Dragon09/odtu_chatbot huggingface dataset:
towards a functional continuum operating system

the unstoppable proliferation of novel computing and sensing device technologies and the evergrowing demand for dataintensive applications in the edge and cloud are driving a paradigm shift in computing around dynamic intelligent and yet seamless interconnection of iot edge and cloud resources in one single computing system to form a continuum many research initiatives have focused on deploying a sort of management plane intended to properly manage the continuum simultaneously several solutions exist aimed at managing edge and cloud systems through not suitably addressing the whole continuum challenges though the next step is with no doubt the design of an extended open secure trustable adaptable technology agnostic and much more complete management strategy covering the full continuum ie iottoedgetocloud with a clear focus on the network connecting the whole stack leveraging offtheshell technologies eg ai data etc but also open to accommodate novel services as technology progress goes on the icos project aims at covering the set of challenges coming up when addressing this continuum paradigm proposing an approach embedding a welldefined set of functionalities ending up in the definition of an iot2cloud operating system icos indeed the main objective of the project icos is to design develop and validate a meta operating system for a continuum by addressing the challenges of i devices volatility and heterogeneity continuum infrastructure virtualization and diverse network connectivity ii optimized and scalable service execution and performance as well as resources consumptions including power consumption iii guaranteed trust security and privacy and iv reduction of integration costs and effective mitigation of cloud provider lockin effects in a datadriven system built upon the principles of openness adaptability data sharing and a future edge market scenario for services and data
generating a 3d micro necroptosis induced myocardial infarction model

cardiovascular disease remains one of the leading causes of death worldwide with more than 4 out of 5 of these due to heart attacks following a myocardial infarction mi the loss of cardiomyocytes cms is irreparable due to their nonproliferative state following a mi one of the most promising forms of recovery is using therapeutic drugs since generating a new drug requires considerable amounts of money and animal testing there is a need for alternative models such as human induced pluripotent stem cell hpsc models hpscs provide an excellent platform to model cardiac disease although 2d models are too immature and currently 3d models are not viable for screening of therapeutic compound libraries to solve this i aim to implement a kill switch in a subpopulation of a 3d cardiac tissue that when triggered will induce necroptosis in the population simulating a localized heart attack integrating macrophages will improve the physiological relevance and ctntfucci cms will be used to monitor cm proliferationto generate this innovative dependable inducible model of mi using hipscs the project is divided into 3 achievable goals1generate a hpsc cell line with inducible kill switch system2integrate macrophages into microtissues induce the kill switch investigate response to localized cell death and cellular changes producing a scrnaseq timeline3incorporate ctntfucci cardiomyocytes to investigate cardiac regenerative therapiesi will receive stateoftheart genetic modification training to generate the cell line goal 1 immune cell generation and integration goal 2 and bioinformatic study to identify key pathways identified through scrnaseq data generated from the minimi model to trial cardiac regenerative compounds goal 3 this project will not only generate a reliable model of mi capable for screening of cardioprotective compounds but also a malleable model suitable for easy adaptation to other researchers interests
strengthening global cooperation and institutional capacities in subsaharan africa to facilitate implementation of the gh edctp3 programme

this proposal is in response to the gh edctp3 call for support to edctp africa office ao which is part of the edctp association secretariat based in cape town and hosted by the south african medical research council the aim of the proposal is to provide support for the operation of the ao to ensure optimal implementation and visibility of the gh edctp3 programme in ssa the ao will provide technical support promote networking activities southnorth southsouth ensure alignment of the funded activities strategic partnerships and increase visibility of the gh edctp3 this aim of the project will be achieved through several activities that include technical support for the design implementation and monitoring of capacity developing activities monitoring funded projects organising workshops and facilitating dialogue between african and european research entities and stakeholders the expected impact is a strengthened and improved delivery of the gh edctp3 programme in ssa the implementation of this proposed project will be structured into four work packages wp called project management wp1 capacity development and networking wp2 strategic partnerships wp3 and conferences forums and meetings wp4 through this grant the ao will contribute to the following impacts accelerated product development for fighting target infectious diseases facilitated preparedness against public health emergencies in line with one health increased visibility of aueu partnership in science ensured close alignment with ssa national research programmes and activities on target diseases and ri increased participation of ssa countries in gh edctp3 and increased participation of industry and private entities in product development and clinical trials in ssa to implement the project fully the ao will need a competent project coordinator four project officers a senior administrative officer and an office manager the project will be 2953000 euros
how do people perceive the 15minute neighbourhoods globally investigating public perception across developed and developing worlds

over recent years the novel concept of the 15minute city is gaining traction across europe and beyond due to the numerous benefits that it can yield for local communities although it builds upon previous urban planning movements and ideas repackaging them has contributed to extra attention when reinventing the desired neighbourhood structure at this time of global resource constraints climate change vulnerable settlements pandemics and social exclusion the concept promotes a proximitybased approach in neighbourhoods planning and design by which accessing daily needs for locals is guaranteed in a 15minute walkbicycle ride of their home while the fundamentals of the concepts are promising a prescriptive nature like its previous counterparts does not allow for understanding how popular it is for people and replicable across various contexts in fact much less is known about the applicability of this new approach with regard to diverse contexts and clients the present research project will thus shed light on exploring the way people perceive this novel planning and design approach in various urban contexts worldwide this research follows a casestudy design with an indepth analysis of public perception that is based on a combination of qualitative and quantitative methods the empirical study on contextsensitivity is conducted using predefined developed and developing cities represented by brussels and tehran respectively these findings contribute in several ways to our understanding of the 15minute city concept and provide a basis for future applications having multiple scientific social and environmental impacts on global communities in long term
breakthrough dualaction otc tablet for treatment and prevention of both bacterial and fungal vaginitis

there is a large unmet medical need for an efficient and highly accessible solution that can simultaneously treat and prevent bv and vvc while removing the abuse of antibiotic and antimycotic drugs to avoid further antimicrobial resistance the inefficacy of current solutions is demonstrated by the huge burden that bvvcc bring to the society in terms of economic expenses more than 38bn annually preterm births 54m per year the huge prevalence of both diseases more than 500m cases per year and the deteriorated qol for women gedea has developed phyph a patented pessary that due to its safe profile will be highly accessible as a first line otc solution phyph is an antimicrobialfree dual solution with a new mode of action that targets both the treatment and prevention of bv and vvc without the need of pathogen identification phyph will be commercialized as an otc product in pharmacies and drug stores where 90 of women with vi look for a treatment to the infection the business model targeted for phyph is a wellestablished and successful b2b2c model for this type of product our business model is highly scalable via planned partnerships with distributors and pharma companies that will facilitate accelerated commercial deployment scale up of our business throughout europe beyond gedea core team is composed by 9 persons with over 250 years of experience combined including experts in clinical research bioorganic chemistry regulatory affairs marketing and business development the company received the award rapidus company of the year and appeared on labiotechs list the 20 european biotech companies to watch in 2022during this project gedea will perform the necessary clinical trials cemark certification and premarket activities to commercialize phyph trl 9 by 2026 in order to do so gedea requires an estimated expenditure of 119m which is requested to the eic through both grant and equity fund
revealing the mechanics of subcritical rock cracking of mountains cliffs from environmental forcings by imaging stress cycles from dense acoustic arrays

the general idea that a rock mass cracks when the external stressloading exceeds the rock strength leading to catastrophic failure critical cracking is challenged when considering outcrop erosion many observations in the field and the laboratory evidence slow incremental crack developments well below the yield stress of the material for which repetitive stress load and fatigue induce progressive failure also called subcritical cracking it is largely accepted that the weather temperature changes rain frost is a major source of stress cycles and slow cumulative damage but the literature shows too limited quantitative field observations to confirm the mechanics behind rock outcrop cracking today we cannot predict rockfalls nor quantify the relation between daily or seasonal weather forcings to rock crack production and yet rock fracturing plays a leading role in most surface processes from landscape building to vegetation hydrology and natural hazard prediction there is an urgent need to reveal the mechanics of subcritical failure within rock outcrops fracturing processes initiate and develop at small scales from the grain size to a few mm and meteorological forcing evolve over daily to seasonal time scales but existing field observation tools hardly meet these scales in order to lift this issue the project will deploy an original active multisensory acoustic imaging technique on natural rock outcrops to map and monitor stress changes and crack production in m2m3time over timescales ranging from a few hours to a few months with a centimetric spatial resolution and a stress sensitivity down to a few kpa stress will be deduced from acoustic waves thanks to the acoustoelasticity principle allowing us to determine the physics of subcritical cracking of rock outcrops in their natural environment this work will pave the way for predicting rockfalls and further the impact of climate change on rock erosion
the age of age the rise of calendar age and sociopolitical age consciousness in early modern germany and italy c 1650 to 1850

modern western societies have coalesced around one way of thinking about human age calendar age ie the number of years since birth which shapes both how we think about agerelated behavioural norms and how we define for example access to retirement benefits despite its unrivalled importance calendar age has come under critical scrutiny amid recent debates on ageism in line with historical notions of gender or class it becomes increasingly clear that calendar age is not a neutral number but an impactful social categorywhen did calendar age rise to become such ubiquitous category and which factors contributed to this how did early modern age consciousness function before the rise of calendar age the project studies these two questions at the example of southern germany and northern italy between 1650 and 1850 based on a sample of burial records it shows how between the early enlightenment and the onset of the industrial era reporting ones age in calendar years became increasingly common as calendar age grew into a category to identify people driven by enlightenment notions of accuracy a significant share of early modern populations could report their age in calendar years this rise of calendar age supplanted an early modern age consciousness in which alternative ways of age reporting coexisted and whose degrees of accuracy depended on the specificities of context the project studies one such context to show how early notions of accuracy were culturally motivated and how information about birthdates and baptisms could actually be retrieved to enter guilds in early modern italy and germany young men had to prove their legitimate birth forcing them to research its circumstances and provide written documentation this production of birth certificates will be analyzed by comparison of an german and italian city by historicizing calendar age the project contributes to the fight against ageism and reflections on agebased norms
hybridelectric regional architecture

hera will identify and tradeoff the concept of a regional aircraft its key architectures develop required aircraftlevel technologies and integrate the required enablers in order to meet the 50 technologybased ghg emission set in sria for a hybridelectric regional aircraftthe hera aircraft having a size of approximately of 50100 seats will operate in the regional and shortrange air mobility by mid2030 on typical distances of less than 500 km interurban regional connections the aircraft will be ready for future intermodal and multimodal mobility frameworks for sustainabilitythe hera aircraft will include hybridelectric propulsion based on batteries or fuel cells as energy sources supported by saf or hydrogen burning for the thermal source to reach up to 90 lower emissions while being fully compliant with icao noise rules the hera aircraft will be ready for entry into service by mid2030 pursuing to the new certification rules able to interact with new ground infrastructure supporting new energy sources this will make hera aircraft ready for actual revenue service offering to operators and passengers sustainable safe and fast connectivity mean at low ghg emissionshera will quantitatively trade innovative aircraft architectures and configurations required to integrate several disruptive enabling technologies including high voltage mw scale electrical distribution thermal management new wing and fuselage as well as the new hybridelectric propulsion and related new energy storage at low ghg to support this unprecedented integration challenge hera will develop suitable processes tools and simulation models supporting the new interactions workshare in the value chain and interfaces among systems and components hera will also elaborate on the future demonstration strategy of a hybridelectric regional aircraft in phase 2 of clean aviation to support the high trl demonstration required for an early impact for hera solutions
constraints and opportunities for horizontal gene transfer in bacterial evolution

horizontal gene transfer hgt the movement of genetic material between individuals is a significant force fueling bacterial evolution through hgt bacteria acquire new traits develop new metabolic capabilities and learn to withstand harsh environmental conditions however in some cases hgt brings genetic information that is not advantageous to its host despite its crucial relevance for bacterial ecology and evolution understanding the selective forces that drive the success or failure of hgt remains a major challenge previous studies addressing this challenge ignored the fact that not all hgt events are alike incoming dna can be integrated into the host genome eg transposons integrons or it can stand as a physically separated autonomous dna molecule eg plasmids this difference in genomic context poses several mechanistic constraints that are likely to alter the evolutionary outcome of hgt here i will present a conceptually novel approach that explicitly considers genomic context to uncover the selective drivers of hgt in bacterial populations first i will develop a new genetic technology to obtain highthroughput fitness measurements of thousands of hgt events then i will use these data to identify and quantify the constraints that determine the success of hgt both considering the intrinsic effects of the transferred dna and the role of genomic context on host fitness specifically i will measure the fitness effects of genetic transfers mediated by plasmids obj 1 or integrated into the chromosome and in the latter case in different regions of the chromosome obj 2 finally i will leverage the rules derived from these analyses to reconstruct the role of hgt in the evolution of a relevant human pathogen obj 3 this project will provide a quantitative and mechanistic understanding of the selective forces driving hgt expanding horizons in evolutionary microbiology
wafer scale ultraclean van der waals heterostructures

two dimensional materials 2dm and their van der waals vdw heterostructures have opened new opportunities to developatomically thin electronic and optoelectronic devices with a wide range of functionalities while thousands of research papersdemonstrate proofofconcept studies with improved and novel performance using smallscale exfoliated crystals a number ofchallenges still remains when these are attempted to be scaled up on waferscale with cvd grown 2dm one of the key challenges isthe transfer process of 2dm from their growth substrate to another 2dm or a target substrate for intended use currently this processis performed using organic polymers to support 2dm which introduces considerable amount of contamination and mechanicaldamage to the transferred layerswe propose to circumvent the existing issues of the transfer process by employing a new technique recently invented in ngi whichcompletely avoids use of organic compounds this approach enables production of heterostructures with perfect interfaces free frominterlayer contamination and correspondingly excellent optoelectronic behaviour in addition eliminating polymeric supportsallows new possibilities for vdw heterostructure fabrication assembly at temperatures up to 600c and in different environmentsincluding ultrahigh vacuum uhv liquid submersion and improved mechanical stabilitythis project will apply our novel approach for waferscale use considering requirements of industrial companies such as the choice of2dms and wafers quality standards throughput and reliability the improved inorganic transfer technology will be then licensed to aselected 2dm foundry in addition we will develop an instrument for waferscale 2dm transfer that employs our innovative approachwhich will be made available via spinout company successful completion of the project can bring life to a wide range of industrialexploitation of 2dm in industrial nanotechnology applications
a micromotordriven triboelectric nanogenerator with different propulsion mechanisms

the triboelectric effect is always considered a negative phenomenon in daily life and this perception was altered when the first triboelectric nanogenerator teng was proposed in 2012 as a new energy source to date the tengs are well developed by thousands of researchers across the world utilizing human activities water waves wind and rain drops however there is still a gap between triboelectricity and other energy sources for example chemical energy and light inspired from natural immunocytes artificial micromotors mms referred to microscale particles capable of converting different energy sources into kinetic energy were well developed since 2004 the objective of this project is to apply mms in teng design mmteng as an alternative strategy for electricity generation which is expected to build up a bridge between other energy sources and electric energy through triboelectricity the project will focus on i the fabrication of the dielectric mm and the motion analysis under required circumstances with different propulsion mechanism ii the assembly of a freestanding teng with metal electrodes and electrifiable polymer membrane iii the measurement of the triboelectricity converted from different energy sourcesthis interdisciplinary project will be supported by i a worldrenowned expert in micronanomachines and electrochemistry prof martin pumera as the host and the facilities at central european institute of technology ii colleagues specialized in electrochemistry and triboelectricity iii excellent trainings for both scientific skills and soft skills workshops and seminars together with the researchers own experiences in mmsin research aspect it is always of great importance to develop new energy sources in career aspect with the international working environment and the inspiring research topics in the interdisciplinary field this project will be a boost to the researchers future academic career
provision of integrated computational approaches for addressing new markets goals for the introduction of safeandsustainablebydesign chemicals and materials

safeandsustainablebydesign materials and chemicals admaschems are a central requirement for reaching the ambitious goal of making europe the first digitallyenabled circular climateneutral and sustainable economy pink will provide an open innovation platform supporting industry byinnovate new computational approaches for admaschems development and for assessing their safety and sustainability performances by a integrating data and predictive models and b complement them with new ai techniques for data searches integrate these into a computational ssbd framework by translating industrial requirements and new market demands into decision support as well as training and skill development needsprovide an integrated platform the pinkish platform providing decision support based on advanced data visualisation and generative ai technologies based on all generated datafairify the information exchange along the valuechain and life cycle of admaschems by developing an advanced interoperability framework sharing the corresponding approaches and fair tools with the communities and making data models workflows and software fair and whenever possible publicly availablevalidate the newly developed pink models and software as well as the pinkish platform on two developmental casestudiesboost the innovation capacity of industry in general and that of smes in particular by making all pink innovations accessible promoting the costeffective tools further demonstrate these in a number of industrial demonstrators and encouraging their sharing and use through dedicated training and skillsdevelopment this will be the starting point for implementing a business plan for commercialisation and longterm sustainability of the platformthe pink project will run for 48 months it is organised in 6 work packages wps representing the tasks above 1 wp for initiating community outreach refine and 3 coordination and dissemination wps