Dragon09/odtu_chatbot huggingface dataset:
geoarchaeology of ancient burials in their environment

the richest archive of archaeological and environmental information in any site is not the artifacts or the buildings but rather the soil and sediment which cover them the sediment matrix of ancient cemeteries is a complex archive of sociocultural and environmental change an archive which is often overlooked by researchers graben employs a diverse methodological and theoretical toolkit to reconstruct burial traditions from sites in greece denmark and norway the proposed project employs a diverse toolkit of geoarchaeological techniques including elemental and mineralogical analysis via xray fluorescence fourier transform infrared analysis microscopic analysis thin section soil micromorphology and scanning electron microscope and luminescence profiling portable optically and infrared stimulated luminescence to reconstruct the soil environment of graves and the sequence of human actions and natural processes which created them graben will address the formation of cemetries at three levels the planning construction and use of the cemetery itself the excavation and use of the graves themselves and the soil environment of the graves and how it impacts the preservation of skeletal remains and important biomolecular evidence such as dna and isotopes importantly graben will address a wide variety of burials including stonelined and soil pits burials with and without a coffin historic and prehistoric bronze age and christian and prechristian this novel and innovative project encompasses both cooler wetter climates and warmer drier climates allowing for better observation of how variations in the speed of decay affet the burial processes and the preservation of the burial this data will be used to better understand variations in community practices of burying the deceased and reusing the graves as well as the soil conditions of the cemetery and how they impact the preservation of the remains and other evidence of funerary practice
the potential of research data how research infrastructures provide new opportunities and benefits for society highlevel presidency conference on research infrastructures

europe has one of the most advanced and integrated research infrastructure systems in the world during the last years europe has invested large sums in research infrastructures ie stateoftheart experimental facilities to reinforce europes research and innovation system by providing research communities with unique expertise instruments technical resources data and services this facilitates the performance of cuttingedge basic and applied research boosting of technological advancements and breakthrough innovations they also bring benefits to industries and smes research infrastructures provide knowledgebased solutions to societal challenges and aids in the delivery of the eus green and digital transitions research infrastructures is a top priority for the current trio of french czech and the swedish presidencies of the european council the objectives of the swedish presidency conference on research infrastructures aremaking research infrastructures more visible by directing towards the capabilities of reusable and open data for research and societal benefits sensu latoidentifying challenges and means to face them by increased collaboration between sectors and stakeholdersaccelerating the creation of values from research infrastructures by further developing and strengthening the work with reusable and open data for producers and consumersthe conference is arranged in lund a high impact research and research infrastructure hub bringing together 250 people from a range of sectors from different levels that benefit from research infrastructures and open data and science to discuss relevant topics the values foreseen after the conference are further strengthening of research infrastructures and facilitation of broader success to them aid of future funding of these facilities increased trust in science and contribution to the competitiveness of european society and economy
nitrogen chemistry with alkalineearth metals

nitroearth is aiming to investigate the hardly explored nitrogen chemistry of the alkalineearth metals ae in order to disclose new reactivity and catalysis in the biogeochemical nitrogen cycle oxidized nox neutral n2 and reduced nh3 forms of n are interconverted by a complicated network of processes in contrast manipulation of n in industry is challenging and often needs bruteforce methods the haberbosch process for n2tonh3 conversion is despite being metalcatalysed one of the most energy consuming industrial processes this proposal focusses on the organometallic chemistry of imido rn2 and nitrido n3 complexes of the alkalineearth metals in particular mg and ca while the amide r2n chemistry of the ae metals is wellestablished aeimido complexes are rare and aenitrido compounds solely exist as insoluble salts eg mg3n2 given the importance of imido and nitrido ligands in transition metal chemistry access to soluble aenr and aen complexes promises a rich reactivity and is the prelude of new catalytic processes based on abundant generally biocompatible alkalineearth metals the various pathways to reach the target include utilization of recently introduced highly reducing mg0 complexes by harder and nitreones which have been investigated by patel also harders recently discovered n2 fixation with ca will play a role in the synthetic approach owing to the highly ionic character and negative charge on n in aenr or aen complexes these novel complexes will be extremely potent nucleophiles or deprotonating reagents this will be strongly dependent on nuclearity and aggregation which will be controlled by a library of bulky ligands currently available in the harder group the work will be heavily supported by ab initio calculations the project ultimately leads to the generation of a new class of alkalineearth metal catalysts which may provide sustainable alternative for transition metal based catalysts
neuromuscularcognitive interactions in sensorimotor decision making

successfully interacting with ones environment requires a rich interplay of perceptual judgement and neuromuscular control with each taking account of the other in real time miscalculations in this accounting as happens in demanding sensorimotor tasks eg sports cognitive and motor disorders or with agerelated decline can have serious consequences despite the huge growth in modelling and neurophysiological studies of perceptual decision making the critical role played by neuromuscular processes has been largely neglected due to challenges in parsing distinct effects of sensory cognitive and motor processing in the brain our recently developed computational framework for jointly modelling behaviour with wellcharacterised neurophysiological signatures of sensorimotor decision formation now provides a means to overcome this parsing problem offering a window onto the hierarchy of cortical processing involved myodecision will capitalise on this advance to develop new decision paradigms that interface directly with muscle outputs making the participants active agents in meeting changing neuromuscular demands and hence resolve major outstanding questions regarding how sensory and motor systems interact in the brain first i will investigate how people adjust sensorimotor processes to meet changing time and effort demands on their motor outputs including finegrained manipulations of muscleactivation strength requirements speed pressure and effort biases then using open and closedloop stimulus perturbations i will probe how these processes underpin dynamic changes of mind that rescue erroneous behaviours finally i will develop a robust approach to neurallyconstrained modelling aimed at examining individual differences in decision making in challenging sensorimotor environments this work will offer the field a transformative paradigm for probing latent psychological processes in more ecologically representative decision scenarios
intent and contextaware optical networks

the intent and contextaware optical network icon project builds the research foundation for a new generation of optical networks in which sensing is designed as an integral part of overall system architecture icon will enable communication networks that offer sensing services turning the terrestrial and subsea fibre infrastructure into a global scale sensing manifold this will pave the way for future network evolution of services offering a wide range of sensing applications in diverse areas such as geological disturbances global weather and oceanographic phenomena and urban mobility the control and management of such new sensing services will be enabled by extensible and modular icon intelligent sensing controller that include an intent interpreter and network digital twin to preserve state information as an integral part of future communications systems the icon functions and sensing devices enable transmission optimization that goes beyond todays signal monitoring the icon project will develop fibre sensing and controls to create context awareness of both the internal fibre system state as well as the environment encompassing it this addition of a sensing dimension to transmission engineering in optical networks brings new tools for optimizing transmission performance and increasing availability and energy efficiency
application of organic polaritonics to postsynthesis improvement of singlet fission in molecular dimers

strong lightmatter coupling sc is increasingly proposed as a powerful tool for postsynthetic control of the optoelectronic properties of organic materials this technology aims to exploit the easily tuneable polariton states arising from the sc between confined light fields and excitons in organic materials to rewrite molecular energy landscapes and redirect physical pathways singlet fission sf is a promising technology for improving the efficiency of photovoltaic solar cells beyond their theoretical limit the sf process consists of the splitting of a singlet excited state into two entangled triplettriplet states that later become two independent triplets yielding up to two excited states per absorbed photon hence more efficient solar cells despite its great potential sf has been observed only in a limited number of organic compounds and in many cases with a low efficiency being the synthesis of new derivatives a huge challenge recently some theoretical studies proposed sc as a postsynthesis solution to enhance the sf performance of inefficient materials by controlling their energy landscape however the growing difficulty in reproducing key results in the field of organic polaritonics op suggests a poor understanding of the involved phenomena the major research ambition of this msca proposal is to understand the working principles in the op field and demonstrate that sc can be exploited to enhance the sf efficiency the implementation of this msca proposal will provide a deep knowledge of sc at the molecular scale and how to control it at the macroscale within polaritonic devices realizing the postsynthetic control of the molecular properties this achievement will lead to important breakthroughs in materials science and photonics setting the basis for the op field besides the proposed research and training activities will expand my experience research expertise and networks providing a boost to my career as an independent researcher
role of extracellular matrix as regulator of ageing through mechanosignaling

a recent work published by the host laboratory had redefined aging as a mechanodisease transcriptional cofactors yaptaz masters of mechanotransduction were critical in stromal cells to prevent aging importantly restoring cellecm communication and yaptaz level was sufficient to rejuvenate old cells consequently we hypothesize that the culprit of aging should be searched in ecm changes that drive the loss of mechanotransduction in stromal cells using single cell rnasequencing data of mouse dermal fibroblasts and massspec analyses of the dermis ecm during aging we will seek for ecm candidates that may be at the root of this process then we will build an atlas of the mouse skin during aging using spatial transcriptomic and immunolabeling of mechanoresponsive proteins to unveiled new interconnections between the ecm and altered mechanotransduction during aging as validation we will use two complementary in vitro approaches first old mice fibroblasts will be culture on a young ecm synthetized by engineered young mice fibroblast lacking specific ecm genes pinpointing to ecm proteins able to rejuvenate old cells second we will generate 3d organotypic skin culture with keratinocytes and engineered dermal fibroblast lacking specific ecm candidate we will ask whether it affects mechanosignaling and acquisition of aging traits in both dermis and epidermal compartments digging into the mechanics of aging is crucial because it would add a new paradigm on the causes of cell senescence and aging define new markers for healthy aging and inform on new therapeutic perspectives to combat aging or some of its associated pathologies
future of alcl novel therapies origins biomarkers and mechanism of resistance

the fantom doctoral network dn composed of 7 beneficiaries and 12 associated partners in 5 eu countries recruiting 10 researchers and will be embedded into an established international research programme the european research initiative on anaplastic lymphoma kinase alkrelated malignancies eria as well as a clinical network the european intergroup for childhood nonhodgkin lymphoma eicnhl fantom will cosset and nurture the recruited researchers to become confident competent independent and wellconnected european scientists with excellent career perspectives welcomed into these established networks this will be achieved through a training programme conducted through research and complemented by a balanced programme of transferable skills designed with key input from both academic and industrial collaborators the training of each fellow will be guided by an individual career development plan and supervised by a phd committee with clearly allocated academic and industrial supervisors the primary goal of the network is to train the recruited fellows by participation in an internationally competitive research programme and integrating them into the aforementioned networks the research programme will address the clinical problems posed by anaplastic large cell lymphoma alcl typified by aberrant alk expression applying innovative model systems and multiomics technologies some performed to a single cell level the biology of alcl including the roles of the immune system and tumour stroma will be uncovered these data will be applied to the development of noninvasive biomarkers and novel therapeutic approaches that will culminate in the design of clinical trials to address the issues of chemotherapy toxicity overtreatment and drug resistance the research and training activities will incorporate not only academic labs but also key research institutes biotechnology companies clinical trial bodies and pharma to realise our research goals
integrated modular multisensing mid and near ir sensing platform

photonicsbased sensing in the midir been proven to be the key technology for highly efficient sensing in a plethora of applications ranging from environmental monitoring to industrial process control medical diagnostics water quality safety applications medical and more related to other sensing approaches midir spectroscopybased sensing enables the fast reliable and consumablesmaintenancefree operation for the detection of trace amounts even in the subppb range to high concentration of the targeted analytes the interest in the technology has been significantly increased due to the maturing of the quantum cascade lasers qcls qcls offer an up to 2orders of magnitude enhancement in the signaltonoise ratio while enabling the direct access to the characteristic molecular fingerprint region of the targeted analytes m3nir develops very innovative currently at trl2 midir sensing approaches to significantly boost the technology in terms of performance low limit of detection multiplespecies detection footprint cointegrating of lasers and components reduction of energy consumption and cost for the latest two m3nir implements detectorfree sensing by means of the selfmixing detection scheme moreover the combination of midir and nearir components in photothermal sensing is yet another approach for the implementation of miniaturised energy efficient and lowcost advanced sensory system to accomplish its goals m3nir cointegrates advanced electronics and data processing units in the systems as well m3nir demonstrates its novel approaches at trl5 for the monitoring of ghg and ships emission a dronemounted sensor to be demonstrated detection of phosphates and nitrates in water and the breath analysis for health and wellbeing related applications
presence and role of organic matter in icy satellites and extrasolar planets

there is growing evidence that heavy organic molecules are a major component of the outer solar system bodies such as icy moons comets and transneptunian objects tnos density profiles inferred from measurements of space missions require a lowdensity component in the core of the largest objects such as ganymede and titan these observations suggest that a previously overlooked lowdensity component identified as carbonaceous organic matter com is one of the three main components in addition to ice and rocks building planetary bodies that formed beyond the ice line however there is a dearth of laboratory experiments and numerical simulations exploring the interaction of the heavy organic molecules constituting the com with both the ice component mainly h2o ices and the rocky component hydrated silicates oxides and sulphides at pressures relevant to icy moons observations from space missions also demonstrated that most icy moons are differentiated into a refractory core and an outer hydrosphere that includes a liquid layer deep ocean thus the name of ocean worlds this raises the questions of the emergence of life at the oceancore interface and of the habitability of ocean worlds how does the presence of com affect the thermal and chemical evolution of ocean worlds the interaction between com ice and rocks is therefore essential for understanding the evolution of ocean worlds and for assessing their habitability potential first this project conducts laboratory experiments using diamond anvil cells dac coupled with in situ raman spectroscopy a combination that is best suited for this kind of investigation second it develops a thermochemical evolution model that can handle the chemical reactions and the thermochemical properties of the three components third it applies the results to the evolution of ocean worlds in our solar system and beyond
rigorous approximations for manybody quantum systems

from first principles of quantum mechanics physical properties of manybody quantum systems are usually encoded into schroedinger equations however since the complexity of the schroedinger equations grows so fast with the number of particles it is generally impossible to solve them by current numerical techniques therefore in practice approximate theories are often applied which focus only on some collective behaviors of the systems in question the corroboration of such effective models largely depends on mathematical methods the overall goal of rambas is to justify key effective approximations used in manybody quantum physics including the meanfield quasifree and randomphase approximations as well as to derive subtle corrections in critical regimes building on my unique expertise in mathematical physics i will 1 develop general techniques to understand corrections to the meanfield and bogoliubov approximations for dilute bose gases 2 introduce rigorous bosonization methods and combine them with existing techniques from the theory of bose gases to understand fermi gases and 3 employ the bosonization structure of fermi gases to study the manybody quantum dynamics in long time scales thus deriving quantum kinetic equationsby applying and suitably inventing mathematical techniques from functional analysis spectral theory calculus of variations and partial differential equations rambas will take standard approximations of quantum systems to the next level with special focus on those particularly challenging situations where the particle correlation plays a central role but is yet not adequately addressed rambas will thereby provide the physics community with crucial mathematical tools which are at the same time rigorous and applicable
ai and machine learning assisted development of greener formulations and pharmaceutical processes based on amorphous solid dispersions

this proposal is bringing together ri related staff by a complementary set of participating organisations that will use multidisciplinary technological approaches to provide a proofof concept framework for designing and introducing greener practices in pharmaceuticals knowledge will be transferred around the core technical activity that will be the introduction of hme as a novel production method based on aiml tools and supported by environmental assessment for greener pharmaceuticals
microbially mediated particulate organic carbon flux

particulate organic carbon generated by primary production in surface waters is exported into the oceans interior through the biological pump contributing to the regulation of atmospheric carbon dioxide and partial sequestration of ocean carbon microbial transformation mechanisms on sinking aggregates directly impact the quantity and quality of organic matter reaching the deep sea due to their importance in biogeochemical cycles sinking particles and their microbial components have received increasing attention in the past few years however microbial interactions and mechanisms involved in particle formation and degradation remain largely unexplored the overarching goal of the current project is to explore for the first time the specific functions of particleassociated prokaryotes in determining the fate of sinking particulate organic matter pom first aim is to investigate in situ the rnabased functional and genomic characteristics of sinking particleattached microbes over time at different depths using metatranscriptomics and metagenomics analyses we also aim to elucidate the proteinbased functional profiles of microbial communities on sinking particles and uncover linkages between microbial enzymes involved in the degradation of pom using a comparative metaproetomics and metagenomics approach additionally we aim to examine the carbon uptake metabolic activity and colonization patterns of sinkingparticleattached microbes using stable isotope probing coupled with amino acid tagging and liquid chromatography mass spectrometry it is anticipated that the insights provided into microbially mediated processes regulating pom transformation will set the basis for better understanding the oceanic carbon cycle and further improve predictions on future ocean biogeochemical cycles and climate change