Dragon09/odtu_chatbot huggingface dataset:
cogbooster rebooting psychological research through cognitive neuroscience

cogbooster aims at contributing to closing the research gap in psychology between widening and nonwidening countries by implementing a strong line of research in the area of cognitive neuroscience at the psychology department of the university of coimbra portugal it will do so under the leadership of one of the most respected and highly cited researchers in the fields of psychology and cognitive neuroscience alfonso caramazza importantly for cogbooster alfonso caramazza successfully created and led research centers and departments to excellence in the field of psychology and cognitive neuroscience both in the united states of america as well as in europecogbooster will promote an institutional reform to align the coordinator institution with the cuttingedge psychological research and education currently provided in the psychology departments within nonwidening european countries and in the top psychology departments in the world a close inspection of the major differences between psychology departments in widening and nonwidening countries suggests that the presence of strong and dominant lines of research in cognitive neuroscience marks the divide between these two groups of countries in what concerns psychology to contribute to closing this research gap and increasing research quality and competitiveness at the university of coimbra the institutional reform under cogbooster will focus on 1 attracting talents in the area of cognitive neuroscience to portugal 2 improving research and education by providing top notch training in an area that is central for resolving complex societal challenges and 3 bringing these scientific outputs to society overall the scope of this action extends to the whole system academia target users eg students and the wider community a group of prestigious and influential cognitive neuroscientists will advise on the different steps of the project providing also a clear view for the future of psychology
deep probabilistic logics

neurosymbolic ai nesy is the 3rd wave in ai it wants to answer the key open question in ai as how to combine learning 2nd wave and reasoning 1st wave by integrating logic based ai with deep learning however there is only little understanding of the underlying principles and there exist no widely used machine learning tools that support nesy this makes the development of learning and reasoning systems extremely hard what is urgently needed is a paradigm shift in nesy that focuses on foundations rather than on which system from the alphabetsoup scores best on the latest benchmarksi propose to develop these foundations by identifying key building blocks and demonstrate that they support the integration of knowledge and reasoning into any neural network learning task my methodology is based on the slogan that i have coinedneurosymbolic ai neural probabilistic logical aithis advocates that we need to integrate the two main paradigms for reasoning logic and probability with that for learning neural networks i will exploit many similarities i have identified between statistical relational ai which focuses on probabilistic logics and nesy more specifically i shall develop the foundations of nesy at the conceptual level i shall identify the building blocks of nesy by designing primitives that integrate logical probabilistic and neural networks representations at the semantic level i shall introduce the notion of nesy networks that encompass logic circuits algebraic operators and neural networks as a semantic framework for nesy at the computational level i will show how to exploit nesy networks for inference and learning deeplog is not yet another nesy system but rather a fundamental and operational framework in which a wide variety of nesy systems and applications can be cast and implemented we will develop an opensource software environment and evaluate deeplog s generality and applicability
fully autonomous search tool to investigate directly images and modeling of unexplored stronglenses

the effect of gravitational lensing which means that light of a background source is deflected by a massive object such as a galaxy cluster enables the possibility to probe the universe in multiple aspects including the study of magnified highredshift objects novel cosmological measurements of the hubble constant and of the dark matter and dark energy density parameter values as well as investigations on the formation and evolution of galaxy clusters and their member galaxies in an overdense environment the project aims to develop a fully autonomous search tool to investigate directly images and modeling of unexplored stronglenses fastidious the objectives of the fastidious project are 1 to increase the sample of known strong lensing clusters using deep learning techniques 2 to develop and model with an automated pipeline multiple galaxyscale lenses within clusters to study their formation and evolution and 3 to expand one model to the full cluster to make the first comparison between a stateoftheart model based on image positions only and a model based on the image pixel values directly yielding insight in the effect of constraining the mass parameters through the pixel values and allowing a source surface brightness reconstruction as so far only performed with galaxyscale lenses the fastidious project that i will carry out at the university of milan is an innovative project built to impact several areas within the galaxy evolution and strong lensing fields i will bring extensive experience in strong lens modeling and some unique expertise with deep learning tools applied to various astrophysical aspects this will facilitate the research in the group and the transfer of knowledge and expand my deep learning and modeling experience transferable skills and professional networks carrying out fastidious within a marie skodowskacurie fellowship will enhance the development of my career as a complete and independent leading researcher
the global impact of coastal water contamination on economic development

healthy coastal waters play a critical role for global food security worldwide the ocean sustains the livelihood of more than 3 billion people the vast majority of which live in low and middleincome countries lmics worryingly recent evidence shows that human contamination of coastal waters is having a significant impact on marine life with a large share of communities relying on fishing for survival it is likely that coastal water contamination is already disrupting local socioeconomic development in lmics however knowledge about this phenomenon remains highly limited globcoadev will provide novel insights into the causal effect of coastal water contamination on economic development using a novel approach exploiting exogenous variation in coastal water contamination determined by rivers release and by climate change we will identify this effect for the last five decades and at a global scale for all lmics by gathering a wide array of microlevel datasets ranging from household surveys to satellite imaging and applying advanced microeconometric techniques we will pursue three major objectives 1 to provide the first global evidence of the effect of coastal water contamination on earlychildhood development focusing in particular on the role of nutrition 2 to determine how coastal water contamination affects local economic activities concentrating on the pattern of fishing and on indicators of overall economic development 3 to investigate side effects of coastal water contamination that are impacting local economic development which include changes in political attitudes the insurgence of violence and ruralurban migration globcoadev will not only fill an important gap in the literature but also inform the design of policies protecting the environment as highlighted by uns sustainable development goals knowledge in this area is crucially needed in these challenging times for the ocean
inoperando characterization of antiambipolar mixed conductors

this proposal concerns the fundamental properties of mixed ionelectron conducting polymers these materials are biocompatible and conduct both ions and electrons making them excellent candidates for bioelectronic applications interfacing with living tissue the conductivity of these materials increases under bias by injecting ions and concerted doping of the semiconducting polymer however upon high doping the conductivity can no longer increase but rather decrease the exhibited maximum where any voltage change lowers the conductivity amounts to an antiambipolar response which finds applications in biorealistic artificial neurons the underlying mechanisms however remain unknown in part because of the inherent instability of highly doped polymer semiconductors without understanding the fundamentals of these materials targeted optimization and development are inhibited additional complications arise from the complex environment in which they operate consisting of ions and water their characteristics and response to doping are highly different in these conditions compared to exsitu measurements making inoperando characterization absolutely crucial inoperando characterization is however not straightforward and requires specialized equipmentin this ionic proposal a research plan is described to investigate the fundamentals underlying antiambipolarity by designing and building novel inoperando measurement tools and applying them to a uniquely stable laddertype polymer this unprecedented approach allows for characterizing for the first time the doping interactions throughout the antiambipolar regimeproject ionic marks a major breakthrough in understanding organic semiconductor doping in electrolytes the resulting general structureproperty relations uncovered by the research described in this proposal will enable an intelligent design of material systems for exciting applications in bioelectronic interfacing and biomimicking circuitry
biomimetic engineered chordae tendineae for valve repair and regeneration

the human heart is among those organs suffering from a limited capacity to selfregenerate heart diseases continue to be a leading cause of mortality with suboptimal therapeutic options thus deploying new therapeutic strategies for tissue repair is a primary objective in modern cardiac medicine valvular heart diseases such as those related to the mitral valve mv are the leading causes of cardiovascular morbidity and mortality worldwide affecting 51 of the 65 years old population in particular mv regurgitation one of the most common valvopathies affects over 24 million people worldwide since the fundamental nature of mv regurgitation is mechanical caused by physical irreversible damage to the restraining force structures of the valvular apparatus the only effective treatment is limited to the surgical approaches that include mv repair or replacement however when the regurgitation is due to chordae tendinae ct elongation or rupture several studies have demonstrated the substantial advantages of mv repair using a substitute for the damaged ct vs mv replacement currently the expanded polytetrafluoroethylene eptfe has become the standard approach in ct repairreplacement1 however several complications rupture calcification detachment fibrosis and slippage have been observed hence there continues to be an urgent need to develop better mv repair techniques that are simple effective and durable in this proposal we intend to further advance and validate biochord the first ever polymeric bioengineered regenerative ct designed to first repair the mv by replacing the diseased ct providing mechanical support to the valvular apparatus then to be restored by the patient tissue progressively becoming a functional tendonlike structure that as a native ct while connecting the valve leaflet to the papillary muscle will sustain the valvular apparatus with blood and nutrients
effects of spinorbit coupling on superconducting pairing interactions

superconductors with spinorbit coupling exhibit many fascinating properties including abnormally high upper critical fields and possible topological excitations these effects are recognized as originating from the impact of spinorbit coupling on the cooper pair wave function in contrast how spinorbit coupling affects the superconducting pairing interactions the glue that binds electrons together in cooper pairs remains an open question this is particularly relevant in unconventional superconductors as the interplay between spinorbit coupling and electronically mediated superconducting pairing interactions may give rise to novel feedback effects that boost the efficacy of the pairing interactionsin this project i will adopt a dualpronged approach to study the interplay between spinorbit coupling and interactions 1 develop a generalized eliashberg theory to account for feedback effects in spinorbit coupled systems and 2 implement fermionic renormalization group methods and determinant quantum monte carlo simulations to map out the interplay between electronic correlations and spinorbit couplingthe main results of supersoc will be establishing how spinorbit coupling may fundamentally reshape the pairing interactions and modify the associated superconducting instabilities of unconventional superconductors developing a framework for studying these feedback effects in materialspecific models and employing this to understand the phase diagrams of unconventional spinorbit coupled superconductors demonstrating how the interplay between electronic correlations and spinorbit coupling leads to anisotropic interactions that alter the shape of the electronic phase diagram and may enhance pairingthese achievements pave the way for identifying the nature and origin of unconventional superconductivity in spinorbit coupled systems and enable a determination of the electronic phase diagrams in such systems
metabolismdriven division of minimal celllike systems

building a synthetic cell from molecular components is one of the grand scientific and intellectual challenges of the 21st century and requires interdisciplinary skillsets to design and integrate biochemical modules at different levels of hierarchy great progress has been made in the fundamental understanding and reconstitution of key features such as metabolic reaction networks and replication machinery however their successful synergistic integration in minimal cells still lags far behind due to often largely different experimental approaches metadivide will bring together two groups of worldleading scientists with complementary expertise in biochemistry and biophysics to address this gap poolman and schwille will combine their mastery of membrane systems and protein machineries to establish a blueprint for coupling metabolic networks to cellular modules for spatiotemporal regulation and forceinduction for division by this we aim to reconstitute in a minimal system one of the most stunning and central features of cellular life the autonomous division of protocellular compartments by encapsulated selforganizing macromolecular machinery driven by a selfsustaining energy metabolism we will test our hypothesis that the otherwise separately researched features of life metabolism cell division and genome segregation are mechanistically linked in the emergence of cellular life besides the great technical advance in synthetic biology this will be a huge accomplishment in the understanding of biological mechanisms in todays organisms which in living cells are often obscured by their immense molecular complexity moreover our new fundamental insights on the main principles underlying cellular life will advance applicationdriven research by elucidating the mechanisms of outofequilibrium reaction networks and cell division we will obtain insight that may inform the future development of generic small molecules to curb bacterial proliferation
circular economy resource information system

the rising demand and limited supply of critical raw materials crms impair the ability to rapidly adopt technological change toward green and sustainable technologies which directly affect the resilience of eu industries seeking to achieve green deal objectives for an equitable zeroemission and digitalized europe in response to these challenges the european commission aims to minimize the loss of secondary raw materials srm and optimize their reuse across value chains cerise will develop and pilot an integrated framework and an ensuing resource information system to identify optimal solutions for the effective reuse recovery andor recycling of materials by a defining a set of criteria re criteria to evaluate the extent to which products and embedded components can be reused repaired refurbished andor recycled b incorporating information on re criteria and material composition of products into the digital product passport dpp to enable traceability of materials in the supply chain c integrating dpp with information on the environmental footprint of products pef socioeconomic and environmental see impacts of re processes d enabling confidential and anonymized information sharing among actors throughout value chains e providing openaccess software application to disseminate information on the assessment of re criteria pef and see impacts of products to all stakeholders including consumers and policymakers the results will be piloted on four case studies cerise will contribute to bridging the digital divide in society by supplying affordable secondhand ict devices and supporting access to digital education and job opportunities ultimately cerise will foster a dynamic ecosystem geared toward prolonging the use of materials in the economy and stimulating circular business models to reduce waste generation while optimizing the reuse of srms
in vivo crisprbased nanoplatform for gene editing a new disruptive avenue for noninvasive treatment of genetic brain diseases

genetic brain diseases are among the most devastating and fatal diseases typically having only palliative treatments and no cure the revolutionary crisprcas gene editing technology provides a new horizon and enormous potential for treating such diseases however efficient and safe delivery of crispr machinery to diseased cells within the brain is one of the greatest challenges in medicine today here i plan to expand far beyond the stateoftheart and propose a gamechanger approach for this unmet need a breakthrough nanoplatform which will transform crispr into a clinicallyrelevant noninvasive technology enabling therapeutic genome editing in the brain our proofofconcept results serve as the baseline of this pioneering research project revealing the exceptional capabilities of insulin as a key to overcoming formidable brain and cell barriers we will harness these unique abilities within the novel nanoplatform and shuttle crispr machinery across the bloodbrain barrier transport it into deep brain regions and mediate its successful entry into specific diseased brain cells leading to highly effective gene editing the nanoplatform will be designed to meet key criteria for noninvasive safe and efficient delivery of crispr to the brain while conferring a high degree of modularity and compositional heterogeneity thus providing both universal and patientspecific components the nanoplatform will be thoroughly investigated in primary brain cells 3d organoids and casestudies of monogenic brain disease models this comprehensive research will culminate with a universal and modular braincrispr nanoplatform and delineate design principles for its precise tailoring to specific needs of different brain diseases overall this research will provide indepth fundamental knowledge and have a transformative effect on applying crispr in brain whilst opening a wide array of possibilities with broader impact on genetic brain therapy and beyond
creation of an excellence group to foster the design of affordable sustainable and healthy foods

the rapid growth of the global population is pressuring the agrifood sector to deliver in a sustainable manner healthy tasty and affordable foods which are aligned with the consumer dietary preferences in response to this thrive will establish an ambitious era chair programme in sustainable food structuring technologies at the centre for biotechnology and fine chemistry cbqf of universidade catlica portuguesa under the leadership of professor llia ahrn a worldleading researcher in the field thrive will enhance the scientific excellence and innovation capacity of cbqf and portugal through the creation of an interdisciplinary research group that will support the development of new processes for the structural design of future sustainable and healthy foods a novel forktofarm approach involving not only researchers but also consumers producers retailers and policimakers will be used to foster cocreation while promoting strategic interactions with relevant international and intersectoral stakeholders to increase thrives impact on the agrifood systemsthe proposed activities will contribute to the green transition of the agrifood sector a strategic area for portugal and europe while ensuring that new food product designs are both technically feasible and tailored to customers needs and preferences in addition thrives mission transcends research encompassing a commitment to drive structural changes and support measures to make cbqfs performance thrive by integrating the eu charter and code for researchers developing a new integrative research strategy including the creation of a living lab establishing a robust stakeholder platform and boosting cbqfs research management capacity thrive aspires to cultivate an ecosystem conducive to ideation and innovation thus placing cbqf as an international hub at the forefront of ri in food science with a strong impact on the regional national and european systems
highquality graphene supports for microspectroscopic techniques

transmission electron microscopy tem is a powerful technique to fully characterise the local structure of a broad range of materials due to many recent hardware advances the quality of tem measurements is nowadays ultimately determined by the sample supports surprisingly though their importance has been majorly overlooked so far the many benefits of graphene layers as a support have been wellrecognised by the community but commercial graphene grids show poor coverage and are dominated by unwanted residues and cu nanoparticles from the preparation process consequently commercial graphene grids currently correspond to merely 1 of the grids used a solution to this problem is a novel protocol to produce highquality graphene grids developed within my ongoing erc consolidator grant realnano a headtohead comparison with the stateoftheart demonstrates the superior quality of the hypergraph grids moreover our ongoing market survey with leading groups in both materials and life science indicates a very strong need for graphene grids that yield high and constant quality therefore the overall aim of this poc is to deliver our hypergraph supports to the tem community our beachhead market to reach this goal our methodology is based on further product development reproducibility costefficiency and shelflife exploration of other possible applications and business planning in this manner we aim to increase the technology readiness level for hypergraph from 4 to 7 and the and commercial readiness level from 4 to 6 feeling the pain related to the poor quality of tem supports as an end user every day i am convinced that valorisation of our technology can fill a crucial void in the tem value chain in this manner hypergraph will enable characterisation and further development of new generations of nano and biomaterials with applications in fields as broad as catalysis medicine protein research viral infections and energy