Dragon09/odtu_chatbot huggingface dataset:
cryoemnova a cryo electron microscopy hub enabling drug discovery

structural biology is essential for atomiclevel understanding of structurefunction relationships in living systems and increasingly key to providing knowledge structurebased drug discovery while traditionally the method of choice has been xray crystallography in the past seven years dramatic improvements of resolution using cryo electron microscopy cryoem have resulted in cryoem named 2015 nature method of the year and the 2017 nobel prize in chemistry this in turn has had a major impact on the number of cryoem installations in europe publicly deposited structures publications and related knowledge teaching and disseminationportugal is one of the few european countries without this technology that is now changing with the inclusion of cryoem in the portuguese roadmap of research infrastructures 2020 resulting in major funding 25m for the first autoloader cryo electron microscope to be installed in portugal in 2022 coordinated by the cryoempt consortium in whichnova is a node this presents an excellent opportunity for establishing cryoem research and training in portugal and specifically at nova which has expertise using xray crystallography and nmr while expertise in cryoem is lacking resulting in unmet needsthe overall objective of cryoemnova is to establish a sustainable cryoem hub for research and training at nova under the direction of the era chair holder this objective is clearly achievable as prof luecke has experience in setting up cryoem infrastructure leading to highresolution structures of proteins with medicallyrelevant bound inhibitors generating highimpact publications and attracting funding and collaborationsthe operation of advanced electron microscopes and associated vitrification robots coupled with storage computeintensive data analysis requires scientists with indepth knowledge training such talent will have acquired this expertise elsewhere and will need to be recruited to portugal
supramolecular selfreplicating antimicrobials

this project aims to address the urgent need for new antimicrobial agents by developing a conceptually new strategy to damage bacterial membranes with supramolecular fibresdormant nonassembling precursors will accumulate in the membrane of bacteria for in situ switchon of selfassembly and membrane lysis specific metabolic routes of bacteria absent in mammalian cells will be used to transport supramolecular precursors into the membrane of bacteria with full cell specificity once in the membrane precursors will combine to generate selfassembling peptide amphiphiles pas importantly once formed the supramolecular assemblies can catalyse their own synthesis in bacterial membranes causing a dramatic acceleration in pa production and antimicrobial fibrillation this unprecedented antimicrobial design borrows concepts from cooperative selfassembly supramolecular autocatalysis and rational peptide design leading to a selfamplified therapeutic actionthis will be the first selfreplicating antimicrobial that can make copies of itself to boost membrane damage once activated in target pathogens coassembly of pas and their precursors will create catalytic microenvironments by templation of reactive building blocksoverall this project will lay down structural and mechanistic determinants for biological membrane interfacing with targeted and selfreplicating supramolecular nanomaterialsin a broader picture the replicate technology aims to spark a reconceptualisation of drug design by drawing the attention to supramolecular therapeutics which may open new exciting opportunities in biomedicine not accessible from traditional singlemolecule drugs
next generation lidar for automotive and industrial use cases

hybrid lidar systems has invented a patented hybrid technology tof pv for determining distances with light which has enabled us to develop lissa 3d lidar the next generation of 3d solid state flash lidar sensors for enhanced driving safety lissa lidar for smart sensing and automotive represents a revolutionary lidar approach which not only provides a high resolution double vga but also guarantees a very good accuracy level 1cm for a 200m range furthermore lissa 3d applies a multispectral approach to cover more than one area at a time which allows for a better object classification lissa 3d will be of great importance for autonomous driving enabling the detection of small objects at long distances at the usual speed the goal of this project is to equip every moving object in road traffic with our lidar sensor technology so as to raise traffic to a new level of security lissa 3d has a low computational effort enabling the innovation to be offered at a low cost
scaling up early and late effects research in lithuanian childhood cancer survivors through education and twinning

the scarlet scaling up early and late effects research in lithuanian childhood cancer survivors through education and twinning proposal aims to increase scientific excellence and innovation capacity at vilnius university hospital santaros klinikos vulsk and its affiliated entity national cancer institute nci by scaling up research activities in lithuanian childhood cancer survivors ccs the area for twinning was defined based on the emerging importance of survivorship research due to the increasing number of ccs in europe and identified gaps in lithuania the key challenges addressed in the proposal are 1 lack of data on the prevalence of ccs in lithuania exploitable in research initiatives 2 poor transition from paediatric to adult care depriving young ccs over the age of 18 of advantages of surveillance in a research context 3 the need to implement innovative solutions for monitoring and prevention of early and late effects through joint research activities 4 suboptimal competences in management and administration of largescale research projects four researchintensive institutions from 4 european countries will bring to the consortium their specific expertise to address identified shortcomings the proposal aims to build on and exploit current shared research initiatives that will be leveraged to achieve scarlets goal and objectives the twinning exercise will be implemented through secondments of lithuanian staff to the partner premises and engagement in the research activities led by partner institutions organisation of educational events and participation in knowledgeoftransfer meetings as a result of the twinning activities vulsk and nci will improve their research profile and reputation international visibility and attractiveness the expanded networking channels will facilitate lithuanian professionals to join international research groups focused on survivorship research ultimately improving the quality of survival in lithuania
nitrecercat the catalan european researchers night

the catalan european researchers night project consists in a two years proposal for 2024 and 2025 the overall proposal is centred on two main activities the european researchers night ern and researchers at schools rs the wellknown ern will be held on 27 september 2024 and on 26 september 2025 during two years nine partners will bring research and researchers closer to more than 30000 people and 10000 students with nearly 500 activities which will be performed all throughout catalonia a part of ern researchers at schools rs are designed adding a much better and longer interaction of pupils with the research from the catalan institutions 15 schools will become niteducat schools with twoyears of stable collaboration between a team of researchers and the schools the proposal aims at making the public aware about the present missionoriented program of european commission mainly in the idea of how researchers can help to change the world to a better one nitrecercat is divided in two activitiescatalan european researchers night nit europea de la recerca ernola nit catalana de la recerca more than 250 activities for each edition are programmed during friday eveningnight a common el rac deuropa will be allocated in each location together with women in science exhibitionoensopegat amb la recerca during fridaysaturday morning research will be found in everyday locations from markets to museums malls bars etc researchers at school rs oniteducat schools development of 5mediumlongterm projects that promote stable collaboration between a team of researchers and primarysecondary school ola recerca va a lescola special campaigns will be done for research visiting school researcher will encourage students to follow a scientific career otenim experts a list of experts will be offered to primary schools in order to have pupils interacting with researchers in their school project
microbial navigation strategies in ecologically relevant porous media

the navigation of microorganisms in porous environments has received much research attention not only because of its relevance to many ecological medical and technological situations from soil bioremediation to pathogenesis but also as a representative problem in the recently emerging field of active matter taking soil as an example such a hierarchical complex porous structure presents multiple challenges to navigating microorganisms but we still lack a comprehensive mechanistic model that could solve the active navigation problem of microorganisms in such environments in this project i aim to uncover navigation strategies of microorganisms in features of different length scales focusing on their swimming in porous structures and sliding on rough surfaces leveraging a crossdisciplinary approach by combining microfluidics advanced optical microscopy computerassisted image analysis and numerical modeling i expect to extract a general criterion for the optimal spreading by microorganisms in porous media and to discover underlying microbial feedback mechanisms in relation to their porous environments the results of the proposed research will be of interest not only to the fundamental physics of active matter under confinement but also of practical relevance to soil bioremediation biomedical micromotor and antimicrobial surfaces development this project will provide a solid opportunity to build my multidisciplinary research profile and experimental skills ultimately bringing me significantly closer to my career aspirations of being an internationally visible independent researcher
subnanoscale observation of magnetic monopole noise

the magnetic version of the electron the dirac magnetic monopole although predicted to exist has yet to be discovered recently the search for emergent magnetic monopoles in quantum materials has focused on spinice compounds which host magnetic monopoles as emergent quasiparticles even though emergent monopoles have been studied using the toolbox of quantum matter research the long awaited monopole detection is still lacking because of the limited low spatial resolution probes and temperature range of the experiments in this proposal i present a plan to develop a novel concept called scanned spinnoise microscope ssnm and provide a cuttingedge instrument for realising a subnanoscale observation of magnetic monopole noise snoman the ssnm will be designed to operate in a cryogenfree dilution refrigerator to slow down the monopole dynamics and realise the longawaited single monopole detection i aim to undertake this project under the supervision of prof seamus davis at university college cork where all the necessary facilities and expertise are available to achieve the objectives described in this proposal
dramaturgies for languaging developing linguistically sustainable theatre and performance

as european theatre performance and film artists increasingly invite the diverse languages and language practices of a globalised decolonial and postmigratory europe into works across the stage and screen pressing questions arise concerning the representation of minorities dramaturgies for languaging dramalang aims to interrogate the core principles and systems driving european multilingual performance articulate an interdisciplinary methodology for analysing the reproduction of potentially damaging knowledges for minority and lowstatus language speakers and make suggestions for linguistically sustainable dramaturgies to a new multilingual performance network dramalang asks the central research question how are several languages and language practices invited into european dramaturgies to provide access to and legitimise the cultures and knowledges of minoritised and lowstatus language speakers the secondary research questions are how is a lingua franca other than standard english negotiated in interactions and how do the knowledges about minoritised languages and language practices within a european context rearticulate my findings about indigenous and migrant languages in the global south dramalang will take shape at aarhus university au denmark through my observation of multilingual theatre performance and film artists locally in denmark and beyond including germany iceland and romania i will develop an interdisciplinary methodology between sociolinguistics and performance studies for analysing the reproduction of knowledge from multilingual dramaturgies and create a multilingual network of scholars and practitioners across the continent i have pioneered a multilingual methodology like this in the global south au provides the necessary disciplinary guidance through the most specialised dramaturgies department in europe and access to the artistic processes of innovative multilingual european artists through longstanding relationships
chernobyls radioactive pattern in oceanography nuclear fingerprints unraveled through accelerator mass spectrometry

the chronus project aims at providing new insights into the distribution of a complete set of anthropogenic actinides 233u 236u 237np 239pu 240pu 241pu 242pu 244pu in the baltic sea using the ultrasensitive accelerator mass spectrometry ams technique representing a needful step forward in the field of applied nuclear physics to address environmental problems the baltic sea is one of the most contaminated marine environments in the world regarding radioactive materials being exposed by multiple contamination sources in such a way that understanding the different inputs and distribution patterns of the radioactive contaminants has become a major challenge specifically there are still many open questions regarding the distribution of the actinide fallout from the chernobyl accident in 1986 understanding the distribution of radionuclides in this marine environment may be crucial for many environmental applications as well as future radioactivity emergencies this action would include the analysis of the extremely low abundance 233u and 244pu providing novel tools to identify local contamination inputs from the baseline radioactivity levels imposed by the atmospheric nuclear weapon tests 19451980 sediment cores collected from stations covering the whole baltic sea will be used to this end novel sample preparation and ams measurement techniques will be developed to perform all those analyses using the compact 1mv ams system at the centro nacional de aceleradores cna an international centre for accelerator science and technology of the host institution university of seville use spain this action will involve the integration of the researcher dr mercedes lpezlora at the department of atomic molecular and nuclear physics famn and within the very active and multidisciplinary group of applied nuclear physics gfna at the use under the supervision of dr elena chamizo a highrecognised expert in ams techniques and applications
motivations at the automatic and deliberate level to bully

bullying among youth is a major problem with devastating consequences for victims in order to develop effective antibullying programs we have to understand what drives bullying behavior research has mainly focused on striving for high status on the deliberate level but found only weak associations with bullying we thus may be overlooking other status motivations that impact bullying involvement to a much greater extent i therefore propose that not only the motivation to be on top but also the motivation to not dangle at the bottom plays an important role in bullying and supporting bullies in addition as some youth may not be able or willing to truthfully report their deliberate status motivation i propose to examine motivation at the automatic level through implicit and physiological measuresthe aim of the current mad2bully project thus is to uncover the role of status motivation in bullying and following bullies this will be achieved by examining both the reward value of high status and the threat value of low status on the deliberate level as well as on the automatic level to assess these innovative new concepts i will develop and test new stateoftheart measures of status motivation in study 1 in study 2 i will use these measures in a longitudinal multimethod multiinformant design together with assessments of bullying and following behavior and developmental individual and contextual risk and protective factors the insights from this project will radically change our understanding of why youth engage in or support bullying moreover the results from this project will also facilitate bully riskassessments in classrooms and aid the development of effective antibullying and antifollowing interventions that target the right type of status motivation for each type of bullying involvement
demonstrating a highenergy and highpower hybrid battery storage solutions platform for multiple grid services

hihelios aims to deliver a trl 7 modular scalable circularbydesign and safe hybrid energy storage system hess that combines highpower storage capabilities of lfp battery or supercapacitors with highenergy storage capabilities of secondlife nmc batteries to achieve this hihelios will adapt the modular flexible and scalable hess architecture developed in the eu project seabat to grid applications and ev charging support hihelios aims to design the hess based on the shelf battery modules and components and repurposing ev 2nd life battery modules supported by digital models hihelios will custom design and manufacture a hess for 4 usecases of problem owners to solve a reallife hybrid energy storage challenge in hihelios the usecases altogether cover storage services for supporting gridconnected microgrids and islanded grids renewable energy uptake in weak and weak islanded grids and ev charging ev and eboat fastcharging infrastructures as well as ancillary services the hihelios hess contains an innovative bms and physicsbased and datadriven pms ems and cloud platform based in the red and battery passport principles enabling multiple fast services hihelios immediately achieves impact because the 4 hihelios demonstrators will stay inuse at the usecase owners after the project until their end of life hihelios develops a roadmap to trl 9 together with main stakeholders in the energy sector and creates fertile soil for market application with replication studies hihelios will bring long durartion storage 12 hours within reach against storage costs of less than 005kwhcycle by 2030 with a projected cycling life of 5000 cycles via bridge etipsnet and cencenelec the experience emerging from hihelios be used as input to national and eulevel standardization processes hihelios brings together a consortium of 12 partners from 6 countries of which 4 partners are smes and 3 partners are from widening coutries
nextgeneration red cell analysers for bloodbanking transfusion medicine and haematological diagnosis

tissue o2 delivery is essential for life and ratelimiting for activities its maintenance is paramount in medical conditions ranging from critical care to anaemia and a common corrective intervention is blood transfusion drawing an annual demand of 20 units1000 people blood tests are routinely performed 2capitayear in europe to measure surrogates of o2carrying capacity such as haemoglobin content driving a global market worth 10b however current diagnostics cannot measure the speed of o2 release from red blood cells rbcs a parameter as important in determining tissue oxygenation as o2carrying capacity and particularly labile in haematological disease and blood storage to address this unmet need we developed singlecell oxygen saturation imaging a method for tracking o2 release from individual rbcs we demonstrated how o2unloading depends critically on the shape and metabolic state of rbcs providing a gauge of the bloods physiological quality notably our method described slower o2 unloading in spherocytic anaemias and in banked blood units to verify significance we showed how impaired o2 release from stored rbcs reduces oxygenation and respiration in perfused human kidneys endusers of our technology are bloodbanks quality control recipientdonor matching guiding improvements in materials and methods and clinicians novel haematological traits transfusion transplant medicine however further data are required to reaffirm the medical utility and market for our novel parameter teaming with engineers and industry this project will design and assemble three benchtop prototypes of our device for proofofconcept testing in a blood bank uks nhsbt intensive care great ormond st hospital and haematological research peru positive experience will make a compelling case for measuring o2handling our ambition is to produce a nextgeneration haematology analyser as a spinout or for acquisition by a major commercial partner
mediacare empowering caregivers of children with neurodevelopmental disorders through media literacy

in our digitally driven world caregivers of children with neurodevelopmental disorders ndds deal with an avalanche of information while information is more accessible than ever it is also more prone to misinformation adding to the already significant challenges these caregivers face the eu defines misinformation as misleading or false information spread across various media such misinformation often disguised as genuine advice can mislead caregivers affecting their care decisions and steering them away from evidencebased approaches in its commitment to fostering a digitally inclusive society and fight misinformation the eu agenda highlights the role of media literacy enabling individuals to evaluate and critically interpret media messages yet a gap exists no media literacy initiatives are tailored to the unique needs of caregivers of children with ndds mediacare is an interdisciplinary initiative blending media literacy and care research to bridge this gap in mediacare i aspire to develop a novel webbased application to enhance media literacy skills for caregivers of children with ndds mediacare objectives are clear 1 to identify prevalent caregiver media misinformation on ndds and to build the mediacare app to counteract them offering 2 trusted resources 3 aid in discerning information and 4 fostering a digital care community with a usercentered approach and goldstandard methods from a stakeholderengaged review to usability testing and a randomized controlled trial mediacare aligns with the eus digital education action plan promising a pioneering media literacy solution for caregivers the forlipsi department at the university of florence a leader in media literacy research offers me an ideal setting for this project under prof christian tarchis guidance mediacare is expected to empower caregivers enhancing their ability to navigate the media realm confidently and promoting informed evidencebased care decisions