Dragon09/odtu_chatbot huggingface dataset:
reconnect science with the blue society

blueconnect gathers partners from 5 main coastal cities of the mediterranean part of croatia whose research is greatly characterized by natural biomedical environmental social and economic aspects of the sea mediterranean is severely affected by climate change and environmental degradation and at the same time dependant on marine resources and tourism and in need for enhancement of human relationships with the sea and science climate and environmental risks are recognized threats on eu level and globally and as such are addressed through several initiatives among which are green deal and sdgs the main objective of blueconnect is to reconnect science with society by bringing research and researchers closer to the public boosting public recognition of science and research education and building trust and understanding of science and its impact on the blue society in the region composed of 5 wps that reflect the overall objectives project will implement activities that promote research and science in an understandable and comprehensible way and encourage engagement of the general public and youth with science to jointly act on relevant problems facing the mediterranean awareness campaign will increase comprehension and understanding of science and attract youth and the general public to the main project events researchers at schools will implement interactive experiments and workshops to boost pupils curiosity and interest in research and science careers activities during the night will allow the public and youth to participate in experiments that will help them understand research and science to ensure the activities are achieving desired impact methodology and tools for evaluating the impact of project activities and the perception of the general public and youth will be developed and implemented successful implementation of the project will ultimately increase trust in research and science by the general public and youth in croatia
methyltransferase inhibitors for treatment of covid19

our ip secured drug dznep is effective in treating sarscov2 infections in preclinical disease models and uniquely suppresses virus growth triggers the innate immunity and facilitates tissue regeneration the ercpoc will enable the transition from preclinical to clinical research
anisotropic geometric variational problems existence regularity and uniqueness

the focus of this project is to advance the theory of anisotropic geometric variational problems a vast literature is devoted to the study of critical points of the area functional referred to as minimal surfaces however minimizing the surface area is often an idealization in physics in order to account for preferred inhomogeneous and directionally dependent configurations and to capture microstructures more general anisotropic energies are often utilized in several important models relevant examples include crystal structures capillarity problems gravitational fields and homogenization problems motivated by these applications anisotropic energies have attracted an increasing interest in the geometric analysis community moreover in differential geometry they lead to the study of finsler manifolds unlike the rich theory for the area functional very little is understood in the anisotropic setting as many of the essential techniques do not remain valid this project aims to develop the tools to prove existence regularity and uniqueness properties of the critical points of anisotropic functionals referred to as anisotropic minimal surfaces in order to show their existence in general riemannian manifolds it will be crucial to generalize the minmax theory this theory plays a crucial role in proving a number of conjectures in geometry and topology in order to determine the regularity of anisotropic minimal surfaces i will study the associated geometric nonlinear elliptic partial differential equations pdes finally in addition to the stationary configurations this research will shed light on geometric flows through the analysis of the related parabolic pdes the new methods developed in this project will provide new insights and results even for the isotropic theory in solving the size minimization problem in the vectorial allencahn approximation of the general codimension brakke flow and in the almgrenpitts minmax construction
in situ analysis of chaperone mediated protein folding and stability

molecular chaperones mediate protein folding and conformational maintenance failure of these fundamental cellular functions results in a breakdown of protein homeostasis proteostasis and facilitates the manifestation of diseases associated with protein aggregation much progress has been made in understanding the mechanisms of individual chaperone systems such as the hsp70s and the chaperonins based on analyses in vitro how these machineries function in the intact cell is not well understood however the goal of this proposal is to observe and characterize the dynamic action of the major chaperone systems and their interplay in intact cells in real timeusing live cell single molecule imaging combined with biochemical analyses proteomic profiling and genetic screening we will address the following questionsi how does the chaperone machinery assist protein chains during and after translation to achieve folding and assembly we will develop single particle tracking to monitor the chaperone engagement of nascent chains in situ in mammalian cellsii how is the conformational stability of chaperone clients assessed maintained and triaged in healthy cells and in cells burdened with pathological aggregates we will track the interactions of metastable proteins with chaperones and proteolytic machineryiii what is the efficiency of protein folding across the proteome under normal conditions and in chaperonedeficient cells pulse proteolysismass spectrometry will be developed to analyze the folding of nascent polypeptides and will be scaled to analyze the entire proteome of different cell types by depleting specific proteostasis components we will explore the capacity of the chaperone network for compensatory rewiring and identify vulnerable proteins with an obligate chaperone dependenceoverall this work will employ new technology to advance our understanding of the chaperone system in protein folding and proteome maintenance at the cellular level
the potential contribution of skeletal muscle to tdp43 associated als

amyotrophic lateral sclerosis als is a fatal neurodegenerative disorder characterized by motor neuron degeneration that leads to progressive muscle atrophy currently only a few fdaapproved drugs are available for als which merely extend patients life by a few months thus there is an urgent need for new and more effective diseasemodifying treatments although als is characterized by selective motor neuron degeneration extensive evidence indicates that other cell types contribute to both onset and progression of als an unresolved question in the als field is whether skeletal muscle fibers are merely bystanders or rather active contributors to motor neuron degeneration in als and if so through which biological pathways previous and ongoing work by the host laboratory has demonstrated the contribution of skeletal muscle in fusals 12 of als cases as tdp43 cytoplasmic inclusions are a universal feature in nearly all als patients assessing whether mutant tdp43 toxicity in muscle contributes to als may be relevant to the broad community of als patients i hypothesize that tdp43 toxicity in skeletal muscle contributes to motor neuron degeneration and alsrelated phenotypes through specific molecular programs i will use genetic and viral approaches to modulate mutant tdp43 levels specifically in skeletal muscle in a tdp43als mouse model and assess the effects on alsrelated phenotypes moreover i will use singlenucleus rna sequencing a cuttingedge technique that became recently available to determine for the first time the biological function of tdp43 in skeletal muscle in the context of als and to potentially identify novel therapeutic targets indeed if mutant tdp43 expression in skeletal muscle would influence the age of disease onset andor disease progression this would imply that therapeutic strategies for als should not only target motor neurons but also skeletal muscles potentially improving als treatment approaches
consolidating deep inclusive social innovation ecosystems

consolid8 is paving the way for the integration of social innovation actors in innovation networks in 15 european ecosystems using the quadruple helix collaboration from the challenges we identified in 5 pioneering ecosystems with different innovation performances strong innovator ireland moderate innovators italy greece slovenia emerging innovator romania we developed 5 capacity building programs that we will deliver to cater to the needs of 5 target groups from both the social innovation landscape and the classic innovation ecosystems we will harvest the lessons learned in delivering the different pioneering programs and we will exploit them in a followup european accelerator targeting additional 10 ecosystems which we will support through a validated methodology for accelerating ecosystems developed and implemented by deep ecosystems we will link the 5 pioneering programs showcase their results during a european social innovation festival in braov romania that will aim to interlink social innovation actors with innovation ecosystems we will ensure widespread visibility for this event at european level and we will launch an open call for the ecosystem builders to register for the accelerator for ecosystem builders the project proposes strong pathways towards achieving impact including activities aimed at developing 3 crowdfunding campaigns for social innovators 1 research on an alternative financing program for social innovation for local authorities or researching and testing and showcasing 12 social innovation models with potential of scaling up and replicability for the achievement of the projects results 8 partners across the quadruple helix are collaborating
nanoscale phovoltaics laboratory on a tip

next generation solar cells based on metal halide perovskite mhp materials promise cheaper and more energyefficient photovoltaic and optoelectronic devices compared to current siliconbased technologies to further advance mhp technology however will require fundamental understanding of processes leading to energy losses unstable operation conditions and premature aging the macroscopic properties of optoelectronic mhp devices are the result of the complicated interplay between structure and function thus the key to understanding mhp materials is to look at the many nano and microscale structures from subgranular twin domains over grain boundaries and interfaces to lateral variations in crystal orientations and facets the aim of this project is to reveal fundamental nanoscale processes and explore the connections to the macroscopic properties of mhp materials therefore we will develop nanoplot an innovative microscopy platform combining the lateral resolution of stateoftheart atomic force microscopy afm with the high temporal and spectral resolution of ultrafast optical spectroscopy nanoplot will not only allow spatially correlated mapping of eg the local electron dynamics or photoemission spectra together with the nanoscale surface photovoltage photocurrent or ion dynamics the most exciting possibilities will come from entirely new imaging methods based on combinations of the available scanning probe and optical methods using the 210 nm wide afm tip we will address and excite individual nanostructures enabling the characterization of optoelectronic properties at unprecedented spatial and temporal resolution the new experimental capabilities will enable addressing some key challenges of mhp research such as phase segregation and degradation effects interface heterogeneity and strain effects enabling a deeper understanding of loss mechanisms and intrinsic instabilities that will enable more efficient and stable mhp solar cells
atomiclayer additive manufacturing for solar cells

the alams project will provide the first application of atomiclayer additive manufacturing alam namely for the prototyping of solar cells in large arrays of microdevices the alam concept combines the principles of additive manufacturing 3d printing with the atomic resolution achieved by the thin coating technique atomic layer deposition ald in ald atomiclevel control is achieved by judiciously designing the surface reaction chemistry of molecular precursors at nearroom temperature for it to become selflimiting this renders experimental use of ald very robust to a wide range of parameter variations since the film growth occurs in a cyclic layerbylayer mode this advantage will be exploited towards 3d printing an area of application that ald has never been used for until we built the first alam prototype in november2019 this prototype centers around a printhead that delivers the ald precursors to the gas phase in the vicinity of the substrate surface with a microfluidic element delivering a lateral resolution on the order of micrometers the motion of the printhead with respect to the substrate allows the user to print lines and structures of arbitrarily chosen geometries whereby each pass over a given point of the substrate adds to it exactly the amount of material corresponding to one ald monolayer that is a thickness typically on the order of an atom or 01 nanometer depending on the exact ald reaction used after developing the ald chemistry needed for alam of the materials required to generate photovoltaic stacks the alams poc project will apply it to a case study namely the rapid prototyping of solar cell microdevices in large arrays the alam concept however is valid beyond the confines of photovoltaic research its commercial potential stems from its position at the convergence of two highly modern fastgrowing markets namely additive manufacturing 3d printing and microelectromechanical systems mems
insulation solution based on aerogels

the need for thermal insulation pertaining to space applications eg satellites and launch vehicles demands the requirement for the components of the satellite or launch vehicles to remain within the operating temperature range throughout the life of the satellite or the course of the journey the project isba proposes to develop a disruptive technology through seven different applications in the space sector based on aerogels or xerogels which will be used as a new thermal insulation solution in order to make it competitive clean compact easier to produce and assembly in the specific domain of space the impact of the project will enable an amplified profit at product level allowing to design new concepts way lighter by avoiding secondary structures for maintaining mli layout or rigid shield and cheaper than the reference solutions the technology thus assembled will guarantee a level of cleanliness compatible with the level of requirements of space applications which will be one of focal points of groundbreaking developments thus the overall objectives of the project can be summarized as follows i develop aerogelxerogelbased solutions for cryogenic moderate and high temperature space applications ii implement additive manufacturing technologies specifically for aerogels in space applications iii develop coatingtechnologies on aerogelsxerogels for operating in space environments iv improve cleanliness of aerogels by developing enveloping technologies tailored for aerogels v enhance industrial competitiveness of aerogelxerogel solutions in space and vi present euefficient alternatives to the current mli solutions thus reducing dependency on us technologies to achieve these objectives a consortium of three major enduser industry partners from eu five major research and development centers focusing on aerogels ceramics and coatings and one industry partner experienced in packaging technologies is established
end to end realtime interactive edge ai analytics platform for industry and automotive

we develop an endtoend edge ai platform targeting industry and automotive the platform enables data scientists engineers and domain experts with limited coding skills to interactively develop advanced realtime ai and analytics models for various edge devices and microcontrollersmcus our core technology and the platform we develop are based on extensive academic research performed by our cofounder professor emeritus tore risch and associates we enable large industrials to bring edge ai solutions to market faster more efficiently and with scale compared to other solutionsto date we have done ten pocs with industrials generating feedback for continued development of our platform we have significant work to do to develop the platform to a readiness level where we can accelerate our commercialization and bring in the next funding round to scale internationallywe are a team of 15 ppl experienced engineers and serial entrepreneurs with the ability to execute on our plans
food for the future environmental quantification and impact reduction

the foodture initiative aims at catalyzing a transformative shift towards sustainable and innovative practices within the european food sector through the development and validation of enhanced life cycle assessment lca methodologies and the promotion of stakeholder engagement foodture seeks to uncover effective strategies for sustainability and foster a resilient circular food value chain emphasizing transparency and open access the initiative performs ri on precision agriculture techniques and environmental stewardship practices to mitigate pollution and enhance holistic impact assessment foodture delivers 16 clusters of results including a wholevalue chain lcis of eu food systems b methodologies for improved life cycle impact assessment lcia c systemlevel impact quantifications including an analysis of tradeoffs and synergies between environmental social economic animal welfare and human health impacts d policy briefs open access free tools and capacity building sessions that stakeholders can use to integrate lcas in their daily operations all of this is performed with the continuous integration of all value chains actors in every step of the projects implementationthrough collaborative action and innovative solutions foodture prioritizes zero pollution and assessment of regionalized environmental impacts thus aspiring to set a new standard for holistic food system management driving meaningful progress towards a more sustainable and resilient future for european food systems
field sensors with exceptional energy resolution

fieldseer will develop magnetic sensors with combined spatial temporal and field resolution beyond what is possible with existing sensing approaches the energy resolution of a sensor describes this combined performance and determines a sensors ability to detect weak localized and transient signals in todays bestdeveloped sensors the energy resolution is known to be limited by a combination of intrinsic quantum noise and selfinteraction effects fieldseer will develop sensors that evade such limits and in doing so establish a new paradigm for extreme field sensing the immediate fruits of this new approach will be sensors for two exceptionally demanding contemporary applications first a spinor boseeinstein condensate comagnetometer will be developed to search for shortrange forces predicted by several models of physics beyond the standard model second opticallyaddressed nuclear spin ensembles will be developed as highdensity vaporphase magnetometers for nextgeneration magnetic brain imaging in both cases ordersofmagnitude improvement are predicted both for the energy resolution and for applicationspecific metrics fieldseer will also study how spin squeezing predicted to play an important role in these sensors due to their extraordinary coherence properties can be harnessed for optimal sensing in this new regime of exceptional energy resolution
revealing plasticity of developmental cell fate decisions by singlecell rna labelling

every time an egg is fertilised the cellular diversity of an animal must be rebuilt from scratch therefore a central question in developmental biology is how cells differentiate to acquire distinct fates a combination of genetics molecular biology and microscopy approaches has led to fundamental discoveries recently singlecell genomics has enabled the analysis of transcriptional differentiation trajectories at unprecedented scale and resolution however ordering single cells by transcriptome similarity only gives ensemble averages of differentiation trajectories and not the full spectrum of cell state transitions it then remains unclear whether cells can commit to their fate at different stages of development or change differentiation trajectories the sclab2fate project proposes to measure how singlecell transcriptomes change over time in living zebrafish embryos using a new rna labelling methodology this will reveal the full spectrum of differentiation trajectories during gastrulation allowing to see not only the major routes of differentiation but also rare alternative trajectories singlecell rna labelling biochemical nucleoside conversion and sequencing will be used to measure mrna kinetics and transcriptome dynamics of zebrafish embryos at singlecell resolution spontaneous cell fate changes during normal development will be contrasted with induced cell fate changes upon cell transplantation from different cell types to decipher signalling interactions this project will leverage singlecell genomics and traditional approaches in developmental biology to build a conceptual framework for analysing embryonic development as both a genetically programmed and a selforganised phenomenon and to provide a general blueprint of how one can study perturbation response using metabolic labelling in living systems
quantum simulation with longrangeinteracting dysprosium and erbium from microscopy to rydberg tweezers

dymeter aims at creating novel quantum platforms of enhanced capability by using ultracold erbium and dysprosium atoms as buildingblock to unprecedentedly access manybody phases of dipolar mixtures dipolargas microscopy and multivalenceelectron rydberg quantum simulators by pushing the limits of interaction control using tailored optical potentials and rydberg excitations as well as state readout through the application of quantumgasmicroscopy techniques we will harness the multivalanceelectron nature of magnetic lanthanides to deepen our understanding of unconventional phases and phenomena of quantum matter in particular those arising from the combined effects of short and longrange interactionsthe main project objectives arethe bulk phases of matter in dipolar quantum mixtures accessing the unexplored miscibilityimmiscibility phase diagram of dipolar quantum mixtures in the droplet and supersolid regimemicroscopy and lattice physics with quantum dipoles developing quantumgas microscopy for magnetic atoms to access quantum simulation with longrangeinteracting atomic systemstweezer arrays with multivalenceelectron rydberg atoms realizing novel rydberg quantum simulators exploiting the multielectron nature of magnetic lanthanide atomsour project is very ambitious but if successful has clearly the potential to break new ground in dipolar quantum physics with ultracold atoms