Dragon09/odtu_chatbot huggingface dataset:
scalable unified processor enhancing revolutionary computing harnessing integrated performance for edge ai autonomous driving generative ai and decentralized aiot applications

the exponential increase in sensor data combined with artificial intelligence ai to support extensive and complex automation requires realtime supercomputing which todays semiconductor providers struggle to keep up withwe have developed a patented companion chip for ai and digital signal processing dsp tyr to create a paradigm shift in contextaware processing and transform industries such as autonomous driving ad and the ai of things this awardwinning technology has exceptional processing power and high implementation efficiency while consuming low power and costad our beachhead market is a perfect illustration of data availability and processing limitations there is currently no commercially and technologically viable solution that allows high full autonomy at level 45 therefore we have focused our product development on the global ambition to create l45 ad enabling realtime processing of all data to ensure 100 safety of the vehicle environment
setting baseline for a pcp heightening innovation procurements in the european security ecosystem and leveraging synergies through dissemination activities for crowd management

shield4crowd focuses on enhancing the protection of public spaces in eu cities against security threats related to crowd management public spaces are indeed largely exposed to several threats like uav and ugv attacks cbrn attacks cold weapons firearms attacks or urban riots and gatherings are by themselves a potential target for terrorist or criminal attacks this focus is shared from the start by several actors and specifically by security practitioners 3 ministries of interior from 3 eu countries 1 public transport operator and 2 security practitioners from poland and slovakia are thus involved as full partners many other endusers will also be involved through the user observatory group uog and some of them have already expressed official interest for the project shield4crowd implements a progressive and iterative process to jointly define one common challenge that can be tackled with identified candidate technology serving the basis for future pcp for which the buyers group will be created during the project through the continuous involvement of the uog first 10 jointly defined common security use cases will fully describe the gaps between available solutions existing processes and identified needs a technological analysis of those needs will then be conducted by technological experts including exploration of legal societal ethical and environmental considerations to allow the end users to converge to 3 uses cases from which a sota analysis and 4 open market consultations will be conducted all the results will finally serve to the definition of the common challenge and the elaboration of the first set of tender documentation shield4crowd includes a security advisory board to manage the sensitive knowledge generated by its activities and several advisors to guide the elaboration of a common challenge fully compliant with europes privacy and data protection regulations
unravelling the complexity of the reionization history though simulations and multiwavelength observations

the epoch of reionization marks the last major transition of the universe approximately 400000 year after the big bang the neutral intergalactic medium mainly composed of hydrogen atoms started to be ionized by highenergy radiation from the first cosmic sources stars galaxies the onset timeline and topology of the reionization process are all tightly linked to the nature of the sources of ionizing radiation by identifying and studying them we can gain fundamental insights into what shaped the evolution of the universe from the smooth matter distribution of early times as revealed by the cmb to the wealth of structures like galaxies and clusters of galaxies that formed at later epochs our project will exploit the critical synergies in expertise of the 4 pis and their teams from the modeling of the intergalactic medium ionization and metal enrichment to detailed observations of the ionizing sources to shed light on their properties their environment and the complex energy and baryon exchange between them and the intergalactic medium we will exploit new extensive datasets coming from stateoftheart facilities such as the recently launched jwst present and future vlt instrumentation and alma to support and drive the interpretation of these new observations we will develop a novel algorithm to model a selfconsistent nonequilibrium 3d multifrequency radiative transfer through h he metals and dust and produce both large scale and zoomedin simulations that can be readily compared to real data the proposed research aims at making fundamental steps to decode the mysteries of cosmic dawn and solve some of the puzzles in our current theories of early galaxy formation
a groundbreaking route via green methanol towards highefficiency local energy supply

the resme2e project aims to revolutionize smallscale green energy production by developing systems for generating green methanol from biogenic residues and converting this synthetic fuel into electricity using a highly efficient brayton cycle this approach challenges existing solutions by significantly enhancing the efficiency of renewable distributed energy and renewable fuel production at its core the project innovates in biomass waste gasification by combining oxygen gasification with plasma steam this method lays the groundwork for more efficient green methanol production a pivotal component in the projects vision a key aspect involves developing technologies for purifying syngas ensuring higher quality fuel production the project also aims to break new ground in electricity generation employing an air brayton cycle with heat regeneration and the mild combustion method which is expected to surpass the efficiency of classical systems these efforts converge to achieve an efficiency level twice that of commonly used smallscale orc systems marking a significant leap forward in sustainable energy technology the project integrates various scientific disciplines employing both experimental and computational methods it will tackle challenges like optimizing particle separators developing effective combustion methods and designing thermally efficient hightemperature heat exchangers the projects innovative approach also involves studying the interactions between different types of waste and their processing potentially creating new branches in thermal and plasma chemistry resme2es interdisciplinary nature and comprehensive analysis from microscale effects in dust separation to systemwide analyses position it at the forefront of renewable energy research the project aligns with the eus sustainable energy goals by promoting energy independence and ecological forms of energy contributing to the eus aims for sustainable development
disaster distortion climate crisis representation in contemporary transpacific literature

i explore how the representation of disasters in contemporary fiction warps our understanding of the threat posed by the climate emergency to do so i coin the term disaster distortion disaster distortion refers to how catastrophes monopolize the imagination when representing the consequences of climate alterations in ways that restrain or omit other forms of violence associated with human involvement and which are systemic stretch over longer periods of time and affect the most disenfranchised i focus on two ways for fictional disasters to produce this distortion first disaster dystopias promotes the idea that the climate emergency is a hypothetical concern and not a pressing issue second disasters estranges and alienates human agency and responsibility and exclude acts of interpersonal or environmental carein this project i propose to study the challenges of climate crisis representation by fashioning an exercise of comparative literature that explores the deployment of the trope of disasters in fiction produced across the pacific from the second decade of the twentyfirst century onward i choose to focus on three literary hubs distributed across this space japan australia and mexico i will select a corpus of up to 12 contemporary novels or anthologies of short stories 4 for each of the literary ecosystems the texts will be first analyzed using an interdisciplinary methodology that combines closereading with qualitative data analysis to examine the mechanisms through which we are imagining the climate emergencymy goals are to devise a theoretical framework that can question the usefulness of the trope of disasters assess to what extent climate dystopias are rising to the challenge of representing the climate crisis effectively examine whether representations of interpersonal and environmental care foster a sense of agency and responsibility and implement a functional methodological model of multipolar transpacific comparative literature
drug delivery to the brain via choroid plexus targeting

cns disorders eg brain cancer and alzheimers disease are the most common debilitating and underserved diseases cns drugs have historically suffered from considerably lower success rates during development than those for noncns indications one of the major reasons is the presence of cns barriers including the bloodbrain bbb and bloodcerebrospinal fluid csf barrier these bloodbrain interfaces severely restrict the cerebral bioavailability of pharmaceutical compounds while numerous attempts have been done to find methods to efficiently shuttle compounds over the bbb less work has been done on bloodcsf crossershere i hypothesize that targeting the bloodcsf barrier at the choroid plexus chp is an attractive innovative and underexplored strategy to deliver therapeutics to the brain indeed this cns barrier forms a unique interface between blood and csf and delivery of therapeutics across the chp epithelial cells may offer addedvalue for the treatment of cns diseases recently we could show that the bloodcsf barrier via hijacking the folr1 pathway is indeed a novel and exciting entry site to deliver therapeutics to the brain proof of concept data convincingly show that our in house generated antifolr1 single domain antibody vhh is able to deliver a peptide into the brain undoubtfully further validating the use of this vhh as brain shuttle could have major therapeutic implications here i aim to investigate 1 which cargos can be shuttled into specific regions of the brain 2 which neurological disorders might be targeted and 3 whether other rmt targets at the bloodcsf barrier have similar brain targeting capacitythis project will finally reveal whether the bloodcsf barrier is an interesting entry route to the brain with therapeutic potential consequently i infer that the data generated from this project may provide major impetus to the development of novel therapeutic strategies for the treatment of cns diseases
soft magnetic exoskin transducing human motion

wearable robotics is undergoing a disruptive transition from rigid exoskeletons to lightweight soft roboticexosuits which have achieved remarkable results in human motor assistance and augmentation these deviceshowever still lack intuitive control approaches imposing additional cognitive load on their users a futurewearable robot that can help us to walk run jump dance and restore independence in people with neuromuscularimpairments requires the key ingredient to achieve the symbiotic connection between the user and the robot in theclassical control strategy for wearable robots inertial measurement units imus are often exploited to detectusers motion intention although the latter are valuable wearable tools their reliability and accuracy are oftendebated due to their drift and poor battery life being powered raising challenges for researchers and engineers toimprove their stability over time the scout project aims to break this technological bottleneck by developing anovel wearable artificial sensor system based on passive magnetic markers to detect human motioninspired by the natural human sensorimotor system and exploiting recent advances in magnets localization a softmagnetic exoskin will be designed to transduce joints motion of the user into decipherable magnetic fields thesewill be decoded by a central interpreting unit to have a realtime reliable and robust measure of human kinematicswithout the need of timeconsuming parameter tuning and calibrations besides the intended benefit for currentwearable robots this project could develop a novel humanmachine interface with wide potential for a diverserange of applications such as human motion analysis ergonomics virtual reality and robotic teleoperation
epigenetic pathways of socioeconomic disparities across the lifespan

children who grow up in lowincome homes are at risk for worse mental and physical health for their entire lives a phenomenon known as the long arm of childhood but understanding and intervening on this process is enormously difficult as the effects of childhood environments can take decades to become visible in adult morbidity and mortality what researchers need is a wormhole ie a passage through time that connects childhood and adulthood in the proposed research project i will examine the utility of dnamethylation dnam as a molecular wormhole for investigating how socioeconomic disadvantage in childhood is linked with mentalhealth across the lifespan the proposed epigenetic pathways of socioeconomic disparities across the lifespan episodi project allows me to conduct my independent research project with leading scientists at the max planck institute in berlin building on the babys first years study n850 i will for the first time integrate methylation profile scores mps into a randomized controlled trial testing whether unconditional cash transfers to lowincome mothers for the first 4 years of the childs life cause changes in the childs methylome in early childhood additionally i will travel forward through the wormhole by developing mpss that index the socioeconomic conditions of childhood and testing their associations with mental and physical health in older adulthood health and retirement study n 4018 this will generate important and novel insights in the way social inequality shape differential outcomes in mental health across the lifespan throughout my research i have sought to bridge social and genetic science to better understand child development the project fits this aspiration and is an indispensable step in my career as it allows me to extend my current academic pursuits further grow into an independent researcher and help me to specialize in the exciting field of epigenetics
molecular mechanisms for construction of protective mucus hydrogels

our bodies produce copious mucus daily to shield vulnerable epithelial cell surfaces in the lungs intestines and other organs mucus is crucial for defense against pathogens and other environmental hazards but the mechanisms by which mucus hydrogels assemble and execute their functions are poorly understood the main obstacle has been that the enormous heavily glycosylated and flexible mucin proteins constituting mucus are not readily amenable to structural and molecular approaches however i contend that mucin glycoproteins have exquisitely specific abilities and interactions that are ultimately understandable on the molecular level by carrying out the research plan described herein we will crack the code that transforms the primary building blocks of mucins into diverse threedimensional dynamic and active hydrogels specifically we will test the hypothesis that glycosylated mucin regions are tunable entropic spacers that influence the positioning and adhesion of neighboring folded domains thereby controlling mucin assembly and hydrogel formation we will solve the first highresolution structures of respiratory mucins and will develop an experimental and theoretical framework for analyzing the spans and dynamics of oglycosylated mucin domains perhaps most exciting is our recent discovery that the redox setpoint of the golgi apparatus influences sialic acid decoration of oglycans during mucus biosynthesis with potential implications for mucus biophysics and viral penetration we will explore the benefits of this regulatory pathway for mucin selfassembly hydrogel properties and mucus barrier function together this work will pave the way toward rationally manipulating mucus hydrogels offering new avenues for the treatment of inflammatory fibrotic and infectious diseases
computing nonlinear functions over communication networks

sensibilit describes a novel theory for distributed computing of nonlinear functions over communication networks motivated by the longlasting open challenge to invent technologies that scale with the network size this intriguing and farreaching theory elevates distributed encoding and joint decoding of information sources to the critical network computing problem for a class of network topologies and a class of nonlinear functions of dependent sources our theory will elevate distributed communication to the realm of distributed computation of any function over any networkoverall this problem requires communicating correlated messages over a network coding distributed sources for computation of functions and meeting the desired fidelity given a distortion criterion for the given function in such a scenario the classical separation theorem of claude shannon which modularizes the design of source and channel codes to achieve the capacity of communication channels is in general inapplicablesensibilit envisions a networked computation framework for nonlinear functions it will use the structural information of the sources and the decomposition of nonlinear functions for efficient distributed compression algorithms for scalability it will design message sets that are oblivious to the protocol information for parsimonious representations across networks it will grip the curious tradeoff between quantization and compression of functions sensibilit has a contemporary vision of networkdriven functional compression via accounting for the description length and time complexities towards alleviating largescale realworld networks of the future the advanced theory will be tested in a reallife setting on applications of grand societal impact such as overtheair computing for the internetofthings massive data compression for computational imaging and zeroerror computation for realtime holographic communications
european laboratories for accelerator based science

nuclear and high energy physics explore at different scales what the universe is composed of and how it functions breakthroughs in accelerator and detector technologies combined with innovative experiments represent the key to new discoveries high energy physics while preparing for the hllhc is pursuing the design of the next generation particle accelerators and detectors balancing the present and the future newly available beams of nuclei far from stability and intense stable beams have opened new avenues ranging from the production of new elements to the exploration of nuclear properties at extremes of temperature angular momentum and isospin it is of vital importance to simultaneously optimize the use of existing and new research infrastructures ris to conduct curiositydriven research addressing fundamental questions and technological challenges and also advance projects with broad societal impact this project provides efficient access to the available resources to a large fraction of european laboratories for accelerator based sciences eurolabs it allows the diverse community of users to choose the best stateoftheart ri or a network of ris to conduct high impact research fostering knowledge sharing across scientific fields the proposal brings together for the first time the three communities engaged in nuclear physics accelerator and detector technology for high energy physics pioneering a super community of subatomic researchers it allows a synergic implementation of best practices for data management and activities relating to targeted service improvements at these ris joint training activities are foreseen to develop the skills of the next generation researchers to optimally use the ris services for scientific and technological discoveries eurolabs will create synergies and collaborations between the ris of the nuclear and high energy communities enhancing europes potential for successfully facing future challenges
commercialisation of a novel protein variant with neurorestorative effects for amyotrophic lateral sclerosis

regenera will assess the technical and commercial feasibility of a novel and optimised cmanf peptide as a superior treatment for amyotrophic lateral sclerosis als als is a fatal neurodegenerative disease affecting 450000 people worldwide where motoneurons mns selectively degenerate in the brain and spinal cord als is characterised by muscle deterioration that rapidly leads to disability and culminates in death 35 years after diagnosis unfortunately there is no cure for als and current treatments only marginally slow down its progression moreover promising neurotrophic factors ntfs with neuroprotective activity show insufficient efficiency are unable to reach the brain tissue and have highly invasive administration routes ie brain injections and intrathecal and high production costs as a result all ntfs clinical trials have failed ass prof voutilainen has discovered cmanf a novel peptide which in contrast to classical ntfs i has protective and restorative effects on motoneurons ii penetrates the bloodbrain barrier bbb iii can be subcutaneously administered and iv can be inexpensively produced within regenera we will assess whether cmanf is feasible as an earlytherapy option for als firstly we will analyse the pharmacokinetic properties and efficacy of cmanf in als animal models and in human mns subsequently commercial feasibility will be determined by verifying ip position and strategy performing indepth market and competitor analyses and finally consolidating these into a business case to establish the best path to commercialisation successful commercialisation of cmanf could reduce the profound socioeconomic burden of als provide an earlytherapy option to delay disease progression and thus extend and improve the patients lives and provide the pharmaceutical industry with a novel therapeutic that can potentially be used for other neurodegenerative diseases