Dragon09/odtu_chatbot huggingface dataset:
unveiling the molecular secrets of reproductive mood disorders a multiomics approach project

reproductive mood disorders rmds including premenstrual disorder and postpartum depression have a significant impact on women and their families contributing to the wellknown gender gap in mental health however effectively diagnosing and treating rmds remains an ongoing challenge these conditions are closely tied to hormonal changes during menstruation and childbirth indicating a shared vulnerability while the precise mechanisms are not yet fully understood emerging data including my work supports the hypothesis that genetic predisposition chronic inflammation and metabolic dysfunction play pivotal roles in the development of rmds the moodmap project aims to discover novel molecular markers for rmds provide insights into the biological factors influencing varying vulnerabilities to mood disorders in women and enhance diagnostic preventative and treatment strategies for rmds the endeavor leverages three nordic populationbased cohorts a to depict a comprehensive architecture of rmds by integrating genomic inflammatory proteomic and metabolomic data b to triangulate evidence for identifying biologically functional and causal biomarkers using cell data manipulated with hormones and advanced epidemiologic methods c and to predict treatment outcomes including treatment resistance and subsequent suicidal behavior through multiomics data and machinelearning methods moodmap adopts an innovative approach by studying both rmds together aiming to uncover the biological basis of female vulnerability to mood disorders through multiomics data by integrating advanced omics techniques hormonemanipulated cell data and cuttingedge epidemiologic and statistical methods moodmap holds the potential to understand the psychiatric sensitivity associated with sex hormones drive transformative changes of diagnosis prevention and treatment strategies for rmds and ultimately contribute to the reduction of the gender gap in mental health
euafrica concerted action on sarcov2 virus variant and immunological surveillance

despite of the successful advances achieved to date in the fight against the covid19 pandemic with the development of vaccines and therapy the worldwide propagation of sarscov2 has resulted in the rapid evolution of this virus and in the emergence of variants of concern voc that may dampen the efficacy of the first generation vaccines to tackle the challenges associated with the voc the covicis program is proposing a global approach with a powerful stateoftheart virologic and immunologic platforms coupled with large genomic surveillance studies and diverse cohorts in eu and ssa this allows covicis to contribute to the early identification of emerging voc and address key unanswered questions regarding i the susceptibility to infection with voc after a prior infection in the setting of a longcovid or after vaccination with different vaccines ii the risk posed by voc in immunocompromised patients and iii the modalities of infection and immune responses in children the diversity of the cohorts provides a unique opportunity to study virus evolution in different settings where sarscov2specific humoral and cellular immune responses are predicted to vary very significantly beyond the genomic surveillance the groundbreaking research and innovation of the program is the characterization of virologic and immunologic properties of voc and the identification of immune correlates of protection after disease or vaccination covicis ambitious goals are only achievable thanks to the existing population studies and cohorts funded by national and international public agencies and publicprivate partnerships and the combined collective expertise of covicis partners in the fields of epidemiology genomics virology immunology data science and public health
development and trafficking of type 1 and type 17 mucosalassociated invariant t cells

mucosalassociated invariant t mait cells colonize mucosal tissues where they become tissueresident and have important protective and homeostatic functions mait cells are selected in the thymus by microbial metabolites presented by mhcrelated protein 1 mr1 on thymocytes thereby acquiring an effector phenotype type 1 or 17 this project aims at elucidating mechanisms that regulate the last stages of thymic mait cell development including their egress and identify cues necessary for tissue colonization specifically we will couple transcriptomics and thymus transplantation models to analyze canonical thymic mait cell development thereby identifying new regulators of the mait117 fates as well as to identify mait cells that recently exited the thymus and seeded mucosal organs thereby identifying new regulators of tissue adaptation these targets will be functionally tested in models combining crisprcas9 encoded by lentivirus with bonemarrow chimeras or adoptive transfers additionally we will determine the identity and dynamics of mait cells exiting the thymus to colonize tissues by combining different experimental approaches including in vivo edubiotin labeling thymectomy and blockage of thymus egress lastly we will address whether mr1microbial metabolites are required for the maintenance of mait cells in tissues at steadystate using monocolonizationdecolonization of germfree mice and by conditionally ablating mr1 overall this work will uncover fundamental mechanisms underlying mait cell development and tissue colonization albeit outside the scope of this work it is possible that the mechanisms uncovered here may have implications in other innatelike t cells or for the establishment of mainstream tissueresident t cells
greening european mobility through cascading innovation initiatives

geminis vision is to accelerate the progress towards climate neutrality by reinforcing a modal shift through the demonstration and uptake of new shared mobility services active transport modes and micromobility and their integration with public transport in new generation maas services gemini will contribute to inclusive safe resilient transport and smart mobility services for passengers and goods in 4 areas ideveloping and testing sustainable business models for new mobility services nms including shared connected automated vehicles and shared mobility public transport and publicprivate partnerships to increase shared mobility maas and maac solutions for enterprises families and touristsiicreating digital enablers to accommodate mobility services collaboration platforms and multimodal maas solutionsiiiactively engaging stakeholders cocreation and integrating in nms social innovation practices towards incentivising behavioural shift and user acceptanceivcreating policy recommendations to enable scaleup and replicability of the delivered results in the elaboration and implementation of sumps urban mobility planning frameworks and contribute to the civitas impact assessment frameworkgemini will define ideate cocreate validate amplify and upscale five dimensions of innovation business social behavioural operational technology enablers and governance policy framework for delivering safe resilient accessible affordable and sustainable shared mobility solutions and demonstrate them in 4 mobility living labs amsterdam copenhagen munich turin and 4 twinning cities helsinki paris porto ljubljana the mlls will stimulate improved access to public transport whilst introducing sustainable mobility business models in urban and periurban contexts in turn leading changes in mobility patterns and behaviours aimed at less carcentred urban mobility systems
initial conditions for quark and gluon matter formation at the lhc

the central goal of heavyion physics at the energy frontier is to create and study in the laboratory quarkgluon plasma qgp a state of matter predicted by the fundamental theory of strong interactions current stateoftheart interpretation of experimental data from the lhc experiments relies on bayesian global fits of anisotropic flow vn and mean transverse momentum pt and provided the first quantitative measures of the fundamental transport parameters shear and bulk viscosity of the qgp this represents the best understanding of the qgp so far however recent studies of the correlations between anisotropic flow and mean transverse momentum reveal that no existing bayesian analysis can describe the new data in a consistent way because of the lack of constraints on the initial conditions which set the stage for the subsequent dynamic evolution hence it is scientifically urgent to significantly improve understanding about the initial conditions in the various collision types that can be probed at the worlds leading facility the large hadron collider to be able to extract precise properties of the qgp and its dynamic evolution as a function of temperature time in this erc project i will develop methodology for studying genuine correlations between vn and pt using a new approach a multiparticle cumulants technique this will give unique insights into the initial geometric conditions shape size and their correlations and fluctuations to achieve this i will measure on various collision systems 129xe 16o and proton during the coming lhc run 3 these pioneering measurements and the resulting new analyses will decisively advance our understanding of those crucial initial conditions that are the platform upon which the analysis of the entire collision rests the results of this erc will make it possible to determine the ultraprecise qgp properties and discover the new physics that could revise our concepts of the initial conditions
epistemology in science technology engineering arts and maths

the main aim of epistemology in art science technology episteam is to develop a collaborative consortium and intersectoral network to test the hypothesis that diversification of epistemological positions could be the key to responsible epistemology in technological education and innovation the fundamental problem being addressed is the impact of digital technologies on the construction of knowledge and truth an epistemic crisis inside and outside academia epistemology is explored as cultural episteme disciplinary epistemology and whole experimental approach epistemological diversification through transdisciplinary research is essential and will be investigated through the intersections of art science and technology by an expansion of the concepts techne technics and technology in the context of disciplinary activity in the contemporary context of globalised computational conditions the question of the impact of digital technologies on knowledge is often understood as misinformation and posttruth however there is also an inbuilt epistemological conditioning taking place through the digital technologies themselves for this purpose a large transdisciplinary research mobility is necessary in order to understand the localised contextualisation of digital technologies within the disciplines cultures and research laboratories the traditional epistemological frameworks and paradigms are currently challenged by globalised computational models where reason itself has been reduced to calculation and probability episteam will explore and challenge this dominant epistemological claim just as a biodiversity is necessary for the future sustainability of the planet so too is a technodiversity within the technosphere of globalised computation the partners are from the european university of technology ect lab usa india and nonacademic partners in europe sme and public bodies
morphing computerized mats with embodied sensing and artificial intelligence

the mozart project aims to advance the stateofthe art in robotic handling and manipulation of soft and heterogenous objects the approach we take is a radical departure from existing manipulator approaches as we will develop a new concept for manipulation through the use of deformable manipulation surfaces supported by aipowered control and learning tools the manipulation surface is able to change its curvature locally and through this manipulates objects on the surface the manipulation surface has three constituent elements a conventional modular electronics layer responsible for communication power and computation an actuation layer based on origami mechanisms and finally a soft poroelastic sensing skin the hardware development is complemented by a distributed control application programming interface which is built on cellular automata and deep learning the framework includes basic and coordination primitives that allow for manipulation of individual objects and groups of objects respectively for demonstration we have chosen three target demonstrators in the food handling industry which are descaling fish sorting of chicken and presentation of chicken the final pillar of the project is an integrativeinterdisciplinary social sciences and humanities approach that tackles the transition of the role of the operators today to more highskilled jobs in the future it also addresses the general ethical challenges surrounding food production to ensure sustainable technology development in terms of social and ethical as well as ecological consequences the core research is complemented by a comprehensive dissemination and communication package that targets all relevant stakeholders finally a clear exploitation plan including standardisation is described which will transition the automats from trl 5 at the end of the project to a product ready to impact the food packing industry four year after the end of the project
hydrogen public opinion and acceptance

hypop aims to raise public awareness and trust towards hydrogen technologies and their systemic benefits through a the preparation of guidelines and good practices that will help to define more effectively how citizens consumersendusers and stakeholders can be involved in the implementation of h2 technologies b the creation of a web platform collecting communication material mainly videos on new hydrogen technologies developed according to the early findings of the public engagement activitieshypop is led by envi an innovation accelerator for business with 20 years experience in the hydrogen sector hypop is represented by a wellbalanced consortium representing 6 countries national hydrogen clusters it b pl bg three research organisations ir es an agency for the promotion of european research itfour guidelines will be developed one more public oriented that will report on best practices to involve citizens the other 3 collecting the results coming from the involvement of stakeholders groups first responders permitting authorities certification body hypop will also contribute to the definition of indicators to be used for social life cycle assessment of hydrogen technologies and for this will focus on 2 applications residential and mobility which will enter into the daily life of people hypop will also be connected with some ongoing h2 projects characterised by demonstration activities in public spaces some of them have already been identified ie everywh2ere reflex h2ports remote they are well known to the consortium partners and have faced some barriers often due to a lack of specific reference cases for the authorities called upon to grant safety and other permissions for the installation or use of the demonstrators the hypop website aims to become the hosting site of similar videos explaining upcoming hydrogen technology currently under development and demonstration
sustainable energy harvesting systems based on innovative mine waste recycling

start project primary objective is to build an innovation ecosystem in the european union eu based on the development of sustainable and economically viable thermoelectric te waste heat harvesting systems to be applied in heavy industry and in maritime industry as well as primary power source for offgrid sensors and iot devices this objective will be achieved by incorporating abundant sulphides mainly tetrahedrite mineral series at present an environment hazard in mine tailings collected in five european countries in the production of advanced sulphide ptype te thermoelements in contrast current commercial te devices incorporate ptype and ntype te thermoelements that are produced from expensive and rare elements namely tellurium which is predominantly sourced in china the impact of start project approach on endorsing a more sustainable and resilient eu comes from three inputs first by reducing eus dependence on primary critical raw materials secondly through the promotion of circular economy processes that will create value in eu by building a strategic ecosystem based on a highabundant mineral just recently it was demonstrated by our team that the mineral was amenable to processing to single phase ptype tetrahedrite thirdly by the production of te energy harvesting systems offering a contribution to the reduction of fossil fuels consumption with a great impact on the increase of the overall efficiency of energy production and consumption systems as well as on the reduction of the greenhouse gas emissions for that start project aggregates research organizations with strong background and knowledge on geology materials science and renewable energies and industrial organizations that guarantee the entire production and exploitation supply chain
the social isolation and loneliness in europe network evidencebased policy recommendations on its causes consequences and monitoring

the lonelyeu project tackles the pressing societal issue of social isolation and loneliness sil across the eu through a unified strategy engaging stakeholders at every level lonelyeu aims at facilitating the exchange of knowledge and practices connecting sil stakeholders and supporting and encouraging decisionmakers to adopt targeted and evidencebased policies to prevent and mitigate sil on local regional national and eu levels the lonelyeu consortium combines scientific expertise policy expertise and networking and communication expertise from a diverse array of eu nations this consortium is guided by its evidencetoaction advisory board and supported by the who oecd and other global entities lonelyeu will work towards the five expected outcomes in three separate pillars in pillar 1 the empirical cornerstone lonelyeu will apply advanced statistical methods to analyze pooled existing data creating a comprehensive dynamic open accessible and sustainable evidence map that sheds light on the socioeconomic causes and impacts of sil at the individual and societal level in pillar 2 the policy foundation lonelyeu will craft the european social isolation and loneliness index establishing a groundbreaking framework to monitor sil across the eu pillar 2 will also draw on empirical findings from pillar 1 to provide evidencebased recommendations for preventing combatting and monitoring sil in europe at both individual and population levels in pillar 3 dedicated to networking and dissemination lonelyeu will leverage established networks to build the sil network europe an euwide network of sil stakeholders under the patronage of vice president evelyn regner and minister president hendrik wüst pillar 3 aims to execute a comprehensive impact strategy covering all steps of communication dissemination and exploitation to maximize the longevity of the project and its impact towards a more resilient and connected society
sorbonne university for a new deal on artificial intelligence

the european approach to artificial intelligence ai will build a resilient europe for the digital decade by fostering both excellence in ai and trustworthy ai this perspective invites us to ask the following critical questions how can we ensure the development of research that is centered on humans is in line with the social cultural medical climatic and sustainability issues that are becoming urgent how to sustain the competitivity of europe what are the skills needed for tomorrows leading researchers in aisoundai will answer to these questions through an ambitious research and training program the program driven by sorbonne university and its 30 educational research industrial and network partners will foster excellence in mobility training and career development of 30 international phd fellows together they will develop both fundamental and applied projects and crystallize the communitys efforts around 3 interdisciplinary and intersectoral programs 1 changing societies languages cultures 2 a global approach to health 3 resources for a sustainable planet an innovative scientific training supervision and secondment program will be developed it will be complemented by career development activities and training in transferable skills business and entrepreneurship open science gender ethics by using rich pedagogic methodologies tailored to each fellows needs soundai has an objective to guide a paradigm shift in the recruitment and training of doctoral fellows with longranging and significant repercussions by developing a thoroughly integrated phd program that more accurately reflects the current and future landscape of ai crucially enriching the human resources capital base in europe
hierarchical and agile resource management optimization for networks in smart energy communities

the main objective of harmonise is to provide an endtoend interoperable hierarchical solution to support encourage and scale up the transformation of traditional districts to positive energy districts peds through optimal design management and integration in an interoperable scalable and replicable manner following a usercentered approach from the technology business operation and social engagement perspectives empowering the transition towards the european super grid the consortium aims to offer a hierarchical approach integrating fogenabled devices cosimulation modules openstandard interfaces apis and openstandard system structure and parameterization ssp that will enable the connection with other tools and established networks additionally a user engagement app will be presented to support the development of active business models energy awareness and incentivize stakeholder involvement and entrepreneurship furthermore the consortium plans to introduce a transactive energy approach via a blockchainbased network that allows dynamic and secure smart contracts and energy exchange harmonise will support the management and expansion of multisectoral peds including electricity and heating networks res integration mobility schemes and energy storage problems by unifying energy transactions harmonise will be demonstrated in 4 physical pilots and 1 digital pilot case that will incorporate all the other cases to a super nova grid