Dragon09/odtu_chatbot huggingface dataset:
smart sponge microbiomes adaptation and resilience to thermal stress

marine sponges the multicellular and sessile with associated microbes constituting 40 of their biomass are vital in marine ecosystems for habitat creation nutrient cycling carbon sequestration biodiversity support and water filtration this project investigates how associated microbes enable sponges particularly the blue icing sponge lendenfeldia chondrodes to adapt to heat stress by studying microbial communities we explore their influence on sponge resilience survival and recovery from hightemperature conditions the findings contribute to global climate change understanding the findings could contribute to the european unions commitment to safeguarding marine biodiversity and ecosystems ensuring longterm resilience and sustainability unravelling the roles of microbes in sponge adaptation holds broader societal implications including improved ecosystem management conservation strategies and the development of early warning systems for monitoring environmental stress while previous studies have explored microbial associations in sponges under stressful conditions the specific focus on the adaptation of blue icing sponges to heat stress and their potential as early indicators remains unexplored the interdisciplinary nature of the project combining molecular biology omics studies metagenomics and metatranscriptomics ecology and bioinformatics promotes collaboration and knowledge sharing across disciplines economically and technologically identifying microbial indicators of environmental stress can facilitate the establishment of early warning systems and monitoring protocols leading to more efficient conservation efforts and reduced costs associated with ecosystem degradation societally the outcomes of this research can influence policies and decisionmaking related to marine conservation and climate change mitigation the project will also support professional development through knowledge dissemination and research publication
thermospin 3d platform for skyrmion motion

the overall power consumption of information technology accounts for almost 10 of the global energy demands and it is predicted to reach 20 in 2030 as a result we need new ways to store and compute data utilizing more efficient and environmentally cleaner alternatives to current technologies and the eu should be leading this transformation the development of a lowpower nonvolatile memory is one of the most soughtafter technologies and racetrack memories based on topological magnetic skyrmions are one of the most promising candidates there are however several drawbacks for spintronic devices based on skyrmions their trajectories under currents are nontrivial the thermal contribution to skyrmion motion is yet to be well understood and fully electrical detection of skyrmions is challenging due to the small contribution of the topology to the hall effect in 3dsky i propose to take advantage of stateoftheart 3d nanopatterning to obtain fine control over the energy landscape for the motion of skyrmions in 3d racetracks for this i will exploit the precise and unique tuning of thermal and geometrical properties that 3d devices enable to decouple the nanostructure from the substrate opening the possibility to use much higher temperature gradients to tackle the main drawbacks of skyrmion racetrack memories in short in 3dsky i aim to create a platform for skyrmion motion based on 3d nanodevices focusing on the impact of temperature on their dynamics nucleation and properties this will provide the fundamental knowledge needed to understand thermaldriven skyrmion motion in different systems including the different driving forces in play furthermore i will tackle the current challenges in reliable nucleation and electrical detection of skyrmions taking advantage of the singular properties of 3d nanostructures for the creation of defects and efficient heating
delivering clean affordable and safe nuclear energy with the compact molten salt reactor

seaborg proposes a novel type of nuclear reactor called the compact molten salt reactor cmsr our ambition is to use the csmr to complement and not substitute other sustainable energy sources like renewables to accelerate the global decarbonization processthe cmsr works according to different principles than the existing nuclear power plants it is safe by design by the physics of nature cannot melt down or explode and reduces radioactive waste the goal is to recycle spent fuel waste to reduce footprint and storage the cmsr emits no greenhouse gases while operating and has the lowest resource use concrete glass steel fuel of all other energy sources including renewables the cmsr outcompetes fossil fuels on free market terms the levelized cost of electricity is about 50 the one of coal and 70 the one of gasseaborg is the largest nuclear reactor startup outside of north america and it has patented technologies prestigious partners and pilot customers
mobilising investments for protecting and restoring biodiversity by harnessing innovative financial solutions and advanced geospatial analytics

biodiversity protection and restoration are critical for maintaining the ecological balance and ensuring the planets sustainability in the absence of sustainable management and protection of natural resources the negative impacts of climate change and other environmental issues will only increase private investment can be a critical tool that has the potential to play a transformative role in financing conservation and restoration efforts as public financing alone may be insufficient to address the scale of these challenges by activating innovative sustainable finance solutions and incorporating technological advances within the field of geospatial analytics the project can attract private investment in a way that benefits the environment and secures investors confidencebiocapital project is going to develop and implement an interdisciplinary research and innovation endeavour by combining actions in the three fields of i biodiversity protection and restoration ii biodiversityfriendly financing mechanisms and iii advanced space technology the implementation will involve three key steps to leverage innovation first biocapital will analyse understand and learn from ucs second it will elaborate monitor and demonstrate through ucs finally it will codevelop implement and amplify back to the ucs biocapital will engage stakeholders through iterative processes in order to reach shared views on the aforementioned three stages and how they can be effectively combined to increase financial flows for biodiversity protection restoration and sustainable utilisation
engineering viral vectors for highthroughput crispr genetic screens in plants

tools based on crisprcas systems hold great potential both for fundamental plant genetics and precision crop breeding unlike traditional mutagenic approaches crisprcas systems allow for the simultaneous delivery of thousands of unique guide rnas enabling the generation of collections of higherorder mutants for rapid functional screens and the discovery of genetic interactions however crispr technology suffers from a transformation bottleneck relatively few crop genotypes can be transformed and often only a handful of mutant lines can be produced in virusinduced genome editing vige plant viruses are engineered to deliver grnas into cells such a capability is highly attractive for crispr knockout ko screens as it could simplify the delivery and generate large populations of mutant lines in a broader range of crop genotypes however the application of vige for crispr ko screens is hampered by the lack of a proper viralbased multiplex grna delivery vector my host lab has pioneered the development of crispr ko screens in plants and in viscreen i will combine this knowledge with my expertise on vige to scale up crisprcasmediated manipulation of plant genomes the main objectives of my project are i to develop barley stripe mosaic virus bsmv for highthroughput crispr screens in wheat and maize and ii to engineer and validate a set of viral vectors for vige in soybean the viral vectorbased highthroughput editing systems developed in viscreen will expand crispr screens in a wider variety of crops and allow to test fundamental biological questions that are limited by functional redundancy overall this innovative approach will make me a welltrained academic researcher with the capabilities to develop a professional career within the plant genome editing field
mesoscopic understanding of supported catalysts with overlapping electric double layers

a defossilized global energy ecosystem hinges on efficient conversion between renewable electrical energy and chemical energy stored in molecules this conversion requires precious catalysts to drive relevant reactions at practical rates many catalysts are employed in the form of nanoparticles np dispersed on support materials all relevant reactions occur in a nanoscale region at the interface between the solid catalyst and an electrolyte solution ie an electric double layer edlour current knowledge of edl is essentially limited to planar electrodes with a single edl whereas supported np catalysts snpc exhibit radically different edl characteristics featuring overlap of individual edls around the nps and the adjacent support material this knowledge gap concerning crucial local reaction conditions within the edl prevents effectively transferring knowledge obtained at planar electrodes to performance improvements of snpcmesocat aims at launching the mesoscopic 1100 nm science of overlapping edls in snpc and unravelling the influence of overlapping edls on structureactivity relationship of snpc mesocat will address three foundational questions in electrocatalysis of snpc using theoretical methods in an interaction loop with experimentalists first how are the overlapping edls formed under realistic conditions this will be studied using a unique theoretical approach for mesoscale edls with both quantum mechanical electrons and classical electrolyte particles treated on equal footing second how do overlapping edls influence elementary electron transfer kinetics this will be unravelled using a model hamiltonian for protoncoupled electron transfer considering various edl effects third how do overlapping edls influence the overall structureactivity relationship this will lay the groundwork for transformative advancements in electrochemical energy conversion via regulating the mesoscale edl effects
european higher education institutions network for climate and atmospheric sciences

the eastern mediterranean and middle east emme region faces rapid population growth currently about 400 million inhabitants as well as political and socioeconomic instabilities these challenges experienced by a part of the world that is already hot and arid are exacerbated by droughts and the extreme weather conditions associated with rapid climate change extremes of temperature in combination with increasing air pollution and windblown desert dust could in the near future lead to intolerable conditions ultimately compromising human habitability and promoting migration since climate change and air quality share many common sources it appears logical to focus on the development of amelioration strategies that combine the goals of limiting climate change and reducing air pollution it has been estimated that mankind may have a relatively smalltime window up to the middle of the century in which to implement solutions to these challenges particularly as far as climate change is concerned edu4climate will engage advanced partners from france austria germany finland to strengthen the scientific excellence of higher education institutions heis from twin islands of widening countries greece cyprus with a view to establish a regional hub of knowledge in air pollution and climate change research and innovative solutions engaging their respective surrounding ecosystems from the quadruple helix in addressing these societal challenges over the wider emme edu4climate will enhance local regional and international clusters led by its consortium with a view to build the foundation of an inclusive european universities alliance made of advanced and widening heis in climate atmospheric sciences to optimally support the current eu green deal ambition and its regional challenges train and educate the next generation of researchers and innovators to achieve the eu longterm 2050 climateneutrality objectives
development of a toolbox to improve preparedness strategies on surveillance in humananimal interface and countermeasures to reduce recurrent ebola impacts

the recent outbreak of ebola virus ebov in particular the ebov sudan strain is a major cause for concern as there are currently no available vaccines and treatments for this fatal disease moreover surveillance measures are suboptimal and the social response to viral outbreaks hindered by limited acceptance of countermeasures the ebola preptbox consortium aims to make significant strides in developing essential tools and strategies for effective surveillance response and control of ebola outbreaks fostering a safer and resilient futureour objective is to build a toolbox permitting earliest ebola outbreak containment a spatiotemporal model utilizing environmental animal reservoir socioeconomic and human movement data will be developed enabling prediction of future outbreaks the sensitivity of current diagnostics will be improved through innovative viral capture techniques ebov exposure and immune response will be tested from humananimal interface samples from the republic of congo roc democratic republic of congo drc and uganda new treatments for the ebov sudan strain will be developed by testing for broadspectrum activity of the ebov antizaire equine polyclonal antibody further development of mosaic antigens composed of several filovirus strains incl ebov will create new tools for broadspectrum vaccine and therapeutic development conductance of knowledge attitude and practice kap studies gap analysis and targeted trainings in roc drc and uganda will improve population acceptance for future ebov outbreak interventions the training of african researchers by the consortium will increase local skills and competencesebola preptbox is an interdisciplinary and complementary consortium including partners from the congo basin fcrmroc inrbrdc uvriiaviuganda prof jj muyemb ebola discoverer 1976 and partners from europe fabentech and bacflycnrsfrance imas12spain and the support of g kobinger gnlus
determining impact of viruses on biogeochemical processes in soil

microorganisms have a central role in soil biogeochemical processes essential functions include nutrient cycling controlling greenhouse gas fluxes and supporting crop productivity soil is one of the most diverse habitats in the biosphere high throughput sequencing has enabled characterisation of microbial communities and determination of drivers such as climate and land use are well underway however we are only beginning to recognise the scale of viral diversity in soil and importantly the impacts of virushost interactions on key soil biogeochemical cycles and subsequent functional consequences on ecosystems are unknown viruses have a range of life strategies including infection and lysis of host cells or integration followed by lysis facilitating horizontal transfer of genes and augmentation of function when a host is lysed cell contents are released into the labile organic matter pool in marine systems 40 of prokaryotes are lysed per day releasing 150 gt carbon per annum however there is a paucity of information about the impact of topdown control by viruses on soil populations nor the scale of the viral shunt of nutrients it is likely that viruses have a major impact on microbial diversity and nutrient cycling with consequences for ecosystem processes here we propose a research programme that not only aims to characterise active viral communities in situ but advances the stateoftheart by identifying actual impacts of viruses on selected key biogeochemical processes specifically using a series of soil microcosm incubations utilising 13c stable isotope analysis high throughput metagenomic and metatranscriptomic approaches in combination with measurements of soil n and c fluxes we will characterise for the first time active viruses together with direct measurements of their impact on biogeochemical cycles
strengthening ethics and responsible conduct of clinical trials in east and subsaharan africa

the increased number of clinical trials taking place in africa as well as the complexity of clinical trials designs require that the countries have the regulatory capacity to review monitor and utilize data generated from the research research ethics committeesinstitutional review boards institutional animal care and use committees and national regulatory agencies nras are required to be abreast with the evolving landscape thus require continuous capacity building as well as have platforms to share clinical trials information with both the public and private sector the 11th annual national research ethics conference held in 2021 in uganda highlighted challenges in the low and middle income countries for research ethics and open science specifically the lack of infrastructure for open data sharing and fair data management specifically i lack of the national and regional guidelines and codes of conduct for scientific integrity ii limited training and education in responsible conduct of research and pharmacovigilance this proposal focuses on strengthening ethics and responsible conduct of clinical trials in east and subsaharan africa project through the establishment of a research ethics and integrity framework open data access framework for clinical trials elearning platform for the good research regulatory research practice course and establishing research ethics committees in national regional hospitals the consortium will leverage on the legal establishment of the institutions collaborative efforts with the partner institutions east african health research commission eahrc african vaccine regulatory forum avaref having a robust regulatory system encompassing research integrity and open science will ensure that clinical trials is conducted to the highest ethical standards and in compliance with existing polices and laws hence protection of safety rights and welfare of the individual participants community researcher and sponsors
network fairness a novel complex network approach for tackling inequalities in society and algorithms

social inequalities are on the rise and will have devastating impacts on education healthcare economiesand societies for many generations to come structural barriers to equality despite being complex and dynamicare poorly understood through the lens of complex evolving social networks more crucially withthe rise of ai and machinelearning algorithms it is extremely important to detect forecast and mitigatethose inequalities in a systematic manner in order to avoid unintentional algorithmic consequencesa network fairness framework is proposed premised on topological and temporal features of social interactionsthat shape the formation and evolution of inequalities these features include 1 people havemultiple and correlated attributes that determine how they identify with groups and interact with others2 people belong to a variety of social groups with different sizes hierarchies and historical precedentsand 3 interactions between people evolve over time in a hybrid space of society and algorithmsto this end i will develop a suite of dynamical complex network models of inequality that are driven bysocial theories eg homophily intersectionality consolidation and calibrated and evaluated with big dataand network experiments this will allow us for the first time to investigate inequalities that arise fromnetworkbased algorithms in a systematic manner more importantly i will devise a novel methodology ofnetwork intervention a set of datadriven principles for tackling network inequalities in a broad range ofapplications finally based on the models developed in this project i will create a cuttingedge interactivesoftware netfair to visualize and forecast the evolution of inequalities and implement various fairnesscriteria the software will contribute towards bridging the gap between research and policy applicationsin academia and industry
deciphering the mechanistic basis of minimal residual disease and treatment resistance in acute myeloid leukemia

acute myeloid leukemia aml is one of the most aggressive and deadliest cancers with frequent relapse although initial therapies eliminate most aml blast cells rare cells with leukemic stem cell lsc activity can persist and likely generate minimal residual disease mrd to reinitiate aml thus targeting resistant lscs during mrd might provide a unique opportunity to prolong remission and prevent relapse however because it is notoriously challenging to identify rare lscs present within the vast number of normal blood cells during mrd the phenotype plasticity function and mechanisms of lscs in resistance and relapse remains poorly understoodprevious study from the trumpp laboratory demonstrated a convergent pathway via hypermethylationn to drive initiation and progression of aml with idh mutations or bcat1 overexpression however the common and distinct mechanisms driving resistance in the two aml subtypes has not been explored despite the observation that bcat1 expression is upregulated in lscs and upon relapsethus in this proposal i will first perform systematic phenotypic characterization of idhmutbcat1hi aml cells to develop a highquality lsc enrichment strategy subsequently i will combine cutting edge singlecell multiomics technologies to deeply characterize the mutational transcriptomic and epigenetic dynamics of individual lscs at diagnosis mrdpositive remission and relapse state of the art analytical methods will be used to integrate these data to dissect idhmutbcat1hi aml with unprecedented resolution examine the contribution of lscs in mrd and identify molecular regulators mediating lsc survival and resistance functional validation using pharmacological intervention genomic editing in cell lines and patientderived xenograft models will be performed to uncover causal relationships of the identified regulators overall this work will lead to better mechanistic insight of mrd and therapy resistance in idhmutbcat1hi aml