Dragon09/odtu_chatbot huggingface dataset:
innovative designs extrapolation simulation methods and evidencetools for rare diseases addressing regulatory needs

the evaluation of new medicines for rare diseases rd including rare paediatric rds is challenging for several reasons among which are the small patient sample sizes heterogeneity of patients and diseases and heterogeneity in disease knowledge due to these difficulties access to effective treatments and the number of treatment options are often limited in rds invents aims to provide clinical trial trialists researchers and regulators with a global framework encompassing methods workflows and evidence assessment tools to be implemented in orphan and paediatric drug development our ambition is to significantly improve the evaluation of evidence and regulatory decisionmaking through the development and validation of refined longitudinal modelbased diseases trajectories and treatment effect improved extrapolation models in silico trials eg virtual patient cohorts optimised modelbased clinical trial designs and evidence synthesis methods these will be evaluated through simulation studies and tested on extensive data from a range of use cases provided by our industrial partners roche and novartis and real world data rwd from rd registry the invents framework will improve consistency and efficiency of the drug evaluation process for rd by augmenting clinical evidence without compromising its scientific integrity and providing regulators assessment credibility criteria at the end of this 5 years project the european industry will be able to exploit novel and improved clinical trial designs in silico trials and rwd analysis approaches supporting drug development in rd the european medicine agency and european national regulators including health technology assessment bodies will be supplied with a general framework allowing better informed decisionmaking most importantly rd patients will benefit from an increased and faster access to efficacious and safe treatments
consolidating the expertise of necmettin erbakan university towards the development of biofibers for wound healing and tissue regeneration

biomaterials have gained much interest as a very important category of materials because of their wide application in medicine and benefit to patient such as increased longevity and improved quality of life there is clear evidence of a stable increase of the biomaterials market for the next fifteen years european biomaterials market represents a market of 7 billion and the global biomaterials market is five times the european market biomaterials sector has not yet been in a good position among the highvalue chains in turkey turkey imports biomedical devices instruments and materials especially advanced therapy and medicinal products atmps about 85 in turkey few rd activities and limited coordination of academyindustry are the main barriers to develop competitive biomaterial products and high value research in biomaterials field in turkey necmettin erbakan university neu is a young university in konyaturkey with wellequipped faculty of medicine faculty of dentistry institute of science and the dedicated research center science and technology research and application centre brings together the scientists researching on medicine material energy biomaterial sciences and focusing on creative answers to todays scientific challenges neu has weakness on developing functional biofibers for medicinal applications specifically to be applied in wound healing and tissue regeneration the proposal regeneu aims to meet the requirements of the horizonwidera2021access0301 twinning call the main focus of this project is to increase the scientific capabilities and excellence of neu in the field of biofiber research and development for translational application this target is supported by european partners fraunhofer germany ukw germany tcd ireland and rcsi ireland neu needs to transfer knowledge about its weak side on the development and production of innovative and gmp conform functionalized biofibers for wound healing
role and modulation of zincfinger antiviral protein and antiviral regnase1like endonucleases

the human zinc finger antiviral protein zap is capable of inhibiting several major human pathogens including influenza a virus and sarscov2 zap specifically targets cpg dinucleotides in rnas and might be one of the reasons why cpgs are strongly suppressed in the human genome successful viruses such as hiv1 and sarscov2 mimic human cpg suppression to partially evade the inhibitory effects of zap however especially under conditions of infection or inflammation when zap is expressed at high levels it inhibits both cpg containing viral as well as cellular rnas importantly zap itself does not possess rnase activity and is dependent on cofactors such as khnyn to destroy viral rnas khnyn is tightly regulated and inactivated by malt1 a cellular protease representing an important target in cancer immunotherapies although some progress has been made the identity of zap cofactors as well as their mechanisms of action and therapeutic potential are poorly understood this proposal aims to combine the expertise of the applicant mechanistic studies of zap and rnatargeting factors and the host respiratory viruses and antiviral drug development to define how zapdependent and independent antiviral endonucleases restrict major respiratory viral pathogens in addition it will be examined whether malt1 inhibitors that are currently in clinical trials against cancers allow to enhance and maintain the antiviral activity of zap and its cofactors thus offering prospects for the treatment of respiratory infections finally potential sideeffects on cellular rnas and their impact on immune signalling cell activation and infection outcome will be determined the project will combine innovative crisprcas9 genome editing in vitro virus infection platforms novel functional assays and stateoftheart deep sequencing technologies to significantly advance the knowledge on antiviral rnases and to clarify whether they can be strengthened for antiviral therapy
rapid elimination of invasive insect agricultural pest outbreaks by tackling them with sterile insect technique programs

react aims to develop longterm environmentally friendly response strategies and novel sustainable tools to protect fruit and vegetable production and export capacities from two invasive insect pests of eu priority bactrocera dorsalis bd and b zonata bz the project proposes a holistic response plan to provide enhanced capacity to prevent identify monitor and control these pests to assess invasion risks react will characterize the main facilitators and critical drivers of early invasive processes sources and dynamics of adventive populations and suitable hotspots for species establishment coupled with the analysis of the potential ecological and socioeconomic impacts of invasions to fight invasions at the first onset react will develop a novel fielddeployable rapid and costeffective mobile solution for interception multiple novel reaction strategy components and tools tailored to the characterized bioecological features of bd and bz will be developed and integrated to tackle outbreak events by economically sound sit programs these include a new bioinformatic pipeline to develop neoclassical genetic sexing strains for the target species novel genetic and metabolic markers to assess the quality of massreared flies and diet supplements for enhanced massrearing to prove the feasibility of an eradication sit approach for the first time in europe releases with ceratitis capitata will be conducted in areas with low pest prevalence mimicking invasion scenarios the program and its socioeconomic impact will be evaluated with stakeholders and multiple actors and a quick intervention guide for diverse invasion risk scenarios will be developed this will translate into rapid response pest eradication capabilities that are pesticide free adequate to a wide variety of eu fruticulture and trade under changing climatic legal and regulatory conditions and able to safeguard ecosystems and biodiversity while improving food safety
the grasshopper network jumping forward from preclinical development of pediatric cancer drugs to clinical implementation

every year 16000 children in europe are diagnosed with cancer and 2000 children approximately 70 school classes die from this illness new therapeutic solutions are advancing rapidly however the optimization and implementation into clinical trials accessible for these children is lacking behind new therapeutic interventions often dont make it through the valley of death between preclinical development and clinical implementation in addition the accessibility between countries of new treatments varies largely therefore the grasshopper consortium aims to create a multidisciplinary network of stakeholders in pediatric cancer development to boost implementation of new therapeutic interventions for children with cancer across europe and beyond grasshopper consists of 10 beneficiaries and 7 associated partners located in 16 countries 6 academic european comprehensive childhood cancer centers ccccs and 3 noneuropean ccccs 5 nonacademic national leading childhood cancer centers 2 leading pharmaceutical companies and 1 nonforprofit drug developer the consortium has 4 objectives identification and preclinical validation of new immune interventions 1 and new molecular interventions 2 stimulating repurposing of available therapeutic interventions 3 and improving clinical validation of high potential therapeutic interventions for pediatric cancer 4 these objectives will be achieved by intersectoral secondments between the various beneficiaries and partners the consortium expects that these objectives will lead to a strong international and multidisciplinary network exchange of knowledge and expertise between sectors and countries and lead to highly skilled researchers trained in pediatric and transferable skills and with a large network for future career perspectives that will jump over the valley of death and accelerate new treatments
natureinclusive designs for reconciling offshore renewables with ocean protection

nid4ocean will advance the emerging field of natureinclusive designs nids and naturebased solutions nbs in general for offshore renewables by providing effective novel contextdependent solutions to industry managers and policymakers this will accelerate their implementation to support the achievement of the international and eu targets for carbon neutrality biodiversity restoration and sustainable blue economy three distinct european ecoregions north sea baltic sea and western mediterranean have been strategically selected due to their different technologies habitats ecosystems and sectorial conflicts with the development of offshore renewables an innovation challenge series will be developed to promote novel nids and nbs for each ecoregions wind and floating solar structures addressing issues such as design material choice noise and laying cables each ecoregion will use a transdisciplinary approach to develop contextdependent metrics and impact assessment frameworks to evaluate the benefits and risks of selected nids for offshore wind moreover data and monitoring requirements for evaluating the performance of nids will be identified to be later incorporated into recommendations towards standards an evidencebased decisionsupport tool will be cocreated with industry and managers to provide clarity on the selection process of nids in offshore wind farms finally a cocreated policy toolkit for the requirements of offshore wind development to comply with biodiversity protection and restoration targets will be delivered the nid4ocean consortium involving scientists industry smes ngos and the standardization community together with the establishment of the nid4ocean network will be key to an ambitious communication and dissemination strategy designed to reach all relevant stakeholders nid4ocean strives to raise awareness across stakeholders on the need to prioritize winwin solutions for biodiversity and decarbonization
carbon dioxide co2 storage in deep volcanic areas

co2sink aims at proving the effectiveness of an innovative co2 storage concept in deep volcanic areas that reduces the leakage risk humans need to take urgent action to achieve a climateneutral society among the necessary actions carbon capture and storage ccs will enable decarbonizing the hardtoabate industry which represents some 10 of the current co2 emissions and can even provide netcarbon removal if it is combined with bioenergy beccs or direct air capture daccs to effectively mitigate climate change ccs should scale up from the current 40 mtyr of stored co2 to the gigatonne scale by 2050 yet one of the main risks of ccs is co2 leakage because co2 is buoyant in the conventional concept of storing co2 in deep sedimentary formations the leakage risk can be significantly reduced by storing co2 in deep volcanic areas where water stays in supercritical state because at these pressure and temperature conditions co2 is denser than water and thus sinks therefore this novel storage concept if proven effective would improve the safety of ccs and would amplify the storage options we estimate that a few hundreds of wells could be storing co2 in deep volcanic areas by 2050 representing a storage on the order of 1 gtyr this storage capacity highlights the high gain of the proposal nonetheless injecting co2 in deep volcanic areas also entails high risks 1 potential longterm co2 leakage due to convective fluid flow and 2 potential induced seismicity above acceptable levels we will investigate the extent of these risks and propose mitigation measures to manage them we will disseminate and communicate the project outcome to the scientific community society policy makers and companies we plan to patent this storage concept if it is proved to be effective and will establish a commercialization roadmap with the advice of industrial collaborators and experts in knowledge transfer
producing novel nonplant biomass feedstocks and biobased products through upcycling and the cascading use of brewery sidestreams

biotechnology has the potential to reduce the impact of human activities in nature by developing new biobased production platforms towards a more efficient use of waste streams a step forward in industrial circularity can be achieved cheers is a new biorefinery concept inspired on nature biodiversity insect and microbial platforms to sustainably and efficiently upgrade underused or waste sidestreams such as bagasse wastewater co2 and ch4 from biobased industries into innovative biobased products cheers will help biobased industries to improve their feedstock use efficiency and overall sustainability and competitiveness via upcycling and cascading use of biomass produced from their sidestreams cheers is developed as a modular solution where biobased industries can configure their optimal combination by selecting among 5 novel biotechnological routes which generate 5 biobased products for industrial applications with attractive market opportunities insect protein disinfectant microbial protein ectoine and caproic acid all value chains are based on new bioprocesses andor innovative biofermentors combined with sustainable downstream processes which will be validated at demoscale at an industrial brewery a min 45 carbon footprint reduction will be achieved in each value chain the evaluation of cheers impacts will consider go beyond the classic lca and will cover broader impacts such as biodiversity and land use the beer company mahou is project coordinator and exploitation leader jointly with 11 partners of 5 european countries including technology suppliers endusers and research entities cheers will contribute to a zero waste biorefinery approach fully aligned with the eu green deal circular economy action plan and bioeconomy strategy and foster the understanding of biotechnologybased value chains through the engagement of relevant actors from small biobased industries to consumers
a renewable powertoheat technology to decarbonize heavy industry

heatrix is a young deeptech climate startup based in bremen germany our mission is to competitively replace fossil fuels in energyintensive industries by converting renewable electricity into storable process heat up to 1500c the heatrix system combines an innovative hightemperature electric heater utilizing offgrid solar or wind electricity with a thermal energy storage to provide continuous hightemperature process heat with zero emissions our modular approach where heater and storage are fitted into standardized container systems enables rapid deployment and easy integration into existing plants with minimal retrofitting requirements we combine cuttingedge scientific findings with mature technologies and equipment to benefit from economies of scale customers can implement heatrix in a phased approach in line with market demand for green products and the availability of renewable electricitygiven the complexities of our technology and the challenges to build a successful startup supporting programmes such as the woman techeu are invaluable the grant will allow us to build more confidence towards our technology for future customers we plan to use the grant to attract industry partners and strengthen our relationships by collaborating on first feasibility studies to evaluate integration possibilities of the heatrix system in existing processes moreover the support of experienced mentors and coaches will help us to sharpen our business plan secure initial customers as well as build and grow highperformance teams gender equality is a matter of course to us and especially for me female ceo and founder of heatrix a heartfelt wish i am eager to get in touch and learn from successful female rolemodels to strengthen my teambuilding capacities and leadership skills
toward desirable metal organic framework mixed matrix materials through machine learningguided interface design

metal organic framework mixed matrix materials m4s are prototyped for many applications such as separating membranes drug delivery systems and firesafe plastics like all composites the premise of m4s is to achieve greater properties than those of their isolated components yet the interface between the components determines whether the synergy between the components is achieved or the overall performance is diminished due to their incompatibility in principle the interface can be designed by selection and chemical modification of the components involved however in practice such design is a very challenging endeavor atomistic simulations can predict the structure of the interface from which the component compatibility may be inferred similarly mechanical testing of the composites may reveal some qualitative characteristics of the interface nevertheless the throughput of these approaches is insufficient to screen the design space for the optimal m4s for various applications this project aims at developing the capability to computationally design m4s with good mechanical properties by employing machine learning techniques we will be able predict the properties of the interface in a highthroughput manner similarly our multiscale models will establish quantitative relationships between the interfaces and the mechanical properties of the composites which can be verified experimentally to achieve these objectives the researcher will be provided trainingthroughresearch in highthroughput atomistic simulation workflows material informatics and machine learning for material discovery as well as homogenization techniques and finite element approaches for multiscale modeling moreover this project will give the researcher an opportunity to apply her expertise to explore the area of composite design in both basic science and industryoriented perspective actively undertaken by imdea material institute
addressing critical gaps in mpox epidemiology in drc the movie and trace studies

this proposal outlines two linked studies aimed at addressing the public health challenge of mpox in the democratic republic of congo drc the movie study focuses on understanding the kinetics of viral elimination shedding light on how mpxv interacts with host tissues and immune defences which is crucial for developing containment strategies and potentially influencing endpoint selection in therapeutic trials the trace study aims to determine secondary attack rates in mpxv outbreaks assessing host susceptibility within specific populations offering vital data to target interventions towards vulnerable groups and informing vaccine efforts by contributing to the assessment of vaccine efficacy endpoints
datadriven integrated syncromodal collaborative and optimised urban freight meta model for a new generation of urban logistics and planning with data sharing at european living labs

disco will develop and demonstrate in reallife conditions a federated european urban freight uf data space as one stop shop of data sharing on digital urban logistics solutions and smart tools for ambitious decision making it will be a continental tent oriented and distributed reallife ecosystem to prove its value via demonstrated and replicable use cases ucs build upon innovation drivers to code concrete transformation of urban planning and land use by an open and collaborative uf data space with a smart governance modelthe disco uf data space is voluntary based incentivized cocreated and open framework to achieve a radical transformation and alliance in purposeoriented data sharing enabling smart access fast and resource efficient acquisition and focused provision improving knowledge and capacity of city authorities and planners guaranteeing future data availability for dynamic and predictive integrated urban logistics planning synchronizing realtime demand for transport warehousing with logistics supply eg as uber matches the demand for private car transport service with its road drivers fleetdisco will support european urban logistics players in reducing economic societal and technical dependence from private digital platforms owned by large global providers magnifying the scope of a sustainable urban mobility plans sumps converging to datadriven sustainable urban logistics planning sulps expanding them beyond traditional urban boundaries eg rural areas towns and suburbs cities and urban areas according to world urbanization prospects and beyond covid19 to optimally manage monitor and dynamically predict city freight flows changing urban nodes accessibility by properly serving functional urban area fua on a larger mixeduse and flexible scale and deliver advanced and wellinformed planning and purpose oriented optimised land use within a tent and global dimension