Dragon09/odtu_chatbot huggingface dataset:
holistic approach towards empowerment of the digitalization of the energy ecosystem through adoption of iot solutions

hedgeiot proposes a novel digital framework which aims to deploy iot assets at different levels of the energy system from behindthemeter up to the tso level to add intelligence to the edge and cloud layers through advanced aiml tools and to bridge the cloudedge continuum introducing federated applications governed by advanced computational orchestration solutions the hedgeiot framework will upgrade the reshosting capacity of the energy systems and will unleash a previously untapped flexibility potential it will increase the resilience of the grid create new market opportunities and promote advances in iot standardization by introducing and managing a plethora of diversified interoperable energy services over scalable and highly distributed data platforms and infrastructure the multidimensional framework of hedgeiot comprises the following pillars a the technology facilitator pillar will exploit the computational sharing by offloading applications on the grid edge towards providing a set aiml federated learning and swarm computing applications b the interoperability pillar which leverages on leadingedge interoperable architectures such as the data space architectures c the standardisation pillar will enable all involved platforms systems tools and actors to seamlessly communicate and exchange data in standardized formats using widely used standards such as saref etc d the digital energy ecosystem enabling pillar will ensure the creation of an ecosystem facilitating the increased integration of res and characterised by resilience liaisons with eu initiatives for iot and digitalisation will be established eg the aioti and the engagement of stakeholders will be ensured by addressing iot ethics and cultivating trust among endusers thus promoting inclusivity scalability and replicability studies will be performed and connections with innovators and smes will be established through the open call mechanism of the project
superconductingnitride by areaselective ald at low temperature

the field of computing saw a breakthrough when quantum supremacy was established and it was demonstrated that a classical computer will take 10000 years for a task that a quantum processor based on superconducting qubits took 200 seconds the future generation of computing hardware that can deliver high performance parallel computing include i high performance superconducting circuitsbased computing hardware and ii quantum processors based on superconducting qubits key components of these technologies like superconducting nanowire for singlephoton detectors snspds cryogenic interconnects and ground plane electronics use superconducting nitrides suns such as nbn tin and nbtin however despite the heavy reliance on suns optimal deposition processes to engineer these materials to meet the challenges of the technology are still lacking the desirable process should be able to engineer the features of conformality provide continuous pinhole free films with controlled thicknesses between 25 nm occur at low temperatures and in some applications provide selectivity to reduce the patterning overheadthis project addresses this gap in sun material engineering by generating scientific understanding that is pivotal to enabling the quantum processors in the future we intend to do so by investigating novel chemistries and sequences of atomic layer deposition ald coupled with surface functionalization in order to enable the fabrication of cmos industry compatible area selective ald at low temperature salt of the widely used suns of nbn tin and nbtin this project will increase the understanding of ald using reducing agents and inhibitors advance the science of area selective ald and enable higher fidelity qubits therefore this research contributes to advancing chemical science and caters to the critical needs of the superconducting digital electronics as well as quantum processor hardware since suns are ubiquitous to both technologies
enhance knowledge on comprehensive electrolysers technologies degradation through modeling testing and lifetime prevision toward industrial implementation

the electrolife project aims to be a booster to enable the use of green hydrogen technologies to support decarbonization of european global industry currently electrolysis technologies suffer from limitations in terms of cost efficiency stability scalability and recyclability this is mainly due to the lack of understanding and identification of electrolyzer degradation mechanisms and improvement of current cell performance electrolife aims to increase the efficiency performance of electrolyzers by reducing the use of critical materials and extending the useful life of these systems these goals will be achieved through test campaigns to identify multiple degradation mechanisms on multiple scales multiphysics simulations with superimposed degradation mechanisms prototyping of cells and stack components and construction of dedicated test benches the type of testing will be harmonized through dedicated protocols and test results will be processed and made available through dedicated online data centers in addition diagnostic and stack health models will be developed to reduce the degradation rate enabling the implementation of predictive control systems electrolife will demonstrate the implementation of durable stacks using relevant experimental methods through the production of highperformance technologies with minimal crm content enabling scalability and recyclability electrolife is expected to reduce the average cost of ownership of the electrolyzers by 40 for ael and pemel and by 70 for aemel and soel these achievements will enable utilization of the innovations developed by electrolife reaching 15 of european production capacity corresponding to about 3gwa iea 2022
tumor recurrence and therapeutic resistance exploring and exploiting the postradiotherapy brain microenvironment for therapeutic opportunities in malignant brain tumors

gliomas are the most common brain tumors and the highestgrade glioma glioblastoma gbm is arguably the most aggressive tumor type with no longterm survivors patients with gbm are treated with radiotherapy chemotherapy surgery and tumor treating fields despite initial response all tumors recur as incurable lesions there is an urgent need for novel therapeutic approaches for this patient group the majority of gbms recur within the treatment field receiving highdose radiotherapy during treatment of the primary tumor the recurrent tumor thus forms in an irradiated microenvironment despite the fact that it is the recurrent tumor that ultimately kills the patient and that the majority of new therapeutic agents for gbm are tested clinically in the recurrent setting the majority of experimental models and clinical materials for drug discovery are based on primary disease recent advances established a central role for the tumor microenvironment in determining the therapeutic response of gbm cells and our lab demonstrated that standard of care radiotherapy of the primary tumor can shape the microenvironment to generate tumorsupportive conditions in the recurrent tumor these findings suggest that there is untapped potential in targeting the irradiated microenvironment this proposal aims to explore and exploit the recurrent brain tumor microenvironment by i consolidating the contribution of the irradiated brain tumor microenvironment to gbm resistance by integrating spatial transcriptomics single cell rna sequencing and multiplexed immunohistochemistry from stateoftheart murine and human models of gbm treatment and recurrence and ii discovering and targeting novel therapeutic targets unique to the postradiotherapy brain tumor microenvironment by highthroughput phenotypic screening with the ultimate goal of exploiting reversible stromal radiation responses and leverage novel therapeutic opportunities unique to the irradiated brain
unraveling the dark matter of infectious diseases environmental and genetic factors tipping the balance towards ncds

while it is known that postcovid19condition pcc is caused by sarscov2 infection for most other immunerelated noncommunicable diseases irncds no such infectious disease id triggers have been identified yet many ids exist that could potentially cause irncds however these microbes have large genomes encoding many antigens possibly associated with irncds given that it is challenging to measure all these 100000s of structures in parallel they represent the dark matter of idimmune interactionsfurthermore exposure to an id alone typically does not trigger development of an irncd for example only a subset of patients infected with sarscov2 develop pcc so genetic and environmental aspects also affect the onset of irncds but the exact factors are unknown for most irncdshere we aim to 1 identify ids triggering irncds by screening for antibody responses against 600000 id antigens and 2 to disentangle environmental and genetic factors affecting the transition from ids to irncds we will combine novel multiomics approaches and technologies for personalized genotyping of hla and adaptive immune receptor genes to deeply profile 6000 patients of six irncds pcc multiple sclerosis mecfs rheumatoid arthritis lupus ibd to identify novel biomarkers and disease mechanismsthis project will represent the largest and most deeply profiled systematic study of multiple irncds with layered datasets allowing for comparative analyses yielding insights into shared mechanisms and potential differences in the role of ids between irncds building on associations identified from population scale and clinical cohorts we will demonstrate causality in gnotobiotic mouse models and leverage machine learning ml algorithms to predict disease progression and response to treatment the combination of novel assays with ml represents a broadly applicable pipeline that can be used for studying the interplay of any other ids irncds
digitisation of cultural heritage of minority communities for equity and renewed engagement

cultural heritage ch digitisation brought great opportunities to preserve maintain and promote it yet it also triggers challenges in terms of representation and content exhibition this becomes particularly pressing in the context of ch of minorities overall this reduces participation and inclusion of minorities hindering equitable representations of diverse values in digitisation leading to increased risks of misuse of digital ch digicher tackles these challenges by providing new understanding on key legal and policy socioeconomic and technological factors governing digitisation of minorities ch following the citizen science and cocreation approach digicher develops a novel scalable framework and methods to promote equitable diverse and inclusive practices verified via usercentric approaches through pilots with three minority groups in the eu the smi the jewish and the ladin people with a further exploitation in other minorities groups on these bases it develops recommendations for policy and decision makers as well as ch institutions and delivers methods for decision support to monitor the field of digital heritage with specific regards to its diversity longtermthe digicher interdisciplinary consortium will lead to several actions and outcomes that will increase minorities involvement in the digitisation and usage of their ch contributing to a more responsive and democratic cultural sector whose digital activities reflect the plurality of minorities worldviews in europe minority heritage will be represented in a way which respects minorities values ensuring better understanding and enhanced engagement with minority heritage collections by the general public and professional heritage users leading to more resilient european cultural institutions with a pluralistic offer that is appealing to a diverse future generation of audiences
a rosetta stone for robust observables of topological states from symmetry group theory

solidstate materials hosting topological insulating ti states have been intensely studied following predictions that their bulk and surface features may serve as robust platforms for spintronics quantum computing and magnetoelectric responses 3d topological crystalline insulator tci states protected by crystal symmetries have also been predicted and through firstprinciples dft calculations thousands of candidate tis and tcis have been identified including correlated chargedensitywave and magnetic variants though topological materials can readily be mathematically classified we still do not know the bulk experimental signatures and advantageous properties of most topological states limiting their practical applicability in chemistry materials science and quantum devices to unlock the immense promise of solidstate tis and tcis i propose to leverage the group theory of crystal symmetries to produce a rosetta stone to translate the mathematical topological classification into robust and intuitive experimental observables such as the spin and charge trapped by defects and new electromagnetic responses first we will devise theories of topological spin orbital valley and layerresolved bulk surface and crystal defect responses in 3d tcis and introduce numerical methods for their identification in real materials next we will for the first time construct a positionspace symmetrybased methodology for systematically enumerating and analyzing superconducting sc tcis which may host excitations advantageous to the storage and manipulation of quantum information we will introduce the fundamentally new notion of sc symmetry groups to characterize sc tcis by exploiting tension between their position and momentumspace descriptions this will uniquely allow us to sidestep specifying the mechanism or strength of the sc order for both lines of inquiry we will apply data mining and dft to identify and characterize material candidates
european partnership for personalised medicine

ep permed is a new european partnership dedicated to personalised medicine pm it supports pmrelated ri but also facilitates and accelerates all steps so that pm achievements successfully pass through the full value continuum to be implemented in sustainable health systems for the benefit of people and societies the partnership will foster demonstration projects and promote successes and lessons learned to demonstrate evidence of pm implementation ep permed activities cover overarching aspects like patient involvement exchange with medical societies infrastructures and international and regional collaboration the project portfolios of ep permed and era permed eranet cofund on pm and others are supported to become successful innovations in healthcare practice ep permed will be the global pmplatform for scientific and strategic dialogue and alignment resulting in public documents and publications accordingly it will inform the public patients healthcare providers or payers about the latest pm options and engage them the strategic research and innovation agenda for personalised medicine sria for pm 2023 developed by ep permed partners is the basis for the partnerships structure and a wide range of its activities all steps of the sria development were strongly support by numerous pmexperts stakeholders and the european commission ec thus the ep permed annual joint transnational calls jtcs and other funding and activities events and tools will be in line with the sria and outputs will feed into a sria update in the coming years the partnership builds on several developments initiatives and projects such as era permed icpermed and its supporting projects icpermed family funded by the ec in parallel it reaches out to the 1million genomes initiative other european partnerships in the health cluster and infrastructures like the european strategy forum on research infrastructures esfri
intranasal rapidacting vaccine for all seasonal and pandemic influenza viruses

researchers worldwide have been working to develop a universal flu vaccine but no breakthrough has yet been achieved fluniversal is not another costly universal flu project it is an opportunity to create a genuine universal flu vaccine that will set the standard for rapid efficient vaccine development and generate knowhow and tools to develop nextgeneration vaccines we plan to exploit our increased understanding of molecular mechanisms of influenza infection and immunity to develop a vaccine effective against all flu virus strains our innovation uses genetically modified flu strains administered intranasally in a primeboost regimen this approach rapidly induces interferon and broadly crossneutralising antibodies in the nasal passages and a systemic immune response directed to the conserved ha stalk proof of concept for universal protection was demonstrated in the ferret
innovative pulse and cerealbased food fermentations for human health and sustainable diets

food fermentation has been used for millennia but our knowledge on the impact of fermented foods on human health and the possible role of gut microbiota in it is limited microbial consortia and fermentation processes are hence not designed for optimal health outcomes at the same time fermentation technology represents a major opportunity to increase incorporation of plantbased proteins in diets the multiactor consortium healthferm brings together firstclass researchers food companies and dissemination partners to enable the transition from traditional to sustainable grainbased fermented foods and diets that deliver health benefits to consumers by designthis will be achieved by 1 disentangling the interaction between food fermentation microbiomes grainbased foods and the human gut microbiome and health and 2 using microbial resources and fermentation technology to develop healthy pulse and cerealbased food and diets that cater to the desires and needs of eu citizens drawing from a community science approach healthferm will identify microorganisms and metabolic pathways that may result in desired nutritional and health effects the impact of microbial fermentation on raw materials will be examined at the molecular level fermentation technology will be used in the production of grainbased liquid and semisolid foods the impact of these foods on human health and the gut microbiome will be assessed in a number of intervention trials consumer acceptance of fermented foods their technologies and their role in the transition towards a more sustainable healthy diet will be studied in different social contexts finally extensive ecosystem building and training activities will contribute to healthferms strong participatory approachoutcomes will allow increased use of grainbased materials in foods contributing to an environmentfriendly food system and a strong eu food industry thus aligning with the eu green deal priorities and un sdgs
compound extremes attribution of climate change towards an operational service

climate change increases the frequency and severity of extreme weather events such as storms heatwaves and droughts such events can have devastating societal impacts and it is becoming increasingly clear that the most impactful disasters are often the result of a complex interplay of multiple physical and societal drivers climate attribution which examines the causal links between extreme events natural variability and anthropogenic climate change can help to unravel this complexity and thereby promote societal preparedness and awareness for climate change impacts the compass project aims to develop a harmonised yet flexible methodological framework for climate and impact attribution of various hazard types compass will go beyond the current frameworks by bridging the gap from the attribution of singledriver extremes to the attribution of more complex extremes that is compound sequences and cascading hazard events and enabling a shift from a hazardcentred analysis to an impactcentred perspective main novelties include eventbased hazard and impact modelling using a multiscale approach the use of weather type analysis for better understanding the physical drivers that give rise compound extremes and the use of contextualized storylines to communicate attribution results the framework will be validated and applied to a set of use cases that cover historical extremes for various hazard types and impact context as well as extreme events happening during the project compass will lay the scientific foundation for the operational deployment as part of the copernicus climate change services the project will create a modular and scalable framework for onthe fly analysis and thus transferable to other extremes and regions to promote uptake of the projects results data methods and tools will be made openly available a webbased demonstrator will showcase the results of the use cases and clear guideline for attribution will be developed
greek heritage in european culture and identity

the heritage of ancient greece is commonly acclaimed as a pillar of common european culture and identity the complex historical processes of cultural reception and appropriation that shaped this notion are however still hardly understood the project greek heritage in european culture and identity greci explores a key phase in this process the reception and appropriation of ancient greek culture in early modern europe 15th17th century from the socalled rediscovery of greek language and literature to their full incorporation in the european cultural landscape it aims at creating the interdisciplinary and international framework required to address this complex historical subject and its implications for presentday ideas of european identity to achieve this three twinning partners from cyprus university of cyprus norway university of oslo and france university of franchecomt join forces in a unique combination of scholarly strengths and academic potential together they unite several vibrant disciplines that are pivotal to understanding early modern hellenism but are seldom joined to shed light on the subject the history of the book and material heritage studies language and literature studies and intellectual history reformation studies with a shared emphasis on the reception and appropriation of greek heritage in early modern europe by a carefully designed research and excellence programme greci will both cement ucys international profile in the field of early modern history and make ucy together with its partners leading research milieus in the emerging but still fragmented field of early modern hellenism