Dragon09/odtu_chatbot huggingface dataset:
training alone to play together app

making music together requires not only individual skills and musical expertise but the ability to coordinate ones actions with others typically musicians try to improve their joint performances by practicing together however musicians encounter two kinds of obstacles when trying to improve their joint music making skills one obstacle is the lack of sufficient opportunities for joint rehearsal the other obstacle is the lack of researchguided exercises that would allow for learning transfer across pieces partners and different coordination problems based on the results of an erc consolidator project investigating the behavioral cognitive and neural mechanisms involved in joint action learning we propose to develop an app that allows musicians at any level of expertise to improve their joint playing skills two aspects of the app make it possible to overcome the typical limitations of joint practice first with the knowledge gathered during the erc consolidator project we will be able to program virtual partners with whom musicians can train their ensemble skills individually outside of resource intensive joint rehearsals second the app will focus on training the ability to flexibly shift between selfother integration and selfother segregation which is a highlevel skill with a large potential to generalize to a wide range of pieces and playing styles the app will be webbased and freely accessible to a large pool of users its effectiveness will be thoroughly tested in the lab and in the field to assess its value for musicians playing in smaller and larger ensembles as the first app directly training joint music making taptapp will provide new opportunities for musicians and has the potential to transform music education
circuit mechanisms of cortical predictive learning

to perform sensory guided behaviors animals need to distinguish selfgenerated and externally generated sensory inputs predictive processing theories propose that the brain does this by learning to predict sensations caused by selfmotion the key signals thought to drive this learning are prediction errors differences between predicted and actual sensory input my previous work shows that neurons in the primary visual cortex v1 compute visuomotor prediction errors and that prediction errors activate the locus coeruleus a brainwide neuromodulatory system we will now investigate the circuit and neuromodulatory mechanisms underlying the learning of sensory predictions using v1 as a model i hypothesize that input to v1 from higher order cortical areas undergoes plasticity during selfgenerated sensory feedback this plasticity should be driven by prediction errors in v1 activity modulated by locus coeruleus output and improve detection of externally generated visual flow during selfmotion we will test this hypothesis using innovative methods including a multimodal virtual reality system and a novel object detection task combined with in vivo whole cell recordings twophoton imaging and optogenetics the specific aims are to 1 investigate how prediction errors are communicated between the locus coeruleus and the cortex 2 decipher the mechanisms of predictive plasticity within the v1 circuit and 3 assess the behavioral relevance of this plasticity the knowledge gained will have a fundamental impact on our mechanistic understanding of predictive learning in the cortex and the role of neuromodulation in this process which will have significance for 1 understanding conditions in which the processing of selfgenerated sensory feedback is thought to be disrupted eg neurodevelopmental conditions and psychosis and 2 development of ai and brainmachine interfaces that deal with selfgenerated sensor feedback eg prostheses
a digital edition of greek and roman sculptors signatures 323 bce138 ce

sculpsi aims at reconstructing the lives and the works of greek and roman sculptors between the hellenistic period and the reign of hadrian 323 bce138 ce in the areas corresponding to roman italy and the provinces of achaia and asia sculpsi focusses on sculptors signatures taking them as a source of information and a starting point for reconstructing their professional careers signatures open up many research paths that have yet remained unexploited their wording their position on statues or bases palaeographic dating language and dialect etc they can also help us to reconstruct the work of individual sculptors attribute them specific artworks and track their mobilities in the mediterranean sculpsi will be the first systematic study on sculptors signatures between 323 ce and 138 ce the analysis will be carried out on a corpus of ca 550 signatures and will be based on bibliographic data and whenever relevant autoptic study such data will be used to feed polycles a prosopographic database already created by the limc team at my host institution but still awaiting launching the project breaks down disciplinary barriers by combining art history epigraphy archaeology and digital humanities and posing theoretical questions eg role of the artist within society the idea of authorship which go well beyond classical studies the database only one of the research products of sculpsi will constitute a perennial gate for scholars and students of several disciplines giving access to data scattered in different parts of europe and beyond and to the first english and french translations of many inscriptions besides being trained in digital humanities the researcher will develop a unique expertise in epigraphy and ancient art history filling a gap between disciplines which rarely communicate collaborations with international museums and academic institutions will open up several opportunities for the researcher both in france and abroad
complete characterization of photochemical reactions by time and energyresolved electron scattering

many processes in nature and industry are intricately linked to the structurefunction relationship of molecules which optical stimuli can profoundly alter chemists and physicists have long sought to unravel the ultrafast structural changes of photochemical reactions using two short pulses with precisely synchronized time delays a series of snapshots of the evolving electronic and molecular structures at various reaction times can be collected analogous to assembling frames in a video measuring coupled electronicnuclear dynamics remains a formidable challenge due to the small time energy and spatial scales involved stateoftheart ultrafast electron diffraction ued techniques excel in molecular structure retrieval but the critical signatures stemming from simultaneous transformations in electronic structure remain elusive as several molecular reaction channels overlap and cannot be separated with current imaging technologiesmy goal is to pioneer a novel time and energyresolved electron scattering teres method for realtime monitoring of coupled electronicnuclear dynamics in photochemical reactions by energyresolving ued teres will experimentally separate and identify electron scattering signals arising from different electronic structures of excited molecules eg in different excited states while preserving molecular structure information comprehensively mapping the potential energy surfaces involved at different reaction times capabilities significantly exceeding current ued technology successful realization of teres promises to usher in a new era in photochemistry unveiling hidden aspects of chemical reactivity
musculoskeletal expansion

people that suffer from severe muscle weakness of the upper limb following neurological disorders still struggle to find assistive technologies able to help them in their daily life the most advanced technologies consist of wearable exoskeletons either rigid or soft that promise to support the wearer during daily living despite their great potential the widespread adoption of exoskeletons where they are most needed ie for continuous daily home assistance is prevented by several flaws limited efficiency controllability and lack of reliable ways to connect them to the user muse musculoskeletal expansion abandons the paradigm of wearing an exoskeleton to develop and clinically assess soft external muscles exomuscles intimately connected and naturally controlled by the user the core objective is to develop innovative efficient exomuscles to support people with severe muscle weakness with my solid experience in soft robotics and innovative materials i will develop them by combining the extreme portability of pneumatic actuators made of textiles with the energy efficiency and promptness of nonlinear elastic structures they will be reliably connected to the user through fixtures implanted on the bones which will grant the excellent mechanical stability of osseointegration widely adopted in dental prosthetics and increasingly explored in limb prosthetics but still unexplored in exoskeletons this approach will unlock the potential of eliciting osseoperception ie sensory feedback necessary to control motion through bone conduction if successful muse will benefit all those in need of sensorimotor augmentation as it can be extended to all kinds of exoskeletons from upper to lower limbs from assistive to augmenting devices moreover since muse connects the inner body to the external world it may be the cornerstone to build a bidirectional gateway between them bridging the human and the machine to a more and more intimate level
shifting perspectives visibility and voice of women in worker cooperatives

the wecoop project shifts our traditional androcentric perspective on workplace democracy by investigating the labour experiences of women in worker cooperatives studied for their high potential in the democratization of labour relations worker cooperatives have been systematically considered as a site for class struggle only wecoop excavates how and why worker cooperatives are also a locus where yet unexplored sets of representations practices and justifications pertaining to womens emancipation and gender equality at work are producedopening a whole new field of enquiry crisscrossing the topics of gender labour and democracy the project addresses two series of questions that cover respectively womens visibility and voice first to what extent and how does the democratic apparatus of worker cooperatives allow women to reconfigure labour according to their needs and problems to reevaluate the traditional separation between the public and private sphere and to redefine political imaginaries pertaining to their emancipation at work second are there genderdifferentiated scripts of cooperative labour and if so how can they expand our understanding of workplace democracy towards more inclusive analytical frameworksfocusing on the casestudy of france the project is based on a multilayered survey of worker cooperatives as well as rare forms of allwomen cooperative experiments it combines quantitative and qualitative methods with an innovative participatory research in four incremental steps allowing for the appropriation by women workers of their narratives and strugglesby unfolding the visibility and voice of women workers wecoop will contribute to the ongoing research on participatory methodologies produce an unprecedented digital narrative archive on cooperative labour fuelling further research expand our knowledge on genderdifferentiated scripts of workplace democracy while opening a new field of inquiry on feminist utopias at work
ecm and tfeb interplay from building multidisciplinary devices to unravelling the missing link in cancer

over the last 30 years researchers have shown that tumor cells not only need to accumulate oncogenic genetic alterations but also rely on permissive cues from a surrounding extracellular matrix ecm for malignant progression however reconstructing the tumor niche in vitro has not been easy due to the complexity of its intertwined physico biochemical properties and the limitation of the available biomimetic scaffolds furthermore preclinical studies have mainly focused on druggable targets at the intracellular signaling level and overlooked the implication of the ecm to overcome these hurdles we will unravel the ecm mechanochemical contribution in tumorigenesis and its continuum interaction with tumor cells in 3 steps first we will deconstruct bladder cancer ecm through indepth analysis of its physical and biochemical features this will provide us a blueprint to follow in order to build a tailored microenvironment for bladder tumoroids then we will reassemble ecm properties in a new generation of tunable materials functionalized with ecm proteins secreted by bladder cancer cells in vitro using our developed tumoroid model we will finally chart the reciprocal crosstalk between extracellular cues and transcription factor eb tfeb an emerging oncogene and regulator of tumor microenvironment by bridging the gap between ecm and tfeb regulation we anticipate to catalyse the success of cancer prevention and therapy leveraging new druggable targets at the level of the reciprocal feedback between the evolving ecm and tumor cells
getting to grips with aaa atpases encoded by positivestrand rna viruses

noroviruses novs and enteroviruses evs cause numerous gastrointestinal and respiratory infections their contagious nature and high mutation rates can lead to the emergence of new pathogenic strains understanding these viruses is crucial for controlling outbreaks and to maintain global health both novs and evs are members of the order picornavirales and share commonalities in their replication strategies their positivestrand rna genomes encode nonstructural proteins nsps that exploit host cells to create membranous replication organelles for genome replication and virion formation the most enigmatic nsp encoded by these viruses is a aaa atpase nov ns3 and ev 2c these enzymes have many proposed roles in the virus lifecycle such as rna helicasechaperone activity membrane rearrangement and genome encapsidation however their structure and the molecular basis for their diverse activities are poorly understood due to challenges in producing stable and soluble complexes for structural analysis and the lack of tools to accurately visualize nsps in a cellular context drawing from my decadelong experience in structural virology and recent success in engineering soluble aaa atpases i aim to unravel the multiple functions of nov ns3 and ev 2c specifically i will 1 decipher the structurefunction relationship of these enzymes through singleparticle cryoelectron microscopy analysis of the nucleotide and rnabound complexes 2 create a toolkit of small molecules and nanobodies to investigate the functional sites in ns3 3 utilize cryoelectron tomography to visualise ns3 and 2c in infected cells guided by genetically encoded tags developed in this project collectively the results of this project will provide new mechanistic insights into the functions that nov and ev aaa atpases carry out during the viral lifecycle and pave the way for the development of novel antiviral compounds capable of inhibiting these functionally indispensable enzymes
securely advancing future evs with liion batteries through optimized pathways

envisioned battery demand of 735 gwh for electric mobility by 2025 escalating to a projected 125 million electric vehicles evs by 2033 fuels our impetus for innovation however these prospects are marred by real safety concerns evidenced by 2 harrowing ship fires involving luxury evs despite adherence to the most stringent safety protocolssafeloop is a collaborative effort involving 15 entities from 11 countries representing a blend of research manufacturing and business across europe transatlantic partners are joining forces to bolster competitive materiallevel technologies and supply chain logistics key goals include securing strategic raw material feedstock reducing reliance on asian supply chains intensifying environmental sustainability optimizing energyefficient processing and demonstrating technological leadershipsafeloops focal point is gen3 eu ev liion battery lib safety encompassing the entire life cycle of libs within evs safety is considered in a broader sense not just at a cell level while the latter remains a key pillar of the research at hand to name a few material handling component processing battery manufacturing testing transport maintenance and recycling of active materials are considered a eurocentric supply chain for evgrade battery materials will be established minimizing the environmental and cost impact of longdistance transportation safeloop ensures that batteries and their components adhere to eu safety and environmental regulationsbeyond enhancing eu battery safety the project seeks to develop the worlds first evrated lib using up to 25 recycled and fully rejuvenated batteryactive materials this initiative paves the way for an ambitious industrywide recycling target of 90 within the next decade akin to todays leadacid battery industrys 95 recycling rate these ecologically responsible solutions address key aspects of automotive battery safety within the eu and beyond
coloniality and speculation in global health addressing the livedexperience of racialization among honduran lowincome urban residents through their encounters with public health services

i am applying for a 24month postdoctoral fellowship with the insituto universitrio de lisboa iscte during my fellowship i will utilize new and existing data to argue that the phenomenon known as global health should be conceived of as an additional domain for the private accumulation of capital through speculation by addressing global health as a site for speculation i intend to make evident that what appear as colonial ideological remnants in contemporary local public health practice are in effect necessary tools for the reinscription of categories of colonial difference these tools in turn facilitate processes of exploitation and alienation that allow for the extraction of value i further intend to argue that regimes of speculation in global health serve as the foundation for the coloniality of local public health practices to construct my argument i will compare data collected over the course of 28 months of mixed methods ethnographic research in honduras with new data that i will collect in the same research locales over the course of 6 nonconsecutive months of research the extended and ongoing covid19 pandemic presents an opportunity to compare previous baseline data with new information the data for this project will be collected in two neighboring cities that comprise the central district of honduras central america tegucigalpa and comayagüela the data will address the experiences and perceptions of lowincome urban populations with public health and private health services their perceptions of healthdisease processes and their perceptions of and experiences with governmental agents and institutions overall i will produce academic articles participate in professional conferences write critical popular media pieces conduct workshops with public health professionals prepare a proposal for a book manuscript write academic syllabi and design a multiyear project proposal with a honduran communitybased organization
blue bunkering of anchored ships with renewable generated electricity

the shipping industry is responsible for around 3 of global greenhouse gas emissions and this is expected to increase as global trade and shipping activity continues to grow as such reducing emissions from shipping is an important part of global efforts to tackle climate change in recent years policies and legislation mainly focusing on environmental sustainability have pushed international shipping toward the process of its decarbonization regulatory bodies are pressing on the maritime world by adopting ambitious targets and by introducing a number of initiatives that will facilitate the transition to a sustainable future including the international maritime organizations strategy to reduce greenhouse gas emissions from shipping which aims to halve emissions from the sector by 2050 compared to 2008 levelsto this end bluebarge will design develop and demonstrate an optimum powerbarge solution to mainly support offshore power supply to moored and anchored vessels limiting local polluting emissions and global ghg footprint in a life cycle perspective following a modular scalable adaptable and flexible design approach which will facilitate its commercialisation by 2030 the proposed powerbarge solution will consider different alternatives as containerised power supply modules in a variety of configurations where battery modules will serve as basis due to their high energy efficiency and readiness level and other considered modules including hydrogen fuel cells and hydrogen generators the project will address electrical integration issues interfacing challenges of the barge with ships ports and local grid operational safety and regulatory compliance aspects delivering a highreadiness and complete power bunkering solution overall the bluebarge projects full integrated system aims at contributing to the shift of the maritime industry towards the goals of electrification and decarbonisation at an eu and international level
polymerenhanced electrocatalytic co2 reduction the influence of the local ph value

the electrochemical co2 reduction reaction co2rr has the unique potential to utilize the vast carbon source co2 for production of valuable synthetic fuels being a sustainable process if the electricity is obtained from renewable energy sources several metal surfaces are known to catalyze the electrochemical co2rr however they suffer from poor selectivity and energy efficiency recently this limitation has been mitigated by functionalizing metal catalysts with polymercoatings however previous investigations are nonsystematic several electrocatalysts au cu ag pt of different morphologies bulk electrodes nanoparticles foams were combined with a variety of different polymers this renders a general view of the polymers role in electrocatalysis impossible coordinative stabilization of intermediates is the most frequently proposed origin of the performance increase however local effects like ph fluctuations were never detected this is a severe gap of knowledge considering the high ph sensitivity of electrocatalysts within pocaloph the researcher will therefore systematically investigate the influence of various polymercoatings on the selectivity and efficiency of gold and copper catalysts and will correlate these effects to local ph changes this will be realized by equipping the most efficient polymers with fluorescent ph reporters allowing for a spectroscopic ph read out the results will be systematically compared to those obtained from noncoated electrodes therefore pocaloph will create a double benefit of polymercoatings combining performance increase with valuable insights into local pheffects within the coating this will precise mechanistic knowledge on the electrochemical co2rr and may enable the rational design of polymercoated co2rr catalysts