Dragon09/odtu_chatbot huggingface dataset:
gender and diversity index for a fair competitive resilient and sustainable europe

the gendex mission consists of the development of the pilot innovation gender and diversity index providing consistent information currently missing or fragmented to startups scaleups corporates the eic other investors and funding bodies market actors and policy makers across europe the overall aim is to improve the availability of all talent particularly female talent to the eic portfolio of projects and companies and the eu innovation ecosystem for the first time ever a gd index will be elaborated including a wide range of indicators related to gender but also to diversity factors covering all european member states plus the uk gendex will review the existing baseline and access a high number of data sources but it will bring a unique value by carrying out additional primary research both at quantitative and qualitative levels data sets will be assessed gaps will be identified a more standardbased approach to data will be suggested all resulting in a richer definition of indicators and hence a gd index that will become a reference in europe supporting evidencebased decisionmaking a full report on the index will be released with complementary material including a webbased interactive dashboard that will enable smart data visualizations and a widget that will be used for company selfassessment and as a potential data collection tool a wide dissemination communication and awareness campaign will be implemented to ensure engagement and maximize the adoption of the gd index the gendex consortium comprises a complementary set of recognized partners that includes idc european women in vc and bluspecs authors of some of the key works in the field and also a guarantee of the best possible networks for stakeholder engagement such engagement will ultimately lead to maximization of the use of the gd index and hence of its impact gendex will also run a 2phase validation with an experts group composed of at least 18 senior leaders
the development of biosupported homogeneous organocatalysts with improved recycling potential through sequential de and repolymerization and their use in co2 valorization catalysis

the use of homogeneous catalysis is currently limited as they lack the ability to be easily recycled and thermal deactivation of the catalyst cannot be always avoided these features present important hurdles for the application of homogeneous catalysts in commercial processes and represents an open challenging designing ways to bridge the advantages properties of homogeneous and heterogeneous catalysis through the creation of supported homogeneous catalysts with welldefined active sites having high stability and recycling potential creates new incentives for circular type homogeneous catalysts with application potential in synthetic chemistry in this project several approaches are presented to realize this challenging goal first wellknown nheterocyclic bases such as tbd and dbu will be immobilized onto a biobased polycarbonate and their activity optimized in the synthesis of glycidol carbonate by a sequential catalyst testingdepolymerizationrepolymerization approach the depolymerization will be facilitated by a base catalyst while the repolymerization will be carried out through a known procedure developed at the host laboratory this allows to optimize and finetune the catalyst structure in terms of active site separation concentration and local microenvironment in order to be able to extend the recycling of the catalyst components to a fully recyclable system a crosslinked version will be created and tested during an industrial secondment a second strategy builds on a controlled copolymerization of prefunctionalized biobased monomers that feature two separate catalyst components their successful copolymerization and variation of their relative ratio permits the optimization of the catalytic activity of this binary system in co2 valorization through a similar catalyst testingdepolymerizationrepolymerization sequence and ultimately to a generic process that allows to recycle a homogeneous catalyst through a unique approach
development of heating technologies for the efficient renewable energy consumption of co2neutral downstreamprocesses

the aim of eeco downstream is to enable a clean steel production by developing advanced and breakthrough technologies for the steel making downstream processes this will decisively support the eu in achieving its goal towards climate neutrality by 2050eeco downstream focuses on the efficient utilization of hydrogen biogas and electricity to substitute carbonbased fuels and drastically lower the carbon footprint of the steel production energy efficiency is pursued to enable sustainable utilization of volatile green energy currently installed burners of reheating furnaces will be enabled to utilize green h2 by integration of newly designed and 3dprinted burner components instead of replacing entire burner systems to increase fuel flexibility hybrid heating concepts h2 and electricity will be investigated in a pilot walking beam furnace since the mentioned solutions will change the waste heat streams and their heat recovery in future downstream processes must be reevaluated this will be done by analysing the partners processes and plants development and testing of waste heat recovery concepts and recuperators regarding their suitability to new fuels and their off gases while considering their impact on materialsproduct energy efficiency potentials of downstream processes will be evaluated by case studies for the application of hot charge from casting to hot rolling by covering of the slabs with passive and active panelsthe elaborated solutions will be assessed by technoecoenvironmental analysis to evaluate their applicability and to increase their acceptance in the steel communitythe eeco downstream consortium has a deep and shared knowledge of iron and steel making downstream processes and heating technology materials engineering numerical simulation experimental investigations economy and life cycle analysis
hunting dormant black holes in the galaxy with sdssv

stellar evolution models suggest that there ought to be 10e7 stellarmass black holes bhs in our milky way however we currently know only of 20 bhs and those are in binaries where accretion makes them shine in xrays beyond that no nonaccreting dormant bh has ever been robustly identified across the galactic disk finding dormant bhs in binaries dbhbs is fundamental to learning when which bhs form how massive stars die and what the precursors of bh gravitational wave events are such bhs cause characteristic time variations in radial velocity rv flux and lightcentroid positioning of their luminous companion providing an avenue for detection and study spectroscopic astrometric and photometric surveys now yield the data needed to search for dbhbs yet recent dbhb candidates have instead turned out to be shortlived evolutionary phases of close binary stars thus any successful search for dbhbs must entail sifting through vast samples using a combination of these signatures and rigorously eliminating false positives i propose an unprecedented search for galactic dbhbs that should find 100 of them drawing crucially on the spectra of 580000 massive stars from the sdssv survey as sdssv project scientist i have helped shape it as the only allsky multiepoch spectroscopic survey systematically focused on stellar physics novel analysis of these spectra will be meshed with detailed modeling of tess light curves and gaia astrometry through guaranteedtime highresolution followup spectroscopy on the candidates we will get detailed rv curves and crucial spectroscopic disentangling to identify false positives that have two luminous components either dbhbs do not exist in any numbers in our galaxy or this proposal will find and characterize them beyond the risky search for dbhbs this program will break ground in identifying numerous other dark companions to massive stars such as white dwarfs or neutron stars
speciesspecific aspects in eukaryotic mrna translation modulation and their implications in diseases

mrna translation is a universally conserved process consisting on translating the genetic code into proteins the primary building blocks of all living organisms translation is mainly operated by the ribosome a hybrid molecule made of rnas and proteins in most eukaryotes at least two types of mrna translation coexist in nearly all cells indeed although the quasi totality of the proteins is translated in the cytosol by the cytosolic ribosome a small yet essential fraction of mrna translation can take place in the mitochondria the cells power plant while mitochondrial translation process has proven to be substantially speciesspecific numerous speciesspecific structural and regulatory differences also exist in the cytosolic translation process in spite of their relative conservation among eukaryotic species and are yet to be elucidated we will use various structural and molecular biology methods to investigate from a diseaserelated perspective several speciesspecific aspects of mrna translation modulation in mammals and in pathogenic parasites from the family of kinetoplastids namely 1 we will investigate the molecular roles of several kinetoplastidspecific proteins involved in translation and evaluate their validity as pharmacophores 2 we will study mitochondrial translation in kinetoplastids and focus on its variable regulation in different forms of the parasites during their lifecycle blood vs insect stages 3 we will study cytosolic mrna scanning for the startcodon during translation initiation to i understand its molecular basis in different types of mrnas native and modified mrnas natural or artificial ii and investigate its alteration in colorectal cancer caused by the absence of a ribosomal rna modification results will advance our knowledge of speciesspecific mrna translation and open new perspectives for developing treatments against various human diseases and infections antiparasites cancer therapy mrna vaccines
breakthrough fuel cell technologies for aviation

the proton exchange membrane fuel cell technology emerging from the automotive industry is of high interest for the future aeronautic industry while automotive industry fuel cell fc systems are usually limited to 100 kw aircraft require a significantly greater amount of power multimw and must operate at both different temperatures and pressures while keeping the systems safety and reliability levels to aeronautical standardsbrava will develop breakthrough technologies for a fcbased power generation system pgs for aviation the overall target is a highperformance pgs with a power range of over 2 mw the foreseen future multimw system will be a multistack aircraft propulsion system airbus reckons that several of such multimw fcbased pgss can be used to propel an aircraft capable of carrying up to 100 passengers on distances of up to 1000 nautical miles advances in the fc stack and balance of plant components the thermal management system heat exchanger design and technology and air supply system architecture will act as building blocks for this multimw fcbased pgs the key project results arenew catalysts and membranes with higher performance durability and higher operating temperature capability to enable integration into new membrane electrode assemblies to reach high efficiency low weight compactness and long lifetime 2phase cooling based thermal management system including a newly designed fuel cell stack for compactness weight reduction and hence improved fuel consumptionadditive manufactured heat exchangers for increased heat rejection compactness lightweight and low draga new air supply architecture and components designed and optimized to provide low parasitic power and weight reduction and thus enabling lower fuel consumption and equipment costeach of the breakthrough technologies for these fc system subsystems will be advanced to trl5 ie technology validated in relevant environment
descending control of motor circuits in drosophila

understanding how neural circuits control arm and leg movements is a major challenge in neuroscience with implications for treating movement disorders designing neural prostheses and robotics limb movements are coordinated by lowlevel motor circuits in the spinal cord in vertebrates or ventral nerve cord in invertebrates which receive movement instructions from the brain via a small number of descending neurons dns dns constitute the critical link between the brain and the body however despite their importance little is known about how specific dns are recruited depending on the behavioral context and how lowlevel motor circuits in the spinal cord or ventral nerve cord translate dn activity into limb movement i propose leveraging cuttingedge tools to tackle these fundamental questions in the compact nervous system of the fruit fly drosophila melanogaster the flys neural circuits for controlling limbs are more tractable and experimentally accessible than those of vertebrates but still similar in their organization and function focussing on dns that have been implicated in the control of walking speed i will characterize the activity of dns during behavior identify the target neurons of dns in motor circuits in the ventral nerve cord and quantify the influence of dns on these target neurons by combining intracellular patchclamp recordings calcium imaging and movement tracking in behaving animals with computational modeling and connectomics the proposed research project will provide unique mechanistic insight into the interactions between the brain and lowlevel motor circuits that have remained elusive in other animals
brainwide processing and wholebody biophysics of directional sound

locating sound sources such as prey or predators is critical for survival in many vertebrates terrestrial vertebrates achieve this by measuring the time delay and amplitude difference of sound waves arriving on each ear for fish however the faster speed of sound in water and the proximity of the two ears make such cues useless yet directional hearing has been confirmed behaviorally and the mechanisms have puzzled researchers for decades theoretical studies attempted to explain this remarkable ability proposing that acoustic pressure and particle velocity signals must be measured separately and then be compared however the locus of this computation is unknown and its neuronal and biophysical mechanisms remain obscure this is because most vertebrate brains and inner ears are highly opaque rendering them inaccessible to systemic optical investigation addressing this challenge we recently identified the teleost danionella translucida dt as a unique vertebrate model for neuroscience dt are among the smallest living vertebrates and are transparent throughout their lifespan despite having the smallest known vertebrate brain they display a rich set of complex behaviors including acoustic communication illustrating the ethological relevance of hearing for this species building on our experience with acoustics and brainwide imaging we will exploit this model to 1 image the vibrational response of the inner ear 2 study the neuronal activity of the sensory epithelia and 3 follow the neuronal integration of sensory signals by circuits across the brain with functional imaging these measurements will for the first time allow us to study the entire acoustic processing chain from acoustic stimulus via mechanical transmission to brainwide neuronal integration at single cell resolution if successful they will constitute a major step for our understanding of hearing mechanisms in fish and illuminate the evolutionary origin of vertebrate audition
sns collaborative operations and output optimisation

the sns coop project is devoted to supporting and facilitating the activities of the sns initiative under the smart networks and services joint undertaking sns ju the sns coop project will achieve this by orchestrating and organising strategic activities in collaboration with the sns ju office and the 6g industry association to capture and promote the european industry view on 6g the achievements of the 6g sns initiative and projects and to promote the ambitions of the sns ju the sns coop project will build on the strengths and assets of the platforms and communities established through the sns ops and sns ice work to stimulate and align complementary activities across the wider community of 6g sns stakeholders sns coop will also ensure the long term continuity of the sns facilities for subsequent phases of the sns ju in addition the sns coop project will provide the support for the eucnc 6g summit events in 2025 and 2026 building on the 6gstart achievements and experience the sns coop project will provide an experienced competent project team that builds on the recent experiences of the sns ops and sns ice projects team to guarantee a seamless handover of all sns support activities for maximum efficiently and value the sns coop project proposes a comprehensive workplan that from the experience of the participants will deliver the expected outcomes and impacts as specified in the work programme particular care was taken to dimension the tasks appropriately for the likely scale and significance of the contributions from the projects the sns coop team will use measurable parameters to regularly assess the dissemination and communication effectiveness which will facilitate monitoring and improving the suitability and quality of the project work with a view to maximising the expected impact of the sns initiative in partnership with all running sns projects
small molecule heparanase inhibitors as antimetastatic cancer drugs

the heparanib proofofconcept project aims to establish the feasibility of our unique small molecule heparanase inhibitors as drug candidates for the treatment of metastatic cancers to strengthen our science case experimental development a and by building on our in vivo data in mouse models for metastatic breast cancer lung cancer and multiple myeloma we will ai design a suitable route of synthesis to prepare sufficient quantities of clinical grade material aii synthesise reference compounds and aiii perform initial pharmacokineticspharmacodynamics pkpd studies with the aim to prepare for the establishment of a spinout biotech company business development b to take our leads towards the clinic we will biv strengthen our intellectual property ip position bv perform an extensive analysis of the antimetastatic cancer drug market and bvi prepare for commercialisation by consolidating the results in an investorready business plan to develop and commercialise our anticancer drug candidate
economic and financial impacts from rapidonset compound and cascading climate related risks

rapidonset hazards often compound ie combination of multiple hazards or cascade ie when a single hazard triggers a sequence of secondary hazards being a main source of concern for disaster and financial risk mangers due to the potential massive direct eg capital stock destruction and cascading indirect economic eg employment and gdp social eg inequality and financial eg public debt impacts while the current understanding on how rapidonset compound and cascading climate related roc3 hazards interconnect is progressively improving less attention is given to how roc3 risks lead to direct and cascading indirect impacts the research theme proposed in this project proposal will advance the understanding of roc3 risks by building on stateoftheart risk models to tackle three interconnected research gaps related to the need for i identifying which how and where roc3 risks may occur ii reliable roc3 direct impact estimates and iii a comprehensive and dynamic assessment of the cascading indirect impacts of risks building on an innovative analytical framework that integrates disciplines from different scientific fields including environmental social and economic sciences the project will be the first of its kind to develop and apply a comprehensive methodological framework integrating the intrinsic dynamics of roc3 risks and the cascading macroeconomic and financial indirect impacts the researcher and two host institutions will mutually benefit from threeway transfer of knowledge by providing openaccess datasets and opensource software the project results have the potential to inform disaster and financial risk managers and promote the conditions for building resilience to roc3 risks the project is aligned with the sendai framework for disaster risk reduction and the paris agreement
autoxitus molecular mechanisms and noncell autonomous signalling

cells control their content by balancing its synthesis and degradation autophagy is a key degradation process capable of engulfing large fractions of cells including organelles into doublemembrane vesicles called autophagosomes these fuse with lysosomes causing degradation of their cargo secretory pathways including secretory autophagy offer an alternative option to remove unwanted materials from cells however mechanisms allowing the secretion of larger cellular components are still unknown we identified a novel pathway which we termed autoxitus for self auto exit xitus that leads to the secretion of autophagosomes this proposal aims at defining the molecular mechanism and regulation of autoxitus we will first study how specificity and decisionmaking between secretory autoxitus and degradative autophagy routes is achieved and whether there is crossregulation autophagosomes on the autoxitus route can contain parts of the cytosol but also large fragments of organelles raising the question whether the secreted autoxitus vesicles signal to neighbouring cells in a noncell autonomous manner we aim to uncover the impact of these signalling processes to determine whether and how autoxitus helps to signal stress conditions or may even deliver material or organelles to other cells finally the role of autoxitus in two pathophysiological conditions will be analysed since autophagic processes are key to viral particle release we will study the contribution of autoxitus to the viral life cycle furthermore we will investigate the role of autoxitus in the release of protein aggregates from cells and the resulting seeding propensitythis proposal will give groundbreaking insight into autoxitus its molecular underpinnings and physiological consequences autoxitus will provide the framework for future integration into numerous cellular pathways