Dragon09/odtu_chatbot huggingface dataset:
the latin church and the waning of greek sicily the case of patti c 10851266

during antiquity sicily was a part of magna graecia and was still a hub of greek civilisation under the byzantine empire after being taken over by the arabs 9th c and then by the normans 11th c greek culture continued to thrive however by 1200 sicily had undergone a nearcomplete latinisation what caused this cultural shift to occur despite the significant impact of the norman conquest and immigration from the continent the waning of greek society was primarily caused by the establishment of the latin church while most narrative sources overlook this major transition the best evidence can be found in documentary sources although latin charters which primarily focus on the royal government have been studied it is important to also explore greek charters the richest source of the daytoday processes that transformed sicilian society the diocesan archive of patti prov of messina provides valuable insights into this historical transformation in the late 11th and 12th centuries patti lay on the cultural frontier between the predominantly greek northeast of sicily and the heavily arabised west and centre despite islamic rule a few greek monasteries managed to survive when the normans took over the greek church experienced a resurgence and greek was the mostly used administrative language however when sicily passed to henry vi in 1194 and latin became the sole language of administration greek culture was already in decline waningreek studies the latin churchs role in the transition of greek communities i plan to produce a reference edition of the greek charters of patti and to use the latin archives to produce a historical monograph my goal is to make these sources accessible to future scholars and to provide an enlarged and detailed account of the process starting from a local level i will demonstrate how cultural changes occurred during the middle ages and how this approach can enrich the history of the entire mediterranean area
synthetic circular rna therapeutics for prevention of sepsisassociated organ failure

reversing organ failure a leading cause of death in sepsis requires specific modulation of biological pathways in endothelial cells which is currently not possible with the existing drugs available employing rnabased drugs to control protein expression could offer a novel therapeutic strategy in the fight against sepsiscircular rnas circrnas are a new class of noncoding rnas with a unique closedloop structure that could help address the current limitations of the rna drugs in the disease context and open new therapeutic avenues therapeutic delivery of engineered synthetic circrnas can allow taking full advantage of their unique features and functions including increased intracellular stability the ability to affect multiple biological pathways by sponging microrna or proteins and their potential for cellular contextspecific control of protein expression via internal ribosome entry site iresmediated capindependent translationi recently codeveloped methods for the circularization and purification of large synthetic circrnas and pioneered their use for robust and stable protein expression in eukaryotic cells to address the short halflife of mrna in biological systems i also synthesized a new type of degradable polymers that enable tissue and celltype selective delivery of large rnas with low toxicitybuilding on those findings circle aims to expand the toolbox of therapeutic rnas by engineering novel synthetic circrnas for modulation of protein expression in sepsis wp1 and wp2 and investigate the potential of synthetic circrna delivery for developing rnabased pharmacological intervention to reverse sepsisassociated lung and kidney failure wp3 and wp4 by addressing an important gap in the knowledge on the utility of circrnas for translational research the scientific impact of circle will extend across the research fields of pharmaceutical sciences synthetic biology and medicine
green innovation strategies for animal health management towards sustainable aquaculture

grinnaqua is conceived in compliance with the farm to fork strategy and is focused in capacitating ciimar to raise staffs research profile and increase its innovation capacity positioning the institution among the main actors in the area of aquaculture recognized leaders in rd within european aquaculture with a solid background in relevant areas partnered with ciimar their profiles make these the ideal partners to push ciimar towards scientific excellence and competitiveness iniacsic spain has significant expertise on the study of fish acquired immune system and vaccination strategies roslin institute univ edinburg uedin uk team has essential knowhow in genetics and animal breeding and univ bergen norway is proficient in the area of animal health and prophylactic strategies clear strategies are defined to raise staffs research profile and excellence by implementing training workshops and summer schools led by the partners several visits of ciimars staff to partners facilities are planned targeting senior research technical and administrative training allowing the exchange of knowledge and good practices the research project integrating partners scientific and technical strengths will in focus in the high economic impactful viral and parasitic outbreaks in aquaculture studying the prophylactic effects of functional diets in rainbow trout against haemorrhagic septicaemia virus and in atlantic salmon infected sea lice parasite this proposal outlines strategies to increase stakeholder interaction and its mobilization towards scientific achievements strengthening ciimars marketdriven research and innovation capacity to increase its competitivity at national and international levelsgrinnaqua will be instrumental to improve ciimar innovation capacity to become a leading institute for the blue revolution in aquaculture a longlasting collaboration is foreseen contributing to strengthen a more sustainable aquaculture in europe
training for organoids modelling physiology and pathology in the human gastrointestinal tract

in the aging society disease burden such as degenerative diseases and cancer are rising while drug development successes are limited due to high drug failure rates in the transition from animal experimentation to human patients this demands rethinking of the currently used models advances in stem cell biology and microfluidics have created new human organ models these models are neither fully understood nor fully mimicking the complexity of the tissue with this new ability to build human stem cellbased models we have a responsibility to drive these models to implementation aiming to replace animal experimentation and provide next generation patient avatars for precision medicine topgut combines cuttingedge basic and translational science with an outstanding program of education to unleash the full potential of new human organ models specifically patientderived organoids and organonchip devices topgut will focus on the gastrointestinal gi tract which is the bodies second largest interface with the environment it is medically highly relevant not only as a major site of cancer development as target of infectious agents and as site of inflammatory diseases but also as one of the major organs for drug uptake and relevance in toxicology topgut aims to significantly contribute to our understanding of the current gi models establish new tools and protocols for more complex gi models and advance the use of gi models for personalised medicine in addition topgut will address ethical and legal issues to foster acceptance and implementation of the gi models topgut will build a solid european network to cooperate standardize and push gi models into applications bringing together academia and industry together topgut educates the next generation of researchers to become new leaders in the field and to drive the implementation of new stem cell based human models to replace animal experimentation in academia and industry
biosim m2m molecules to medicine

biosimulytics has developed breakthrough technology combining quantum physics computational chemistry machine learning and highperformance computing to boost the success rates of pharmaceutical rd the biosimulytics invention patent ep3948877a1 is being applied to crystal structure prediction csp for determining the most stable crystal structure or polymorph of a drug compound as well as the most stable binding poses in proteinligand complexesexisting stateoftheart techniques for polymorph analysis require long and painstaking experimentation by material scientists with uncertain results 1 success rates biosim m2m will reduce the time to find the most stable crystal structures of a molecule from 3 months to 3 weeks and reduce candidate experiments from 400 to 40 as a result biosim m2m will contribute to the pharmaceutical strategy for europe by helping to ensure that patients have access to high quality effective and safe medicines
bilberry ecology and the regeneration of forest ecosystem functioning

human impacts such as clearcut harvesting have left forests bereft of the organisms that underpin their functioning the decline of key plant species has reduced the capacity of forests to store carbon c and provide ecosystem services to the people of europe the regeneration of forest ecosystem functioning requires a deeper understanding of how the traits of its species can be linked to ecosystem processes the bereft project aims to elucidate how the plant traits of bilberry vaccinium myrtillus modulate the dynamics of c and nitrogen n within the boreal forest the project combines advances in chemical ecology with an innovative experimental design situated in norway pairing experimental plots in formerly clearcut forest plantations with those from nearnatural forests i will collect a comprehensive set of bilberrys chemical traits and test both insitu and invitro experiments to determine the underlying mechanism linking bilberry traits to c and n dynamics the project goes beyond the stateoftheart in applying novel methods from chemical ecology to measure bilberrys traits and uses a creative design to link those traits to ecosystem functioning through the scope of traits measured and the innovation in experimental design pairing clearcut forests with nearnatural forests this project will significantly advance our knowledge of the ecology of europes forest ecosystems i will receive training in chemical ecology to advance my career as an expert in data generation and exchange with the host my knowledge on longterm ecological experimentation and ecosystem functioning the project will disseminate deliverables in trait data packages an opensource chemical ecology pipeline and a robust measure of the effect size of bilberrys impact on c and n in the boreal forest knowledge of bilberrys role in the forest c cycle can be exploited by forestry managers in efforts to maximize c storage to meet the eus goal of carbon neutrality
rm framework creating a european framework for research management training and networking

rm framework endeavors to strongly enhance research management within the era and beyond by fostering clarity interoperability and sustainability in the diverse rm landscape this ambitious initiative aims to engage diverse stakeholders by establishing a common frame of reference for rm by involving national clusters training providers funding agencies ministries and other rm actors and networksthe project looks to tailor training approaches to meet the varied needs of research managers across europe by utilising extensive networks to gather diverse perspectives and insights to tailor training approaches to offer comprehensive training from general europeanlevel programs to specialised initiatives the project will explore various training methods including communitybased informal and formal university alliancesthis will all be achieved whilst also acknowledging national and local differences by bringing together pilot testers from 9 countries ensuring inclusivity and relevance incorporating leadership perspectives to align rm practices with organisational goals policy frameworks and the policymakers to ensure policy synergies and effective implementationby learning from past challenges and leveraging the expertise of diverse stakeholders the rm framework project aims to avoid previous pitfalls and achieve sustainable impact with a strong consortium and a 24month timeline the project is poised to deliver tangible results in the rapidly evolving landscape of research assessment open science and ai integration moreover by developing a quality label and fostering collaboration with existing networks the project seeks to ensure longterm relevance and sustainability beyond its duration ultimately the rm framework project represents a critical step towards enhancing the effectiveness efficiency and impact of research management practices across europe and beyond
the mechanics of canon formation and the transmission of knowledge from graecoroman antiquity

to consider a text or author canonical is to invest it with prestige authority or even timeless value canons set standards and define what is deemed worthy of transmission but at the same time they are constantly undergoing change the distinction between those who belong to the canon and those who do not inevitably operates a dynamics of inclusion and exclusion it is not clear however who if anyone is the agent of such operations and what influences the way canons are shaped mecano the mechanics of canon formation and the transmission of knowledge from grecoroman antiquity aims to advance our understanding of the mechanics of canon formation and knowledge transmission of ancient greek and latin texts it will look at a how texts ideas or authors become canonical by being cited translated studied imitated excerpted or compiled by later authors and b how such implicit canons have changed across time and space by being received in different cultural intellectual and linguistic environments to study the dynamics of canonicity from a longitudinal perspective mecano will combine qualitative approaches to intellectual history and reception studies with applications of digital and computational methods on extensive text corpora bringing together six universities and an array of academic and nonacademic institutions interested in the topic of canonicity publishers museums academies of sciences national libraries arts companies as well as a centre for entrepreneurship and an ict company mecano created a training programme that responds to the need for historically conscious and digitally skilled humanities phds mecanos twofold goal is to develop a new model for the study of canonicity and to train the phd researchers to become versatile intellectuals ready to tackle the challenges of modern engagement with the topics of canonicity diversity and cultural heritage
hopeful and resilience perspective in climate change education to inspire promote action competence

the harp hopeful and resilience perspective project a collaborative endeavor involving masaryk university university of utrecht and university of vienna targets the gaps and inconsistencies in climate change education cce across europe harp is designed to foster actionable inclusive and emotionallyengaging cce strategies to promote climate change mitigation masaryk university renowned for its focus on climate change education acknowledges the need for a quantitative approach to cce expertise currently excelling at utrecht university with specialists like boevede pauw jelle and a mixed method found in vienna with the likes of andrea moellerharp identifies the uneven state of cce in europe often fragmented and insufficiently integrated into national curricula its objective is to transform cce into a primary driver for climate action making cce more holistic by incorporating various disciplinary perspectives the project is designed to offer actionable recommendations ultimately aiming to cultivate a climateliterate populace pivotal for the imminent climate challenges acknowledging that existing cce often overlooks the emotional dynamics of climate change which significantly influences action engagement harp promotes a comprehensive approach to cce source the initiative targets two primary objectives firstly enhancing the capacities of partner institutions for climate change education research ccer emphasizing strengthening research design and improving the overall ccer quality across europe secondly the formation of a european cce and ccer network to bolster collaboration and share findings complemented by national and international advisory boards in sum harps intent is to uplift the quality breadth and influence of cce enabling a community of learners educators and researchers equipped to significantly contribute to climate change mitigation
engineering metal halide perovskites by vapour deposition

metal halide perovskites mhps have been in the spotlight of scientific research for over a decade due to their remarkable properties and performance in solar cells their future relies on a deeper understanding of their fundamental properties better control of their structure and implementation by scalable deposition methods while most research efforts are dedicated to the solution processing of mhps vapour deposition holds many benefits it is a solventfree scalable method of high industrial relevance offering high throughput homogeneity material economy safety yield and controllability despite these clear advantages the development of engineering approaches to precisely control the properties of mhps by vapour deposition remains in its infancy in perovap i will develop novel routes for engineering mhps by vapour deposition and the fundamental understanding of their growth and crystallisation thus enabling new material structures with tailormade properties i will establish structural control over the phase orientation and microstructure of mhps by additive engineering and develop a new class of perovskiteorganic hybrid semiconducting composites i will also demonstrate efficient controllable n and p electrical doping of vapour deposited mhps and create graded mhp layers with tailored optoelectronic properties and energetic landscape to realise this i propose a unique combinatorial fabricationcharacterisation methodology for their insitu spectroscopic characterisation this approach will allow to efficiently explore the multidimensional parameter space required to engineer the mhp properties and enable the development of the fundamental understanding of the film formation processes finally to reveal the structureproperty relations the engineered mhps will be integrated in novel solar cell architectures the approaches developed in perovap will open a new path for mhp electronics and optoelectronics far beyond stateoftheart
compressed indexes for regular languages with applications to computational pangenomics

sorting is arguably the most powerful algorithmic primitive when it comes to indexing data at the same time the regularities exposed by sorting are precisely those enabling data compression in the last two decades this fascinating duality has led researchers to the design of compressed fulltext indexes data structures supporting fast pattern matching queries over compressed text in this project we revisit the natural generalization of the problem to labeled graphs from a new perspective we interpret graphs as finitestate automata and investigate the connections existing between their propensity to be sorted and the languages they recognize our novel languagetheoretic approach makes it possible to transfer fundamental results between the mature fields of regular language theory and compressed text indexing we aim at building this bridge by developing a new theory of compressed regular language indexing this project finds fundamental applications to the rapidlyexpanding field of computational pangenomics where the goal is to study the variations contained in the genomes of an entire population recent research has shown that representing pangenomes as labeled graphs is an important step to reduce reference allele bias existing approaches however can index only restricted classes of graphs thereby limiting the practical applicability of such powerful pangenome representations our innovative approach based on sorting regular languages by partial colexicographic orders changes the perspective from which the compressed indexing problem has been tackled in the literature this project aims at developing a theory of graph indexing and compression based on the natural interplay between sorting and regular language theory we will apply these findings inside practical tools for aligning arbitrarilylong dna fragments against compressed pangenome graphs
distributed wireless eeg sensor patches for auditory attention decoding in hearing technology

over 400 million people worldwide suffer from disabling hearing loss while the majority can be helped with a hearing aid users still experience major difficulties in situations where multiple people talk simultaneously leading to social isolation although algorithms exist to extract a single speaker from such a speech mixture the current bottleneck is that a hearing aid does not know which of these speakers the user aims to attendrecent research has shown that this auditory attention can be decoded from the brain via electroencephalography eeg however a practical realization in hearing aids is hindered by current eeg form factors headsets are too bulky while miniaturized sensors lack a wide scalp coverage furthermore conventional eeg requires applying a gel on the skin which dries out over timeto address these issues we propose a novel modular approach using 4 wireless eeg sensor patches strategically positioned on hairless scalp locations this offers several advantages such as 1 increased scalp coverage for improved decoding accuracy while maintaining comfort and discreteness due to a fardriven miniaturization and absence of wires 2 the use of dry adhesive patches with skinconforming microneedle electrodes for highquality eeg recording without gel 3 efficient algorithms that process signals and exchange compressed data wirelessly over short distances with minimal energy usage thereby maximizing battery lifein this project we will develop an operational prototype of this system drawing from our recent ercoriginated innovations and validate it on hearingimpaired subjects