Dragon09/odtu_chatbot huggingface dataset:
sustainable nanoparticles enabled antimicrobial surface coatings

the catastrophic ongoing pandemic has attracted our attention towards the spread of harmful pathogens facilitated by high traffic surfaces highlighting the importance and urgency of an economically and environmentally sustainable solution for antimicrobial surface as a potential strategy to mitigate the spread of disease outbreaks nanoparticle np filled coatings with recognised effectiveness against bacteria viruses and fungi are valuable candidates for developing antimicrobial surface and minimising the surface adhesion of pathogens however due to the many technical challenges including difficulty to develop nanocoatings with a longterm antimicrobial capability durability under real conditions and safety assurance their application at industrial level is still limited the supreme consortium will develop a platform of efficient and multifunctional antimicrobial nanocoatings building upon bespoke tio2 nanoparticles that have demonstrated an exceptional antimicrobial ability at lab scale trl3 two sustainable routes 1 customised coreshell and advanced functional nanoparticles and 2 hybrid fibrenanoparticles using sustainable biobased cellulose materials and nanoparticles will be pursued bearing in mind the specific requirements of individual applications the supreme consortium will coordinate the antimicrobial testings to its effectiveness against a wide range of pathogens the production of the supreme coating will follow a sustainablebydesign approach that considers both toxicity and environmental impact from outset to guarantee both market acceptance and sustainability of the overall process whilst having a robust safety assurance in place for human health the scalingup production of these sustainable materials and their validation according to the industrial requirements will enable to reach the trl6 by the end of the project
exploiting cellular metabolism to develop the next generation of mtor inhibitors

the mtor mammalianmechanistic target of rapamycin kinase as part of the mtorc1 and mtorc2 protein complexes is the master controller of cellular and organismal physiology dysregulation of mtorc1 activity is tightly linked to human disease and ageing consequently mtor inhibitors have been tested in various clinical settings however with little success and limited applicability so far mainly due to low efficacy or adverse effects thus highlighting the need for more potent and more specific compounds for instance the phosphorylation of most mtorc1 targets is resistant to rapamycin and its analogs rapalogs furthermore catalytic mtor inhibitors demonstrate increased toxicity and cause unwanted metabolic effects mainly because they also block mtorc2 activity we have recently identified malonylcoa a metabolic intermediate of fatty acid biosynthesis as a novel specific mtorc1 inhibitor in cells that shows improved characteristics over existing compounds as it blocks phosphorylation of all mtorc1 targets without affecting the activity of mtorc2 or other related kinases using our biochemical structural and computational data as the basis for targeted compound development we aim to develop synthetic malonylcoa derivatives as a new class of mtorc1 inhibitors with improved specificity and effectiveness because of the wellestablished role of mtorc1 in ageing and disease these inhibitors are expected to be of profound scientific clinical and commercial interest
plasticity of perception in real and virtual spaces

space is fundamental to physical and perceptual reality but physical and perceptual space are not the same perceptual space is created by the brain and plastically formed by the sensorimotor interactions of our body with physical reality in the digital future these two spaces are joined by novel spaces experienced in virtual vr and extended xr reality as these new technologies massively expand in work pleasure and social interaction the first aim of places is to understand how sensorimotor interactions in virtual environments shape perceptual space and how this interacts with virtual vs and real rs space secondly deep and improved knowledge of perceptual mechanisms is essential for the future development of vr as a key digital technology for europe to work for the people vr and xr need to be effective comfortable transparent and fair these aims can only be reached by understanding and accounting for perception in a humancentric manner based on these premises the highly interdisciplinary consortium of places pursues five key objectives to 1 use cuttingedge vr technology to advance scientific knowledge of the mechanisms of sensorimotor perception and plasticity 2 use our understanding about spatial perception gaze control and sensorimotor plasticity to advance vr technology and enhance vr applicability 3 predict action intentions of users in vr and employ these predictions in advanced user interfaces 4 understand how longterm usage of vr interacts with perceptual and sensorimotor states in real space and in virtual space and 5 translate research findings into applied fields in vision aids and social telepresence reaching these objectives will put the eu on the map as a leader in perception research and its application in vr places aims for new frontiers in perception science and its applications and for a significant impact on the people of the eu
strengthening rural livelihoods and resilience to climate change in africa innovative agroforestry integrating people trees crops and livestock

the overall objective of galileo is to rely on genuine multiactor approaches maa to codevelop contextspecific peoplecentered agroforestry innovations in representative agropastoral agroforestry and agrosilvopastoral systems from subsaharan africa ssa the aim is to promote agroforestry as leverage to significantly improve agricultural household and climate change adaptation and mitigation performances and to enhance biodiversity in ssa we build upon 8 agroforestry living labs lls local scale and actors 4 national and 1 regional innovation platforms ips set up across 4 au ssa countries our lls are set in semiarid zones of senegal and kenya and normally humid but droughtprone zones of ghana and cameroon thus comparing and covering a large range of ssa conditions through mma we coconstruct potentially adoptable scenarios exante with innovator target and control actors in our lls then implement assess and compare performances in their pilot plots during the whole project we use field observations also to calibrate process models able to simulate under future cc scenarios after full multicriteria and tradeoff analysis we finally coselect the most effective scenarios expost we thus rely on transdisciplinary research providing qualitative and quantitative data on the biophysical socioeconomic and environmental performances such adoptable agroforestry innovations will also enable farmerspastoralists and stakeholders to diversify their incomes from new agroforestry value chains of which 2 are galileooriginal they will also benefit from carbon farming and payment for ecosystem services opportunities through our ips we also engage in solid maa collaborations and policy dialogues to first identify bottlenecks and second elaborate guidelines and policy recommendations helping towards strengthening their local innovation ecosystems under a favorable institutional and policy framework
faithbased refugee relief in europe connecting the empirical and the ethical

fabric develops a new ethics of migration by understanding and utilizing the moral insights and the moral ideas that faithbased refugee relief organizations develop and deploy in practice for the crossdisciplinary debate about the ethics of forced migration in europe globally forced migration is one of the most pressing and one of the most pervasive challenges europe has been pushed to a social and political breaking point over migration the fallout is a death toll that makes the border around the continent the deadliest border in the world faithbased organizations fbos have been at the forefront of this challenge preventing the collapse of the infrastructures of care combatting racist discourse and religious discrimination yet there is very little knowledge about the refugee relief of these fbos so their significance for the ethics of migration has been neither analyzed nor assessed fabric addresses this lack by conducting a comprehensive and comparative empirical exploration of fbos at an unprecedented scale covering activities by fbos from all three abrahamic faiths in mono and multireligious settings across the continent countering the lack of interaction between empirical and evaluative approaches so characteristic of the study of forced migration fabric presents a pragmatist understanding of ethics to enquire into the conditions constraints and consequences of practicing justice it offers a concrete account of faithbased refugee relief in order to formulate a new concept of mobility justice that considers crossconnections between social racial and climate justice on regional national and global scales thus fabric formulates a new ethics of migration from the bottom up putting the debate about the ethics of migration on an empirically more perceptive and ethically more productive footing that advances knowledge production on forced migration across the academy
competition and regulation in the digital economy

the digital economy is of growing importance for society but its development challenges the traditional approaches to competition policy and regulation based on a benchmark of perfect competition that regulatory authorities aim at approaching in the various relevant markets economies of scale and scope are more the rule than the exception network effects and multisidedness are pervasive information and data are shaping industries the boundaries of the markets are becoming blurred and industry dynamics are on a new scale these features make the perfect competition benchmark and the focus on individual markets less relevant calling for a new conceptual framework for the analysis of competition in the digital economy the proposed research aims at breaking new ground on four related fronts first competition in the digital economy is increasingly between ecosystems involving multiple products and often multiple actors second platforms compete for consumer attention raising questions about consumer behaviour and platforms ability to influence it third the digital revolution has drastically affected the way firms compete and cooperate along the vertical chains of production and distribution finally the role of data raises questions not only about the interplay between business strategy and consumer privacy but also about how the quest for data can shape entry and competition in product markets on each theme several avenues are proposed to enhance our understanding of how competition works in the digital era the insights will shed light on desirable changes for competition policy and regulation interpreted in a broad sense including policies that affect the functioning of digital markets such as consumer or privacy protection policies
building excellence in systems immunology and healthy aging research

the demographic landscape of europe is changing rapidly with an increasing number of old individuals the increase in elderly people poses significant challenges for europe in multiple spheres notably in healthcare and its associated costs as well as in overall wellbeing and cohesion of the european population healthy aging is therefore a crucial research and policy theme and a healthy immune system is essential for thisbuilding upon the expertise in the molecular and cellular aspects of immune system function excellent infrastructure and access to unique datasets of the estonian biobank the university of tartu utartu aims to become a world leader in research on agerelated decline in immune function to address the societal challenge of agerelated diseases and immunosenescence to achieve this utartu will partner with two excellent institutions in the fields of systems immunology and aging institut pasteur france and the university of copenhagen denmark we will implement a wide range of activities to transfer to utartu knowledge and skills in 1 methodologies for studying molecular mechanisms in aging 2 cuttingedge techniques for immunomonitoring 3 big data and machine learning techniques for immunoprofiling and 4 conducting healthy cohort and longitudinal studies utartu will also receive guidance on interdisciplinarity aspects of healthy aging research as well as on research management and commercialization partners will implement a pilot research project and prepare a joint research strategy to ensure longterm and mutually beneficial collaboration
deeplearning 20 metalearning qualitatively new components

deep learning has revolutionized many fields such as computer vision speech recognition natural language processing and reinforcement learning this success is based on replacing domainspecific handcrafted features with features that are learned for the particular task at hand the logical step to take deep learning to the next level is to also metalearn other handcrafted elements of the deep learning pipeline we therefore propose to develop metalevel learning methods for the creation of novel customized deep learning pipelines by means of1 hierarchical neural architecture searchfor learning qualitatively new architectures and architectural building blocks from scratch2 learning of optimizers and hyperparameter adaptation policies that adapt totheir context in order to converge faster and more robustly 3 learning the data to train on to remove the need for large sets of labelled data and 4 bootstrapping from prior design efforts to increase efficiency and make an integrative design of architectures optimizers hyperparameter adaptation policies and pretraining tasks feasible in practicethese advances will allow the next generation of deep learning pipelines to achieve higher accuracy lower training time and improved easeofuse democratization of deeplearning they will also allow a customization to particular design contexts including additional objectives next to accuracy such as robustness memory requirements energy consumption latency interpretability training cost uncertainty estimation and algorithmic fairness in order to facilitate trustworthy ai in order to demonstrate the effectiveness of these methods we plan to develop5 new stateoftheart customized deep learning pipelines for various applications including eeg decoding rna folding and improving the reinforcement learning pipeline and deep learning on tabular data
damabiox breaking the link between obesityrelated inflammation and oxidative stress by bioavailable compounds from apple pomace delivered in novel dairy beverages

overweight and obesity are risk factors for cardiometabolic diseases that can be partially prevented by adopting healthier lifestyles and eating habits such as increased fibre intake and other bioactive compounds such as phenolics however in the european union the proportion of overweight adults varies from 37 to 73 averaging 53 damabiox uses apple pomace ap to recover purify and encapsulate phenolic compounds apf and fibres to unveil the mechanisms of antioxidant and antiinflammatory properties of the bioavailable fraction in 3t3l1 adipocytes challenged with supraphysiological concentrations of palmitic acid to simulate obesity damabiox implements the use of an innovative humanised threedimensional coculture intestinal barrier model consisting of human enterocytes caco2 and human fibroblasts ccd18co to recapitulate human intestinal absorption the use and reuse of ap also target sustainable food production by harnessing agroindustrial side streams representing a tangible solution to produce functional foods damabiox addresses this aim across four work packages contributing to the environment agroindustrys circularity and public health damabiox brings together crosssectoral expertise strengthens the european capacity for healthier and sustainable innovations and generates new possibilities for food export the prestigious fellowship will provide the experienced researcher pf with the first step in a new research field that will act as a platform to kickstart the future international academic career the university of limerick is the place of renowned subject experts and exposure to international collaborators will provide the pf with a unique opportunity to grow as an independent researcher
inter materials and structures mechanoperception for self learning

forests insect swarms bones during remodeling are striking examples of biological systems whose elements possess the ability to sense and exchange signals these signals are exploited to adapt to evolving environmental conditions and to learn how to improve performance in some cases without a centralized controlcan materials and structures be enabled with the same capabilities how can we build devices that exchange information on a mechanistic base and exploit these to learn how to optimally react to external stimuli to what extent can materials and structures be endowed with active inference processes which mimic brain activitiesfinding answers to these questions is the challenge of immense with the overarching aim to create materials and structures able to sense exchange signals interpret and compare them thus achieving selflearning and selfadaptation this will be a major step toward the design of sentient materials and structuressolid and structural mechanics solidfluid interaction smart architected metamaterials coupled with multiphysics phenomena at micro and macro scales will be combined to implement sensing and signal control abilities on mechanistic basescomplex dynamic responses of oscillator arrays coupled with physical in materia computing replicating classification and learning processes will be innovative tools designed to implement learning and reacting abilitiesexperiments will be performed at micro and meso scales on ad hoc designed proof of principles prototypes to obtain evidence of sentient materials and structuresimmense will set the stage for a new class of materials and structures implemented with local decentralized sensing monitoring and reacting abilities and will open to a variety of new applications including local selfhealing of construction materials and biomedical prosthesis new monitoring and control of industrial appliances advanced unmanned vehicles and satellites
subduing selfdischarge of allsolidstate supercapacitors by a novel hybrid solid polymer electrolyte with layered inorganic nanofiller

the challenge taken worldwide in achieving a global climateneutral society fasten the transition from fossil fuel to renewable energy and increasing the demand for energy storage systems ess due to the intermittency of renewable energy sources supercapacitors sc especially hybrid supercapacitors are a promising technology for powering hybrids electric cars or microgrids owing to many exciting advantages over batteries concerning specific power and cycle life however some research challenges such as high selfdischarge high production cost and safety concerns impede market uptake so the development of efficient costeffective sc technology with extremely low selfdischarge high energy and power density is significant the saspe aims at developing an all solidstate supercapacitor and build a novel strategy to reduce its selfdischarge by applying modified solid polymer electrolyte with layered inorganic materials notably saspe will introduce a novel hybrid solid polymer electrolyte spe with high ionic conductivity that can reduce the selfdischarge of scs which will be prepared by a simple environmentally benign and costeffective method the saspe will guarantee scs safe operation by using modified spe with high mechanical strength saspe also offers 2d hybrid binderfree electrodes with promising electrochemical performance such as specific capacitance energy density and power density the project will connect the physical properties of inorganic materials with their electrochemical properties by using a nanofillermatrix synthesis approach and indepth physicochemical and electrochemical characterization techniques saspe will bring novel hybrid spe along with high capacitance electrode materials and will make a solution for problems faced in current sc technology the project will play a vital role in the electric vehicle industry by providing essential research progress in sc technology which will help attain a green environment
evolution of embryonic development across the preocialaltricial spectrum in birds

the project proposes to make use of modern molecular microscopic and computational tools to analyze the embryonic development of several species of birds and compare how major differences in embryonic mode and tempo develop and what consequences they have in the morphological diversification of avian clades i will collect embryonic series of species of several bird families that also represent independent evolutionary transitions in developmental mode and generate a large dataset of embryonic anatomical data to dissect how avian evolutionary patterns relate to developmental mode and tempo combining tools of comparative anatomy developmental biology geometric morphometrics and phylogenetic inference integrating the study of embryonic development with macroevolutionary analysesmany recent macroevolutionary studies have highlighted the need for the use of embryonic information yet these kind of datasets are mostly inexistent classical developmental biology has made use of selected species as models representing sometimes groups of thousands of species as has been the case of gallus gallus for birds only a few other avian species have been systematically studied and these represent an uneven coverage of the diversity of avian anatomies ecologies and life histories the project seeks to collect detailed embryonic information of several previously unstudied avian species and study them in the context of a series of major evolutionary transformations in order to bridge the existing gap between developmental biology with macroevolutionary studies the project will serve as a proof of concept for expanding this kind of newofitskind framework and will provide large amounts of information that have been classicaly associated with distinct field of biological sciences merging them into one interdisciplinary approach for studying the relationship between development and evolution