Dragon09/odtu_chatbot huggingface dataset:
next generation molecular data storage

current longterm archival media such as tape and disk have several issues the most important one being that they are short lived up to 510 years forcing data to be copied between storage media every few years in a costly process which also produces considerable electronic waste longerlasting media are desperately needed and dna oligos have been identified as a major contender to be the next archival storage medium with it data is written using dna synthesis and read using dna sequencing dna is particularly promising as a storage medium due to its durability as it can last for several hundreds of years however storing data in dna oligos is currently too expensive due to the exorbitant cost of dna synthesis 012usd to write one bit as well as issues such as speed in writing synthesis and reading sequencing for this reason we propose to investigate storing data in dna nanostructures our approach is based on producing dna nanostructures like a breadboard and attaching streptavidin at a given set of locations to either write a one if streptavidin is present or a zero otherwise the major benefit of our approach is that all possible nanostructures can be built out of a predefined small set of dna oligos which can be produced cheaply and enmasse writing is therefore substantially cheaper with our approach writing reading based on atomic force microscopy and editing are also substantially faster editing information is currently infeasible with dna storage based on oligos we have successfully demonstrated the feasibility of both writing and reading in proofofconcept experiments giving confidence in the approach the goal of this proposal is to scale up the basic but successfully tested idea to make this a feasible approach at a larger scale the team proposing this work is ideally placed to make the research a success the team brings all the necessary expertise together
msabased circular hydrometallurgy for sustainable costeffective production of nmc cathode materials

on 16 march 2023 the ec published the critical raw materials act crma proposal that sets benchmarks along the strategic raw materials value chain and for the diversification of the eu supplies by targeting the domestic refining of three strategic batteryrelated crms ie ni co and mn the cicero project addresses the second crma benchmark ie 40 domestic processingrefining to tackle the twin problems of 1 europes dependence on a few third countries ie drc indonesia china for the supply of ni co and mn for our nmc liion battery production and 2 the fact that these metals are currently produced at a huge cost in terms of environment health and safety cicero puts in place a sustainable costeffective refining model for ni co and mn and the downstream conversion into madeineurope nmc cathodes the cicero project is the first ever to develop a circular hydrometallurgical ni co mn processingrefining scheme that uses methanesulphonic acid msa a commercial green reachcompliant affordable acid rather than h2so4 cicero recovers refines and converts ni co and mn from domestically available secondary raw materials a postmining raw materials sulphide laterite tailings and b nicomnbearing intermediates incl msp feni nimatte and mnanode sludge to achieve this cicero develops a suite of novel metallurgical unit processes for advanced msa leaching and solution purification the conversion to batterygrade msa salts and the synthesis of nmc cathodes in msa media with sound reagent regeneration iron recovery in line with the twelve principles of circular hydrometallurgy this research is supported by advanced thermodynamic kinetic modelling for solidliquid liquidliquid equilibria relevant for nicomn processingrefining in msa media cicero introduces a new paradigm for metallurgical processingrefining and increases societys acceptance of and trust in sustainable crm production in europe
road to friday of science flows

the refocus flow road to friday of science flows project aims at broadening citizens awareness of why ri are important to community by bringing the researchers into the focus of the general public following the trends and guidelines of both the eu and unesco all activities of refocus flow will highlight the eu green deal and eu missions as the most urgent challenges the modern humans are faced with following clear and timebound goals to offer solutions for these important issues special attention will be paid on raising the awareness that citizens must take the initiative to achieve the goals set the refocus flow having the central theme the flow of science will consist of two parts european researchers night and researchers at schools activities with the 2024s theme the flow of knowledge will focus on defining the problems facing our planet and society familiarizing citizens with the eu missions raising their awareness that only together researchers citizens industry local and regional authorities with the aid of knowledge flows should work towards successfully fulfilling the eu missions european researchers night and researchers at schools 2025s activities with the theme the flow of people will offer citizens concrete solutions to achieve challenging but achievable goals by showcasing successful results and ongoing progress of existing eu missions and highlighting the eus selfless commitment to shaping sustainable and prosperous future activities are planned to be carried out from the capital and larger cities to smaller towns and rural areas of serbiawe will reach out to the general public with special attention to pupils students families and especially those who do not have easy access ri through popular formats in public places we will show citizens that ri are designed for all and together we can create the europe with climate neutral cities and retain clean water healthy soil and food for current and future generations
paramagnetic materials studied by ultrafast ssnmr spectroscopy

paramagnetic materials have found application in various different industries in particular involving the conversion the transport and the storage of energy the characteristic microscopic feature for the majority of these materials are unpaired electrons that are located at transition metal ions such paramagnetic centers are the key element for the macroscopic properties eg reactivity to understand the function of paramagnetic materials why they deliver or fail to deliver the required properties and eventually to tune their performance the local atomic structure of the paramagnetic centers must be fully understood in diamagnetic materials these structural features typically escape xray diffraction xrd and electron microscopy em but are readily accessible to solidstate nuclear magnetic resonance ssnmr however the current repertoire of ssnmr methods is not tailored to paramagnetic systems where metal centers produce large perturbations in the spectrum of the surrounding nuclei and hamper the critical steps of the acquisition of the nmr experiments and the subsequent spectral assignment and interpretation in this project we will align modern multidimensional ssnmr experiments with ultrafast magicangle spinning mas this includes complex radiofrequency irradiation schemes using amplitude and phase modulation leveraging the unique instrumentation available at the host lab allowing us to rotate the studied sample at 110000 times per second or possibly faster supported by numerical spindensitymatrix analysis we will develop a new toolbox of ssnmr methodologies to acquire highresolution spectra of paramagnetic materials and thus precisely determining elementspecific nmr parameters linking these spectroscopical features to the structure elements from known samples will finally allow us to present the comprehensive characterization of paramagnetic electrode materials inaccessible by ssnmr to date
renewable energybased positive homes

buildings are responsible for around 40 of energy consumption and 36 of co2 emissions in the eu and 84 of their demand is still generated by fossil fuels with the green deal the eu signed its commitment to become the first continent to achieve climate neutrality by 2050 given the high relevance of the building sector for emissions reduction the concept of pebs is gaining increasing attention besides construction and demolition waste accounts for 35 of eu waste renhomes tackle the sustainable transition not only by reducing carbon emissions but also resource scarcity energy poverty and focusing on educationparticipation of stakeholdersrenhomes i develops a set of 23 solution 9 hardware industrialized panel with recycled materials prefabricated bipv insulated façade wireless iot device end user platform and bms lpwan connectivity geothermal walls bipvbapv with repurposed cells h2 storage 7 software bdea intema verifyb grt tcqi rcs cbeo and 7 circular plus energy homes cpeh methodologies for au es ee ro el fr and a universal one ii tests and implements them in 4 largescale demonstrators 19843 m2 2 renovation and 2 new construction sites in au es ee and ro and iii develpes business models combining costeffective deepretrofitting demand response and energy communitiesrenhomes i provide excess energy to the grid or to neighboring buildings 195mwhyr ii develop and install building technologies from 50 recycled materials iii uses products with 60 recyclability rates iv adopt codesign for increasing awareness and satisfaction 70 residents per demo and v make use of international support to overcome legislative barrier for the streamlining of positive energy homes with a focus on resource scarcity and recyclability renhomes approach will lead 50m m2 of floor area renovated to cpeh standards corresponding to 156 mtco2eq saved and 39226 tons of recycled materials by 2050
water efficient allocation in a central asian transboundary river basin

mountainous regions in central asia are vulnerable to consequences of climate change taking appropriate decisions for allocation of water over communities the environment and key economic sectors such as agriculture and energy is increasingly challenging due to economic and population growth as well as climateinduced changes in hydrological regimes in central asias main transboundary river basinsweact proposes to establish a climate sensitive decision support system for water allocation in two subcatchments of a transboundary river basin in central asia namely the naryn and kara darya catchments of the syr darya river basin covering parts of kyrgyzstan and uzbekistanbased on an innovative water information system that captures a thorough understanding of water availability demand footprint and allocation in a glacierfed river basin weact will enable water managers to interact with an accessible and intuitive dss to alleviate water stress for communities the economy and the environment on the short and longterm weact will enable them to adapt the allocation of water resources to the known and expected effects of climate change while encouraging the improvement of policies to correctly set water tariffs reduce water footprints and increase water use efficiency in agriculture and energy sectorsthe backbone of the project is a reliable data supply chain based on realtime monitoring integrated water demand availability and use modelling approach machinelearning and data storage in a transboundary context this will be matched with an indepth understanding of water policies and priorities that face increasing pressures of climate change growing demand and water dependencyendusers of the project hydrometeorological stations integrated models dss for water allocation will be carefully mapped invited involved and trained to establish and use meaningful results from the outset of the project
bringing newborn care home an integral mhealth solution for neonatal jaundice management

neonatal jaundice nnj affects 6080 of newborns worldwide 84112 millionyear ten percent will develop severe jaundice snj which can cause permanent brain damage or even death 114000 newborns dieyear 75000 suffer severe longterm neurological impairments a fast pointofcare affordable method for nnj screening and monitoring in the first 2 weeks of life is crucial but current methods are insufficient eg visual assessment transcutaneous device blood testhealth systems face increasing pressure on their resources it is imperative to develop more sustainable models of care and empower patients and their familiespicterus is developing the first digital platform to enable nnj screening by parents and caregivers at home and a timely referral to healthcare services our recommendation tool will allow families to monitor nnj at home with their smartphones and healthcare workers to efficiently manage a greater number of families by avoiding unnecessary visits
exploring populism in texts leveraging ai for substantive and methodological advancements

this interdisciplinary project embarks on an extensive exploration of the methodologies that underlie the study of populism through textual analysis with the primary goal of enhancing our comprehension of this intricate phenomenon the surge of populism on the global stage underscores an urgent need for scholarly investigation however the nuanced and adaptable nature of populism presents challenges complicating efforts to establish a single universally accepted definition this conceptual ambiguity not only fuels ongoing debates about the core essence of populism but also permeates empirical analyses including those centered on textual investigations despite the growing body of theoretical and empirical work a noticeable gap persists in our grasp of the methodological subtleties inherent in the analysis of populism through texts these methodological intricacies encompass a spectrum of dimensions ranging from the application of conceptual frameworks to textual analyses to the adaptation of textasdata techniques capable of capturing the dynamic evolution of populism over time this groundbreaking project marks an unprecedented endeavor in conducting crossnational and longitudinal evaluations of political parties populist discourse it employs a robust methodology integrating manual coding and machine learning techniques by engaging with theoretical concepts and deploying cuttingedge ai tools to generate unique datasets capturing populism in texts this project stands poised to enrich our nuanced understanding of how populism is conveyed across diverse temporal and contextual dimensions pushing the boundaries of current knowledge in the field
schellings philosophy of nature and the environmental challenge

the contemporary environmental crisis has triggered a revival of discussions on the concept of nature among scientists philosophers policy makers and citizens questions regarding environmental practices and the overall state of nature have become a matter of central concern but what exactly is nature beyond the specific phenomena studied by specialized natural sciences such as physics chemistry or biology is there something else beyond these particular phenomena what is the relationship between these phenomena and humanity do humans have a special status in relation to nature on my account these questions are at the core of the philosophy of nature that schelling developed at the turn of the 19th century in response to the increasing instrumentalization of nature more precisely i take schellings philosophy of nature to address versions of these same questions especially as regards a the unity of nature beyond the phenomena studied by emerging scientific disciplines such as chemistry and biology and b the status of humanity in relation to this unity the overall aim of the project is to bring out the contemporary relevance of schellings philosophy of nature by investigating it as an attempt to address these challenges counteracting mystical readings of schellings project i will argue 1 that he is concerned with the elaboration of a unified account of the phenomena studied in the natural sciences 2 that his theory of selforganization aims to provide such an account 3 that he conceives of the distinction between humans and nonhuman forms of nature as a distinction of degree and 4 that this conception of nature as the manifestation of different degrees of selforganization is relevant to contemporary debates in that it forges a middle path between anthropocentric and nonanthropocentric approaches to nature
selection efficacy at intraspecific and interspecific scales insights from haplodiplontic plants

natural selection is a pillar of evssnatural selection is a pillar of evolutionary biology it tends to fix beneficial mutations and remove deleterious ones but the factors that determine selection efficacy are yet poorly understood a proposed factor is the interaction between mutations dominance and ploidy level recessivity should reduce selection efficacy in diploids but not in haploids methodological limits make this challenging to test in species with a diploiddominant life cycle yet a whole phylogenetic clade underexplored in genomics gathers all the attributes to tackle this question bryophytes their life cycle is characterized by alternating a long haploid phase gametophyte with a short diploid phase sporophyte both phases being macroscopic it is ideal for shedding light on what drives selection efficacy within and between species thus improving our understanding of adaptation and speciation1 how ploidy affects the efficacy of adaptive and purifying selections within species using comparative genomics i will empirically test i if selection is more efficient for haploidbiased genes ie expressed primarily in the gametophyte than diploidbiased genes and ii if that difference is reinforced in species with a more complex sporophyte2 how ploidy affects the efficacy of selection against hybridization between species with theoretical developments i will quantify the extent to which the length of gametophytic and sporophytic phases influences the rate of accumulation of reproductive barriers against interspecies introgression these predictions will be confronted with genomic estimates by developing a statistical inference method3 how efficient is selection in nonrecombining genomes i will take advantage of the bryophytes uv sexual system to assess the extent to which selection efficacy is reduced on their sex chromosomes i will also tackle an overlooked issue are uv sex chromosomes efficient barriers to introgression
wetland restoration for the future

wetlands cover 58 of the worlds land area and have a huge capacity to sequester carbon c healthy wetlands accumulate c effectively due to waterlogged conditions promoting highly stable c content the eu aims to cut ghg emissions by at least 55 by 2030this ambition requires new ghg mitigation measures within all sectors including lulucf sector where wetlands as c rich ecosystem can contribute to efficiently to both eus climate targets and biodiversity strategy currently there is still a high uncertainty prevails of wetlands spatial and c sink extent as well as source estimates and sustainable alternatives in restoration this hinders the efficient use of wetlands in c mitigation and adaptation in the context of other lulucf mitigation options we will advance the stateoftheart on the geospatial knowledge base on wetlands and their use and degradation in europe we will apply a cocreation approach to develop procedural knowledge and find ways for integrating multiple targets supporting more inclusive communitybased approaches to wetland restoration diverse novel experimental data on ecosystems responses to wetlands management and restoration regimes under different types of landuse and will be acquired and synthesised on biodiversity and other ecosystem services bes at the local level living labs ll support and integrate interdisciplinary and multiactor research on ecological environmental economic and social issues models will be utilised to scale up experimental data from lls to gain an understanding of the potential impacts of upscaled wetland restoration options on bes provision as well as changes in bes provision at the eu level for various policyrelevant time periods and the most policyrelevant cc mitigation and bd targets we will assess the societal impacts of wetland restoration especially on bes benefits and costs of different restoration approaches and wellbeing impacts at local national and eu levels
deciphering the eccdna inheritance with novel plant eccdna genetic tools

enhancing plants natural innate and immune systems for the generation of primed plants that will better withstand stressors can be an effective way to reduce losses in crop production these systems are broadly defined under the plant transgenerational inheritance ti of stress memory which is based on the heritability of attained traits caused by environmental conditions i propose a new player in plant ti the extrachromosomal circular dna eccdna eccdna is recognized as a major source of genetic variation behind key adaptive traits i hypothesize that stressresponsive eccdnas in the soma of a plant can be considered as adaptive toolkits that can be transferred to the gametes during meiosis and thus to the progeny thus i have developed an ambitious but feasible plan to bridge two major gaps in this context 1 we require innovative technologies to prove causation so i will develop the first and novel genetic toolbox to study eccdnas in plants by targeted circularization driven by the novel crisprc system 2 we lack knowledge about how eccdnas are inherited so i will characterize the transmission of eccdnas from the soma to the gametophyte in arabidopsis through genomescale circleseq and cytological analysis fish circleplant offers a unique opportunity for the development of a new line of research with potentially remarkable impact because it will explore the bases for eccdnabased technologies that may be useful in crop breeding ultimately leading to the generation of stable climatesmart crops which fits with the environmental objectives of the european common agricultural policy cap of improving crop yields by applying lowinput agricultural practices
the roles of the agency of the dead in the lives of individuals in contemporary society

each from their own perspectives various disciplines have shed light on the roles fulfilled by the dead in contemporary society their findings however remain compartmentalised their insights scattered a comprehensive understanding of their role in the lives of individuals is still missing this project will benefit from the insights of each of them with the aim to transform the current partial understandings into a complex view of the roles that the dead play in individuals lives instead of focusing exclusively on the role of personally significant dead for the bereaved or treating the dead as expression of folk belief or metaphors of cultural and social problems and changes the project will view the dead as being actively involved in the intricate relationships between individuals and larger social and cultural processes the overarching aim of deagency is to generate a new theory for comprehensively understanding the roles that the dead fulfil for individuals in contemporary society this will be achieved through identifying 1 the ways individuals experience and conceptualise the agency of the dead 2 the reasons and contexts within which it is triggered and 3 the aims and manners of interaction with the dead to gain insight into the widest possible range of the roles of the agency of the dead in individuals lives the project will study them within three disparate areas of social cultural changes and problems related to the postsocialist period 1 the effects of the problematic political past mass graves 2 changing religious landscape and 3 changing social life in rural communities to access subjective experiences of individuals the ethnographic method will be used in fieldwork conducted in slovenia hungary slovakia and bosnia herzegovina through comparative analysis common patterns transcending particular changes problems and contexts will be identified leading to the final synthesis the generation of a new theory