Dragon09/odtu_chatbot huggingface dataset:
programmable active matter

living systems employ cliving systems employ chemical energy to generate mechanical forces and motion often resulting in emergent phase transitions that manifest as various spatiotemporal structures this inherent behavior makes living systems ideal subjects for the study of nonequilibrium thermodynamics yet their complexity impedes our current experimental control of their phase transitions we propose a novel simple and quantitative experimental system to study phase transitions of living matter in a controlled nonequilibrium environment we create an innovative invitro active system using biological components linking a microtubule motile network to gene circuits that control the system through the local synthesis of building blocks this will allow us to program the constituents interactions type range strength position and the mechanical properties of the carrying media we offer to study dynamical phase transitions from two perspectives 1 internally driven nonequilibrium phase transitions defined by dynamical or nonreciprocal interactions 2 thermal transitions occurring within a nonequilibrium environment we will establish this system by studying microtubules active flow hydrodynamics and pattern formation driven by gene circuits aim 1 we will also program local interactions that defy newtons third law and study their emergent collective dynamics aim 2 lastly study phase transition of thermal deformable soft objects mechanically interacting with microtubules flows aim 3 our innovative approach will yield tools and insights for understanding biomaterial selforganization with broad relevance it has the potential in the field of physics to lead to the discovery of novel phase transitions and explain them quantitatively in biology it helps uncover the mechanisms behind cell shape maintenance and motility regulation moreover it holds promise for industrial applications enabling precise transport control within closed reactors
sustainable technological accessible and resilient humancentric manufacturing supporting the new european bauhaus through synergies between customized production and consumption models

starhaus has moving from the diy4u project h2020 starhaus will design test and validate 8 new hardware module prototypes for the existing diy4u manufacturing demonstration facilities mdfs to manufacture newly designed products for personalized fastmoving consumer goods the project will focus on 4 new usecases pet food fertilizers beverage breakfast cereals starhaus will adapt technologies and design new services and processes in an interdisciplinary approach that involves human centered design social science impact and indicators full technology cycle hardware software creativity and arts circularity and sustainability the focus will be on sustainability and circularity enabling the growth of efficient effective sustainable and stakeholderaligned manufacturing methods through reuse adapt redesign and repurpose existing technologies as a value for the larger community the project will be inspired by the new european bauhaus paying particular attention to regenerative design and regenerative and valueadded manufacturing and adopting a humancentric and participatory approach with contributions from social sciences and humanities ssh the project will promote collaborative models between domain experts artists and technology providers improved access to flexible production capabilities in decentralised environments especially for smes will be ensured by fstp and accurate promotion of collaborative models with domain experts artists and technology providers the starhaus approach will leverage creativity in interdisciplinary and artistic disciplines and offer a process model towards viable solutions starhaus is focusing on delivering an impact inside modern consumer communities to propagate behavioral and technological changes that can reshape our lives the consumption habits of modern consumers must change to adopt healthy and sustainable solutions that can be achieved at affordable prices without compromising quality
sustainable materials for innovative low emissions applications in the circular city

smile city provides realistic circular systemic solutions to support the evolution towards a carbonneutral environmentally sustainable toxicfree circular economy by 2050 the contribution to c02 reduction works on two levels an intensive use of recycled materials in replacement of virgin ones without decreasing the performance of final products the use of such products and applications to increase sustainable mobilitythe project aims to integrate innovative systemic solutions in up to 100 km of cycling paths and implement 20 ebike charging stations developed using different types of recycled urban waste construction materials eol tyres and eol batteries from electric vehicles the foreseen innovations include the creation of ebike charging stations made of recycled concrete precast elements and pv panels equally produced with recycled materials the installation of recycled rubber moulded products for urban furniture such as rubber bollard lane dividers and rubberized asphalt which contributes both to increase sustainability and safetysmile city will thus assemble the technological state of the art of the different value chains involved to implement circular systemic solutions in 7 different eu and noneu countries backing the transition towards a regenerative inclusive and circular economy at local and regional scale across europe and therefore boosting interregional and crossborder cooperationin addition the project will also increase resource efficiency reinforcing europes strategic autonomy and reduce the negative environmental footprint related to current recycling techniques of the considered urban waste value chains by supporting awareness raising and information spreading smile city will engage both citizens and industrial leaders in the green transition towards climateneutral solutions for circular cities bolstering the market uptake of circular solutions through regional and local actions two partners are ccri members
photoswitchable ultrathin membranes for molecular separation

the separation of molecules and ions by membranes is essential for the separation of gases purification of water energy conversionand storage and many other applications and is therefore of crucial technological importance for achieving the sustainable development goals clean water and sanitation affordable and clean energy and climate action defined by the un the membranes established to date suffer either from a poor compromise between permeability and selectivity or from fouling innovative concepts to extend the lifetime of membranes and to improve their separation performance are urgently needed to achieve the aforementioned goals as quickly as possiblephotobrane will train a new generation of leading experts in a completely new approach to membrane technology to take separation performance and longevity to a new level our research will be built on the most modern membrane materials investigated by photobranes pis in our new research approach we are exploring how to use photochemistry methods to develop photoswitching regimes of the membranes wettability to prevent their fouling to achieve unprecedented separation performance we take the photoswitching a step further and investigate the influence of phototuning the structure porosity and polarity of dyeloaded membranes on their function in gaseous and liquid media through this research the doctoral researchers receive interdisciplinary training and through secondments to industrial partners gain insights into various topics of photo and material chemistry as well as membrane technology the excellent research is carried out at renowned european centers of membrane research and photochemistry the mobility within the network combined with excellent research and training creates a highly synergistic framework for success this ensures an efficient transfer of excellent academic results to industry through a new generation of entrepreneurial and highly skilled scientists
an ai ondemand platform to support research excellence in europe

europe is implementing an ai strategy that seeks to create a research environment characterised by scientific excellence and consistent with the fundamental ethical values of its citizens part of this strategy foresees the consolidation of ongoing research activities through the creation and maintenance of an ai ondemand platform that will act as a community resource for the research community facilitating experimentation knowledge sharing and the development of stateoftheart solutions and technologies ai4europe builds on the work of ai4eu and multiple supporting projects ict48ict49 creating an open impartial and collaborative platform built by the european research community according to their needs equipped with the necessary hardware the platform will offer interoperable services data and tools from several related communities and provide solutions to facilitate research productivity reproducibility and collaboration ai4europe will establish and support mechanisms to foster exchange between academia and industry and ensure the platform reaches out to and engages with the next generation of researchers and those in widening countries the project will develop and implement a business model that will ensure the longterm technical and financial structures providing sustainability for the platform beyond the lifetime of the project ai4europe will support the community to create a tool that will help position europe as the place where the very best ai research is conducted
new solutions for hydropower plants to enhance operational range performance and improve environmental impact

currently hydraulic turbines are employed across a broad spectrum of operational regimes a particular case is represented by the environmental flow eflows which are essential for the conservation of fluvial ecosystems but often force to operate out of design parameters or rather switch off the plants on the other hand the impact of hpps on water quality and biodiversity up and downstream is enormous and should also be a target for refurbishing actions in this context the sherpa project will develop and validate innovative technologies for refurbishing current hpps namely 1 am metallic patches and coatings to minimize damage and enhance resistance to cavitation 2 new strategies to adapt rotational speed depending on the flow range 3 advanced air injection systems to improve water quality and efficiency 4 new runner designs adapted to eflows increasing performance modelling simulation and monitoring tools will assess the new solutions of the in terms of energy output flexible operation costeffectiveness and impact on biodiversity the goal is to expand andor adapt the operational range of the hpp to include lower flows without this harming their lifetime economic viability and environmental and social impact in order to meet this objective the project proposes a methodology comprising 8 work packages groups in four blocks to be carried out during 42 monthssherpa has a wellbalanced consortium with 7 partners from 4 countries covering all the competences and knowhow in terms of expertise resources and positioning in the field which will ensure the achievement of the project objectives and make an impact at european level
protecting the thymic epithelial cells and thymopoiesis during hematopoietic stem cell transplantation

allogeneic hematopoietic stem cell transplantation allohsct is a common often lastresort treatment for haematological diseases but it is plagued by longterm morbidity and high mortality direct allohsctinduced damage to the thymus and subsequent loss of thymopoiesis ie the production of new t cells is considered one of the main reasons for these complications our limited understanding of how the thymus is damaged during allohsct restricts the development of thymusprotecting protocols the goal of protecthy is to unravel the intrinsic protective mechanisms of the human thymus and assess how allohsct affects them with the ultimate objective of devising measures to prevent thymic damage we take advantage of an innovative whole organ culture system for the human thymus developed in my laboratory and our extensive preexisting collection of human thymus tissue samples spanning a diverse age range protecthy specifically aims to 1 discover how the thymus protects itself from external insults over the course of the human lifetime 2 reveal how allohsct disrupts the human thymus microanatomy and how that damage can be prevented with a cellular therapy and 3 examine how thymic damage affects the circulating true naive t cells and if existing clinical treatments for allohsct complications can restore the loss of thymopoiesis we will apply stateoftheart spatial and singlecell multiomics to dissect these protective layers of the thymus both ex vivo and after alloreactive challenge in vitro moreover by testing the effect of treatments already in clinical use protecthy can resolve their specific mechanisms of action and impact on the thymus our results are thus directly translatable to the human condition and can direct future treatments to enhance outcomes following allohsct as a translational immunologist and clinical microbiologist with extensive experience in human thymus research i am well equipped to uncover the mechanisms of thymic protection
bottomup reconstruction of a synthetic erythrocyte

blood is a precious and vital resource for many clinical interventions erythrocytes its key component are used to save thousands of lives every day worldwide yet in low and middleincome countries its scarcity and unsafe control are endemic burdens that cost lives in spite of several decades of attempts to develop a safe and universal blood substitute this goal has yet to be achieved beyond the mere transport of gasses erythrocytes have evolved together with their host organisms to perform very specialized functions it is now clear that much of their complexity is indispensable to establish effective cardiovascular regulation yet reproducing this complexity in a synthetic functional facsimile is a challenging endeavour that requires new methods and multidisciplinary approaches the ambitious goal of synery is to reproduce in an advanced lipid vesicle the following key features of erythrocytes adequate lipid asymmetry with raftlike nanodomains integration of essential functional proteins both cytosolic and transmembrane and a biomimetic cytoskeleton conferring durability flexibility and biconcavity enhanced immune tolerability responsivity to environmental cues such as under deformation and hypoxia these goals will be tackled by an interdisciplinary consortium bringing expertise on dropletbased microfluidics combined with interfacial selfassembly of biofunctionalized nanoparticles to build complex biomimetic membranes with ordered cytoskeletal nanodomains dna origami and selfassembling peptide technologies to reconstruct a biomimetic cell cortex and invivo testing models to verify biocompatibility and functionality the knowledge gained by producing a synthetic erythrocyte is envisioned to enable the production of artificial cells with invivo applicability and it will pave the way towards the future development of an effective blood substitute that can remedy pervasive global blood availability and safety issues
polartomidlatitude climate linkage effects on cold air outbreaks

cold air outbreaks are a typical feature of the midlatitude climate during the cold season their relevance relies on the threat to life caused by the longlasting periods with abnormally low temperatures as well as on the potential of damage to crops and the occurrence of highimpact weather events such as heavy snow and low visibility during blizzards previous studies have documented the linkages between climate variability at high latitudes with that at midlatitudes mainly through modulation of the storm tracks jet streams and patterns of stationary waves which promote blocking events the role of other components of the climate system like sea ice is much less understood and remains an open question this becomes even more challenging under the current conditions of fast sea ice reduction in the arctic and the significant trends observed in sea ice around antarctica which leads to an increase in uncertainty in the area of subseasonal to interannual climate predictions as well as for climate projections for the coming decades furthermore significant biases currently exist in the representation of sea ice in stateoftheart climate model simulationsthe main objective of this proposal is to analyze the physical mechanisms linking variability at high latitudes including that of sea ice with climate variability at midlatitudes special focus will be driven onto the mechanisms promoting cold snaps at midlatitudes and on their variability to this aim this project will make use of a data set of veryhighresolution coupled global climate model simulations at around 10 km which is expected to bring significant improvements to the representation of sea ice as well as to its linkages with other components of the climate system outcomes of this project are expected to become useful for decision makers and stakeholders as well as to researchers working in the field of climate predictions and projections
decoding epistatic genomernome interactions in eukaryotic fitness gain using leishmania parasites as a unique model system

darwinian evolution plays a central yet poorly understood role in human disease iterations between genetic mutation and environmental selection drive cancer development microbial infection and therapeutic failure thus increasing human mortality the molecular mechanisms that harness the deleterious effects of genome instability to generate beneficial phenotypes in these pathogenic systems are unknown here we investigate this important unsolved question in the protozoan parasite leishmania that causes devastating human infections in the absence of transcriptional regulation these earlybranching eukaryotes exploit genome instability to regulate expression by gene dosage leishmania thus represents an ideal system to investigate how genome instability drives fitness gain in fast evolving eukaryotic cells such as observed during cancer development synergizing our expertise in genomics evolution systems and rna biology we have recently made several breakthrough discoveries that link parasite fitness gain to epistatic interactions between coamplifying genes of small noncoding rnas which program epitranscriptomic and translational regulation we hypothesize that these genomernome interactions generate the phenotypic landscape underlying leishmania fitness gain our proposal investigates this groundbreaking concept through two specific aims that i combine experimental parasite differentiation and evolution in vitro and in vivo to reveal molecular mechanisms underlying leishmania predictive adaptation and fitness gain and ii investigate how rna modification and noncoding rnas contribute to adaptation by regulating mrna stability and translational control our findings will be highly relevant to other fast growing eukaryotic systems that rely on genome instability such as cancer or fungal pathogens
humour as an epistemic practice of the political present

something weird is happening in politics satirical parties comedic journalism and memeification are gaining more and more traction the slippages between parody and sincerity play and earnestness real and fake ridicule and seriousness have proliferated at a dizzying rate global entanglements new technologies and the surge in populist politics are producing a cacophony of intricate cognitive social and economic dissonances bordering on the absurd the underlying hypothesis of nojoke is that these dissonances and the comical reactions produce have become formative phenomena of the political present they have seeped into the social fabric and into the ways in which people appropriate their lifeworlds and make sense of themselves and others as political actorsthe practice of humour nojoke argues can help us to make sense of the political present it offers a unique methodology of discovery a specific education by attention with regards to dissonances that elude conventional academic methods bringing together insights from the anthropology of politics and the political from studies on humour satire and laughter and from anthropological advances in ontology epistemology and methodology nojoke will conduct research with humour and humourists and not merely on them and establish a radically new approach to the study of the political present through a longterm comparative study with caricaturists comedians writers of satire satirical politicians and comedic journalists in berlin brussels budapest caracas johannesburg and the iranian diaspora it will follow three objectives 1 to explore the intrusion of humour and humourists into the field of politics 2 to articulate a theory of humour as an epistemic practice a mode of perception creation and anticipation in and of the political present 3 to launch an alternative practice of academic knowledge production by converting the heuristic of punchlines into a practice of theory
tidal disruption events a new black hole census

massive black holes mbhs are key players in high energy astrophysics galaxy formation and evolution and astroparticle physics despite their centrality to astronomy we still cannot answer basic questions about mbhs what are their origins how have they grown over cosmic time what are their current demographics to answer these questions the project will turn tidal disruption events tdes from curiosities into reliable probes of mbh parameters a tde occurs when an unlucky star passes too close to a mbh and is ripped apart by tidal forces the ensuing fallback of debris powers a highly luminous potentially multimessenger flare tdes are in principle ideal probes of mbh properties unlike standard techniques for measuring mbhs tdes i happen in all galaxies ii are visible to cosmological distances and iii involve very few free parameters but the theoretical picture of tdes remains confused as the large dynamic range of tdes has prevented ab initio simulations to determine how tidal debris evolves and radiates at present there is no consensus on the geometry or even the power source of observed tde flares making robust parameter estimation impossible i will solve these open theoretical questions capitalizing on my recent pilot study that for the first time ever simulated a typical firstprinciples tdethis project will deliver a firstprinciples simulations of the evolution and emission of tdes b idealized but accurate models of tde light curves and spectra suitable for parameter estimation c a firstever sample of mbh parameters derived from fitting ab initio models to tde observations i will use these results to sidestep the limitations of other mbh measurement techniques and to place unique constraints on the formation and growth history of the smallest mbhs this work is urgently needed in light of upcoming allsky surveys such as ultrasat and lsst which will expand the tde sample from dozens to thousands in the mid2020s