Dragon09/odtu_chatbot huggingface dataset:
transforming africas urban food environments through strengthening linkages between food systems stakeholders in cities across europe and the continent

afrifoodlinks afrifoodlinks aims to improve food and nutrition security while delivering positive outcomes for climate and the environment and building social and ecological resilience in 65 cities 15 african and 5 european implementation cities and 40 network cities cities by1 applying an urban food systems lens to promote shifts to healthy sustainable diets2 transforming urban food environments through realworld sociotechnical experiments3 promoting inclusive multiactor governance to empower public officials small businesses andcommunities with ownership and agency to shape their food systems and4 accelerating innovative women and youthled agrifood businesses to support local value addition andinclusive economic participationafrifoodlinks invests in direct food system change in 5 african hub cities and invites 10 african and 5 european sharing cities to join the hub cities on a mutuallearning journey to share their innovative food systems and to codesign specific pilot projects for implementation in each sharing city researchers posted within each of the 20 local governments will support the city to articulate its identified food system challenges and own authentic approach to improving access to healthy nutritious food with a particular attention to vulnerable groups and reducing food related environmental impacts through food systems intervention in this way these implementation cities become flagships beacons of inspiration for urban food systems transitions across the continent to inspire and share with over 40 network cities who are invited to adopt and adapt
cultuurcampus a sustainable hub of arts research learning and community as catalyst

cultuurcampus pilots a new approach to city making through education research policy and culture at the heart of rotterdam south an area which is exemplary of the complex challenges and diverse potential of europes most disadvantaged urban areas in our approach we facilitate the coming together of different types of knowledge theoretical practical from the arts and sciences with the lived experiences of citizens we do so in three waysfirst by cocreating a vibrant site of encounter dialogue and shared learning the cultuurcampus will be housed in a historical building the refurbishment of which unites a sustainable redesign vision of students of architecture and built environment with the wishes and needs of local stakeholders in a part of town where education and cultural institutions are scarce this will be a hub for students residents social enterprise startups lecturers and researchers a place for learning studying community art and culturesecond we will facilitate empowering the codesign of impactoriented learning curricula that can make the area more sustainable inclusive and enriching from sustainable crafts and repair workshops open to all to lifelong learning formats and master level courses we will test innovative didactic approaches geared towards activating and inspiring citizens students and lecturers in shaping a better future for rotterdam souththird we will ground our approach in participatory research and citizen science that empowers residents to take part in the processes that shape their city and delivers a sound understanding of the area its challenges and opportunitiesevaluating our experience we will identify the most effective strategies for delivering territorial transformations that build on situated knowledge of an area and where the vision is shaped and implemented through multistakeholder and multilevel collaborations
understanding sixth extinction as a hermeneutical challenge

hermex6 aims to elucidate the role of interpretative processes in our dealing with the global reduction of biodiversity commonly referred to as sixth extinction the contention is that in this case the difficulty to attribute value to scientifically attested facts is a problem of interpretation we lack qualitative frames to elaborate the extinction event and the knowledge that describes it the project intends to define analyse and address this set of issues with regard to contemporary european societies after testing the initial hypothesis the research project will formulate an innovative and interdisciplinary approach to the epistemic status of sixth extinction hermex6 addresses a european top priority with reference to the eu 20230 biodiversity strategy and aims to fill a major gap in environmental humanities it is therefore particularly timely the whole project is tailored to the scientific profile of the candidate and to the characteristics of the host institution the pompeu fabra university upf the project is planned to provide the candidate with an increased set of notions and skills and to sensibly boost the candidates career perspectives upf is an internationally renowned environment with several groups and initiatives addressing complex ecological problems in a transdisciplinary perspective the indicated supervisor professor santiago zabala is a leading expert in hermeneutics and philosophy of environmental emergencies in its more farranging implications hermex6 aspires to improve science communication and the uptake of scientific results raise collective awareness inform more effective conservation programmes and generate added value in the field of policy guidance and advisory
twodimensional acquisition for topdown native mass spectrometry of noncovalent protein complexes

native mass spectrometry ms is a powerful structural biology tool to study protein complexes their dynamics assembly and function in its socalled topdown approach it aims to link specific proteoforms to higher assemblies such as noncovalent complexes in which they function naturally andor in a disease the proposed project will leverage the power and versatility offered by stateoftheart fourier transform ion cyclotron resonance fticr mass spectrometry coupled to ultraviolet and infrared laser ion activation techniques to advance native topdown ms of large protein and protein nucleic acid complexes studying a range of protein complexes up to small viral capsids the project will push the boundaries of fticr ms in the analysis of highmass protein complex samples utilizing both standard commercially available protein complexes for method setup and benchmarking as well as biologicallyrelevant foxo tead and nucleosome protein dna complexes from the host laboratory advanced laser and electroninduced dissociation and fragmentation techniques and their combinations will be tested to obtain the best possible information on multiple levels of the complexes structure finally the hitherto untried combination of native ms of noncovalent protein complexes with twodimensional ms acquisition schemes will be explored to probe all species in a heterogeneous mixture at the same time linking the obtained sequential information on proteoforms to their complex and subcomplex stoichiometry this approach will help increase the utility of native ms as a powerful technique for the study of proteoforms and protein assemblies applicable to a broad range of biologically medically relevant samples promoting and reinforcing the position of native ms in the modern integrative structural biology portfolio as a technique providing information complementary to and difficult to access by classical highresolution approaches
characterization of protective antipneumococcal b cell immunity after immunization

pneumococcal pneumonia is one of the leading causes of death in children and the elderly worldwide pneumococcal vaccines have significantly reduced global incidence of pneumococcal disease however current vaccines show varying efficacy among covered serotypes leading to insufficient level of protection for complete herd immunity memory b cells bmem are responsible for highaffinity and longlasting humeral immunity and serotypespecific bmem are associated with increased protection against pneumococcal colonization despite their critical role to date information on immunizationelicited cellular responses is limited here i propose to characterize pneumococcal serotypespecific b cells for 25 cellular markers transcriptome and bcr sequence and link this phenotypic profile with functionality by analyzing recombinantly expressed antibodies these analysis will involve the integration of 33colour spectral flow cytometry 10x next generation rna and bcr sequencing b cell cloning generation of recombinant monoclonal antibodies and functional analysis by antibody avidity and opsonophagocytic capacity via computational science using a datadriven and highdimensional approach i aim to identify the phenotypes of protective serotypespecific b cell immunity by analyzing individuals of different ages children and adults geographic location malawi and europe and immunization route vaccination and colonization this information will shed light on cellular differences of nonefficient vaccine responses and may aid in development of improved vaccines additionally the proposed activities and training by experts will be critical for my career development to become an independent researcher in the field of clinical immunology and vaccinology
cosmology employing machine learning techniques and advanced statistics

some of the biggest open problems in modern cosmology are the nature of the cosmic dark sector the discrepancy between the theoretically predicted versus the observed value of the cosmological constant and the growing cosmological discordances and tensions between different observational probes notably the hubble constant which describes how fast the universe is expanding when measured locally has an enormous statistical disagreement with that inferred from the early cosmic microwave background data these inconsistencies in turn necessitate the formulation of new physics beyond the standard cosmological model current and ongoing observations together with upcoming surveys will produce large volumes of data whose accumulation and processing will require an upgradation and increase in the sophistication of our statistical tools before applying them to specific problems thus we propose to build a deep learning architecture using advanced statistics in machine learning algorithms like neural networks to be integrated into cosmological community codes for emulated parameter inference this will help us to select in a modelindependent way generic features of some cosmological theories that satisfy all observations utilising the power of deep learning will be an ideal space to investigate new physics in the observational sector and discriminate between models that are degenerate in terms of current observational approaches fostering the development of datadriven science as a valuable companion to the modeldriven paradigm the fellowship will contribute to the researchers career development by acquiring advanced skills in machine learning approaches using bayesian statistics and developing skills within the cosmological community through a series of events designed to disseminate his results to the broader public the project will also serve to consolidate and extend the researchers network of professional contacts within europe and beyond
uncovering the molecular effects of the tubulin code and their impact on organismwide functions

microtubules mt are core components of the eukaryotic cytoskeleton with essential roles in cell division cell shape intracellular transport and motility despite their functional divergence mts have highly conserved structures made from almost identical molecular building blocks tubulin proteins a variety of posttranslational modifications ptms diversifies these building blocks which is thought to control most of the properties and functions of the mt cytoskeleton a concept referred to as the tubulin codewhile they appear to have subtle effects at the molecular level tubulin ptms are essential for maintaining cellular functions of mts over large spatial and temporal scales yet a comprehensive knowledge of the principles of the tubulin code connecting its functions across the molecular cellular and organismal levels is almost entirely lackingour project aims to obtain a novel molecular and mechanistic understanding of how tubulin ptms control longterm cellular function and homeostasis our unique approach bridges all relevant scales of biology and relies on a synergy between our powerful experimental models and expertise in biochemistry structural biology singlemolecule assays systemsbiophysics cell biology and physiologyspecifically we will 1 determine how different tubulin ptms affect biophysical and structural properties of mts and their interactions with associated proteins 2 define the impact of tubulin ptms on overall mt cytoskeleton behaviour and the resulting physiological implications in neurons 3 combine zebrafish and mouse models and develop a novel fish model for lifelong invivo imaging to determine how the tubulin ptms control lifelong mtbased functionsour work will define the importance of tubulin ptms by revealing their critical molecular functions over the lifetime of an organism the project has the potential to substantially change our perception of the cytoskeletons role in homeostasis and disease
multiomics based risk stratification of atherosclerotic cardiovascular disease

atherosclerotic cardiovascular disease ascvd is the leading cause of mortality worldwide aside from asymptomatic manifestations the first sign of clinically significant ascvd is often a severe clinical event such as stroke or myocardial infarction mi thus identifying individuals at high risk is crucial in preventing the fatal consequences of ascvd current risk prediction models based on traditional risk factors such as score2 have limitations since they do not encompass all mechanisms and intermediary phenotypes leading to ascvd particularly current risk models fail to consider the disturbance of gene regulatory networks grns caused by genetic risk factors and diverse longitudinal exposures accumulating during a persons lifetimefurthermore the current models predict the combined risk of cad pad and ischemic stroke despite mounting evidence of the heterogeneity of the underlying disease mechanisms to capture the missing aspects of current ascvd risk scores miracle project brings together unique data resources and expertise to provide novel multiomics based prediction models of ascvd we aim to 1 integrate the globally largest cad pad and stroke gwas information to identify genetic loci that differ between or are shared by these diseases and their subtypes 2 identify sexspecific subtypes of ascvd patients using transcriptomic phenotyping of plaques and circulating biomarkers 3 generate functionally informed polygenic risk scores by combining experimental finemapping and gene prioritization approaches with integrative grn and deep learning modelling 4 derive novel risk prediction models incorporating polygenic risk and circulating biomarkers providing a new gold standard for prediction models to accurately risk stratify stroke and mi represents a technological breakthrough allowing for earlier diagnoses and treatments of ascvd
smart source leveraging advanced multimode fiber and machine learning towards metrology applications

complex nonlinear optical processes have been increasingly used for the smart photonic system to meet demands of advanced light source development for numerous applications current flagship techniques are still restricted lacking flexibility of the light excitation in terms of controlled spatiotemporal properties for instance available laser sources have only a few degrees of freedom for versatile pulse shaping and tunable wavelength emission due to narrow bandwidth of a laser gain medium conversely a wide range of applications benefits from broadband light sources with ondemand characteristics in the spectral temporal and spatial domains however available broadband sources are restricted by low output power density and limited reconfigurability therefore versatile efficient and practical light sources are necessary to motivate development of paramount applications including microscopy and metrology techniquesin this context the together project aims to develop an ondemand structured broadband highpower light source relying on the advantages of complex nonlinear dynamics in multimode fibers along with machine learning approaches to efficiently harness such multidimensional complexity in particular rich landscapes of nonlinear dynamics in multimode fibers will be leveraged for onthefly control of nonlinear propagation in parallel machine learning based on artificial neural networks will be employed to speedup typically timeconsuming simulations and optimize the process of supercontinuum generation in multimode fibers specifically we aim to optimize broadband sources in terms of power spectral intensity and spatial shapes the developed sources will be used to enhance the selectivity and signal of multiphoton microscopy via nearinfrared excitation while the extension of supercontinuum generation into the midinfrared range will also be investigated via nonsilica multimode fibers towards applications in molecular spectroscopy
race era chair initiative for establishing a research and innovation program of excellence on ageing and longevity at uoc

the university of crete uoc starting from humble beginnings has evolved into a globally recognized institution however in competitive fields such as ageing research uoc faces substantial challenges including disparities between regional and european approaches limited training programs insufficient access to skilled personnel and budgetary constraints that impede sustainable research and innovation excellence onsite to address these pressing needs uoc aims to recruit and fully integrate a distinguished era chair with worldrenowned expertise in science and management related to ageing research the era chair holder will establish the interdisciplinary research program race as a unit of excellence dedicated to maximizing uocs competencies capacities and expertise in ageing research the race team will leverage uocs stateoftheart infrastructure human capital and expertise to address a major research topic with significant healthrelated and socioeconomic impact building upon a wellstructured multidisciplinary research program the proposed era chair initiative seeks to recruit and fully integrate the era chair holder and the race team enhance uocs research capacity in ageing research strengthen human capital through training in both research and soft skills competencies increase competitive funding and counteract brain drain for sustained development additionally the initiative aims to foster innovation at uoc enhance the management and administrative skills of the institution leverage existing eufunded infrastructures and elevate the reputation of uoc through a comprehensive range of dissemination and outreach activities targeting the academic private and public sectors overall race presents a credible path to fundamental structural changes highquality research and impactful innovation that will transform uoc into an operational environment characterized by dedication perseverance and a commitment to excellence
protist pathobiomeinvertebrate interactions a multiapproach to understand marine diseases of commercial bivalves

marine disease outbreaks can devastate populations alter community structure and affect ecosystem health which results in biodiversity loses and economic impacts on ecosystem services bivalves which mediate ecosystem processes and functions and provide ecosystem services eg food harbour a wide variety of protists in their microbiome including parasites and pathogens protist species produce important economic losses on the worlds leading shellfish industries due to parasitic disease outbreaks in bivalve hosts and the transmission of pathogens affecting human health although the economic implications of these outbreaks in shellfish aquaculture are significant very little is known regarding their biology and ecology in this context propathin project is designed to advance our knowledge on marine and foodborne diseases caused by microbial eukaryotes protists associated to commercial bivalves through the multidisciplinary study of protistbivalve interactions at molecular cellular and community level i will employ recently developed molecular metabarcoding and omic techniques singlecell genomics and transcriptomics coupled with traditional cell biology methods for diagnose of infectious organisms in multicellular hosts i will assess the diversity composition and dynamics of oysters and mussels pathobiome in the ebro delta aquaculture setting during a year cycle environmental parameters will be used to assess the dynamics of such hazardous protists related to seasonal changes further we will sequence the genome and transcriptome of a protist parasite including different lifecycle stages from which very little information exists revealing the genes involved in the infection of bivalve hosts overall propathin will help us disentangle the nature and dynamics of such hostparasite relationships crucial to prevent and mitigate their negative economic and societal impacts
tracking health and ancestry impact of the greek colonisation in southern italy

the period of greek colonisation between 900 and 500 bc was one of the most formative periods of classical antiquity historical and archaeological research has greatly informed our understanding of this era but the exact nature and demographic impact of the colonisation process remains unclear the thais project will shed new light on this process by combining existing archaeological evidence with new ancient dna data based on the analysis of human skeletal remains from four archaeological sites in southern italy one of the focal points of greek colonisation using archaeological and molecular lines of evidence the project will address the following objectives 1 reconstruct the genetic ancestry and kinship structures of the local italic population in southern italy 2 investigate the origins of the greek colonists at two colonial sites metaponto and siris 3 assess nature and demographic impact of the greek colonisation by investigating possible admixture processes and sexbiased migration and 4 investigate the genetic legacies and lasting health impact of the greek colonisation in southern italy the thais project will be the first to use ancient dna analysis to study the impact of the greek colonisation and together with archaeological lines of evidence will provide new information on the colonisation process and the interactions between the colonists and the indigenous italic population at a key moment in mediterranean history