Dragon09/odtu_chatbot huggingface dataset:
complex contagion of childcare strategies amongst lowincome parents

background high quality childcare greatly improves outcomes in later life yet childcare access and usage are distributed unevenly leading to amplified inequalities in later life outcomes parents from lowincome households are 50 less likely to use formal childcare services than highincome households and use them when the child is older and less intensely research has shown that cost location and quality of childcare effects usage yet policy solutions aimed at removing these barriers have not reduced inequalities in usageaim in this project sociological economic demographic and social policy perspectives are synthesized within a framework of complex contagions to investigate how the use of formal childcare diffuses across low income populations with the aim of identifying barriers to uptake in formal childcareapproach this project breaks through the state of the art to more clearly describe why some childcare strategies that use formal childcare dont spread to low income households with a complex contagion people only adopt a new behaviour if they are repeatedly exposed to it from multiple diverse actors in their network low income households have personal networks with long weak ties and high multilayer clustering that make adopting new childcare strategies unlikely this project therefore examines how the childcare strategies present in work family and neighbourhood networks influences the childcare strategies of low income householdsinnovation impact the analysis will draw on unprecedented linked administrative and survey data to study the diffusion of childcare strategies network data are used in combination with multichannel sequence analysis and other longitudinal methods to identify the role of networks in shaping childcare strategies the project will completely reframe our understanding of not only childcare strategies but also parallel areas of social policy and the wider study of behaviour diffusion in
reassessing phosphorus removal by employing classical and fermentative metabolism of polyphosphate accumulating organisms in complex carbon environments

the urban wastewater treatment directive adopted by the eu acknowledges enhanced biological phosphorus removal ebpr as a sustainable process that prevents eutrophication saves marine assets estimated at 500 billion and counters depletion of phosphorus ore ebpr is mediated microbially by polyphosphate accumulating organisms paos but our understanding is limited to identifying ca accumulibacter as a globally dominant pao that utilises volatile fatty acids as carbon substrate however a variety of paos exists in fullscale wastewater treatment plants wwtp that display metabolic versatility in the assimilation or fermentation of complex carbon substrates such as amino acids and sugars the remapcarbon action will explore the metabolic versatility of paos using complex carbon substrates an interdisciplinary approach involving engineering principles multiomics analyses and advanced modelling techniques will be implemented under the supervision of prof mark van loosdrecht tu delft i will study the metabolism of paos using isotope labelling techniques kinetic and stoichiometric characterisation and metabolic models during the secondment at aalborg university with prof per nielsen i will gain complementary skills in bioinformatics and microspectroscopy techniques to extend ebpr application to complex carbon substrates in wwtps an industrial placement is planned at the end of the fellowship to exploit research outputs with royal haskoningdhv in leading international and intersectoral collaborations i aim to develop research skills project management and communication abilities to improve overall effectiveness as a researcher independently leading this action will provide me experience and confidence to undertake ambitious projects and collaborations in my academic career overall this action will contribute to europes knowledgebased economy by defining how paos turn the wheels of the biogeochemical phosphorus cycle in natural environments
production of a second phase of hydrophobic aromatics with solventtolerant pseudomonas

replacement of fossil chemicals with biological counterparts has been widely accepted as a vital pursuit to increase the sustainability of our chemical and material industries synthetic biology and metabolic engineering enable us to produce a plethora of chemicals with microbes but the majority of these never make it past the proofofprinciple stage this is especially the case for dropin bulk aromatics like styrene or benzene the main reason for this is that such products are too toxic to ordinary production microbes in prosper i aim to overcome this hurdle and demonstrate the efficient microbial production of hydrophobic aromatic chemicals using solventtolerant pseudomonas i will engineer this unique extremophile to break the solubility barrier of these chemicals forming a second phase of product this second phase provides a virtually endless product sink and it enables extremely simple downstream recoverythe biobased production of a second phase of such chemicals has thus far never been shown i believe that this relates to a fundamental problem in biotechnology production tolerance ie tolerance of the producing organism to the produced product rather than to an externally added chemical as it is usually studied in prosper i intend to generate deep mechanistic insights into the processes governing both types of tolerance and to leverage these insights to open up a new field of biotechnological production of hydrophobic compounds to achieve this i will develop new methods to analyze intracellular solvent concentrations build a pseudomonas chassis with enhanced production tolerance to hydrophobic solvents and enable production of solvents like styrene ethylbenzene and even benzenei am in a unique position to achieve this goal with over 15 years of experience in the engineering of pseudomonas as a workhorse in biotechnology the study of solventtolerance and the development and application of synthetic biology tools and metho
lithium ion batteries a microscopic view

lithiumion batteries libs play an important role in our daily life with a variety of applicants to this day significant resources have been dedicated to the development of highperformance libs particularly the research necessary to identify the optimum electrolyte materials to solve the safety issue up to this point polymer electrolytes are widely investigated for their potential to improve batteries safety given the relative high ionic conductivity around 103 scm polyethylene oxide peo is frequently utilized as the polymer matrix in this scenario but compared to the commercial liquid electrolyte the ionic conductivity of polymer electrolyte needs to be improved for at least ten times it is widely acknowledged that the transportation of li is directly related to the segmental and backbone motions of the polymer indicating to improve the ionic conductivity by structure optimization of polymer instead of using the traditional trial and error method modern innovative studies intend to develop a microscopic picture of the liion transportation process to instruct the polymer optimization but it is difficult with inhouse laboratory methods this project aims at designing a polymer with high ionic conductivity to achieve this goal the microscopic view of li transportation in polymer will be elucidated through molecular dynamics md simulation and the polymer dynamics will be clarified with md simulation and quasielastic neutron scattering qens
analogue inmemory computing with advanced device technology

every day we generate process and use a massive amount of data searching a keyword on the internet choosing a movie for the weekend and booking our next holiday are just a few simple actions that rely on dataintensive algorithms in the cloud such as data search recommendation and page ranking the energy cost of computation is high it has been recently reported that training a relatively large neural network produces the same carbon dioxide of 5 cars in their whole lifetime data centres use an estimated 200 terawatthours each year corresponding to 1 of the global demand with the spectre of an energyhungry future it is essential to identify novel concepts novel algorithms and novel hardware for streamlining the computing processmy preliminary research has shown that computing energy requirements can be reduced by closedloop inmemory computing climc that can solve linear algebra problems in just one computational step in climc the time to solve a certain problem does not increase with the problem size in contrast to other computing concepts such as digital and quantum computers thanks to the sizeindependent computing time around 100 ns climc requires 5000 times less energy than topclass digital computers at the same bit precision these preliminary results show that climc is a promising new computing concept to reduce the energy consumption of data processingmy project will develop the device technology the circuit topologies the systemlevel architectures and the application portfolio to fully validate the climc concept a novel memory technology that is immune to wire resistance effects will be developed climc integrated circuits will be designed with standard cmos technology systemlevel architecture and application exploration will further support the scalability and feasibility of the concept to demonstrate climc as a primary contender among the computing technologies with improved energy efficiency
melt electrowriting of multilayered scaffolds for osteochondral defect repair mems

an osteochondral oc defect is a focal area of joint damage that involves both the articular cartilage and the underlying subchondral bone such joint damage is strongly associated with the development of premature osteoarthritis motivating the development of novel strategies to regenerate oc defects 3d printing is enabling the manufacturing of geometrically complex biomaterial implants with user defined compositions and architectures which can potentially be used as single stage offtheshelf scaffolds for treating complex injuries despite significant progress in this field 3d printed scaffolds capable of regenerating oc defects remain elusive this can potentially be linked to the spatial resolution possible using traditional additive manufacturing techniques the melt electrowriting mew technique has recently emerged as a novel additive manufacturing platform capable of producing polymeric scaffolds with fiber diameters in the submicron range in a highly controllable manner we have recently developed mew scaffolds that support superior bone regeneration compared to scaffolds produced using traditional additive manufacturing techniques furthermore we have generated preliminary data demonstrating that multilayered scaffolds generated by mew are capable of enhancing the repair of critically sized oc defects in a preclinical large animal model the mems project aims to further enhance the regenerative capacity of these mew oc scaffolds by i optimising their architecture and ii functionalizing their surface with extracellular matrix ecm components supportive of tissuespecific regeneration the output of mems will be an offtheshelf implant capable of directing endogenous oc defect regeneration without the need for delivering exogenous cells to the defect site
entanglement of an array of massive magnetically levitated superconducting microparticles on a chip

quantum states of massive objects have fascinated us since the inception of quantum mechanics nowadays molecules of thousands of atoms and nanomechanical resonators weighing picogram can be brought into quantum states this capability enables tests of the validity of quantum mechanics and provides new avenues for quantum technologies entangled states are particularly relevant in this context as they unlock multipartite quantum correlations that amongst others enable precise measurements beyond the standard quantum limit and novel tests for the interplay between quantum mechanics and gravity however no experiment to date demonstrated entanglement between a scalable number of massive particles which would access a novel parameter regime in terms of mass quantum correlation and particle number superqlev will fill this gap and demonstrate entanglement of the centerofmass motion of an array of magnetically levitated superconducting microparticles on chip this achievement will break new ground by exploring multipartite quantum states of massive objects ranging over six orders of magnitude in mass from pico to microgram superqlev will make this possible by merging two technologies into a unique experimental platform the first technology is magnetic levitation of superconducting microparticles which offers the capability of levitating massive particles at ultralow mechanical dissipation my group has made pioneering contributions by realizing chipbased magnetic levitation of superconducting microparticles the second technology is superconducting quantum circuits that offer a versatile toolbox for quantum control superqlev will merge these two platforms to reach quantum control over the motion of levitated superconducting particles via inductive coupling to superconducting circuits this hitherto unexplored hybrid quantum platform allows superqlev to conduct groundbreaking proofofprinciple experiments in quantum sensing and fundamental physics
thematic european rural bioeconomy network therbn

the objective of therbn is to put into operation an euwide multiactor ma thematic network tn for knowledge sharing on innovative solutions for sustainable circular bioeconomy cb applicable by small farms and foresters practitioners at a local scale in rural areas such a framework will contribute to empowering practitioners pps solving the gap between available and viable cb solutions and the problems they face in their everyday starting from their most urgent needs on the management and use of biological byproducts and residues therbn will identify existing solutions from grassroots from pps innovations developed by operational groups ogs and research applied results from national and eu projects to produce practiceoriented easily understandable materials to be shared in national and eu demo days and training and through channels most consulted by pps therbn tn will assure open access to longterm digital structures like eufarmbook and eucap network complemented by the therbn platform to facilitate multilanguage access and a social environment to interact among and integrate cbinterested ogs tns project communities thus enhancing the crossborder dimensions and effects of therbn tn and reducing the fragmentation in knowledge and innovation the ma therbn tn will connect with the key actors researchers advisors innovation brokers and structures national and regional akis extension services advisors networks necessary to encompass the transition of small rural farms and foresters towards climate neutrality and more sustainable and resilient operation bottomup mabased dialogue will yield evidence on the current pps needs the remaining gaps for cb solutions that new innovative products and services can cover and policy briefs proposing policies or instruments to support the adoption of smallscaled cb solutions by small farms
lowdimensional ferroelectrics for advanced electronic and biomedical devices

the felowd project at the institute of solidstate physics of the university of latvia issp ul aims to boost research in lowdimensional ferroelectric fe materials for electronic and biomedical applications this research field is now burgeoning due to multiple discoveries of novel functionalities and various applications of fes in ambient energy harvesting flexible sensors smart implants piezocatalytic devices scaffolds for tissue regeneration and many more this initiative plans to establish issp ul as a leader in this field by creating a stateoftheart research laboratory and making structural enhancements for sustainable growth by appointing an outstanding era chair holder dr andrei kholkin h66 felowd will attract top talents prevent braindrain and promote open knowledge sharing within research innovation system focusing on industry collaboration and intensive transition from lab innovations to market viability the project will significantly contribute to european research area objectives through its dedication to advancing lowdimensional ferroelectrics felowd will ensure the development of novel fe materials and structures with exceptional performance providing pathways to nextgeneration technologies for localized energy sources smart biomedical systems wearable sensors piezoelectric scaffolds etc which will have a significant impact on scientific and technological development in latvia and europe the development of fe devices will definitively improve the european position in the corresponding markets and bridge the gap between fundamental research technology development and practical applications of lowdimensional ferroelectrics
discovery total chemical synthesis and validation of mirrorimage dnanobodies

the central role of molecularlytargeted therapeutics and imaging probes in translational research entails the development of an evergrowing arsenal of chemical biologics endowed with optimal in vivo properties in this regard mabs and their derivatives eg adcs still suffer from unsettled drawbacks involving difficulties in production and characterization leading to heterogeneous conjugates in terms of size potency and toxicity chemical modifications on mabs are highly unreliable due to their complex structure a central problem in this discipline where heterogeneous drugtoantibody ratio dar and conjugation site represent significative limitations immunogenicity is a major drawback which affects humanized as well as fullyhuman mabs and is exacerbated by long halflives cases of unwanted activation of the immune system reportedly degenerated to lifethreatening conditions such as acute anaphylaxis serum sickness and cytokine release syndrome their bulky size 150 kda hinders their extravasation impairing their efficiency to enter tumors nanobodies nbs are the smallest naturallyderived antibody fragments 1314 kda that retain antigenbinding affinities in the same range of mabs nm to pm affinity range while having extremely reduced halflives 15 min when not bound to their target thanks to a fast renal excretion mirrorbody intends to push the boundaries of targeted chemical biologics via an interdisciplinary approach that exploits both immunology and synthetic chemistry techniques for the generation of synthetic dnanobodies that bind natural ltargets with high affinity such unprecedented synthetic dnbs will be endowed with improved biocompatibility and will enable plugandplay approaches for the controlled conjugation of diverse moieties
digital tools to help agroforestry meet climate biodiversity and farming sustainability goals linking field and cloud

agroforestery af has already proven its potential for farm sustainability climate change mitigation adaptation biodiversity preservation and soil conservation however af performances are contextdependent and many barriers hinder its adoption such as lack of tools for decisionmaking assessing economic environmental social benefits and monitoring of policies and their impact on af digitaf will boost af implementation in the eu and beyond thanks to the codevelopment of digital tools tailored to the needs and concerns of digitaf target groups to engage actors whose decisions impact af implementationdigitaf will 1 support policyactors at various scales to design more efficient policies supporting af adoption carbon farming 2 provide tools helping practitioners farmers deal with the complexity of af systems digitaf will allow them to optimize the design and management of agroforestry systems at field and farm scale 3 enhance capacities of actors to assess quantify and market the economic environmental and social performance and benefits of afthe enduser centred multiactor approach of digitaf will be made possible by implementing 6 living labs ll in italy germany netherland united kingdom finland and the czech republic opensource tools will be codeveloped thanks to the existing or novel practical knowledge scientific evidence and models they will be tested with the endusers from ll and improved thanks to their feedback larger dissemination to target groups will be ensured through digitaf partners gathering members and networks across eudigitaf consortium brings together 25 partners from 20 countries from the eu associated countries and beyond composed of rtos 9 universities 5 smes 6 european and international organisations 4 ngo and cooperative 1 digitaf consortium and the ll cover all af value chain actors thus efficiently supporting af implementation in the eu
communitydriven farming for the atlantic and arctic sea basins through regenerative aquaculture

to restore and protect ocean ecosystems within a sustainable blue economy in line with the objectives of the mission restore our ocean and waters by 2030 we urgently need new business models for regenerative aquaculture informed by best scientific evidence on environmental impacts and developed in partnership with societal stakeholders to encourage adoption such practices must be technically operationally and economically viable for ocean farmers with clear benefits to ecosystem services community resilience market potential and job creation cfaarer will deliver a roadmap and guidance codesigned with stakeholders to support ocean farmers in the atlantic and arctic sea basin to develop communitydriven business models for regenerative ocean farming and policymakers to take enabling actions cfaarer builds on prior eu projects reviewing evidence on socioeconomic and environmental impacts and successful community business models to establish a robust case for adoption working with ocean farmers and coastal communities at sites in norway and ireland we will analyse technical operational economic environmental and social needs and create guidance on developing sitespecific communityled business plans we will codesign feasibility reports and evidencebased business plans with members of the norwegian seaweed association cluster of 80 ocean farmers replicate lessons via a new irish seaweed association and ensure longterm sustainability through a new community of practice on the established connecting nature enterprise platform policy recommendations will highlight barriers supports and investments needed from local national and eu authorities to strengthen and scale regenerative communityled aquaculture in the atlantic and arctic sea basin clustering and engagement with ocean mission projects and partner networks will identify opportunities to embed communityled business models for regenerative aquaculture in future mission actions