Dragon09/odtu_chatbot huggingface dataset:
creating an orthogonal gate to the brain

many impairing illnesses raging from metastatic cancers to neurodegenerative diseases affect the brain unfortunately delivery of therapeutics to the brain is highly challenging due to the bloodbrain barrier bbb despite decades of research no safe and efficient strategy to overcome this barrier has reached clinical application here we propose a concept that will revolutionize brain transport creating a new orthogonal receptor to mediate transport across the bbb numerous molecules have been developed to achieve brain delivery via receptormediated transport however delivery is very limited presumably because no receptor combines 3 key features high transport efficiency high expression on the bbb and low expression on peripheral tissues this results into peripheral tissues acting as a sink and dramatically lowering the therapeutic index of drugs aimed for the brain the greatest limitation of current efforts is trying to solve both selectivity and efficient transport in a single delivery vehicle our unprecedented approach is based on dissecting this problem in two increasing transport efficiency with the new orthogonal receptor obgate and addressing selectivity with a highly efficient targeted vehicle to express the receptor only at the bbb since this receptor will not bind any endogenous ligand its properties and intercellular trafficking can be engineered with minimal alteration of brain homeostasis this will enable to unravel the key determinants of bbb transport and to build an ideal transport system selective expression of this receptor in the brain endothelium will be achieved by engineering a gene delivery nanocarrier mimicking the twostage viral entry into bbb cells as an example to prove the efficiency of our system we will aim to deliver biotherapeutics for the treatment of brain metastatic breast cancer overall we will open a new gate to the brain that is poised to be paradigmbreaking in the treatment of neurological diseases
spacebased composite adsb and multilaterarion system validation through scalable simulations

satera will propose and validate an integrity estimator for spacebased adsb systems based on crosschecking positions reported in adsb messages with position estimations provided by spacebased mlat systems to reach this goal satera will apply a stepped approach starting by the definition of an initial osed providing a highlevel operational description at system level identifying all the involved stakeholders and detailing the cns equipage of the fleet and the available air traffic services then satera will adapt the system architecture described in the ed142a for a composite groundbased surveillance system providing adsb and wam surveillance to cope with the particularities of a spacebased system next the research team will develop theoretical models to assess and benchmark the proposed system architecture leading to a full list of functional requirements and interfaces description that will be captured in a functional description document satera will also adapt for a spacebased system the performance requirements it has to meet according to the ed142a for enrlowmediumhigh traffic densities afterwards satera will develop a system performance prediction tool to compute the theoretical performance of a mlat system whose receiving stations are onboard of a constellation of leo small satellites this tool will take into consideration all the error sources that can affect the mlat system performance and will be used to update the initial osed if needed and system architecture and to select the most suitable constellation for validating the satera solution at trl2 using an endtoend system evaluation tool that will be developed by the research team as an evolution of the system performance prediction tool the trl2 validation will consist of several validation exercises addressing the provision of composite spacebased adsbmlat surveillance in the eursam and nat corridors for realistic traffic
clean energy transition partnership

the clean energy transition partnership cetp is a transnational initiative on joint rtdi programming to boost and accelerate the energy transition building upon regional and national rtdi funding programmesit aims to empower the energy transition and contribute to the eus goal of becoming the first climateneutral continent by 2050 by pooling national and regional rdti funding for a broad variety of technologies and system solutions required to make the transition it will foster transnational innovation ecosystems from the very local and regional level up to the transnational european level thus overcoming a fragmented european landscape the cetp is aiming to enable 70 national and regional rdti programme owners and managers from 32 countries to align their priorities and implement annual joint calls from 2022 to 2027 original first proposal as published by the ec on cordis actually 30 countries and 55 programme owners and managers formally participate in this initial grant agreement they also organise joint accompanying activities to enable a dynamic learning process extract strategic knowledge knowledge community and maximise the impact impact network to accelerate the upscaling replication and market diffusion of innovative solutions this will foster the uptake of costeffective clean energy technologiesthe common vision of the cetp is already manifested in its strategic research and innovation agenda sria that has been cocreated in a broad engagement process during 2020 together with the involved countries the eu setplan implementation workin groups and etips all energy relevant eranets as well as the eera joint programmes over 500 editors coauthors commenters and discussants the sria was endorsed together with the european commission dg rtd and ener in november 2020 this articulates the common goal of 1 building a transnational transformative joint programming platform 2 developing and demonstrating technology and solutions for the transition of energy systems and finally 3 building innovation ecosystems that support capacity building at all levels
quantifying islamic law in the modern state sharia in moroccan courts 19122012

this mscapfef project proposal investigates the role of sharia islamic law in the contemporary national legal systems focusingon the case of morocco from 19132012 i combine digital humanities methods with qualitative text analysis to trace the conceptual and functional development of sharia i hypothesize that sharias practical function is best understood through court cases rather than classical prescriptions or state legislation of it alone using approximately 1400 sharia appeals court records collected during my doctoral fieldwork i will construct a multivariable sharia court database the database will be a firstofitskind data record of case variables including appellate decisions evidence types geography and source material citation with this database and the conclusions i derive from it i will embark on a series of publication scholarly collaboration and public outreach efforts on sharias contemporary role in the world the publications include three scholarly articles a collected volume on islam and colonialism based on a conference that i organize and a book proposal based on this research public outreach efforts include a public lecture series on colonial islamic legal practice syllabi on understanding colonialism and understanding contemporary islam for high school students and an online presence sharing results and analysis finally the database will be published open access online at the end of the fellowship both to aide researchers or stakeholders and to propose a model for assessing sharia courts worldwide as many state governments ngos and legal scholars continue debating sharias role in the twentyfirst century my project will present a strong historically grounded paradigm of sharias contemporary function in state courts
giving rural actors novel data and reuseable tools to lead public action in rural areas

representing 30 of its population and over 80 of its territory eu rural areas are facing simultaneous demographic climate economic social and environmental changes which affect their characteristics and metabolisms responding to these challenges requires a precise understanding of what rural areas are and what rural communities are facing nowadays definitions of rural areas tend to lean on population density or size they do not provide sufficient insights into the dynamics drivers and fluidity of contemporary diverse ruralurban relations and identities that characterize ruralities across europe despite the increasing acknowledgement that rural areas are diverse and that typologies should better reflect the identities of such territories the lack of data at a fine scale prevents such innovations departing from an updated conceptualisation of rurality based on the multidimensional nature of contemporary ruralurban interrelations and interdependencies granular will generate new insights for characterising rural diversity based on a multiactor and interdisciplinary approach based on insights from multiactor labs it will generate novel datasets using a wide range of methods and primary data such as remote sensing crowdsourced data mobile phone data and webscraping this data will then be combined with a variety of existing institutional data to derive indicators relevant to rural communities for the implementation of the longterm vision for rural areas ltvra so to measure resilience wellbeing quality of life and attractiveness this will enable granular to create a rural compass that take into account the factors affecting rural communities and their functional characteristics informing policymakers and rural actors for the design of tailored rural policies after ensuring the upscalability of the results datasets data visualization and other tools will be directly available on a dedicated platform designed by and for rural actors
co2 routes across europe

coreu will demonstrate key enabling technologies in a ccs value chain and support the development of three new ccs routes in centraleast europe cee helping accelerate ccs development coreu will a provide the means for development of an openaccess transnational network infrastructure and logistic to connect emitters with storage sites in europe by identifying multimodal transport requirements and developing emitters clusters to create the demand and the investment rationale b increase the knowledge of the ccs value chain across europe through interconnected initiatives sharing of experience knowledge and data to create a common framework that encompasses all key aspects of ccs deployment technological knowhow business models consensus management monitoring reporting and validation policy framework transport and storage safety coreu will contribute to 68mtyear in co2 reduction by 2035 and 36mtyear by 2050 develop 8 innovations for measurement monitoring verification interoperability and value chain monitoring and improve the internal rate of return of co2 infrastructure investment by 6 through derisking core technologies
hydrogenbased intrinsicflameinstabilitycontrolled clean and efficient combustion

chemical energy carriers will play an essential role for future energy systems where harvesting and utilization of renewable energy occur not necessarily at the same time or place hence longtime storage and longrange transport of energy are needed for this hydrogenbased energy carriers such as hydrogen and ammonia hold great promise their utilization by combustionbased energy conversion has many advantages eg versatile use for heat and power robust and flexible technologies and its suitability for a continuous energy transition however combustion of both hydrogen and ammonia is very challenging for technically relevant conditions both form intrinsic socalled thermodiffusive instabilities very different from the oftendiscussed thermoacoustic instabilities which can increase burn rates by a stunning factor of three to five without considering this computational design is impossible yet while linear theories exist little is understood for the more relevant nonlinear regime and beyond some data and observations virtually nothing is known about the interactions of intrinsic flame instabilities ifi with turbulence here rigorous analysis of new data for neat h2 and nh3h2blends from simulations and experiments will lead to a quantitative understanding of the relevant aspects from this a novel modeling framework with uncertainty estimates will be developed the key hypothesis then is that combustion processes of hydrogenbased fuels can be improved by targeted weakening or promotion of ifi and that this kind of instabilitycontrolled combustion can jointly improve efficiency emissions stability and fuel flexibility in different combustion devices such as sparkignition engines gas turbines and industrial burners guided by the developed knowledge and tools this intrinsicflameinstabilitycontrolled combustion concept will be demonstrated computationally and experimentally for two sample applications
resolving mechanisms of microbiome rescue to promote resilience to climate change

earths climate crisis threatens to disrupt ecosystem services and destabilize food security communities of microorganisms called microbiomes provide critical functions that feedback on climate and support soil and plant health i propose a new framework microbiome rescue to recover microbial populations and lost functions after disturbances with critical knowledge about the ecology of microbiomes and their contributions to creating resilient systems i propose that we can achieve a paradigm shift in ecosystem management via directed microbiome interventions here i focus on elaborating rescue strategies that leverage the selective reactivation of dormant microbes because microbial dormancy is extensive in soil and the rhizosphere reactivation offers access to untapped biodiversity and provides immediate solutions for maintaining functions in ecosystems affected by climate change my first objective is to understand and predict the capacity of dormant soil microorganisms to rescue microbiomes in a changing climate and discover reactivated bacteria that facilitate resilience my second objective is to investigate and develop bacterial reactivation for rescuebased microbiome management to support plant resilience to climate change stressors and preserve plantsoil feedback to achieve these goals i will execute three multifactor experiments to reactivate the dormant microbiome from soil and plant systems after exposure to heat and moisture stress first i will perform a heat and moisture experiment for european soils assess risk and curate microbial collections that support functional rescue next i will perform two practical rescue experiments for the microbiomes of legumes exposed to heat and moisture stress customized microbiological amendments and hostmicrobiome engineering this work will provide unprecedented insights into microbiome rescue and identify targets for biological interventions to support soil and crop resilience to climate change
developing trustworthy artificial intelligence aidriven tools to predict vascular disease risk and progression

the aim of vasculaid is to predict the risk of cardiovascular events and progression of the vascular diseases abdominal aortic aneurysm aaa and peripheral arterial disease pad to influence the course of disease improving the patients quality of life and care and assisting clinicians to make betterinformed decisions involving the patient vasculaid will allow us for the first time to identify patients who are at high risk for aaa growth or pad progression and cardiovascular events to this end we will deliver a clinically relevant and costeffective trustworthy aidriven platform vasculaid that integrates multisource parameters including imaging proteomic and genomic data as well as lifestyle patient data from wearables to enable personalised vascular disease management to maximise the personalised prevention strategies vasculaid leverages visualisation tools to improve clinicianpatient communication and empower the patient the vasculaid platform consists of ai riskprediction tools a patient communication app an a clinical dashboard to support clinical decisionmaking a particular emphasis is placed on ethics to ensure beneficial implementation of ai prediction toolsin this project we aim to 1 build an euwide data infrastructure 2 develop an aibased progression prediction tools for aaa and pad 3 develop criteria according to the comet initiative to assess the effectiveness of vasculaid and 4 clinically test and show proofofconcept for the vasculaid platform once validated this platform can be extended to other cardiovascular diseases cvds as well vasculaid brings together 14 leading organisations and 2 affiliated entities consisting of clinical academic centres institutes universities and smes as well as large industry patients organisations and policy makers that cover the full value chain to enable integration of the platform into clinical practice
extremophile cyanobacteria as life supporters for mars colonization

the curiosity and the interest of humanity in space exploration lead to important discoveries on fundamental questions about our place in the universe and push forward the development of new technologies new industries and important international relationships mars is the nearest planet to earth has evidence of water an element essential for life and a geological history similar to earth these characteristics turn it a source of inspiration and a possible home for humans in the future however it is an inhospitable place and several solutions are being pursued in order to help terraform the planet atmospheric composition cosmic radiation temperature and the lack of a protective magnetic field are just a few of the problems that humankind needs to face prior to considering mars colonization however there is a group of organisms that can be used to help solve some of the problems cyanobacteria why because they are simple oxygen producer organisms with low nutritional requirements and able to live in a wide range of extreme conditions and ecosystems moreover cyanobacteria can also be used as food sources to produce biofuels in bioremediation and as biofertilizers for instance and already proved to be good candidates for the task marcyan has the major goal of investigate the possible use of cyanobacteria to support mars exploration how using extremophile cyanobacteria isolated from a mars analog site rio tinto spain and submitted to marslike conditions in specialized planetary simulation chambers moreover marcyan intends to go beyond the conventional knowledge and will use transcriptomic and metabolomic analysis to uncover the possible mechanisms that can help to explain the survival of these organisms to extreme conditions opening the door to a more conscious choice of the best organisms to be used in space exploration
building a european strategic research and innovation area in direct synergy with eu and international initiatives for pandemic preparedness

the covid19 pandemic has confirmed and further highlighted the importance of planning and investing in research and innovation well before a health crisis occurs for this purpose the main goal of be ready is to build a consolidated european research and innovation area that provides the foundation of the candidate european partnership for pandemic preparedness so to improve the eus preparedness to predict and respond to emerging health threats by better coordinating funding for research and innovation at eu national and regional level towards common objectives and an agreed strategic research and innovation agenda the partnership is expected to build on existing pandemic preparedness networks and work in synergy with the health emergency response authority hera in close collaboration with ecdc ema and other relevant international and european actors be ready is composed by 24 organisations from 15 countries with complementary expertise and policy area ranging from public health organisations ministries of science university health innovation or environment and research performing organisations that ensures a crosscutting interdisciplinary global health and one health approach
unraveling brassinosteroid biosynthesis orchestrating br precursor movement via endoplasmic reticulumplasma membrane contact sites epcss

since their discovery in 1979 brassinosteroids brs have been extensively studied for their biosynthesis and signalling pathways now in the year 2023 one fundamental question remains how do brs move as the only type of steroidal phytohormones essential for plant growth and development brs act in a dosedependent manner and do not travel long distances therefore br homeostasis is key to their function recent findings in my host lab revealed that in the arabidopsis root the expression domains of br biosynthetic enzymes are separated and the completion of br biosynthesis requires celltocell movement of precursors thus revealing the importance of the shortdistance transport for br homeostasis maintenance further we revealed that plasmodesmata pd mediate the passage of brs between neighbouring cells however we still do not know where in the cell brs are synthesized and how these hydrophobic molecules are moving through pd by searching interactors of br biosynthetic enzymes my host lab found interesting candidates associated with the endoplasmic reticulum erplasma membrane pm contact sites epcss including pd epcss are known lipid synthesis platforms and contribute to pd function in plants here i hypothesize that brs are synthesized at epcss and epcss coordinate br biosynthesis and transport through pd in braction i will combine live cell imaging with stateoftheart imaging techniques to pinpoint br biosynthesis sites in the cell combining advanced proteomics genetics and biochemistry i aim to identify novel candidates that regulate br biosynthesis and movement linked to epcss finally i will employ genetics combined with bioorthogonal chemistry approach to assess candidate influence on br symplastic movement bractions interdisciplinary approach will address knowledge gaps in br homeostasis and drive major conceptual advances in understanding how br levels are maintained across different cell types and tissues