Dragon09/odtu_chatbot huggingface dataset:
digital agriculture and forestry understanding the market to forecast and support future growth

4growth aims to contribute to the uptake of digital and datadriven solutions in agriculture and forestry by i documenting the current stateofplay and projecting the future evolution forecasting and foresight of the sector ii making insights available to the wider community of decision makers and value chain actors through the 4growth visualisation platform iii collecting a wide range of ground truth data and identifying key factors or constraints for uptake and iv producing sets of key policy recommendations and best practices to encouragefacilitate further uptake to successfully fulfill its ambition and carry out the proposed activities 4growth brings together a highlymotivated team of 13 partners from 9 eu member states with strong proposition and extensive involvement in digital agriculture and forestry activities
making timeresolved cryoem available for the community of structural biologists validate improve derisk

knowledge of protein structure is fundamental for the understanding of biology disease mechanisms drug development and biotechnology recent progress with electron cryogenic microscopy cryoem simplified and tremendously accelerated the determination of protein structures including multiple protein conformations many functionally important protein conformations and proteinprotein complexes are transient and are not easily accessible by conventional cryoem these transient states can however be freezetrapped and their structures solved to high resolution using the timeresolved cryoem trem despite its long history and high interest from the cryoem community technical difficulties prevented the spread of the methodology and no commercial devices enabling trem sample preparation exists during the erccog project we developed a new approach to the preparation of trem samples which has advantages over the other reported technologies in this poc project we propose to undertake steps that will explore the suitability of our technology for application to a wide variety of protein samples and to evaluate the commercial potential of the technology with aim of bringing it to cryoem users rapidly to achieve this we plan to 1 expand the number of protein samples to be tested on our instrument thus enabling rapid user access and simultaneous validation of the methodology 2 perform additional research to further improve the method by addressing the remaining bottlenecks 3 make steps towards defining the best process and materials for industrial production of microfluidic chips and 4 redesign the timeresolved plunger into a compact preindustrial prototype these steps will broadly validate improve and derisk the technology to make it more attractive to cryoem instrumentationmaking companies to bring the technology to the cryoem community
nanofluidic chips for reproducible cryoem sample preparation with picoliter sample volumes

cryogenic transmission electron microscopy cryoem is a technique for highresolution imaging of radiationsensitive biological macromolecules under nearnative conditions cryoem sample preparation techniques rely on rapid cooling of an aqueous suspension of biological macromolecules to obtain a thin layer of amorphous ice containing the solute problems associated with current implementations are considered a major bottleneck to realizing the full potential of cryoem excessive sample consumption the difficulty to reproducibly obtain ice conditions suitable for highresolution imaging and the extensive contact of solute molecules with a large airwater interface result in only a small fraction of the imaged molecules contributing useful information for the final 3d reconstruction poor time resolution of these methods furthermore precludes the visualization of dynamic structural changes that provide critical biological insight in our laboratory we have developed technology to design nanofluidic mems devices suitable for cryoem imaging we here propose to explore product development of a nanofluidic chip for reproducible sample preparation with picoliter volumes the sample is contained in nanochannels formed between membranes of an electrontransparent material thereby controlling ice thickness and avoiding formation of an airwaterinterface this method has all features to push cryoem to new frontiers it requires minute amounts of sample robustly provides uniform and customizable thickness gradients across the sampling area at a time resolution that is limited only by the vitrification process itself our cryochip will provide entirely new opportunities for timeresolved cryoem imaging and highthroughput applications in structurebased drug design for pharmaceutical industry we will liaise with an industrial partner experienced in mems probe fabrication to explore processoptimization and viability of largerscale production
climate change and air contamination artificial intelligence applied on the correlation between air pollutants and noncommunicable respiratory diseases in europe

the climair project will expand the evidencebased understanding of climate change air pollution and noncommunicable respiratory diseases by using artificial intelligence ai tools it will gather data on greenhouse gases levels and disaster risks information on serious air pollutants and respiratory diseases prevalence the aipowered tools will be employed to generate better intervention methods and improve public health outcomes federated learning fl will be used to develop ai models to protect patients privacy by raising public awareness and delivering the climair tool specifically designed to health workers urban planners and policy makers the project aims to influence policy decisions promote healthier environments and reduce respiratory diseases in europe which will be tested and validated the climair tool in specific municipalities that are part of the project climair draws on a consortium of 21 partners from 15 european countries including carefully selected health centres across europe in spain luxembourg ukraine italy france germany greece romania and poland focused on respiratory diseases which will provide disease data and explore metabolic routes of the studied contaminantsdiseases climair is composed of an interdisciplinary team formed by research centres ethical ai and modelling experts ssh specialists municipal governance and a communication dissemination cd expert team dedicated to achieving and spread the results of the project
new foundations for realworld cryptography

almost half a century after the invention of publickey cryptography there is still a vast discrepancy betweenthe theory and practice of cryptography with some notable exceptions research from the cryptographic theorycommunity focuses on problems of great theoretical interest albeit completely disconnected from the real world on the other hand widely used realworld cryptographic protocols are being neglected because they are either mathematically ugly their solutions appear uninteresting or they simply do not cross the mind of theoreticians the current state can be summarized as follows several wellestablished theoretical cryptographic concepts fall short from properly modeling the way practitioners think about realworld cryptography there exists a surprisingly large amount of modern cryptographic primitives and standards with unclear provable security statusthe central objective of the reworc project is thus to narrow the gap between theory and practice of cryptography providing a solid theoretical groundwork for realworld cryptography to this end we will lay a new theoretical foundation for realworld cryptography in the elliptic curve setting develop new tools and models for the design and analysis of practical cryptography in the postquantum setting revisit the concrete security of legacy cryptography from the 2000s recently established standards and forthcoming standardsreworc will have a substantial longterm impact on theoretical protocol design influence ongoing standardizationefforts in postquantum cryptography and settle doubts about the security of important cryptographyused in practice
centre for digitalisation of biology towards the nextgeneration of biosustainable products

biosustainablility is an important goal for humanity as it addresses many global challenges we face we need convergence of different technologies and domains to tackle challenges of biosustainability and combination of digitalisation and biotechnology provides a powerful opportunity for this while engineering of biology has delivered sustainable products highthroughput generation of biological data has outpaced our capacity to learn from it digitalisation of biology however through exhaustive analysis of big data using integrated informatics approaches promises to deliver nextgeneration bioengineering solutions towards a green economy these range from healthcare to biomaterials new foods and sustainable energy to foster digitalisation of biology we propose a teaming partnership between the novo nordisk foundation centre for biosustainability at the technical university of denmark dtu and the estonian centre for biosustainability ecb that links leading universities of estonia university of tartu and tallinn university of technology the digibio project will significantly upgrade the ecb and will create a research and technology platform for datadriven disruptive bioengineering solutions to accelerate translation of science to manufacturing of nextgeneration bioproducts the platform relies on complementary actions of partners for the generation and analysis of big data through integration of automated genome engineering phenotype screening highthroughput analytics and informatics it combines knowledge and techtransfer of a unique concept for digitalisation of biology and personnel training developed by dtu to ecb a bioengineering hub of estonia and the success story of it commercialisation and competence of estonia the project is aligned with the focus and smart specialisation areas of estonia and aims to enhance regional development by extending the biosustainable research and industrial practices of denmark into the baltic region
aibased leukemia detection in routine diagnostic blood smear data

acute promyelocytic leukemia is an extremely aggressive blood cancer where immediate diagnosis can determine life or death the diagnostic state of the art is manual inspection of a patients blood smear under the microscope by trained cytologists it is prone to human error and time consuming a risk factor in notoriously understaffed laboratories supporting clinical decisions with ai will drastically increase diagnostic speed and accuracy benefit patient survival and free up valuable expert time this is particularly important for cytological and histological analysis whose market size is expected to rise by a compounded annual growth rate of 147 in coming years yet so far the proof of concept that ai can be effectively employed for leukemia detection in routine diagnostics is missingi will leverage the methodological advancements in deep learning and explainable ai the skills of my erc cog funded research group and the expertise and data of the munich leukemia laboratory mll the largest leukemia laboratory in europe and my long standing industry partner together we will develop and implement leukoscreen an aibased software to automatically identify and flag up acute leukemia cases from mlls routine laboratory input this will decrease the diagnosis to treatment time of critical leukemia cases at reduced costs and staffing specifically we will i deploy a realworld dataset from the routine input of the mll ii train and evaluate our algorithm for transparent decision making on routine diagnostic blood smears iii quantify the gain in sensitivity specificity and speed by comparing leukoscreen with the currently used manual workflow at mll and iv jointly develop a commercialization strategy for the exploitation of resultsthis ai approach to support disease detection will save patients lives change the paradigm of cytologic workflows and create capacities in overburdened diagnostics
orthopaedic treatment with allogenic combined atmp in long bone fracture delayed union and nonunion orthoallounion

bone fracture with delay or failure to heal is a condition with huge health impact although only a small proportion of long bone fractures evolve to nonunion 5 it is a first magnitude problem due to the number of new annual fractures and increasing incidence of complex fractures with high risk of nonconsolidation need for repeated procedures and years of patient disability bone autografts autologous mesenchymal cells or other complex interventions are used in this setting the aim of this project is the development of a universal therapy for fractures with delay or failure to heal aiming to a simple and wide access to allogenic cell therapy combined with biomaterial in a broad number of patients rather than considering atmp only as a last solution in established nonunion fractures this project advocates that the indication should be moved to an earlier timepoint patients will be treated with the combined atmp as soon as the need for reoperation is identified due to delayed healing with or without an added infectious component to avoid longterm suffering for patients and their relatives and prevent progression to more severe nonunions with heavy personal social and economic costs this approach is aligned with the real needs of patients and better fits with the usual practice in the eu where reoperations are performed at 6 months or before in an attempt to accelerate bone healing and avoid complications the project will establish a master cell bank for a wide allogenic production with donors selection criteria of bone formation potential necessary preclinical and clinical information to support the eu approval of a specific combined atmp will be obtained open access to scientific and regulatory information will be available for other eu medical device companies and cell therapy producers so in addition to direct clinical benefit to patients and healthcare providers other developers of combined atmp products will get benefit
enabling environmental mycotechnologies

enabling environmental mycotechnologies eemeem aims at developing soil fungal based remediation solutions to a commercial scale indeed emerging fungalbased approaches have been proposed as attractive options for the biological treatment of polluted matrices such as soil sludge sediments and water such mycotechnological approaches also offer an exciting potential for the restoration of degraded ecosystems mycoremediation and mycorestoration as they have the potential to foster the adoption of low carbon sustainable solutions in many industrial fields such as agricultural biologicals biostimulants biopesticides etc mycomaterials production of enzymes for the industrial sector products for the agrifood industry the specific objectives of eem aresecuring novobioms core ip assets as one proprietary dynamic knowledge repository this will be achieved by establishing a tailored fungal database for environmental applicationssetting novobioms strategic roadmap for the protection diversification and scaling of all foreseen fungal applications
biomicauth center of excellence in metabolomics research

biacem aims to link biomicautbiacem aims to link biomicauth an interdisciplinary laboratory of the aristotle university thessaloniki with three world leading metabolomics research groups the bioinformatics team of imperial college london the metabolomicslipidomics research team fundacin universitaria san pablo ceu madrid and hmgu via the realization of the project strategic partnership and networking will be developed promoting the research status and capacity of biomic researchers and covering existing gaps in knowhow and technology long term aim of biomic is to lead develop new concepts analytical methods and ways to produce or analyze comprehensive datasets furthering the application of metabolomics in life science and biomarker discovery to reach this level existing pinch points should be addressed themes identified as strengths of the advanced partners and key areas of biomic improvement include development and organisation of lipidomics experimentation in lcms exploitation of advanced mass spectrometry acquisition and ion mobility spectrometry data metabolite identification effective mining and use of multiple data sets data management artificial intelligence tools for metabolomics data and for text mining natural language processing data fusion effective biochemical interpretation transfer of knowledge is organised as a series of training events webinars emeetings staff exchanges and collaborative research with the advanced partners emphasis is also put on training on research management and setting a research management unit in biomic three clinical biomarker discovery demonstration projects constitute the research element of biacem realization of the project will have major impact on biomic their collaborators and the greek metabolomics ecosystem as it will remedy weaknesses and provide new timely and necessary technological solutions for the first time to greek scientists promoting level or research and innovation
international political ecologies of land in southeast europe policymaking everyday experiences and alternative political imaginaries

ipelsee studies the transformations of land use and land ownership in south east europe see in processes of postsocialist transformation different stages and paths of eu integration and the restructuring of global capital flows to do so it approaches land as differently assembled humansoil relations as a policy object an everyday experience and a site of alternative political imaginaries it has two aims 1 to develop an international politicalecology framework capable of studying humansoil relations across multiple scales and 2 to use that framework to better understand transformations in rural and agricultural land use in bosnia and herzegovina croatia and serbia while political science and international relations have focused on issues of power sovereignty and territory they have habitually ignored the humansoil relations that make the land they talk about and the rural areas where those relations are grounded ipelsee is based in three case studies a disputed largescale investment in agricultural land in serbia and two projects that reimagine land use in line with alternative political ecological social and economic ideas a cooperative producing autochthonous grains in bih and an eu funded project for conservation and restoration of dry grasslands in croatia it uses welltrodden methods interviews participatory observation document analysis and innovative methodologies participatory mapping to investigate humansoil relations and their transformations beyond academic contributions to international political ecology within ir interpretive methods in ir and polsci and see area studies communication activities will focus on researched countries to counter the stigmatisation of rural areas and shed light on practices of land use and land ownership that are not only used traditionally but can also contribute to more sustainable and just land use in the future
advanced biodiversity monitoring for resultsbased and effective agricultural policy and transformation

unsustainable agricultural practices are major drivers affecting habitat and species diversity in agricultural landscapes of the eu however peatland grassland and species associated with agriculture are of most concern the ongoing negative impacts of unsustainable agricultural practices emphasize the need for a fully integrated approach between the eu 2030 biodiversity and farm to fork strategies supporting the ecs ambition of enhancing biodiversity of agricultural landscapes advanced systems are required to monitor biodiversity features and their changes over time and in space such biodiversity monitoring systems will support implementation of resultbased policies in the european agricultural landscapes the biomonitor4cap project will design advanced biodiversity monitoring systems mainly assessing diversity of targeted species and habitats to be tested calibrated and demonstrated in five european regions representing the major agroecological regions of the eu and one region in peru representing one of the global biodiversity hot spots the project will combine classical indicator systems that are part of the european monitoring framework eg farmland bird index with various indicator systems mostly recently developed and applied in form of standalone systems i new indicator species eg grasshopper ii genetic diversity edna iii onsite sensors eg wing beat frequency acoustic sounds iv functional diversity eg pollinators and iv various spatial measures supporting development and implementation of revised agricultural policies and ensuring rural development the project will involve among multiple stakeholder groups particularly farmers conservationists and service provides as the value andor marketability of public andor private goods delivered through maintained and enhanced biodiversity and related monitoring systems are hardly understood
the gene therapy coe at the center of portugal

the main goal of the present project is the creation of a gene therapy research innovation hub rooted in a center of excellence coe located in the centro center region of portugal the genet this coe will capitalize on the already existing rdi capacity in the field at the university of coimbra uc the regional and national pivot of the innovation potential and knowledge transfer in red biotechnology and act as an international enabler of scientific and business excellence in gene therapy innovation and manufacturinggene therapy is the latest revolution in the treatment of severe human diseases with the highest curative and economic potential in the health sector extraordinary results have already been achieved in the treatment of a few neurological ophthalmic hepatic oncological and hematological disorders with outstanding clinical and economic impacts uc notably its center for neuroscience and cell biology has proven scientific excellence in specific areas of the field and a matchless ecosystem to strive in this high addedvalue sector which encompasses the coimbra university hospitals and the biotechnology park biocant recognized as the epicenter of the biotech industry in portugalto achieve its goal the project will teamup with the university of sheffield home of the gene therapy innovation and manufacturing centre a uk pioneer hub dedicated to advancing the clinical development of new genetic treatments and the university of eastern finland which hosts the finish national virus vector laboratory with viral vector gmp production capacity and scaleup key to gene therapy development these two top european institutions are international references in the field at fundamental translational and innovation levelsgenet will thus become a beacon of excellent in gene therapy ri with enormous impact in the decrease of mortality and suffering while contributing to the economic recovery and growth of portugal and the eu