Dragon09/odtu_chatbot huggingface dataset:
enantioenriched carboxylic acids from alkyl boronic esters through copper catalyzed co2 fixation

co2pper aims to explore a comprehensive method for the underinvestigated catalytic co2 fixation in asymmetric carboxylation reactions to produce chiral carboxylic acids unlike traditional methods that rely on asymmetric hydrogenation of unsaturated acids and hydroxycarbonylation of alkenes catalytic co2 fixation provides a direct and environmentally preferable alternative despite recent efforts in creating new chiral ligands to manage reactivity and selectivity developing a universal catalytic carboxylation using co2 remains an unsolved problem co2pper proposes a novel approach by employing stable and easily accessible sterodefined alkylboronic esters in metalcatalyzed carboxylations to prepare a broad range of enantioenriched chiral carboxylic acids the co2 insertion will be achieved by the use of abundant and inexpensive coppercatalysts taking advantage of the lowest energy barrier for co2 insertion into a mc bond this project will significantly contribute to the advancement of the co2valorization framework and presents an innovative green methodology for chiral carboxylic acid synthesis
investment migration patterns natures and trends

foreign direct investment fdi flows are conducted by individual investors abbreviated as ifdi which have been strongly promoted by immigrant investor programs iips twentyone out of twentyseven of the member states of the european union eu establish iips to attract wealthy investors in order to receive investment capital change the economic structure and social status of undeveloped regions make a name for the country on the international market and as an economic diplomacy strategy while the fdi motivations of enterprises have been extensively studied the motives of ifdi remain undeveloped this limitation is certainly a missing puzzle piece in the scientific world causing a lack of a theoretical basis to explain a real phenomenon simultaneously demandside motive ambiguity might impact the design of iips leading to their inefficiency governments also lack a base to take a consistent stance on ifdi this proposal aspires to provide a scientific and practical basis to fully understand the variation of ifdi thereby aligning policy with its evolution the overall aim is to develop the patterns of ifdi its nature and trends qualitative research methods with a variety of tools mainly based on naturally occurring data associated with the opinions of the participants knowledge coproducers two theoretical frameworks are developed ims12 to identify the drivers and nature of ifdi and vira to forecast ifdi the results of this project in addition to fulfilling its own objectives will also serve as the foundation for further research in several scientific fields such as economics sociology and politicsthis project is expected to run for 24 months and is hosted by the university of malta in malta including a 4month secondment at the university of graz austria
flexible energy systems leveraging the optimal integration of evs deployment wave

flow boosts and demonstrates multifaceted ev smart charging and v2x integration into energy systems thanks to a range of comprehensive solutions providing answers to the needs of all actors involved these solutions include highly replicable usercentric products concepts configurations and mechanisms to optimise operation crosssector harmonisation and standardisation is delivered to facilitate activities of stakeholders and ev users advanced interoperable solutions enhance planning operation and assessment of ev charging for seamless integration into the energy system and identification of the most appropriate scenario based on a multicriteria model leveraging appropriate business models and tailored services flow also delivers multiactor orchestration to ensure data exchange and synchronisation across actors for vgi and ev flexibility services these solutions are deployed in 5 demonstrations including 2 testbeds and 3 largescale demos in cz ie it dk and es covering a wide range of applications eg v1gv2bv2hv2g publicprivatesemipublic urbanruraltouristic carsmall medium commercial to validate and quantify the benefits associated with enabling and valorising ev flexibility alleviating grid challenges and fostering mobility and energy decarbonization expected impacts include ghg emission reduction of 06mtco2y grid reinforcement saving up to 13bcountry increase local res by 14 and avoid res curtailment by 4twh the consortium includes 26 partners from 9 european countries covering the entire value chain including oem technology providers cpos aggregators dsos tso ict developers rtos experts in users mobility harmonisation optimisation tools energy integration and leveraging the networks of umbrella associations from the electromobility and the dsos these ensure replicability and scalability to foster the ev penetration trends thanks also to comprehensive communication dissemination and exploitation actions
developing broadspectrum antiviral drugs for pandemic preparedness

antiviral drugs will be key in the management of future virus outbreaks for each virus family with epidemicpandemic potential stockpiles of potent drugs are needed that can be deployed when a new pathogen emerges such broaderacting drugs targeting conserved viral functions are needed as of day one of an outbreak for treatment and prophylaxis eg in hcw and frail patients in combination with quarantine measures such drugs will delay global spread allowing time for vaccinedevelopment since the 2003 sars outbreak panvipreps core partners have successfully collaborated in leading european antiviral drug research projects this provides a solid scientific basis in combination with translational drug discovery expertise the team includes virologists biochemists structural biologists medicinal chemists and pharmacokinetics experts previously developed knowhow and toolboxes will be a major asset to achieve immediate impact panviprep aims to greatly expand the antiviral portfolio and identify novel druggable targets of highrisk rna viruses hits will be identified through i phenotypic antiviral screening of compound libraries ii structurebased drug design iii in silico screening supported by the latest machinelearning methods we will deliver 25 to 50 highquality broaderspectrum pangenuspanfamily hit moleculeshit series two of these will be developed to the early lead stage including proof of concept in animal infection models remaining hits will serve as chemical toolcompounds to explore mechanisms of action thereby identifying novel druggable targets in rna virus replication this in turn will accelerate targetbased drug design efforts the workflow will integrate best practices in antiviral drug discovery with a range of methodological innovations including aibased methods thus renovating and accelerating the antiviral hit discovery pipeline future use and contributing to pandemic preparedness
gravitational waves from strings with adaptive mesh refinement

cosmic strings are motivated by simple extensions to the standard model of particle physics bsm including dark matter axion models axion cosmology superstring theory and grand unified theories if present cosmic strings will radiate gravitational waves gws which could be detected by current and future gw experiments such as ligovirgokagra lvk lisa and the einstein telescope detection or bounds placed on cosmic strings provide deep insight into bsm particle physics models and are a potential discovery channel for new fundamental fieldssearches for cosmic strings in lvk data have to date used analytic waveforms predicted using the nambugoto ng approximation this is problematic as the ng model is known to be inaccurate in precisely the highcurvature regions from which the strongest gw signals are emitted these waveforms have never been verified by numerical simulation so current matched template searches may not provide useful information or constraints gwstrings will address this by producing the first waveforms for cosmic string cusp configurations in full numerical relativity nr and using them to perform a matched template search in the lvk data gwstrings will also match these waveforms to current analytic models to determine their validity simulations will be implemented using the adaptive mesh refinement amr nr code grchombogwstrings will require crucial input from researchers in two key areas theoretical understanding of fundamental fields in the strong gravity regime and gw source modelling and data analysis the first will be provided through a secondment at sapienza university of rome in the worldleading gravity theory group of prof paulo pani the second will be provided by grappa the host institute whose foundational focus lies in connecting astroparticle physics gravitational physics and cosmology where the project supervisor prof samaya nissanke an internationallyrecognised gw data analysis expert
intrinsic microenvironmentdependent potentiation of antibodies for cancer therapy

the principal goal of this proofofconcept study is to explore the feasibility of a cofactorinduced oligomerisation of igg to potentiate the therapeutic efficacy of anticancer antibodies targeting the tumour site our idea is based on two phenomena firstly in our previous studies on the interaction of heme with therapeutic antibodies we found that the interaction of trastuzumab with heme results in the formation of wellorganized oligomers through fabfab interactions of two igg molecules these species were considerably more potent in activating the complement system and inducing killing of cancer cells importantly we were able to transfer the potential for oligomeriszation mediated by heme on two unrelated monoclonal antibodies used in clinical practice thus providing strong evidence of the feasibility of the engineering effort and the utility of its application for broad range of igg molecules secondly there is strong evidence in the literature about the ability of tumours especially malignant to provoke haemorrhages based on these two phenomena we formulated our working hypothesis that the locally released heme and hemoproteins at tumour sites can be harnessed as trigger of oligomerization of engineered igg molecules thus increasing their proinflammatory and cytotoxic activities due to aggregation of the fc portion in close proximity this will result in higher antibody avidity more efficient crosslinking of fcgamma receptors better recruitment of complement proteins c1q and hence a stronger activation of the immune effector cells and the classical pathway of complement system on the surface of cancer cells successful accomplishment of this project will have considerable societal impact due to clinical and social significance of cancer
loop corrections from the theory of motives

the interactions between the elementary particles are encoded into a set of mathematical quantities called scattering amplitudes consequently they are key to making predictions for physical observables that match the precision achieved by current and future highenergy experiments due to our ignore of the mathematics involved computing loop quantum corrections to scattering amplitudes is still a major challenge today and calls for innovative and groundbreaking new techniquesover the last decade a new field of research that studies scattering amplitudes through the lens of a certain branch of modern mathematics the socalled theory of motives has led to breakthroughs in how we compute loop quantum corrections locomotive will bring the connection between scattering amplitudes and modern mathematics to the next level it will investigate in detail what the theory of motives teaches us about the structure of scattering amplitudes its final aim is to achieve a global change of perspective on the mathematical underpinnings of the laws of nature and develop novel computational techniques for scattering amplitudes that are currently beyond reach of conventional stateoftheart technology inspired by cuttingedge research in seeminglydisconnected areas in mathematics and physics locomotive will 1 perform the computations needed to reveal how concepts from geometry govern the fundamental interactions2 play a decisive role in providing the theoretical predictions needed for the lhc and future collider experiments 3 act as a catalyser for new research in mathematicsto sum up locomotive is a timely proposal with a unique multidisciplinary character whose results will bridge a gap between formal theory and concrete phenomenological results it will have a major impact on formal aspects of quantum field theory and possibly even pure mathematics and provide highlyneeded theoretical predictions for the lhc experiments
retrofit solutions to achieve 55 ghg reduction by 2030

the proposal develops a combination of energysaving solutions that can be adopted in retrofitting aimed at achieving the 35 of ghg emissions two new technologies ie wind assisted ship propulsion and an innovative air lubrication system will be developed together with other solutions that although based on already mature technologies such as operational and hydrodynamic design optimization and ship electrification have to be expanded to be integrated with the new solutions as well as to cope with the constraints posed by the original ship design the final objective of retrofit55 is to create an advanced webbased decision support system dss that fuses together digital twins of the different systems into an integrated digital ship model the dss will feature a catalogue of retrofitting solutions that are uptodate and ready to be deployed at the end of the project and easily extendable afterward while developed and demonstrated at trl 78 suitable for different ship types and operational contexts the dss will enable the user to configure the retrofitting by combining different options which are suitable for the specific ship type and comparing them in terms of lifecycle cost returnofinvestment and several kpis such as eexi cii referring to the zewt strategy while primarily contributing to the design and retrofit the implementation of the project will also intersect other topics such as use of sustainable alternative fuels energy efficiency electrification and digital greenthe consortium brings together universities and research institutions three developers of the new technologies a ship design office software developers ict experts a classification society a shiprepair company and two large ship operators
accurate reliable portable and rapid methods and technologies for detection of ghb substances and prevention against different forms of violence and assault supported by these drugs

armadillo aims to equip law enforcement authorities leas and more particularly police authorities and forensic institutes with a holistic groundbreaking easytouse portable toolset that rapidly detects ghb concentrations in urine saliva and beverages to realize this the project will focus on the design and development of insitu ghb detection systems integrating advanced optical spectroscopy and electrochemical techniques for precise ghb identification in the different matrices both optical and electrochemical detection techniques will be integrated to portable readers capable of quantitative ghb onsite determination the optical spectroscopy techniques will explore surfaceenhanced signalbased approaches raman and fluorescence alongside paper strip methods while electrochemical detection will combine a specialized fluidics module and nadnadh electrodes in parallel ghbspecific antibodies will be developed aiming to further enhance its detection selectivity and accuracy the project will prioritize the enhanced collection and sharing of forensic evidence emphasizing on forensics data management and ensuring interoperability and harmonization across systems by integrating data fusion mechanisms it will provide reliable safe and courtproof forensic evidence while also leveraging the potential of ai for refined raman analysis concurrently it will undertake a comprehensive risk assessment to bolster prevention strategies against drugfacilitated violence and assault all while standardizing user interfaces and employing advanced visualization and reporting techniques in order to avoid clinical trials and comply with the ethical considerations including the privacy and safety of any involved human subject armadillo will assess the accuracy sensitivity and specificity of its sensing technologies using synthetic samples that simulate a wide range of ghb concentrations in urine and saliva samples
reconnect china generating independent knowledge for a resilient future with china for europe and its citizens

in the modern geopolitical world the eu and china stand in a constant dynamic relation with each other the question in which domains eu collaboration with china is desirable possible or impossible is therefore the central focus of reconnect china to answer this question this project identifies science technology economy trade domestic governance and foreign policy as four key fields on which the eu should upgrade its independent knowledge to that aim it will develop a database which will provide access to new sources of information the independent knowledge generated in this project will bring together stakeholders and experts in a europechina knowledge forum and raise awareness on china among the general public and youth in this way leading scientific european expertise and innovative digital technologies are mobilized to generate a deeper sustainable understanding of contemporary china and work towards a resilient future with china for the eu and its citizens
highspeed organic photonics and optoelecronics

hisope addresses the fundamental scientific and technological challenges for the decarbonization of the digital society by focusing on novel fast and broadband organic optoelectronic materials devices and systems allowing high addedvalue applications such as optical data transmission and wireless optical communication more precisely hisope aims to develop organic semiconductor osc materials and fabricate different organic devices like highspeed organic light emitting diodes highspeed organic photodetectors and electrically driven short pulse organic lasers and integrate these into labscale waveguided and wireless data transmission demonstratorshisope is fully in line with the european semiconductor chips act and european industrial autonomy endeavors because it chooses to provide osc based solutions for highspeed optoelectronics and photonics instead of often toxic and critical material dependent iiiv semiconductors this will help to diversify and strengthen the european digital and optical telecommunication industrial ecosystem through the emergence of new industrial actorshisope tackles the issues of responsible and sustainable electronics head on by following 4 paths to sustainability 1 the avoidance of toxic and critical raw materials such as iiiv semiconductors 2 the reduction of carbon and embedded carbon footprint 3 device and system design that takes recycling into account from the outset 4 the mass reduction of materials substrates and encapsulation also hisope has a clear vision of a road to industrialization that includes several wellidentified market alternatives for organic optoelectronics and photonics to maximise the chances of reaching the industrial stage for this project several markets and use cases are proposed in the work package labscale proof of concept dissemination and exploitation we will identify the ones most likely to succeed commercially and take steps to maximise impact from the project
exploring tipping points and their impacts using earth system models

tipesm brings together scientists from a range of disciplines to deliver a step change in our understanding of climate tipping points in the earth system including their impact on ecosystems and society combined with a set of early warning indicators and safe future emission pathways that minimise the risk of exceeding such tipping points tipesm assembles the latest earth system models esms including recent improvements to key processes ice sheets vegetation and land use permafrost marine and terrestrial biogeochemistry in cooperation with the wcrpfutureearth project tipmip tipesm will organise an international collaboration to design and realise a common esm experiment protocol that will facilitate analysis of the likelihood of occurrence and potential reversibility of tipping elements at different levels and duration of global warming these experiments will be combined with more projectspecific esm experiments designed to investigate interactions and feedbacks across the earth system based on the tipesm experiments existing simulations and observations we will investigate tipping points their driving processes potential early warning signals and cascading effects across the climate ecosystems and society including the most important components of the earth system in our esms will also allow tipesm to identify potentially unknown tipping elements their precursors and impactstipesm brings together expertise from climate science and climate impacts to investigate both the role of gradual climate change for tipping in individual ecosystems and society and the impact of crossing specific climate tipping points for society ecosystems and biodiversity project findings will be synthesised into a tipping points risk register new knowledge and data from tipesm will be regularly communicated to a broad range of research communities policymakers and the public contributing to a prepared and resilient society
advancing subseasonal predictions at reduced computational effort

the new frontier for weather prediction is the socalled subseasonal time scale of two weeks to two months ahead to take preventive measures at an early stage reliable forecasts on this time scale are becoming increasingly important for multiple socioeconomic sectors subseasonal predictability can be gained from recurring patterns in the earth system aspire will focus on one of these namely modes of tropical convective variability longstanding systematic errors due to the parametrization of processes in numerical weather prediction models prevent the predictability of these modes from being exploited simply running models at a resolution high enough to resolve tropical convection is not feasible due to high computational costs taking advantage of three recent developments aspire will explore new ways to better exploit the intrinsic predictability of tropical convective modes without exhausting the currently available computing resourcesthe uniqueness of aspire is its crossdisciplinary approach that builds on my experience in atmospheric dynamics and predictability numerical modeling and machine learning ml first aspire will identify the source regions and pathways of tropical forecast errors that prevent the intrinsic predictability from being exploited using a new set of subseasonal ensemble hindcasts second aspire will quantify for the first time the added value of locally confined kilometerscale resolution in the source regions identified before and generate probabilistic predictions from deterministic forecasts through mlbased postprocessing third to enable simulations at kilometerscale resolution in operations aspire will develop ml approaches that emulate the integrated effect of the resolved convection in the tropics at substantially reduced costs if successful this approach would be a breakthrough towards improved operational weather forecasts at substantially lower computational costs for a global socioeconomic benefit