Dragon09/odtu_chatbot huggingface dataset:
causal pattern analysis of networked economic sovereignty

the legal concept of sovereignty does not capture foreign trade relations networks or economic clout this shortcoming has resulted from a historical reduction of its meaning since the 1600s this project will analyze legal concepts of sovereignty that developed before that time within six networked cities of commerce bruges southampton rouen lübeck toulouse and florence in the period of 14001620 cities were interconnected through trade routes correspondence and diplomacy legal concepts of sovereignty were crafted bottomup and were more encompassing than the presentday legal concept of sovereignty also for economic relations in the process these concepts absorbed changes within the cities and in the economic relations between cities in the project proposed agentbased and network methods will be used to track down these changes the dynamism of conceptual change at the level of individual cities related to commercial political and social developments which will be assessed with agentbased modelling these developments influenced institutional setups constitutional approaches the organization of trade and policies of access toward foreigners at the level of networks between cities dynamics impacting on sovereignty concepts related to foreign relations and yielded features different to developments within cities network analysis will make it possible to detect the dispersal and weight of sovereignty concepts and whether some concepts underpinned a transnational field of sovereignty causal patterns underlying change will be the outcome of this research into the cities and their networks and these patterns will be used to create an updated legal concept of economic sovereignty
implementing a new line of defence to avoid the catastrophic collapse of precast buildings

disastrous building collapses often occur due to the propagation of localinitial failures although effective for small initial failures current design approaches addressing this issue can inadvertently increase the risk of catastrophic collapse propagation after large initial failures the erc consolidator grant endure has introduced a novel fusebased segmentation design approach to overcome this alarming limitation successfully testing a fullscale precast building to validate its effectiveness while this approach can be advantageous for different types of structures its implementation in precast concrete buildings is key to maximizing its impact due to several advantages in terms of efficiency and sustainability precast structures are being increasingly used for highoccupancy and critical buildings incorporating fusebased segmentation in these structural systems would thus provide a new last line of defence against catastrophic failures in the buildings for which the consequences of such an occurrence are most severe however at this stage of development the design of a fusebased segmented precast building requires advanced computational analysis and several iterative procedures that are unfeasible for most building projects such complexity can hinder the adoption of fusebased segmentation in practice therefore truly unlocking the market penetration potential of fusebased segmentation solutions for precast buildings requires costeffective implementation tools and validation across a broader range of precast systems encast aims to bridge these gaps by simplifying design procedures developing userfriendly software performing experimental demonstrations and crafting a tailored exploitation strategy for fusebased segmentation solutions for precast buildings the projects success will lead to wider adoption of robust precast systems helping deliver more affordable and sustainable buildings that contribute to improving societal resilience
alternative gene ends the crosstalk of rna cleavage and transcription termination

the human genome contains only 20000 genes however most of them encode multiple transcripts resulting from alternative promoter usage splicing and 3 end selection gene 3 ends can be defined by the positions of rna 3 cleavage or the location where rna polymerase ii terminates transcription alternative 3 ends determine the properties of the encoded protein typically its abundance but sometimes also domain structure as for immunoglobulin m heavy chain which is membranebound or secreted depending on the 3 cleavage site widespread changes in 3 end usage are characteristic of many processes eg differentiation and cancer like neuroblastoma we do not understand what drives this selectivityin this research project i will answer the fundamental question of how the location and timing of rna polymerase ii entering into termination mode impacts on the choice of the alternative cleavage and polyadenylation site aim 1 i will use biochemical and genetic approaches to elucidate the sequence determinant of alternative cleavage and termination aim 2 and investigate sequenceindependent components of alternative termination aim 3 i recently pioneered the measurement of 3 cleavage positions together with locations of transcription termination by a novel transcriptomic method i will apply this method to investigate the timing of changes in cleavage and termination relative to each other on an averaged cell population level and use a new technique to test this for single molecules i will also determine the baseline for cleavage site selection utilizing a newly developed in vitro system combining those unique integrative and separationoffunction approaches will yield a comprehensive view of alternative gene end regulationultimately understanding the complex crosstalk between rna cleavage and transcription termination in alternative 3 end selection will enable the manipulation of this process eg to alleviate diseases such as neuroblastoma
chemical design of smart molecular2d devices for information technologies

the final goal of 2dsmarties is to develop a new generation of magnonic devices based on hybrid molecular2d heterostructures in which a precise control of the spin dynamics can be achieved by external manipulation of stimuliresponsive molecules with this aim in mind the project will establish an efficient theoretical and computational framework to guide the synthetic efforts towards the creation of low power consumption and highly tunable nanodevices for information technologies using a chemical approach the recent emergence of 2d van der waals magnetic materials provides unprecedented buildingblocks to transmit storage and process information using spin waves whose quanta are called magnons at the limit of miniaturization we will exploit the potential of switchable organic and spin crossover molecules to act as emitters modulators and detectors of magnons at interfaces formed by this class of molecules and 2d antiferromagnets this will open a versatile route based on smart molecules to face some of the current challenges in magnonics in concrete we will provide 1 a more profound understanding of the hybridization of molecular orbitals on magnetic surfaces as well as the effect of these hybridized states on the spin dynamics of 2d magnets 2 a software package to model magnon dynamics in hybrid materials 3 a deep analysis of strainmagnon coupling effects due to the thermal or lightinduced spin switching in spin crossover systems deposited on 2d materials 4 an efficient quantum transport code accounting for spinorbit torque effects to understand the enhancement of properties in the 2d material when interfaced with a topological insulator and 5 the creation of novel devices as a proof of concept we envision the birth of a new interdisciplinary field namely molecular 2d magnonics with impact in molecular nanoscience solidstate physics and materials science leading to promising longterm applications in information technologies
designing of multifunctional nanomaterials for lightdriven innovation technologies

delight aims at excellence of europe in nanoscience and impact in research and development at the highest level the project focuses on multifunctional nanomaterials based on colloidal particles organicinorganic perovskites and organic and biomaterials design and fabrication of these materials for stateoftheart applications requires a high level of interdisciplinarity with expertise from chemistry physics material science engineering nanofabrication and biology combined with the most advanced spectroscopy tools the scientific objectives of delight are to establish a platform of highly versatile functional nanomaterials with the use of machine learning and artificial intelligence for materialdevice development and characterization the focus is on multifunctional hybrids heterostructures and assemblies and to fully exploit their potential for catalysis energy lighting plasmonics and theranostics the research is organized in 3 work packages wps that target nanomaterial development functional composites and indepth characterization and device applications social and training objectives are the education of young researchers in europe on the highest level with emphasis on interdisciplinarity that is fundamental in modern nanoscience the advancement of technological knowhow that enables a sustainable and ecofriendly modern society and promotion of gender equality in the scientific landscape at all levels these goals are implemented in a wp dedicated to training organizing lectures workshops technology transfer and outreach and dissemination eventsdelight assembled an academic team of outstanding excellence which links key players in the eu working on stateoftheart nanomaterials with world leading universities in the us canada and argentina that are known for their unique scientific and technological capabilities and efficient technology transfer
nanotechnologyenabled deep profiling of the blood and brain proteome at the intersection of neurodegeneration and neurooncology

nanoneuroomics ambition is to bring together nanotechnology proteomics and blood biomarker discovery at the emerging intersection of neurodegeneration and neurooncology nanoneuroomics proposes a nanotechnologybased innovative solution for the integrative profiling of the blood and brain tissue proteomes to address two interconnected challenges i the unmet clinical need for early diagnostic and diseasemonitoring blood biomarkers for two of the most challenging central nervous system disorders namely alzheimers disease ad and glioblastoma gbm and ii the adgbm inverse comorbidity knowledge gap and intriguing molecular interrelation nanoneuroomics presents a novel approach in which nanoparticles are employed as scavenging agents to uncover brain diseasespecific protein markers in blood otherwise buried under the overwhelming signal of highly abundant molecules nanoneuroomics aims to tackle the technological challenge of discovering highly specific blood biomarkers by longitudinally tracking blood and brain proteomic signals at different stages of disease progression to leverage its full potential the proposed research programme combines longitudinal preclinical studies with human patient clinical validation studies such multidimensional proteomic approaches are expected to pioneer new blood biomarker discoveries and to provide mechanistic insight into the comorbidity of neurological diseases nanoneuroomics attempts to discover a distinct set of dysregulated proteins for each of ad and gbm independently and to unveil overlapping molecular pathways to explain the adgbm inverse comorbidity in a broader context nanoneuroomics aspires to bridge the gap between brain pathophysiology and molecular alterations in the blood across the biological continuum of disease progression the project takes on a multidisciplinary approach and builds on breakthroughs in nanotechnology and omics sciences to advance early detection and stratified medicine
imaging the topological defects of lightinduced phases in quantum materials

quantum materials host many exotic and useful phases and harnessing these states has spurred tremendous research effort however the full potential of quantum materials lies in the rich landscape of higherenergy hidden phases those which are not thermally accessible ultrafast laser excitation has recently emerged as a way access these hidden phases leading to the idea of rewriting material properties on demand but these states usually only survive for hundreds of picoseconds thus a key outstanding question remains how can we stabilize lightinduced phases one key mechanism which can stabilize a phase is topology the ultrafast phase transitions induced by femtosecond laser pulses naturally lead to the generation of topological defects these defects which can only relax after propagating until they encounter another topological defect could either offer a route to stabilizing lightinduced phases or impede their formation and have been invoked in both contexts to explain many observations however actually imaging these nanometer scale defects on the femtosecond to nanosecond timescales required for lightinduced phases has not been possible and so the role of topological defects in lightinduced phases remains unclearin knotseen i will perform the first real space imaging of topological defects in lightinduced phases using coherent xuv imaging methods which provide the necessary spatial temporal and spectral resolution to map topological defects at the nanoscale and out of equilibrium i will map the creation propagation and destruction of topological defects in two important cases quenched superconductivity in the cuprates and lightinduced phases in the manganites a novel data analysis approach will be used to distinguish repeatable from stochastic dynamics at the nanoscale knotseen will reveal the mechanisms by which topological defects control lightinduced phases enabling new tools to stabilize and selectively control them
maximising felement oxidation states

the applicant is a rising earlycareer scientist with an international reputation in frontier rare earth and actinide science this stg project melds synthesis and electrochemistry with computational and spectroscopic methods to afford a transformative advancement in electronic structure and oxidation state control in felements by advancing our understanding of the design principles which influence the properties of these complexes we propose to maximise their stability and expand beyond the current approaches to isolate molecular lanthanide species in unprecedented high oxidation stateswe target high oxidation state lanthanide ln actinide an and transuranium felement complexes beyond the current stateoftheart by expanding to novel ligand platforms which address all key aspects to maximize the thermodynamic and hence electrochemical stability of these powerful oxidisers we will show that the range limit of tetravalent ln ions available to solution chemistry has not been reachedby accessing high oxidation states we will isolate multiply bonded motifs to lniv beyond ce for the first time including iconic organometallic linkages which offer unique spectroscopic epr and nmr handles with which to probe the bonding in these systems this will be extended to actinide and transuranium elements affording unprecedented opportunities to gain insight into orbital energy vs spatial overlap components in bonding and probe the relative magnitudes of interelectronic repulsion spinorbit coupling and crystal field effects in felementsan stg will provide resources required to bring this ambitious project to fruition we will address the rarity of high oxidation state 4felements and define the chemical properties that can be leveraged to control their electronic structures this addresses the quantum flagship a key horizon 2020 priority area and will train a cohort of interdisciplinary scientists essential for the scientific goals of the eu
ocean night helping society understand the importance of the marine ecosystem

life started in the oceans oceans cover the majority of earths surface and are the single largest ecosystem on the planet billions of humans live in coastal areas and depend on the functioning of this ecosystem to live unfortunately human activities are seriously endangering the health of the marine ecosystem it is therefore critical to raise awareness of the richness of this ecosystem its importance the challenges it faces and what we as citizens of the world can do to improve and preserve it through our personal choices with the mcsa researchers night proposal ocean night we aim to contribute to this challenge by raising marine science literacy across the general population and promoting the appreciation of the importance of the marine ecosystem our proposal brings together all public research institutes across spain working on marine science for a comprehensive 2years outreach program we will leverage the substantial outreach experience of the institutes to deliver a diverse and coherent program of events aimed at engaging a geographically wide and socially diverse set of regions within spain
innovative minimally invasive device to support the natural movement of the heart in heart failure patients

syntach cs is a groundbreaking lifesaving device for longterm cardiac support that restores the natural function of the hearts mitral plane movement in patients suffering from left ventricular heart failure the technology is based on recent findings of the physiological movement of the intact heart which pumps with a scooping longitudinal movement of the mitral valve in heart failure this movement is impaired and the heart is unable to pump enough blood to meet the metabolic needs of the body syntach cs works in synchronization with the heart supports the cardiac movements and reestablishes a natural healthy movement it is fully implantable in a minimally invasive procedure heart movement support is enabled thanks to a mitral anchor ring connected to a drive unit implanted in the lower apex region of the heart from which a pulsatile movement is transferred to the mitral plane the system is recharged and monitored wirelessly with no elements protruding through the skin
symbiotic interactions at the origin of eukaryotes

recent advances in environmental microbiology metagenomics and phylogenomics strongly suggest that the eukaryotic cell evolved from symbiotic consortia involving an asgard archaeon and at least the alphaproteobacterial ancestor of the mitochondrion however many genes of prokaryotic origin in the last eukaryotic common ancestor leca appear to originate neither from archaea nor alphaproteobacteria suggesting that other bacteria eg deltaproteobacteria may have contributed to eukaryogenesis as additional symbionts or gene donors to ascertain the origin of these genes it is essential to better understand the ecology of symbiotic microbial consortia involving asgard archaea aa and in particular to identify the partners with which they interact in natural ecosystems in this project i will combine metagenomics phylogenomics fluorescenceactivated singlecellconsortium sorting highthroughput microfluidics stateoftheart fluorescence and electron microscopy techniques and cultivation approaches to identify and characterize members of aa syntrophic consortia and their associated viruses in a broad variety of microbial mats and oxygenpoor environments with this information i aim to i identify the partners of aa syntrophic consortia across ecosystems determine whether they coevolve and unravel their ecological preferences ii characterize the metabolic interactions and phenotypic properties of aa symbiotic consortia in culture andor from sorted consortia populations iii characterize the cell ultrastructure and potential presence of endomembranes in members of aa consortia their threedimensional organization and their spatial distribution in microbial mats and iv identify potential bacterial symbiotic partners involved in eukaryogenesis in addition to the mitochondrial alphaproteobacterial ancestor andor gene donors to the leca or its asgard archaeal ancestor our results should substantially advance understanding of eukaryogenesis
young international academics postdoctoral programme

the young international academics postdoctoral programme yia is a career development program proposed by the university of luxembourg unilu to nurture earlycareer postdoctoral applicants to gain momentum in interdisciplinaryintersectoral research yia applicants are international talents willing to propose and realize their own interdisciplinary research projects through a bottomsup approach yia will welcome in two calls a total of 10 postdoctoral fellows with 36month contracts over 5 years yia is open to all disciplines and sectors involving unilu in the drive towards an increased interdisciplinarity and intersectorality which are strategic for unilu for the country and for europe a unique aspect of yia is its integration into unilus institute for advanced studiesluxembourg ias created in 2019 to promote interdisciplinarity and outreach towards the society this integration provides the yia fellows with 1 a supervision for interdisciplinary and intersectoral research with more than 350 potential cosupervisors and with about 350 potential publicprivate partners 2 peer and crossgenerational interactionsmentoring through the ias fellows invited distinguished senior scientists early career researchers and a mandatory academic or industrial secondment and 3 a truly international flavour in an environment that cherishes diversity and excellence yia fellows recruited at unilu are offered competitive contracts with mobility fellowships and access to excellent research infrastructures a professor of unilu provides supervision for the primary discipline of the applicants project and a cosupervisor covers the complementary disciplinesector the yia fellows are offered an la carte training including mandatory courses to suits the fellows career aspirations increase the fellows interdisciplinarity and employability the yia programme will support a rapid ramp into a longterm unilu funding of postdoctoral ias fellows
horizon europe office in ukraine as the key national contact point ncp

the agreement with ukraine associating it to horizon europe and euratom rt programmes has been in force since 9 june 2022 and represents a key instrument to support ukrainian researchers and innovators in the context of ongoing military aggression by russia ukrainian entities can participate in the programmes on equal terms with entities from eu member states ukraine does not have to contribute financially for years 2021 and 2022 and there is a general encouragement across the horizon europe work programme to create opportunities where possible for the affected persons and entities of ukraine at the same time ukraines ri capacity both at institutional and individual levels is at risk in view of public ri budget cuts and destroyed research infrastructure according to the latest survey out of more than 2000 ukrainian scientists 38 have been forced to relocate internally 15 have left abroad and three quarters are struggling to carry on their workin relation to other associated countries horizon europe offices exist in georgia executive agency of the ministry and turkey the scientific and technological research council tubitak and represent useful tools to facilitate andor improve these countries in the horizon europe programme a grant to identified beneficiary is an appropriate implementation modality for this action as it will reinforce the key ri public institution of ukraine the national research foundation of ukraine nrfu in view of the ongoing military aggression by russia and its farreaching impacts on the ri sector in ukraine the nrfu is the only public institution that runs competitive rd calls in ukraine