Dragon09/odtu_chatbot huggingface dataset:
unpacking the black box of orthographic learning identifying the foundational skills underlying efficient reading for english and greekspeaking children

reading is the single most transferable skill taught in the elementary school years it is the foundation for academic learning economic contribution and societal participation decades of research shows that efficient reading relies on precise mental spelling representations of individual words these orthographic representations enable children to recognize words by sight releasing cognitive resources for understanding what they read orthographic learning ol is widely considered the mechanism through which readers build orthographic representations and develop efficient reading and yet its foundational skills have not been established a gap in knowledge that severely limits our ability to teach children the skills they need to achieve efficient reading lexis will identify the foundational skills of ol and in turn efficient reading so that we can develop effective instruction lexis is a largescale crosslanguage longitudinal study following children from preschool through grade 2 through lexis i will establish the foundational skills of ol for both typical and dyslexic readers results for typical readers can be applied to whole classrooms and results for children with dyslexia will be the basis for effective teaching for children with the most intractable reading difficulties i will conduct this study with two distinctive languages english and greek their similarities and differences will ensure that results can be applied across the diversity of european languages lexis takes an interdisciplinary approach bringing together educational psychology special education and psycholinguistics data will be analysed with cuttingedge statistical and computational modeling approaches through lexis i will identify which foundational skills most strongly predict ol and word reading development these identified skills will guide the foci of effective instruction ensuring that all children achieve the strongest possible reading outcomes
sweet adhesins probing bacterial glycoproteins with novel tools to inspire future antibacterial strategies

with bacteria increasingly resistant to current antibiotics new strategies to fight infection are needed bacterial adhesin proteins which play an important role in the establishment of infection appear to be promising targets for novel therapies adhesins enable the first contact between bacteria and host cells we know that some adhesins are modified with highly unique sugars that are important for adhesin stability and adherence however we do not know how widespread this modification is and whether it constitutes a good target for antibacterial strategies a lack of suitable methods for the detection of bacterial adhesin sugars has impeded the detailed study of these sugars blocking further efforts to develop antibacterial strategies against bacterial adhesin sugars in this project i aim to revolutionize our understanding of adhesin sugars in terms of timing and prevalence of the modification which is crucial information to start targeting adhesin sugars to this end i have designed an innovative approach that combines the strengths of carbohydrate chemistry enzymology microbiology and molecular dynamics to 1 establish straightforward methods to selectively visualize and quantify the adhesin sugars directly on the surface of bacterial cells 2 detect the presence of adhesin sugars under changing growth conditions and in relevant clinical isolates and 3 develop a computational method to predict the presence of sugars on adhesins that have not yet been identified recent findings from my team on the process of adhesin modification underscore the uniqueness of adhesin sugars and this experience puts me in an ideal position to start this project the overarching goal of sticky sugars is to lay the foundation for the exploitation of adhesin sugars as antibacterial targets by visualizing adhesin sugars directly on bacteria we can observe their response to antibacterial treatments and pave the way toward clinical applications in the future
european concept for higher altitude operations phase 2 towards the integration between air traffic management and higher altitude operations

the european airspace above fl550 is expected to become an area where operations will significantly expand as a result of increased new entrants presence representing both aviation and space domains with estimated business values in the order of billions of euros per year the european air traffic management atm system including atcs operational procedures and systems needs modernization and adaptation to allow seamless integration of higher altitude operations hao because of vastly different characteristics of vehicles and associated operational safety and performance requirementsecho2 will build on the deliverables of the echo european concept of higher airspace operations project starting from the concept of operations to propose validated solutions paving the way towards the operational integration of hao in atm on three directions space launch real time monitoring module and associated working station for the european atm network manager for increased situational awareness at network level supporting air traffic flow management as well as crisis and contingency management procedural package covering specific ground and airground operational integration issues including for communications navigation and surveillance means associated with the integration of highaltitude platform systems haps operations into atm procedural package covering specific ground and airground operational integration issues including for communications navigation and surveillance means associated with the integration of supersonic hypersonic and suborbital vehicles operations into atmthese solutions will propose all the elements needed by the european atm network operational stakeholders for a rapid harmonized and costeffective implementation of a european approach towards the integration between atm and hao at trl6 maturity they will also include assessments of potential specific related standardization and regulatory activities
renewable energy actions leveraging innovation towards zero emissions in europe

the realize project aims to present a carefully selected and prequalified portfolio of new renewable energy generation technologies to the eu innovation fund if through proposals resulting from successfully completed horizon projects in renewable energy sources res the project will support if project promoters to win major innovation fund support or propose alternative funding opportunities at eu national and local level intense support will be given to ten technology partners in the consortium building on their results from 15 prequalified horizon projects from these we will prepare seven if proposals spanning a variety of sectors concentrated solar power wind solar thermal and solar photovoltaics ocean energy and biofuels as energyproducing installations and as manufacturing projects for small medium and largescale calls their technology will be profiled realize will also reach out to the broader renewable energy community with conferences and written material addressing ifs selection criteria sharing lessons learnt including with innovation funds designers and explaining the complementarity of different public funding programmes deep collaboration with other projects funded under the same call topic is foreseen but not counted upon
under the guidance of mary moriscos and indios against the expansion of the spanish empire and the politics of marian devotion

the focus of my research project is the political implications of marian devotion in the early modern iberian world and its role in the colonial management of native communities of moriscos and indios subdued since the end of the 15th century by the expansion of the spanish empire in this sense my study proposes a political reading of the development of marian devotion in the iberian peninsula and its american colonies analysing how its particular characteristics and evolution reflected the progressive transformation of the spanish imperial project and encoded diverse and changing conceptions of the role of these native communities in the imperial fabric through the comparative study of the representation of indios and moriscos in the collective imagery official documentation and religious literature my research tries to question the role of the virgin and her imagined relationship with these communities in the debate over the ability of native populations to integrate themselves into the colonial regime as faithful subjects and good christians and the place of their culture and religious sensibility in the configuration of the emerging colonial culture through the analysis of the intellectual and artistic products commissioned by christianized morisco and mesoamerican elites my project tries to elucidate how native communities and especially subaltern elites facing the progressive erosion of their rights and privileges used marian devotion to prove the value of their cultural heritage lineage and memory and to reclaim their place in the colonial society similarly my research seeks to understand how native communities transformed the virgin into a political symbol through which they could legitimise their understanding of christianity and o promote an alternative and more inclusive conception of the spanish empire against the growing acculturating and homogenising pressure of the empire and the reformed church
exploring the relationship between climate environment and health in antiquity through the papyri from hellenistic roman and byzantine egypt

reclean aims to study the impact of human activities on the environment of hellenistic roman and byzantine egypt ca iii c bce vii c ce the effects of climate variability and pollution on the health of the inhabitants of egypt and the peoples degree of awareness of environmental issues and their consequences on health research will focus on a body of sources that have not yet been comprehensively analysed the papyri from egypt written in greek and latin which will be integrated with literary and historical sources archaeological finds and inscriptions and with the results of studies based on palaeoclimate proxies and palaeopathological samples the outgoing phase of reclean years 1 and 2 will take place at the departement altertumswissenschaften of the university of basel which hosts the basel climate change and ancient history lab an interdisciplinary initiative dedicated to the study of ancient environmental issues here the fellow will receive specific training in environmental history of antiquity essential for the pursuit of the projects objectives in a vibrant and multidisciplinary environment that brings together specialists in the humanities and in the environmental sciences the return phase year 3 will take place at the dipartimento di studi umanistici e del patrimonio culturale of the university of udine where the fellow will consolidate her preparation in papyrology and further delve into the subject of environmental awareness in antiquity the results of reclean will be made available to the scientific community through open access publications and presentations at conferences while the communication activities will reach a wider audience with the aim of stimulating a reflection and debate on environmental issues in a historical perspective thus contributing to raising awareness of the magnitude that environmental problems have reached today when compared to the past and the need for urgent intervention
atomically dispersed heterobimetallic catalysts for cooperative ch bonds activation

the central objective of the duo project is the development of original welldefined and highly dispersed heterobimetallic supported catalysts using a molecular approach its chemical foundation is to take advantage of both 1 metalmetal cooperative effects and 2 siteisolation benefits in combination to achieve unprecedented and highly reactive active sites this will ultimately lead to new bond activation pathways to tackle challenging catalytic transformations specifically i target supported earlylate pairsite catalysts which are ideally suited to promote the heterolytic cleavage of strong ch bonds i will take advantage of this unusual reactivity in two classes of catalytic applications i the latestage isotopic labelling of organic substrates such as active pharmaceutical ingredients and ii ch4 and light alkanes valorization into higher hydrocarbons under nonoxidative conditions these catalytic targets are not only scientifically demanding from a fundamental perspective but also possess high potential industrial outcomes a leap forward with respect to todays state of the art is required to achieve these goals i propose to use an interdisciplinary approach at the forefront of current knowledge combining the benefits of innovative and tailored molecular chemistry with those of surface science and heterogeneous catalysis i have recently pioneered breakthrough concepts in this hot emerging research area which are a strong guarantee for the success of the duo project
novel userfriendly ultrasound methods for monitoring and prevention of cerebral hypoxia

a lack of oxygen in the human brain cerebral hypoxia can result in permanent neuronal damage cerebral hypoxia is prevalent in half of all critical ill patients but poor health impedes research in the intensive care unit highaltitude exposure 2500 m is associated with a lower pressure of oxygen and offers a unique setting to investigate hypoxiadriven changes in otherwise healthy individuals unfortunately at present noninvasive methods to quantify surrogates of cerebral hypoxia are either laborious and require highskilled personnel or have large interintraobserver variability and no clear cutoff values a userfriendly unambiguous and accessible diagnostic tool is urgently needed for the monitoring and decisionmaking in the field and at the beside uschimp ultrasound cerebral hypoxia imaging for monitoring and prevention aims to provide a proofofconcept by combining volumetric us to measure optic nerve sheath diameter as a surrogate of intracranial pressure with wave intensity analysis from the internal carotid and vertebral artery as a surrogate of changes in cerebral oxygen delivery in three work packages uschimp builds the theoretical groundwork through simulation wp1wp2 and the first practical proofofconcept through translation in an experimental study wp3 in which human volunteers are exposed to mild hypobaric hypoxia wp3 is performed in the terraxcube an extraordinary environmental chamber of the institute of mountain emergency medicine at eurac research uschimp will provide accurate information about key clinical syndromes the data is directly relevant to the management of conditions related to highaltitude hypoxia besides many clinical conditions such as intracranial haemorrhage brain injury and stroke present with elevated intracanal pressures and altered cerebral haemodynamics their management will be supported by an accessible and reliable noninvasive bedside monitoring that uschimp aims to provide
describing the role of the epsteinbarr virus and s1pr inhibition in the pathogenesis of multiple sclerosis

multiple sclerosis ms is a demyelinating disease of the central nervous system cns one million people in europe have ms experiencing a significantly reduced quality of life and dying 714 years younger than average the annual burden on european economies is 35b epsteinbarr virus ebv infects almost all europeans and is aetiologically linked to ms with infection increasing disease risk 32fold despite the huge personal societal and economic impacts of ms the underlying role of ebv in its development remains poorly understooddreams will explore how ebv contributes to ms development to do this the postdoctoral fellow pf will utilise a novel humanised mouse model which harbours the major genetic risk factor for ms and is permissive for ebv infection this model displays characteristics common with human ms including cns immune cell infiltration applying multiplex immunofluorescence the pf will explore the nature of this immune infiltrate and how it is influenced by drugs used to treat ms focussing on inhibitors of s1pr signalling combined with mechanistic in vitro studies to determine how these drugs interact with ebvinfected bcells and ebvspecific tcells this work will allow new insights into how s1pr modulation affects ms immunopathology as such this research aligns with the horizon europe health cluster and several un sustainable goals and meets open science gender equality supervision and green charter guidelinesthe pf will receive training in humanised mouse models in vivo imaging and flow cytometry during an outgoing 24month phase at the university of zurich switzerland this will be followed by a 12month return phase at the university of limerick ireland learning in vitro tcell assays the pf will leverage the interdisciplinary supervisory team to meet the research training objectives outlined in preparation for an independent research career in the field of virusassociated diseases
safe and efficient marine transportation of liquid hydrogen

the overall goal of lh2craft is to develop next generation sustainable commercially attractive and safe longterm storage and longdistance transportation of liquid hydrogen lh2 for commercial vessels or even as fuel in certain applications it aims at developing an innovative containment system of membranetype for highcapacity storage eg 200000 m3 at a temperature of 253 deg c and demonstrating and validating it on a 10 ton 180 m3 prototype it foresees the analysis of alternative conceptual designs with safety and risk assessment initiated at an early stage of the design process of the cargo containment system ccs exceeding currently demonstrated sizes the design will allow lh2 storage to large dimensions similar to those of existing lng carriers special characteristics storage tank handling distribution safety and monitoring subsystems hdmss of the concepts that support up or downscaling will be detailed in order to prove the modularity and scalability of the proposed solution the ccs will achieve aip and general approval by a major classification society three iacs members are participating demonstration will be done via the detailed design construction and testing of the reduced size prototype lh2craft will also develop a preliminary integrated ship design and carry out the corresponding cost estimation achieving reduced boiloff rates of 05 per day a life cycle model will provide a significant tool enabling comparison between different new design or retrofit strategies while the lca of the large carrier will evaluate the environmental impact from cradle to grave identifying also activities related to sustainability and recyclability and determining the environmental benefits two societal objectives will be served societys needs and eus strong global maritime leadership for its innovationdriven industry providing highly skilled jobs efficient technological solutions and international regulatory standards
living with drought human environment relationships in drying european landscapes

recent multiyear droughts have led to severe and unequally distributed socioenvironmental disruptions across europe the earths fastest warming continent much more than shortterm crisisevents droughts pose longterm multifaceted cultural political and conceptual challenges to society that remain poorly understood adopting a comparative multisited anthropological approach this project will generate needed insights into how peoplefarmers conservationists politicians foresters scientistsand local communities learn to live with drought in humandominated landscapes in spain germany and norwaycombining stateoftheart theoretical approaches from such varied disciplines as anthropology geosciences and the environmental humanities drought seeks to meet three specific objectives 1 to produce a novel integrative cultural theory of drought as an inherently relational and situated sociocultural and geophysical process that unfolds in and through humandominated landscapes 2 to complete the first historically informed indepth ethnography of living with drought in europe and 3 to experiment with collaborative sensory and morethanhuman research methods as a way to explore the affective experiential and material manifestations of droughtfulfilling these objectives will enable drought to achieve its overarching aim to generate an empiricallydriven theoretically ambitious field of scholarshipanthropogenic drought studiesthat will advance knowledge of droughts in the social and cultural fields while adding needed empirical depth and nuance to emerging sciencecentred discourses on droughts in the anthropocene the knowledge produced will help transform academic public and political understanding of and debates over what constitutes droughts why they matter and how we should respond to them
human ecmbased platform for anticancer drug testing cares cancer drug testing

with 2 million cancerrelated deaths and an annual cost of 100 billion cancer constitutes a major european challenge cancertreatments have considerably improved over the last decades however the success rate of new anticancer drugs in clinical trialsremains frustratingly low limiting the opportunities for fast and accurate development of innovative targeted cancer therapies ourvision is to provide a bold and innovative technology that recapitulates the active part played by the human tumourmicroenvironment which has crucial roles in regulating tumour initiation propagation and progression through the dynamiccrosstalk between the tumour cells and the extracellular matrix cares combines leading academic and nonacademic experts in thefields of matrix biology biomaterials microfluidics and cancer research to establish an accurate tool to assess cancer cell responses toa variety of anticancer drugs as a proofofconcept we will use breast cancer cells as a model system with the perspective ofextending the system to other cancers our final goal is to deliver a novel and userfriendly platform that by resembling the humantumour microenvironment in early and advanced cancer stages can predict with unprecedented accuracy the response of tumourcells to anticancer therapies in vivo this will facilitate development and testing of new drugs and narrow the gap betweentranslational cancer research and targeted cancer treatment with a significant impact on society and the economy the ambitiousscientific goal will provide the background for intense transsectoral and interdisciplinary training of young scientists who will beprovided with an excellent translational research portfolio allowing them to succeed both in academia and industry
eu sdgdriven innovation ecosystems stimulating economic growth and addressing innovation support imbalances in europe and beyond

the goal of this proposal is to build the capacity to cocreate and foster an inclusive eu sdg driven innovation ecosystem focused on the greatest social economic and environmental needs of our time thereby contributing to the realization of the green and digital transition of europe its aim is to provide capacitybuilding activities to enable the establishment of sdgsdriven innovation ecosystems across italy france portugal cee and israel we will foster the existing crosssector collaboration within the nabs and gsg between the private investors comports startups smes public governments eu agencies development banks academia research knowledge rd and social ngos philanthropy social enterprises actors as a means to plan the establishment of an interconnected and sustainable ecosystem by delivering new research and data facilitating knowledge exchange creating new collaboration and engagement opportunities within existing networks and beyond