Dragon09/odtu_chatbot huggingface dataset:
radial glia as neurodevelopmental mediators of gut microbiota signals

brain development is an intricately orchestrated process that is sensitive to the influence of peripheral processes one such peripheral factor known to have multiple roles in host physiology is the gut microbiota the ecosystem of symbiotic microorganisms that populate our gastrointestinal tract disruption of the gut microbiota has been associated with neurodevelopmental and neuropsychiatric disorders however the mechanisms through which the gut microbiota could influence brain development and thus potentially lead to cognitive and behavioural deficits remain to be elucidated radiogut aims to mechanistically understand the interactions between the gut microbiota and brain neurodevelopment at molecular and cellular levels to accomplish this we will employ distinct models of earlylife microbiota disruption in mice and assess the impact on neurodevelopment combining explant cultures with microbial metabolites and an integrated multiomics analysis we will identify key microbial metabolites that modulate neurodevelopment discern their signalling mechanisms and their potential to rescue neurodevelopmental deficits as well as later life aberrant behaviours radiogut will explore for the first time how the primary neural stem cells in the brain the radial glia can act as cellular sensors of microbial signals that modulate neurodevelopment it will fill a large gap in the understanding of microbiotagutbrain axis development and its communication code as well as deliver tangible future translational value
silicon brillouinassisted optoelectronic oscillator based on subwavelength membranes

siliconbased technologies offer tantalizing prospects for lowcost mass production of highperformance optoelectronic circuits by leveraging the maturity of complementarymetaloxide semiconductor facilities however the processing and generation of highquality radiofrequency signals using optoelectronic oscillators is still hampered by the spectral response of si filters which are unable to provide a rejection band on the order of mhz stimulated brillouin scattering sbs has been at the core of recent stunning demonstrations of key onchip functionalities for microwave photonics exhibiting several properties that are ideally suited to overcome the limitation of si photonic filters sbs interactions can be orders of magnitude stronger in suspended si waveguides compared to conventional optical fibers but approaches demonstrated so far are mainly limited by tradeoff between phonon lifetime and photonphonon overlapthis project will address a completely new route to overcome the tradeoff between long phonon lifetimes and large photonphonon overlap in conventional si optomechanical waveguides the original idea is to exploit the unique degrees of freedom released by subwavelength si nanostructuration to achieve flexible control of the shape and dispersion of optical and mechanical modes in order to maximize optomechanical coupling and brillouin gain this approach will be used to demonstrate a si optoelectronic oscillator that exploits the intrinsic narrow linewidth of the brillouin effect to achieve three orders of magnitude phasenoise reduction compared to the state of the art the sunrise technology will open a whole new research domain in integrated optomechanics with great opportunities for fundamental and applied research the unique expertise combination of the experienced researcher the host institution and the two teams hosting secondments offers all the ingredients to significantly contribute to the next generation of microwave photonic systems
a european shield against colorectal cancer based on novel more precise and affordable riskbased screening methods and viable policy pathways

with colorectal cancer crc being accountable for 124 of all deaths due to cancer and with only 14 of eu citizens participating in screening programmes there is an urgent need for accurate noninvasive costeffective screening tests based on novel technologies and an increased awareness on the disease and its detection furthermore personalized approaches for screening are needed to consider genetic and other socioeconomic variables and environmental stressors that lead to different onsets of the disease oncoscreen responds to these challenges by developing a riskbased populationlevel stratification methodology for crc to account for genetic prevalence socioeconomic status and other factors it complements this methodology by a developing a set of novel practical and lowcost screening technologies with high sensitivity and specificity b leveraging ai to improve existing methodologies for crc screening allowing for the early detection of polyps and provision of a personalized risk status stratification and c providing a mobile app for selfmonitoring and crc awareness raising furthermore oncoscreen develops an intelligent analytics dashboard for policy makers facilitating effective policy making at regional and national levels through a multilevel campaign the abovementioned solutions are tested and validated for the clinical solutions specifically a clinical validation study has been planned with the participation of 4100 enrolled patientscitizens to ensure the adoption of the developed solutions by the healthcare systems their costeffectiveness and financial viability will be assessed the 48months duration project will be implemented by a multidisciplinary consortium comprising of 38 partners including technical solutions providers hospitals ministries of health as policy makers legal and ethics experts insurance companies involving actively enduserscitizens in all phases of implementation through targeted workshops this action is part of the cancer mission cluster of projects on prevention including screening
crossborder hydrogen valley around the baltic sea

balticseah2 will establish the first largescale interregional hydrogen valley in europe balticseah2 will build a main crossborder hydrogen valley between finland and estonia and connects it with local valleys in different countries surrounding the baltic sea the ultimate goal is to develop an international hydrogen economy and markets that work optimally both from the technical economic and environmental perspectives across country borders in the northern europe more specifically around the baltic seathe project will develop scale and demonstrate hydrogen use in production storage and distribution and in use cases in different sectors from industry mobility and energy the learnings from the crossborder buildup of a hydrogen economy will be shared with specifically identified connected valleys and replicated across borders between them but furthermore shared to boost replication and initiate new hydrogen valleys across europethe cross border main valley is to be located in the region of southern finland estonia these regions are already connected with a natural gas pipeline transmission cable and maritime operations and the transmission system operators tso in both countries collaborate actively in the further development of the cross border infrastructures the cross border nature of the main valley makes is possible to develop cross border markets and businesses for green hydrogen production transport and use from the start including also development of cross border neighbouring pricing zones for renewable electricity to reach optimized system market and business designs for an efficient hydrogen economy
digital twin of earth system for cryosphere land surface and related interactions

to guide climate change adaptation and mitigation reliable information on the regional and local impacts of climate change is needed the destination earth destine initiative responds to this need by developing digital twins dts of the earth in particular destine climate dt provides climate information at regional and local scales over multiple decades however the reliability of the impact assessments of climate dt depends on the underlying kmscale climate models which fail to represent some key components of the earth systemwe aim to enhance the destine infrastructure by developing a digital twin of the earth system for the cryosphere land surface and related interactions terradt terradt subscribes to the destine vision of building interoperable and interactive dts while pushing the resolution to kmscale globally terradt improves the descriptions of earth system components in the destine climate models for land ice sea ice aerosols and land surface terradt is based on a modular infrastructure with a coupling interface that enables adding new components or aimlbased emulators terradt also develops impact models linked to the cryosphere and land surface to provide userrelevant information with interactive capabilities terradt developments enable their full integration to the destine framework overall terradt will improve the reliability and relevance of the climate projections and impact assessments of destine which is critical for guiding adaptation and mitigation actionsthe terradt consortium consists of 18 organisations with expertise in earth system modeling supercomputing and impact assessments terradt will also engage with relevant users and stakeholders the consortium includes the key partners from the destine climate dt contract team thus it is in a unique position to fully exploit the novel approach of climate dt and further enhance its capabilities by integration of the terradt developments
landscape resilience knowledge alliance for agriculture and forestry in the mediterranean basin

the objective of the resalliance is to facilitate information and knowledge flow and increase the awareness understanding and capacity of farmers and foresters on landscape resilience in mediterranean countries more specifically resalliance will gather and assess knowledge and practice needs gaps barriers solutions and good practices to achieve resilient landscapes with special emphasis on measures against hazards caused by climate change it will also prepare and facilitate stakeholder engagement through interactive and innovative participation methods it will finally transfer the knowledge and activate regional landscape resilience governance with special emphasis in five mediterranean regionsresalliance will create and animate a mediterranean thematic network on landscape resilience landnet for forestry and agriculture the landnet will continuously identify engage and grow new cooperation and networks to access improve and increase the knowledge of solutions and good practices the landnet will prepare the contextspecific knowledge and engage and train farmers foresters and other key stakeholders for knowledge transfer of managerial technological financial or governance solutionsthe work programme will allow capturing and interpreting most urgent needs while identifying and coupling unknown best practices in research and practice with these needs compiling a comprehensive description of the state of current farming and forestry practices on landscape resilience to summarise and explain the addedvalue the relevance and the costbenefit aspects of the practices collected avoiding duplication delivering an extensive range of useful applicable appealing and easytoaccess material in many formats including eipagri eu farmbook and existing dissemination channels most consulted by farmers and foresters in the countries and building synergies with ogs and innovation groups from eipagri and implement multiactor approach
mapping of longitudinal data of inequalities in education

the mapie project aims to identify mechanisms causing educational inequalities and policies or interventions compensating for them we do a systematic review of how these have been studied internationally using longitudinal designs we map existing longitudinal data that we describe in a public metadata database and we analyse them to describe the mechanisms of inequalities and to identify effective policies and interventions in different local contexts we focus on the contextual differences between the nordic and central european countries that have structurally different education systems within national contexts and using comparative research designs we look at system regional and schoollevel policies and practices and individuallevel factors eg socioeconomic status immigrant background gender special educational needs that are associated with the development of educational inequalities and the successful prevention of achievement gaps we publish and disseminate the empirical results of the project through multiple channels to scientific audiences policy makers and the wider public at the end we create a public framework for studying educational inequalities longitudinally in future studies acknowledging the role of local contexts but aiming for comparability at the european level we implement the project in seven work packages our consortium consists of internationally acknowledged experts in largescale educational assessment research from finland sweden norway hungary and luxembourggermany the partners have a longstanding history of collaboration with each other european researchers and national and international education policy makers and they bring extensive longitudinal datasets to the project the project will considerably strengthen the knowledge base of what shapes educational outcomes over time how to best support the learning of all students and how to reduce education inequalities in the short medium and long term
verb valency in germanic diachronic analysis and reconstruction of protolinguistic scenario

verbal valency is the number of core arguments a verb can take hence instantiating a particular valency frame there are for instance zerovalent verbs eg to rain eng it rains monovalent verbs eg to sleep eng i sleep bivalent verbs eg to kiss eng the girl kisses the boy trivalent verbs eg to give eng the boy gives a present to the girl etcthe present projects overarching aim is to map out and analyze the valency patterns of germanic this is done by selecting a number of representative language varieties within germanic gmc and by tracing the evolution and variation of valency patterns for a selection of verb meanings following the methodological golden standard set out by the valpal project the toberesearched languages are gothic east gmc english german dutch and frisian west gmc icelandic and swedish north gmcthe present project contributes to advancing that methodology and it is inscribed in the research activity carried out by the pavia linguistics team within the pavia verbs database project pavedathe overarching aim of my project is made up of the following objectives 1 gather all elicited data in a digital resource 2 pursue a diachronic analysis of valency patterns within the history of single languages 3 carry out a synchronic analysis of valency patterns in the germanic languages at different language stages and hence 4 reconstruct valency patterns of germanic in prehistoric timesthe most relevant direct outcomes of the project are 1 make the data available to other researchers 2 contribute to the actual research in diachronic morphosyntax 3 expand the paveda database with diachronic data for germanic and hence 4 establish a welldefined benchmark within the addressed research area by implementing a standard tool designed at the host institution
a pointofcare serological rapid diagnostic test for risk of plasmodium vivax hypnozoite infection pvserordt

plasmodium vivax is considered the most difficult species of human malaria parasite to eliminate because of the inability of conventional diagnostics to detect individuals who carry dormant liver forms and sustain malaria transmission the consortium has developed the first diagnostic test that addresses this problem pvserordt aims to develop a pointofcare poc rapid diagnostic test rdt to transfer the consortiums validated labbased test to the field to support implementation of the p vivax serological test and treatment pvserotat malaria control strategy the pvserordt specific objectives are 1 develop a poc rdt using lateral flow technology to measure antibodies to four p vivax proteins that are biomarkers for the dormant liverstage of p vivax 2 establish africabased manufacturing capacity at diatropix senegal following rdt development at abingdon health a ukbased sme specialising in lateral flow assays3 validate rdt performance with biobanked samples followed by fieldbased clinical validation on freshly collected samples in ethiopia and madagascar4 develop a clear regulatory strategy to streamline market authorization and access to this firstinclass p vivax serological testing pvserordt addresses all expected outcomes and impacts of this call topic and work program respectively specifically it will contribute a robust poc diagnostic to the pipeline in subsaharan africa ssa and enable the implementation of the aueu innovation agenda for public health the project is designed to address the whos preferred profile for p vivax diagnosis to translate an sme prototype to africabased industrial design and to test clinical performance in several ssa sites thus enhancing international cooperation in ssa and improving training opportunities in ssa ultimately pvserordt will facilitate implementation of pvserotat a new intervention for malaria elimination
proteomics of neuroinflammatory signaling illuminating cellular mechanisms driving neurodegenerative diseases

alzheimers ad and parkinsons disease pd are prevalent neurodegenerative diseases but their underlying mechanisms remain poorly understood emerging evidence suggests that neuroinflammation characterized by the release of proinflammatory cytokines like il1 tnf and inf plays a pivotal role in these diseases challenging the conventional focus on protein aggregates a syn in ad it has been shown that elevated il1 levels induce the translocation of nedd8 from the nucleus to the cytoplasm where it colocalizes with the e3ligase parkin together with the kinase pink1 parkin is crucial for the removal of defective mitochondria with lossoffunction mutations in these genes being the primary cause of earlyonset pd intriguingly phosphorylated nedd8 can activate parkin implicating a more complex interconnection between neuroinflammation nedd8and parkinregulated phosphorylationdependent signaling in brain cells yet a mechanistic understanding of cellular processes triggered by neuroinflammation remain elusivethis proposal aims to investigate spatiotemporal phosphoproteome changes in response to neuroinflammatory stress elicited by proinflammatory cytokines and syn fibrils to achieve this i will combine spatialproteomics using subcellular fractionation and hybriddia in combination with the cuttingedge orbitrap astral mass spectrometer initial analyses of neuronal cell line models will be extended in a second step to hpsc derived neurons astrocytes microglia and cocultures thereof this enhances the translational relevance by mimicking neuroinflammation in the complex tissue architecture of the brain finally bioinformatically shortlisted neuroinflammationregulated proteins and phosphosites will be validated in cellbased models with this project i aspire to unravel the cellular mechanisms underlying neuroinflammation potentially unlocking new avenues for therapeutic strategies against neurodegenerative diseases
exploring the synergies between direct carboncapture nutrient recovery and nextgeneration purification technologies for costcompetitive and sustainable microalgal aviation fuel

microalgae can play a critical role in meeting eu targets to increase the share of sustainable aviation fuels safs in the aviation industry from 2 in 2025 to 64 by 2050 susalgaefuel will develop integrated approaches in a circular production model towards the first costcompetitive reduced by 49 from 123 to 63 kg hefa and efficient microalgae saf a direct capture of co2 emissions from biogas upgrading from anaerobic digestion ad and utilisation of waste liquid digestate as lowcost nutrient source to support algae growth b novel inline process analytical technology complemented with machine learning and selective uv irradiation to monitor and purify bacterial contamination in algae culture c cascading biorefinery that relies on energysaving autolysis and maximises solvent recycling to fractionate biomass into lipids for jet fuel protein serum for feed and celluloserich biomass residue for further fuel conversion at low energy solvent requirements d algaespecific thermocatalytic pathways for efficient conversion of algaelipids to hydroprocessed esters fatty acidssynthetic paraffinic kerosene hefaspk and residue to kerosene followed by a range of purification methods for fuel refinement to meet international aviation standards certificationprocess simulations techno economic lca will be performed to assess scalability from economic social environmental perspectives and to identify process improvements a dedicated commercialisation plan and policy recommendations will be produced to guide future technology transfer from lab to industry susalgaefuel will culminate in the building operation of a pilotscale algal facility on an ad operator site in ireland trl5 with the capacity to directly capture co2 from ad flue gas use waste digestate and produce 10 kg of algae lipids per year successful future scaling of the technology has the potential to deliver 20 of eus projected saf requirements of 5mt in 2030
modelbased estimation and control of agricultural infestations through abiotic changes

the goal of this project is to contribute to the ongoing precision agriculture revolution by developing modelbased control strategies for pest control the project will be carried out with a high interdisciplinary approach between control and system engineers and entomologists we firstly aim to develop models and methodologies that can guide in an optimal way the agronomical decisions both in terms of monitoring and of control actions that impact pest control to pursue this aim the first part of the project will be devoted to the development and validation of models able to capture both the spatial diffusion and the temporal evolution of insects in a plantation these models will be parametrized wrt environmental parameters temperature and humidity and control inputs eg pesticides the focus will be then shift on how to use these models for pest monitoring and in particular on the interplay between quality of the estimation and data collection in order to develop optimal data collection policies in the last part of the project we will use the developed results to develop modelbased optimal pest control policies although we aim to obtain a theoretical framework that is more general as possible two species of high agricultural interest drosophila suzukii and halyomorpha halys will be considered to validate the various steps of the theory this research project has a highly innovative approach and has the ambition at large to promote a new philosophy on pest management that goes beyond qualitative analysis and decision making proposing a quantitative modelbased approach to pest management the research objectives are highly original and focus on aspects of pest management that are highly relevant both from the applied and the research viewpoint we believe that the research and the tools that will be developed in this research project will have a major impact on both the scientific and the farmers community