Dragon09/odtu_chatbot huggingface dataset:
quantum optical multidimensional networks

quantum internet will allow unprecedented applications that will dramatically change our lives spanning from quantum secured communications to distributed quantum simulations ie ultraprecise clock synchronisation quantum secured identification efficient distribution of data and energy quantum sensors and secure access to quantum devices in the cloud the main technical limitations currently restricting the range of applicability of the quantum internet are the intrinsic ratedistance limit and the extremely difficult coexistence with the present classical telecommunication infrastructure present quantum communication systems mainly use a twodimensional encoding scheme qubit as information unit which is very fragile and susceptible to external noise in fact due to decoherence processes caused by the interaction with the external environment the ability of the adopted qubits to remain in superposition andor in an entangled state is severely jeopardised on the contrary by adopting multidimensional quantum states qudit which are by nature more robust to noise owing to their higher information efficiency the potential to realise the quantum internet is within our grasp qomune intends to build and test the constituents for a quantum internet based on multidimensional quantum states by combining new technological advances with unconventional quantum interference qomune envisages a novel scheme for the generation transmission and interference of qudits which are fundamental actions of a quantum network photonic integrated quantum sources combined with multicore deployed fibres and pioneering design of efficient and scalable multidimensional quantum interference will be adopted for the realisation of qomune building blocks qomunes objectives and results will redefine the stateoftheart of quantum internet in terms of tolerance to noise in a realistic scenario and coexistence with the worldwide telecommunication infrastructure
graphenebased flexible perovskite solar cells for space applications

the gpspace project will address the use of graphenebased materials in solar cells for space applications aiming to improve the stability of device architectures against the harsh environment in space this research will evaluate the performance of graphene nanomaterials as electrodes and as interfacial layers regarding ultraviolet uv stability of metal halide perovskite solar cells under high vacuum additionally this approach will contribute to the development of lightweight solar cells architectures with high specific power epw
strongly enhanced sensitivity epr through bimodal resonators and quantumlimited amplifiers

electron paramagnetic resonance epr is a powerful tool employed across various disciplines including structural biology chemistry physics material science and many others it provides important and unique information on a local electron spin environment electronic properties and dynamics of various paramagnetic centers however a relatively low sensitivity of this method often limits the range and type of systems that can be studied thus major advancements in epr sensitivity are crucial to significantly broaden its applicability encompassing new and highly relevant systems such as single cellsthe strongly enhanced sensitivity epr through bimodal resonators and quantumlimited amplifiers strongespresso project will ignite a revolution in epr by employing sophisticated bimodal microwave resonators and intricate ways of noise reduction in tandem with novel microwave amplifiers developed for quantum technologies we will achieve this by first delivering a new generation of epr cryoprobeheads which will utilize the orthogonalfield bimodal cavities allowing to reach the sensitivity limit of these instruments secondly we will transfer the bimodal cavity concept to planar superconducting microresonators enabling the employment of these tools to study tiny pl volume samples of typical fastdecohering spin systems eg protein droplets finally we will develop an ultrasensitive epr setup based on the radiative cooling effect of the bimodal resonators and recent advances in the quantumlimited microwave amplifiers this revolutionary new setup is expected to provide a groundbreaking 5000x reduction in the epr measurement time simultaneously preserving compatibility with ordinary epr experiments and samples throughout the project we will immediately apply the developed tools to study new and intricate spin systems in the fields of catalysis protein droplets and single cells leading to major impacts far beyond epr
oru based on building blocks for advanced assembly of space systems

oruboas oru based on building blocks for on orbit advanced assembly of space systems project will develop and demonstrate an oru concept trl 6 based on the building blocks developing in previous src calls and perasperaeof objectives the main points to be developed are an oru compatible with the different si payloads and services as indicated in the topic reaching finally a trl 56 this oru to be used as plugplay module for the topic horizoncl42022space0111 in orbit demonstration phase to develop a satellite construction kit user cases for future application in isma in space manufacturing and assembly missions the oru design concept will include an appstore and openarchitecture mentality for the different modules as avionicsthe oru will be designed in a modular concept in order to be flexible and provide capabilities to upgrades in an efficient manner this project will consider the needs and requirements of current peraspera projects eross and periodthe oruboas consortium is formed by sener aeroespacial coordinator thales alenia space france thales alenia space italy isispace and dlrthis consortium has a considerable experience in previous peraspera projects sener was coordinator of og5 sirom and thales alenia space france coordinated og4 i3ds og7 eross and og12 eross rest of participants have contributed also to these and others peraspera projects pulsar mosar ade sener and isispace are currenty working in period
operationalizing relational values for a more equitable marine conservation

the global commitment to protect 30 of the oceans by 2030 faces several key challenges in preserving nature without exacerbating existing coastal resource conflicts as ocean protection is rapidly increasing to halt biodiversity loss we urgently need to understand why people value nature to better address these conflicts the revalsea project will provide a novel theoretical approach and empirical evidence to quantify predict and integrate into marine conservation the diverse ways people express why they value their relationship with nature ie relational values in coastal systems relational values rvs emerge as a keystone in conservation efforts breaking with the traditional exclusively material valuation of nature and opening a new opportunity to adopt more inclusive and socially relevant strategies for biodiversity conservation this aspect is rarely explored in marine systems even when its consideration in conservation is critical to increase equity and reduce resource conflicts addressing rvs in marine conservation policies needs overcoming several intergenerational methodological and operational challenges first it must consider the intergenerational gap between what matters for those who influence decisionmaking adults and for those who have the potential to generate socialecological changes youth second it requires the use of innovative interdisciplinary socialecological research that integrates multidimensional datasets and uses novel machine learning technology to maximise data efficiency while minimising economic costs of data collection and analysis finally it needs transdisciplinary cooperation with stakeholders and decision makers to cogenerate specific recommendations for integrating rvs in conservation policies revalsea will focus on the smallscale fishers community in spain as a case study to address all these challenges and develop a cuttingedge and globally scalable approach in other sociocultural contexts
urban simulation for air quality and heat resilience strategies

the goal of urbanair is to develop a new digital twin that supports decisionmakers in urban areas to deal with urban design dilemmas in atmospheric heat and air quality to maximise the health and socioeconomic wellbeing of its citizens affected by climate change it will provide critical tools for climate adaptation and hazard control through urban design and planning including very highresolution model components of the urban atmosphere urbanair is designed by a consortium that covers the full value chain to revolutionize digital twin platforms by starting from the perspective of the end user through cocreation with the end users and a balanced evaluation of the decision criteria the overall objective of urbanair is to yield a dynamic userfriendly infrastructure integrated into the destination earth infrastructure that empowers municipalities and industries to face urgent urban climate risksthe scales in the atmospheric models in urbanair cover the full range from the regional to the neighbourhood level this innovative multiscale approach is achieved through the development of software interfaces for the modular coupling of atmospheric models aibased emulators allow for the acceleration of these computationally expensive models which together with the application of advanced data assimilation techniques allows the quantification of risks and uncertainties for the urbanair scenarios corresponding behavioural models simulate the human response to changes in climate and associated hazards the resulting scenarios form the input to the objective evaluation of the criteria for decisionmaking with these sciencebased tools for scenario simulation of natural and human behaviour reliable risk assessment and balanced decision analysis urbanair will develop tools and the infrastructure to support decisionmakers in cities this will pave the way for effective climate adaptation by developing tools for a safer healthier and more resilient future
towards greener and more sustainable analytical approaches development of an integrative supercritical co2based multidimensional system for bioactive compound study in natural and biological samples

chemical characterization is essential to the study of bioactive compounds in natural and biological samples but conventional preparative and analytical techniques are usually time energy and solventintensive posing environmental and health risks supercritical carbon dioxide co2 present an ecofriendly alternative due to its interesting physiochemical properties prof wests research group has been developing approaches involving supercritical co2 for two decades and recently developed an integrated system combining supercritical fluid extraction sfe and supercritical fluid chromatography sfc for the online extraction and analysis of polar and nonpolar bioactive compounds from plants although feasible such coupling is very challenging especially when targeting compounds with a wide range of polarities the next step is thus to further improve the developed system and explore its applicability to other samples with different matrices and classes of compounds specifically the use of unified chromatography uc an advanced version of sfc will be investigated to further expand the efficiency and potential scope of the system since the interfacing of the two techniques is a major bottleneck preventing the system from reaching its full potential finding innovative solutions to facilitate the extract transfer from the first to the second dimension is necessary an important part of this project will thus be devoted to investigating new interface modalities to address the compatibility problems and instrumental issues pertaining to this hyphenation to boost chromatographic separation power and facilitate structural elucidation the potential of incorporating multidimensional md separation steps while coupling the system with mass spectrometry ms will also be explored to develop a novel online mdsfemdsfcucms system finally the systems utility will be demonstrated through qualitative and quantitative analyses of reallife samples
mechanism of facilitated homology search and the logic of its meiotic regulations

dna doublestrand breaks dsb repair by homologous recombination hr entails identification of an intact homologous template dna molecule in the genome homology search is guided by the dsbflanking ssdna sequence assembled into a recafamily nucleoprotein filament npf a biased version of this process regulated in an illdefined manner by chromosomes structure and meiosisspecific hr proteins also underlies homolog recognition and recombination during meiosis i in most examined eukaryotes despite its centrality for genome maintenance and sexual reproduction how homology search operates in cells and the nature of its meiotic regulations are largely unknown our goal is to solve these two major biological conundrums with a simple idea that substrate properties chromatin composition and motion provide cues for search simplification and regulationfirst we will address the existence of a homology search facilitation mechanism based on combined i dna occlusion by nucleosome and ii seeding of homology search by pioneer transcription factors wp1 these insights will be applied to accelerate yeast evolution and improve geneediting second we will address how uncoordinated movements of semirigid meiotic chromosomes can generate mechanical cues underlying hr regulations that result in patterned recombination between homologs wp2 the experimental strategy will involve extensive genetic engineering and large synthetic chromosomal regions for targeted alteration of chromatin composition chromosome physical properties and chromosome motion in cis novel genomic and molecular approaches we developed to directly detect transient hr intermediates in yeast make this project uniquely feasible this work should elucidate enigmatic interplays between chromosome biology and conserved dna metabolic processes in mitosis and meiosis broadens the current paradigm of facilitated target search by proteins in dna and yield tools of broad biotechnological interest
postdoctoral talent attraction programme to boost research career in the field of nanomaterials for biomedicine

nano4talent is an ambitious international transboundary postdoctoral programme that will award 5 postdoctoral positions of 24 months each in two calls over the programme fellows will freely define an interdisciplinary research project fitting their individual needs and interests involving two different research groups from the two different core areas nanomaterials and biomedicine and exploring new collaborations and synergies between cinbio researchers cinbio is a public multidisciplinary research centre under the umbrella of universidade de vigo uvigo focused on developing groundbreaking research in the main areas of nanomaterials and biomedicine cinbio was created in 2009 and hosts more than 170 staff members distributed in 15 different research groups that clusters chemists physicists biologists and material scientists with extensive experience in research and academic tasks the nano4talent programme represents a unique opportunity to strengthen the ties between these two areas to consolidate the positioning of cinbio as an international research centre in nanomaterials for biomedicine the cofund programme will also boost cinbios capacitybuilding by establishing synergies with the funding from regional governmentthis programme will be deeply imbued with the guidelines of the hrs4r will offer research freedom equal opportunities local careersupporting structures a wellconnected regional ecosystem of ri actors and highquality working conditionsoverall nano4talent programme provides a unique springboard to prepare postdoctoral fellows for a successful career in the european academic and private sectors aiming at decisionmaking positions this programme will also boost the interdisciplinary research at cinbio catalyse institutional capacitybuilding and cement the strategic collaboration across sectors even further
rethinking the future of clean cooling through a revolutionary class of thermallydriven chiller based on a novel biobased thermochemical material

in response to set targets for reducing our carbon footprint and securing our energy future in europe the charcool project combines the use of natural energy and naturebased solutions to achieve clean and efficient cooling charcool is an innovative and sustainable heatdriven cooling system where the excess of clean renewable energy or waste heat is stored in a modular thermochemical energy storage system that allows for seasonal storage charcool challenges the current vision of cooling industry by proposing a system that is highly flexible and reliable thanks to its coupling with a highenergy density 200 kwhm3 and inexpensive midlongterm thermochemical material the charcool chiller is supplied by a new interchangeable thus rechargeable modular thermopile made of biochar obtained from lowcost agricultural byproducts impregnated with environmentallyfriendly and easily available inorganic salts the chiller operates with water as the refrigerant offering a completely natural and safe alternative to the current electricitydriven and environmentallyharmful cooling solutions charcool runs on waste heat eg from data centres or renewable energy sources eg solar thermal or excess wind through power to heat within a temperature range of 60150 c this offers the advantage of decoupling the refrigeration system from the electricity grid thus increasing the penetration of renewable energy moreover mobile and modular thermopiles close the spatial and temporal gap between the heat source and the user cooling demand charcool clean and efficient cooling technology will reduce the volumes and cost of the current sorption systems by 40 and 50 respectively by investing in charcool europe will assert its global research and innovation leadership while creating quantifiable social and economic impacts this novel technology will partly address energy poverty and create value for the billioneuroworth heating and cooling market
literacy boost through an operational educational ecosystem of societal actors on soil health

loess will map connect and engage with multiple actors in communities of practice cops to provide an overview of the current level of soil related knowledge in different educational levels and develop teaching programmes and materials including an atlas of soil education loess will explore educational needs amongst school pupils primary and secondary levels students tertiary level and young professionals and society across the european union and horizon europe associated countries loess will investigate why existing material is not used to a greater extent and cocreate courses and modules for soil education including virtual realityaugmented reality applications these resources will target the different stages of education and connect to global and local challenges of climate change and biodiversity loss and the sustainable development goals loess will cocreate and test pedagogical techniques to encourage effective knowledge flows and discourse between educators and learners and between different knowledge systems scientific political individual local and collective cultural knowledge it will carry out activities in 15 countries and provide handson activities related to soil education through community engaged research and learning to overcome the awareness gap loess will organise focused campaigns and events to exchange knowledge promote discussion on the results and encourage higher uptake loess will also engage with public authorities and institutions responsible for primary secondary and tertiary education and provide targeted recommendations and resources for improved knowledge enhancement capacity building knowledge exchange and peertopeer learning will accompany loess education and dissemination activities
labour and ecology in an international perspective porto marghera in the phosphates archipelago

this research hosted by ca foscari university of venice in partnership with the geneva graduate institute investigates the making and unmaking of europes historical industrial areas uncovering the intersections between labour and ecological transformations from an international perspective it does so by deploying theories of extractivism to the case study of the major industrial cluster of porto marghera venice italy using the production of phosphatebased fertilisers as an entry pointporto margheras superphosphate plants were established in the 1920s in the context of rising fascism they integrated porto marghera with the green factories of expanding modern agriculture downstream and with the phosphate archipelago a network of extractive and industrial spaces on the two shores of the mediterranean upstream phosphates thus invisibly and contradictorily connected porto margheras labour mobilisations with north africas anticolonial struggles this link was also ecological as shown by the noxious health and environmental effects of phosphates the closure of porto margheras fertiliser plants in the 1990s was in fact accelerated by environmental campaigns against the dumping of phosphate waste into the adriatic sea meanwhile restructuring in the extractive areas of morocco and tunisia khouribga and gafsa respectively turned them into important points of departure for workingclass migration to italywhile deindustrial studies focus on the history of industrial areas from a local or national perspective less attention has been paid to the insertion of such industries in global hierarchies of labour and environmental degradation by analysing porto margheras place in the phosphate archipelago this research generates insights for todays ecological transitions in mining industry and agriculture at a time when fertilisers are once again in the spotlight due to concerns over sustainability and instability in food supply chains
targeted reengineering of the tumor matrix to advance immunotherapy

immunotherapy can prolong lives of cancer patient subgroups but fails in solid tumors with dense fibrotic stroma such as pancreatic cancer fibrotic stroma prevents the recruitment and activation of immune effector cells and thereby dampens the efficacy of immunotherapy mechanistically cancerassociated fibroblasts cafs initiate extracellular matrix ecm production which aggravates fibrosis by reciprocal mechanoactivation and crosstalk with tumorassociated myeloid cells forming a selfsustainable profibrotic loop however the central pathways initiating this vicious cycle and signaling compensation maintaining fibrosis under therapeutic conditions remain unclear consequently clinical solutions to disrupt this profibrotic loop are lackingi hypothesize that identifying and targeting the multistep profibrotic loop can be exploited to reengineer and normalize the perturbed ecm and increase tumor accessibility for immune effector cells and immunotherapyto disrupt the profibrotic loop i will exploit an engineered modular peptidonanobiomimetic toolbox comprising natureinspired targeting systems based on in silico design and experimental validation the peptidomimetics and nanobiomimetics will target cellular interaction mechanisms to 1 inhibit cafecm interactions driving tissue stiffening and fibrosis and 2 train tumor myeloid cells towards matrixdegrading effectors to restructure fibrotic ecm these biomimetics will be examined in advanced 3d in vitro and in vivo pancreatic tumor models the combined effects of biomimetics on the matrisome matrix architecture and singlecell transcriptomics will be integrated using machine learning to identify ecm fingerprints openmatrix will 1 deliver mechanistic insights into endogenous fibrosis drivers and antagonists 2 engage these cellintrinsic mechanisms to revert fibrosis and thereby 3 reactivate immune effector function and advance immunotherapy