Dragon09/odtu_chatbot huggingface dataset:
nonco2 forcers and their climate weather air quality and health impacts

indicated area bwhile overall the global warming with the causes and global processes connected to well mixed greenhouse gases ghgs especially co2 and their impacts on global to continental scales are well understood with a high level of confidence there are knowledge gaps concerning the impact of many nonco2 radiative forcers leading to low confidence in the conclusions this relates mainly to specific anthropogenic and natural precursor emissions of shortlived ghgs and aerosols and their precursors these gaps and uncertainties also exist in their subsequent effects on atmospheric chemistry and climate through direct emissions dependent on changes in eg agriculture production and technologies based on scenarios for future development as well as feedbacks of global warming on emissions eg permafrost thaw in addition to the atmospheric radiative forcing gaseous or aerosols albedo changes connected to landuse and landcover can play a role depending on the adaptation or mitigation measures included in different scenariosthus foci responds to topic d10101 area b and its main goal is to assess the impact of key radiative forcers where and how they arise the processes of their impact on the climate system to find and test an efficient implementation of these processes into global earth system models esms and into regional climate models rcms and finally to use the tools developed to investigate mitigation andor adaptation policies incorporated in selected scenarios of future development targetted at europe and other regions of the world we will develop new regionally tuned scenarios based on improved emissions to assess the effects of nonco2 forcers mutual interactions of the results and climate services producers and other endusers will provide feedbacks for the specific scenarios preparation and potential application to support the decision making including climate policy
dissecting brain pollutant exposure and its contribution to neurodegeneration and alzheimers disease from signatures to prevention strategies to protect and maintain a healthy brain

human populations are impregnated by various types of chemical pollutants reported as hazardous waste present in the environment certain pollutants have adverse effects on brain but the underlying mechanisms and timewindow exposures are still unknown as well as their contribution on dementia the 7th leading cause of death exposignalz project aims to delineate the impact of a selection of environmental pollutants on brain health throughout life and their role in dementia especially alzheimers disease ad representing about 70 of dementia cases through interdisciplinary approaches integrating experimental and epidemiological studies our objectives are to 1 identify environmental pollutants likely to have neurotoxic effects and proamyloidogenic properties predictive of a neurodegenerative trajectory related to ad using in vitro screening models 2 characterize pollutant signatures associated with brain aging and ad in biological matrices of 4 european populationbased cohorts of various age groups 3 understand the mechanisms of action of pollutants identified in the in vitro screenings and those found in biological signatures using adipsc and ad preclinical models 4 explore the impact of pollutants on early neurodevelopment as a factor of susceptibility for later neurodegenerative diseases using brain organoids and gestational contamination models and 5 disseminate knowledge to policy makers to the relevant stakeholders and general public in order to define guidelines for disease prevention and take actions for populations health the project which aims to identify chemical pollutants as new risk factors for dementia as well as new pollutantassociated biomarkers could contribute to i reduce or delay the incidence of ad and thus reduce the economic and social burden and ii allow an earlier diagnosis of ad combined with new disease modifying treatments to delay the entrance of patients in the more severe stages of the pathology
n6 methyladenosine rna modification in acute coronary syndrome

the main aim of the maacs project is to explore if specific changes in epitranscriptomic landscape of peripheral blood mononuclear cells pbmcs particularly n6methyladenosine m6a rna modification could be used as a biomarker for acute coronary syndrome acs differential diagnosis and prediction of future adverse outcomes this project will be the first to 1 identify acsspecific m6a biosignatures in pbmcs using direct rna nanopore sequencing 2 quantify total m6a rna modifications in pbmcs of acs and stable angina patients using lcms 3 assess the clinical utility of total m6a rna modification in pbmcs and 4 perform an in vitro functional analysis of acsspecific m6a modifications the realization of set objectives will reveal novel mechanisms implicated in the aggravation of acs that could lead to the development of novel tools for personalized prevention diagnosis and treatment in order to utilize the power of the integrative and multidisciplinary approach this project will establish collaboration between dr miron sopic msca pf applicant and toptier institutions cardiovascular research unitluxembourg institute of health beneficiary led by dr yvan devaux the projects supervisor mcgill university in quebec associated partner for secondment and university of luxembourg associated partner working in the international environment with eminent experts and a productive team of researchers and using stateoftheart infrastructure and techniques will secure the applicant to become an internationally recognized expert in the epitranscriptomic field and an independent researcher with strong credibility competent to establish and lead his research group maacs contributes to sustainable development by complying with several objectives good health and wellbeing quality education gender equality in research reduced inequalities and partnership for the goals
twinning excellence in management and research for green energy and chemicals using singleatom catalysis

our reliance on depleting fossil fuel reserves for energy carbon feedstock and chemicals poses significant threats to both our energy security and the environment in response there is a growing interest in seeking alternative ecofriendly and sustainable resources thus international agreements and sustainable development goals set by the european union and united nations underscore the urgent need for a transition to a fossil fuelindependent and diversified carbon and energy economy the merge project is dedicated to the valorisation of renewable carbon feedstocks that do not compete with food and land resourcessuch as waste lignocellulose biomass derivatives this valorisation is achieved through electro or photocatalytic reforming processes resulting in the production of industrially essential chemicals and fuels to address this challenge merge project is focused on the development of environmentally friendly recyclable lowcost and efficient cooperative and tailored singleatom catalysts this endeavour leverages knowledge transfer between the research unit in czechia and the topclass partners of the consortium the ultimate goal of merge project is to cultivate a culture of excellence in research strategy management and technology transfer to the wideningcountry partner at the same time merge will position the wideningcountry partner and all twinning partners as prominent contributors in the european landscape in the field of advanced and sustainable catalysts for green and technologically important chemicals via a committed and deep alliance towards excellence permeating all facets of research
multibeam integrated optical antenna array design for freespace communication

humanity envisions the future world with cars driving themselves the holograms in video conferences augmented reality used everywhere to assist our daily life and the list continues the previous generation of mobile networks could not support such applications and so the redesign of the network was decided with the 5th generation 5g network standardization in the redesigned network topology the signal processing previously occurred on the antenna site was moved to a central location and virtualized this disaggregation allowed advanced functionalities and reduce the cost of antenna sites on the other hand it generated the need for a very fast and low latency connection between these disaggregated units fronthaul which cannot be supported with current wireless technologies and so only the fiber can be used the mimosa aims to combine concepts from the rf world with integrated photonics for producing and demonstrating a compact electronically reconfigurable optical mimo radiating system the multibeam feeding network and the radiating elements antennas will be designed as a single monolithic photonic chip which will reduce significantly the cost and form factor of the system a system with at least 8 controllable beams will be designed with the researchers background lying in the field of rf and wireless communications his close collaboration with a host institute with strong expertise in the field of photonics provides the optimal framework for translating wireless needs into opticallyenabled realities such a multibeam steerable mimo system is expected to offer high availability links operating in reallife atmospheric conditions offering capacities higher than 50gbps for up to 1000m link distance the project will generate a framework for the implementation of high data rate optical wireless links capable to support 5g and beyond fronthaul requirements while reducing the cost mass form factor and power consumption of the links
dynamic engineered heart tissue to study interindividual susceptibily and improve treatment of heart failure

the objective of dissecthf is to generate engineered heart tissue eht with the use of human induced pluripotent stem cells hipsc from specific forms of heart failure hf it focusses on three etiologies of hf with a clear trigger and a large interindividual susceptibility pregnancy induced hf anthracycline cardiotoxicity and pln cardiomyopathy to unravel common pathophysiological mechanisms involved in the development of hf the rationale is better understanding of molecular pathways leading to hf and knowledge about interindividual susceptibility is needed to improve treatment for detection of changes on a molecular level cardiac tissue is needed using innovative experimental approaches such as dynamic loaded eht dyneht patient specific cells unbiased target finding and deep phenotyping i will dissect common disease pathways in the development of hf specific objectives 1 construction of dyneht from patient specific hipsc derived cardiomyocytes endothelial cells and fibroblasts 2 generation and deepphenotyping of dyneht from a females with pregnancy induced hf susceptible and siblings with a normal pregnancy resilience b cancer patients with severe hf after anthracyclines susceptibility and patients who could resist high dose anthracyclines resilience c patients with an early pln cardiomyopathy phenotype susceptible versus elderly asymptomatic pln mutation carriers resilience 3 identify overlapping and diverse factors 4 validate discoveries and apply in unique human cohorts with data on incident hf workpackages wp1 optimize construction of dyneht from patient specific hipsc wp2 phenotyping of dyneht from the three hf etiologies focussing on susceptibility and resilience wp3 explore the transcriptome and proteome and apply a systems biology approach wp4 validate results and explore human relevance in a large cohort with unique phenotyping
tibetan obsolete mortuary practices and afterlife beliefs language conservatism of religious writings in the service of protobodish reconstruction

tomb tibetan obsolete mortuary practices and afterlife beliefs language conservatism of religious writings in the service of protobodish reconstruction aims to yield a range of new contributions to our understanding of the old tibetan language and funerary practices on the tibetan plateau by investigating ancient records concerned with nonbuddhist funerary rituals in addition the project will uncover important linguistic links to other regional language communities and will establish the first testable hypotheses about the genetic relationship of tibetan languages the synchronic perspective of the philological study will be complemented with historicolinguistic analysis tomb will specifically focus on translating documents from the old tibetan funerary corpus that have never been translated before these manuscripts are remarkable for several reasons 1 they provide insights into funerary rituals that did not survive beyond the tibetan empire 2 they reflect elements of ritual culture shared with other nontibetan speaking groups in the region 3 they offer evidence of earlier prehistorical stages of the tibetan language and 4 they give us an opportunity to enhance our understanding of tibetan languages and to uncover their genetic links to related languages through a comprehensive analysis of the corpus from both historical and textlinguistic perspectives we will gain insights into archaisms that can be identified as features of prehistorical tibetan this foundational work will set the stage for reconstructing prototibetan identifying and describing these features will in turn contribute to the reconstruction of protobodish the presumed ancestral language of tibetan eastbodish and tamangic languages the innovative approach to ritual textual sources as reservoirs of prehistorical linguistic forms tackles thus far unexplored fields of research and promises to enrich our understanding of the tibetan nonbuddhist religious culture
full european hdi pcb and assembly supply chain for space and industrial segments

focusing is a powerful playground in which outstanding worldwide recognized european companies with complementary expertise and stateoftheart facilities will share and merge their experience with the ultimate goal of exploring and exploiting novel greenoriented routes towards the significant upgrading of the current printed circuit board pcb and surface mount technology smt and the enhancement of the overall european competitiveness even though space market is addressed in priority other applications may be addressedthe growing trend towards miniaturization and the demand of ever more compact and integrated devices have led to an ever increasing interest in printed circuit board with embedded components and in hdi boards both for the multiple potentialities of a technicalproductive nature and for the encouraging growth prospects of the market demanddespite improved manufacturing hdi technologies have been widely demonstrated and exploited eg for automotive biomedical and commercial applications incorporating these improvements in capability with space reliability requirements still representing a challengein this project hdi technology is considered pivotal for the integration of cuttingedge electronic solutions able to revolutionize the design of present and future products eg from standard sized to micro and nano satellites by reducing the payload and boosting the performances of the space equipmentthe objective of the proposed activity is double to develop and validate stateoftheart building blocks to demonstrate the reliability of the technologies and processes developed to build a fully european competitive sustainable and independent supply chain based on stateoftheart laminates and cuttingedge hdi pcb manufacturing technology focused on advanced space applications but potentially benefiting as well to other applications
genetics across the lifespan unraveling agespecific determinants of severe mental illness

mental disorders affect 1 in every 8 people in the world right now genetic predisposition plays a crucial role in the development of severe mental disorders genomewide association studies gwas revolutionized the field of psychiatric genomics by identifying the individual effects of millions of common genetic variants on behavioral cognitive and clinical traits however current gwas provide a static snapshot of genetic influences and thus misses the rich tapestry of genetic effects that unfold across an individuals lifespan funded by the marie skodowskacurie actions program the genlife project aims to uncover novel genetic variants with agedependent effects that have remained hidden until now revealing agespecific determinants of severe mental illness across the lifespan will promote the development of more effective biologybased prediction tools tailored to individuals disease trajectories by providing timely support and intervention mental health professionals will be able to identify and address emerging mental health issues before they escalate into more severe conditions the genlife project is based on the synergy between the applicants highly interdisciplinary profile cuttingedge research at the host institution and unique nordic resources it will be completed at worldleading research institutions the university of oslo and the norwegian centre for mental disorders research norment under the supervision of prof ole a andreassen expanding the applicants line of research academic maturity and professional networks will enhance the development of his career as an independent researcher
selfpowered nearinfrared photodetectors for wearable healthcare devices

wearable healthcare devices have disrupted health monitoring with personalized medical diagnostics and realtime data collection an essential component of such devices are highperformance nearinfrared nir photodetectors which facilitate the noninvasive measurement of vital signs and physiological parameters such as blood oxygenation heart rate and pulse rate significant progress has been made in exploring functional materials for selfpowered nir photodetectors on rigid substrates however the development of flexible selfpowered nir photodetectors and their integration into wearable device applications are largely overlooked in the literature in spinip we aim to develop efficient and stable flexible nir photodetectors operating in selfpowered mode or zero bias based on nontoxic and costeffective semiconductors tailored for seamless integration into wearable healthcare devices in particular we will leverage ecofriendly tinbased perovskiteinspired materials pims starting from a2sni6 owing to their broadband photodetection from uvvisiblenir regions good air stability and lowtemperature solution processing the mechanical flexibility of photodetectors is a paramount feature enabling seamless adherence to various surfaces and conforming to the dynamic movements of the human body the mechanical flexibility of the device will be investigated via insitu nanoindentation in fesem to ensure flexibility we will perform thorough composition engineering of photoactive pims films and explore the synergetic effects of polymer scaffolds and hybrid annealing the performance of nir photodetectors will be enhanced by understanding the defect chemistry of pims the charge transport within the device components and the device physics the reliability of the photodetectors will be verified in different conditions environmental thermal and mechanical and will be improved by reducing the ion migration and device engineering approaches
bringing health and social sciences to a new level through an interdisciplinary doctoral programme

it is widely recognised that nonmedical determinants of health play a major role in health many of these determinants fall within the scope of social sciences and humanities ssh world health organisation estimates that social determinants of health housing and working conditions social inequalities education etc account for between 3055 of health outcomes today there are urgent needs of profiles capable of understanding the issues in their entirety rather than through a strictly health or social point of view breath program will fill that gap by training excellent researchers breath aims to be the next interdisciplinary doctoral program in health and ssh offering 20 doctoral positions for 3 years each at one of the 3 paysdelaloire universities in france led by distinguished supervisors through an open and meritbased recruitment procedure it will provide excellent opportunities for international intersectoral and interdisciplinary research and training under attractive working conditions breath is coordinated by the university of angers with the universities of nantes and le mans as implementing partners the 3 public universities have longstanding habits of strong collaboration in doctoral studies already managed jointly by the doctoral college with 83 research groups including 49 in health and ssh breath will also rely on a 27 associated partners network that will strongly enhance the opportunities of the doctoral candidates dcs dcs will come closer to the private sector by collaborating with medical and healthcare organisations during secondments or special events beyond training through their own research they will benefit from training courses in research techniques complementary workshops for transferable skills scientific meetings and conferences and the access to international scientific networks with the final aim to promote knowledge exchange and mobility among academic and non academic partners
exploring consumer behavior in the digital age insights from theorydriven largescale randomized field experiments on mobile data alerts and data breach announcements

dale addresses an urgent need to advance research on consumer behavior namely consumers responses to the timing of mobile data scarcity messages and data breach announcements using a multimethod approach composed of theoretical models and largescale randomized experiments rme dale builds upon research from information systems behavioral economics operations and marketing to build more effective tools to improve consumption efficiency and mitigate the repercussions of cyberattacks first dale builds a theoretical framework of how behavioral nudges in a resource scarce setting improves consumption efficiency and shows that in contrary to conventional wisdom sending warnings as early as possible may lead to higher chances of data shortages a finding that highlights the importance of an underinvestigated aspect namely the timing of alerts based on the above the project complements the study with a rme in partnership with a leading telecommunication provider interlinked with the everincreasing data consumption needs is the problem that the very same data we leave behind may be breached the second phase investigates how consumers react to databreach announcements i build a theoretical framework of how consumer shopping behavior may change in response to such breaches and test these predictions with a fouryear granular dataset provided by a multichannel grocery partner dale will provide practical crosssectional interdisciplinary interventions for use by academia policymakers and business my training supervised at iese business school will allow me to hone new academic and nonacademic skills and fulfill my career ambitions a become a renowned researcher with toplevel influential connections to industry and public entities b position me as an interdisciplinary crosssectoral expert on consumer behavior in the digital world poised for achieving tenure track goals and decisioninfluencing leadership in nonacademic settings