Dragon09/odtu_chatbot huggingface dataset:
adaptive digital systems for sustainable construction and material management in the circular economy

adapt4ce is an innovative initiative aimed at revolutionizing the construction sectors approach to sustainability and resource efficiency the project focuses on sustainable deconstruction and material reuse through advanced digital technologies such as artificial intelligence machine learning augmented reality additive manufacturing am blockchain and the internet of things a primary goal of adapt4ce is to create expert systems for precise material characterization to improve traceability with rfid technology and to establish localized material banks for effective resource reuse by developing digital tools for informed deconstruction decisionmaking the project seeks to implement circular economy principles optimize the use of resources and ensure environmental sustainability in construction practices key activities include the development of computational algorithms for structural optimization integration of design for disassembly principles into building information modeling tools and the conduction of life cycle assessments for construction materials to promote sustainable design practices and reduce environmental impacts the project exploits advanced am techniques to enhance the adaptability durability and sustainability of construction materials by identifying smart materials with selfhealing properties and furthering the capabilities of 3d4d printing technologies adapt4ce aims to transform the industry standards and benchmark new manufacturing methods against traditional practices a centralized digital platform is being developed to integrate bim databases and digital tools to support the entire lifecycle management of construction projects this platform will facilitate predictive maintenance through digital twin technology ensure dynamic adaptation to changing conditions and enable stakeholder engagement with advanced data management and analysis tools
metabolomics investigation of cystic fibrosis pulmonary exacerbations

cystic fibrosis cf is a lethal genetic disease affecting 1 out of 2500 newborns in cf patients compromised innate immunity enhances the susceptibility to colonization of lower airways by different microbes leading to longterm bacterial infections data suggests that the resulting hostpathogen interactions can shape the course of disease progression but this relationship is still poorly understood i propose to use cf patients samples of exhaled breath condensate to investigate intramicrobial interactions and hostresponses especially during pulmonary exacerbations pex which are recurrent episodes of acute worsening of respiratory symptoms adversely influencing patients quality of lifemetabolomics ie the exploration of small molecules within a biological system under defined conditions has been acknowledged to be the omics discipline closest to the actual phenotype thus i plan to use an unbiased metabolomics approach based on liquid chromatographymass spectrometry to investigate the chemical environment of cf lungs with the aim of reducing interpatient variability characteristic of cf to increase the generalisability of the findings i will combine this approach with clinical information and cell biology techniques to test the immune response modulation in vitro and shed light on the important roles played by metabolites present in cf airways in the regulation of host immune responsestargeting the main hurdles in finding a cure for cf patients namely the interpatient variability and the elucidation of the immunopathogenesis of cf the expected results will give a necessary contribution to the understanding of cf mechanisms that are still largely unknown this knowledge is in turn fundamental to guide personalised clinical decisions for early intervention and amelioration of pex treatment to the best of our knowledge there are not yet studies proposing a similar methodology to achieve such an ambitious goal
the hidden weapon blockade in the era of the two world wars

the main aim of blockade is to investigate how blockades shaped the course outcome and aftermath of the world wars in both wars belligerents sought to blockade their enemies cutting them off from vital resources such as food oil information and capital to hasten their defeat existing research is contradictory and fragmentary leaving us in the dark as to the scope and the effects of blockades just as the world is confronted with new blockadesour hypothesis is that understanding the blockades is critical to the era of the world wars ca 19001960 the blockades affected societies the world over testing their resilience and vulnerability they produced new forms of violence and humanitarian care prompted innovation and learning and had integrative and disintegrative effects on wartime societies alliances and the world order the projects ambitious approach transcends the traditional fixation on western europe and integrates actors long seen as peripheral it connects the disparate histories of the first and second world wars in a single explanatory frame by uncovering the shared generational experiences and learning processes related to blockades allowing us to assess their impact on the wars and the peace that followed them the high gain promised by this project comes with the high risk that we might fail to separate the impact of blockades from other effects of warfare but it is a risk we believe we can mitigate via innovative methodology and careful source analysis blockade requires input from a range of academic disciplines economics and economic history international history cultural and war studies statistical and digital analysis and many languages only the synergy resulting from combining the four pi and the larger teams different qualifications and research methodologies will realise the potential for high scientific gains with the necessary complexity and range
linking infectious disease frontliners control efforts with central public health authorities in the african great lakes region

the african great lakes region is one of the most densely populated areas in africa and also one of the areas globally with the highest biodiversity and forced or voluntary migrations very limited information is available on the prevalence and epidemiology of infectious diseases especially gastrointestinal diseases and antimicrobial resistance that has been very understudiedlogistically it is difficult to sample and conventionally study infectious diseases in the area and such studies have limited realtime value locally in this study we will take full advantage of the potential offered by combining fielddeployable nanopore sequencing combined with metagenomics and laptop bioinformatics to establish frontline sequencing at remote sites and linking this with central sharing of analytic output newly developed bioinformatics solutions by us have made it possible to perform simple bioinformatics analyses in realtime using laptops and subsequently share the analytic output simply using the mobile net avoiding the need of transferring large amounts of data and access to highperformance computingin greatlife we will establish sequencing across six countries in the region and use this to study the abundances of amr in villages and refugee camps linking this with spatial and temporal epidemiological data will enable us to identify locally relevant drivers for amr and provide data for changing empiric treatment and policies in addition we will utilize sequencing directly on gi samples to identify the causative agents and their amr both to provide data for policies but also to provide immediate results for direct patient care in the frontline we will educate a number of people in the very frontline to utilize fieldsequencing and bioinformatics as well as more advanced bioinformaticians and epidemiologist centrally the data generated will be linked in realtime through a central hub in tanzania to public health authorities for actions
maximising impact of prescription drugs in rheumatoid arthritis

the squeeze consortium comprehensively addressed how biomarkers can be used to optimize disease modifying antirheumatic drugs dmards for rheumatoid arthritis ra ra is a chronic immunemediated disease with enormous healthrelated quality of life and socioeconomic impact a broad choice of dmards with different targets is up to date available in clinical care however without sufficient markers indicating the best choice for a particular patient treatment strategies can be ineffective cumbersome and expensive the team of leading academic centres with a firstclass record in translational and clinical research together with patients and small and medium sized enterprises smes has set out to deliver a collaborative programme to advance the clinical application of biomarkers to improve benefit safety and value of approved dmards squeeze utilizes models from data science clinical trials translational science and behavioural science to engage in a complementary synergistic and nonoverlapping manner addressing the use of biomarkers to improve the ability to select the dmard with the highest likelihood of fitting the immunophenotypic and clinical profile of the patient to optimise dose and route of existing dmards and to inform an innovative model of care focusing on patients preferences and needs to increase adherence to prescribed drugs through nine dedicated work packages squeeze integrates to validate clinical laboratory molecular digital and behavioural biomarkers to enable the recognition of patients with high likelihood of response to treatment and the selection of the drug with highest chance of benefit for an individual patient and as such improve efficacy and safety of existing therapies by squeezing the most out of existing drugs in synergy with other euwide activities
lh2 storage and fuelsystem below deck integrated in a service operating vessel

to achieve the ambitious objectives set at the international level the transition to an alternate low carbon energy source will become essential since batteries are limited to smaller ship and syntheticfuel will remain hardly available hydrogen will irremediably appear as the best alternative energy however the related challenge is to store efficiently and safely hydrogen and here liquid hydrogen lh2 is the most attractive solution alternate storage solutions ch2 ammonia have lower powertovolume ratio and additional constraints such as highpressure toxicity reverse transformation etc moreover lh2 is already becoming a standard in space aeronautics motorsport trucks navhys aims at providing a concept based on a lh2 storage and fuelsystem below deck integrated in a service operating vessel to provide to wind energy providers a fully decarbonized solution the design of the lh2 system its integration in the ship and the risk analysis will be very challenging as they deviate from previous prescriptive safety rules and design guidelinesnavhys will design a fuelsystem to supply gh2 at 5 bartambiant to be used in any propulsion system to produce from 500kw to 2mw this system will integrate a lh2 pump benefiting from arianegroups experience in ariane 6 thus making it more robust to sloshing and allowing beneficial impact of lowpressure tank considering sizing and loading limit a prototype of the distribution system will be tested on arianegroup test benchnavhys will confirm the safety and the operability of the proposed design with an approval in principle delivered by the classification company bureau veritasnavhys will address refuelling operations and supply chain evaluation based on the horizon europe delhyvehr project which already aims at demonstrating the capacity to refuel lh2 with a high flowratenavhys will also integrate an analysis of the potential scaleup of the system and a spillover towards other applications
intentdriven native ai architecture supporting computenetwork abstraction and sensing at the deep edge

the 6g smart networks of the future will provide the highperformance and energyefficient infrastructure on which next generation internet and other services can be developed and deployed 6g will foster an industry revolution and digital transformation and will accelerate the building of smart societies leading to qualityoflife improvements facilitating autonomous systems haptic communication and smart healthcare to achieve the aforementioned objectives in a sustainable way it is well understood that new approaches are needed in the way the telco infrastructures are architected federated and orchestrated these new approaches call for multistakeholder ecosystems that promote synergies among mnos and owners of all kinds or computational and networking resources that will share the extraordinary costs of yet another generation upgrade from 5g to 6g while facilitating new business models it is clear that the new architecture paradigms bring unprecedented complexity due to the sheer scale and heterogeneity of the orchestration domains involved that should be matched by equally capable automation capabilities thus 6g is aiming for the holy grail of pervasive aidriven intelligence termed as native ai however the multistakeholder infrastructures foreseen in 6g as per the network of networks concept will add a level of unprecedented management complexity due to the sheer scale and heterogeneity of the orchestration domains involved 6gintense aims to abstract and federate all kinds of computational and communication resources under an internetscale framework that is governed by an intelligent orchestration paradigm termed as dimo
investigation of biological seal whiskers to create artificial whisker sensors for underwater robots

marine animals employ diverse and fascinating flow sensing phenomena by exploiting the ambient complex fluid mechanics to track prey and escape from predators seals are known for their remarkable longdistance preyhunting capabilities owing to their whiskers which serve as ultrasensitive flow sensors for eg a seal is able to detect a fish swimming 180m away by following its vortex streets while the unprecedented tracking abilities of seals and the role played by seal whiskers in reducing vortexinduced vibrations have been conclusively demonstrated in past the fundamental mechanisms behind such pinpoint tracking remain unclear the geometrically intricate shape of the seals whiskers is believed to maximize their signaltonoise ratio to generate high sensitivity to the tiniest hydrodynamic trails in this project we propose investigations of the seal whisker behaviour both in live seals and in controlled lab experiments to shed new light on the fundamental mechanisms that enable the seal to display its excellent preytracking behaviour in particular how the seal effectively utilizes the spatial distribution of the whisker array on its muzzle to conduct multipoint flow measurements to track and locate its prey is unknown and of great significance we propose to study the morphological mechanical and material properties of whiskers to explain the exquisite sensing capabilities of seals and further use this understanding to develop biomimetic flow sensors for underwater robot navigation miniaturized and selfpowered micronano electromechanical systems memsnems strain and flow sensors will be developed for experimental animal studies and to develop artificial 3d printed mems whisker sensors and muzzles for experimental fluidstructure interaction studies an artificial seal muzzle with mechanosensory mems whiskers will be applied on underwater robots to create artificial vision and energyefficient maneuvering through fishlike schooling
quantitative multimodal pulseandlabel timeresolved chromatin maps

chromatin packages the eukaryotic genome in a highly dynamic fashion with dramatic structural changes during every cell cycle at the same time chromatin provides remarkable stability for transcriptional regulation and genome organization for example in maintaining gene expression programs and lineage identity during complex organismal development a mechanism to propagate information through disruptive transitions in the cell cycle namely dna replication and mitosis is key in maintaining heritable socalled epigenetic chromatin statesproteins that build and interact with chromatin foremost histones are much more than static architectural components this motivates the development of timeresolved quantitative assays in the living cell which will allow to capture dynamic features of chromatin states over timescales from minutes to days building on a synthetic biology toolbox a quantitative multimodal pulseandlabel strategy will be developed following protein populations in both time and subcellulargenomic space dynamic proteinprotein interaction networks and chromatin maps will be capturedthe project will use to stateoftheart quantitative biochemical imaging genomics and proteomics readouts including singlecell readouts these will feed into mathematical models to describe the dynamics and potential heterogeneitystochasticity of the system under study predict its response to perturbations and guide mechanistic hypotheses the project will systematically decipher mechanisms for propagating epigenetic chromatin states starting with the fundamental rules of histone inheritance through replication and mitosis additional levels of complexity introduced through chromatin remodeling activities nucleosome turnover and histone exchange will be integrated finally the dynamics underlying developmental chromatin state transitions including asymmetric cell fate decisions will be resolved
evolutionary government origins and consequences of structural change in government

why do government structures change traditionally the answer refers to political parties exercising control over a state bureaucracy yet government structures have been changing ever since they emerged alongside the modern state and thus already before parties existed the recent decline of party government worldwide also begs the question whether other actors and mechanisms matter that have been underestimated so far meanwhile it became a truism that structure shapes policy but existing research focuses on other effects of structural change in government such as democratic and economic outcomes or cabinet governance we lack systematic analyses of how structural change affects government policyto address these gaps statedna studies the change of units inside ministries and agencies as the building blocks of the modern state it submits a novel theory of evolutionary government that regards structural change in government as an interplay between a units structural features and its organizational and environmental environment this notion of multiple levels allows to study more than partycentric causes of change and for the first time to analyze the effects on government policy explicitly as evolutionary consequences managed by distinct unitsstatedna breaks new ground by applying genetic measures to assess structural change in government establishing the most comprehensive data set which begins with the primordial soup of the early 19th century when government structures fragmented 150000 units six countries 18152025 for the empirical analyses existing historical data on legislative activity organizational and environmental features will be used and extended statedna will exploit methodological advancements in biology such as data assimilation techniques to analyze the origins and consequences of structural change in government and to forecast such change thereby injecting a predictive notion into government studies
lipid droplets and phytovirus infection

the rapt lipid droplets and phytovirus infection project undertakes an innovative exploration into the potential role of plant leaf lipid droplets lds in the replication of plant viruses specifically focusing on plant rna viruses lipid droplets which are ubiquitous organelles derived from endoplasmic reticulum er membranes play key roles in energy production membrane biogenesis and stress signalling while certain animal rna viruses utilize lds for energy or as platforms for viral replication compartments vrcs evidence for similar mechanisms in plant rna viruses remains elusive the project builds on the previous observations made by the host lab which suggest a higher abundance of lds in turnip mosaic virus tumv potyvirus infected leaves and their spatial proximity to vrcs the hypothesis is that certain plant viruses like tumv utilize lds as energy reservoirs for their genome replication potentially facilitating direct interaction with vrcs to validate and expand upon this hypothesis the rapt project is defined into three primary objectives1 exploring the impact of plant virus infection on ld distribution and lipid metabolism2 functional validation of the involvement of plant lds in the potyvirus infection cycle3 elucidating the molecular mechanisms governing the interactions between lds and tumvthese objectives address key knowledge gaps regarding the role of lds in plant virus infection and will focus on potyviruses mainly tumv but other ssrna virus species of agroeconomic importance such as luteoviruses and poleroviruses will also be studied with the aim to expand the findings to crops the results of this project will contribute to the development of broadspectrum genetic resistances that can be harnessed by breeders to mitigate the adverse impacts of plant viral diseases on agricultural productivity
versatile furanbased polymers for strict and high value applications in packaging automotive and underwater environments

he goal of the furious project is to develop novel versatile polymers based on 25fdca to enrich the portfolio of biobased innovative monomaterial solutions proposed to replace traditional plastics the materials will be properly designed from the chemical point of view to satisfy a set of target properties required for three stringent applications where other bioplastics do not address all the requirements or traditional plastics are still widely employed biomedical and electronic packaging where resistance to sterilization and high barrier properties are necessary automotive sector where resistance to uv weathering and intrinsic antibacterial properties are the key feature and underwater devices where photoreactivity and biodegradability in seawater are requested to target such a goal all the wellestablished synthetic strategies will be used with particular attention to the exploitation of green processes to low lifecycle environmental impact polymers and to the minimization of their production cost furious material versatility will be also assessed with respect to their processability which is a further mandatory feature to be checked for real entry on the market both wellestablished technologies such as injection molding and extrusion and more innovative ones such as electrospinning 3d printing and stereolithography will be validated last but not least intrinsic recyclability will be imparted to the new furanbased polymers for both greener and mechanical recycling and for novel enzymatic recycling strategies in the case of packaging compostability will also be evaluated while underwater sensor biodegradability in marine environment will be checked being one of the key requested polymer feature innovative results of furious will contribute to the development of sustainabilitybydesign database used to assess and predict the performance of novel materials and to derive a set of guidelines for the enduse applications