Dragon09/odtu_chatbot huggingface dataset:
enabling the next generation in search of blood cancer cures

the carreraspathfinder program is new a worldwide unique doctoral program that covers the entire spectrum of research and innovation in blood cancers from understanding disease biology to the implementation of novel processes in the clinical practice the program will fund 14 excellent doctoral candidates dcs for a period of 48 months dcs will perform collaborative phd projects involving associated partners from different sectors countries and disciplines through secondments dcs will improve their research capacity and transferable skills through highquality supervision arrangements and a tailored training programthe program has been designed and will be hosted by the josep carreras leukaemia research institute ijc which is the first european nonprofit institute exclusively devoted to blood cancers by answering the european needs for human resources it is fully aligned with the 13 recommendations of the eu cancer boards draft mission and the europes beating cancer plan 2021 the carreraspathfinder program has a strong triplei dimension of internationality intersectorality and interdisciplinarity in training networking cosupervision and research its specific objectives areto develop an excellent doctoral program in blood cancer research conceived as a pilot for a permanent international doctoral programto equip dcs with a unique skill set boosting effectiveness and innovation capacity to promote dcs career development and increase their employability in different sectorsto establish the ijc as a european reference for research and training in blood cancersto provide europe with a new generation of researchers able to address unmet needs and societal challenges of blood cancersto contribute to structuring the european research area by collaborating and synergizing with other european key opinion leaders
philanthropy sufism and legitimacy in the medieval islamic west the study of zawiyas as a socioreligious institution

this proposal aims to approach the social political and architectural dimension of the zawiya this is to say an islamic institution linked to sufism that has largely determined the religious life of the islamic west since the middle ages however its study has not been sufficiently developed so far and it has only been approached on a few occasions from stagnant perspectives which has limited the potential to advance in the knowledge of the medieval muslim societyin this respect after some previous attempts i have observed two relevant issues that require special attention on the one hand the concept of zawiya unlike other institutions has undergone an evolution throughout history and its current meaning cannot be extrapolated to past times on the other hand it seems to me that there is no single idea of zawiya and thereby we can reckon at least two different types that coexisted in the same spacetime and whose purposes differ significantly from each other due to their sponsor rulershaykh nevertheless there are several inconveniences that may have limited the visibility of both issues up to now representing thus a research challenge in the first place the semantic permeability of the term zawiya secondly the disappearance of the oldest examples thirdly the lack of coordination between documentary and material sources and finally the absence of accurate planimetric documentationin short this project suggests an interdisciplinary study on a group of examples that have been strategically selected to shed light on the above questions to this end after an indepth architectural survey various types of analysis and a confrontation with similar models and phenomena in the middle east will be implemented as host institutions the ucm spain the insap morocco and the oui israel will provide an excellent framework likewise it is expected a positive impact on the future conservation of some zawiyas of great historicalartistic value
cytokine signaling in macrophages beyond jakstat

dysregulated macrophage function underlies many inflammatory diseases cytokines small secreted signaling molecules with immunemodulatory functions shape the macrophages phenotype thereby affecting disease states puzzlingly many cytokines with opposing functions utilize highly similar jakstat signaling cascades leaving it unclear how cytokinespecific responses can occurin my previous work i studied enhancer activation in mouse macrophages from genetically different strains by studying genetic variation i found that transcription factor tf motifs crucial for enhancer activation can be identified i further developed the bioinformatic tool maggie to study tf motif mutations in different strains of mice which subsequently enabled me to discover a novel tf important for enhancer activation by the cytokine interleukin4 based on my findings i hypothesize that cytokines require specific yet unidentified tfs that cooperate with jakstat signaling to mount cytokinespecific effects cytomac aims to identify these cytokinespecific tfs downstream of jakstat that direct appropriate cell responses i will exploit the genetic variation across mouse strains and study enhancer activation in macrophages from these strains in response to different diseaserelated cytokines specifically i will 1 use genetic diversity between mouse strains to identify specific tfs regulating cytokinespecific responses to then target these novel tfs in 2 mouse and 3 human macrophages and 4 translate my findings to human disease and inflammatory disease modelsinhibitors targeting jakstat show high potential in clinically treating inflammatory diseases including rheumatoid arthritis however as they affect generic pathways of many cytokines they come with considerable sideeffects limiting applicability cytomac will reveal novel cytokinespecific tfs which will aid in developing better tailored intervention strategies
the molecular nexus coupling cell metabolism to cell cycle and genome surveillance

metabolic fluctuations and changes in dna replication and cell cycle dynamics orchestrate early development and tumorigenesis of particular interest are reactive oxygen species ros byproducts of basal metabolic reactions and major signaling molecules driving cell proliferation differentiation and cancer cell growth however despite their utmost importance in cell physiology how ros signals communicate to the cell cycle and genome safeguard mechanisms remains poorly explored my postdoctoral work has illuminated this topic by discovering novel redoxsensitive mechanisms that directly couple metabolic nucleotide fluctuations and oxygen starvation to dna replication dynamics these findings revealed that rossignaling could operate as a prime and cell cycle checkpointindependent surveillance for replicating genomes since profound alterations in metabolic pathways and redox state naturally entail embryonic growth cell differentiation and cancer transformation in such scenarios can metabolic cues in the form of ros align cell cycle states and dna replication in this application i propose to address this question by dissecting the mechanisms that align core cell cycle machinery and replisome dynamics to endogenous ros fluctuation in tailormade cellular models of early mammalian development stem cells and cancer by combining innovative analytical tools including crisprbased tagging of endogenous proteins with biochemistry and advanced cell biology eg quantitative singlecell imaging of redoxstate cyclincdks and genome caretakers replication fork sequencing i will define the molecular nexus coupling metabolism with genome surveillance at the global genomewide and local replisome level these investigations will provide an unmatched picture of regulatory foundations of cellular and genome integrity in normal and pathophysiological contexts enhancing understanding of genome surveillance in development mechanisms and disease
geometry processing as inference

geometry processing is concerned with algorithms and data structures for representing and processing threedimensional shapes techniques in geometry processing have been developed over the last three decades and are now driving realworld applications in various industries geometry processing algorithms may be interpreted as components of digital signal processing or machine learning solving inference problems given an incomplete description of the geometry commonly based on point samples the concept or process underlying the observations the surface is recovered unsupervised feature learning and then may be smoothed filtering segmented clustering or interactively modified semisupervised learning to facilitate these operations the surface representation is adjusted transcoding resampling however using the algorithms and data structures in geometry processing for data living in higher dimensional spaces requires fundamentally new methods in geometric computing emerge presents a research program aiming at making geometry processing methods available as a set of tools in data science emerge will introduce fundamentally new concepts for surface representations and computational methods for surface interrogation in dimension beyond three providing useful tools in various science and engineering disciplines the thesis of emerge is that the resulting extensions and generalizations of geometry processing techniques will be fruitfully complementing and adding to the state of the art in processing large amounts of data any progress in this direction will have profound impact as the proliferation of sensors and data processing has led to most of the current societal challenges climate change global biological risks population growth global policy making energy coming with enormous amounts of unstructured quantitative data to be analyzed
bioactive tissue sealant for enhanced wound repair

wound management is a routine part of medical practices worldwide and delays in healing cause a significant clinical and economic burden current tissue sealant formulations that are used for wound care pose various limitations including inability for filling in larger defects and release of toxic byproducts especially from synthetic polymers additionally most of the commercial sealants provide no bioactive properties or at best rely on bulk gf loading for inducing cell infiltration or tissue regeneration the development of a tunable bioactive hydrogel based tissue sealants thus provides an attractive opportunity as cellinstructive substrates for enhanced wound healingbiotisseal aims to develop the technology for fabricating offthe shelf bioactive tissue sealants that can not only help in wound closure or reduce blood loss but also stimulate better healing biotisseal will combine the tunable elasticity and adhesive strength of gelatin methacryloyl gelma prepolymers with angiogenic growth factor gf specific aptamers that are capable of sequestering and concentrating gfs that are already present in the tissue fluid at the wound site by coupling this to the controlled release behavior of aptamers a spatiotemporal control of gf bioavailability is achieved for enhanced wound repairbiotisseal will not only develop the technology to make this possible but will also take vital steps to bring this technology to the market by securing the ip and analyzing the market connected to biotisseal technology a fruitful basis for translation will be formed the inclusion of both a leading wound care company and a clinician in the advisory board will further ensure that biotisseal is optimally geared towards clinical translation
globalisation europe and multilateralism democratic institutions the rise of alternative models and mounting normative dissensus

gemdiamonds agenda speaks to a crosssection of the commissions political priorities for 20192024 most notably its push for renewed european democratic practices as part of a wider ongoing research programme on globalisation europe multilateralismthe project will delve into the impact of eu instruments on democratic institutions the rise of alternative models and presentday mounting dissensus driven by internal contestation and external competitionscientifically the project will result in research and training outputs that will be of direct benefit in terms of improved citizens knowledge and democratic practices expected innovations produced by the 15 early career researchers are anchored in 1 an original conceptual understanding of dissensus 2 a unique form of interdisciplinary and methodological coherence and 3 new empirical findings assessing the shifting efficiency and legitimacy of eu instrumentseducationally the project offers an integrated training curriculum that will foster excellent research further structure phd training at the european level and help set new global standards in the field the proposed consortium is uniquely positioned to provide highquality accredited degrees given that its members have decades of experience in the field and together have awarded over 50 double doctoral degreessocietally its dissemination exploitation communication efforts will have a sustainable impact on the european research era and higher education ehea areas rooted in its innovative practices and original research the project will boost the career prospects of 15 researchers promote innovative research practices standards with open science and encourage innovative democratic practices through citizen science platforms hosted across europe with an eye on ensuring all findings are readily available and directly exploitable this will strengthen the prospects of civic participation and liberal democracy in the eu
fuel cell ionomers from durable aromatic hydrocarbon polymers of intrinsic microporosity

vehicular transportation is responsible for a third of greenhouse gas emissions globally hydrogen fuel cells comprising of a proton exchange membrane pem coated with catalyst layers cls and sandwiched between gas diffusion layers generate electrical energy with high efficiency and zero emission the concern regarding a potential ban by the european union on the use of per and polyfluoroalkyltype forever chemicals that are currently used as pems and cl ionomers prompts us to seek sustainable alternatives such as aromatic hydrocarbons ah significant progress has been made to use ahs as pems due to their excellent thermal stability and ecofriendly synthesis however presently the specific adsorption of aromatic constituents on the noble metal catalyst and low gas permeability in the cl causes a performance penalty thus aggravating the use of ahs as catalyst ionomerthe aim of this project is to address these issues by developing a new class of catalyst ionomers based on ah polymers with intrinsic microporosity pims ah pims are expected to improve fc performance as highly gas permeable ionomer in the cl they facilitate chemical reactions and improve interfacial compatibility between cls and pemusing chemically durable polyphenylenes as scaffold we propose to synthesize a range of ah pims with enhanced gas permeability and chemical durability objective 12 university of yamanashi catalyst ink formulations will be prepared and coated on both sides of bestinclass ahbased pems to obtain catalyst coated membranes ccms with optimized morphology electrochemical surface area electrochemical activity and ionic conductivity objective 34 finally the performance and durability of the novel ccms will be evaluated in the single fuel cell at university of freiburg objective 5 this project will contribute to the increased market penetration of the fuel cell technology and to the realisation of a more sustainable society
mapping the axolotl brain and its regeneration

the axolotl is an extraordinary model system to study regeneration in tetrapods remarkably the axolotl isable to regenerate parts of the brain after major injury however the molecular mechanisms that orchestrateregeneration are unclear and the completeness of functional circuit and behavioral recovery is unknown ourvision is to develop the axolotl model system to rigorously study central nervous system regeneration anduse discoveries from the axolotl to design novel strategies for regenerating mammalian tissues the mappingof brain cell types and connections in the axolotl will also have a profound impact on the understanding ofvertebrate brain organization and evolutionin axobrain we will integrate scalecrossing technologies to map the axolotl brain at molecular cellularand circuit resolution and establish assays to understand how brain cells respond to damage and behavioralcircuits regenerate our project will be achieved through the following objectives 1 we will generate aspatiotemporal multiomic atlas of the axolotl brain at single cell resolution 2 we will generate aconnectome of the axolotl retinotectalhindbrain circuit and develop behavioral and circuit functional assaysin response to visual stimulation 3 we will establish injury assays and assess regeneration throughbehavioral connectomic and singlecell multiomic analysis 4 finally we will apply crispr perturbationscreens with singlecell genomic readout in vivo and in vitro to identify modulators of regenerationaxobrain utilizes quantitative and stateoftheart methods to explore how the axolotl can regenerate neuralcircuitry after injury we have assembled a team with synergistic skill sets that will be required to achieveour vision this project is a groundbreaking starting point to rigorously investigate how mammals have lostregeneration capabilities over evolution and will serve as a springboard to design novel strategies forregenerating
high performance edge and cloud computing

the objective of hipeac is to stimulate and reinforce the development of the dynamic european computing ecosystem that supports the digital transformation of europe it does so by guiding the future research and innovation of key digital enabling and emerging technologies sectors and value chains the longer term goal is to strengthen european leadership in the global data economy and to accelerate and steer the digital and green transitions through humancentred technologies and innovations this will be achieved via mobilising and connecting european partnerships and stakeholders to be involved in the research innovation and development of computing and systems technologies they will provide roadmaps supporting the creation of nextgeneration computing technologies infrastructures and service platformsthe key aim is to support and contribute to rapid technological development market uptake and digital autonomy for europe in advanced digital technology hardware and software and applications across the whole european digital value chain hipeac will do this by connecting and upscaling existing initiatives and efforts by involving the key stakeholders and by improving the conditions for largescale market deployment the nextgeneration computing and systems technologies and applications developed will increase european autonomy in the data economy this is required to support future hyperdistributed applications and provide new opportunities for further disruptive digital transformation of the economy and society new business models economic growth and job creationthe hipeac csa proposal directly addresses the research innovation and development of next generation computing and systems technologies and applications the overall goal is to support the european value chains and value networks in computing and systems technologies across the computing continuum from cloud to edge computing to the internet of things iot
resilient northern overturning in a warming climate

a vigorous atlantic meridional overturning circulation amoc is crucial for the mild northern european climate it brings warm water northward near the surface and returns cold dense water at depth in a warming climate the amoc is projected to weaken or even approach a tipping point contrary to this established view i hypothesize that an overlooked climatechange induced mechanism may impart resilience to the overturning as the sea ice recedes increasing stretches of the boundary current system around the nordic seas and arctic ocean become exposed to the atmosphere the resulting increased ocean heat loss in winter further densifies the water in the boundary current which is a direct pathway supplying the lower limb of the amoc enhanced densewater formation is counterintuitive in a warming climate and not represented by current climate models but has the potential to safeguard the northern overturning and maintain a steady supply of dense water to the amoc sparse observations and preliminary results from a 1d model indicate that water mass transformation occurs in the increasingly icefree boundary current but its extent importance and future development are unknown in rover i will explore this concept through an extensive field campaign which includes a mooring array across the boundary current and an unprecedented wintertime survey of this severely undersampled area combined with targeted highresolution modeling i will use the comprehensive data set to document the occurrence of this process understand its dynamics quantify its extent and assess its climatic importance densewater formation in the boundary current system that may safeguard the northern overturning would represent a paradigm shift for water mass transformation at high latitudes and the stability of the overturning circulation as such rover is timely and will have a substantial and significant impact on the science of climate change and climate impact assessment
hybrid tandem catalytic conversion process towards higher oxygenate efuels

carbon neutral highenergy density efuels are crucial to defossilize longhaul transport mildly oxygenated compounds such as c5 higher alcohols and their ether derivatives hold the promise to overcome limitations of known efuels such as nonoxygenated fischertropsch hydrocarbons or heavily oxygenated methanol and dme but no process exists for their effective production the project aims to develop a disruptive route wherein co2 water and renewable power are converted to higher oxygenate efuels in a oncethrough hybrid process integrating three major catalysis branches electrocatalysis is applied in a robust highpressure co2h2o coelectrolysis step to produce esyngas h2co which is converted in a singlereactor slurryphase process combining solid thermocatalysis for linear hydrocarbon synthesis and molecular chemocatalysis for in situ oxofunctionalization via reductive hydroformylation in this process integration of catalytic functionalities in tandem alongside an engineered interfacing of high and lowtemperature conversion steps and energy unintensive membrane separation technologies offer a blueprint for superior atom and energy efficiencies the project will demonstrate the new efuel production process at benchscale and assess its capacity to cope with fluctuating energy inputs moreover efuel formulation and lifecycle aspects are covered to fully realize the potential of the higher oxygenate efuel to distinctively unite excellent combustion properties high cetane exceptional reduction of tailpipe soot emissions advantageous logistics as liquid at ambient conditions and compatibility with currentfleet fuel infrastructure and engine technologies with emphasis on applications as diesel replacement in heavyduty marine transport an exploitation plan will be created together with international stakeholders to consolidate eus capacity to export advanced efuel technologies to areas with vast green energy potential