Dragon09/odtu_chatbot huggingface dataset:
a bioarchaeological study of 1800 years of resilience and adaptation to urbanity

citylife explores from a bioarchaeological perspective how historical populations adapted to an urban environment and developed resilience to the disadvantages of urban life by exploiting the vast amount of information contained in human skeletal remains the project will clarify the roles of biological factors in the durability and sustainability of preindustrial urban societies newly developed osteological chemical isotope and genomic methods will be used in this project together with cuttingedge tools for statistical evaluation citylife will evaluate the living conditions economy population structure pathogen load and immune defenses in a sample of more than 4500 skeletons from a hotspot of european urban culture thessaloniki this city in northern greece still exists today and in historic times it formed a bridge between the roman west and the byzantine east thessaloniki offers the unique constellation to study urban life from 300 bc to ad 1500 and thus to draw inference about an urban population in a single place continuously over 1800 years the main objectives of the project are to a infer urban living standards by studying secular changes in anthropometric indexes infant diet childhood stress and trauma in a combined manner b investigate the resilience and sustainability of urban food systems by reconstructing individual diets and local supply networks d investigate social structures religious cohabitation and migration by genetically reconstructing the degree of kin and nonkin relationships and e explore the effects of pathogen exposure on human evolution and health by studying genes associated with increased immunological response and the oral microbiome citylife will examine empirically tangible aspects of biocultural development to answer the simple question of how humans became urban species
microbial activity at the bentonite barrier in a deep geological nuclear waste repository

management of nuclear waste is a serious worldwide environmental problem all deep geological repositories have been internationally proposed as the safest option for the disposal of these hazardous materials the concept is based on a multibarrier storage system with waste containers surrounded by a bentonite buffer buried deeply within a stable geological formation the bentonite formations in almeria were characterized as a bentonite buffer reference material however few studies have described the influence of the microbes in the repository under in situ conditions although its safety can be compromised not only by physical and chemical factors but also by biogeochemical activity therefore the hypothesis to be tested in this proposal is that indigenous microorganisms may play an important role for the safe disposal of nuclear waste the main objective of this proposal is to study the microbial diversity and activity of the bentonite buffer under in situ conditions for a repository of radioactive waste to address these points the following objectives will be carried out under in situ conditions 1 to characterize the mineralogical and geochemical composition of the bentonite buffer 2 to determine the microbial of the incubated bentonite buffer 3 to determine the microbial activity of the incubated bentonite buffer this proposal will extend the stateoftheart for nuclear waste repositories by identifying active microorganisms in compacted bentonites and natural deep groundwaters and active microbial metabolic pathways these vital questions need to be addressed to ensure the safety of the deep geological repository of nuclear waste but also for other biotechnological uses like bioremediation of contaminated sites
modeling binary neutron star from inspirals to remnants and their multimessenger emissions

binary neutron star mergers bnsms are unique astrophysical laboratories to explore all four fundamental interactions in their extreme regimes the landmark detection of the gravitational wave gw170817 and its counterparts in the entire electromagnetic spectrum demonstrated the enormous impact of bnsms observations on fundamental physics and astrophysics including the nature of matter at supranuclear densities the origin of highenergy cosmic photons and of heavy elements the goal of inspirem is to break new grounds in the theoretical modeling of bnsms and to deliver firstprinciples models linking the source dynamics to the observed radiations the programme timely addresses central open problems in the modeling of the different coalescence phases with a novel comprehensive generalrelativistic 31d and multiscale approach simulations and analytical relativity methods are combined to deliver fullspectrum gravitationalwave templates for unbiased highprecision measurements in gravitationalwave astronomy merger remnants and outflows are investigated on uncharted postmerger timescales and including for the first time all the relevant processes from the four interactions the selfconsistent secular evolution of the outflows up to days and years is further explored to directly connect the stronggravity engine to the electromagnetic emission bayesian approaches with simulationdriven models are developed for the joint analyses of gravitational and electromagnetic signals inspirem leverages on recent breakthroughs and the unique interdisciplinary expertise of my team on all the aspects of the research and develops novel techniques for exascale parallel computations in relativistic astrophysics if successful it will shape the rising field of multimessenger astronomy and drive new groundbreaking discoveries in the related fields
quantum manybody dynamics and noisy intermediatescale quantum computers interconnections nearterm applications and novel simulation schemes

simulating the dynamics of quantum manybody systems is notoriously difficult as the computational requirements grow dramatically with increasing system size while fullyfledged quantum computing may provide a means to handle this challenge todays noisy intermediatescale quantum nisq devices are prone to errors and decoherence this interdisciplinary project promises significant progress in the understanding of nonequilibrium quantum systems and in leveraging the capabilities of nisq devices for this purpose the innovative research is going to capitalize on the concept of quantum typicality to explore nearterm applications of random quantum states on nisq devices and to study the emergence of hydrodynamics in isolated quantum systems by combining stateoftheart theoretical and numerical approaches with simulations on available quantum hardware important insights will furthermore be gained into the universal properties of quantum dynamics in drivendissipative systems in monitored circuits consisting of unitary gates and projective measurements and in manybody localized systems coupled to a thermal bath tackling these key areas will provide a deeper understanding of fundamental physics and will unravel the inevitable interaction of nisq devices with their environment results may open up new avenues for robust and scalable simulations on nisq devices which is vital as quantum technology continues to mature additionally this project will deliver novel nisqinspired classical simulation schemes which are memoryefficient and will pave the way to answer open questions that are challenging for other methods highlighting the strong synergy and profound interplay between quantum manybody dynamics and nisq devices this project follows horizon europes strategic plan of developing key digital and emerging technologies and is in line with europes quantum flagship initiative to foster european excellence in quantum technologies
wholeorgan 3d ultrasound microflow imaging from basics physics to clinical proofofconcept on cardiac and cerebral diseases

blood circulation is essential to organs functions and occurs through a complex network of vessels with diameters varying from several millimetres for large arteries to only a few microns for small capillaries dysfunctions in the microcirculation are early markers of many diseases which are however diagnosed at later stage when observable symptoms become visible at larger scales mapping blood flows across several spatial scales at depth in organs is therefore crucial for early diagnosis and monitoring of diseases but it remains a major challenge in clinical medical imaging our laboratory physics for medicine paris has introduced in 2015 ultrasound localization microscopy ulm a noninvasive method to map and quantify blood flows at depth in organs down to a micron scale resolution opening avenues for medical imaging however 2d ulm is highly operatordependent because probe positioning is critical to view the appropriate crosssection imaging the wholeorgan in 3d is therefore crucial for clinical practice and for a comprehensive investigation of organs functions capturing large 3d volumes through the bones such as the skull or the rib cage is a further challenge in ultrasound imaging acoustic energy losses due to reflection and distortion of ultrasound waves at the bone interface significantly reduce the imaging sensitivity the objective of microflowlife is to develop ultrasensitive 3d ulm through bones for mapping the microcirculation of the wholeheart and the wholebrain our approach relies on the development of novel ultrasonic multilens probes combined with new acquisition sequences and processing methods our technology and methods will be first validated in vitro and in vivo and then translated clinically in firstinhuman studies feasibility of cardiac and cerebral applications will be assessed in two morbid diseases associated with microcirculation alteration coronary microvascular dysfunction and brain glioblastoma tumors
aipowered robotic material recovery in a box

recyclable materials recovery is a key element of the circular economy and the eu green deal it is typically performed manually at large scale material recovery facilities mrfs installed close to dense urban areas recent advances in ai and robotics have enabled the automation of several mrf activities however they target large waste volumes and are not costeffective for smaller less accessible areasto accommodate the latter portable material recovery units can be deployed nearby despite the increasing demand for portable units offerings lack intelligent automated components that could significantly increase their productivityto fill this gap reclaim will develop a portable robotic mrf prmrf tailored to smallscale material recovery the proposal exploits welltested technology in robotics ai and data analytics which is improved to facilitate distributed material recoveryreclaim adopts a modular multirobotmultigripper approach for material recovery based on low cost robotic recycling workers rorewos an ai module combines imaging in the visual and infrared domain to identify localize and categorize recyclables the output of this module is used by a multirorewo team that implements efficient and accurate material sorting further a citizen science approach will increase social sensitivity to the green deal this is accomplished via a novel recycling datagame that enables and encourages citizens to participate in project rtd activities by providing annotations to be used in deep learning for the retraining of the ai modulereclaim developments will be implemented and repeatedly assessed in demanding real material recovery tasks three different scenarios will attest its effectiveness and applicability in a broad range of locations that face material recovery challenges this will pave the way for the prmrf market uptake and provide a major boost in making europe zero polluting climateneutral sustainable and globally competitive
coevolens disentangling the microevolutionary mechanisms of coevolution

coevolution characterized by reciprocal trait changes driven by mutual selection between interacting species is pivotal in shaping biodiversity however understanding the genetic basis and mechanistic processes underlying coevolution in natural populations remains challenging this project aims to bridge this gap and connect coevolutionary theory to empirical data by using the wellestablished lithophragmagreya moth pollination system as a study model by identifying and quantifying the genetic variance of key traits mediating this interaction we will assess their potential to evolve a critical aspect in coevolutionary dynamics additionally we will investigate natural selection in this system considering both female seed set and male siring success fitness components and examine how ecological context including the presence of copollinators affects selection we will employ ecological network analysis and interaction effectiveness measurements to determine the significance of specific interactions in driving coevolutionary processes this research will enhance our understanding of the genetic underpinnings and ecological factors influencing trait coevolution in pollination interactions shedding light on the evolutionary dynamics within complex ecological networks coevolens will provide valuable insights into a species ability to adapt to a changing world where the loss of species interactions is a major concern
a revolutionary archaeological pb observatory for astrophysical neutrino sources

one of the most energetic events in the universe is the corecollapse supernova sn where almost all the stars binding energy is released as neutrinos these particles are direct probes of the processes occurring in the stellar core and provide unique insights into the gravitational collapse and the neutrino properties currently astroparticle physics is in need of sn observations and of a detection technique highly sensitive to all neutrino flavorsresnova will revolutionize how we detect neutrinos from astrophysical sources by deploying the first array of cryogenic detectors made from archaeological pbneutrino detection in resnova is facilitated by the newly discovered coherent elastic neutrinonucleus scattering cevns it enables the first measurement of the full sn neutrino signal eradicating the uncertainties related to flavor oscillations to fully exploit the advantages of cevns resnova ennobles pb from being a passive shielding to the most sensitive detector component pb has the highest crosssection 104 times higher than all used detection channels enabling the deployment of a cmscale neutrino observatorythe unconventional approach of resnova is to use ultrapure archaeological pb and run it as a cryogenic detector with lowenergy threshold 1 kev and unprecedented background 0001 ctonkevs these features also open new opportunities in multimessenger astronomy dark matter and neutrino property studies the success of my pioneer work in operating archaeological pbbased cryogenic detectors is pivotal for resnova realizationresnova will survey 90 of the potential galactic sne with only a total detector volume of 30 cm3 future detector upgrades will enhance our snsensitivity into the uncharted territory 1 mpc and increase the sn observation rateresnova has the potential to lay the foundations for a future generation of european neutrino telescopes as all its sn neutrino detectors are currently going offline
innovative solutions across the mediterranean for mitigation of climate changerelated health risks and enhancing health system resilience

ismedclim aims to engage and mobilise regional stakeholders across the mediterranean in implementing a wide array of adaptation solutions to mitigate the health effects of climate change and provide evidence for their feasibility user acceptance and efficacy specifically ismedclim will i enhance the understanding of climate change effects on noncommunicable diseases ncds and vectorborne infections across representative european countries within the mediterranean ii quantify for the first time how public health interventions integrating stateoftheart technologies public and social media with vulnerable citizens participation can reduce personal exposures to heat and air pollution and related health effects iii validate the feasibility and user acceptance among high risk professionals of a regional early warning and risk prediction tool to mitigate the risk posed by exposure to sand flies and related diseases iv employ open participatory and cocreative methodologies to locally adapt and refine existing evidencebased practices and prototype tools to increase the preparedness and ability of health systems in the mediterranean to deliver safe effective and efficient care to citizens we will test the proposed demonstration solutions initially in eight sites and coordinate ten replications in six sites in five european countries cyprus greece italy spain portugal in alignment with climate change adaptation mission objectives we will integrate the produced knowledge from epidemiology forecasting exposure and health data with insights from the demonstration and replication activities into a knowledge portal and policy decisioncentric and actionoriented dashboard for policy makers healthcare administrators professionals and citizens ismedclims approaches will be readily applicable in other european regions affected by the same or other climate changerelated stressors such as forest fire smoke floods ozone and cold
design build and test of novel bacteriadelivered proteins for cancer therapy

conventional cancer therapies have many limitations that could potentially be overcome using engineered tumour targeting bacteria as cancer therapeutics these bacteria have been shown to selectively grow in tumours where they can produce and deliver therapeutic biomolecules proteins extracellularly in the tumour microenvironment however the delivery of these biomolecules into the cytoplasm of targeted tumour cells remains a challenge limiting the clinical translation of these therapies bacstar aims to address delivery challenges by designing multipart multifunctional proteins that transport themselves from the interior of the bacterium into the cytoplasm of cancer cells where they can exert therapeutic action these proteins will integrate protein motifs for transport using novel cell penetrating peptides and anticancer activity which will be assembled using recently developed computational protein design workflows a modular designbuildtest synthetic biology approach will facilitate measurability and experimental throughput novel proteins will be tested in vitro and in vivo with highthroughput methods available at host labs this interdisciplinary approach is enabled by leveraging cuttingedge expertise and technologies in computational protein design from the bhardwaj and baker lab at the institute for protein design uw usa and in bacterial cancer therapy available at the tangney lab ucc ireland an international intersectoral placement at prokarium uk will support the clinical translation of outputs from this project and build my expertise in translational research which will inform the commercialisation route of this and future projects my longterm career aim is to develop bacteriadelivered protein therapeutics bacstar is a significant career opportunity to transition to independence with the active support of world leaders in their fields and gaining industry rd experience which is key for the advance of these biotherapeutics
feedback levitation on an inverted potential a new tool for macroscopic quantum physics sensing and information thermodynamics

the control of levitated mesoscopic objects has developed into a flourishing field promising significant advances in sensing technologies stochastic and quantum thermodynamics as well as macroscopic quantum physics while optical levitation has already reached operation in the quantum regime internal heating by absorption is a major challengewith flip feedback levitation on an inverted potential we propose an original solution dark field optical detection plus active feedback control provides position stabilization without additional confining potential and cooling to a closetopure quantum state without absorption flip goes beyond the state of the art in several ways it provides access to quantum control of absorbing objects in high vacuum eg spin mechanics with nvcenters it opens the door to large quantum superpositions via freefall experiments with internally cold particles it enables sensing and information thermodynamics with unstable potentials in the quantum regimefollowing the recent demonstration of quantum limited position readout realtime state reconstruction and feedback cooling to the ground state it is the ideal time to develop levitation in the dark optical field a controllable inverted potential for levitated particles is available in the host group such that the project can be implemented from day zero and expanded towards a 3d dark quantum trap close collaboration with the aspelmeyer group partner group and prof kugi acin who jointly achieved feedback based ground state cooling will facilitate the implementation of flipmy expertise in fpgabased optical feedback control puts me in a perfect position to implement flip at the host group i will expand my background in optomechanics and quantum optics finally continuing my research in information thermodynamics using flip the proposed research will if successful sharpen my unique research profile and open fruitful research directions for my future career
intensified tuberculosis treatment to reduce the high mortality of tuberculous meningitis in hivinfected and uninfected patients

tuberculosis tb remains a global health problem the most lethal and disabling form of tb is tuberculous meningitis tbm with an estimated 100000 new cases occurring per year in subsaharan africa tbm mortality reaches 40 in hiv negative patients and up to 70 in hiv coinfected patients since decades tbm treatment is based on a regimen used against pulmonary tb which probably results in suboptimal drug levels in the cerebrospinal fluid csf the main objective of intensetbm is to reduce the mortality and neurological complications of tbm in adults with or without hiv coinfection in subsaharan africa ssa this is investigated via a multicentre randomised multicentre phase iii clinical trial involving 768 patients in four ssa countries to evaluate the efficacy of an intensified tb treatment regimen during the first two months of tb treatment including highdose rifampicin and linezolid repurposed drug with the addition of aspirin not as yet authorized for tbm this intensified tb treatment is expected to reduce mortality by at least 30 for each of the interventions and minimize neurological sequalae the intensetbm trial is the largest ongoing trial in the field of tbm worldwide if superiority of this experimental arm is demonstrated in terms of reduced mortality it will become the first phase iii study to demonstrate survival benefit from intensified tbm treatment as per the expected outcomes of this edctp3 call intensetbm2 as the continuation of intensetbm a clinical trial funded by edctp2 and whose activities were disrupted during the covid19 pandemic aims at concluding the ongoing activities of the edctp2 project it also aims at complying with ethical issues such as fully validating the willingness of trial participants to take part in the clinical investigations