Dragon09/odtu_chatbot huggingface dataset:
mechanisms linking earlylife stress and resilience to climate change in amphibians

climate change imposes a myriad of environmental stressors to wildlife that are particularly challenging to early lifestages in animals with complex life histories such as amphibians poor developmental conditions have been shown to impact survival later in life as amphibians are the most threatened vertebrate class identifying mechanisms that shape their capacity to cope with environmental stress is vital for predicting population responses in amphistress i aim to investigate how earlylife stress can affect resilience to climate change in amphibians by exploring the underlying neuroendocrine and physiological mechanisms mediating the interplay between environmental change behaviour and stress physiology hereto i will employ an interdisciplinary approach exposing amphibian larvae to suboptimal developmental conditions elevated temperature pond drying hypoxia and first assess the resulting impact on glucocorticoid stress hormone levels oxidative stress animal personalitycoping style growth and shortterm stress responsiveness before and after metamorphosis then i will assess the movement behaviour of juveniles toads under seminatural conditions to understand if earlylife stressinduced altered growth trajectories interact with dispersal capacity lastly i will build heuristic models to identify how individual stressresponses to climate change can scale up to affect population dynamics amphistress will provide novel information on the effects of climate changeinduced habitat alterations on amphibians and the importance of habitat connectivity for amphibian dispersal survival and population persistence thereby generating knowledge with direct conservation value finally this project will be the cornerstone of my longterm research goals to link developmental conditions and lifehistory trajectories in an ecoevolutionary framework and would provide me with a unique opportunity to strengthen my scientific profile to advance my career
endothelial metabolism dictates the bone marrow niche and the plaque microenvironment

inflammation is an important driver of atherosclerosis the primary cause of global morbidity and mortality in emerging and developed countries new strategies to reduce atherosclerotic cardiovascular disease cvd risk are therefore eagerly needed i recently found that atherogenic inflammatory stimuli rewire cellular metabolism in endothelial cells ecs and thereby contribute to atherosclerosis progression defining the intricate link between ec inflammation metabolic rewiring and functional consequences for the vasculature will open new avenues for therapeutic strategies in cvd my recent work shows that cvdassociated metabolic changes in ecs can affect their secretome in turn the endothelial secretome disrupts both stem cell function in the bone marrow niche and macrophage activation in the plaque microenvironment two highly vascularized tissue compartments that drive atherosclerosis progression based on these findings i hypothesize that cvdassociated ec metabolic changes impact the micromilieu in both tissue compartments propagating the proinflammatory state in cvd patientswith this erc project i aim to define 1 how ec metabolism is affected in atherosclerosis 2 3 what the impact of altered ec metabolism is for stem cell function in the bone marrow niche and for macrophage activation in the plaque and ultimately 4 to define how interventions in ec metabolism improve tissue function and halt cvd developmenti will apply innovative 3d organonchip models that accurately reflects the human bone marrow and plaque microenvironment by combining this with a unique collection of human exvivo atherosclerotic plaques human bone marrow cells and novel transgenic invivo models i will generate essential new insights that help to understand the development of atherosclerotic cvdhereby this erc will yield important insights that the field urgently awaits to develop novel therapeutic strategies for the reduction of the burden of cvd
electrocatalytic production of liquid organic hydrogen carrier and chemicals from lignin

epoch proposes to develop a novel approach in linking green hydrogen production with the direct loading of liquid organic hydrogen carriers lohc enabling a transformative logistic of green hydrogen distribution and storage lignin derivatives are used to be selectively oxidized compared to water electrolysis epoch will advance the field by 1 using the nascent hydrogen at the cathode directly to load lohcs allowing economic h2 storage and transport and 2 converting at the anode waste lignin and its derivatives via selective oxidation epoch is beyond the stateoftheart solutions as it does not form molecular h2 at the cathode nor generates oxygen at the anode by modifying both cathodic and anodic reactions epoch reduces the energy intensity epoch will enable better cell performance and enhanced addedvalue device operations by i improving energy efficiency ii allowing cost reductions and iii intensifying the process the epoch device will be designed for flexible integration with biorefineries and pulp paper industries to valorize their lignin waste streams thus linking these industrial sectors and h2 economy epoch will allow the production of green h2 in areas where renewable energy production in the energy mix is higher therefore epoch will offer a new path to effectively decrease the carbon footprint of energyintensive industriesdevelopment of the novel epoch electrocatalytic device requires a advanced components electrocatalysts electrodes electrolytes and ionic liquid promoters membranes and b validation of the full module cell operation at laboratory scale thus our project integrates multidisciplinary topexperts in areas such as electrocatalysis lignin chemistry and materials synthesis with a large engineering company and a spinoff company on energy transition and a sme worldleading the lohc technology development and logistic
postrepatriation collaborative methodologies to enhance multivocality

the research project postrepatriation collaborative methodologies to enhance multivocality acronym collab4multi speaks to the indigenous research methodologies and partnerships in communitybased research in academia and beyond it strives to explore the recently recovered archaeological material from the nunalleq site 14001675 ad in southwest alaska in close collaboration with nonacademic research partners including indigenous artists and young culture bearers the precolonial history of the yupik is poorly known from the archaeological point of view most of what we know about it comes from the nunalleq site it is therefore important that the interpretations of the nunalleq collection be multivocal and produced combining the strengths of western archaeological science with indigenous knowledge systems and worldviews advocating for multivocality and decolonisation of academic research this project will critically analyse the resocialisation of cultural heritage in and by the living community the research programme of the project rests on a series of artsbased workshops to study this worldclass collection of yupik people and recreate the lifestories of its artefacts together with indigenous research partners the project will also explore the collaborative ways of knowledge coproduction and dissemination by developing and piloting cowriting methods informed by indigenous epistemologies the practical outcomes will contribute to the advancement of collaborative methodologies in archaeological and museological research with and for indigenous communities across the arctic region
innovative algorithms for applications on european exascale supercomputers

new architectures for exascale and postexascale computers will have massively parallel and heterogeneous processing capabilities that will require the complete redesign and reimplementation of the used algorithms to fully exploit the possibilities of these supercomputers the objective of the inno4scale project is to promote the efficient use of european hpc systems by identifying and funding the most promising novel algorithms for applications through this action the project will facilitate the design and development of highly efficient application software for european exascale computers the most successful of which should later be taken up by science and industry resulting in important performance gains the project will design and implement a call for proposals based on the cascade funding mechanism financing the most promising ideas on novel algorithms for applications to fully exploit and benefit from these valuable european exascale resources proposals received will be evaluated by external experts based on their potential innovation and impact on the upcoming exascale era and the castieleurocc2 and prace networks will be used to ensure the widest possible reach of the call the inno4scale consortium made up of two major european hpc research centres and two experienced partners in managing hpcrelated programmes is in the ideal position to carry out the project in an effective and efficient manner the results of the selected innovation studies that will receive more than 4 million euros in total include the development and publication of the novel algorithms to reduce the timetosolution or energytosolution of existing computing problems as well as to provide novel approaches for largescale projects in this way the inno4scale project will contribute to the realisation of the eurohpc ju overall objectives and those specific for this call as well as enable an optimal exploitation of european exascale and postexascale hpc systems
green valorization of co2 and nitrogen compounds for making fertilizers

confeti project proposes the development of a labscale validated innovative technology that is able to utilise and electrochemically convert co2 and n2 directly from air or flue gases without the use of critical raw materials and using renewable energy sources by the production of urea from n n2 andor no3 and co2 the project aims to ensure a circular and renewable carbon and nitrogen economy by recycling and converting the no3 not consume by the plant into ammonia or urea using photocatalytic technologies based on sunlight the technology proposed in the current project to synthetize and deliver urea fertilizer to plants will follow sustainable agriculture models by promoting the efficiency of available resources the sustainability of the agricultural sector the preservation of the environment and the safety and quality of products for many countries agriculture is the dominant sector in developing the economy increasing productivity and the modernization of agricultural production systems are the primary drivers of global poverty reduction and energy
sustainable powder materials for zinc rechargeable batteries

easyls patented technology provides green processes to locally produce critical powder materials used in zincbased batteries we use a mechanical process to create calcium zincate powder active material that can store electricity with only water as solvent and have the knowhow for the green production of titanium nitride essential conductive additive these innovations are combined to produce 3 readytouse composite powders zincatin znni batteries zincatair znair batteries zincatem znmno2 batteries easyls production processes for these powder materials and composite powders will be licensed to industrial powder producers and battery manufacturers respectively our current technology has been tested with our team specialized in prototype cells allows for the production of batteries with a capacity of 1000 chargedischarge cycles while retaining 70 of the cells capacity we intend to reach 3600 cycles by the end of this project of 5000 in later generations
rewiring transcriptional regulation by the prc2 complex using proximity inducing pharmacology

polycomb repressive complex 2 prc2 which incorporates repressive methyllysine marks on histone h3 to facilitate global transcriptional repression is an integral epigenetic modifier in normal development components of this complex especially ezh2 are hyperactive or overexpressed in a broad range of cancers resulting in excessive silencing of tumor suppressor genes tsgs moreover cancers with defects in the swisnf complex the most frequently mutated chromatin regulatory complex in cancer are dependent on prc2 function for survival while inhibition or degradation of prc2 components have become extremely attractive approaches to cancer therapy they still suffer from suboptimal kinetics and perturbation because they must rely on opposing epigenetic modifiers and transcriptional regulators to derepress expression of silenced tsgs thus i aim to overcome this issue by leveraging the cancer driver itself to derepress silenced tsgs in this regard i will utilize a highthroughput protein recruitment screen coupled to nextgeneration sequencing to identify proteins effectors that when recruited to prc2 can rewire its function to directly derepress a prc2silenced locus this screen will be used a base to develop novel proximity inducing compounds which can rewire the function of prc2 the compound that produces the strongest transcriptional derepression and antiproliferative effects in cancer cells will then be characterized via transcriptomics and chromatin profiling to determine its effects on endogenous gene expression ultimately this study will establish a new class of prc2 targeting compounds that will pave the way for improved cancer therapies which both inhibit prc2 methyltransferase activity and directly derepress prc2silenced tsgs
robust control strategy for dynamic lane change of intelligent articulated heavy vehicle in complex traffic environment

the complex traffic environment with dynamic changes of speed and acceleration of multisurrounding vehicles and adhesion coefficient and curve radius of the road results in that the optimal and precise control of lane change for intelligent articulated heavy vehicle iahv is difficult to be achieved according to the realtime states of multisurrounding vehicles and road parameters the realtime safe optimal trajectory of lane change is obtained by setting the multiobjective function considering efficiency jackknife yaw and roll stability the dynamic thresholds of each control mode which are modified by realtime trajectory and road parameters are obtained and then the multimode switching mechanism is established by deep neural network the vehicle parameters and states are accurately estimated by using an estimator with multiestimation algorithms combining steady state with dynamic state considering the parameter uncertainty a robust control strategy based on a linear parametervarying model is designed to realtime achieve precise and optimal tracking control of dynamic trajectory and maintain vehicle stability by optimizing weight coefficients and multimode switching thus the safe and optimal lane change of iahv under normal and extreme conditions with different velocities and loads is realized the proposed control strategy is verified on hil bench the research results will provide theoretical basis for iahv control in complex traffic environmentthis project provides a unique knowledge exchange from leading experts in different fields vehicle control mechanical transportation optimization motor pneumatic to solve the challenges in iahv the fellow will benefit from not only the scientific impact of the work but also exposure to new techniques and collaborative networks in different disciplines the dedicated training and high scientific value will help the fellow to become an independent researcher in a worldleading institution
circulating light on any photonic platform

the new technology envisioned in circulight will establish a breakthrough in photonic integrated circuit pic capabilities with impact across a wide range of applications of high economic and societal value it will lay the foundations of a new class of pics which are highly functional miniaturized and low powerconsuming as well as being manufacturable at low cost thereby contributing significantly to environmental protection and related quality of life the essential building block that will be created in this project is a truly integrated optical circulator which protects active and passive integrated functions from each other distributes light between them and finally allows very large scale integration of photonic components within diversified pic architectures the practical realization of such a structure will be a worldfirst and a breakthrough in pic technologycirculight technological decisive progress is based on magnetooptical mo nanoparticlecomposite solgel material and on magnetobiplasmonic mbp effect which will enable the monolithic insertion of circulators on any photonic platform within the project a demonstration will be made on two of them based on inp and si respectively operating at 13 or 15 m while pic foundries rely on specific and independent technologies our solution will bypass these specificities thanks to a universal integration of functional materials in addition our interdisciplinary approach is based on the analysis of real world needs feeding the cocreation of an exploitation roadmap together with end users industrial and societal stakeholders in preparation for the scaling up of our technology developments to transform society for the betterto reach these objectives our consortium of nine partners encompasses competencies in material sciences photonics plasmonics pics technology and social science and includes two smes
green science at the service of healthy society

the greensci project aims to increase the public recognition of science promote young researchers and researchers with sustainable innovations and show the impact that research and innovation have on daily life and social welfarein this context the 2022 and 2023 editions of european researchers night aim to increase the public recognition of science promote young researchers and experienced scientists with sustainable innovations and show the opportunities in research and steam for young people and pupilsthe main idea of greensci project is to bring together researchers innovators children young people adults from different regions of moldova who have and who do not have a background in research in order to show the impact of rdi and steam disciplines on everyday lifethe specific objectives of the greensci project arecontribute to increased visibility and promotion of research and researchers among the general publicenhance communication between researchers and the general public mainly young people by encouraging citizens engagementincrease the public recognition of eu programmes and opportunities including eu funded researchers from moldova as well as moldovan scientific diaspora promote innovations with social and business applicability via open science practicesemphasize the impact of research and innovation on daily life and social welfare
strict protection restoration and comanagement of marine protected areas to ensure effective ecosystem conservation and improved connectivity of blue corridors

the blue connect project addresses the urgent need to protect and restore marine habitats and ecosystems and to reach ambitious eu and global protection and restoration targets by 2030 together with marine protected area mpa managers authorities industries and local communities from 12 demonstration sites and beyond blue connect is codeveloping promoting and demonstrating a systematic approach to marine conservation planning and management this collaborative effort will result in the creation of a powerful blueprint directly supporting 1 setting sciencebased conservation objectives 2 codefining conservation actions for effective mpa comanagement 3 ensuring conservation effectiveness and 4 demonstrating the high potential of these tools for replicability and broader use this will be made possible by establishing a holistic modelling framework that integrates various elements of biodiversity ecological functioning ecosystem services and connectivity while also considering inputs from stakeholders and local communities regarding social economic and cultural aspects when defining mpas and ecological corridors the project will contribute to a more comprehensive sciencebased and inclusive approach to designating new mpas or expanding existing ones transitioning to strict protection restoring ecosystems enhancing ecological connectivity and facilitating mpa comanagement by fostering just and fair stakeholder cooperation and citizen science initiatives blue connect will build a greater feeling of coownership of protected and restored marine ecosystems and mpa networks and empower communities to play a crucial role in safeguarding our seas
deciphering systemic diurnal metabolism and endocrine signaling in heart failure

heart failure hf the ultimate outcome of many cardiovascular pathologies imposes a significant global health and economic burden while remaining associated with high mortality rates there is therefore an urgent need for innovative approaches to comprehensively understand and treat hf most hf research has thus far focused on the pathophysiology of the heart only partially covering the role of noncardiac organs despite hf being a complex multiorgan syndrome the extent to which extracardiac organs particularly those playing a key role in metabolism control contribute to hf remains largely unknown codeheart aims to bridge this knowledge gap by focusing on metabolic interorgan mechanisms of disease our metabolism is temporally coordinated across tissues by the circadian clock system which orchestrates myriad of physiological and metabolic processes my recent work has highlighted the significance of peripheral tissuetissue communication for daily metabolic homeostasis notably my preliminary findings suggest that when the heart is under stress systemic glucose and lipid diurnal metabolism is rewired in this project i will test the hypothesis that the failing heart can alter systemic diurnal metabolic rhythms via the release of specific cardiacsecreted factors to do so i will first determine the impact of hf on systemic metabolic rhythms and on the diurnal transcriptional landscape of liver skeletal muscle and white adipose tissue using specific knockout animal models i will investigate the consequences of systemic metabolic rewiring on cardiac function in hf finally i will pinpoint the metabolic communication network between the heart liver and other metabolic tissues by labelling cardiomyocytespecific secreted proteins and screening their functions in vitro and in vivo in summary codeheart will significantly advance our understanding of the metabolic and molecular adaptation occurring in hf