Dragon09/odtu_chatbot huggingface dataset:
theranostics ecosystem for personalised care

thera4care represents a large unique consortium gathering wellestablished european academic radiotheranostic centres strong industry partners european and medical societies focusing on training and education a patient advocacy group spearheaded by an experienced project management group thera4care aims to establish a european network of radiotheranostics centres able to rapidly develop and implement radiotheranostics tools and solutions to drive precision health the overarching vision of thera4care is to revolutionise radiotheranostics procedures by establishing implementing and disseminating standardised scalable methods to produce and efficiently administer key radiotheranostics solutions thera4care focus is on developing diagnostic and therapeutic ligands tailored to key disease areas such as solid tumours aligning with the growing significance of multimodal radiotheranostics solutions dominated by radionuclidebased therapy and companion diagnostics thera4care project is scheduled for 5 years and consists of 9 work packages wp1 handles project management wp2 focuses on regulatory aspects wp3 plans preclinical studies wp4 provides supply chain wp5 develops clinical trials wp6 generates ai models wp7 focuses on dosimetry wp8 develops precision imaging components while wp9 focuses on education and dissemination thera4care will advocate for the progress of radiotheranostics with the goal of increasing medical knowledge and enhancing treatment efficacy for improved patient outcomes concurrently aims to coordinate scientific initiatives across european landscapes leveraging a comprehensive and multimodal approach to cancer therapy applicable to various cancer types lastly will work on the establishment of sustainable supply and production networks and the upscaling of production methodologies and supply chains across the public and private sectors to enhance the availability of radionuclides
advanced ai based metasearch platform in photonics

meetoptics is a deeptech startup founded by dr brbara buades and dr james douglas ceo ameetoptics is a deeptech startup founded by dr brbara buades and dr james douglas ceo and cto previously researchers from the institute of photonic sciences icfo and the university of oxford it is a disruptive solution unique in the global market being the first specialized search engine for realtime photonic components thanks to the development of artificial intelligence ai algorithms and neural networks it allows the global scalability of help and professional and precise technical guidance in this market the field of photonics is rapidly growing today there are more than 100000 optical components with which to manufacture lasers microscopes or spectrometers having approximately 30 technical aspects each crucial to the final performance professionals spend weeks and even months to select a single component exploring a small fraction of suppliers not knowing most of the time what they really need creating major industry disruptions meetoptics will provide a service through ai together with a realtime metasearch engine helping professionals match their technologies and helping suppliers and professionals refine their real needs meetoptics will shorten out photonics technology developments time and will improve companies throughput meetoptics is seeking women techeu funding to develop new advanced ai algorithms to scale up its database from 40000 to 200000 products validating its responsiveness to market demands from 100000 test users and saving time and resources to professionals and manufacturers it is a 9month project that is expected to start in 2022 the first day after the signature of grant agreement to subsequently go to market at the beginning of 2023in addition the women techeu mentoring and coaching support represents a great help to validate the business strategy identify new business multipliers and access new investors and partners internationally
3d integrated photonic nanostructures with giant optical nonlinearity

photonics has a major impact on technological innovations and can revolutionize the field of computing and data processing due to its high bandwidth speed and low power consumption this has already happened for data communication via fiberoptic connections while light processing in embedded systems is still performed by electronics via powerhungry opticalelectrical conversionthe future development of integrated photonics is then waiting for new integrable materials that can advance the functionality of photonic chips towards alloptical signal processing at very low light intensities while linear operations and parallel matrix multiplication can be efficiently performed by light nonlinear optical functions are notoriously difficult to implement because they require a suitable medium for efficient photonphoton interaction currently there is a lack of materials with large thirdorder nonlinearity high speed and easy processability and integration in 2d and 3d structures3dnanogiant aims to develop new nonlinear photonic materials that can be integrated into heterogeneous functional platforms or chiplets to this end i will exploit the giant optical nonlinearity of liquid crystals ten orders of magnitude larger than that of silicon for new formulations and lithographic strategies by which the liquid crystals will be confined in a printable nanoporous polymer network their 3d nanopatterning will enable the production of multidimensional hybrid nonlinear photonic devices from alloptical 2d logic gates and ultrafast nonlinear activation functions to selfoscillating 3d photonic crystals in parallel the propagation interaction and polymerization of solitons in a 3d1 space will lay the foundation for a new unsupervised bottomup 3d printing technology the goals of 3dnanogiant will redefine the stateoftheart in integrated nonlinear photonics with practical and versatile heterogeneous chip for fast and energyefficient optical processing
effect of insulin and feedfast cycle on vaccine efficacy and safety

though it has long been known that activated lymphoid cells upregulate insulin receptors the functional relevance of insulin signalling in immune cells has only recently begun to be explored this includes the recent finding that insulinstimulated activation in the pi3kaktmtor promotes immunometabolic reprogramming of t cells thereby promoting antigenspecific immunity similarly in liver cells insulin receptors have been shown to translocate to the nucleus where they participate in regulating genes involved in viral response and epitope presentation whats more various lines of evidence have implicated inulin signalling in the development of coagulopathies via its effect on the expression of cytokines complement and clotting factors whiles also affecting platelets and endothelium taken together these and other observations implicate an underappreciated immuneregulatory function of insulin yet even basic questions regarding insulin signalling in immune cells eg do t cells develop insulin resistance are currently unknown in the proposed study we will investigate the effect of insulin signalling in immune and nonimmune cells to evaluate the impact of insulin signalling on these immunerelated functions firstly we will leverage publicly available proteome and transcriptome data to reinterrogate these data sets from an immunological perspective complimenting these activities we will also conduct detailed cell culture experiments to evaluate the effect of a does and b duration of insulin on the release of clotting factors cytokines and complement as well as immune cell activation and polarization finally we will conduct a vaccine trial on a rodent model to evaluate the effect of insulin on vaccine efficacy beyond t1d and t2d these findings will also impact diabetic care in organ transplant gestational diabetes and the development of preeclampsia immunotherapies and intensive insulin therapy in criticalintensive care
acorns revaluation for human consumption genomic selection and development of new functional foods

the objective of acofood is to promote the consumption of acorn by human beings as it is a nutritious fruit with high production in the mediterranean region selecting the genotypes with the best functional characteristics for the consumer identifying markers related to healthy phenolic compounds and the absence of astringency and cytotoxicity and developing a healthy acornbased food dr mara vzquez is a researcher with a scientific background in the field of postharvest of fruits and biomedicine with great motivation to be able to combine these two disciplines contributing to the implementation of a healthy and sustainable diet
characterizing the chromatin landscape of spinal muscular atrophy in response to aav9 mediated gene therapy

spinal muscular atrophy sma is a fatal neurodegenerative disorder in children characterized by motor neuron loss and atrophy of muscle however sma affects many organ systems since the causal gene smn1 is expressed in all cells recently an aav9mediated gene therapy zolgensma was approved however challenges remain to be effective the systemically delivered aav9 smn1 needs to mimic the native regulation of the genomic smn1 in fact recent findings demonstrated that delivery of aavsmn1 under the control of the ubiquitous viral promoter cmv found in zolgensma eventually caused death of neurons in a mouse model of sma to date there has been no systematic categorization of how treatment with smn1 is regulated in different tissues through development furthermore little is understood about the chromatin changes that occur during sma how gene therapy impacts the longterm stability of patients epigenomes or how the aavdelivered dna is epigenetically controlled over time the goal of the proposed work is to understand how the epigenome reacts to gene therapy using sma as a model to do so i will i profile the epigenetic changes during sma disease progression in mice before and after gene therapy ii evaluate the role of various promoterenhancer structures in the vector on the epigenetic regulation of aavdelivered episomal dna and iii test if endogenous promoterenhancer combinations can be used to achieved a better tuning of the delivered gene the proposed project combines the expertise of dr piera smeriglio in sma models neuromuscular disorders and gene therapy with my expertise in epigenetic profiling gene regulation functional genomics and singlecell technologies aav gene therapies are poised to have a huge impact on rare diseases a key priority of the horizon europe programme making now a critical time to understand their effect on the epigenome and cell regulatory networks to increase the efficacy and safety of their use
bridges in social networks harnessing dual identity to improve interethnic relations

improving relations between ethnic minority and majority groups is one of the most pressing needs in modern societies this project will test a new theory that such relations can be improved by minority members who identify with both their ethnic group and the national majority group because these dual identifiers can create social bridges between communities however not all dual identifiers are recognized as such by others and misperception may undermine the bridging that dual identifiers can accomplish i propose that a dual identifiers relationships with members of both groups are signals of their dual belonging but that the degree to which these signals are picked up depends on peoples perception of the structure of their social networks b that perceiving dual identifiers improves intergroup attitudes and relationships and c that these effects occur most likely under specific situational and social psychological conditions thus this project will advance the interdisciplinary fields of intergroup relations and network science by moving away from the problematic assumptions of previous work that people are always fully aware of others dual identities and relationshipsi will develop and test a pioneering methodology to measure perceptions of peoples ethnicity and their relationships in social networks survey experiments and a two and threewave longitudinal school study will then be conducted to 1 detect how perceived relationships in social networks affect recognition of dual identifiers 2 uncover whether and how perceiving dual identifiers as social bridges improves interethnic relations and 3 discover factors that prevent or facilitate the effect of dual identifiers next to the theoretical innovation the focus on the consequences of perceived social networks will break new ground in social network analysis the findings will lead to new approaches for facilitating the development of positive interethnic relations
pulmonary delivery of anticancer drug via an inhaled responsive nanogel with stealth ability and high targetability

in this project i will investigate and develop nanogels incorporated into microgels containing encapsulated anticancer drugs these nanogels will be delivered via the respiratory system to the lung selectively swell and deliberate the therapeutic importance will be given to targeting moieties stealth moieties and biocompatibility the delivery of drugs for lung cancer is limited but is under investigation and on the rise of inquiry some of the challenges this type of technology faces are the efficient encapsulation of the bioactive compound inside a nanocarrier the targeted delivery the release of the drug the biocompatibility with the lung and the avoidance of the macrophages new methodologies for better delivery of therapeutics are of great importance at the national and international levels new materials and technologies are emerging every year the delivery of therapeutics for lung cancer is based mainly on intravenous therapies another way of introducing drugs into the area of importance in the lung could be pulmonary drug delivery as a good alternative pulmonary delivery is not a new technology but is strictly limited to specific conditionsillnesses the research capitalizes on the existing strengths of the experienced researcher er in polymer science and the expertise of the host institute in chemical biology in health drug research and biotechnology it will lead to several publications in highimpact factor journals transfer of knowledge and expertise that could be capitalized at an industrial level thus contributing to the research output distinctness and economy of europe overall the fellowship will allow the er to reintegrate into a longterm academic position after many years of fruitful research career in the academic sector in spain after this project the er will obtain new knowledge and training that will help him to establish a solid point for a better opportunity both in academy and in industry
raw material provisioning and mobility patterns throughout the middletoupper palaeolithic transition in nw tuscany

mobility investigates middle and early upper palaeolithic human organisation to exploit the landscape resources in nw tuscany huntergatherers hgs mobility patterns are understood to be in a spectrum between residential and logistical mobility hgs have shown to have sitefurniture personal and situational gear with different levels of manufacture and maintenance curation around 40 ka cal bp a technological and human species shift occurred in europe referred as the middleupper palaeolithic transition the northern tyrrhenian region is one of the few european areas that yielded a cluster of last neanderthal sites and the presence of early h sapiens it is a required passage between southern france and the rest of the italian peninsula and the further investigation of this area could shed light on the colonisation process of h sapiens and its relationship with the demise of h neanderthalensis the sites in nw tuscany are showing a different raw material provisioning in particular early h sapiens introduced the exotic scaglia marchigiana chert showing a longextended network that spans from nw italy until the central eastern apennines the action is an interdisciplinary endeavour to better understand differences of landuse patterns and reconstructing mobility patterns in the nw tuscany across the middleupper transition period through the technological analysis of the artefacts and the definition of raw material circulation
cloudnative ultrasound imaging

ultrasound us can revolutionize and democratize medical imaging if it offers 1 access for everyone and 2 excellent image quality always mri offers 2 but is expensive and will thus not likely be able to provide 1 lowcost us hardware will enable 1 in the future but is not expected to yield the needed breakthrough for 2 any solution that addresses both will have a huge impactthe biggest adversaries for us image quality stem from patient and userspecific factors i therefore strongly believe that achieving 2 requires closedloop goaldirected imaging through systems that actively pursue information gain insitu my erc stg project usact develops this new closedloop us paradigm with deep generative models governing beliefs about anatomy and function this however gives rise to a new dilemma how to embrace highperformant but complex algorithms to achieve 2 while at the same time lowering cost to achieve 1 our recent result shows that usact enables breaking the costcomplexity tradeoff through a new approach that is rooted in the closedloop proposition itselfi propose cloudsound a fully cloudnative us imaging paradigm unlocking access to virtually unlimited computational power memory and storage for raw us sensor data we will move all the computational complexity away from the local device to a remote server to achieve this with minimal latency and high frame rates cloudsound introduces a new holistic rate control strategy for the entire transmitreceive scheme based on algorithms developed in usact this will drive rate control of the full solution under a timevarying information bottleneck the network channelultimately cloudsound will disrupt ultrasound business models and unlock unprecedented image quality and ease of use making advanced medical imaging affordable and globally accessible
deciphering cellular signalling to cure graftversushost disease gvhd and leukemia relapse

acute graftversushost disease gvhd and leukemia relapse cause 75 of the mortality of patients having undergone allogeneic hematopoietic cell transplantation allohct a better understanding of signalling in immune cells tissue specific cell types and leukemia cells is key to develop novel therapies against gvhd and leukemia relapse the ambitious overall goal of allocure is to identify the pathogenic events that initiate gvhd 1 maintain therapyrefractory gvhd 2 and mediate immune escape causing leukemia relapse 3 to address these high riskhigh gain questions novel methods and developments across disciplines are required 1 i hypothesize that a loss of to date unexplored intestinal enteroendocrine cells promotes gvhd initiation to study these small cell subsets we will use reporter genes and novel imaging methods to systematically evaluate their fate and signalling during intestinal gvhd 2 signalling propagating refractory gvhd is not wellunderstood our phosphoproteomics data set from corticosteroid and ruxolitinibrefractory gvhd patients will instruct selective analysis of kinase activation in immune cells and enterocytes by using genetic creloxbased and pharmacological approaches 3 i have shown that leukemiaderived lactic acid inhibits glycolysis and mekerk signalling in t cells thereby impairing graftversusleukemia gvl effects here i will decipher which other leukemiaderived metabolites mediate pathogenic signalling in immune cells and test if oncogenic signalling in leukemia cells drives immunosuppressive metabolite production to enhance gvl we will inhibit pathogenic kinase activation in leukemia cells and myeloid suppressor cells using high riskhigh gain approaches in a combination of murine and human studies allocure aims to develop individualized therapeutic strategies to interfere with pathogenic signalling responsible for gvhd or leukemia relapse to reduce the mortality rate of patients undergoing allohct
when was greenland green perspectives from basal ice and sediments from ice cores

green2ice will investigate the deepest and oldest ice and basal sediments drilled from the greenland ice sheet gris ice cores have been drilled the last 55 years but the deepest ice containing basal materials has been preserved until now and still holds undeciphered paleoclimatic messages the breakthrough of green2ice is to develop and apply cutting edge dating methods on this unique sample collection and hence to reconstruct the age and the stability of the gris a hypothesis to test is if the present gris formed at the time of the mid pleistocene transition 12 08 million years ago one innovation of green2ice is to gain paleoinformation of the past size of the gris to constrain future tipping points this knowledge will reduce the uncertainty on estimates of future sea level rise green2ice will bring together four pis from three world leading institutions with complementary skills to lift this strongly interdisciplinary program we will drill a replicate core at grip to supplement the available material from five existing ice cores and ensure retrieval of sediments and rock material from beneath the gris summit we will develop improve and apply novel dating techniques cosmogenic and radiogenic nuclides oslirsl modeling of gas and isotope diffusion to place constraints on past waxing and waning of the gris stateoftheart methodologies on fossil remains organic matter in situ produced and consumed greenhouse gases and ancient biomolecules will provide insights on the types of ecosystems and environmental conditions that emerged during icefree conditions interpretation will include ice sheet modelling with data benchmarking to establish the climatic sensitivity of the gris earth system modelling and collaboration with the groups preparing the ipcc ar7 will bring the knowledge of the past into the future the rare and unique basal ice and material can only be used once this is the main high risk high gain component of green2ice
selfcontracting vascular networks from fluid transport to autonomous locomotion of soft materials

liquid flows in vascular networks are among the most effective ways to transport matter and information for life artificial vascular networks have mimicked this strategy without reproducing the same level of autonomy and adaptability from animals to fungi the most adaptable organisms control fluid transport with vessels that actively contract upon local sensing of stimuli this adaptative fluid transport enables functionalities in organisms such as autonomous locomotion toward objectives how are the orientation and rate of fluid flows controlled by selfcontractions how do these selfcontracting networks tailor autonomous functionalities so far we do not know studies on organisms are limited to observations and lack the systematical characterizations required to apply these observations to artificial materials selfflow hypothesizes that artificial vascular networks containing distributed sensors and actuators can decipher how selfcontractions enable adaptable fluid transport from there materials containing selfcontracting artificial vascular networks will enable systematical studies on the emergence of autonomous functionalities with this experimental asset reinforced by theoretical and numerical models my group and i will address the following questions q1 deliver how do selfcontractions transport fluids across networksq2 adapt how do selfcontractions autonomously adapt to the need of the network q3 behave how do selfcontractions enable living matter functionalitiesselfflow will combine active matter and mechanistic approaches to model fluid transport in selfcontracting vascular networks i will use these results to design active vascularized materials that use fluid transfer to autonomously locomote towards objectives and exchange information with their pairs this will open the way to autonomous robots that can change shape split or recombine like soft materials and develop functionalities beyond locomotion