Dragon09/odtu_chatbot huggingface dataset:
applying artificial intelligence to define clinical trajectories for personalized prediction and early detection of comorbidity and multimorbidity patterns

the aristoteles project aims to build a multinational harmonized data platform to develop and implement novel artificial intelligence ai approaches for management of complex diseases where progression and manifestations of comorbidities are via multiple interacting pathways we aim to apply our novel approach to a population of great need due to atrial fibrillation af but our outputs can be extended to other complex diseases with multimorbidity by integrating ais into clinical practice our platform will form a backbone for acceptable responsible and respectful uses of patientparticipant data to develop and validate novel trustworthy ai tools for more personalized risk assessment and management this represents a paradigm shift in af treatment moving from a focus on individual risk factors and selected outcomes eg stroke to a holistic approach underpinning timely diagnostic and therapeutic interventions to reduce disease progression disability hospitalizations and mortality as well as improve patient adherence to lifestyle modifications medications and other treatment regimensaristoteles will be delivered through 8 interlinking workpackages wps wp1 is study managementcoordination wp2 provides the ethicallegal requirements for the development of a trustworthy ai wp3 addresses stakeholder understanding of ai needs assessment and engagement in all the phases of the ai development in wp4 granular data on genotype and phenotype characteristics are harmonized from different datasets into a common platform in wp5 ai algorithmstools are developed and connected to an interactive output interface for patients and clinicians in wp6 we test the ai tool developed in wp5 in a clinical trial simulation in silico trial in wp7 a multicenter randomized trial runs across multiple countries including both primary care and secondary care wp7 and wp8 drive the clinical implementation and dissemination of results
heterogeneous singleatom catalysts for carbon dioxide reduction to chemicals

the increase in global energy consumption has been relentless as a consequence of population growth higher living standards and industrial expansion this has caused in turn acute problems with the release of vast amounts of carbon dioxide co2 into the environment which is linked to ocean acidification global warming and extreme weather conditions finding new routes to strategically capture mitigate and utilize co2 is thus a prioritythe catalytic conversion of co2 to chemicals is a promising pathway for transforming this waste into a precious platform molecule but the approach is still in its infancy the sacforco2 project will decisively contribute towards this effort by designing a novel class of singleatom catalysts sacs for a new purpose the conversion of co2 to make higher alcohols to this end sacforco2 will adopt an interdisciplinary approach which combines organoligandbased synthesis advanced characterization and a close synergy between experimental and theoretical research to gain a deep understanding of the nbased surface functionalization that guides single atom anchoring by integrating sacs into 3d printed membranes the project will also set up the technology for a costeffective conversion of co2 to chemicals this will provide fresh perspectives in catalyst design and build bridges between fundamental efforts on materials and device engineering achieving breakthrough performance under realistic conditionsfurthermore this action will establish an intraeuropean interdisciplinary network between emerging researchers in academia and industry at polimi italy and vito belgium and will allow an experienced researcher to consolidate a diverse set of scientific and soft skills gaining cuttingedge research competences new credentials in teaching and supervision and the possibility for collaborations with a broad eu network this will ultimately strengthen career prospects toward a scientific independence
advanced mapping risk assessment and naturebased depollution methods are combined to accelerate the recovery of contaminated soils and ensure that ecological restoration enters mainstream business

edaphos proposes a holistic and innovative land management approach to contribute to the mission a soil deal for eu and to its specific objective reduce soil pollution and enhance restoration edaphos will develop a framework for land rehabilitation and ecological restoration of contaminated areas featuring naturebased solutions nbs technologies to accelerate the recovery of contaminated lands to a healthy ecosystem status and making ecological restoration a mainstream business endeavor edaphos will improve the monitoring of contaminated soils and the understanding of precise pollution sources at selected eu regions by combining robust remote sensing tools and gisbased methods that will be applied at representative territorial lands sitespecific risk assessment methods and metrics based on the triad concept and considering the sources the pathways the exposure and effects of soil pollution will be developed and applied on 7 case studies edaphos will perform lab and field studies to validate the technological readiness and the costeffectiveness of nbs as effective remediation strategy for reducing soil contamination in urban periurban and rural settings and land uses edaphos will assess the environmental social and economic impacts of selected nbs sites and will develop the most suitable quantitative metrics and kpis that depict accurately and reliably their integrated socioenvironmental performance in both terms of economic benefit eg growth of ecosystem services value final phytoremediation compounds for further industrial valorization and cost prevention eg environmental footprint reduction potentials along with tailored ecological finance instruments for establishing a selfsustained and replicable eu nbs market with the aim of providing datadriven tools for forecasting analyzing and establishing quantitative relationship of multiscale processes artificial intelligence techniques will be implemented throughout the project
eupraxia preparatory phase project

eupraxia is a distributed compact and innovative accelerator facility based on plasma technology it has been selected for the 2021 update of the esfri roadmap in its first phase its consortium of 51 institutes and industry partners will construct an electronbeamdriven plasma accelerator in the metropolitan area of rome thus bringing innovation potential for spinoff companies stateofthe art scientific applications and a vibrant international user community to the middle of italy in its second phase eupraxia will build one laserdriven plasma accelerator at a site to be chosen between several options in europe eupraxia will serve users in ultrafast science eg on highresolution medical imaging deeply penetrating positron annihilation spectroscopy for materials and with europes most southern freeelectron laser fel it will offer fascinating capabilities for research on biomolecules viruses and microscopic processes eupraxia will thus be a transformative step in the development of ultracompact accelerators and applications the preparatory phase project eupraxiapp will prepare its full implementation
pen photoporation for the genetic engineering of therapeutic mesenchymal stromal cells and t cells

adoptive cell therapy has emerged as a promising strategy to treat cancer it relies on patientderived cells such as t cells and mesenchymal stromal cells mscs which are genetically engineered to become better equipped to fight cancer cells while ex vivo genetic modification of t cells and mscs has traditionally been performed with viral vectors they come with concerns about safety sustainable production and high development costs electroporation is a nonviral alternative transfection technology but can lead to significant gene expression changes phenotypic alterations and decreased therapeutic potency recently photoporation with electrospun photothermal nanofibers pen photoporation was demonstrated to provide a safer alternative with minimal impact on the cells functionality and phenotype the technology makes use of photothermal nanofibers which upon stimulation with laser light can transiently permeabilize cells to allow genemodifying effector molecules to enter the cells having been thoroughly demonstrated and validated in a research setting trl4 this project aims to bring the pen photoporation technology to tlr6 by developing hard and software for automated highthroughput transfections of t cells 1b cellsh and mscs 10m cellsh the technology will be extensively tested and validated in the cgmp compliant laboratories of the project partners for the genetic engineering of t cells and mscs at the same time steps will be taken to prepare for commercialization and market deployment by the end of the project a fully automated and validated highthroughput prototype system will be available for installation at centralized cell production facilities or ready for integration in pointofcare cell manufacturing equipment this project aligns with the micronanobio challenge as it combines nanotechnology with microfluidics to enhance genetically engineered cell therapy products
costeffective materials for sustainable electrolyzers

electrolysis technologies are pivotal in accelerating the transition from fossil fuels to renewable energy among them proton exchange membrane pem electrolyzers currently stand at an installed capacity of 092 gw and continue to grow in view of their desirable performance traits such as high operating currents and fast response however their reliance on perfluorinated materials such as polytrifluoroethenesulfonyl fluoride c2f4o2sn for core parts membrane and catalyst binder and critical raw materials iridium and platinum for catalysts raises environmental concerns due to the recycling challenges of forever chemicals the eu weighs a complete ban for forever chemicals such as perfluoroalkyl and polyfluoroalkyl substances pfas and cost the reliance on noble metal catalysts especially iridium does not contribute to high capital costs but poses scalability concerns due to the extremely limited availability of iridium overall these hinder the sustainability prospects of pem technologies at scale and their widespread commercialization these underscore the pressing need for innovative strategies to realize sustainable and efficient electrolyzersvital costeffective materials for sustainable electrolyzers addresses these challenges through the development of novel fluorinefree membranes integrated with costeffective noncritical raw materials vital aims to demonstrate electrolyzer systems for h2 generation which combine sustainable scalability and performance vital innovation relies on the development of fluorinefree membrane electrode assemblies implemented through a recyclable olefin polymer membrane paired with in situ grown catalysts free of platinum group metals pgms and designed to achieve competitive performance for h2 electrosynthesis this project addresses the need for scalable and sustainable electrolysis vital in the shift towards renewable energy sources and reducing fossil fuel dependency
antigender backlash democratic pushback

the goal of pushbacklash is twofold 1 firstly to systematically inquire into the presentday contestation of gender equality issues and policies at both elite and citizen levels approaching democracy from a global feminist perspective we employ a rigorous comparative multimethod design eg experiments surveys interviews participatory theatre our project enables a identifying antigender strategies as well as best practices in counteracting them across space and time and b assessing the effects of antigender discourses by focusing on parties social media and the public opinion secondly to 2 develop and test strategies that can effectively counteract antigender and antifeminist discursive strategies aiming at supporting the quality of democratic governance in more inclusive european societies we acknowledge intersections between gender and other social categories at all stages of the project composition of consortium and advisory board theory formulation empirical investigation and policy recommendations and thus engage with stakeholders to develop sustainable solutions we bring together gender activists eu experts and researchers from several fields of political science political theory public policy political parties public opinion political behavior anthropology communication and media philosophy sociology and social psychology pushbacklash is a transdisciplinary genderdiverse consortium aiming at equipping proequality actors with practical toolkits for responding to antigender equality and antifeminist discursive strategies and backlash tactics
akara violet robotic infection control system

akara is a spinout from one of europes leading robotics labs at trinity college dublin the founders collectively boast more than 40 years experience developing and deploying some of the most advanced robotic systems ever built to support frontline workers in the healthcare industry last year one solution was featured on the cover of time magazine a first for a european company akara offers violet an aipowered autonomous robot equipped with uv light a scientifically proven germkiller for disinfection of hospitals nursing homes and potentially endless other areas where harmful germs reside violet has been extensively tested in real clinical settings resulting in 3x more effective at killing germs 24x less time to disinfect rooms than the current approach violet is the only uv robot designed to be safe for use around people this overcomes fundamental limitations of stateoftheart disinfection technology which require rooms to be evacuated before and during use
distributed coordinated access point

in this project we aim to validate a lowcost cell free massive mimo solution for ultrareliable and lowlatency wireless communication based on wifi technology our solution called dcap or distributed coordinated access point is enabled by integrating distributed customized wifi 6 access points with the synchronous fronthaul technology developed in erc atto the following research innovations will be explored and demonstrated1 accurate time synchronization of the distributed aps with the bitinterleaved sigmadeltaoverfiber fronthaul network bisdof as developed in the erc advanced grant atto no695495 this novel fronthaul solution uses lowcost commercial optical transceiver modules connected with multimode optical fiber and is hence way more costeffective and flexible than coaxial cables a time synchronization accuracy below 10 ps is targeted2 lowlatency operation of distributed aps by exploiting the new ofdma orthogonal frequency division multiple access feature in the wifi 6 standard and extending it with beyond wifi 6 and wi fi 7 capabilities in ugentidlabs open fullstack openwifi prototyping platform with embedded wireless timesensitive networking tsn capabilities3 full compliance of the highly customized aps with wifi 6 commercialoftheshelf cots clients4 distributed beamforming by coherently combining resources units rus from multiple distributed aps thereby adding an extra degree of flexibility and scalability to the system as different rus subsets of ofdma subcarriers in the same channel can simultaneously serve different wifi clientsbesides the technical evaluation of the dcap proofofconcept the project will also explore potential valorization opportunities valorization will be facilitated by an already existing ip portfolio and an established industrial advisory committee
assessment of liquid source term for accidental post management phase

the socrates project addresses critical gaps in our understanding of the liquid source term during severe nuclear accidents and offers innovative solutions to mitigate and monitor the release of radionuclides into the environment the project contributes to the midtolongterm management of nuclear power plants after a severe accident by enhancing safety environmental protection safe waste management and public wellbeing the main contributions of the topical project are enhanced understanding of liquid source term new computer models for the liquid source term phenomena innovative absorbent materials to effectively trap key radionuclide species particularly cs and sr miniature size radiochemical laboratory for radionuclides education and training for nuclear safety recommendations for longterm operations waste management and severe accident management strategies the management of possible leakages of contaminated water which may happen more frequently due to aging of reactor components and joints will gain new remedies from socrates results to tackle and mitigate the contaminants inside the plant the projects research on the liquid source term directly impacts a majority of existing and new nuclear reactors encompassing diverse reactor designs and technologies recommendations based on socrates results will support nuclear community on international scale by giving guidelines how to manage liquid source term developed computer models for the analysis of liquid source term phenomena will benefit industry safety authorities and research community in the safety assessments of npps the models developed in socrates will be implemented in severe accident analysis codes such as ac2 and astec when the design of new sorbent materials for radionuclides will be performed with computer simulations it will enhance the digitalization of safety developments and enable considerations of multiple sorbent composition variations with low cost
atypical liquid crystal elastomers from materials innovation to scalable processing and transformative applications

alcemist challenges the conventional engineering mindset where passive static components beams wires joints are driven by active dynamic ones motors dampers sensors our innovative materials enable the combined functionality in a single component this bold ambition is feasible because our research will unlock the full potential of liquid crystal elastomers lces unique responsive materials that reversibly change shape colour adhesive or damping properties triggered by stimuli like heat light humidity or strain we propose a radically new sustainable materials platform based on polysaccharides functionalising precursors such that anyoneusing click chemistrycan make lces that are powerful yet biocompatible and biodegradable at one tenth of the cost of stateoftheart lces further using bondexchange chemistry alcemist lces will be reprocessable and reusable we also present a groundbreaking processing approach based on flow patterning to make largescale lces of complex shapes and actuation modes the synergy of three perfectly complementary and highly productive scientists each a recognised leader in their field enables this transformative approach to making atypical lcesas all our methods are ideal for industrial upscaling we will also demonstrate the yet untapped potential of lces when they are applied in atypical contexts totally different from the current mainstream academic focus these range from adhesives that can be reversibly debonded on demand or sunpowered adaptive building elements which save energy and improve indoor atmosphere to microhearts and peristaltic vasculature that can remove the growth limits of labgrown organs or smart threads that give doctors critical feedback on suture tension when conducting robotic surgery by overthrowing multiple conventions in the ways lces are synthesised studied and engineered alcemist will enable and stimulate new lines of research basic and applied across large communities
the milky way as key to understanding the inward transport of matter to the centre of galaxies

gas accreting onto supermassive black holes that sit at the centres of galaxies fuels the most powerful engines in the universe active galactic nuclei shaping the formation and evolution of their host galaxies yet we have a poor understanding of how the gas is transported from typical galactic radii rseveral kpc down to the area of influence of the black holes less than a few pc the centre of the milky way can be studied in much greater detail than any other galactic nucleus and is a rosetta stone to understand the physical processes that occur in all galaxies interstellar gas is transported from the galactic disc down to the central black hole sgra through a sequence of steps the galactic bar performs the first step by efficiently transporting gas from the disc r3kpc down to the ringlike accumulation of gas known as the central molecular zone cmz at r120pc in the last few years i have led major theoretical efforts to understand and quantify this first step however these efforts have also demonstrated that the bar is ineffective in driving the gas further inwards a longstanding question is how the gas continues from the cmz to sgra for the first time we have the possibility to answer this question thanks to new datasets and advances in numerical simulations i propose here an unprecedented effort to solve this important problem through a unified analysis of all the relevant physical processes based on novel data and methodologies i will combine recent and upcoming highresolution astrometric and spectroscopic data with advanced stellar dynamical models to constrain the gravitational potential in the galactic centre gc i will then use this potential to run cuttingedge numerical simulations to systematically quantify the contribution of all the mechanisms that can drive inward mass transport this will solve the problem of the inward mass transport in the gc and will give us fundamental insights that can be applied to all galaxies
mechanisms of memory formation in cortical networks during learning of goaldirected behaviors

a central hypothesis in neuroscience is that changes in connectivity patterns between neurons support learning and memory formation most methods for examining connectivity between individual neurons rely on ex vivo experiments eg in brain slices however in vivo measurements are required to study how neurons causally influence each others activity causal connectivity in the living brain and how these causal interactions change over time thus while brain networks are among the most studied biological networks the cellularlevel patterns and dynamics of causal connectivity in vivo remain unknown here i propose to study how causal connectivity between individual neurons and across entire brain areas changes over time during learning of memoryguided behaviors to this end we will use novel causal optical methods to longitudinally map causal connectivity and neural activity at cell resolution in vivo focusing on the motor cortex and related areas we will combine these methods with a novel goaldirected behavior in mice that does not require pretraining which will serve as a baseline to study learning mechanisms of more complex behaviors that rely on shortterm memory specifically we will map changes in causal connectivity during learning within the motor cortex aim 1 and across cortical areas aim 2 and relate it to the computational functions of the network we will also perturb neurons based on their connectivity and coding properties to identify changes in network mechanisms for shortterm memory and action selection at various learning stages aim 3 finally we will work towards identifying constraints on memory formation via optogenetic induction of artificial connectivity patterns taken together this research will enable for the first time to causally study dynamics in network interactions across time on different spatial scales and to test fundamental mechanisms of memory formation and representation in cortical networks