Dragon09/odtu_chatbot huggingface dataset:
stable and clean iron power from iconic

iron power is a new technology to store and transport sustainable energy an iron aerosol mixture is burned in a flame and the heat is used in high temperature processes the formed ironoxide powder is collected and transported to places with a surplus of green hydrogen where it is regenerated back to iron powder as such iron power is a very promising co2free circular energy carrier of sustainable energy which has a very high energy density is easy to handle safe environmentally friendly and cheap within the fast growing iron power community existing solid fuel combustion concepts are applied mostly but these show severe problems caused by the specific character of iron aerosol flames a flame stabilisation is difficult to establish b nanoparticles and c high nox emissions are also difficult to circumvent a completely new combustion concept is needed to solve the problems the erc program metalfuel creates the basic knowledge on metal aerosol combustion with the right ingredients to do solve these problems the combustion concept developed is called iconic ignition controlled lownox iron combustion within this erc poc a wellcontrollable iconic burner will be developed designed tested and patented a smallscale system will be developed and studied first after which a conceptual design of megawatt size will be developed which will enable future implementation in an industrialscale system furthermore the possible future market will be evaluated a startup is already interested and a launching customer seems to be in view if the poc is successful
an anaerobic native approach to shine light on c1cycling biochemistry using environmental microbial biomass

microorganisms have shaped the earths biogeochemistry for almost 4 billion years among them anaerobic archaea dominate the carbon oneunit cycle nourish ecosystems and orchestrate the final step of organic matter degradation they remain mainly uncharacterised and uncultured while harbouring a universe of concealed enzymatic chemistry which cannot be approached via classic omics enlighten will study these nonisolated archaea as part of the microbial dark matter by exploiting native biomass rather than artificial systems the overall carbonprocessing catabolic landscape will be pictured through an anaerobic pipeline simultaneously investigating multiple enzymes bound to physiological partners and equipped with native metallocofactors this approach proved its success by deciphering the first and last steps of the ethaneoxidation process from an anaerobic microbial enrichment breaking the accepted metabolic model of archaeal alkanotrophyenlighten will develop into three branches i we will pioneer the biochemical investigations of enzymes from methanotrophic archaea enrichments ii the native catabolic machinery from acetatedegrading methanogens the prime methane producers in the world will be isolated from mesocosms iii as the most challenging project we will study marine environmental enzymes from sediments and microbial mats conducting anaerobic methanotrophy and methanogenesis catabolic enzymes are naturally in high abundance in these multiple subspecies communities single protein populations will be sorted out by chromatography and ultimately by crystallisation and studied by a suite of biophysical biochemical and structural technics as we recently did for a methanegenerating enzyme isolated from a wastewater treatment plantenlighten will open a field to characterise the functional dark matter which can be further applied to other metabolisms and offer an unprecedented view of the molecular tricks used by the microbial world
the science for stronger societies sciencefuture

scincefuture is a collaborative initiative that seeks to blend scientific research on climate change and natural disasters conducted by leading universities sakarya university kocaeli university and düzce university with the involvement of local authorities sakarya governorship and various participating organizations from three neighboring provinces all while engaging the broader public within the framework of this twoyear project the plan involves the orchestration of educational events such as competitions workshops presentations and science nights each hosted by our project partnersthe goal is to foster a connection between scientists and the general public encouraging young individuals to actively engage in scientific endeavors and pursue careers in these critical fields as a direct outcome of the yearlong activities throughout all these activities the project also aims to disseminate the european unions science policies with a particular focus on climate change and environmental policies to the diverse layers of the local community
dual mnnicatalysed functionalization of unreactive sites of amines

with most bioactive molecules such as pharmaceuticals and agrochemicals being complex amines efficient synthesis and functionalization is of crucial importance although much progress has been achieved conventional strategies especially those targeting the functionalizations of less reactive sites are particularly ineffective the current methods typically require forcing conditions such as strong oxidizing agents and stoichiometric organometallic reagents or the installation of directing groups and nprotected functionalities that jeopardize their utility in practical synthesis to address these limitations herein we propose a new strategy for the direct and efficient functionalization of amine frameworks at their otherwise unreactive sites specifically i will explore the dual mnnicatalytic systems where the unique features of the mn complexes drive the temporary activation of an amine generating a transient reactive imine intermediate which in turn undergoes the functionalization step enabled by the ni complexes attractively the overall transformation employs earthabundant metals and occurs directly in one pot without any stochiometric activating reagents thereby underscoring the high atom economy enabled by multicatalysis the mechanistic studies will be used to untangle catalytic aspects assisting the rational methodology development attractively a range of functionalizations including arylation alkylation olefination and halogenations at different sites can be achieved which will open up innovative routes to industrially important and valueadded chemicals this highly original project combines the strengths of complex systems chemistry with the power of catalysis to address the current limitations of organic synthesis yielding a project of excellent innovative science that will exploit my unique expertise in mn catalysis while providing me extensive training in multicatalysis reaction networks and computations
paneuropean network for neuroscience research infrastructure and strengthening of support capacities

current challenges in european research and innovation ri infrastructure in neuroscience include barriers for collaboration funding gaps undeveloped skills or lack of alignment in ri policies paneris consortium aims to be more effective together by i ensuring access to a wider pool of european talent to neurosciencerelated infrastructure and ii contributing to the alignment of their ri strategies policies and funding programs at institutional regional and national level access to excellent neuroscience infrastructure and resources will be maximised through capacity building tackling key skills and setting a common internationalisation strategy among the participating entities three widening entities and one nonwidening will promote knowledge exchange among earlystage researchers while addressing issues like research administration communication ethics human resources technological transfer or open science among others moreover interaction with key ri networks will not only increase the global proficiency of consortium members but will also contribute to engage with regional and national authorities for the creation of valuable synergies in funding programs and policies overall paneris will consolidate borderless ri strategies in neuroscience contributing to the free flow of knowledge and technology in the european research area
winds and disk structures near and afar

when and how did the multitude of observed exoplanets form the wanda project aims at tackling this central question by investigating the origin of the ringlike and asymmetric structures observed in protoplanetary disks the cradle of planets and pushing such studies to the distant and massive starforming regions the locations that best represent the natal environments of the known exoplanets the wanda team will employ a novel multiwavelength and multitechnique observational approach based on a combination of highresolution spectroscopy spatially resolved integral field spectroscopy and high spatial resolution imaging at nearinfrared and millimeter wavelengths my ongoing large program at the very large telescope vlt together with my vltmuse data and additional data to be acquired will be combined to a number of ongoing large and normal programs on vltsphere and alma the three phd students and two postdocs hired in the wanda team will work on four work packages aimed at answering the following specific questions are large cavities and rings observed in disks related to the presence of substantial winds does the presence of planets in disks leave significant imprint on the accretion of material onto the star how do externally photoevaporating winds impact the properties of disks and how can we detect them how is planet formation in massive starforming regions different than in nearby lowmass regionswanda will push to find a relation between the observed disk structures and the presence of disk winds or planets to guide us to better plan future searches for exoplanets in disks with a better understanding on how to distinguish winds driven by massive nearby stars from those arising from the disk wanda will pave the way to explore massive starforming regions with current and future telescopes such as elt and jwstthe quest to understand our origin in the cosmos will be a significant step closer with the wanda project
deciphering the nanobiophysics of virushost interactions in 3d cellular systems

the current pandemic demonstrates how viruses represent a major threat for human health viral infection is a complex multistep process involving both the virus and the host cell machinery the very first stage consists of landing and binding of the virus followed by host cell entry and then the release of the viral genetic material into the cell entry pathways are largely defined by the preliminary interactions between viruses and their receptors at the cell interface elucidating this complex interplay is a crucial step towards establishing a full picture of the infection process and may lead to the discovery of new antiviral drugs targeting viral entryour current knowledge of virushost interactions mainly relies on the use of cancerous model cell lines cultured in 2d that far from mimic the 3d in vivo conditions of tissue such as cell heterogeneity and complex organization hence there is an urgent need to develop an innovative platform to monitor and quantify the molecular forces and dynamics at play during the entry pathways in such complex environments the ambition of this proposal is to unravel virushost interactions under physiologically relevant 3d conditions by combining singlevirus atomic force microscopy and optical tweezer techniques by means of cellular models of increasing complexity we will decipher the complex relationship between the organization and heterogeneity of epithelium and the early stages of viral infection at the frontiers of nanobiophysics and virology this project will push the limits of advanced nanotechniques to understand the molecular mechanisms of virus entry in unprecedented 3d in vivo conditionsthis project will have strong scientific and medical impacts in virology it will strongly enhance our molecular understanding of virushost interactions in medicine our new methodology will contribute to the identification of new compounds that target viral infection and the innate immune response
legitimate emergencies reconciling liberal rights and democratic authority in times of crisis

this project will perform a realist analysis of emergency politics more specifically it will give a realist account of what states of emergency reveal about the nature of political legitimacy this will be achieved through a mixture of history of political theory critical analysis of competing recent approaches to emergency and an empirical study of the political crisis caused by the covid19 pandemic at present political realists controversially argue that emergency politics expose how liberal theories of legitimacy are excessively divorced from reality their argument however remains underdeveloped in three key respects in the first place they seek to ground their claims in a broadly nietzschean worldview yet they do so in a manner that conspicuously jars with what nietzsche himself writes about situations of emergency second the realist literature fails to critically engage with recent liberal theories of emergency and vice versa finally realists neglect a wealth of relevant literature in jurisprudence which has not yet been brought to bear on the debate in political theory by addressing each of these lacunae this interdisciplinary project will formulate a robust realist theory of emergency one that will then be empirically applied to the states of emergency declared in response to the ongoing covid19 pandemic the results of the project will be published in the form of a monograph
international human exposome network project

the proliferation of exposome research programs and projects has led to a significant increase in research output and to the establishment of new initiatives and infrastructures in europe and globally yet cooperation between initiatives at the eu level and globally is still sporadic and scattered the ihen project aims to establish an international human exposome network ihen with the overall purpose of improving global research and cooperation on the exposome it proposes an ambitious pathway towards the development of a longer term ihen that brings together multisectorial stakeholders globally which is essential for enhancing the impact of future exposome research specific objectives are to 1 design the organisational structure of ihen so that it serves to strengthen cooperation and coordination of exposome research in europe and foster and align cooperation globally including options for longterm governance and financing 2 identify and make available exposome tools metadata and resources at the global scale in a fair toolbox including tool inventories and data catalogues 3 test the fair toolbox via a series of demonstrator projects 4 develop a roadmap for future exposome research and innovation including the formulation of an operational definition of exposome research and an interim research agenda and 5 effectively communicate and disseminate the ihen project results to a wide community of stakeholders and develop an inventory of exposome training opportunities the project will interact in all stages of the work with key stakeholders groups eu and global exposome researchers initiatives and infrastructures eu national and international agencies and organisations funding bodies civil society organisations and industry
nonabelian anyons in programmable lattices

nonabelian anyons are conjectured topological quasiparticles which shatter our understanding of quantum statistics exchanging two such quasiparticles can transform the quantum state in a way that cannot be undone without unwinding the exchange the exotic properties of nonabelian anyons have puzzled researchers for decades and the robustness associated with their statistics makes them an appealing platform for topological quantum computing despite broad research over the past decades nonabelian anyons defy a conclusive experimental observationthe goal of nonabelian is the realization and exploration of nonabelian anyonic quasiparticles we will focus on two paradigmatic systems quasihole excitations in pfaffiantype fractional quantum hall states and majorana edge states in the kitaev chain in each system we will use control on the microscopic level to prepare the manybody ground state as well as to isolate braid and fuse its quasiparticles using local correlations and interferometric observables we will reveal the properties including their fractional charge and their nonabelian statistics the experiments are carried out on a novel type of neutralatom platform it makes use of ultraprecise holographic beam shaping programmable optical tweezer arrays and rapid ground state cooling techniquesby studying the emergence of nonabelian quasiparticles in two complementary systems this project will shed light on an elusive type of quasiparticle from new angles this will lead to fundamental consequences on our understanding of quantum statistics and provide microscopic insights into strongly correlated topological systems in addition our experiments open avenues for topological quantum computing with cold atoms
missions engagement and education for tomorrow

meet missions engagement and education for tomorrow is the proposed european researchers night event and researcher at school programme in milano and lombardy italy for the 2024 and 2025 editions of the night and for the school years 202425 and partly 202526 firmly rooted on a missionoriented approach and bringing together top ri and institutional players in milano area meet has the challenging goal to reduce the gap between research and citizens increasing their sense of trust in science and fostering a participatory approach in which everyone feels involved and benefits from the opportunities offered by scientific citizenship in an inclusive way the project combines a captivating science festival format for the nights targeting the public at large with a twoyears structured programme devoted specifically to the schools during the nights sciencebased entertainment initiatives interactive exhibitions talks and participated moments such as reallife workshops and science matches will involve citizens in a journey to discover that ri could and should be acted and enjoyed by everybody at school meet brings public engagement initiatives and innovative education approaches with researchers firsthand experimenting citizen science with pupils engaging them preferably but not exclusively on the themes of the eu missions the acquisition and recognition by the research community of the role of citizen science as a research methodology will become a lever for an institutional change supported by meet overall meet will permanently work to stimulate proactive scientific citizenship to engage society and schools through different tools and methods in reflecting on grand societal challenges and on how science could shape culture and future habits finally discovering how much impact could be produced by science in peoples daily lives
determining the mechanisms of lipidtargeting antibiotics in intact bacteria

antimicrobial resistance is a major threat to global health to combat this threat new antibiotics with novel binding modes are urgently needed ideal candidates could be lipidtargeting antibiotics ltantibiotics that target special lipids that only exist in bacterial but not in human cell membranes these drugs kill refractory pathogens without detectable resistance this has generated huge interest so far the molecular mechanisms of ltantibiotics have proven elusive due to technical challenges 1 structures of small druglipid complexes in membranes cannot be solved by traditional methods 2 ltantibiotics need to oligomerize to become active and 3 binding modes are strongly affected by cell membrane profiles in consequence it has been impossible to visualize native binding modes and an entire class of potent antibiotics remains poorly understood in pioneering studies on the drug teixobactin my lab recently presented the first quantitative insights into the mechanisms of ltantibiotics in cell membranes strikingly we discovered that teixobactin uses a novel double attack type of antimicrobial action in which teixobactin forms large oligomers that both block the peptidoglycan synthesis and damage bacterial membranes these findings raise new questions about ltantibiotics i propose to establish a comprehensive understanding of ltantibiotics by elucidating their native binding modes in intact bacteria and at several lengthscales to m to this end i will develop solidstate nmr methods isotopelabelling strategies and superresolution microscopy setups with these tools i will elucidate the mechanisms of some of the most promising antibiotics of our time 1 novel drugs from unculturable bacteria and 2 daptomycin a frontline drug whose mechanism has been chased by two generations of scientists this research will outline groundbreaking strategies for determining antibiotic mechanisms and in so doing address a pressing
hyperpolarized magnetic resonance at the pointofcare

hypmet proposes a pioneering research methodology for hyperpolarized magnetic resonance for realtime monitoring of upregulated metabolic pathways in cancer cells and invivo and for body fluid metabolic analyses with the prospect of revolutionizing the medical approach to personalised treatmentsa common analytical method for structural biology medical imaging and chemical analysis is nuclear magnetic resonance nmr which is flexible but intrinsically insensitive even in the most sensitive nmr spectra many endogenous compounds found in blood saliva or urine are currently unresolved hypmet will establish a groundbreaking technology enabling the detection of body fluids metabolites below the current limit of nmr detection m and the realtime monitoring of clinically relevant metabolic pathways incells and invivo it will enable nmr metabolomics analyses at the pointofcare and will be fully compatible with personalised medical treatments it will be compact less than 101030 cm and will not require superconducting magnetsemerging methods eg hyperpolarisation methods hm can boost the nmr signal intensity hypmet will merge two hms to achieve nmr signal enhancements of several thousandfold continuously in the liquid state and at ultralowmagnetic field ulf ie 10 mt for many nuclear isotopes the two hms are overhauser dynamic nuclear polarization odnp and signal amplification by reversible exchange sabre the pi unique expertise spans method development on various hms and development and implementation of a protocol for realtime monitoring of pyruvate to lactate conversions incells and invivo to probe the state of a tumor in realtime success in this multidisciplinary project will pave the way for efficient nmr metabolomics analyses and for better realtime metabolic conversion monitoring directly at the pointofcare in the future the technology could be further reduced in size and become a widespread clinical tool