Dragon09/odtu_chatbot huggingface dataset:
anger legitimised angle amplified anger and its rhetorics of legitimation in the 21st century

the world is an increasingly angry place fueled by economic turmoil conflict climate collapse and culture wars outbursts of collective anger are visible online on the streets and in various political forums these outpourings of visible collective ire what we call amplified anger have been historically condemned in mainstream public discourse as antidemocratic uncivil attacks on human coexistence but for the people engaged in these acts of rage anger is often seen as a fully legitimate necessary response to injustice oppression or crisis there is an urgent need to study the sources and rhetorics of legitimation that allow this amplified anger to flourish be voiced and spread within and across contemporary communitiesangle anger legitimised will study how communities that feel their anger has been delegitimised seek to perform communicate and justify this volatile emotion composed of four interconnected work packages fury venom rage and wrath the project will explore gendered postcolonial postconversion and neo religious iterations of anger in specific cultural sites across the globe it uses a novel twofold methodology fieldwork and participant observation to access and study the localised anger worlds of particular communities and textual analysis to study print and online spaces where discourses of amplified anger intermingle to create wider transnational anger arenasangles analytical framework will provide critical empirical insights into the dynamics of global political action through the innovative concept of the grammar of anger we will compare the legitimation transmission and ethics of amplified anger across local and global political sites we will advance eus research environment by consolidating empirically informed anger studies building an international consortium of anger scholars and creating a significant repertoire of knowledge on the economic cultural and political impact in the 21st century
investigation of affective input during object encoding in the perirhinal cortex

in our everyday life we ascribe certain emotional value to some objects more specifically we ascribe a valence to some objects which is the degree to which something can be pleasurable or averse leading to an emotional response when we interact or remember them in the act of learning and remembering an object the brain executes a complex set of operations integrating multiple sensory inputs vision smell touch sound etc and the corresponding valence of the object to generate a unique mental representation used to recognize and distinguish one object from another this is known as object encoding there is plenty of evidence linking the activity of the main hubs of emotional information processing amygdalar nuclei and object encoding in the brain perirhinal cortex but a precise description of how notions of valence are incorporated during object encoding have not been investigated in part due to the technical challenges involved emotionobjectcoding will make use of neuropixel a powerful and new technology enabling for the first time the recording of populationlevel activity with high temporal resolution this approach will be complemented with in vitro electrophysiological and optogenetic tools providing a precise description of the neural circuits involved in the incorporation of valence during object encoding taken together these innovative methods will provide the groundwork for developing new hypothesis for the role of affective input during object encoding furthermore this project will contribute to create a clearer picture about how our emotional wellbeing affects other important cognitive processes such as learning and potentially disorders such as ptsd and alzheimers disease
modelling african futures a comparative technography of evidencebased welfare policy in ghana senegal kenya and botswana

welfare systems rely on extensive knowledge about the population to plan finance and expend limited resources in a targeted manner in view of their oftenfragmented national identification and statistical systems africas emerging welfare states are thus facing significant challenges in their capacity to establish categories of welfare entitlement and to target groups for intervention led by the pi modelfutures team will carry out groundbreaking comparative ethnographic research at the statisticswelfare nexus of four african country cases ghana senegal kenya and botswana to understand how do states generate truths about future welfare in contexts of uncertain knowledge about the population and its wellbeing the projects threefold objectives aim to 1 trace statistical modelling practices in the context of multifacetted uncertainties about the population and its environs 2 analyse the impact of adaptations and creative data practices on quantitative truth claims and 3 connect statistical futuremaking and anticipatory welfare politics in sites of statistical innovation modelfutures ambition significantly extends beyond the state of the art of our understanding of statistical worldmaking by developing a novel concept of vernacular prediction that attunes to experts skilful adaptations of globally circulating computational models and standards while attending to their modelling practices coconstitution with symbolic commitments and situated infrastructural arrangements combining expertise from anthropology science and technology studies and population statistics modelfutures generates novel theory on the production of evidencebased welfare policies in contexts of contested claims to the validity of data methods and the anticipatory politics that play out between shortterm mitigation efforts and the pursuit of longterm dividends
identification of novel targets to improve glioblastoma therapy

glioblastoma gbm is the most common malignant primary brain tumour in adults the current standard of care is surgical resection of gbm tumours followed by chemotherapy and ionizing radiation ir despite these intense efforts gbm tumours remain incurable and the median survival rate of gbm patients remains only 15 months this dismal clinical outcome underscores the urgent need for novel therapeutic strategies for gbm at the cellular level gbm tumours contain a rare population of selfrenewing highly invasive stem cells termed brain tumour stem cells btscs btscs are endowed with properties to proliferate spur the growth of new tumours and at the same time evade ir and chemotherapy thus eradicating btscs in tumour bulk represents a promising approach to fight brain cancer at its roots however there are presently no treatments targeting btscs in gbm recent preliminary data obtained by the applicant led to the hypothesis that a novel signalling pathway controls btsc behaviour and represents a promising target to eradicate btscs thus the applicant will join the bordeaux institute of oncology bric at university of bordeaux to test this hypothesis under the supervision of pr bikfalvi the host the supervisor and the candidate represents the perfect match to realise this proposal the project is designed to bring forth a twoway transfer of knowledge between the host and the candidate the advanced techniques and transferable skills that the candidate acquires through this research will largely broaden his competencies and increase his employability as an independent researcher in the field of neurooncology results generated through this proposal will be innovative and of clinical relevance for gbm patients this study has the potential to open new therapeutic avenues and pave the way for future clinical trials for better treatment of these deadly tumours
design manufacturing and validation of ecocycle electric traction motor

as a response to the need to decrease the transportation related emissions and energy consumption today all major passenger car and other lightduty vehicle manufacturers are broadening their electric vehicle portfolio the dependency of the present electrical traction motors on the rare materials such as rare earth permanent magnet materials namely neodymiumironboron magnets is problematic from several viewpoints they are imported and expensive and there is a real risk for supply problems in the coming years to strengthen the european competitiveness voltcar design manufacturing and validation of ecocycle electric traction motor proposes highspeed permanent magnet assisted synchronous reluctance technology with a drastic reduction in rare materials utilisationduring voltcar the motor prototype is perfected to meet the strictest performance requirements power density efficiency sustainability criteria recyclability circularity and low use of rare resources and copper and the expectations of the automotive sector cost reliability integrability this major goal is supported by introducing digital design and optimisation methodologies that are capable of assessing the life cycle costs energy consumption and carbon footprint in the early phase guiding the outcomes towards maximised sustainability with reduced use of rare materials and efficient recycling and repurposing patterns the validity of the voltcar motor prototypes 50 kw and 120 kw motor and related technologies is proved according to the automotive standards presenting an xintheloop xil experimentation environments with this development voltcar will simultaneously lead to more green jobs in local smes throughout europe to reduce unemployment ratethe voltcar consortium comprises worldleading automotive tier 1 and tier 2 companies and research partners with complementary knowledge and expertise for the successful execution of the proposed work
interactive fluidic state machines for soft robotics

actuation energy storage sensing and logic are four functionalities of both natural and artificial organisms giving them the ability to thrive in their environment the blueprint of conventional robots localizes these functionalities in discrete components supported by rigid materials however in soft robots that consist of compliant materials localization of functionality severely limits autonomous operation and intelligent behaviour this limitation is the result of the functional architecture not of the used materials alternatively and as demonstrated in nature by the common octopus the distribution of these four functionalities throughout the body allows to overcome these limitations this concept of functional embodiment is currently nonexisting in soft robotics ilumis will create soft robots with embodied functionality by transitioning from a conventional robotic architecture to a fluidic network architecture further by incorporating nonlinearities in all the network elements the global system acts as a state machine meaning that the output not only depends on the input but also on its internal state how to navigate this state space will be encoded within the nonlinearities creating embodied logic energy and actuation are embodied and intricately linked to the elastic deformations of the components in the network powering the actions of the soft robot by creating network components that are sensitive to triggers from the environment embodied sensing emerges leading to truly interactive fluidic state machines ilumis will overcome the main challenges of inverse design where a desired behaviour requires the optimization of a network of nonlinear structures thereby ilumis will create a new blueprint for soft robotic design with embodied functionality that closes the gap with natures soft organisms this knowledge will impact applications ranging from surgical microrobots and exploration robots to haptic interfaces for virtual reality
hyperaccumulatorgrassderived antibacterial boronfunctionalized carbon dots synthesis and cytotoxicological evaluation

the antibiotics overuse exerts selective evolutionary pressure on microbial pathogens leading to the emergence of resistant strains to reduce the likelihood of future epipandemics of bacterial origin it is thus essential to put alternatives in action and consume antibiotics more sparingly while the heavy metalbased antimicrobial agents are convenient for some uses they bring human and environmental toxicity issues and suffer from microbial resistance with their potentially low risk of resistance development carbonbased nanomaterials seem like promising substitutes carbon dots cds are particularly interesting owing to their small size good solubility and relative affordability and borondoped cds bcds deserve even greater attention as they typically show high antimicrobial activity however our current understanding of the toxicity profile of bcds is fragmented and limited to materials synthesized by small molecular synthetic precursors as carbon and boron sources in the project hyperabcd we will first show the hydrothermal conversion of a boronhyperaccumulator plant biomass into bcds then we will explore the antibacterial activity of bcds on gramnegative and grampositive species using various bacterial susceptibility tests next we will undertake toxicological evaluations at different levels to this end we will perform standard viability tests with various human cell lines as well as a mutagenicity test the assembled research team is fully competent to realize the ambitious goals of the proposed crosseuropean effort i am a multidisciplinary researcher specializing in antimicrobial nanocarbons the primary host dr alberto bianco cnrs institute of molecular and cell biology is among the pioneers of biomedical nanocarbon research and our cohost prof tom coenye ghent university is a renowned expert on microbiology our industrial partner pavtec turkey is a leading company in developing boronbased specialty chemicals
uncovering hidden structures in protein crystallization with coherent xrays

diffraction and serial crystallography serve as essential tools for comprehending the functions and dynamics of proteins however a significant limitation to their application lies in the consistent generation of protein crystals thus it becomes imperative to explore novel avenues that can facilitate and regulate protein crystallization classical nucleation theory does not encompass the crystallization pathway for numerous protein solutions this proposal seeks to offer fresh experimental insights into hidden intermediate metastable structures that are hypothesized to occur during the observed anomalous crystallization mechanism our objective is to explore in a nonequilibrium manner the anomalous crystallization of ferritin solutions in microdroplets and characterize its time evolution the latter is going to be accessed via xray photon correlation spectroscopy xpcs which will reveal the dynamic properties of both proteins and the amorphous phase that precedes crystal formation additionally we aim to quantitatively assess the role of water in this system pertaining to proteinprotein interactions hypothesized to depend on the water structuring in the vicinity of the interacting surface capturing the desolvation process is crucial for the understanding of the molecular mechanism underlying the different crystallization pathways since it has been hypothesized that the efficiency and directionality of the desolvation leads to a higher classical or lower nonclassical degree of protein ordering in the initial aggregates the candidate has a strong background in experimental methods sensitive to protein dynamics and joins the host group which specializes in water experiments with microdroplets the project utilizes the unique coherent properties of european large scale facilities such as the european synchrotron radiation facility esrf and european xray free electron laser euxfel
freight volumes transfer from road to waterborne transport using zeroemission automated small and flexible vessel prototypes

foremast ri activities are structured along 4 ambition pillarsp1 selectable level of automation guidance navigation and control gnc architecture and interfaces and situational awareness model for interfacing gnc and sensory hardware and processing systems to efficiently solve the control problem unique to iwt combined with balanced humanautonomy collaboration navigation mooring cargo handling propulsion and safety implications in mixed traffic utilising tailored galileoegnos services will lead to a nextgeneration remote control centre trl 5 and small flexible automated zeroemission sfaz autonomy control system trl 5 protypes p2 zero emission energy management solutions dynamically optimised for prevailing operating conditions hybrid electric and fuel cell zero emission solutions will be evaluated against power and energy requirements lifetime costs and lifecycle emissions of alternative fuelenergy systems p3 innovative macro designs for sfaz vessels in intramodal intermodal transport networks reflecting innovations from p1 and p2 vessel design concepts verified through simulation will provide systematic evaluation of sfaz designs for confined areas and shallow waters providing an increased operational flexibility in terms of cargo capacity types and load units tied with hydrodynamic and propulsion models and control architectures p4 a modelling simulation design and operational optimisation tools digital twining platform enables both design and operational measurement and optimisation of living lab ll solutions supporting solutions for european coastal and inland or congested urban regions incorporating if needed third party innovative components ensuring transferability and sustainability 2 lls in ghent and caen that represent coastal and inland congested urban regions will demonstrate the sfaz prototypes integrated through automated smart terminals in optimised logistic networks a 3rd virtual ll in galati will demonstrate replicability
bridging the research and innovation gap for rare diseases in europe by upgrading excellence of imgge

there are over 330 million people living on the planet affected by one of over 6000 identified genetic rare diseases rd they urgently need timely diagnosis and development of specific treatments although europe leads the way in rd research there is a clear gap in research and innovation ri between countries to bridge this gap networking and knowledge sharing between imgge institute of molecular genetics and genetic engineering serbia and 3 worldclass counterparts at eu level ki karolinska institute sweden cnag national center for genomic analysis spain and uam autonomous university of madrid spain is envisioned bridgingrds objectives are 1 upgrade the imgge rd biobank to reach full interoperability of genetic and phenotypic data in order to increase participation in transnational research and innovation projects related to human health 2 upgrade bioinformatics pipelines specific to rd to increase the rate of solved rd cases in imgges rd biobank 3 upgrade capacity for modelling of metabolic diseases as well as capacity to test small molecule drugs in order to increase the number of translational studies 4 upgrade research support offices in order to increase success in obtaining funds from research andor innovation agencies industry foundations etc objectives will be achieved through staff exchanges expert visits trainings or workshops conference attendance joint summer schools and disseminationoutreach activities crucially an exploratory ri project engaging all partners will focus on identifying an innovative drug pharmacochaperone for a selected metabolic rd bridgingrd will have impact by significantly improving the scientific excellence and innovation capacity of imgge raising its research reputation and research management skills it will also impact networking and mobility of qualified scientists in the rd field thus boosting creativity and ultimately enhancing economic growth at the european level
novel apamerbased rapid test technology for virus detection

rapid care tests and patientoriented bedsite testing termed as point of care poc testing have proven unanticipated relevance for the fast detection and containment of the pathogen in the course of the corona pandemic we have developed rna aptamer based sensors as a basis for a novel rapid care test the sensor will give a florescent signal once the target molecule attaches to its aptameric site the sensor as the main component of a novel poc test will be produced by a cheap and scalable biotechnological synthesis the unique selling points of our invention are the cheap and scalable production of the sensor molecule and the high flexibility in terms of analytes that can be covered by aptamersto proof our concept and to demonstrate the applicability of our aptamer sensors we will choose the avian influenza virus as an use case based on the high relevance of this disease in veterinary medicine and its perception as a high risk disease for the next human pandemic our test will comply with the assured criteria of the who affordability sensitivity specificity user friendliness rapid and robust equipmentfree and deliverable to endusersour aim is to establish a rna aptamer based sensor as a basis for a cheap singleuse test according to the assured criteria in this action we will establish the applicability of our highly sensitive and selective rna based sensor we will devolop a prototype of a poc test and test the novel sensor principle under laboratory and environmental conditions in addition we will analyse the market and patent situation and the stepstones to be taken for an approval by the european authorities we will finally establish our own ipr position as a basis for the further roadtothemarket
detecting the right moment to do embryo transfer in in vitro fertilisation treatments

invitro fertilization ivf is a wellknown fertility treatment used for infertile couples single mothers and women in samesex relationships of the nearly a million ivf cycles done in europe annually 3 million globally only 40 result in pregnancy low ivf success makes the process long expensive and emotionally devastating moreover the dissimilar access to fertility treatments contributes to health inequity and gender imbalance as infertility is still a womens social burdenone of the leading causes of ivf failure is embryo transfer et with live birth rates etlbr below 30 and lower than 10 in women around 40 years old the main factors affecting etlbr are embryo quality uterine receptivity and embryouterine synchrony nowadays the selection of highquality embryos is solved but in the presence of highquality embryos the uterus determines the success of embryo implantation however assessing the uterine readiness for embryo transfer is done by counting daystherefore an urgent unmet clinical need is to provide accuracy in detecting uterine receptivity and embryouterine synchrony to improve embryo implantation rates and ivf successwe have created seedchrony a pointofcare device that detects endometrial receptivity noninvasively and instantly enabling rightontime embryo transfer to boost ivf success unlike the standard of care counting days and the current solutions tissue analysis requiring tissue biopsies and time for sample processing seedchrony is accurate the measurements are done directly in the uterine fluid and the results are immediate allowing doing test and transfer on the same daymanina medtech is a preseed stage startup with a b2b business model and the vision that every woman who goes through ivf requires a single ivf cycle to get pregnant we position to fundamentally boost ivf success making the whole process faster healthier and more affordable