Dragon09/odtu_chatbot huggingface dataset:
advanced nano encapsulation of biobased pesticides and fertilisers for a circular and sustainable viticulture

the main objective of the vinny is the development of sustainable lowcost nanoformulated biopesticides nanobps and biofertilizers nanobfs for contributing to more resilient vineyard systems the application of vinny nanoformulations will allow contributing to the ultimate switch from intensive to sustainable agriculture in viticulture on a global scale this will be achieved using naturalbased green circular economy concepts i grapevine to grapevine plant full cycle approach where microbiomebased metabolites and bioactives from different vineyards in europe portugal spain austria and denmark will be investigated to form potent cocktails with antifungal and plant protection properties and ii industrial byproducts namely carbon and nitrogen n phosphorous p and potassium k npkrich actives from sludges originated from local waste water treatment plants wwtps in austria and denmark from meat industry mi to be used as biofertilizers the project is focused on stabilization and boosting the efficacy of these actives by using 2 different bioplatforms the nanoformulationencapsulation of bps and the impregnation on agrotextiles with bfs the platforms will be based on biodegradable renewable and abundant bioresources from plants or in the case of biopesticides on dynamically active nanoformulations ie based on stimuli responsive biopolymers with capacity of releasing the active and improving their efficacy upon external stimuli wind andor internal clues enzymes in fungi vinny will then validate these platforms according to their efficacy using in vitro ex vivo and in plant testing against vine prevalent pathogens and evaluate their biocompatibility confirm the absence of nanotoxicity and in field tests with the best performing candidates in 4 eu vineyards such endtoend development approach will allow for the optimization and adaptation of viticultural practices towards higher grape quality and productivity
ai supported picture analysis in large bowel camera capsule endoscopy

millions of europeans undergo optical colonoscopy oc every year oc may be associated with discomfort complications and sickdays which affect acceptability and constitutes a heavy burden on european hospital capacities colon capsule endoscopy cce is a new technology which has the potential to replace 50 65 of all ocs cce is preferred by patients has a lower complication rate and can be performed out of hospital cce holds great potential for both patients and hospitals however the diagnostic process of cce includes a timeconsuming manual reading done by trained personnel and is expensive and prone to human error for cce to be a viable alternative to oc these challenges need to be addressed thus our goal is to create a complete and validated aiassisted pathway that improves cce diagnostics making the technology clinically viable for the good of patients health care systems and society we have already completed development of several ai algorithms aia for cce diagnostics and more will be completed within 1 2 years the aice concept will focus on 1 completing development of the remaining aias 2 external validation the all aias 3 creating a clinical support system for data handling storage and transmission 4 developing a diagnostic pathway that considers quality efficiency patient preferences ethics and economy 5 promotes the integration of aice solutions into clinical practice via guidelines and upscaling adjustments to achieve these goals aice will use an unprecedented large and diverse collection of existing patient data from nationwide clinical studies and will include extensive initiatives in the fields of ethics communication and patient engagement to ensure the right competences are present aice brings together clinical researchers epidemiologists data scientists digital health experts health economists ethics researchers smes communication experts and experts in regulatory affairs
mediterranean afforestation and the loss of mountain cultural landscapes the case of zagori

despite summer wildfires and the expansion of urban and agricultural areas mediterranean mountains have experienced extensive afforestation during the last 70 years this has largely been a consequence of the abandonment of these areas and the loss of their traditional management strategies afforestation processes not just imply an important heritage loss as cultural landscapes disappear under the forest without having been studied but they also boost wildfires as traditional ways of managing the forests were not replaced by proactive forest monitoring undertheforest will study the cultural landscape under threat of afforestation and already afforested in the area of zagori greece identifying and dating its human and natural elements and linking them to specific historical and socioeconomical processes despite being considered an area of exceptional natural heritage zagoris cultural management has focused on its villages and their architectural elements overlooking the landscape that sustained them undertheforest will provide important data for zagoris ongoing bid for the unesco world heritage site as a cultural landscape in order to do so undertheforest will develop an innovative remote sensing workflow joining photogrammetric reconstruction for historical aerial imagery 1945 onwards machinelearning probabilistic classification of multitemporal multisource satellite imagery and dronebased lidar survey which will be able to locate structures under forest cover together with more traditional archival research pedestrian survey trench excavation and radiocarbon dating the project will identify and contextualise the cultural assets that made this landscape unique and provide new tools that can be applied to other areas currently under afforestation processes
impact of soil microbiodiversity on the development of wild mammal gut biota and immune function

the biodiversity hypothesis asserts there is a link between the diversity of environmental and hostassociated microbes and civilization diseases such as asthma and allergies the result of immune dysfunction and chronic inflammation using a wellstudied rodent model the bank vole soil2gut will test for the first time whether exposure to natural communities of soil microbes during development can improve individual health by promoting microbiota function at the hostmicrobiota interface ileum and colon mucous layers and reduce the risk of immunerelated diseases soil2gut will take advantage of tissue samples generated by an ongoing intervention experiment promoting the 3rs policy but also providing a unique opportunity for omics integration metataxonomics mtx innovatively this project will focus on the function of gut flora not merely taxonomical characterization in both bacteria and fungi the latter is particularly unusual using recent developments in metatranscriptonomics mtx to explore functional activity and combining metadata and metatranscriptomes in statistical models to identify critical factors determining health since 68 of the human population will be urbanized by 2050 soil2gut will contribute significantly to the who onehealth framework this project will also provide data that can be used to plan urban greenspaces enhance rewilding interventions and improve domestic and zoo animal wellbeing the researcher will build on his previous experiences and solid publications as a phdpostdoc receiving advanced personalized training in bioinformatics and soft skills including writing grant applications for expanding to other tissues lung skin and rendering him highly employable in exchange the researcher will bring methods for measuring individual health and immune gene expression to the hosting lab among others a synergy of expertise in microbiota research is envisaged leading to future collaborative endeavors
unconventional crafting of chiral azacompounds using visible light photocatalysis

the aim of chirazal is to devise innovative and sustainable technologies in organic synthesis to access general modular and scalable crafting of two families of biologically relevant chiral nitrogencontaining molecules namely azetidines and multisubstituted linear amines such molecules are characterized by a complex threedimensional arrangement and a high degree of saturation harnessing visiblelight as sustainable and unexpensive source of energy i will use a strainrelease approach to access these synthetically complex scaffolds asymmetric phase transfer catalysis and chiralmetal templated catalysis will be the foundation of this proposal for securing stereocontrol in order to accomplish the overarching goal of the research program it will be divided into two main stages an exploratory stage i followed by the consequently more applicative stage ii the application of the developed photocatalyzed transformations in flow technology will unlock a new and operationalfriendly pathway to azetidines and multisubstituted linear amines under mild and efficient conditions lastly the implementation of the developed chemistry as a functionalization tool will give access to a straightforward methodology which has serious potential to be embraced on any synthetic routethe multidisciplinary skills acquired due to the interaction between the two phases together with the transfer of knowledge between me and the hosting group will guarantee the successful realization of chirazal
surpassing traditional strength limits by additive manufacturing of innovative alloys

highstrength materials play a pivotal role in materials engineering offering exceptional durability mechanical reliability and an enhanced strengthtoweight ratio as a result they are in high demand across various industries including automotive aerospace and construction where they contribute to improved safety sustainability fuel efficiency and maintenance costs however the development of ultrahigh strength alloys has been impeded by challenges such as the strengthductility tradeoff and microstructural controlto overcome these limitations the stamina project aims to harness the potential of immiscible alloys combined with rapid solidification through laser powder bed fusion lpbf an additive manufacturing am method to fabricate alloys with unprecedented strength 25 gpa the innovative combination of fecu immiscible alloys and lpbf results in a unique microstructure characterised by fine grains and nanosized nanospaced precipitates formed during the rapid solidification of two immiscible phaseshowever the printing of immiscible alloys faces obstacles notably liquation cracking during lpbf to address these challenges the stamina project focuses on optimising laser parameters and alloy composition to achieve a defectfree microstructure with a uniform distribution of nano 25 nm precipitates and ultrafine grains with the latter leading to isotropic mechanical properties additionally the project pioneers the study of two liquid interactions under severe convection using highenergy xray analysisby integrating expertise from multiple disciplines including materials engineering am and fluid dynamics stamina seeks to establish theoretical foundations and innovative techniques for producing novel immiscible alloys the successful realisation of this research has the potential to unlock new frontiers for cuttingedge technologies which are currently limited by the availability of highstrength materials
aerosols convection clouds and climate sensitivity understanding the processes and climate impacts of the interactions between aerosol pollution and tropical convective clouds

interactions between anthropogenic aerosol particles and clouds are the largest source of uncertainty in the historical radiative forcing of climate aerosol effects on tropical deep convective clouds could constitute a major component of this forcing but the underlying physical mechanisms are poorly understood and the associated global climate forcing has not been rigorously quantified before these knowledge gaps have been highlighted as an urgent research challenge in recent assessment reports by the intergovernmental panel on climate change ipcc and the world climate research programme ac3s seeks to address this challenge by applying stateoftheart observational and modeling techniques that span the disciplines of aerosolcloud interactions and climate science first i will perform regional analysis of satellite observations insitu aircraft measurements and highresolution numerical simulations to investigate hypotheses about the physical mechanisms that govern the interactions between aerosols and tropical deep convective clouds second i will analyze global satellite observations to attain the first rigorous assessment of global climate forcing from these aerosolcloud interactions finally i will synthesize the evidence and quantify the implications of the results for earths climate sensitivity to carbondioxide forcing and 21st century global warming this integrated approach will advance the field of aerosolcloudclimate interactions and ensure that the results are immediately accessible to a broad audience including policymakers and future ipcc assessment reports
robust pemfc mea derived from modelbased understanding of durability limitations for heavy duty applications

the rd project pemtastic aims to meet the key technical challenges to increase durability of meas for hd applications these challenges are approached with a combination of modelbased design and the development of a durable ccm using innovative materials tailored for heavy duty operation at high temperature 105c the quantitative targets correspond to a durability of 20000 hours maintaining a stateof the art power density of 12 wcm2065 v at a pt loading of 030 gkwtruck mission profiles will be analyzed symbio in order to define relevant fc operation protocols and stressors degradation tests will be carried out in differential cells and will be assisted by physicalchemical material characterization to assure well defined data required for parametrization of degradation models cea dlr a combination of micro and mesoscale models as well as 1d and 2d cell models zhaw dlr will capture the impact of material parameters on performance and durability and will address all material and ccm parameters which will be iteratively adapted by industry partners the materials which will be implemented and adapted are advanced corrosion resistant supports imerys combined with a novel catalyst deposition technique heraeus to mitigate for ecsa loss prototype nafion ionomers and membranes with high conductivity in dry conditions will be used chemours eventually an improved cathode catalyst layer will be designed considering pt particle size distribution and superior catalyst ionomer interaction ird the selection of a commercial gdl will consider accommodation of a wide range of operating conditionsthe final mea and the concept of modelbased mea development will be validated in a short stack at trl4 symbio as additional outcomes implications on system management and on the bop components will be drawn and the reduced computational demand for degradation modelling will facilitate fast health assessment and performance prediction
taming dynamic complex media for imaging communications and photonic computing

the turbulent atmosphere flexible optical fibres and living tissue are all examples of opaque materials that change in time light propagating through these moving complex media is subject to intricate dynamic scattering effects transmitted optical fields are unrecognisably distorted in space and time such phenomena permeate realworld imaging and communications technologies they prevent microscopy deep into living tissue and hinder both freespace and fibreoptic data transmissionmy vision is the realisation of optical technology that automatically configures itself to dynamically cloak unwanted scattering effects of any opaque medium it is coupled to making it possible to look through to an unobstructed view of scenes on the other side the multimodal nature of this challenge calls for a raft of new sensing and light control techniques the aim of this proposal is to develop these technologiesi have begun to take some of the first experimental steps to achieve these goals i have developed a new form of adaptive optics that suppresses temporal rather than spatial light distortion i have also implemented prototype adaptive optical inverters capable of alloptically unscrambling light propagation through multimode optical fibres mmfs supporting 30 modes my project builds on these concepts and is delivered through 3 overarching objectives1 realtime monitoring of spatiotemporal scattering in dynamic complex media creating dynamic digital twins of complex media that evolve in realtime2 alloptically unscrambling dynamically scattered light building new types of programmable optical circuit driven by our digital twins to cloak spatiotemporal scattering effects3 applications reversing the scattering effects of mmfs and atmospheric turbulence enabling transmission of quantum entangled photons through noisy channels and finally investigating the broader implications of our technology to hybrid optoelectronic neural networks
towards a diachronic music theory

this proposal argues for a quantum shift in the way we theorize about music in the past three decades music theory has been dominated by synchronic theories based upon typologies the value of these theories notwithstanding there are three significant blindspots that arise from a purely synchronic perspective first synchronic approaches are incapable of explaining trends they at best capture snapshots along a timeline but cannot explain processes how one snapshot progressed to another second music written between two snapshots is evaluated in synchronic approaches either according to a defunct model or according to one that had not yet come into existence as often occurs with the music of the generation between bach and mozart third such snapshots mask trends during their period of interest behind a false façade of stability i propose to address this problem through a diachronic methodology designed to focus not on definitions and synchronic typologies but rather on processes of change over time to this end i will carry out a corpus study of unprecedented scope covering 1700 works between 16801819 in two overlapping subprojects based upon the same corpus i will examine trends in four fields largescale form phrase structure cadences musical units signifying closure and schemata stock musical phrases tracing the diachronic process of change across the decades of the corpus i will reveal the forces that propelled music from one style to another and through this the tensions with which composers were faced and to which they responded furthermore my novel diachronic approach will enable a more flexible mode of accounting for the fuzzy limits of theoretical definitions and histories lastly with its original conceptual premises and its corpusbased methodology this project will serve as a model for a new approach to music theory encouraging the embrace of a diachronic perspective in other fields of music theory too
natural language processing to learn the language of the human genome

natural language processing nlp models trained on text without explicit supervision can have groundbreaking performance they can develop a notion for grammar syntax and semantics thus learning the structure of language however while we have defined the rules in our language we only have a basic understanding about the linguistics of our genome in this project our goal is to treat the human genome as a sequence of text and apply nlp techniques to the human dna sequence we will establish bytepair tokenization to generate vocabulary from dna sequence and analyse attention maps to see the training relationship between different words of the genome we will then further investigate the language rules using methods from corpus linguistics together this will allow us to explore the grammar syntax and semantics hidden in the genome and capture their biological meaning for proofofprinciple we will perform several biological prediction tasks with finetuning models built on top of the pretrained model first we will take popular genomic prediction tasks to benchmark our approach such as predicting genome elements transcription and precision of genome editing then we will add some novel tasks around genome stability using available multiomics data throughout the project we will implement techniques for interpretable learning and strategies to observe control and prevent ethnic biases in our approach we expect for large language models to change how we as a scientific field approach genomics data analysis and expect our models to establish how these techniques can be applied efficiently transparently and in a biasreduced way in addition to general understanding of genome biology we plan to use our models in the future for technical improvements of data analysis population genetics and for translational uses with applications in cancer genomics and genome editing
thiophenylalanine a novel handle for peptide synthesis stapling and protein labelling

chemoselective functionalisation of peptides and bioconjugation of proteins has led to great advances in the synthesis of clinically relevant biomolecules and our understanding of cellular processes thiophenylalanine represents an interesting handle owing to the increased acidity of the aryl thiol which would mean a higher percentage of reactive thiolate would persist even at physiological ph allowing chemoselective reactions to be performed despite the interesting qualities of the residue there is a notable gap in its use in peptide and protein chemistry which can be attributed to the difficult and harsh conditions required involved in the synthesis often incompatible with common protecting groups herein we exploit a mild palladium catalysed method to obtain fmocsphetrt in one step from commercially available reagents to fully explore the possibilities of incorporating the building block into peptide and protein synthesis namely we will demonstrate the use of sphe 1 as a chemoselective method for peptide stapling 2 to perform onresin selective disulfide formation and attempt a regioselective onepot double disulfide formation of a novel antimicrobial peptide 3 as a method for discretely labelling protein residues through affinitybinding proximal transfer and 4 in the form of other aryl thiol building blocks to expand the scope of this work the development of a novel handle for bioconjugation will have an immense impact on the field of chemical biology and provide a tool for peptide analogue synthesis and elucidation of cellular processes