Dragon09/odtu_chatbot huggingface dataset:
intersubjective aidriven multimodal interaction for advanced usercentric human robot collaborative applications

to strengthen the competitiveness of the eu industry there is an increasing need for flexible production exploiting the capabilities of both the machinery and human workforce the growing market of robots has reacted adapting to the changing situation by providing collaborative robotic solutions with a variety of characteristics in terms of payload type and mobility a number of technological solutions for perception and safety allow their coexistence with humans while several research activities have been conducted over the past 5 years on this topic wider industrial adoption is lagging due to the following restrictionslimited cognition and intelligencelow performance of collaborative operationscollaboration fluidity is rather low as the operators have to adapt to the particularities of the robotscomplexity in robot programming which requires the involvement of skilled engineers does not provide flexibility in the execution phase and does not benefit from the tacit knowledge of experienced operatorsthus despite the fact the mechatronics are quite advanced a perfect matching of mechanics and control is required to create robots that advance from repetitive and precisionoriented tasks to becoming intelligent and helpful coworkers proper human robot interaction is the most important ground to be covered thus jarvis aims to develop a reusable set of tools that enable ai driven multimodal means of interaction a involving interfaces for physical and remote information exchange robot control and programming b providing social skills to a variety of robots to achieve seamless usercentric interaction that extends human ability for complex tasks and c demonstrating scalability of application and ability to achieve economies at scale
agents of geomorphic change in submarine canyons

submarine canyons are dynamic systems that are ubiquitous across continental margins and play a key role in the transport of material into the deep ocean this transport is primarily facilitated through submarine landslides and turbidity currents which can mobilise large volumes of sediment at high speeds across great distances while some submarine canyons are flushed by low volume turbidity currents multiple times each year others in similar tectonic settings remain inactive for multiple decades between highermagnitude canyon flushing events nonetheless such rapid change can dwarf the effect of other geomorphic processes such as biological erosion or bedform migration whose action over decades or centuries can bring about significant change in canyon morphology and also precondition slopes for failure subcan will make use of a suite of acoustic multibeam echosounder subbottom and seismic data and sediment cores as well as numerical modelling to investigate the agents that bring about change in submarine canyons over a variety of spatial and temporal scales this work has implications for understanding and predicting margin evolution and will provide important constraints on margin stability and hazards in particular subcan will i use repeat mapping and monitoring to quantify finescale geomorphic changes and processes over up to 25 years in two endmember submarine canyons one loweventmagnitude higheventfrequency system and one higheventmagnitude loweventfrequency system ii implement hierarchical reducedorder numerical modelling to model canyon evolution and stratigraphic change in response to the action of geomorphic processes on a marginscale using those two systems as end members and iii reconstruct geomorphic processes and evolution of a canyon where high resolution and repeat data are not available to reveal the universality of the key processes that bring about change in submarine canyons
unlocking the antitubercular mode of action of asperterpenoid through total synthesis

the rise of multidrug resistant strains of mycobacterium tuberculosis the pathogen responsible for the infectious disease tuberculosis calls for research into novel antitubercular scaffolds and targets asperterpenoid is a rare sesterterpenoid with a unique and highly complex 57365 ringfused carbon skeleton that strongly inhibits tyrosine phosphatase b a virulence factor protein secreted by m tuberculosis that aids human host infection to date total synthesis of asperterpenoid has not been accomplished we propose a modular synthesis of asperterpenoid from biorenewable sitolactone using a key intermolecular reductive titanium mediated giese addition reaction the scope of this privileged reaction will be expanded by investigating selected epoxide substrates and michael acceptors we anticipate that the synthetic strategy to asperterpenoid can be extrapolated to prepare variecolin a structurally related sesterterpenoid that has been subject of several studies but never reached by chemical synthesis based on its structural similarity to asperterpenoid we expect that variecolin will also exhibit antitubercular activity we plan to study the known antitubercular activity of asperterpenoid by structural diversification and its mechanism of action by a chemical biology tools such as molecular imaging we also plan to test variecolin for antitubercular activity the action is expected to contribute to new synthetic tools and strategies to prepare rare sesterterpenoid natural products a better understanding of the promising antitubercular properties of asperterpenoid and to demonstrate that variecolin exhibits similar bioactive behaviour
estatic soft sensors a study on applying industrial manufacturing techniques to develop selfpowered triboelectric textile sensors for highaccuracy activity recognition in smart homes

estatic soft sensors is an investigation into manufacturing selfpowered triboelectric textile sensors with regular materials for eg wool polyester and conductive yarns for highaccuracy activity recognition in smart home applications triboelectricity is generated when materials such as human skin and synthetic fabrics repeatedly rub together this form of electricity is considered annoying or can even be dangerous however when handled safely it can provide unique insights into our everyday interactions with textiles and present an environmentallyfriendly solution for sensing different kinds of activities for smart home applications such as fall detection for elderly care assistance in indoor navigation or sports tracking and game designrecent advancements in textilebased triboelectric nano generatorstteng have highlighted the rich potential of using this energy for powering lowpower devices however their sensing capabilities remain limited to a single repetitive movement additionally the current work in tteng present oneoff prototypes and are not at a stage where they can be manufactured on a larger scalewith an aim to tackle these challenges the project develops an approach for constructing highperformance selfpowered triboelectric sensors without the need for specialised materials using industrial production techniques of weaving tufting and embroidery these sensors will be evaluated and optimised for high accuracy selfpowered activity and gesture recognition by applying advanced textile construction knowledge to optimise the structures and using ai models to fine tune the sensing analysis additionally their tactile and interactive properties would be evaluated in order to improve their suitability and acceptance of embedding them in everyday usecontextsthe results of the project including the patterns files for the sensors would be documented online and shared openly for supporting reuse adaption or commercialisation
signature of sediment cascades following landslides triggered by extreme events in the stratigraphy

catastrophic sediment release in fluvial systems is largely driven by landsliding that occurs naturally during extreme events such as earthquakes or storms in mountain belts sediments cascade through the river system until they are stored either permanently in alluvial fans and lakes or temporarily in terraces to mitigate future landslide hazards it is urgent to better understand past extreme events such as their amplitude and frequencies which calls for an improved identification of a landslide signal in the stratigraphy the scalees signature of sediment cascades following landslides triggered by extreme events in the stratigraphy project aims to provide a calibrated and validated numerical model of multigrain size sediment transport and storage that will be apply to unravel the signal of landslides preserved in lakes or alluvial fans and in terraces to do so this numerical model that is a recent development of the established riverlab landscape evolution model will be parametrised using extensive and unique data collected in new zealand where coseismic landslides have heavily impacted landscapes the combination of empirical data with numerical simulations will allow us to predict for the first time the full signal all grain sizes of sediment cascades preserved in the stratigraphy in response to an extreme event at the scale of a catchment the project builds up upon the complementary expertise of the fellow in the field of numerical modelling of sediment transport and storage of the outgoing supervisor in sedimentology related to natural hazards and of the return supervisor in fluvial geomorphology through the access to a unique dataset of postearthquake records as well as scientific networks and the design of a detailed career development plan and a tailored training program the fellow will be provided with a unique skill set to become an internationally recognised geomorphologist ready to tackle interdisciplinary research questions
the next stent generation a firstinclass regenerative nanofiber stent to reconstruct arteries from the inside out

belowthe knee critical limb ischemia btkcli is the severe blockage of the arteries in the limb leading to reduced blood flow this condition currently affects over 35m people in the eu and us the current standard of care for btkcli is balloon angioplasty this treatment unfortunately has failed to show strong clinical outcomes around 40 of patients suffer from procedural complications 73 of the cases develop restenosis within 3 months and 25 of patients end up requiring minor or major limb amputations stentit has developed a firstinclass stent with regenerative capacity a paradigm shift for medical stents the regenerative stent is fully composed of nanofibers which allows for unique vascular restoration the stent gradually dissolves while new vascular tissue is being formed fully rebuilding the artery to secure longterm patency stentit requests a 25m grant and 10m in equity to complete the clinical studies and prepare the regenerative stent for market launch
switching european food systems for a just healthy and sustainable dietary transition through knowledge and innovation

the overarching goal of the switch proposal is to improve understanding of knowledge accessibility and facilitation gaps that limit present large scale adoption of sustainable and healthy diets among european citizens and to develop and demonstrate appropriate innovative solutions and tools to facilitate a just transition towards healthy and sustainable dietary behavior at all levels of the multiactor food system in euthe transition towards sustainable safe healthy and inclusive food systems from farm to fork has become a key priority for eu policies in line with the un goals sustainable development goals sdgs the biggest challenge at present is represented by the limited knowledge of influence dietary choices which limits large scale adoption of healthy and sustainable diets the switch ambition is to accelerate the behavioral shift of european citizens towards more sustainable and healthy patterns using research and innovation ri as a driver to increase knowledge accessibility and facilitation strategies at all level of the food systems involving a multiactor systemic approach and a cocreation strategy to delineate solutions fair to consumers that support virtuous behavior throughout the whole food chain for a successful large scale adoption of healthy dietary behavior all the actors of the food systems need to be engaged connected and valorized in pursuing its objectives the project aims to go beyond the present stateoftheart addressing the most relevant points of the program topic transition to healthy and sustainable dietary behaviour horizoncl62021farm2fork0115
structure and regulation of bacterial biofilmpromoting exopolysaccharide secretion systems

bacteria are commonly defined as unicellular organisms however they constantly exchange substances and information with their confrres and the environment and can efficiently shelter themselves and achieve homeostasis by building multicellular collaborative macrocolonies called biofilms members of these sessile communities can undergo significant functional differentiation and are typically embedded in complex extracellular matrix that secures both mechanical protection and a medium for intercellular exchange importantly the switch between sessile and motile lifestyles in pathogenic bacteria can correlate directly with the development of chronic vs acute infections whereas extracted bacterial matrix components can find a variety of beneficial biotechnological applications exopolysaccharides eps are a major biofilm matrix component and are typically produced by transenvelope secretion nanomachines many of which are controlled at multiple levels by the intracellular second messenger cdigmp here we will consolidate our expertise in biofilm formation cyclic dinucleotide signaling bacterial secretion and integrative structural biology to decipher eps secretion system assembly and function in several medically and industrially relevant species we will use complementary recombinant and in situ structural biology approaches together with established genetic and imaging techniques to decipher the molecular events controlling eps biogenesis from transcription initiation interdependent protein folding and cooperative subunit interactions through secretion system assembly formation of supramolecular secretory nanoarrays and eps modifications to harnessing the biosynthetic processes for the engineering of novel antiinfectives or beneficial eps superproducers over the last years we have spearheaded these studies by unprecedented mechanistic insights into several secretion systems and have demonstrated the feasibility of such an ambitious project
physiological bases of prosocial behaviors

social life is a mix of cooperation and competition a critical component of cooperation is proactive prosociality arguably contributing to the emergence of complex cognition recent findings in corvids reported similarities in the behavioral and cognitive levels between birds and mammals suggesting convergent evolution of sociocognitive skills this project aims to understand the development of prosocial behaviors and their underlying physiological mechanisms in two avian species carrion crows and ring doves the main premise of this project is that the brain governs both behavior and autonomic body responses thus autonomic biomarkers can be used to gauge brain activity during complex behaviors such as social interactions a newly established methodology will be deployed to continuously monitor autonomic biomarkers such as heart rate and body temperature in two or more interacting partners during forming alliances and cooperative affiliative and sexual behaviors the biomarkers will be used for longitudinal measurements of proactivereactive social behaviors during the sociocognitive development of crows to predict prosocial behaviors and individual differences in social integration altogether this research will contribute to the understanding of physiological mechanisms driving social behavior and bridge the gap between studies in animal cognition using a purely behavioral approach and invasive neuroscience methods to study brain circuits underlying behavior
mechanisms of human mrna packaging and export

the export of mrna from the nucleus to the cytoplasm is an essential step in eukaryotic gene expression this process requires that only fully processed mrnas are exported while undesirable rnas are degraded in the nucleus this selectivity is proposed to be mediated by the packaging of mature mrna by export factors protecting mrna from nuclear degradation and licensing it for export to the cytoplasm however this model has not been directly and thoroughly tested furthermore the full range of factors that promote the selective packaging and export of mrna is not yet knownin this proposal i propose an interdisciplinary and collaborative project that addresses these two major outstanding topics in gene expression to address the role of mrna packaging as a key driver of nuclear export versus degradation i propose to employ a timeresolved transcriptomics and modeling approach to simultaneously measure nuclear mrna export and degradation rates modulating mrna compaction state with rapid protein degradation next i will employ orftag a novel genomewide gainoffunction screening method that will determine the full list of proteins sufficient to drive nuclear mrna export i will then characterize promising novel export factors using transcriptomic and biochemical approaches to integrate these proteins into our structural understanding of nuclear mrna packaging the diverse methodology of this project the technical support both within the host labs and the facilities on campus and the high quality of training resources and supervision available will facilitate my own development as a scientist and prepare me perfectly to establish my own independent research group through my relocation from the uk to austria i will expand the european rna biology network forging future international collaborations my background in molecular and computational biology will allow me to execute this impactful project and answer fundamental questions in gene expression
surfaceenhanced raman spectroscopy in liquid biopsy for breast cancer

despite current largescale mammography screening programmes breast cancer is still the leading cause of cancer death in women in the vast majority of countries it is recognizable that cancer deaths could be prevented through earlier diagnosis and adequate treatment therefore new vigilant diagnostic tools that could provide an earlier diagnostic should be developed the progress regarding sensitive robust fast and costeffective biosensors is a very active research field surfaceenhanced raman scattering sers spectroscopy is a powerful technique for ultrasensitive labelfree analysis of chemical and biological samples with wide applicability vastly demonstrated for cancer nevertheless translation of sers to the clinics and industry is limited due to the lack of reproducible substrates and automation routines to analyze complex spectra liquid biopsy is the most commonly used practice for clinical preliminary disease screening some groups have already shown noteworthy work addressing the potential of sers in blood plasma and urine making it suitable for rapid and minimally invasive cancer diagnosis sers can be applied to sense subtle changes in composition and structure of biomolecules in plasmaurine from cancer subjects allied to this discriminant analysis models dam have been applied to sers these studies demonstrate that a powerful diagnostic system can be built for cancer screening with very high specificity and sensitivitythe main objective of siren is the development of a liquid biopsy test on which highly sensitive solid sers substrates will detect changes in biomolecular profile between cancer and no cancer samples blood plasma and serum and urine will be used in a labelfree detection combining with new developed clinical decisionsupport systems based on sers spectral analysis the project will provide a classification system for early diagnosis progression and breast cancer in patients
studying the cisregulatory changes that have shaped human evolution

while the phenotypes that set us apart from our closest extinct and extant relatives have been largely demarcated we are still far from understanding the genetics of human adaptation and how these changes affect our current anatomy physiology and health most human adaptations have likely occurred in regulatory regions particularly in cisregulatory elements such as promoters and enhancers however our ability to study cisregulatory evolution is limited due to the complexity of identifying cisregulatory changes and linking them to phenotypes we believe these limitations can now be tackled by merging several cuttingedge approaches primarily hybrid cells and massively parallel reporter assays mpras augmented by developing sorely needed new ones in aim 1 we will generate humanape hybrid cells and use them to identify the gamut of cisregulatory expression changes separating humans from other apes in aim 2 we will perform mpras to map the function of each of the variants that distinguish modern humans neanderthals denisovans and apes in aim 3 we will develop methmpra a novel method to map the role of dna methylation in shaping gene expression in aim 4 we will synergize these data to study human evolution at the sequence methylation expression and phenotypic level the proposed project will a generate comprehensive resources including the first catalogs of the sequence and methylation changes that shaped human gene regulation b develop a novel method to characterize en masse the ciseffects of methylation on expression c develop novel platforms humanape hybrid cells to map human cisregulation and d identify genetic changes underlying human traits together this will pave the way to understanding the role of gene regulation in human evolution
spatial quantum optical annealer for spin hamiltonians

optical simulators rank among the most promising candidates to power future technological breakthroughs in terms of speedscalability powerconsumption and quantum advantage serving a wide range of useful optimization problems however theoperation of such simulators remains currently limited by noise the extent of algorithmic problems they can embed and to theclassical regime where they compete with supercomputers heisingberg aims to bring our stateoftheart spatial photonic spinsimulator an iterated cycle of alloptical processing through a spatial light modulator that couples 10000 spins into the quantumregime by upgrading its coherent drive to squeezed light making it fully programmable through vectormatrix multiplicationschemes use of holography ancillary spins effective magnetic fields and designing dedicated customtailored and purposebuiltalgorithms the reduced fluctuations in one quadrature of the fields will allow us to scale up and optimize the performances of theexisting machine to bring it beyond the capabilities of both classical supercomputers and competing spinsimulators heisingbergdevices will operate 100000 spins at room temperature and process new quantum annealing algorithms on an improved xyarchitecture besides the nonclassical resources of squeezed states when modulated admixed and phasecontrolled through beamsplitters such as entanglement or superpositions of multiphoton states will be prospected to harness a quantum advantage andboost our machine into its quantum simulation regime this development will stimulate the quantum information processingcommunity by concretely articulating problems of algorithmic complexity and clarify the nature of the quantum advantage availablein annealers and simulators these advances will allow us to demonstrate on a cloud platform annealing and adiabatic algorithmsthat can efficiently solve nphard problems