Dragon09/odtu_chatbot huggingface dataset:
unravelling the role of neuronal antibodies and innate immunity partnership in human autoimmune encephalitis

autoimmune encephalitides ae are severe brain disorders mediated by antibodies against neuronal proteins such as the nmethyldaspartate receptor nmdar the antibody effects are reversible explaining recovery after antibodydepleting therapies however it is unknown why many patients have incomplete recovery and persistent deficits in these cases additional immune mechanisms might be at playthe objective of immubrain is to define how the adaptive immune response autoantibodies crosstalks with innate immunemechanisms resulting in neuronal dysfunction or death by using nmdar encephalitis as a disease model cuttingedge antibody engineering will define the unexplored contribution of antibody glycosylation which modulates innate functions to neuropathologyimmubrain combines human studies with experimental models human studies will extensively profile patients nmdar antibodies using a novel antibodyomics platform characterize the compartmentalized antibody responses between brain and periphery using bcell receptor repertoire analyses define the distribution of brain innate infiltrates and quantify neuronal death using advanced microscopy in vitro models will determine the effects of patients and glycanmodified antibodies on neurons using confocal microscopy and electrophysiology explore the neuronmicroglia interactions during trogocytosis using superresolution and live cell imaging finally a new mouse model of nmdar encephalitis will serve to define the dynamics of antibody and innate responses over time and at different disease stages and explore the therapeutic role of in vivo antibody glycan modifications in reversing the observed behavioural and molecular alterationsthese findings will revolutionize the current understanding of innate immune mechanisms in ae and other inflammatory brain disorders and will provide novel antibodymodulating therapies eg glycan modifications that will ultimately improve patients outcomes
innovative concepts and technologies for ecologically sustainable nutrient management in agriculture aiming to prevent mitigate and eliminate pollution in soils water and air

econutri is a consortium of scientific experts and researchers from different disciplines private companies farmers associations and stakeholders econutri is partnering with six chinese institutions four from public research and two from industry to complement activities and to strengthen the scientific collaboration between europe and china the project will scientifically support the eus green deal in its target to reduce fertiliser use by least 20 by 2030 thereby reducing by 50 losses of nutrients associated with negative environmental impacts more specifically econutri will address water pollution caused by no3 and p leaching and runoff from cultivated soils manureslurry and plant residues as well as greenhouse gas n2o co2 ch4 and nh3 emissions from cultivated soils barns and organic biomass during storage composting and land application econutri will optimise validate and demonstrate 24 innovative technologies that currently have a trl of 46 and will increase their trl to 78 these technologies are integrated parts of a holistic concept based on recycling of nutrients and organic material novel machinery and fertilisers novel decision support systems dss and novel nutrient management plans incorporating naturebased solutions to reduce nutrient losses and to increase nutrient use efficiency the expected results include hyperspectral analysis algorithms advanced online dss platforms to develop smart nutrient management plans for organic and conventional crops protocols for circular cropping systems in open field and greenhouses advanced emission monitoring feedback systems novel manure spreaders variable rate technologies for precision fertilisation smart fertilisers and biostimulants increasing n use efficiency econutri will establish eight demonstration sites and deploy a comprehensive range of dissemination communication and exploitation activities to maximise the impact of the expected results and technologies
mitochondrial nanoscale morphofunctional remodeling in mechanometabolism sense force change shape modulate energy

mitochondria are doublemembrane organelles that sustain the bioenergetic metabolism of cells by producing atp at the level of the cristae convoluted folds of the inner membrane atp production efficiency and mitochondrial morphology including cristae architecture are tightly linked consequently by being coupled to mitochondrial function the reshaping of mitochondria across spatial scales regulates the cellular bioenergetic and metabolic states mechanical stimuli have recently been shown to modulate cellular metabolism thus impacting physiological eg cell migration proliferation death and pathological eg cancer progression processes mechanical forces are able to reshape the global morphology of mitochondria however cristae remodelling upon mechanical stimuli has not yet been unravelled and it remains unknown whether mitochondria are the key regulators of bioenergetic mechanometabolism in mitomechamet project i aim to unveil how forceinduced changes in mitochondrial cristae architecture aim1 modulate cellular bioenergetic metabolism aim2 via nanoscale reorganization of proteins regulating mitochondrial shape aim3 these ambitious objectives will be achieved by bringing together my experience and skills on mitochondria imaging the expertise of the host laboratory g giannone lab cnrs bordeaux on mechanobiology and superresolution and the knowhow of collaborators regarding mitochondrial metabolism biodynamit lab cnrs bordeaux mitomechamet results will impact several fields ranging from biophysics and biomechanics to cellular biology especially cancer biology where mechanical cues in the tumor microenvironment critically regulate mitochondria dynamics and cancer progression altogether the mitomechamet project represents a uniquely tailored opportunity for me to master the necessary skills experience and independence to pursue my longterm aspiration of leading an independent lab investigating mitochondrial biomechanics
proteomic analysis of cell communication in tumors

cancer is an enormous biomedical challenge in part due to the complexity of cancer cell dynamics the combination of intrinsic genetic alterations and cues from the tumour microenvironment impact the cancer phenotype and create heterogeneous tumours that evolve in space and time cancer cells develop distinct phenotypes in diverse tumour regions and different metastatic locations in addition cancer progression metastatic dissemination and development of therapeutic resistance affect cellular interactions over time therefore understanding tumour dynamics is critical for the development of novel therapeutic approachesalthough tumour heterogeneity has been thoroughly investigated at the genomic and transcriptomic levels limited studies have investigated heterogeneity at the proteomic level changes in protein expression are central determinants of cancer phenotypes developing a detailed understanding of proteome dynamics would be an enormous scientific advancement in the cancer field however technological challenges and specifically the challenge of analysing single cells and small groups of cells have delayed progress along these lines here i propose to combine my cuttingedge clinical proteomic expertise and extensive experience in cancer biology to study the spatial and temporal heterogeneity of cancer at the proteomic levelwe will push the boundaries of the technology towards assaying thousands of proteins from single cells and small groups of cells from invivo samples we will combine microfluidic probe technology to map primary tumors and metastases at high spatial resolution and study mouse models of melanoma and breast cancer to follow temporal changes in metastatic growth and treatment response this breakthrough in proteomic analysis of cancer dynamics will provide the basis for targeting treatmentresistant metastatic cell populations towards advanced personalized treatment
optimal particle identification of single site events with underground mkids detectors

the observation of neutrinoless doublebeta decay 0 would revolutionise our understanding of neutrinos by affirming their majorana nature and shedding light on their absolute mass scale and hierarchy detecting its monochromatic peak at mev levels with halflives over 1026 years is a significant challenge scientists are striving to push the scale of experimental exposures to tons of material per years it is only in a backgroundfree experiment that sensitivity scales linearly with exposure maximising the benefits of increased detector mass the forefront of this search lies with tonscale arrays of bolometers at mk temperatures such as cuore which investigates 0 in 130te using teo2 crystals known for their exceptional energy resolution but plagued by background event identification challenges with its 34 isotopic abundance 130te emerges as the leading 0 candidate bypassing the need for the nowchallenged enrichment process opossum will revolutionise event detection by outfitting 12 cuorecrystals with six quantum limited sensors microwave kinetic inductance detectors and a thermistor this innovative approach will enable discrimination of events by classifying them as single site or multi site events through pulseshape analysis opossum is set to tag 0 signals with 3 distinction from any background this method has the potential to lower cuores background from 102 to below 104 countskevkgyear the success of opossum will facilitate rapid deployment within the existing setup without extensive rd or major financial outlay opossum1ton is poised to become the first bolometric tonscale backgroundfree experiment that can aim at surpassing the inverted hierarchy scenario ie 10 mev majorana massmy vast experimental knowledge in lowtemperature detectors is crucial for opossums mission to push the boundaries of particle physics as per the eu astroparticle committee recommendation for the neutrino physics programme
triop an intraoperative probe to assess tumor margins and remove tumor residues in real time

cancer is the 2nd most common cause of death worldwide oncological surgery is the most efficient singletreatment and is the most used as primary treatment however the local cancer recurrence rate after the first surgery is still high in every organ local cancer recurrence is mainly caused by tumor growth from remaining tumor residues they have a major impact on survival quality of life and require reinterventions andor adjuvant treatments therefore the main issue today in oncological surgery today is to ensure the resection quality and remove the whole tumor while minimizing healthy tissues removal to achieve it surgeons need real time information on tumor residues locationbeams is a medtech company incorporated on the 17th of may 2021 to answer this unmet medical need beams develops triop tumor resection intraoperative probe technology a miniaturized intraoperative probe which measures the accumulation of existing radiotracers in tumor tissues after their injection in the organism and then informs surgeons in real time about the precise tumor localization to help removing the tumor while preserving surrounding healthy tissues the targeted impact is to prevent local cancer recurrence and to preserve patients quality of lifethe first beams product based on triop technology will be a multipurpose intelligent surgical aspirator the detection system will be built around an aspiration tool to remove tumor cells blood and other secretions that could alter the detection simultaneously with examining the operative cavity
network of national contact points for cluster 6 food bioeconomy natural resources agriculture and environment

care4bio serves the needs for transnational cooperation between ncps for cluster 6 as well as for crosscluster cooperation within pillar 2 but also with other programme parts such as widening participation we comprise a wellbalanced network of 26 partners including partners from the eu13 and associated countries combing all levels of relevant experience and expertise many of us fulfil multiple roles for instance also working in ncpwideranet ncp academy or een different clusters and pillars or appointed as programme coordinatorswe are well setup to deliver on our objectives namely to 1 harmonise ncp services and increase their quality via transnational cooperation 2 lower entry barriers for applicants especially in less active member states and raise the quality of submitted proposals 3 inform the european rd community about crosscutting synergies throughout horizon europeto achieve this we will cooperate with other ncp networks such as the ones mentioned above to share knowledge and best practices maximise efforts on informing ncps applicants and stakeholders thereby raising the quality of proposals breaking down silos and encouraging transcluster collaboration we will cooperate with the european commission to assist in delivering upon political objectives such as the eu green deal guiding applicants on policies and providing feedback from our work as ncps we also offer concrete services for applicants eg by organising yearly brokerage events to aid applicants in forming their own cooperation networks and by supporting other matchmaking effortsour services will include training learning resources best practice manuals policy briefings and more while our services will be available to whoever needs them our focus is on ncps and applicants from widening countries ultimately our goal is to raise the general standard of support for potential applicants of horizon europe contributing to increasing the quality
spain on stage dance and the imagination of national identity

this project aims to propose new narratives of spanish dance history analysing the components processes and contexts involved in the configuration of the dancing body through its negotiations with national identity at the turn of the 20th century it will recuperate study and reconstruct a corpus of choreographies and dances conserved in footage and film fragments between 1894 and 1936 the period between the crisis of the colonial system and the military coup that caused the civil war and the following four decades of dictatorship the study will articulate new theoretical tools to rethink the place of spanish dance between the colonising and the colonized understanding the body as a living archive through intersectional and transcultural perspectives a research team from csic will apply a groundbreaking interdisciplinary methodology based on three main areas archivebased research practiceinresearch and movement analysis and dance motion capture and 3d animation thus it will provide a theoretical and practical understanding of the evolution of the languages codes and gestures in order to integrate that reading into a revised history of spanish dance the versatile results will include an openaccess dance motion capture database and the basis for a virtual spanish dance museum through an immersive virtual reality platform serving future research projects dance companies educational institutions and the general public finally the results will contribute to enjoying these recovered treasures of european intangible heritage and preserving them for the knowledge of future generations
reducing carbon footprint for generative ai

executive summarygenerative ai systems such as chatgpt recently passed the turing test forever transforming humanmachine interaction these systems provide giant productivity leaps across many sectors however their energy requirements increase ninefold annually and their abundance grows at exponential rate the resulting carbon footprint becomes significant it giants such as google nvidia microsoft and amazon as well as many midsized companies have committed to reduce their carbon footprint the eu is strengthening regulation for emission reductions but the new generative ai trend jeopardizes emission reduction commitmentsmost power consumption of generative ai is spent on matrix multiplication our novel solutions reduce energy consumption and carbon footprint by replacing current matrix multiplication algorithms with more efficient ones these can be implemented on existing hardware and software stacks potential energy saving predicted at about 4050 while maintaining performance and accuracythe novel developments of prof oded schwartz and his strong team are based on years of research and protected by patents the funds are requested to pursue business opportunity
fabrication of selfpowered 2d mos2 fieldeffect synaptic transistors actuated by triboelectric nanogenerators for neuromorphic application

the development of neuromorphic devices and sensory networks has led to the creation of new systems similar to human brains anartificial synapse can be used to perform various functions such as longterm potentiation depression and spiketimingdependentplasticity various types of synaptic electronics can be used to develop sensory neurons some of these include threeterminal devicesand memristors with neuromorphic configurations however a particular device ideal for neuromorphic applications is a fieldeffecttransistors based on the twodimensional layered semiconductor to reduce the energy consumption of artificial sensory neurons aselfpowered neuromorphic system can be developed that can operate on mechanical energy this strategy can be useful indeveloping systems that are energyefficientthis project aims to develop a functional and biological selfpowered artificial synapse sensory system similar to the humansomatosensory system this will allow engineers to create selfpowered electronic sensors actuators and communicators capable ofhandling biological intelligence this project fasttribonic involves the development of highperformance fieldeffect synaptictransistors with 2d mos2 layered semiconductors and the construction of powerful triboelectric nanogenerators tengs for the effectiveconversion of mechanical energy into electricity also to develop an indigenous neuroelectric interface artificial electronic skin by integrating synaptictransistors and teng during nonacademic placement by coupling teng and fieldeffect transistors a new fieldof tribotronics has been established for devices such as memory chips and tactile sensors these technologies are expected to play avital role in developing modern highperformance energyefficient selfpowered wearable electronic devices
collaborative edgecloud continuum and embedded ai for a visionary industry of the future

clever proposes a series of innovations in the area of hardware accelerators design stack and middleware software that revolutionize the ability of edge computing platforms to operate federatedly leveraging sparse resources that are coordinated to create a powerful swarm of resources clever technologies will support the deep edge computing paradigm moving computing services closer to the end user or the source of the data to reduce power consumption reduce capacity requirements and latency for mission critical applications furthermore clever will overcome traditional limitations of edge computing in terms of limited resource availability by providing an effective framework for seamless use of federated resources in the edgecloud continuumclever will demonstrate processing solutions for ai at the edge through four use cases 1 digital twin for infactory optimization 2 smart agriculture for high yield ecofarms 3 fully automated material deployment and 4 augmented reality for shopping sitesthrough the achievement of its goals the clever project will help to position europe at the forefront of the intelligent edge computing field enabling growth across many sectors manufacturing agriculture smart environments augmented reality and others by lowering the barriers for utilising edge computing for artificial intelligence applications clever will open the door for european industries and smes to leverage state of the art technologies driving their development and growth as leaders in their sectors
a smart and adaptive framework for enhancing trust in 6g networks

the 6g vision for an open distributed and usercentric evolution of the current sba core network creates many security challenges and risks the disaggregated heterogeneous cloud continuum ie distributed cloud system with many stakeholders located in different regions while private public or hybrid clouds are considered for the formation of the continuum in conjunction with softwarization and itbased infrastructure operations set the stage for risks and challenges to trustworthiness in the 6g eraon top of the open and distributed 6g core over the edgecloud continuum safe6g proposes a holistic research approach aimed to design develop and validate a 6gready native trustworthiness framework by enabling usercentric safety security privacy resilience reliability functions by utilizing xaiml techniques to cognitively coordinate and balance these functions in order to optimize the level of trust lot which realises the trust requirements and data governance policy that each usertenanthumanrole specifies a feature that is considered an essential kvi for usercentric 6g the proposed safe6g framework covers the whole trustworthiness 6g lifecycle by applying trustworthiness analysis realisation and postevaluation during the whole usercentric service provision from onboarding and deployment to operation and decomposition verification and validation of the proposed safe6g framework will be performed at the stream c sns 6gsandbox athens platform using two metaversebased pilots the immersiveapplications will be tested considering different 6g system setups different service flavors and deployments under various threats and attacks
energy level engineering of basal plane of metal dichalcogenides mose2 and wse2 by doping of transitionmetals for the fabrication of energy storage devices

in power a novel asymmetric supercapacitor sc will be fabricated using twodimensional 2d transition metal tm doped dichalcogenides with the aim of developing the next generation of high energy and power density scs as energy storage devices for the first time tm fe co ni mn and zn doped 2d mose2 and wse2 will be used to fabricate the asymmetric sc and combined with a battery to form a hybrid this is a timely proposal as the energyhungry world demands more energy and this growing demand for electrical power requires sustainable energy conversion and storage systems this is aligned directly with the eus energy storage and development roadmap up to 2030 the tm doped mose2 and wse2 will be synthesised using low temperature hydrothermal approaches and then mixed with binders and used to form the negative electrode a commercial activated carbon electrode will be used as the positive electrode to give the asymmetric sc the modified electrodes will be characterised using high resolution surface analytical techniques and electrochemical methods the performance of the fabricated scs will then be assessed and the potential applications of the optimised sc considering both the tms and dichalcogenides will be explored by working on power the fellow will have the opportunity to focus on a multidisciplinary project encompassing physical chemistry physics materials electrochemistry and energy with global impact in the energy sector through a tailored career development plan with a 3month secondment at tu delft the fellow will be able to establish new research collaborations within europe and reach her goal of becoming an independent researcher with communication targeted on various groups and potential end users the fellow will develop the skills required to communicate with nonexperts including the public community groups and charities enriching her academic experience in the nonacademic sector