Dragon09/odtu_chatbot huggingface dataset:
spatial and temporal regulation of cell competition

every tissue in our body is a mosaic formed by individual cells that have different levels of cellular fitness competitive interactions where the relative differences in fitness determine cell survival therefore have a major impact on the physiology of a wide variety of tissues cell competition is versatile and abundant and it impacts a broad spectrum of processes ranging from early embryonic development to aging yet due to the heterogeneity of competitive interactions both in space and time the dynamics of this process are difficult to unravel for instance it is unclear which longterm adaptations of cellular behavior cell competition induces furthermore the consequences of a locally activated response on overall tissue fitness are unknown the overall objective of this project is to unravel spatial and temporal regulation of cell competition specifically i aim to understand the1 cell competitiondriven adaptations of cellular behavior2 mechanistic regulation of competitive cellular interactions3 contribution of cell competition to tumor growth in different tissuesthe foundation of this project is formed by our innovative 3d coculture system which my team developed to dissect competitive behavior at molecular cellular and population scales we will combine this system with a newly generated toolbox to recognize and manipulate interacting and competing cells by leveraging our leading expertise in longterm quantitative imaging and single cell multiomics we will mechanistically untangle cell competition in primary intestinal cancer in space and time to understand how competition affects different types of tumor growth and find shared regulators of this process we will expand our coculture systems to different tissues together this provides the unique opportunity to tackle a fundamental question in cell biology how is cell competition regulated in space and time and how does this impact tissue composition and tumor growth
valence asymmetries the positive the negative the good and the bad in language mind and morality

an asymmetric behavior between the positive and the negative has been evidenced in psychology for information processing attention recognition and decision making in philosophy for judgments about morality and intentionality and in linguistics for a range of lexical syntactic semantic and pragmatic phenomena negative information grabs our attention we process it more carefully we recall it with greater precision we easily blame others for the negative sideeffects of their actions but do not praise them for the positive ones it takes many nice words to overthrow one nasty remark when we say that something is not good we usually imply that it is bad but by saying not bad we do not imply that it is goodvalence asymmetries have arisen on many horizons but have seldom been brought into correspondence and are at odds with most theories of value the present project is a pioneering attempt to secure the premises for a crossfertilization between the different accounts of valence asymmetries it will deploy methods from philosophy argumentation and conceptual analysis formal semantic and valuetheoretic models and experimental methodology from psycholinguistics and moral psychology it has three main objectives highlight the fundamental role that valence plays beyond emotion in particular in value judgments and language
sensor islet organoids silorgs for in vivo identification of antidiabetic drugs

to develop new drugs for treatment of diabetes there is an immediate need for an in vivo approach allowing the assessment of cell function and survival in the living organism noninvasively longitudinally and at singlecell resolution we therefore transplant genetically engineered sensor islet organoids into the anterior chamber of the eye of mice for functional microscopic imaging using the cornea as a natural bodywindow following their engraftment various aspects of cell function and survival can be readily imaged in these organoids functional studies demonstrate that engrafted islet organoids in the eye respond to the diabetic milieu of diabetic mouse models we have extensively in vitro tested fluorescent biosensors that reflect keyevents in cell function and survival following intraocular transplantation of mouse and human islet organoids expressing biosensors in their cells into healthy or diabetic mice they will allow noninvasive longitudinal in vivo monitoring of 1 glucose responsiveness 2 ca2 handling 3 functional cell mass and 4 proliferation based on the in vitro tested biosensors the major objective is to establish a robust pharmaindustry in vivo imaging platform for validating newly developed diabetes treatment leadcompounds in early drug development this screening service shall be performed on a commercial basis the milestone of this proposal to be achieved within 18 months is the validation of the sensor islet organoidbased in vivo platform for testing the effects of new potential diabetes medicines on human cell function and survival in normal and diabetic mice
why are the big two of agency and communion so fundamental to human psychology an agencycommunion theory act of social learning and cultural activity and its novel account of social influence

the big two of agency influence resourcefulness authority and communion benevolence prosociality honesty are fundamental to human social cognition the selfconcept and personality the big two must have a tremendously important function for humans otherwise they were not that fundamental to human psychology yet what is this function stateoftheart answers explain the function of the big two either in social cognition or in the selfconcept or in personality and those answers contradict each other in critical ways here i propose the first allencompassing answer to the functional question of the big two in social cognition and the selfconcept and personality my answer comes in the form of a novel theory agencycommunion theory act of social learning and cultural activity according to act the big two are the chief enablers of highfidelity social learning never before have the big two been considered relevant for highfidelity social learning but the latter is widely seen as the reason for humans capacity to build culture and thrive by cultural activityhumans most powerful evolutionary strategy thus act considers the big two the essential building blocks of human cultural activity and ultimately of humans extraordinary evolutionary success acts novel portrayal of the big two entails a wide variety of previously unforeseen behavioural consequences including a novel account of social influence the stateoftheart account presupposes the existence of an innate tendency to conform to majority norms act questions the existence of such an innate tendency and offers an alternative with farreaching implications for many theories across social sciences and urgent societal challenges in the sphere of social influence my interdisciplinary team will empirically test act and its novel account of social influence we will use new tailormade methodology in laboratory experiments formal evolutionary models big data and panel studies
marine protected areas europe

we will map the optimal locations for marine protected areas mpa in european seas using measures covering the range of biodiversity from species to ecosystems including habitats the contribution of these measures to carbon storage will be quantified and mapped the top 10 and 30 of the area that includes most species habitats and ecosystems and maximises blue carbon benefits will be prioritised as an mpa network the geographic scope is the atlantic exclusive economic zones of the eu and its neighbours and all of the mediterranean baltic and black seas feedback from marine spatial planning msp stakeholders in the regional seas on the proposed mpa network and methodology will be reported a first datadriven classification of ecosystems in european seas will use environmental data from copernicus and emodnet environmental niche models will map thousands of species and biogenic fauna and flora structured habitat ranges and add to existing seabed habitat maps in emodnet analyses of spatial relationships between biodiversity measures and evidence of carbon storage will support the prioritisation analyses parallel modelling of current connectivity and the velocity of climate change will map connectivity within the proposed mpa network and how it will accommodate species distribution shifts due to anthropogenic climate change all data and maps will be freely available through emodnet the ocean biodiversity information system ec knowledge centre for biodiversity and the projects online atlas the atlas will provide transparency traceability and enable reproducibility of the results its synthesis will show stakeholders msp ngo students researchers why areas have been prioritised the use of decision support software will enable alternative network designs based on stakeholder preferences and could thus support wider msp beyond the subject and study area
between london cyprus and palestine waste history in the british eastern mediterranean

the project between london cyprus and palestine waste history in the british eastern mediterranean blocyp aims to uncover the origins of waste treatment policies in the region it is the first comprehensive waste history study in the modern eastern mediterranean focusing on cyprus and palestine as case studies it examines sanitary challenges faced by mediterranean cities under british rule during their rapid urbanization between the 1920s and 1940s the project investigates five major cities nicosia and famagusta colonial cyprus jerusalem tel aviv and jaffa british mandate of palestine allowing for various comparisons between countries capital cities and port cities blocyp tackles three key issues british sanitary policy regarding urban waste treatment adaptation of sanitary solutions to local conditions and needs and the role of british networks in spreading sanitary ideology and knowledge the research will facilitate a deeper understanding of british colonial sanitary perceptions and their local applications thus it is a valuable case study for territories worldwide that underwent british rule additionally it illuminates how global events such as wars and economic crises have influenced local waste treatment practices the project will utilize archival materials from nicosia jerusalem and london blocyp will contribute to three historical branches environmental history political history and history of expert networks it will shed light on the roots of modern waste pollution examine if the type of territory permanent colony or temporary mandate influenced british sanitation policy and explore the migration of sanitary knowledge between europe and the mediterranean just as our approach toward waste reflects our way of living and values it was the same a century ago therefore a key objective of this project is to raise public awareness of the need for improving environmental citizenship by learning from the past
nobula breaking the glass ceiling in additive manufacturing through laserassisted glass 3d printing

traditional glass fabrication produces medium to large sized parts typically with low resolution and simple geometry moving towards higher resolution and more complex structures becomes increasingly more challenging and expensive or is simply inaccessiblenobula3d printer with its unique and patentpending direct glass laser deposition dgld technology is the first commercial system that can directly 3d print glass from a glass filament without the need of postprocessing it enables costefficient printing of highly customized and complex glass parts with short leadtime the printers require no infrastructure offering unique possibilities to transform glass fabrication in ways not possible todaywe generated initial market traction as we have offered prototyping services to academic institutions eg lund university kth and we have ongoing discussions with interested industrial players eg scientificlab glass schott yokogawa heraeus saintgobain luxottica
statistical and probabilistic properties for weakly chaotic systems

the purpose of the project is to study limit laws and mixing properties for weakly chaotic systems the theory of strongly chaotic systems has been extensively developed in the last decades and there are now methods that can be used in studying their statistical properties eg a functional analytic approach transfer operators anisotropic banach spaces or a geometric approach distribution of stable and unstable foliations however much less is known for systems which do not have such a strong chaotic behavior and in particular are of zero entropy in the project i plan to develop general methods to study many natural classes of systems which exhibit slower or weaker notions of randomness or chaos eg suspension flows i plan to study mixing and statistical properties of such systems with the goal of characterizing their chaotic behavior and compare it with strongly chaotic systems in particular i also plan to study the infinite measure case where the theory has not yet been developed and where possibly other notions of mixing have to be developed
mapping understanding assessing and predicting the effects of remote working arrangements in urban and rural areas

rmap aims to analyze the impact of remote working arrangements rwas on the disparities between urban and rural regions in europe the project bases its research on the premise that understanding and shaping the trends related to the emergence of rwas provides an opportunity to bridge the urbanrural divide affecting its multiple facets to achieve its goals rmap will produce an integrated impact assessment framework powered by the rmap model that will allow the assessment of individual social economic environmental and spatial impacts of rwas a visualization platform will be developed leveraging the rmap model to provide visualization and interactive services allowing decisionmakers to monitor and assess how remote work arrangements affect people communities space economy and environment in urban and rural regions the developed tools will be applied at local level to monitor and assess current remote working trends across six representative usecases in the eu and the ac in regions within greece united kingdom italy turkey netherlandsgermany austriaswitzerland two crossborder cases using scenario building and forecasting methodologies rmap will move on to explore the potential future impact of remote work in these regions for the next 510 years and formulate policy recommendations on how to create environments conducive to remote work that are tailored to the needs of local governments in both urban and rural settings crossregional exchanges between stakeholders and policy roundtables will help move beyond the regional focus ensuring the replication of results across areas with different characteristics in europe and beyond by taking a comprehensive approach to research on rwas rmap addresses the role and the needs of policymakers employers workers researchers and civil society providing capacity to urban and rural regions to seize the opportunities and cope with the challenges brought by remote work
solar to value

to combat global warming achieving netzero or netnegative co2 emissions is imperative the eu aligning with the paris agreement aims to reduce emissions by 40 and increase renewables share to 32 by 2030 another challenge that the globe faces is the massive accumulation of pet plastic waste prompting the eu to seek innovative recycling solutions solarpowered photoelectrochemical systems offer a clean costeffective alternative by converting co2 into fuels while simultaneously recycling pet waste into highvalue products moreover by integrating pet oxidation it aims to overcome the substantial overpotential loss associated with conventional oxygen evolution reactions at photoanode making the process more efficient therefore solartovalue solva missions to develop a coplanar photocathodephotoanode architecture based on halide perovskites creating an interdisciplinary solution for an efficient pec co2rpet oxidation system to facilitate these processes advanced and selective electrocatalysts fe and cu single atoms on ndoped carbon catalysts for co2 reduction and nifebased catalysts for pet oxidation will be integrated into the photocathode and photoanode respectively to ensure the stability of the perovskitebased photoelectrodes protective layers of ito will be deposited preventing direct contact of thinfilms with the electrolyte the successful realization of this project holds the promise of developing standalone monolithic pec cells for co2rpet oxidation this can also extend the anodic recycling process to pv modulesspent liion batteries and integrate it with cathodic co2r through proper modifications of electrocatalysts and electrolytes solva addresses two pressing global issues in a single innovative system ultimately promoting a sustainable and circular economy
quantum superexchange energy storage platform

batteries are a major driving force behind eus goal to be climate neutral by 2050with netzero greenhouse gas emissions however all batteries suffer from severe performance and safety challenges fire and explosion and fastcharging limitations due to two fundamental challenges1 the complex and uncontrollable microscopic electron and ion interactions at dynamic interfaces 2 the highly inhomogeneous electric field inside the battery cell that leads to chaotic carrier migration in this project i tackle these problems by developing a quantum superexchange energy storage platform queen which enables atomically precise fabrication of 2d hybrid nanomaterials effectively transforming them into programable matter in queen my aim is 1 developing a quantum arc pen electro pulse lithography qarc technique including a nanoscale pen arcpen with uniquely modified tips special gas inletsoutlets to removereplace targeted atoms with great precision 2 using qarc techniques investigating novel patterns to fabricate an inplane hybrid 2d material system with band gap engineering coulomb blockage and ballistic transport 3 leveraging queens near atombyatom fabrication to create an insitu testing platform to investigate quantum phenomena at complex interfaces queen will enable the development of superior battery architectures with i precise and programmable control carrier transport ii groundbreakingly thin battery operation distances 2nm5nm between anode and cathode iii very high mobilityinstantaneous ion transport iv blueprint for extra charge storage mechanism my multidisciplinary background in advanced device engineering and physics will enable me to accomplish the ambitious goals of this project which will transform battery technology going well beyond the state of art by introducing control to carrier dynamics furthermore queen unlocks the potential for 2d materials in areas like biology flexible electronics and spintronic
forecasting climate surprises on longer timescales

the greenland and antarctic ice sheets gris and ais respectively and the atlantic meridional overturning circulation amoc are prominent examples of tipping elements in the earth system that have the potential to respond nonlinearly to small changes in forcing tipping elements can thus give rise to climate surprises ie lowprobability highimpact events that may be triggered earlier than expected simulating such climate surprises and their impacts on the relevant multicentennial timescales and beyond is particularly challenging today the right methods are not available resulting in deep uncertainty in future projections here i aim to develop a novel probabilistic methodology to robustly forecast climate surprises such as icesheet and amoc collapse on long timescales this requires simultaneous advances beyond the state of the art on two fronts first a new generation fast earth system model fesm will leverage the latest advances in our understanding of key processes to represent the gris ais and amoc realistically in a coupled framework and on long timescales critically this will be the first comprehensive model fast enough to run the large ensembles of simulations needed to quantify the uncertainty associated with deeply uncertain processes second a highly novel and generalized probabilistic approach will be developed to constrain the fesm to be consistent with output from the latest generation of earth system models forclima will generate probabilistic estimates of climate surprises for the mediumterm future centuries to millennia with much higher confidence than we have today and inform about interactions between key tipping elements in the climate system this project will therefore greatly advance the state of the art in coupled climate icesheet modeling and lead to an unparalleled understanding of the longterm impacts of climate change on the earth system
center for biological invasions in forests

this proposal addresses the priorities of the call by appointing an era chair holder at the faculty of forestry and wood sciences of the czech university of life sciences prague czu dr andrew m liebhold a globally prominent scientist in the field of biological invasions the proposal aims to establish hive the centre for biological invasions in forests around the chair by hiring a team of excellent researchers and adopting an innovative work model of socioecological synthesis centres sesc this model has recently had much success in generating innovative highimpact research yet there has been only a very limited uptake in widening countries contrary to the traditional hierarchical system of research organisation sesc research is organised around working groups wg which are formed of a diverse collection of researchers and innovators from mostly outside host institutions adopting this work model in hive will deliver a considerable increase in mobility level across disciplines and sectors and facilitate a new level of cooperation between researchers and innovators involving eu and national decision and policymakers nature conservation and biosecurity experts in wg and fostering an active bidirectional interaction will profoundly contribute to the knowledgebased economy and society and strengthen the human capital base in widening countries to maximise the efficiency and impact of hive a system of institutional reforms will be adopted at czu involving administrative changes facilitating the work model of sesc fostering hives sustainability in the posteu funded period and increasing fld capacity to attract talent and contribute to reverting the progressive brain drain in widening countries reforms will be adopted to increase the capacity to compete for prestigious research grants ultimately contributing to hives sustainability a dissemination and communication strategy is proposed to maximise the spillover effect on czu and wc