Dragon09/odtu_chatbot huggingface dataset:
acoustofluidic thinfilm actuated chip for exosome separation from blood

acousome is a consortium stemming from the ongoing eicfet open biowings project and consists of four of the biowings projectpartners acousort ab dtu lund university and day one srl acousome has the ambition to build on the disruptive technology ofthin film actuated acoustofluidics developed in biowings the results obtained in biowings will be combined with a polymeracoustofluidics technology developed in the ongoing eurostars acouplast project to fabricate a polymerbased microfluidic chip forseparating and enriching exosomes from blood for use in the next generation of pointofcare diagnosticsexosomes are nanosized extracellular vesicles that are released by a significant number of different cell types they are considered animportant biomarker with high diagnostic potential in a wide range of diseases including different kinds of cancer glioblastomamelanoma prostate cancer and many others hepatitis kidney cardiovascular and liver diseases therefore there is an increasinginterest in exosomes as a powerful diagnostic tool having the opportunity to isolate and analyze exosomes from a routine blood testis crucial for early detection of a wide range of diseasesin the acousome chip exosomes will be separated and enriched from blood by combining two steps already developed by lunduniversity and acousort first plasma will be separated from blood by flowing the blood through a microfluidic channel pushing thecells towards the centerline of the channel using ultrasoundand and subsequently splitting the cell and plasma flows exosomes willthen be trapped and enriched from the plasma flow using a localized acoustic field the acoustofluidic chip will be driven usingthinfilm actuators as invented together with dtu in the biowings project the exosome separation cartridge is intended for samplepreparation in research labs and future diagnostic pointofcare instruments
rational and simulationsupported design of inhalable rna nanocarrier

the overarching goal of ratinhalrna is to computationally predict and develop efficient formulations for pulmonary rna therapy new rna formulations are imperative for clinical rna delivery beyond the liver the lung offers undruggable targets which could be treated with rna therapeutics however approved sirna formulations are not suited for pulmonary delivery due to instability in lung surfactant and during nebulization hence it is my aim to rationally design inhalable and biocompatible polymerbased sirna formulations for efficient sirna delivery to the lung while biomaterials are commonly optimized empirically via onevariableatatime experimentation i am the first to combine designofexperiments doe with molecular dynamics md simulations and machine learning ml to accelerate the discovery and optimization process of sirna nanocarriers towards the metrics of gene silencing efficacy and biocompatibility at reduced wetlab resources in ratinhalrna i will synthesize amphiphilic polyspermines and will prepare sirnaloaded nanoparticles by microfluidic assembly for experimental assessment of physicochemical parameters as well as in vitro and in vivo gene silencing efficacy in coronavirus infection models i will assess sirna binding of the polyspermines via md simulations and will analyze the contribution of the nanoparticle design factors on experimental and computational readout responses of the doe i will train a support vector machine for supervised ml and will generate models to identify areas of interest based on the predictions i will test additional formulations to obtain a validation dataset for the assessment the ability of the ml algorithm to identify design properties of efficient sirna nanoparticles for pulmonary delivery ratinhalrna will enable me to predict favorable sirna nanoparticle characteristics in the future prior to polymer synthesis thereby reducing experimental work and improving sustainability and animal welfare
the global ocean carbon cycle after peak emissions dynamics and process attribution in a seamless model framework from coastal shelves to the open ocean

atmospheric co2 levels are 49 above preindustrial levels due to anthropogenic co2 emissions the ocean takes up 25 of these emissions and thereby mitigates climate change the global carbon budget annually quantifies the atmospheric co2 sources emissions and sinks eg ocean uptake and i coordinate its ocean co2 sink estimate the uncertainty of the ocean sink estimate is huge the range of estimates is 25 times larger than the co2 emissions of the eu27 it is unknown whether the ocean sink has grown or stagnated since 2016 and yet we face an even larger challenge with the imminent transition to a new regime in the past the ocean sink was controlled by fastgrowing atmospheric co2 after peak emissions atmospheric co2 will grow slower stagnate or even decrease i hypothesize that the dynamics of the ocean carbon sink will then be fundamentally different and poorly quantified ocean ventilation processes will be even more important ventilation transports carbon to the deep ocean and is the bottleneck of the ocean sinkoceanpeak will establish a gamechanging forecasting capacity of the truly global ocean co2 uptake in societallyrelevant lowemission scenarios oceanpeak will go beyond the surface and open ocean estimate with a seamless transition to coastal shelves and from surface to depth with a unique multiresolution ocean carbon cycle model i will1 develop a seamless coastal shelf to open ocean carbon cycle model and groundtruth ventilation processes based on newlyemerging observations to robustly quantify the ocean carbon sink to date2 characterize the dynamics of the ocean carbon sink under regimes after peak emissions3 attribute the evolution of the global ocean carbon sink to processes and quantify the timescale of carbon sequestrationquantification and understanding of the ocean sink from coastal to global scales will be paramount for an independent monitoring system of greenhouse gases as foreseen in the paris agreement
trustworthy multisite privacy enhancing technologies

in recent years federated learning fl has emerged as a revolutionary privacyenhancing technology and consequently has quickly expanded to other applications however further research has cast a shadow of doubt on the strength of privacy protection provided by fl potential vulnerabilities and threats pointed out by researchers included a curious aggregator threat susceptibility to maninthemiddle and insider attacks that disrupt the convergence of global and local models or cause convergence to fake minima and most importantly inference attacks that aim to reidentify data subjects from fls ai model parameter updatesthe goal of trumpet is to research and develop novel privacy enhancement methods for federated learning and to deliver a highly scalable federated ai service platform for researchers that will enable aipowered studies of siloed multisite crossdomain cross border european datasets with privacy guarantees that exceed the requirements of gdpr the generic trumpet platform will be piloted demonstrated and validated in the specific use case of european cancer hospitals allowing researchers and policymakers to extract aidriven insights from previously inaccessible crossborder crossorganization cancer data while ensuring the patients privacy the strong privacy protection accorded by the platform will be verified through the engagement of external experts for independent privacy leakage and reidentification testinga secondary goal is to research develop and promote with eu data protection authorities a novel metric and tool for the certification of gdpr compliance of fl implementationsthe consortium is composed of 9 interdisciplinary partners 3 research organizations 1 university 3 smes and 2 clinical partners with extensive experience and expertise to guarantee the correct performance of the activities and the achievement of the results
advancing aerospace composites through induction welding and new vitrimeric formulations enhanced by integrated photonic sensors providing data to digital supply chain shm maintenance

the composites aerostructures market is projected to grow to 116 billion by 2030 attributed to the increasing demand for advanced materials in aircraft manufacturing which exhibit lightweight properties and can withstand harsh environments ultimately improving the aircraft performance and cost savings pleiades project aims to address these needs making significant steps towards meeting the industrys requirements through its proposed solutionpleiades is bringing together different disciplines and key technologies that will contibute in advancing further composite aerostructures and promote the digital transformation in aviation pleiades multiple disciplines extend across a wide variety such as formulations and characterisation of new composite materials automation of induction welding processes for composites leveraging integrated sensing disassembly of composites joints healing and maintenance schedules these will be complemented by the development of passive pic based multi sensors the development of a unified qashm methodology the extensive modelling for induction welding and the development of material healing damage propagation and deicing models all of these disciplines will be pursued within pleiades and with tangible use cases by the aerospace in synergy with clean aviation partnership to ensure its innovations are aligned with itthe technological advancements of pleiades will address the needs for highvolume sustainable manufacturing with integration inspection and recycling and circularity in the aerospace industry it is expected that by making full use of the new technologies that promote sustainability and circularity cost savings of at least 3040 can be achieved within the project a maintenance and repair protocol will be developed as well as an innovative shm methodology finally the digital twin developed will contribute to the advancing of the digital research infrastructure in accordance with clean aviation
reconstructing fragmented bones reconstructing fragmented lives

human skeletal remains can offer key information on diverse aspects of past life but like all archaeological materials they only give a glimpse into the life of past individuals hence a fragmented perspective into our ancestors lives their interpretative potential is greatly inhibited by the fact that such remains are often found fragmented due to several anthropogenic and natural taphonomic agents such as funerary treatment animal activity soil pressure and others this fragmentation severely limits the information that may be extracted from human bones in terms of metric analysis geometry and morphology reconstruct aims at producing 3d morphable models for the main elements of the lower and upper limbs of the human skeleton which will be then used to infer the missing morphology of fragmented or incomplete bones in order to achieve this aim and address a major current limitation in human skeletal analysis reconstruct will integrate approaches from osteoarchaeology forensic anthropology biology engineering and data science the results of the project will maximize the information that may be extracted from bioarchaeological research contributing to a more comprehensive assessment of past life parameters reconstruct will also have major implications in forensic anthropology since the study of modern skeletal remains suffers from similar limitations in terms of partial preservation as those witnessed in archaeological bones finally the source code and raw data emanating from reconstruct will be made open access greatly enhancing the extension of this approach to zooarchaeology palaeoanthropology and the prosthetic implants industry
reinforce the ethical and regulatory ecosystem for the transformation of clinical trials oversight in ethiopia tanzania and beyond

why rercto the conduct of clinical trials requires competent ethics committee and regulatory authorities that can review clinical trial applications and monitor processes independently and efficiently ensuring the safety of clinical trial participants and the integrity and reliability of the generated data the capacity of most african regulatory authorities regarding clinical trial review and oversight is weak due to poor infrastructure limited resources both human and financial lack of expertise unconducive working framework and lack of systems adequately supported by technology collaboration between academia international organizations national ethics committees necs and national regulatory authorities nras are mandatory to produce sustainable regulatory skills and functional clinical trial oversight systems the rercto consortium consists of a group of well reputable clinical trial researchers regulatory authorities ethics committees universities and research institutes in ethiopia tanzania norway and sweden our aim is to achieve ethics and regulatory excellence and harmonization in subsaharan africa in clinical trial oversight cto by improving the legal and policy framework by identifying gaps and making recommendations improving regulatory and research ethics oversight capacity and capability by digitalising the clinical trial oversight systems and developing training programs to strengthen competency of relevant stakeholders and strengthening local regional and international collaborations and coordination of necs and nras for clinical trial oversight by developing joint clinical trial review guidelines these efforts are geared towards increasing clinical trials in subsaharan africa standardization of clinical trial review and monitoring processes and promoting ownership efficiency linkages for data sharing transparency and accountability of clinical trial review processes
bioinspired and advanced fibres and materials for sustainable outdoor textiles with biomimetic functionalities

penguin aims to develop sustainable materials for outdoor garments its highlight lies on cellulosebased fibres for producing sustainable insulation material that mimic the way penguins protect themselves against cold and moisture on land the goal of penguin is to ensure europes role as a worldleading technology provider and research leader in the textile sector through collaboration between europes leading experts in advanced material value chain and reduce the environmental impact of the outdoor garment industry and address sustainability and ethical concerns of consumers specifically penguin aims to develop sustainable and recyclable textile fibres based on wood cellulose with enhanced hydrophobicity adhesion and tailored morphology to create ethically responsible and sustainable insulation materials for textiles penguin will develop fabrics that incorporate advanced biomimetic functionalities and digital tools for optimal performance the reuse and recycling plan together with developed recycling technologies will ensure that the endproduct is disposed of responsibly further contributing to the circular economy furthermore penguin aims to ensure that the developed textile materials are safe and sustainable lowcost and lowresource and gain market adoption and stakeholder acceptance for the new products penguin will achieve these objectives through innovation activities and partnerships optimizing developing and validating new materials and production methods overall penguin has the potential to transform the textile industry by creating sustainable efficient and highperformance textile materials penguin will contribute to industrial leadership increased autonomy in strategic value chains and security of supply in raw materials for resilient industry
achieving ecological resilient dynamism for the european food system through consumerdriven policies socioecological challenges biodiversity datadriven policy sustainable futures

the ecoready project will develop a realtime surveillance system an observatory offered as an eplatform and as a mobile application this will function as the necessary singular source of information provide realtime assessments for the food system and update forecasts frequently and consistently the observatory will be available to society policymakers the scientific community and the agrifood industry and integrated with a network of 10 living labs supported through the third party funding process covering all bioclimatic regions in europe forming the ecoready project knowledge infrastructure ecoready will produce knowledgebased resilience strategies and develop tools that will be embedded on the observatory the underlining principle behind the ecoready approach is resilient dynamism or tackling immediate problems and longterm challenges at the same time the living labs network will facilitate concept to action through the cocreation of scenarios addressing their regional needs the development of policy recommendations contingency plans and resilience strategies and embed them on the observatory furthermore ecoready will develop an early warning system and decision support tools using innovative artificial intelligence based on holistic prediction models and life cycle assessment results ecoready will ensure that european farmers and societys interests be reflected in future policymaking and monitoring through earlystage active engagement incorporating bottomup recommendations facilitated by the increased usership of the digital tools developed and resulting in increased awareness for climateadaptive and mitigating agrifood products furthermore the observatory smart application will include tools that will empower the citizens to actively engage in policy making and interact directly with the scientific community farmers and industry and policy makers thus driving change in consumption habits
precommercialization of new generation atomiclayerdeposited lasers for future green highperformance data centers

the continuous growth of global data traffic pushes the data center technology boundaries and their energy consumption data centers already use more than 2 of the global electricity and are expected to consume 20 by 2025 the new generation hyperscale data centers offer a more energyefficient alternative to conventional data centers but are limited by the current technology restrictions silicon photonics has been deemed to solve current bottlenecks for building green hyperscale data centers however this technology is challenged by the complicated and expensive fabrication methods of the laser sources which represent 40 cost of the entire silicon transceiver market using a simple fabrication method invented in our erc advanced project we have designed a waveguide light source that can be fabricated onto the siliconintegrated platform with a singlestep straightforward lowcost lowtemperature and scalable process that lowers the fabrication cost 10 times compared to the stateoftheart light sources such technologic breakthrough will push the implementation of silicon photonics in hyperscale data centers allowing them to maintain a low energy footprint while meeting the everincreasing bandwidth requirements of the growing big data societal challenge our project aims to further develop the novel technology and demonstrate its effectiveness for data center applications to create the firstofitskind lowcost and scalable fabrication technology for the silicon photonics market compatible with the current systems used in the industry furthermore we will prepare and validate the business concept with value chain players strengthen our ipr strategy and prepare the commercialization to establish a startup aiming at serving this significantly growing market 40 compound annual growth rate
solving the scaling challenge of the memory industry highspeed lowcomplexity and lowcost nonvolatile ferroelectric memory fenvram made in eu

the semiconductor industry is a 600b industry the share of semiconductor memories is 150b but there are no memory manufacturers in europe so the eu is missing out on a huge share of the semiconductor marketfmc will change that by creating fundamentally new memories based on our disruptive material innovation we will become a major memory player from europe reducing the eus critical dependence on overseas suppliers creating jobs and making semiconductors greenerour memory is as fast and low cost as dram while providing nonvolatile data storage our memory products will significantly reduce the energy consumption of data centers enable instanton capabilities and double the battery life of smartphones pcs and iot devices in addition nonvolatile working memory immediately protects against data loss due to power outagesour vision is to disrupt the memory industry and become the first eu memory company set up production facilities in europe to become the next eic unicorn
central and eastern european security cooperation cluster

in the wake of russian aggression against ukraine the position of central and eastern europe cee in the security architecture of the eu has become crucial however the voice of security research from the region is not well represented in security debates on the european and global level the international institute of political science iips of masaryk university muni is perfectly positioned to address this disbalance with its unique expertise of cee in terms of area studies and outreach to policy sector by twinning with leading european research centres in security and area studies peace research institute oslo prio and aleksanteri institute at university of helsinki uoh we seek to develop a promising research avenue focused on security cooperation and integrate the iips in international networks supported by horizon europe we will follow three specific objectives 1 strategic networking coordination of muni prio and uoh research on security cooperation and building a pathway for sustainability through systematic development of followup projects 2 developing culture of excellence at iips for both researchers and research managers and administrators rmas delivering a research programme training and knowledge exchange empowerment of young researchers and female researchers 3 developing pathways to societal and academic impact in the field of security cooperation our actions will transform iips at muni into a hub for international intersectoral and interdisciplinary collaboration on security cooperation beyond that the training networking and integrative actions will help transform the broader environment for research in political science and international relations at muni making it a recognized and attractive place to seek careers in research finally and ultimately we will contribute to bringing cee from the periphery of security discourse towards the centre making the eu security policy more balanced and inclusive