Dragon09/odtu_chatbot huggingface dataset:
systematic study of igg4autoimmune diseases to develop new treatment strategies

igg4autoimmune diseases igg4aid are rare but collectively correspond to a significant group of devastating diseases affectingmany different organs eg skin brain nerves and kidney in patients that often remain unresponsive to current treatments igg4aidhave commonalities indicating a shared underlying immunopathogenesis that make a joint approach to identify new therapeutictargets and test new treatment strategies feasible and necessary we hypothesize that genetic risk factors and a dysregulatedimmune response may lead to an increased susceptibility to produce antibodies targeting selfproteins these are of a specialsubclass called igg4 which are usually harmless but can cause disease in these patients by interfering with normal functions in thebody we are the first consortium that aims to study igg4aid comparatively including pathogenic igg4 and the cells molecules andmechanisms involved in igg4 autoantibody production using an explorative multiomics approaches in combination with stateoftheart cell and molecular biology methodology we will establish a new humanized mouse model of igg4aid for the developmentand testing of a novel immuneapheresis based therapy aimed as immediate relief therapy for all igg4aid patients our innovativetraining program combines universitybased and multidisciplinary researchbased training with stateof the art webbased trainingand inperson trainings by the academic and nonacademic sector we aim to foster a new generation of experts in igg4aid that are1 are highly employable both in the academic and industry sectors and qualified for innovative multidisciplinary translationalresearch with a focus on biomedical product development and 2 equipped with the skillsets for digitalization awareness for genderequality and diversity and competent in sustainable research and innovation approaches to address current and future challengessuch as climate change social inequalities and pandemics
innovative career development programme that enables 50 talented international researchers to work on industrially focused sustainability research projects

sustainfit is an innovative msca cofund programme providing international mobility by funding and implementing 50 threeyear incoming fellowships to the republic of ireland in the area of industrially focused sustainability research sustainfit will be run by enterprise ireland the national innovation agency and the fellows will have the option to be hosted at any of the irish higher education institutions and public research organisationsthe sustainfit research and innovation focus is on the european green deal eight policy pillars clean energy sustainable industry building and renovating sustainable mobility biodiversity sustainable food systems eliminating pollution and climate neutrality digitalisation projects that benefit green deal objectives are also supported in line with the declaration on a green and digital transformation of the eu implementation of the programme includes an extensive promotion of recruitment calls to an open meritbased competition for the applying researchers founded on equality of opportunities and best practices in international peer review applicants will have the freedom to choose their host research organisation hro and secondment enterprise and to define their own research training project recruited fellows will be supported with a dedicated programme management arrangement that has access to the full range of enterprise ireland professional supports and hro supports in a structured career development framework that includes a mandatory 612 month intersectoral secondment highquality supervisory support from the hros and enterprise secondment partners access to disciplinespecific training and structured transferable skills training and personal career development support sustainfit will develop a new cadre of researchers who can move seamlessly to industry in europe bringing high levels of research expertise in an area of high priority industrially focused sustainable research
protein ruler to create affordable biosensor diagnosis for the many

ovarian cancer is the most common malignancy of the female reproductive system worldwide and the leading cause of death fromgynecological cancer however if diagnosed during the early stages patients have a good prognosis at around 90 5year survivalrate despite its lethality there are currently no effective simple tests for diagnosis nor populationbased screening techniques forovarian cancer emerging tests detecting cancer biomarkers have the potential for greatest impact for surveillance and earlydetection such as the fda approved ca125 and he4 biomarkers importantly because the levels of these biomarkers are not thesame among all healthy females and increase with age these tests should be quantitative current quantitative diagnostic tests forca125 and he4 detection are expensive require highcost infrastructures and trained professionals therefore there is an urgentneed for developing cheap reliable easytouse quantitative tests for ovarian cancer biomarkers in this project groundbreaking innovating research will give rise to novel technology enabling the detection of cancer biomarkers in a manner that is quantitative and yetsimple portable and cheap
from paradise to mass extinction correlating and comparing low and high latitude basins during the greatest permian extinction events and subsequent faunal recoveries

drastic global climate change during the permian resulted in two of the greatest mass extinction events of all time one around 260 ma ago and the other around 252 ma ago arguably the best record of these events on land is preserved in the main karoo basin mkb of south africa which was situated in higher latitudes 60 s at those times because of the relatively poorer fossil record from lower 015 palaeolatitudes latitudinal differences in faunal assemblages and lack of precise radiometric dates global applicability of extinction and faunal recovery patterns observed in the mkb has long remained elusive we simply lacked the necessary data as such stratigraphic correlations between basins are tenuous moreover it is not known whether the terrestrial expression of the two greatest mass extinction events of the permian and subsequent ecosystem recovery are preserved in western europe extinctrecov is a novel interdisciplinary project that aims to for the first time combine palaeontological sedimentological stratigraphical and geochronological data to correlate the permiantriassic spanish and french basins and the mkb extinctrecov will also explore patterns of faunal turnover extinction and recovery during the midtolate permian and across the permotriassic boundary ie between 265 and 250 ma ago the proposed project draws on the geological geochronological and palaeontological advances and work undertaken during the past two decades in the pyrenees and lodve basins spain and france and the main karoo basin south africa which finally makes this ambitious project possible implications of the results from the proposed project include new and key insights on the faunal communities present in this part of pangea and a better understanding of how terrestrial ecosystems were affected by and recovered from the late capitanian and permotriassic extinction
international dimensions and effects of populism

the doctoral training network ideopop international dimensions and effects of populism aims to study how the phenomenon of populism is related to world politics while the global rise of populist political parties governments and movements all over the world from hungary to india from italy to mexico from turkey to el salvador has led to a great interest in the domestic implications of populism its international effects have remained understudied but populism impacts the foreign policy of single countries as well as international politics more broadly understood and it is indeed frequently mentioned as one of the main causes for the crisis of the socalled liberal world order the doctoral network ideopop will consolidate the study of the international dimensions of populism as a research programme shaping a new generation of scholars and developing policyrelevant insights on how to address the consequences of populism internationally the focus will be on the ideational institutional diplomatic and communicative international dimensions of populism these will be addressed in four distinct work packages the proposed doctoral network is driven by the following overarching research question how are domestic and international politics related in populism and how does populism impact international politics as the phenomenon of populism is likely to continue affecting citizens lives state institutions regional integration efforts and the liberal international order in the years to come a better understanding of its international implications is of utmost importance under the guidance of some of the leading scholars in this area a new generation of doctoral researchers will be trained in the study of the international dimensions and effects of populism and will contribute to the networks efforts at jointly addressing the overarching research question
towards faster superresolution dna optical mapping using plasmonenhanced fluorescence

human microbiome science is advancing showing promise of having important impacts on human health with new insights into disease etiology and general human biology accordingly dna sequencing platforms have been developed rapidly expanding the scope in microbiome research among others optical mapping technique capable of imaging single dna molecules provides access to genetic information on single molecules up to 1 mbp in length it uses fluorescence imaging of linearly stretched dna molecules labelled at specific sites to probe information patterns along the molecules the precision of the method is further improved by resolving single molecules below the diffraction limit through superresolution imaging however requirement of large photon budget slows down the speed of imaging as long acquisitions are required to build up sufficient photons for precise localization this affects the throughput of dna optical mapping which involves imaging large areas thereby limiting its capabilities in providing realtime information of the microbiome on daily basis enhancing the emission rates from single molecules can overcome this limitation to permit faster image acquisition here we propose to use plasmonenhanced fluorescence by employing substrate made out of wetchemically synthesized gold nanotriangles for optical mapping of human gut microbiome plasmonic nanostructures can confine incident electromagnetic field into small area near their surface leading to strong light absorption and higher emission rates from fluorophores in their vicinity the use of wetchemical plasmonic substrate exhibiting strong plasmon resonance can significantly increase the number of photons released from the labelled dna allowing faster image acquisition with the improved speed the time required for optical mapping analysis can be significantly shortened enabling longitudinal metagenomic analysis with practical implications for quicker diagnosis and personalized health care
theatre healing and epiphany in the ancient mediterranean

concepts of medicine health and healing are now at the core of the global agenda due to the recent pandemic in this context a better understanding of the intangible cultural heritage of ancient and indigenous medical cultures is crucial it is often assumed that contemporary european culture derives from the ancient grecoroman one but if we turn to core values such as health and healing we find out that in grecoroman antiquity they are much more comparable to many contemporary nonoccidental cultures than to the western biomedical paradigm dreams and visions were strongly connected to these concepts as they were used in the ritual of incubation which brought devotees into visionary contact with the invisible to obtain healing or prophecies incubation was the distinctive feature of the cult of asklepios the greek god of medicine theam explores the relationship among dramatic performance healing and epiphany by contextualising such practices within the cultures of ancient mediterranean how did rituallyinduced epiphanies spread in the mediterranean as a tool for healing what agency did thousands of unknown worshippers have in the dissemination of these ritual gestures how are these ritual practices embedded in the design of sanctuaries and theatres what was the role of islands in this historical phenomenon how do this ancient practices relate to nowadays concepts of healing and health the case studies are the island sanctuaries of asklepios in sicily the cyclades and creteultimately theam represents a valuable contribution to our understanding of ancient religious practices their evolution and their socioeconomic implications it offers a platform for innovative medical approaches that harness the power of performance as a therapeutic tool such as psychodrama and psychotheatre further enriching our comprehension of the intersections between ancient religion medicine and society
dissecting the contextspecificity of genetic immune regulation in plasmacytoid dendritic cells

antiviral immunity and autoimmune diseases exhibit high interindividual variability despite intensive research the genetic and molecular basis of this variability is incompletely understood a key player of the immune system is the plasmacytoid dendritic cellpdc recent singlecell work revealed functionally distinct pdc subsets considering that pdcs respond to many pathogens this highlights a previously underappreciated functional diversity of pdcsi hypothesize that the genetic regulation of pdcs plays a fundamental role in explaining antiviral response and autoimmune variability based on my previous work on immune cells this genetic regulation is expected to be highly contextspecific depending on cell type cell response ancestry populations and sex among other factorsthe overarching goal of this proposal is to elucidate the contextspecificity of immune response and its genetic regulation in pdcs to improve our understanding of human antiviral response variation and pinpoint undiscovered disease pathways of autoimmune diseasesto this end i will generate populationscale linked scatac sc3rna and sclongread cdnaseq data of baseline and tlr7stimulated pdcs from healthy individuals across three ancestry populations i will identify novel pdc subtypes and their immuneregulatory circuits by integrated multiome analyses molecular quantitative trait lociqtls and their degree of contextspecificity will be used to build prediction models of genetically determined immune responsiveness and decode autoimmune disease loci to develop mechanistically anchored interventions for precision medicineimmgendc will gain fundamental insights into the variability of antiviral immune response that will enable the development of new treatments as exemplified by the current pandemic importantly immgendc will also identify genetic determinants of immune variability across diverse ancestry populations thus paving the way for equitable access to medicine
capture and reuse of biogenic gases for negativeemission sustainable biofuels

cronus aims to accelerate on the path to sustainable bioenergy and play an important and constructive role in achieving the un sdgs by incorporating in the biofuels value chain carbon capture utilisation and storage cus techniques promoting the decarbonisation of the eu economy in accordance to european green deal goals a wide spectrum of biogenic gases cus technologies enzymatic capture of co2 autotrophic algae cultivation biological co2 hydrogenation syngas biomethanation insitu biomethanation biogenic carbon storage by biochar production and soil application will be validated in labscale trl4 the proposed technologies will be upscaled to 5 functional prototypes that will operate in relevant environments of biofuels production plants trl5 evaluation of the technical economic environmental and social sustainability of the project solutions and services will be performed by exploitation of the latest uptodate tools with special emphasis on the sustainability and circularity of the project a roadmap to market the technologies and services with a strategy to address market segmentation penetration barriers and opportunities will be drawn public and scientific awareness of the project will be raised and all relevant stakeholders will be actively involved in the codesign codevelopment and coimplementation of the possible pathways for biogenic effluent gases capture and utilization within the biofuels value chain cronus impactful exploitation plan will facilitate the strategic planning of netnegative biofuel production supply chains considering the integration of cronus technologies and the results of the sustainability assessment emphasizing the co2 footprint costefficiency and scalability
integrated research infrastructure services for climate change risks

adaptation to climate change requires indepth understanding of climate change driven risks including their determinants hazards exposure and vulnerabilities and impacts to human production and natural systems integrated research infrastructure services for climate change risks iriscc is a consortium of diverse and complementary leading research infrastructures ris covering disciplines from natural sciences to social sciences across different domains and sectors iriscc provides scientific and knowledge services to foster cuttingedge research and evidencebased policymaking to improve europes resilience to climate change iriscc ensures a onestopshop for various user communities on climate change risk related ri services by setting up a dedicated catalogue of services and related access management system both for granting transnational onsite and remote and offering virtual access the catalogue of services will be built through three consecutive releases each delivering increasingly integrated services to its user communities the iriscc service integration will include service design labs employing codesign and transdisciplinary action and service demonstrators benchmarking the integrated crossri services in addition to services aimed towards the scientific community iriscc will offer knowledge services aimed towards policymakers and other stakeholders this is done together with risk management platforms the research enabled by iriscc contributes to future reports on climate change effects ipcc ipbes as well as policy and decisionmaking to meet the targets of climate adaptation strategies iriscc contributes to training a new generation of scientists to efficiently use ri services and for data stewardship data from iriscc will be open and made available in compliance with fair principles and linked to european initiatives such as eosc strong links will be created between iriscc and current and future efforts under horizon europe
breakthrough a glycyl radical enzyme long range activation mechanism

glycyl radical enzymes gres are one of the most prominent biological catalysts in both strict and facultative anaerobes they are responsible for a broad range of radicalbased chemistry and catalyse reactions involved in diverse metabolic pathways such as acid fermentation dna synthesis and the anaerobic metabolism of pollutants gres are activated by members of the sadenosylmethionine sam radical family activation of gres requires the formation of a proteinprotein activation complex with the small greae all known structures of gres show that a major conformational change very likely occurs during the glycyl radical generation upon interaction with the greae only a structure of a greae holocomplex would shed light on the unprecedented conformational changes involved in gre activation glycyl radicals and ironsulfur clusters are extremely oxygen sensitive rendering the proteins challenging to work withgream will narrow a significant knowledge gap by studying the anaerobic class iii rnr natural fusion nrddnrdg in order to study the mechanism of activation gream will use an integrative research approach combining biochemical biophysical and cryoem assisted by xray crystallographywith my experience in anaerobic protein characterisation and crystallisation i will join the fontecave lab to build up on their experience in spectroscopic characterisation of oxygensensitive protein complexes and achieve the first aim or gream during a secondment in the logan lab who are expert in structural characterisation of arnrs and have a long lasting collaboration with the host i will solve the anaerobic cryoem structure of the nrddnrdg holocomplex and achieve the final goal of gream this newly established international collaboration will permit combining integrative approaches to successfully answer all greams questions and allow me to acquire invaluable experience in my future career
the role of social economy in addressing social exclusion providing quality jobs and greater sustainability

with a growing aging population the eu faces increased demand for quality social elderly care however intricate legal and policy landscapes for social economy organizations ses contribute to poor working conditions gender bias and innovation challenges hindering the provision of sustainable and inclusive social services by ses this is particularly exacerbated in rural areas where access to facilities and technology deployment and logistics is complicated the eu context is facing the urgent need for affordable services and to rethink the dominant recipient model of social care which challenges the sense of dignity identity and quality of life of both elderly people and care givers sonya emerges as a pioneering initiative to assess the role of ses in retaining and attracting social elderly care workers to foster social innovation effectiveness in rural areas our vision seeks to scale up ses successful activities beyond tool support services and methods development by empowering ses to develop participatory multiactor networks and social and environmental community initiatives identifying and transferring social innovations for inclusive employment and better working conditions while measuring impact with scientific precision for improving legal and policy frameworks supporting ses sonya is implemented by a consortium of scientific partners with expertise in operationalising multiactor participatory models sustainability assessment workers rights and effective representation and policy making enabling entities representing 3 eu ses models varying in size network development and national context and support actors sonya will facilitate a transition towards more respected inclusive and valued social elderly care services beyond medical care targeted ses will be able to efficiently create quality jobs contribute to equal opportunities and socioeconomic inclusion of disadvantaged groups and help revitalise eus rural and depopulated areas