Dragon09/odtu_chatbot huggingface dataset:
upright radiotherapy learning innovation fellowship and training

radiotherapy rt is a mainstay of modern cancer treatment conventionally rt is delivered to the patient lying on a treatment couch while a beam steering device gantry aims the radiation from any angle around the target positioning the patients in upright body posture uprt instead enables to orient the patient arbitrarily toward a fixed beam this enables smaller facility footprint and reduced treatment cost placing uprt in the core of the un sustainable development goals and opening global access to advanced treatment options 80 of cancer patients live in countries which host only 5 of the worlds rt resources moreover uprt improves patient comfort and is associated with anatomical and physiological advantages such as reduced breathing motion it therefore comes as no surprise that with new upright patient positioning imaging solutions entering the market uprt is enjoying a surge in interest yet key scientific questions remain international guidelines for uprt are lacking and existing rt workflows are geared to lying patients as the first clinics adopt new uprt technologies there is a global need for trained professionals in industry clinics and academia to reach the promised benefits for patient care uplift builds this next generation of experts by addressing key research questions related to treatment planning clinical workflow and equipment design leveraging latest uprt technology available through our worldclass consortium uplift propels europe to the forefront of the uprt paradigm shift uplift focuses on learning through its academic and clinical centres of excellence innovation through its leading industrial partners fellowship training through an outstanding crosssector programme of workshops secondments mentoring input from patient advocacy groups and an internationally renowned advisory board will maximise its impact uplift will revolutionize modern rt making it more human accessible and sustainable
transforming boron chemistry by exploring boryl radical reactivity

our ability to construct organic molecules is central to the wellbeing of our society boroncontaining compounds are some of the most used tools to aid this these materials are used as building blocks when stitching molecules together and also as catalysts in many different settings the invention of innovative strategies to prepare and exploit borylated molecules is integral to discover and manufacture many products that we use daily the overarching aim of this proposal is to innovate organic chemistry by inventing novel catalysis concepts based on the reactivity of boryl radicals an underutilized class of reactive intermediates my group has introduced a novel approach to generate these species from amineborane precursors and here i aim to1 establish a general platform to borylate aromatics using boryl radicals this blueprint for cb bond formation will introduce amineborane functionalities instead of standard boronic acidsesters this will provide unprecedented synthetic capacity because the amineborane will serve a dual role acting first as directing group for orthometa functionalization and then crosscoupling handle2 explore boryl radicals in innovative cascades reactions leading to the divergent assembly of sp3rich fragments these methods will expedite the preparation of polyfunctionalized materials tapping into unexplored areas of chemical space3 establish boryl radicals as hatom transfer catalysts to achieve the philicity umpolung of nucleophilic radicals this concept will introduce unprecedented retrosynthetic tactics and enable the merge of boryl radical reactivity with asymmetric organocatalysis overall this cohesive and innovative research plan offers the unique opportunity to discover novel and exciting transformations that go far beyond what currently possible achieving this project will provide unprecedented tools for the preparation and the use of borylated materials in synthesis and catalysis
empyrean trustworthy cognitive and aidriven collaborative associations of iot devices and edge resources for data processing

empyrean envisages a hyperdistributed computing paradigm based on federations of collaborative and heterogeneous iot devices and resources eg on riscv across different providers and networks these federations namely associations operate autonomously and interconnect seamlessly utilizing distributed cognitive and dynamic aienabled decisionmaking to balance computing tasks and data inside an association as well as between associations in a multiagent manner and across central computing environments optimizing resources and providing scalability resiliency energy efficiency and quality of service an association will constitute a trusted execution environment while identity and data access management schemes will assure controlled access and confidentiality of data utilizing cluster 3 related outcomes from participating partners empyrean will also be empowered with automated tools and mechanisms for efficient data processing of aiworkloads and secure distributed edge storage developed technologies will also enable associationsnative application development and deployment contributing to the entire application lifecycle and interoperability empyrean will provide open and standardized apis while utilizing and extending opensource platforms maintained by european companies from the consortium empyrean will demonstrate its advanced and innovative capabilities through three welldefined use cases that involve device and datarich applications in advanced manufacturing smart agriculture and warehouse automation involving aidriven value extraction from high volume and dynamic iot data generated by multiple sources eg robots at the edge of the network also a south korea based use case in smart factories will further showcase the benefits of the empyreans technologies empyrean will develop its associationbased continuum through synergies with emerging ipcei initiatives and eu bodies eg gaiax idsa by involved partners
whats wrong ancient corrections in greek papyri from egypt

this project aims to transform the study of the ancient greek language by shifting the focus away from famous literary authors towards the language as it was produced in everyday life the large corpus of 60000 greek texts written on papyrus between 300 bce and 800 ce provides an important source for our knowledge of the ancient world and offers an excellent opportunity to study the greek language as written by nonscholarly writers in antiquity in order to really change our views of what correct ancient greek should look like we need to take a different perspective the perspective of the ancient writer what did the writers perceive as a mistake how did they compose their texts in order to answer these questions this project employs an innovative resource the corrections made by the ancient writers themselves a multidisciplinary team of three researchers and a studentassistant will analyse scribal corrections at different levels of language production from spelling and morphology to semantics and phraseology across a range of different genres contracts petitions letters and lists with the following three key objectives1 to create an annotated openaccess relational database of ancient corrections in greek papyri2 to study the production of greek spelling from below as corrected by the ancient writers themselves comparatively in different genres written by writers from diverse backgrounds3 to identify the stage of composition of a textual object and make this category an integrated part of the analysis of historical textual artifacts such as papyrus documentsthis will give us a unique perspective at the greek language and allow us for the first time to study what is right and wrong in the postclassical greek language in daily practice the outcomes of this project will change how we perceive nonscholarly writers and thereby contribute to a new and more inclusive perspective on ancient societies
parasitehost interactions regulating dormancy and reactivation of malaria parasites

whathypnozoites are dormant liver stage malaria parasites that can reactivate and cause repeated bloodstage infections without the bite of an infectious mosquito we will for the first time characterize the cellular environment contributing to dormancy at systems level wp1 explore the reactivation kinetic and tissue environment of hypnozoites within the natural host wp2 functionally characterize host parasite factors governing dormancy or reactivation wp3why dormancy and reactivation of hypnozoites is an unresolved biological mystery since decades dormant parasites are a major obstacle to the curative treatment of malariathe challengetracking the in vivo development and understanding the biology of these rare quiescent parasites that normally reside inside the liver of the hostthe solutiona synergistic multidisciplinary investigation which is only possible if we combine the unique resources and complementary expertise of three leading laboratories in radiopharmaceutical chemistry for the development of dedicated positron emission tomography tracers for noninvasive investigation of the parasites in situ as well as to capture infected tissue samples for systems level investigations systems biology for simultaneous multiomics profiling of the parasite and the host cell at singlecell resolution and in the spatial context to be validated by parasitological assays parasitology for functional investigation through genetic engineering and manipulation of the parasites in vitro and validation within the natural hostanticipated project outcomes detailed insights into the relapse characteristics of the parasite in vivo understanding how host and parasite factors collectively determine the fate of infection novel imaging transfection and omics methods for malaria research and beyond opportunities for novel therapeutic strategies for awakening and killing these vicious pathogens
twinning for excellence in management and economics of research and innovation

the adoption of the new pact and governance for the european research area era that includes a new regime for open science endorsed by all eu27 competent ministers for ri the need for research integrity and a common set of principles and values to reaffirm solid foundations of ri ethics freedom of scientific research gender equality and equal opportunities the increased free circulation of researchers innovators and knowledge the cultural distance of ri consortia and the engagement of citizens in science and innovation and regional convergence in ri capacity are areas that need rigorous attention also the determinants of ri productivity the role and efficiency of ri funding and both experimental approaches and theoretical economic models that can enable better understanding of the interactions of different actors in a ri ecosystem are of utmost importance the twinning for excellence in management and economics of research and innovation twin4merit project aims to examine these metaresearch areas of critical importance by facilitating a partnership with two advanced partners in the field in order to advance all related research activities at the university of cyprus ucy this vision will be realised by applying for a horizon europetwinning grant in conjunction and under the aegis of the research and innovation service of ucy and the sinnopsis research unit for science and innovation policy and studies which is part of a secured h2020era chairs project by ucy this newly established research unit coupled with the new network of advanced partners of the twin4merit proposal um and uc3m will facilitate the gradual upgrade of the research activities in the field both in cyprus and internationally the research excellence of the advanced partners is of multiple focus and this will act favourably for ucy in developing a series of different skills in the field and for producing novel research output in the areas of interest
multiomicsbased biomarker signatures of dietary carbohydrates quality and risk of chronic diseases

the prevalence of type 2 diabetes mellitus t2d cardiovascular disease cvd and dementia is rapidly increasing worldwide and is therefore a major public health concern carbohydrate intake 4080 represents the main source of energy in most populations and the quality more than the quantity has a large effect on health recently a carbohydrate quality index cqi emerged as a exposure that captures the combined and potentially synergistic effects of dietary glycemic index and intakes of total fiber whole grains and liquid or solid carbohydrates in a comprehensive manner a high dietary carbohydrate quality assessed by the cqi has been associated with lower risk of t2d cvd and intermediate risk factors however the precise mechanisms of the associated beneficial effects offered by high cqi scores remain unresolved partially due to the lack of accurate biomarkers reflecting their exposure and the minimal information available on how cqi impacts the gut microbiota the main objective of biscuits is to identify multiomics signatures of dietary carbohydrate quality assessed by the cqi and evaluate their associations with the risk of chronic diseases in adult populations we will integrate metabolomics and microbiota datasets using novel machine learning algorithms to identify combined panels of metabolites and microbial species reflecting the exposure to high cqi scores we will also investigate the potential associations of these signatures with the risk of t2d cvd and dementia in two populations similar studies to this are not available in the literature and have the potential to discover novel biomarkers of cqi exposure and map biochemical mechanisms explaining the complex relationship between cqi and these diseases this could open new avenues for the prevention and management of cardiometabolic and neurodegenerative diseases resulting in easytofollow lifestyle recommendations and strategies that general population and patients can easily adopt
initiation factor 3 as target in cancer therapy

eukaryotic translation initiation is a process wherein ribosomal subunits are assembled by eukaryotic initiation factor eif proteins mammalian eukaryotic translation initiation factor 3 eif3 consisting of the 13 subunits eif3a to eif3m is the largest and most complex eif due to the emerging understanding of the role of eif3 in a wide range of cancers there is an increasing interest to examine its many subunits as potential therapeutic targets furthermore interactions between subunit eif3c and tumor suppressor protein schwannomin has been reported to promote development of the tumor neurofibromatosis 2 nf2 very few small molecule inhibitors reported targeting eif3 subunits are reported and are associated with high degree of uncertainty there is hence a need to develop new and highly effective small molecules targeting the eif3 subunits to be used in the treatment of cancer as well as in the fundamental understanding of the interactions between the various subunitsthe aim of this interdisciplinary project is to investigate the structures dynamics and interactions of subunits in the eif3 family and use this information to design synthesize and test compounds for targeted cancer therapy we will employ a range of computational and bioinformaticsbased tools proteinprotein docking molecular dynamics and metadynamics simulations machinelearning based ligand design and docking techniques to identify and explore key druggable interactions and regions in the initially targeted subunits eif3a and c to verify the inhibitory potential of the designed small molecules chemical synthesis and in vitro evaluation will be performed through the combination of computational modeling subunitspecific inhibition and measurements of anticancer activity we will be able to understand in more detail the mechanisms of action as well as interplay between different subunits and the interactions between eif3c and tumor suppressor protein schwannomin
understanding diversity in decision strategy from neural circuits to behavior

the brain has the remarkable ability to imagine diverse solutions to complex problems and to rapidly switch between them to adapt to new situations such properties are essential for adaptive behavior but remain poorly understood partly due to the prevalent focus in previous studies on stereotypical behaviors here we will adopt a fundamentally different approach by exploring the neural properties underlying diversity in decision strategy aiming to provide greater insights into how the brain operates in natural conditionsby leveraging novel computational methods that identify changes in behavioral strategy combined with the latest advances in electrophysiological recording and optical manipulation in mice the overarching goal of the project is to understand how the brain switches between different decision strategies we hypothesize that the brain achieves remarkable flexibility by running multiple decision processes in parallel allowing animals to select one decision strategy while their brains maintain several alternative solutions readily available for quick adaptation we will test this hypothesis through a series of experiments that aim at determining1 which neural circuits are involved in strategy selection2 what neural mechanisms control changes in strategy3 how to trigger a strategy in neural circuits and behaviorswe will address these questions using mice in the context of foraging a fundamental survival behavior shared among all animals involving the search for resources in dynamic environments the project will deliver a rich and unique neural and behavioral dataset enabling the development of a novel conceptual framework for behavioral flexibility as an adaptive selection mechanism of parallel decision computations ultimately this research will contribute to solving various aspects of the decisionmaking puzzle and provide a foundation for explaining the diversity in behaviors including those that deviate from the norm
hypertargeting car nk cells from induced pluripotent stem cells for novel offtheshelf antitumor therapies

the hypertargipsnk project aims to combine novel technologies from three research laboratories and a stem cell company to develop a revolutionary therapeutic modality for patients with devastating refractory malignancies the treatment we propose is based on allogenic transplantation of induced pluripotent stem ips cellderived natural killer nk cells genetically modified to a hyperactive state to ensure high potency nk cell targeting and destruction of tumor cells car nkbased cancer treatment is an extremely promising new therapeutic avenue however the full potential of car nk therapies will only be achieved when an offtheshelf product is rapidly accessible to patients in need ips with its unlimited expansion potential is the ideal cell source for nkbased products however improved efficiencies of nk cell production suitably activated status and resistance to immune suppression would need to be achieved we have several breakthrough technologies to address these issues with 1 a novel ips cell differentiation system based on our newly identified metabolic regulators that can be easily scaled to generate billions of functional nk cells 2 identified and validated several novel and stateoftheart car noncar and truck based regulators of nk activation to elicit the hyper activated nk cell state and prolonging nk survival and 3 improved nk response to tumors via tumor microenvironment remodeling we will target the nk cells towards three lifethreatening cancers for which novel treatment options are urgently needed as they are considered among the most lethal cancers ie pancreatic cancer glioblastoma and acute myeloid leukemia aml our ips culture system nk activation systems and gene editing systems have already been designed towards gmp compatibility taken together these advances ensure that once this study is successful our hypertargipsnk cells are poised for rapid translation towards the clinic with our industrial partner
integration of underutilized ashes into material cycles by industryurban symbiosis

the incineration of biomass municipal solid waste and sewage sludge produces significant quantities of ashes in the eu approximately 25 million tons annually these residues have currently no use or they are utilized only in lowvalue applications major problems with the use of incineration residues in the construction water treatment and other industries are insufficient public awareness of the safety and environmental acceptability of the final products the lack of uniform regulations and readiness of the market to accept incineration residues as a supplementary material the project ashcycle will demonstrate and implement industryurban symbioses revolving around the underutilized ashes to reach circular and climate neutral economy in europe pilots and replication demonstrations will be carried out in denmark finland belgium the netherlands croatia slovenia switzerland and south africa the symbioses will include all major actors from the value chains namely ash providers ash beneficiation handlers concrete and adsorbent product providers as well as engagement of general public ashcycle answers unmet socioeconomic demands facilitates emerging ashbased circular products for market entry and to unlocks benefits for society by acceptance of new circular concepts
technology for 3d fibrous eco materials

we create eco fibrousmaterials alternative to fossilbased materialsfor the first time ever we are adding 3rd dimension to paper or textilelike materials we bond 3d structures from cellulose fibres while preserving environmentallyfriendly properties given by nature it allows to achieve 100 eco material with external shapes and internal densities which have not been possible yet our technology has been tested in eg thermalsound insulations packaging air filters the aggregated market opportunity is 700 bn we would not replace all current products and some applications of plastics can be ecologically valid postrecycling but many of these markets need to find eco alternatives a good example is use of lightweight cellulose 3d structures instead of difficult to recycle polystyrene in packagingthe first productmarket fit is biodegradable growing media soilless substrates for plant cultivations due to increase of investments in vertical farms in covid times