the magery team will for the first time perform simultaneous largestrain mechanical measurements and multiphoton microscopy and through modelling and simulations identify thresholds for tissue and cell damage under complex threedimensional loadings by merging simulation results and vrar techniques this project strives towards realtime predictions of brain tissue deformation and corresponding damage with her pioneering role in testing and modelling the complex behaviour of human brain tissue the applicant has excellent prerequisites to tackle these challengesif successful this project can not only revolutionise vrar for brain surgery but also leverage our understanding of the cellular response to threedimensional mechanical loading across length and time scales
education diversity innovation and politics

the introduction of free and universal education accessible to diverse religious and cultural groups has been a major achievement worldwide and a crucial factor for economic development however still today many countries do not guarantee full access to education religious minorities often face restricted learning opportunities and top educational institutions are being dismantled if they dissent from governments policies the overarching goal of edipo is to study these extremely important phenomena through the lenses of quantitative economic history focusing on france from the 1789 french revolution to the 1900s this was a period of educational reforms key for french and more broadly for european modernization the innovativeness of this proposal is twofold i it constructs groundbreaking micro data from archival and secondary sources of similar quality and detail of modern data but for a longer time horizon ii it identifies unique historical episodes to assess causality and to study the longterm effects edipo is composed of three projects project 1 studies the process of expansion of mass education from its demand to its consequences project 2 asks how discrimination affects schooling choices of religious minorities project 3 documents the impact of dismantling a highquality but dissident educational institution on human capital innovation and political outcomes edipo speaks to economists economic historians and political scientists it sheds light on past and current instances of expansion and secularization of education and it contributes to important public debates eg the importance of achieving universal education the increasing diversity of our society and the discrimination often faced by minority groups and the dismantling of institutions training outstanding but dissident scholars
better understanding intensified engagement training and development in regional biobased systems

engage4bio will strengthen circular sustainable bioeconomy and sustainable regional development through engaging quadruple helix actors taking into account their diversity of societal economic and cultural perspectives from five regional biobased systems and five associated regions in processes of design thinking cocreation retraining and skills development based on their regional specificities availability of biomass feedstock level of technology planetary boundaries and social capital activities will be cocreated performed and reshaped to their best advantage for each region the regional biobased systems focus on the five major value chains namely circular and biobased textiles nl agriculture and agrofood industries hu wood and interior at biobased and sustainable packaging fi and blue bioeconomy it the embedding art and design in the activities the framework will boost the uptake to a strengthen local governance feedback loops and respective governance models b to increase design thinking and cocreate formats for training retraining mentoring and skills development and transfer fostering understanding and engagement in biobased systems c to cocreate communication and awareness campaigns the cocreated and implemented activities result in fully open initiatives that advance skills transfer and development activities like re training formats or mentoring programmes for various relevant stakeholders in biobased value chains and encourage the inclusion of citizens knowledge and perception as well as the engagement of citizens boosting a betterinformed decisionmaking process and enhancing engagement and innovation thus engage4bio framework will be designed in a transferable way considering regional natural and cultural differences and will be applicable in different european regions also thanks to the involvement of networks and regions the partners include
natural deep eutectic solvents for sustainable bioplastics

petroleumderived plastics produce greenhouse gas emissions ghgs the primary cause of climate change at every single stage of their life cycle on the contrary plant biomass is produced via photosynthesis which involves the transformation of carbon dioxide one of the ghgs water and light into chemical bonds therefore using plant biomass to produce bioplastics removes carbon dioxide from the atmosphere and keeps it stored throughout the products useful life therefore neoplastics aims to valorize highly available lowcost and nonedible lignocellulosic and nonlignocellulosic vegetable waste to prepare bioplastics that represent an alternative to the traditionally used petroleumderived polymers for agricultural and packaging applications specifically this project will study the role of natural deep eutectic solvents nades as facilitators for transforming biomass into bioplastics these compounds are gaining importance as solvents for vegetable waste valorization they are usually used for biomass fractionation and only a few recent works have reported their use in transforming natural polymers into bioplastics by acting either as solvents or as plasticizers these researches represent only a starting point for what it is possible to do with these innovative solvents whose main advantage is that it is possible to tune their physicochemical properties by varying the nature and ratio of their constituents which in turn can lead to a wide range of materials properties for different applications the project introduced here is highly ambitious it will not only provide advantages such as zero waste generation contribution to the circular economy and a low carbon footprint manufacturing process but it will also boost the career of the experienced researcher and enrich the knowledge and experiences of both the researcher and the host institution impacting positively on the scientific community the civil society and the business sector
link4skills

link4skills is a global research and innovation project on skill shortages the acronym reflects the objectives of the call by linking for4 fair skill matching it embeds 4 processes of responding to skill shortages reup skilling of established populations incl migrants and inactive women raising wages automation and migration it considers 4 continents europe africa asia and america where skill shortages and skill flows will be analysed it develops the aiassisted skill navigator for stakeholders from employment vocational training organisations in origins and destinations link4skills will scrutinize a how to identify the existing and emerging required skills in changing labour markets b how the eu should respond to skill shortages c how to recruit the required skills from various pools either from the existing workforce including established migrant populations and inactive women also supported by automation and from the workforce from noneu countries the project combines data on skill gaps and matching in the eu with analyses about human capital in origins investigates emerging and established migration skill corridors between eu and india morocco ghana nigeria philippines indonesia and ukraine in order to make enriched inventories of skill partnerships the project achieves its aims via econometric microsimulations based on eu databases combining skill supply and demand and by data collections and stakeholders expertise oversees the knowledge will be nested in the aiassisted skill navigator trl5 which is a knowledgebased expert system that goes beyond existing policy dashboards it is an open access system available to public it is cocreated by labour market stakeholders in every partner country partners will take care about stakeholders involvements in the project by enhancing tailormade communication and dissemination the project will also produce link4skill podcast series and academic outlets
ultrafast control of interlayer coupling of twodimensional layered materials

layered twodimensional materials are novel quantum materials considered as the basis for futuregeneration electronics the electronic and optical properties of such materials critically depend on socalled interlayer coupling the interaction between the neighboring atomic layers within the material what is of particular interest is that one can modulate this interlayer coupling and thereby the materials properties by applying an electric field in the outofplane direction of the atomic layers in this project i focus on a typical semiconductor layered material called transitionmetal dichalcogenides tmdc in tmdc bandgap modulation with dc electric fields was recently achieved however the limitation of the modulation speed remains yet unclarified in addition the expected insulatormetal transition at the strongfield limit has not yet been realized because the required strong field causes a dielectric breakdown of the materialthis project aims to 1 realize ultrafast control of electronic properties of layered materials via direct ultrafast manipulation of interlayer coupling 2 identify the speed limitations to this controlling mechanism and 3 realize the insulatormetal transition in the layered material via the ultrafast control scheme to investigate the ultrafast dynamics i will utilize the terahertz technology which enables us to apply a very short pulse of an electric field a terahertz pulse to the material and observe the change of its optical properties in an ultrafast timescale a newly proposed micrometersized device which converts an incident terahertz pulse to a strong outofplane electric field on tmdc will enable ultrafast property controlthe proposed scheme will be applicable for the ultrafast control of quantum phases in various layeredmaterial systems it is also expected to be applied as optoelectronic and alloptical ultrafast switches which are important milestones for future ultrafast technologies
customized games and routes for cultural heritage and arts

along with the tourism industry cultural and creative industries ccis are most affected by the pandemic all ccis need systems or management tools to make them more resilient today thus culturati aims to build an inclusive culturaleducational ecosystem with visitor and capacity management by using digital solutions and cuttingedge technologies to 1 enhance and support collaboration between ccis and citizens to promote europes culture values and interests 2 increase accessibility awareness and understanding of cultural heritage and arts 3 preserve cultural heritage by preventing deterioration due to overcrowding and sustain valuable resources 4 enhance the audience experience through customized games and routes by optimizing the number of people on the venue or sitebased ccis ensuring social distancing between them in case of a pandemic culturati is a global content platform that enables ccis creative professionals and citizens to create content collectively for cultural heritage and arts across europe consequently culturati curates content in its database and delivers customized information with the help of its algorithm therefore the principal objective of the culturati project is to design develop evaluate and validate mainstream technologies for its ecosystem utilizing the internet of things cloud and mobile technologies sensors people counters and artificial intelligence our usercentered design methodology situates user needs at the center by actively involving them in five pilot sites across europe to validate culturati as well as increase engagement with broader audiences accordingly our interdisciplinary consortium involves computer scientists ccis academia from various disciplines including social sciences smes public authorities and nonprofit community initiatives to focus on engaging citizens and ensuring widespread communication and exploitation of culturati in europe and internationally
adaptive redox regulation in inflammatory macrophages

macrophages are key players of the innate immune system and as such maintain homeostasis initiate inflammatory and redox responses for pathogen defence but also regulate resolution of inflammation supporting these functions are distinct metabolic programmes which underlie macrophage functional phenotypes while recent advances have improved the understanding of macrophage metabolic programmes supporting specific activation states it remains unclear how the redox system is regulated in macrophage activation states and during pathogen defence here i propose to investigate how redox adaptation is regulated during macrophage activation and its impact on functional phenotypes i will focus on the following three aims firstly i will quantify expression of cystine transporter slc7a11 which by importing cystine supports glutathione and coenzyme a synthesis this will allow a better understanding of the role of cysteine during redox adaptation in comparison to the wellknown heme oxygenase 1 ho1 secondly i will disrupt key regulators of redox adaptation including slc7a11 and ho1 to investigate their effect on macrophage functional phenotype this will identify key nodes for redox adaptation in different macrophage activation states thirdly i will investigate the temporal profile of electrophilic stress and redox adaptation in response to macrophage activation and during bacterial infection overall this project will contribute to the detailed understanding of redox adaptation during macrophage activation which is essential for pathogen defence and protection from oxidative stress furthermore identification of new drug targets for redox regulation in macrophages would provide the basis for novel therapies for oxidative stress induced pathologies
advanced sustainable biofuels production from purified microalgae and oleaginous yeasts via integrated solar hydrothermal liquefaction

sunfusion endeavors to comprehensively address a novel process of microalgae and oleaginous yeasts conversion into shipping and aviation biofuels by advancing stateoftheart core technologies i innovative pbr and open raceway ponds for microalgae and yeasts cultivation and optimization ii a concentrated solar thermal cstcoupled continuous hydrothermal liquefaction htl reactor with solar energy covering the thermal needs of the process iii a solaraided thermal energy storage tes system which at later stages will be fully integrated to the overall process iv hydrotreatment units to obtain the final advanced sustainable biofuels v recovery of gaseous and aqueous streams from htl and synergistic cultivations of microalgae and yeasts that will be recycled to the microalgae cultivation leading to a zero emission and zero waste process htl is a thermochemical process used for the production of sustainable biofuels from the depolymerization and repolymerization of highly moist organic biomass having the inherent advantage of avoiding the costintensive part of biomass drying these points will introduce highriskhighreturn novelties that will play an impactful role in forwarding the process subcomponents to trl 4 at least 7 l of biocrude from microalgae and 1 l from yeasts are planned to be produced and upgraded a testing period of above 12 months will take place under onsun conditions at temperatures exceeding 350oc with the solartobiocrude energy efficiency target set to exceed 50 which is an ambitious number that will allow the sustainable transformation of solar energy to energy carriers in the form of biofuels finally an overall process assessment will take place to evaluate the technology in terms of technical economic and environmental aspects the visionary concept beyond sunfusion project envisages the integration of the main components of the process in a mobile platform that will be operational in offgrid places
luxembourg hydrogen valley delivering integrated fullchain sustainable hydrogen ecosystem with technical economic social and environmental benefits and superior replicability

luxhyval launches a flagship hydrogen valley in luxembourg to boost the penetration of hydrogen by deploying green hydrogen initiatives across the entire value chain from local production to utilisation including storage and distribution for a range of applications targeting industry and mobility while also aiming to connect with existingplanned infrastructures business models regulation and commercial negotiations are defined safe design and operation are ensured to deliver certified green hydrogen luxhyval produces 650 tony that are used by several enduse applications in the mobility ie private public buses light industrial vehicles and industry ie metal and glass manufacturing sectors using 69 and 31 of the produced hydrogen respectively strong commitment of key commercial actors along the entire value chain and political support in line with the luxembourg hydrogen strategy aimed at fully decarbonising the industrial sector before 2030 is ensured as demonstrated by 80 cofinancing from external sources it generates different investments exceeding 38m significant econonomic social environmental and political impacts are achieved digital twinning for optimal planning and operation is delivered to support upscaling and replication while public perception and professional upskilling deliver social benefits and equip the workforce with the needed competences lastly the lessons learned and solutions are replicated in 2 follower valleys in central cz and eastern ua europe the consortium include 19 partners from 7 countries 6 from europe plus australia aligned with the clean hydrogen mission covering the entire value chain including energy engineeringintegrator network operators technology providers supplier of green electricity end users in mobility and industry and rto experts in digitalisation public acceptance environmental assessments innovation management and replicators from the follower valleys
empowering eu rural regions to scaleup and adopt smallscale biobased solutions the transition towards a sustainable regenerative inclusive and just circular bioeconomy

climate change will require concerted innovative ideas and actions at the localregional level a sustainable european bioeconomy will not only ensure the protection of the environment and biodiversity but will also drive the renewal of european industries the modernisation of primary production systems and lead to the creation of jobs particularly in rural areas through the active participation of all regional stakeholders in their local bioeconomies ruralbioup project will strengthen the cooperation among regional key actors and knowledge holders empowering them to establish an inclusive and longlasting ecosystem the ruralbioup regional hubs to support the mainstreaming of biobased business models in rural areas in particular ruralbioup will establish 9 regional hubs 30 stakeholders per hub in 6 eu countries that will codesign and implement 9 action plans on 18 value chains regional hubs will be empowered by ruralbioups partners with mentoring coaching and training activities in the implementation of their action plans thanks to this at least al 1000 innovators will be supported through networking events and study visits and al 50 new collaborations fostered eg partnership agreements between companies andor farmers solutions funded etc to adopt smallscale biobased solutions in rural areas the project will leverage synergies between existing eu networks eubionet bioeast etc clusters and regional organisations and will build upon previous research results power4bio berural enabling transition2bio biovoices etc by integrating and extending the existing knowledge and data in order to propose different rural business models and new biobased value chains in the targeted regions through the realisation of a digital tool the ruralbioup onestopshop supporting regional actors to take sciencebased and informed decisions
circular bioeconomy transformation for regions by enabling resource and governance networks

biotransform provides european policymakers with an adequate assessment and policy development framework knowledge base and expert support ecosystem to accelerate the transition from linear fossilbased systems to circular biobased systems it is therefore operating at the interface between the circular economy and the bioeconomy transitions in this way biotransform equips policymakers with the tools to set informed priorities that serve environmental economic and social goals being actionable futureproof and align with supplyanddemand trends in related industries and value chains biotransforms assessment package will be tested by and provided for european policymakers which will include 3 complementary tools i resource flow analysis tool including circular innovations ii a cuttingedge quick environmental social and economic assessment tool and iii a logistics management tool to achieve this biotransform develops and tests its framework to establish and roll out circular biobased systems by applying a multiactor approach around 6 regional cases andalusia spain northern burgenland austria western macedonia greece finland charles spa region czech repulic and north rhinewestphalia germany these regional case studies represent several important industries and scenarios for europe such as forestry agrifood lake ecosystems lignite and minerals and chemicals action roadmaps will consider specific regional available resources and infrastructures conversion pathways logistics current policies strategies and access to finance in other words biotransform builds on the concept of regenerative bioeconomy value cycles by tapping into what is there already and connecting the dots in this concept carbon is stored and nutrients are recovered this concept shall be upscaled and replicated to many further european regions to achieve europes ambitious goals