Dragon09/odtu_chatbot huggingface dataset:
microbial interactions driven by organic and inorganic metabolic exchange and their role in present and future biogeochemical cycles

many biogeochemical processes such as carbon cycling in marine ecosystems are driven by interactions between microalgae and bacteria global warming changes our oceans impacts algalbacterial interactions and affects the processes these interactions propel if we are to find ways to ameliorate the effects of global warming we need to understand the molecular mechanisms that mediate these key algalbacterial interactions and integrate this knowledge into a biogeochemical context a major challenge in studying these interactions often mediated by secreted metabolites is their complexity in nature therefore we established ecologically relevant model systems with tunable complexities including algalbacterial cocultures genetically tractable synthetic communities and minicosms to study such interactions in context these allow us to monitor and manipulate algae bacteria and their environment we will combine microbiology and earth sciences approaches to generate a blueprint of metabolic circuits that shape the algalbacterialenvironmental interaction landscape specifically we will study1the organic and inorganic secreted metabolome of algae and bacteria 2the physiological response of algae and bacteria to specific organic and inorganic metabolites and the metabolic circuitry connecting algae bacteria and the marine environment3the influence of climate change on algalbacterialenvironmental interactions gaining insight into how key players in the ocean will likely respond to future climate unveiling mechanisms of microbial interactions under various environmental conditions allows us to understand how future climate will impact these interactions and the processes they drive our interdisciplinary research offers a novel framework for studying the role of microbial interactions in biogeochemical cycling it will contribute to improved climate change models and will provide valuable data for ocean stewardship policy makers
next generation multiple architecture battery systems for industry

to date most modern offtheshelf battery designs targeting lightweight application use lithiumion technology this is due to the fact that other existing technologies such as nimh and pbacid are often too heavy leading to energy densities inferior to those of liion technologies new technologies must improve upon energy density whilst also employing green recyclable designs and avoiding the use of critical raw materialsin addition the rapid increase in the number of electrified vehicles especially those employing fastcharging systems has lead to an increasing load on energy generation systems during periods of mass travel for example during the summer vacation season this can lead to severe loading it is therefore important to consider the whole of the electric vehicle system not only at the vehicle level but also at the infrastructure level europe is very strong in terms of its capacity to produce final products such as evs and stationary storage systems but is weaker when considering its capacity to produce and use raw materials advanced materials and equipment for manufacturing cells the overarching of goal of the tempest project is to develop and mature a new generation of safebydesign recyclable highperformance and lightweight batteries for the largest possible swath of transport applications tempest will bring to trl5 advanced modulefree battery systems optimized using ai algorithms and based on both lic and ssc cell chemistries through three different demonstrator batteries types compact largescale and stationary selected as representative batteries for the range of use case applications targeted automotive aircraft maritime rail and stationary tempest has access to direct capacity to scale results
distributed inference for energyefficient monitoring at the network edge

today internet of things iot sensors are being extensively used for monitoring processesphenomena in smart cities the data samples generated by these iot sensors are wirelessly transmitted to servers at the network edge where computeintensive machine learning ml models specifically deep neural networks dnns are used for providing inference however a large percentage of data samples are redundant because they do not significantly improve inference this leads to an excessive and unjustified carbon footprint of these systems as each redundant data sample will contribute to the total system energy tse consumption however there is a lack of research on the design of these systems to reduce the tse by considering the redundancy in the data in dime we explore the tse energy savings in a distributed inference setup by envisaging the deployment of the emerging small dnn models on the iot sensors my objective is to maximize tse energy savings by answering two key questions 1 when should an iot sensor sample the process to reduce redundant samples and 2 where to do the inference on the sample on the iot sensor or at the edge server to reduce tse i will develop a general modelling framework and subsequently design and validate scheduling algorithms and sampling techniques that minimize the tse by reducing the redundant data and maximize accuracy in mlbased monitoring systems to achieve the objective i will leverage my theoretical research experience on modelling and design and analysis of algorithms and the expertise of imdea networks in applied machine learning and systems research dime directly contributes to reducing the carbon footprint of monitoring in smart cities which is in line with the goal of horizon europe to achieve 100 climateneutral smart cities by 2030
center of excellence for weather and climate phase 3

this proposal shapes the next third phase of the esiwace centre of excellence as the ability to run earth system models at 1km resolution efficiently on eurohpc supercomputers has already been established in previous phases for specific model configurations and as developments are now picked up by sciencedriven projects this proposal will focus on the support of the community to reach a higher readiness level regarding exascale supercomputing and knowledge transfer between the different earth system modelling centres and teams across europe the project will focus on three main aims that are essential to prepare existing operational weather and climate prediction systems for the exascale era through i the transfer and establishment of knowledge and technology for efficient and scalable simulations of weather and climate across the earth system modelling community ii closing common technology knowledge gaps and by providing toolboxes for highresolution earth system modelling via joint developments and iii by serving as a sustainable community hub for training communication and dissemination for highperformance computing for weather and climate modelling in europe esiwace3 will bring the various approaches to address these challenges from the different modelling groups together to transfer knowledge across the weather and climate domain to generate synergies between the local efforts to provide targeted support of modelling groups via customised highperformance computing services and to provide training to educate the next generation of researchers
sicilians dreaming louisiana agents of migration and labour recruiters on the palermonew orleans route 18651901

sail analyses early migration from sicily to louisiana between 1865 and 1901 it sheds light on agents of migration who enrolled peasants in sicily and on their transnational connections with labour recruiters based in louisiana who were looking for a labour force after the abolition of slavery at the end of the us civil war in 1865 on the other side of the atlantic the italian government considered emigration as an issue to be managed or opposed the 1901 law restricted the activity of agents of migration who were regarded as people smugglers and used as a scapegoat to justify migration rather than being studied as one of the interrelated factors triggering it this simplistic view permeated the public debate in italy has not been challenged by scholarship on sicilian migration and resonates with current populist and xenophobic narrativessail offers the first comprehensive study of early sicilian migration to louisiana by adopting an interdisciplinary approach combining social economic and cultural history with literature thanks to a thorough investigation and crossreferencing of untapped italian and us archival sources and literary works sail maps the presence of agents of migration in sicily analysing their identity background methods organisation and the transnational connections with labour recruiters in louisiana gauging their effectiveness in disseminating a dreaming image of the usa among sicilian peasants and examining the extent to which their activity impacted the migration flow alongside other factors economic depression political turmoil chain migration remittancessail will fill a scholarly gap develop tools for researching migrations and reflect on sicilys past and its present as one of the main gateways into europe through activities involving academic and nonacademic audiences sail will stimulate a debate and raise awareness around one of europes most pressing concerns safeguarding the right to safe migration
digital twin framework for tailored infant nutrition

the research and innovation program named galatea stands as a pioneering venture targeting infant nutrition through the development of a digital twin of human milk the program brings together interdisciplinary expertise from computational modeling bioinformatics clinical neonatology experimental lab techniques and engineered bioreactors for cell culturing forming a consortium dedicated to advancing our understanding of human milks complexities the overarching objective is to create a sophisticated simulation platform that mirrors the intricate composition of human milk allowing for the formulation of personalized nutrition plans for infants particularly those born prematurely galateas innovative spirit extends beyond computational models encompassing experimental lab work utilizing bioreactors and cuttingedge techniques like metabolomics and proteomics the programs mobility component facilitates crossdisciplinary learning among participating organizations fostering collaborative knowledge exchange anticipated outcomes include enhanced health outcomes for newborns a deeper understanding of human milk for the advancement of artificial milk formulations and the establishment of a robust research community dedicated to neonatal nutrition galatea represents a holistic and innovative approach to the fundamental challenge of infant nutrition setting new standards for personalized strategies and collaborative interdisciplinary efforts
united in narrative diversity cultural exchange and mutual perceptions in eastern and western europe at the threshold of the digital age

europe experiences a relaunch of cultural and national stereotypes triggered by the migration crisis covid19 democratic backslides and war against ukraine four decades after the fall of the war eastern and western europe seem increasingly alienated each having different perceptions on europe the eu and its principles these trends manifest themselves in an alienation between eastern and western europe as well as in the perception of europe in general intermittently they are as we suggest expressions of resilient postcolonial relationships within europewith a focus on the clichd binary eastwest confrontation this project explores the future possibilities of building and managing transnational relationships in the fields of culture and heritage one of the mainstays of customary cultural diplomacy taking six european countries as the basis of our exploration france the netherlands germany poland slovakia and romania we critically examine mutual perceptions in eastern and western europe through the prism of intercultural exchangein the framework of the project scholars practitioners from cultureexchange institutes artists and creative industries players join forces to scrutinise current difficulties from diverging historical developments emotional investments to challenges of the digital media revolution the objective is to develop new strategies to conceptualise and revitalise cultural encounters and exchange between east and west to discuss mutual perceptions and ideas the findings of this collaboration aim at a boosting the culturediplomacy exchange sector by strengthening their role as mediators of transnational european values b lay bare best and worst practices in order to develop recommendations for new approaches and media strategies thus fostering a more inclusive concept of cultural diplomacy to counter populist identitybased discourses and to promote the european narrative across different cultural heritages
the worlds most sensitive absorption microscope

qlibrinano is the worlds most sensitive absorption microscope 1000 times more sensitive than stateoftheart enabling the detection imaging characterization understanding and development of nanoscale matter on a new level by its unique combination of fast and ultrasensitive hyperspectral imaging qlibrinano gives access to a sofar inaccessible area of information relevant for research fields like nanoparticles optical coatings thin films among others making the invisible visible for the first time our innovation rests on the usage of an optical microresonator instead of a conventional objective we have untapped this possibility since qlibri has developed a breakthrough fabrication method of micromirrors based on a semiconductor quantum cascade laser system this proprietary method has allowed qlibri to become the first company in the world to commercialize micromirrors a key component for our firstofitskind resonator microscope qlibris unique blend of expertise combining a profound knowhow in microresonators and deep understanding of microscopy particularly raster scanning techniques has made it possible to make a technology transfer from quantum optics to optical microscopy to develop qlibrinano the great market potential of our disruptive resonator microscope has been confirmed by more than 20 prospective customers this eic transition project has the objective of validating the productmarket fit for the nanotechnology and optical coatings markets improving the technical requirements mostly fast spectroscopy of our system as well as the usability and validating these technological improvements with end users in these sectors trl 6 moreover we aim to improve the manufacturability of qlibrinano and ensure a costefficient scalable and reliable manufacturing upon accomplishment of these objectives qlibri will be in a good position to raise the necessary funds to tackle the trl 79 activities and reach the market by 2027
the role of intestinal antigenpresenting cells in generating t cellmediated antifungal immunity

intestinal fungi are an important component of the microbiome and their homeostasisdysbiosis constantly shapes the immune responses the human commensal fungus candida albicans colonizes the gut of 4080 of individuals however lifethreatening infections caused by this fungus are relatively rare since the unwinding of its pathogenic potential is kept in check by the immune system in line with this immunodeficient patients suffer often from candidiasis which is typically difficult to treat candida albicans induce strong th17 response which is the main protective mechanism against pathogenic fungi candidainduced th17 cells can protect the host not only against other fungal but also against extracellular pathogens besides the positive effects of th17 in defence against pathogens recent studies connect fungielicited th17 response with local and gutdistal pathologies such as asthma multiple sclerosis crohns disease or rheumatoid arthritis despite that the role of th17 is relatively well studied the early events at the initiation of innate and adaptive immune responses against intestinal fungi are much less known various mutations in the adaptive immune system are clearly associated with impaired antifungal immunity the proposed project will fill this knowledge gap by systematic studies of antigenpresenting cells involved in initiating th17 response upon candida colonization we propose to use singlecell rna sequencing techniques to determine candida responsive populations followed by deletion of mhcii on selected apcs populations to prove that the effect is mediated via antigen presentation we will further study the bidirectional interaction between candida and apcs in these mice this study will lead to the understanding of events at the beginning of antifungal response via the identification of cell types responsible for th17 induction as well as the regulation of fungal homeostasis and control of candida virulence
next generation augmented reality technology to improve car safety and driving experience

problem every 40s 1 driver is killed due to smartphone use while driving around the world distracted driving leads to the death of 14 million drivers and 750000 serious injuries per year solution augmented reality ar can greatly improve driving safety today ar head up displays huds are being used in a growing number of cars however most ar hud products do not meet the industrialisation and optical performance requirements of the automotive industry and fail to unlock the safety benefits of artechnology eyelights are on a mission to make driving safer and more enjoyable our patentprotected technology is based on the optimization of light properties through polarised light guides and diffractive nano materials the result is a revolutionary virtual screen which can be projected up to 50m in front of the driver with the smallest form factor in the market this will accelerate the adoption of our technology by the automotive industry and increase driving safety
neuroprotect a novel therapy to prevent chemotherapyinduced peripheral neuropathy

chemotherapy induced peripheral neuropathy cipn is a debilitating neural condition that affects millions of european cancer patients every year it is considered by patients and oncologists to be the most significant longterm impact of cancer treatment and often results in devastating consequences for patients including an inability to work or perform the basic tasks of daily living with chemotherapy usage set to increase by 53 by 2040 cipn remains a clear and urgent unmet patient need cipn is the loss of sensation and movement in the hands and feet induced by chemotherapy treatment and is often associated with chronic neuropathic pain chemotherapy drugs enter the bloodstream and target all fastgrowing rapidly multiplying cells a known characteristic of cancerous cells however many cells of this nature occur naturally in the body including peripheral nerve cells thus a wellknown side effect of chemotherapy is the demyelination of these peripheral nerves ie the destruction of the protective coating of nerve cells localised microvascular compression therapy lmct is a concept developed by the pi focused on temporarily reducing blood flow and unwanted chemotherapy drug delivery at the peripheral nerve fibres during chemotherapy treatment by applying a consistent lowlevel pressure between 40 and 60 mmhg across the skin surface of the hands and feet the local microblood vessels which deliver chemotherapy drugs to the nerve fibres are temporarily occluded causing local chemotherapy delivery to be drastically reduced thus preventing destruction of longchain myelin and maintaining neural function note shortterm and controlled blood flow reductions have been shown to cause no tissue damage in this way the neuroprotect project will deliver a safe and painfree solution to prevent cipn during chemotherapy treatment
partial rebreathing for migraine with aura

migraine with aura ma affects 4 of the global population causing severe attacks that strongly impact patients quality of lifecurrently available treatments are often ineffective contraindicated or prone to side effects causing 74 of migraine patients to be unsatisfied with their current treatment this indicates a large unmet clinical need and a significant commercial potentialthe rehaler medical device is a unique patented nondrug ma treatment that effectively relieves or aborts a high percentage of migraine attacks by modulating co2 and o2 levels in the central nervous system the device has a unique commercial advantage by combining 1 a high treatment effect 2 a low risk profile and 3 simplicity compactness and affordabilityto pave the way for regulatory approval market launch and widescale adoption we will carry out a largescale clinical trial to collect goldstandard safety and performance data while expanding our company team and production capacity
sustainable reliable and efficient floating pv power plants

floating pv if it is to aid the transition to a climateneutral and resilient society and contribute towards the eu policy goals must overcome 3 challenges that are also highlighted in the work programme fpv must prove its sustainability by demonstrating low impact on biodiversity and satisfy endoflife requirements its longevity and reliability by demonstrating system components that satisfy structural and functional requirements for the entire lifecycle and its affordability by reducing the lcoe from fpv power plants these are the challenges that the objectives of sure seek to overcome activities are structured into 3 generalizable topics sustainability reliability and efficiency which gives sure fpv its name and are designed to advance the entire fpv industry we will further work with concrete technology developments for 3 leading european fpv technologies to improve their design sustainability costcompetitiveness and application range the three fpv technology providers are ciel et terre cti who have installed 650 mw globally zimmermann pvsteel group zim who is dominating the european fpv market and sunlit sea sunlit who is providing a innovative fpv solution for offshore deployment cti has recently prototyped a new floater design which will be developed and tested in sure first 50 kw then on 5 mw scale zim aims to expand their technology to higher sea states and will build a 5 mw based on the developments in floater connection and anchoring technology in sure sunlit are about to scale up their fpv technology and see potential for large reductions in cost and co2 footprint through the activities planned in sure they will build a smaller but still commercially relevant pilot of 100 on the norwegian cost ultimately sure will provide both costefficient and sustainable new fpv technologies and generalizable knowledge thereby expanding the potential application areas without environmental sacrifices