Dragon09/odtu_chatbot huggingface dataset:
causal roles of intrinsic coupling modes an integrated multiscale framework for cognitive network dynamics

functional coupling is a hallmark of brain networks and there is a wealth of studies that have observed a relation between functional connectivity and cognition or sensorimotor processing however the vast majority of studies on this topic are correlative in nature and causal evidence for the role of functional coupling is almost completely lacking this project aims to fill this gap most of the coupling is intrinsically generated and occurs at multiple spatial and temporal scales we will focus on two different types of such intrinsic coupling modes icms phase icms arising from phase coupling of oscillatory signals and envelope icms resulting from coupled fluctuations of signal envelopes the central hypothesis of this project is that both types of icms have causal relevance for cognitive processing and behavior we will systematically manipulate analyze and model the different types of icms to establish an integrated view on their functions and interrelations which currently is still lacking specifically we aim to obtain the missing causal evidence on functional roles of icms to unravel how phase and envelope icms differ in their relation to cognition and behavior to reveal differences in the underlying mechanisms and to unravel potential interactions between both types of icms we will apply a translational approach which combines meg recordings and tacs in humans with invasive electrophysiology and optogenetics in ferrets we will use targeted multisite interventions to dissect icms independently manipulate phase and envelope coupling and test the impact on cognitive processing and behavior the experiments will be complemented by informationtheoretic analyses and computational modeling of icms this cuttingedge research program will yield an integrated multiscale framework for icms that is likely to have farreaching implications for a better understanding of the mechanisms underlying cognition and the complexity of the human mind
informal innovations insights from artisan clusters and makerspaces in india

innovation is considered to be the engine of economic development for any nation this is why studies on innovation have gained immense scholarly attention from different disciplines giving various insights however one major limitation of the studies on innovation has been their emphasis on the formal structures of the economy like rd institutes firms and industries there is very scant literature that focuses on the innovations which emerge in informal environments in academic literature there have been no agreed frameworks that are targeted towards the innovations generated within the informal contexts the limited amount of attention it received revolves around the concepts such as frugal innovations grassroots innovations or jugaad moreover policy thinking has been to suppress the informality and transfer it into the rigid formal sector in view of the limited focus on innovations within the informal settings in india this project proposes to study innovations developed in informal settings such study will offer rich insights into the innovative activities local resources knowledge and collaborations that contribute to innovations the project proposes to take two sites showcasing the rich prevalence of informal innovations the first site will be of a traditional artisan cluster whereas the second site will focus on a more modern case of informal innovations represented by the makerspaces this study will be useful to understand and compare the innovation characteristics in two different settings both representing some form of informality my project infoinn aims to1 study the networks collaborations and modes of learning among the different actors which facilitate innovations within the informal structure and 2 theoretically advance the literature on innovations by studying the informal contexts that will pave the way to open new perspectives on how to methodologically study and measure innovations in such contexts
wearable integrated soft haptic display for prosthetics

in this erc proof of concept we want to develop a wearable fluidic force feedback device for upper and lower limb prostheses composed by soft silicone chambers along with their actuation and control units to exert pressures in multiple specific stump sites this solution named wearable integrated soft haptic device wish strives to achieve both good modality matching mm and somatotopic matching sm while keeping noninvasive and practicable the principle preliminarily demonstrated on a single subject and one prosthesis type to display one type of forcetactile information has the potential to generalize in several directions our goal is to transform wish into a technology platform supporting different devices for different types of prosthesis available in the market for both upper and lower limbs we will depend on user involvement team with hospitals and rehabilitation units and work with companies producing prostheses see endorsement letters to acquire domain specific knowledge and to test our devices in real use cases through this project our technology readiness level will increase from 3 to 45 and enable us to apply for an eic transition for subsequent development and validation in a larger cohort to the best of our knowledge no other haptic display technology for prosthesis users has ever reached such maturity and readiness level which makes this opportunity unique
scalingup quantum computers with quantum memory links

fully achieving the many promises of quantum computing will require dramatically scaling up the number of quantum bits qubits that quantum computers manipulate the only way consists of interconnecting several midsized quantum processing units qpus in clusters to effectively multiply qubit countswelinq is building the essential interconnection technology to support modular quantum architectures by combining the worlds best quantum memory and novel networking protocols to construct quantum links our unrivalled ondemand storageandretrieval of quantum light enables us to efficiently entangle separated qpus enabling larger and more powerful quantum computerssqout will ensure the adaptability and scalability of welinqs fullstack solution to drive the global market adoption of our turnkey quantum links our internationally renowned team has unsurpassed technical expertise alongside quantum business commercialization experience with eic support welinq will make the interconnection of qpus a reality and secure europes quantum industry leadership
quantum gravity searches with neutrino telescopes

the standard model of particle physics and general relativity are expected to merge into a new theory of quantum gravity qg at energies approaching the planck scale however none of the proposed qg approaches has been validated to date in this context several signatures of qg effects in accessible energy regimes known as windows on quantum gravity have been postulated in particular quantum decoherence qd or qginduced violation of lorentz invariance liv could cause modifications in neutrino oscillation patterns accessible to observation with neutrino telescopes with qgrant i propose a global and novel search for qg effects with the icecube antares and km3net neutrino telescopes the expected results will allow to probe qd and liv parameters regions not accessible to date moreover the phenomenon of qd will provide new possibilities to investigate the neutrino nature as a dirac or majorana particle as well as to trace possible violations of cpt symmetry in neutrino oscillations such a phenomenon represents a totally new scenario where to test the real nature of neutrinos within qgrant i will analyse the huge amount of data collected by icecube antares and km3net europes most ambitious project of a high energy neutrino telescope whose effective mass angular resolution and wide energy coverage will make it an ideal instrument to further this research area the proposed analysis will provide unprecedented sensitivity to qg effects and it will open uncharted territory for new discoveries a planned cooperation with experts on qg will reinforce the theoretical impact of qgrant in terms of qg models the erlangen centre for astroparticle physics with its globally unique situation of hosting icecube and antareskm3net groups together with the quantum gravity institute represents the perfect host institution for my proposed research and my development as an independent physicist
understanding of the membrane connection linking the nucleus to the endoplasmic reticulum

compartmentalization into membranebound organelles is a key feature of all eukaryotic cells and communication between organelles needs to be tightly controlled a key organelle for the interorganelle communication is the endoplasmic reticulum er which is the major site of lipid and membrane protein synthesis the er exchanges molecules by forming stable contact sites with multiple organelles such as mitochondria via specific tethering proteins and transporters in contrast to these contact sites the er is linked to the nucleus via direct fusion to the outer nuclear membrane of the nuclear envelope ne these erne junctions are essential for supplying the lipids and proteins that are synthesized in the er to the ne hence nuclear function and morphology depend on the proper communication via erne junctions however the biogenesis architecture and maintenance of erne junctions have remained elusivewe have recently found that erne junctions exhibit a narrow and constricted ultrastructure during the cell cycle in mammalian cells these observations led us to postulate that erne junctions are formed and maintained by specific membraneshaping proteins that are crucial for nuclear function here we propose to identify the molecular mechanism that governs the structure and function of erne junctions we will provide a quantitative and dynamic highresolution view of these enigmatic structures by combining timeresolved electron microscopy and quantitative live imaging with molecular perturbations using these datasets we aim to develop a mechanistic model of how erne junctions form and contribute to nuclear functionthe ne proteins supplied via erne junctions have critical roles in gene expression nuclear organization and nuclear pore biogenesis as well as in differentiation development and disease therefore our research will provide a new conceptual framework that will open lines of investigation in many fields beyond erne biology
investigation into reasons for drinking among adolescents and young adults a gender perspective

in europe 535 of adolescents consume alcohol in excess but what has attracted attention is the increase in consumption among girls these used to drink less than boys but now their consumption is equal and on some contexts larger than boys how this happens in europe where it can be considered a trendsetter should be a global concern thus understanding the reasons for this behavior change is essential to develop prevention program strategies that are effective in young people existing programs are not successful they do not focus on specific gender situations and also on the mechanisms involved in this process in addition studies to date do not have a quantitative assessment as there are no instruments to unravel the reasons for alcohol consumption from the perspective of gender difference current studies have only a qualitative assessment it is impossible to compare groups of people and populations making a global view of this field unfeasiblethus the proposal will unravel the determinants of alcohol consumption in adolescents and young adults from a gender perspective this will be a paradigm shift in the knowledge of alcohol consumptionohgender is highly original and innovative as it provides a new instrument for quantitative assessment and will deliver a new model of consumption of alcohol determinants by an advanced technique of statistical analysis structural equation model advancing the field of gender disparity a tool to identify the different needs between girls and boys disclosing the determinants of alcohol consumption from a gender perspective will be an advance in the state of the art filling this unexplored knowledge gap the proposal will advance in the field of alcohol consumption prevention and has the potential to be an ongoing study after pf
support to eic accelerator by the enterprise europe network

the objective of een2eic is to empower een network offices support potential eic applicants specifically women entrepreneurs and widening countries and seal of excellence soe holders the project aims to develop a strong cooperation mechanism between the european innovation council and een in order to support innovation and scale up companies een2eic will involve the most relevant actors in the eic and een landscape the enterprise europe network een the eic ncps network access2eic een2eic aims to focus on specific outreach and support activities increasing the number of quality proposals to eic calls with a specific focus in widening countries as well as women innovators assisting seal of excellence holders access alternative sources of funding and guarantee a strong and profitable exchange of best practice within een een2eic overall objective is to make eu innovation support more efficient by improving the capacity of smes to apply to the eic and by helping soe holders finance their projects and to avoid overlapping with ncps activities
cybersecurity for aiaugmented systems

with aienhanced components being deployed everywhere including the very toolchains used for secure software development the traditional security focus on software and hardware assets can no longer guarantee secure services processes and products and digital infrastructures in the eu strategic plan 20212024 sec4ai4sec wants to develop securitybydesign testing and assurance techniques for aiaugmented systems their software and ai assets aiaugment systems provide an opportunity to democratize security expertise and give access to intelligent automated secure coding and testing by enabling novel capabilities lowering development costs and increasing software quality ai4sec they are also a risk aiaugmented systems are vulnerable to new security technical threats specific to aibased software in particular where matters of fairness or explainability are important sec4ai sec4ai4sec addresses these challenges to the fullest extent ai for better security security for better aithe sec4ai4sec project will address these two facets of ai to achieve a deep scientific economic and technological impact while contributing to addressing key societal issues it will validate its approach on three key scenarios of the eu digital compass towards digital sovereignty 5g core virtualization autonomy for safety systems in aviation and security and quality for 3rd party software assessment and certificationsec4ai4sec assembled a team with 5 leading universities amsterdam cagliari hamburg lugano trento 2 innovative smes frontendart pluribus one 3 large enterprises airbus sap thales and 1 center for digital innovation cefriel the project will generate a set of innovative techniques and opensource tools new methodologies for secure design and certification of aiaugmented systems as well as reference benchmarks that can be used to standardize the assessment of research results in the secure software research community
strengthening the critical raw material independence of the eu through thermochronology

the rapidly increasing green technology transition efforts of the european union to combat climate change resulted in an unprecedented demand for critical raw materials like rare earth elements cobalt nickel and even base metals these materials are core components of wind turbines and electric cars however to fulfil these needs the eu heavily relies on countries with a high risk of supply chain disruption due to political instability therefore the exploration efforts to find new deposits within the eu borders are crucial to securing economic independence and realising a co2free society the swedish part of the fennoscandian shield has serious potential to discover new deposits for instance it hosts the largest rare earth element reserve in the eu the areal extension of the fennoscandian shield is over 1 million km2 and composed of complex magmatic metamorphic and metasedimentary rocks dating back to archean over time due to multiple orogenic events critical raw material deposits formed and remobilized in diverse ways understanding the formation mechanisms is crucial to locating them my project critter strengthening the critical raw material independence of the eu through thermochronology will be the first study to reconstruct the thermal history of the fennoscandian shield from a critical raw material perspective it will be achieved by the interdisciplinary combination of novel hightemperature mica insitu rbsr dating at the dept of earth sciences gothenburg and by lowtemperature zircon rutile insitu upbhe double dating at the geoscience center göttingen these are worldclass laboratories in their respective field the research will target five key critical raw material deposits in the bergslagen ore province of southwestern sweden the findings will fill a decisive knowledge gap in identifying the nature and timeline of reheating and subsequent ore remobilization and redeposition events from proterozoic to present times
reducing the footprint of consumer products through public dialogue and innovative biobased materials

inguma aims to foster the development of biobased materials and their acceptance by the public by relying on three main values sustainability inclusion and aesthetics the values of the new european bauhausthe value of sustainability will be tackled by developing different types of biobased materials from raw materials derived from agriculture residues and secondary raw materials from wood processing various types of materials will be developed functionalized fibers insulation material based on mycelium resinfree insulation material based on wood fibers biobased adhesive for plywood lowformaldehyde plywood board wooden sandwich panels and growth media for plants in addition these materials will be integrated into insulation panels and vegetated roofsthe sustainability and circularity of these materials and solutions will be ensured by applying environmental criteria and digital tools that will allow users to make decisions on the most sustainable solutions available additionally the materials will be tested according to european and international standards as a first step in the commercialization outside of europe canadathe value of inclusion will imply the design of cocreation laboratories that encourage collaboration among stakeholders fostering transparent communication and generating innovative ideas these labs will provide a platform for engagement and a structured process for stakeholders to contribute their insights and actively participate in the development of biobased construction materials this way the acceptance of the developed materials products and solutions by endusers and consumers will be maximizedthe value of aesthetics will be accomplished by co designing and constructing a community house prototype in the rooftop of an experimental building derio spain and as part of test houses savonlinna finland that will use extensively the materials and products developed
analysis of biofilm solid interactions underpinning wastewater treatment

wastewater treatment wwt processes that use biofilms as their biocatalyst have been in use for over 100 years over the past few decades a greater understanding has emerged on how biofilms can be exploited for enhanced nutrient removal and this knowledge has been translated into new technologies representing about onethird of all wwt processes in a multibillioneuro global wastewater technology marketdespite the success of these technologies there is significant need for enhanced efficiencies in these processes and the development of new technologies that are more energy efficient and are capable of better resource recovery from wastewater are needed to achieve this there is need for new mechanistic insight in particular the interaction between biofilms and particulate organic matter in the influent wastewater the knowledgegap spans three key areas i nonoxidative interactions ii hydrolysis and iii bioflocculation this research project will develop an enhanced multispecies biofilm model that better incorporates new understating of these areas we will go significantly beyond current state of the art by first building an experimental platform that exploits recent developments in advanced imaging nanosensors particletracking to probe the fundamentals of these mechanisms to achieve this the platform will be uniquely based on fluorescently tagged monospecies biofilms rather than on conventional multispecies biofilm in a first phase of the project this work will then inform the development of new mathematical model relationships which will be implemented in an extended multispecies model and validated against data from a pilot plant operating with conditions representative of a real wwt plant the transformative approach in this project will lead to a more fundamental insight into the mechanisms underpinning particlebiofilm interactions and pave the way to new application of biofilms for advanced wastewater treatment
interactions with future reachthrough volumetric displays

displays in the shape of televisions computer screens or phones are ever present in our education work and entertainment however they do not take full advantage of our inner spatial abilities that we have to interact with the real world true 3d displays can provide the same visual clues as the real world without forcing the users to wear devices however with state of the art soa displays the users cannot reach inside the display volume to directly interact with the virtual objects as they would do in real life we envision a volumetric display capable of projecting true 3d virtual objects in midair that can be reached by the users to enable direct interaction ie a reachthrough volumetric display rvd this vision has been presented in multiple movies and books but there is no realizationthree novel technologies will be developed and combined to create an rvd 1 fast timemultiplexed acoustic fields will create virtual force fields that give shape to microfabricated lightscaterring particles 2 tomographic illumination will shine on the particles as a more scalable alternative to phasebased holographic 3 volumetric tracking of the particle distribution will control the previous technologies in a closedloop manner applications will serve as benchmarks to test novel interaction techniques and develop a framework that fills in the knowledge gap for interactions with as yet nonexistent rvds the objectives of the project are o1 find a set of technologies that enables the realization of rvds o2 create interaction techniques for rvds and categorize them using a framework that will be applicable to future displays our current frameworks for 3dinteractions may not be applicable to rvds o3 enhance an rvd with tactile sensations spatial audio and study its effects on humans the pi is uniquely qualified with experience in designing midair interactions and using levitated particles for displays