Dragon09/odtu_chatbot huggingface dataset:
mechanistic systems modelling of plant environmental adaptation and cam photosynthesis engineering

a major goal of evolutionary biology is to reconstruct evolutionary trajectories and outcomes from mechanistic descriptions of the interactions between organisms and their environment this goal is rarely reached due to the complexity of these interactions and their effects on fitness recent advances in computer technology that facilitate the solution and optimization of large mathematical systems have now brought such models into reach in mechsys i propose to develop a computational framework that builds on biochemical and physical principles to reconstruct how the interaction of the environment with plant anatomy water transport photosynthesis and metabolism shapes plant physiology and fitness mathematically the model comprises thermal balances as well as the balances of metabolites and water in different plant organs and in the compartments of leaf cells using net co2 fixation per root area over multiple days as a proxy for fitness for a given climate and soil the model will estimate fitness based on anatomical parameters and on systemslevel protein concentrations and enzyme regulation these estimates will allow us to rationalize the evolution andor predominance of different types of plants in specific habitats we will validate the model against proteomics and metabolomics data from representatives of c3 plants and the much more water use efficient cam plants covering desert plants as well as epiphytes moreover we will simulate evolutionary trajectories towards cam photosynthesis and succulence two traits whose evolution appears to be interlinked finally we will utilize the model to propose optimal strategies for engineering crops to become more droughtresistant in increasingly hotter and drier climates overall mechsys will establish test and apply a groundbreaking mechanistic systems modelling framework for evolutionary plant biology which will allow deep insights into the selective forces that shape plant physiology and evolution
skill bill skill to boost innovation and professional fulfillment in a sustainable economy

skillbills overall objective is to develop a large and strong foundation for the growth and acceleration of renewable energys deployment thanks to engaging with stakeholders of the whole chain diffusing scientific culture and skilling multilevel workersthe basic idea underling the project is that the knowledge should be diffused at several different levels and qualitatively appropriate both to train the adequate number of workers and to increase res awareness and to reach a more social and inclusive europethe project aims at creating several pathways to induce target groups to get interested or involved in res besides their initial level of education and their working position the technological res potential can be reached by increasing hard and soft skills of potential users and stakeholders developing interest in the topic and having clear and appropriate approaches such as tools and learning modules using suitable language its important beside the creation of instruments for the upskilling and reskilling of workers technician and designers to have awareness modules for unspecific public in order to fight against ignorance fake news gender gap and the phenomenon of functional illiteracy it is widely documented that lifelong suitable learning process is the fundamental driver to support the development maintenance and update of skills skillbill proposes concrete actions to accelerate the deployment of renewable energy at different levels1stakeholder community engagement 2knowledge sharing and peer learning3skilling upskilling reskillingskillbill will i analyse and involve all the interested parts in open discussion using adequate language ii create several different pathways to increase skills after having mapped knowledge gap and without gender prejudice iii develop and implement innovative learning method vi evaluate the work performed
panideologies in central europe paradoxes of rightwing selforientalism

the rise of rightwing populism in central europe coincides with the revival of panideologies cases of turanism promoted by the ruling party in hungary and panslavism popular among rightwing activists in slovakia pose a need to study these intellectual projects simultaneously in comparative and historical perspectives the common feature of these competing traditions is a contradictory combination of racism and selforientalism adepts of turanism and panslavism often define themselves as belonging to a noneuropean race and simultaneously sympathize with typical farright consensus on white supremacy why are panideologies rooted in outdated pseudoscientific theories so popular among rightwing populists of central europe today to answer this question we need to conduct a multidisciplinary study combining social anthropology and history the proposed project aims to understand how modern adaptations of panideologies differ from the original versions popular in the first half of the 20th century and how these transformations correlate with the aims and resources such as access to state institutions of the ideologues the novelty of the research project includes the suggestion to look at rightwing ideologies as phenomena embedded in the colonial and postcolonial history of the region i propose to study turanism and panslavism as products of contact zones coevolving and constantly influencing each other and affected by overlapping colonial regimes and postcolonial conditions following the guidelines of the horizon europe programme to support social cohesion and inclusiveness we need to conduct a focussed study of processes of polarization the research project aims to explain how panideologies attract new followers and why they are becoming popular again since the beginning of the last century
boosting upstream and downstream processes to maximize yield of phb production and 23butanediol

a circular biobased economy is a key element of a european low carbon economy and is projected to increasingly contribute to greenhouse gas ghg emissions reductions decreased dependence on fossil resources and drive economic growth over the next decades it can help meet the european green deals goals including its plan to reduce eu greenhouse gas emissions by at least 55 by 2030 compared to 1990 levels it also contributes to other eu initiatives including the circular economy action plan the biodiversity strategy zero pollution action plan and the farm to fork strategy eu biorefineries producing biobased products are expected to be an important part of the circular biobased economy moreover deployment of biorefineries that utilise eu biomass will increase safe supply of raw materials decrease emissions and create jobs and business opportunities especially in rural areas approximately 300 chemical and material driven biorefineries at commercial or demonstration scale are located in the eu promofer project will address the valorisation of two kinds of feedstock lignocellulosic biomass and food industry waste through the improvement of the fermentation processes and downstream purification it will be produced 3 ssbd circular biobased products 1 2 polyhydroxyalkanoates phas to be used in geotextile nets applications agriculture sector and coated paper packaging applications packaging sectors 3 23butanediol 23bdo to produce biobased pu for the technical textile applications in the fashion industry sector the integration of these waste streams as biorefinery feedstocks will allow reducing the volumes of landfilled waste improving competitiveness resource efficiency and opening new opportunities for the bioplastics production with added advantages of environmental performances and social acceptance
public trust in contemporary europe trusting the antitrust protrust

large firms such as amazon google and facebook have been making worldwide headlines for abusing their market power and violating antitrust rules within the european union eu the european commission ec has been a regulatory powerhouse in competition policy with the capacity to counterbalance unfair dominance of large firms such antitrust cases tend to gain news coverage and lead to discussions in the public sphere in other words they become subject to politicisation but does politicisation affect citizens trust in public authorities and large companies and if so how protrust public trust in contemporary europe trusting the antitrust investigates the effect of politicisation of eu antitrust cases on citizens trust in the european commission and in the firms involved it does so through an innovative combination of 1 a claimsmaking analysis of media coverage of antitrust cases in selected countries and 2 survey experiments based on the identified media frames from the claimsmaking analysis protrust is hosted by arena centre for european studies university of oslo where it benefits from the expertise of prof tobias bach and other academics in the areas of trust public administration and eu studies it also relies on the support of two secondment institutions govtrust centre of excellence university of antwerp and lund university adding key expertise in the areas of political economy transparency and technology protrust builds a bridge between politicisation and trust research advances knowledge on politicisation in the field of competition policy and provides a novel analysis of the impact of media frames in relation to competition and antitrust considering the dominance of large firms and the emerging challenges of democratic governance in the digital age analysing the link between politicisation and citizens trust is a timely and pressing topic
therapeutic discovery for cholangiocellular carcinoma

cholangiocarcinoma cca is one of the deadliest cancers comprising a heterogeneous cluster of malignancies that are distinct to hepatocellular carcinoma hcc and that can emerge at any point in the biliary tree while not very common cca is responsible for 2 of cancerrelated deaths worldwide annually and rising the incidence in european countries is increasing rapidly ranging from 1 to more than 4 cases100000 cca is mostly diagnosed very late resulting in aggressive disease progression poor treatment response and dismal prognosis with a median survival of less than 2 years curative hepatic resection is an option in 1030 cases and is mostly linked to recurrence within 12 months in over 50 of patients for most patients diagnosis will occur when the disease is already too advanced and the only options are chemotherapies or palliative care current standardofcare for cca is unsatisfactory with very limited efficacy and adverse effects recently approved secondline therapeutics slightly improve outcome but are only suited to a small subset of cca patients thus there is a major unmet medical need for novel therapeutic strategies to improve patient outcome based on a robust data package obtained in a panel of cca models within erc hepcir here we will explore the use of a novel class of compounds exploiting a unique and differentiated firstinclass mechanismofaction and validate their efficacy in vivo as a firstline therapeutic for cca proofofconcept studies will be performed in stateoftheart patientderived models combined with scrnaseq and proteomics the data obtained will serve as a preind data package for this indication an established collaboration with a pharma partner will ensure fasttrack completion of the preclinical development towards ind collectively erc poc candy will deliver completed proofofconcept for a novel therapeutic approach for cca which has the potential to transform patient care
tff2 production and molecular mechanism studies to support new therapeutic approaches for gut diseases

inflammatory bowel diseases ibd are chronic gastrointestinal gi conditions which affect approximately 13 and 2 million people in europe and north america respectively with a growing number of incidences in asia as well currently existing therapies only alleviate the symptoms and suppress the inflammation but dont promote gut repair the development of novel therapies is limited by a lack of understanding of the underlying processes of gut healing and repair although trefoil family factors tff are major players in gut epithelium restitution and repair very little is known about their molecular mechanisms and interaction partners in this project i will attempt to close this knowledge gap and will focus on trefoil family factor 2 tff2 the proposed project aims to identify tff2 interaction partners i study their structureactivity relationships ii and produce tff2based peptidomimetics iii i will use chemical synthesis coupled with structure elucidation to design and produce tff2 photoactivatable probes for the identification of tff2 interaction partners then structureactivity relationship studies of tff2 and identified partners will be carried out to define structural determinants of binding and activity based on this knowledge i will design novel tff2based peptidomimetics and study their stability binding to tff2 targets and effect on epithelial restitution the proposed project will deliver fundamental insights into molecular mechanisms of gut healing and yield a set of novel peptidomimetics which could serve as leads for further development of therapies for ibd and gi conditions
ultrafast holographic ftir microscopy

many human pathologies such as cancer are due to complex biochemical alterations that start at a subcellular level and lead to progressive changes that result in a heterogeneous tumor composition the polyclonality of tumor cells hampers the diagnosis and the therapy giving rise to tumor clones that lead to therapy resistance and promote metastases an accurate diagnosis of tumor biopsies to identify these particular cell clones is crucial to provide targeted therapy tailored to the tumor characteristics to improve the patient outcomes and increase survival rates for this vision to come true we introduce ultrafast holographic ftir microscopy trophy as a paradigm shift in vibrational microscopy blending elements of photothermal infrared ptir fourier transform ftir and digital holography microscopy dhm trophy brings these techniques to the unprecedented ultrafast timescale where the refractive index change induced by coherent ir vibrations is probed at its peak value before thermal relaxation trophy borrows from ptir the combination of ir vibrational excitation with visible probing for high spatial resolution from ftir the use of timedomain interferometry to obtain a high spectral resolution from broadband excitation from dhm highly sensitive and quantitative detection of the refractive index phase change combined with artificial intelligence algorithms this technology will enable quantitative concentration imaging of molecular biomarkers with high spatial resolution high chemical selectivity and high speed with a transformative impact on medical research and clinics in oncology it will be applied to intraoperative diagnosis of tumor biopsies providing tumor grading staging and subtyping and supporting complete tumor resection it will also allow to determine the best therapeutic approach tailored to the patient and identify resistant tumor clones under targeted therapy paving the way for precision medicine in cancer
molecular mimicry and immune evasion in malaria parasites

parasites have evolved elaborate strategies that maximise their fitness central to these strategies is their interaction with the host immune system for instance with immune receptors which mediate pathogen recognition or immune tolerance human malaria parasites encode a family of 200 rifins some of which are molecular mimics of human selfidentifying proteins and that bind toleranceinducing receptors however very few host targets of rifin proteins are known our data suggests that the family at large may form an elaborate repertoire of immunomodulatory effectors we postulate that rifins are deployed to manipulate host immunity in order to facilitate parasite persistence in its host we further hypothesise that this immune regulation is underpinned by a complex specificity code and a distinct bethedging expression program in the trojan project we will investigate and contextualise immunomodulation by malaria parasites in the arms race between the parasite and its host firstly given the sequence diversity of rifins we will optimise a method to measure gene expression without the need for a reference genome on a single cell level we will then deploy this tool to understand how expression of rifins is associated with malaria symptoms and persistence in longterm natural infections secondly we will decipher the range of immune targets of rifins as well as the rifinspecificity code and use lineage tracing to understand how diverse immunomodulatory expression patterns arise finally we will seek to understand how malariainfected individuals respond to immunomodulation by interfering with rifinreceptor interactions altogether we will reveal how pathogen molecular mimicry and manipulation is central to their success this study will transform our understanding of fundamental aspects of parasite biology as well as immune homeostasis and could provide new tools in the continuing fight against malaria
demystifying mechanisms of metal impurities during co2 mineralization of industrial solid wastes

anthropogenic climate warming has led to more frequent climate extremes and pollution episodes posing serious threats to the ecological environment and human health the rapid development of co2 mineralization technology for industrial solid wastes offers a promising solution to encapsulate co2 while stabilizing wastes however unlike desirable natural silicate minerals like olivine and wollastonite industrial solid wastes exhibit a complex and diverse composition the efficiency of mineralization in the carbonation process can be significantly impacted by the competitiveness of impurities relative to camg whereas the correlated systematic assessments of impurities competitiveness remain lacking in addition the leachability of potentially toxic elements after mineralization has not been explored raising significant safety concerns encapsulate takes an interdisciplinary approach combining the researchers experience in waste characterization and thermodynamic modeling with the supervisors expertise in interfacial geochemistry and molecular modeling to address these hitherto neglected challenges headon to this end encapsulate will establish publicly available datasets and novel models to i estimate the impurities constraints on mineralization efficiency at the outset ii propose possible strategies to reduce the environmental impacts of using carbonized products in practical applications and iii link co2 emission to specific activities in industries the outcomes will benefit eu organizations and industrial stakeholders engaged in co2 mitigation efforts the fellowship will be carried out at universit grenoble alpes isterre joint research unit and work with both academics psi esrf cnrs and empa and industry partners amiii the supervisors expertise and the organizations equipment ensure successful research progress and unsurpassed academicindustry intercommunication
the diplomacy of small states in early modern southeastern europe

this project aims at producing a synoptic analysis of the foreign policy of small states in early modern southeastern europe for centuries the rulers of the crimea moldavia and wallachia ragusa transylvania and cossack ukraine had to cope with their difficult geopolitical situation of being at the borderlands between christian europe and the ottoman empire the project will be the first attempt for writing a comparative history on the following questions 1 what kind of strategies these small states followed in order to overcome their vulnerability and survive on the frontier not only of empires but also of civilisations 2 what was the impact of being placed at cultural borderlands upon their diplomatic practices 3 how did they try to overcome the problem of having to communicate and present themselves in two radically different political languages ie of their powerful muslim and christian neighbours 4 how did the agents of diplomacy function in this peculiar geopolitical and cultural context how did it shape their status practices and the kind of social gains available to them
c and nterminal epitope conjugate immune cell targeted vaccines

cnectvax will validate the technical and commercial feasibility of a new cancer vaccine platform that uses nanobodies targeting dendritic cells to codeliver antigens in vivo as of 2019 cancer affects over 19 million people worldwide and results in almost 10 million death annually however the treatment of patients remains a challenge immunotherapy options including dendritic cell dc based vaccines have become available but the clinical efficacy of such treatment remains very modest and restricted to patient subsets to overcome the limitations in the current stateofart solutions and break barriers to achieve higher clinical efficacy dr martijn verdoes proposes a novel molecular vaccine strategy that effectively delivers target antigens to dcs in vivo in the patient to concomitantly induce robust synergistic cd4 and cd8 t cell responses the technical feasibility of cnectvax will be assessed both in vitro and in vivo using monocytederived human dendritic cells modc and a mouse model containing humanized dcs respectively in both systems the functionality of dcs and the consequent t cell activation and immune responses will be measured subsequently commercial feasibility will be determined by verifying ip position and strategy performing indepth market and competitor analyses and finally consolidating these into a business plan to establish the best path to commercialization successful commercialization of cnectvax could reduce the profound socioeconomic burden of cancer extend and improve the lives of patients provide the pharmaceutical industry with further collaborative opportunities and stimulate further scientific research based on this platform to treat other pathogenic diseases
inflatable concept aeroshell for the recovery of a reusable launcher stage a flight demonstration initiative

the icarus initiative targets to fulfil the following calls objectives1 contribution to the maturation up to trl56 of enabling new technologies and subsystems including common building blocks inthe field of reentry solutions for space transportation2 maturation up to subsystem and system level technology demonstration with respect to the technologies for recovery of spacetransport vehicles elements launcher stagesin that regard the project will address the innovative reentry solution based on inflatable heat shields ihs deemed applicable forrecovery of launch vehicles stagesin order to demonstrate applicability of this innovative solution for the purpose above the project will pursue the following endgoalsa complete the maturation on ground of the key technologies enabling the inflatable heat shields flexible tps and inflatablestructureb carry out a missionsystem design loop to realize and fly in relevant environment a meaningfulscale demonstrator of aninflatable heat shield through a flight on board a sounding rocket where the upper part of the rocket will be recovered thanks to theihs demonstratorc execute postflight analysis and rebuilding for technology performance evaluation system behaviour identification and modelsverificationcrosscorrelationthe project will lean not only on the achievements and knowhow obtained in the frame of the father projects efestoefesto2respectively funded by h2020 and horizon europe firstbatch but also on the partners heritage in the reentry and flightdemonstration field consolidated through pastrecent projectsthe current programmatic picture of the initiative is to lean on a full eu consortium to complete the project in a 4year plan to carry out 1 flight campaign in eu with exploitation of eu assets test range sounding rockets ground segment