Dragon09/odtu_chatbot huggingface dataset:
views a political violence early warning system

this application presents a plan to explore the societal potential and financial viability of views a political violence early warningsystem which has been developed as part of the ercadg project no 694640 at the department of peace and conflictresearch uppsala university and peace research institute oslo prio it is a rigorous and transparent prediction system of unprecedented scope and performance that is positioned at the forefront of research on theoretical and methodological foundations for highquality forecasts of political violencethe proposal describes how the research from the adg project as well as research conducted as extensions to the adg project in collaboration with the unhcr un escwa and uk fcdo can be applied to maximise the usefulness of the forecasting system for individuals and organisations that are dedicated to conflict prevention and mitigation while simultaneously strengthening the systems focus on transparency and openaccess publication strategiesplanned activities include measures to solidify views reputation as a highquality opensource earlywarning system andstrategies to transform views into a financially viable and selfsustaining entity the proposal also details concerted efforts to clarify our ipr position and strategy incorporate recent userspecified developments into the earlywarning system built under the adg project apply a usercentric approach to evaluate the predictive performance of the forecasting system as a complement to current evaluation metrics and a number of activities aimed at assessing validating and maximising the usefulness of the projects outcomes to the full target audience
should we prohibit luxury emissions of greenhouse gases on top of price constraints

many share the intuition that the luxury emissions of the global top 1 are morally wrong given the current state of the climate crisis yet the subsistenceluxury distinction has been used so far to justify a right to subsistence emissions rather than a ban on luxury and extravagant emissions prohiblux aims to develop a carbonlimits theory of emissionpermits distribution ie an ethical theory that clearly identifies luxury emissions indipendently of subsistence emissions and justifies their proibition prohiblux research is developed in three stagesfirst the candidate will analyse three possible ethical arguments that can support the carbonlimits claim the axiological argument the imageexternality argument and the moralcorruption argument each argument will be tested against two main objections the offsetting objection and the coercion objection second the candidate will provide identification criteria for carbon limits based on the ethical arguments that pass the objections test and he will address any mismatch by devising an integrated grid of identification criteria third the candidate will lead an ethicsandpolicy analysis of different implementation policies of carbon limits taking also into account the risk of luxury carbon leakage a ban a luxury carbon tax and a notrade individual cap through the training program the candidate will qualify as a researcher at the intersection of ethics and climate policies and acquire new skills related to income and funding generation project management student supervision and scientific communication prohiblux will contribute to the philosophical debate on climate change proposing a new critique of carbon inequality as an alternative to egalitarian utilitarian and subsistencebased arguments prohiblux will contribute to a fair and inclusive transition by developing policyready guidelines for the just implementation of carbon limits
simple and costeffective cancer diagnosis in liquid biopsy through native trna sequencing

transfer rnas trnas are abundant heavilymodified small noncoding rnas that play a pivotal role in decoding genetic information determining which transcripts are highly and poorly translated at a given moment dysregulation of trna abundances and trna modifications is a wellknown feature in cancer cells leading to enhanced translation of specific oncogenic proteins despite the wellestablished association between trna dysregulation and cancer progression and malignancy trna abundances and their modifications are still not being used as diagnostic or prognostic markers for cancer detection or progression mainly due to the lack of a simple unbiased and costeffective method to quantify trna abundances and their modifications our laboratory has recently established nanotrnaseq a pioneering method that can accurately quantify both trna abundances and trna modifications using native trna nanopore sequencing for a fraction of the cost of nextgeneration sequencingbased approaches by employing a proprietary nanotrnaseq nanopore library preparation protocol coupled with deep learning algorithms that will rapidly classify the nanopore current signals here we aim to establish a method that exploits trnas as novel biomarkers through the use of third generation sequencing technologies we have initial evidence of how our approach can separate cancer from noncancer samples and possibly be used to identify the tissue of origin in this project we will fully validate our technological platform for the differential analysis of lowinput rna amounts in liquid biopsy samples we will initially apply our method in the cancer arena expandable to many other indications following the advice of key stakeholders contacted so far with the goal of laying the basis for the transfer of our technology to the marketplace including through the creation of a new startup company
power electronics optimisation for next generation electric vehicle components

with the purpose of transforming road transportation in europe to zeroemission mobility powerdrive aims at developing next generation highly efficient costeffective and compact power electronics solutions that integrate a portfolio of technologies for multiobjective optimisation of electric powertrains of battery electric vehicles these integrated solutions can be applied to both low and highperformance vehicles and they will be suitable for diverse types of electric vehicles the concept of powerdrive is that all the experience and expertise of the project partners in the development of electric drivetrain components will be leveraged and lead into the integration of advanced power electronics solutions for an optimised powertrain this concept brings additional opportunities to strengthen europes supply chain in electromobility for road transportation and to achieve zeroemission road mobilitypowerdrive intends to implement innovative strategies to improve the efficiency and power density as well as to reduce the cost of electric powertrains while keeping performance high and reliable the technologies developed in powerdrive will accelerate the development and deployment of zeroemission road mobility which will deliver concrete benefits including improved quality of life economic growth and new business opportunities for all the eu member states an optimised ev powertrain will significantly reduce transport emissions and tackle the issues of air quality and noise pollution in urban areas
gendered innovation living labs

gill coordinated by enoll the largest network of living labs ll will develop a paneuropean collaboration and learning hub based on the ll principles to become the open innovation framework for all european actors for open gendered innovation the gill ll will cocreate sustainable mechanisms to increase gender responsive smart innovation and entrepreneurship grise by fixing practices and culture across the european ecosystems gill will focus on 4 macroobjectives a to enable the organisational and cultural changes b to enhance professional development c to increase the integration of gender and diversity into product design technologies and innovation and d to allow gendered educational practices in parallel gill actions will act along a matrix of horizontal spheres of innovation individual team tools methods innovation products societal processes and three vertical priorities health and resilience green digital transition gill will be implemented through an iterative cocreation approach structured on a fourphases cycle understand codesign implement evaluate repeated twice to incorporate the feedbacks and evaluation results in finetuned and validated results 15 actionoriented experimentations in 8 european countries will develop new approaches to grsie test evaluate the changes and thereby validate gills outputs in reallife open ecosystems through this cycle gill will deliver a systemic review of barriers to grsie leading to the codesign of proven methodologies services and tools for grsie to be made available on a sustainable and easy to use platform in line with the ll methodology cocreation and open innovation will be fostered among the main actors of the quadruple helix model citizens government industry and academia who will be engaged all along the project through different participatory activities
how varieties of nationalism shape our polarized politics

this project examines how nationalism polarizes the electoral politics of advanced democracies how it drives us apart and whether it could bring us closer together across advanced democracies concerns over deepening divisions have proliferated in recent years and national identities have emerged as a prime suspect in driving this polarization according to the common framework in electoral politics research this polarization is shaped by a transnational cleavage that has at its core a cultural conflict between national attachments and universalist values varnatpol proposes a different perspective that the dividing lines structuring our politics are drawn not between those with stronger and weaker national attachments but rather across groups who subscribe to different varieties of nationalism to assess how varieties of nationalism shape polarization varnatpol theorizes and empirically investigates how national identities are linked with mass attitudes and commitments to democratic norms map onto partisan identities and provide opportunities for political mobilization varnatpols theoretical approach calls for a multimethod comparative research design the first work package analyzes novel survey data to investigate how common understandings of nationalism in the public shape partisan divisions and includes methodological innovations using openended survey questions to study national identities the second work package examines how elites differ in their efforts to mobilize support based on appeals to the varieties of nationalism identified in the first work package the third work package explores whether elite appeals to national identities shape polarization through their effect on public opinion and partisan hostility challenging the common wisdom regarding the ways in which nationalism polarizes the electoral arena varnatpol will contribute not only to academic research but also to public debates about the challenges facing our societies
probing orphan nuclear receptors in neurodegeneration

neurodegenerative diseases such as alzheimers parkinsons or multiple sclerosis are severe health burdens and major global challenges for societies and healthcare systems therapeutic interventions in these diseases are not satisfying since there is no treatment strategy that can halt or reverse disease progression several failed attempts at finding a cure for neurodegeneration have significantly reduced the interest for further research yet more than ever new approaches are needed critically missing are pharmacologically validated targets for efficient neurodegenerative disease treatment and it is exactly here that neuroprobe aims to close this gap the orphan nuclear receptors nr tailless homologue tlx and nuclear receptor related1 protein nurr1 have been identified in knockout studies as prime candidates however ligands for their pharmacological control as tools for therapeutic validation are lacking neuroprobe will enable pharmacological modulation of these transcription factors as a new and groundbreaking strategy to counteract neurodegenerationto meet its overall aim neuroprobe will 1 develop chemical probes cp and protacs for tlx and nurr1 2 employ generative artificial intelligence ai for molecular design to accelerate cp and protac development 3 establish phenotypic cellular models in 3d settings to mimic neurodegeneration and 4 use cps and protacs in the phenotypic models for pharmacological control of tlx and nurr1 to validate their modulation in neurodegenerationthis challenging and highly multidisciplinary endeavor will profit from my strong interdisciplinary background in the field of nr ligand discovery and pharmacology as well as in aibased molecular design neuroprobe will open new avenues towards regenerative treatments in neurodegeneration close the gaps in pharmacological control of tlx and nurr1 and substantially contribute to consolidating ai techniques for structural optimization
open modelling toolbox for development of longterm pathways for the energy system in africa

openmod4africa aims to develop an open toolbox populated with stateoftheart models for analysing longterm pathways to sustainable secure and competitive energy systems in africa the toolbox will build on eu projects like open entrance plan4res and focusafrica and will adapt and further develop open models in accordance with the african context and needs the models are scalable and can be applied to cities industries and countries furthermore a main objective for openmod4africa is capacity building among energy models in academia four african universities will be actively involved in adapting models and conducting two regional case studies the additional capacity and the open toolbox will enable the universities to train new generations of energy modelling experts for the energy industries in africa three decisionmakers will also be engaged together with a network of energy industries and universities in 25 african countries these players will be invited to use the toolbox and to be involved in training activities they will also be invited to a permanent network of expertise which will be developed for further capacity building and collaboration beyond the project two case studies will develop energy pathways for rural areas cities countries and large regions of countries in western and eastern africa the replication strategies will pave the way for further analyses beyond the project finally openmod4africa aims to collaborate with other ongoing initiatives to maximize the impacts of the project and create synergies the consortium consists of 15 partners and 2 associated partners eight partners are african important longterm impacts from the threeyear project include enabling academia and decisionmakers in africa to conduct their own analyses for the optimal development of their energy system supplying energy to a much larger share of the population and establishing a system based upon the abundant share of renewables on the continent
mimic human complexity in a beat to revolutionize the drug development

biomimx beating organsonchips ooc are in vitro miniaturized and living replica of human organs and diseasesbuilding upon cuttingedge technologies and human cells beating ooc provide a faithful replication of native humanphysiology integrating miniaturized 3d cell culture techniques mechanical stimulation ubeat and electrical recordingcapabilities usense biomimxs proprietary key technology ubeat supports 3d human cell cultures and integrates acontrolled and tunable mechanical stimulation system ubeat leads to the generation of mature and functional miniaturizedreplication of human organs adequate to test compounds toxicityfunctionality in a highthroughput fashion integration ofusense allows realtime evaluation of clinically relevant parameters from the established beating models biomimxsbeating ooc represent a safer more efficient and faster alternative to poorly predictable preclinical models to date available inthe drug discovery pipeline ddp biomimx already demonstrated the validity of its beating ooc models in two critical fields ofthe drug discovery pipeline uheart human beating heartonchip has been applied as early predictor of drug functionalcardiotoxicity uknee first in vitro model of human oa has shown its predictive potential for the discovery of new targets foran unmet pathologyalso thanks to the contribution of women techeu programme biomimx aims at demonstrating the unprecedented potential of its disruptive innovation in reshaping the market of drug development by i boosting technological aspects ie through an intensive industrialization process of biomimx patented technologies and ii proving the versatility of its innovation and its capacity to adapt to a manifold of indications and market spaces in line with the 3r principle biomimx final vision is to reduce and eventually replace animal experimentations within the next 15 years
large earth observation new space ecosystem ground segment

leonsegs is a federated environment called multimission earth observation ground segment service platform of eo data providers that collaborate all together through harmonized interfaces and that are managed by a central automated multimission service able to coordinate and produce for the enduser complex eo product there are different types of eo data providers eo products provider like for instance existing eo constellation operators that offer their data and products and eo satellite constellations satellites that are managed by a ground segment as a service gsaas solution and that allows not only access to data and products but tasking of future acquisitionsthe proposed multimission ground segment shall federate new space players supporting the heterogeneity of the new space ecosystem through harmonized interfaces for each profile and especially withnew space stakeholders which need or wish to externalize their ground segment infrastructureseo existing products providers with their own space and ground segment willing to access to the market that this infrastructure will offerleonsegs is a multidisciplinary fully complementary consortium gmv has an extensive experience in coordinating international collaborative research projects and is the worldwide leader in ground segments plus is a highly reputed academic partner with a cutoftheedge experience on eo processing satl is a new space leader in eo operating a proprietary constellation of highresolution satellites capable of imaging earth in high frequency f6s is one of the best companies with expertise on community building dissemination communication especially for engaging with stakeholders f6s runs actually a world community platform with more than 45mil users and approximately 15 mil techstartups
bringing 3d cardiac tissues to high throughput for drug discovery screens

1cardiovascular disease is the number 1 cause of death worldwide novel cardiovascular drugs have a high failure rate of 91 in clinical trials this failure rate is due to lack of proper cardiac models used to find new drugs drug discovery studies rely mainly on 2d culture models which have insufficient predictive value of the human heart a new in vitro 3d model has been developed by assembling human cardiomyocytes into a threedimensional strip configuration 3d cardiac strip that better mimics the native heart tissue however this system is not compatible with the high throughput setting needed to perform drug discovery screens river biomedics has found a unique solution to miniaturize the human 3d cardiac strips and use them in a highthroughput assay we combine two innovative technologies human induced pluripotent stem cell hipsccardiac cells and microfluidic systems the opentop microfluidic technology developed in the group of prof vd berg from the university of twente enables the culturing hundreds of culture chambers automatically and consistently which is key in high throughput screens this technology will enable the production and culture of 3d cardiac strips in large numbers bringing 3d vitro models into a high throughput scale the end users of this technology are pharma companies performing drug discovery activities and cros providing drug discovery services for commercialization of 3dcardiachts we plan to partner with an enduser and assess their requirements for the use of such high throughput technology with the intention of securing their partnership at the end of the project in parallel we will discuss the various partnering options with identified potential pharma partners andor cros the best financial deal structure for partnership on 3dcardiachts and consequently validate the best business model to pursue the commercialization of 3dcardiachts
developing ethical abstention contextualism

the research projet developing ethical abstention contextualism devethac deals with the ethics of electoral abstention ie the ethics of voluntary nonvoting in political elections by enfranchised citizens the project specifically addresses an existing view in electoral ethics that it calls ethical abstention contextualism and that is to the effect that abstention is ethically permitted in some circumstances but not in others looking to elaborate and bolster this particular view devethac examines how ethical abstention contextualism should evaluate the forms of electoral abstention that are most characteristic in practice eg abstention by young citizens abstention by poor citizens abstention in nonproportional election systems etc devethac further seeks to flesh out the ethical bottomline responsibilities that ethical abstention contextualism should ascribe to individual citizens when different circumstances coincide in one and the same election causing abstention to seem both pro tanto permissible and pro tanto prohibited and devethac thirdly aims to clarify what ethical abstention contextualism implies for how electoral systems should receive and register abstentions notably devethac aims to understand how abstention contextualism assesses electoral systems that simply count and report abstentions and how it evaluates electoral models in which abstentions are instead rendered politically consequential eg through the use of quorum rules or other institutional devices by pursuing these three research objectives devethac strives to elaborate and strengthen a philosophical position that enjoys prominence in the electoral ethics research debate but remains undertheorized nonetheless additionally the project aims to further the general publics ability to normatively asses current patterns of electoral abstention and its ability to gauge how democratic electoral systems might respond to those patterns