Dragon09/odtu_chatbot huggingface dataset:
elevating the future of cancer care with alpha theranostics

accelerateeu a collaborative european initiative envisions revolutionising theranostics through innovative targeted alphatherapies tats using astatine211 a unique consortium will combine diagnostics with potent cytotoxic effects of alphaparticles to enable precise tumour radiation while minimising side effects accelerateeus core objectives areinnovate theranostic solutions based on therapeutic and diagnostic pairs for hardtotreat cancers exploring the potential for simultaneous preclinical studies and earlyphase clinical trials ie coclinical approach to showcase the enhanced benefits of these approaches for cancer patientsestablish a robust and sustainable eu manufacturing and treatment infrastructure for astatine211 ensuring compliance with quality assurance and regulatory guidelines while streamlining the supply chain across the euproduce comprehensive educational and training content to support the deployment of theranostic solutions fostering knowledge dissemination transfer and longevitydurabilityaccelerateeu strategically develop tats to address unmet clinical needs in pancreatic breast and brain cancers the coclinical approach incorporating concurrent clinical and preclinical studies adds a breakthrough dimension to theranostics accelerateeu pioneers 211attheranostics establishing a resilient eu scaleup production network and empowering healthcare providers to offer tats to cancer patients through the collaboration of experts from academia industry and regulatory agencies accelerateeus implements a visionary approach addressing clinical gaps accelerating tat theranostic development supporting eu global leadership with primary target to improve patient outcomes for lasting impact on eu cancer care
diverse exoplanet redox state estimations

new observational capabilities with the jwst and ariel space telescopes will strongly advance our ability to characterize exoplanetary atmospheres while the community focusses mainly on biosignatures in diverse i will search for signatures of geophysical factors that influence habitability specifically the diversity of planetary redox states the redox state is of major importance for habitability since reducing conditions favour prebiotic chemistry for life as we know it atmospheres of rocky planets are typically divided into two distinct classes h2hedominated reduced atmospheres of primordial origin here denoted as class i planets or secondary more oxidized atmospheres of volcanic origin here named class ii planets in the solar system observations are limited to old evolved atmospheres that became oxidized over time and do not allow to directly constrain the planets interior redox states furthermore detection of reduced species such as co or ch4 does not unambiguously link back to the interior redox statein contrast if we were able to detect h2dominated atmospheres lacking he here called class x planets the most likely explanation would be strongly reduced degassing from the magma ocean or subsequent volcanism distinguishing class i and x planets would truly allow to constrain the planetary redox state and indicate how it depends on observables such as stellar composition or planetary mass estimates on the distribution and observability of class x planets are yet missing but became recently possible diverse will build strong predictive theoretical models linking the interior evolution including core formation with atmospheric abundance and erosion models including the observability potential to determine the diverse evolution pathways of reducing atmospheres of primary secondary or hybrid origin i will thus address whether and for which planet classes the atmosphere could indeed serve as a window into the interior
unifying ecophysiological predictions of ectotherms to global warming

ongoing climate change represents a major threat to biodiversity and scientists now face pressing concerns to forecast how ecological communities will respond to global warming in the medium to longterm however the current framework to study heat tolerance rely on critical thermal limits ctmax which comprises a coarse metric that has been shown to be unrealistic not only results from ctmax are ludicrous they do not allow for temporal forecast unfortunately this is what overwhelming majority of research groups are now measuring at an enormous waste of time and human effort the ewarm project proposes the ambitious umbrella objective of stablishing a unified predictive framework for the study of heat tolerance in terrestrial and aquatic ectothermic animals for this purpose the candidate will develop a novel comprehensive analytical toolbox to anticipate heat mortality with a unprecedented accuracy and reliability this approach translates highresolution temperature records from the field into realistic mortality rates of species importantly the analytical routines proposed can be expanded to include the interplay of warming with other factors such as heat waves phenotypic plasticity or hypoxic stress as a proof of concept the candidate will study drosophila species as model organisms from terrestrial and daphnia species invertebrate and galaxias maculatus fish as model organisms from aquatic ecosystems the subject of the ewarm project is both timely and important as more reliable predictions of the impact of global warming on populations resilience are urgently needed repercussions of this research will be immediately transmitted to the society and they will have a big scientific political economic and health impact
global governance of labour an integrated approach

the project global governance of labour an integrated approach glogolab aims to investigate in a comprehensive way the emergence of different transnational regimes of regulation of work in response to the increased integration of the world economy the project uses a msca global fellowship to leverage on my expertise on multilevel economic governance industrial relations and labour sociology and bring it from a continental to an even more relevant global level it will be hosted by the department of political and social sciences at scuola normale superiore under the supervision of prof guglielmo meardi who is a leading scholar in the field of labour sociology and industrial relations and by the ilr school at cornell university in the us host of outgoing phase under the supervision of prof sarosh kuruvilla worldrenowned scholar of employment relations in global supply chains the action has three specific research objectives first to provide a comprehensive mapping of different forms of global governance of labour emerged with the increased transnationalisation of the world economy building a database covering the last three decades 19902020 ro1second to analyse and compare the impact on workers rights of different global labour governance structures and the different strategies adopted by social forces visvis them through an indepth comparative analysis of four critical cases drawn from the database ro2third drawing from different theoretical approaches industrial relations multilevel governance social movement studies to refine an analytical approach which is able to account for the complex policy processes and outcomes taking place within global governance of labour structures ro3 by proposing an integrated approach to the study of global governance of labour the project will therefore make a significant empirical and theoretical contribution
subtype as a key to reduce heterogeneity of treatment effects in major depressive disorder

major depressive disorder mdd is a leading contributor to disability and suicide it is the most costly brain disorder in europe although multiple treatments are of proven efficacy individual responses to treatments vary considerably and mdd recurrence is common there is considerable motivation to improve treatment regimen for individuals with mdd however it has been challenging because of the fundamental lack of understanding about the causes of variable treatment outcomes mdd is widely accepted as a heterogeneous disorder yet most research strategies effectively consider mdd as a single disorder progress in understanding the variable treatment response will depend on patient stratification ie identifying and accounting for patient heterogeneity when evaluating treatment efficacysubtreat proposes a unique direction which considers subtype as the key to link aetiological and treatment effect heterogeneity our approach is to break down the heterogeneous treatment outcomes of mdd into more narrowly defined subtypes with divergent aetiologies specially i propose three work packages 1 dissect treatment heterogeneity across subtypes a particularly innovative aspect of subtreat is that we will use advanced data science approaches to identify novel subtypes which correlate with differential treatment outcomes 2 determine divergent causes underlying mdd subtypes we will comprehensively investigate causes at three levels including genetic and causal epidemiological risk factors and brain cell types 3 develop a novel prediction algorithm for treatment outcomes stratified by patient subgroups subtreat will illuminate the causes of mdd subtypes and the principal patterns of how subtypes contribute to differential longterm treatment outcomes subtreat findings will promote targeted drug development and treatment optimization for patient subgroups to achieve precision psychiatry
conjugation of nadcapped rnas to proteins by adpribosyltransferases to generate rna therapeutics

background we discovered that nadcapped rnas can be covalently attached to specific target proteins by the phage t4 adpribosyltransferase art modb which we term rnaylationscientific problem rna therapy has almost limitless yet unexplored potential its translation into the clinics however requires optimal rna delivery with high rna stability efficient cellular internalisation and precise target affinity hypothesis proteinrna interactions are ubiquitous and central in biological control i hypothesise that conjugating a nadcapped nucleic acid to a protein catalysed by an art generates a novel biomolecule the rnaylated protein with unique functionalities the covalently linked protein or nucleic acid can trigger a directed intracellular delivery where both the protein and the nucleic acid can become functionally active this allows targeted modulation of translation or transcription or editing rnaylated proteins may provide a platform to engineer the cell and represent a starting point for the creation of next generation rna therapeuticsobjectivesthis project aims to establish rnaylated proteins as a fundamentally novel tool to regulate cellular processes in objective 1 we will define the design principles for rnaylated proteins allowing to control cellular processes in objective 2 we will develop delivery strategies to transfer rnaylated proteins in specific cell types and allow for precise cellular localisation in objective 3 we will combine the design and delivery principles for rnaylated proteins and apply them to target the tumour suppressor protein p53 by regulating translation transcription or by editingimpact this project will develop rnaylated proteins as next generation rna therapeutics and deepen our understanding of how a fundamental scientific discovery the rnaylation of proteins catalysed by the t4 art modb can be translated into an application
a groundbreaking collaboration framework realizing the next era of cybercrime detection and multistakeholder investigation for leas judicial ecosystems and citizens

in order to address the fastevolving challenges with respect to advanced forms of cybercrimes enabled by fully available stateoftheart technologies crimeasaservice there is a need for leas to form and apply cuttingedge collaboration frameworks that will break communication silos within the wider judicial ecosystem these frameworks may span in numerous pillars such as i regulated privacypreserving and easy sharing of information related to criminal activities enabling crossborder agencytoagency collaboration in a transparent and explainable manner ii joint criminal investigation further facilitated by beyond stateoftheart tools enabling realtime collaboration and the full exploitation of distributed digital infrastructures to enhance cybercrime intelligence iii exchanging different types of expertise cybersecurity experts forensics experts lawyers and stakeholders from the judicial ecosystem psychologists social scientists to realise cutting edge investigative approaches and iv knowledge and best practices sharing with respect to trainings and cybercrime awareness ganndalf will set new grounds for the fight against advanced forms of cyber threats and cyberdependent crimes it will i realise cuttingedge agencytoagency data sharing mechanisms optimising the balance between transparency and privacy based on the needs of each lea ii deploy a modular decisionsupport toolbox that will comprise not only groundbreaking technologies for collaborative investigation prediction and identification of advanced forms of cyber threats but also optimisation mechanisms enabling the full exploitation of these technologies iii build on the above 2 offerings and deliver a customizable collaborative crime investigation sandbox for scenarios hypotheses analysis and crime investigation and iv facilitate policy drafting training and citizens engagement via innovative mechanisms that will realise the cyber hygiene 20 visin
future data storage using colloidal memory technology

data is being generated at everincreasing rates with the widespread digital transformation in businesses and society the continually increasing demand for affordable data storage puts tremendous pressure on storage technologies new concepts for lowcost highstoragedensity memories are urgently needed to keep storage capabilities in line with the growing demand fastcomet is a colloidal memory concept in which colloidal nanoparticles are considered data carriers the memory consists of a large array of nanocapillaries in which two types of nanoparticles with antagonistic electrophoresis dep properties can be selectively inserted into the capillary by dep forces data can be stored as the specific stacking sequence of the different particle types a cmos circuit at the periphery of the array addresses and controls the electrodes the longterm aim is to develop an integrated device that is able to store data using nanoparticles smaller than 15 nm this would ultimately result in ultrahigh bit densities exceeding 100 gbit per square millimeter and potentially reaching 1 tbit square millimeter at a lower cost than existing data storage technologies in the fastcomet project we aim to establish a proofofconcept for colloidal memory by identifying suitable nanoparticles developing nanofabricated test structures using advanced nanoscopy imaging techniques to demonstrate the selective manipulation of nanoparticles into passive nanocapillary arrays and establishing a modeling framework for future technology development
exploring the impact of anisotropic viscosity on the interplay between ice and mantle dynamics

the loss of ice mass from polar and highelevation regions is a significant contributor to global sea level rise and affects climate and biosphere changes due to its importance a better understanding of the dynamics of ice sheets is considered a priority for scientific advancement by the intergovernmental panel on climate change dynamice aims to enhance our understanding of ice sheet dynamics and ice mass loss by investigating the coupled flow dynamics of polar ice and the deforming mantle below with a focus on the role of anisotropic viscosity for determining deformation ratesice and olivine the main building crystals of ice sheets and the mantle respectively are two of the most anisotropic crystals on earth this means that individual crystals have preferred slip systems along which it is easier to deform them depending on the deformation direction with respect to the mean orientation of crystals in both ice and mantle rock the bulk viscosity can vary by a few orders of magnitude such variations in viscosity can greatly affect the flow of ice from ice divides to the sea as well as the mantles viscous response to the unloading of deglaciated ice as a result spatial differences in ice texture can locally enhance or slow down ice flow leading to some areas with faster than average ice loss and others where ice is stabilized moreover in locations where ice loss is fast and where mantle textures are favourably oriented the viscous response of the mantle can be fast enough to uplift the ice and slow further ice loss potentially stabilizing the ice sheet hence anisotropic viscosity might play a critical role in the interplay between ice and mantle dynamics in dynamice i will implement a framework to infer anisotropic viscosity from both ice and mantle textures in a numerical flow model this will open new avenues for understanding solid earth and cryospheric dynamics and their critical interactions that affect the future of earths ice sheets
copying as common practice in early modern architecture

this project advances the hypothesis that techniques of mechanical drawing and specifically drawings produced by manual copying and direct tracing served as the bedrock of early modern architectural education prior to the advent of formal schools of architecture the normative histories of fifteenth and sixteenthcentury italian architecture have relegated drawings of mechanical subject matter construction machinery scaffolding systems structural diagrams military devices to a lower nonartistic status these drawings are deemed inferior not only due to their subject matter but also due to their ubiquity the mechanical drawings used by early modern architects were widely circulated and routinely copied indeed copying drawings and traces have long been considered corrupt in the foundational discussions of disegno the practice and product of drawing giorgio vasari explicitly ridiculed copying practices and the infinite number of substandard artists who employ techniques of tracing in turn he celebrated drawings that were demonstratively autograph or individual as the embodiment of their creators singular genius this framework lay the foundation for modern historys critical assessment of drawings and cemented the idealization of early modern italys great architects while recent decades have seen a notable increase in research on techniques of copying and tracing in the study of early modern painting there remains a critical absence of scholarship that examines the derivative practices that underscored early modern architecture looking beyond anachronistic conceptions of art architecture and engineering and examining a broader corpus of early modern architectural drawings identifying images that are formally and technically related in their execution the project investigates the intellectual processes of design training and brings to light the collaborative frameworks of architectural production
long life power platforms for internet of things

in lolipop iot innovative long life power platforms will be developed to enable retrofitting of wireless sensor network wsn modules in iot applications this includes the development of algorithms to perform functionalities like asset tracking and condition monitoring for predictive maintenance they can be used in applications such as industry 40 smart mobility and energy efficient buildings lolipop iot creates an ecosystem of developers integrators and users to develop these platforms thinking about powerbattery life ease of installation and maintenance the project is driven by 12 laboratory and fieldbased use cases to initially demonstrate their technical viability and then potential impact expected impacts from the lolipop iot use cases include a typical battery life increase from 18 months to 5 years b reduced maintenance overhead of mobile and fixed assets from 30 to 15 c reduced costs related to location of assets typ by 100ks pa per use case d optimised flow management and throughput of assets through the identification of bottlenecks yielding reductions of 10 in production time cycle time and inventory costs e improved comfort levels and wellbeing of building occupants whilst reducing energy footprint by 20 and f revenues of 10m pa for lolipop iot industry partners offering asset tracking condition monitoring services all of this is achieved by developing and integrating a multisource energy harvesting solutions vibrational and photovoltaic transducers pmics and discrete circuits b digital interfacing to contextually adapt mode settings of wsn devices and connected systems to minimise power drain c ultra low power components for wsn d innovative architectures for wireless data collection that minimize battery power drain e simulation models to optimise component design and integration and f embedded aiml in iot devices for lower latency and power consumption and higher robustness
multiorgan toxicity and efficacy test platform for personalized medicine drug development

the pharmaceutical and medical fields need more predictive models to assess the effects of drugs on patients the demand arisesfrom the desire to replace animal tests enhance predictability and reduce drug development time and costs in personalizedmedicine theres a need for tools like companion diagnostics to identify patients who will benefit and respond from specifictreatmentsrecent changes in eu and us regulations allowing drug candidates to be submitted without animal testing have led to thedevelopment of alternative solutions like 3d cell culture and organsonachip these technologies have shown promise in predictingdrug effects on patients but 3 scientific challenges persist namely including functional vascular interfaces multilayer tissueequivalent reconstruction without pdms and cultivating interconnected organs with varying oxygen concentrations also 2industrial bottlenecks on the compatibility with multiwell plate formats and the need for reproducible biological protocols arepresentcherry biotech has developed a 3d cell culture platform that addresses these bottlenecks with three innovations the microfluidicperfusion lid mpl the hydroflat and the cubix control unit these innovations have received approval from industrial and hospitalpartners and has been patented in europe and usthe company aims to address the preclinical drug development cubix ruo 2026 market and the precision medicine market cubixcdx 2030 the preclinical drug development market is growing rapidly due to favorable regulatory changes while the precisiononcology market is driven by biomarkerbased assays for guiding medical treatmentscherry biotechs work not only has financial implications but also has a significant impact on human health and animal welfare byoffering predictive models and reducing the need for animal testing it contributes to technological advancement and innovation inthe eu