Dragon09/odtu_chatbot huggingface dataset:
ultrafast laser assembly of metasurfaces with large scale fabrication capabilities

modern nanophotonic devices are redefining what can be achieved in terms of manipulating light as they provide a versatile design platform for moulding the propagation of light at will in particular freespace and integrated optical metasurfaces ms are currently offering a promising route towards the realisation of compact and lightweight optical components for sophisticated engineering of the amplitude phase and polarisation of electromagnetic waves which could ultimately replace current conventional bulky optics in a near future yet today the realisation of ms is based on the combination of precise but timeconsuming and energy inefficient nanofabrication techniques that rely on expensive and highly specialised equipment operated in strict cleanroom environments conditions which are beyond the capability of a vast majority of industrial entitiesthe main objective of metascale is to develop alternative fabrication techniques based on ultrafast laser processing ulp strategies towards the realisation of ms operating in the visible and infrared spectrum such processes will be compatible with largescale costeffective and green manufacturing routines thus appropriate for current industrial environments for this purpose metascale will specifically focus on the physical fabrication and testing of predesigned metasurfaces based on ultrafast laser assembly techniques such as direct laser writing or laser interference patterning such ulp techniques are highly versatile and repeatable in terms of surface micro and nanopatterning but at the same time require a deep understanding and careful adjustment of a broad range of linear and nonlinear lasermatter interaction mechanisms and their related timescales metascale is therefore an interdisciplinary and collaborative effort involving many scientific branches ranging from material science to ultrafast optics or computational physics
operational heathealthsocial early warning system

ambient temperatures are associated with more than 5 million annual deaths globally 300000 of which in western europe alone many european countries have implemented heat early warning systems but they are generally based on temperature thresholds from weather forecasts that do not account for the inequalities in vulnerability of the exposed populations this ercfunded project will create the first operational heathealthsocial early warning system hhsews by integrating weather forecasting environmental epidemiology and the social drivers of vulnerability towards this aim i will calibrate epidemiological models to transform biascorrected weather forecasts into predictions of health outcomes to validate the path from groundbreaking research to innovation i will analyse and compare the spatiotemporal scales of predictability and determine if the epidemiological models reduce or suppress the window of predictability of the weather forecasts hhsews will develop an operational fitforpurpose early warning system representing the health impacts of environmental temperatures which will better inform potential endusers such as public health agencies to activate emergency plans directly targeting vulnerable groups
terrorist group adaptation lessons for counterterrorism

terrorist groups find ways to adapt to changes in their environment to stay relevant and powerful this project offers new insights into this phenomenon by developing a more nuanced theoretical strategic framework and using quantitative methods to examine how terrorist groups survive and sometimes thrive despite efforts to combat them this is accomplished by integrating political psychology social movement and terrorism research and applying big data analytics and machine learning common in brain sciences natural sciences and bioinformatics to identify adaptation patterns in terrorist attack target selection and brutalityfirst this project frames terrorism as a recruitment tool for manipulating potential supporters psychological needs like vengeance repressive government actions lead to desires for vengeance and thus create opportunities for acts of terrorism specifically attacking the repressive actor to signal a terrorist groups capability for fulfilling this psychological need as such we should observe strategic shortterm changes in terrorism following government repression in the data this is tested using event coincidence analysis a method for identifying synchronization patterns and trigger rates from one event to anothersecond because terrorist groups can also adapt to changes in counterterrorism this project proposes two data collection efforts that enable big data analytics to identify adaptation patterns the first focuses on counterterrorism policies using government reports and covers a global sample of countries the second creates a novel largen crossnational counterterrorist actions dataset using natural language processing machine coding of news articles hierarchical clustering analyses will then be used to detect patterns of terrorist group adaptive behaviours and build predictive models that anticipate adaptation this has implications to improve counterterrorism and make it more proactive focused and effective
neuromodulation rehabilitation a neurofeedback and transcranial alternatingcurrent stimulation approach for the neurorehabilitation of patients with attentional deficits after acquired brain injury

acquired brain injury abi represents nonprogressive cerebral damage occurring after birth eg trauma hypoxia stroke abis affect several domains including cognitive functions specifically up to 80 of abi patients show attentional deficits that highly impact their quality of life and independence by hampering the execution of daily tasks since cognitive rehabilitation seems to be only mildly effective in treating these deficits it is crucial to explore more effective tools for neurorehabilitation among emerging techniques neurofeedback nf can effectively improve attentional abilities in patients with adhd nf is a training where a subject receives online feedback on their brainwaves with the goal to normalize brain oscillations through operant conditioning it is a promising tool for attention rehabilitation of abi patients however currently only 30 of subjects are able to master nf techniques transcranial alternating current stimulation tacs is a noninvasive electrical stimulation technique that by delivering a weak current to the brain can entrain specific frequencies in the brain thus tacs by increasing the target frequency of nf could facilitate nf and increase its effectiveness our study has 2 aims 1 to validate nf as an attentional rehabilitation tool for abi patients 2 to show that tacs can increase nf effectiveness we will perform a randomized doubleblind placebocontrolled trial with 75 subjects with abi with mixed etiologies matched by cognitive profile with 3 arms a nf alone b nftacs c control group both tacs and nf will target power we will have measures for efficacy transfer to daily life and motivation of the intervention this innovative protocol will validate a new tool for abi patients neurorehabilitation and open new doors for the combined use of nftacs in other rehabilitation fields
supporting the next generation of african experts on preventing mortality among children living with hiv through a translational training

the support project aims to strengthen health research systems in subsaharan african ssa countries affected by povertyrelated pediatric infectious diseases this goal will be achieved through a comprehensive fellowship program designed to train and mentor early and midcareer researchers the consortium comprises clinical research institutions academia and stakeholders from both ssa and europe makerere university in uganda will act as the scientific leadership hub with fellows stationed at leading ssa research institutions fostering southtosouth collaboration additionally shortterm internships at european institutions will complement their training the selection of target host countries including mozambique uganda zambia zimbabwe and senegal was based on their research capacity needs and disease burden encompassing anglophone francophone and lusophone nationsthe impact of support will be the establishment of a competent and innovative community of scientists and healthcare professionals equipped to actively investigate and address pediatric infectious diseases including epidemic management in ssa by strengthening research capacity and promoting collaboration the project contributes to longterm improvements in morbidity and mortality associated with infectious diseases in children from low and middleincome countries lmicssupport will train 8 earlycareer fellows and 5 midcareer fellows developing a new collaborative clinical study based on two ongoing edctp projects empirical and universal the fellows will undergo a rigorous training program that combines online and facetoface components to develop essential research skills this training will be integrated with their individual research projects which address critical research questions related to pediatric infectious diseases in ssa the fellows will take the lead on these projects with guidance and support from mentors affiliated with african and european institutions
extreme flood events in western mediterranean integrating numerical modelling and flood records in karst systems

changes in rainfall patterns are a direct consequence of the current climate change climate projections indicate an intensification of extreme rainfall events and floods which will directly affect social ecological and economic systems thus one of the greatest challenges of climate science is to understand model and predict the variability of floods both in temporal and spatial terms in the context of the presentday global warming nevertheless the uncertainties in projected rainfall at regional scale are still high and even higher in mediterranean areas where the climate is characterized by extreme and sudden rainfall events the instrumental record is too short to correctly estimate return floods periods thus geological records are required to better understand the longterm variability at millennial to decadal scales of natural extreme flood events among the most important flood archives including riverine and lake sediments stalagmites represent one of the best geological records ie accurate chronology wide temporal range and good preservation to study past flood frequency however stalagmites have not yet been properly exploited for this purpose modkarst will provide a unique opportunity to develop a quantitative flood database for the western mediterranean realm based on speleothems to do so the action plans to infer past flood events from the last 18000 years based on detrital layers indicative of flood events recorded in stalagmites from 5 different caves this data in combination with karst hydraulic models and waterlevel monitoring will allow to quantify past extreme flood events modkarst will help to better understand the relation among flood recurrence and climate changes and will shed light on how to better predict the variability of floods in the context of presentday global warming
landscape laboratories design strategies for sustainable and beautiful urban landscapes in the anthropocene

landlabs operates in six landscape laboratories all over europe all of which are urban landscapes characterized by heavy industrial influence its goals are the development of new theories for understanding urban landscapes in the anthropocene and new methods to design them for higher sustainability and beauty this is necessary because industrial urban landscapes are currently not appropriately recognised in terms of their contributions to sustainability and beauty the reason for this deficit is the prevalent dualistic concept of nature versus culture in western countries which sees landscapes as green natural counterparts to humanly shaped environments this concept neglects the potential of industrial urban landscapes for sustainability and beauty yet the current notion of the anthropocene as a new geologic epoch has shaken up established western concepts of nature by declaring that every cubic centimetre on the planet has been influenced by humanity there is no nature out there which is unaffected by humanslandlabs assumes that the conditions understood through the concept of the anthropocene call for new ways of understanding and designing urban landscapes in order to increase their sustainability and beauty landlabs explores new perspectives on the interconnectedness between humans animals plants water or technologies in these landscapes the young researchers in landlabs will first propose new interdisciplinary theory components second they will develop design scenarios and design strategies for the six landscape laboratory sites through an innovative researchthroughdesign approach and third they will develop new transferable design strategies for urban landscapes in the anthropocene which lead to higher sustainability and beauty landlabs offers young researchers the possibility to contribute to the highly topical issue of the green transition of cities in accordance with the european green deal and united nations goals of sustainability
probing matter at the extreme conditions with neutron stars

in this proposal we will probe the properties of nuclear matter at extreme conditions of pressure and gravity using neutron stars as astrophysical laboratories we will study different aspects of neutron starsfrom the outermost part to their dense core we will test the latest theories in nuclear physics and develop a robust understanding of its interior using the latest observational data and the results from nuclear experiments relevant to the matter of the neutron star core we will create a relativistic nuclear metamodel to model the neutron star matter that can incorporate present and future experimental uncertainties with this understanding we will use neutron stars as dark matter detectors and test theories of particle physics beyond the standard model we will predict the detectability of dark matter in future spacebased missions and gravitational wave detectors
morphogenesis meets cell fate dissecting how mechanical forces coordinate development

during embryonic development an unspecialized cell mass is transformed into complex tissues and organs through collective movements and cell interactions the acquisition of such structural and functional diversity is powered by two main processes morphogenesis which sculpts cells into tissues and organs and cell fate acquisition which assigns specific identities to cells despite extensive research the intricate coordination between these two processes remains elusive mechanical forces determine the shape and structure of tissues and their impact on cell fate has been recently uncovered emphasizing the significance of mechanics in regulating both morphogenesis and cell fate however understanding the relationship between these two processes is complex as it requires the integration of cell shape cell behavior mechanics and gene expression across the tissue over time in this project we will apply cuttingedge biophysical and data science methods to the mucociliary epithelium of xenopus embryos to dissect the role of mechanics in both morphogenesis and cell fate acquisition in vivo we will first determine how cells undergoing fate acquisition trigger local tissue rearrangements that lead to global morphogenetic movements next we will investigate the impact of tissue mechanics on cell fate and transitions finally we will combine cell behaviors gene expression and mechanics into a model to predict cell fate by exploring the ways cells respond to and modify their mechanical surroundings and the circumstances in which external forces determine cell fate we will uncover the basic principles of complex tissue formation this research will give us a comprehensive understanding of how individual cells as mechanical elements interact to form a tissue structure that is more than just the sum of its parts the findings will have a significant impact on other tissues particularly the human airways and advance our knowledge of embryonic development
revealing the landscape of synaptic diversity by cell type and synapsespecific proteomics and transcriptomics

synapses differ in their shape size and function and exhibit ongoing plasticity during the development and modification of neural circuits the structural diversity of synapses is largely known whereas the molecular diversity of synapses is much less well understood while most synaptic molecules have been identified by immunolabeling and bulk proteomic approaches the complement of proteins present at individual synapse types as well as their stoichiometric relationships with other molecules remains unknown indeed our current classification mostly relies on neurotransmitterreceptor phenotypes leading to broad descriptors like excitatory or inhibitory synapses because the function of the synapse as well as its ability to change is largely determined by the quality and quantity of molecules that inhabit it it is essential to understand synaptic molecular diversity the aims of this proposal are to determine the proteomes and transcriptomes of geneticallyidentifiable synaptic populations in different brain areas and to determine the molecular diversity in these same synapse populations using transcriptomic analysis of individual synapses we will also assess how these synaptic proteomes transcriptomes and the transcriptomic diversity respond to plasticity to study synaptic proteomes and transcriptomes we will use fluorescenceactivated synaptosome sorting to purify different synaptic populations excitatory inhibitory dopaminergic from different brain areas we will use the stateoftheart methods optimized for quantitative transcriptomic and proteomic profiling of very small amounts of sorted synapses and develop a method syndrops for the transcriptomic analysis of individual synapses we will examine how synaptic proteomes and transcriptomes change during plasticity these studies will reveal the landscape of synaptic diversity within synapse types and across brain areas and allow the field to probe diseased synapses in the future
circular biobased technical textiles with innovative bioinspired nontoxic functionalisation

eus industry is pushed by ecs green deal to convert into a netzero industry accelerate the transeus industry is pushed by ecs green deal to convert into a netzero industry accelerate the transition to climate neutrality and drive its resilience as an important part of the eu manufacturing industry the eus textile sector is thus called to action and to reach the next level of disruptive innovations in sustainable textiles biofibreloop is a businessdriven consortium of 12 partners from small to large industry and scientific institutes and will meet these challenges by deploying a new generation of renewable recyclable bioinspired materials made of lignin cellulosic and polylactic acid at trl 7 by 2027 the innovation addresses the outdooractiveworkwear industry and will result in circular technical textiles made from biopolymers with innovative bioinspired nontoxic functionalisation biofibreloop will demonstrate breakthrough technologies and pave the way for market entry i near to zero waste biomimetic functionalization through circularity ii zero use of hazardous chemicalsiii satisfied consumer needs through smart functionality for hydrophobicity oil repellency selfcleaning and antibacterialityin 3 industrial demo sites it de at biomimetic functionalisation and recycling of the biobased materials will be proven at large at trl7 these are based on processes owned by partners and brought in at trl4 eg ligninbased thermoplastic coating laserbased technology for surface structures in biobased textiles thermomechanical recycling of pla and ligninbased textile materials to serve as valuable secondary raw materialsat the projects end a patented circular sustainable and safe process will be validated and demonstrated at a large scale to generate brandnew renewable recyclable and functionalised materials by 2035 20 of the textile industry will adopt our solution boosting 950 mio additional revenues
intelligent encapsulation and screening platform for precision delivery of probiotics to improve gut health

over the past century drastic lifestyle changes have caused disbalanced gut microbiota which has been linked to various health conditions and noncommunicable diseases probiotics are a promising route for restoring a healthy gut microbiome but their inherent sensitivity towards oxygen water heat andor gastric acid greatly hampers their widespread application in disease prevention and treatment programs insight solves this longstanding challenge by realizing precision probiotics via a novel and disruptive microencapsulation approach we set ourselves the goal to investigate and develop a tunable microcapsule formulation and scalable encapsulation process for the protection and targeted poststomach delivery of sensitive probiotic formulations specifically we will work on unique bigelbased microencapsulation formulations that are expected to provide unsurpassed protection to probiotics to study the structural breakdown of capsules and thereby the controlled release of probiotics we will develop and test a novel gutonachip microfluidic device to obtain more indepth knowledge as well as prepare for highthroughput screenings we incorporate machine learning for i automated investigation of digestion kinetics under personalizable conditions and ii automated inline identification evaluation and adjustment of microcapsule synthesis as a proof of concept we will leverage our encapsulation and screening platforms to protect a sensitive nextgeneration strain and make our precision probiotics formulation available to patients via personalized treatment of a patient cohort under pharmacy legislationinsight forms the basis for protection and delivery of sensitive probiotic ingredients and thereby contributes to the prevention alleviation andor treatment of myriad health conditions related to unhealthy gut microbiota
a computing unit for autonomous spacecraft guidance in deep space

the space revolution is expected to become the biggest industry in history during the last decades space exploration has contributed to the development of various technologies eg gps weather predictions solar cells reliable power grid earth observation services that fedback into the economy and improved our lives in 2020 the global space economy was valued at about 4469 b with the advent of deepspace cubesats nanosatellites that disrupted this industry space agencies are planning to launch tens of cubesat in deep space per single launchthe number of deepspace probes is bound to thrive yet their growth is unsustainable with current practice humanintheloop operations are particularly relevant for flightrelated procedures in cruise phase the spacecraft position is determined from ground with a consistent involvement of resources and assets it is acknowledged that a sustainable deepspace exploration requires enabling selfdriving spacecraftthe guido project forges an autonomous guidance board to enable the selfdriving capability of spacecraft in the solar system the project stems from the ercfunded project extrema erccog2019 guido aims to elevate the convexoptimizationbased guidance algorithms conceived within extrema to a proofofconcept board at trl 4our autonomous guidance board guidoboard is a disruptive innovation that will change the modus operandi of deepspace satellite operation guido will revolutionize the way spacecraft travel in space by cutting the cost of ground control of the whole cruise phase and unlocking the new space mission conceptthe project follows a suitably devised pathway to cover technical validation activities and assessment of exploitation opportunities guido has raised the interest of leading sectoral players and space agencies as witnessed by the letters of interest attached