Dragon09/odtu_chatbot huggingface dataset:
arctic crosscopernicus forecast products for sea ice and icebergs

sea ice and icebergs are a major security risk for navigation and fisheries in arctic waters both will remain a significant threat even in a warmer arctic where traffic is expected to increase sea ice services are needed more and more to support less experienced captains with automated high quality forecasts and new information about icebergs that are not available todayto monitor and forecast sea ice types and icebergs ahead of time adequate forecasts of sea ice ocean wind and wave conditions for the whole arctic are crucial the copernicus marine and climate change services provide such information products however their uncertainties are not provided in a consistent and userfriendly manner reliable uncertainty estimates can however be based on forecast ensembles across the two copernicus services acciberg will improve the quality of sea ice and ocean products and their uncertainty estimates in both copernicus services it will also extend the coverage of the satellite detection of icebergs and develop a completely new iceberg forecast service acciberg will build upon state of the art sea ice and ocean models remote sensing algorithms data assimilation and cloud computing to offer probabilistic sea ice and iceberg forecasts based on copernicus data consistently national or commercial sea ice services are limited to smaller regions and will benefit from the increased accuracy and consistency across the copernicus products the new forecasts will be demonstrated in acciberg by european ice services and ships of opportunity the new iceberg forecasts will be automated and validated and benefit a wide range of user groups navigating in the arctic from fisheries to cruise tourism including marine surveillance under the copernicus security service we will provide prototype products ready to be implemented in the copernicus services and accessible from a single entry point its inherent cloud computing solution
hyperbolic surfaces and large random maps

the main purpose of this proposal is to explore random planar metrics two canonical models of random continuum surfaces have been introduced in the past decade namely the brownian sphere obtained as the scaling limit of uniform random planar triangulations and the liouville quantum gravity metric obtained formally from the exponential of the gaussian free field on the sphere our objective is to broaden our understanding of random planar metrics to the case of metrics with holes or hubs and to the causal when a time dimension is singled out paradigm we also plan on studying random maps in high genus and to connect to models of 2dimensional hyperbolic geometry such as the brookmakover model random pants decompositions or weilpetersson random surfaceswe believe that the tools developed in the context of random planar maps such as the systematic use of the spatial markov property the utilization of random trees to decompose and explore the surfaces or the fine study of geodesic coalescence can be successfully applied to the aforementioned models we expect spectacular results and we hope to reinforce the connections between those very active fields of mathematics this proposal should give rise to exceptionally fruitful interactions between specialists of different domains such as probability theory twodimensional hyperbolic geometry and theoretical physics as well as mathematicians coming from other areas in particular from combinatoricsto ensure the best chances of success for the proposed research we will rely on the unique environment of university parissaclay and neighboring institutions
capturing tumoral drug metabolism by cells in the tissue environment using spatial pharmacometabolomics

small molecule anticancersmall molecule anticancer therapies generally have a well understood mechanism of action still they are frequently plagued by poor efficacy and high rates of treatment resistance especially in the context of pancreatic cancer one promising newly recognised route of therapy resistance is intratumoral drug inactivation through members of the tumour microenvironment tme such as the tumourassociated microbiome with the cite project i aim to develop novel analytical technologies that enable us to study drug metabolism by the tme in situ and in isolation from systemic drug metabolism and provide a novel platform for selectively studying the contribution of the tme to drug resistance mechanisms i will deploy a spatial pharmacometabolomics approach using laser desorption rapid evaporative ionisation mass spectrometry ldreims first a novel and sensitive source setup including laser optics and high efficiency aerosol transfer will be developed followed by instrumental setups for imaging applications at subcellular resolution high throughput acquisition of cell lines and thick tissue section imaging subsequently a spectral database of abundant tumour endothelial cells fibroblasts etc and rare cell types immune cells microbiome in the tme will be created to enable celltype specific assignment of drug delivery and drug metabolism in mass spectrometry imaging datasets and validated using imaging mass cytometryi will develop a organotypic culture 3dotc model of pancreatic cancer to study isolated intratumoral drug metabolism in a controlled environment while still using relevant clinical material we will use pancreatic cancer from a genetically engineered mouse as model system to develop our novel analytical technologies and to assess intratumoral metabolism of small molecule cytotoxics and targeted chemotherapies used to treat pancreatic cancer lastly these findings will be translated to tissues of human origin
innovative environmental multisensing for waterbody quality monitoring and remediation assessment

environmental water pollution is a growing global issue leading to increasing regulations and concurrent increased demand for improved water quality monitoring solutions to meet the european green deal objectives real time in situ devices offers the promise of more rapid and efficient monitoring and numerous such solutions are available from a wide number of primarily noneu suppliers however existing in situ solutions detect very limited parameters and are restrained by high costs low reliability and high energy usage to better meet end user needs and improve environmental water quality monitoring novel sensing technology is required to this end ibaia will develop four innovative optimally functionalised sensor modules based on complementary photonics and electrochemical ec technologies midir will be used to detect organic chemicals visnir for microplastics and salinity optode technology for physicochemical parameters and ec technology for nutrient salts and heavy metals leveraging consortium expertise in cutting edge material science microfluidics data processing and integrationpackaging technology these four sensors will be integrated and packaged into a single advanced multisensing system and validated by end users in real in situ conditions the ibaia system will more accurately monitor a wider range of parameters than existing solutions whilst simultaneously being more cost effective more reliable more environmentally friendly to manufacture and more user friendly to use these dramatic improvements will manifest in an extremely competitive product that acts as a onesizefitsall solution for many end users with a highly eucentric supply chain that will supplant a wide number of inferior noneu alternative solutions
european training program to understand diagnose and treat autosomal dominant retinal diseases

progret will create a multidisciplinary and intersectoral european training network focusing on the mechanisms diagnosis and therapy of dominantly inherited retinal diseases ird ird represent a major cause of blindness affecting 350000 people in europe ird have long been considered incurable however major advances have led to groundbreaking new treatments today the most important challenges in the ird field relate to an unsolved genetic diagnosis unknown disease mechanisms and gene therapy development for autosomal dominant ird adird representing 2540 of all ird cases we have demonstrated an emerging role for splicing factors structural variants and noncoding defects in patients with adird and developed novel disease models and gene therapies for adird progret aims to dissect adird mechanisms using retinal stem cell and aquatic animal models to advance adird diagnostics using a singlemolecule multiomics framework and to develop innovative treatments based on rna therapy and crisprgenome editing these challenges will be tackled by integrating unique expertise and cuttingedge technology within progret including multiomics bioinformatics functional genomics rna biology gene regulation stem cell technology retinal organoids animal models genome editing and gene therapy progret will give doctoral candidates dcs unparalleled training opportunities in outstanding academic and industrial settings through trainingbyresearch via individual research projects secondments and networkwide training sessions all individual training and research activities will provide each dc with the necessary skills in academic and industrial research progret will make a career in both sectors attractive and improve their career prospects finally our multidisciplinary network offers a unique opportunity to accelerate the understanding diagnostics and therapeutics for adird in europe and to translate research findings to healthcare and society
paneuropean food systems science network

the vision of fossnet is a strengthened and deepened academic network to support a new knowledge and innovation governance structure for europes food system a new structure is needed as the current knowledge and innovation system in the european research area is insufficient to address the emerging challenges of nourishing the european food system in a healthy sustainable and fair way the aim of fossnet is twofold on one hand to establish a permanent paneuropean network for food system science and on the other hand to advance inter and transdisciplinary food system science and education this will contribute directly to the farm to fork objectives and food2030 priorities developing the network and advancing food systems science and education will be underpinned by an inclusive approach to ensure engagement of all relevant disciplines researchers and nonacademic actors in advancing food system science in order to reach the vision and aim fossnet will 1 develop a conceptual framework and a process for developing food system transformation pathways to create a common language and understanding among food system thinkers 2 establish mobilise and consolidate an inclusive inter and transdisciplinary paneuropean academic network for food systems science to bring european food systems scientists and the science institutions together 3 enhance inclusivity of the knowledge and innovation system for a sustainability transformation of eu food systems by addressing sensitivities to power relations and inequities that pervade food systems and contested transformation processes 4 coproduce research for sustainable food system transformation to remove existing barriers to interdisciplinarity in food system science 5 build food systems capability through an academy and curricula to ensure the impact of future food system thinkers and 6 create scientific economic and societal impact by ensuring sustainability of the network
the role of interpersonal neural synchrony during verbal conversations correlation causation and personalization

verbal conversations are a hallmark of human social interaction and are supported by various sociocognitive processes promoting specific conversation patterns for instance more engaging conversations are marked by how often and quickly participants switch turns speaking turntaking similarly an engaging conversation is also marked by the interlocutors converging towards a common phonetic space phonetic convergence one of the neural mechanisms supporting these conversation patterns is proposed to be interpersonal neural synchrony ins the coupling of brain oscillations between two interlocutors however only a few studies truly tested the role of ins during freeflowing conversations these studies have some limitations as they were either conducted in a nonecologically valid context or the evidence was purely correlational in addition important interdyadic differences were neglected the present project syncon aims to overcome these limitations by combining eeg hyperscanning with multiperson brain stimulation tacs and personalized neuroscience i will first measure the correlation between ins and mutually engaged conversations marked by enhanced turntaking and phonetic convergence the measurement will yield a dyadspecific ins profile considering properties such as frequency phase and topography utilizing a longitudinal design these profiles will allow me in a second experiment to exogenously induce ins between interlocutors and in turn promote mutually engaged conversations ie increased turntaking and phonetic convergence understanding the causal role of ins in conversations will have groundbreaking applications for facilitating interpersonal communication across therapeutical and educational contexts accordingly this project will address critical gaps in our understanding of the neural underpinnings of human communication and its potential use in applied contexts
timing cell cycles in multicellular development

animal development depends on precisely timed cell divisions which ensure the formation of tissues and organs with specific architectures and functions as cells differentiate and mature they need to modify the expression of cellcycle regulators in order to achieve tissuespecific division patterns it is largely unknown how cells coordinate cellcycle gene expression changes with developmental timing and how cell cycles can be altered to give rise to different tissue architectures and organ sizesdevcycle will address these questions by studying intestinal cell cycles in nematodes i have recently pioneered tools to measure mrna expression changes and chromatin modifications in purified intestinal cells from c elegans which we will use to uncover how the expression of cellcycle genes is changing during development and to identify novel regulators that control stagespecific gene expression moreover i will implement a novel microfluidics platform for longterm imaging of larval development to identify the mechanisms that allow temporal coupling of cell cycle and development this system will allow us to visualize and manipulate transcription factor gradients that direct intestinal cell cycles providing unprecedented insights into how cell cycles are timed finally i will analyse the mechanisms that control cellcycle behaviour in p redivivus a related nematode in which intestinal cells undergo a slightly different cellcycle pattern expanding our analyses to this species will empower us to investigate how cellcycle patterns can diversify to generate phenotypic variability together this research program will develop a mechanistic understanding of the temporal control of cell cycles in development revealing new paradigms on how tissuespecific division patterns arise this knowledge will open up future avenues to modulate cell cycles for tissue engineering purposes as well as to control cell divisions in disease
safe food in a world of changing climate the doctoral training programme to develop novel control mitigation and risk assessment methods for biotoxins

there is a massive and urgent need to ensure security and safety of the food supply of the growing world population the ongoing war in ukraine as well as the energy crisis emphasized this even further however agriculture and food industries continue to be vulnerable to problems of contamination with biotoxins produced by plants algae and particularly by fungi global warming and extreme weather events make the occurrence of these toxic metabolites even less predictable alarmingly the eu currently faces a lack of food safety specialists as recognised by the european commission these challenges lay the foundation for biotoxdoc safe food in a world of changing climate the doctoral training programme to develop novel control mitigation and risk assessment methods for biotoxins the objective of biotoxdoc is to train doctoral students phds in a broad range of skills and complementary competencies necessary to innovate various scientific fields and approaches so urgently needed to control and mitigate biotoxins by taking advantage of a multidisciplinary multisectoral team of worldclass experts the training and research will include development of early warning systems and onsite testing by portable mass spectrometry phds will develop novel detoxification strategies of biotoxins and will assess the combined toxicity of cooccurring biotoxins moreover phds will develop muchneeded rapid as well as confirmatory tests for biotoxins and aim to close major gaps in our current knowledge of biotoxins the major common link between all phds working on a wide range of biotoxins at different points along the food and feed chain is the influence of climate change on biotoxin occurrence and the resulting demand of revised strategies to mitigate its impact on the european population
reconstructing enzymes for novel nitrogennitrogen bond forming chemistry

nitrogennitrogen nn bonds have fascinating structural and functional properties are ubiquitously found in diverse pharmaceuticals and fine chemicals and represent important key structural motifs in diverse natural products endowing them with potent biological activities however traditional chemical procedures to synthesize nn bondcontaining compounds are often difficult to realize costly and environmentally unfriendly in addition the formation of intermolecular nn linkages is particularly difficult and remains a mostly unaddressed problem in chemistryrecnnstrct will address this challenge by decoding novel reaction chemistries from the underexploited family of nn bondforming enzymes nnzymes while tackling reactions that are difficult to realize by traditional chemical approaches and currently not feasible by enzyme catalysis as such recnnstrct aims to break new ground in chemical synthesis it will develop an enzymatic toolbox for versatile nn bondforming reaction chemistries by exploring naturally promiscuous and redesigned nnzymes for diverse intra and intermolecular as well as nonnatural nnbond formations to achieve this recnnstrct will combine methodologies from enzyme catalysis and evolution genome mining and the latest achievements in bioinformatics in this way recnnstrct will not only establish the chemistry performed by the enzymes it will also elucidate enzyme structures catalytic mechanisms and design biocatalytic cascades to showcase the potential of tailored nnzymes recnnstrct will thus revolutionize our synthetic strategies and aims to substantially contribute to a greener chemical industry by creating versatile catalytic platforms for nn bond formation leading to streamlined routes to highvalue chemicals beyond this groundbreaking direct impact in the field of enzyme catalysis recnnstrct will boost the clinical and research environment by providing new biocatalysts for future drug discovery efforts
unveiling convergent adaptation in mediterranean pines to inform a new tool for the management of forest genomic resources

the impact of climate change on forest species is predicted to be dramatic due to the insurgence of adaptive lags between the current genetic makeup of populations and the newly established climatic conditions the consequent disruption of local adaptation is of concern as plants may not be able to readapt or migrate fast enough which could inflate genetic erosion eradication and extinction ongoing conservation efforts are currently devoted to the characterization of forest genetic resources with the aim of maximising adaptive potentials and increasing the chance for forests to tackle future conditions here medforact will focus on three iconic pine species native to the mediterranean basin pinus halepensis p pinaster and p pinea to identify a core set of genes and gene networks that may have fostered their convergent adaptation in the face of compelling ecological challenges and despite million years of independent evolution to tackle this challenge the project will use a newly produced genomic dataset composed of c 800 individuals genotyped at c 100k snps representing both neutral and adaptive variation detecting signatures of convergent adaptation could highlight the adaptive potential of these species with implications for the development of genomicinformed management strategies and setting conservation priorities based on predicted climate change scenarios following this medforact envisages using the detected topranked candidates to develop a new software for forest management with the aim of providing forest managers with a practical means of implementing targeted reforestation approaches by monitoring the expected adaptive lag of populations using genomics and future climatic predictions
stateoftheart sustainable energy efficiency technologies roadmap for waterborne transport towards the fitfor55 guidance compliance

fleetfor55 is an ambitious project to align the european waterborne sector with the eus fit for 55 environmental targets for 2030 this will be done through a holistic roadmap that identifies the most cost effective and sustainable implementation of energy efficiency technologies eets onboard short sea inland waterway and high seas vesselsto achieve this fleetfor55 will evaluate eets paired with new vessel designs and retrofits collectively defined as use cases six retrofit use cases and four new vessel design use cases each employing a designforoperation approach will be optimised for both energy use and environmental compliance throughout each use cases lifetime and for different operational scenarios additionally the project will integrate a decision support system into a webbased digital platform to rapidly assess and benchmark use cases achieving quantifiable energy efficiency savings and reduced emissions this system assesses use cases with the help of key performance indicators that align with the eus fit for 55 legislative package and the international maritime organizations indices such as ciidcs eexi and eedikey strategies include developing detailed business models for each use case to ensure market adoption and the establishment of the technologies innovation network the latter will ensure that eets are effectively matched with end users promoting the adoption and practical implementation of new technologies in the waterborne transportation sectorthese initiatives position fleetfor55 not only meet stringent eu environmental standards but also to set a new benchmark for future environmental excellence in waterborne transportation