Dragon09/odtu_chatbot huggingface dataset:
our science 202223

the impact of researchers work on society and citizens has never been more apparent than now global challenges such as climate change and unprecedented health pandemic calls for science to react and the role of researchers is crucial at the same time there is an impending risk of loosing citizens trust in science due to increased amount of misinformation about science and research therefore it is important to promote the key role that researchers have for development and growth of our societies in a national and international context and for keeping the public informed about critical challenges and scientific discoveries that have an impact on our daily lives in iceland science has a crucial role to play in a society that relies on nature and responsible use of natural resources from renewable energy and sustainable blue growth to societal and cultural implications of living at the edge of the arctic in order to ensure and facilitate interaction with the public and society at large the project our science aims to organise european researchers night in iceland 2022 and 2023 inviting researchers to engage with the public to communicate their work their passion and findings to increase awareness of research and innovation activities the objective is to enhance a positive public perception of researchers by facilitiating open and active dialogue between researchers and citizens of all ages especially focusing on children and young people that could consider a career in research in addition to higlighting the importance of researchers work the initiative provides a rare opportunity for researchers to communicate directly with the public at all ages meeting children in school visits and even involving citizens in the road to scientific discoveries thus contributing to the transparency of their work and enhancing the attractiveness of scientific careers which is instrumental in encouraging young people to embark on a career in science
neural encoding of novel and familiar protomusical patterns in humans and monkeys

the capacity to perceive and produce music musicality has ancient but mysterious roots while musicality is nearly ubiquitous across human ages and cultures it seems to be scarcely developed in nonhuman primates such as rhesus monkeys this is surprising given that rhesus monkeys are not only one of our closest relatives but also a fundamental model for human auditory function and communication phylomusic proposes an innovative approach to the study of musicality in nonhuman primates macaca mulatta rather than focusing on isolated musical features such as toneorder or rhythm it combines them to form protomusical patterns phylomusic takes i the detection of protomusical patterns and ii their memorization as two pillars of musicality with this phylomusic proposes a series of noninvasive electroencephalography eeg studies aimed to test whether and how protomusical patterns are detected and memorized in both short and longterm in rhesus monkeys and as a comparison in humans combining notions from comparative research music auditory computational neuroscience and stateoftheart brain signal analysis phylomusic is a multidisciplinary project that has the potential to impact upon three distinct research areas first it will shed light upon the mysterious evolutionary origins of musicality unveiling whether music processing is phylogenetically conserved and how mnemonic systems may have evolved to support musicality in humans second it will introduce novel analytical approaches to the fastrising field of nonhuman primate neuroimaging last but not least it might provide an empirical ground for realistically testing at the neuronal and circuitry level the widespread use of music in clinical settings having noteworthy implications for human health
onantenna multianalyte biochemical sensing asense

labonchip loc devices are useful for manipulating analyzing and interacting with small samples in a wide range of applications wireless loc devices have been developed for remote and distributed analysis purposes where wired measurements are not feasible or costeffective the devices consist of a miniaturized array of biochemical sensors connected to a lowpower radio transceiver the current trend in wireless loc devices is to miniaturize the sizes lower the power consumption and increase the processor capacity while driving down costs which are rapidly approaching their practical and theoretical limits these raise the need for a new design to support the future sustainability of these devices to facilitate the current and upcoming massive deployments for use in various applications triggered by this the project explores the revolutionary secondary use of the wireless antenna for multianalyte active sensing purposes by deploying casetailored sensing nanomaterials on the antenna surfaces current spots with each targeting a specific analyte using a molecular imprinting polymer mip layer grown above a highly conductive 2d transduction nanomaterial layer the idea is to move the complexity from the wireless loc to the computation of the gateway station where signal processing and machine learning techniques are employed to remotely sense the targeted analytes this is done by detecting changes on the radiation characteristics of the antenna caused by the applied sensing materials the idea of using the antenna as a multianalyte active sensor is an absolute novelty if successful the approach will have a huge contribution in reducing the hardware complexity of standard wireless loc devices by at least 50 no need to sensor integrated circuits microcontrollers and their associated power consumption resulting in more than doubling their battery lifetime due to less power consumption making largescale mass deployment economically feasible
healthy public engagement in groningen chronically healthy

healthy public engagement in groningen chronically healthy promotes science and scientists on public health in an interactive accessible and innovative way our main goal is to inform the residents of the northern netherlands on the impact of sleep and toxics on public health and about researchers and their workeducation programwe teach children about the effect of sleep and toxics on our health and ways to avoid being harmed by toxic elements in water food soil or air or by lack of sleep by bringing researchers into the classroom and having children actively perform science we increase their understanding of science and encourage the pupils to embark on research careers besides that we train teachers to bring science into their classrooms which promotes a durable effecteuropean researchers nightsduring the nights a bridge is built between researchers and the audience in an entertaining and educational quiz show the show invites multidisciplinary researchers to share their research findings on sleep 2022 and toxics 2023 and invites members of the public to share their experience both years two different shows are created one for children and one for adultsboth years an interactive exhibit will be developed engaging with this exhibit the visitor gains insight in the importance of sleep and toxics and the role of science in everyday life moreover the visitor experiences how she can directly or indirectly take more control of her own health and the people around her alongside the exhibit researchers will hold informal accessible and interactive talks on their own subject of researchposteventsafter the night the exhibit will tour to schools and community centres in the region to reach out to the public that does not usually interact with science in excursions to the visualisation experts of the university of groningen and the dutch authority on food and consumer product school classes get to see science in action
quantum interacting topological optics

atomlight interfaces are vital for a range of potential applications in the coming second quantum revolution from secure communication to ultraprecise sensors to quantum computers a new exciting possibility is to arrange atoms in dense regular arrays where wave interference leads to strong collective emission this property has been shown to polynomially or even exponentially improve the efficiency of singlephotonlevel applications a frontier still awaiting a breakthrough is in the manybody regime in particular to expand the realm of atom arrays interacting with light toward realizing and studying exotic strongly correlated behaviorin quinto quantum interacting topological optics we will propose routes by which such systems can realize manybody states featuring topological order to tos have attracted significant interest due to wideranging implications ranging from possible faulttolerant quantum computing to surprising fundamental properties such as the emergence of anyonic quasiparticles being neither bosons nor fermions and emergent lattice gauge theories we will use the known physics of tos within condensed matter physics as a window to developing the concept of manybody quantum optics and show that in turn the arrays provide new ways of creating understanding and measuring toswe will employ innovative condensedmatterinspired theoretical and numerical techniques breaking stateoftheart limitations e g on system size to study two routes towards quantumoptical tos arrays in optical cavities and topological bands in freespace arrays we aim to i demonstrate that longrange interactions induced by emission and reabsorption of photons provides a new paradigm for inducing tos ii elucidate the influence of such interactions on fundamental to physics and iii show that the output light carries information sufficient to detect a to including signatures of anyons
elucidating the role of macroh2a12 histone variant as a metabolic sensor in the epigenetic regulation of leukaemia cell fate

the initiation and maintenance of leukaemia are often regulated through the interaction of epigenetic mechanisms and metabolism but how these affect each other is not always fully understood one of the epigenetic mechanisms that alter cell fate is the replacement of replicationcoupled histones with noncanonical variants macroh2a mh2a variants mh2a11 mh2a12 and mh2a2 have a large metabolitebinding macrodomain and differ from each other solely in the structure of their ligandbinding pocket of those three only mh2a11 has known ligands while the binding partner and corresponding biological functions of mh2a12 are still unknownthe preliminary data suggest phospholipid molecules as unique ligands of mh2a12 at the same time they show that the macroh2a1 is required for the maintenance of the stemness of leukaemia stem cells and leukaemia itself during the chromet project by using cuttingedge techniques in cell and molecular biology computational biology and biochemistry i aim i to confirm the identity of putative ligands of mh2a12 and to biophysically characterize the binding interaction and ii to test the contribution of the newly identified metabolitebinding capacity of mh2a12 on the leukemia cell differentiation and tumorigenicity the findings of the project will allow me to describe the mh2a12 as an entirely novel metabolic sensor on chromatin which through the binding of phospholipid ligands regulates cell metabolism and impacts leukaemia cell fatethe complementary knowledge and expertise of the hosting group in epigenetics and metabolism the hosting institute and longstanding collaborators in leukemia research and my own in biochemical analyses of proteinligand interactions will ensure the successful realization of the proposed project and contribute to the development of my career as an independent researcher committed to exploring an interplay between epigenetics metabolism and cancer
packaging of novel ultradynamic photonic switches and transceivers for integration into 5g radio access network and datacenter subsystems

punch offers a solution for timedeterministic and timesensitive networks by developing a new optical switching paradigm which i breaks the tradeoff between flexibility ultradynamic reconfigurability and determinism guaranteed latency and jitter by offering an alltoall reconfigurable interconnect ii reduces congestion by activating bandwidth steering so that additional capacity can be allocated between hot nodes in the network iii provides unparalleled dynamics and bandwidth efficiency by further enabling multiplexing in the time domain with fast reconfigurable capability a 228lambda wavelength selective switching element will be scaled to a fully nonblocking 8x8x8lambda and 16x16x8lambda reconfigurable optical switch fabric the development of a microtransferprinting process for semiconductor optical amplifiers enables lossless optical switching on a silicon photonics platform custom configuration electronic ics to actuate control and powermonitor a scaled switch fabric will be densely integrated with the photonic ics into a heterogeneous fanout waferlevel package processed on a 200mm reconstructed wafer platform in addition the optical interfacing to the photonic ics will be accomplished using an optical redistribution layer providing an optical fanout on highdensity organic substrates and allowing for a scalable optical fiber packaging solution the novel integration and packaging processes will be applied for manufacturing 16 tbits optical transceivers providing the interface between optical switches and electronic resources compute memory and storage the optical switch and transceiver prototypes will be demonstrated in a 5g ran transport network for tsn fronthaul applications and for memory disaggregation in data centers
demonstrating real and affordable sustainable building solutions with toplevel whole lifecycle performance and improved circularity

drastic will pave the way for significant whole lifecycle ghg emission reduction in new construction and deepenergy retrofit by demonstrating affordable innovative circular solutions in 5 different geographical zones covering different building layers accounting for 90 of ghg emissions raw materials accounting for 72 ghg emissions buildings typologies accounting for 80 of all buildings circular strategies reaching up to 60 of ghg emission reduction and local drivers the demonstrators untap on eu scale the potential of 491 mtco2eq savings annually and a financial divergence potential of 334 b annually within defined market conditions and based on circular business models to reach this ambitious goal 23 partners from 8 european countries collaborate covering the entire value chain and supported by a cocreation strategy with relevant stakeholders to assess and validate the solutions an innovative multicyclic performance assessment framework will be developed and applied integrating multicycle lca multicycle lcc circularity and sufficiency for construction and building related products and components novel datadriven tools covering quality evaluation thermal efficiency automatic identification of assets and their reusability condition multicycle traceability and social acceptance will be enhanced demonstrated and combined in a toolbox integrated in a common digital platform going beyond a digital building logbook high impact dissemination and communication of resultskey deliverables will be led by the world green building council and maximized by its global network the drastic project will contribute to the objectives of the eu by demonstrating the feasibility of promising and affordable new technologies processes and products combined with new business models for faster market uptake leading towards more sustainable buildings with reduced lifecycle carbon high lifecycle performance and reduced lifecycle costs
thermochemical heat recovery and upgrade for industrial processes techupgrade

this project aims to develop and validate in the relevant environment to reach trl 5 a novel thermochemically operating technology that can very efficiently safely costeffectively and sustainably provide waste heat recovery of industrial processes and upgrade them to much higher temperature levels the target temperature will be 150250 deg c here the technology is a novel yet outstanding generation of heat transformers hydration heat transformer outperforming any other competing technologies including various designs of hightemperature vapor compression heat pumps due to several reasons that is techupgrades solution i may simply be integrated with any renewable technologies including solar thermal systems ii consumes almost no electricity and presents significantly high energy and exergy efficiencies iii can be much more costeffective than competing technologies due to expected long useful lifespan the simplicity of the design and operation mechanism and the way it integrates lowvalue heat sources iv may be employed for a variety of integration possibilities lowtemperature heat sources and various heat sink temperature levels and also v with simple adjustment can offer the storage of the recovered waste or renewable heat if there is a mismatch between the heat source availability and the process heating demand the project consortium consists of 14 partners from the four corners of the eu including 5 universities 3 research centers 4 smes 1 large company and 1 partner with several industrial endusers making sure that all the required expertise for a successful accomplishment of the project and future exploitation exist and also the partners supplement each other in the most optimal manner the technology will be demonstrated in different specific designs and integrations in two relevant environments in sweden and germany in 35 kw and 10 kw hightemperature heat delivery capacities
decentralized cryptographic systems

much of our digital infrastructure still relies on centralized systems which are prone to failure and more importantly present appealing targets for criminals and other illintentioned parties a successful attack on a centralized system can have huge repercussions in terms of loss of confidentiality integrity and availability of data and services alas once private data leaks it is impossible to put it back into the confidential domain the fragility of centralized systems is one of the reasons that the interest in decentralized cryptographic systems such as secure multiparty computation blockchains and threshold cryptography has surged in recent years decentralized systems are more resilient against external and internal threats even if some fractions of the parties are corrupt and misbehave it is still possible to guarantee crucial security properties such as data privacy and correctness of outcomes however as these systems get deployed and used by citizens and institutions it becomes evident that many of the assumptions made in the scientific literature do not match the reality in which such systems are used as security proofs might no longer hold this opens the door for potentially catastrophic security consequences with this project i intend to take a step back and design cryptographic systems with solid theoretical foundations with focus on ensuring that the abstract models in which cryptographic systems are designed and proven secure are a close match to the everchanging reality in which they get deployed addressing eg the peculiar nature of decentralized systems and the challenges presented by advances in quantum computing a successful outcome of the project will lead to novel more efficient and more secure cryptographic protocols for complex tasks all the results of the projects will be made publicly available to help companies and society secure the critical infrastructures underlying their digital interactions
solid frustratedlewispair singleatom catalysts for efficient photocatalytic amidation processes

as the shadow of climate change deepens and calls for sustainability grow louder the fine chemical industry faces a dilemma on the one side traditional processes optimised over decades increasingly fall foul of environmental regulations this is particularly true for amidations one of the most commonly performed industrial processes current powerhungry protocols largely rely on wasteful stoichiometric agents on the other side promising catalytic innovations like singleatom catalysts sacs and frustrated lewis pairs flps fail to make the leap to industry due to fundamental limitations and lack of scalability studiessolcat will address these challenges by designing single atomflps saflps a novel family of hybrid catalysts herein flps will be embedded into the very surface of a solid support ensuring stability and accessibility adjacent to them photoactive sacs will be anchored fostering a synergistic interaction between the two catalytic sites guided by computational models and cuttingedge characterisation the structurefunction relationship of the new catalysts will be elucidated and continually refined armed with these insights the exceptional activity of the saflps will be unleashed towards photocatalytic amidations the process will then be adapted to operate under flow bridging the divide between academia and industry to achieve these objectives this action will consolidate an interdisciplinary team of experts both in industry and academia as a result a new class of bifunctional catalysts will be established and optimised towards one of the most ubiquitous and polluting industrial processes importantly it will impart a diverse set of skills in research leadership and project management alongside an extensive network of collaborators to an experienced researcher thus propelling him towards scientific independence
the role of plant microbiota in the evolution of fungal pathogens and their repertoires of secreted proteins

fungalfungal plant pathogens have a devastating impact on crop production decades of research have addressed the molecular interaction of pathogens with plant immune responses and have established effector proteins as key molecules secreted by pathogens to interact with plant receptors studies of fungal pathogens have revealed a large diversity of predicted effector proteins expressed during plant colonization yet the functional relevance of most remains unknown i hypothesize that fungal pathogens secrete a diverse repertoire of effectors to manipulate hostassociated microbiota and facilitate host invasion as distinct plant species assemble distinct microbial communities i hypothesize that effector evolution and host specialization of pathogens in part is driven by the hostassociated microbiota fungalsecrets will combine bioinformatics evolutionary analyses molecular microbiology approaches and plant infection assays our research will focus on 2000 effectors and effectorlike proteins produced by four pathogens infecting wild relatives of crop plants we will predict the protein structures of effectors to identify new homology relationships and to make inference of protein interactions and coevolution next we will identify antimicrobial properties and determine the effect of each effector protein on the growth of 400 bacteria isolated from the host plants of the pathogens to overcome challenges of heterologous protein expression we will use different expression systems to obtain mechanistic insights into microbial interactions we will conduct detailed analyses of a selected set of candidate effectors with pleiotropic functions in virulence and microbiota manipulation fungalsecrets is based on innovative hypotheses and will cover a fundamental knowledge gap related to the ecology of fungal pathogens the research will have implications for applied crop research and will stimulate new research of fungi associated with human and animal microbiota