Dragon09/odtu_chatbot huggingface dataset:
hybrid electrochemicallypaired light irradiated organic synthesis

the synergy of visible light and electrical energy has been employed for decades in water splitting to hydrogen but only recently was used to power the synthesis of higher value complex organic molecules natural products pharmaceuticals synthetic photoelectrochemistry pec is receiving notable attention due to its enhanced scope of redox transformations sustainability and selectivity compared to photo or electrochemistry alone synthetic electrochemistry ec is a useful synthetic tool that replaces atomuneconomical chemical redox agents with simple electrons and protons however in most ec reactions and in all pec reactions only one halfreaction of the cell is optimized to generate value the other halfreaction sacrifices its own electrode or redox additives paired electrolysis where both halfreactions afford useful species is key to sustainability and efficiencyhelios will discover develop and disseminate paired synthetic pec reactions intermediates generated by both halfreactions are converged in novel creative chemical transformations includingi marriage of radicals or ions generated by each halfreaction to furnish phenethylamines and azetidines valued pharmaceuticalsii ringfusing reactions that furnish bicyclic scaffolds toward molecules with high 3d character urgently required in drug discoveryiii alcohol inversion reactions that are catalytic environmentallyfriendly and use mild conditionsmultifunctional catalysts will be used that can be electroactivated in both cathodic and anodic halfcells to photochemically generate and stabilize reactive intermediateshelios i harnesses electrical and light energy to rapidly convert cheap abundant chemical feedstocks to valueadded complex molecules and ii improves the sustainability and selectivity of synthetic pec and ec processes helios opens an entirely new dimension of chemical reactivity that will revolutionize the way chemists use redox to synthesize molecules
computational design of industrial enzymes for green chemistry

catalysts are able to reduce activation barriers of reactions making them possible at lower pressure an temperatures enzymes are the most efficient specific and selective catalysts known green chemistry has emerged as a new area focusing on use of environmentally friendly nonhazardous and efficient solvents and catalysts in the synthesis of new products enzymes are nontoxic and capable of operating under mild biological conditions which makes them green catalysts offering an attractive alternative to traditional catalysis however their application in industry is rather limited as most industrial processes lack a natural enzyme the solution is the routine design of enzymes but this task has not yet been achieved due to several limitations such as the high complexity of enzyme catalysis the lack of accurate computational approaches for designing and estimating the catalytic potential of the new variants and the inability to identify potential mutation sites far away from the active site of the enzyme greenzyme provides a new protocol able to capture this high complexity and design new enzymes capable of predicting active site and distal mutations thus achieving high levels of activity as it would occur in nature this is achieved by integrating current shortest path mapancestral sequence reconstruction spmasrbased computational protocol developed in previous projects such as the ercstg netmodezyme with deep learning techniques thanks to a wellthoughtout exploitation and communication strategy will make possible the premise of routine enzyme design this will have a largescale socioeconomic impact as it will reduce the production costs of many drugs and will allow industries to use environmentally friendly alternatives in line with new european policies
lifelong health monitoring and assessment for lifetime maximization of liion batteries

lithiumion liion batteries have an integrated battery management system bms whose performance is critical in maximizing the available life of the batteries and increasing their sustainability the bms monitors state parameters such as stateofcharge soc and stateofhealth soh for safety and performance optimization purposes the accuracy of these parameters plays a critical role in maximizing the available battery lifetime this msca fellowship project aims to maximize the available lifetime of liion batteries and subsequently the lifetime of their applications by making the battery impedance accessible in realtime for the bms state estimation algorithms by using a novel ternarysequence impedance measurement method that is integrated onboard the battery pack the impedancebased soc and soh estimation algorithms will offer higher accuracy compared to the available traditional algorithms thus the bms will be able to optimize the batterys use and consequently maximize its life in its primary application ie firstlife application such as in electric vehicles despite lacking the performance for the primary application the battery is still likely to be used in a less demanding application ie stationary energy storage with adequate health information available using the novel impedancebased algorithms at the end of its firstlife the battery will become an attractive candidate for secondlife application as reliable predictions can be made about its remaining lifetime safety and economic value with firstlife maximized and second life provided for the battery pack the lifetime of the battery is significantly prolonged before the eventual recycling increasing liion batteries sustainabilitythis highly innovative project has a high scientific economic and societal impact furthermore the project will allow the applicant to enrich his technical and managerial skills thus boosting his career prospects and enlarging his horizon
coherent control of spin chains in graphene nanostructures

elementary nuclear and electronic spins are called to be key components in the second quantum revolution their atomicscale integration into scalable platforms with tunable interactions is a demand that i will address in conspira by synthetizing graphene architectures with interacting spin chains using customized onsurface reactions of organic precursors and by controlling their quantum state through microwave spectroscopies i envision the formation of collective magnetic states through the assembly of interacting electronic and nuclear spins in periodic arrays with atomically precise spacings through rational design and synthesis strategies we will tune spin interactions via the graphene host and hyperfine coupling with the goal of bringing the quantum state of the arrays into different regimes of energy coherence and topology to access the broad energy range of such multiscale interacting system and to probe its quantum dynamics we will combine two antagonist experimental techniques like scanning tunnelling microscopy stm and cavity quantum electrodynamics qed this will be realized by incorporating superconducting coplanar waveguide resonators cwrs as substrate of a low temperature stm we will use qed techniques to couple the resonant states of spin chains with microwave photons of the resonator while the stm tip acts as a local gate the mhz and picometer resolution of this new type of spectrometer will enable us to study the quantum coherence of the spin arrays and undertake the coherent control of distant nuclear states entangled through the electronic spin system a potential system for qedbased quantum computation conspira will provide a new platform for quantum spins and methods to address and manipulate their coherent state the combination of qed and stm represents a groundbreaking experimental development which is called to boost studies of general correlated phenomena in condensed matter physics
growing up among bright books and generous genes the intergenerational cycle of educational achievement

poor educational achievement in childhood is a major risk factor for poor health and low income in adulthood poor educational outcomes tend to run in families generating a cycle of inequality children whose parents talk and read less to them tend to struggle in school this parentchild association has been interpreted as a causal effect of parenting but parents provide their children not only with a rearing environment but also genes we can only discover causal effects of the home learning environment eg parentchild interactions reading storybooks if we control for genetics or run an rct my overarching aim is to discover which aspects of the home learning environment causally impact childrens language reading and math development intergen will use a variety of innovative observational and experimental designs we will employ existing rich datasets and collect novel data to triangulate four intergenerational ie parentchild designs using an onlinelearning platform we will assess parent and child literacy and numeracy in 3000 twin families in an rct 2000 of these families will get access to the onlinelearning platform to boost the home learning environment intergen will 1include geneenvironment interplay in studying childrens motivation literacy and numeracy development2discover which features of the home learning environment have a causal impact on learning 3test the effectiveness of offering families an onlinelearning platform to practice literacy and numeracymy training and established network in both education and genetics combined with recent breakthroughs in statistical modelling genefinding work and educational technology make me uniquely suited to lead this timely project intergen has the groundbreaking opportunity to unravel the mechanisms underlying familial educational disadvantage this will inform policy on how to target malleable causal mechanisms to ensure that all children can learn and thrive
tellchloroplasts trafficking of news on extracellular latest likely danger to chloroplasts

plants have evolved a sophisticated system to perceive and transmit external stimuli to the cell interior and inform growth and defense the host lab discovered a new pathway linking the pm to chloroplasts and regulating defence based on inducible protein relocalization coopted by pathogens during evolution both the plant protein calcium dependent protein kinase 16 cpk16 and the viral protein c4 from tomato yellow leaf curl virus relocalize from the pm to chloroplasts upon activation of pathogen associated molecular pattern pamptriggered immunity pti from the organelle cpk16 acts as a positive regulator of downstream defence responses while c4 acts as a suppressor however the molecular and cellular events enabling and regulating protein trafficking from pm to chloroplasts remain elusive preliminary data in the host lab found the colocalization of c4 with syp61 and ara7positive compartments upon flg22 treatment among them c4 colocalizes with ara7 at the periphery of chloroplasts upon flg22 treatment cpk16 was also able to form mobile dots in the cytoplasm these results suggest that endocytosis is likely to be involved in c4cpk16 trafficking from the pm to chloroplasts in addition phosphorylation regulation and nterminal cleavage could also regulate the pmtochloroplast protein trafficking as evidenced by mass spectrometry analyses in this project i will utilize both cpk16 and c4 to investigate the molecular determinants underlying the protein trafficking from the cell surface to chloroplasts including how proteins are transported from the pm to chloroplasts objective 1 and how nmyristoylated c4 and cpk16 are released from membrane compartments prior to chloroplast import objectives 2 by using cell biology protein biochemistry molecular biology and plant genetic methods this project will expand our understanding of the pmtochloroplast protein trafficking and serve as stepping stone for the engineering of immune responses
the fragments of aristotle a reconstruction of his lost works

one of the greatest minds of antiquity was no doubt aristotle he left a lasting impression on western civilization influencing among others the founding fathers in designing the us constitution but what many do not know is that only a fraction of his works survive those preserved through medieval transmission his socalled esoteric works go back to college lectures and were intended to be used by his small circle of students but aristotle also wrote many works for a wider audience which survive only in fragments ie citations in later authors and a number of epitomes in fact what is preserved today is not what aristotle was famous for throughout most of antiquity or even what he intended to be known for yet modern research focuses almost exclusively on the esoteric works the result is that the aristotle one meets in contemporary scholarship is really only the aristotle of the preserved school writings in order to truly understand his views on politics ethics poetry rhetoric logic and the soul or his approach as a scientist and historian we must also study the lost works the fragments are essential to understand his philosophy and assess his impact on western thought fragarist aims to shift the attention back to what were initially his most important works and establish a new understanding of aristotle by reconstructing and interpreting his lost works we will combine methods taken from philology papyrology philosophy ancient history and digital humanities and apply pioneering editing techniques and the latest cuttingedge imaging techniques for the first time we will also incorporate the fragments found in syriac and arabic sources we will create a radically new perspective on aristotles personality and elucidate his influence on later authors including the alexandrian grammarians roman philosophers neoplatonic philosophers and christian authors this will also revolutionize our knowledge of the history of literature and science
propelling the shift toward the future of circular safe and sustainable packaging and single use device ecodesigned solutions through healthcare environments

the healthcare sector is hindered by several barriers that hamper the application of circular economy principles eg the safety restrictions of the domain limit the use of recycled materials due to the need of materials biocompatibility and safety in products to be used in the human body led by a multidisciplinary consortium of 39 partners plus 13 industry affiliates from 15 eu countries plus uk and usa enkore aim to tackle challenges and develop an ecodesign framework that supports the development of safe and environmental compliant devices ecoresponsible packaging which minimize the environmental impact reduce the carbon footprint and maximize the use and preservation of resources the main goal is to connect the design of the medical devices packages with the endoflife stage thus the technologies that support circularity are taken into account at the medical device conception stage enkore framework will be validated in 5 reference use cases rucs led by 5 different health regions that bring hpcs and policy maker 3 large eu hospitals and the reference network for european regional and local health authorities euregha the project developments and rucs are supported by several associations and ngos a packaging manufacturer and a group of smes and researchers specialists in circularity lca social sciences environment circularity and materials the validation of the framework shall provide evidence to work with policymakers creating new or revised standards and create tangiblequantitative evidence policy making and regulatory engagement will be strongly performed the methods and tools comprise environmental and social life cycle assessment elcaslca circularity calculator cc and digital product passport dpp approaches which could be adapted during the second stage of the proposal
handshake complexes of chiral nanoparticles and proteins

chirality or the absence of mirror symmetry is omnipresent in both biological and abiological forms of matter rapid progress has recently been achieved in the synthesis of chiral inorganic nanoparticles nps of great interest because of the giant optical activity observed in individual nps and their assemblies such nanostructures yield chiral features at multiple length scales resulting in a huge diversity of chiral morphologies the field is expanding toward connecting chirality across the worlds of nano and bio linking optical and biological chiral functionalities however what is currently hampering realworld applications is the step from intuitive synthesis of chiral nanostructures to a purposeful design for specific interactions with biological components the main objective of chiralpro is to develop a widely applicable methodology to design chiral nps with exceptional optical activity for strong and predictable enantioselective interactions with nanoscale biological entities such as proteins and amyloid fibrils the fundamental understanding of the role of chirality in the recognition between inorganic and biological chiral structures will be used for the programmed assembly into optically active nanofibers and for case studies in sensing and metamaterials to reach this ambitious goal the complementary expertise of all three partners involved will be essential synthesis and assembly of chiral plasmonic nps lizmarzn threedimensional electron microscopy of nps and the visualization of their interactions with biomolecules in liquid bals and selfassembly methods and computational predictions for chiral multiscale interactions kotovin addition to groundbreaking advancements in fundamental research the high gain of this work can be found in the generation of a toolbox enabling the scientific community to shift from guessing to precise design of chiral nanostructures with predefined properties
enhanced solar pv performance through improved research infrastructure for adapted climate conditions

73 of the global co2 emissions are generated by the energy sector including transport and buildings electrification combined with power generation using low carbon renewable energy sources represent a viable path to tackle climate change in this context solar power represents today not only the cheapest energy source but also the quickest to deploy solar power installations particularly pv have been growing exponentially a trend which is expected to continue especially considering the fluctuating and volatile gas and oil markets in an energy system where solar photovoltaic power will represent the major energy source potentially up to 69 of the global energy supply by 2050 the need to understand improve and forecast the operations of pv plants becomes critical for the security and safety of the society cactus proposes to improve the research infrastructure ri and its portfolio of services for an enhanced solar pv performance particularly adapted for various climate conditions such as tropical desert temperate considering the whole lifetime of pv projects from design installation operations decommissioning and end of life this will be achieved by linking outdoor and indoor measurements with physical parameters based on material analysis improving algorithms for om developing common data treatment procedures assessing sustainability related aspects while enhancing biregional scientific cooperation eulatam in the renewable energy sector
heritage ecologies culture resilience and development in island states

this proposal investigates the role of cultural heritages in promoting local economic development and social and environmental resiliences in the context of small island states sis small island and developing states sids and sub national island jurisdictions snijs located in europe the african continent and in the indian ocean small islands are extremely vulnerable to climate change due to their small size and exposure to sea level rise affecting their social and economic development crossing anthropology heritage environment development and island studies this research aims at integrating institutional heritagization processes and indigenous knowledge systems in actions for sustainable futures this project will be hosted by the islands and small states institute issi of the university of malta one of the few european entities in island studies and insular development and supervised by dr stefano moncada specialist in development economics climate change and sustainable development and by professors lino briguglio and godfrey baldacchino world leading scholars in small states and islands studies addressing the challenges at european and global level of informing effective responses to mitigate social economic and ecological consequences of climate change this project will focus on the sis of malta the sids of comoros mauritius and seychelles and the snijs of the french island territories of reunion and mayotte through an innovative interdisciplinary methodology this research contributes with ethnography and cultural studies to sustainable development theories and brings socioeconomic resilience analyses to heritage studies this research will contribute overall to the role of malta and of sis in the un actions for sustainable development the eu development and cooperation actions and the missions of the horizon europe 20212027 framework
human pluripotent stem cell registry hpscreg

the human pluripotent stem cell registry hpscreg is providing validated information about human embryonic stem cells esc and other human pluripotent stem cells psc such as induced psc this information is linked through an unique persistent identifier and it includes data on ethical provenance and scientific quality cell line application and clinical studies performed with hpsc the open access registry acts globally to provide a transparent resource and tool for psc to maximize cell utility reproducibility and benefit and minimize research ethical and regulatory risks it validates and certifies the registered cell lines based on the provided documents data and information assuring high quality of certified lines hpscreg is involved in multiple euprojects international consortia and organizations to provide information data standards and support dissemination the main task of hpsccreg within this project proposal are to maintain and improve its function as a centralized registry of hesc and hipsc lines allowing for i transparent validation and monitoring of the ethical and scientific developments in the field ii transparent data based certification of psc to assure and maintain highest quality iii implementing fair data standards and a continuously improved data reliability in downstream stem cell research iv supporting academic industrial and clinical research on pscs and maximizing their potential and v inclusion of diverse stakeholders in the communication process on emerging psc based technologies including research towards clinical applications