Dragon09/odtu_chatbot huggingface dataset:
mitigating stellar magnetic activity contamination in transmission spectroscopy

transmission spectroscopy ts is a technique which measures the wavelengthdependent radius of a planet as it transits its star from this information about the chemical composition of a planets atmosphere can be obtained the observed transmission spectrum is a combination of the planet and its host star inhomogeneities caused by spots and faculae present on stellar surfaces cause temporal changes in the observed transmission spectrum mimicking a planets signal it is crucial to understand the imprints of faculae and spots on ts to mitigate their signals modelling of stellar activity is challenging and interpreting the stellar signal is full of degeneracies the community is eager to overcome the stellar contamination conundrum for which incite will propose solutions incites objective is to build a methodology for stellar activity mitigation by physically modelling stellar activity in contemporaneous multipletechnique observations as stellar activity models rely on the knowledge of the surface distribution of magnetic features and their respective brightness spectra incite will combine recent efforts in these areas the only star for which simultaneous observations of both the distribution of spots and faculae as well as multitechnique observations are available is the sun therefore the first step within incite is to accurately model sunasstar observables another star presents itself as in ideal testbed gj 1214 is a cool small star for which observations in multitechniques together with observations in ts by nasas jwst are available based on those two stars stellar activity indicators that will allow for the most accurate mitigation of stellar activity in ts will be identified additionally extensive studies will be conducted on how different configurations of magnetic fields will affect those activity indices and the mitigation in ts this makes incite a proofof concept study highly anticipated by the community
computeraided effective fracture risk stratification of patients with vertebral metastases for personalised treatment through robust computational models validated in clinical settings

cancer patients 27m in europe with a positive prognosis are exposed to a high incidence of secondary tumours 1m bone metastases spread to the spine in 3070 cases reducing the load bearing capacity of the vertebrae and triggering fracture in 30 cases clinicians have only two options either operate to stabilise the spine or leave the patient exposed to a high fracture risk the decision is highly subjective and can either lead to unnecessary surgery or a fracture significantly affecting the quality of life and cancer treatmentthe standardofcare to classify patients with vertebral metastasis are scoring systems based on radiographic images with little consideration of the local biomechanics current scoring systems are unable to establish an indication for surgery in around 60 of cases thus there is an unmet need to accurately and timely quantify the risk of fracture to improve patient stratification and identify the best personalised treatmentthis interdisciplinary project will develop artificial intelligence ai and physiologybased vph biomechanical computational models to stratify patients with spine metastasis who are at high risk of fracture and to identify the best personalised surgical treatment after rigorous model training with clinical 2000 retrospective cases and biomechanical 120 ex vivo specimens data the new approach will be tested in a multicentric prospective observational study 200 patients the models will be combined in a decision support system dss enabling clinicians to successfully stratify metastatic patients the models and the dss will be designed so as to be suitable for regulatory requirements and future exploitationmetastra will propose new guidelines for the stratification and management of metastatic patients metastra approach is expected to cut the uncertain diagnoses from the current 60 down to 20 of cases this will reduce patient suffering and allow cutting expenditure by 24byear
accelerating the deployment of offshore wind using dc technology

renewable power is one of the main drives to achieve carbon reduction and netzero and to meet the ambitious climate goals in particular offshore wind power in europe has been developing at a rapid pace in recent years multigiga watts offshore wind farms with larger wind turbine power ratings floating wind turbines installed in deeper water areas and higher ratio of renewables integrated to existing power grids are fundamentally changing power system operations and bringing new challenges and technical demandsthis industrydoctorate consortium adored will recruit and train 15 researchers by collaborating with 19 academic and industrial organisations it aims to tackle the academic and technical challenges in the areas of transmission of offshore wind power to the ac grid by using power electronicsbased acdc technologies in doing so it will equip the researchers through their phd studies with essential knowledge and skills to face fast energy transition in their future careersthe project covers 3 key research aspects offshore wind including wind turbines wind power collection and wind farm design and control dc technologies including acdc converters hvdc control and dc network operation and protection and ac grid including stability and control of ac grids dominated with converters under various control modes the adored consortium has excellent coverage of academic universities and industry organisations including manufacturers energy utilities system operators consultancy and technology innovation centres all the research questions in the project reflect industry needs academic novelty and innovation will be reflected in the methodologies and solutions and the research results will be disseminated directly to the industry partners products grid operation and services the outcomes of the project are both technologies and a talent pool to accelerate the deployment and grid integration of largescale offshore wind power
advanced multiscale biological imaging using european infrastructures

the amber consortium has been assembled for the exploitation and development of largescale european infrastructures to address key needs for biological imaging this covers length scales from molecular through cellular to tissue organ and organism levels of organisation amber brings together four research centres and three large scale research infrastructures with a wide range of competence including clinical practitioners biological and biomedical scientists physical scientists and facilityinfrastructure experts we exploit an ongoing convergence in the scientific landscape in terms of european central facility development data management and data analysis and interpretation coupled with the explosive growth in the application of artificial intelligence and machine learning approaches it is hard to imagine a time for which there has been a bigger need to bring together communities from different fields in an adaptive and progressive way in addition to the gaps of knowledge that exist between different levels of organisation eg between molecular and cellular levels there are also major gaps in scientific culture for example between clinical and fundamental science amber will create fellows with unprecedented medical biological and methodological capabilities with a profound potential impact for europes next generation of research and researchers this 5year programme will recruit 42 postdoctoral research fellows in three calls of 14 fellows each with each fellowship of 36month duration work will include technique development particularly in terms of combining imaging techniques and data to provide a more integrated picture of life processes in the context of health disease fellows that have completed this programme will be extraordinarily well equipped to further their career in academia at infrastructures in the health and medtech sectors and beyond
machine learning for sciences and humanities

smash is a brandnew training and research programme to be cofunded by the slovenian ministry of science education sport the beneficiary the university of nova gorica is a researchfocused university situated at the italian border that boasts a 5149 femalemale ratio among its 200 staff the programme is designed to enhance the career prospects of outstanding postdocs from around the world while strengthening europes human capital in ri fifty talented individuals will be hired by five of slovenias leading institutions allowing them to expand their own research ideas based on access to the datascience potential of the vega hpc supercomputer the first such facility of the eus multibillion hpc initiative with a diverse group of associated partners including top smes from slovenia and the eu as well as worldleading institutions like uc berkeley smash will form a closeknit community with a single unifying concept the use of cuttingedge data science to answer some of the worlds most challenging questions these include predictions related to the impacts of climate change the development of personalised medicine finding answers to fundamental questions about our universe and digging deep into the fundamentals of language and how we communicate smash will guarantee a recruitment process based on openness transparency impartiality and equality and will ensure neutrality by giving all selection power to external experts setting an example for the region toplevel training in applications of machine learning that is one of todays most transferable skills will be complemented by rich softskill training opportunities developed in collaboration with some of the worlds best experts including cerns learning hub the impact of the programme will be felt for decades both in the local research landscape and across europe as the researchers take their skills to pursue their careers on the strength of their successes in smash
from stick to screen digital editions of runic inscriptions as research tools

the project from stick to screen digital editions of runic inscriptions as research tools will create a borndigital interactive and openaccess critical corpus edition of the runic inscriptions from the four medieval norwegian trading towns bergen trondheim oslo and tnsberg it will address the challenges of proper digital representation of runes from a multidisciplinary perspective aiming to present a solution to existing challengesthe main objective of the project is to examine new ways of digitally editing and analysing runic inscriptions with a view to how digital museumseditions can be actively used to conduct research two case studies will be undertaken to show how the new digital edition of the runic inscriptions from bergen trondheim oslo and tnsberg can immediately be used as a tool for research the case studies represent two further research objectives of the project the first case study focuses on the diachronic and geographical spread of runes and variations of runes within these four towns and will try to identify regional differences in the use of certain runic characters in the material the second case study will analyse the diachronic and geographical spread of the names appearing in the runic inscriptions from these four towns with a view to the identity geographic mobility and gender distribution of the runecarversthe project will rely on the infrastructure at the museum of cultural history university of oslo to publish and link highquality photographic documentation of the runic inscriptions to data collected about these inscriptions photographs and research data combined will form the new digital edition this in turn will be made accessible to all interested audiences at the end of the project as an interactive tool the results of the two case studies will be directly accessible when using the digital edition furthering understanding and knowledge about medieval runic inscriptions from trading towns
silk fibroin tissue grafting for peripheral nerve repair

peripheral nerve injury is a major source of disability impairing muscle movement or normal sensations 4mn people annually experience traumatic nerve damage current solutions do not always achieve full motor and sensory recovery leading to loss of sensationfunction and pain with a significant impact to patients lives with 50 unsuccessful nerve repair procedures patients require prolonged rehabilitation and 30 of them experience permanent disability producing a high socioeconomic burden klisbio has developed silkbridge a novel costeffective nerve guide made of silk fibroin for safe and efficient peripheral nerve repair klisbios solution clinically tested with a first in human fih study supports and protects the regenerating nerve from compressive forces restoring its function and reducing pain without patient discomfort silkbridge enhances nerve healing without immune rejection nor fibrosis reducing the costs of rehabilitation and prolonged surgeries
darwinian chemistry doctoral network

darwinian evolution is unrivalled in its ability to invent which humankind has already exploited for various purposes such as plant and animal breeding and directed evolution of proteins in these examples evolution acts on living species or material derived from them but so far it has not been possible to apply darwinian evolution outside the realm of biological and some computational systems the aim of the darchemdn research programme is to develop darwinian chemistry by creating for the first time synthetic chemical systems that can reproduce and undergo openended darwinian evolutionour pioneering concept will be implemented in a joint effort by 10 doctoral candidates dcs working on 1 the identification and development of viable autocatalytic systems 2 incorporating these systems into compartments emulsions and coacervates to couple autocatalysis to compartment growth and division and 3 integrating metabolism in the new systems to 4 enhance evolvability and achieve darwinian evolutionwe have assembled a consortium of scientific excellence that brings together multiple erc grant holders supervisors of several previous mscaitns and highly innovative companies with complementary expertise to deliver this unique research and training programme exploiting the full potential of the envisioned scientific breakthroughs requires a structured training programme to equip the first generation of darwinian chemists with advanced scientific business and transferable skills in the longterm we envision that the darchemdn dcs will unleash the power of darwinian evolution to have a profound impact on applied chemistry and materials science in areas ranging from catalysis to sensing and signalling by allowing optimisation of functions through evolution
the celestial road to a holographic description of black holes

black holes are at the root of the most striking puzzles that arise when attempting to combine quantum mechanics and general relativity they are therefore thought to be key to a formulation of a theory of quantum gravity in recent years progress in our understanding of the elusive quantum nature of black holes has been made thanks to the socalled holographic correspondence which has provided theoretical physicists with a powerful tool to study quantum gravity however these methods are so far only fully developed for antide sitter spacetimes whereas understanding realistic black holes would require to develop a holographic correspondence for asymptotically flat spacetimesthe aim of this project is to make major steps towards a holographic description of quantum gravity in asymptotically flat spacetimes and to address some of the unresolved key issues in black hole physics especially in understanding the mysterious origin of their vast entropy to do so i propose to combine two novel emergent ideas the first is a new approach to holography in flat spacetimes called celestial holography which proposes that quantum gravity in flat space can be described by a celestial conformal field theory living on the sphere at infinity the second is based on the recent discovery in my previous works of the existence of intriguing infinitedimensional symmetries that appear close to black holes event horizon the infinite set of asymptotic conservation laws in the presence of horizons is awaiting to be unraveled as it will reveal unexplored constraints on information flow for black holes in flat spacetimesthanks to this unique combination of powerful approaches based on symmetry principles my research project aims at addressing the challenge of a holographic formulation of spacetimes that include realistic black holes such as the ones we observe in the sky
piloting innovative insurance solutions for adaptation

the eu member states should step up their climate change adaptation efforts alongside their intensifying mitigation efforts next to and in conjunction with physical and organizational measures that directly reduce climate change risks insurance and related risk sharing solutions have an important role to play innovative insurance solutions and risk sharing are crucially needed to incentivize adaptation efforts in terms of both volume and effectiveness while also directly contributing to building more resilient societies the piisa project aims to develop and deploy a range of insurance innovations that incite households and firms to adapt proactively and sufficiently for their own sake and their neighborhoods sake piisa also incites public authorities to set up adaptation and create adaptation promoting conditions piisa codevelops climate resilient insurance portfolios and develops solutions for sharing losses and climate risk data the piisa project matches scientifically underpinned new insurance concepts with handson demonstration of their operability effectiveness and acceptability extensive user involvement contextual sensitization affordability and viability are key features of the new products the choice of new product developments and sectoral applications will be based on a careful analysis of the adaptation and insurances gaps and their interactions as well as on deepening productmarket feasibility analyses piisa focal sectors are agriculture forest sector and cities and citizens wellbeing involving a host of climate enhanced hazards such as floods droughts forest fires biotic risks and various types of storms the consortium counts 12 partners from 5 countries piisa involves 3 insurance companies who will actively participate in the insurance pilots conducted in 8 countries also using their vast multimillion customer base
modular pulsed propulsion system

mp2s is an innovative project aiming at filling the gap on the 200w class propulsion modules this power segment being largely popularized by the new space market actors the main goal of the project is to mature and develop up to trl5 a pulsed mpd arc discharge chamber as a building block for an electrical pulse propulsion modular concept the consortium is composed of high level specialists representing industry comat endurosat and plasma solve and research and technology organizations cnrs two laboratories icare and laplace university of stuttgart they have a broad experience and knowhow in the area of electric propulsion plasma physics simulation tests mass manufacturing and business model for space cnrs and university of stuttgart will perform experiments and modelisation for a better understanding of physical phenomena of pulsed propulsion that will allow to characterize different propellant choices current discharge wave form and magnetic topology the consortium will also perform studies to optimize the cathode erosion in pulsed mode allowing to design new electrodes for a significantly increased thruster total impulsion then plasmasolve will customize a software able to simulate different configuration of the pmpd thruster design iterations will be performed to reach the required level of performance based on those results the integrated pulse mpd building block with integrated fluid management system will be developed and validated with outstanding performances the modularity and versatility of the propulsion module will bring value to the satellite and enable new inorbit mission design by endurosatie docking the industrial strategy will ensure competitive cost mass production capacity and easy assembly thanks to additive manufacturing technology and plug and thrust concept the mp2s partners will disseminate this disruptive and modular solution within the new space market while supporting the european space strategy
neuronal networks dynamics underlying spike timing precision during brain developmental plasticity and alzheimers disease progression

brain plasticity and neuronal network oscillations are crucial brain processes that depend on the timing precision of neuronal activity these processes change during healthy brain development and are disrupted early on alzheimers disease ad with controversies on the onset of their impairment thus comprehensive studies of plasticity considering the state of the neuronal network during development and ad progression are missing here we will address the mechanisms underlying timingdependent plasticity by the convergent study of spike timingdependent plasticity and neuronal networks rhythms in mice hippocampal slices the work plan includes logical sequential sets of experiments involving exvivo electrophysiology combined with multiphoton imaging optogenetic calcium dynamics molecular biology and immunohistochemistry during healthy development in wildtype mice and the progressive impairment of neuronal circuits dynamic in an ad mice model the action will be implemented during 2 years in the laboratory of cellular neuroscience and plasticity lcnp lead by professor antonio rodrguez moreno supervisor and hosted by university pablo de olavide upo in seville spain all the premises and infrastructures owned by upo are at full disposal for both the candidate and the supervisor manager of the infrastructure of multiphoton unit during the action the researcher will acquire intellectual skills and learn sophisticated and cuttingedge approaches to assess synaptic plasticity supported by his previous skills and the strong supervisors background the expected outcomes from the insertion in a suitable scientific and academic environment at lcnp and upo will lead the candidate to establish as a young pi within the spanish science system lcnp and upo will establish the study of neuronal dynamics in a highly convergent way and nurture from the candidates expertise acquired in both the ki and during the fellowship