Dragon09/odtu_chatbot huggingface dataset:
multimodal 4dtherapy of pediatric high grade glioma

paediatric high grade glioma phgg is the most common malignant childhood brain tumour with standardofcare inevitably resulting in therapyresistant relapse or disease progression the need for new combinatorial treatments is universally acknowledged however modern combination therapies are sparse include at most two modalities and have so far not been able to significantly improve the dismal prognosis of the diseasein this proposal i conceptualize a highly targeted multimodal treatment strategy for phgg 4dtherapy based on complementary precision medicine approaches the system leverages multiple intermodal synergies overcomes resistance to individual therapies and disperses offtargeting to different cell populations thereby creating a large therapeutic windowinitially we will conduct a comprehensive screen to evaluate a novel regimen of combined upfront targeted drug and radiotherapy rt followed by functional validation in vitro and in vivo indepth molecular profiling will allow us to unravel mechanisms of radiosensitizationfurther we aim to establish an innovative gene therapy approach with unprecedented highly specific tropism for tumour cells by combining elaborately selected adenoassociated viruses and nanocapsules with newly identified casnucleasesultimately we will systematically combine drugrts gene therapies and existing tumourspecific cart cells within a rationally designed multimodal treatment regimen and evaluate its efficacy in a series of preclinical studies a broad representation of patientderived xenografts complemented by immunocompetent allograft models will provide leadingedge predictive power and a unique dataset to investigate multimodal interactionsi expect this project to provide pioneering insights into intermodal treatment synergies to produce stratified treatment protocols for phgg directly informing clinical trials and to become a pathbreaking feasibility study for multimodal cancer therapy
realtime multiscale imaging of pathological calcification zooming in on aortic valve calcification

calcifying aortic valve disease cavd is a cellulardriven disease that actively alters the structure and composition of the valve extracellular matrix leading to severe disfunction of the heart because the molecular mechanisms underlying cavd are still unknown there are currently no drugbased therapies and valve replacement is the only available treatmentspecifically it is still unknown 1 how the disease modifies the extracellular matrix ecm to become susceptible for mineralization 2 how cell differentiation and matrix modification lead to calcification and 3 how the mineral develops within the matrix we lack these answers mainly due to our inability to characterize matrix development with the required chemical and structural details during the cavd process i aim to push our capability for in situ imaging of ongoing biological matrix formation processes from the micron to the nanometer scale by creating a designer tissue imaging platform for cavd this will be achieved by creating a human cavdonachip that allows the application of mechanical and biochemical cues to accurately emulate the early stages of cavddesigning the chip to accommodate a 3d correlative multiscale imaging and spectroscopy workflow to study matrix modification and mineralization in the native state from the micrometer to the nanometer scale developing a method to 1 collect cryosections from the ecm created at precisely selected points in space and time to 2 transfer these to a transmission electron microscope and 3 revive inside the microscope the biological processes that are ongoing in the at the moment of cryoarrest this will allow for the firstever dynamic nanoscale imaging of ongoing ecm processesthese new capabilities will allow breakthroughs in understanding the role of matrix interactions in aortic calcification opening the way for future development of drugbased treatments for cavd
network for european exascale systems

the net4exa project aims to create an advanced interconnect for hpc and ai systems including large language models that will scale to hundreds of thousands of computing nodes the interconnect forms the backbone of such systems and their overall performance is intimately tied to the scalability of the network and its tight coupling with the highend compute elementsbuilding on the successful bxi european hpc interconnect whose earlier versions bxiv1 and bxiv2 have been deployed in european supercomputers ranking among the top15 and based on the research for its evolution carried out in the redsea and other previous european ria projects net4exa will pursue the development of the next generation of european interconnects bxiv3 this includes both the switch and network interface encompassing both hardware and its associated software the project will showcase a fully functional pilot at trl 8 poised for adoption and integration into exascale and postexascale european supercomputersnet4exa will also prepare the subsequent version bxiv4 planned for implementation after this innovation action the project will contribute by offering analysis and preliminary design for upcoming interconnect features thus paving the way for continued progress in the fieldleveraging two decades of bull experience in building hpc solutions with now more than 40 top500 entries in 2024 the project outcomes will fit the technological requirements for stateoftheart hpc solutions to be implemented in european and international supercomputers and datacentres from 2025 onwardbxi bullsequana exascale interconnect
biomarkers established to stratify sepsis longterm adverse effects to improve patients health and quality of life

sepsis is a lifethreatening organ dysfunction resulting from dysregulated immune responses to infection affecting almost 50 million people yearly sepsis is a major global health challenge and a leading cause of death worldwide moreover people surviving sepsis often suffer postsepsis immunosuppression a longlasting state of immune dysfunction predisposing them to infections autoimmune and noncommunicable diseases ncds and longterm reduced fitness the molecular mechanisms driving postsepsis immunosuppression remain largely elusive furthermore predicting which patients will survive or develop immunosuppression is currently impossiblebeatsep will tackle this challenge by combining the expertise of physicians clinician scientists and immunologists in top european institutions we will for the first time longitudinally assess unique immunological and clinical parameters and combine them to i gain insight into the longterm immunological consequences of septic shock ii identify novel markers to identify patients at risk and iii unravel molecular mechanisms driving postsepsis immunosuppression we will also develop strategies to improve the stratification of acute sepsis survivors to identify patients with a higher risk of sepsisassociated ncds and comorbidities beatsep will have significant societal scientific and economic impacts as efficient prevention of sepsisinduced comorbidities could save significant amounts within healthcare budgets and potentially improve the quality of life for millions worldwide who suffer from the longterm effects of sepsis
spacetime and vectorial metaoptics for highpower structured lasermatter interactions

plasma is an extreme form of matter at the heart of important applications like fusion and particle acceleration the creation and control of plasma require highpower lasers now increasingly within reach often operating at terawatt or petawatt levels one of the six grand challenges in plasma science and engineering is mastering the art of molding plasmas with lasers yet a gap exists the need for advanced beam control at high power levelsmetapower aims to fill this gap by developing highdamagethreshold metasurfacesthe stateoftheart nanotechnology in structured lightfor highpower lasers these metasurfaces will be integrated in innovative laser beam shapers offering spatiotemporal and vectorial polarization control over laser beams thus making a leap over the state of the art which is currently limited by the lack of advanced highpower opticsthe project will demonstrate the ability to seed and control laserplasma instabilities via reconfigurable vector beams and to create topologycontrolled wakefield acceleration and tunable xray and thztoxuv sources based on spacetime beams with orbiting pulses this marks a paradigm shift in lasermatter interactions enabling new possibilities in fusion energy particle acceleration and radiation sources feasibility is backed by solid preliminary results including successful structured laserplasma simulations a demonstrated scheme for the synthesis of spacetime beams and initial metasurface fabrication resilient to highpower lasersthe implications of metapowers success extend far beyond the groundbreaking objectives of this proposal these transformative technologies may catalyze advancements in quantum plasmas laser material processing high harmonic generation and the development of a new class of polarization plasma optics opening up new horizons in highpower structured lasermatter interactions
the impact of cultural stereotypes in european multilevel policy enforcement

cultural stereotypes are often present in the political and media discourse on european union eu governance eg the lazy greeks the taxdodging italians the stingy dutch and so forth especially when stereotypes are negative they create conflict between national governments fuel euroscepticism among voters and can lead to the discrimination of citizens or member states yet while stereotypes have been studied in political rhetoric and media coverage we know little about their impact on the behaviour of national and eu officials to address this gap eurotypes sets out to investigate how cultural stereotypes impact cooperation and effectiveness in contemporary eu governancethe project is the first of its kind because it studies stereotypes among civil servants as opposed to political elites in the eu who often use stereotypes strategically for electoral gains the focus is on multilevel policy enforcement a new phenomenon in european integration which captures the participation of national and eu civil servants in joint ontheground operations in border control law enforcement cooperation financial supervision etc since they are not socialized in brussels or running for office such officials are much more likely to genuinely display cultural stereotypeseurotypes pushes the frontiers of knowledge in several directions first it applies an original version of qualitative content analysis to identify stereotypes relevant for multilevel policy enforcement second it uses recent developments in experimental research to capture the role of stereotypes among civil servants theoretically the project constructs an innovative account of stereotypes as habits and positions them visvis other explanations of political behaviour interests norms ideas the goal is to show whether and how stereotypes hinder eu cooperation and in the long run establish a comprehensive research agenda on cultural stereotypes in transnational bureaucracies
populism and institutions in latin america a comparative assessment between ecuador and argentina

popinlat scrutinises the oftcontested and undertheorised relationship between populism and institutions through a comparative analysis of the recent leftofcentre processes in ecuador 20072017 and argentina 20032015 this research innovatively brings into the analysis also the postpopulist phase in order to assess the resilience and embeddedness of the institutionality left behind by the populist rule 20172020 and 20152019 respectively and as a result allows to theorise on the possibility and conditions of emergence of a republican populism in this sense the current moment is particularly wellsuited to carry out the proposed research popinlat is situated at the crossroads of different disciplines namely political theory comparative politics and institutional analysis thus using and integrating diverse methodologies popinlat will be based at the university of venice ca foscari with the outgoing phase taking place at the facultad latinoamericana de ciencias sociales flacsoecuador in quito it also envisages a secondment at the london school of economics lse and a short stay at the national university of la matanza in the province of buenos aires by looking at the institutional merits and shortcomings of the two cases the project will cast light on the latin american pink tide as a whole and more importantly provide a novel approach in populism studies which can be applied to the european case as well having an excellent competence in populism and discourse analysis and having worked in the ecuadorian institutions during the period under scrutiny i think of being in a favourable position to successfully complete this research and obtain professional maturity so as to become a leading academic in the field of populism studies
a federated paradigm of realworld data sources utilization for the empowerment of diagnosis prognosis and risk assessment of cardiovascular conditions

in the eu more than 6 million new cardiovascular disease cvd cases are reported yearly along with 18 million related deaths posing a substantial burden on the national healthcare systems and society in general development of effective preventive interventions adopted for each individual and population will not only reduce the overall cost of patient management but will also justify the assertion that cvds could be ultimately prevented and controlled the exploration of existing clinical genetic and realworld data sources can contribute to this direction however several challenges related to the data availability management and processing remain open the 48month project cvdlink aims to tackle these challenges by implementing a privacybydesign europeanwide federated platformasaservice paas for the delivery of effective datadriven humancentric interventions and the advancement of research and management in the cvd domain cvdlink is based on two major offerings 1 the seamless and legally compliant linking and integration secure sharing and automated curation of existing data and 2 a set of ai and dataenabled precision medicine tools and pipelines for better diagnosis risk stratification and treatment in the context of the project 7 different cardiovascular conditions will be examined making use of different retrospective datasets cohort studies and biobanks from 7 counties aiming to set a paradigm of the how heterogeneous data sources can be effectively exploited for building comprehensive aidriven tools in order to bring substantial benefits for health systems patients industry and eu citizens the developed tools will be prospectively validated in 5 countries demonstrating the impact of cvdlink additionally a set of best practices will be generated which along with a costeffectiveness analysis and systematic raising awareness campaigns will promote its wide adoption in the midterm
endtoend cybersecurity to nemo metaos

horizon project 101070118 next generation meta os builds an iotedgecloud continuum in the form of an opensource flexible adaptable and multitechnology metaoperating system nemo aims to unleash the power of artificial intelligence iot to increase european autonomy in data processing and lower co2 footprint leveraging on consortium partners technological excellence along with clear business and exploitation strategies cybernemo builds on top of nemo to add endtoend cybersecurity and trust on iotedgeclouddata computing continuumcybernemo will establish itself as a paradigmshift to support resilience risk preparedness awareness detection and mitigation within critical infrastructures deployments and across supply chains to achieve technology maturity and massive adoption cybernemo will not reinvent the wheel but leverage on existing bydesign byinnovation and bycollaboration zerotrust cybersecurity and privacy protection systems and introduce novel concepts methods tools testing facilities and engagement campaigns to go beyond todays state of the art and create sustainable innovation already evident within the project lifetimecybernemo will offer endtoend and full stack protection ranging from a low level zerotrust network access layer up to a human ai explainable situation perception comprehension protection spcp framework and tools collaborative microcervices auditing certification accreditation and a paneuropean knowledge sharing risk assessment threat analysis and incidents mitigation saam collaborative platform validation and penetration testing will take place in 6 pilots including onelab for integration various critical infrastructures energy water healthcare media distribution agrifood and fintech supply chain along with their crossdomain crossborder federation sustainability and adoption will be offered via the defacto european open source eclipse foundation ecosystem
synergistic combination of immunolabeling and molecular imaging technologies for art research

our cultural heritage is our shared past and should be preserved for future generations in order to preserve an art object it is not only essential to study its structure creation history and significance but it is also necessary to understand its past and current state as well as projected changes in the future in the case of old paintings this requires being able to correlate macroscopic observations with its chemical makeup at the microscopic level timeofflight secondary ion mass spectrometry tofsims is a powerful chemical imaging technique especially suited for heterogeneous systems such as paintings tofsims can simultaneously localize and identify organic and mineral components and has the highest spatial resolution of all the molecular imaging mass spectrometry techniques the submicrometer spatial resolution of tofsims is needed to investigate painting microsamples that consist of submillimeter stacked layers of dried paint that contain both organic and inorganic ingredients case studies published over the last two decades attest to the potential of tofsims in providing information relevant for painting conservation however the resulting imaging datasets are very complex often causing a large proportion to remain unexploited the high energy ion source of the instruments also causes larger biomolecules such as proteins to fragment making it impossible to identify them meanwhile a variety of proteinrich ingredients coexist and age in paintings which means that identifying their nature would be extremely valuable to conservation experts the proposal aims at tackling these weaknesses by developing methods to unambiguously identify the materials found in the heterogeneous microstructures of old paintings samples using a tofsims instrument with novel tandem ms imaging capabilities as well as the development of a tofsimsbased immunohistochemistry relying on metallabeled antibodies to allow for targeted protein imaging
trojandc a breakthrough deeptech innovation for cancer immunotherapy

the challenge cancer remains one of the major challenges to modern medicine affecting oneinthree people in europe available immunotherapies are effective in a limited number of patients and often lose their efficacy due to heterogeneity and lack of tumorantigen presentation despite these shortcomings the global immuneoncology market is one of the fastest growing therapeutics markets large players like merck pfizer and novartis have shown to be keen on acquisitions of highpotential technologies there is thus an urgent need and high demand for innovative costeffective immunotherapies consistently effective in a broader range of cancer patientsthe innovation asgard therapeutics is a preclinical startup company developing innovative cancer immunotherapies based in invivo cell reprogramming the company is led by the scientific cofounder and ceo cristiana pires who together with her cofounders pioneered direct reprogramming to induce antigenpresenting dendritic cells asgard raised a 6m seed round of funding to generate proofofconcept for its lead candidate trojandc a paradigmshifting immunotherapy that reprograms cancer cells into antigenpresenting dendritic cells allowing the presentation of their tumor antigens to the immune system thereby eliciting potent anticancer immunity trojandc has the potential to overcome challenges with current immunotherapies by reinstating cancer immunogenicity the women techeu grant will allow defining a clear roadmap for the indenabling studies and fih clinical trials and creating a comprehensive business plan required to raise series a funding in q4 2023the impact with strong proofofconcept data already obtained an exceptional team of highperforming scientists and a strong syndicate of seasoned vcs asgard therapeutics is in a unique position to develop firstinclass cancer immunotherapy based in invivo reprogramming
the impact of global warming on the soil organic matter decay of world mangroves

the worlds vegetation acts as a large carbon sink absorbing 30 of anthropogenic co2 emissions ecosystems at the interface of terrestrial and oceanic ecosystems including mangroves have been little studied yet mangroves contribute disproportionally to this sink capacity relative to their aerial extent as they have up to ten times higher burial rates than terrestrial forests under global warming it is nevertheless unclear whether mangroves will continue to store carbon and absorb co2 emissions at the same rate or become a net source of co2 this is because higher temperature may accelerate soil biogeochemical processes here i will track the carbon decay in mangrove soils under warmings using a novel combination of mesocosm experiments coupled with isotopic analysis the results will provide the first quantification of soil organic matter som decay under global warming scenarios in mangroves research objective 1ro1 reveal its underlying mechanisms ro2 and potential feedback loop with vegetation ro3 this will be a stepchange in understanding how mangrove carbon stocks and sink capacity will respond to global warming
powdery mildew resistance

plant diseases lower crop yields significantly and thereby threaten foodsecurity worldwide powdery mildew fungi is a severe pathogen on numerous foodcrops generating foodcrops resistant to these fungi would be a major step forward in the continuous fight between plants and pathogens and it would tip the balance in the favor of foodsecurity the proposed project will majorly contribute to this goal by elucidating the immunity related processes occurring upon fungal infection and will allow to develop breeding strategies to heighten plant immunity the barley powdery mildew fungus blumeria hordei causes disease by secreting hundreds of effector proteins into the barley tissue one of the hallmarks of immunity is the formation of a structure called papilla at the site of fungal penetration which limit the damage to the plant evolutionary adapted fungi can easily overcome this however the pathway for secretion of proteins and other components to the papilla is not well understood there is thus a need to increase our understanding of how this secretion process occurs during immunity my host lab has uncovered that the membrane trafficking leading to papilla formation occurs by novel mechanisms not previously studied in plants in the proposed project i will explore this highly complex field by identifying a list of fungal effectors which target this pathway and i will use these effectors to find specific components of it ceramides are predicted to play a role in the secretion of extracellular vesicles during this papilla formation in mammals therefore i will additionally take a targeted approach to characterize their role in plants my strong background and solid trackrecord the expertise and experience of the host supervisor together with the infrastructure and encouraging scientific atmosphere at the host department will synergistically maximise the output of the proposed project and develop and diversify my skills as an independent researcher