Dragon09/odtu_chatbot huggingface dataset:
induction of neuromuscular plasticity for natural motor rehabilitation

neurorehabilitation technologies aim to promote functional neural plasticity in patients suffering from neuromuscular disabilities noninvasive systems for the magnetic or electrical stimulation of the neural pathways are particularly promising for interfacing directly with the nervous system of the patients and restoring coordinated movements despise these potentials current neurorehabilitation systems have still significant limitations since they usually employ stimulation protocols based on specific assumptions on cortical and spinal connectivity an efficient way to overcome this problem will be to estimate neural adaptations during the rehabilitation procedure and optimize its parameters directly the project inception aims to develop innovative methods to estimate patterns of neural connectivity from the decomposition of highdensity surface emg signals and induce reorganization of the connectivity of motoneuron populations innervating the main arm and shoulder muscles using magnetic and electrical stimulation of cortical and sensory pathways the revolutionary concept of the project will be to implant a signature of motoneuron correlation to promote changes in neural connectivity and therefore functional recovery of movements in chronic stroke individuals and breast cancer survivors the approach will provide the possibility to better understand the mechanisms of neuroplasticity in the central nervous system and define efficient stimulation protocols to reestablish natural connectivity in the motoneuron pools of patient individuals by combining multidisciplinary contributions from the fields of neurorehabilitation computational neuroscience biomedical signal processing and neurophysiology the project inception aims to produce substantial progress toward a better understanding of the adaptation mechanisms involved in the connectivity of spinal motor neurons and its use in the next generation of neurorehabilitation systems
thermochemical storage utilization enabling data centre seasonal energy recovery

worldwide data centers dc are estimated to account for 1 to 2 of electricity usage regarding the european context it is expected that data centres will account for 985 twhyear in 2030 so it is evident that there is an important potential to recover waste heat from the cooling processes of dcs the thunder project aims to overcome existing barriers hampering a wide adoption of dcs waste heat recovery strategies providing an innovative efficient and cost attractive seasonal thermal storage based on thermochemical materials thunder solutions stretch across the value chain data centre innovative storage providers heat pump manufacturers and district energy company operators the thunder solutions will be validated in field conditions at the demosite in bulgaria where the practice of whr from dc is not widely diffused thus boosting the market also in those areas deepened replicability assessment will be done and prefeasibility analysis developed in 10 further demosites across all over europe codesign and training workshops will be organized at the replicability identified sites to promote stakeholders engagement and social awareness thus unlocking barriers and make it real thunder replication
solutions for mitigating climateinduced health treaths

in spite of the ambitious mitigation efforts set out globally and addressed by initiatives of the european commission climate change is under way and intensifying ipcc 2021 according to who estimates the direct damage by impacts of climate change on human health is between 17 and 4 billion by 2030 the aim and ambition of trigger are to deepen current understanding of the linkage between climate health and ecosystems exposome framework and to use this knowledge to advance society uptake at personal and policy level to meet the ambition trigger will commit an interdisciplinary consortium of 22 partners in 15 countries that will develop an outreaching clinical study composed by a multidimensional approach that capitalizes also on existing retrospective studies and will build an international climate service for global health protection in line with copernicus initiatives trigger strategy is grounded on three pillars i transdisciplinary investigations to build up systemic knowledge ii integration and usability of research results and iii development of practical knowhow and workable tools to monitor predict and mitigate risks for human health connected to climate change the proposal is designed around the creation of 5 newly conceived climatehealth connection labs in europe that engage citizens practitioners and policymakers in a cocreation process the approach will target areas exposed to adverse impacts of climate change such as increased heat waves air pollution and droughts and will address key health issues such as cardiovascular diseases respiratory diseases and uv exposure by overcoming heterogeneous technological and methodological challenges trigger will provide exploitable tools to strengthen surveillance mechanisms and risk assessment to translate robust evidence of climateenvironmenthealth relationships into actionable information and guidelines to identify and prioritise costeffective policies and actions
harnessing stromal fibroblasts to reduce resistance and improve colon cancer therapeutics

refractory tumors and emergence of drug resistance are the most important challenges in cancer therapeutics the noncancerous determinants of therapeutic response and particularly the role of the tumor microenvironment tme in resistance are poorly understood i previously described the crucial role of cancerassociated fibroblasts cafs in key tumorigenic processes including matrix remodeling cancer cell invasion and growth importantly these aggressive caf phenotypes are controlled by mechanical reprogramming and mechanotransduction pathways within therapeutic resistance contexts i hypothesize that preexistent and therapyinduced aberrant activation of mechanotransduction signaling in cafs leads to the generation of refractory tmes affecting cancer cell signaling and the behavior of accessory stromal cells such as endothelial and immune cells as a result tumors will present i abnormal vasculature associated with reduced drug perfusion and chemotherapy efficacy ii increased production of prosurvival signals affecting targeted therapy and iii inactivation of cytolytic t cells and reduced responses to immunotherapy i propose that cafbased biomarkers will improve our capacity to identify patients most likely to respond to these therapeutics in addition targeting mechanotransduction in cafs will significantly increase efficacy in nonresponders focusing in colorectal cancer i will use patientderived cafs as a tractable system and organonchip in vitro and preclinical models of cafmediated resistance and combinatorial chemistry to systematically elucidate the molecular and biological features conferring cafs their privileged therapyresistance properties this will illuminate novel and general mechanisms whereby tme characteristics influence tumorigenesis and inform the development of refined biomarkers to stratify patients and next generation combinatorial therapies including anticaf therapies with reduced risk of recurrence
molecular and functional characterisation of znucleic acidinduced signalling

nucleic acids are potent activators of an immune response znucleic acids are poorly defined and thermodynamically unstable conformers of doublestranded rnadna helices recently others and our group showed that znucleic acids are recognised by the nucleic acid sensor zbp1 thereby inducing an antiviral immune response activation of zbp1 has also been shown to induce anticancer immunity and it is becoming clear that chronic engagement of zbp1 by endogenous znucleic acids causes autoinflammatory pathology on top of that a remarkably diverse set of cellular insults ranging from pathogens and chemicals to genetic mutations trigger zbp1 activation despite its relevance in these important pathophysiological events knowledge on the fundamental principles that govern znucleic acidinduced zbp1 signalling is lacking i here propose that zbp1 perceives these widely different disturbances in cellular physiology by detecting the increased intracellular concentrations of znucleic acids based on a newly developed zbp1 activation model and using nanopore sequencing structural biology and chemical or genetic perturbation methods we will i characterise the molecular mechanisms that regulate znucleic acid levels ii determine the biophysical determinants of zbp1 activation iii map the zbp1 downstream signalling network and iv functionally validate our novel findings in cellular and in vivo models of zbp1 activationthe resulting detailed mechanistic understanding of zbp1 function from single molecule to organism will enable us to develop future strategies for therapeutic interference with zbp1mediated immune responses either negatively to resolve autoinflammation or positively to promote antiviral or anticancer immunity
timeliness of information in smart grids networks

timesmart project will investigate the applicability of the novel age of information metric in smart grid networks while the metric has become a valuable tool for measuring the systems performance its practical value and impact in the realtime system are left unanswered this project seeks to remedy that by applying the metric to a system in which the timing of collected data currently measured through jitter or latency profoundly impacts management and control the aoi offers a new perspective on how the system should collect and process information as such decisions are also based on the context of processed informationtheir semantic nature in turn the new approach can offer an innovative way of improving the efficiency of renewable electrical energy supply and electrical loads by taking advantage of the available edge infrastructure this project aims to adopt the aoi metric in smart grid networks to improve the energy transmission efficiency achievable through more timely collected information to save energythe proposed research will be conducted by dr jernej hribar and supervised by prof mihael mohori and dr carolina fortuna from institut joef stefan the applicant will also undertake a nonacademic placement at comsensus under the supervision of dr andrej ampa
climate impacts of a hydrogen economy the pathway to knowledge

the hyway project will be the most comprehensive study on environmental effects of largescale hydrogen usage to date hyway is led by a team of experienced scientists who have already conducted extensive research on the climate effects of hydrogen to fully understand the climate effect of hydrogen emissions hyway will constrain the hydrogen budget by novel work on surface emissions measurements of leaks and soil uptake fluxes and application of a global atmospheric model ensemble combined with observations to quantify the atmospheric sources and sinks of hydrogen to improve monitoring tools for hydrogen leakages hyway will develop novel emission modelling and installationlevel emission measurements we will measure the hydrogen soil sink using flux chambers and instrumented drones and we will use this knowledge to improve processbased models of the sink the global warming potential of hydrogen and its effective radiative forcing will be quantified including the component contributions from methane ozone stratospheric water vapour and aerosols hyway will also quantify several environmental effects associated with hydrogen emissions such as stratospheric ozone depletion and air pollution hyway will build on existing methods to create realistic future scenarios to fully explore the climate and environmental impacts of a hydrogen economy including coemissions and associated reductions in fossil fuelrelated emissions hyway includes a large advisory board of industry partners several of them from established hydrogen collaborations the advisory board will assist in estimating hydrogen leakage rates and in establishing realistic scenarios for a future hydrogen economy by evaluating the potential climate and environmental impacts of a hydrogen economy hyway will provide critical information to policymakers and stakeholders allowing them to make informed decisions about the role of hydrogen in the transition to a lowcarbon economy
sglt2 inhibition for cardiovascular endpoint reduction in hypertension sglt2hype

hypertension htn is a leading cause of cardiovascular disease cvd affecting 80 million eu citizens and 50 of people aged 65 years resulting in 1 million deaths per year predominantly from cvd and chronic kidney disease ckd the damage done by cvd costs almost 300 billion annually in the eu alone despite existing therapies patients with htn still face substantial risks due to preexisting and ongoing endorgan damage due in part to inadequate blood pressure bp control sglt2 inhibitors sglt2i are recommended for both type2 diabetes and heart failure to reduce morbidity and mortality sglt2i reduce bp and might also improve outcomes for htn by reducing endorgan damage through diverse other actions however confirmation that sglt2i are clinically useful for the management of htn is required to change guidelines and clinical practice therefore we designed a multicentre doubleblind randomised placebocontrolled trial sglt2hype comparing the effects of dapagliflozin to placebo in people with inadequately controlled htn aged 65 years and with at least one other cvd or risk factor the primary endpoint is a composite of cvd and ckd morbidity and mortality a key secondary endpoint assesses quality of life with 5792 participants assuming an annual placebo event rate of 25 compared to 2 with sglt2i a 3year recruitment period and a minimum followup period of 4 years 7 years in total the trial has 80 power for p005 twosided this guidelinerelevant trial will inform guidelines and practice and may introduce a new therapeutic class for htn enhancing the current standard of care for an extremely common treatable cause of cvdckd to reduce or prevent morbidity disability and death by engaging with key stakeholders the trial aims to not only revolutionize care and wellbeing but also to achieve substantial healthcare cost savings 10 billion annually across the eu and prevent 250000 deaths globally each year
reaching excellence in hyperspectral remote sensing

the reaching excellence in hyperspectral remote sensing expert twinning proposal aims at improving the excellence capacity and resources of romanian space agency rosa in hyperspectral hs remote sensing through knowledge and best practices transfer by italian space agency asi and german aerospace center dlr ie the internationally leading space agencies on satellite airborne and groundbased hs technologies including the recent prisma enmap and desis missions the project represents an excellent opportunity to broaden rosas activities which in turn will increase the involvement of both national and european stakeholders in its research and innovation tasks the concept of expert is underpinned by three fundamental pillars research coordination and support measures and research management and administration skills in accordance with the objectives of the proposal specifically the project is focused on capacity building in hs data analysis and ground measurement campaigns achieved through specific courses seminars short staff exchanges and field campaigns organized under the guidance of asi and dlr considering the clear interdisciplinarity of expert focus will be given on rosas main areas of expertise and applications including agriculture cultural heritage application and mineralogy these will also be the topics of joint research in the second part of the project where rosa will organize autonomously ground measurement field campaigns and use the data jointly with simultaneous acquisitions of enmap prisma and desis data provided by asi and dlr furthermore special attention will be given to strengthening the research management capacities and administrative skills of rosa together with knowledge advancement research infrastructure development joint networking and outreach activities by the consortium members these will lead to improving the impact and visibility of rosa within the eu
attosecond nanoscopy of electron dynamics instrongly correlated materials

in 1929 one year after the formulation of his worldfamous equation paul dirac wrote that the fundamental laws of a large part of physics and the whole of chemistry are thus completely known but lead to equations that are too complex to be solved while dirac was referring to analytical solutions to his equation numerical approaches have made tremendous progress over the past century nonetheless the socalled strongly correlated materials continue to defy a common experimental and computational access to some of their intriguing exotic properties in solidsin this proposal i will investigate correlated transitionmetal oxides which undergo a phase transition upon external perturbation such as temperature pressure strain or laser excitation i will develop a unique tabletop ultrafast softxray absorption and holographic imaging experiment the measurements will follow the attosecond to picosecond dynamic switching between metallic and insulating phases after laser excitation of transition metal oxides with elementspecific absorption measurements and simultaneously spatially resolve the ultrafast emerging nanometer texture of the phase transition the unprecedented measurement of attosecond nanoscale dynamics will enable to unambiguously identify the mechanism and ultimate speed of phase transitionsi will use the fundamental insight from attosecond nanoscopy to test the hypothesis that structural and electronic imts coexist and can be steered through both sample engineering and attosecond lightfield control which will pave the way towards phz oxide electronics controlling the currently absent spatial uniformity of phase transitions on the nanoscale and the concomitant orderofmagnitude resistivity changes are key ingredients to guide transitionmetal oxides towards their longheralded usage in future oxide electronics as thinfilm transistors which will finally enable reram memory to enter highvolume manufacturing
the cardiac neurovascular interface in aging

aging is a major risk factor for impaired cardiovascular health the aging myocardium is characterized by endothelial cell dysfunction diastolic and systolic impairment increased hypertrophy and fibrosis and electrophysiological alterations that predisposes the elderly to arrhythmic risk the mechanism of ageassociated pathophysiological alterations are incompletely understood in preliminary data we report that aging is associated with a decline in axon density in the heart since vessels align with nerves and this interplay is critical for tissue homeostasis in other organs we postulate that an impairment of the neurovascular interface in the aging heart may contribute to ageassociated pathologies to address this hypothesis we will first characterise axon extension and patterning of different nerve fibres in the heart second we will decipher the underlying mechanisms mediating the reduction of axon density in the aging heart based on preliminary data documenting an induction of the repulsive semaphorin 3a sema3a in endothelial cells of the aging heart we will address if endothelial sema3a mediates the effect third we will determine the consequences of reduced neuron density we will i study electrical stability and arrhythmias ii we will explore the nerve secretome aiming to identify paracrine signals that possibly control cardiac tissue homeostasis and ageassociated alterations iii we will assess the crosstalk of neurons with ageassociated cardiac inflammation finally we will determine whether senescence may contribute to neurovascular alterations during aging we will extend preliminary data suggesting that senolytics interfere with the ageinduced decline in axon density together these data will decipher the so far unexplored role of the neurovascular interaction in the aging heart we believe that restoring or preserving a functional crosstalk between neurons and the vasculature may contribute to healthy cardiac aging
reconciling peace international coalitions for peace in the era of decolonization 19181970

how did peace movements act upon the interlinked processes of decolonization and the cold war and how did these processes in turn impact the ability of peace movements to come together in large international organizations for peace reconpax studies attempts to build large international coalitions for peace in the period 19181970 it departs from the assumption that while peace activists reached out to each other in pursuit of shared goals they did not necessarily share common methods attempts to include organizations from the decolonizing world in existing international bodies brought different understandings of peace work to the surface in short the necessary preconditions for a peaceful international order were both locally and historically contingentthis project brings historical depth to an issue of continuing relevance to the international order it challenges the historiographical focus on the cold war as the primary factor in the development of international peace organizations it does so in two ways by taking a longue dure perspective that incorporates precedents set by peace movements after the first world war and by turning the lens on decolonization rather than on superpower competition reconpax hypothesizes that the challenges posed by decolonization and the end of empire were the dominant drivers of success and failure in building international coalitions for peace a fourperson team consisting of two phd researchers a postdoc and the pi will study these dynamics from four different complementary vantage points all divisive issues in the peace organizations of the postwar decades conscientious objection to military service in the decolonizing world phd1 nonproliferation in the decolonizing world phd2 peace in maternalist thought postdoc and peace in antiimperialist thought pi together they will reveal how these issues shaped the possibilities and constraints of international coalition building
phages against mdr enterococcus faecium

due to its multidrug resistance mdr enterococcus faecium efm poses a challenge to the healthcare system and renders most standard antibiotics useless bacteriophage phage therapy has resurfaced as a treatment strategy for bacterial infections due to increasing antibiotic resistance its advantages include specificity low side effects and production costs especially when used in combination with standardofcare antibiotics phage therapy has been successful in compassionate use but its wider implementation is hindered by a lack of knowledge on which antibiotics phages synergize and the mechanisms behind remain elusive our project is unique in that it aims to enable the use of conventional antibiotics in mdr efm through phages we want to explore which antibiotic classes phages synergize with which survival strategies efm uses against phages and how host factors influence the ability of the antibioticphage combination to kill efmfirst we will investigate phages interaction with different antibiotic classes against efm we will explore the dynamics of phageantibiotic combinations and whether they are additive synergistic or antagonisticsecond potential phage survival strategies of efm will be investigated additionally membrane vesicles will be investigated as a potential survival strategy against phages and their ability to act as a decoy and protect the bacterium from phages will be studiedthird we will investigate the impact of host factors on the phageantibiotic killing of efm to see whether they can enhance or suppress the phageantibiotic killingthis approach will provide a deeper understanding of the phagesantibiotic interaction against mdr efm strains as well as potential survival systems of efm which may also shed light on possible mitigation strategies overall this approach has the potential to enable the use of standardofcare drugs against mdr bacterial infections in general