Dragon09/odtu_chatbot huggingface dataset:
ecosystem for rapid adoption of modelling and simulation methods to address regulatory needs in the development of orphan and paediatric medicines

eramet will provide an integrated approach for developers and regulators decisionmaking for paediatric and orphan drugs centred on the drug development questions this will constitute a transparent ecosystem for drug development and assessment that will facilitate the adoption of modelling and simulation ms methods and related data types including real word data such as registries and electronic healthcare datathe overall objective of eramet is to provide and implement a framework for establishing the credibility of ms methods and related results as sources of evidence within regulatory proceduresthe ecosystem proposed by eramet will be based on three pillars 1 a repository connecting questions data and methods2 the development and validation of highquality standards for data and analytical methods including ms and hybrid approaches these will cover computational ms digital twins ai hybrid approaches standard statistics and pharmacometrics as analytical methods and alternative data types and sources such as rwd ehealth data registries historical regulatory submissions scientific and nonclinical trials 3 an aibased platform that will automate and optimise the data collection formatting and modelling and simulation analysis and implement the credibility assessment as part of eramet the ecosystem will be applied to five usecases including paediatric extrapolation and characterisation of drug benefitrisk in 4 groups of rare diseases namely ataxia transfusion dependent haemoglobinopathies bronchopulmonary dysplasia and paediatric tuberculosiseach of the usecase is planned to lead to submission and regulatory approval of at least one validated ms tool via the ema qualification procedure training will be proposed to familiarise regulatory assessors drug developers and clinical researchers with this new approach
psychstrata a stratified treatment algorithm in psychiatry a program on stratified pharmacogenomics in severe mental illness

a key problem in mental health is that up to one third of patients suffering from major mental disorders develop resistance against drug therapy however patients showing early signs of treatment resistance tr do not receive adequate early intensive pharmacological treatment but instead they undergo a stepwise trialanderror treatment approach this situation originates from three major knowledge and translation gaps i we lack effective methods to identify individuals at risk for tr early in the disease process ii we lack effective personalized treatment strategies grounded in insights into the biological basis of tr and iii we lack efficient processes to translate scientific insights about tr into clinical practice primary care and treatment guidelines it is the central goal of psychstrata to bridge these gaps and pave the way for a shift towards a treatment decisionmaking process tailored for the individual at risk for tr to that end we aim to establish evidencebased criteria to make decisions of early intense treatment in individuals at risk for tr across the major psychiatric disorders of schizophrenia bipolar disorder and major depression psychstrata will i dissect the biological basis of tr and establish criteria to enable early detection of individuals at risk for tr based on the integrated analysis of an unprecedented collection of genetic biological digital mental health and clinical data ii moreover we will determine effective treatment strategies of individuals at risk for tr early in the treatment process based on paneuropean clinical trials in scz bd and mdd these efforts will enable the establishment of novel multimodal machine learning models to predict tr risk and treatment response lastly iii we will enable the translation of these findings into clinical practice by prototyping the integration of personalized treatment decision support and patientoriented decisionmaking mental health boards
engineering phosphorescent and tadf small molecules for white lightemitting electrochemical cells

lightemitting electrochemical cells lecs are getting much attention as singlelayered costeffective airstable electrodes spray deposition tolerance to 3d substrates and moderate performing devices to date the best emitters are conjugated polymers cp or anionic transition metal complex itmc however they still encounter serious hitches with respect to selfstability and sustainability hence the lec community exercised to find new rainbow emitters among them sms are considered the next generation due to the recent major achievements in nir and white lecs to advance this emerging field potalec aims at developing a fullfledged phosphorescent and tadf sm possibilities of harvesting both 25 of singlet excitons and 75 triplet excitons design to achieve highly performing rainbow lecs based on the smlec and organic light emitting diode oled prior arts this project will focus on two action lines i ionicneutral phosphorescent sms with peripheral bulky groups and covalently linked host moieties to enhance plqys and device efficiency and ii ionicneutral rainbow tadf emitters used as single emitters or hosts optimized monochromatic lecs will be targeted and the best sms will be used in white lecs
next generation highspeed optical networks for metro access

connectivity is the major driver in the modern information society where the range of datadriven applications is exploding and new informationbased value chains are rapidly emerging optical networks are the backbone of the global communication infrastructure interconnecting billions of people and a huge number of various autonomous devices control systems and machines optical systems development incites the skyrocketing growth in the demand for data exchange and harnessing fuelled by webbased services such as ultrahd streaming cloud services 5g proliferation fostering the changes in the digital world and shaping the structure of the modern society the demand growth is especially pronounced in the access and metro links where data rates largely exceeding the current 1 tbs will be required moreover the covid19 with the huge number of people working from home has intensified the pressure on the optical networks also features such as the financial cost of the system elements latency dynamic reconfigurability and energy consumption gain progressively more importance for the new generation of access and metro networksthe doctorate network nestor will answer the how when and where coherent optical transceiver will be deployed in metroaggregation optical networks to meet the demand for new costefficient solutions nestor will also address the who by providing advanced training to 10 fellows from a new generation of engineers with phd projects significantly expanding the flexibility and capacity of accessmetro networks nestor harnesses the complementary expertise of the top academic groups aston polito upc sssa and tue and core telecom industry infinera bt orange smoptics vpi and ericsson nestor will provide fellows with a uniquely broad education ranging from recent advances in mlai to realworld telecom engineering which will enable them to design and implement highcapacity access and metro networks
developing neural crest organoids with inducible neuroblastoma to model chemoresistance in mycn amplification related highrisk cases

neuroblastoma nb is the most common cancer in infants and the 3rd most common cancer in children according to the who 90 of nbs occur in children younger than 5 years old and 15 of all pediatric cancer related death are due to nb approximately 20 of nb cases are characterized by the amplification of the mycn gene which is linked to more aggressive tumors and poor prognosis highrisk nb despite recent treatment advances relapsing highrisk nb often leads to death understanding mechanisms of therapy resistance can help to develop more effective treatment protocols however investigation of acquired resistance upon chemotherapy is largely limited by the number of patients with highrisk nb and the availability of adequate model systems mice models of nb are often used however species specific differences in sympathoblast development might result in misleading findings sympathoblast are the fetal counterparts of nb cancer cells and they are derived from the neural crest ncthe overall aim of the neuroblastorg project is to establish a human organoid model of the nc lineage which can recapitulate human specific embryonic developmental stages while also giving rise to sympathoblastlike nb cells in addition to healthy sympathoadrenergic lineage derivatives nb organoid to reach this aim human induced pluripotent stem cell lines will be genetically modified to overexpress the mycn gene under the control of an ncspecific promoter but only in a subset of nc cells within the organoids relevance of the established model will be validated by comparing gene expression signatures between nb organoids and human nb patient tumour samplesthe nb organoid model system will provide a platform to simulate treatment of nb cells with nbtherapy relevant agents and monitor the effect of the applied treatment allowing the investigation of human nbspecific chemoresistance acquisition in mycn amplification related highrisk cases
inerterbased vibrating barrier for seismic protection of a cluster of building structures

earthquakes are one of the deadliest and costliest natural hazards in europe earthquakes have been responsible for more than 200000 deaths and damage worth at least 250 billion euros during the 20th century in italy alone more than 400 destructive earthquakes have been documented in more recent history the central italy earthquake in 2016 killed 297 people and caused damage worth at least 4 billion euros vibrationclear proposes the use of inerterbased vibrating barrier iviba for earthquake protection of a cluster of building structures the iviba is unique because unlike any other currently available earthquake protection technologies the iviba is buried in the ground and tuned to protect surrounding structures without being directly in contact to them through a structuresoilstructure interaction sssi mechanism the iviba can be a solution for a lowcost seismic protection technology for existing buildings as one iviba can be designed to protect many surrounded structures something that has never been explored before aiming to address the apparent gap this vibrationclear project sets two key objectives a propose a novel iviba and its optimisation method and b perform 2d and 3d numerical finite element simulations considering a more realistic environment multiple iviba with a cluster of building structures using both analytical and numerical methods the iviba will be accurately designed modelled and simulated using finite element software with various types of earthquake ground motionswith the support of my supervisor prof marco domaneschi at the politecnico di torino the fellowship will train me in earthquake engineering and structural dynamics and act as a pilot for my own erc starting grant on seismic protection technology ultimately the project seeks to provide lowcost seismic protection technology for buildings to protect people from earthquakes
primordial germ cells environmentallydriven fate in zebrafish

in a global climate change scenario with pieces of evidence of abiotic factor changes and the increase of pollutants due to anthropogenic activities we are starting to accumulate evidence of its effects on animal welfare and physiology one of these effects is changes in fish sex determination and differentiation processes due to alterations of abiotic and anthropogenic factors among these factors temperature is known to affect sex determination well before the gonads are differentiated pointing towards an evident interplay between the genetic and environmental factors even prior to gonad formation at the primordial germ cell pgcs stage however how temperature controls pgcs and final sex ratios fate is still unknown in this project i aim to dissect when and how temperature is controlling the fate of pgcs hence driving the future sex ratio of the population since changes in sex ratios could put at risk future food production and species conservation to that extent i propose combining stateoftheart imaging genomic and epigenetic technologies to analyse pgcs transcriptomic and epigenetic landscapes of zebrafish under thermal stress this project capitalises on combining my background in epigenetics and bioinformatic fields with extensive expertise in developmental biology fish sex determination and differentiation and spatial transcriptomics of the host labs this multidisciplinary proposal will explain how temperature increases as predicted on a climate change scenario modulates pgcs fate and identity these results will significantly advance the field of epigenetics and developmental biology and will impact future food production and species conservation finally the knowledge and skills gained from this project will allow me to become an independent researcher and hopefully enable me to establish my own line of research in regulatory genomics applied to aquaculture and marine conservation
innovative methodologies for the design of zeroemission and costeffective buildings enhanced by artificial intelligence

zebai is an ambitious integrative project in which a broad range of interdisciplinary teams collaborate to develop a new methodology that aims to change the way that zeroemission buildings are designed by integrating all interdependent analysis and partial alternative decisionmaking processes under a holistic approach that allows the evaluation of a design simultaneously taking into account energy performance environmental impact indoor environmental quality and costeffectiveness for this purpose we will require to develop a database of wellcharacterised materials and make an estimation of discrepancies between simulated and actual building performance the methodology that will be used is artificial intelligence techniques to optimise the selection of materials and systems in different aspects of the building design the aiassisted methodology aims to make the design process more efficient and userfriendly while incorporating all environmental quality and costeffectiveness objectives this approach will enable the optimisation of new architectural designs towards scalable zero energy building zeb design in different climates usages and building patterns with the ultimate goal of achieving a zeroemission building stock by 2050 during the project we will test zebai methodology with four representative demonstrators located in ukraine spain the united kingdom and the netherlands zebai relies on previously funded european research projects and aligns with several national initiatives in which the partners collaborate
black hole horizons in quantum gravity

the project black hole horizons in quantum gravity aims for an indepth investigation of black holes and the information paradox in the context of quantum gravity due to the recent breakthroughs in astronomy these exotic objects have moved from the purely theoretical realm to being abundant in our physical universe surprisingly our theoretical understanding of them is insufficient to even in principle understand their horizons and what happens behind them our approach to tackle these questions is to combine a lowerdimensional approach with holography as a guide within this framework substantial breakthroughs were made in the sachdevyekitaev models and their lowenergy gravitational description in terms of jackiwteitelboim gravity this model is exactly solvable to a large degree and many important lessons on black hole physics and quantum gravity can be studied quantitatively and exactly our goals within this project span across two lines firstly we will apply quantum gravitational results on the jackiwteitelboim gravity model to address aspects of the black hole information puzzle in a quantitative way and probe the deep questions on black hole horizons largely building on our detailed knowledge of this model in particular we will calculate correlation functions of local infalling bulk observables and assess the effect of quantum gravitational corrections to evaporation secondly it is vital to investigate the universality of the set of techniques and methods we use in jackiwteitelboim gravity we will do this by pursuing several roads simultaneously dilaton gravity models 2d string theory the original sachdevyekitaev model supersymmetric models and 3d pure gravity armed with these results we will extrapolate to higher dimension and in particular to our physical universe making contact with the first objective
cityoriented impacts of regional climate for europe

extreme weather events are already affecting urban areas with sometimes severe impacts on people infrastructure and socioeconomic activities faced with these effects which are expected to increase due to climate change decisionmakers need sound climate information on local urban issues in order to better plan the cities of tomorrowtoday climate change impacts on urban areas are assessed by separate scientific communities with some methodological limitations for each approach regional climate models rcm provide climate change information at the regional scale but with a coarse horizontal resolution for cities and without specific surface parameterisation for urban processes most highresolution impact studies focusing on urban issues energy thermal comfort do not take into account urbanregional climate interactions and are city and indicator dependentthe circe project aims to develop a more robust and generic methodology for assessing the impacts of climate change on european cities by 1 identifying innovative impact indicators that are relevant for local decisionmakers and can be calculated from modelled and available city data and 2 clarifying the best current regional climate modelling configurations for urban impact studies to this end the new generation of highresolution convectivepermitting models cpm will be used for the first time in a multicity ensemble approach multisectoral indicators will be defined based on local climate risks with a focus on heat waves and extreme precipitation and urban issues related to various european cities the ability of climate models to simulate specific extreme climate events and their impacts on cities will be assessed then their future evolution will be analysed by combining the largest set of rcms and cpms currently available the final objective will be to codevelop an urban climate service demonstrator based on these results and to feed into the cordex flagship pilot study urbrcc
craft revitalization action for futureproofing the transition to innovative technologies for sustainable development

craftit4sd craftit4sd craft revitalization action for futureproofing the transition to innovative technologies for sustainable development aims to activate the ccsi towards the green transition by building on the rich cultural heritage and strong creative traditions which underpin the european ccsi it is the ambition of craftit4sd to revitalize knowledge practices and traditional techniques as shared cultural resources for sustainability as well as spillovers into a new customer driven and sustainable creative economy allowing for bornsustainable small and microsized enterprises to share climate impact data and flourish via an open source and open data platform craftit4sd explores crosssectoral ccsi innovation through a new ecosystem approach and with four pilot clusters dk es fi ro where regional governance public private partnerships entrepreneurial living labs learning communities and consumerengagement approaches support shared experimentation towards the green transition craftit4sd goes beyond the state of art by merging otherwise often siloed cci sectors to further articulate a holistic approach bridging past present and future design and production opportunities in the sense that craftit4sd combines techniques skills and materials associated with traditional crafts with emerging possibilities for integration with new digital technologies and data analytics processes and services and adopts a new ecosystem approach to facilitate cocreation between traditional craft stakeholders the fashion industry smes by designers artisans artists through immersive media technologies craftit4sd holds the ambition to replicate insights learnings and tangible results leading to a ccsi driven green transition informed by the eit climate kic and inspired by the new european bauhaus in other ccsi ecosystems and thus to contribute to the eit culture and creativity kic across its colocation centers
systemic delivery of oncolytic herpes simplex viruses retargeted to cancerspecific receptors virus optimization and business planning

solid tumors in particular metastatic ones represent unmet clinical needs and the second cause of death worldwide oncolytic viruses ovs kill tumors and spare normal cells they are a distinct class of novel anticancer agents frequently administered by intratumoral injection a holy grail in the innovation of ovs is the possibility to administer them by systemic eg intravenous injection so that in the human body ovs search for metastases and scavenge them the systemic delivery of ovs tackles societal challenges as it meets the needs of metastatic patients those who die of cancer and need innovative therapies most the principal investigator has generated a family of innovative oncolytic herpesviruses rehvs which specifically target her2positive tumors her2rehvs in preclinical studies her2rehvs exhibit high specificity for her2positive cancers high antitumor efficacy also against metastatic tumors vaccinate against metastaticlike tumors and are highly safe these properties position rehvs for systemic delivery the rehv technology is protected by a portfolio of patents the objectives of this proposal are twofold firstly to improve the systemic delivery of rehvs by identifying the obstacles that constrain such administration to develop novel strategies to overcome them including highrisk highgain modifications that make rehvs better suited for the systemic delivery secondly to carry out initiatives for the technological transfer ie development and commercialization of rehvs these include the detailed planning of activities to take rehvs to the authorization for a firstinhuman clinical experimentation to develop a business plan and carry out ov market analysis and search for investors by combining the development and commercialization initiatives with the technological advancements this poc is expected to achieve the broader objective of progressing rehvs into clinical experimentation and ultimately to bring them to patients