Dragon09/odtu_chatbot huggingface dataset:
design of metalstabilized dna and rna nanoconstructs potentially applicable in medicine

dna nanotechnology can provide breakthroughs in various fields such as catalysis nanofabrication computation bioimaging drug delivery or cancer treatment this approach is based on the idea that if singlestranded dna sequences are not perfectly complementary branchedstranded dnas can be formed from which complex 2d or 3d structures can be constructed with nearatomic precision by proper sequence design although dna nanomaterials seem to be promising the biomedical application is significantly challenged by the fact that current dna and especially rna nanostructures are unstable under physiological conditions sensitive towards nucleases and oxidative damage as well therefore my main goal is to develop more stable dna nanostructures that can later be used to stabilize vaccines or drug carriers for this purpose i will use metalmediated base pairing in addition to the classical watsoncrick hydrogen base pairing during the project i will design purify and analyse oligonucleotides that stabilize silver nanoclusters agncs in the small size regime with mixed ag0agi composition in order to achieve agncoligonucleotide systems nanoconstructs that can remain stable even in the conditions of the human plasma thus can be used later as vaccines or drug carriers this approach is beyond state of the art since it was not even mentioned as a possible application of metalincorporated dna nanoconstructs in the most recent reviews of the field although already existing data combined suggests it could eliminate many of the issues of previous concepts i will use modern separation spectroscopy and structure quantification methods as well as cellular studies to design and characterise the system that best meets the criteria
algebraic and topological approaches for atomic nuclei and related systems

the primary goal of the current proposal is to understand the structure of atomic nuclei and its evolution by means of algebraic and topological approaches and to employ the algebraic approach to quark gluon plasma the algebraic approach can offer considerable insight into complex dynamics by classifying underlying symmetries derive selection rules calculate many observables and predict many properties in nuclei in a tractable manner the topological approach can offer new insight into the phases of matter of the nucleusthe different objectives of the proposal are montecarlo code for interacting fermions and bosons we will develop a new openaccess code for numerical calculations of fermions and bosons using the montecarlo method mapping the shell model sm onto the interacting boson model ibm we suggest a novel mapping approach based on effective field theory eft in which we write the sm and ibm in eft and investigate the structure of lie algebras of the feynman integrals a method used for calculating multiloop radiative corrections and use them to map the sm onto the ibm topological phases of atomic nuclei we will investigate the occurrence of berry phases in semimagic mid shell nuclei and find classes of topological orders in atomic nuclei by examining known and new analogies with condensed matter physics algebraic approach to qgp we will introduce a new algebraic model for qgp based on bosonfermion effective degrees of freedom with similar principles as the interacting bosonfermion model for atomic nuclei in order to calculate the phase diagram in a tractable framework with insight to the symmetries of the diagram the above objectives can spur more studies by the researcher the supervisor and other experimental and theoretical research groups in different fields of physics and thus the researcher asks for their funding
deciphering and targeting cellular states in glioblastoma

cellular heterogeneity is a fundamental property of glioblastoma gbm tumors and presents a major barrier for therapeutics during the past six years we characterized this heterogeneity in glioblastoma and in other types of glioma using single cell rnaseq scrnaseq we found consistent patterns of heterogeneity across patients such that each tumor harbors multiple subpopulations of cells that resemble neurodevelopmental cell types the consistency of these cellular states across patients highlights their potential clinical significance yet our understanding of how these common states are regulated and of how distinct states respond individually or in combinations to potential treatments remain poorly understood furthermore it is unclear if additional states of clinical significance remain to be uncovered to address these challenges we will perform extensive studies of gbm patient samples animal models and gliomasphere culture models first we will dissect the regulation of the common cellular states aim 1 single cell atacseq of patient samples will be used to infer transcriptional regulators spatial transcriptomics will be used to infer environmental interactions and resulting predictions will be tested further in established model systems second we will search for novel cellular states including rare states or those specifically associated with invasion to the brain parenchyma aim 2 third we will examine strategies for treatment of heterogenous tumors that are composed of multiple states aim 3 we will screen for statespecific drug sensitivities as well as for drugs that induce state transitions and develop rational combinations to eliminate multiple coexisting states while considering interactions among states taken together these studies will considerably expand our understanding of cancer heterogeneity and develop strategies to target heterogeneous tumors
safety of antimalarials in the first trimester an adaptive platform trial

background malaria in pregnancy can have devastating consequences particularly in early pregnancy effective treatment in the first trimester can significantly improve maternal and pregnancy outcomes however firsttrimester pregnancies are generally excluded from clinical trials resulting in new and effective antimalarials being withheld from use in early pregnancy who updated its guidelines in 2022 from quinine to artemetherlumefantrine al as the firstline treatment for uncomplicated malaria in the first trimester however there are insufficient data on the benefitharm of other widely used artemisininbased combination therapiesobjectives 1 to generate robust evidence on the safety tolerability and efficacy of antimalarials for the treatment of uncomplicated p falciparum malaria in the first trimester 2 translate research findings into treatment guidelines and clinical practice study design a phase iiib noninferiority bayesian adaptive randomised platform trial comparing pyronaridineartesunate pa and al in burkina faso kenya and mali primary outcome safety secondary outcomes efficacy and tolerability b formative research to inform innovative trial recruitment and retention strategies c acceptability and feasibility to assess values and preferences of antimalarials during early pregnancy d implementation research to explore factors affecting implementation of al in the first trimester to inform translation strategies and e costeffectiveness of pa vs alimpact the trial will provide critical information on the safety and efficacy of alternatives to al for treatment in the first trimester benefiting settings where al is not used and aligning with whos strategy of multiple firstline therapies against antimalarial drug resistance results will be translated into policy and guidelines and ultimately ensure that healthcare providers and pregnant women have access to optimal treatment options for malaria in early pregnancy
democratising just sustainability transitions

the dust project will develop and operationalise novel participatory instruments for proactive and strategic citizen engagement in sustainability transitions it will combine designled territorial tools with digital tools for citizen deliberation at scale the project addresses a defining societal and democratic challenge for europe which is to hear the voices of least engaged communities especially in structurally weak regions dependent on energyintensive industries which will be most affected by transitions towards a more sustainable future building on the concept of active subsidiarity the project will employ an innovative mix of research methods and experimental citizen participation to understand the determinants of participation in decisionmaking on sustainability transitions at different levels of government and to develop effective policy recommendations for inclusive engagement of civil society
advanced wing maturation and integration

the aeronautical industry is committed to a collective goal of netzero carbon emissions by 2050 in addition to optimized flight operations and sustainable aviation fuels deployment two fundamental enablers to reach this target are the introduction of lh2 technologies and new solutions increasing aircraft and engine efficiency in order to accelerate the entry into service of ultraefficient hydrogen smr aircraft awatar develops a very high aspect ratio strutbraced drywing characterized by laminar portions in the outer areas advanced integrated leading edge systems and an optimized integration of an openrotor propulsion system with the purpose of anticipating and accelerating future certification processes the targeted maturation relies on highfidelity simulations and ground tests etw s2ma collins icing wind tunnelin terms of performance benefits progress to be made in awatar leads to substantial gains with respect to a 2020 stateoftheart aircraft the novel aerodynamic configuration with a large aspect ratio targets a drag reduction at aircraft level of 18 regarding the advanced leading edge solution integrating the ice protection system the investigated technology aims for a 50 reduction of the energy budget needed for a fully evaporative system for laminarity the expected aircraft drag reduction is about 510 depending on the configuration in addition the optimized integration of the unducted single fan limits installation drag to less than 4 of total aircraft drag overall awatar aims at an integrated smr aircraft 250 passengers 2000 nm offering an 18 reduction in block energythis 36 months 20meuros valued project 14meuros funding relies on a strong consortium made of 2 aircraft manufacturers 1 aerospace components supplier 3 research centers 1 wind tunnel operator and 2 universities this complementary and multidisciplinary consortium ensures that awatar maturity path is in line with clean aviation smr roadmap
dna modules as communicators in tumor immunomodulation

our goal is to develop alldna structures protocells that can act as modulators of the immune system and in particular of signaling processes in oncology molecular dna switches that interact with cells via aptamers have been developed and used for drug delivery cell imaging and potential therapies however there are several advantages of incorporating these swithces into protocells such as the protection of these circuits against degradation the ability to create gradients and as a delviery method for in vivo application dna protocells that i have the ability to recognize proteins and small molecules and ii amplify signals and generate output that alters cell physiology have not yet been developed realizing these structures requires filling a gap in our knowledge of how of how aptamer reactions network in confinement we anticipate that by filling these gaps in our knowledge we will be able to produce a pure dna protocell that can harbor aptamerbased response networks for modulation of intercelullar communication in the tumor microenvironment
variations in motivation across the day understanding the how and why of daily fluctuations

life on earth has evolved in synchrony with the daynight cycle most species from singlecell plants to humans have a circadian system that operates as a pacemaker modulating a multitude of biological processes across the 24h period given the ubiquitous involvement of the circadian system in our physiology it is not surprising that motivation and related neural systems such as dopamine also vary across the day but with large variation between individuals timeofday is increasingly being utilised to strengthen treatment effects and facilitate behavioural change however we still lack fundamental mechanistic knowledge for establishing more effective and widespread therapeutic applications in mental health care as well as in daily life hence there is a need to more fully understand the circadian clock of motivation and drive the objective is first to predict when ie at which time of day drive and motivation are heightened and blunted and second to scrutinise the underlying cognitive and neural mechanisms specifically in phase 1 i plan to conduct a largescale field study using a mobile application to quantify fluctuations in motivation to engage in dailylife behaviours and cognitive mechanisms including incentive motivation reinforcementlearning and cognitive flexibility then in phase 2 i will use this knowledge to probe the role of dopamine in timeofday effects of motivation by pharmacologically modulating dopamine at different times of day in a subset of the participants from phase 1 the combination of field research and basic experimental research will provide unique and clarifying knowledge of how and why motivation fluctuates both within and between individuals given the significant role of motivation in the healthy and sick brain the results will provide novel valuable insights for the society at large
hacking the ribosome to map virushost associations

high throughput sequencing and metagenomics have deepened our understanding of viruses in nature yet linking viruses to their hosts remains a challenge hindering our knowledge and applications the virhox project aims to overcome this by hacking the ribosome to map virushost associations leveraging a critical moment in the infection cycle of all viruses the translation of viral genes into proteins by the host cell we will uncover concealed relationships between viruses and their hosts providing a universal tool for virushost pairing this novel approach virhoseq involves ligating host ribosomal rna with viral mrna during translation in infected cells using engineered enzymes followed by high throughput sequencing to reveal virushost pairings our interdisciplinary consortium of academic and industrial experts in microbiology protein engineering gene editing viral genomicstranscriptomics and law will develop and then prepare the commercialisation of virhoseq envisioning legislative and analytical frameworks to maximise its impact this technology will significantly help tackle current challenges such as those posed by emerging pathogens ecological disruptions and climate change our approach aligns with the eic work programme objectives demonstrating feasibility on model organisms before validating on relevant samples addressing the engineered living materials challenge
multimessenger studies of extragalactic supercolliders

active galactic nuclei agn are among the most powerful particle accelerators in the universe they convert the gravitational energy of matter accreted by supermassive black holes smbhs into electromagnetic and kinetic energy producing highly relativistic electrons and protons they are most likely originated from the vicinity of smbhs but the exact mechanism of their production remains elusive electrons are predominantly found in jets whose acceleration and collimation are still poorly understood even less clear is how and where protons are accelerated and how this process is connected to neutrino production the importance of investigating such highenergy particles transcends astrophysics as they probe regimes that particle accelerators on earth will likely never reachthe recent detection of a highenergy neutrino signal from the blazar txs 0506056 by the icecube neutrino observatory has brought up new multimessenger opportunities for agn studies which can be now most efficiently explored this proposal sets its main aim on carrying out such an exploration and addressing the pivotal questions about proton acceleration jet formation and collimation and neutrino production in agn to achieve these goals we will perform and utilize observations of agn across the electromagnetic spectrum with a particular focus on highresolution verylongbaseline interferometry and data collected by highenergy neutrino telescopesthe information and insight gathered through these investigations will provide the most accurate clues about the extreme energy output in agn and transform these objects into wellunderstood cosmic laboratories which can probe physical conditions unachievable in any experiments performed on earth
european spacegrade optical transceivers for high speed intrasatellite interconnects and free space lasercom links

in the current booming satellite ecosystem optical communications are now the champions of data handling they are a must for supercapacity transmission systems and they are a must for smaller and lighter payloads the core enabling technology of these systems is the optical transceiver in its most advanced versions it is deployed either in the form of vcselbased or as integrated coherent lightwave modules these complex products encompass diverse technologies such as lasers electronic and photonic chips microoptics optical and electrical interfaces all in sophisticated miniature packaging european sovereignty in producing such critical devices is of strategic importance but to this date a continental supply chain is missing this is where spacelink come to play spacelink is a natural evolution of h2020spaceorionas and siphodias two successful eu funded projects which have demonstrated optical transceiver circuits and modules to trl 4 establishing the groundwork for the evolution and delivery of flightready hardware spacelink is setup to take the next step and through its manufacturing assembly integration and test campaign will evolve the technology maturity and demonstrate flightready parts at trl 7 spacelink aims to establish the first european supply chain of hirel optical transceivers removing dependency barriers and securing europes digital sovereignty leveraging highend technologies in which europe has and continues to invest spacelink will deliver optical transceivers made in costeffective waferscale fabrication spacelink will deliver vcselbased and photonic integrated circuit systems that will challenge usmade solutions with drastic improvements in size weight and power performance and manufacturability
twinning for excellence in morphing and aeromechatronic wing control a leap towards ecosmart aviation

sustainable aviation is an important part of the european green deal program a significant way to achieve this is by reducing wing aerodynamic drag and loading an attractive approach to this is through wing shape morphing aeroelastic control and lightweight structures however morphing requires low wing stiffness aeroelastic control requires high wing stiffness and lightweight structures require different composite materials the mechatwing project aims to resolve these contradictions by introducing a new innovative design of a mechatronic wing using the scientific and innovative competencies of project partners in disciplines such as aeronautics mechatronics structural design material mechanics additive technologies and robotics around this research topic as the backbone the twinning activities between the czech technical university in prague ctu and three top aerospace research institutions the german aerospace center politecnico di torino and technische universitt wien are organized the main mechatwing objective is to bolster ctus excellence capacity and resources thereby closing the still apparent research and innovation gap within the eu ctu aims to achieve this through a targeted knowledge exchange with project partners institutions renowned for their substantial industry alignment and collaboration this will involve the secondments of 11 ctu researchers and students and 4 administrative workers to these institutions exposing them to stateoftheart practices expert mentoring will further support ctus earlystage researchers and research support staff the project partners will send specialists to ctu enhancing its academic environment ctu will also conduct workshops and seminars to integrate new knowledge and techniques by incorporating czechinvest as an associated partner the consortium will enhance ctus efforts to strengthen its relationships with both local and international business and investment communities
a cellular immunotherapy virtual twin for personalised cancer treatment

this project aims to create a multiscale patientspecific human virtual twin for patients who are eligible for car t cell therapy which can be extended to cellular immunotherapies in general the virtual twin will be fully integrated into the ecosystem under the digital europe programme and will be available as a researchuseonly prototype in relevant application environments with technology readiness level 6 the virtual twin will support decisionmaking throughout the patients journey from diagnosis to pretreatments cellular immunotherapy and late patient monitoring this will enable patients and health experts to identify the most effective course of therapythe virtual twin for cellular immunotherapies will take multiscale modelling to the next level by providing methodological concepts for integrating living drugs such as car t cells into the human virtual twin ecosystemto achieve this goal the project builds on existing data models for hematological malignancies and multiple myeloma mm to create a virtual twin for car t cell therapy for mm patients the implementation process follows software development principles for software as medical devices ensuring the exploitation of the researchuseonly prototype patients ssh gender differences and other stakeholders perspectives are fully integrated into the design specification and implementation processthroughout the implementation process a modular software architecture and extensible ontologiesterminologies are utilized making the reference model easily transferable to other indications that can be treated with car t cell therapy or other cellular immunotherapies overall the certainty virtual twin will provide decision support for patients and health experts improving the effectiveness of cellular immunotherapies and advancing precision medicine