Dragon09/odtu_chatbot huggingface dataset:
harnessing the sun structural elucidation of the photoprotective photosystem ii interactome

splitting of water molecules by photosystem ii psii in oxygenic photosynthetic organisms sustains oxygen evolution on earth making this complex central for life on this planet sunlight is arguably the most variable source of energy in natural environments with variations in quantity and quality occurring in the range of seconds to hours and photosynthetic organisms evolved an ensemble of photosynthetic mechanisms to thrive in every ecosystem consequently the ecological success of photosynthesis relies on the interaction of a conserved psii catalytic core with a plethora of interacting proteins its interactome to optimize light harvesting and drive the disassemblerepair cycle of excess lightdamaged psii the structural association of psii with its interactome is inevitably transient and therefore recalcitrant to classic approaches for structural determination photolink will employ a novel multidisciplinary approach that combines structural proteomics spectroscopy and cryoelectron microscopy em to provide a complete picture of how photosynthetic organisms adapt their psii interactome to everchanging environmental conditions the methodological approach will be developed initially using two ecologically divergent model organisms the vascular plant arabidopsis thaliana at and marine phytoplanktonic diatom phaeodactylum tricornutum pt the subsequent structural elucidation of the photoprotective mechanisms in the organism of choice will provide cuttingedge scientific knowledge along with valuable directions for biotechnological improvement of lightuseefficiency in globally relevant crops to increase their productivity thanks to data acquired in at andor to optimise co2 sequestration and transformation in marine phytoplankton thanks to data acquired in pt
highthroughput oligonucleotide synthesis and ngs for digital text storage and retrieval in dna encapsulated nanofibers

incorporating biomolecules as integral parts of computational systems represents a frontier challenge in bio and nanotechnology using dna to store digital data is an attractive alternative to conventional information technologies due to its high information density and long lifetime however developing an adequate dna storage medium remains a significant challenge in permitting the safe archival and retrieval of oligonucleotidestextadna introduces polymer fibres as a novel approach to encapsulating and retrieving informationcarrying oligonucleotides we will develop a complete dna storage workflow encoding digital information into dna base sequences and optimising oligonucleotide synthesis and encapsulation in polymer nano and microfibres the project is led by nanogune a nanotechnology research centre and partners with eurofins a leading european company specialising in stateofart oligo synthesis and nextgeneration sequencing we will design nextgeneration sequencing assays to automate the dna digital storage readout retrieved from fibres the enhanced oligo synthesis and sequencing strategies that textadna will develop are of fundamental interest in the path toward broader use of dna digital storage increasing synthesis speed and length of oligos and reducing costs the consortium will create the conditions for encapsulating oligonucleotides inside polymer fibres and methods to retrieve them we will establish efficient methods of synthesising oligonucleotides going beyond stateofart phosphorodiamidate chemistry while ensuring their stability further textadna will also explore ways of incorporating sequencing technologies into reading digital data stored in oligonucleotide pools and expand the data storage capabilities of dnatextadna will add to the european leadership in dna data digital storage by leveraging oligo synthesis and sequencing with nanotechnology to build dna digital storage materials
detection of pedestrians and cyclist outside a line of sight

the number of road accidents continue to increase dramatically each year cyclists and pedestrians being a part of the daily traffic keep challenging drivers thus making safety issues increasingly important furthermore miniature electrical vehicles paving their way through traffic and being in many cases unseen by drivers put themselves in danger improving driving safety being always a subject to technological efforts is one of the most important challenges of the modern society continuously developing technologies offer a broad range of tools capable to assist a driver in a decision making moreover autonomous vehicles nevertheless facing a broad range of challenges nowadays will certainly sooner or later contribute to the endeavor optical camera solutions lidars and highfrequency radars are already demonstrating exceptional assistance in driving safety by providing overlapping and complementary data however all existent safety systems require having an unperturbed line of sight to obstacles this is a severe limitation which cause those systems to overlook numerous dangerous events including pedestrians stepping on a road from behind a parked vehicle and many others mhz and lower ghz frequencies are known to penetrate material bodies and diffract around obstacles eg we have a wifi signal in office nevertheless the router is placed behind a wall in a corridor however low frequency waves are never used in automotive applications owing to low range and angular resolutions they can grant as it is commonly believed while this statement is almost a ground truth in the field it can be bypassed if a preliminary information on an object does exist this includes and not limited to rotating bicycle wheels human breath and several others here we will develop a lowfrequency radar for detecting cyclist and pedestrians with a resolution sufficient to ensure a road safety and assisting drivers to make right decisions
chiral light emitting diodes based in photonic architectures

radiant chiral light emitting diodes based in photonic architectures is an innovative research endeavor with a transformative mission the production of highperforming and costefficient chiral leds lightemitting diodes that harness the optical properties of scalable chiral metasurfaces operating seamlessly across the visible to nearinfrared spectrum with a multifaceted approach the project seeks to endow with chirality three distinct technologies organic light emitting diodes oleds perovskite leds peleds and quantum dot leds qdotleds promising exceptionally bright output and remarkable degrees of circular polarization these chiral leds find diverse applications in fields such as display technology communications sensing and advanced lighting systems promising to revolutionize various industries with their enhanced optical properties and broad spectral range leveraging the unique chiroptical response of chiral metasurfaces radiant precisely modulates high photoluminescence quantum yield plqy emitters including perovskite nanocrystals quantum dots and organic semiconductors using advanced nanophotonic architectures that interact with light through optical resonances thereby enhancing and modulating the light emission at the core of the project lies a novel scalable and low carbon footprint soft nanoimprinting imprinting process that enables seamless integration of photonic nanostructures across different led technologies in a broad spectral range radiant unlocks the potential of nanophotonics for optoelectronic technologies through costeffective and scalable chiral metasurfaces produced via soft nanoimprinting lithography while reducing the dependency on critical raw materials currently used in advanced leds radiant promises to revolutionize the billionaire led landscape market combining technological innovation economic viability and environmental sustainability
acceleration of the worlds first autotaxin inhibitor for the treatment of pancreatic cancer pdac

ionctura is a clinical stage biopharmaceutical company dedicated to delivering innovative cancer treatments to patents with unmet medical needs ioncturas unique pipeline of drugs unlock mechanisms at the tumourstromaimmune tsi interface a multi cellnetwork that is responsible for driving tumour growth and survival as well as treatment resistancepancreatic cancer is one of the most lethal cancers associated with devastating impact on the quality of life of patients current treatments are largely ineffective and there is a need for gamechanging therapies ioa289 is a first in class autotaxin atx inhibitor that tackles cancer growth and spread by affecting core mechanisms at the tsi interfacethe eic accelerator funding for curepdac will allow ionctura to accelerate the clinical development of ioa289 as a treatment for pancreatic cancer through phase iii clinical trials reach a major value inflection point and attract further financial investment into the company
the genetic basis of host resistance and pathogen virulence in the septoriawheat pathosystem

increasing agricultural sustainability has become more than ever a priority in this sense wheat plays a central role in eu agriculture as a major crop and controlling yield losses due to diseases can be a serious bottleneck for agricultural sustainability septoria tritici blotch stb caused by zymoseptoria tritici is a globally occurring fungal disease that causes severe yield losses on wheat and is the source of a massive fungicide applications in the eu furthermore z tritici populations evolve rapidly and their adaptation to the proposed control measures monogenic resistance fungicides is a wellknown phenomenon thus breeding polygenic stbresistant varieties is timely and represent the most durable and economic way to limit disease epidemics and reduce fungicide dependecy however this cannot be achieved without a thorough understanding of hostpathogen interactions and an extensive knowledge of 1 host resistances and their effectiveness in pathogen populations 2 pathogen virulence factors and mechanisms of overcoming host resistance the research proposed here the genetic basis of host resistance and pathogen virulence in the septoriawheat pathosystem septowheat aims to address these gaps by using stateoftheart genomics and genetic resources to meet the challenges of stb resistance breeding and pathogens rapid adaptation the project will be articulated in three integrated objectives 1 genetic mapping of novel resistance locigenes from diverse tetraploid wheats 2 identification of the corresponding pathogen avirulence genes and 3 development of diagnostic molecular assays to accelerate resistance introgression into elite prebreeding material septowheat will have numerous outcomes on durable stb resistance reducing fungicide use within the eu and will significantly contribute to our understanding of hostpathogen genetic in an important agricultural system
fair data and innovative services for magnifying the climate adaptation potential of european communities

adaptation to climate change has become a central focus for researchers across various fields including climate science environmental science urban planning information science and social science to support policymakers in making informed decisions to build a climateprepared and resilient society the major challenges in achieving this goal are i lack of seamless interaction between platforms data spaces and users ii poor data interoperability as well as service interoperability iii lack of infrastructural support for generating fair data and iv legal barriers hindering access to data climateadapt4eosc aims to overcome these challenges by providing an eosccentred collaborative research environment equipped with existing eosc data and services and extended with new data and services such as interoperability fairification research results publishing as open data data adaptation data format compliancy mapping and entity matching enabling interoperability and seamless interaction of data that allow the creation of extended services eg big data analytics for climate risk assessments the project develops a climate change adaption ontology and an eosc climateadapt knowledge graph based on the ontology supporting findability accessibility tracking and life cycle management of research outputs of various kinds including data scientific papers methods code software packages and tools climateadapt4eosc also develops three innovative services that provides support to eu mission climate change adaptation and the european green deal these services have been planned to be demonstrated in five eu countries
a social demography of widowhood across ageing societies

widowhood is a critical event entailing profound grief although the frequency of this high risk event is increasing across ageing societies many countries have cut survival benefits exposing more bereaved spouses to dire short and longterm consequences despite its growing relevance widowhood research remains underdeveloped compared to other disruptive events such as divorce this groundbreaking research moves beyond the stateoftheart in at least four ways to establish a social demography of widowhood 1 the foundation of my project lies in an innovative conceptual and methodological approach to the risk and vulnerability to widowhood while risk aims at the probability and duration of widowhood vulnerability focuses on its mental health and economic consequences current assessments of widowhood effects are limited to change in wellbeing directly after bereavement with a special focus on unexpected deaths however the most prevalent scenario entails a process of terminal health decline in the years before death the consequences of the often neglected longer process of expected widowhood may be larger than the shorter process of unexpected widowhood three groundbreaking pillars build on risk and vulnerability to examine 2 social inequalities by socioeconomic status raceethnicity and nativity social support networks gender and age as well as 3 country differences and 4 change over time highquality crosssectional and longitudinal data sources will be harmonized and applied to an advanced set of statistical methods for up to 60 ageing countries varying in demographic trends and welfare systems from 1985 with projections to 2050 a social demography of widowhood will supplement fragmented evidence with systematic and comprehensive estimates on risk and vulnerability provide insights into the challenges facing a growing widowed population and their family members and facilitate new research on sustainable pension and elder care systems
artificial scientific discovery of advanced quantum hardware with highperformance simulators

the experimental capabilities to generate control and measure complex quantum systems have dramatically improved over the last few years with ingenious proposals for practical applications a powerful new paradigm of technology emerges that exploits quantum superposition and quantum entanglement as these systems get more advanced designing new quantum experiments and hardware becomes ever more intricate for human scientists to exploit the full potential of quantum physics researchers have started to involve artificial intelligence in the automated design of quantum experiments unfortunately even the currently most powerful methodologies have severe limitations and therefore cannot cope with the enormous potential that quantum mechanics promises us for that reason in artdisq i propose to build highperformance physical simulators which are at the heart of all aidriven discovery and design efforts the key idea is to use a framework originally developed for the efficient training and execution of large neural networks called jax jax is powerful enough to encode not only neural networks but a wide range of computer algorithms it allows for modern highperformance computational techniques such as justintime compilation autodifferentiation and direct access to the gpu in artdisq i will exploit this dramatic acceleration which will open previously unchartered applications including aidriven 1 design of highly sensitive and robust quantumenhanced gravitational wave detectors2 design of new quantum techniques for imaging systems with a focus on optical telescopes3 hardwaresoftware codesign for quantum hardware with the potential of discovering highly unorthodox and exotic solutions with superior behaviour as such artdisq aims to develop a revolutionary way to augment human researchers ingenuity and creativity to accelerate scientific discoveries
development and validation of directfed microbials for farm animals to improve animal growth and better nourish the planet

in 2021 the worldwide population was approximately 8b and it is expected to grow at 1 annually over the past 70 years the agriculture industry has made significant efforts to increase livestock production and improve food security but the results are neither sustainable nor sufficient for current food needs aviwell has developed innovative direct fed microbials dfm with the ability to control livestock body weight and energy metabolism targeting specific phenotypes with greater efficiency and efficacy these dfms are diverse native natural and are only fed as a single dose in the early life of the animal also aviwell has created a newconcept hybrid aibased discovery platform that quickly and efficiently identifies powerful multistrain bacterial consortia networks constantly improving and extending our dfm product portfolio aviwell needs the eic funds for the completion and the optimization of both the platform and dfm products and its marketapproval and entry
turbulenceonachip supercritically overcoming the energy frontier in microfluidics

the technological opportunities enabled by understanding and controlling the microscale world have not yet been capitalized to disruptively improve energy processes especially heat transfer and power generation this is mainly due to the laminar flows typically encountered in microdevices resulting in low mixing and transfer rates this is a central unsolved problem in the thermalfluid sciences in what some researchers refer to as labonachip and energy the microfluidic frontier therefore the overarching goal of the scramble project is to overcome this longstanding frontier by i discovering the fundamentals of inducing turbulent flow in microchips by means of utilizing highpressure supercritical fluids ii finding the critical conditions to drastically enhance and control mixing and transfer processes and iii designing fabricating and testing a disruptive firstever series of turbulenceonachip prototypes for transferring energy with a hundredfold performance improvement with respect to standard microsystemsachieving microconfined turbulence has deep scientific and engineering implications for disruptively advancing microfluidicintensive applications like for example in chemistry and biomedicine and to open a new research avenue to develop and apply groundbreaking turbulent flow solutions to microfluidic energy conversion and power generation technologies these consume an aggregated 70 of the european unions energy in the medium to longterm future the technology proposed could enable i the efficient miniaturization of thermodynamic cycles for power generation ii reconceptualization of the nextgeneration of computer processors based on remarkably powerful microfluidicbased cooling and iii the adoption of novel microfluidic solutions in fuel cells for transportation and propulsion these advances together with many other potential breakthroughs could help drive the transition toward a greener energy economy
3d printing fabrication of tailored interfaces for pressurized protonic ceramic electrolysis cells

pressuriz3d aims to advance in the field of pressurized protonic ceramic electrolysis cells pcec with the utilization of advanced fabrication techniques such as maskedstereolithography msla and robocasting aiming to reduce the utilization of fossil fuels on a global scale the design of systems for hydrogen production via steam electrolysis is fundamental to increase the reliability of renewable energy sources pcecs are hightemperature electrolysers which use ceramic electrolytes characterized by high protonic conductivity compared with other htes eg solid oxide electrolysis cells soec this type of conduction mechanism can significantly reduce the operating temperature of the device eg from 700900 c to 300650 c respectively for soec and pcec additionally pcecs can produce directly pure hydrogen eliminating the purification process to remove steam necessary for soecsfabrication of a pcec via additive manufacturing am techniques can significantly reduce production costs and the waste of material during processing thus boosting sustainability and circularity aspects complexshaped electrolyte can be produced increasing the mechanical resistance with the joining materials to maintain the gas tightness of the system ie glassceramic sealants patterned surfaces coupled with glass ceramic sealants will allow the utilization of pressurized gases which are expected to significantly increase pcec performances furthermore geometry modification of the electrolyte membranes thanks to the fabrication via msla printing can further improve the performance and the hydrogen production rate a high impact on the future career of the candidate is expected by complementing his current background with new skills in the field of hydrogen conversion in particular the design and processing of pcec and the integration of glassceramic sealants for the fabrication of pressurized systems
pragmatic approach to adoptive cell therapy act using tumor infiltrating lymphocytes til in selected solid tumors

the pragmatil trial aims to optimize treatment of cancer patients with tumourinfiltrating lymphocytes adoptive cell therapy tilact and substantially expand and improve the clinical implementation of this treatment modality in academic hospitals to this end treatment related toxicities associated to highdose interleukin 2 hdil2 required for expansion and activation of tils will be reduced while maintaining efficacy this improved tolerability will achieve a better clinical management of patients and enhance their quality of life both of which represent major barriers for applying this treatment the objectives of pragmatil are i to determine whether tilact using il2 analog anv419 reduces the frequency of grade 24 studyrelated nonhematological toxicities