Dragon09/odtu_chatbot huggingface dataset:
molecules for nociceptor force transduction

pain results from activation of the nociceptive sensory system which is built upon the primary afferent nociceptor a type of sensory neuron specialized to detect code and relay information about potentially or actually damaging stimuli humans lacking properly functioning nociceptors never experience pain and have reduced life expectancy and suffer severe disability nociceptors detect sustained force into ranges that are potentially damaging and sustained nociceptor activation will always lead to pain it has been assumed that mechanical force transduced by nociceptors requires mechanically activated ion channels in the nociceptor membrane however recent data suggests that sensory schwann cells that wrap the nociceptor ending also participate in force transduction the aim of this proposal is to identify molecules specifically involved in nociceptor force transduction at this neuroglial site we have already identified an ion channel tmem87aelkin1 and an extracellular tether protein tenm4 as being involved in nociceptor force transduction in addition stoml3 modulates elkin1 function and can sensitize almost all nociceptors to mechanical force the identification of a set of molecules involved in force transduction elkin1tenm4stoml3 will allow us to design guilt by association approaches to identify new players we will use ultralow input spatial proteomics bioid and high throughput electrophysiological screening to achieve this aim we have designed novel genetic strategies to interrogate the function of candidate proteins in nociceptor force transduction with timescales ranging from weeks to minutes this ambitious and challenging project promises to deliver novel molecular targets that can be used to specifically target nociceptor force transduction specific targeting of nociceptor force transduction could be a powerful new way to treat multiple pain types poorly served by existing therapies
research intelligence and technology for heritage and market security

rithms project intends to boost the operational capacity of police and customsborder authorities in addressing the increasingly organised and polycriminal nature of trafficking in cultural goods through research technological innovation outreach and trainingillicit trade in cultural heritage has progressed from a local phenomenon limited to the initiative of a few individuals to a highly remunerative source of income for criminal organisations and terrorist groups that have taken advantage of the opportunities offered by the web and social media to further expand an already flourishing market against this background rithms proposes an interdisciplinary approach made necessary by the transnational character of this crime and its links to other criminal networks the project will define a replicable strategy to counter the challenges in addressing the illicit trafficking of stolenlooted cultural goods and to investigate the mechanisms underpinning it including its connection with organised crime rithms will foster crosscutting research bringing together all the domains relevant to expand the understanding of this type of crime art market criminology law studies forensic science etc inputs from these disciplines will inform the theoretical framework underlying an interoperable aibased platform able to identify criminal organised networks and to provide investigators with valuable intelligence on the activities and evolution of such networks the platform will be leveraging the methods of social network analysis sna a methodology that gives a way to better understand human behaviour through peoples relations and interactions including four police authorities two border agencies one police school smes and researchers from ssh and ict rithms consortium is well positioned to offer solutions to counteract more effectively organisations involved in illicit activities against cultural heritage
transformational and robust adaptation to water scarcity and climate change under deep uncertainty

worldwide water resources management is increasingly challenged by water scarcity and climate change which can trigger and aggravate other ecological eg pests and socioeconomic threats eg commodity price fluctuations via feedback loops and cascading impacts across systems in this context planning for the future is rife with uncertainties for which conventional decisionmaking methods and policies are inadequate the objective of transcend is to identify and catalyze the adoption of transformational adaptation policies tap to water scarcity including innovative allocation systems and economic instruments that are robust and adaptable to uncertainty and change while simultaneously achieving equitable and sustainable economic growth and welfare to this end transcend will develop a groundbreaking ecosystem of innovation that combines three key pillars i a knowledge network for stakeholder engagement and knowledge sharing ii an actionable modeling suite that integrates interdisciplinary socioecological science and ensemble forecasting to guide tap design and iii an accounting and monitoring toolbox that supports implementation and enforcement of tap in practice transcend will apply the ecosystem of innovation to design and implement tap in 7 labs jcar river basin rb spain reno rb italy tympaki rb greece nitra rb slovakia caplinamauridesaguadero rb peru chile bolivia orontes rb lebanon syria turkey and mahanadi rb indian states of chhattisgarh odisha transcend will leverage this diverse set of demonstrators to initiate adoption of the ecosystem of innovation in 8 inspiration labs train 160 transformation agents and mainstream uncertainty analysis in key national and european green deal strategies this will provide the knowledge and tools to catalyze robust and systemic transformations to water scarcity and climate change globally with a clear impact pathway towards tap adoption in 100 basins by 2030
regulation of articular cartilage zonal emergence harnessing developmental pathways to enhance regeneration

articular cartilage ac has a complex zonal structure and composition providing it with its essential functional properties however when cartilage is damaged the zonal complexity does not regenerate leaving an inferior tissue which is prone to degeneration as a result cartilage injury commonly leads to pain and the eventual need for joint replacement progress towards true regeneration of ac requires an advance in understanding of how zonal complexity and corresponding function emerge over development the most promising clue to understanding zonal emergence is that mechanical forces are known to be important for normal ac developmentrezone will reveal the mechanisms underlying zonal emergence through a novel goat model in which a common veterinary procedure is repurposed to create a radically altered mechanical environment in the developing joint by comparing gene activity between normal and altered states of zonal emergence i will identify pathways likely to be involved in zonal emergence i will leverage my expertise in cartilage explant culture and mechanostimulation bioreactors to develop a novel in vitro explant model and use this model to validate candidate pathways finally i will demonstrate the therapeutic potential of molecular regulators of zonal emergence using geneactivated biomaterials to regenerate zonal emergence in an in vivo largeanimal model of cartilage repairrezone will provide a stepchange in our understanding of how zonal ac develops postnatally including the role of mechanical loading the projects ambitious aim is to bring about enhanced regeneration of ac through activation of the developmental processes which form functional cartilage in early life revealing key mechanisms underlying zonal emergence in immature ac will enable true regeneration of injured ac improving quality of life for patients with articular cartilage defects worldwide
development and manufacture of new more sustainable and safer materials using biobased functionalised additives based on lingin and tannins to improve fire resistance

biosafire goes back to nature to upgrade lignins and tannins natures flame retardants and unlock them for industrial application of biosbased flame retardants starting from already existing pilot plants biosafire upscales and broadens the available feedstocks to provide flame retardant in powder formats for five applications in four different sectors naval railway home appliances and wood coatingsfeaturing the same fire retardancy performance as chosen toxic benchmarks and enhancing safety and sustainability with an 80 of biobased content biosafire aspires to not only demonstrate its targets on 5 use cases but also to create a material portfolio and a set of processing guidelines to enhance flame retardants substitution by the industry this will open the possibility for biobased resins to exhibit good fire retardant properties it will unlock a market opportunity worth usd 95 billion in 2028where europe involves a 25 share and the sectors involved in the project 65 of the market share biosafire will design an industrial pilot plant to understand and overcome value chain barriers and create a robust techno economic assessment to promote the market uptake of the project resultsbiosafire is an opportunity to test the eu jrc ssbd framework the project will use a tiered approach to run the framework iteratively and provide a decision support toolset link ssbd principles to early conceptual design and ultimately provide a software tool based on heu sunrise methodology the integration of ssh in the project will allow an enhanced social acceptance further boosted by the training materials developed during the project
womens criminality in the ottoman literary world 18601922

this project sketches a broader framework for the characterization of women offenders expression of women crime committing and their involvement as both victims and offenders in criminal cases not only in fictional narrations of ottoman literature but also in real cases that made news in the ottoman press i will critically address malecentric discoursing repetitive imputations stereotypical and clich wordy choices and reiterative vocabulary for the identification of female criminals by examining ottoman newspapers magazines journals and books from the late tanzimat period the 1860s up to the demise of the empire 1922 this work will mainly utilize feminist criminal approaches that follow iconoclastic ways to stand up against the systematic underestimation and negligence of androcentric crime theories and their effects on historical narratives these all restrict womens participation and involvement in criminal cases and identify female perpetrators without their criminal agency as a part of this understanding their voices as wrongdoers were mostly silenced in the ottoman press and literary works in this regard this study will especially dwell on women offenders who committed offenses contrary to their vulnerable fragile and sensitive stereotypical features all too frequently used as the reasons for the incapability of women to commit serious crimes succinctly the major goals of this project are to analyze the perspective vocabulary wording and conceptualization by the ottoman press and intellectual productions in the narrations of womens delinquency and the identification of criminal womens agency through literary criticism and to raise the voices of ottoman criminal women in real and fictional crime stories in the light of feminist criminal theory
metabolismyeatscrosstalk elucidating metabolic dependencies of epigenetic yeats action

metabolism and gene regulations act in concert to shape cellular identity and plasticity one major line of crosstalk occurs through metabolites such as acylcoas which are inscribed on histones as posttranslational modifications ptms to be subsequently recognised by reader proteins resulting in initiation of specific transcriptional programs the increasing identification of novel ptms necessitates thorough characterisation however still remain largely underexplored for instance the presence of nonacetyl acyllys ptms such as crotonylation with yeatsreader proteins identified to bind these ptms suggests complex gene regulation programs however despite the clinical relevance of yeatsproteins in various cancers little is known about their acylreading activity and transcriptional consequences therefore this proposal aims to close multiple knowledge gaps regarding overall function and mechanism of the metabolismacylptmyeats communication axis considering the metabolic context i furthermore propose epigenetic yeats action to be determined by direct interactions with metabolic proteins thus i will first establish an inducible yeatsdegradation platform to characterise the genomic context under various acylate conditions next i will implement a fluorescencebased cell reporter system which shall reveal putative interactors upon transfection with a crisprko library targeting metabolic enzymes lastly hits will be biophysically characterized their metabolic impact within the epigenetic context determined and codependencies on relevant cancer cell lines tested the interdisciplinary approach entailing stateoftheart chemical and molecular biology tools will be combined with highthroughput screening methods and bioinformatic analyses besides elucidating general principles of the metabolismyeats epigenetics crosstalk the results will provide valuable information for novel therapeutic avenues by exploiting identified codependencies
earthtomarinetoearth virtuous cycle harnessing residual biomass of animal origin for terrestrialmarine integrated circular economy one earth

one earth aims to develop and assess innovative biobased solutions for the production of nutraceuticalcosmetic bioadhesive agriculture fertilizers and aquaculture fish feed products by exploiting residual biomass of animal origin the overall purpose of one earth is to develop integrated circular value chains by valorising marine biomass for terrestrial products and using terrestrial biomass for aquaculture product production thus promoting a sustainable and selfreinforcing carbon cycleone earth will obtain polyunsaturated fatty acids pufas and polypeptides that make up nutraceuticals cosmetics and fish feed products through the transformation of specific residual biomass mainly using biotechnological strategies in particular cheese whey cw ie the most abundant liquid waste from dairy industries will undergo anaerobic acidogenic fermentation processes for the production of volatile fatty acids vfas which will be used as a carbon source for the production of pufas by culturing pure microbial strains a massive valorisation of cw carbon will be assured by exploiting co2rich gaseous streams from fermentation processes for cultivation of algae and further extractions of pufa moreover chicken feathers and fish scales will be processed using microbial and enzymatic approaches to obtain polypeptides while fishbones will be treated with a thermochemical innovative process together with organic residues from other project units to produce phosphorusrich fertilizersdedicated standard tests in significant environments will be carried out to evaluate the safety and quality of developed products consequently the economic environmental and social sustainability and viability of the whole proposed integrated circular value chain will be assessed the compliance with standards and regulations of developed solutions will also be considered to assess the project potential and opportunities to promote industrial initiatives and new business
biodiversity and transformative change for plural and naturepositive societies

biotraces develops knowledge tools and novel approaches that enable transformative changes tc necessary for achieving a nature positive society we aim to contribute to more inclusive effective and just public policies local strategies and corporate concerns on biodiversity aligned with the european green deal and sdgsto this end we will engage with diverse stakeholder networks around 9 transformative biodiversity innovations in highimpact sectors agriculture food forestry water and urbanisation these local case studies across europe will help understand in context how plural and often marginalized values identities intersectionality and knowledge systems concerning living with and caring for nature can shape behaviour the case studies will create a portfolio of good and failed examples by discerning power lockins leverage opportunities and enabling actors and by testing coproduced interventions also we will analyse indirect drivers of biodiversity loss structural factors and lockins that constitute barriers to sustainable decisions and behaviour a theory of transformative change totc will synthesise our findings showing steps on the path to biodiversity recovery and informing public and private strategies and approaches for initiating accelerating and upscaling tc biotraces originality is threefold 1 an approach of transdisciplinary collaboration based on action research coproduction and colearning 2 operationalising in research and action principles of pluralising acknowledging variety in values empowering enhancing agency of marginalised groups politicising unveiling the political dimension of obstacles towards tc and embedding bringing tc into the economy social practices and policy 3 a focus on achieving impact through a totc approach which led us to establish an influencer stakeholder board close alliance with the sciencepolicy interfaces and interproject collaboration suit our vision well
the social life of early medieval normative texts

solemne studies how ideas about social norms expressed in works of canon law spread throughout medieval western europe using an innovative digital tool to analyse the transmission of combinations of authoritative statements in canonical collectionscanonical collections are in essence compendia of rearranged authoritative statements canones drawn from a large body of authoritative texts as a genre that intersects with every aspect of medieval life and society rennie 2008 works of canon law in varying degrees of sophistication survive in a vast number of medieval manuscripts and address not only religious concerns but also social moral political and economic issues solemne is built on the premise that it is through the rearrangement of authoritative statements that medieval scholars articulated the changing medieval attitudes about social norms and societal idealssolemne aims to be the first largescale analysis of this dynamic process of appropriation and reorganisation of authoritative statements by developing a unique database and digital tool designed to identify and map the transmission of combinations of textual elements building on this innovative database solemne will study three central phenomena the medieval negotiation of canonical authority throughout the middle ages approx 5001200 ce to address individual objectives and specific contexts the compositional strategies to communicate social norms and ideals and the transmission of ideas through canon lawin addition to the wellknown grand collections solemne includes mostly overlooked canonical florilegia in its analysis expanding the breadth of canonical studies through its open access online presence solemne addresses the issue of the inaccessibility of canonical sources while its interdisciplinary methodology offers a wide applicability in the study of legal social political and intellectual history
maritime methanol adaptable renewable and environmentallyfriendly

the mare project develops and demonstrates a novel process for maritime methanol a new grade of lowcost green methanol based on biogenic co2 and renewable h2 to support the needs of the global shipping sector to reduce their co2 emissionthe highlights of the mare projectassessment and qualification of bioco2 from different sources biogas bioethanol pulp paper combustion for its feasibility in the methanol synthesis thus increasing the feedstock base for maritime methanolan improved methanol process using a new reactor system based on process intensification and a simplified methanol purification will be demonstrated the new process is uniquely suited to convert bioco2 compositions with fluctuating h2 supply to flexible grades of maritime methanol which will be further optimised in its composition and validated through a series of engine tests a digital model of the whole value chain from co2h2 to the maritime fuel will be developed to derisk the technology and boost its scaleup by assessing and optimizing different geographical scenarios as basis for the deployment roadmapmare is committed to deliver by mid 2027 a european maritime methanol process at trl 7 providing 80 co2 emission reduction compared to fossil maritime fuels and 10 tco savings compared to stateofthe art green methanol technologiesmare consists of a powerful and capable consortium with diverse expertises around the value chain air liquide as worldleader in methanol technology man as world leader for methanolfueled maritime engines and maersk as the worlds largest shipping company will provide industrial perspectives while academic partners from greece certh italy sssa pisa france lrpg and the netherlands tu delft will contribute with unrivaled scientific expertise in catalyst testing digital tools reactor simulation and life cycle assessment finally eta florence will guarantee toplevel dissemination of the project results
enabling stakeholdercentric zero emission ecommerce delivery and return practices through transparent and collaborative supply chains

while europeans can track and understand their personal transport emissions they have little to no information regarding the impact of their online shopping deliveries and returns this is due to a mix of challenges including the complexity of calculating emissions across the ecommerce supply chain and the limited regulatory levers public authorities have to influence greener practicesto overcome these challenges greenturn brings together a diverse range of ecommerce stakeholders to cocreate zeroemission logistics solutions provide sound and transparent information on ecommerce footprints and enable more sustainable delivery and return choices the consortium comprises 14 partners from 7 different countries and is further complemented by its stakeholder advisory board activated during key project momentsgreenturn uses design thinking approaches to develop solutions which bridge between behavioural interventions including incentives nudges and gamification and delivery and return options such as time windows instore pickups and returnable packaging among others to test solutions greenturn implements 5 complementary pilots involving 1 lsp 1 marketplace provider and 1 retailer as partners and 8 lsps 3 marketplaces 7 retailers as stakeholdersthrough the involvement of significant and diverse companies the project has potential to reach and raise awareness among 30m ecommerce consumers from 5 countries poland spain france greece and austria advanced logistics systems allow the five pilots to offer on average 82 of delivery and return options as zeroemissionbesides the greenturn pilots will touch upon social sustainability aspects too for both customers eg physical and digital accessibility and ecommerce logistics employees eg work conditions market reintegration etctogether with its public authorities greenturn will translate results into policies that can secure uptake and longterm impact