Dragon09/odtu_chatbot huggingface dataset:
prenormative research on integrity assessment protocols of gas pipes repurposed to hydrogen and mitigation guidelines

transporting natural gas through pipelines has been shown to be safe and efficient for decades however decarbonizing the european industry and reducing carbon emissions will require a significant portion of the existing pipeline infrastructure to be used for transporting gaseous hydrogen under high pressure across the continent from production sites to end users the pipelines originally designed for natural gas are not considered h2ready and transmission system operators must demonstrate their compatibility with hydrogen the existing standards such as asme b3112 are often viewed as overly conservative and not conducive to the development of pure hydrogen networkspilgrhym is an ambitious rd project that seeks to develop a prenormative framework to support the development of a european standard the project aims to conduct a comprehensive testing program on smallscale laboratory specimens focusing on 8 base materials 2 welds and 2 heataffected zones that are representative of the eu gas grids these specimens will be selected after a thorough review by tsos to address safety concerns lack of regulations codes and standards as well as research gaps related to the compatibility of current pipelines with hydrogen pilgrhyms ultimate goal is to provide quantified data on more than 70 of the eu grid and refine existing norms codes and standards by reducing overconservatism and ensuring the safety and reliability of flaw assessment methodologiesthe results of pilgrhym will serve as the baseline for a harmonized european solution this project represents a significant step forward in the development of a comprehensive european standard for transporting hydrogen through pipelines and will be instrumental in the successful decarbonization of the european industry and reducing carbon emissions
root phenotyping integrated educational doctoral network

a deeper understanding of the interactions between soils and plants especially at the root zone where they take up waterand nutrients may support sustainable intensification of agricultural production research is indicating that a greaterunderstanding of roots and soil functions may lead to increases in crop yields reductions in greenhouse gas emissions fromsoils enhanced productivity in grasslands and reductions in fertilizer requirements to land however data gaps remain in ourunderstanding of how plant roots interact with their environment from a physiological and phenotypic perspective plantphenotyping has been described as the bottleneck to food security yet the real bottleneck to plant phenotyping is thought tobe image analysis and processing the challenge of ensuring food security provides the impetus for rooted rootphenotyping integrated educational doctoral network rooted will apply deep learning and artificialintelligence to speed up data generation in root phenotyping agriculture is increasingly using digital technologies butcurrently 44 of the european workforce do not have these basic skills this is a severe skills gap that europe needs toclose urgently to avoid economic downturn rooted will consolidate the complimentary expertise of an internationalinterdisciplinary multisectoral team to train a new generation of creative resilient adaptive multiskilled scientists capable ofinnovating the fields of plant and soil sciences to actively contribute to the goal of doubling food production in a sustainablemanner by 2050 soil health and food is one of the 5 mission areas for horizon europe and the findings from rootedwould be directly applicable to the eus green deal and a soil deal for europe rooted graduates will have a level of scientific communication and digital skills mastery that enables them to move straight into employment in agrifood businesses seed and breedingcompanies advisory and scientific roles
a gamechanging solarthermochemical heat storage and intensification technology for the process heat sector

this project proposes a gamechanging integrated technology of solar collectors and thermochemical energy storage tces systems this solution is primarily proposed to bring sustainability to the process heating sector which has been so far very challenging to decarbonize due to a lack of costeffective and reliable solutions besides this main feature the proposed technology has some distinguishing attributes that make it groundbreaking scientifically and very competitive technically these are 1 solving the technical challenges of tces systems namely material agglomeration over time and nonuniform heat distribution throughout the material within the reactor 2 integration of the solar collectors field and the tces system leading to lowered capital and maintenance costs and increased overall efficiency and 3 significant temperature lifting of the stored solar heat during the hydration phase of the thermochemical material enabling the system for process heating at much higher temperatures which are otherwise not possible by a solar energy system with main hypothesis that the uniform flow of reactive material can effectively be controlled and helpful for its agglomeration and nonuniform heat distribution prevention soltec aims at laying the first stone of research on this technology and pushing the edges of the stateoftheart through a developing the theoretical principles of solar heat capturingstoringintensification process b developing the optimal and compatible design of the collectors for this and c technoeconomic and environmental evaluation of the technology the project will develop the fundamental theories and methods to design optimize and test this innovatively operating solar system
highly redoxactive atomic centers in electrode materials for rechargeable batteries

lithiumion batteries are the stateoftheart electrochemical energy storage technology sodiumion batteries are about to become commercial and potassiumion batteries are attracting rapidly increasing interest all these alkaliion battery aib technologies especially the already or soontobe commercialized battery chemistries have one common characteristic making them so successful the use of insertiontype electrode materials these materials provide sufficient space in their crystal structure for the alkali ions to be reversibly inserted without causing substantial irreversible rearrangement however the fact that the ions can only occupy specific sites in the host lattice intrinsically limits the amount of ions that can be reversibly insertedthe aim of this project is the development of a new family of electrode materials for aibs which is characterized by an innovative storage mechanism this mechanism combines the benefits of a stable insertiontype host structure with an extended redox activity and additional available space for the alkaliion charge carriers resulting from the introduction of carefully selected atomic redox centres arcs based on own preliminary results and new yet to be developed suitable host matrices and arcs and their comprehensive investigation by highly complementary exin situ and operando characterization techniques to gain an indepth understanding of this new mechanism we will develop specific guidelines and design criteria for the realization of such novel materials these criteria and guidelines will be effectively evaluated by designing new materials which benefit of this new charge storage mechanism and thus enable longterm stable insertiontype aibs with enhanced energy and power densities moreover the results obtained will allow for an improved understanding of the redox behaviour of the highly active arcs at the atomic level a field of research that has been limited to theoretical studies so far
deep brain neuromodulation using temporal interference magnetic stimulation

five out of ten diseases leading to long termdisability are related to the brain including stroke depression or dementia despite tremendous progress in neurotechnology there is still no effective treatment option available for many brainrelated disorders a very promising approach to treat brain disorders uses transcranial electric or magnetic stimulation testms to directly influence brain activity related to specific symptoms however these methods are limited in their spatial resolution specificity and ability to reach deep brain areas the aim of the proposed project is to develop a technical and experimental proofofconcept for a new noninvasive tool that allows for millimeter and millisecondprecise modulation of neural activity in superficial and deep areas of the human brain capitalizing on temporal interference effects the device will apply high carrier frequency magnetic fields through a pair of coils by modulating their relative phase the combined fields will induce a locally amplitudemodulated electric field in the brain as neural tissue is insensitive to unmodulated highfrequency fields 1khz but responds to lowfrequency amplitudemodulated fields only brain regions will be stimulated where the combined field is amplitudemodulated building on the resulting versatility of stimulation frequencies and waveforms we aim at providing proof for celltype specificity of such temporal interference magnetic stimulation tims moreover we aim at providing proof for the feasibility of targeting neural activity at millisecondtomillisecond precision availability of such device offering high spatial resolution depth selectivity steerability as well as closedloopcompatibility and celltype specificity would mark a major breakthrough for clinical neuroscience together with two partners from industry and a partner for technology transfer we strive for fast translation of expected research results into innovative products
bauhaus of the seas sails

the vision of the boss project is to demonstrate and archive solutions for climate neutrality with a particular focus on coastal cities as an interface to healthy seas ocean and water bodies envisioning a new triangle of sustainability inclusion and design focused on the most important global natural space the bos will offer opportunities to engage with communities for an environmentally sustainable socially fair and aesthetically appealing transition seven lighthouse demonstrators located in four different regions and aquatic ecosystems in portugal estuary italy lagoon and gulf swedengermany strait north sea river and the netherlandsbelgium delta will showcase the transformational and uptake impact at the eu level serving as lighthouse pilots for the implementation of horizon europe mission objectives and showcase innovative solutions the seven pilots will all provide tangible examples of missionoriented approaches that are impactful measurable and targeted the action plan includes the deployment of drops in all pilots designed to generate ripple effects at the local demonstrator level but then also at the cityregion levels demonstrating effects of scale and at a broader level demonstrating the replication the boss therefore introduces an ecocentric narrative both cosmopolitan and rooted in naturebased solutions plural and testimonial proposing to apply a design approach to complex sociotechnicalecological and morethananthropocentric problems an agenda that moves from fixing to caring from growth to nurture from certainty to contingency will enable designers architects and engineers to think about assemblages instead of systems and change the outcome from extinction to precarious flourishing the design of these interactions generates the emergence of new aesthetics and most decisively a critical awareness of the history contemporary and future designing beyond humans as a way to sustain our future
enzymatic piezoelectric composites to regenerate redoxcofactors driven by mechanical sources

the costefficient production of sustainably derived biochemicals and biofuels is a critical goal of modern biotechnology redoxbiosynthetic pathways are fundamental in chemical manufacturing for establishing a biobased economy the sustainable regeneration and recycling of redox cofactors is a prerequisite for the viable industrial exploitation of many described redoxbiosynthetic pathways these boundaries hamper the employment of cofactordependent biotransformations at largescale production processes to overcome these limitations the main objective of this project piezozymes pushes the forefront of technology pursuing novel biotechnological tools aimed at the efficient regeneration of redox cofactors powered by mechanical sources such progress will bring several advantages over the current cofactorregeneration systems where the traditionally employed biochemical electrochemical and photonic sources will be replaced by mechanical ones the resulting technology of this project will have valuable social impact paving new pathways for the costefficient exploitation of cofactordependent enzymes as economically suitable biocatalysts in a plethora of industrial catalytic biotransformations
demonstration of digital twins for a green steel value chain

in context of the transition to lowcarbon green and sustainable steel production in europe disruptive technologies to reduce the environmental footprint as close to zero as possible seamless digitalisation of production processes and skilled people to codesign and understand the transformation process are necessary digrees will address these needs by implementing an integrated digitalisation approach across the steel value chain enabling better use of process data collected and ensuring the involvement of human experience for easier industrial integration the aim of digrees is to develop a userfriendly digital platform for networked production based on novel and soft sensors and related approaches and models to support efficient feedstock verification and realtime control of electric arc furnace crude steel production increasing process yield while improving the quality of intermediate and final steel products in this context the potential of artificial intelligence techniques will be fully exploited to support the optimal use of industrial data and different scenarios specific to each use case will be modelled the digital platform will be implemented and verified in industrial process lines of the three use cases scrapsecondary raw material verification optimisation of the electric arc furnace processes and optimisation of the levelling of steel sheets digrees aims to improve the quality of crude steel and finished products optimize scrap usage and improve energy efficiency in the steel production process digrees has the potential to save up to 800 million in costs annually and reduce co2 emissions from the steelmaking industry by up to 6 million tonnes per year
riskbased approach for the protection of public spaces in european cities

over the past decades europe has experienced several terrorist attacks proving that this threat is still real and serious while perpetrators are finding new methods to penetrate current security measures although grave attacks have so far been rather infrequent it is still a reality that eu citizens may be suddenly caught up in a terrorist incident while at the stadium shopping in a mall commuting visiting a cultural venue or in any other public space besides more terrorist attacks are associated with lower levels of life satisfaction and happiness among the eu population one in five people in the eu are indeed very worried about a terrorist attack in the next 12 months terrorist attacks also lower eu citizens trust in fellow citizens national political legal and police institutionssafecities aims to support excellence in the protection of public spaces by delivering and demonstrating a security and vulnerability assessment framework empowered by a decisionsupport platform for its implementation in 4 usecases across 5 eu countries this will allow for simulation of complex scenarios crowd behaviour and attacks in any space within a realistic virtual 3d environment enabling endusers to perform comprehensive and dynamic risk and vulnerability assessments of the site investigated to identify potential vulnerabilities against a wide number of threats and support the full engagement and cooperation of public and private actors including citizens into the elaboration of strategies to make public spaces secure while preserving their open naturethe consortium brings together 17 partners from 9 countries italy cyprus netherlands greece poland uk belgium finland slovenia to effectively carry out the 32 months project the project team includes local and regional authorities police authorities first responders organizations rtos and academia cso security industry cluster association and hightech smes specialised in security
the impact of human aged bone marrow niche on human hematopoietic stem cell function

in humans aging of the hematopoietic system is associated with anaemia impaired immune responses and increased frequency of myeloid malignancies the hematopoietic system is maintained by hematopoietic stem cells hscs hscs reside in the bone marrow bm within specialized niches where they selfrenew and differentiate to produce all blood and immune cells in the clinical setting of bm transplantation hscs from older donors result in a reduced transplantation success with a worse level of engraftment and higher overall mortality this demonstrates that there is a reduction in the function of aged human hscs hhscs causes of this impaired hhsc function with age still remain unclear therefore it is of great importance to uncover and subsequently target factors that contribute to hhsc aging in order to attenuate impaired haematopoiesis in the elderly due to the lack of meaningful human bm hbm niche models in the aging field the current understanding of how extrinsic changes stemming from the aged hbm niche contribute to the aging of hhsc is far less advanced compared to the knowledge of the contribution of cellintrinsic changes thus this proposal focuses on providing a significant understanding of ageassociated changes within the hbm niche and their contribution to the aging of hhscs using an agingcentred hbm niche model transplantation of young bm hhscs into this advanced niche model revealed that an aged hbm niche confers aging on young hhscs to this end the target of the proposal is to address the following questionsihow does aging affect the cellular and molecular composition of the hbm nicheiito which extent does an aged hbm niche affect aging of hhscsiiiwhat are the underlying mechanisms that confer an agelike function on hhscsmanage hsc addresses both technological and conceptual challenges in studying the role of the hbm niche in regulating hhsc function in the context of normal hematopoiesis and aging
integrative profiling and engineering of clonal cancer cell behaviours from the tissue level down to the molecular scale

clonal evolution in tumours the process by which cancer cells expand diversify and are selected is a major determinant of tumour growth and response to therapy how the coexistence of diverse cancer cell clones shape tumour development is a fundamental question that remains open in part because of limitations on existing experimental platforms and analytical frameworks our expertise inferring multicellular behaviours within tissue microenvironments together with recent advances in imaging assay automation and cell engineering timely place us in an excellent position to profile and engineer clonal interactions within tumours from the tissue level down to the molecular scale which enables targeting this important question with unprecedented throughput and spatial resolution in spaceclones we aim to 1 characterize clonal interactions in genetically engineered tumours at sub100 nm resolution 2 characterize clonal signatures under metabolically defined environmental conditions and 3 examine the cell state of engineered clonal spatial patterns to overcome a variety of challenges to understanding molecular and cellular mechanisms of clonal behaviours in tumours i have designed a groundbreaking approach that combines highlymultiplexed imaging in vitro and in vivo tumour models cell engineering superresolution microscopy combinatorial lowvolume liquid handling and algorithms for deconstruction of spatial patterns altogether spaceclones will exemplify how to imply causality on the emergence of clonal spatial patterns in tumours having farreaching implications for the study of any other multicellular system ultimately a deeper understanding of clonal evolution will contribute in the design of more effective cancer therapies and tools to predict clinical outcomes
chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuits

separating enantiomers is crucial to produce bioactive molecules eg in earlyphase drug discovery chiralforce aims at a radically new strategy to separate enantiometers on chip using chiral optical forces at siliconbased integrated waveguides the present solution of chiral chromatography for this multibillion market is slow and cumbersome since it requires tailored chemistry for each chiral compound and relies on large and expensive separation columns instead chiralforce envisions cmlength optical circuits integrated with microfluidics for extremely quick tuneable and cheap enantiomeric separation the underlying mechanism relies on optical forces that are enantioselective due to interaction of spinproperties of the optical field with the chiral optical polarizability of matter these chiral optical forces can be tailored well beyond the possibilities of freespace chiral light through nanophotonic design of strongly confined modes flowing analyte in microfluidic channels along cmlength laserdriven will then result in enantioseparationthe approach to reach our main objectives relies on three main consortium strengths first we will design and synthesize chiral molecules and nanoparticles that will allow us to explore chiral forces regardless of how the chiral polarizability of matter is tuned by the size shape and inbuilt spectroscopic resonances next we will establish the general framework of chiral optical forces on nanoparticles and molecules in liquid environments leveraging our strength in nanophotonic theory design and experiment on chiralspinproperties of electromagnetic fields finally we will leverage our experience in nanotechnology to fabricate siliconbased photonic integrated circuits integrated with microfluidics to demonstrate enantiomer separation