Dragon09/odtu_chatbot huggingface dataset:
simulation tools for the design of safe and sustainable lubricants

sitolub project aims to develop a digital toolplatform for the safe and sustainable by design formulation of new lubricants the tools developed will provide assessment of the safety toxicity to humans ecotoxicity to environment and workers risk and at the same time sustainability guidance to design ecofluids coolants greases oils in a clear and holistic way regarding the foreseeable physicochemical properties and tribological performance the safety assessment will be realized by using molecular dynamic models developed by the partnersthe tribological models will allow the prediction of the energy consumption during use by providing friction force values and expected durability of the materials by using wear data about the materials in contact with different fluids they will also provide information about tthe degradation of the fluids in use and the chemical reactions occurring the models will be flexible enough to predict the behaviour of the materials for different working parameters applied for different applications wind turbines electric cars and waterborne this ambitious and forwardthinking system will leverage on a series of tools ranging from technical evaluation and prediction models computational models supported by artificial intelligence combined with established lifecycle analysis lca methodologies to consider the environmental social and economic impactthe project will move in close collaboration with already funded european projects as itribomat h2020 ga 814494 for the creation of a oitb for tribological materials ontocommons h2020 ga 958371 for the standardisation of data documentation across all domains related to materials and manufacturing and iriss horizon europe ga 101058245 the international ecosystem for accelerating the transition to safeandsustainablebydesign materials products and processes
aristos postdoctoral program in biomedicine and health sciences

aristos aims to be the next postdoctoral program in biomedicine and health sciences cofunded by the horizon europe marie skodowskacurie cofund scheme and the consorcio centro de investigacin biomdica en red mp ciber in spain with a total duration of 60 months it will offer 27 postdoctoral positions for three years each at ciber groups led by distinguished principal investigators through an open and meritbased recruitment procedure it will provide excellent opportunities for international intersectoral and interdisciplinary research and training under attractive working conditions ciber is a public research consortium that embraces 511 research groups which belong to more than 100 different affiliated institutions universities research centers and hospitals around spain it is currently employing more than 800 researchers and clusters some of the most important facilities of biomedicine research in spain directly participating in more than 17 technology and research platforms as a network of excellence is tasked with being a reference in research and innovation in spain and internationally fellows participating in the aristos program will have the opportunity to carry out a research project in on a topic related with disease prevention diagnosis monitoring and treatment and come closer to the private sector by collaborating with medical and healthcare companies during their secondments or special events like the entrepreuners dissemination days beyond the fellows training through their own research the aristos program will also provide to the fellows career enhancing opportunities through training courses in research techniques complementary workshops for transferable skills scientific meetings and conferences and the access to international scientific and clinical networks with the final aim to promote knowledge exchange and the mobility among the academic clinical and private sectors
the critical shift to singlecell formats in functional analyses of living cells

the incredible potential of cell and immune therapy cit is limited by technical challenges related to the standard analysis of immune cells in bulk which neglects their heterogeneity singlecell functional resolution is essential to understand the full potential of immune cells current singlecell technologies are limited lowthroughput highcost and lack robustness prohibitive for their implementation in cit rd manufacturing and patient stratification samplix is developing xplore an allinone multiparameter singlecell analyser and sorter for screening selection and expansion of immune cells based on functionality and potency xplore is a costeffective solution that delivers higher throughput and sensitivity than current solutions being compatible with cit research workflows unlocking the full potential of cit supports the faster and efficient development of new personalized therapies to treat serious diseases such as cancer autoimmune diseases and viral infections
making stratigraphy in the anthropocene tracing multidecadal pollution in the marine sedimentary record off the coast of granada alboran sea western mediterranean

all over the world pollution is one of the ultimate environmental concerns europes seas and coastal zones are heavily impacted by human activities resulting in significant pollution since the beginning of the industrial age and particularly since 1900 in europe this major concern is linked to cycles of development and use of new elements and compounds followed by identification of pollution levels and risks eventually leading to the implementation of restrictions on their use often through national european and international legal instruments yet there are critical knowledge gaps that can interfere with the justification and implementation of such policies one is the provision of stratigraphic data on the longterm historical impacts of such regulations on widespread environmental concentrations of target pollutants the pandora project will fill this void by providing an innovative approach combining highresolution data on heavy metal and microplastic concentrations over time determining possible sources of contamination and quantifying their effects on benthic foraminifera growth patterns and calcification the scope of this project is a shelftoslope transect of timeresolved stratigraphic archives recovered in the northern margin of the alboran sea western mediterranean
synthetic proteins for sustainable animal feeding

half of the protein directed towards animal feeding is wasted due to incomplete protein digestibility and the distinct amino acid profiles found in both plants and animals this generates serious pollution problems for our soils aquifers and atmosphere eg livestock contribute to 87 of total ammonia emissions in agriculture moreover eu faces significant challenges in providing adequate protein sources for animal feed 97 of soybean meal is imported 15 billionyear hence it is imperative to identify a sustainable solution for animal protein supply synfeed will demonstrate that by developing a new interdisciplinary technological approach it is possible to generate proteins that can produce a radical paradigm change in the way animals are fed highly reducing both the environmental impact and external dependence on raw materials of the eu using the broiler chicken as a model synfeed will i generate new precision nutrition knowledge proportion of amino acids to fulfil the requirements and dynamics of protein hydrolysis in the targeted species ii design several candidate sequences using this nutritional information by protein engineering techniques combining ai and molecular modelling iii generate these candidates in cellfree systems adapted to the final host and evaluate them in a new iterative procedure maximizing expression and digestibility potential iv optimize the sustainable biosynthesis of the selected protein with sustainable hydrogenoxidizing bacteria strains v evaluate the effectiveness of the protein in broilers productive performance animal health and welfare and reduction of nitrogen losses and the sustainability of synfeed solution with a life cycle assessment this groundbreaking approach will replace conventional animal feeding positioning the eu as a leader in biosynthetic protein generation promoting the emergence of biotech companies and reducing livestock environmental impact
revolutionised enhanced supply chain automation with limited threats exposure

rescale aims at designing building and demonstrating securebydesign supply chains to this end rescale will i automate the evaluation processes of both software and hardware components ii ensure that thirdparty segments are free from vulnerabilities iii offer effective audit procedures for cybersecurity testing and iv enable the construction of secure systems with the strongest possible guarantees overall rescale will systematically analyse and extend as necessary every hardware and software layer in a computing system and apply novel tools and methodologies at every step of the entire supply chain
cellfree synthesis and assembly of biomolecular condensates engineering properties functions and regulation

compartmentalization is a defining characteristic of life and has the potential to enable and improve engineered manufacturing routes in biotechnology many biomolecules like proteins and rna have the ability to spontaneously cluster in molecularly dense phaseseparated liquidlike assemblies termed biomolecular condensates biomolecular condensates are promising as synthetic compartments in cellfree reactions and living cells because they could provide programmable selfassembled spatial organization and rapidly appear or dissolve on demand however we are still lacking key engineering and characterization tools a fundamental understanding of how the unique material properties influence internal biochemistry and strategies to regulate these dynamic molecular assemblies i have recently discovered that different condensateforming proteins can be synthesized and assemble into liquidlike droplets in cellfree transcription and translation reactions run in a customdesigned microfluidic device this project will pioneer cellfree synthesis for the engineering and characterization of biomolecular condensates and engineer new synthetic compartmentalization strategies for cellfree systems and living cells first developing and taking advantage of a highly controlled microfluidic cellfree environment we will generate and characterize new synthetic compartments with tailored properties secondly we will specifically target molecules and reactions into the condensate phase and systematically study how condensate properties influence biological functions finally we will implement dynamic feedback control mechanisms that can autonomously adjust presence and functions of synthetic compartments in cellfree systems and in cells synsembl will break new grounds for applications of biomolecular condensates in material science and synthetic biology
nontargeted forensic multidisciplinary platform for investigation of drugrelated fatalities

the rapidly changing nature of the new psychoactive substance nps market and the overall large number of substances that need to be monitored have presented challenges for early warning activities in recent years since the number of illicit drug classes is growing exponentially over time the current challenge is no longer to search substances during an investigation but rather to provide a sort of preliminary identification of the substance as illicit ie to tag it as such especially when it is a new type of drug today several instruments equipped with uptodate libraries allow for the rapid identification of drugs of abuse however this approach suffers from four main problems 1 the instruments libraries are not updated regularly 2 the instruments do not easily overcome the matrix effect 3 npss are trafficked and sold in smaller doses making their detection and identification more difficult 4 routine methods of analysis during forensic analysis are no longer effective in screening drugs of abuse the parent drugs but also their metabolites due to the lack of structural information and commercial reference materials narcosis nontargeted forensic multidisciplinary platform for investigation of drugrelated fatalities will provide a set of features for fast robust and reliable multidisciplinary approach to harmonise forensic investigations by means of an uptodate and updateable diagnostic platform with the following key features 1 a set of selected orthogonal instruments operable both onsite and in laboratories ramansers ir hsi hrms will be adapted to be used with the narcosis platform 2 build a comparable and shareable crossorganisation reference spectra metaspectra database for faster detection and identification of drugs of abuse 3 create an aiassisted spectra management and integration toolkit for analytical measurements to support the eu early warning system to rapidly detect assess and respond to nps
agile conformance assessment for cybersecurity certification enhanced by artificial intelligence

according to the eu cyber resilience act hardware and software products are increasingly subject to successful cyberattacks leading to an estimated global annual cost of cybercrime of eur 55 trillion by 2021 this is due to a low level of cybersecurity reflected by widespread vulnerabilities and inadequate approaches for identifying and mitigating the rapidly and constantly evolving cyber threats and vulnerabilities as well as ensuring continuous compliance with regulations industry standards and best practices to reduce the impact of cyberattacks and increase the resilience of digital technologies it is essential to assess the conformity to security standards of ict products services and processes throughout their life cycle however the traditional conformity assessment process is predominantly a static and expensive onetime assurance activity that does not cater to the needs of agile product delivery which promotes continuous product updates and upgrades and often changes in requirements each such update opens doors to product vulnerabilities and consequently poses cyber risks for product users and companies reputation to avoid these issues it is essential to enable a partial and continuous lean recertification of ict products services and processes to empower manufacturers to prevent detect counter and quickly respond to cyber threats in response to these challenges the certifai project will develop an open software framework for costeffective aidriven continuous assessment and recertification of ict products and services paving the way for a more secure and trustworthy eus digital world building on the eu cybersecurity act certifai will leverage the established cybersecurity requirements standards and technical specifications to deliver an efficient approach for ensuring that a product once certified will continue to be compliant with relevant standards throughout its life cycle
flexible and switchable mofbased composites for gas separation

chemical separations are key processes in power plants and some industries like steel and iron manufacturing to this end energyintensive thermal methods eg distillation are currently used making up the 4555 of the overall industrial energy input hence a transition from thermal to adsorbentbased gas separation is indispensable to address the ec objective to become europe as the first climateneutral continent by 2050 however the low selectivity of the traditional porous materials currently used in industry eg zeolites carbons make them unsuitable to meet this goal dynamic mofs a class of hybrid crystalline materials of recent development show reversible framework rearrangements which may occur as a reaction to an external stimulus make them unique for gas separation they selectively adapt their pore structure to a specific gaseous component in a mixture yielding exceptional selectivity but lacking stability under industrial conditions the project entitled dynacomp flexible and switchable mofbased composites for gas separation aims to develop shaping strategies for dynamic mofs towards their implementation in gas separations of industrial and environmental interest eg co2ch4 co2n2 c2h2c2h4 and to determine the impact on framework dynamicity after supporting the project is pioneer in preparing microporous robust flexiblerigid composites of dynamic mof thin layers supported on traditional materials investigating their spatiotemporal phenomena in addition the activities described in this project will be my first steps as an independent selfsufficient interdisciplinar researcher and the outcome of the overall fellowship will place me in the leading position on a new and exciting research field with potential to tackle 21st century sustainability challenges this fellowship includes a 3month secondment at karlsruhe institute of technology kit to prepare composites using advanced lpe techniques
investigating methane for climate action

the im4ca proposal unites leading european methane experts in a concerted effort to establish the scientific fundament needed to bring the climate forcing of methane under control specific objectives are to 1 strengthen methane mitigation policy worldwide with actionable information on local methane emissions and key driving processes 2 provide the eu with the measurement and modeling capacity needed to monitor its methane emissions and assess its progress towards the 30 emission reduction target of the european methane strategy and the global methane pledge 3 explore and understand climate feedbacks on natural methane sources and sinks and 4 improve the accuracy of climate scenarios by resolving the controversy about the causes for the recent growth rate variations in global methane to achieve these objectives we address a selection of key uncertainties that have thus far limited the progress towards these goals by i building up critical new infrastructure for monitoring methane emissions in europe and tropical africa ii developing methodology for efficient use of existing and upcoming satellites for measuring methane and the land surface properties needed for characterizing and attributing its emissions and iii translating the knowledge obtained into reliable projections of future methane and efficient emission mitigation scenarios in doing so the im4ca project will enable a breakthrough in meeting the work program challenge of enhancing the quantification and understanding of natural and anthropogenic methane emissions and sinks it will provide enhanced european assessment capacity of short and longterm changes in methane sources and sinks integrating information from multi platforms and novel observations and transfer that capacity into actionable information needed to combat climate change
green chemistry and biotechnology approaches for the development of naturebased cosmetics

greencosmin aims to form a tight multisectoral and interdisciplinary network for the implementation of green approaches for natural resources exploration and exploitation towards the production of cosmetics extraction advanced phytochemical analysis and dereplication in vitro screening and biotechnological production technologies will be applied in the development of natural cosmetic ingredients and their incorporation into final products greencosmin will use the prior knowledge of the consortium in biodiversity exploitation and green chemistry extraction with innovative extraction media in lab and pilot scale for the discovery of extracts and compounds with bioactivity related to skin cosmetic properties antioxidant antihyperpigmentation antiageing antiinflammatory emollient antimicrobial prebiotic and safety to humans and the environment biotechnology approaches and microorganism assisted methodologies will be applied to produce active compounds both in lab and large scale active ingredients will be incorporated into final products with preformulation studies and lcaconsumer satisfaction analyses will be performed a balanced consortium of six academic partners in the field of natural products chemistry biodiversity biotechnology cosmetology and biology will efficiently interact with five nonacademic partners in the field of metabolomics biotechnology cosmetics and natural ingredients development among them three associated partners from biodiversity hot spots ensure the collaboration towards innovative results and secondments of researchers meaningful for their career and skill development and the foundation of strong collaborations to be retained after completion of the project finally greencosmin will provide training and transfer of knowledge to developing countries of the consortium such as mongolia tunisia french polynesia and vice versa as well
demonstrating transformative solutions to empower climate resilience towards improved public health status in the eu boreal region

climate change poses significant threats to human health and wellbeing impacting not only the eu boreal region but also europe as a whole the increasing frequency and severity of extreme events like floods wildfires rising sea levels and heatwaves have farreaching consequences for local communities the need to adapt to climate changes impacts and embrace transformative solutions has garnered recent political attention nevertheless recent extreme incidents such as the 2021 wildfires in the boreal region and similar events in europe have underscored the imperative of systemic actions and revealed the disproportionate vulnerability of already marginalized populationsthe aurora project aims to enhance resilience against health risks stemming from climate change and contribute to the overarching mission objectives it seeks to achieve this by developing a suite of tools capable of 1 monitoring climate stressors 2 creating climate and epidemiological models 3 generating forecasts via simulated scenarios 4 identifying climate change risks and vulnerabilities in the boreal region these risks will be complemented by a reliable aidriven technology that will 5 issue early warnings and recommend adaptive measures and naturebased solutionsthese components will form a robust decision support system providing specific recommendations the aurora consortium with its vast experience in research projects envisions active engagement with stakeholders throughout all project stages via living mission labs this engagement aims to foster behavioral change and showcase the projects solutions in 5 demo cities riga tallinn vilnius tampere pori and 3 replicant cities klaipeda joniskis jurmalathe knowledge and insights generated by aurora will be disseminated through clustering activities ultimately empowering local policymakers to make evidencebased decisions reassess strategies and develop management plans for climateresilient cities