Dragon09/odtu_chatbot huggingface dataset:
clean bioenergy for industry novel fuel flexible highly efficient and closetozero emission combined biomass gasification and combustion technology for industrial applications

cbe4i aims at the development of a novel fuelflexible biomass updraft gasification based technology for a highly energy efficient almost zero emission and zero waste process heat supply for flexible implementation at industrial settings satisfying the specific demands of industry lowvalue biomass residues which are available in large quantities shall be appliedcbe4i shall provide either i heat at different temperature levels which can be applied for indirectly heated processes via product gas combustion in an almost zeroemission gas burner with integrated threeway catalyst flexibly coupled with different boiler types hot water thermal oil steam or ii process heat and a clean product gas via product gas extraction with integrated thermal and catalytic tar reforming for utilisation in gas burners for direct heating a novel flue gas condensation concept with directly coupled heat pump shall boost efficiency up to 120 related to the ncv of the fuel a newly developed condensate treatment shall allow for a direct discharge into sewers and regarding ash utilisation a new concept for application of biomass ashes in fertilizer production shall be developed moreover cbe4i shall include the necessary fuel pretreatment technologies and fuel logistics suitable for industrial sites the latter comprise space saving onsite fuel logistics and online fuel quality assessment based on a new intelligent crane system the methodology applied to reach these goals relies on technology development tasks based on process simulations cfd aided design of the single units test plant construction performance and evaluation of test runs a technology assessment part covering risk assessments lcas technoeconomic environmental and overall impact assessments as well as targeted dissemination activities a market study shall investigate and define the framework conditions and application potentials of the cbe4i technology in different industrial sectors
the first universal and priceneutral insulin pen

the challenge for many people with diabetes pwd is that they dont get the right dose of insulin at the right time this can potentially give long term health issues and even shorten their lifetime today this is an everyday challenge for more than 13 million people that still inject insulin with a 100 years old outdated technology syringes and needles and cannot afford branded insulin and modern pens gopen aps developed the 1st affordable safe and sustainable insulin injection system that fits the unmet health needs in the worlds most resource constrained population the unipen system innovation relies on the possibility of refilling a disposable cartridge with any kind of insulin available resulting in a costcompetitive device to syringes solution improving the accuracy now with the support of the eica funding we intend to refine the design of the unipen device demonstrate its design and clinical usability and finetune the scaleup production
understanding inkt cell metabolic features in glioblastoma tumours to improve immunotherapy

glioblastoma gbm is one of the most aggressive and fatal types of tumours with one of the worse survival rates although immunotherapy is a remarkable and fastgrowing field on cancer treatment it still faces the challenge that solid tumours are very suppressive for immune cells this suppressive tumour microenvironment tme is known to affect immune cells in different ways as through the expression of inhibitory ligands and cytokines recently it has been shown that lipids and other metabolites are increased in the tme and affect metabolic pathways in immune cells leading to their dysfunction nkt cells are a distinct subset of lymphocytes that react to lipids presented via the cd1d molecule and produce a range of cytokines upon activation they play a role in tumoral immunity either through cytotoxicity or by activating other cytotoxic lymphocytes however little is known about their function in the gbm tumour and how the tme affects it this project will leverage expertise in immunometabolism to describe the alterations in nkt cell metabolism that lead to their dysfunction in the gbm tme we will take advantage of singlecell metabolic tools and proteomics analysis to unveil the most altered pathways then set up the best approaches to engineer nkt cells and make them resistant to the adverse tme our findings will potentially pave the way to new strategies on engineering immune cells for cancer immunotherapy and other serious conditions
development of antimicrobial antiviral and antifungal nanocoatings for everyday surfaces

since the end of 2019 the spread of covid has deeply changed our lifestyle resulting in historical events and decisions such as the eu block of nonessential travel among countries comm 2020 499 affecting the whole eu society economically and psychologically however as reported in the hera target priorities the persistence of the emergency status requires daily actions that tackle the spread of covidin this economical societal and clinical context the project miria aims to develop widerangeantimicrobial nanocoatings to be used in hospitals and other environments where crosscontamination and contagion risk are significant issues in the wake of the covid outbreak there has been large concern about infection spread of pathogens ie bacteria fungi virus and specifically sarscov2 via high traffic surfaces ie medical equipment state of the art and commercial products coating solutions that both target a range of mixed pathogens and different surfaces eg glass metal textile are unfortunately scant miria solutions aim to fill this void impacting on eu health both directly by creating public safe environments and indirectly by reducing covid spreading and decreasing illrelated work absences and psychological pathologies a reduction of the work absence of at least 5 with respect to the 2020 value 15m in eu is expectedmiria main challenging ambition is to develop nanocoatings with a 9999 effectiveness against a wide range of pathogens especially sarscov2 this will be based on a four pieces puzzle the knowledge in antimicrobial materials nanopowders nanocoating and pilot plant conduction these nanocoatings will be brought to pilot scale trl6 and within 3 years after the end of the project they are foreseen to enter the market trl9 the exploitation of miria outputs deeply involves smes and the dissemination plan will follow a spillover strategy in order to involve public and private stakeholders
causes and consequences of aberrant mrna translation in cancer

shortages in amino acids are weapons in the warfare between tumor cells and tumorinfiltrating lymphocytes tumor cells enhance or inhibit the production of key amino acid metabolites to stimulate oncogenesis and suppress antitumor activity a key player in this battle is tryptophan activated t cells secrete interferon which upregulates ido1 enzyme to catabolize tryptophan to kynurenine in target tumor cells while kynurenine suppresses tcell function its production limits tryptophan availability in tumor cells importantly as tumor cells almost invariably deregulate mrna translation to promote proliferation and metastasis the consequences of tryptophan shortage are major it provokes aberrant mrna translation at tryptophan codons resulting in ribosomal frameshifting and tryptophan to phenylalanine wf codon reassignments substitutants this aberrant mrna translation alters protein function and enriches the landscape of neoepitopes at the surface of tumor cells based on these observations i hypothesize here that the detection of aberrant proteins in cancer specimens can reveal additional key processes of cancer progression beyond tryptophan that can be utilized for cancer therapy to explore this exciting new idea i designed three work packages wpswp1 will expand the landscape of aberrant mrna translation in cancer and link them to cancerous events preliminary results pinpoint arginine histidine and leucine wp2 will generate reporter assays set up functional genetic screens and identify validate and explore key regulators of aberrant mrna translationwp3 will study the functional consequences of aberrant mrna translation and introduce novel therapeutic conceptsaltogether this proposal will employ our recent discoveries of aberrant mrna translation during periods of amino acid shortages to explore novel interplays between cancers and their suppressive microenvironment and utilize this new knowledge for cancer therapy
political lotteries in european democratisation

political lotteries randomly select individuals to take a political decision recently lotteries have put citizens together to find solutions to todays contentious polarizing issues such as disaffection abortion reform and climate change what explains their varied success lotteries equalise opportunity of access to all random chance can strengthen those otherwise in the minority a wider variety of opinions can also improve debate and reduce polarization the ideal but unfeasible experiment would randomly vary group characteristics assign real political power and observe effects over time instead this project draws lessons from past experiments during democratisation in europe whereby legislators were randomly assigned to groups within legislatures and experiments with lotteries in online citizens assemblies today lotteries ensured that minorities participated in deliberation in small groups and were assigned influential legislative tasks these natural experiments with lotteries have never before been investigated using modern statistical methods and their role in opening access to politics is almost entirely absent from empirical studies of democratisation this project compiles a novel comparative dataset of these political lotteries legislators parliamentary activity and offices from different european countries next the decisions of randomly assigned groups will be analysed within each natural experiment a theory of debate in randomly drawn groups reducing polarization will be verified by crossnational comparison across experimental contexts and in a presentday experiment that allows controlled conditions by opening access to minorities and contributing to strong deliberative party and committee systems lotteries stabilised political conflict they have the potential to do so again today the research will help inform evidencebased innovation of our representative democracies as experiments with lotteries have already begun
nanofluidic catalytic reaction imaging

how can we see a catalytic reaction on a single nanoparticle while our eyes use visible light to create a vivid perception of our world they are unable to resolve the nanoscale now imagine light yet allowing us to equally vividly see a chemical process and thereby enabling us to witness how structure or chemical composition of a single nanoparticle control the rate of a catalytic reaction on its surface to date the lack of a suitable technique prevents this ultimate level of insight at technically relevant conditions at the same time to gain such insight is the ultimate goal of catalysis science and a key enabler for the rational design of nextgeneration catalyst materials needed to address some of humanitys grand challenges in the energy environmental cleanup and health sectors nacarei therefore develops a nanoimaging method that realizes this ultimate goal as the key ingredients for achieving the necessary unprecedented resolution it relies on the combined nanoconfinement of reaction products in and the ultrahigh optical sensitivity of nanofluidic structures particular focus will also be put on the development of methods to fabricate or trap size shape and compositioncontrolled single sub10 nm metal nanoparticles inside nanofluidic channels by combining key traits of topdown nanofabrication and colloidal synthesis the developed nanoimaging platform will be applied to scientific case studies related to catalyst function with respect to the roles of particle structure surface state chemical composition and interaction with the support and thereby uncover the next generation of catalyst design rules in the long term i envision the developed nanoscale imaging platform to enable the study of other nanoscale processes for example in biochemistry thereby enabling high impact also at other vibrant scientific frontiers
quantum grenoble doctoral programme

the application of quantum phenomena to the development of new technological applications is one of the challenges of this century as it promises to revolution citizens lives on communication sensing computation and security quantum technologies are a priority of european and national stakeholders in order to secure european technological sovereignty in this highly strategic field as renowned actor in quantum science and technology universit grenoblealpes is proposing a cofund dp aimed at efficiently train research fellows in this emergent domain facing short to longterm challenges and to build their career perspectives with various track options short to mediumterm positions in private employment market where the need of several thousand jobs profiles in quantum topics is expected to emerge in the next eight years and in renown research centres all across europe fellows will be at the forefront of emergent quantum discoveries from fundamental science to novel technologies in a 3i ecosystem with perspective to diversify their set of skills and forge new mind sets and approaches to research and innovation quang will rely on the strong basis sets by previous cofund enabling fellows to be rapidly recruited using robust efficient fair and transparent recruitment and integration process and immersed in excellent training and supervision conditions both from research and transferable skills perspectives besides quang will aim at including all types of minorities and will strongly encourage women applications 30 associated partners academics and industrials and 17 laboratories are supporting uga in pushing forward this ambitious project that will recruit 36 phd fellows over 4 calls for a duration of 5 years uga consortium will invest 60 of the total funding available to fellows noticeably covering research training communication and selection costs
future enabling technologies for hydrogenpowered electrified aero engine for clean aviation

flyeco will deliver transformative technologies to support integrated power and propulsion systems ipps that contributes to zeroemission and sustainable growth of aviation and has the potential to enable aviation climate neutrality by 2050 the utilization of hydrogen as sole energy source offers the opportunity to eliminate aviation co2 emissions entirely furthermore a reduction in nox emissions of at least 50 is enabled by ingesting steam produced by a solid oxide fuel cell sofc into the hydrogenfuelled gas turbine gt flyeco will develop a simulation and evaluation framework in which the optimal architecture definition of the ipps the key enabling integration technologies and necessary controls concepts can be explored investigated closely and advanced towards trl3 through proofofconcept poc demonstrators a commuterregional aircraft application was chosen as a use case to develop the propulsion system with more than one megawatt power in particular the energy management and distribution strategies will be developed for both quasisteadystate and transient operation in addition poc for the ipps and the reduction in nox emissions will be provided via two demonstrators 1 a substructured testrig emulating the cycleintegrated hybridelectric propulsion system and 2 a highpressure combustor with steam ingestion the outcome of flyeco will be comprise ofan advanced simulation platform to analyse the impact of the sofc integration on a hydrogen gta validation methodology for novel energy and power management strategies for the ipps architecturea controls approach for the ipps including specialised local control for components and subsystems as well as global controla set of key coupling technologies develop developed to enable the integration of the sofc with a gt under consideration safe design process in aviation based on arp 4754a an openaccess database on hydrogen combustion with steam injection
highthroughput synthesis and characterisation of metalorganic framework thin films for volatile compound sensing

metalorganic frameworks mofs offer the possibility to tailor their nanopore environment and capture only specific molecules making them an ideal candidate as a receptor in gas sensors in order to mimic human olfaction several receptors with different selectivity toward volatile organic compounds vocs are combined in an array of sensors to form a socalled electronic nose enose highquality thin films of mofs are required for their integration in these sensor arrays however their synthesis has proven challenging due to a large number of parameters that influence the film qualityin the libmof project a highthroughput ht synthesis method will be developed to screen the synthesis conditions for mof thin films the ht approach will be about 25times faster than conventional synthesis and produce about 100times less chemical waste in addition with the developed method it is possible to deposit multiple different mof films on a single substrate which enables the use of ht characterisation of the functional performance dielectric properties adsorption isotherm and diffusion measurements of volatile organic compounds vocs the synthesis conditions of the selected mofs and their functional properties will be gathered in socalled libraries these libraries will also contain negative results and will be shared publicly to facilitate faster development of mofbased electronics finally an electronic nose composed of an array of chemicallydiverse mof sensor elements will be fabricated and evaluated for sensing of complex voc mixtures in realworld applications targeting indoor air quality monitoring and human breath analysis for disease diagnostics
creating synergies in widening countries on the topic of lowvoltage grid management

syngrid project aims to enhance institutional and regional innovation in widening countries through the capitalisation of outcomes from completed horizon 2020 and ongoing horizon europe projects the combination of valorisation of research results with the focus on enhancing the management observability and controllability of lowvoltage grids considering the increased integration of renewable energy sources will be combined with the transparent sharing of the knowhow to foster stronger collaborations between renowned research and innovation institutions and he beneficiaries in croatia greece and slovenia the outcome of the international collaboration will be materialised in a joint erdf he and life project proposals that will aim to bridge the gap between european and regional funding mechanismsto unlock the full potential of ri actors the syngrid project will employ a multifaceted capacitybuilding strategy supported by a comprehensive analysis encompassing a review of validated research outcomes from horizon projects and an assessment of the current technology landscape in croatia greece and slovenia to identify areas requiring intervention syngrid will engage key stakeholders including dsos regional authorities smes in the energy sector and research institutions the backbone of knowledge sharing is structured around key projects like h2020 compile and xflex as well as he stream and opentunity where partners served as coordinators or technical coordinators offering advanced insights into the topic of optimised grid reinforcement and advanced controllability to enable large share of res in the existing congested dso grid together with algorithms for fair sharing of limited capacity
active reduction of noise transmitted into and from enclosures through encapsulated structures

to better reduce exposure of people to noise and increase their acoustic comfort innovative noise barriers should be developed the overarching aim of innova is to provide a toplevel training for 10 doctoral candidates dc msca fellows plus 3 dcs funded by uk supervised by ucl 1 dc and uos 2dcs in a wide variety of cuttingedge noise control technologies developing a new generation of creative and entrepreneurial innovators the dcs will benefit from a unique softskills training programme that will kickstart their careers as highly employable professionals to reach these goals innova has pooled the interdisciplinary complementary and multisectoral expertise of leading research universities and innovative global companies in the fields of acoustics vibration materials engineering signal processing and control sciences represented by outstanding researchers and practitioners all srs will get strong intertwining academic and nonacademic supervision to jointly develop novel complete concepts for innovative barriers to reduce noise transmitted into and from enclosures through encapsulated structures dual problems thus creating a more pleasant and healthier local soundscape in workplaces and leisure areas as well as in car and aircraft cabins they will use structural design destructive interference of waves holistic approaches to soundscape forming metamaterials and employ advanced combined active novel passive and semiactive technologies the innova research training and outreach activities will have an important and lasting impact on the dcs members of the consortium individual people society environment international scientific community industry policy makers and on the eu as a whole it will propose first standards and labelling rules for active noise control systems it will also make possible reduction of mineral resources and energy consumption due to reduced weight of the structures the project is fully consistent with eu who and unesco policy declared in numerous acts
nearearth objects forcast of collisional events

the modern world is subject to many natural manmade and social dangers many of them are global in nature as they threaten the very existence of human civilization notable among them is the danger of earth collision with space bodies of cometary and asteroid nature at present there is no doubt about the importance and urgency of this problem in particular this is evidenced by a report of the national science and technology council usa where the importance to detect and characterize the nearearth objects noe population and to prevent and respond to neo impacts on earth is outlined to protect our planet from the dangers of collision with small bodies it is first of all necessary to understand from which specific of almost 1 million bodies the earth needs to be protected the project aims to make a system to search for possible threats to the earth from space bodies which will be independent from the ones that are now being operated in nasa and esa my project neoforce has several objectives 1 develop new methods for estimating of the impact probability of a small body with the earth 2 develop methods for obtaining more reliable estimates of orbital parameters and their uncertainties 3 make a search for old observations of known objects several webservices at the institut de mcanique cleste et de calcul des ephmrides paris observatory will be launched that will include 1 list of potentially colliding with the earth asteroids and comets with their impact probability values 2 list of possible close encounters of asteroids and comets with the earth 3 list of old observations made on photographic plates many years ago even centuries with the identifications to the objects imaged on them