Dragon09/odtu_chatbot huggingface dataset:
waveguidebased cochlear implant for optogenetic stimulation

the optical cochlear implant oci aims to restore near natural hearing in profoundly hearing impaired and deaf patients sound perception will be restored through an implantable medical device in combination with a gene therapy medicinal product thereby the auditory nerve is stimulated directly through focused light replacing the dysfunctional or absent hair cells this is achieved through combination of microscale light emitter technology and precise neural control through expression of lightgated ion channels in the auditory nerve called optogeneticshere we propose to prove feasibility of an optical waveguide modules for future optical cochlear implants building on fabricating microscaled waveguide arrays multibeam laser diode emitters we plan to couple them via microlens arrays in a compact multichannel optical module for testing the feasibility of miniaturization and integration of the optical components preclinical validation shall be performed in rodentsthe proposed waveguidebased optical module combines several aspects which makes it a candidate for later clinical application the optical emitters can be safely integrated in the hermetically sealed titanium package housing the internal oci electronics thus there is no need to directly insert the emitters in the cochlear turns which mitigates the risk of heat impact on the patient during optical stimulation furthermore emerging red light activated opsins can be addressed by readily available red laser diode technology
pan european assessment monitoring and mitigation of chemical stressors on the health of wild pollinators

wild fauna and flora are facing variable and challenging environmental disturbances one of the animal groups that is most impacted by this concerns pollinators pollinators face multiple threats but the spread of anthropogenic chemicals ie pesticides form a major potential driver of these threats wildposh is a multiactor transdisciplinary project whose overarching mission and ambition are to significantly improve the evaluation of risk to pesticide exposure of wild pollinators and enhance the sustainable health of pollinators and pollination services in europe as chemical exposure varies geographically across cropping systems inside the crop system and among pollinators we will characterise exposure by doing fieldwork in 4 countries representing the four main climatic european regions mediterranean atlantic continental and boreal climate in germany england estonia and spain we will also develop experiments in controlled conditions on different species of bees syrphid flies moths and butterflies and collect in silico data on their traits and on toxicity of pesticides with wildposh we aim to achieve the following objectives1determining the realworld agrochemical exposure profile of wild pollinators at landscape level within and among sites2using integrated and controlled laboratory and semifield experiments to characterise causal relationships between pesticides and pollinator health3building an open database on pollinator traitsdistribution and chemicals to define exposure and toxicity scenarios by developing databases on ecological traits and the spatial distribution of pollinators in relation to their potential exposure to pesticide4proposing integrated systemsbased risk assessment tools for risk assessment for wild pollinators and5driving policy and practice through interactive innovation meeting the need for monitoring tools novel and innovative screening protocols for practice and policymaker use
unite european digital health valleys

the project partners share a vision of a borderless european digital health innovation ecosystem deeply rooted in the unite regions a european ecosystem that can tackle the challenges and capture the opportunities of the demographic transitions and the emerging silver economy in full a borderless ecosystem which brings together key stakeholders from a diverse set of regions from the private sector the public sector academia and the civic society an ecosystem encouraging and enabling entrepreneurship and pushing the local startups to scale up and importantly an ecosystem that naturally facilitates and opens up new interregional european value chains the project brings together a wide and diverse group of regional and national ecosystems that reach the borders of european geographical economic cultural and care system diversities a group of regions with a complementing bundle of challenges and aspirations to reach assets to mobilise and barriers to overcome together it makes use and builds upon the eit digital strategic innovation agenda for digital wellbeing which is directly aligned and supports the regions ris3 and longterm strategies serving as the basis for the unite cofunding commitments and joint activities plan the partners vision to unite the open borderless regionallyanchored european digital health innovation ecosystem calls for an united intervention that connects the fragmented value chains dispersed ecosystems and pockets of excellence and regional specialisation ambitions fosters the colearning between the ecosystems and enables growing together creates strategic and tactical examples of interregional value chains and digital solutions and elevates the nexus of strategies between the regional ecosystems and the global digital health networks and opportunities in longterm
asymptotic analysis of repulsive point processes and integrable equations

the purpose of this project is to apply and develop robust mathematical methods for solving asymptotic problems on repulsive point processes and partial differential equations the point processes considered will mostly be taken from the theory of random matrices such as the eigenvalues of random normal matrices but we will also consider discrete point processes with a more combinatorial structure such as lozenge tilings of a hexagon these models are used in neural networks multivariate statistics nuclear physics and number theory and therefore have been widely discussed in the physics and mathematics literature we will investigate asymptotic properties of such processes as the number of points or eigenvalues or lozenges gets large all the point processes considered have in common an interesting feature they are repulsive in the sense that neighbouring points repel each other however in other aspects these processes are very different from one another and some of them require completely novel techniques for example the tiling models are related to nonhermitian matrixvalued orthogonal polynomials and twodimensional point processes are out of reach of standard methods when the rotationinvariance is broken an important part of the project is to develop novel techniques to analyse these point processesthe last part of the project focuses on integrable partial differential equations the objective is to develop a new approach for solving longstanding problems with timeperiodic boundary conditions one of the main tools we will use is the deiftzhou steepest descent method for riemannhilbert rh problems by solving new problems using this approach this project will contribute to the development of the method itself since the range of applicability of rh methods is very broad these new techniques are likely to have an impact on a wide spectrum of scientific questions
creating and managing a pipeline of h2020 projects for the innovation fund on ccus

carbon capture use and storage ccus has been recently recognised as a key technology to reduce carbon emissions especially in hardtoabate sectors and significantly contribute to eu carbon neutrality targets for 2030 and 2050 accelerating the upscaling and subsequent market introduction of ccus research results and technologies is becoming thus increasingly urgent the horizon 2020 programme h2020 has contributed to the development of innovative technologies including ccus the innovation fund programme if on the other hand focuses on commercial demonstration of innovative lowcarbon technologies the transition from mature h2020 projects to the if is a logical pipeline along the trl line synergies between these and other eu funding programmes can contribute substantially to overcome the hurdles and derisk large scale investments in firstofakind ccus flagship projects but still much remains to be done in accelerating gotomarket strategies for publicly funded innovations leads aims at bridging the gap from research to deployment for ccus projects in europe by building an innovation pipeline of promising h2020heu projects and supporting project owners to overcome the main bottlenecks and reach final investment decision building on their outstanding experience in innovation and eu programmes as well as leveraging on their strong eu networks leads partners will implement a welldesigned methodology and set of measures to assess and select the most promising h2020 projects coach them and enable them to apply to if leads methodology will be tested with six h2020 ccus project cases a set of reusable if tools will be created and made available to ccus stakeholders synergy mechanisms between h2020 and if will be also created by aligning the ccus upscaling potential with if targets at leads project end at least three h2020 projects are expected to have completed the full leads cycle and have submitted a full if application
posture and bodily movements in the bible and biblical religions

postures and movements are relevant for both a linguistic and a socioanthropological investigation from a crosslinguistic perspective verbs of posture and motion show several interesting idiomatic and metaphorical usages and can be employed to express abstract concepts eg psychological states and grammatical aspects eg urgency or gradual progression of an action from a socioanthropological perspective posture and body language can express real or assumed power relationships and hierarchies and serve as externalizers of status gender age and physical weakness they establish express and maintain group identity and they indicate friendship and respect or on the contrary hostility and selfprotection posture investigates the theme of bodily attitudes postures and movements within one of the most important pieces of cultural heritage the old testament ot furthermore it also investigates the reception of biblical postures and motions within cultural and intellectual products that depend on the ot either directly or indirectly ie ancient translations aramaic syriac greek and latin and late antique jewish and christian exegesis 1st3rd c cedescriptions of bodily postures and motions are very recurrent in the ot both literally and metaphorically however as of today not enough attention has been paid to this topic combining the semantic analysis of posture and motion verbs with their anthropological and social implications will allow to gain new knowledge about the idea of body in the ot moreover the analysis of reception in early exegetical jewish and christian contexts will shed some light on the development of the meaning of body and bodily attitudes through centuries of translations and theological interpretations from ancient times to present days
using kleptoplasty to illuminate the evolution of plastids and the order of steps during endosymbiosis

plastids the photosynthetic organelles of eukaryotes arose via endosymbiosis of cyanobacteria by a eukaryotic host and were subsequently spread across eukaryotic diversity by additional endosymbioses these events greatly impacted the evolution of eukaryotes introducing a novel lifestyle and shaping their diversity yet we still know very little about the steps taking place during plastid endosymbiosis the traditional view considers this a straightforward uptake and retention of the symbiont that later becomes the plastid followed by genetic integration recently profoundly different models proposing several transient interactions with a variety of endosymbionts that transfer genes to the host before fixation of the final endosymbiont have gained traction kleptoplastidic species lineages that transiently retain and use plastids from their prey are at the centre of this paradigm shift providing the first insights into the order of steps during plastid endosymbiosis kleptoplasty is rare primarily found in a group of microbial eukaryotes and the few kleptoplastidic taxa known have not been studied in the context of endosymbiosis i propose here to resolve the process of plastid endosymbiosis using kleptoplasty as a unique model by addressing these questions 1 what is the hidden diversity of kleptoplastidic taxa 2 what is the level of genetic integration in these taxa 3 what is the composition of the plastid proteome in a kleptoplastidic lineage 4 how does the kleptoplast and control of the kleptoplast change during integration to answer these questions i will combine a novel imagingbased screen for kleptoplastidic lineages with highthroughput transcriptomics and phylogenetics and provide the first plastid proteome of a kleptoplastidic lineage this project will not only advance our shifting understanding of endosymbiosis but the methods developed will provide a foundation for future studies on the evolution of microbial eukaryotes
innovative nasal vaccines to prevent pathogen colonization and infection in the upper respiratory tract

bacterial and viral respiratory infections are a leading cause of morbidity and mortality worldwide streptococcus pneumoniae and bordetella pertussis influenza virus and sarscov2 are responsible for diseases with major public health impact communityacquired pneumonia whooping cough influenza and covid19 respectively vaccines against some of these diseases administered by intramuscular or subcutaneous injection do not prevent colonization or infection of the upper respiratory tract urt and therefore have limited impact on pathogen transmissionthe nosevac consortium aims to develop and assess innovative nasal vaccine platforms as a novel concept to block the earliest stage of infection thereby inhibiting urt colonisation transmission and disease the project builds on a unique consortium of 12 renowned and complementary teams from the eu uk and switzerlandnosevacs objectives are todevelop vaccine formulations for nasal delivery of rna and proteinbased antigensdiscover bacterial antigens that promote colonization of the urtuse a combination of in vitro and in vivo models for optimal evaluation of vaccines efficacyidentify key host immune factors required for longterm protection of the urt in human deliver two nasal vaccine candidates to fight s pneumoniae and b pertussis infection and a single bivalent vaccine to prevent influenza and covid19address acceptability of nasal vaccinationexpected outcomes include 1 strengthening innovation in europe by enriching the pipeline for novel vaccines against new respiratory infections 2 increasing knowledge on the mechanisms underlying urt colonization infection and immunity and 3 evaluating nasal vaccine acceptability by stakeholders nosevac will develop strategic research avenues to fight respiratory pathogens including those with epidemic potential and will facilitate evidencebased decision making to policy makers and investors
development of an enhanced laser beam technology based on a new optical system for industrial laser processing applications

although inkjet marking systems are widely used for marking the products factors such as high running costs and low quality of marks are preventing their 100 adoption the toxicity of inks in addition makes them harmful for the land water ecosystems further these systems spill tiny droplets of ink while printing resulting in lower resolution as compared to laser printed coding however conventional laser systems cannot solve all the inkjet marking drawbacks mainly due to their lower marking speed inphocal has developed the worlds first optical system that can be integrated with laser marking systems to increase the focus range of the original laser beam up to 400 times the laser marking machine integrated with inphocal technology will provide advantages such as high marking resolution higher production rate and printability on curved surfaces in the eic project inphocal team plans to miniaturize the device conduct pilot trials followed by business development
proto advanced personalized therapies for osteoarthritis tackling inflammation to improve patient outcomes

osteoarthritis oa is the most common form of arthritis worldwide chronic lowgrade inflammation in the articular environment causes cartilage degeneration at an early disease stage resulting in chronic pain disability and loss of independence due to progressive joint destruction to date no treatment is available to sustainably combat lowgrade inflammation in earlystage oa patients biomechanical causes for intraarticular inflammation and oa development have been detected in specific patient groups the proto consortium strives to implement new evidence and patientcentred treatment strategies for early and predisease stages for the first time earlystage knee oa patients will be treated with local plxpad injections a novel allogeneic cell therapy product with distinct antiinflammatory capacities that may halt or revert disease progression secondly patients recovering from anterior cruciate ligament reconstructions with pathological gait patterns leading to knee oa will be treated with a personalized sensorbased digital training intervention we intend to prevent health to disease transition by restoring physiological movement and reducing joint inflammationto assess treatment success in early and prestage oa proto gathers scientific and clinical specialists who have genuinely shaped clinical radiological and biomarker outcome parameters for oa in recent years this will be the first time that these renowned experts join forces to analyze stratify and compare fundamentally novel disease modifying treatment strategies for oa in one consortium proto was developed with the help of patient organizations industry partners and research societiesrestoring physiological joint homeostasis at an early disease stage may be the key to understanding health to disease progression in oa targeting this window of opportunity will fundamentally change the way oa is treated today and in the future
louis the smart earplug for industry made in france

safehear has designed louis a new earplug for industrial and noisy environments our mission is to prevent diseases and accident cause of a lack of communication in industry safehear is a french startup of 8 people we work on senses improvement solutions using embedded intelligence partners st microelectronics inria bpi france efi automotive axandus
all in one harvesting of waste heat with solid thermal battery

thermal batteries are devices that convert thermal energy without the need for a spatial temperature gradient giving them anenormous potential advantage over competing methods despite its promise thermal batteries are yet not suitable for practicalapplication as they were demonstrated only with liquid electrolytes which severely restricts the operation temperature range tot50 k and an electrochemical stability window to pair with thermodynamically efficient electrodes the goal is to develop acompletely new paradigm towards allsolidstate thermal battery thermal cell which is based on reversible changes of the materialselectrochemical properties and on h transport operating on recovered waste heat over an unusual wide range of temperatures ofambient to 300c we envision the solid thermal battery to charge at a defined low and high constant temperature due to phasechanges and h intercalation taking place at the electrodes fundamentally we contribute to a new thermal battery concept suggestmaterials to translate the proposed chemistryatwork and give a proofofconcept to gain first electrochemical performance insightsdefining thin film device architectures collectively the here proposed solid thermal battery closes the everexisting gap betweenthermoelectric and liquid based thermal batteries through widening of the thermal operation window to capture waste heat anddefining a new set of h solid conductors and interfaces suited for energy storage the fundamentals derived on electrochemicalinterfaces and h conductor films such as ceriabased metal hydride binary oxide and possibly high entropy alloys for electrolytesand electrodes contribute in their design and careful discussion of electrothermochemistry thermodynamics and kinetics toengineering design principles of the here proposed fully solid thermal batteries for energy harvesting putting waste heat to workwith perspective for industry translation
engineering spinsplitting in atomically thin 2d noncentrosymmetric crystals

the information technology and communication sector ict has been undergoing remarkable progress fuelled by integrational advancements in its building blocks the field effect transistor fet the fets in commercials microprocessors still use more than half a century old energyintensive conductance switching processes to perform logic operations it is well understood that the inability to remove the dissipated energy in such switching process will eventually stop the ongoing downscaling of the microprocessors in the next few years spintronicbased devices working by virtue of energy efficient switching the spinpolarization are considered to bring a paradigm shift in logic operations such devices use chargetospin interconversion csi which is maximized in materials with strong spinorbit coupling soc the main goal of access is to engineer inversion symmetry and soc in vertical heterostructures of twodimensional layered materials 2dlms to facilitate the csi process we shall fabricate dual gated hbn encapsulated fets using the 1t phase of transitional metal dichalcogenides and its twisted bilayers to tune symmetry and soc access will exploit the edelstein effect and intrinsic berry curvature dipole to generate currentinduced magnetization and detect it via unidirectional magnetoresistance umr and nonlinear hall effect nhe measurements the csi in our samples will be further tuned by dynamically varying vertical displacement field and the charge carrier density in the channel by this way access will harness the topological properties of 2dlms for applications in future spintronics devices capable of magnetfree spintocharge interconversion besides its scientific goals access also focuses on strengthening the researchers transferable skills and providing him a highquality interdisciplinary research training helping him to build a promising scientific research career
a meta operating system for brokering hyperdistributed applications on cloud computing continuums

nebulous will accomplish substantial research contributions in the realms of cloud and fog computing brokerage by introducing advanced methods and tools for enabling secure and optimal application provisioning and reconfiguration over the cloud computing continuum nebulous will develop a novel meta operating system and platform for enabling transient fog brokerage ecosystems that seamlessly exploit edge and fog nodes in conjunction with multicloud resources to cope with the requirements posed by low latency applications the envisaged bronco solution includes the following main directions of work idevelopment of appropriate modelling methods and tools for describing the cloud computing continuum application requirements and data streams these methods and tools will be used for assuring the qos of the provisioned brokered services iiefficient comparison of available offerings using appropriate multicriteria decisionmaking methods that are able to consider all dimensions of consumer requirements iiiintelligent applications workflows and data streams management in the cloud computing continuumivaddressing in a unified manner the security aspects emerging in of transient cloud computing continuums eg access control secure network overlay etc vconducting and monitoring smart contractsbased service level agreements