Dragon09/odtu_chatbot huggingface dataset:
the design creation and survival of democratic laws

democracies are constantly confronted with the challenging task of merging widely diverging worldviews interests and values into coherent legislation given the increasingly hostile political climate around the world solving this task has never been more difficult and more important than today yet despite the crucial relevance of laws for our daily lives and the legitimacy and effectiveness of democratic government our understanding of how the design creation and longterm survival of legislation are related is still very limitedthe demolaw project analyses legislative texts in three different political systems us uk eu with cuttingedge computational methods to answer three major research questions 1 which conceptual dimensions capture the design of a law and how can we exploit textual properties of law texts to measure these dimensions empirically 2 why does the design of democratic legislation vary across laws policy domains and political systems 3 how can we explain why some laws are entirely stable over time while others are constantly adjusted and sometimes transformed fundamentallythe project makes three major contributions first it provides an entirely novel conceptual perspective on the design of democratic laws by focusing on two analytical dimensions that are central to any piece of legislation versatility and precision this innovative approach allows us for the first time to measure and compare the substance of legislative output across and within policy domains political systems and over time second the project will develop and test an integrated theoretical framework on both the creation and the survival of democratic legislation and thereby advance the theoretical stateoftheart in comparative public policy finally the projects groundbreaking methodological approach will pave the way for a computational analysis of legislative content and will thereby push the boundaries of how we study democratic decisionmak
photonic vector network analyzers

the deployment of 5g networks and the upcoming deployment of 6g in the next decade is essential to advance wireless communication for keeping pace with modern data hunger 6g will incorporate first channels in the terahertz domain 100 ghz 10 thz however terahertz technology in communication applications has a main bottle neck the lack of powerful sources and versatile components in order to engineer these towards maturity sophisticated characterization tools are required to identify design flaws the most prominent of these are vector network analyzers vnas a class of systems currently dominated by electronics meanwhile photonic technologies start to become competitive with established electronic technologies in the lower thz band and already excel beyond 1 thz in terms of dynamic range optical comb technologies enable frequency accuracy and stability beyond that of electronic systems potentially at a fraction of the cost this project aims for the development of two photonic prototype systems i a photonic frequency extender for the wr10 band compatible with electronic base band vnas and ii a completely photonic vna based on a frequency comb with a bandwidth of several thz spectral purity better than that of electronic vnas and seamless tunability over the whole range the technology to be developed in this project will simplify characterizing devices over a larger frequency range at much lower cost enabling large scale deployment of vna systems this will in turn foster development of terahertz systems for further key applications besides communication eg in spectroscopy including medical applications industrialscale nondestructive testing and quality control as well as security
kedge imaging for color spectral photoncounting computed tomography in lung diseases imaging

computed tomography ct is the mainstay of lung imaging because of its higher spatial resolution convenience availability and faster time of acquisition in comparison with other imaging methods such as magnetic resonance imaging mri and nuclear imaging however cts lack of specificity and absolute quantitative capabilities limits the comprehensive guidance of therapeutic strategies based on imaging assessment of oncologic inflammatory and fibrotic pathophysiology processes spectral photoncounting ct is an emerging ct technology that not only capitalises on all cts advantages but also offers a cuttingedge method of imaging called color kedge imaging this method allows the specific and quantitative identification of one or multiple atoms concomitantly within a tissue enabling the simultaneous imaging of independent or interacting pathways however kedge imaging is still limited by its low sensitivity and the scarce availability of contrast agents for potential human translation and therefore has not been translated yet to practice addressing these issues would be extremely beneficial to the diagnostic and theragnostic evaluation of lung diseases in general and more specifically lung fibrosis and cancer therefore the goal of this proposal is to develop a framework of spcct color kedge imaging to provide highresolution specific and quantitative imaging for nontargeting and targeting agents candidates mainly from the nanobiotechnology field we will carry out preclinical studies to evaluate the contribution in combination with the contrast agents using different routes of injection either by intravenous injection or inhalation on key lung applications cancer and fibrosis this will open to the concomitant imaging of lung ventilation and perfusion for monitoring the inflammation and pulmonary agent delivery in animal models
natural scavenger repellents from xenorhabdus and photorhabdus

the ecology of xenorhabdus and photorhabdus xp bacteria requires the production of bioactive natural products against invertebrates vertebrates bacteria and fungi xpdeter will especially selected metabolites for their application in agriculture xpdeter aims to i validate promising compound classes in the lab and in the field in different bioassays ii create and test a library of synthetically and more accessible derivatives and iii produce the optimized metabolites biotechnologically in xp chassis strains ultimately the production iv of these metabolites will be introduced in xenorhabdus and photorhabdus bacteria that already produce potent bioactive natural products in order to achieve extracts showing a combination of different bioactivities the currently most promising metabolite class its chemical synthesis and biotechnological production were all developed as part of the erc adg synpep 835108 within xpdeter we will apply this knowledge to develop a natural productbased environmentally friendly and economically feasible product that can be combined with or can even replace currently used synthetic and often harmful chemicals in agriculture
next generation laconic cryptography

communication efficiency is one of the central challenges for cryptography modern distributed computing techniques work on large quantities of data and critically depend on keeping the amount of information exchanged between parties as low as possible however classical cryptographic protocols for secure distributed computation cause a prohibitive blowup of communication in this settinglaconic cryptography is an emerging paradigm in cryptography aiming to realize protocols for complex tasks with a minimal amount of interaction and a sublinear overall communication complexity if we manage to construct truly efficient laconic protocols we could add a cryptographic layer of protection to modern datadriven techniques in computing my initial results in laconic cryptography did not just demonstrate the potential of this paradigm but proved to be a gamechanger in solving several long standing open problems in cryptography eg enabling me to construct identitybased encryption from weak assumptionshowever the field faces two major challenges a current constructions employ techniques that are inherently inefficient b the most advanced notions in laconic cryptography are only known from very specific combinations of assumptions and are therefore just one cryptanalytic breakthrough away from becoming voidthis project will make a leap forward in both challenges i will systematically address these challenges in a work program which pursues the following objectives i develop new tools and mechanisms to realize crucial cryptographic primitives in a compact way ii design efficient protocols for advanced laconic functionalities which sidestep the need for inherently inefficient lowlevel techniques and widen the foundation of underlying assumptions iii strengthen the conceptual bridge between laconic cryptography and cryptographically secure obfuscation transferring new techniques and ideas between these domains
pandemic information to support rapid response

it is clear that critical pandemic decisions need to link rapid reliable testing with comprehensive modelling of potential impacts currently europe lacks a comprehensive one 1 a diagnostic point of care instrument panpoc for rapid detection of respiratory rna viruses with pandemic potential influenza a human avian and swine influenza b and betacov sarscov2 variants and emerging betacoronaviruses the target viruses panpoc will be validated by testing animal environmental and clinical samples one health approach 2 a prognostic aibased platform panrisk to predict the spread of the target viruses and contribute to public health by giving an alarm once an outbreak exceeds a given threshold the platform is based on a pathogen genomic drifting model to predict the risk of animal pathogens drifting to become human pathogens and an epidemiological model to predict geographical and temporal outbreaks of zoonosesthe portable panpoc equipment will be validated and demonstrated at endusers hospitals general practitioners competent veterinary authorities health authorities border controls airports refugee camps etc the aim of panrisk is a syndromic surveillance framework for diseases for targeting directed surveillance in concentrated periods of time and areas the advantage of the panrisk model is targeted towards zoonotic diseases with high precision data that allows high precision in the surveillance for trends the contribution of social sciences and humanities ssh is integral to the project an ssh partner will focus on social and health inequities in the pandemic preparedness and aims to provide indications for the implementation of the ppp to support the involvement of stakeholders as well as public trusta policy development partner will align the projects output to the key policy development and implementation processes within the eu a dissemination and communication partner will ensure efficient communication dissemination and engagement of the stakeholders
everyday aesthetic value

understanding the nature of aesthetic value is important because it forms a big part of what makes our lives worth living in the last 1015 years there has been an upsurge of interest in theories of aesthetic value however most of this work has focussed on understanding the value of artworks and artefacts and this has created a blind spot in understanding the nature of aesthetic value the realm of everyday aesthetic phenomena everyaesthetic addresses this lacuna by developing an innovative approach to aesthetic value that takes seriously the extent of its diversity and fullness in our lives it has two research and innovation objectives first it aims to identify and elucidate the challenges that everyday aesthetic phenomena pose to prominent existing theories of aesthetic value second it aims to develop answers to two key questions regarding the nature of everyday aesthetic phenomena namely how to demarcate these phenomena as aesthetic and how to explain what makes them valuable everyaesthetic makes a timely critical intervention in current debates about aesthetic value and it offers a foundational contribution to literature on everyday aesthetics bridging the gap between these two fields of research the supervisor prof elisabeth schellekens is a worldrenowned philosopher who specialises in questions concerning aesthetic value the host institution the department of philosophy at uppsala university uu has an exceptionally strong research record in aesthetics both are ideally placed in europe to facilitate everyaesthetic by supporting me to gain the expertise i need to pursue its objectives and enhance my employability meanwhile i will transfer knowledge i have spanning the disciplines of philosophy and art history to the department at uu by undertaking a variety of knowledgetransfer and dissemination activities including delivering a postgraduate course delivering guest lectures and participating in its programme of research events
widen performance in research and innovation capacity and competence across eu

our consortium consisting of partner institutions from czechia north macedonia ukraine finland and sweden have diverse experience with participation in horizon europe he synergic eu ri funding smart specialisation clusters and other international ri funding schemes consider this call as the opportunity to strengthen institutions from widening countries and upscale them on higher level through capacity skills and competence building and networking actionsthe key objective of the project wide acrosseu is to move us participants from widening countries the core group 3 higher education institutions from the czech republic north macedonia and ukraine who are formerly a current single beneficiaries of regional funding programmes erdf ipa interreg and similar investments for ri infrastructure to higher level and prepare us for wider and more successful participation in direct eu funding programmesthe specific objectives which are1 to map the needs and requirements of target groups in widening partners state of play2 to strengthen competitiveness of target groups in widening countries by acquiring new transferable skills for ri staff3 access to networks and partnerships to secure more successful proposal and create a base for lead partner roles for widening partners4 to better use ri infrastructure funded under erdf or similar investments5 to create strategies for ri and human resources6 to improve access to excellent european ri networks and communitieswill be achieved through following work packageswp1 need of analysis for capacity and competence buildingwp2 acquisition of new transferable skillswp3 exploitation of ri funding opportunities networkswp4 ri valorisation policy support and synergieswp5 dissemination communication and exploitationwp6 management and coordinationthe project will last 40 months
isolation and analysis of extracellular vesicles using optofluidics for the evaluation of microsatellite instability in endometrial cancer

endometrial cancer ec is the most common gynaecological cancer and has an estimated incidence rise of more than 50 worldwide by 2040 mainly associated with increasing obesity prevalence in 2018 alone there were approximately 380000 new cases and close to 90000 deaths attributed to ec worldwide thus there is a growing need for the development of better platforms for inexpensive early stage ec diagnosis and treatments immunotherapy has shown a sharp increase in survival rate in various cancers but only in a small percentage of treated patients the lack of reliable biomarkers for the selection of this subgroup of patients is a great hindrance to its broader application in the clinical setting however microsatellite instability msi has been shown to be a good candidate for immunotherapy selection msi evaluation requires genetic material from tumors which can be found in extracellular vesicles released by ec cells to the bloodstream isolation and analysis of extracellular vesicles using optofluidics for the evaluation of microsatellite instability in endometrial cancer evolve is thus a project focused on the development of an integrated solution for the enrichment and analysis of extracellular vesicles from body fluids of endometrial cancer patients to assess microsatellite instability using labonchip microfluidics methods in conjunction with dna biomarkers and surfaceenhanced raman scattering technology
mathematics of scattering amplitudes

mascamp proposes a new paradigm for fundamental interactions in physics in the form of a unified mathematical approach to scattering amplitudes the project brings together a multidisciplinary team with expertise in pure mathematics and theoretical physics who will develop a set of novel and efficient algorithmic methods with applications in mathematics particle physics and gravitydiscoveries in many areas of fundamental physics depend upon a detailed understanding of the scattering of particles modern experiments such as particle colliders and gravitationalwave detectors demand highprecision theoretical computations to make new discoveries these are deduced from physical models by a highly labourintensive process relying on the calculation of scattering amplitudes which assign probabilities to particle interactions despite a tremendous worldwide effort over many decades the methods used to compute increasingly complex scattering amplitudes remain disparate and fragmented the work of the pis in distinct domains suggests unexpected symmetries and universal rules obeyed by scattering amplitudes in differentlooking areas of physics this calls for a radically new way of studying scattering amplitudesmascamp will create a unified framework for the calculation of general scattering amplitudes by building upon the latest research in mathematics notably in algebraic geometry and number theory as a result mascamp will overcome longstanding computational bottlenecks push the boundaries of numerous areas of theoretical physics such as quantum field theory gravity and string theory and inspire new mathematical research a widely applicable computer software implementation will enable physicists to make previously inaccessible predictions for present and future experiments a project of mascamps scope and ambition is only achievable by combining the unique expertise of the pis in complementary areas of mathematics and physics
development of rationally designed enzyme kits

enzymes exhibit high efficiency specificity selectivity biodegradability nontoxicity and the ability to function effectively under gentle biological conditions these qualities render enzymes a sustainable and ecofriendly substitute for traditional catalysts within industrial settings however harnessing enzymes for industrial applications often necessitates extensive and costly experimental engineering efforts computational methods hold promise as potential solutions but these have not yet demonstrated the ability to rapidly design highly efficient enzymes that mimic those found in nature as opposed to other methods our computational approach developed in the previous ercstg can introduce active site and distal mutations that modulate the enzyme conformational dynamics achieving increases in catalytic efficiency of up to 1000fold this project aims to exploit the proprietary technology developed in ercstg and ercpoc for generating a set of patentable rationally designed enzyme kits focused on stereoselective carboncarbon bond formation kitzyme aims to create a spinoff for the exploitation of the new set of rationally designed enzyme kits as well as the proprietary technology developed for enzyme optimization both the enzyme kits and our technology are the cornerstone of the project and will provide industries with a costeffective scalable and environmentally sustainable solution
towards a digital twin for forecasting of power production to wind energy demand

the expected growth of both on and offshore wind energy is enormous and many new wind parks are planned for the coming years experience from the existing wind farms shows the importance of a proper micrositing of the wind turbines as well their efficient interconnection within the farm in addition bringing wind farms together into clusters toward a wind power plant concept might induce long distance negative interaction between the farms reducing their expected efficiency this might happen both on and offshore the high amount of connected wind power and the expected increase during the coming years requires that this technology has to be prepared to take a more important role as of its contribution to the reliability and security of the electricity system the present proposal windtwin targets to develop and validate an offshore wind farm digital twin dt for highly accurate prediction of power production and energy demand of the end user the dt will give users tailored access to highquality information services models scenarios forecasts and visualisations as a central hub for offshore wind decisionmakers and will also serve as platform offering users access to a comprehensive array of highquality resources services models scenarios forecasts and visualisations windtwin seeks to revolutionise the way industry professionals make informed choices to reach windtwin expected impact the ambitious innovationled research proposed necessitates bringing together a range of skills and expertise which cannot be found within a single member country or institution we have put together a unique team that has a broad range of expertise through the whole wind energy development process ranging from the management of wind energy production and development of industrial codes numerical methods algorithms ensuring the uptake of improved methodologies the windtwin consortium consists of 13 organizations from 7 different member states
electrochemical stereoselective radical cascades for accessing naturallike compounds

identifying successful lead drug candidates is a significant and current challenge to society the electroasymmetric project seeks to provide some solutions through assisting the development of more effective drug discovery technologies specifically we aim to use electricitydriven organocatalytic cascade processes for the stereocontrolled synthesis of chiral lactones and polyfunctionalized heterocycles which are common motifs in biologically active molecules asymmetric organocatalysis and electrochemistry two powerful strategies of modern chemical research have extraordinary potential for sustainably preparing the novel organic molecules required for driving innovation in the pharmaceutical industries however the control of enantioselectivity in electrochemical radical processes poses a fundamental scientific challenge electroasymmetric asks whether asymmetric organocatalytic electrochemical cascades could be an effective tool for rapidly synthesising novel chiral natureinspired building blocks with high stereocontrol the chiral molecules prepared in this project will be screened for biological activity in a multidisciplinary collaboration with janssen increasing the probability of success in identifying successful drug candidates this fellowship brings a new industrial collaboration to the host institution and transfers expertise of advanced techniques in asymmetric catalysis to the candidate and knowledge of electrochemistry to the host group the projects multidisciplinarity and intersectoral nature will broaden the fellows competencies and will place him in a competitive position for his next career move