Dragon09/odtu_chatbot huggingface dataset:
6g experimental research infrastructure to enable nextgeneration xr services

6g experimental research infrastructure to enable nextgeneration xr services 6gxr will develop an evolvable experimental infrastructure for the duration of the sns programme that covers demonstrating the performance of key b5g6g candidate technologies components and architectures to keep the infrastuctures valid now in midterm and in longterm it will demonstrate technological feasibility of better than 5g kpis innovative radio spectrum technologies and the use and sharing applicable to beyond 5g and 6g spectrum validate a representative endtoend beyond 5g architecture and later 6g including endtoend service provisioning with slicing capabilities and at cloud implementation level open ranfurthermore 6gxr shall validate multi access edge computing scenarios and their integration into a complete cloud continuum support innovative use cases with vertical actors beyond 5g capabilities and support showcasing events in addition 6gxr demonstrates and validates performance of innovative 6g applications with a focus on demanding immersive applications such as holographics digital twins and xrvr 6gxr will support impactful contribution to standards and demonstrate the technological feasibility of key societal requirements and objectives such as energy reduction at both platform and network levels
highly sensitive high spatial resolution high throughput and full elemental mapping simultaneous fsns dplibslaicpms

multielemental mapping allowing the characterization of the elemental distribution in heterogeneous samples at high spatial resolution m scale are opening new applications in many fields as two laser ablationbased techniques laser induced breakdown spectroscopy libs and laser ablation inductively coupled plasma mass spectrometry laicpms are becoming more and more attractive due to the advantages such as rapid sensitive and high spatial resolution mapping especially they are complementary to each other where laicpms offers more sensitive analysis while libs can analyze the elements that are difficult or impossible for laicpms analysis such as h o n c or halogens full elemental fast mapping applications can be achieved with simultaneous libslaicpms technique however due to the different detection mechanisms for these two techniques the optimal laser operation conditions were different where libs typically require higher laser pulse energy than laicpms therefore the libs signal under standard laicpms conditions are generally relatively low in this project to enhance the libs signal without significantly affecting icpms analysis combination of double pulse libs in an orthogonal configuration and laicpms is proposed where a second laser pulse ns is used to reheat the plasma plumeaerosol induced by the first laser ablation pulse fs to carry out highly sensitive high spatial resolution high throughput and full elemental mapping to perform simultaneous optimal analysis by libs and laicpms a highperformance ablation cell with optimized optical collection lenses will be designed and developed further on the analytical setup will be established and corresponding analytical methodology for full elemental imaging will be developed and applied for the real samples such as gemstone the developed dplibslaicpms technique is potential for various filed such as biological mapping and material sciences
digital solutions for accelerated battery testing

the current paradigm for battery testing is fragmented timeconsuming and expensive to fully characterize the performance of a battery cell requires a wide variety of both destructive and nondestructive tests some of which can last for months or years a new paradigm for battery testing is needed that takes full advantage of the latest advances in automation data science and modelling to bring battery development firmly into the digital era digibatt will slingshot the european battery industry forward by developing novel digital approaches to extract more value from fewer tests this will save valuable time and resources in a highly competitive industry digibatt has assembled a consortium representing some of the worlds leading battery research institutions gigafactories and integrators and will apply recent advances in autonomous battery testing modelbased simulation and datadriven semantics to promote digital battery testing from trl 4 to trl 6
the glucocorticoid receptor in aging and circadian endocrinology

the pandemic is stressful for many in response to stress glucocorticoids are released they play essential roles as endogenous hormones and clinically as drugs high levels are associated with cardiometabolic disorders and with aging in contrast diets like caloric restriction ameliorate metabolic dysfunction and prolong lifespan these diets however also increase glucocorticoids now the open question is what are the molecular and physiological effects of increased hormone levels and are these diets beneficial because or in spite of elevated glucocorticoidswe recently found that nutrition reprograms glucocorticoid responses independently of the hormone level and that diurnal glucocorticoid action controls rhythmic gene expression to regulate circulating glucose and triglycerides during day and night i hypothesize that the benefits of caloric restriction are due to higher glucocorticoid amplitudes and that their study will uncover transcriptional features prolonging healthspani propose to functionally distinguish between dietinduced positive and stressinduced negative glucocorticoid responses grace will identify dietspecific rejuvenating transcriptional complexes and target genes versus detrimental pathways triggered by excess glucocorticoids such as stress glucocorticoid receptor targets unique to caloric restriction will be determined via chip and rnaseq in aim 1 the functional impact of diurnal glucocorticoid release will be dissected with a constitutively active receptor allele in aim 2 i propose to map active transcriptional regulomes in caloric restriction in youth and old age by chipms in aim 3 i postulate that enhanced glucocorticoid activity at the right time of day may boost circadian rhythms and promote longevityultimately applying omics to study the molecular mechanisms of stress hormones will identify pathways and genes amenable to pharmacological or nutritional intervention for longer healthier lives
using topology to revolutionize atrial tachycardia treatment

atrial tachycardia at is a prevalent form of supraventricular tachycardia that can have detrimental impacts on a persons health the complexity of anatomical reentry patterns and unclear nomenclature hinders precise diagnosis of at and makes optimal treatment challenging and error prone suboptimal treatment can result in severe outcomes such as heart failure stroke and pacemaker implantation due to overablationinduced atrial dysfunction in this proposal we introduce a diagnostic tool called directed graph mapping dgm which offers a unique classification system based on clear and precise mathematical criteria using topological principles allowing for the accurate diagnosis and differentiation of various types of at dgm can automatically analyze a given case of at providing consistent and reliable results paving the way for the optimization of the ablation strategy dgm can not only diagnose the current at but also predict hidden slower ats which might appear depending on the chosen ablation target by being able to predict the hidden ats we can revolutionize the treatment of ats as these hidden ats can be treated already after the measurement of the first anatomical map therefore our tool holds the potential to significantly expedite the ablation procedure we propose to conduct a prospective study involving a minimum of 15 hospitals in belgium that specialize in at ablations to further validate the effectiveness and sustainability of our proposed solution while involving a broad range of electrophysiologists we aim to publish our results in a highimpact journal we secured the intellectual property rights of our proofofconcept through two patents and by discussing with electrophysiologists we learned that their interest in dgm influences mapping systems if they recognize the value of dgm for treating at mapping companies may adopt the technology through a licensing agreement which is the final goal of this proposal
spatial machinelearning analysis of child indicators

horizon europe seeks to achieve the uns sustainable development goals sdgs the whouniceflancet commission suggests placing children at the center of the sdgs because children are among the worlds most vulnerable and marginalized population child indicators calculated with surveys are limited because surveys can be outdated and do not cover all the regions of a country in this context the objective of the project is to develop a methodology to overcome this limitation and identify vulnerable young children in countries with outdated incomplete and lowquality survey information the methodology is based on a spatial machinelearning analysis of child indicators and integrates 3 disciplines child development spatial analysis of satellite images and machinelearning satellite images and households simulations will complement the missing or outdated information of surveys and machine learning will identify children that could be left behind during the development process due to the intersectionality of gender with biological diversities ethnicity socioeconomic status and geographical location the project will create new tools for monitoring the progress towards the sdgs and will help to formulate targeted interventions that increase the social impact and reduce the economic costs of povertyreduction and development programs if the project is funded dr rolando gonzales martinez will carry out the fellowship at the university of groningen under the supervision of prof dr hinke haisma and with support from prof dr dimitris ballas a short visit to unicef is planned as a secondment for dr gonzales martinez so he can work with unicef on improving the policy impact of the project the transfer of knowledge between the research fellow and the host organization the teaching activities and the short visit to unicef will increase the career prospects and employability of dr gonzales martinez within and outside academia
efficient valorisation of co2 and biowaste for longterm energy storage using a microwave plasma torch and quenching using the reverse boudouard reaction

now that renewable energy generation is already competitive in cost with electricity obtained from fossil fuels the development of efficient long term energy storage methods seems crucial for a faster transition to a netzero greenhouse gas emissions eu economy powertox methods are promising due to their negligible discharge rate but up to now all the efforts have been based on the use of h2 obtained by electrolysis and the teas have shown that the high cost of the electrolysers hinders greatly its possibilities of industrial useeffitorch aims at developing an alternative breakthrough technology for powertox based on the direct splitting of co2 using an ultrahigh temperature thermal plasma with the simultaneous valorisation of low value biowaste leading to the efficient production of syngas effitorch aims to reach carbon efficiencies higher than 90 and energy efficiencies higher than 60 outperforming the best solutions available presentlysome of the research groups in effitorch have a vast experience in co2 splitting using microwave mw plasma torches nevertheless recently a compound approach that combines co2 splitting by thermal plasmas with a quenching using the very endothermic reverse bouduard reaction rbr has been developed in china that vastly improves the promising results obtained in the splitting of co2 while solving one of the yet unresolved issues that of the efficient separation of the gases obtained effitorch aims to explore the possibilities offered by a much improved version of the experimental setups used by the chinese groups including additional sophistications like the ultrasonic atomization of a biooil obtained by hydrothermal liquefaction htl from sewage sludge the use of high temperature reactors with plasma confinement and the implementation of a secondary heating of the plasma by induction with hf frequency 100400 khz that could improve the energy efficiency and reduce costs
reexposure effect in bilinguals under language development rebuildthe acquisition of heritage language in returnee children and mutual effects of experience and cognition

many immigrant children are heritage speakers hss bilinguals who acquire a minority language at home different from the majority societal language in which they are growing up ultimate attainment of the heritage language hl varies considerably amongst individual hssmuch more profoundly that what can be noted in monolingual counterpartsdespite being naturalistic natives from birth understanding what factors explainpredict such differences in hs outcomes is a necessary first step in assessing and ultimately being able to meet the educationalinterventional needs for bilingual hl development reexposure effect in bilinguals under language development rebuild propose a novel approach that combines offline and online methods and focuses on a severely understudied yet crucially important group of heritage speaker bilinguals namely returnees returnees are children of immigrant families who spend a significant portion of their formative developmental years school age in a foreign majority language context a typical hl scenario yet return to their native hl environment often as older children or teenagers this research is important for the global reality in which hl bilingualism proliferates and hl returnees increase yearonyear examining the development of returnees native hl from the point of reexposure to the native environment opens up new directions while research shows that hl bilingualism hlb grammatical outcomes vary significantly findings are largely limited to contexts in which children grow up and stay in an environment where the native hl is a minority language environment transitionsas in the case of returneesopen an exciting opportunity to tease apart internal grammatical structure nonlinguistic cognitive abilities and external factors input use accounting for hlb
noc ima svojo moc the night has its might european researchers night night

engaging local regional and national media an introduction with awareness campaign soil might will bring the project nocmoc nightmight to slovenian and other eu citizens for the fifth timethe core objectives of the project is to raise awareness about the research and its benefits overcome stereotypes stimulate curiosity and excite youth to take up the research careersefficient communication tools successfully used in previous project editions tv radio social media and press conferences will address 1500000 citizens during the project the awareness campaign will explore soil and include 3000 groups families and individuals to participate in citizens science project citizens contribution to the basic research methodology of the real research project will be implemented by use of handson and other research tools in a simple and user friendly mannerprevious editions have developed a growing network of supporting partners in more than 25 cities in slovenia and cooperation with italian ern sharper with which it attracts youth research career paths with eu dimension eventsthe night will bring together over 66 researchrelated institutions raise awareness about research and innovation its relevance to implement the green deal goals its social and economic benefits and enhance a variety of research careers for 100 researchers visiting 140 schoolswe aim for 74000 visitors from different target groups to take part in the nocmoc activities spread all over slovenia over 200 activities science festivals on the main squares of four slovenian cities science shows simulations research and technical days in primary and secondary schools lectures and workshops in public spaces libraries retirement homes museums science espressos steam events eu corners online events and open doors of science research and cultural institutions will attract the audience from dawn to late evening each last friday in september two years in a row
innovative solutions responding to the needs of cities communities

communicity conducts a large number of innovation pilots in many local communities both urban periurban and rural including two eu capitals aiming to empower hardtoreach and marginalized communities it creates three cycles of increasing size building on two dynamic networks of local administrations and living labs of all sizes communicity builds on recent highlighted and awarded european as well as national placebased and locallydriven innovation programmes methods living labs and platforms it brings the learnings of these together and devises an inclusive communitydriven agile innovation and experimentation model with this model it runs a large cocreation process first involving local communities in the challenge definitions then developing innovative solutions through open calls promoted at the european level as well as locally it will create new insights into local community innovation processes as well as principles and models of how to scale these insights in inclusive and sustainably manners in addition communicity will produce a large number of novel innovations anchored in the needs of the local communities and an exemplary approach that is followed throughout europe the core partner cities are already leading and copied smart communities globally because of their diverse approach and ambition to cocreate and share learnings the same goes for the additional four cities and the two networks the aim is to push the frontier of communitydriven innovation much deeper in society and to the margins of society so that the development and testing of novel innovations better serves the needs of the whole society based on european values in the world
structural and mechanistic basis of key intracellular steps of enterovirus infection

enteroviruses evs are positivesense single stranded rna virus from the picornaviridae family with 106 types they can cause mild to severe diseases in human especially children such as common cold rhinovirus myocarditis coxsackievirus b3 cvb3 or poliomyelitis poliovirus pv evs are known to remodel the cytoplasm of host cells to create replication organelles allowing efficient viral genome replication they also hijack the secretory autophagy pathway for replication and viral release recent cryoelectron tomography cryoet work done in the carlson lab has highlight that pv virions directly assemble on replication membrane through a tethering complex where the tether is thought to be viral atpase 2c moreover they were able to show one class of autophagosomes is carrying bundles of filament proteins suspected as filamentous actin factin my project will address two questions in ev replication i how does the viral protein 2c assist membranelocalized assembly ii what is the identity and role of the filaments in virusinduced autophagy i will use an integrative approach of cell biology biochemistry and structural biology and pv and cvb3 will be used as model viruses for this project i first aim to characterize the viral assembly complex by in vitro reconstitution of the interaction between model membranes purified 2c capsid proteins and rna through crosslinking mass spectrometry xlms and cryoet by combining focusionbeam fib milling and cryoet to perform subtomogram averaging i will study the structure of the tethering complex and the one of the filament proteins found in autophagosomes of infected cells in parallel to aid the identification of the filament i will perform proteomic studies through ms study on isolated autophagosomes infected cells finally combined with knockout cells i will be able to identify potential protein candidates and test their effect on ev infection through cryoet and live cell imaging
plastics recycling from and for home appliances toys and textile

as it is addressed by the european plastics strategy european green deal circular economy action plan 20 new methods to reliably calculate verify and report the recycled content in products need to be developed boosting the increase of recycled content in everyday products against the use of virgin materials however measuring the recycled content is complex requiring product tracing to the production source precycling aims to develop an easytouse methodology for sorting sampling tracing and recycling plastic waste streams including detection and separation of legacy additives along with standard analysis procedures for both plastic waste materials and recyclates secondary raw materials in order to produce consistently high quality safetouse recyclates based on their degradation degree and addedvalue products with predicted lifetime smart tracing via digital systems will be developed in parallel to ensure the quality and safety of reused materials targeting a sustainable transparent and functional circular economy model for the recycling market the environmental and financial viability of precycling solutions will be assessed throughout life cycle and cost analysis in order to reach competitive prices of recycled products the above will be demonstrated producing i home appliances components ii toyslearning resources and iii 100 recycled textile starting from the same sector recyclates and different european regions however the proposed methodology in precycling could be adapted by many other sectors ie packaging vehicles and electricelectronic equipment triggering significant societal impact apart from commercial and industrial interest demonstration activities will serve as part of a community awareness initiative showing that from waste to product transformation is scalable replicable traceable commercially viable and most importantly safe to use both within the same and new supply chain products
healthy or harmful distrust on the democratic relevance of political scepticism over blind distrust

paradoxically representative democracy requires not only citizens trust in the institutions of democracy but also a healthy dose of political scepticism towards these institutions scholars have warned against the detrimental effects of blind trust and blind distrust the former would make citizens susceptible to manipulation the latter to alienation by contrast distrust that is not blind but evaluative stimulates vigilant civic engagement while blind distrust would lead to an anomic democracy evaluative distrust would stimulate democratic reinvigoration and accountabilitywe should therefore not merely distinguish between political trust and distrust but also between dispositionalblind and evaluative distrusthowever empirical studies of political trust focus almost exclusively on the level of trust the standard political trust survey items cannot distinguish blind distrust from evaluative distrust this vast lacuna at the heart of political trust research left the major questions in the field unanswered on the trends causes and consequences of political trustcriticaltrust addresses this fundamental problem it first develops a novel twodimensional model of political distrust and creates new measures that distinguish blind from evaluative distrust this model and these measures will be the foundation for primary data collection largen survey experiments the survey is designed as a threewave crossnational panel survey in 8 european countries estonia france germany hungary the netherlands portugal sweden and the united kingdom both the surveys panel element and the experiments allow us to systematically test causal effects that have long been proposed in the literaturecriticaltrust thereby answers questions that plagued political trust research for decades it will offer diagnoses of the risks of low and declining trust and advice to democratic actors whether and how to stimulate political trust