Dragon09/odtu_chatbot huggingface dataset:
territorial and regional demonstrations of systemic solutions of key value chains and their replication to deploy circular economy

treasource will innovatively circulate currently incinerated exported landfilled or dumped plastic and biobased side and waste streams by deploying systemic circular economy ce solutions the systemic ce solutions will integrate the two main elements of treasource stakeholder engagement demonstrations sedemos and key value chain demonstrations kvcdemos the demos support chosen territory clusters in introducing ce practices to their citizens and businesses to help 1 decouple from use of fossil virgin resources and excess raw material consumption 2 increase resilience selfsufficiency value chain security environment and nature 3 decrease ghg emissions and contribute to achieve climate neutral economies climate change environmental degradation and loss of biodiversity are major global threats that require urgent collaborative actions across industry sectors cities and regions communities and citizens half of total ghg emissions and more than 90 of biodiversity loss come from resource extraction and processing global consumption of materials especially biomass fossil fuels metals and minerals are expected to double by 2060 and annual waste generation is estimated to increase by 70 by 2050 treasource focuses on demonstrating the ce solutions in cities and regions located in the nordics finland sweden norway and denmark and they will be replicated in the baltics estonia latvia lithuania poland and germany of the baltic sea region the combination of the cities and regions will enable large reach and bigger impact and boost the replicability and scalability potential of the ce solutions a common issue of the regions material circulation is low and decentralised material volumes and resulting challenges in feasibility and bottlenecks have been high risk investments due challenges in securing sufficient feedstock quality and quantity however regional strengths lie in ambitious climate and environmental targets
harnessing evidence on adverse drug withdrawal events following deprescribing through the pharmacovigilance system headp

deprescribing reducing or stopping unnecessary or harmful medications is an important strategy to reduce the risk of medication harm a significant and growing challenge for health systems as acknowledged by the world health organization the aim of headp is to establish the current evidence base on adverse drug withdrawal events adwes and explore how this can be enhanced via the pharmacovigilance system headp consists of 4 research objectives to assess the rate of adwes in published trials of deprescribing to examine the incidence of adverse events reporting related to adwes to identify and review all recommendations related to the monitoring detection and reporting of adwes and to investigate healthcare professional patient and policymaker perspectives on the integration of adwe reporting in the pharmacovigilance system the following research approaches will be employed an umbrella review of systematic reviews disproportionality analysis of key pharmacovigilance databases a scoping review of sources of guidance and qualitative semistructured interviews this innovative research will help address the significant gap in our knowledge of adwe occurrence and will stimulate future studies and innovations moreover this fellowship will provide me with valuable scientific protocol development quantitative data analysis relevant to pharmacovigilance data qualitative research methods data management and synthesis skills and transferrable grant writing research communication and supervision and mentoring skills skills it will also provide me with valuable international intersectoral and interdisciplinary experience and allow me to develop leaderships skills the skills and experience i will gain by completing this fellowship in the host organisation rcsi will help me achieve my ultimate career goal to become a leader in pharmacovigilance research and development in academia or a medicines regulatory agency
a new eu framework for an ethical reuse of health data

the eu has recently enhanced the potential of health data in the eu digital market by promoting a number of initiatives and new regulations to facilitate data sharing and reuse among public institutions the forthcoming provisions of the digital strategy corpus of law these in combination with preexisting rules and practices of health data exploitation might sharpen the risks for citizens for example allowing public bodies to exploit big data sets to make detrimental decisions regarding the access of certain patients to health care eg in the case of insurancebased systems in this context academic analysis is urgently needed as well as suggesting a revision of the new regulations to eu policymakers to facilitate responsible data sharing datacom aims at building a new framework to facilitate an ethical secondary use of health data held by public bodies with the aim of improving accountability and enhancing responsible reuse to build it i will develop and test in intersectoral practical environments the innovative concept of ethical commodification the possibility of exploiting personal data in an ethical way for the public good in accordance with the data subjects expectations and needs and taking into account the risks associated with the exploitation of anonymized data sets focusing on 3 member states italy spain and the netherlands in order to reach this objective datacom has a strong interdisciplinary and intersectoral approach bridging law ethics and computer science taking into consideration the needs of the public sector and those of citizens to ensure the successful implementation of these project goals i will conduct my research at the university of turins law department with the guidance of prof ugo pagallo a leading scholar this project will prepare me to become a tenured scholar and obtain advanced funding strengthening my academic profile and allowing me to establish my own research group
polin the political conditions of interoperability in european digital health policies

the polin projects aim is to explore the political condition of interoperability in european digital health policies interoperability refers to the ability of computer systems to work together even if they are created by different business or state organizations interoperability standards are key to the creation of efficient digital health infrastructures in particular at the european level for instance electronic health records are expected to be available everywhere in the european union flowing within a harmonized european health data space if the technical conditions of interoperability have been extensively explored little is known about the political conditions under which various actors pursuing complex agendas may be willing to adopt common standards indeed standard selection in digital health is guided by many different industrial medical political legal and ethical considerations therefore the aim of this project is to explore the political conditions favoring or impeding the adoption of interoperability standards in eu digital health as digital cooperation marks a turning point for the future of eu integration this proposal will contribute to open a new research agenda aiming to explore how the eu is able to govern through project cooperation furthermore interoperability choices reflect highly sensitive and political decisions which are not trivial and are likely to deeply transform the lives of eu citizens this project therefore intends to contribute to the adoption of better inclusive digital health standards this msc fellowship will be key in strengthening my skills in european studies as i will be guided by a renowned expert in european decisionmaking processes prof stephanie novak in addition the host institution ca foscari university will provide me with many opportunities to acquire new transferrable skills and to develop the interdisciplinary aspect of my research
reusable mask patterning

surface patterning is crucial for the progress of key enabling technologies kets such as advanced manufacturing microelectronics nanobiotechnology and photonics the current paradigm in surface patterning is optical projection lithography opl a paradigm designed for highresolution however emerging green technologies like micropatterned photovoltaics pv require high quality patterning at scalethroughput that is hardly attainable by opl economically and sustainably importantly halfpitch resolutions on the tens of mscale are totally acceptable for such applications which does not justify the use of highend opl in these cases opl is unsuited because it relies on disposable masks with extremely high embodied energy while the key asset of opl is the mask it is the component that currently makes it lowthroughput and energymaterial inefficient extensive efforts have been directed to develop maskless strategies but most fall short when it comes to throughput and design flexibility remap envisions a radically new and green surface patterning technique based on the spontaneous formation of reusable magnetic masks such masks are possible using fully adjustable and reversible interactions of magnetorheological electrolytes mre on a substrate and microstructured magnetic fields generated by a permanent array of electromagnets below the substrate by selectively activating each microelectromagnet it is possible to modulate the intensity and shape of the magnetic field hence the mask over space and time this way remap enables highthroughput areaselective additive and subtractive patterning on a surface at room temperature and pressure furthermore the newly devised mres and the tuneable magnetic array developed within remap will pave the way to a plethora of future applications from labonachip biomedicine nmr analysis and smart fluids for robotic space exploration
a new perspective on city logistics concepts theory and models for designing and managing logistics as a service

several social economic and technological trends are coming together to revolutionize the way people products and services are brought together goods are gaining more mobility with drastic implications for cities the current city logistics cl paradigm which does not consider the mobility of goods a public need limits our capacity to understand and respond to the challenges and opportunities brought by this profound change taking a different perspective goodmobility proposes to replace the technobusinesscentric smart thinking with networkcentric wise logistics that takes the public value as the primary goal and envisions setting up a logistics web with the required infrastructure hardware and operating procedures software to establish logistics as a service laas the first objective is to develop public value as a measurement system to assess and guide cl planning and management which will be achieved with an iterative process combining multicriteria decision making sustainability analysis simulation and optimization the second objective is to develop the principles models and tools for laas infrastructure design novel network optimization methods will be developed for designing the hardware of laas to provide orders of magnitude efficiency gains and influence the stakeholder activities to maximize public value the third objective is to develop a theoretical framework and models for the operating procedures of laas introducing the logistics markets to ensure efficiency and reliability and secure public value in matching logistics demand and supply learningbased optimization methods will be developed to manage logistics markets if successful goodmobility will lay the foundations of a new theory of cl with significant scientific and practical implications the novel ideas concepts and methodologies will open up new research perspectives in transport and logistics with farreaching social economic and environmental consequences
functional nanoscaffolds for regenerative medicine

repair or replacement of tissue and organ functions lost due to age disease or damage represents one of the most urgent medical needs of our aging society the nanoremedi consortium will contribute to addressing this fundamentally important issue by using a new and efficient scientific approach relying on the design preparation characterization and validation of conceptually innovative peptidebased functional nanomaterials for regenerative medicine applications specifically nanoremedi will tackle three highly relevant case studies tissue engineered vascular grafts to replace damaged peripheral arteries stemcell based regenerative medicine for bone and cartilage repair and facing with implantation failure this last addressed to overcome bacterial severe infections as an equally important goal the nanoremedi consortium aims to build a worldclass doctoral educational model in the field of nanomaterials applied to regenerative nanomedicine through a strategically designed academiaindustry interplay to this end 6 beneficiaries one associated partner linked to a beneficiary and 12 nonacademic associated partners will join their forces to icreate a highly innovative research network for training a new generation of 13 doctoral candidates dcs with strong employment potential aimed at studying and developing functional nanoscaffolds for regenerative medicine iiestablish a robust structure for longterm research cooperation between a pool of leading universities and enterprises for broadening and strengthening the knowledge and skills of dcs accessing the nanosciencearea from adjacent disciplines such as chemistry material sciences and bioinformatics iiibuilding a solid foundation for longterm european excellence in medical nanotechnology via dissemination of researchtraining outcomes through crossnetwork secondments summer schools workshops and transferable skills modules and of the best practice generated by nanoremedi
metabolic fingerprinting of autism spectrum disorders in breath by mass spectrometry

current diagnosis of individuals suffering from disorders on the autism spectrum is based on behavioural and developmental observations usually in their early life even so there is a significant amount of people having to live with these lifelong disorders that remain undetected and no treatment is provided to them however it is already established that such disorders are associated with metabolic changes there is now a growing amount of evidence suggesting that such metabolicalterations can be detected in samples such as blood or urine taken from children early in their life these routines however can cause significant discomfort to the childthe primary aim of the proposal will involve the use of less invasive sampling techniques such as exhaled breath and exhaled breath condensate for the early diagnosis of metabolic hallmarks of autism spectrum disorders these samples will be analysed using already established chemical analysis techniques for the detection of small metabolic changes in the obtained samples tandem mass spectrometry techniques will be used for the unambiguous identification of these metabolites data analysis tools such as principal component analysis pca and hierarchical clustering will be used to associate these metabolic changes with existing medical records obtained from the patients to establish a potential diagnostic toolthe potential for the rapid detection of these metabolites will be examined through the integration of novel ambient mass spectrometric ionisation methods such as plasma ionisation the ability to selectively ionise specific metabolites associated with autism will be investigated with the aim of generating an early prototype of a rapid screening method for routine use data generated during the initial stage of the work will be used to create a database that will be used for near realtimecharacterisation of the exhaled breath through the analysis of metabolites and volatile organic compounds vocs
advanced strategies for development of sustainable semiconductors for scalable solar cell applications

solarup directly addresses the ever louder call for sustainable energy production the proposed solar energy conversion technology will reduce dependence on critical raw materials and overcome efficiency thresholds to unlock the future of flexible photovoltaic pv solar cells for mass deployment in smart buildings soft robotics wearable electronics and other consumer products our main innovations lie in nanoengineering zinc phosphide zn3p2 for use as an earthabundant direct bandgap semiconductor absorber and combined with a novel device architecture we target cell efficiency enhancements of up to 15 advanced manufacturing techniques such as nanoimprinting and metalorganic vapourphase epitaxy will be explored to open industrially scalable routes to synthesise high quality zn3p2 films moreover our approach will allow reuse of the growth substrate making sustainability another core element of solarups radical vision optimisation of both the absorber structure and device architecture will be achieved through a holistic interplay of firstprinciples calculations and atomic scale structural and electronic characterisation the main outcome of solarup will be the demonstration of an ultrathinfilm pv technology that is scalable costeffective and environmentally sustainable complete with a comprehensive life cycle analysis in this sense our aim is to feed and inspire the development of zn3p2based solar cells towards a market ready technology the project consortium unites six european teams with complementary expertise at the forefront of zn3p2 research device architecture and life cycle analysis who will approach the ambitious challenges from a flexible and interdisciplinary perspective solarup has clear potential to make sciencebased contributions to energy security and highquality job creation while also connecting to industry and boosting the trajectories of earlycareer team members
quantumoriented update to browsers and infrastructures for the pq transition

the exciting frontiers opened by the development of quantum computers qc come at the cost of breaking the foundations of current digital security the research community is working to the definition of postquantum cryptography pqc to counteract this threat however the transition to pqc is delicate and takes time because it impacts many functions algorithms and protocols in apriori unknown cascade of dependencies qubip is conceived to contribute to the eu transition to pqc with the goal of simplifying and making replicable the process by means of recommended practices and counteract postquantum threats as soon as possible qubip focuses on digital infrastructure addressing the 5 main building blocks that use publickey cryptography for security purposes hardware cryptographic libraries operating system communication protocols and applications qubip address all 5 blocks coherently solving all dependency issues that may arise inside each block and among blocks with the final aim to validate at trl6 three infrastructures making use of those blocks in iotbased digital manufacturing internet browsing and software networks environments for telcos use cases the returnofexperience from the three practical exercises is then maximized by developing a migration playbook that will contain the lessons learned and an evaluation of all the technical economic and legal barriers encountered together with the solutions to overcome them to enable the definition of a replicable process suitable to provide structured accompanying and practical guidance to industrial stakeholders the technical activities are corroborated by three supporting activities i evaluation of the capabilities of qcs to assess their implication to primitives algorithms and protocols adopted and contribution to ii standardization efforts addressing transition to pqc processes and iii policy measures addressing technology changes coming from the advent of qc and pqc
embedded ai systems and applications

embedded artificial intelligence ai has emerged as a transformative technology with immense potential to revolutionise various domains spanning from robotics and healthcare to environmental monitoring and the internet of things this doctoral network dn project ant aims to train a network of 15 excellent doctoral candidates dcs by addressing the fundamental challenges of embedded ai and accelerating the development of embedded ai systems and applications through an innovative and interdisciplinary research and training program ant consists of four interconnected work packages wps that encompass different aspects of embedded ai wp1 tackles the challenges in designing lowfootprint standalone embedded ai models under resource constraints and with diverse contexts and evolving environments wp2 goes beyond standalone embedded ai and designs innovative distributed and scalable learning solutions for heterogeneous embedded ai networks under energy and bandwidth constraints wp3 enhances the trustworthiness of embedded ai with explainability robustness security and privacy ant concludes in wp4 with a concerted effort to transfer fundamental research contributions to industryrelevant applications in autonomous robotics underwater iot mobile healthcare and smart farming boosting europes position in the global ai market both from a talent and a technological perspective these interdisciplinary and interdomain research training along with the comprehensive softskills training spanning from presentation skills to intellectual property marketing and economics etc will make ants 15 dcs highly employable in various industries academia or public government bodies and will position the eu at the forefront of the emerging revolution of embedded ai on things
targeting rna with small molecules

rna molecules play key roles in biological processes and diseases an emerging avenue to develop innovative medicines is therefore to design small molecule drugs that bind to rna and affect downstream biological functions however to advance this field of research a new generation of scientists is needed that can further develop and ultimately master the challenging process of drug design applied to rna therefore the targetrna network aims to educate and nurture the next generation of scientists with cuttingedge interdisciplinary skills in the discovery and biological characterization of rna modulators and thus generate fundamental knowledge on what drives affinity and specificity of small molecules binding to rna the objective of targetrna is to develop compounds with antimicrobial activity through their interaction with rna targets and to use these to selectively reshape the human gut microbiome an area with vast implications for medicine training through research activities spanning from computational and medicinal chemistry over structural and molecular biology to microbiology and in vivo models will be supplemented by an innovative training programme in specific and transferable skills for interdisciplinary drug discovery strategies to target rna including fair data principles open science practices as well as responsible development and sustainable implementation of new innovations to achieve the ambitious research and training goals the targetrna network unites leading scientists from 13 academic partners 8 beneficiaries 5 associated and 4 industry partners 1 beneficiary 3 associated based in 9 countries