Dragon09/odtu_chatbot huggingface dataset:
bispecific biparatopic antibodies for the treatment of cancer

immune checkpoint inhibitors have revolutionized cancer therapy yet the majority of patients do not respond to current treatments such as pd1pdl1blockade in nonsmall cell lung cancer nsclc over 70 of patients experience immune evasion mechanisms that prevent effective immune activation one such mechanism involves the overexpression of glycans on tumor cells which can modulate immune responses in this project we propose to develop novel bispecific biparatopic antibodies that simultaneously target two distinct epitopes of the target this innovative approach is designed to provide a more comprehensive blockade of immunesuppressive functions by dual engagement of the receptor our bispecific antibodies will be engineered and optimized to target different epitopes enhancing their ability to restore immune function the project will involve the engineering structural characterization and functional validation of the bispecific antibodies followed by preclinical efficacy studies in nsclc models by this approach these antibodies have the potential to overcome the limitations of existing immunotherapies offering a new therapeutic option for cancer patients who are resistant to current treatments in addition to the scientific development this erc poc project is designed to develop a robust commercialization strategy with the potential for patent filings and engagement with pharmaceutical partners our vision is to bring these bispecific antibodies to the clinic ultimately aiming to improve outcomes for patients with nsclc and other cancers
digital twinsustained 4d ecological monitoring of restoration in fishery depleted areas

to unlock and boost new discoveries that will be crucial to face climate change and regulate human actives which will be key for both environmental conservation and socioeconomical activities we aim to make all the past current and future biological and oceanographic data available to everybody therefore we will use relevant sleeping data by designing new tools and methodologies to use and process relevant data already collected for different institutions which may come from physical and chemical sensors or video cameras we will also harmonize the data promoting tools to make them the standard among researchers and datagenerator actors developing protocols and best practices like standardization tools as puck among marine sensors and monitoring platforms and unifying libraries and resources eg fanthomnet or emodnet at the same time we will ensure a secured sustained and reliable data flows by developing auto correctionvalidation methodologies and by publishing a set of tools and pipelines to ensure the trustfulness of data moreover we will be using economies of scale and enhanced standardization to conduct several pilot seabasin scale monitoring tests using two strategies 1 using existing relevant sleeping data form online and partner repositories and 2 using new data collected during field test demonstrations here we will develop tools to better support assessment studying and identifying key indicators and mechanisms to extract them from the data will generate the appropriate guidelines for policymaker researchers and socioeconomic sectors making those tools methodologies and implementations open source for the researchers and public in general will boost their utilization and improvement even after the conclusion of the present project with these demonstration examples the international collaboration and open source resources we aim to make our proposal by fact the standard gold to follow in the following years
how processions moved sound and space in the performance of urban ritual c1400c1700

processions were quintessentially performative acts that infused a sense of identity among the urban community by linking the emblematic topography of the city and creating performative spaces of enhanced ritual activity and distinctive auditory landscapes the premise of soundspace is that hermeneutic study of the procession as performance affords insight into the dynamic workings of society and the experience of urban life it aims to go beyond this to assess the impact of urban ritual on participants and earwitnesses through analysis of the social and cultural processes that lay behind that experience and of the perceptual discourses that gave it meaning and significance for all those present the procession formed a moving intersensory experience that also mobilised the emotions of the urban community but how did this work in practice in the historical past how can the historian enter into the performative moment to understand the emotional impact of sound in acoustic space the project aims to interrogate the multifaceted relationship between sound space and society by scrutinising the interstices between collective experience social expectations and memory through the prism of historical sound studies an umbrella term here used to combine a crossdisciplinary approachurban studies sensory history and history of the emotionsand dh tools virtual reality digital cartography and semantic discourse analysis it will forge a new theoretical framework by combining concepts of acoustic and emotional communities to analyse the social and cultural processes involved in the preparation performance reception and impact of the procession and the prevailing discourses that forged the significance of processional expression for the urban community the main objective is to open up new ways to explore the impact of intangible but key features of processions such as acoustic space soundscape competence density of sensory experience and emotional response
topological insulator vertical cavity laser array

vertical cavity surface emitting lasers vcsels are tiny semiconductor lasers structured as pillars of fewmicrons diameter on a chip emitting light from their surface they are now the most commonly used lasers eg in cell phones car sensors data transmission in fiber optic networks though widely used the miniscule size of vcsels sets a stringent limit on the output power it can generate for years scientists have sought to enhance the power emitted by such devices through combining many tiny vcsels and attempting to force them to act as a single coherent laser with limited success in a recent breakthrough which appeared in science magazine we presented a new scheme to force very many vcsels to lock together and act as a single coherent laser source our breakthrough a direct outcome of our erc adg employs a unique geometrical arrangement of vcsels on the chip that forces the light to move in a specific path a photonic topological insulator platformwe propose to capitalize on the success and construct proof of concept technology that will bring this topological insulator vcsel array a major step towards commercialization we will design and construct a highly efficient vcsel array on a novel topological platform optimized for reliability and scalability to large numbers of emitters where all the emitters act as a single laser the topological vcsel array will be pumped electrically operating at room temperature and rely on quantum well optimized for emitting high power per emitter we will define the topological insulator geometry with a reflectivitymodulation scheme that ensures reliability our proposed scheme anticipated to be ready within 18 months is scalable to a large number of vcsels and will be a game changer in a plethora of technologies it will pave the way to new applications that require orders of magnitude higher laser power while maintaining high coherence it can revolutionize many applications we use in daily life
hydrogen plasma reduction for steelmaking and circular economy

the main objective of h2plasmared is to develop hydrogen plasma smelting reduction hpsr technology for the reduction of iron ores and steelmaking sidestreams to meet the targets of the european green deal for reducing co2 emissions and supporting the circular economy in the steel industry across europe our ambition is to introduce a near co2free reduction process to support the goal of the paris agreement a 90 reduction in the carbon intensity of steel production by 2050 to achieve this h2plasmared will develop hpsr from trl5 to trl7 by demonstrating the hpsr in a pilothpsr reactor hundredkilogramscale that is an integrated part of a steel plant and in a pilotscale dc electric arc furnace 5ton scale by retrofitting the existing furnace the projects end goal is to establish a way to upscale the process from pilotscale into industrial practice to support this goal the novel sensors and models developed and implemented in the project are used for hpsr process optimization from a reduction resource and energy efficiency standpoint
history of animal governmentality models of animal exploitation and resistance in europe mid17th19th centuries

history of animal governmentality models of animal exploitation and resistance in europe mid17th19th centuries governanimality investigates the different forms of animal exploitation taking place in europe between the mid17th and the 19th century by linking together concepts and practices of human relationships to other animals my aim is to write an epistemological and political history of animal government to this end i use different kinds of historical sources ranging from philosophical naturalistic and economic texts to technical manuals equestrian veterinary and zootechnical works my central question is what are the actual logics of power over animals and how did they change over the course of the modern period by adopting an interdisciplinary approach governanimality intertwines the epistemological problem of the status of living beings in the history of philosophy and science with the material history of animal husbandry this project uses methodological tools that have not been previously employed in the analysis of animal exploitation namely historical epistemology and foucaults genealogy by including the voice of the technicians of animal exploitation who provide abundant testimony of animals needs and resistance this project also aims to restore at least in part the agency of animals moreover it looks at the connections between animal inferiorization and mechanisms of animalisation deployed against a variety of human categories within the context of a growing academic and social interest in the relationship between human societies and nature intensified by recent ecological and pandemic crises governanimality thus provides a critical reflection on the shaping of modern forms of knowledgepower over living beings characterising western societies
spins in twodimensional materials for tunable magnetic and optoelectronic devices

in order for modern information technology to continue progressing at a rapid pace we require smaller devices consuming less energymagnetic materials provide a promising route for nonvolatile memory devices however downscaling them is challenging and information transfer between devices is hindered by short spin relaxation lengths making it necessary to convert spin information into charge currents leading to an increase in power dissipationthe aim of this erc project is to exploit the properties of twodimensional 2d materials to combine highlyefficient magnetic devices with optical communication specifically i propose to seamlessly integrate the unique and highly efficient spinorbit torques sots of 2d semimetals with the excellent optical properties of 2d semiconductorslowsymmetry 2d semimetals present sot symmetries not seen in conventional devices these are ideal for the control of perpendicular magnetic anisotropy ferromagnets as used in modern highdensity memory devices with the added advantage of their small size due to their reduced dimensionality 2d semiconductors show strong lightmatter interaction efficient electric control over their optical properties and low lasing thresholds when combined energyefficient devices can be realized in which nonvolatile magnetic information is optically transported over very large distancesto achieve this goal i will 1 create externally controlled all2d sot devices 2 realize electric tunability of spins and excitons in 2d semiconductors 3 demonstrate electrical spin injection in a 2d semiconductor with spin direction controlled using sots and 4 develop externally controlled 2d spin leds and spin lasersthis project will pave the way for new generations of information technologies addressing fundamental aspects along the way it will enrich the van der waals spintronics field and provide a new strategy towards energyefficient data storage and transport at the nanoscale
greengage engaging citizens mobilizing technology delivering the green deal

greengages vision is to promote innovative governance and help public authorities in shaping their climate mitigation and adaptation policies by engaging with citizens to cocreate green initiatives and to develop citizen observatories co focusing on mobility air quality and healthy living supporting the delivery of carbon neutral neighbourhoods the paneuropean research innovation action will develop innovative governance process deploying digital solutions to transform citizens engagement and cities effectiveness in delivering european green deal objectives for carbon neutral cities green and digital transformation to carbon neutral cities will be promoted via two interrelated project dimensions first the enhancement of intelligence applied to city decision making process and governance by engaging with citizen observations integrated with copernicus geoss insitu and socioeconomic intelligence and delivered by innovative governance models based on novel toolboxes of decisionmaking methodologies and technologies second by harnessing the social and cultural opportunities to promote the active engagement of citizens via cos in the collection and use of urban decisionmaking intelligence supportthe project will achieve the above vision by facilitating citizens to observe and cocreate their cities by sensing their urban environments that will complement validate and enrich information held by the public administrations andor environment agencies derived from remote sensing data and obtained via other authoritative observations this enhanced and evidencebased information will be used for smart urban governance including policy evaluation policy making and decision making greengage increases societal awareness by showcasing the environmental challenges climate change poor air quality healthy living through asis state of the urban environment highlighting the information and other gaps in the authoritative data held by the public administ
3d biofabricated highperformance dnacarbon nanotube digital electronicks

siliconbased cmos technology is approaching its performance limits but the demand for more powerful computers driven by rapid advances in applications such as the internet of things big data and artificial intelligence ai remains the discovery of various nanomaterials provides new opportunities to further develop information processing technology carbon nanotubes cnts have in particular demonstrated excellent properties as a channel material in transistors computers based on cnt fieldeffect transistors fets have been theoretically predicted to provide a powerperformance improvement of ten times over computers based on sicmos technology however the fabrication of highperformance cntnanoelectronics and the realization of the full potential of cnts is highly challenging a technological revolution would be a reliable approach to fabricate a new family of cntbased devices that could enable aligned arrangement of the nanotubes avoiding the critical steps related to nanolithography in particular biofabrication using dnatemplated cnt arrays fets has been demonstrated to further scale the alignment of cnts within the fets well beyond standard lithographic feasibility 3dbricks will raise this concept of integrated selfassembly cntnanocircuits to a completely new level by moving towards the third dimension indeed the versatility of dna nanotechnology will be the root for conceiving 3dimensional 3d cntfets and cntnonvolatile memories dna nanotechnology will also enable to complement the cnt deposition with metallic connections hence realizing a working circuit this will reduce the footprint of the final device while enhancing its efficiency hence providing a breakthrough solution to realize the nextgeneration nanoelectronics furthermore automated dropletbased cntdna assembly selective sorting and deposition based on assembly quality will be an enabling technology towards upscaling production our approach will enable the production of scalable biotemplated electronics that can be extended to multiple applications such as metamaterials sensors optoelectronics and others
ubiquitous inline mass spectroscopy for industrial process monitoring and optimization with sustainable impacts

spectro inlets aims to commercialise the first massspectrometer ms to be used as an integral part of chemicalprocess based industries the spectro inlets liquid gas analyser silga enables for the first time inline realtime measurement and optimisation of processcritical chemical reactions target industries include biogasbased energy generation wastewater treatment food beverage production and pharma representing an 15b opportunity for spectro inlets deploying silga to biogas monitoring will reduce greenhouse gas emission by 2300000 tco2 year in europe and increase the production yield in 515 the technology enabler is a patented microchip inlet system the objective of the ubispec project is to optimise demonstrate and certify silga from already achieved trl6 prototypes to trl9 and full commercialisation in the biogas sector in 5 years from project launch silga will represent 85 of our companys 55m revenues and responsible for 60 new employees
sustainable manufacturing and optimized materials and interfaces for lithium metal batteries with digital quality control

the solid project will create a sustainable and costefficient pilot scale manufacturing process for a high energy density safe and easily recyclable solidstate limetal battery we will use rolltoroll r2r dry extrusion coating for the blend of cathode active material solid polymer electrolyte and conducting additives r2r slot die coated primers on the cathode current collector will enhance adhesion performance and corrosion resistance of the cell the polymer electrolyte layer will be r2r coated using an optimal design for the slot die head for the li metal anode we will utilize costefficient r2r pulsed laser deposition which enables minimizing the li thickness down to 5 m the li metal production will be combined with an inline process for interfacial engineering to ensure compatibility with the other layers and stability the process development will be supported by digitalization methods to go towards zerodefect and costefficient manufacturingthe proposed methods enable sustainable manufacturing of gen 4b solid state batteries with minimised amount of critical raw materials co and li and with superior performance and safety the protective layers enable the use of nmc811 which reduces the amount of co into minimum without compromising the lifetime and pld process helps to minimize the li thickness dry coating eliminates the use of toxic solvents and energyconsuming drying steps and the digital quality control will reduce the amount of waste the thickness of each layer will be minimized to reach energy density above 900 whl cost will be reduced by costeffective production methods and by maximizing the yield safety and long cycle life are guaranteed by the solid electrolyte and the protective interlayers supported by the lifecycle thinking and stakeholder engagement the solid project will enable the design for a sustainable solid state battery factory of the future
feminisms and the mobilisation of law in gulf countries

abstract current literature have tended to analyze feminist activisms in mena almost exclusively from the point of view of their effect on social change broadly defined reemphasising the reifications of women as victims by sharia laws the veil and repressive cultural and political systems in addition scholars have often directed their attention to visible forms of feminist activism including protesting in revolutionary countries such as egypt tunisia lebanon yemen bahrain among others and have marginalised feminisms in stable countries in this context gulffeminisms project is groundbreaking in three ways first it examines the understudied domains of the genealogies of feminisms and the mobilisation of the law in the three gulf states of saudi arabia oman and united arab emirates womens rights in all the three countries are interpretatively but differently operationalized under sharia law abridging womens freedom to fully participate in decisionmaking processes at the national level while established scholarship has provided valuable studies of how patriarchal religious and political authorities use legal and religious frameworks to repress feminists maintain gendered inequalities and restrict womens rights this project shifts the established scholarly perspective by examining how feminisms in the gulf are selfmotivated political movements that mobilise laws including sharia to operationalise womens agencies and practices within private and public spheres and to generate political change second gulffeminisms offers an original and leading perspective on feminisms in mena as a practice promoting positive social and political change third to analyse the relation of feminisms and the mobilising of the law gulffeminisms combines the multidisciplinary novel comparative analytical framework of feminist comparative policy theory fcp and epstein and martins 2004 approaches to qualitative and quantitative empirical law research
trampoline a training programme to promote the industrial adoption of microbial electrochemical technologies

a training programme to promote the industrial adoption of microbial electrochemical technologiestrampoline is a joint academicindustrial interdisciplinary initiative which has the primary goal of training a pool of young researchers in the field of microbial electrochemical technologies mets while developing innovative and readytobeapplied solutions for tacklingglobal environmental challenges including contamination of the remaining freshwater sources unsustainable production processesanthropogenic co2 emissions and the transition towards renewable energy environmentthe main aim of trampoline is to form a collaborative network that i connects leading researchers in the core met disciplines with smelarge companies ii upgrades the stateoftheart sota of mets into prompt industrial adoption and iii trains a set of young researchers to become highly skilled met scientists due to the multidisciplinary nature of mets the upgrading of metbased cuttingedge technologies calls for international intersectoral cooperation in view of its proper industrial adoption the doctoral training is carried out in research groups that are developing progressive technologies and materials for applying mets with active involvement of industrial partners that can support the market adoption of the technologies the candidates will be developing metbased technologies focusing especially on bioremediation desalination industrial bioproduction resource recovery and on the production of co2based chemicals comprehensive technology development is supported by the work packages dedicated to microbiology of electroactive microorganisms engineering redox reactions and reactors innovative materials metbased industrial bioproduction environmental applications and industrial adoption