Dragon09/odtu_chatbot huggingface dataset:
new paleo reanalysis for improved understanding of pacific decadal variability

the pacific decadal variability pdv characterises the fluctuations in sea surface temperatures across the pacific ocean over decadal to multidecadal timescales as the primary driver of variability at these scales pdv exerts a significant influence on the climate in surrounding regions it contributes to significant regional climate events such as floods and bushfires while also playing a pivotal role at the global scale by amplifying and mitigating humaninduced global warming despite a significant effort in recent years to understand the root mechanisms of pdv our understanding remains hampered by the limited duration of instrumental observations that mainly cover the 20th century with large undercovered subregions it ultimately inhibits the study of longerterm climate variations and especially the role of ocean dynamics this knowledge gap significantly hampers our confidence in climate projections for the next few decades particularly at the regional scale based on the knowledge of the applicant on the use of paleoclimate proxies combined with climate models to retrieve past climate changes and the expertise of the host institution on data assimilation and climate dynamics prey4pdv aims at providing the first paleoclimate reanalysis taking into account the exchanges between the atmosphere and ocean in the pacific using a stateoftheart earth system model over the past 500 years using the product together with sensitivity numerical simulations we will investigate the critical drivers of the multidecadal variability in the pacific during this fellowship i will transfer my knowledge in using paleo records within an earth system model to the host institution while learning stateoftheart data assimilation methods running numerical simulations and tropical climate dynamics from the host institution therefore this fellowship will place me at the forefront of an emerging scientific topic by applying stateoftheart paleo data assimilation
bayesian inference with flexible electronics for biomedical applications

the long term vision in bayflex is to create a radically new technology that uses low cost green organic electronics for probabilistic computing in order to allow continuous and private monitoring of biosignals on flexible substrates the vision of flexible green ai sensors with on chip classification extends well beyond biomedical devices and the democratization of health care with the possibility to transform sensor data at the edge of large networks to achieve our goal bayflex will demonstrate a patch using active physiological sensors based on organic materials that interface with the soft human body and that also includes classification circuits 100 transistors fabricated using thin organic large area electronics tolae processes these circuits use spiking neurons realized in organic thin film transistors otfts to transform the nonstationary electrical signals from the sensors into stochastic bit streams bayesian inference is then used to classify the data using circuits of cascaded muller celements taking advantage of the unique properties of organic electrochemical transistors oects low transistor count dynamic muller celements are targeted the patch will be tested on a simple task using healthy humans the project brings together an interdisciplinary consortium with expertise in modeling emerging devices biologically inspired circuit design experts in machine learning involving electrophysiological data including an sme and teams with expertise in otft and oect fabrication bayflex targets dissemination to a variety of publics including scientists via publications in open access high impact journals and conferences industrials and endusers through an industrial advisory board a workshop and demonstrations at targeted conferences the general public with the creation of a transferable workshop for nonscientific communities and training the next generation of experts through specialized schools and workshops
harnessing the market potential of singleatom catalysts through nextgeneration largescale synthesis

the catsynex project born from the ercstg sac20 project addresses the pressing need for scalable production of singleatom catalysts to revolutionize industrial catalysiswhile homogeneous catalysts dominate pharmaceutical synthesis due to their precision they suffer from recovery instability and cost issues heterogeneous catalysts offer easier separation but struggle with lower degree of selectivity and activity when used in pharmaceutical reactionssingleatom catalysts bridge this gap offering atomically precise control during catalyst formulation enhanced catalyst stability higher turnover frequencies and reduced material costs however current synthesis methods limit singleatom catalysts to laboratory scale catsynex aims to change this by developing scalable sac production methodsthe scientific validation involves optimizing sac synthesis for uniform dispersion and high catalytic activity ensuring reproducibility across batches and scaling to industrial quantities catalytic performance will be tested against traditional catalysts to showcase sac superiority at different scales from mg to kg and over multiple catalytic cycles business validation includes analyzing ip landscape regulatory framework market appeal and manufacturing economicsthrough catsynex sacs are poised to become valuable tools for various chemical industries driving innovation by making pharmaceutical synthesis more efficient more sustainable and costeffective and addressing some of the pressing critical challenges of the 21stcentury manufacturing processes
satellite construction kit for highly unified modular assembly in newspace applications

this proposal addresses subtopic 1 ri on new scalable satellite platform concepts and building blocks increasing the degree of satellite modularisationschumann ambitions to strengthen the foundations of the future space ecosystem by means of 2 complementary developments 1 a functional spacecraft module fsm consisting of a refuelable tank rta along with a refueling experiment setup to support the testing and qualification of this module this fsm will demonstrate that a side standalone module development by following appropriate design rules and leveraging previous og developments can be integrated at a late stage into an iod mission2 a design and development specification for the spacecraft construction kit dssck consisting of a specification and tools aimed at guiding and supporting fsm developers to make their modules compatible and usable in a single ecosystem
dynamic highperformance open radio access network technology

future 5g radio access networks rans are built of virtualised software modules and cots server hardware to meet the stringent data throughput and latency requirements of 5g the software must be highly optimized for performance and energy efficiency but here a new problem arises existing vran software is tied to a specific hardware usually by the same vendor which reintroduces hardware lockin open ran specifies hardwareagnostic software standards to foster upgradeability adaptability and vendor diversity but implementations of this standard for fully hardwareindependent open ran software do not exist today as an industry first xelera dyra provides a hardwareindependent standardcompliant open ran software xelera dyra will be a highperformance energyefficient distributed unit du software which is a critical component of an open ran system this product is important for the european open ran ecosystem because of the lack of established european suppliers
fibrestoration novel specialized probiotics for restoring a healthy fiberdegrading microbiome

dietary fiber is wellrecognized as beneficial to gut microbiome and has repercussions on human health consequently in recent years alternative dietary lifestyles favoring the consumption of high amounts of dietary fibers have been proposed in order to avoiddigestive discomfort associated with the increased intake of dietary fiber we propose to develop probiotics that will target cellulose the main component of dietary fiber indeed cellulosedegrading bacteria are absent both in gut microbiomes of most human populations and in existing probiotics during our proposed project we will isolate unique fiberdegrading bacterium and restore it in the human microbiome via administration of probiotics thus our products will comprise this bacterium either alone or in combination with other fiberdegrading strains and will augment the fiberdegrading potential of the human gut microbiome with concomitant implications in human health such probiotics will address the majority of global human populations and will constitute a niche in the global probiotics market which is projected to further increase in the next decade
symplastic dynamics of root cells

roots must tightly balance uptake of ions and water from the soil into their vasculature for this purpose they developed complex systems of barrier mechanisms the endodermis layer encircles the vasculature and via the casparian strip cs and suberin acts as such a barrier the cs blocks flux outside of cells the apoplastic flux and leaves only the symplastic pathway open for the exchange of molecules endodermis cell walls undergo suberisation dependent on phloem pole pp or xylem pole xp association the unsuberised xp associated endodermis xpae cells are speculated to fulfil an important role as transport highways despite this close association to the underlying vasculature little is known about the dynamics of endodermal symplastic flux in the different polesi aim to elucidate differences in the celltocell exchange of the endodermis in relation to barrier status and radial positioning for this i will use a photoconvertible fluorophore to quantify symplastic flux by xp versus pp association and suberisation status next i will generate tools to specifically manipulate xpae cells by forcing them to close off their symplastic connections by plasmodesmal callose deposition or to undergo suberisationi will use these tools to assess phenotypic differences on plant growth under stress conditions that affect endodermal barrier development eg low iron phosphate and zinc together this will result in unprecedented insights into how the endodermis achieves the specific transport of water and ions and will allow me to update models with radial information on endodermal selectivity and connection to vascular transport
european research infrastructure for marine bioprospecting

the main objective of the euremap consortium is to optimise the marine bioprospecting pipeline in europe to enable stateoftheart research and capacity for both academia and industry the ambition is to leverage strengths available within european research infrastructures ris and to align capacities and resources of the multidisciplinary field of marine bioprospecting hence to increase the competitiveness of marine natural products in the field of drug discovery and to strengthen the blue bioeconomy in europe we will assemble a new pipeline that aligns and integrates the existing technical capacities and multidisciplinary expertise of the three european ris euopenscreen euos embrc and elixir in the field of marine natural products discovery euremap will develop a unique transri integrated service in an european priority area the blue economy the pipeline will be an important part of the european blue growth strategy to stimulate economic growth through innovations in marine biotechnology the potential for innovations and value creation in the blue biotechnology sector is high and the sector is characterised by being multidisciplinary knowledgeintensive and built on technology building a new european transnational ri service platform to support the competitiveness of an academic and industrial community in all aspects of this multidisciplinary field euremap will bring together an experienced multidisciplinary consortium across three ris to support and enable the discovery of novel bioactive natural products from marine organisms by utilizing novel technology to improve the capacity of european ris
developing the next generation of cistargeting macrophaget cell cancer immunotherapies

immunotherapy holds great promise for the curative treatment of millions of cancer patients with a market size of over 100 billion usd today which is expected to at least double in the next decade cancer immunotherapies are designed either to promote antitumor immune activity in the tumor microenvironment tme via molecules such as cytokines and antibodies or to inhibit negative t cell signals induced by cancer and antigenpresenting cells apcs in the tme an approach known as immune checkpoint blockade icb yet current immunotherapies have shown significant clinical success only against a limited number of cancers for two major reasons insufficient antitumor immune activation or severe side effects and toxicity as a result of nonspecific immune activation we propose to overcome these two challenges through the development of a novel class of molecules capable of simultaneously modulating the myeloid and lymphoid immune cell compartments in the tme and generating a highly specific and extremely potent antitumor immune response in this poc grant we seek to validate the ability to construct such dualmodulatory agents which will provide us with the proofofconcept for these technologies
aiassisted cybersecurity platform empowering smes to defend against adversarial ai attacks

in recent years the digital environment and digital transformation of enterprises of all sizes have made aibased solutions vital to missioncritical aibased systems are used in every technical field including smart cities selfdriving cars autonomous ships 5g6g and nextgeneration intrusion detection systems the industrys significant exploitation of ai systems exposes early adopters to undiscovered vulnerabilities such as data corruption model theft and adversarial samples because of their lack of tactical and strategic capabilities to defend identify and respond to attacks on their aibased systems adversaries have created a new attack surface to exploit aisystem vulnerabilities targeting machine learning ml and deep learning dl systems to impair their functionality and performance adversarial ai is a new threat that might have serious effects in crucial areas like finance and healthcare where ai is widely used aias project aims to perform indepth research on adversarial ai to design and develop an innovative aibased security platform for the protection of ai systems and aibased operations of organisations relying on adversarial ai defence methods eg adversarial training adversarial ai attack detection deception mechanisms eg highinteraction honeypots digital twins virtual personas as well as on explainable ai solutions xai that empower security teams to materialise the concept of ai for cybersecurity ie aimlbased tools to enhance the detection performance defence and respond to attacks and cybersecurity for ai ie protection of ai systems against adversarial ai attacks
physics departments culture structure and gender inequality

the discipline of physics has been grappling with the issue of gender imbalance for decades the underrepresentation of women in physics profoundly affects the growth and future of the field by contributing to a loss of potential talent and deprives industry of the intellectual contribution of women with a physics background those women physicists who enter the workplace remain dramatically outnumbered especially within senior management the persistence of this gender imbalance suggests that it is due to a combination of many factors interacting dynamically in complex ways necessitating holistic and integral solutions interventions so far have been generic and have focussed overwhelmingly on the microlevel individual learner teacher employer and family the thesis of this project is that measures taken to increase representation will be effective only when they include addressing underlying hidden structures of the physics culture that contribute to the gender inequality in order to unpack the factors that shape how physics engages with women this work employs semistructured artefactbased ethnographic interviews of thirdlevel students physics and nonphysics and physics academic staff drawn from two institutions in culturally different environments an interdisciplinary framework will be established to articulate structures representations policies and practices that contribute to the gender inequality in thirdlevel physics education the processes involved will identify the tangible structural changes that can be implemented the outcomes of this work will empower physics departments internationally to move beyond generic strategies and to implement tailored action plans to address gender imbalance by ongoing collaborative selfreflexivity these processes and outcomes are transferable to other underrepresented populations in stem fields and careers and hence carry academic and economic implications
hydrogen bond networks as optical probes

fluorescence takes place throughout the natural world most conventional chemical wisdom proposes that in organic entities fluorescence occurs in conjugated systems such as in the aromatics however in biological settings the interaction of light with matter occurs in media built up of dense networks of hydrogen bonds recent experiments suggest that it is possible to observe fluorescence from these networks too this could open the possibility of designing hydrogenbond networks with enhanced fluorescence offering enormous fundamental and practical potentialthe overarching goal of hybop is to decipher using advanced computer simulations the exotic optical properties of hydrogenbond networks and to harness them as probes of watermediated forces to achieve this hybop will tackle the following challenges1 establish the ground rules for creating fluorescent hydrogenbond networks in biological materials 2 understand how to drive the electrons and nuclei of water networks into regimes where they can fluoresce 3 use the optical behaviour of these networks to probe hydrophobic forces in nature to uncover the complex chemistry of hydrogenbond network fluorescence and guide the discovery of new fluorophores we will deploy state of the art electronic excitedstate molecular dynamics in combination with machinelearning techniques this will provide hybop with groundbreaking knowledge which will lay a theoretical framework to motivate development of new experimental probes of hydrophobicityhybop seeks to bring hydrogenbond networks to the forefront of chemistry in their use as optical probes by laying the theoretical groundwork for designing noninvasive fluorophores in biophysics opening up a new window into the origins of autofluorescence in medical diagnostics and finally provoking frontier electron and nuclear spectroscopy hybop will have a spillover effect and build new synergies across several branches of the physical sciences
astrocent plus particle astrophysics science and technology centre

the prime objective of the project is to uplift the existing centre of excellence astrocent by transforming it into a fully independent interdisciplinary new legal entity astrocent plus particle astrophysics science and technology centre astrocent plus will engage in cuttingedge research and development in astroparticle physics and in related aspects of innovative technology addressing global challenges such as healthcare climate change and sustainable sources of energy as a fully autonomous entity with a modern professional management and administrative structure it will be the first scientific institution in astroparticle physics supported by teaming for excellence and the first one in the field in poland acting in close cooperation with worldleading consortium partners astrocent plus will be embedded in a network of international collaborations involved in frontier research probing the invisible universe through neutrino cosmicray gravitationalwave and dark matter detection astrocent and the field have a proven record of medical and commercial applications and after the uplift will bring further highimpact benefits to society and economy the buildup of internationallyrooted research capacity gained through strategic partnerships will position the centre to achieve a significant measurable improvement in research and innovation culture and longterm financial sustainability in part through commercialisation the centre will improve mobility and gender balance train new cadres of highlyqualified researchers in science and hitech industry promote innovation and cooperation between scientists and industry and help poland and the eu attain a competitive position in the global value chains with modern management practices astrocent plus will become the main hub for the rapidlydeveloping field of particle astrophysics and a role model for poland and the region for excellence in basic sciences and fruitful cooperation with industry
coupled flow processes in fractured media across scales insights into hydraulic fracture growth and radiated seismic energy

actively seeking viable cleangreen energy sources is essential for human to maintain sustainable development geothermal energy provides an important alternative to fossil fuels and gas in our life however most geothermal resources are deepseated and are either deficient in fluid or permeability or both the deepseated dry and tight geothermal reservoirs need to be hydraulically fractured for permeability improvement thereby promoting fluid circulation and the harvest of heat energy for electricity production this is often referred to as enhanced or engineered geothermal systems egs understanding the mechanisms that underpin the link between hydraulic fracture geometry and fluid injection scheme under heterogeneous geothermal reservoir conditions is essential in efforts to reduce the fluidinjectioninduced seismicity during egs creation and production within coffee i will combine a multiscale laboratory centimetre scale field decameter scale and reservoir kilometre scale approach to for the first time look at how the 3d hydraulic fractures propagate under geothermal reservoir conditions my expertise with rock mechanics and discrete element method modelling and the vast knowledge on geothermal energy and advanced laboratory and field facilities at the host organisation will definitely create the optimal environment to deliver the objectives of coffee and promote the transfer of knowledge between all participants the fellowship will be highly beneficial to establish myself as an independent researcher and junior professor at a leading european university with this innovative multiscale framework i will improve the understanding of 3d hydraulic fracture growth in heterogeneous geothermal reservoirs this understanding will provide insights on how to reduce fluidinjectioninduced seismicity the outcome of coffee can be used as a benchmark for geoscientists and policymakers in further exploring and optimising enhanced geothermal systems