Dragon09/odtu_chatbot huggingface dataset:
the experience of poverty in the postindustrial economy

the reduction of poverty is of societal importance after advances in the study of poverty in the late 20th century however most highincome countries have settled on an annual measure of household income as their primary measure of poverty in contrast exppov argues that shifting socioeconomic conditions in recent decades necessitate a new conceptual approach for understanding poverty and a new methodological framework for the collection of data related to the experience of poverty specifically exppov confronts four central tenants of poverty research first in contrast to national or regional investigations of poverty exppov proposes that the geographic distribution of poverty across neighbourhoods within a municipality is an understudied yet important source of stratification that directly affects wellbeing second this project expands measurement of the dimensions of poverty to incorporate physical and subjective wellbeing confronting the incomespecific approach that dominates the field third exppov measures the dynamics of poverty throughout the year to understand the sources and consequences of monthtomonth volatility in poverty fourth in contrast to the practice of identifying poverty as an outcome of the family market and state this project proposes that the dynamics dimensions and geographic distribution of poverty are direct sources of the morefractured family structures precarious jobs and tenuous welfare states that define postindustrial economies from a data perspective exppov introduces tools to produce lowcost panel surveys with the ability to target respondents in particular postal codes and working for specific employers such as uber or deliveroo methodologically exppov introduces a framework to evaluate the contextual effects of poverty on the core institutions of social life conceptually exppov will reset the fields understanding of the social mechanisms through which poverty is experienced and reproduced
targeting dna damage response and metabolism for precision medicine in rheumatoid arthritis

rheumatoid arthritis ra is an autoimmune disease that affects millions of people worldwide and its negative health burden is accelerating in the ageing population despite many available treatments up to 40 of ra patients do not respond sufficiently to current therapies and the needs for a precision medicine approach and new treatments are pressing the complexity of ra and unselective mechanisms of action of existing drugs are challenges current treatments also have unintended adverse effects because they affect healthy cell types in the body the proposed project ddrastic focuses on a particular enzyme called mthfd2 which plays a crucial role in the metabolism of folate and dna damage response of activated t cells recent research and preliminary data suggest that mthfd2 is overactive in ra patients ddrastic aims to address the hyperactive tcell responses at the core of ra by targeting mthfd2 with novel inhibitors that spare essential components thereby minimizing the risk of toxicity and adverse effects in parallel ddrastic seeks to understand the underlying reasons for the limited efficacy of current ra treatments and explore potential biomarkers that can predict how patients will respond to standard therapies with a specific focus on understanding the involvement of mthfd2 the aim is to introduce a precision medicine approach in ra and identify a novel treatment to achieve this ddrastic adopts a multidisciplinary approach and uses patientderived specimens ra animal models and bioinformatics analysis from large cohorts of ra patients to undergo advanced imaging cellular and molecular techniques overall these analyses aim to provide insights into mthfd2s regulatory role in abnormal immune responses and advance ra treatment by introducing precision medicine approaches and overcoming treatment toxicity
multilingual and multicultural spaces for political deliberation

as highlighted by the conference on the future of europe eu citizens at large feel that the interplay between national media discourse and politicalcultural contexts affects the perceptions and reactions to global events differently language barriers exacerbate siloed thinking the bandwagon effect group thinking and the lack of diversity in dialogue around issues of international relevance creating areas of thinking entrenched into national and language gates and hindering the creation of a truly european public sphere such challenges to democratic participation disproportionally affect members of cultural and linguistic minorities within and across eu member states the research and innovation roadmap of the multipod project aims to radically improve the political dialogue at the european level through evolving knowledge graphs and generative artificial intelligencedriven technologies that mobilise collective intelligence bridge existing communication barriers and yield a better understanding of the interdependencies between participatory processes policy decisions and behavioural thought and argumentation patterns in the public deliberation of international affairs for this purpose multipod brings together experienced use case partners as well as european networks engaged in fostering participatory deliberative democratic processes technology partners with a strong track record in multilingual language processing and leading research partners specialised in collective intelligence argumentation theory humancomputer interaction and visual methods for supporting and analysing online communication
analysis of and responses to extremist narratives

social protest movements the covid19 crisis and the war in ukraine have triggered increased polarization of debates they have challenged european democracies and thus fostered extreme narratives with strong and numerous consequences for citizens politics and the democratic exercise the arenas consortium focuses on the narratives as crucial nexuses because the battle of stories not the debate on issues cornog 2014 can determine the way that citizens react to political events a strong antagonism is constructed between extremist and mainstream narratives which is evident if we compare the narratives on the ongoing war in ukraine extremist narratives always reflect the complex intersection of spatial and temporal context where the narratives are constructed circulated consumed and reproduced they are characterized by their reliance on pathos and emotions as well as the importance of violence in them they tend to proliferate in historical periods characterized by social turmoil and construct an alternative reality and promote negative emotions and behavioral patterns that run against mainstream and official narratives in social media and through the connections between social and traditional media extremist narratives are naturalized and have an impact on mainstream narratives arenas will provide concrete responses to the consequences of these extremist narratives by i measuring and mapping the spread of extremist narratives ii defining remediation actions for individuals and groups affected by extremist narratives iii providing educational and institutional propositions to anticipate future challenges in terms of the construction and circulation of extremist narratives and iv identifying multilevel policy recommendations to help counter extremist narratives both at the institutional and political level and at the level of associations and citizens
terahertz reconfigurable metasurfaces for ultrahigh rate wireless communications

the sixth generation 6g of mobile communications planned around 2030 is expected to support innovative applications with requirements not met with todays technologies such as massivescale communications within iot the internet of senses holographic communications massive digital twinning and extreme reality full autonomous driving and flying networks considering use cases in smart cities smart home and factories eg ultrahigh precision 3d positioning with the emergence of viable thz communications systems on the horizon it is crucial to contribute thz communication and networking to the technology roadmap for beyond 6g timeframe and a step closer to industrial uptake the terrameta project aims to investigate revolutionary technologies for 6g and demonstrate the feasibility of terahertz thz reconfigurable intelligent surface ris assisted ultrahigh data rate wireless communications networks novel highperformance hardware including the thz ris and thz transmitterreceiver will be developed and advanced network analysisoptimizations techniques will be developed using these real thz components the proposed terrameta thz network will be driven by 6g usage scenario requirements and indoor outdoor and indoortooutdoor scenarios will be demonstrated in real factory setting and telecom testing field it is expected that the outcome of this project will significantly progress innovations for across the 6g technology and systems
quantum dynamics of floppy systems beyond coulomb interactions magnetic and parityviolating effects

chemistry is developed with the improvement of experimental and theoretical spectroscopy a wellknown approach for molecular vibration is based on harmonic oscillators but it cannot be used for floppy systems to analyze spectra of floppy systems the exact quantum dynamics qd methodology based on a numerically exact solution of the rovibrational schrödinger equation has been developed it may appear that rovibrational spectroscopy is well established based on the electronic schrödinger equation with coulomb interactions but two additional effects that split molecular spectra remain a magnetic interactions due to nuclear spins and b parityviolation interactions which is due to the electroweak force causing tiny energy differences between enantiomers the magnitude of a is on the order of several tens of ghz 109 hz which is observable in the highresolution spectrum the magnitude of b of a current target molecule is predicted about a few mhz 103 hz which is smaller than the current precision of the best experiments the suggestion of new target molecules with large pv effects is required these effects have been investigated for rigid systems but never for floppy systems where new coupling of rovibration and magnetic interactions and strong enhancement of pv effects may be present in this project i investigate a and b of floppy systems by developing new qd methodology and by obtaining molecular properties spinrotational constant and pv energy based on electron correlation theory the objectives of this project are as follows i formulation implementation and application of qd with magnetic interaction for floppy systems ii theory development of qd for methanollike molecules and iii qd application for chiral methanollike molecules this project provides the development of the exact quantum dynamics methodology which leads to a complete description of quantum nuclear motion in molecular systems
salt hydrate heat pipes a breakthrough in thermal energy transfer methods

heat pipes hps are one of the highly efficient passive devices used for heat transfer from one place to another recent hp technologies have shown auspicious results in several applications especially where there is limited space and the necessity of high heat flux such as in aerospace and automotive industries cooling of computers cell phones fuel production hvac systems and renewable energy systems although hps offer acceptable ranges of thermal efficiencies today achieving higher efficiencies could make a revolution in their applicability making them a dramatically more effective tool for the mentioned applications and even many others hence this project proposes a firstofitskind and revolutionary approach for the performance enhancement of heat transfer tools especially in hps the method centers around the use of salt hydrate sh materials with positive enthalpy of dissolution as the working fluid the project pursues several specific research objectives including 1 developing the first shhp using the primary choice material of nh4no3 2 finding and testing potential alternatives for the benchmark material 3 thermal and flow simulation cfd of hps in various designs with the selected materials as working fluid 4 thermal behavior optimization of the shhps 5 experimental verification of the modeling results on the shhps in the lab and 6 carrying out a risk analysis life cycle cost and life cycle assessment of the developed hps it is expected that the enhancement to be made in hps design and performance could be advantageous for a wide range of thermal energy systems especially those for the exploitation of renewable energy eg geothermal systems solar evacuated collectors etc
uncovering molecular and cellular mechanisms of immune cell trafficking across the bloodcsf barrier in autoimmunity

immune cells continuously traverse our body crossing vascular and epithelial barriers from lymphatic organs into the blood and from the blood into various tissues for surveillance or to fight infection however the brain has long been considered an immuneprivileged organ barriers protecting the brain against infection or harmful toxic agents were also thought to block entry of immune cells leaving immune functions to brainresident microglia cells this dogma was recently overturned when it became clear that immune cells cross mainly for surveillance especially at the bloodcsf barrier furthermore while harmful immune cell trafficking is a hallmark of brain autoimmunity eg multiple sclerosis and neurolupus enhanced trafficking might help to fight brain tumours and even to resolve neurodegenerative conditions eg alzheimers disease yet the study of immune cell trafficking across the bloodcsf barrier is severely hampered by a shortage of suitable methodologies we investigated bloodcsf barrier dysfunction in lupus and discovered a brain lymphoid structure with enhanced immune cell trafficking dominant transepithelial leukocyte migration through rather than in between cells will enable us to catch the trafficking events redhanded and to identify molecular and cellular trafficking mechanisms harnessing innovative methodologies involving singlecell rnaseq superresolution microscopy imaging cytometry and geneticpharmacological interventions we aim to decipher the fundamental question of how leukocytes enter the brain we will classify specialized immune and epithelial barrier cell types identify trafficking molecular pathways and develop approaches to regulate the process we will also assess this barrier involvement in the pathobiology of human neurolupus diseaseunderstanding immune trafficking mechanisms may be the key to a specialized brain portal leading to therapeutics that can modulate brainimmune interactions
nondestructive scalable smart monitoring of remote cultural treasures

argus draws on the current challenges in monitoring remote built heritage assets and the current research focus on preventive preservation and envisions the development of a a novel built heritage digital twin model to support multiscalemodal data b an advanced digitisation strategy to support the digital twin model c a portable measurements system for nondescructive physical and chemical monitoring based on miniaturised sensors and sensor composites integration comprising of ground and aereal components d aienabled methods for the modeling and identification reverse engineer of threat factors and their impact e aipowered multimodal data methods for the fusion of i remote sensing climate weather and pollution data with ii natural disaster regional statistics iii governmental statistics ii onsite acquired measurements f trustworthy ai decision support methods for the preventive preservation of built heritage argus innovation targets a researchersacademics data from the argus monitoring systems longterm status processed data the novel multimodal digital twin white paper multidimensionalmodal data visualisations apis b stakeholdersheritage managerspractitioners realtime monitoring longterm status analysis predictive preservation predictions intervention decision support c authorities realtime monitoring longterm status analysis predictive preservation strategies d general public realtime visualisations crowdsourcing and citizen contribution in preventive preservation citizensintheloop ri design with living labs and hackathons
peripheral biomarker based combinatorial early diagnostics for dementia

combidiag dn aims to develop an aidatadriven peripheral biomarker based combinatorial diagnostic protocol for early stages of alzheimers disease ad a major form of dementia and to train a new generation of fellows for this interdisciplinary field dementia a devastating disease of older age is the challenge of our lifetime and one of the societal challenges listed by the un sustainable development goals and horizon europe combidiag responds to this challenge to establish a muchneeded dn to carry out an integrated study of minimally invasive and costeffective peripheral biomarkers including body fluid markers from blood urine and saliva and digital markers from speech motor functions and sleep for developing the combinatorial early ad diagnostics the consortium comprises nine academic and eight nonacademic institutions across europe usa canada and china it synergises leading academic and industrial experts worldwide to build a triplei research and training platform for the training of a new generation of fellows to take early ad diagnostic research to a new level fellows will be trained under the vitae researcher development framework innovatively combined with the combidiag platform for triplei scientific and transferable skills as well as personal quality creative thinking and business mindset the dn has a highly innovative research programme for the discovery of peripheral ad biomarkers detection techniques aidata driven technology clinical validation and integration into trial designs the advances in combidiag research will enable a case finding tool at primary care level for helping achieve improved drug discoveries diseasemodifying treatments preventive strategies and care provision for ad combidiag will deliver 10 highlyskilled creative and entrepreneurial fellows setting them on a path to successful careers in academia or industry to ensure that the medical and societal challenges imposed by ad are met
innovative photodetector module for advanced hybrid magnetic resonance imagingpositron emission tomography scanners for nuclear medicine

the development of modern methods of medical diagnostics is an integral part of the work and research of scientists and it is constantly being improved as highprecision early diagnosis increases the chances of recovery for people suffering from dangerous diseases one of the key developments in this area is a new hybrid pet mri machine that provides simultaneous magnetic resonance imaging and positron emission tomographythe successful implementation of the project will be ensured by a coordinated exchange of experience and knowledge gained in the field of physics technology and engineering by strengthening modern knowledge in the field of optoelectronics and applying modern technological approaches and methods as well as international cooperation of highly qualified scientists and engineers from portugal czech republic turkey ukraine azerbaijan and russia this consortium will assess both technological for example development and production of highly sensitive detectors and fundamental mechanisms of internal amplification of ultraweak photosignals issuesthe project participants have many years of experience in the development of semiconductor optical devices research of detection methods the successful implementation of this project will lead to the scientific development of highsensitivity detectors of a new generation and as a result to the creation of advanced detection devicesthe aim of the project is to develop a highly sensitive prototype of a detector module for a new generation of petmri scanners within the framework of this project the collaboration will carry out both research and technological components through multipurpose business trips
the influence of schools on the offtime transitions to parenthood and partnership

becoming a parent and moving in to live with a partner are major life events determining individuals life chances and outcomes transitioning to parenthood and partnership at very young age also called offtime transitions have been linked to adverse outcomes along the life course a potentially key influence on offtime transition to parenthood and partnership are secondary schools and classmates as adolescents spend a large part of their time in school surrounded by their peers project schoolandtransitions will be the first to investigate the role of secondary schools and classmates in offtime transitions to parenthood and partnership this project aims to gain a complex understanding of the influence of schools and classmates and its interaction with individuals characteristics and family backgrounds to achieve this i set three objectives 1 decompose the effect of the school as a social context and the effect of peer influence of classmates 2 examine if and how can classmates and school contexts mitigate or exacerbate the influence of family background and 3 assess how the effect of classmates and school contexts changes over the years since leaving the secondary school
ultrasonic guided wavebased ndt of hydrogenloaded pipelines

hydrogen is seen as secure clean and inexpensive energy of the future to this aim the european union has laid out strategies for largescale production and deployment of hydrogen in the future this translates to the most economical way of transmission of hydrogen through existing natural gas pipelines however one of the serious issues that can present a setback to this ambitious project is the failure of pipelines due to defects one such lessaddressedhardtodetect failure mechanism called hydrogen induced cracks hics is considered for the proposed work in order to detect hics in hydrogenloaded gas transmission pipelines an ultrasonic guided wave ugw based ndt technique will be developed towards this a torsional guided wave mode will be optimized for its frequency from the perspective of defects hics in pipe segments using the scaled boundary finite element method sbfem simulation tool available at bam an array of shear mode piezocrystals for the optimized frequency will be used in the generation of the torsional mode towards ugw based testing pipe segments with actual hics will be prepared at hydrogen test rig at bam under the guidance of bams material scientists additionally pipe segments with artificial notches simulating hics will also be prepared further laserbased measurements will be carried out to map the wave fields around the crack to understand the physics of wavedefect interaction further the effect of operational conditions of a pipeline such as pressure and temperature on torsional mode will be studied using both experiments and simulation overall the project will involve both simulation and experiments to gain deeper understanding of the problem emphasis is also given on the validation of simulation results for the smooth progress of the project furthermore ultrasonic phased array testing will also be carried out to successfully validate the ugw measurements pertaining to defects and to localize and size them