Dragon09/odtu_chatbot huggingface dataset:
knowledge based framework for extended textile circulation

the textended project will achieve its overall objective of reduction of textile waste by 80 by within industrialurbal symbiosis developing and demonstrating effective textile recovery waste valorisation and recycling processes combined with digital tools sensing systems and datadriven solutions to support sustainable circularity of textiles we will develop a knowledgebased blueprint ie a master plan for a sustainable textile ecosystem the basis of the blueprint is a conceptual framework which determines the optimized utilization of textile flows aiming for retention of value of materials in a safe and sustainable way based on the blueprint we will implement a real scale demonstrator verifying its replicability and potential to reduce textile waste textended brings together a multidisciplinary group of experts with complementary skills needed for twin transition in sustainable textile sector different types of organizations research industry and nonprofit organizations such as ngos and municipal waste management are included the consortium consists of actors with different roles in the textile recycling ecosystem waste management recycling textile materials and textile products manufacturing participation of forerunner companies and actors involved in textile recycling enables us also to spread best practises for textile recovery and recycling around europe and across the sector
photocatalytic reactions under light and dark with transient supramolecular assemblies

the efficient conversion of solar energy into molecular fuels has been recognized as one of the grand challenges facing society today this is motivated by the urgent need to develop affordable reliable sustainable modern energy as a way to address the problems arising from the burning of fossil fuels and global warming rapid progress is being made in the development of photocatalytic systems that use directly solar light to produce fuels but do so only during daylight this is a significant oversight as the overall processes are inefficient due to the intermittent nature of the solar energy source the next frontier in energy conversion and the key objective of my proposal are smart materials that perform photocatalysis under irradiation and in addition can trap and concentrate sunlight to then use it for catalysis under low or no illumination to achieve this ambitious goal tenebris aims to develop an unprecedented strategy to enable dark or persistent photocatalysis by using selfassembled materials tenebris will i provide missing insights into lightdriven supramolecular polymerization ii deliver smart autonomous and transient selfassembled materials that perform photocatalysis also under dark and iii establish design principles to be generally applicable for tailormade nanomaterials with functions unattainable through conventional methods the fundamental outcomes of this research will lead to nonincremental advances in various chemical research areas photocatalysis outofequilibrium supramolecular chemistry and materials science and engineering and to a substantial impact beyond them
novel gutstable peptides and drugdelivery systems possible treatment for ibd

inflammatory bowel diseases ibd affect more than 2 million residents in europe currently there is no cure for ibd and treatment focuses on alleviating symptoms injuredcompromised mucosal barrier and gi biofilms are common pathophysiological deviations in ibd the overall aim of this project is to develop gutstable peptides effective against biofilms peptides suitable for woundhealing treatment and nanocarrier systems for targeted delivery in particular i will focus on developing new antibiofilm peptides based on the existent cathelicidins and also develop gi woundhealing peptides based on the trefoil factor family tff cathelicidins and tff peptides occur naturally in humans and defects in these response systems can lead to gi diseases hence in this project i aim to i design synthesize and characterise novel gutstable antibiofilm and woundhealing peptides and ii develop nanoparticle drugdelivery systems for their targeted application based on peptidomimetic synthesis i will produce peptides containing unnatural amino acids loop and helix mimetics and also retroinverso analogues chitosancoated liposomal and silica nanoparticles will be used for targeted colon treatment as multifunctional systems nanocarriers protect the peptides chitosan enables mucoadhesive release and chitosan has also beneficial antiinflammatory woundhealing and antimicrobial effects on its own high regioselectivity and limited offtarget effects can be achieved by using gutstable peptides targeting local sites of inflammation compromised gut epithelium and biofilms since they are too large to cross the gut barrier orally administered peptide drugs targeting colonic tissues represent a highly innovative and safe route in treating gi disorders
stimulating performance of ecosystems in creative territories and regional actors

the spectra proposal embodies the collaborative vision of 8 partners including 3 associate partners representing 4 regional ecosystems an emerging innovator region in bulgaria northcentralbg moderate innovator region in ireland northern and western together with lead innovator regions in denmark hovedstaden and germany berlin spectra will put in place key ingredients required to equip the emerging innovator and moderate innovator regions with a more responsive resilient ecosystem capable of growing and developing coordinated responses to many challenges creative industries are facing to achieve the national and european goals this will be based on interaction with 2 successful initiatives media deals investment network and creative business network spectra will harness and multiply the power of individual ecosystem initiatives to enhance participation of financiersinvestors and women innovators resulting in enhanced more interconnected diverse genderresponsive competitive and sustainable ecosystems additionally spectra will include activities that will encourage development of joint strategies and amplify collaboration stakeholders will benefit extensively from the advanced business support models developed to fasttrack startups produce scaleups avail of best practice new systems structures and tools as well as datadriven carbonreducing challengebased innovation methods case studies role models crosssectoral and intraterritorial learning engaging over 1000 stakeholders over 30 workshops experimentschallenges huddles and roundtables supporting over 100 startups and smes and creating an excess of 300 new linkages spectra measures will be integrated within the context of policy economic societal framework and implemented on a transversal and transdisciplinary basis encouraging the maximum output in terms of potential for additional new linkages interconnections joint initiatives and replication
3dwheat a 3 dimensional functional genomics approach to identify hidden targets controlling heat stress and priming in wheat

in the global warming era heat stress is a major threat for both yield stability and yield increase plants have evolved a variety of sophisticated mechanisms to adapt to challenging environments epigenetic regulations allow them to dynamically reprogram their transcription machinery to adapt to an everchanging environment both histone marks and the 3d organization of the chromatin are instrumental for this coordinated regulation of gene expression according to environmental cues yet the overwhelming majority of available data on chromatin dynamics in response to stress has been obtained in arabidopsis and cannot be directly transferred to crops due to the expansion of ngs technologies we are currently facing a change of paradigm empowering the development of genomewide approaches on crops in this project we focus on wheat wheat is the 1st cereal worldwide for trade and the demand is expected to increase by 60 by 2050 my main objective is a thorough understanding of the priming for heat stress resistance in wheat to this end i propose to develop a new tridimensional d functional genomics approach integrating epigenomic 1d transcriptomic 2d and chromatin architecture 3d data to elucidate the molecular basis for priming in wheat moreover this project will go beyond addressing the challenge of deciphering epigenetic regulatory processes underlying priming it also includes the development of innovative tools for novel breeding strategies that will harness epigenetic variability in addition to genetic diversity we propose to generate a new generation of molecular markers that do not rely on dna sequence polymorphisms and that can be readily used in traditional breeding programs as such or as complementary tools for efficient qtl introgression such markers will be used to tag new traits to follow a new generation of alleles as well as to unveil new types of genetic diversity in existing collections of germplasms
rixisac reflective intelligent surfaceassisted intelligent and explainable integrated sensing and communication systems

sixth generation 6g communication networks are envisioned to deliver omnipresent network intelligence enabling a variety of applications such as vehicular networks smart health and smart farms these services require sensing information and then transmitting it to be processed or stored for future analysis to take actions that are related to the objects of the application and ultimately increase the quality of the provided service integrated sensing and communications isac aims to combine sensing and communication within networking systems thus enabling in practice the applications mentioned above isac systems face two main barriers i they are not supported by reconfigurable intelligent surfaces ris and ii are highly dynamic and complex this project is termed reflective intelligent surfaceassisted intelligent and explainable integrated sensing and communication systems rixisac rixisac will combine mathematical rigorousness and experimental evidence through the deployment of prototypes aiming at unlocking the potential of isac and bringing it one step closer to its practical realization in 6g networks within rixisac i will i explore risassisted isac systems by performing crosslayer optimization for a static and b dynamic scenarios and ii design realtime and explainable algorithms for risassisted isac
metalloenzymes and cells for green environmental alternatives

by far nature is the best chemist of all time according to nobel prize winner frances arnold mcgea will develop nature inspired strategies to help avert the pending climate catastrophe we will discover characterize engineer and exploit metalloenzymes as potent biocatalysts to efficiently perform chemically challenging reactions of high environmental impact specifically we will use metalloenzymes to tackle three burning issues that fall squarely in the remit of the eu green deal action plan co2 capture biohydrogen production and wastewater monitoring and remediation these challenges will be addressed using purified metalloenzymes incorporated into hybrid materials and live bacterial cells as selfregenerating catalytic metalloenzyme carriers implementation of these two strategies will proceed with research activities across the full pipeline of metalloenzyme development this will include i the assembly of the metallic cofactors as a prerequisite for establishing protocols for efficient metalloenzyme production ii rational redesign directed evolution and in silico strategies to develop enzyme variants that show improved catalytic activity and stability and iii the incorporation of the enzymes into matrices that allow for enzyme reusability stabilization or their selfassembly into multienzymatic nanostructures for substrate channeling the execution of this program relies on a strong interdisciplinary and intersectoral team the mcgea brings together 6 research groups from eu and 2 research groups from overseas all of them internationally recognized for their scientific excellence and 3 eu companies that will join forces to accelerate the transition to a climateneutral europe the consortium is designed to provide a diverse portfolio of skills through staff secondments to achieve integration from the stages of fundamental scientific discovery to the development of metalloenzymebased processes and prototype devices
reusable strategic space launcher technologies operations

salto will perform for the first time in europe fly recover refly cycles of a reusable rocket first stage demonstrator operating a largescale vehicle at low altitude consistent with future european strategic needs and embedding a set of critical technologies the project will significantly boost the strategic launchers roadmap enabling the vision of a future launch fleet improving by 50 space access costs and reducing environmental impacts salto will hence act as a stepping stone towards reusability of strategic launchers in europe which is one of the key leverages to reach such vision fully aligned with previous esafunded activities eg themis initial phase program salto focuses on technologies and building blocks maturation up to trl56 for the first stage of a strategic launcher subsystemsystem tests with two low altitude system tests hop test campaigns saltos methodology will combine robust system engineering with technology maturation activities and a stepped demonstration strategy to accelerate experimental learning through the implementation of the agile methodology the salto project will culminate in flight test campaigns to demonstrate and validate the technologies necessary for a reusable launch vehiclesalto will contribute to the cost reduction target for strategic launcher in europe by addressing 34 in cost of all technologies operations involved in a future european reusable rocket stage while europe is currently lagging behind other global players when it comes to reusable launchers salto will reinforce eus independent capacity to access space secure autonomy of supply for critical technologies and equipment and foster eus space sector competitivenessat the end of the project lessons will be drawn regarding the maturity of the different technological bricks trl and readiness for flight tests a roadmap to increase their maturity will be prepared in view of suborbital tests by 2025
sustainable rubber for the environment

current rubber sources are unsustainable existing rubber products are derived from natural rubber from the rubber tree the problem with the source of this rubber is deforestation of tropical rainforest and competition with food production rubber plantations are threatened by climate change and are vulnerable to disease and environmental hazards almost the entire global supply of natural rubber some 11 million tonnes in 2015 comes from southeast asia scientists at edinburghs botanic gardens estimated that more than 50 of plantations in the region might not be sustainable the second source of rubber is synthetic fossilfuel based rubber it is mixed with strong chemicals during production nordic biorubber facilitates the transition of fossilcentered industry of today to a sustainable bio economy allowing us to build a europe based supply chain decreasing dependencies on asia for the production of consumer goods which translates to a more robust economy
philosophy of cosmology matter and spacetime eradicated

our most basic fundamental assumptions are often the ones that get scrutinised the least this very much holds true for the primary ontological and conceptual distinction that underlies much of physics philosophy of physics and metaphysics the idea that all entities and structures in our universe are to be categorised and conceptualized as either space or in modern physics spacetime or matter never both never neither everything must be either the container or the contained although this strict conceptual dichotomy did make a lot of sense in the context of our pre20thcentury worldview the cosmomaster project contends that it is no longer tenable and even a hindrance to further progress more precisely each of the main ingredientsdark matter inflation dark energy black holes and general relativityof our highlysuccessful and wellestablished standard model of cosmology that was developed over the course of the 20th century puts pressure on the outdated newtonian idea that the spacetime and matter concepts can and should be strictly distinguished a systematic interdisciplinary analysis of the extent to which this dichotomy breaks down will have profound consequences for various debates in the philosophy of physics and metaphysics eg undermining the substantivalismrelationalism debate about the metaphysics of spacetime and providing novel opportunities to reassess and advance debates regarding conventionalism scientific realism and scientific guiding principles as well as for theory development and community interaction in cosmology and physics more broadly far from being an unwelcome babel a conceptual undoing giving up the spacetimematter distinction will provide guidance as to which traditional debates become moot and which novel avenues open up
autonomous scanning probe microscopy for life sciences and medicine powered by artificial intelligence

artificial intelligence is pushing forward the industrial revolution 40 which is transforming many areas of society including science and technology nanoscopy a recognized pillar of the research and manufacture of nanotechnologybased products is among the areas that more quickly is adopting artificial intelligence machine learning algorithms are being developed and integrated in microscopes for its autonomous operation and in software toolboxes for the automatic analysis of large volumes of microscopy data scanning probe microscopy is particularly active in this integration with a special focus in the life sciences and medical fields scanning probe microscopes powered by machine learning are expected to enable the autonomous and labelfree nanoscale structural and functional mechanical and electric imaging of living cells and functional biomolecules in their native conditions something never achieved in nanoscopic imaging the objective of the spm40 doctoral network is to train a new generation of researchers in the science and technology of autonomous scanning probe microscopes powered by artificial intelligence for applications in the life science and medical fields the researchers of the network will acquire a stateoftheart multidisciplinary scientific training in advanced scanning probe microscopy and machine learning and in their biological and medical applications in addition they will receive training on complementary and transferable skills to increase their employability perspectives and to qualify them to access to responsibility job positions in the private and public sectors the final aim is to promote the wide adoption of spm40 technologies in public and private research centers and in industrial and metrology institutions and to explore new horizons in the life sciences and medical sectors regarding labelfree nanoscopic cell imaging illness diagnosis or drug nanocarrier development consolidating europe as world leader
electrified liquidliquid interfaces supported in 3d printed platforms for rapid detection of benzodiazepine date rape drugs

the main objective of this work is to develop simple sensing solutions for benzodiazepines bdz date rape drugs detection the outcomes of this project are expected to be visible to citizens as the fully functional sensing solutions proposed innovation is a resultant of three main streams i 3d printing for the sensors development ii comprehensive electroanalysis of bdzs at the electrified liquidliquid interface elli and iii very meticulous electroanalytical screening focused on bdz and coexisting interfering species defined based on target real samples bdz are psychoactive species renowned for their ability to induce sedation aid sleep and are prescribed to treat a range of clinical conditions eg anxiety some bdzs and their structural analogues are classified as illicit drugs and are subjected to strict control the combination of bdz and alcohol was mostly related to drugfacilitated crimes such as sexual assaults due to related health and economic issues caused by bdzs it is necessary to strengthen their onthespot detection this project will develop elli based analytical tools to evade bdz related social crimes and health hazards 3d printing will be used to create sensing platforms that can be utilized on the spot further the solutions proposed in this proposal are expected to be fully applicable for the presumptive analysis of bdz drugs by nonexpects and possess commercial opportunities for widespread adoption the adviser and the researcher bring complimentary experience in the domains of elli and electrochemical sensors moreover the goal of this project is to enhance the innovative potential of researcher who wish to acquire new skills through advanced training mobility new environment and who is seeking to continue his career in research msca guidelines on supervision will be followed to foster soft and hard skills of researcher willing to contribute to solving the challenges defined by the msca green charter
transformational crossing system to prevent amputation and treat complex chronic total occlusions in critical limb ischemia

critical limb threatening ischemia clti is caused by chronic total occlusions ctos in the arteries of the lower extremities left untreated the complications of clti results in amputation of the affected limb the prognosis for those diagnosed with clti is comparative to an aggressive cancer at 1 year post diagnosis 25 of patients will die and 30 had an amputation 60 are dead by year 5cto is caused by the buildup and calcification of plaque inside the artery blocking the artery and hardens over time and prevents the passage of a guidewire or therapy device through the vessel versono has designed and developed a solution to allow an endovascular surgeon to confidently cross 90 of occlusions within 10 minsthis dedicated cto guidewire uses an acoustic wave ultrasound to penetrate through the calciumplaque and enable physicians to apply other treatments like stents balloons or atherectomy devices to unblock the cto and restore blood flow to the tissue downstream