Dragon09/odtu_chatbot huggingface dataset:
scientific societies and the globalization of science 19301990

science has become a global enterprise to produce knowledge scientists with different nationalities gender backgrounds ethnicities and sociopolitical views engage in debate and adopt shared codes of conduct eg leaving out personal bias when evaluating each others work this project conducts historical research into the mechanisms that structure these global social relations within science by using 20th century scientific societies as its lens it hypothesizes that these hitherto unstudied societies have played a regulatory role in the globalization of science by acting as gatekeepers simultaneously opening up and limiting access to subgroups such as women scholars or scholars from the global south by organizing massive conferences selecting speakers allocating prizes electing boards etc building on studies of gender and ethnicity in science and on sociological analyses of evaluation in science global academies innovates the concept of scientific sociability to include unspoken codes of conduct that could establish divisions within scientific groups allowing the study of societies mechanisms of in and exclusion of setting implicit standards and their strategies for coping with political dissent the project innovates methodologically by engaging in multisited research into scientific societies in the usa france india and brazil and at the international level and by using multiple research methods journal analysis archival research and oral history in which presentday scientific societies are involved as stakeholders the project aims 1 to develop a conceptual toolkit for scholars across the humanities and social sciences to understand scientific societies formats standards and customs in relation to scientists group behavior and 2 to set a new historical framework for understanding the role of scientific societies in science foregrounding issues of gender ethnicity and geopolitics in an era of decolonization
the emotional aspects of resistance and solidarity

gender and racial discrimination are critical and pervasive problems in academic institutions worldwide apart from being underrepresented in some fields such as stem and philosophy gender and racial minorities are disproportionately vulnerable to sexual and racial harassment in higher education in 2021 a report on universities in the uk determined that women were nearly twoandahalf times as likely to experience sexual violence as men while staff on insecure contracts those with disabilities lgbtq or black asian or minority ethnic were also at greater risk academic institutions have sometimes sought to remedy to these exclusions by implementing diversity policies aimed at increasing the number of underrepresented groups among staff and students however and more problematically even when diversity policies and measures to fight against sexual and other forms of harassment are in place academic institutions tend to be more concerned with protecting the institution from reputational damage than with the safety and wellbeing of the victims reports that document the extent of these harms in universities point out that a change of culture is needed if we do not address the cultural environment that feeds these violent forms of exclusion diversity and antiharassment policies will be insufficient however as long as we do not understand what makes this culture so persistent we will lack the appropriate concepts and tools to change it my contention is that while sexual and racial harassment are among the most harmful and violent manifestations of oppression they are rooted in an ecosystem of cognitive and emotional habits that sediment in exclusionary practices against minorities my research project will be especially concerned with addressing these emotional conditions by asking how oppressed and oppressors need to engage with their emotions in order to resist against oppression and build more cooperative ways of living together
sarscov2induced activation of pathogenic endogenous retrovirus envelope hervw towards personalized treatment of covid19 patients

severe covid19 disease and the high frequency of its longterm complications are now a major health problem worldwide due to the significant heterogeneity of covid19 disease profiles biomarkers that allow either the identification of patients at high risk for developing severe forms of covid19 and its longterm complications or guide personalized treatment options are scarce the hervcov project aims to analyze the role of human endogenous retroviruses hervs known for their high proinflammatory potential in the immunopathogenesis of covid19 and to identify and evaluate a set of biomarkers which will be important for the diagnosis prognosis and followup of covid19 patients and their prioritization for targeted therapy recent data from the consortium has demonstrated that hervw envelope protein is highly expressed in lymphocytes of covid19 patients and correlates with inflammatory markers and respiratory outcome of the disease strongly suggesting the role of hervs in covid19 pathogenesis the project aims to assess the biological pathways and functions that underlie the association of herv expression and activation with severe covid19 forms and related complications biomarkers based on herv pathogenic protein activation sarscov2specific immune responses cytokine production and mandatory medical blood analyses for covid19 clinical monitoring will be studied in samples from different forms of covid19 acute post neuro and longcovid patients parameters will be determined that predict the clinical course of the disease and aggravation of sarscov2induced symptoms and allow potential clustering of different bioclinical profiles of covid19 patients diagnostic and prognostic panels translated from our fundamental research and subsequent evaluations of hervassociated biomarkers will be assessed to define novel indicators in precision medicinebased therapeutic strategies leading to individualized medical treatment in covid19
driving sustainable climate transition of videoondemand platforms at a time of transformation

the overarching goal of streamscapes is to kick start a new era in forward thinking and doing in the ways in which production consumption and decisionmaking systems in the cultural and creative industries ccis lead through the sustainable climate transition sct with a particular emphasis on videoondemand vod platforms as central nodes within audiovisual and cultural ecosystems specifically streamscapes will provide i an interdisciplinary mapping and assessment of the ways in which it is possible to substantially green the operations of vod platforms in the ccis ii pilot the transformative impact of vod platforms to engage in blue skies generation of ideas through a hubs based approach in the form of a future studies approach with a special focus on children and youth and iii cotest the potential of vod platforms to contribute to the sct in line with the european industrial strategy and the european green deal to achieve this a multistakeholder team of four core academics and eight key stakeholders including several european vod platforms combines original data and knowledge and collated best practices streamscapes among other things a develops robust methods to measure the carbon footprint of vod platforms and a pilot sct vod certification b designs and develops business clinics providing advice on how vod platforms can best green their business models c develops a streamscapes dashboard making public data such as the carbon footprints of vod platforms available to policymakers professionals and citizens d identifies underutilised approaches that can be used by vod platforms to boost the sct e delivers a firstaid kit handbook to empower vod professionals audiovisual and cultural workers and citizens to support the sct in a bottomup manner paying particular attention to engaging young people and children in practices and blue skies imaginations towards innovation
genetic engineering as an approach to enhance the lipidbinding properties of the flowering locus t the member of the phosphatidylethanolaminebinding protein family

eu mission for adaptation to climate change perceives the improved dryland agriculture as one of the ways to adapt and survive humans have the technology and processes to address the major agricultural issues today such as pest infestation droughts the misuse of herbicides however the global warming requires a new set of tools and the willingness to adapt from all of us the key developmental switch for the flowerfruit bearing plants is the change from vegetative to reproductive growth and the timing is crucial the climate changes have been already impacting the flowering as several perennial and annual crops have flowered earlier by about 2 days per decade during the last 50 years the flowering locus t is a plant protein highly recognized as a part of the florigen complex a mobile protein that is produced in the leaf companion cells and transported to the plant shoot apex to induce flowering my previous work was focused on the ft preference to bind to phosphatidylglycerol pg over other lipid species in the temperaturedependent manner and the impact on the flowering time the msca project will address the relevance of the wider array of ftpg interactions by utilizing the genetic modifications to produce and characterize the ft mutant proteins with enhanced lipidbinding properties the super sticky ft would be difficult to remove from the membrane which could have a potential industrial application a challenge would be to create the protein that could not bind to the membrane which will shed a new light onto flowering regulation the multidisciplinary approach consisting of molecular biology biochemistry structural chemistry and biophysics will produce deliverables for the subsequent in planta project the measured impact of different ambient temperatures will provide us with the knowledge of the finetuning and control over the proteinlipid interactions which could have the longstanding effects in the agricultural applications
mechanism and targeting of topoisomerase regulatory interactions to arrest mycdriven tumors

inhibitors of dna topoisomerases tops top1 top2 are mainstays of anticancer therapy while they have proven effective the toxicity of current top drugs caused by dna damageinduced apoptosis of noncancer cells limits their use in clinic development of tumourspecific top inhibitors will require a better knowledge of the mechanisms of tops this research program aims to define how top are regulated during transcription and replication and develop drugs that target these regulatory mechanisms for anticancer treatmenttops promote transcription and replication by removing dna supercoiling generated during polymerase elongation in my works published in cell and molecular cell i have discovered that the activity of tops in the cell is regulated the oncoprotein myc joins top1 and top2 in a topoisome complex and stimulates their activities to remove the supercoiling produced during transcription and replication thus boosting cellular proliferation therefore i propose that targeting the mechanism of the topoisome instead of the single tops will selectively halt myc oncogenic function while preserving physiological top activity avoiding the generation of dna damage associated to current top drugs by using new genomic tools to analyse dna topology advanced biochemical and microscopy approaches as well as drug screens i will define the mechanism of mycdriven transcriptionalreplicational acceleration via topoisome assembly and develop drugs blocking topoisome activity to arrest tumour growth i predict this proposal is feasible based on my excellent background compelling preliminary data and strong collaborations with scientists at ki and national institutes of health the work will identify novel strategies to target tops that can be put forward in clinical trials for the benefit of society this new way of targeting tops to affect myc activity constitutes a beyond the stateoftheart and groundbreaking approach to the field of cancer biology
sustainable reactor and microreactor designs for boosting green and digital innovation

reactor technologies are core to many chemical and biological processes therefore enablers of defossilisation digital empowering and economic growth eg new reactor designs are required for manufacturing of chemicals from solar light and advanced microreactor designs are key to meet needs in personalised medicine the design of reactors and microreactors share fundamental concepts such as mass and heat transfer and reaction kinetics often referred to as first principles the university of minho uminho has built international reputation for innovative fundamental research in biomolecular and cellular processes with multiple researchers ranked in the top 1 of most cited by accessing a range of worldclass analytical microfabrication and supercomputing facilities and deploying machine learning and computational modelling driven by experimental big data sets reactors50 will demonstrate and deliver a number of new sustainable reactor and microreactor concepts in full respect of first principles these technologies will be disseminated and exploited to enable innovative green and digital devices and processes and foster economic growth directly contributing to sustainable development goals and setting eu as a global leader in the development of green and digital reactormicroreactor based innovations the era chair will bring expertise in reaction engineering and an international interdisciplinary network from nonwidening countries to nurture at uminho a transformative research training and technology innovation programme that will boost excellence and attract and mobilise outstanding talents this will advance uminhos longterm ambition of establishing a worldclass centre of excellence and innovations based on moleculartocellulartoreactor nexus driving the development and implementation of transformative tools and devices able to generate global impact in three key areas of intervention of the institution food environment and health
boltzmann models for polyatomic gases and mixtures analysis macroscopic limits and entropy methods

bame is a project in applied mathematics tackling problems in kinetic theory of gases we will focus on the system of boltzmannlike equations that describes gas mixtures composed of monatomic and polyatomic gases experience has shown that kinetic models accurately describe strong nonequilibrium processes in gas flows however most of the mathematical theory is limited to the oversimplified case of a single monatomic gas our aim is to contribute in filling this gap between study of more intrigant gases suitable for applications and the current state of the art in mathematical theory of kinetic equations objectives are to study regularizing effects of the boltzmann operator integrability smoothness and strict positivity of solutions with the ultimate goal of encoding large time behavior using entropy methods the project will bring together the researcher with distinguished expertise in modelling and analysis of polyatomic gases and mixtures at the mesoscopic level and the host with groundbreaking work on entropy methods for macroscopic systems the two levels of descriptions will be bridged formally through hydrodynamic limits at the secondment leading to the redesign of entropy production program to the system of interest the fellowship will enable the researcher to gain new analytical skills and greatly improve transferable skills through the reach training offer at the host university of graz moreover it will significantly extend her research network and facilitate participation in leading events in the field leading to the capability to launch her own research group in the future and to enhance the career perspectives in academia
multidimensional representation enabling an alternative research agenda on the citizenpolitician relationship

political representation the relationship between politicians and citizens is at the core of democracys legitimacy and functioning most empirical research in political science studies two aspects of representation 1 whether politicians substantive policy preferences match those of the citizenry or 2 whether representatives are like their constituents in terms of descriptive characteristics eg gender or race however recent research in political theory has highlighted additional dimensions of the citizenpolitician relationship eg whether citizens identify with politicians they have not voted for how politicians relate to their party and argued that citizens own views of how they want to be represented should be the starting point for studying representation yet these insight have barely affected how representation is studied in quantitative political science suggesting that we may currently neglect important aspects of representation multirep aims to ascertain whether citizens care about further dimensions of representation and develop the methodological tools to study them thereby fundamentally reshaping the scope and depth of empirical research in the field first it uses indepth citizen interviews and surveyexperimental techniques to determine how people think about representation and which dimensions are most important to them second for the most important dimensions it develops novel quantitative survey and textanalytical tools to measure citizens preferences and politicians behavior third it advances and operationalizes normative standards to assess the quality of representation on these dimensions on the basis of empirical data thereby multirep will enable an alternative research agenda on the citizenpolitician relationship that takes a broader perspective given citizens declining trust in democratic politics we cannot afford to maintain an incomplete picture of what it means for citizens to feel represented
hybrid electric regional aircraft distribution technologies

aviation needs to meet the ambitious targets of the european green deal this means a step change is needed towards hybrid electric regional aircraft to significantly reduce the fuel burn this can only be accomplished with power distribution networks that can safely handle the high power and high voltage levels ultimately up to several megawatt the hecate project will address the associated challenges of system weight and power density high voltage challenges with lightning arcing and electromagnetic interference as well as optimized thermal management in addition to digitizing the design process with digital twins this will lead to transformative technology bricks which are holistically optimized at system integration architecture level the hecate project will demonstrate a 500 kw architecture in a copper bird at trl5 this will provide a clearer understanding of high voltage challenges and how to mitigate them with a scalability roadmap towards caju phase 2 flight demonstration and exploitation in a 2035 new built hybrid electric regional aircraft also environmental impact and lca will be assessed for optimal alignment and ensuring certifiability hecate will establish relationships with other clean aviation projects eg her01 for mw propulsion her02 for thermal tra01 for architecture tra02 for certification and authorities and standards groups eg easa eurocae as a set of key enabling technologies that are well integrated hecate will contribute to the clean aviation sria and its expected impacts and fully fulfill the calls expected outcomes the 37member consortium mobilizes key eu based industries throughout the entire existing supply chain from aircraft oems to system integrators to system and subsystems suppliers 5 of which are smes 17 rtos complement and reinforce the industries which also ensures knowledge gained is embedded in future research and education programs hecate requests 34 210 348 of grant
deciphering the roles of reactive oxygen species and calcium during viral infection in arabidopsis

as sessile organisms plants always have to deal with different environmental stimuli the generation of reactive oxygen species ros and calcium flux as second messengers are one of the common strategies to respond to such stimuli upon perception of pathogens molecular warning signals ros and calcium propagate celltocell to trigger defence mechanisms however the precise roles of ros and calcium during viral infection process and the associated signalling mechanism remain largely unknown viruses are obligate intracellular pathogens that hijack host machineries to facilitate their replication and propagation across the plant through plasmodesmata communication channels bridging the plant cells the virosca projects goal is to explore the mutual role of generated ros and calcium signals and to study the crosstalk between the two signals during viral infection and later identify the virus elements that specifically induces such signals i will integrate arabidopsis genetics biosensors genome editing technology crisprcas9 and advanced microscopy techniques to decipher the roles of plasma membrane pmlocated ros and calcium related candidate proteins and pm organisation nanodomains during the plant virus infection process the novelty of the project is the use of a powerful pathosystem and biosensors to study the crosstalk between ros and calcium signalling
beyond the chromosome unravelling the interplay between interchromosomal genome architecture and mrna biogenesis

in trans3 we will develop the theoretical and experimental framework to understand interchromosomal genome structure and activity despite advances in sequencing chromosomes and mapping their three dimensional 3d organization a full picture of 3d genome structure that details how the borders of various chromosome territories functionally interface one another is still missing as an analogy our world map does not indicate most natural corridors or manmade infrastructure that connect countries to one another worse we barely understand how such connections function my recent work has identified one of the few functional interchromosomal trans dna interactions known to date a splicing factory involving over ten chromosomes and orchestrated by the musclespecific protein rbm20 around its key target the ttn premrna i hypothesize that this exemplifies how mrna biogenesis instructs the formation of transinteracting chromatin domains tids around mrna factories nuclear compartments that facilitate gene regulation we will test this general hypothesis by dissecting the mechanisms and function of a specific diseaserelevant model the rbm20 mrna splicing factory we will then explore the global impact of these regulations first wp1 we will mechanistically assess how mrna factories form and act through live imaging of the nuclear positioning and alternative splicing dynamics of an rbm20regulated locus secondly wp2 we will examine the physiological role of mrna factories by studying the effects of diseaseassociated mutations in rbm20 and the ttn regulator gata4 and of genetic variability in ttn regulatory regions finally wp3 we will develop and deploy a novel pipeline to identify validate and study new tids and mrna factories through the combination of molecular biology bioinformatics biochemistry and single cell biology in all trans3 will venture beyond the chromosome frontier towards a deeper understanding of nuclear structurefunction