Dragon09/odtu_chatbot huggingface dataset:
deciphering the role of surface mechanics during cell division

cell division is fundamental for all life forms and its dysregulation can lead to severe diseases including cancer the dramatic shape changes eukaryotic cells have to undergo to divide are mostly driven by the cell surface a complex system that can dynamically modify its mechanical properties while the importance of physical cues for cell division has long been recognized the lack of specific tools that modify particular physical properties and bridge moleculartocellular scale biophysics prevent us from understanding how cells use their mechanics to regulate form and function to address this my group has recently developed a new class of molecular tools that for the first time allows us to manipulate surface mechanics specifically and acutely in living cells exploiting this powerful new structural biophysics approach our first discoveries excitingly demonstrate that the strength of tethering between the plasma membrane and the cortical cytoskeleton is a key control mechanism for cell division both in cultured cells as well as in mouse embryosthe overarching goal of mitomechanics is to systematically understand how cell surface mechanics controls the different steps of division my team and i will systematically and quantitatively link cell surface architecture with the resulting mechanics and morphology to determine the structurefunction relationship at the cellular periphery in space and time to this end we will deploy novel molecular tools and combine them with cellular biophysical measurements super resolution microscopy and in situ cryoelectron tomography moreover we will build datadriven theoretical models to unravel the physical principles that control the membranecortex interface and test their predictions with novel optogenetic tools our project thus takes a highly interdisciplinary approach combining mechanobiology molecular engineering structural analysis and theory to decipher how cells their mechanics to control mitosis
determinants of island ecological complexity in the context of global change

biodiversity is declining globally at an unprecedented rate representing 30 of the biodiversity hotspots islands are particularly vulnerable to anthropogenic activities indeed 80 of reported extinctions are island species yet unique island biodiversity which includes not only the species but also the myriad of interactions among them is still greatly unknown it is thus urgent to describe it and forecast the consequences of its annihilation so we can mitigate the effect of further losses detecting ecological interactions and understanding their complexity is however one of the big challenges in the natural sciences the advent of new theories and analytical tools such as critical transition theory and complex network analysis provides hope to reach that goal as relatively simple systems with welldefined borders islands have a great potential to advance our comprehension of nature complexity islandlife will provide the most comprehensive and quantitatively sophisticated study of multilayer networks to date in any terrestrial ecosystem we will focus on five archipelagos encompassing four oceans and a wide latitudinal gradient comparing for the first time the food web structure of pristine littledisturbed islands of a few km2 with areas of similar size in nearby disturbed humaninhabited islands the objective is to unveil the unique biodiversity of these ecosystems understand their complexity and evaluate their fragility to global change drivers such as biological invasions we will combine direct observations during intense fieldwork automatedvideo monitoring and deeplearning cuttingedge molecular techniques and newly developed coextinction models to predict persistence and resilience of island biota to disturbances the project will represent a major breakthrough towards understanding the effects of global change on these valuable ecosystems of great relevance to both theoretical ecologists and applied conservationists
green biorefarmeries smallscale circular green biorefineries for increasing farmer sustainability and competitiveness and building resilient rural areas

rural biorefarmeries brings together farmers industries and other partners across europe to demonstrate a farmercentred bioeconomy model aimed at maximizing the potential of europes vast grasslands the project will demonstrate a novel smallscale decentralized rural green biorefinery value chain which addresses the limitations of existing green biorefineries this smallscale decentralized model places farmers at the centre of the biomass value creation close to their farms allowing them to coproduce inputs for their farms with additional high valueadded intermediates and products which will be further developed in collaboration with centralized facilities and downstream industry partners the model provides a practical implementation of the bioeconomy among a large farmer cohort and builds on the existing farm enterprises and cooperative structures of our partners enabling collaboration scaleup market access and building synergies across primary and industrial sectors the project advances stateoftheart for green biorefinery in terms of operational model logistics processing product development and assessment methods which collectively deliver a more sustainable and profitable model for farmers and rural communities the model will serve as a blueprint for farmers to sustainably diversify into the bioeconomy reducing their farm emissions while creating new products which displace unsustainable alternatives in a range of agrifood markets rural biorefarmeries model will be replicated to diverse regions of europe supported by the development of inclusive business models and handson training among multiactor groups and communities in regions of high potential the project represents a highly replicable model for europes abundant grasslands helping farmers to deal with sustainability and profitability challenges while helping rural communities to become more resilient while realizing the potential of their local bioresources
fostering fair data and standards in rare hematological diseases

research on rare diseases rds is scarce and fragmented in the eu leading to delayed diagnoses limited availability of medicinal products and challenging access to care like in most rds datadriven research on rare haematological diseases rhds is affected by the lack of data standardisation and the fragmentation of available data in close repositories adhering to the principle of making data findable accessible interoperable and reusable fair is pivotal in fostering collaborative research and maximising the potential of available data fair principles are especially relevant in the context of rd research as their use can help to tackle data fragmentation and accelerate scientific discoverieshemafair aims to unravel the scientific excellence and innovation potential of a widening country cyprus through an eu network of excellence on the use of fair principles in rhd research as a reference centre for most rds in cyprus the cyprus institute of neurology genetics cing can serve as a model for raising the scientific profile and competitiveness of cyprus in rdsrhds and biomedical informatics and strengthening the research management and administrative skills hemafair brings together key experts in rhd research biomedical informatics patientcentred research and ethics and regulatory issueshemafair will develop and implement a comprehensive training programme and numerous capacitybuilding and strategic networking activities including summer schools workshops webinars and transferrable skills lectures also hemafair will raise the profile of earlycareer researchers via the development of a mentoring programme shortterm staff exchanges and three collaborative research projects notably the research component of hemafair will demonstrate the fairification process on two existing platforms for haemoglobinopathies a group of rhds that are particularly prevalent in cyprus thus maximising the impact of the project on the local society
piloting open and responsible activities and trainings towards the enhancement of researchers networks

pattern is a 42months coordination and support action whose aim is to promote the practice of open and responsible research and innovation by developing and piloting training activities for researchers at all stages of their careers these trainings will strengthen their transferable skills with the ultimate goal to empower higher education institutions and research organizations to embrace a transformative process to improve the excellence of the science conducted the capacity within the european research area to tackle societal challenges and the interaction between science and society pattern work plan consists of specific and interlinked activities each of them implemented in the framework of a consistent methodology based on 4 subsequent running phases and one horizontal holding phase state of the art consolidation of knowledge rp1 developing pattern training activities and platform rp2 testing pattern training modules rp3 evidence for policy development rp4 cocreation and codesign hp i a mapping and analysis activity will take care of highlight the state of the art of learning opportunities for researchers on open and responsible research and innovation identifying the potential for new training activities for researchers at all stages of their careers wp1 ii based on the mapping training materials with be produced along with a training and discovery platform that will enable learners to easily access and make use of those materials in the longterm wp2 iii the new training modules will be then piloted and evaluated to further refine them wp3 iv policy recommendations for researchers training on open and responsible and innovation practices will be designed building on the results of undergone activities wp4 v dissemination communication and engagement activities wp5 will then assure widespread outreach of the projects results and outcomes and to reach its impacts
edv2209 a paradigm shift in the treatment of stroke

despite tremendous research efforts and a large number of clinical trials focused on developing treatments for stroke the fields current state remains dismal there are at present no efficient treatments nor promising drug candidates for this lethal and disabling condition a different perspective with a new approach is therefore desperately needed edvinces drug discovery and development is born out of founder and professor lars edvinssons extensive fundamental and pioneering research of cerebral circulation receptor regulation stroke and migraines edvince is now ready to conduct the first clinical trial in 2022 with its innovative and disruptive lead drug edv2209 an orphan drug for the treatment of brain ischemia associated with severe subarachnoid hemorrhage sah the drug helps to keep the blood vessels in the brain open allowing brain cells to receive oxygen and nutrients to prevent brain damage
build scaled modular bambooinspired offshore solar systems bamboo

bamboo tackles the barriers for the implementation of a sustainable largescale offshore floating photovoltaics fpv system of 1 km2150 mw that will act as a blueprint for rollout of offshore fpv projects in europe and that is to be implemented in conjunction with the offshore wind leading eu utilitypartner offshore fpv extends pv potential at enormous scales to make europe meet its climate targets for 2030 and 2050 it makes use of space at sea largescale economies of scale complementary energy yield with wind farms and it isa solution with potentially low impact on aquatic ecosystems however developing offshore fpv systems is technically challenging due to the harsh conditions of waves corrosive environments and economically not feasible yetproject bamboo addresses these challenges through four breakthrough innovations including1large floating surface understanding through worlds first basin scale tests and hydrodynamic modelling of 1 km2 blankettype arrays2a 5 mw demonstrator in the north sea with hybrid design encompassing the benefits of larger array protection in floaters3the offshore worlds first dynamic floating substation for offshore fpv and4the development of 6 worlds first standard offshore testing methodologies for key fpvcomponentsthrough assessments of energy yield circularity of materials environmental impact lca and endoflife strategies bamboo paves the way to scale offshore fpv systems to commercial and sustainable applications significantly reducing emissions while having a netpositive impact on the marine ecosystemthe consortium covers what is necessary to make bamboo a success companies including oceans of energy will provide the technologies rtos including marin and fraunhofer the assessment of the system and its environmental impact abs expertise on certifications and the industryleading utility the capacity to implement the largescale integration of offshore wind with fpv farms
deep exploration boosted by advanced exploration technologies

the project consortium of deepbeat aims to develop groundbreaking technologies to use geochemistry for the detection of deepseated land deposits transforming europes exploration sector by integrating cuttingedge technologies and sustainable practices will push europe towards a climateneutral and socially responsible economy the exploration of deep land deposits should employ environmentally friendly socially acceptable and ultralow impact methodologies to ensure the citizens that exploration activities can be conducted responsibly acceptance to exploration and mining will be a cornerstone towards cultivating a more resilient and inclusive european societydeepbeat final outcome will be a workflow which addresses these aspects by two means i deepbeat plans to engage with the local communities at the test sites to learn about concerns hesitancy and what is the emotional core of these experiences from these events will be included in exploration workflow as an integral part following the principles of free prior informed consent which requires to interact with communities at a very early stage ii deepbeat proposes ten novel technological developments all designed to minimize impact on environment and maximise sustainability these research and innovation developements have the potential to push the limits of surface geochemical exploration to an other level they comprise a new insights to ultrahigh resolution analytical chemistry b increasing sampling strategy efficiency c introducing groundbreaking new concepts of dealing with elemental measurement data d reducing exploration costs by sample selection e testing novel phytogeochemical media and f introducing uav assisted biogeochemical sampling detailed understanding of the deposits complement the workflow to allow the understanding of the mineralizations as part of mineral systems and aiassisted 3d mineral prospectivity modelling
dissecting the molecular mechanisms underlying hnrnp exclusion from dna doublestrand breaks

dna doublestrand breaks dsbs are toxic lesions that must be efficiently repaired to maintain genome integrity following dna damage cells activate a multilayered signalling and repair network termed the dsb response emerging organizers of this dsb response are various rnas and rnabinding proteins which display characteristic localization dynamics at the damagedchromatin the laboratory of stephanie panier recently showed that many heterogeneous nuclear ribonucleoproteins hnrnps are actively excluded from damaged chromatin soon after the induction of dsbs the exact purposes of hnrnp exclusion and the underlying regulatory mechanisms remain to be determined in my postdoctoral project i propose to study why and how hnrnps are excluded from damaged chromatin to this end 1 i will characterize the exclusion properties of the hnrnps at dsbs using cellular models and unique genetic and microscopy approaches 2 i will also identify protein and rna complexes associated with hnrnps at dsb sites using proximity labelling proteomics and rnasequencing approaches in studying these hnrnps i will unravel the new mechanisms by which rnas help to organize the dsb response the combination of stateoftheart cell biological and omic approaches will enable me to go well beyond the current knowledge of the field to characterize novel factors and mechanisms that coordinate rna biology at dsb sites since genome instability and defects in rna metabolism are both directly linked to the pathogenesis of cancer and also neurodegeneration my findings will have direct implications for human health
achieving the golden grail in solid tumor treatment

macrophage therapy is promising for solid tumor treatment as these cells are continuously recruited into the tumor mass even the most hypoxic regions our pioneering research demonstrated that macrophages are able to take up ferritins loaded with anticancer drugs creating macrophagedrug conjugates mdcs and transfer these to cancer cells and kill them a phenomenon we named train in my ongoing erc starting grant project mchap we have proven that mdcs can be sucessfully used not only to treat solid tumors but also to induce subsequent resistance to the tumor rechallenge acquisition of resistance to tumor development after specific therapy is a golden grail in oncologynow we aim to turn the mdc technology into a commercial and social value proposition by confirming mechanisms of tumorresistance in tumorbearing mice and identify immune response this is crucial to raise interest of and establish a codevelopment or licensing deal with big pharmas to realize commercialization and clinical uptake of our ipprotected mdc technology during the erc poc project we will perform highdimensional spectral flow cytometry spatial transcriptomics and singlecell transcriptomics of the tumor before and after mdc treatment to identify mechanisms of tumorresistance and optimize our business case this project will thus provide proof of concept for the immune activation after the mdc treatment and thus establish the viability feasibility commercialization and overall direction for our innovative mdc technology this project will substantially contribute to bring our mdc technology to the market and clinical practice
finding the identifiable species in shagreen multidisciplinary perspectives on marine shagreen and historical elasmobranch exploitation in europes early modern period

marine shagreen is a luxurious storied leather material made from the skins of elasmobranchs sharks rays skates admired for being visually striking waterproof and conveying a sense of worldliness shagreen became coveted by the wealthy and elites of 17th19th century northwestern europe crafted from shark or ray skin once turned into shagreen more precise taxonomic identifications are not possible provided the multinational origins the elasmobranch species targeted span the atlantic ocean to the indopacific finding the identifiable species in shagreen fins aims to use a multimethodological approach to analyse museum objects and unveil which species of elasmobranchs were targeted for marine shagreen production in europes early modern period historical archival research will be undertaken to refine our knowledge of anticipated target species while nondestructive and minimally destructive methods will be employed to directly analyse shagreen objects for taxonomic identifications understanding the historical exploitation trade and demand for elasmobranch skins in this time period which coincides with the rise of industrialised fishing efforts is critical and a timely endeavour to establish the ecohistory of these keystone taxa one third of all elasmobranch species are classified as being threatened with extinction by the international union for the conservation of nature a key challenge to ongoing elasmobranch conservation efforts is the lack of historical data and ecological baselines through a combination of biocodicology historical analysis ecological research interdisciplinary collaboration and innovative approaches we aim to provide valuable insights into the material culture environmental history and ecological dynamics related to elasmobranch exploitation during this period
vitnk deciphering vitamin a and d regulation of human nk cells for cellular immunotherapy

natural killer nk cells are cytotoxic innate immune cells that defend against viral infections and cancer as cancer is one of the leading causes of death worldwide more effective treatment options are urgently needed harnessing nk cell cytotoxicity for cancer treatment shows promise but there is still room for improvement particularly against solid tumours which are difficult to treat due to challenges such as limited tumour infiltration therefore identifying targetable factors that enhance not only nk cell development function expansion and persistence but also homing and migration are crucial to optimize cancer immunotherapies vitamin metabolites retinoic acid ra and calcitriol ca activate nuclear receptors rar rxr vdr and regulate differentiation function and homing properties of t cells and ilcs in the vitnk project i will systematically investigate how ra and ca as well as their nuclear receptors impact human nk cell development differentiation function expansion survival and migration to achieve this haematopoietic stem cellbased nk cell differentiation cultures and shortterm peripheral blood mature nk cell cultures will be used indepth analysis of the changes induced by vitamin metabolite supplementation and crisprmediated nuclear receptor knockout using advanced cellbased assays in combination with cuttingedge single cell rna atac and chipsequencing will give a comprehensive insight into the molecular mechanisms that are governed by vitamin a and d in human nk cells vitnk will thus establish how vitamin a and d modulate nk cell homing and migration which is essential for efficient tumour infiltration the purpose of vitnk is to take initial preclinical steps towards therapeutic targeting by thoroughly evaluating the potential of vitamin a andor d to upgrade nk cellbased immunotherapy for solid tumours paving a way for my future research career
revolutionary therapeutic treatment for stopping progression of parkinsons disease

parkinsons disease pd is a common neurodegenerative disorder affecting over 10 million people worldwide whereof 12 million in the eu this chronic disabling disease affects the central nervous system causing severe motor and nonmotor symptoms the high disease burden for patients and their family also comes with a big price tag for society which is expected to increase dramatically with an ageing population in eu the annual cost is 14 b currently the causes of pd are unknown and there is a broad spectrum of pathologies that ultimately lead to the loss of dopamine producing neurons in the brain the current dopamine substitution treatments alleviate some of the symptoms however there is no cure for pd nor any diseasemodifying therapies herantis has developed a new pharmaceutical her096 with the ability to affect pd pathology and potential to revolutionise the treatment of pd thus alleviating the huge burden it now causes patients and healthcare
hydrozine generator for zeroemission power on demand

denss mission is the creation of highly reliable power sources that provide renewable and zeroemission power everywhere based on a patented technology we develop and build reformers that provide clean and affordable hydrogen gas h2 via the conversion of hydrozine or otherwise known formic acid a liquid sustainable hydrogen carrier with dens x4 we introduce the worlds first commercially available hydrozine stationary power generator where our proprietary reformer transforms hydrozine into h2 gas and subsequently supplies a fuel cell for electricity generation on demand it is an excellent replacement of high polluting diesel generators as zero harmful substances like co2 nox sox soot and noise are emitted into the environment while emissions from the fuel consumption are the building blocks for the hydrozine itself making it a 100 renewable fuel