Dragon09/odtu_chatbot huggingface dataset:
specific conjugation of antibodies to lipid photoperoxidised cancer tissues for their immunogenic elimination

cancer ranks as a major cause of death with 34 million new incidences in 2020 in europe the current cancer standards of care include surgery chemotherapy radiotherapy and as of late immunotherapy none of which have met their expected therapeutic outcome yet photomedical treatments like photodynamic therapy of cancer pdt and photochemical internalisation pci show great promise as effective anticancer treatments both are however limited by the cancer cells left behind causing cancer recurrence and metastasis after recovering from their sublethal membrane injuriesbut what if we could label these injured cancer cells with antibodies thus activating the immune system to eradicate them scalpel will utilize pdt or pci to destroy the bulk of tumour cells while marking the remaining sublethally damaged cancer cells for destruction by attaching antibodies to their membranes bespoke modified scalpel components will be administered to all cells normal and cancerous following local irradiation only the photomodified components will conjugate with our specially engineered antibodies selectively flagging the cancer cells for destruction moreover the immune system will be trained through this process against the specific cancers offering systemic immunitythe high riskhigh gain nature of scalpel is counterbalanced by an avantgarde multidisciplinary research team covering photomedicinephotobiology immunology synthetic chemistry porphyrin chemistry and protein engineering scalpel is expected to revolutionize oncology by offering a pioneering photoimmunotherapy with curative potential in this project we strive to provide a proofofprinciple of the proposed technology in cell cultures but also in laboratory animals with the long termvision of establishing scalpel as a clinical cancer modality
design of artificial organelles to modulate the astrocyteneuron communication

the brain is supplied by a complex and vast vascular network whose interactions are difficult to grasp in their entirety the neurovascular unit nvu was thus introduced and represents the minimal functional unit linking the brain and its vessels nvu cells interact closely to maintain the integrity of the bloodbrain barrier and supply the brain with nutrients among these astrocytes play the key role of mediator between the endothelial cells supporting the blood flow and the neurons the astrocyteneuron lactate shuttle is an essential communication pathway and its control is crucial for brain homeostasis and thus brain health the research hypothesis of ancom is that the engineering of astrocytes will allow to modulate their communication with neurons in close proximity cultured in a paperbased nvu model engineered astrocytes can thereby be used to influence neurons behaviour and thus contribute to tune the brains activity specifically artificial organelles will be designed to boost the lactate production in the astrocytes these will be made of silica nanoparticles with lactate dehydrogenase enzyme immobilised on their surface and placed in the cytosol of the astrocytes upon a boosted lactate release a beneficial effect on neurons is predicted either in simple cell cocultures but also in more complex systems for that purpose a dynamic in vitro paperbased model of the nvu containing endothelial cells pericytes astrocytes and neurons will be established moreover by employing a new approach developed by the stdler lab it will even be possible to add active locomotion to these artificial organelles with the aim of targeting the astrocytes through the blood circulation ancom aims thus at offering an easily accessible nvu model able to address many questions in neuroscience contributing to the development of brain therapies this interdisciplinary project will allow me to broaden my skills and start my career as an independent researcher
ecofriendly smart multifunctional composite coatings for longlasting corrosion protection of magnesium and its alloys

the world is moving towards sustainable economic growth and green technologies therefore the high specific strength easy recyclability and lightweight of magnesium mg based materials make them potential options to minimize weight save energy and reduce environmental issues however their poor corrosion resistance in aqueous and atmospheric conditions limits their widespread usage in many industrial applications enormous effort has been made to protect mg and its alloys against degradation and improve their service time despite that the questions related to their durability longevity biocompatibility cost and environmental impacts must be resolved this scientific work aims to develop durable multifunctional multilayer composite mmc coatings to provide longterm corrosion protection to mgbased materials durability and longterm protection will be achieved by using ecofriendly materials and considering interfacial adhesion strength between substratecomposite within the multilayers and their surrounding environments mmc coatings will be prepared to protect mgbased materials against corrosion and give a visual response when the coating is damaged to achieve this scientific goal mmc coating will consist of a selfassembled organic layer a polymeric composite containing corrosion inhibitor and sensing agents loaded metalorganic frameworks mof using a stimuliresponsive polymeric gatekeeper in a single layer and a top selfcleaning hydrophobic polymeric layer they will provide adequate longterm corrosion protection of mgbased structures by the synergistic effect of selfcleaning passive barrier layers and ondemand release of active corrosion inhibitors from loaded mof corrosionsensing agents encapsulated mof will monitor the onset of corrosion upon physical damage to the coatings for large area systems mmc coatings will ensure minimum cost and environmental impacts consistent with desired properties and help to substitute pfas
integrated optomechanical nanoresonators for realtime singlemolecule detection thorugh photothermal spectroscopy

optical absorption microscopy based on the photothermal heating effect has recently succeeded in detecting single molecules with a temperaturesensitive nanomechanical resonator molecules are sampled onto the nanomechanical resonator and probed with a freespace laser upon scanning optical absorption and photothermal heating of the sample results in a detectable detuning in the mechanical resonance frequency this technique has overcome the main limitations of alternative optical probing methods a remaining challenge of nanomechanical photothermal microscopy is the alignment of the freespace optics with the intersecting molecular sample beam necessary to perform timeresolved singlemolecule spectroscopy furthermore offplane optics limits its possibility to be miniaturized integrating nirmir waveguides in nanomechanical resonators will create an innovative optomechanical device that solves the alignment problem increases the field of view decreases optical complexity and enables photothermal spectroscopy miniaturization avoiding absorption spectroscopy limitations iefabryperot resonances outcoupling and propagation losses we propose to give the first steps towards a complete integrated photothermal spectroscopic device for singlemolecule analysis dispensing with freespace optics in the envisioned design the probing light travels inside the nanomechanical resonator orthogonal to the sample beam resulting in an evanescent interaction with the sample molecules on the surface this design will enable the detection of singlemolecule deposition events from heterogenous samples in particular airborne particles and proteins in solution will be the target analyte due to its environmental and health relevance furthermore the selectivity provided by the spectroscopic measurement allows for identifying and monitoring neoplastic while the device holds potential use for early diagnostics
researchers and citizens facing together the european challenges

the european researchers night in madrid will bring together researchers to the general public and will increase awareness of the importance and benefits of research and innovation creating an understanding of the impact of researchers work on citizens daily life and raising young peoples interest in science and research careersthe project will achieve these objectives by means of festive activities to be carried out in the region of madrid in the morning and evening of the last friday and saturday of september 20222023 pre events and post events will be also organized the madrid night project also includes researchers at schools activities throughout the year in these activities researchers will be visiting schools allowing teachers and pupils to engage with them on important topics faced by our societies such as those included in the missions in horizon europe cancer adaptation to climate change healthy oceans seas coastal and inland waters climateneutral and smart cities and soil health and food students and teachers will also visit the researchers workplaces the madridnight activities will be addressed to public at large scienceaddicts and sciencereluctant children families teachers elderly people regardless their scientific background with a special focus on families pupils and students with the main purpose of encouraging stem subjects and science careers university students and also vocational education and training students different activities will be offered focused on the missions in horizon europe the project will involve researchers benefited by eu funds especially the msca the activities will point out the transnational and diversity aspects of research showing the attractiveness of their jobs that can be done everywhere in europe universities research centres museums hospitals ngos foundations and industry spin offs sme or large companies in the region of madrid will be at the core of the project
bypassing open heart surgery with excimer laser assisted non occlusive anastomosis elana

we will revolutionise the medical field by replacing expensive invasive and highrisk openheart surgery with keyhole minimally invasive surgery mis to treat coronary artery disease cad our elana technology enables reproducible coronary artery bypass grafting cabg surgery without the need of heart arrest and suturing thus avoiding the need to open the patients chest this is realised with an innovative clip which circumvents the need of suturing of blood vessels altogether by realising closedchest cabg elana reduces not only the risks associated with traditional cabg such as bleeding stroke and wound infection but also significantly shortens recovery times as a result elana will reduce direct healthcare costs of cabg procedures by over 50 to critically derisk our technological development and accelerate market entry to 2025 amt medical seeks a total of 75m funding 25m grant 5m equity to finalise clinical validation and gain market approval
upscaling innovative green urban logistics solutions through multiactor collaboration and piinspired last mile deliveries

urbane brings together a multidisciplinary group of 41 partners from 12 different eu member states including 12 cities industry leaders in logistics services novel solution providers for shared connected and automated operations and research experts to codevelop novel last mile delivery solutions combining green automated vehicles and shared space utilisation models the project will support the transition path towards effective resilient safe and sustainable last mile transport through four lighthouse living labs helsinki bologna valladolid and thessaloniki that will demonstrate trl78 efficient replicable and socially acceptable innovative last mile delivery solutions wave 1 lls building on existing trl5 assets handson lesson learning at european level will be primarily facilitated by an innovation transferability platform comprising digital twinning tools open models smart contracts governed by blockchain technology and a datadriven impact assessment radar that will enable the adaptation and replication of wave 1 solutions in two twinning lls in barcelona and karlsruhe wave 2 lls demonstrating their own solutions within the course of the project urbanes commitment to upscaling is further strengthened by the engagement of six early adopters follower cities in innovations adoption feasibility studies thus stimulating the formulation of new ll communities across europe the approach employs social simulation tools to experiment with possible strategies urbane will provide evidence of the real introduction of the physical internet in urban deliveries for the first time
moral emotions in politics how they unite how they divide

liberal democracy is struggling with the challenge of citizens indifference and detachment from politics while antisystem politicians are overemotionalising policy issues which furthers polarisation in society the normative stance of mores is that both under and overemotionalisation of politics should be avoided the former leads to the affective disconnect of citizens from politics while the latter spurs tribal politics and hampers deliberation both extremes threaten democracymores argues that moral emotions and moralised political identities a conceptual innovation of the project have a practical value in dealing with the challenges of affective politics moral emotions are linked to the interests or welfare of society or at least of persons other than the subject itself they can unite people towards common causes or split them along moralised political identities mores applies a horizontally wide research logic to build a normativeanalytical framework to inform democratic decisionmaking on how moral emotions should interact with values policies and political practices mores will create stateoftheart methods and generate new empirical data on 1 the type of moral emotions triggered by political actions and phenomena such as campaigns leadership styles and illiberal politics 2 the role of moral emotions in forging moralised political identities 3 the effect of moral emotions on political behaviour such as policy support and civic activism and 4 the contextual social phenomena including digital universes of the moral emotionspolitics nexusthrough research engagement with key stakeholders mores will create several innovative tools including a method for policymakers to measure the emotional valence of policies games to strengthen citizens politicalemotional resilience both in reallife and metaverses and policy ideas to embed citizens moralemotional needs in policymaking towards bolstering trust in democratic governance
privacy preserving identity management for digital wallet and secure data sharing and processing for cyber threat intelligence data

prividema represents an industrydriven initiative to advance privacypreserving technologies in the application areas of cyber threat intelligence data protection and identity management this multifaceted project operates across various research and innovation maturity levels with the overarching goal of introducing more robust userfriendly and scalable privacy and security technologies for the european ecosystem key components of prividema include 1 development of opensource tools hosting networking events and initiation of capacitybuilding efforts to democratize technology access and empower cybersecurity professionals 2 advancement of homomorphic encryption capabilities implementation of hardware acceleration methods and improvement of fully homomorphic encryption fhe usability 3 creation and demonstration of a prototype european identity wallet featuring issuer and relaying party functionalities 4 development and demonstration of a prototype european privacypreserving cyber threat data processing system with realworld testing and validation of innovative technologies aligned with the objectives of horizon europe prividema actively contributes to increased cybersecurity data and network protection and the establishment of robust digital infrastructures the project distinguishes itself through its commitment to supporting smes as well as promoting opensource development crossdisciplinary collaboration and privacybydesign principles the solutionoriented approach positions prividema as a pivotal force in advancing cyberresilient digitalization and the data economy in europe prividemas connection to various european strategic initiatives underscores its relevance with a clear emphasis on realworld applications innovation beyond the stateoftheart and a strategic trajectory toward marketready solutions
hybrid nanostructured systems for sustainable energy storage

humanity will increasingly need safe clean and always available energy thus having good energy storage systems will be more and more important in the future efficient and sustainable rechargeable batteries are required to power portable electronic devices new hybrid electric vehicles and to store electricity from renewable sourcesthe mission of hynanostore is the development of new environmentfriendly systems based on that organic molecules which are used in the chemistry of life for the storage of chemical energy and its transformation in electrical energy hynanostore rethinks the concept of batterys electrode based on lithium insertion and propose a novel architecture in which the redox properties of biomolecules such as enzymatic cofactors can take up and release ions reversibly in order to overcome the problems safety sustainability and longterm ciclability associated with the use of conventional li ion batteriesto achieve this a nanostructured conductive scaffold with tailored characteristics will provide a framework to immobilize redox active molecules extended surface area to maximize their loading a pathway for the charge transport and a diffuse interface for the interaction with the electrolyte the new bioinspired engineered system developed after the successful completion of hynanostore will offer benefits in terms of power and cyclability an energy density of 500 w h kg1 and the retention of at least 90 capacity after cycling 800 times are expected with the implementation of these systemsthe output of the project hynanostore will be the introduction of a new concept for lithium ion batteries towards cheap green and versatile energy storage devices
redesigning aortic endograft enabling insitu personalized aneurysm healing

forty years ago the endograft eg enabled the endovascular treatment of aortic aneurysm aoa and revolutionized vascular surgery still since then its technological concept has remained substantially unchanged eg is a passive device aimed at treating the aoa in its late stage not to cure the disease even when discovered early this proposal introduces a bioengineered process to redesign egs as 3d bioprinted bioresorbable devices loaded with active drug components and validated invitro to enable the paradigm shift from endstage treatment to early personalized healingto this aim epeius must tackle three open challenges 1 available animal models often fail to predict human safety and efficacy for candidate therapies 2 potentially effective drugs are challenging to deliver in therapeutic concentrations at the target 3 consequently there is a limited capacity of aoa healing even for compounds that were preclinically promising we hypothesize that these challenges can be solved simultaneously by designing and fabricating a human invitro model of aoa where we can track aoa progression in the presenceabsence of bioengineered eg delivering therapeutic drugs grounded on a multidisciplinary approach epeius will act as the trojan horse to enable the local healing of arterial wallsto verify our hypothesis we will integrate 3d bioprinting and computational biomechanics to aim 1 create an invitro model of aoa recapitulating dysfunction of endothelial and vascular smooth muscle cells degeneration of extracellular matrix overall driven by inflammatory stateaims 2 create a customizable eg to carry drug insituaims 3 assess invitro the regenerative power of the mesenchymal stem cells secretome to heal aoa epeius will directly tackle a prominent medical issue but we are convinced that this innovation in computeraided engineering additive manufacturing and invitro pharmacology will create the next generation endovascular device
replicable interoperable crosssector solutions and energy services for demand side flexibility markets

reeflex aims to generate niches of opportunities for new crosssector energy services provided by smes and startups in demand side flexibility markets and to increase participation of energy consumers in demand side flexibility markets the project develops a central interoperability platform and a catalogue of services with the capability of maximising distributed energy resources flexibility while respecting the different end user profiles and needs along with the physical limitations of existing infrastructures additionally the generation of a common operation market model together with aidriven intelligence services and automation systems enabled through the utilization of distributed ledger technologies for enhancing transparency and trust will reduce market entry barriers and costs and achieve a higher participation from energy consumers they will benefit from new revenues obtained through data and flexibility transactions while enjoying innovative personalized data intelligencedriven services for smart humancentric control of their assets in the frame of demand response or selfconsumptionreeflex solutions they will be demonstrated and crosstested in 4 main demonstrators spain greece switzerland bulgaria with different characteristics allowing evaluation of their impact under alternative scenarios and integrating a variety of sectors such as residential buildings mobility commercial establishments industrial sites or data centres among others in addition the services catalogue will be further replicated in three additional replicators across europe to achieve wider coverage turkey portugal denmark and adaptation endingup in a total of 7 countries for the whole project execution these crosstested demonstrators and additional replication campaigns are structured around 8 different use cases that cover a comprehensive set of consumer groups to participate in up to 12 demand side flexibility services