Dragon09/odtu_chatbot huggingface dataset:
trichomemediated crop resilience at cotyledon stage exploring the biosynthesis regulation and function of glandular trichomes in the production of defensive specialized metabolites

plants evolved diverse strategies including the production of specialized metabolites to adapt to changing environments these specialized metabolites are often linked to glandular trichomes gts density to study gts biology cultivated tomato and their wild relatives are considered ideal models varying in gt types i iv vi vii and associated metabolites while type iv gts rich in acyl sugars as persist throughout the life cycle of wild tomatoes in cultivated varieties they explicitly appear in early stages especially on hypocotyl and cotyledons as provides resistance to various pathogens including whiteflies a significant threat to global tomato production although the role of type iv gts and as in adult plant resilience is understood their regulation at the juvenile stage remains unknown this study aims to address these knowledge gaps employing an integrative omics approach in the early developmental stages of cultivated tomato and their wild relatives while factor like plant hormone jasmonic acid ja is known to influence the development of type vi gts and terpenoid metabolism the jamediated regulation of type iv gts and as metabolism remains unidentified the present proposal aims to tackle these crucial knowledge gaps by utilizing combinatorial forward and reverse genetics approaches furthermore this project aims to explore the ecological functions of type iv gts and as in shaping the plant microbiome at the cotyledon stage a yet unknown aspect of plant fate through an interdisciplinary approach including genetics transcriptomics metabolomics and microbiome analysis the research aims to offer comprehensive insights into plant defense mechanisms and adaptation strategies in early developmental stages the outcomes of this research will revolutionize our understanding of plant resilience at juvenile stages thereby contributing to the progress of sustainable agriculture and offering new opportunities for crop improvement
assumptionlean causal modelling and estimation a paradigm shift from traditional statistical modelling

i propose a cuttingedge and transformative paradigm for statistical modelling that is crucial to enhance the quality of data analyses leveraging my expertise in causal inference and semiparametric statistics i will establish the fundamental principles of a comprehensive estimation theory which maps model parameters onto generic interpretable modelfree estimands eg association or effect measures with favourable efficiency bound and harnesses the power of debiased statisticalmachine learning techniques to estimate these my core objective is to develop a flexible and accessible data modelling framework called assumptionlean modelling this framework will deliver minimal bias and maximal interpretability even in the presence of model misspecification along with honest confidence bounds that account for model uncertaintydebiased learning is at the core of this research while gaining popularity a rigorous scientific optimality theory is lacking i shall draw on my expertise in biasreduced double robust estimation to develop optimal debiased learning estimators these utilize learners that optimize strategically chosen loss functions to achieve low variance and high stability along with confidence intervals that are valid under weak conditions on the learnersi will connect to timely exciting developments in statistics such as debiased learning of functionvalued parameters and the construction of confidence bounds for such parameters i will offer novel avenues into these problems by incorporating the assumptionlean modelling principles and connecting to realworld needsi will develop assumptionlean modelling strategies to tackle significant challenges in causal modelling including target trial emulation causal mediation analysis and statistical modelling of dependent outcomes i will deliver methods with potential impact on all empirical sciences as well as on the foundations of the discipline of statistical modelling
reforming secondary plastics to become the primary raw material choice for addedvalue products

polymers are one of the most used materials in different applications especially in consumer goods like electronics and the consumption is only expected to rise globally in europe 258 million tonnes of plastic waste is generated annually and less than 30 is collected for recycling and significant shares are exported from eu to be treated elsewhere landfilling 31 and incineration 39 of plastics is high together 70 and by these treatment options the valuable materials are lost from circulation it is estimated that 95 of the value of plastic packaging material between 70105 billion eur is lost annually to the economy after a very short firstuse cycle the industry is lacking standards and main barriers for efficient uptake of recyclates are due to safety concerns low quality and recycling rates primus activities will increase the resilience of eus plastic value chains by securing supply of waste plastics as feedstock and increasing its availability through connecting value chain actors developing methods to control quality sampling and analysis and improving upgrading knowhow and characterize suitability towards addedvalue products primus will prove legislative compliant privacypreserving costefficient and feasible technological pathways for tapping into nonrecycled or underutilized plastic waste streams validated business cases will lower the risks of future investments into european manufacturing capacity primus will address one of the core challenges identified in the eu circular economy action plan the presence of hazardous substances brominated flame retardants and how to effectively and safely debrominate the waste streams for new product use primus will contribute to circulating underutilised or nonrecycled streams and create further impact by supporting additional production of 02 mtonnes of rhips rpcabs repdm and rtpe which is approximately 6 of the expected growth of european recyclate market 20182024
artificial lanthanide enzymes for selective photocatalysis enlightening metalloenzyme design and evolution

enzymes are efficient and selective biocatalysts they are in high demand in chemical and pharmaceutical industry as they facilitate more sustainable production processes however it remains challenging to develop novel enzymes that catalyze reactions beyond natures synthetic repertoire to tackle this problem i propose a fundamentally new approach that merges metaldependent chemical photocatalysis with enzyme engineering photoexcitation is a powerful catalytic tool it enables alternative modes of substrate activation by generating radical intermediates controlling these reactive species to confer regio and stereoselectivity however is a major challenge in synthetic chemistry the key idea of this proposal is thus to perform photocatalytic reactions inside the chiral environment of artificial metalloproteins which can be optimized efficiently by directed evolution my group recently established the formation of lanthanideprotein complexes from highly stable computationally designed protein scaffolds based on this work we now aim to engineer a photoenzymatic platform for synthetically valuable chemistry the main goal is to implement and optimize lanthanide photocatalysis in these proteins to facilitate stereoselective ch activation and cc bond forming reactions moreover a fundamental mechanistic understanding how such new photocatalytic function emerges in proteins will be crucial for enzyme engineering to that end i propose a strategy that mimics natural evolution in a twostep process starting from libraries of naive small proteins a highthroughput screen will first identify lanthanide binders which are then exposed to a selection system that couples the survival of a bacterial host to an enzymatic detoxification reaction photolanzyme will yield a new class of sustainable and stereoselective photobiocatalysts the approach is transferable to other photoredoxactive metals emphasizing its broad potential for synthetic applications
robust privacypreserving biometric technologies for passengers identification and verification at eu external borders maximising the accuracy reliability and throughput of the recognition

popeye unique value proposition focuses on a strengthening the security at the external eu borders through fusing robust biometric technologies for verification and identification b maximising the travellers experience when crossing the external eu borders through unobtrusive onthemove biometric technologies c improving the productivity of border authorities and law enforcement agencies in performing identification and verification of people on the move and without stopping them at up to 200m distance when multiple travellers cross borders on foot or inside the same vehicle in different nature eg openair conditions night time time constraints space constraints etc popeye will introduce novel and robust biometric technologies in the five areas identified by the aforementioned frontex report combined with gait recognition in order to maximise the impact and the return on investment in short term popeye through the proposed technologies will support both eu and third country nationals tcn citizens will be compliant with existing and upcoming regulations such as gdpr and ai act will comply with the ethics guidelines on trustworthy ai 2019 will empower the eu values and fundamental rights including on data protection and avoid bias and discrimination
building the next generation of marine ecofriendly wind farm

the demands on marine space in the eu and worldwide waters have never been greater driven by the need to provide energy security develop essential renewable energy infrastructure create social and economic value and ensure the restoration and future resilience of marine biodiversity and ecosystem services whilst offshore wind farms owfs play a key role in combatting climate change they are not only vulnerable to climate changeinduced hazards but also impact marine biodiversity focusing solely on engineering aspects to optimise risks and reliabilities in the design of owfs without addressing the impact on marine biodiversity is sufficient for meeting the requirements of resilient and sustainable development in future owfs therefore an urgent shift is necessary from the conventional engineeringoriented design approach and mindset to a more comprehensive approach that integrates both engineering aspects and environmental considerations better assembles a diverse multidisciplinary team to train a new generation of doctoral candidates dcs capable of addressing ambitious scientific objectives the training environment is highly integrated crossdisciplinary and intersectoral enriched through secondments with nonacademic partners this collaborative approach advocates for a paradigm shift in owf design promoting a comprehensive strategy that integrates engineering with deep considerations for environmental impacts better emphasises critical learning fostering solutions for climateresilient owf construction and sustainable marine development by providing a collaborative crossdisciplinary training environment better equips the 15 dcs with the skills knowledge and perspectives to navigate the intersection of engineering environmental sustainability and marine biodiversity in doing so better addresses immediate challenges and lays a foundation for a sustainable and resilient future for offshore wind energy and marine ecosystems
modelling food plant trade in the roman provinces of gaul and britannia

food is at once a universal necessity and subject to the particularities of environmental and sociocultural setting examining trends in food consumption provides a means with which to detect shifts in past economies and can greatly augment current understandings of the ways ancient populations interreacted with each other as well as their environments this project will explore the diverse ways that roman imperial occupation impacted provincial lifeways as reflected in foodways or more specifically food plants as food plants were a traded commodity tracking their trade and transport allows important new light to be shed on economic connectivity trade networks as well as culturescapes and the intricate social dynamics that influence consumption patternsthe focus will be on the roman provinces of britannia and gaul regions which are historically and geographically distinct but also interconnected in terms of their proximity and necessary transport links a large body of archaeobotanical data will be collated and entered into a relational database data analyses will look to methods from computational archaeology employing underutilised techniques of advanced network analyses in order to model spatial and social distributions in food plants in acquiring these new skills the candidate will be able to combine such methods with existing expertise in largescale regional archaeobotanical studiesresults will complement current knowledge on food plant trade by filling the essential gap that is the geographical centre of the european provinces gaul as well as shedding new light on trade in the frontiers implications will be farreaching offering novel insight into socioeconomic networks as well as humanlandscape relationships and complex nature of cultural dynamics within imperial spheres such topics are not only of great relevance to the ancient world but also to modern studies of food and the impacts of the global economy
shaping the future of epr with cryoprobes and superconducting microresonators

electron paramagnetic resonance epr is a highly powerful tool employed across different disciplines including structural biology material science quantum information processing and many others epr provides essential information about a local unpaired electron spin environment electronic properties and dynamics of various paramagnetic centers however a relatively low sensitivity of a conventional epr often limits its applicability to study smallvolume systems eg single biological cells recently major advances in the epr sensitivity enhancement have been achieved in the field of quantum information processing using superconducting microresonators and lownoise cryogenic microwave preamplifiers the full potential of this highly sensitive epr approach to investigate typical spin systems in other areas still remains to be shown which is critical for its wider application in different scientific disciplines the main goal of this marie skodowskacurie project is adaptation of these developments to study conventional spin systems and their application to solve currently eprinaccessible intriguing problems in biochemistry the spin systems to be studied include a miniature amount of spin labels a single rnabinding protein droplet and spins in a single bacterium the researcher dr mantas imnas will be employed in his home country lithuania at vilnius university vu under the supervision by prof jras banys he will bring to vu a valuable experience on epr of various spin systems cryoprobeheads and microresonators gained during his postdoctoral fellowship at university college london during the project the researcher will grow as a specialist of highly sensitive epr techniques and their applications acquire new knowledge of spins in biochemical systems and reach scientific maturity
increasing lutetium production while leveraging metabolic imaging to enhance theranostics effectiveness

selective targeting of therapy with antibodyradioisotope combinations have led to major advances in treating cancers that are resistant to common therapies such as castrateresistant prostate cancer adding lutetium177psma lu177psma to standard care significantly prolongs survival however the increased use of lu177based therapies has resulted in an increased demand for this isotope leading to shortage risksin addition despite the success of lu177treatment 30 of patients do not benefit from treatment but do suffer from sideeffectsilluminate will improve the availability and use of theranostics across its value chain by taking a hybrid approach 1 imaging capabilities will be improved by implementing novel broadly applicable scalable and highly effective metabolic magnetic resonance imaging memri which are expected to give better and faster insight into treatment responses allowing better patient stratificationand treatment personalisation 2 the availability of lu177 will be fortified by improving its manufacturing process and by developing sustainable production methods to help meet the general need for radioisotope based therapies and increase eu autonomy the illuminate consortium industries philips nrg bracco tesladc wavetronica lygature sdn eurobioimaging and the univerisities of torino lund amsterdam umc klinik essen coordinated by umc utrecht uses the example of lu177psma as a showcase clinical trial in 150 patients for broadly applicable innovative technologies in the field of theranostics and radioisotope manufacturing for oncology
phoenix precision human organsonchip for enhanced neuromuscular and cardiac studies

phoenix aims to revolutionise biomedical research by developing the next generation humanbased organsonchips ooc ooc is a promising technology potentially able to outperform conventional preclinical models in providing pathophysiologically relevant setting for investigating human diseases thus tackling the limited translational value of animal testing ooc wide adoption is currently hampered by poor maturation of cellular models and shortage of nondestructive readout methods phoenix will take current ooc platforms to the next level overcoming such limitations by integration of core technologies already validated by the consortium namely electric recording 3dmea force sensing 3dforce and mechanical stimulation 3dmechtwo platforms will be developed i heart to model functional cardiac tissues and ii nmc to model neuromuscular circuits phoenix ecosystem will be completed by satellite products and qualified against specific contexts of use in clinically and industrially relevant environments phoenix potential will be showcased with two genetic pathologies as demonstrators lmnacardiomyopathies and freidreichs ataxia conditions in which electrical instability and mechanical impairment play important roles for each platform two versions will be released base and pro addressing the need of identified customer segments research labs and pharmabiotechin line with the 3rs phoenix platforms represent the ideal clinically relevant tools to test drugs and gene therapies leading to fastersafer development processes reducing the need for animal testing robust dissemination exploitation and communication activities will address both key stakeholders ooc players endusers endbeneficiaries and regulatory bodies and society at large fostering acceptance adoption economic viability and regulatory compliancephoenix will last 4 years with a consortium comprising 9 partners academic smes and les from 4 eu countries
dynamic and reconfigurable data centre networks with modular optical subsystems

dynamos develops fast 1 ns and widely tunable 110 nm lasers energyefficient fjbit broadband 100 ghz electrooptic modulators and highspeed 1 ns broadcastandselect packet switches as photonic integrated circuits pics dynamos meets the expected outcome objectives and call scope by proposing the development of low energy few pjbit pics which are integrated into modular and scalable subsystems and subsequently utilized to demonstrate novel data centre networks with highly deterministic submicrosecond latency to enable maximum congestion reduction full bisection bandwidth lower congestion and guaranteed quality of service while reducing cost per gbps the proposed network offers optical circuit switched reconfiguration and guaranteed contentionless fullbisection bandwidth allowing any computational node to communicate to any other node at fullcapacity dynamos builds on recent developments in iiiv optoelectronics thick silicononinsulator waveguide technology and silicon organic hybrid soh modulators it codevelops the entire ecosystem of transceivers switches and networks to boost overall performance and to reducing the total cost of data exchange instead of focusing on the improvement of individual optical links or interfaces the objectives of dynamos perfectly match the major photonics research innovations challenges defined in the photonics21 multiannual strategic roadmap 20212027
the path towards addressing adverse impacts of light and noise pollution on terrestrial biodiversity and ecosystems

the rate of global biodiversity decline is unprecedented and accelerating urban sprawl population growth and industrialization bring previously unrecognised drivers of biodiversity loss including light and noise pollution the eu has adopted policies including the eu green deal and the eu biodiversity strategy for 2030 to enable transformative change through better protection of biodiversity and nature restoration activities however current projections suggest that the eus 2030 biodiversity target will not be met an alternative plan is required planb takes an integrated multidisciplinary and multiactor approach to deliver better understanding and support reduction of light and noise pollution impacts on terrestrial biodiversity and ecosystem services key outputs of planb include a framework and supporting handbook for assessing light and noise pollution impacts to inform environmental decisionmaking an open access database on light and noise impacts on terrestrial biodiversity spatiotemporal models for evaluating noise and light impacts on terrestrial biodiversity and ecosystem services including at the european scale innovative solutions to prevent and mitigate light and noise pollution impacts recommendations for enhancing legal and policy frameworks to reduce light and noise pollution impacts on terrestrial biodiversity and sustainable communities of practice cops centred around key stakeholder groups on the impacts of light and noise on terrestrial biodiversity working with european and international partners including from brazil cops key networks eg biodiversa and the horizon europe sister project on aquatic biodiversity and ecosystems planb will maximise its global reach and research impact through its work programme planb will create the enabling conditions to support and enhance activities planned in the eu biodiversity strategy and provide a new path towards meeting the eu and international biodiversity targets