Dragon09/odtu_chatbot huggingface dataset:
embodied imamate mapping the development of the early shii community 700900 ce

the shii imams played a key role in early islam revered scholars descended from the prophet muammad they posed an existential threat to the legitimacy of the ruling caliphs in the 8th and 9th century ce their leadership defined the quietist yet oppositional imami shii community scattered throughout the islamic empire imami shiism was a key part of the turbulent thesis and antithesis which formed islam and it remains greatly influential until today remarkably there is no comprehensive history of the imamate there are a number of reasons for this central among which are that scholarship on imami shiism has approached it as a doctrinal and intellectual phenomenon however religious groups are also fundamentally social phenomena imbod will result in the first comprehensive history of the shii imamate it will position the imamate as a social phenomenon framing it as an interaction between two aspects which are rarely explicitly theorised the imams and the imami community who recognised them imbod will identify and study the key spheres in which the imams and the imami community operated including the imams household elite arab clans especially the prophets family and the dynasties of the caliphs the network of imamic agents the scholars and the communities who came to be associated with shii islam through kinship conversion and migration imbod will map out overlapping networks of interaction across these spheres and identify key actors and institutions responsible for mediating and performing the imamate in the community imbod will not conceive of the imamate as an essence but as a set of social processes some but not all instigated and controlled by the imams themselves crucially imbod will study these processes as performed spatially and embodied materially by actors and physical objects linked to the imams imbod will enrich islamic history by providing a paradigm for studying how religious authority was embedded in society
large scale deployment project to accelerate the uptake of hydrogen trucks in europe

150 trucks from three european truck oems the volvo group daimler ag and iveco will be deployed across eight eu member states each company will develop and deploy 4144 tonne articulated trucks which are specified for the longest haul operation ranges over 600km the trucks will be deployed with over 20 truck operators and operate in a wide range conditions and daytoday operations across 8 european member statesthe trucks will operate on a new network of high throughput hydrogen refuelling stations designed specifically for trucks installed by shell omv total everfuel and linde these will be installed to cover the major tent transport corridors from north to south europe with an initial focus on the regions where the vehicles are manufactured to enable the high level of onroad support that the oems customers rely on the stations will be supplied using green hydrogen from a network of 8 new large electrolysers producing green hydrogen consistent with red ii requirements with associated guarantees of originthe project will create an extensive technical economic and attitudinal dataset which proves the viability of hydrogen as a solution to decarbonising road freight this will be analysed by research partners sintef vtt and element energy to create easily interpreted public report on the performance of the fleet the results will be disseminated to an audience of policy makers to encourage policy change to favour hydrogen truck deployment truck operators to enable future uptake and the wider hydrogen industry to underpin supply chain investmentthese activities will contribute to accelerating the rate and scale of uptake of hydrogen fuelled vehicles in europe preparing the policy fuelling network and end user acceptance for the first series production of these oem vehicles at the scale of 1000s per year per oem from as early as 2026 and full industrialisation 10000s per year per oem around 2030
the pandemic within tackling brain vulnerability in covid19 at high resolution neurocov

the covid19 pandemic has shown our health care fragility vis a vis novel pathogens with a global disruption on societal welfare despite the towering success of vaccine development lack of preparedness on integrative clinical and molecular phenotyping has emerged with clarity and highlights the need to scale translational efforts for personalized prevention and therapy of particular concern are the longterm consequences of sarscov2 infection with high and rising prevalence of chronic manifestations referred to as postcovid among these the neurological and psychiatric complications stand out for frequency lack of treatment and devastating impact of their effects at pandemic scale here we tackle the cognitive and neurodegenerative complications of covid19 referred to as neurocovid as a ticking pandemic within the pandemic that requires an innovation leap across disciplines we pursue a multi scalar approach that reaches from epidemiology and mechanistic interrogation of hostvirus interplay at single cell resolution through predictive modelling all the way to validation of biomarkers and repurposed drugs the aim is to anticipate and effectively manage personalized trajectories of neurocovid vulnerability and their impact at population level for this we leverage two leading national health registries and three clinical cohorts to characterize the phenotypic spectrum of neurocovid its risk factors and its socioeconomic burden at high definition we pioneer innovative robotics to scale brain organoid modelling and combine it with single cell multiomics and ai analytics to dissect the principles of the individual host response and render experimentally actionable the authentic genetic backgrounds of differential sarscov2 sensitivity through a substantive engagement of patients collectives and health care stakeholders upstream integration of innovative pipelines streamlines translation and operationalizes precision medicine for emerging medical needs
handson materials science for education

crystalline materials are indispensable to modern life and the development of crystal growth processes for novel materials remains an important challenge in materials science and engineering however the knowledge about these processes is limited to very select specialist communities researchers from different fields often use crystals just as products without being aware of the exciting multidisciplinary background of their production processes the handsome project aims to facilitate the integration of this topic in educational curricula at various levels we will adopt a macroscopic perspective on crystal growth starting with heat transfer phenomena and phase changes between solid and liquid states which can be related to many aspects of everyday life such as cooking or weather a modular handson setup educrys will be developed to demonstrate the growth of tin crystals from melt using a process very similar to the industrial production of silicon crystals for microelectronics various sensors will be utilized to measure the temperature or power consumption in the handsome project we envision educrys as a unique innovative educational product for both schools and universities we will follow the principles of open hardware with lowcost components and open source control software to maximize accessibility and customizability the educrys setup will allow the transfer of knowledge from hightech industries and specialized research labs to the classroom while preserving the possibility of handson experience and therefore increasing interactivity in science education the handsome project aims to reach a new level of awareness in the society about the challenges of modern materials science in particular the production processes of crystalline materials their energyefficiency and their environmental impact
future innovation for pesticide use reduction in agriculture

agricultural production largely depends on external inputs both for plant nutrition and crop in order to ensure food security while protecting the environment and mitigate climate effect agricultural production methods including the use of chemicalsynthetic pesticides needs to be revised lined out in the european green deal and the farm to fork strategy the reduction of pesticide use by 50 until 2030 should be one element to reach the expected goals in the recent years several scientific studies has been performed to develop strategies and techniques to enable a reduction of chemicalsynthetic pesticides use next to methods like organic farming which omits the use of mineral fertilisers and chemicalsynthetic pesticides but result in lower yields integrated pest management ipm has gained a lot of attention and was subject of national and international research activities advanced ipm is characterised by implementing a high degree of preventive measures to avoid establishment of pests and only resorting to chemical pesticides when there is no other option to avoid severe yield loss however the implementation of ipm at a multidisciplinary level is still lacking due to economic reasons and a low acceptance by farmers therefore a key element of fortuna is to identify and analyse the available methods tools and mechanisms from a biologicalecological technological socioeconomic perspective that unlocks a substantial reduction in use and risk of chemical pesticides and ultimately novel pesticidefree farming practices results and strategies will be discussed with stakeholders along the food and supplychain which could contribute to a transition to a reduce reliance on chemical pesticides while supporting successful yields and enable food security one major point in this process is to identify strategies that have a lower risk of productivity and profitability and profitability losses than other strategies and target the longterm perspectives
volcan activity monitoring by light cycled dynamic operation of metal oxide gas sensors

there exists a direct relation between gas emissions and earths dynamics and climate the impact of anthropogenic emissions and volcanic eruptions on the climate are well known and from the opposite the effect of the climate on the volcano activity remains mainly unexplored to develop climatevolcano models and improve eruption predictive models a comprehensive study of volcanic emissions is necessary reference measuring systems which are used by the national civil protection agencies and which one can find in the market are highly sensitive complex bulky expensive and have a high powerconsumption consequently they can only be installed in few specific locations for an accurate spatial monitor of these complex gas mixture emissions however a large number of sensing systems need to be deployed and connected providing the required ubiquity something which is possible nowadays thanks to internet of things iot usually these systems do not need to meet the sensitivity level of the reference instrumentsthe present project addresses the development fabrication and testing of gas sensors for their implementation in iot systems that will be deployed in the close vicinity of volcanoes these devices will be made from advanced and harshresistant metal oxide mox nanomaterials and will be based on an unexplored dynamic mode dm of operation in opposition to the sofar reported dm systems based on temperature pulsing here we propose to use light cycled operation lco in which a single lowpower pulsed lightemitting diode photoactivates the mox which provides the different gas response patterns required for the correct gas discrimination this constitutes an electronicnose and dramatically reduces the number of sensors and power consumption required for gas discrimination the developed devices will be tested towards gases typically emitted by volcanoes and will be benchmarked against reference measuring systems
metals against leishmaniasis

metal nanoparticles have shown high efficacy against various pathogenic microorganisms including antibioticresistant strains being a very promising solution for the development of novel therapies leishmaniasis is a neglected tropical disease caused by obligatory intracellular parasites of the leishmania genus in their human host they thrive inside the acidic environment of parasitophorous vacuole of mononuclear phagocytic cells such as macrophages leishmaniasis can manifest itself either through disfiguring skin lesions cutaneous leishmaniasis or by reaching the spleen the liver or the bone marrow visceral leishmaniasis according to the world health organization who it threatens more than 350 million people worldwide there is no vaccine and current treatments are long and difficult based on toxic expensive drugs that are becoming ineffective due to the development of resistance the metaleish project aims to develop a new treatment against leishmaniasis based on biodegradable metal nanoparticles bmps metals such as zn and mg are widely considered biocompatible being biodegradable in the human body moreover they possess antimicrobial properties and an immunomodulatory action due to their small size these particles can reach the parasitophorous vacuole of an infected phagocytic cell and kill the parasite for this purpose zn and mg bmps will be produced through the spark discharge technique then bmps aggregation in pbs or cell culture medium will be optimized if necessary through functionalization or encapsulation steps in order to achieve a stable colloidal suspension to be applied in in vitro assays lastly bmps efficacy against leishmania parasites internalized in phagocytic cells will be accessed and the mechanisms through which they are internalized by infectedmacrophage cells and exert their antileishmania action will be thoroughly described
implementing innovative methods for safety and sustainability assessments of chemicals and materials particularly at nano level in the european union

the chemicals strategy for sustainability css has been adopted which aims to tackle the challenge of producing and using chemicals to address societal needs while respecting the planetary boundaries and safeguarding people and ecosystems by dealing with pollution from all sources ec 2019 or com2019640final com2020667 final jrc report this css challenge gets operationalised through the developmentimplementation of two key ri actions 1 the strategic research and innovation plan srip and 2 the safe and sustainable by design ssbd framework consistent with the aims of the call horizoncl42023resilience0121 and bearing in the mind the pressing need to develop new methods or improve current ones to support the improvement of safety and sustainability assessments of chemicals the project implementing innovative methods for safety and sustainability assessments of chemicals and materials particularly at nano level in the european union chematsustain will not only study the quantum effects from a fundamental pointofview by dft means but also by identifying and measuring them through experimental techniques highresolution analysis xps and ups and determining the specific molecular recognition through their interaction with the environment which is a quantum mechanical effect invitro microfluidic invitro and invivo models and proteomics and transcriptomics and methods the obtained information on these descriptors will then be integrated for the development of novel in silico models for prediction ecotoxicity properties of advanced materials finally insilico model prediction results will be combined to develop a new methodology for the complementary use of risk assessment and lca to improve criteria for the ssbd implementation framework the work has been divided in eight work packages and the duration of the project is 48 months
automated zerotouch crosslayer provisioning framework for 5g and beyond vertical services

the across project designs and implements an endtoend service deployment and management platform for nextgeneration networks and services aiming at unprecedented levels of automation performance scalability and energy efficiency at its basis the platform is built as a highlydistributed grid of domainlevel orchestrators spread across multiple geodispersed and potentially heterogeneous edge environments overseen by a cloudmanaged multidomain orchestrator the use of standardised communication interfaces fosters separation of concerns events between the two orchestration layers through an integration fabric which ensures compliance with ongoing standardisation efforts the platform is further enhanced with a deep endtoend telemetry to unlock visibility of the intertwined network and compute system states b aidriven intelligence that leverages both the vast number of events originating from the dense iot ecosystem and detailed monitoring data originating from the across telemetry subsystem to generate new insights c fullstack crossdomain zerotouch provisioning via programmable hooks that exploit events originating from raw telemetry and ai processed events and d secure and trusted orchestration mechanisms for trusted computing technologies over large and heterogeneous cloudedge deployments as well as orchestration and monitoring of the security vnfsthe across concept is developed over a federated heterogeneous validation and testing environment that hosts a number of test cases and scenarios for promoting all potential intelligent and trusted zerotouch provisioning processes with different event triggering origins the test cases are carefully designed for being promoted as proof of concept poc project submissions to standards and opensource initiatives targeting but not limited to etsi zsm etsi nfvosm tmf onf
singlecell sequencing analysis of striatal gene regulatory networks in parkinsons disease

parkinsons disease pd is the fastest growing neurodegenerative disorder currently affecting an estimate of 7 to 10 million people worldwide the disease is characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of protein aggregates in the remaining ones the loss of these cells leads to a dopamine deficit in the striatum which causes the motor symptoms characteristic of pd and the general malfunction of the neuronal circuitry in the basal ganglia the existing treatment for pd is dopamine replacement therapy with levodopa this drug alleviates the motor symptoms but has a number of side effects loses efficacy with time and does not address the cognitive decline caused by pd in order to gain a better understanding of the disease and open new paths towards an effective treatment the parkseq project will use the latest advanced in singlecell rna sequencing and in situ hybridization to determine which celltype specific gene regulatory networks grns are affected by pd in the striatum to this end i will use singlecell rna sequencing scrnaseq to study postmortem human striatum samples from pd and control subjects under the supervision and guidance of ana muoz a leading expert in pd and scrnaseq studies i will draw from my experience in bioinformatics and in single cell data analysis to determine the cell types and subtypes existing in the human striatum on each subtype i will establish which genes are differentially expressed and considering their coexpression i will formulate putative altered grns then during a secondment period i will join mats nilsson laboratory to validate the scrnaseq findings using in situ hybridization dr nilsson has advanced this technique making it possible to use verify the presence of over 100 genes simultaneously on intact tissue slices this will enable me to verify the pdinduced alterations in the grns suggested by the scrnaseq data
a federated european fair and open research ecosystem for oceans seas coastal and inland waters

bluecloud 2026 builds upon the pilot bluecloud project which established a pilot cyber platform providing researchers access to multidisciplinary datasets from observations analytical services and computing facilities essential for blue science core services delivered are the federated data discovery access service ddas the virtual research environment vre and virtual labs bluecloud 2026 aims at a further evolution of its pilot ecosystem into a federated european ecosystem to deliver fair open data analytical services instrumental for deepening research of oceans eu seas coastal inland waters it develops a thematic marine extension to eosc for open webbased science serves needs of the eu blue economy marine environment and marine knowledge agendas bluecloud 2026 in 42 months covers activities at a growing number of federated environmental ris to improve optimise services for uptake of new data sets from a multitude of data originators and for discovery and access to their structured data collections the advanced ecosystem will provide a core data service for the digital twin of the ocean mobilising and making available major additional data resources as validated and harmonised insitu data by means of data lakes the modular architecture of the vre is scalable sustainable fit for connecting additional einfrastructures integrating more blue analytical services configuring more virtual labs and targeting broader groups of usersbluecloud 2026 main kers a fair compliant ddas b open science vre federating multiple einfrastructures c 3 eov workbenches d 5 virtual labs e blue strategic roadmap f dto task forcebluecloud 2026 is coordinated by the same organisations trustit maris counting on the same core team of partners cnr ifremer moi seascape belgium vliz overall it mobilises a solid multidisciplinary committed team of 40 partners from 13 eu countries
exiled empiricists american philosophy and the great intellectual migration

in the 1930s hundreds of european academics fled to the united states escaping the quickly deteriorating political situation on the continent among them were a few dozen philosophers from a variety of different schools logical empiricists phenomenologists and critical theorists especially the first group would have a tremendous impact on american philosophy although the local intellectual climate had been dictated by distinctively american traditions such as pragmatism us philosophers soon began to advance views that were heavily indebted to the empiricists thereby transforming the american philosophical landscapehistorians have reconstructed the fate of the exiled empiricists still little attention has been paid to the american context in which their movement came to full bloom this is remarkable since any account of the empiricists success requires an explanation of why the americans were so susceptible to their views what explains the surprisingly positive reception of logical empiricism and why were the americans more receptive to empiricism than to phenomenology or critical theory this project shifts the perspective from the migrant philosophers to the local philosophical climate by 1 quantitatively analyzing thousands of american journal publications and 2 qualitatively examining the archives of dozens of key us philosophers and institutionstoday it seems natural to carve up the philosophical landscape into an analytic and a continental tradition yet few philosophers realize that this deeply engrained distinction is relatively new it first became popular in the united states in the years after the intellectual migration in studying the unique american melting pot of philosophical schools eg pragmatism logical empiricism phenomenology critical theory this project offers a broader unifying perspective on 20thcentury philosophy thereby transcending the schoolbased barriers that have often shaped its historiography