Dragon09/odtu_chatbot huggingface dataset:
fareaudit fake news recommendations an auditing system of differential tracking and search engine results

the spread of disinformation is a serious problem that impacts social structure and threatens democracies worldwide citizens increasingly rely on disinformation available online either somewhat passively through social media feeds or actively by using search engines and specific websites in both scenarios algorithms filter and select displayed information according to the users past preferences there is a real risk that algorithms might reinforce the users beliefs and create disinformation bubbles by offering less divergent views or even directing them to lowcredibility content for these reasons serious efforts have been made to identify and remove fakenews websites and minimize the spread of disinformation on social media but we have not witnessed equivalent attempts to understand and curtail the role of search engines fareaudit addresses this imbalance and offers an innovative tool to audit search engines that can be broadly used it will help to 1 better understand how browsing history influences search engine results particularly the likelihood of being directed to disinformation 2 create a system that democracypromoting institutions and concerned citizens can use to identify new disinformation in near realtime and 3 breach information bubbles by simulating how search results would be different if users had a different online profile by relying on webcrawlers our tool is privacyprotecting and does not require any real user data moreover the proposed system anticipates the announced shift from cookietracking to fingerprinting and takes advantage of the expected small time overlap between both systems to learn from both and broaden its scope overall we expect this novel tool to have a meaningful social impact by increasing public awareness of the role of search engines on disinformation spread and by equipping organizations with a tool to detect and monitor disinformation especially in political contexts
measurement of gravitational effects on photonic quantum system

the interplay between the two main pillars of physics quantum mechanics qm and general relativity gr has never been understood or tested by scientists and this has become one of the most important interesting and challenging research areas over the past decades so far there is no experiment demonstrating how gravity affects unique quantum features eg superposition and entanglement this project is aimed to combine quantum interference and gr in a single tabletop experiment using machzehnder fiber interferometry single photons and entanglement states will be employed to investigate how gravity alters quantum correlations and superposition of massless particlesit would be a great scientific breakthrough to demonstrate gravitationalinduced effects on single photons and quantum states paving the way for quantum gravitational labscale experiments this project will push largescale highprecision single photon interferometry to a new level leading to the development of cuttingedge techniques from various disciplines quantum photonics precision interferometry frequency metrology etc this study is timely and highly relevant to the current eu research trends going in line with the prioritized research directions of horizon europe quantum technologies and time frequency servicesthis project will be implemented in the group of prof philip walther at the university of vienna the host group expertise in quantum control and their stateoftheart single photon facilities perfectly complements to the researcher dr yus background in interferometric gravitational wave detection and macroscopic qm phenomena this fellowship will enable the two parties to combine their skills and achieve the major scientific goals furthermore this fellowship will greatly improve dr yus leadership skills strongly diversify her knowledge establish new academic links and boost her track record that would have a significant impact on her academic career
sustainable urban net zero network for ukraine

sun4ukraine aims to bring together ukrainian cities with the eu 100 climate neutral and smart cities mission through capacity building technical expertise twinning multilevel governance and policy to support them in adopting climate neutrality targets and incorporating climate neutrality into reconstruction plans sun4ukraine will select and work closely with 10 ukrainian frontrunner cities who will receive technical support and participate in a capacity building programme to develop climate neutrality plans aiming for climate neutrality by 2050 a needs assessment will be undertaken to understand the specific needs of each of the frontrunners informing detailed design of support technical support will guide frontrunners through the process of setting targets and the gap to be filled identifying mitigation actions engaging citizens and establishing new governance designing climate neutrality plans and fundingfinancing their implementation connections with funders and financiers will also be made to facilitate implementation the capacity building programme will build the skills and capabilities of frontrunners and include at its core the peer learning exchanges and study visits of frontrunners to mission cities a ukrainian cities climate hub will be established to bring frontrunners and other ukrainian cities together to encourage mentoring ongoing partnerships and replication the lessons learned from technical support and the capacity building programme will be synthesised into guidance made available via the hub and mission platform policy dialogues and recommendations and good practices on multilevel governance will be developed to ensure ukrainian cities can become climate neutral by 2050 a targeted communication and dissemination strategy will complement and support implementation sun4ukraine will bring increased visibility to the cities mission and achieving its second objective of all european cities becoming climate neutral by 2050
towards materials at extremes from intense dynamic compression to expansion

the project aims at developing robust reliable and effective techniques for generation of extreme conditions positive tpa as well as negative mpa pressures in liquids will be produced with limited resources available in everyday research environmentthe project offers a unique integration of approaches and resources in high voltage engineering and plasma physics applications towards classical problems of compressible fluid mechanics it investigates by experiment computation and theory the major physical properties of imploding shock waves in liquids and offers approaches to enhance efficiency of the focal energy concentration the project develops a novel method for generation of imploding rarefaction waves a well controlled scenario that provides with exactly opposite range of extreme conditions namely negative pressures in liquids the approaches comprise a single generator facility that opens research on a broad spectrum of basictoapplied subjects promising a longterm investment towards studies of materials at extremesthe facility is applied on a selected subject of mechanical treatment of cellulose fibers aiming at enhancing the efficiency of fibres disintegration homogenization and fibrillation processes by applying both selectively and combined compression and tension pulses on a broad range of intensities from strong to extreme
uncovering commonalities and differences towards a novel framework for identifying endoflife trajectories of older people with serious chronic illness

older people who die from serious chronic disease typically experience long periods months or years of illness and complex fluctuations in their physical health and in their social psychological and existential wellbeing this project will conduct a mixedmethod interdisciplinary investigation of these endoflife trajectories it responds to the longstanding scientific challenge of identifying commonalities in endoflife trajectories across groups of people without masking important interindividual differences its central aim is to gain understanding of what is generalisable and what is individually specific in older peoples endoflife trajectories and in the circumstances that shape themthis project applies a novel methodological and analytical framework examining trajectories through two distinct scientific lenses a structured quantitative approach known from the biomedical sciences to capture fluctuations in a standardised way and an experiencefocused qualitative approach from the humanities to study the subjective stories and meanings behind changes in health in a convergent mixedmethods investigation this work combines 1 a large quantitative longitudinal study and 2 a serial narrative interview study both with older people 70 years or over with serious chronic illness who are nearing the end of life the results of these two methods will be integrated through triangulation and by systematically threading key findings from one method across to the otherthis work will lead to a fundamental rethinking of how we examine understand and categorise endoflife trajectories it will reveal the full extent of their complexity and indicate possibilities and limits of generalisation these novel insights will propel scientific advances towards achieving a good end of life in ageing societies they will also drive methodological innovation beyond my field balancing the perspective of the researcher and the researched
prostate focal therapy

the profth project aims at developing the robotics and ai technologies to enable focal therapies for prostate cancer pca using the robotic positioned developed during the ercpoc prost pca therapy is lagging about 10 years from eg kidney and breast therapies that has shifted from invasive surgery to percutaneous ablation of the tumour several trials are acquiring the clinical evidence to support the shift from radical prostatectomy to pca focal therapy considering the multifocal aspect of pca and the need to preserve the surrounding anatomical structures key to focal therapies is the ability to accurately and repeatably positioning the ablation device in the pca area and to achieve the minimal tissue removal that satisfies the safety margins around the tumor and leaves the other structures untouched the problem of accurately positioning a biopsy needle in the pca area has been solved by the prost project thus we want to build on this capability to set the basis of pca focal therapy to achieve this goal profth will address three main objectives 1 definition of the joint requirements between clinical needs capabilities of the current ablation devices and positioning accuracy of prost 2 development of the digital twin of the pelvic area to integrate the medical information of the patient and 3 develop a planning algorithm that will compute the position of the ablation devices in the patient pca we will test the developed algorithms with laboratory and exvivo experiments using the ablation systems available at the university hospital of verona
colour4crafts colour for combining reengineering applying futuring transforming stretching

colour4crafts proposal combines a multidisciplinary team of experts from research institutes and rd companies to carry out studies of biobased textile colouration in traditional historic perspective and in combination with cuttingedge technologies of colourants biosynthesis and waterless applications techniques the researchers are top experts in archaeology and history textiles and colouration biotechnology and chemistry art craft and education research combines methodologies of history artefact research and cultural studies art and craft research natural sciences and futures studies this creates a manifold basis to understand colouration practices in history and craft context profoundly and create innovative stateoftheart solutions for the futures biobased practices multidisciplinary methodologies enable the development of new research methodological openings education and communication have important roles as they create and enable interventions for traditions transformation into futures green industries this research proposal supports and fosters european cultural heritage and the european cultural and creative industries and it initiates new high quality biocolourant and colouration businesses in europe research aims to foster craft skills in textile colouration and transform the traditional processes into sustainable cuttingedge processes which support futures green deal objectives through research provide new profound knowledge of traditional craft colouration practices in europe and especially in the north eastern baltic area and by combining this knowledge with novel technologies create innovative colourants and colouration practices this helps increasing sustainability in craft scale colouration and more broadly in industrial scale textile production through futures research methodologies project provides futures visions and the path to the most desirable colouration and textile production practices in europe
innovative singlecell rnaseq kit to support large democratization of insglecell analysis

this project will develop and perform the industrial scaleup of a gamechanging scrnaseq tool named deepincell this solution in a kit format plus a cloud software analysis suite will use the proprietary hydrogelbased revgel technology of asteria kit as a basis for a new generation of kit that ambitions to dramatically simplify access to singlecell studies with a shorter time to result far easier robust and authentic transcriptomepreserving technology multiplied by reducing cost per sample this new generation of kit shall bring a similar revolution to the singlecell market as did the qiagen rna extraction kit in its time to the genomic market while providing performances at par with that of the market gold standard and monopolistic costive instrumentbased singlecell technology 10xgenomics this next generation of singlecell rnaseq kit is expected to first launch in late 2024 with first applications to the international singlecell research market and to generate sales exceeding 50m by 2029 it is foreseen to become the quintessencial singlecell rnaseq kit that will open access to singlecell studies to a much broader research community
demography and social structure of polynesian outliers genomic investigations of over 100 individuals buried in namu taumako island

oceanians are descendants of two main migration waves the early migration of modern humans outofafrica more than 50000 years ago ya which ended in the solomon islands near oceania and the austronesian expansion that started around 5000 ya in taiwan and peopled the remaining unexplored territories of oceania remote oceania up to polynesia from 3000 ya subsequent migrations within the region created a complex genetic landscape near oceanian populations moved into remote oceania at least 2500 ya afterwards polynesianspeaking groups expanded westward outside the polynesian triangle to other oceanian islands giving rise to the socalled polynesian outlier communities this complex population history created a highly differentiated sociocultural background among oceanians whose interactions remain poorly understood we will leverage genetic data for 114 ancient individuals from the ancient polynesian outlier site of namu a burial in the taumako island occupied from the 13th to the 18th centuries ad which represents to our knowledge the largest ancient dna dataset ever studied from a single site we will use cuttingedge paleogenomic methods to study the settlement processes and the demographic history of taumako and the social organization and socioeconomic stratification of the namu site according to genetic ancestry sex kin relations and age the ultimate objective is to understand the structure of oceanian societies and its relation with their migratory history to achieve the projects goals i will integrate in the archaeo and palaeogenetics group at the university of tübingen under the supervision of prof dr cosimo posth who is a worldwide known expert in paleogenomics this innovative and multidisciplinary project is a unique opportunity for me to learn the full range of paleogenomic techniques from a leading group in the field and to establish myself as an interdisciplinary leader in this expanding research area
centre for excellence in diagnostic and advanced therapeutics based on extracellular vesicles

in recent years extracellular vesicles evs have emerged within the scientific community for both biomarkers and therapeutic applications however the translation of the research findings represents a major challenge for biomedical research and healthcare international cooperation is paramount to moving research findings to clinical applications and defining standard operating procedures evca addresses this unmet need through a scientific strategy to reinforce research and innovation ri excellence in the study of ev applications in diagnosis therapeutics and etiology of chronic diseases the chronic diseases research center of the nova medical school unl aims to be at the forefront of international scientific excellence in applying evs to diagnostic and therapeutic clinical priority challenges in chronic diseasestowards this goal unl is twinning with the cic biogune spain and institut curie france international references in evs evca will leverage on the partners outstanding multidisciplinary knowledge experience research and training best practices as well as collaborative networks to enhance the research capacity and innovation potential of unl evca is an integrated network of interactions exchange and training of researchers satellite meetings winter retreats virtual think tanks links to industry etc articulated with the individual and joint scientific agendas of the partners to power the research capacity of unl and of its ri ecosystems evca expects to increase by 25 in multiple indicators by 2026 including the number of citations hindex of unl researchers percentage of publications in top impact journals number of international collaborations including with industry by stimulating novel and longlasting interactions between the partners evca will unlock the research potential within and outside unl with an overall increase in the portuguese and european rd research competitiveness
development of glioblastoma and bloodtumour barrier models for investigating the combination therapy of anticancer agents and efflux pump inhibitors

glioblastoma gbm remains the most common malignant primary brain tumour with a median survival 2 years one of the reasons for the failure of gbm therapy involves limited drug access to the tumour site due to the presence of the bloodbrain barrier bbbbloodtumour barrier btb although these barriers differ they share some common features such as tight junction tj and efflux proteins of the atpbinding abc cassette superfamily that regulate drug access to the brain parenchyma similarly efflux proteins have been identified in gbm that form an additional barrier in the proposed research fivedimensional 5d models of gbmbtb will take into account all characteristics essential to approach more realistic in vivo conditions mainly the integration of glioblastoma stem cell gsc derived pericytes into btb and the incorporation of varying degrees of tumour cell differentiation from gcs to well differentiated cells showing a different degree of intrinsic chemoresistance additionally microfluidic models reproducing blood flow will add a temporal and dynamic dimension 5d models once the models are established and compared with static ones the effect of anticancer therapy and efflux protein inhibitors epis will be verified in terms of tj and abc protein expression using qrtpcr and confocal microscopy the identified combination therapy of anticancer agents and epis will lead to validation in patientderived gmbbtb models with different molecular profiles and degrees of resistance with the goal of personalised medicine by working on this project the researcher will gain valuable experience that is needed to address the challenges associated with the treatment of therapyresistant tumours in general this project may provide a more realistic view of the potential effect of combination therapy under in vivo conditions this could ultimately expand the treatment options for cancer patients and increase their chances of survival
the envola storage heat pump enables the worlds first highly energyefficient heating cooling and ventilation system significantly reducing energy consumption and greenhouse gas emissions in europe

the heating and cooling of buildings is one main energy consumer in europe especially residential heating is the main emitter of greenhouse gases and other air pollutants and air conditioning systems heavily contribute to urban overheating overall currently the heating and cooling of buildings fosters climate change and causes negative effects on public health to face this and to make european buildings more efficient regarding heating and cooling envola found the technical solution to bring air conditioning and air heat pumps to the next level of high efficiency with our venticer hvac system the energy consumption can be significantly reduced by 50 for cooling and 30 for heating compared to the best products available the new envola heat pump technology integrates the required ventilation system in the same heat pump process therefore the investment cost for this new highly efficiency technology is significantly lower than state of the art systems in daily application
examining how past demography affects genetic load using ancient dna

dna can survive millennia postmortem spanning ecological and evolutionary transitions and providing a unique window into the processes underlying biodiversity as such sequencing ancient dna from temporally spaced samples can allow the testing of hypotheses related to evolutionary responses to ecological change and novel selection pressures through direct quantification of ecological and genetic parameters collected before during and after genetic changes in selection pressures here i propose to do just this taking advantage of a natural experiment of an emblematic study system in evolutionary biology parallel independent adaptation to freshwater by marineadapted threespine sticklebacks through the rise in frequency of freshwaterassociated alleles utilising palaeogenomics to sample genomes along this evolutionary continuum and the project will address a key and longstanding question is there a mutational cost to natural selection this is a timely question as ongoing rapid global climatic change is a major source of novel selection pressures therefore understanding the dynamics of natural selection will provide key insights into potential outcomes for biodiversity the methods developed in this project will not only benefit the growing field of paleogenomics but also other fields where data is collected in a temporal manner such as experimental evolution and epidemiology ultimately achievement of these goals requires the formation of a dedicated closely knit team focusing on both the methodological challenges as well as their bigger picture application to highrisk highgain ventures with erc funding this can become a reality enabling the interface of palaeogenomics and evolutionary biology to be pushed to the new limits of the modern sequencing era