Dragon09/odtu_chatbot huggingface dataset:
genomic applications for laboratory diagnostics supported by artificial intelligence

gendai will leverage metagenomic potential to deliver powerful diagnostic results facilitating the development of personalized medicine addressing assay research and development as well as productive clinical diagnostics in a comprehensive way by creating a highly innovative medical diagnostics platform that supports microbiome profiling with novel biomarkers using artificial intelligence ai this innovative platform will allow clinicians to assess and monitor patients while complying with strict regulatory requirements of laboratory diagnostics ultimately gendai will contribute to accelerate conversion of innovative ideas and technology solutions into breakthroughs in medical analyses services delivery of gendai tangible outputs will be driven by the following research and innovation objectives acreate new metagenomic datasets containing microbiome samples from stool of patients under informed consent suffering from inflammatory bowel disease ibd b develop and integrate the gendai diagnostics workflow focusing on implementing a fully automated data processing pipeline cprovide a robust cloudbased foundation for the development of the platform that integrates advanced data management and knowledge infrastructure focusing on security reproducibility and longterm archiving gendai safe d develop and improve ai methods to identify relevant biomarkers and classify corresponding metagenomic sequences in order to characterise microbiome profiles to provide a personalised diagnostic result of patients state of health gendai discovery edeliver innovative visual user interfaces and interactive clinical reporting gendai interactive reporting and f deliver the marketable regulatory compliant gendai technology and tool suite
house of light home and piety in the gülen movement

my research project will investigate the effects of certain forms of interpreting and experiencing islam on the production of moral subjects and the shaping of individual trajectories and social practices by focusing on women participamy research project will investigate how muslim spaces are created in diasporic muslim contexts from an anthropological perspective it will analyse the role that religious practices and discourses play in homemaking processes and in the production of different levels of belonging among religiously committed muslim women through the analysis of the complex ways in which the shaping of an ideal muslim self intermingles with actualizations of home outside homeland i will untangle the mechanisms through which space is made home in diverse diasporic contexts and further anthropological understandings of how religiously framed practices can shape subjects capable of living throughout the globalized world i will particularly consider the ways in which women negotiate and respond to moral constraints in the different arenas that constitute their everyday practices both inside and outside their community and how and to which extent those moral constraints affect their individual autonomy in order to do that i will conduct ethnographic fieldwork through participant observation with women members of the gülen movement in belgium whose participants are turkish followers of the charismatic religious leader fethullah gülen the proposed project builds upon expands and further develops my doctoral research on the construction of moral subjects among women of the gülen movement in brazil which demonstrates that the performance of islamic practices as they are understood by gülens followers produces a conditioned agency among women the research project will broaden my ethnographic universe and allow me to take a comparative approach to better understand the gülen movement as a whole and the specificities to its localized communities
hippocampus unites memory systems by preserving sequential order

it is generally assumed that there are two distinct memory systems in the human brain declarative memory supports memories for facts and events while the procedural memory supports motor skills however recent evidence suggests that these multiple memory systems are less independent than originally thought and that the hippocampus historically associated with declarative memory is also involved in procedural motor memory accordingly the project memunited hippocampus unites memory systems by preserving sequential order proposes and tests an integrative framework that specifies the shared neural processes that support learning and memory across multiple memory systems specifically given that declarative episodic and procedural motor memories consist of temporally organized sequences of events eg order in which guests arrived at your dinner party and movements eg playing the piano and the hippocampus is critical to preserve sequential order of experiences i will investigate whether the neural mechanisms of sequential order processing supported by the hippocampus are jointly used in declarative episodic and procedural motor memory to do so i will use stateoftheart multivariate pattern analyses of functional magnetic resonance imaging data acquired during the different phases of memory formation ie encoding consolidation and retrieval findings in the proposed research will fill a gap in the field by providing a detailed characterization of the role of the hippocampus in multiple memory systems the findings will offer the opportunity to reconsider the historical models of memory classification and develop more integrative views of memory organization in general and hippocampal functioning in particular moreover it will open new avenues for the development of integrative treatment of procedural and declarative memory deficits
historicising the privatisation of healing knowledge

privhealth aims to establish the first history of the process of privatisation of healing knowledge combining methods from history of knowledge and tools from computational history privhealth demonstrates how a legal framework that guaranteed that healing knowledge could be kept as a private asset arose from colonial exploitation and knowledge circulation between 1700 and 1900 the results of privhealth will provide a nuanced historical framework that will both shape academic historical debates and inform discussions over intellectual property rights in the medical and pharmaceutical fields at a societal level
core components supporting a fair eosc

faircore4eosc focuses on the development and realisation of eosccore components supporting a fair eosc addressing gaps identified in the sria leveraging existing technologies and services the project will develop nine new eosccore components aimed to improve the discoverability and interoperability of an increased amount of research outputs faircore4eosc will also contribute to the eosc interoperability framework by establishing new guidelines on the new eosccore components the new components will be crucial to support the fair research life cycle five usercentric case studies climate change social sciences and humanities mathematics national research information systems research data management communities will drive the development and testing of the new components ensuring they are tailored to the user needs codesign all the selected case studies share similar challenges that are common to many other stakeholder groups research communities at european and national level have datasets that currently cannot be found in the eosc they use digital object identifiers dois but they are lacking pids for different levels of aggregation they use community specific services to manage metadata that make crossdiscipline reuse and interoperability complex the user stories and best practices drawn by the case studies will be used to foster uptake of the new components beyond the project partners the 22 complementary partners of the faircore4eosc consortium have longlasting experience in the provision and development of research data services persistent identifiers metadata and semantic registries services and tools to archive and reference research software the partners have also significantly contributed to the eosc sria and are active members of the eosc association task forces tfs providing the project a unique insight and capacity to boost the development of the web of fair data and related services
electrochemically driven organocatalytic transformations of alcohols thiols and disulfides

the purpose of this research set in the context of synthetic organic chemistry is to develop unprecedented methods for electrochemically driven cleavage and subsequent functionalization of co and cs bonds in alcohols thiols and disulfides using organocatalysts based on phosphorus and sulfur these radical methods will serve as keys to unlock the potential of the targeted compound classes as feedstocks for synthesis of functional organic compounds eg pharmaceuticals as well as for biomass valorization processes due to the complexity of the targeted transformations the scarcity of available methods and the novelty of the outlined approach the research will expand the synthetic toolbox enable new retrosynthetic disconnections and latestage defunctionalization of eg carbohydrates and peptides combined with the integrated mechanistic studies the research will have a significant impact from a fundamental science perspective as well as enable new synthetic applications the project is divided into two main topics each sized for one phd student and one postdoc working together on the outlined work packages the proposed research is supported by preliminary results that indicate its viability
ultrafast atomicscale imaging and control of nonequilibrium phenomena in quantum materials

quantum materials qms are of great importance for the development of future quantum nanophotonics and nanoelectronic devices to harness their full potential and design novel functionalities it is essential to understand how their macroscopic quantum states arise from the microscopic interaction between their charge lattice orbital and spin degrees of freedom and how they respond to external perturbations while ultrafast techniques offer unique insight into microscopic interactions at global macroscopic scales they fall short of capturing the local response of a manybody quantum state directly at the atomic scalein contrast scanning tunneling microscopy stm enables imaging of stationary quantum states with angstrom spatial resolution revealing atomic inhomogeneities local disorder or how quantum phases can vary over angstrom scales such irregularities are ubiquitous in real devices and can even be a key feature of technically relevant metastable phases in these cases the global understanding of the nonequilibrium response of a quantum state is not sufficient to fully capture its properties and one must also understand the localized response directly at the relevant spatial angstrom scales yet the study of atomically localized nonequilibrium dynamics in qms has so far been out of reachin this proposal i will employ ultrafast terahertzlightwavedriven stm thzstm to i explore the response of correlated electron states to global and local perturbations and as a function of their local environment and ii induce new quantum properties by periodic driving with light to create floquet topological states and study their topological properties at the atomic scalefastomic will bridge the gap between atomic realspace and ultrafast realtime investigation of condensed quantum matter providing scientific insights and technological advances that go significantly beyond existing capabilities
discover molecular pathways for marine glycocarbon sequestration

the scientific frontier project cquest will study algal sugar polymers glycans in the ocean to resolve their contribution to global carbon cycling and sequestration cquest will explore the hypothesis that marine diatoms which fix similar amounts of carbon as tropical forests on a global scale secrete glycan types that are stable meaning harder to degrade for bacteria than other substrates this stability results in glycocarbon sequestration removing the greenhouse gas carbon dioxide from the atmosphere cquest will identify and quantify glycan structural types in seawater where salt low glycan concentration and their high molecular diversity challenge classic analytical techniques with two articles in pnas 2020 and nature communications 2021 implementing bioanalytical strategies to measure glycans in the ocean we broke through the glycocarbon challenge setting the stage for testing the glycocarbon sequestration hypothesis in the test tube my team will reveal marine bacterial enzymatic degradation pathways that degrade diatom glycans our characterized enzymes will become analytical tools to identify and quantify these glycans across the ocean in different oceanic regions we will quantify glycan production during algal blooms glycan export in sinking particles and glycan burial in sediments to pinpoint the types that have a high potential to sequester carbon the outcome will be knowledge of glycan contribution to carbon sequestration shedding light into what remains a black box of the global carbon cycle to this day cquest will discover enzymes new to science explore the potential of glycans for carbon sequestration and reveal molecular principles that govern carbon sequestration in and beyond the ocean
multiplexed microrna detection platform for early diagnosis and patient management

early detection of disease on a population scale screening relies on highly sensitive testing able to detect early molecular changes coupled with costeffectiveness that enables economic access to such testing at scalethe miracle project addresses these challenges by combining a breakthrough optical sensing approach for singlemolecule detection with creative biochemistry and computation the groundbreaking goal of this research proposal is to develop a robust diagnostic platform capable of detecting diseaseinduced changes in microrna expression by counting individual rna molecules directly in bodily fluids without the need for amplificationthis innovation will be realized by a novel computationally assisted singlemolecule detection scheme that unlike common singlemolecule detection methods enables detecting a full panel of biomarkers simultaneously in a single snapshot offering ultimate sensitivity at exceptionally lowcost these attributes make this technology suitable for largescale population screening and health managementpromising preliminary results show that miracle can detect and count individual rna targets in mixtures of synthetic mirs in physiological subfemtomolar concentrations these preliminary results highlight the potential of this approach for ultrasensitive early detection of disease and a provisional patent has been submittedwithin the proposed project a proof of principle will be performed on a cohort of lymphoma patients and healthy controls that will be classified by the miracle approach the technology will be benchmarked against existing stateoftheart methods such as rna sequencing and quantitative pcr
mechanisms of dormancy activation and sexual conversion in preerythrocytic malaria parasites

malaria remains a devastating public health burden the estimated death toll in 2020 was over 600000 its eradication is a desirable goal however the development of novel intervention strategies is hampered by limited current understanding of the biology of plasmodium the causative agent of malaria and of its complex interactions with mammalian and mosquito hosts in the liver inside hepatocytes plasmodium parasites can either 1 replicate forming new parasites that will infect erythrocytes and cause disease or 2 remain dormant which can lead to chronic relapsing disease weeks to years after the original infection i recently discovered new hepatic outcomes using a novel pipeline for singlecell hepatocytepathogen sequencing i have identified subpopulations of sexually committed parasite forms previously thought to appear only during erythrocytic infection this groundbreaking insight into the plasmodium life cycle can change our understanding of malaria transmission yet it remains unknown how malaria parasites commit to these different developmental outcomes in hepatocytesdexes will test the hypothesis that plasmodium liver infection outcomes depend upon the metabolic state of the host hepatocyte using engineered human microlivers new humanized mouse models transspecies studies and singlecell technologies i will 1 identify parasiteencoded molecular mechanisms implicated in the induction and maintenance of dormancy activation and sexual conversion in the liver and 2 establish the bidirectional relationships between host metabolism and distinct parasite cell fates and their impact on treatment outcomes this project will uncover the molecular mechanisms underpinning dormancy relapsing and transmission of malaria parasites and lay the groundwork for the future development of new therapies targeting the liver infection reservoirs
electrochemical interfacial engineering of metal organic frame work towards aluminium solid state batteries

aluminium solidstate rechargeable batteries are promising candidate for postlithium ion batteries the electrolyte system of rechargeable aluminium batteries is an urgent research problem that is preventing its widespread implementation the prime aim of the research proposal is electrochemical interfacial engineering of metal organic frame work mofs based electrolyte towards aluminium solidstate battery applications study of mofs are key topic in materials science sector over the past decade for facilitating next generation nanoelectronic devices tuning the porosity of mof can provide controllable functionality an ideal platform for investigating the underlying mechanism of solidstate electrolytes sses and their ion conduction and the structure property relationships this research proposal will address the challenges in the conventional liquid electrolytes and existing sses the potential impact of the project proposal are traditional liquid electrolytes and conventional inorganic sses can be replaced by flexible costeffective and high porous mof based sses for high performance and environment friendly aluminium batteries the specific research objective of the project are o1 facile synthesis of costeffective and highperformance nanostructured mofso2 encapsulating an infinitesimal ionic liquid il into mofs to construct an ilmof solid electrolyteo3 understanding the inherent electrochemical interface and studying the underlying structureproperty relationship of ilmof based sseso4 demonstrating a cost effective and environment friendly aluminium solid state battery with high specific power density using synthesized solid electrolyteresearch results will be published in reputed high impact open access international journals and conferences this project is in line with the eu strategy for the energy storage devices for the transition to a low carbon economy based on renewable energy source
invisibility of multilingualism in amdo tibet

this project will study how multilingualism and linguistic diversity are materialised in the linguistic landscape of amdo tibet this region is situated in the northeast part of the tibetan plateau and encompasses the presentday chinese provinces of qinghai and gansu the area is known for its ethnolinguistic diversity amdo tibet is inhabited by several groups such as han chinese the major ethnic group in china tibetans chinese hui chinesespeaking muslims the muslim turkicspeaking salar and mongolicspeaking buddhist populations language policies intense urbanisation migration and socioeconomic opportunities and imperatives have an impact on language practices and language use among ethnic groups this project looks at these changes from the angle of language use in the linguistic landscape this research studies ethnolinguistic diversity in space focusing on public signsthe object of this study is the town of rongwo the county seat of the rebgong chinese tongren tibetan autonomous county in qinghai province peoples republic of china where tibetan and chinese are coofficial languages the town constitutes the main administrative and commercial centre of the area and features schools administrative offices hospitals and different kinds of businesses such as restaurants and clothing shopsthis project draws on linguistic and visual data available in public signs ethnographicallyinformed data and data on regulations of languages in space the analysis will be based on a holistic approach that considers the informative and symbolic role of the languages involved the language policies and ideologies at play and language norms and language contactthe broader goal of this project is to understand the creation and management of ethnolinguistic diversity and linguistic hierarchies in urban space through languages scripts and other visual and semiotic means
neural circuits enabling navigational simulations

one of the most notable features of the brain is the ability to simulate possible consequences of a behavioural choice that has not even been experienced in the real world while this ability is likely fundamental for our intelligence and creativity its neural circuit basis is largely unclear to tackle this problem we will focus on the rats ability of spatial navigation finding an optimal path to a remote destination that is located outside the range of sensory perception this ability is thought to be supported by the brains internal map that allows an animal to estimate its future position followed by planned movements while the hippocampal formation has been the primary focus of research on the brains spatial map it mainly tracks an animals position and its nearby trajectories by contrast the brain has another internal map in the orbitofrontal cortex ofc that points to an animals goal destination throughout navigation because this goal coding emerges autonomously in the network without relying on explicit external cues it can be considered part of the brains inner reasoning process for future behaviours here we will explore how this internallyset goal can emerge in the ofc network through interactions with its associated regions thalamus and neuromodulatory systems we will then explore how this goal coding can be used to plan an optimal goaldirected path by avoiding known obstacles in the environment since this process likely requires the cooperation of two internal maps in ofc and the hippocampus we will elucidate the underlying circuit mechanism that employs multiple map systems in parallel we will take advantage of stateoftheart experimental and analysis techniques to decipher neural codes for navigational simulations the ofc and the hippocampus are the regions often affected by psychiatric disorders and their role in inner reasoning may provide new insights into their pathophysiology