Dragon09/odtu_chatbot huggingface dataset:
comparativehistorical analysis of the clausal structure in reefssanta cruz languages

the objective of chaoclrsc is to fill a significant gap in the history of oceanic languages by providing a comparativehistoricalanalysis of the clausal structure in the reefssanta cruz rsc languages spoken on the reef islands and santa cruz sc despite beingclassified as oceanic rsc show unexpected features including unusual patterns of clausal structure in particular iwoo displays asymmetrical voice system a type of clausal structure which is highly unusual in the oceanic family in this respect iwoo differssignificantly from the other rsc languages in that like most oceanic languages they display transitivitybased systems the presenceof a symmetrical voice system in iwoo is of interest for the history of the oceanic subgroup since voice systems are thought to havebeen lost in the transition from protomalayopolynesian pmp to protooceanic poc recent studies on iwoo and sc systems haveshown that the two systems are unusual in two different ways iwoo can be seen as transitional because it retains a symmetricalvoice system with oceanic morphology whereas sc languages retain some voicelike characteristics in otherwise largely transitivitybased systems historically the change from pmp to iwoo represents one stage of development from symmetrical voice to theoceanic transitivitybased system while the differences between iwoo and sc may represent a further stage this makescomparativehistorical work on sc clause structures an urgent priority more broadly understanding how the shift from a symmetricalvoice system to a transitivitybased has happened in rsc will contribute to our understanding of the general principles governingboth individual systems and more generally the change from one clausal system to the other
innovative functional oxide materials for green hydrogen energy production

the hgreen project aims to address the global energy crisis by advancing pioneering technologies and materials in the photo pyro and electrocatalysis of water splitting the project will leverage the unique properties of functional oxide materials to facilitate the costeffective production of green hydrogen through water splitting aligned with climate objectives in europe the consortium consists of fundamental research organizations and industrial companies with the expertise needed to solve this critical problem our research partners include the university of picardie upjv france and the joseph stephan institute jsi slovenia as well as the applied institute for ceramic technologies and systems at fraunhofer society germany two industrial companies nanotech ukraine and sterimed morocco are also part of our consortium through secondments and knowledgesharing training well equip a new cluster of material scientists with the skills and expertise needed to develop hgreen technologies that will power the world sustainably
creating inclusive learning environments socially and physically for all children an affordancebased approach

21stcentury european society is dynamic and heterogeneous characterised by cultural diversity resulting not only from migration but also widening acceptance of diversity in sexual orientation gender cognitive motor and neural capacities architectural and urban designers educational institutions and local agencies are called to offer a healthy inclusive and permanently adaptive environment for all members of this society the present study aims to develop an intervention model for advancing social interaction and inclusiveness in schools schoolyards playgrounds and similar parts of the built environment it follows an affordancebased approach that supports a better understanding of the fit between the built environment and the people who use it to inform inclusive design approaches using a bottomup approach based on stakeholders input we integrate insights from different disciplines to develop test and apply an intervention model based on information synthesised from behaviour mapping tracking observations and questionnaires this multidisciplinary approach delivers a comprehensive multifaceted perspective on individual behaviours physical activities social interactions and space usages for creating inclusive social settings designers schools and local authorities can use the intervention model to improve facilities activities and spaces so all children feel safe accepted and free to participate increasing social mental and physical health
neuronal computations and population dynamics in the cerebellar nuclei during motor behaviours

motor control involves many brain structures handling different behavioural aspects such as planning learning and execution of movements in vertebrates while downstream structures such as motor nuclei in the brainstem seem to encode simple stereotyped movements other structures such as the motor cortex seem to encode higher level aspects of motricity such as goal oriented complex movements the cerebellum a key structure for movement coordination and motor learning is extensively connected to higher structures such as the neocortex but also to brainstem nuclei controlling simple movements how the cerebellum influences downstream structures depends on the computations occurring in its output layer the cerebellar nuclei cn which integrates information from the cerebellar cortex and from extracerebellar inputs however these integration mechanisms and population coding in the cn are not well understood because technological and experimental difficulties have limited the study of cn processing rules both at the cellular and at the population level cerecode will address unanswered fundamental questions that undermine our understanding of cerebellardependent motor control 1 what is the functional connectivity in the cn network and how are sensorimotor inputs from different parts of the brain integrated 2 how are cn sensorimotor computations represented at the population level are there functional modules controlling stereotyped movements or are different tasks encoded within the same population 3 what is the individual role of the different extracerebellar inputs during behaviour cerecode will address these issues combining recent discoveries in cn neurophysiology viral strategies optogenetics and a new imaging tools that i developed based on 3dtwophoton acoustoopticlens imaging and grin lenses shining light on the neural code of an essential brain structure
metabolic regulation of genome function and cell identity

nuclear aims at educating future experts that can drive the emerging field of metabolic regulation of genome function and cell identity relevant for stem cell biology and cancer it is a doctoral training network composed of 14 beneficiaries and 12 partner organisations including three industrial partners a trainingoriented foundation a patient support association from 8 eu member states 1 associated country and a noneu member state selffunding itself to the level of beneficiary given the highly interdisciplinary nature of this emerging field no single institution can provide all suitable infrastructures and the knowhow required for highquality phdlevel training to address this shortfall in training capacity nuclear brings together european leaders in metabolomics functional genomics chromatin regulation stem cell biology and cancer with innovators in precision nutrition mass spectrometry technologies and drug development together we are committed to the following1 to train 16 doctoral candidates dcs through an innovative program structured in four capacity axes and occurring on three complementary levels to deliver enabling scientific and transferable skills2 to guide dcs in collaborative research bridging boundaries of countries sectors and disciplines3 to address three key challenges that limit the advancement and exploitation of the field and that are the lack of tools to measure nuclear metabolism the lack of understanding of underlying molecular mechanisms and the lack of targets for novel cancer therapies 4 to build lasting infrastructures for dissemination communication and exploitation promoting an entrepreneurial culture and maximizing and extending the impact of this proposal beyond its lifetime 5 to increase the international visibility of european research by taking leadership in the emerging field of metabolic regulation of genome functions and cell identity
psychosis risk subtypes and white matter integrity exploring subgroup trajectories

psychotic disorders rank among the top 25 global causes of disability impacting individuals their families and society much of this burden stems from early onset and poor clinical outcomes while approximately 30 of individuals experience persistent symptoms illness trajectories following a first psychotic episode vary widely and remain poorly understood cumulative genetic and environmental risk exposures and underlying white matter wm microstructure abnormalities have been associated with clinical outcomes during the first few years following psychosis onset still it remains unexplored how different combinations of risk exposures are linked via wm microstructure with short and longterm psychosis outcomes thus riskmatter aims to identify biologically and clinically meaningful subgroups of individuals with recentonset psychosis based on their different genetic and environmental risk profiles by employing advanced clustering approaches i will assess whether stratifying participants into these more similar subgroups enhances the effectiveness of supervised machine learning models that utilize wm microstructure and baseline clinical features to predict traditional oneyear clinical outcomes yet traditional retrospective assessments to evaluate clinical outcomes are prone to memory and assessor bias hence i will further recontact a subset of individuals up to eight years after psychosis onset to collect traditional and smartphonebased assessments to determine whether my models predictive accuracy is robust when evaluating longerterm and reallife outcomes during this project i will build expertise in diffusionweighted imaging unsupervised machine learning and smartphonebased assessments mentored by prof pasternak harvard medical school and prof koutsouleris ludwigmaximilianuniversity these skills will bolster my academic profile as a neuroscientific psychologist and facilitate my growth as an independent research group leader
nutricosmeceutical valorization of porphyrapyropia spp rhodophyta biorefinery approach in the frame of blue economy

nutricosmeceutical develops products to improve health through the use of bioactive compounds bacs algae are organisms that have a wide variety of bacs high productivity and can be produced without irrigation or arable land following eu green deal and blue economy the proposal aims to increase the macroalgae porphyrapyropia productivity in consortium with fish to produce high value bacs naturally and make nutricosmeceutical more attractive to the market to reach this objective the project will focus in porphyra production on a large scale using integrated multitrophic aquaculture with fishpond effluents from chelon labrosus for alga growing optimizing natural production of bacs extract and purify bacs through biorefinery strategy perform bacs encapsulation and test their sun protection stability toxicity bioavailability and develop topical and oral sunscreens researches shows some abiotic factors for bacs development and production in porphyra however there is a lack of studies that correlate various abiotic factors along with fish culture for a circular economy and better algae development the project will produce biofertilizers and biostimulants from residual algal biomass after extractions which has not yet been optimized natural sunscreens are still scarce on the market due to the lack of standards in extracts with stability for use in products and low bacs availability the projects interdisciplinarity is strong involving aquaculture biochemistry biotechnology and nutricosmeceutical this 24month long proposal includes both the transfer of knowledge to the host institution and the researchers training in new techniques furthermore this project will place the researcher and the host institution in a leading role on natural production of porphyra and bacs with emphasis in nutricosmetical industry it will make the researcher more employable and competitive in applying for future roles continuing in academic andor industrial area
multifaceted climate adaptation actions to improve resilience preparedness and responsiveness of the built environment against multiple hazards at multiple scales

as climatic conditions are constantly changing and the frequency of extreme events increases there is an urgency of planning designing and retrofitting the built environment in order adapt it to present and future risks too frequently the built environment is a driver of vulnerability rather than being a shelter for citizens for this reason mitigation and adaptation need to be pursued actively putting built environment and human resilience at the center of a climate and futureproofing action the multiclimact project aims to develop a mainstreamed framework and a tool for supporting public stakeholders and citizens to assess the resilience of the built environment and its people at multiple scales buildings urban areas territories against locally relevant natural and climatic hazards and supplychains as well as to support them to enhance their preparedness and responsiveness across their life cycle the mainstreamed approach will include a method specifically targeted for including several types of built environment assets including human wellbeing health and quality of life as an essential scale of analysis and action multiclimact will support resilienceenabling actions by implementing a toolkit of 18 reliable easytoimplement and costeffective design methods materials and digital solutions enabling users to easily estimate the impact of their implementation on the resilience of the targeted asset integrating a multidisciplinary approach integrating socioeconomic life engineering and climate disciplines the multiclimact approach is integrated with relevant international and european initiatives building upon existing knowledge and instruments and demonstrating the proposed approach in four case studies that represent various geographical location natural and climatic hazards social and economic systems and scales of analysis ranging from single buildings including cultural heritage to the urban and territorial scales
advancing circular economy with biobased solutions for co2 nitrogen management valorisation

acorn researches and develops business models for the commercial and industrial adoption of biobased products within the carbon dioxide and nitrogen management and valorisation portfolio cdnmvp using approaches that are compatible with a circular economy
romani chords uncovering romani practice for harmonic accompaniment with sonic visual and ethnographic analysis

the phrase romani chords rc encapsulates the distinctively lush harmonic language of romani musicians in slovakia this musical feature is key to impressing nonroma audiences and something roma consider a root of their entire musical culture rc are not merely a sonic phenomenon though they reflect longestablished economic practices in romani professional musicmaking skills in creatively reinterpreting music of the surrounding nonromani majorities and a particular form of musical learning whereby folk knowledge passes from generation to generation romchords is the first project that tackles this phenomenon in its anthropological and ethnomusicological complexity the project is an interdisciplinary investigation approaching rc as three types of data a sonic b visual and c ethnographic the main ambition is to challenge the primacy of western theories of harmony and to reconsider rc from the romani perspective unearthing how roma themselves perceive conceptualise and theorise their chords the project aims to answer the following key questions what role do rc play in the performance of romani ethnicity what is the significance of rc for romani professional musicianship how do roma learn rc and how do they innovate them and what is the role of vision in learning and teaching rc action to address these questions is shaped by three specific objectives which will be pursued through international and intersectoral cooperation between three participating institutions i data collection concerning rc among romani musicians in slovakia institute of ethnology and social anthropology slovak academy of sciences ii transdisciplinary analysis of the data employing methods of qualitative social sciences and computational ethnomusicology institute of ethnomusicology center for studies in music and dance portugal iii integration of knowledge about rc into a museum exhibition the museum of romani culture czech republic
employing the natural genetic variation to improve nutritional properties and stress tolerance in vegetable crops

yield and nutritional properties of vegetable crops are affected by unfavorable environmental conditions such as drought salinity extreme temperatures and pollutants this project aims at improving stress tolerance of major vegetable crops and design new strategies for maintaining higher yields and food quality even during unfavorable weather conditions one of the major research directions is exploring the wide genetic and phenotypic variations of fleshy tomato pepper and leafy lettuce vegetables to improve agronomical traits under abiotic stresses eg drought salinity and extreme temperatures we will employ a suite of genetics and genomics approaches such as gwas in combination with qtl to identify genes contributing to high yield and stress tolerance in another research direction we will characterize the fruit metabolic compositions in terms of flavor and healthy related compounds to assess the impact of abiotic stress on fruit quality a wide range of plant phenotypic and metabolic traits will be evaluated followed by transcriptomic profiling in two genomewide association gwas panels and two backcrossed inbred lines bils populations for both tomato and pepper the identified genes will be subsequently validated by crisprcas9 editing technologies and field trials to implement this ambitious work program a new research department crop quantitative genetics will be established in the center of plant systems biology and biotechnology cpsbb in plovdiv the new research department will scale up the applied research on vegetable breeding in cpsbb and the region furthermore the new cpsbb department will link with bulgarian and international research organizations companies and farmer associations in the field of crop science creating an ecosystem network that is highly attractive to talented researchers and brings the innovations to end users for the benefit of the society
molecular mechanisms for hostmediated metal poisoning detoxification in mycobacterium tuberculosis

mycobacterium tuberculosis mtb the causative agent of tuberculosis tb kills 15 million people every year major challenges facing tb eradication are the lack of effective and affordable treatments the slow pace of innovation in tb drug discovery and the emergence of antibiotics resistance therefore new approaches for addressing these challenges are urgently needed mtb is highly adapted to survive into human macrophages which expose the bacterium to many stresses including metal ion intoxification whereby the host cell increases its metal ion levels resulting in inflow of metal ions into mtb the host laboratory has previously demonstrated that the patpase transporter ctpc is part of the metal efflux system involved in zinc detoxification which is important for mtb survival in macrophages intriguingly ctpc and two other patpases are encoded together with small proteins containing a domain of unknown function named duf1490 unpublished data show that the duf1490 protein encoded with ctpc binds zinc and confers zinc intoxification tolerance to mtb additionally duf1490 proteins colocalize with ctpc to the plasma membrane into dynamic microdomains named metal efflux platforms i propose to uncover the function of duf1490 proteins by testing two hypotheses 1 duf1490 proteins are metallochaperones that facilitate the intracellular transport of metal ions to membrane transporters and 2 duf1490 proteins are scaffold proteins involved in patpase stabilization and metal efflux platforms assembly to explore these hypotheses i will combine genetic microbiology and molecular biology strategies with highresolution optical imaging lipidomics and proteomics rigorous execution of the proposed research will generate insights into the role of duf1490 proteins in mtb metal detoxification and pathogenicity as well as into the novel concept of metal efflux platforms thus yielding opportunities for tb drug development that go beyond traditional targets
digital twins enabled indoor air quality management for healthy living

twinair aims to improve urban life by tackling the challenge of indoor air quality iaq improvement by understating its complex interrelationship with external factors this is achieved by introducing a novel set of tools for identifying sources and tracing a variety of pollutants and pathogens for enhancing understanding of their effects and assessing their impact on health for controlling building management systems and services in ways that mitigate part of the impacts and for helping citizens to develop better insights into pollution impacts along with encouraging healthier more sustainable choices twinair embraces bleeding edge innovation in urban sensing chemical and environmental sensors data analytics and visualisation digital maps and realtime video analysis smart buildings digital twins and virtual sensors and behavioural insights citizen participation gamification to deliver a nascent solution it is implemented across six diverse pilot sites in europe es ie uk se de el with demonstrations covering residential dwellings public administration buildings hospitals and schools along with selected types of vehicles buses vans twinairs toolsets will empower students and their parents commuters workers and residents to make more healthaware personal decisions about their everyday mobility options and use of indoor spaces through access to insightful analytics and engaging visualisations of their data as well as by their participation in educational events and activities at the same time it will provide rich evidence to transport planners facility managers and policymakers about factors influencing iaq and effective interventions for mitigating its effects on health and wellbeing by democratising cutting edge innovation in sensors digital twinning and visual analytics twinair will enable better decisionmaking about future mobility policies built environment management and incentivisation of citizensproject twinair is part of the european cluster on indoor air quality and health
cataract simulator diagnostics device development using computational holographic displays

cataracts are the most prevalent blinding disease in the world surgery is the only option for cataracts and it is the most frequently performed surgery worldwide however how the patient will see after surgery and what type of replacement intraocular lens iol is the best option cannot be known in this project computational holography which can control phase size and shape of the light beam entering through the eyepupil will be utilized to develop a holographic vision simulator for cataract patients this will be the first cataract simulator for invivo testing of multifocal iols well develop and perform clinical studies of the novel instrument on patients