Dragon09/odtu_chatbot huggingface dataset:
integrated circular and digitally supported sustainable solutions for waste minimization and carbon capture in buildings and the construction sector

the construction sector is responsible for over 35 of the eus total waste generation and accounts for about 50 of all extracted resources and an estimated at 512 of total ghg emissions woodcircles will contribute significantly to decreasing these numbers by developing innovative circular solutions for sustainable wood construction to help reduce europes dependence on nonrenewable resources cut ghg emissions reduce waste generation and offer longterm carbon sinks and substitution of fossilbased and carbonintensive products woodcircles will combine the considerable innovation power of the expert consortium consisting of key stakeholders from all parts of the value chain to release the full circular and sustainable potential of wood construction based on identified needs and market potentials the consortium will develop new valueadded value chains for upcycling of wood waste materials and optimized designfordisassembly building system solutions to significantly increase recycling rates of wood in construction an urban sawmill sorting and production facility capable of turning inhomogenous low value wood construction waste into a standardized homogenous valueadded costeffective baseline product will be prototyped woodcircles will integrate digital tools and solutions in all developments and create digital twins for the largescale reallife demonstrators the urban sawmill and the building system prototypes to demonstrate the benefits of digital technology for circular construction active involvement of partner cities and their building ecosystems through technical and thematic coengagement activities will increase deployment all developed materials components and system prototypes will be demonstrated piloted and fully documented including sustainability assessment for immediate market uptake based on developments recommendations for new or updated european harmonised technical specifications and eurocodes will be provided
a new life for people with severe disabling cluster headache neuromodulation therapy using safe minimallyinvasive simultaneous stimulation at the front and back of the head

chronic cluster headache and chronic migraine pose a significant challenge for patients and neurologists worldwide approx 4864 of the patients experience only limited relief from drugbased treatments they are drugrefractory salvia bioelectronics bv developed primus an innovative peripheral nerve modulator to treat exactly these refractory chronic neurovascular headache patients the groundbreaking dualsite stimulation targets both the front and back of the head in ongoing firstinhuman studies primus has demonstrated a 985 effectiveness in reducing the frequency of the debilitating headache attacks 100 patient response rate primus advanced design with a lead of only 01 mm and no large implanted battery significantly mitigates the risks of systemic side effects 0 devicerelated events reported this in contrast to existing and competitive neuromodulation devices that are incompatible with the intricate anatomy of the head placing a heavy and stigmatising burden on patients with severe devicerelated adverse events such as skin erosion and lead displacementusing eic support salvia will fund the clinical pivotal trial regulatory approval and gotomarket for refractory chronic cluster headache this strategic approach aims to prioritise the severe yet comparatively rare cluster headache indication while simultaneously maintaining a strong commitment to the much larger chronic migraine market worth 109b and heavily supported by our investors by leveraging the positive outcomes for refractory chronic cluster headache salvia aims to convince the key partners neurologists to facilitate an expedited market access and penetration in particular for the large refractory chronic migraine market segment as such reaching the full commercial potential of our product driven by its disruptive technology we aim for market launch in europe and the usa in 2026 and accelerated yet sustainable company growth followed by a an ipo in 2027
naovns a new personalized neural stimulation therapy for drugresistant epilepsy

195m world population suffer from drugresistant epilepsy dre with symptoms poorly controlled 8m are not eligible for brain surgery vagus nerve stimulation is nowadays the best treatment option but unfortunately current solutions do not reply to the clinical need they cannot adapt to each patient making the patients therapeutic journey complicated and expensivewe created naovns the nextgeneration implantable vagus nerve neurostimulator we replaced metal wires by optical fibres to convert optical energy to electrical impulses rendering the device compliant with mri brain scans essential for disease diagnosis or treatment through naovns patients physicians receive remote feedback on the direct effect efficacy of the neural stimulation to precisely uniquely adapt therapythrough eic funding we will complete a clinical pilot trial a pivotal study in the euus to initiate market approvals we expect to generate 89m by 2028 selling in the euus
multidisciplinary research cooperation on information suppression and diaspora communities as a target of foreign information manipulation and interference

foreign information manipulation and interference fimi including information suppression concern a series of threatening behaviours in the information domain and represents a major challenge in terms of counteraction and the policymaking in this matter numerous fimi operations carried out by noneu state and nonstate actors often recorded within and beyond eu borders aims to domestically threaten fundamental rights and freedoms and could as well produce threatening effects outside of their borders the resonant project aims to create a better picture and understanding of state and nonstate actors applying information suppression and to recommend strategies tools and methodologies to reduce the impact and the vulnerability of the target groups as the diaspora communities in order to understand which actors outside the eu use in a coordinated manner tactics techniques and procedures ttps of information suppression resonant proposes to analyse information suppression incidents thus creating an evidence base considering both the domestic and crossborder dimensions of information suppression the project will also examine the mainly adopted ttps as well as the available tools for their detection and analysis for enhancing the knowledge regarding the effects of information suppression resonant proposes an analysis of behavioural changes in diaspora communities as result of information suppression and of the awareness and preparation of eu state authorities in terms of practical legal means providing selected case studies furthermore the project will propose the definition of a methodological toolkit and policy recommendations as well as the organisation of table top exercises and focus group policy discussion for addressing information suppression and fimi resonant will realise a handbook of methodologies and policy recommendations contributing to communicate and disseminate practical means to counter information suppression and fimi
center for ethics in public affairs

etica center for ethics in public affairs at the american university of armenia under the direction of era chair professor maria baghramian will become a national hub for analysing and researching key ethical issues in the public sphere etica will carry out its activities under the four pillars of research and internationalisation training and capacity building outreach and public engagement and structural reform focusing on the following objectives to internationalise research through a collaborative research project on trust and hope in a time of polycrises to create longterm research and training resources in ethics in public affairs to offer training opportunities in professional applied and research ethics to engage the public in participatory deliberations on key ethical issues to generate policy briefs informed by its theoretical empirical and participatory findings to encourage reform in research management at institutional and sectoral levels and to assist in strengthening international research funding applications etica will have a lasting impact on the development of research and training in public ethics in a small country with limited resources by recruiting an excellent team of researchers the center will also contribute to revitalizing research and publication in the humanities through its training and capacity building activities etica will promote the development of codes of professional conduct in research and governance by engaging with the general public in the course of town halls youth juries and deliberative mini publics etica will strengthen the practice of open and reasoned discourse on issues of public significance in a postsoviet country steadily moving towards democratisation etica will introduce changes in research management research ethics and funding application governance that will hasten the integration of aua and ultimately the republic of armenia in the eu and the global research community
proof of concept of affordable and scalable dna data storage by developing a writing technology based on enzymatic dna synthesis with a very dense semiconductor integrated circuit cmos chip

the hyperion project will prove the concept of affordable scalable data storage with dna by developing a world beating writing technology based on the precise robust control of enzymatic dna synthesis with a very dense semiconductor integrated circuitthe 4year research project will further develop a breakthrough approach by the deeptech researchintensive company dna script and show that very highdensity enzymatic dna synthesis is feasible furthermore it will demonstrate proof of concept of highdensity chip multiplexing which will be essential to achieve performances commensurate with the bestinclass technologies terabyte capacity and mbs writing speedin the course of the hyperion project we will rely on fabrication and postfabrication facilities located in the eu this will contribute to the strengthening of capacity and expertise in line with the european chips act once the proof of principle is validated the hyperion approach will be the basis for deployable storage technologies that can eventually scale into the exabyte regime and beyond with reduced physical footprint power and cost requirements relative to conventional storage technologies this hyperion project will contribute to the eic pathfinder challenge goal by providing a writing solution fit to meet the future needs of a european dnabased data storage industry the impacts are expected to be immense on science society the environment and the economy at large
experiment driven and user experience oriented analytics for extremely precise outcomes and decisions

extreme data characteristics volume speed heterogeneity distribution diverse quality etc challenge the stateoftheart datadriven analytics and decisionmaking approaches in many critical domains such as crisis management predictive maintenance mobility public safety and cybersecurity at the same time datadriven insights need to be extremely timely accurate precise fitforpurpose and trustworthy so that they can be useful extremexp will handle the complexity of matching extreme needs with complex analytics processes ie processes that involve and combine ml data analysis simulation and visualization components by placing the end user at the centre of complex analytics processes and relying on user intents and running experiments ie trial and error to prune the vast solution space of possible analytics workflows and configurations ie variants its main goal is to create a next generation decision support system that integrates novel research results from the domains of data integration machine learning visual analytics explainable ai decentralised trust knowledge engineering and modeldriven engineering into a common framework the overarching idea of the framework is to optimise the properties of a complex analytics process that the end user cares about eg accuracy timetoanswer specificity recall precision resource consumption by associating user profiles to computation variants the framework is envisioned as modular and extensible orchestrating different services around an experimentation engine analysisaware data integration extreme data knowledge management userdriven automl transparent interactive decision making and userdriven optimization of complex analytics the framework will be validated in five pilot demonstrators
secretariat of global research collaboration for infectious disease preparedness

glopidrsec iii is the secretariat to the global research collaboration for infectious disease preparedness glopidrcharit universittsmedizin berlin charit has decided to fulfil the role of coordinator of the secretariat in close consultation with fondation mrieux fmer previous secretariat coordinator and the university of oxford uoxf continuing key technical partneras glopidr is continuously evolving its organization and structure so must the secretariat evolve glopidr sec iii provides the opportunity to move towards a collaborative leadership model aligned with glopidrs vision aiming to respond to the increased willingness from funders to work together and to the increased work scope for glopidr and the secretariat due to the lessons learned from the covid19 pandemicthe objectives and core activities of glopidr sec iii encompasscore organisational and secretarial services to provide operational secretarial organisational and administrative support to the glopidr organisationcommunication and stakeholder engagement supportoriented services to implement maintain and evaluate an effective external communications and advocacy programme to support communications with glopidr members and stakeholderstechnical supportoriented services to support the further development and operationalisation of glopidrs strategy by providing expert technical and operational support to its executive board and working groupscritically to meet the expectations of glopidr the secretariat must continuously explore and implement key adaptations that improve the effective coordination between international funders and stakeholders for a rapid research response to public health emergencies thus our work plan has been devised to adjust to the anticipated evolution of the alliance and to the changes that occurred during the previous funding period
flexible megawatt charging systems open software architectures and planning modules creating multicharger hubs for the european electric mobility system

for the mass deployment of electric trucks the flexmcs project aims to overcome challenges regarding the acceleration of the roll out of charging infrastructure in expanding grid capacity and available charging infrastructure flexmcs designs highly energyefficient megawattcharging hubs with multiport chargers which improve the utilisation and can be used flexible for hdvs during fast charging but also at night for slower charging and for light vehicles the project will integrate renewable energy sources in the charging hub to minimize energy losses and grid impact furthermore the project will develop tools for optimal utilisation of charging infrastructure and user convenience an open charging framework architecture will create realtime data exchange between cpos and truck to match the supply and demand of charging infrastructure part of the project is also the streamlining of the planning and installation of new charging hubs identification of optimal geographical locations along tent corridors and optimizing hub architecture and layout and addressing technical and nontechnical barriers flexmcs will demonstrate and assess the flexmcs megawattcharging hub concept and upscaling strategy validating technology effectiveness and formulating business cases the project partners include vrije universiteit brussel as the coordinator along with hitachi energy jema energy as charging infrastructure suppliers elaadnl representing grid operators iveco spa and daf trucks regarding the interoperability for trucks bosch service solutions gmbh for access and control systems on the charging hub alfen for stationary energy storage ricardo tno idiada automotive technology sa and austrian institute of technology for the development of tools and algorithms and alice and gruber logistics spa for giving an enduser perspective on all systems
unraveling the role of transgenerational epigenetic inheritance mediated by paramutation in natural animal populations

understanding how organisms rapidly adapt to changing environments is a fundamental question in evolutionary biology transgenerational epigenetic inheritance tei has been proposed as a mechanism that allows organisms to respond flexibly to environmental variation and thus plays a central role in rapid adaptation to fluctuating environments a compelling example of this process is paramutation in which epigenetic information is transferred from one allele to another leading to heritable changes in gene expression across generations however our understanding of paramutation in natural animal populations remains limited with most evidence coming from laboratory models this knowledge gap hinders our understanding of the role of paramutation in naturehere we will study paramutation in different natural populations of drosophila melanogaster to investigate its potential to drive transgenerational epigenetic inheritance and gene expression variation that can shape evolution we will investigate the responsiveness of paramutation to environmental changes and its heritable stability across generations we will also establish a model to dissect the molecular mechanisms of paramutation regulation assessing the role of insulator proteins such as suhw and 3d chromatin conformation this project will provide a comprehensive investigation of the role of paramutation in natural animal populations at multiple levels of information including genetics epigenetics gene expression and 3d chromatin structurethis research proposal aims not only to determine the biological relevance of a case of transgenerational epigenetic inheritance such as paramutation in natural animal populations but more importantly to provide an excellent model system for its indepth molecular dissection
inland waters in the digital twin ocean

ideation inland waters in the digital twin ocean aims to prepare the development of the digital twin of the inland waters rivers lakes reservoirs wetlands snow and ice addressing activities to be developed and to make it integrated and interoperable with the dto for a unified digital twin of ocean and waters addressing the hydrosphere as a wholeideation will be based on a crossborder cooperation involvement and commitment of stakeholders at european level by following the wateroriented living labs wolls approach stakeholders will be engaged via multistakeholder forums msf using a range of different engagement methodologies eg focus groups workshops interviews questionnaires depending on goals of the engagement and specificities of the context a comprehensive review will be performed to make an open knowledge inventory for inland water systems openkiwas ideation will codesign the ideation reference architecture defining a set of building blocks interfaces and standards to make data models and technologies interoperable and integrable with the dto putting together all the results from the msf openkiwas and the ideation reference architecture a roadmap for the integration of inland waters in the digital twin ocean will be created providing a preliminary breakdown of the work with priorities of implementation into a stepped approach the consortium members have high experience on eu project coordination and participation the majority of them already worked together in research projects
mission possible researchers on board for an inclusive and sustainable future

the vision of mission possible proposal is to connect researchers with citizens and the general public at large in a quest to increase awareness on research and innovation ri and their impact on citizens daily life and to boost public recognition of science and research education in cyprus in line with the call objectives mission possible will seek to bring researchers closer to the younger generation to engage inspire and encourage young people especially those who are less inclined to embark on steam science technology engineering arts and mathematics and research careers whilst supporting educators in developing a scientific approach through direct interaction with researchers in the framework of the proposed project two european researchers night ern events will be organised in cyprus on the last friday of september 2024 and 2025 accompanied by related pre and post events and activities such as open lab daysscience roadshows panel discussions and training workshops close to the dates of the ern events and complemented by the researchers at schools activities taking place all year roundthe main theme of the proposed project activities mission possible is inspired by the eu missions aiming to mobilise collective efforts to tackle common challenges by 2030 and bring about lasting impact the target audience is the public at large attracting people regardless of their age gender or scientific background with a special focus on families pupils and studentshaving coordinated the organisation of ern events in cyprus since 2006 the research and innovation foundation will seek to build on its accumulated experience and established collaboration with stakeholders of the local ri ecosystem to ensure success of project activities supported by a vibrant and diverse awareness campaign to communicate key project messages as well as by robust impact assessment activities
advancing european industrial sustainability and competitiveness through circular design strategies digital product passports and sustainable productservice systems in the furniture sector

the cir4fun project endeavours to transform the furniture industry by championing circular economy principles across the product life cycle through innovative strategies dpp and digital solutions supporting mechanisms it aims to enhance furniture sustainability ecolabelling and consumer engagement while aligning with relevant regulations and initiatives cir4funs approach involves creating a comprehensive circular economy roadmap defining content for a furniture dpp developing circular business models and ecodesign guidelines and establishing new assessment methodologies for maintenance reparability refurbishment remanufacturing and recyclability all this knowledge will be integrated in a holistic furniture assessment system fas including a sustainable index system dlca lcc slca fas will support the furniture ecoscoring system and dpp additionally it focuses on interoperability data sharing and data management with reliable approaches to enable simulation testing to inform supply chain strategies and extend product lifespan social engagement with stakeholders is emphasized to promote sustainable behaviours and circular practices ultimately supporting new regulations and standardization in the furniture industry the project outcomes will be implemented and validated in 3 use cases addressing different value chains across europe and the findings will be widely circulated across the furniture ecosystem in europe