Dragon09/odtu_chatbot huggingface dataset:
network for crossdisciplinary assessment of endocrine disrupting compounds training the next generation of toxicologists

the eu has flagged endocrine disrupting chemicals edcs which interfere with normal hormonal function leading to adverse health effects of particular concern within different eu regulatory programmes the assessment of edcs has recently changed significantly and continues to evolve rapidly advances in test methods for assessment of edcs are needed to meet these changing regulatory requirements and a new generation of toxicologists must be trained to support the implementation of the most advanced approaches nexed will address three critical challenges in this area first human and environmental edc assessment have historically been separate disciplines while there is an increasing need to use data across species in a one health approach second edc assessment currently addresses single compounds while in an environmentally realistic scenario organisms are faced with complex mixtures of edcs third new test methods for edc assessment are needed covering less wellcharacterised mechanisms and effects nexed aims to facilitate a paradigm shift in edc assessment by training a new generation of crossdisciplinary toxicologists specialised in using harmonised approaches in a one health framework nexed will train its 15 doctoral candidates through research secondments and training events using an interdisciplinary and intersectoral training programme nexed brings together 9 beneficiaries and 11 associated partners from 10 countries building upon longstanding collaborations through existing projects including the horizon 2020 eurion projects and the horizon europe partnership on the assessment of risk from chemicals parc the consortium includes leading researchers from institutions with excellent doctoral training programmes who are all experts in ed assessment as well as industry partners regulatory agencies smes and consultancy firms with its complementary expertise the consortium is ideally placed to train the nexed generation of toxicologists
examining effects of daytime naps on memory consolidation and emotional reactivity in a wellpowered preregistered multilab collaboration

this proposal will examine if a daytime nap improves memory consolidation with the largest and most diverse sample size of any study ever conducted on this topic we will achieve this through a preregistered multilab collaboration with contributing sleep labs from all over the world previous research has indicated that sleep is beneficial for memory consolidation it has further been suggested that sleep mainly consolidates emotional memories and that sleep helps to reduce the emotional reactivity associated with emotional experiences recent metaanalytic work has however revealed that previous studies on this topic have been massively underpowered and that selective publishing of positive findings is a major problem in the fieldthe study will have a withinsubject crossover design participants will come to the lab in the early afternoon and encode neutral and negative images for each image they will also rate the emotional response it elicits participants will then either take a nap monitored with polysomnography or spend an equivalent amount of time awake and then have their memory performance for the images tested and rate their emotional response to the images once again this research design will allow us to answer the following questions a will sleep as compared to wake increase memory consolidation b will this sleep dependentconsolidation benefit be more pronounced for negative compared to neutral items c will any particular sleep stage be especially involved in memory consolidation d will sleep as compared to wake decrease the emotional reaction to previously viewed images by doing this as a registered report we will increase transparency and reduce risk of selective reporting of significant results this study will for the first time produce robust and reliable estimates that will inform us about the putative benefits of promoting sleep in the immediate aftermath of learning experiences andor negative events
survivability assessment cost reduction pathways and environmental evaluation of offshore installed floating solar energy farms

europe is currently in a transition away from its dependency on russian gas towards a fully renewable reliable and lowcost energy system by 2050 to achieve this target largescale renewable energy projects are essential however the transition is limited by several factors such as onshore space availability to deploy gwscale projects supply chain disruptions and concerns from various stakeholders around visual pollution and space use offshore floating pv ofpv can deliver hundreds of gws in europe by 2050 while resolving above challenges in areas with a fastexpanding offshore wind sector eg north sea ofpv can be combined with wind inside multisource farms this enables the extraction of up to 9x more energy per km2 and better utilization of the infrastructure due to 1020 more fullload hours while leaving space for other stakeholders as fewer wind parks and electrical infrastructure are needed for the same amount of electricity production in parts of the mediterranean and the black sea with low wind resources also standalone ofpv can help to achieve high penetration of renewable energynautical sunrise will remove the last barriers of ofpv to deliver these benefits a 5 mw gridconnected multiyear offshore demonstration of a highly competitive ofpv system and its components inside a commercial wind farm will provide the trust needed for the upscaling of the technology prior to the demonstration its technical reliability will be validated in the most extreme conditions through laboratory measurements wavewind tank tests and modelling studies the cost reduction achieved through design improvements will be quantified in concrete business cases and should enable an lcoe of 148 mwh making ofpv financially viable additionally the measurement campaign at the ofpv demonstration largescale environmental modelling and lifecycle assessment including circularity will help to understand the overall effect on the environment
a proactive approach for communities to enable societal transformation

procoast will develop apply and validate a cuttingedge operational framework in the study of coastal ecosystem dynamics for the benefit of the population most exposed to risk deriving from biodiversity loss such a framework needs to tackle the complex socialecological issues at hand particularly so because these issues involve a dynamic perspective on the social as well as its interaction with the ecological system hence the procoast framework will be based on the integrative social ecological systems framework sesf based on the seminal work of the late nobel laureate elinor ostrom procoast will apply and validate its holistic framework for identifying the interactions and dynamics of the different subsystems in a set of nine representative case studies located on the european continent both in eu and noneu areas covering all five european coastal regions the coastal ecosystem is the common thread running through all the case studies but each one presents a specific issue and framework in each case study we will cocreate together with local stakeholders a set of tools and policies for the successful implementation of biodiversity conservation projects two approaches the bristol approach the extreme citizen science ecs framework to cocreation will be used to develop and establish a participative approach which is by virtue responsive to local contexts in line with procoasts overall objective to increase capacity and resilience within the transformative communities a change process will be initiated taking into account technical and social capacity while the technical side of the change comprises new technologies and services regarding biodiversity the social side of the change focuses on the humans openness and readiness for change to achieve its goals procoast brings together 20 organisations across 14 different countries selected on criteria of experience expertise and most of all complementarity and interdisciplinarity
onboard monitoring of inservice trains for the structural health monitoring of railway bridges

railway systems are expanding rapidly worldwide as a green means of transportation such rapid expansion poses a challenge toguaranteeing safety and ensuring the quality of railway systems continuous monitoring of tracks and rail bridges can help diagnoseand prognose damage timely increasing railway transportation reliability in this project we focus on rail bridges whose conditionassessment traditionally relies on a static network of sensors although wellestablished this technique lacks portability entailsconsiderable cost and effort and crucially inhibits continuous monitoring as the lifespan of sensors is generally smaller than that ofthe bridge to tackle these limitations indirect monitoring practices have recently gained attraction such methods extract thedynamic properties of bridges via measurements from traversing vehicles by exploiting the vehiclebridge interaction vbi principlethis way they offer mobility and lower installation and maintenance costs however the majority of studies on indirect monitoring ofbridges focus on highways despite the similarities of vbi modelling between highways and railways distinct differences eg vehicleand contact models moving speed loading patterns do not allow the direct application of current indirect monitoring methods torailway bridges another challenge is the blurring effect of surface roughness which simplistically is typically considered as known oris eliminated to this end this project proposes a consistent methodology to continuously monitor railway bridges via onboardmonitoring of inservice trains with a simultaneous characterization of the involved roughness profiles accordingly it proposes ahybrid modelling procedure that considers a vbi model which represents actual trainbridge systems and considers the roughness ofthe involved track system fused with vibration measurements collected from traversing trains
exposing hidden electronic configurations in atomically thin superstructures with extreme light

lightinduced phase transitions in solids present a tantalizing opportunity for controlling the constituents of matter an intense optical excitation with a duration on the order of femtoseconds can trigger nonthermal electronic and structural configurations switching the excited material into a hidden phase that may be exploited to realize new technologies such as ultrafast memory devices a general picture of the microscopic processes underpinning hidden phases has not been established their existence has therefore only been exposed in a handful of systems presenting a major obstacle for achieving ondemand quantum materials with lightdrawing inspiration from these unique systems i hypothesize that materials with a strongly correlated phase that is pinned by a twodimensional superstructure provide a trajectory to a lightinduced hidden phase the objectives of excite are a to establish the experimental parameter space to determine the electronic structure of hidden phases in bulk and singlelayer correlated transition metal dichalcogenides b to demonstrate the existence of hidden phases in optically excited moir superstructures that simulate strongly correlated behavior and c to exploit the wide tunability of these systems in order to disentangle the general microscopic degrees of freedom that govern the trajectory into a hidden phasethe objectives will be accomplished by establishing a stateoftheart experiment to optically excite in situ prepared materials and probe their electronic structure during phase transitions with nanoscale spatial resolution and femtosecond time resolution these groundbreaking capabilities will be realized by integrating a highpower laser system with my new synchrotron beamline for nanoscale photoemission spectroscopy nanoarpes at the astrid2 light source aarhus university my experiments will enable me to critically assess basic assumptions in the field and move the boundaries of ultrafast science
epithelialmesenchymal crosstalk in the pathology of influenza virus infection

influenza virus infects the airway epithelium the connective tissue underneath the epithelium consists of extracellular matrix ecm produced mainly by fibroblasts small airway fibrosis characterized by fibroblast activation and excessive deposition of ecm is emerging as the key driver of the progression of chronic obstructive pulmonary disease copd a very common and lifethreatening lung disease for which no cure exists irreversible progression of copd is often triggered by influenza virus infection however causative mechanisms between influenza virus infection and small airway fibrosis have not been explored in this project the fellow will infect an advanced coculture model of patientderived airway epithelial cells and fibroblasts from the human lung to mimic the microenvironment of the airway cellular and molecular profiling of the fibroblasts will be performed by an unbiased approach using integrated and interdisciplinary methods especially a unique mass spectrometry and bioinformatics workflow for deep molecular profiling of the ecm will be combined with stateofthe art single cell rnasequence analysis to discover profibrotic readouts then she will use cells from copd patients to translate the findings to the clinic finally she will establish a hostgene specific knockdown coculture model to elucidate the role of a specific protein that interacts with the ecm and assess the druggability of this potential target the fellow is a pathologist from japan with extensive experience in infection with animal models her expertise and knowledge in disease pathology will be integrated with the hosts prestigious scientific environment establishment of international connections will facilitate her to become an academic leader with a unique and multidisciplinary profile to combat infectious diseases of the lung
understanding predicting and treating depression in pregnancy to improve mothers and offspring mental health outcomes

happymums is designed to improve our understanding on the biological mechanisms underlying the development of depressive symptoms in pregnancy and the efficacy of interventions it will interrogate a large collection of cohorts with multiple biological medical clinical sociodemographic and environmental and lifestyle data to identify the most robust risk factors triggering depressive symptoms but also moderators of the riskby putting together unique human samples of placenta chorionic villi and amniotic fluid and animal models happymums will improve the understanding of the neurobiological mechanisms affected by depressive symptoms in pregnancy that lead to alterations in the foetal environment shaping offspring risk for developing negative mental outcomes the use of three complimentary rodent models will allow to achieve a proof of causality and the presence of an innovative fish model will elucidate the mechanisms specific to placenta by which adverse maternal conditions are transmitted to the offspring without the potentially confounding mitigating effects of compensatory postnatal maternal care this knowledge will allow the identification of new targets for the development of novel medications for the repurposing of existing medications or for the development of nonpharmacological interventions happymums will also develop a digital platform where ai toolsbased data can be collected together with biological clinical medical environmental and lifestyle data through a mobile phone app that will be at the interface with clinicians via a dedicated dashboard this will allow early screening of depressive symptoms prompt diagnoses personalized treatments and the promotion of protective lifestyle attitudes overall happymums will not only increase the knowledge in the field of mental disorders in pregnancy but also improve the wellbeing of these women providing unprecedented benefits also to the offspring and thus to society at large
molecular storage system moss intelligent dna data storage

molecular storage system moss intelligent dna data storageseveral groups including helixworks have demonstrated dna storage systems over the last few years the information stored has steadily increased from a few kilobytes to several hundred megabytes however current dna synthesis techniques based on phosphonamidite chemistry are designed for manufacturing errorfree dna for biological applications today synthetic dna costs 0001 per nucleotide making dna storage seven orders of magnitude more expensive than tapebased on results generated from the fet open project oligoarchive grant agreement 863320 three of the participants helixworks technologies limited imperial college of science technology and medicine and eurecom are seeking to take the oligoarchive results further through the development of moss a new dna storage system based on a novel enzymatic technique for writing dna at scale this innovation was assessed by the jrcs market creation potential indicator framework as having a high level of market creation potentialin moss we will investigate novel enzymatic synthesis techniques that can dramatically reduce cost of dna synthesis by exploiting that using dna as a data storage medium does not require precise errorfree synthesis our consortium members are at the forefront in both academic research imperial eurecom in structural biology especially dnabinding proteins synthetic biology and automation including cellfree protein synthesis and industrial research helixworks in pursuing novel scalable enzymatic synthesis techniques that can offer lowcost highthroughput write path to dna storage
unveiling the molecular coordination between the cell division machinery and slayer biogenesis in bacillus anthracis

many bacteria possess a paracrystaline protein coat named the slayer slayers cover the entire cell surface and are involved in protection virulence cellshape maintenance and communication lattice integrity is essential for slayer function meaning that its assembly must be intimately coordinated with cell growth and division some studies have reported that slayer biogenesis colocalizes with peptidoglycan pg synthesis however the underlying molecular mechanisms remain unknown here i will investigate the molecular regulatory network that orchestrates slayer assembly cell division and pg synthesis in the human pathogen bacillus anthracis where slayer defects render the bacterium avirulent making this ultrastructure an attractive therapeutic targetin the slydiv project i will 1 structurally and functionally compare sap and ea1 the exponential and stationary phase slayer proteins of b anthracis 2 follow their in vivo assembly using timeresolved labelling and fluorescent microscopy and 3 uncovering the molecular interactions that couple slayer assembly with the pg andor cell division machinery i will make use of chemicals that selectively target the cell cycle or cell division and monitor localization of slayer assembly will use nanobodies that disturb slayer integrity and monitor the localization of cell wall synthesis and use my interactomics experience to discover contact partners of slayer and pg synthesis thus slydiv is a multidisciplinary and integrative project that combines structural biology biophysics cell imaging and microbiology in addition slydiv meets my solid knowledge on bacterial cell division with the host labs expertise on slayer structure and function the slydiv project aims to lead to a major breakthrough in the basic understanding of the regulation of the bacterial cell envelope while it will pave the way for specific novel molecular therapies against b anthracis a category a bioterrorist agent
in diversity we trust preserving and promoting the literary heritage of chinese minorities

initiatives geared at promoting heritage as a tool for the continual revalorization of cultural diversity have spread like fire in recent decades who determines what counts as heritage however has been contested on the global sphere the unesco holds a monopoly by controlling inclusion to the lists of world heritage and intangible cultural heritage espousing the unesco designations china has in parallel developed an internal framework for the study and the dissemination of cultural heritage some scholars have criticized chinas cooption of the unesco discourse for nationbuilding yet scholarship in critical heritage studies concurs that heritage value is not inherent in cultural items themselves but rather in how such items are used to assert and affirm certain sets of values dive explores how chinese authorities have mobilized the origin myths chuangshi shenhua of the 55 officially recognized chinese minorities shaoshu minzu to sustain the discourse of china as a united multicultural nation these myths have been circulated via literary publications documentariesbroadcasts and websites to analyze the information from these heterogeneous sources dive employs a crossdisciplinary approach that draws from the candidates research experience in digital humanities and in literary media and minority studies exploring the authorized discourse on minorities myths this action contributes to decentralizing chinese literary studies traditionally focused on the han majority and to heritage studies by providing the first indepth research on minority heritages appropriation in a socialist context research outputs will strengthen the candidates academic profile as an expert on chinese textual heritage opening career opportunities in and beyond academia moreover the study of heritage in a multicultural nation such as china prepares the candidate to provide comparative insights to heritage practitioners and policy makers in the european union
climate inequality and democratic action the force of political emotions

cidape is a groundbreaking project at the forefront of research on the complex interplay between citizen engagement climate change and social and economic inequalities at its core lies the recognition that emotions play a fundamental role in political participation and communication understanding and responding to citizens emotional reactions as set up by cidapes inquiry are essential to achieving coordinated democratic actionwith a focus on the perceived and articulated emotions around climate and inequality cidape proposes a comprehensive multimethods approach and multidisciplinary analysis of the force of political emotions in european politics of climate change the projects wps delve into emotions in the political sphere media everyday life globallocal entanglements social movements and citizen engagement showing how emotions shape peoples rational argumentation engagement and ultimately who and what they care aboutcidape seeks to uncover the core mechanisms and processes at the heart of political action at the policy polity and politics levels and proposes participatory tools policy instruments and methodological guides to address these challenges the project emphasizes that the climate crisis provides a unique opportunity to unite citizens across the political spectrum and that the success of coordinated democratic action will require high levels of public trust strong institutions and policies that resonate with citizens political emotions the consortium assembles experienced researchers from political science sociology linguistics communication science and international relations and distinguished representatives from civil society across nine european countries it has a strong dissemination strategy aiming at diverse citizen groups at local national and supranational levels of democratic engagement