Dragon09/odtu_chatbot huggingface dataset:
vernacular literature and medieval universities the birth of a new transnational literary identity france and italy 12201399

the rise of universities during the middle ages represented a major shaping factor leading to a paramount intellectual and cultural shift at a european scale changing the way to communicate to learn and to think medlunis purpose is to shed a light on how medieval universities shaped a european literary identity during their rise and growth between 1220 and 1399 this goal will be pursued by investigating representative case studies across france and italy where medieval universities became the core and the cradle of a new vernacular literary tradition establishing innovative paradigms in writing and spreading texts and knowledgethe scope of the project will be on the one hand to analyse how authors texts and manuscripts began moving more frequently and further away from one university to the other leading to the creation of literary networks all around europe on the other hand i will aim at outlining how vernacular literature had been influenced by a range of international literary markers related to universities new topics disciplines and stylesa deep transformation had been occurring that still needs to be examined thoroughly and systematically by romance philologists in addition medluni will propose a replicable analytical model that would be applicable to other literary traditionsaiming at filling a scientific and disciplinary gap medluni will also settle a new scientific network between universit ca foscari and university of fribourg that represent two hubs of excellence and methodological innovation in the field of romance philology while my previous international and scientific experience would allow me to lead medluni proficiently the mscaglobal fellowship would give me the paramount chance to act for the first time as a principal investigator which would represent a key feature and a leap forward to my professional path
scientific philosophy rise and fall of a european ideal 1850s1940s

sciphil provides an indepth historical and theoretical account of the rise and fall of the ideal of scientific philosophy sp in europe from the mid 19th century when the notion emerged to the 1930s with the first international congresses on sp and ww ii which put an end to the project it focuses primarily on five geographical areas france germany austriahungary england and italy with a foray into the russian contextit is original in two senses 1 it accounts for a neglected chapter in the history of european philosophy in all its transnational and transcultural scope as part of a multifaceted process of articulation of a european intellectual space at times characterized by the conflicting pulls of political nationalism and scientific internationalization and tragically punctuated by two world wars 2 it focuses on a decisive historical moment wherein the problem of relations between philosophy and the sciences emerged in its current configuration and constituted a burning issue that concerned the very scope and vocation of philosophy itself indeed from the 1930s onwards with nazifascism and wwii a sharp fracture between philosophy and science occurred worsened by the cold war years today in our age of specialist fragmentation the stakes in bridging this rift have never been higher can philosophy contribute to mending the fragmentation of knowledge or is it destined to merely be one discipline amongst others more than a century ago scientific philosophers were asking exactly this kind of question in fact sp is not merely an antiquated locution to indicate what we now mean by epistemology or philosophy of science which are specialized fields in the current academic division of labour on the contrary it denoted the high hopes of thinkers who overcoming the two cultures divide intended to take seriously the revolutionary scientific breakthroughs and set up a new beginning for philosophy reshaping its scope and methods
green valorisation cascade approach of fish waste and byproducts through fermentation towards a zerowaste future

valorish is a 42month action that aims to develop a computationallyassisted methodology for the design and implementation of a biorefinery with a cascade approach to valorise waste and byproducts from the fishing industry at trl 5 the target portfolio of products will be fish oil fish protein hydrolysates bacteriocins pigments vitamins collagen and calciumrich powder targeting food products additives supplements and nutraceuticals the cascade conversion processes will vary with the feedstock heterogeneity comprising pretreatment oil green extraction proteolytic fermentation protein hydrolysis fermentation with hydrolysates as substrate and a portfolio of downstream processes the proteolytic fermentation will be guided by computational biology using models to search new candidate enzymeproducing bacteria the fish protein hydrolysates obtained in the fermentation will be used first as food supplement due to their bioactive properties and second as substrate for supporting a second fermentation to obtain highvalue bioproducts namely bacteriocins and astaxanthin as food additives and vitamin b12 as food supplement novel genomescale metabolic models will be used to link substrate composition to the desired bioproducts via inspection of metabolic pathways and selecting optimal microorganisms in a zerowaste aim the fermentation sidestreams will be valorised bones by extraction and calcination and residual biomass by anaerobic digestion all the bioproducts will be analysed for chemical nutritional bioactive and safety properties to comply with eu regulation and will be included in foodnutraceutical formulations and validated by end users a mathematical model will be developed to simulate the biorefinery and to support the satisfactory scaleup of the core processes as well as the assessment methodologies technoeconomic environmental standardisation social impact and acceptance of the products will be also assessed
imaging of muscle shape changes during electricallystimulated contractions

when we move our muscles contract and by doing so change shape while such shape changes are obvious and are required for a muscle to increase its force we know little about its functional role in force production muscle force is one of the most important parameters in the science of movement yet it remains impossible to measure in humans understanding the precise link between muscle shape changes and muscle forces and advancing methodologies for measuring such muscle shape changes can thus have an important fundamental and ultimately also clinical scientific impact in imuscle i propose to first advance innovative techniques for measuring whole muscle shape changes during muscle contractions and secondly to use these advancements to answer key questions about 3d muscle shape changes and its role in force production i will take an in situ approach to study the calf muscle of guinea fowl numida meleagrisis l i will stimulate the muscle to induce steadystate contractions at different muscletendon unit lengths at different activation levels and during concentric and eccentric dynamic contractions i will measure the muscle shape changes by using stateoftheart imaging modalities ie ultrafast computed tomography 2s and highspeed stereo 3d xray videography up to 750 hz while also recording muscle forces the shape changes will be assessed i when the muscle is activated globally and ii when the muscle is activated locally in specific parts of the muscle the latter is relevant given that we often activate only parts of our muscles for example during walking or when using electrical muscle stimulation for rehabilitation purposes gaining a better understanding of how muscles change shape under realistic conditions and how it is linked to muscle force is critical for treatment of neurological disorders affecting muscle contraction patient rehabilitation following injury or surgery and development of bioinspired robotics
segregation of opportunities pathways to marginalization through neighborhoods and peers

social and economic exclusion is a major challenge worldwide attracting substantial research efforts across various disciplines yet research has been largely unsuccessful in providing robust knowledge that can promote inclusion one key reason is that marginalization is a multifaceted challenge that cannot be tackled within disciplinary boundaries segop will push the research frontier by integrating perspectives and methods from sociology psychology behavioral genetics and economics my main objective is to provide nuanced knowledge about how marginalization processes unfold through interactions between family background individual characteristics and neighborhood and peer characteristicswith segop i will lead an interdisciplinary team of researchers we will leverage uniquely rich populationwide register data linked with largescale survey data on nuanced developmental mechanisms and outcomes as well as molecular genetic data together we will1 investigate stability and persistence across different aspects of marginalization and forecast which children and youth will experience persistent longterm marginalization2 discover when why and for whom neighborhood and peer processes during childhood and youth lead to marginalization 3 uncover whether intergenerational transmission of disadvantage occurs through segregated opportunitieswith surging inequality growing socioeconomic achievement gaps and increasing neighborhood segregation there is an urgent need to understand pathways leading to marginalization my interdisciplinary research profile broad research background and expertise in quantitative methods make me uniquely suited to lead this timely project by integrating fragmented disciplinary perspectives i have the groundbreaking opportunity to unravel mechanisms leading to marginalization this knowledge will inform policy with the potential to reduce barriers to inclusion and give all children equal chances to succeed
intramitochondrial seeding and sorting of protein aggregates

quality control processes maintain mitochondrial health enabling cellular functions such as bioenergetics metabolism ca2 signaling and cell death regulation mitochondrial proteases unfolded protein response asymmetric fission vesicle shedding and mitophagy all contribute to organelle quality however the specific triggers for these processes remain unclear while unfolded protein accumulation appears to be a common trigger the mechanism by which it initiates diverse responses remains uncertainto investigate this question we developed advanced tools for realtime imaging of protein aggregation in mitochondrial subcompartments aggregates in the matrix and intermembrane space induce mitochondrial fission and elicit distinct functional responses based on their location live imaging revealed that intermembrane space aggregates initially seed in the mitochondrial midzone and then sort through transient sidebyside fusion with neighboring mitochondria in the matrix aggregates seed at one pole and are selectively sorted to daughter mitochondria through asymmetric fission our preliminary experiments unveiled an early seeding and sorting process of protein aggregates according to their intramitochondrial locationin the integrate project we aim to comprehensively understand the underlying principles and consequences of this process by combining advanced imaging techniques omics analysis biochemistry functional assays and unbiased screenings we will decipher the rules governing aggregate formation seeding sorting cellular fate and response in various mitochondrial subcompartmentsintegrate seeks to establish the occurrence and downstream responses of this newly discovered early phase of mitochondrial quality control clarifying this fundamental mechanism will provide insights into mitochondrial and cell biology with significant implications for pathological conditions and aging where mitochondrial quality control is compromised
a direct sensorimotor connection with the spared neural code of movement to regain motor function

many individuals suffer partial or complete muscle paralysis with no available cures even though neural interfaces have the potential to restore motor function with assistive systems their use is still very limited even in the case of stateoftheart invasive neural implants the control of the movements of the paralyzed limbs is highly unsatisfactory these neural interfaces suffer high surgical risks poor control of the activity of spinal motor neurons and inaccurate mapping of the attempted movements spinal motor neurons are the last cells of the nervous system that convert motor commands into movement and their activity can be accessed with minimally invasive methods in most neural lesions such as spinal cord injury and stroke there are functionally active spinal motor neurons projecting to paralyzed muscles that are modulated by brain input in this project i propose a bidirectional interface that is driven by the realtime identification of efferent spinal motor neuron activity we will develop novel sensing decoding and feedback methods with precise cellular resolution this neural interface will map engage and augment the spared output of the spinal cord through new deep learning methods and hundreds of finetuned electromyographic sensors recording action potentials of individual motor units for the muscles controlling the hand the output of this interface will enable highly accurate temporal associations between efferent motor neuron activity and sensorimotor feedback by delivering multiple visual and somatosensory inputs this bidirectional neural interface will entrain and monitor the spared neural pathways at the direct cellular level with the goal of transforming and augmenting the activity of the spared motor neurons into highly functional motor dimensions using these new technologies we aim to answer open questions in movement neuroscience and spinal cord injury
insights into a maritime world understanding indian ocean trade through an old tamil littoral narrative

maritamil seeks to unravel the economic and historical significance of old tamil literary sources composed in the ancient south indian royal courts which actively engaged in the indoroman trade between the 1st and 4th centuries ad this epoch marked a pivotal juncture in the regions history as evidenced by the rich literary heritage of the old tamil cakam corpus since the economic opportunities inherent in trade relations led to the emergence of early kingdoms and triggered their economic rise the project aims at preparing a new critical edition of the text called paiapplai from the surviving manuscripts palmleaf and paper accompanied by an exhaustive philological and historical analysis this unique source provides a window into the life of pukr a port on the southern shores of india where according to the tamil texts greek ships arrive laden with precious gold and depart carrying the coveted cargo of pepper the goal is to rethink our conception of early tamil history and maritime trade with the countries participating in indian ocean trade by bringing together sources kept apart and utilised by separate disciplines such as history of literature history and archaeology a new annotated translation will introduce this text to the international research community engaged in indoroman trade and highlight it as a crucial source text for analysing the monsoon asia region in antiquity
dissecting the cancer epigenome fundamental lessons from developmental biology

dna methylation is a tightly controlled mechanism that is essential for normal development and genome regulation although maintained in a highly static pattern across healthy tissues dna methylation is globally reprogrammed in nearly all malignant cancers including gains at thousands of gene promoters and global loss across large domains substantial work from our group to characterize multiple primary tumor cohorts transgenic animal models and cancer cell lines finds that current experimental systems rarely if ever capture key features of the cancer epigenome in contrast our parallel efforts to understand epigenetic dynamics in development suggest an alternative highly innovative hypothesis with a clear path for investigation we find that the epigenetic alterations in cancer very closely mirror patterns that emerge in the early placenta a tissue that naturally acquires invasive immune suppressive angiogenic metabolically plastic and mutationally tolerant properties notably this cancerlike epigenome depends on dynamic previously undiscovered configurations of regulators that can be triggered without genetic mutation with these insights we have innovated tractable in vitro and in vivo platforms to dissect the biochemical genetic and physiological properties of this unique form of genome regulation as it supports developmental processes we believe these efforts will demonstrate that the placenta and by extrapolation the cancer epigenome reflect a switchlike reprogramming event that can be studied at high resolution in line with the ercadg programs goals we will pursue ambitious and critical questions resolve longstanding paradoxes and provide a complete model of epigenetic transformation in development with direct disease implications our worldclass interdisciplinary team extensive preliminary data experimental design and proven trackrecord will enable us to turn this grant into highimpact and translationally relevant discoveries
chemometric histopathology via coherent raman imaging for precision medicine

the charm project aims to radically transform the cancer diagnosing process and bring the emerging field of digital histopathology to the next level introducing a novel technology for tissue analysis capable to measure the molecular composition of the patient tissue samples and to recognize and classify the tumor in a completely labelstainfree way the instrument integrated with artificial intelligence ai will offer to histopathologists a reliable fast and lowcost clinical decision support system cdss for cancer diagnosis and personalized cancer therapy we will develop a class c ivdr invitro diagnostic regulation medical device consisting of a turnkey lowcost broadband coherent raman scattering crs microscope enabled by our patented graphenebased fiber laser technology named the chemometric pathology system cps integrating an ai module based on deep learning statistics and machine learning the cps will be capable of automatically analyzing unstained tissues providing fast and accurate tumour identification differentiating normal vs neoplastic tissues with accuracy 98 and final tumour diagnosis prediction differentiating and grading histologic subtypes with accuracy 90 thus offering to the histopathologist a decision tree compatible with existing clinical protocols but with biomolecularbased objectivity and reduced time to result trl6 we will develop a robust business case for the application and ensure the project continuation to higher trls and the final market entrance this proposal builds on the results of the erc poc project gsyncor
harnessing forest genetic resources for increasing options in the face of environmental and societal challenges

forests are key elements of the european bioeconomy to enhance provision of their ecosystem services es harnessing forest genetic resources fgr is essential optforests will support the conservation and sustainable use of fgr by i conducting research on the selection of diverse forest reproductive material frm including mixtures adapted to future climates ii fostering sustainable use and resilience of natural forests iii helping expand and diversify nursery production iv developing naturebased solutions nbs tools eg expanded information systems and cultural trajectories to promote forest biodiversity and es and v demonstrating biodiversity restoration solutions to do this optforests will carry out genetics modelling stakeholder surveys expert panels and socioeconomic analyses optforests will evaluate adaptive and biomass traits in existing common gardens and newlyestablished nextgeneration ones conserve and utilise unique tree lineages for ecosystem restoration and management model future adaptation of trees at different life stages and conduct lowinput breeding this will be complemented by studying the effects of silviculture and landscape heterogeneity on genetic diversity and developing new silvicultural options for genetically mixed forests which will be implemented via training software marteloscopes and longterm demonstration plots to enable optimal supply of diversified frm optforests will assess the european nursery sector forecast future frm needs develop plant production technology and promote cooperation between nurseries to ensure the uptake of nbs they will be codesigned with local and eulevel stakeholders and a costbenefit and gap analysis of key socioeconomic governance and policy issues will be developed finally the optforests tailored communication strategy will be instrumental in achieving longterm impacts supporting international and eu policy under the european green deal
autonomous longtime aquatic biodiversity and ecology monitoring robot

the biodimobot project will deliver a system for autonomous longterm robotic assessments of aquatic biodiversity and ecology this project will develop an innovative measurement system to monitor biodiversity and provide insight into the drivers of ecosystem degradation additionally it will assess organismic and environmental stress levels by using novel biohybrid sensors with the biodimobots ability to perform autonomous and automated multimodal longterm data collection the project will create a userfriendly robotic tool that provides detailed insights into the ecological health of aquatic environmentsthe project will be driven by the needs of potential stakeholders such as researchers small and mediumsized enterprises smes in waterrelated industries and policy makers field operations will demonstrate the transformative power of the biodimobot systems by monitoring aquatic ecosystems over a long period of time the collected data will be highly accessible to enable interdisciplinary collaboration between scientists society and policy makers we will respond to the need to disseminate the new methodology to a wide audienthe proposed biodimobot project aims to enhance biohybrid sensors focusing on biodiversity measurement key goals include tailoring sensors for comprehensive water column investigation ensuring longterm autonomy establishing efficient data transfer and integrating classical aquatic and biohybrid sensors for ecosystem evaluation the robotic system comprises a surface unit with solar cells for energy and communication a ground unit for microbial activity investigation ropes connecting these elements and ropeclimbing modules with additional sensors for sampling this integrated system offers a precise and adaptable solution for biodiversity monitoring emphasis will be placed on advancing the concept of biohybrid robots through market analysis stakeholder engagement and company founding