Dragon09/odtu_chatbot huggingface dataset:
identification of novel therapeutic approaches to target the immune checkpoint protein b7h3

immunotherapies have revolutionized the treatment of multiple cancer types in the last decade nonetheless nonsmall cell lung cancer and triplenegative breast cancer exhibit only restricted response to immune checkpoint blockade especially in advanced tumor stages clinical options are limited and novel approaches to enhance antitumor immune responses are needed the immune checkpoint family member b7h3 pdl3 is frequently upregulated in cancer cells studies have shown that b7h3 promotes tumor growth in a cancercell autonomous fashion and inhibits immune cells in the tumor microenvironment despite being an important clinical target its posttranslational regulation and functional interactors on t cells are poorly understood the proposed project aims to identify novel approaches to target b7h3 by harnessing the ubiquitin system and to identify b7h3s interactors on human t cells with the objective of enhancing clinical treatment options for cancer patients my experience in solid tumor biology and antitumor immunity paired with the host labs expertise in studying the ubiquitination system will be a great catalyst for the proposed project enhancing its likelihood of success this fellowship will allow me to conduct cuttingedge research at the center for translational cancer research of the university clinics rechts der isar of the technical university of munich tum a renowned research institution with a wellrecognized supervisor prof bassermann allowing me to expand my international network scientific skills as well as leadership and management skills ultimately this fellowship will be a tremendous stepping stone in my scientific career it will bring me closer to my goal of becoming an independent researcher working at the interface of cancer biology protein biochemistry and cancer immunology where i can put my own projects into practice and train the next generation of international scientists
palomera policy alignment of open access monographs in the european research area

academic books continue to play an important role in scholarly production and research communication particularly in the social sciences and humanities as an important output of scholarly production academic books must be included in open scienceopen access policies and strategies developed by research funders and institutions to ensure that open science becomes the modus operandi of modern science across all disciplines however contrary to article publishing in journals especially in the areas of science technology and medicine academic books have not been a focus point for open access oa policymakers consequently books are only rarely mandated to be published oa by research funders and institutions palomera will investigate the reasons for this situation across geographies languages economies and disciplines within the european research area era through desk studies surveys indepth interviews and use cases palomera will collect structure analyse and make available knowledge that can explain the challenges and bottlenecks that prevent oa to academic books based on this evidence palomera will provide actionable recommendations and concrete resources to support and coordinate aligned funder and institutional policies for oa books with the overall objective of speeding up the transition to open access for books to further promote open science the recommendations will address all relevant stakeholders research funders and institutions researchers publishers infrastructure providers libraries and national policymakers the palomera consortium broadly represents all relevant stakeholders for oa academic books but will facilitate cocreation and validation events throughout the project to ensure that the views and voices of all relevant stakeholders are represented promoting diversity equity and inclusionthis will assure maximal consensus and takeup of the recommendations
identification and change of passive value markers in the laboratory and naturalistic environments

when you look at a given object are you calculating its value even if not prompted to dowhen you look at a given object are you calculating its value even if not prompted to do so most theories of valuation claim that choice prompt or in general elicitation are needed to induce valuation however the wellknown mere exposure effect dating back to 1968 suggests that merely viewing an item can induce valuation and even enhance value in this proposal i aim to demonstrate that valuation is an early and automatic process relying on visual attentional and motor systems passivevaluemarkers offers a novel framework to identify biomarkers of value of individual items passively without elicitation the aims of passivevaluemarkers are 1 identifying behavioural and neural passive markers for individual items using computational modelling in and influencing these markers 2 detecting passive markers of value in gaze pattern analysis behaviourally and in the brain using fmri 3 considering the gap that exists between laboratory studies and the real world i will identify passive value markers in naturalistic virtual reality environments the overreaching aim of this proposal is to develop a new theoretical framework on individual passive value construction and change to do so i will use a unique combination of neuroimaging computational modelling gazetracking analysis and virtual reality this research will directly address an understudied area of how value for individual items is formed by the brain without active prompt or elicitation uncovering the mechanisms of passive value representation at the single item level and individualized per participant will allow to design closed loop manipulations at the item level this approach will serve as the basis for developing novel evidencebased methods for enhanced preference modification in healthy participants and in disorders with abnormal valuation such as addictions mental illness and eating disorders
brainstem circuit ensembles for movement flexibility

movement is the shared language of behavior across the animal kingdom orchestrated by dedicated circuits throughout the central nervous system to survive animals must move with a high degree of flexibility requiring precise and rapid changes in speed and trajectory this flexibility of locomotion depends on the brains ability to select appropriate motor programs and coordinate body and appendage muscles to match the locomotor movement parameters to the behavioral context in particular the brainstem has been identified as the major site for shaping motor commands to provide this flexibility a key unsolved question is how the final brainstem commands are generated and adjusted in this project we will test a new hypothesis that challenges current views in motor control namely that the final motor commands driving the flexibility of locomotion movements are the combined product of precise interactions between circuit ensembles in the brainstem and realtime feedback from the spinal circuits our approach harnesses the powerful combination of alloptical techniques scrnaseq and electrophysiology at singleneuron resolution to determine the principles of circuit integration within and across brainstem circuits in adult zebrafish this innovative approach will allow us to uncover circuit function at a level of resolution that has never been achieved before in a behaving vertebrate animal by performing a systemwide analysis at singlecell resolution we expect to gain unique insights that will transform existing views in the field of motor control this project will chart a novel systemwide circuit blueprint for movement control and flexibility in vertebrates
development of novel single cell multiomics methods to uncover regulators of cell type specific epigenetic states

although all cells of an organism share the same genetic information they selectively access this information in a cell type and contextdependent manner epigenetic mechanisms such as posttranslational histone modifications pthms have been identified as central regulators of transcription factordna interactions during cell differentiation the distribution of pthms is modulated to enable the new cell state most of the protein complexes that position writer and remove eraser pthms have been identified but we still do not understand how these proteins are recruited to the genome and thereby dictate the specific genomic distribution of pthms previous studies were unable to identify these targeting factors as they only interact with a fraction of writer complexes at a time and likely form transient interactions thus new experimental approaches are needed to identify these proteins that are directing localised epigenetic changesin scepitarget i will develop novel singlecell methods to identify the key factors that determine celltype specific pthm deposition i will use the identified regulators to retarget pthms and evaluate their impact on cell fate decisions in stateoftheart cell differentiation systemsrecently i made a technological breakthrough by developing a method that allows the simultaneous measurement of histone modifications and total rna in single cells together with my background in genetic screening and chromatin biology this will enable me to reach scepitargets objectives the proposed techniques are transferable to study any proteindna interaction making them highly valuable for the research communityepigenetic pathways are essential for multicellular life from the beginning of embryonic development until their misregulation during ageing the identification of factors regulating pthm distribution will lead to a better understanding of their function and how they can be therapeutically influenced during pathogenes
unveiling the shadows illuminating late pleistocene humancarnivore interactions in europe

caves played a vital role for pleistocene human and carnivore populations serving as shelters scavenging sites and feeding grounds they remain the primary context preserving archeological and faunal remains in europe carnivores competed with pleistocene humans for resources and significantly contributed to cave bone accumulations and modification notably evidence of carnivore behaviors largely derives from anthropogenic contexts studied through an anthropocentric lens however carnivore remains are often invisible in the archeological register making it difficult to study them and draw precise conclusions about the level of interaction with humans and their extinction dates here i hypothesize that many species of pleistocene carnivores are present in europe for much longer than what the fossil record indicates that their presence can be assessed by revising the sediments and bones of archeological sites and that the lasting populations show signs of genetic collapse linked to population contraction therefore i propose to study pleistocene carnivores in europe focusing on iberia during and after the late glacial maximum a period marked by human population decline and climatic refugia the rich and complex archeological setting in the region will be used to identify date and delineate lasting carnivore populations this information will improve the understanding of humancarnivore interactions to do this i have designed an innovative approach uniting cuttingedge methods like high spatiotemporal precision sampling for sediment dna and paleoproteomics which combined with traditional zooarchaeological techniques overcomes the limitations of fossil availability the research has the potential to a improve the understanding and nature of the cooccurrence between pleistocene humans and carnivores and b characterize the biological process of extinction helping us improve the conservation of current critically endangered fauna
emerging nanotools for soft matter characterisation and manipulation

advanced nanotools including atomic force microscopy optical microscopy and correlative microscopy are enabling techniques for discoveries and knowledge generation in nanoscale science and technology many rd efforts have been directed towards the performance improvement of such kinds of techniques for soft matter however the greatest challenge faced by these leading edge techniques is the realization of high spatiotemporal resolution noninvasive multiscale and multidimensional imaging and manipulation we therefore propose nanoram a 10 esr marie skodowska curie action doctoral network by close collaboration between academic and industrial partners around the theme of innovative nanotools and their industrial applications nanoram will train a new generation of esrs in the development and application of newly developed manipulation and characterisation nanotools in soft matter research esrs will be crosspollinated with concepts and skills in instrumentation and soft matter characterisation in particular in fast nanomechanical spectroscopy nanorobotics correlative superresolution nanoscopy nano biomechanics and mechanotransduction these skills are applied to reveal for the first time the fast high resolution multilevel and 3d information for single cell biomechanics and nanomedicine excellent training in new scientific and complementary skills combined with international and intersectoral work experience will instil an innovative creative and entrepreneurial mindset in esrs maximising economic benefits based on scientific discoveries these specialised highly trained esrs will have greatly enhanced career prospects and qualifications for access to responsibility job positions in the private and public sectors the ultimate goal of nanoram is to consolidate europe as the world leader in innovative nanotool techniques and their emerging applications in soft matter fields such as biomechanics mechanobiology and nanomedicines
emerging pests and pathogens as a novel lens for unravelling socialecological cascades

emerging pests and pathogens epps are an increasingly disruptive force to human society that can cause large social and ecological changes far beyond their initial site of emergence three forces contribute to this growing challenge now and in the foreseeable future first potential epps are more likely to come in to first contact with human habitats as human land use expands second denser human trade and travel networks mean that epps are more likely to emerge in new regions third human technology such as biocidal agents increases risks for reemergence understanding how epps cascade across scales in socialecological systems is therefore an urgent priority but no formal approach currently exists for analysing the ripple effects at scale from their seeding to their lasting societal imprints this project aims to fill this gap in sustainability science for societythe influx project will test the hypothesis that epps commonly cascade to interact with largescale social and environmental challenges and that small differences in socialecological conditions in turn influence the likelihood and nature of epp cascades i will test this hypothesis by leveraging a comparative mixedmethods research design to assemble a large database for up to 1600 epps encompassing microbial pathogens as well as arthropod and plant pests specifically four objectives will be pursued which are to understand1the drivers of emergence risk and their connections to human environmental sustainability and social conditions 2the types of cascades that result from action aimed at governing epps3the lasting impacts epps have on societies and the conditions under which they arise4the feedbacks from 31 including through implications for social equity and environmental sustainabilityinflux constitutes a major step in situating epps in the field of sustainability science and for developing societal capacity to navigate a future characterized by them
innovative demonstrator for hybridelectric regional application

climate change poses an unprecedented challenge on todays society numerous studies highlight the urgent need to decarbonize global industry and to drastically reduce pollutant emissions across all sectors including aviation although the global environmental impact of aviation is mostly driven by smallmedium range market aircraft due to the large volume of operations the development of disruptive technologies for the power demands such applications require cannot be put in place until progressive maturation of novel enabling technologies has been achieved at lower scale or sizes the transformation of regional aviation ie aircraft serving distances of 500 to 1000 km at a capacity of up to 100 seats will thus lead the way towards sustainability and will be of particular importance both battery and liquid hydrogen powered fuel cell technology will not be sufficiently matured to allow the realization of a fully electric regional aircraft within the next decade instead an intermediate step will be required to significantly reduce ghg emissions already by 2035 the development of a hybridelectric propulsion system for regional aircraft with at least 50 hybridization represents this very challenging yet achievable intermediate step and can allow for a mission fuel burn reduction by at least 50 compared to 2020 stateoftheart regional aircraft a thermal engine that allows for usage of 100 sustainable aviation fuel will allow to reduce lifecycle ghg emissions by 90 and thus close to zero the proposed project amber innovative demonstrator for hybridelectric regional application addresses this aspect and pursues the maturation of hybridelectric key components and the validation of a productrepresentative parallel hybridelectric propulsion system architecture fuel cell based for nextgeneration regional aircraft with eis by 2035 to meet the ambitious environmental goals set out in sria and the clean aviation topic call
enabling and leveraging climate action towards netzero emissions

to implement the paris agreements goals greenhouse gas emissions need to be reduced to netzero around 2050 however current policies are still insufficient to reach this target and netzero promises by countries are generally lacking concrete roadmaps how to reach them elevate aims to create a robust scientific understanding required to strengthen ndcs and current climate policies towards reaching netzero emissions for this elevate brings together a unique multidisciplinary consortium of leading international and national modelling teams climate policy experts and social scientists the consortium aims to interact directly with policymakers to define information gaps and attractive policies thus enhancing usability of the knowledge base and stimulating mutual learning based on this the consortium will systematically assess ndcs and policies at the global and national levels to identify current progress and good practice policies subsequently elevate will look into a range of critical enabling factors related to sectoral action international climate policy and the relationship with justice and sustainable development that can be leveraged to strengthen action this allows a new generation of global and national mitigation scenarios exploring the possibility of strengthening climate policies in countries worldwide and support netzero goals we assess the impact of different ways to formulate netzero goals and the impact of climate uncertainty outcomes include detailed pathways and milestones on how policies can be strengthened to achieving netzero goals elevate goes significantly beyond the stateoftheart by 1 the inclusion of social sciences in all aspects of the analysis providing significantly improved insights into issues related to implementation and feasibility 2 the detailed focus on sectoral action 3 the stakeholder interaction and 4 the direct collaboration between the global and national teams on netzero emission scenarios
quadruplehelixbased knowledge valorisation best practices to transition to an open science innovation management model

kaleidos brings together research and innovation managers and advisors from a group of 4 european universities and one sme with strong competence on knowledge valorisation kv and open science os that will in partnership with a lowintensive kv university collaborate for competence exchange and development crosslearning and skill sharing and network building and consolidation and quadruplehelix qh interactionbased knowledge valorisation best practices kvbp they will share their kvbp and enhance them by embedding actions with qh stakeholders of their local ecosystems throughout all research stages from challenge definition to establishment of multidisciplinary research and innovation teams generation of innovations to respond to existing needs design of project concepts and funding applications and actual project implementation and advancement of results to the market ultimately this process will develop a comprehensive set of social innovation and os approaches and practices to be piloted and assessed within universities and with their ecosystems through a new set of indicators for measuring os and social innovation impact kaleidos will also define with qh actors the os professional profiles for both researchers and managers and the associated capacitybuilding training programmes for universities and research centres generated resources action plans guidelines and peersharing professional network will be made available for any university or research centre to replicate the exercise adapted to their specific context and needs policy recommendations will be developed at national and european level to contribute to the european advancement of the os policy framework ultimately kaleidos aims to consolidate a methodology and associated tools and guidelines to help universities and research centres in their transition towards an os and social innovation management approach at all stages of research
towards a theory of endings in innovation studies

because innovations are important to achieve sustainable development substantial investments have been made in innovation research yet innovations often prove insufficient for replacing established production and consumption practices in endings i argue that we need to overcome this innovation bias by studying how existing sociotechnical systems and their respective knowledge bases end or not in fact evidence suggests that it is more likely for existing systems to endure than to disappear still we have a rather limited understanding of how decline and deinstitutionalization unfold this is an important research gap in several disciplines that needs to be addressed to tackle the transformations needed to achieve a more sustainable society combining theoretical insights from innovation and organization studies in a novel way i will study the epistemic motors of industries by developing an analytical framework that 1 introduces a knowledgebased conceptualization of sociotechnical systems 2 differentiates between different kinds of knowledge and their prevalence in certain industries 3 specifies the ways in which knowledge is maintained and reproduced 4 identifies the mechanisms that lead to the erosion and extinction of knowledge 5 substantiates endings as a precondition for innovation and systemic change to apply this framework i will reformulate the method of innovation biographies by adding the phases of erosion and extinction to the knowledge life cycle and pioneer its application in comparative crosscase analyses of three industries energy ict craft in three geographical contexts germany uk sweden based on the findings i will formulate an original interdisciplinary theory of endings that understands innovation as only one part of the knowledge life cycle such a novel perspective will open new research avenues for empirical analysis that will significantly advance research on innovation and sustainability transitions