Dragon09/odtu_chatbot huggingface dataset:
towards ultrahigh dose rates in proton therapy an ionoacoustic approach for in vivo dose monitoring

the use of ultrahigh dose rates flash in radiation therapy has emerged as a promising modality to treat cancer due to its unprecedented ability to reduce healthy tissue toxicity while ensuring tumor control towards ultrahigh dose rates in proton therapy an ionoacoustic approach for in vivo dose monitoring rapid project aims at providing new insights into the clinical benefits of proton flash radiotherapy by resolving the challenge of realtime dose monitoring the action represents a powerful instrument to push the boundaries of cancer care with proton radiotherapy at three different levels i the optimization of an ionoacoustic imaging system for realtime pulsebased 3d dose monitoring ii the experimental evaluation of the physical requirements to achieve the flash effect by in vivo and in vitro studies under different beam conditions and iii the interpretation and optimization of the ionoacoustic signal response for different treatment plans the ionoacoustic imaging technique combined with an ultrasound system will enable to image simultaneously tissue morphology and dose deposition of the beam these technological advances will disentangle the complex and multiple variables influencing the yet unknown flash effect as well as enabling the first systematic study combining flash dosimetry and tissue damagetoxicity response the researcher will spend 24 months at the department of radiation oncology at massachusetts general hospital and harvard medical school boston usa and 12 months at the department of atomic molecular and nuclear physics at university of seville use spain and centro nacional de aceleradores national center of accelerators an use joint research center
flagship advanced solutions for condition and health monitoring in power electronics

there is a pressing need to ensure the seamless operation of reliable power converters prompting a concerted effort to explore new converter topologies innovative control techniques and advanced semiconductor materials like wide bandgap and ultrawide bandgap technologiesto address this challenge flagchip will pivot around three pillars of innovation 1 power modules including innovations at device and package level 2 condition and health monitoring of such power electronics and 3 cost efficiency of the proposed solution and the system as a whole these three pillars will group a total of 13 main innovations that will be developed and tested during the project in that sense some of these innovations include strategies for the prediction and prevention of equipment failures minimizing downtime and facilitating cost stress steering and maintenance routines also flagchip will enhance the efficiency of power electronics components facilitating the creation of a new generation of inverters converters and other power equipment for the energy sector additionally the project will reduce space occupancy with a primary focus on offshore applications while improving the cost efficiency of power devices and semiconductor fabrication processesflagchips approaches will be demonstrated within the projects partners research infrastructures including acdc and dcdc applications at two strategically chosen pilot sites in france dcdc mvdc converter and norway acdc offshore wind turbine and substation converter architecture to achieve that flagchip will rely on a competitive consortium formed by 10 partners from 7 different states with a strong research group and leading industrial companies on the sector 2 rtos 3 universities 3 large companies and 2 smes that will deliver 13 key exploitable results by the end of the project
human cardiac microtissues for studying lamin cardiomyopathy

lamin ac cardiomyopathy lmnacm is a rare genetic disorder caused by mutations in the nuclear lamin gene lmna affected patients typically exhibit dilated cardiomyopathy and reduced life expectancy due to sudden cardiac death or accelerated functional decay requiring the heart transplant intriguingly carriers of the same lmna mutation show a wide spectrum of genotypephenotype discrepancy however a clear mechanistical understanding remains elusive recently the host laboratory has developed an innovative multicellular threedimensional 3d human induced pluripotent stem cells hipsccardiac microtissue mt model where hipscderived cardiomyocytes display postnatal maturation allowing more faithful investigation of normal and pathological cardiac physiology i will leverage this model and combine it with my strong background in molecular and cellular cardiology to advance the understanding of lmnarelated pathologies specifically i will use patientderived hipsc from two family members with a severe and less severe form of lmnacm and their isogenic controls to generate 3d mt models next i plan to 1 characterize structural and functional properties and the transcriptome profile of multicellular lmna mt models and their controls 2 investigate cellcell cardiomyocytes endothelial cells cardiac fibroblasts and macrophages interactions relevant to the disease development and progression and 3 correct the identified molecular targets by pharmacological treatment or by crisprmediated gene editing the scientific industrial and economic community will profit from this project twofold first i will establish a costeffective model that provides better understanding of lmnacm pathogenesis avoids crossspecies variability and reduces the need for animal research and second i will test the implementation of potential treatment options with the ambition to achieve a step forward in developing personalized therapeutic approach for the end users
harnessing specialized metabolism from anaerobes

anaerobic bacteria a group of microorganisms that thrive in the absence of oxygen have a significant impact on the quality of life on earth they play a crucial role in biotechnology and are essential components of the gut microbiota as such they are of tremendous importance for human animal and environmental health on the other hand certain anaerobes can be lifethreatening pathogens in light of this there is an urgent need for a deeper understanding of the specialized metabolites of anaerobes which could function as chemical mediators virulence factors and antibiotics although genome analyses indicate that anaerobic bacteria hold an enormous potential for producing structurally unique compounds biosynthetic gene clusters are typically downregulated or silent under laboratory conditions synthetic biology approaches to unearth these cryptic pathways have been hampered by the lack of universal activation strategies the cumbersome genetic tractability of anaerobes and the incompatibility of standard expression systems with the oxygensensitive biosynthetic enzymesthe anoxygen project seeks to unearth the vast structural wealth of natural products from the anaerobic world and leverage their unique biosynthetic machinery using a highly versatile anaerobic expression platform this ambitious initiative comprises four work packages aimed at refining synthetic biology tools creating gainoffunction anaerobes discovering novel drug candidates and virulence factors and engineering biosynthetic pathways to create metabolic diversityby achieving these objectives anoxygen will grant a comprehensive overview on specialized metabolites and biocatalysts of anaerobes which have great translational value for medicine ecology and biotechnology in addition to providing valuable methods and tools to the scientific community this project has the potential to bring significant benefits for the health and wellbeing of people animals and the environment
firstinclass antipvr mab ntx1088 a novel oncology drug that unlocks the power of human immune system and revolutionizes cancer care

nectin therapeutics nectintx is a venturebacked company with a topnotch team focused on innovative therapeutic options for cancer patients to address the limitations of available therapies the company has developed a diverse pipeline of antibodies that overcome immune inhibitory pathways deployed by the tumours ntx1088 is a monoclonal antibody that binds human poliovirus receptor pvr and activates patients immune system to fight cancer through a triple mechanism of action never demonstrated before a comprehensive preclinical dataset was generated to show the robust antitumor activity of ntx1088 in vitro and in vivo following ind approval and strong backing from key opinion leaders phase i clinical trial has commenced aimed to enrol patients with solid tumours the project will accelerate the clinical development of ntx1088 towards a novel therapy on the 80 billion immuneoncology drug market resulting in better outcomes for patients and reduced societal and economic burden associated with cancer
industrial doctoral network on bridge digitalised integrity management

the bridgitise doctoral network will focus on the digitalisation of bridge management across the lifecycle through the development of innovative approaches to information management the basic idea underlying the project is that the achievement of excellence in this field requires the development and validation onsite of innovative technologies for the costeffective management of bridge information and their use to support decisions relevant to bridge integrity management across the lifecycle to this aim a network of 151 phd projects is structured around three main research and training clusters focused on the development and validation of innovative lowcost large scale and automatic technologies to collect bridge information artificial intelligence and iot technologies specifically tailored to bridges to process and share information digital decision support tools able to manage bridges across their lifecyclethe project will combine the expertise of six universities one research center and seventeen industrial companies and endusers who will provide case studies to apply and validate the project results thereby fostering the technological transfer of the research findings this powerful combination of expertise from industry and academia will introduce the dcs to the topics of the project and add to their intersectoral employability enabling europe to build worldclass competitive capacity in a strategic market deliverables of the bridgitise dn will be technologyenhanced training and dissemination tools international workshops and training schools furthermore an open platform for sharing data related to bridge management will be built to develop collaborative and informationsharing skills of the dcs and to increase the impact of the project
critical raw materials extraction in environmentally protected areas

ciran will develop test and validate processes to arrive at systemic policymaking balancing environmental protection and societal needs for accessing critical raw materials crms this will be achieved through 1 streamlined permitting procedures in environmentally protected areas 2 modern policies and social contract frameworks that reconcile the protection of environmentally sensitive areas and domestic sourcing of crms in the eu and 3 the development of a community of practice to support the uptake of the ciran recommendation and that will remain active after the project funding periodciran proposes a logical framework that justifies extraction on the basis of a systemoriented assessment and the cocreation of knowledge ie tested and validated by communities located in or nearby environmentally protected areas it will create novel social contract models identifying rights obligations and responsibilities of governments nationalregional communities and mine operators capable of dealing with transformations and challenges due to climate changeas a distinctive feature ciran brings together 25 external experts on the environmental political social economic and technological factors that will shape the energy transition responses and the demand for crms these experts organised in four expert groups egs will work with the consortium conveying insights on policymaking and implementation economic drivers technologies mining local governance social capital nature conservation and biodiversity the egs will actively engage in ciran through synergetic processes combining analysis and deliberation and participation in project workshops and structured consultations eg focus groups foresight analysisthe consortium is geared to develop inclusive policymaking instruments that support the eu green deal and unled reforms to reach the climate commitments and sustainable development goals
the ethics of loneliness and sociability

loneliness which can be defined as the negative mental states eg sadness despair that people experience when they feel that they do not have enough relationships or not the right kinds of relationships is a widespread phenomenon in many societies even prior to the current pandemic surveys from europe and northamerica reported that 20 to 35 percent of adults between the ages of 65 and 79 say that they are frequently lonely a figure that rises to 40 to 50 percent among those aged 80 and above other groups that are at high risk of chronic loneliness include informal caregivers people with disabilities and adolescents with 40 percent of 1624 year old britons saying that they are often or very often lonely these statistics are worrisome as chronic loneliness has been found to contribute to eg depression dementia and poor physical health with some medical experts arguing that its health effects can be compared to those of smoking 15 cigarettes a day in addition to this loneliness takes a heavy economic toll in the uk for instance it is estimated that ill health associated with loneliness costs employers 25 billion gbp every year yet while the severity of these harms and economic costs makes loneliness prevention and alleviation a highly important topic to study as psychologists and sociologists have long realized philosophers have paid scant attention to it the aim of this project is to fill this lacuna through ethical analysis and reflection on relevant philosophical psychological and sociological literatures it will investigate what moral duties private individuals and societies more broadly ie states have to help protect people from loneliness and to help ensure that people can protect themselves from loneliness this will culminate in the development of the first normative theory of loneliness within the scholarly literature and in the establishment of a new subfield within moral and political philosophy
controlling autophagy in the intestine to rejuvenate

human life expectancy is continuously increasing worldwide however longer lives must be accompanied by the increased health of older people therefore the scientific community has set a goal to understand the causes of aging and how to revert them aiming not only at living longer but living healthier with this proposal using telomerase mutant zebrafish as a prematurely aging model i aim to determine the interdependency between autophagy and aging in particular i will determine if modulation of autophagy can revert the causes of aging and improve organisms health span knowing that the intestine is one of the first organs that deteriorate during adulthood i will alter autophagy specifically in the intestine to revert inflammatory and behavioral phenotypes of aged fish moreover i will study specific dietmicrobiome associations in the intestine that might affect intestinal integrity autophagy and organism aging the outcome of this research will create highquality new knowledge on the relationship between gut autophagy and individual aging and will provide guidelines for the development of new antiaging approaches
multidimensional interferometric photoelectron spectroscopy with extreme ultraviolet photons

photochemical reactions are the central driving force in nature and in sustainable technologies understanding photochemical reactions on the quantum level is thus a primary goal in science however this task remains a major experimental and theoretical challenge even on the singlemolecule level due to the involved ultrafast time scales predominantly nonradiative processes and strongly coupled degrees of freedom methods are needed that provide a gapless view on the molecular mechanisms with the necessary sensitivity and selectivity to uncover and disentangle the participating reaction pathways in this project we will for the first time establish ultrafast multidimensional extreme ultraviolet xuv photoelectron spectroscopy to solve this problem this method is capable of mapping photochemical processes with unprecedented spectrotemporal resolution along the entire reaction coordinate while unraveling otherwise degenerate pathways in multidimensional correlation maps this becomes possible with the unique combination of concepts from coherent multidimensional spectroscopy with femto to attosecond xuv light sources and photoelectron spectroscopy as spectroscopic probes wellcontrolled model systems will be investigated ranging from isolated cold molecules and molecular complexes to individual species embedded in tailored nanocluster environments the proposed project will a establish laboratorybased highresolution xuv photoelectron spectroscopy as a widely accessible alternative to experiments at synchrotron and freeelectronlaser facilities b introduce the concept of coherent multidimensional photoelectron spectroscopy c develop new theoretical analysis methods of transient multidimensional photoelectron data d resolve the details of fundamental intra and intermolecular photochemical processes including elusive nonadiabatic and quantum coherence mechanisms e elucidate the role of tailored environments in molecular dynamics
deep eutectic solvents for membrane transport of nucleic acids

the delivery of nucleic acids as therapeutic methods holds great potential to provide new treatments against emergent pathogens and important diseases however the development of functional therapies is often hindered by the poor efficiency and stability of the current transport technologies deep eutectic solvents des are nonaqueous sustainable liquids obtained through the combination of simple organic molecules the physicochemical properties of the des can be tailored through the selection of their constituents to optimally perform in specific applications des have been recently shown to increase the stability and activity of nucleic acids na as compared to those in aqueous systems despite the excellent and encouraging physicochemical properties of des these solvents have not been investigated to date for the transport of na across cell membranes this project will finally fill the knowledge gap that exists between the promising properties of des and their potential ability to selectively deliver na into the cell cytosol here a combinatorial approach will be used to synthesise a library of des with different properties relevant for transport eg amphiphilicity and charge density the ability of these to enable membrane transport of na will be investigated as a function of the system properties the exclusive properties of the des solvent will go beyond the stateoftheart as they will allow i finetuning of descargo interactions and binding strength by des counterion adjustment ii precise hydrophobic des control for membrane partition regulation iii enhanced physicochemical stability of the resulting particles and simpler synthetic and scaling up methodology as well as reduced production costs overall this project is aimed to discover a completely new range of potential applications of des in membrane transport and biomolecular cargo preservation which will open a new research field of potential applications in na delivery
development of next generation pathways leading to just energy transition and industrial deep decarbonization

foundation industries cement steel glass ammonia etc are classified as hardtoabate sectors due to the inherent hightemperature processes decarbonization of industry is technically possible through a combination of technical solutions the optimum mix of which will vary widely between sectors and regions deep decarbonization technologies such as application of alternative carbon neutral fuels and carbon capture are essential to achieve the target of net zero by 2050 in the euthe project aims to evaluate develop and demonstrate the advanced and emerging technologies for sustainable energy transition and industrial deep decarbonization firstly the project attempts to remove the barrier associated with high operational and infrastructure costs incurred by the traditional carbon capture and storage ccs technology applying aqueous scrubbing the project also evaluates and justifies the potential of a negative co2 emission solution by combining ccus with biomass derived carbon neutral fuels beccs in addition the project aims to conduct a comprehensive feasibility study on the application of ammonia in selected industrial processes as an alternative carbon neutral fuel to replace fossil fuels the project attempts to apply a wide range of research methods at different scales from microscopic material design to laboratory scale testing and pilot scale trials and finally to industrial scale deployments supported by the industrial partners multiscale modellings such as reaction kinetics modelling cfd modelling and process modelling will be performed for system optimization technoeconomic analysis and life cycle assessment on carbon footprint of the full supply chain will be conducted for all three abovementioned decarbonization pathways additionally artificial intelligence ai driven approach will be used to predict the dynamic co2 emissions from industrial sites under scenarios using different combinations of renewable fuels with ccus
development of bismuth chalcogenide sustainable thin film pv technology

the eu set an ambitious goal towards decarbonising the energy system and to reach climate objectives in 20302050 pv is recognized as one of the key renewable energy solution to fulfil the climateneutrality defined by strategical setplan target of 30 10tw worlds energy demand by 2050 to meet these goals in an economically and environmentally meaningful way energy demand and co2 emissions for the production of pv cells must be well below those of mainstream crystalline silicon todays available highly efficient thin film tf pv technologies relies on scarce elements indium in cigs tellurium in cdte or contains elements like lead or cadmium that fall under the eu rohsdirective boostpv proposes development of novel absorbers and proof of concept tf solar cells entirely based on emerging lowcost earth abundant and green bismuth chalcogenide pv materials the approach is based on a rapid technological development of low temperature processes using robust resource saving high yield and easily scalable close spaced sublimation technique boostpv will promote the research excellence of the fellow and research group via twoway transfer of knowledge strengthening their expertise and innovation at international level costefficient stable and lightweight tf solar cells will be fabricated using processes with reduced environmental impact and carbon footprint paving a solid base for further development and deployment of groundbreaking technologies that will feed the innovation cycle progress in bipvpipv application variability and support the value chain of the next generation pv in eu