Dragon09/odtu_chatbot huggingface dataset:
deciphering the molecular mechanism of eleos a conserved immune system across the tree of life

sensing viral infections and mounting a response is crucial for all domains of life many immune mechanisms in higher eukaryotes were thought to be evolutionary innovations but recent research reveals that some components of the innate immune system have evolved from bacterial genes eleos a novel antiviral system in prokaryotes shares similarities with eukaryotic gimaps gtpase immunityassociated proteins yet their evolutionary history and antiviral mechanisms remain unknownecotols objectives are threefold1identify eleos systems study their architecture and determine their distribution in bacteria2explore the molecular mechanism by which bacterial eleos confers resistance against phages3investigate when and how eleos was acquired in eukaryotes assess its distribution and examine the conservation of the mechanism in eukaryoteswe will analyze large genome datasets to trace eleos system evolution across different life domains additionally we will identify phages eleos defends against and the mechanisms by which phages evade this defense biochemical biophysical and structural biology methods will illuminate the molecular mechanisms in bacterial eleos further genomic analysis and experimental methods will answer whether this mechanism is conserved in higher eukaryotesecotol is a multidisciplinary project pioneering comparative immunology between prokaryotes and eukaryotes this innovative concept aims to enhance our understanding of immune systems which is critical for staying ahead of viral threats improving viral infection treatments reducing viral resistance and enhancing global health security
advancing capacity and analytical tools for supporting common agricultural policies post 2027

the common agricultural policy is the european unions flagship policy for supporting the agricultural sector ensuring food security and safeguarding rural development while it is also a key tool for reaching the objectives of the european green deal including the farm to fork and the biodiversity strategy with these policy strategies the eu aims for more sustainable food systems effectively supporting the policy impact assessment in this new context is a great challenge for the existing quantitative modelling tools as it requires them to substantially enhance the thematic coverage to comprehensively address all the components of the european green deal and ensure consistency with the monitoring systems in place act4cap27 responses to this challenge by enhancing the analytical capacity of the key policy tools capriglobiommagnetagmemod used by the european commission to assess shortterm and longterm policy impacts on eus agrifood systems and providing evidencebased knowledge supporting analysis for the design of agrifood policies post 2027 act4cap27 develops a consistent interdisciplinary methodological framework to operationalise and quantify relevant aspects of the eu agrifood system and related policies post 2027 and their economic social including health environmental and climate sustainability impacts act4cap27 addresses the main shortcomings of current modelling tools with its act4cap27 modular toolbox for eu food system modelling which provides a basis for innovation by creating a collaborative space and a modular model infrastructure for the whole eu agrifood research community and beyond the act4cap27 dissemination and stakeholder platform establishes an appropriate and inclusive engagement with stakeholders to cocreate communicate and disseminate act4cap27 research results act4cap27 launches an interactive roadmap for guiding eu national and regional policy makers weigh up policy objectives towards more sustainable outcomes
exposing hidden targets of drug resistance in cancer by mapping the epitranscriptome at singlecell resolution

drug resistance is one of the biggest challenges in the clinical management of breast cancer bc but the underlying mechanisms are still not fully understood what we do know is that epigenetic mechanisms play a key role in the adaptation of cancer cells to therapy which is why they have become a prime field of investigation singlecell profiling of epigenetic dna and histone modifications have already revealed intriguing and actionable insights into tumor heterogeneity for the most recently discovered epigenetic layer however which consists of rna modifications we have not yet reached singlecell resolution the exciting potential of rna modifications to finetune the processing and expression of mrnas is currently an area of intense research termed epitranscriptomics and the most prevalent and best studied of these mrna modifications n6methyladenosine m6a has recently been linked to drug resistance in cancer our lab has uncovered a new m6abased layer of dysregulation of a major cancer pathway driving therapy resistance in bc the ability to study m6a in single cells holds great promise as it would enable us to further delineate tumor heterogeneity and to find novel drug resistance targets that have eluded us so far i propose to develop a method for streamlined m6a mapping at singlecell resolution aim 1 to apply it to triplenegative bc tnbc cells driven to chemoresistance in cell culture mice and human samples so as to determine uncharted targets of drug resistance aim 2 and to disrupt m6aregulated chemoresistance targets in order to prevent therapy failure aim 3 these aims are aligned with my knowledge and skills related to both m6a and drug resistance this unique and comprehensive analysis of the singlecell m6a methylome will provide invaluable new insights into the unknown epigenetic characteristics of chemoresistance and will pave the way for new therapeutic interventions
a singlecell atlas of human soft tissue sarcoma ecosystems with focus on mechanisms of immune evasion

soft tissue sarcomas sts are rare aggressive cancers about 50 of patients with highrisk sts die within 5 years after diagnosis highlighting the need for novel treatment approaches a major obstacle for novel treatment design is our limited understanding of sts as ecosystems shaped by diverse tumor cells and their interactions with cells of the microenvironment emerging strategies that target cellular relationships in sts are promising such as immune checkpoint inhibition first clinical trials assessing immune checkpoint inhibition were promising but success varied greatly among different sts subtypes and a rational selection of patients was not available a comprehensive description of the complex cellular diversity and interactions in sts tumor ecosystems and links to disease progression are currently missing here we will combine simultaneous detection of singlecell transcriptomes and cell surface proteins with 32plex immunofluorescence imaging to characterize sts tumor and immune cell diversity with singlecell spatial resolution in seven sts subtypes the sts subtypes include dedifferentiated liposarcoma ewing sarcoma myxoidround cell liposarcoma clear cell sarcoma desmoplastic small round cell tumor fibromyxoid sarcoma and solitary fibrous tumor present with poor prognosis and are promising candidates for immunotherapies objectives are 1 to characterize the cellular diversity and tumorimmune interactions in sts ecosystems using simultaneous singlecell transcriptomics and cell surface proteomics 2 to profile the sts immunoenvironment with singlecell spatial resolution in situ and 3 to functionally assess candidate tumorimmune interactions in vitro this project will provide the first singlecell atlas for seven sts subtypes and will enable a better understanding of sts tumor ecosystems pave the way for novel precision oncology approaches and facilitate the identification of candidates for immunotherapy clinical trials
nonlinear analysis for virtual design of composite deployable space booms and membranes

novitas aims to generate novel advances in the mathematical modelling of deployable and ultrathin structures they consist of booms and membranes that are first flat and coiled around a cylinder and then they passively deploy releasing the elastic strain energy stored during the furling phase during history deployable structures were adopted for various space applications for instance for telescopes photovoltaic surfaces and antennas the adoption of deployable booms allows larger structures to be easily and efficiently packaged for launch and reliably deployed on orbit despite the reliability of this kind of structure there are still some issues to be tackled including the development of a mathematical model able to deal with the accurate definition of the multiscale threedimensional stress state and failure identification the material viscoelastic effects the effects of new composite materials and the multibody simulation for the deployment phase we will address these issues with an innovative and interdisciplinary approach that combines theoretical numerical and experimental investigations the mathematical models formulated by novitas will be able to accurately describe the nonlinear mainly geometrical behaviour that this kind of structure typically show during their services whereas current models fall short due to their timeconsuming analyses we will compare and validate the numerical results with those obtained by experiments which consists of the creation of a prototype at the space structures laboratory at caltech for the viscoelastic and thermal multiphysics testing and simulation of deployment phases to be simulated with a multibody approach the developed modelling technique will provide engineers with an efficient way for the design of space structures consistently with the spacebased technological innovation necessary for the always more ambitious needs of our society and to encourage a sustainable european economy
engaging entrepreneurial ecosystems for the youth

ecosys4you designs and implements a crosscountry educational programme for young people with passion for entrepreneurship we mobilise the flow of innovation resources in four dimensions education networking market expansion and people private public and educational actors of three entrepreneurial ecosystems in the ruhr de varna bg and maribor si regions cocreate the programme the activities add value to existing entrepreneurship education of the regional higher education institutions based on our common competence we establish and set up high quality crossecosystem activities for future entrepreneurs the main activities are joint classes mentoring realworld challenges and internships at startups experience of founders and established entrepreneurs drive the programmes design their benefit is the opportunity to enter new markets opened up by ecosys4you the programme is open to students and young alumni from higher education institutions professional schools graduates who wish to found a company and other young people who want to discover entrepreneurial spirit we expect to reach 200 young people among them at least 80 women in 2 cohorts 20242025 and stimulate foundation of about 510 startups and innovations as a major outcome due to close collaboration with lecturers as well as organisational and financial measures designed in ecosys4you we assure a selfsustaining programme to continue after project finalisation
my awesome research is for everyone

marie my awesome research is for everyone is the greek proposal that brings together six of the countrys most prestigious academicresearch organisations to host researchers night events in the years 2022 and 2023 these organisations will hold each year six ern events in four cities of the mainland athens thessaloniki patras larissa and two cities of the island of crete heraklion and rethymnon the events will cover the greek territory from north to south inviting more than 70 of the population to live the european researchers night events before the nights through a carefully designed multichannel awareness campaign marie will spread the ern messages nationwide highlighting the highquality research conducted in europe and its importance for our everyday lives with a mix of traditional and modern marketing tools an extensive network of collaborators and the availability of hundreds of researchers maries ambition is to get into the households of two million citizens inviting them to the nights in addition researchers visit schools and talk to students igniting scientific curiosity and an interest in pursuing a research career furthermore marie organizes the chat lab online meetings of researchers with teachers and students who reside in remote areas providing them with the opportunity to meet researchers and learn about the fascinating world of science during the nights an array of activities mostly led by researchers of different career stages and profiles is foreseen exhibitions with hundreds of technological products handson experiments scientific demonstrations activities designed specifically for kids combined with various entertaining activities will allow visitors to delve into the amazing world of research thanks to the size of the cities the carefully selected venues the thorough awareness campaign and the appealing programme of the nights marie expects to receive more than 24000 visitors at its events
bacterial eavesdropping for fast antibiotic susceptibility testing

antimicrobial resistance amr is a global health problem endangering milliantimicrobial resistance amr is a global health problem endangering millions of lives rapid antimicrobial susceptibility testing ast plays a crucial role in determining the type and concentration of antibiotics required to inhibit the growth of a pathogen however the major issue with the current asts is the slow diagnostics from 24h to a few days leading to misprescriptions andor overprescriptions thus severely impacting treatment outcomes at soundcell we developed soundcell technology a breakthrough technique that reduces the ast time from a few days to less than 1 hour it is a graphenebased biosensor technology that uses nanomechanical vibrations of ultrathin micronsized graphene drums to detect the motion of a single bacterium we demonstrated that motion of alive and dead bacteria are different when adhered to the graphene sensors and we can correlate such changes to antibiotic susceptibility during the eict we will mature soundcell technology into a highthroughput costeffective ast we will develop highvolume manufacturing methods and engineer a userfriendly lowcost prototype readout system we will validate our ast prototype in 2 clinical labs through testing of a variety of pathogenic clinical isolates and benchmarking speed and sensitivity of our platform against other ast techniques we will establish our exploitation strategy and regulatory roadmap develop and execute the business model and develop stakeholders engagement soundcell technology will directly lower healthcare expenses by shortening hospital stays with fewer lab and diagnostics tests and improve clinical outcomes of patients by reducing recovery time secondary complications and mortality we have filed 2 patent applications and envision another 4 patents over the project duration by 2030 we forecast 17m revenues and employment for up to 60 personnel
securing sports education through innovative and inclusive gender equality plans

supporter advances inclusive gender equality within the era it supports institutions to develop intersectional innovative inclusive and impactful gender equality plans 4igeps tailored to sports higher education institutions and explicitly addressing genderbased violence including sexual harassment gbv building on stateof theart knowledge and the expertise of advanced gender equality institutions supporter cocreates an innovative capacitybuilding and mutual learning programme delivering support and mentoring towards the development of the 4igepsguided by inclusive and innovative epistemologies and cocreative methodologies supporter acts horizontally by fostering institutional capacity and culture based on the principles of diversity inclusion within an intersectional framework ultimately enhancing the sports institutions reputation attractiveness inclusiveness and research excellence vertically by triggering a transformative institutional inclusive and sustainable change to sports institutions to address inequalitydriven challenges and advance gender equality focusing on gbv thus also enhancing the institutions efforts towards meeting their gender equality objectives in the era contextto achieve these objectives supporter adopts a twinninginspired approach methodologically based on 3 interlinked processes analytical reflective implementation combining 4i learning and mutual learning schemes with cocreation and dissemination activities engaging a diverse range of stakeholders and building on knowledge and expertise from previous projects and toolsthe multiplier effect of supporter starting from the eight partner institutions and gradually reaching the sports ecosystem has the longterm potential to trigger gender institutional change in a variety of further institutions reaching society more broadly and contributing to widerange systemic societal changes in line with the ljubljana declaration objectives
when your enemy becomes your friend evolution of the interaction between fungi and land plants

plants live in close association with microbes establishing interactions that range from beneficial to detrimental molecular plantmicrobe interactions have been extensively studied in flowering plants whereas research in nonseed plant lineages has been hindered by the lack of pathosystems reflecting natural plantmicrobe interactions my team and i identified the first example of a fungus that establishes opposite interactions with flowering and nonseed plants we discovered that the fungus trichoderma which promotes plant growth defense and stress tolerance in flowering plants is pathogenic for other land plant lineages nonvascular plants and ferns indicating unexpected differences in land plant immunity and fungus behavior the overarching goal of our project frienemies is to decipher the molecular evolution of plantmicrobe interactions from pathogenic to beneficial across land plants in frienemies my team and i will characterize the molecular mechanisms involved in disease in nonseed plants using three genetically tractable nonseed model plants two bryophytes and the cfern and a diversity panel of sequenced trichoderma strains where we will identify fungal effectors plant susceptibility and resistance genes and signaling pathways relevant for pathogenic interactions combining omics reverse genetics natural variation and phylogenetic analyses we will reveal the conservation of susceptibilityresistance mechanisms in other plant lineages and determine the emergence of mutualistic interactions between trichoderma and land plants we envision that frienemies will describe fundamental differences in immunity across land plants discover potentially novel and conserved molecular mechanisms mediating plantmicrobe interactions define their evolutionary trajectories and reveal the key evolutionary switches associated with major innovations in land plants underlying the transition between susceptibility resistance and mutualism
trial platform for 5g evolution crossindustry on large scale

the fifth generation of wireless technology 5g has arrived and is being rolled out globally first industrial sectors such as manufacturing are testing the capabilities of 5g showing great potential for ubiquitous connectivity with the sixth generation 6g wireless communication will bring new features improved performance and functional benefits to several industrial sectorsthe targetx project envisions accelerating the digital transformation of key verticals energy construction automotive and manufacturing using largescale trials in multiple testbeds by demonstrating validating and evaluating the potential of 5g6g in real environments the most advanced 5g6g technologies such as realtime communication localization selfdescription digital twinning and sensornetwork data fusion can be tested and evaluated the focus of the evaluation is on kpis and especially kvis such as sustainability safety security and privacy based on these kvis new business models and a methodological assessment framework for economic and societal evaluation will be developed the development of the solutions will be supported and guided by the targetx community a network of smes it and otpartners and up to 100 fstp third parties bringing together a strong consortium with smes and innovation driversto reach targetxs goals a selection of use cases will be established for all verticals in the existing 5g testbeds new 5g6g features will be developed and integrated into the testbeds and validated in evolved use cases the ftsp projects will both deliver new use cases and technical contributions a large number of ftps participants will strengthen the 5g6g ecosystem results of the project will be discussed with 6gsns projects and used for standardization also in the different verticals
2000 years of subpolar north atlantic circulation

the united nations has expressed concern over the potential weakening of the atlantic meridional overturning circulation amoc in the next century which could cause climate and weather alterations that lead to various socioeconomic stresses especially in agriculture fisheries infrastructure maintenance and social migration the value of information associated with a continuous observational record of the amoc system which enables confident prediction of future trend has been estimated to be tens of billions of euros while instrumental observations of the amoc system are only available for the last decades we must rely on proxy indicators in natural archives to capture the longterm trend of ocean circulation throughout the industrial age and further back in time when there were little anthropogenic carbon emissions such a longterm record is particularly important for the subpolar north atlantic a region of deep convection that maintains the amoc susceptible to freshening as a result of increasing arctic ice melt this project aims to develop the first comprehensive longterm record of subpolar north atlantic circulation through crossdisciplinary crossborder collaboration between the french institute for ocean science host university of iceland secondment and copenhagen university the proposed study will compile new proxy analyses with the expanding coverage of instrumental observations to provide a confident reconstruction of the regions hydrography and dynamics over the past two millennia ultimately the project findings will be effectively delivered to the decision makers the young generation and the general public through participation in policy works at jpi oceans placement university teaching and outreach activities the multimodal delivery of project findings aims to raise awareness of the severity of a longterm amoc decline and to facilitate cooperation for timely mitigation of potential socioeconomic consequences
practice and science broiler production innovation network

broilernet will create twelve national level innovation networks and three eu level networks of broiler farmers advisors supply chain integrator companies farmers organisations researchers and veterinarians to address the upcoming challenges faced by broiler farmers the project will be designed around three main fields of concern 1 environmental sustainability 2 animal welfare and 3 animal health management through a multiactor approach the most urgent needs of broiler farmers will be identified and the network will collect and evaluate good practices that are able to meet these needs broilernet will also engage with existing and new broilerfocused eipagri operational groups ogs and enhance their impact the selected best practices will be spread through a variety of communication and dissemination activities to reach the vast majority of broiler farmers in the countries of the participating consortium partners but also to all broiler farmers across europe numerous multilanguage flyers videos and national roadshows are just some of the dissemination methods that will be foreseen among the activities dedicated to communication and dissemination