Dragon09/odtu_chatbot huggingface dataset:
solidarities and migrants routes across europe at large

unauthorized migration has always been a contentious issue in the eu yet many of the policies adopted thus far have proved ineffective in containing arrivals and blocking circulations of migrants and refugees within the eu furthermore unauthorized migration has continued to challenge eu borders even during the pandemicsolroutes core research question is how can the turbulence persistence and intensity of unauthorized movements and of the production of migrants routes across europe at large originating from the externalization of eu borders to noneu countries be understoodthe project addresses this challenge from an innovative angle through an ethnographic exploration of the nexus between unauthorized movements and the networks of solidarity with migrants in transit which involve actors and practices that have been addressed just recently in migration studies this will be achieved by exploring and observing 50 crucial nodes in migration routes within europe in selected countries on its fringes turkey tunisia morocco and in the outermost regions of the eu french guiana mayottesolroutes will aim to a explore the functioning articulations and representations of local and translocal networks which share shelter knowledge and resources with migrants in transit b assess how routes are continuously reshaped by the encounter between unauthorized movements and solidarity networks c develop a largescale multisited ethnographic approach based on live and collaborative methods and digital research d develop an innovative theory in migrations studies on the nexus between solidarity with migrants in transit and unauthorized movements contributing to structure the emerging perspective of solidarities studies e generate special features a web series an art exhibit a graphic novel linked to the research offering new narratives for policy makers local communities and other relevant audiences in the spirit of public sociology
a minimally invasive and durable endograft fastening solution for abdominal aortic aneurysm aaa

abdominal aortic aneurysm aaa is a focal enlargement of the abdominal aorta below the renal arteries and is found in up to 4 million patients globally each year if left untreated it can be fatal so it is imperative to provide early prophylactic treatment before a rupture occurs the available treatment options are far from optimal open surgery is a durable lifelong but highrisk solution the alternative evar has lower immediate risks but is a shorterterm solution and requires continual monitoring and secondary interventionswe have developed aortoseal a fixation and sealing implant for endovascular aneurysm repair that combines the best of both worlds the stability of an open sutured repair and the safety and lowrisk delivery of evar aortoseal will reduce the need for open surgery the need for secondary procedures and time in the hospital all leading to improved patient outcomes and projected healthcare savings over a 10 year period of 9 bn across the eu
graphene europe in the lead coordination and support action

the graphene flagship gf initiative aims at advancing europes strategic autonomy in technologies that rely on graphene and other 2d materials and sustaining the firstmover advantage that europe has obtained through earlier investments this overarching goal will be pursued by a number of graphene and 2d materials 2dm related actions research and innovation actions rias and innovation actions ias in collaboration with activities funded by the eu member states and associated countries the overall coherence of the gf initiative is guaranteed by a coordination and support action csa that allows the separate actions to exploit synergies in their scientific and technological activities and work more efficiently by utilising common services and support functionsgrapheneeu builds upon the extensive experience and expertise of a consortium that has been responsible for the central support and coordination functions of the graphene flagship during the fp7 and horizon 2020 phases and therefore has access to the broad network of researchers and organisations which will participate in the gf initiative grapheneeu will ensure a strong and coherent initiative by providing key support functions in coordination and governance industrialisation dissemination and alignment enabling the participating projects to identify and utilise synergies in their work share best practices and promote interactions with relevant national and regional initiatives grapheneeu will help secure a sustained european leadership in 2dm by capitalising on the investments in the graphene flagship from the fp7 and horizon 2020 phases and fostering and facilitating the work to be continued during horizon europe
new measurement of ultrahigh energy interactions using radio detection of cosmic ray air showers

the pierre auger observatory detects extensive air showers that are initiated by protons or nuclei reaching earthsatmosphere with energies exceeding 1018 ev ultrahigh energy cosmic rays uhecr the centerofmass energy of the initial interaction of the crs in the atmosphere exceeds the energies reached at the lhc by more than an order of magnitudeone of the key results of auger is the discovery that these interactions of uhecrs do not behave as expected compared to simulations the measured air showers contain many more muons this discrepancy could be simply due to the uncertainty inherent in the extrapolation from the energy scale of the lhc where we can measure interactions in detail to uhecr energies or it could be new physics this project proposes to distinguish the two scenarios by the detailed measurement of the showertoshowerdistribution of the muon content as the shape of the distribution is driven by the quantum fluctuations in the first uhe interaction which are sensitive to new physics and the details of hadronic interactions the measurement will for the first time use hybrid data from the surface and radio detectors of the pierre auger observatory
supramolecular organization and dynamics of presynaptic proteins

since the prophetic vision of the german scientist emil du boisreymond in 1877 that put forward the hypothesis of the chemical nature of synaptic transmission a large number of biochemical genetic and neurophysiological studies have revealed all the components that are involved in synaptic vesicle sv exocytosis this complex actionpotentialtriggered process in which the entry of calcium ions ca2 into the presynaptic compartment induces a millisecondsfast fusion of neurotransmittercontaining svs with the presynaptic plasma membrane pm requires a number of socalled presynaptic proteins playing different roles to date despite all the knowledge acquired about presynaptic proteins the question how they carry out this fast process remains unanswered recently it was hypothesized that the presynaptic proteins are organized in specific supramolecular arrangements and do cooperate to achieve this remarkable feat however the study of presynaptic protein arrangement and functioning at nanometer isotropic scale is challenging and decades of research were unable to resolve this phenomenon in this project i plan to study the threedimensional supramolecular structures of the presynaptic proteins during sv exocytosis at nanometer isotropic resolution and its structural dynamics on the nanometer length scale with microsecond temporal resolution for this purpose i will combine the superresolution technique singlemolecule metalinduced energy transfer smmiet developed by the host group with the singlemolecule localization microscopy smlm methods of dnapaint and minflux the overall importance of this proposal in understanding the ca2triggered sv fusion is that it is essential to understand how synapses and ultimately the brain work and all derived knowledge and applications that comes with it
microbial life of sea ice habitats investigated for the arctic

unprecedented warming in the arctic is threatening microorganisms of the sea ice biome that support life in the marine ecosystem and influence atmosphereocean interactions of climate relevant gases like co2 yet characterisation of sea ice biodiversity an index of system susceptibility to environmental change and its productivity are dangerously incomplete these shortcomings largely stem from the biomes complexity which is a dynamic relation of several microhabitats and an oversimplified focus on photosynthetic activity in only a subset of all microhabitats present my pilot research indicates these deficiencies likely misrepresent the biomes resilience to warming and its function as an autotrophic carbon source in the arctic oceanmicroshift tests this hypothesis by targeting critical knowledge gaps on microbial diversity and production for the range of microhabitats truly comprising the sea ice biome in doing so it defines the contribution of sea ice to arctic marine biodiversity and production and addresses uncertainties highlighted by the intergovernmental panel on climate change ipcc the multidisciplinary project traverses microbiology geography and biogeochemistry it uses novel innovations for sampling microhabitats in targeted field campaigns and laboratory experiments to identify the biomes resiliency together these breakthroughs enable modelling that completely accounts for biome productivity now and in the future microshift would be the first holistic project considering all sea ice microhabitats together it is an ambitious task but one that i am ideally suited for with 10 years of sea ice experience in this time i have laid the foundations to accomplish project objectives developing essential o2based approaches and completing pilot studies that build best practices project outcomes will transform our view of the sea ice biome revealing how we can expect this fragile system to change as the arctic continues to warm
advanced intelligent stimulation device hand movement restoration

very advanced stimulation paradigms applied to peripheral nervous system pns have been studied for years even decades amongwhich the 3d current distribution through multicontact epineural electrodes non rectangular stimulus waveforms are also of stronginterest to provide more efficient or fibre type selective stimulation however none were implemented in an active implanted medicaldevice and thus almost none validated through clinical trials one of the reasons is the high complexity of the needed analogue frontend and its safe control by a microcontroller or a digital system aihand project aims at developing a breakthrough asic basedtechnology together with a specific self adapting epineural multi contact electrode to provide such an aimd the demonstration ofthe clinical relevance of such an approach will be achieved through a firstinman proof of concept aiming at the restoration of handmovements in persons with complete quadriplegia it means that a full innovative device should be developed and validated inanimals but the real added value will be supported by the clinical trial indeed no animal model exists while the clinical needs isclearly stated by clinicians and patients thus this project will innovate concerning both the technology and the therapeutic approachwith a minimally invasive concept indeed spatial selectivity allows to stimulate nerves selectively targeting muscles through 3dcurrents shaping instead of implanting one electrode per muscle the technology clearly addresses generic issues so that the paradigms and the innovative technology can be further used to stimulate the central nervous system spinal cord and brain and on a long term basis may drastically open new therapeutics for medical needs that are still unmet
sustainable water management doctoral training programme

the sustainable water management swm doctoral training programme water4all brings together complementary expertise of a diverse group of researchers from 4 leading universities to offer unique interdisciplinary intersectoral and international research and training opportunities for 20 highly competitive doctoral candidates dcs the leading academic institutions from the biggest cities in turkiye are izmir institute of technology iztechbeneficiary istanbul technical university itu gebze technical university gtu and middle east technical university metu water4all is constructed by integrating academic and scientific training modules which cover different aspects of sustainable water management the main modules are identified as environment electronics planning material science and energy and each has different angles of training on research and expected outcomes in this respect academic training of dcs in water4all is constructed in a modular approach that is interdisciplinary by nature academic training is coupled with a welldefined set of academicnonacademic internationalnational secondment trainings highlighting the international axis of the proposed programme and with a series of common trainings granted to each dc in soft and transferable skills water4all will widen the career perspectives of dcs by enhancing their professional experiences through the inclusion of secondments in renowned international and national academic institutions private companies and public utilities ensuring intersectorality and internationality through these collaborations thus water4all will increase the national regional and european competitiveness by providing a new generation of highlyqualified experts in swm that are able to translate applied science research results into solutions supervisors selected for water4all have previous andor ongoing industry consultancyresearch collaborations
the mitochondrial paradox embracing mitohormesis for improved metabolic and aging health

obesity and aging are two of the most important health challenges facing our societies in the 21st century however there are currently no effective therapeutic approaches to mitigate the growing obesity pandemic or to promote healthy aging therefore it is essential to explore new research frontiers in order to develop more effective and safer strategies mitohormesis the process by which induced mitochondrial stress can trigger beneficial health effects has emerged as a promising area of study in biomedical research however its potential effectiveness against metabolic and agingassociated disorders in vertebrate organisms is poorly explored we have generated a mouse model that exhibits enhanced mitohormesis in the vascular endothelial cells in this proposal we intend to conduct a proof of concept to assess whether triggering endothelial mitohormesis can serve as a novel approach for treating obesity and agerelated health issues to this aim we will execute 4 work packages to determine a the preventive and b curative effect of endothelial mitohormesis on obesity and associated metabolic alterations c the impact of the promotion of endothelial mitohormesis on aging markers d the identity of new circulating mitohormetic mediators with the potential to be pharmacological targets these studies will be carried out by a research team with an extraordinary trackrecord in the fields of metabolism and aging our objective will be bringing the technology from trl3 to trl4 by evaluating the performance and feasibility of the technology in a controlled laboratory environment the research team will closely work with the tech transfer office to ensure the implementation of a successful ipr strategy a therapy based on the controlled induction of endothelial mitohormesis could have a great impact on the quality of life of millions of patients reduce the burden of chronic diseases on the health system and have important economic repercussions
metabolic imprinting of th17 cells in disease pathogenesis

autoimmune diseases affect an estimated 39 of the population and cause major personal and socioeconomic consequences il17producing cd4 t cells th17 are recruited to inflamed tissues and involved in autoimmune pathogenesis but were recently also shown to have homeostatic function in tissues preliminary data from the outgoing host indicate that th17 cells are transcriptionally distinct in different tissues how tissue th17 cells acquire such specialized characteristics remains elusive based on recent findings from the lab that a metabolic manipulation affects th17 cells we hypothesize that metabolic cues from the target tissue dictate th17 phenotypes to address this we will apply scrnaseq and the host lab developed compass metabolic flux tool in 9 tissues hits from this analysis will undergo a novel screening approach chime to reveal effects on th17 function in autoimmunity th17 cells reside within different tissues before migrating to the inflamed tissue identifying a tissue metabolic switch for th17 cell pathogenicity might thus pave the way for novel treatments to study this i will use a mouse model for the autoimmune disease multiple sclerosis ms for target validation during the return phase the findings will be set into context of tissue niche immunology and human biology in healthy versus inflamed human tissue spatial rnaseq will directly reveal metabolism related differences in a natural tissue niche context the project will be performed in a worldrenowned th17 lab the fellow brings extensive experience with tissue immune cell extractions and ms mouse models enabling immediate project progression the fellow will then bring back novel techniques and experience scrnaseq chime to the return host where she will acquire skills in human tissue niche immunology and spatial rnaseq this project will enhance her expertise research and transferable skills and allow to build a network to follow her goal of becoming an independent pi
reassessing bacterial cell cycle regulation revealing novel regulatory principles in realistic environments

antibiotic resistance is quickly becoming one of the greatest healthcare challenges of our time it is soon expected to claim more lives annually than the covid19 pandemic or cancer yet the urgency of this problem is not reflected in our efforts to solve itbecause blocking bacterial growth is key in treating disease greater insight into the bacterial cell cycle is needed currently the bacterial cell cycle is primarily studied under optimal lab conditions this is equivalent to studying the behaviour of an animal kept prisoner in a zoo although valuable observations can be made essential information will be missedto obtain a more accurate view of bacterial growth i will investigate the cell cycle of the major human pathogen streptococcus pneumoniae while applying clinically relevant stresses based on my firsthand experience with the s pneumoniae cell cycle i hypothesize that many cell cycle regulatory mechanisms have been overlooked thus far because of their relatively low importance in optimal growth conditions which are rarely encountered in realityi will identify genes involved in such cell cycle regulatory mechanisms at a genomewide scale using an innovative approach i developed for this purpose in contrast to fitnessbased nonspecific readouts i will perform facsseq fluorescenceactivated cell sortingbased sequencing to select mutants in which specific cell cycle processes are altered based on appropriate fluorescent readouts after identifying the selected mutants i will characterize the molecular mechanisms involved and investigate their level of conservationmy research will substantially advance our understanding of how bacteria regulate their cell cycle when exposed to reallife stresses my results can therefore provide a starting point for the development of new antimicrobial therapies that target mechanisms important for growth in vivo given the emerging antibiotic resistance crisis such efforts are urgently needed
mirna regulation of developmental sodium channel isoform transition and its implications for dravet syndrome

dravet syndrome ds is a rare epileptic encephalopathy affecting 120000 children who suffer from infantile seizures and lifelong deficits in cognitive motor behavioural and social skills ds can cause premature mortality with up to 21 of patients not reaching adulthood despite the known genetic origin 80 of patients carry a mutation in the scn1a gene encoding the alpha1 subunit of the sodium voltage gated channel there is no cure for this disease the symptoms of ds start at six months of age shortly after the transition from the developmental nav13 scn3a gene to the postnatal nav11 scn1a channel isoform carrying the mutation the mechanism of this transition remains unexplained which hinders the nav13 isoformbased ds therapy i will build upon the recently discovered mirnas short noncoding rna regulatory effect on scn1a and 3a genes to elucidate regulation of the isoform transition my ultimate aim is to harness the protective effect of the nav13 isoform via mirna regulation as a ds treatment i will untangle the mirna profile of ds from birth to the symptom onset in a wellestablished mouse model through mirna expression manipulation i will resolve mirna function in scn1a and 3a regulation its impact on the brain and ultimately on ds symptoms my skills in developmental epilepsy models will combine with prof henshalls expertise in mirna function and use in treatment shown by mirnabased treatments for epilepsy in preclinical development to deliver novel treatment options for devastating ds and advance the field of mirna regulation in the brain this training collaboration with top neurobiologists at three excellent institutions rcsi host ua umcu secondment partners will advance my skills employability and propel my career in developmental neurobiology it will also contribute to the quality of europes research and innovation increasing its competitiveness and attractiveness as a leading research destination
predicting the fate of plastic on beaches by their 3ddistribution and weathering processes

recent global plastic pollution models predict that two thirds of the plastic mass released from land into the ocean since 1950s is likely to have stranded around the worlds shoreline yet our knowledge about the degradation burial and transportation fate of beached marine plastic debris mpd remains limited and little is known about the exact capacity of beaches to store mpd to fill in current knowledge gaps in global monitoring of mpd we propose a novel approach based on repeated fieldsurveys of surface and buried mpd and studying the physicochemical transformations induced by mpd aging on hawaiian beaches which are known hotspots for mpd due to their proximity to the north pacific garbage patch data collected from repeated surveys of surface and buried mpd on beaches will generate 3d maps of mpd and assessment of temporal mpd fluctuation and accumulation zones of mpd with respect to the type size and density of mpd present on the surface and in the sand column following the aging of plastic debris when stored on beaches will reveal dominating mpd transformations and rates including fragmentation rates which will provide key information eg changes in density buoyancy and fragmentation to model fate transportation and transformation of mpd in coastal environments we envision that outcomes from storage can timely provide scientific evidence supporting decision making within the present and future legislative measures against plastic pollution prompted by the eu and global agreements the interdisciplinary transfer of knowledge needed for storage will be facilitated through stays at the center for marine debris research cmdr at hawaii pacific university hpu in the us laboratoire structures matriaux avancs et sollicitations hyperbares smash at ifremer in france and a secondment at the research team at the ocean cleanup office in the netherlands and brings together key actors in mpd analysis and sampling plastic pollution modelling and polymer science