Dragon09/odtu_chatbot huggingface dataset:
epilepsy treatment using neuromodulation by noninvasive temporal interference stimulation

epilepsy is a brain disorder characterized by sporadic debilitating seizures and declines in mental health available therapies suffer from drawbacks and are not suitable for all patients the medical needs in epilepsy encapsulate those for clinically managing brain health in general ie the need for precision personalized nonsystemic and safer therapies potential innovative solutions are available from advances in technology but will require multidisciplinary teams which bridge between engineering and clinical neurologythe main objective of the emuniti project is to develop a breakthrough noninvasive personalized brain stimulation device for epilepsy patients i as a diagnostic for seizure localization which can guide subsequent surgical resection and ii as a therapy akin to immunizing the patient against seizures the device is based on temporal interference ti of electrical signals delivered from positions around the scalp the project will be led by adam williamson who is a former recipient of erc starting and proofofconcept grants and has ip for the technology his lab is at the interface between stateofthe art engineering and neurology and is based in a major european centre for clinical research on epilepsy in marseille france his lab has already demonstrated in a pilot study of epilepsy patients that ti can block seizureprovoking brain activitythe project includes three work packages wps wp1 focuses on optimizing ti stimulation at the engineering level and establishing a novel form of ti in multipolar ti mti wp2 will evaluate mti in epilepsy patients for seizure localization and for therapeutic intervention with the potential to create brain seizure immunity through repeated mti wp3 administers the project and delivers the main outcome a clinical prototype with closedloop stimulation combining mti and intelligent software the successful outcome is anticipated to lead to other applications for ti in brain health
metabolic regulation of cell cleavages in early embryogenesis

multicellular animals development begins with a sequence of rapid cell cycles and divisions named cleavages leading to the generation of a large pool of cells from which the embryo develops while there are several speciesspecific types of cleavages the underlying processes of cellcycle and cytokinesis involving characteristic largescale cytoskeletal reorganizations are well conserved yet how these processes integrate cellintrinsic and extrinsic signals adapting to the rapidly changing environment of the developing embryo remains largely unknown an emerging concept implies cell metabolism as an important factor regulating cytoskeletal elements and hence cellular function here i test the hypothesis that during cleavages specific metabolic elements play an essential role in regulating the cytoskeletonto address this hypothesis i developed an innovative fluxomics approach for analyzing wholeembryo metabolism combining metabolomics transcriptomic and realtime bioenergetics measurements in two different embryonic cleavage pattern models ascidians and zebrafish by combining the heisenberg groups expertise in biomechanics and my expertise in metabolism i will follow three main lines of research based on the wholeembryo fluxomics data 1 characterizing the spatiotemporal metabolic activity in the cleaving embryo 2 analyzing the function of specific metabolic elements in cytoskeleton regulation during cleavages and 3 determining the extrinsic factors temperature and oxygen levels affecting the mechanometabolic reactions during cleavages i expect these findings to provide insight into mechanometabolic mechanisms that will advance our understanding of embryonic development and shed light on diseaserelated processes where metabolism and cell division are highly interconnected such as cancer
scientific exchange to assess quality and risks of foods obtained by novel processing and packaging technologies

the goal of sequr food is to build an international scientific network including researchers from eu and south america that will work on the development of novel food processing technologies ie uv treatment cold plasma processing nanoemulsification freeze concentration and drying andor active bioactive packaging ie bacterial cellulose antibacterial paper etc to obtain safe products for the eu market with higher shelflife and high nutritional and functional properties this includes optimization of the novel food processing technologies nutritional and risk assessment of these technologies and obtained products as novel foods within efsas framework and documenting their health claims if relevant to achieve this objective a consortium of 5 universities from eu greece poland romania and spain with expertise in all the aspects of eu risk assessment 1 plantbased products processing company based in poland together with 1 university and 1 research institute from south america colombia with extended expertise in novel food processing techniques will work on a variety of case studies spread across several novel food processing technologies and products relevant for colombia fruit passionfruit uchuva physalis peruviana l blueberries cold brewed coffee oat milk including oat grains and nuts needed for its production and high oleic palm oil as compared to olive oil these case studies will be a proof of concept for the holistic assessment of each technologyfoodstuff pair and will constitute the basis for further research but also for food processors the principal stakeholders of the project the activities proposed in sequr food are innovative in many aspects the most important innovation is the holistic approach of new food product development in terms of the complete physicochemical microbiological nutritional and functional properties but also sensory evaluation and multicultural consumer acceptance
multicore fiber applications and technologies

multicore fiber applications and technologies match is a doctoral training network proposed by a multidisciplinary and intersectoral consortium of international experts this network directs phd research toward multicore fibre mcf technology which is recognized as the leading solution for scaling future optical fibre communication networks towards emerging information capacities while offering the potential to lower costs reduce power consumption and significantly boost network capacity by over tenfold while remaining as compatible as possible with current infrastructure the match programme outlines a comprehensive set of research and training objectives tailored to 13 doctoral candidates dcs the cohort of dcs will be hosted by 16 partners 11 from academia and 5 from the industrial sector with exposure to cuttingedge optical fibre technologyphotonic device realizationcommunication system engineering and with training by leading fellows in mcf expertise worldwide the planned training activities of dcs include 32 secondments 7 minisymposiums 3 transferable skills workshops summer schools and tutorials among others in match program dcs will acquire expertise in diverse areas encompassing i design and fabrication of mcfs with transmission capacities surpassing the stateoftheart ii design and implementation of mcf components and subsystems with a focus on optical amplifiers and switches multiple frequency comb sources and parallelscalable signal processing architectures iii development and implementation of machine learning techniques for endtoend performance optimization of mcf networks and iv design and evaluation of coexistence of telecom and nontelecom signals in mcf networks by engaging the expertise of match academic and industrial partners dcs will acquire distinct skills and knowledge to transform them to globallyminded scientists and engineers who will help to shape europes ict future and societal wellbeing
the worlds first lowcost inovo sexing solution to finally end chick culling

omegga worlds first lowcost inovo sexing solution to finally end chick cullingin the egglaying hen industry over 7 billion dayold roosters are killed each year because male layer chickens neither lay eggs nor produce enough meat to be profitable omegga developed a costeffective noninvasive spectral imaging solution for automating sex detection of chicken embryos in the eggs to avoid the unethical practice of chick culling by enabling hatcheries to remove early male eggs from incubators and only hatch femalelayer chicks the omegga technology is based on absorption spectroscopy and tracks sex specific biological indicators proprietary method enabling costeffective noninvasive automated determination of an eggs sex the solution aligns with ethical practices supports sustainable farming and meets emerging regulatory requirements against male chick cullingour team of 9 entrepreneurs swhwbio engineers data scientists and veterinarian developed the technology and built tested a first small scale industrial prototype now we must create large scale prototypes for full automation and optimise classification algorithms to minimise costs for which we need eic support once implemented it will boost resource efficiency and animal welfare in the poultry industry
a new technology of insitu observation datasets to address climate change effects in hardtoreach forest areas

forests play a key role in the earth climate system as they cover about 30 of the land area in the last decade they absorbed more than 7 gt of co2 contributing to reduce global warming and to buffer and mitigate increasing climate variability the summers of 2018 and 2019 included some of the hottest and driest periods ever recorded globally however the extent and severity of their impact is unknown due to lack of a comprehensive monitoring network which generally does not include hardtoreach areas characterised by strong logistic limitations therefore novel technological solutions are urgently needed to monitor forest responses to climate change and related extreme events also in remote areasrecent advances in internet of things technology iot satellite iot connectivity and energy harvesting systems are opening unprecedented opportunities for the use of iot devices in standalone experimental setups in this context the aim of the remotrees project is to design and build an innovative autonomous insitu monitoring system designed for remote forest areas and providing data via satellite communication to a dedicated remotrees platform in this framework remotrees will integrate existing and novel earth observation eo data with insitu observations of essential climate variables ecvs fraction of absorbed photosynthetically active radiation leaf area index soil moisture biomass change and other key variables including eg stem growth stem moisture sap flow canopy transmittance besides air humidity and temperature remotrees will include study cases on interoperability with geoss global earth observation system of systems and on how insitu data can support an improved understanding of the climate variability impact on forests the reinforced insitu component will be beneficial for copernicus products validation and will enhance the assessment of climate change longterm mitigation and adaptation potential of forests towards novel insights for climatesmart forest management
spontaneous interfacial oxidant formation as a key driver for aerosol oxidation

aerosols and clouds are key players in tropospheric chemistry these tiny particles suspended in the air with a radius ranging from a few nanometres to tens of micrometres impact atmospheric composition represent one of the largest uncertainties in climatic projections and cause millions of deaths worldwide every year hence they have enormous societal and economic consequences nonetheless there is still a knowledge gap preventing us from describing the chemical evolution of aerosols and clouds during their atmospheric lifetime supported by preliminary experiments i therefore propose to unravel the impact of the spontaneous oxidant formation at the airliquid interface as a key driver for multiphase oxidation processeswater molecules in bulk liquid are stable and inert under ambient conditions in sharp contrast it was very recently shown that the local orientation of water molecules at an airwater interface induces an electric field that generates spontaneous radicals in micronsized droplets this production does not involve any catalysts such as light or heat it is an intrinsic property of the airwater interface and therefore potentially ubiquitous in the tropospherethis spontaneous interfacial oxidant formation has never been explored for its atmospheric significance therefore the sofa project aims to unravel the atmospheric importance of this interfacial dark chemistry if oxidants including oh radicals are in fact spontaneously produced at the airwater interface under atmospherically relevant concentrations this would profoundly challenge our understanding and description of atmospheric multiphase chemistry sofa will develop a novel strategy scaling up from laboratorybased measurements to fieldwork and modelling to assess the importance of this interfacial chemistry sofa will advance an entirely new perspective on how to address the multiphase oxidation capacity of the troposphere and will therefore have a wide impact
feeding resilience of odontocetes in the anthropocene

deepdiving toothed whales are megapredators that supposedly shape and maintain healthy marine ecosystems human activity is on the rise in these ecosystems due to deepsea fishing and mining which can alter the prey landscape of toothed whales and therefore negatively affect their fitness with potential trophic cascades on entire deepwater ecosystems to address such concerns models for population consequences of disturbance pcod have been developed linking disturbance to fitness of individual whales and entire populations while the robustness of these models relies on data of energy budgets from undisturbed individuals a shortage of related quantitative measures precludes the effective use of these models and hence the efficient conservation of these predators through front i propose to fill this important knowledge gap by applying an innovative combination of stateoftheart tagging technology and motion analysis to for the first time in deepdiving toothed whales i quantify finescale feeding behaviour and foraging effort and ii estimate overall energy requirements and hunting costs as a result front will generate novel data on baseline energy budgets that are crucial bioenergetic parameters for pcod models by informing these models front will be of direct relevance to the european unions eu marine strategy framework directive for maintaining healthy populations of these apex predators through the management of underwater anthropogenic disturbance
textom xray texture tomography as a tool to enable multiscale insitu imaging of the enthesis a biological hinge between bone and tendon

hierarchical structures are signature elements of many biological and technical materials the orientational distribution of their crystalline constituents the crystallographic texture is important for their mechanical properties resolving the local structure and orientation spatially while keeping a large field of view is an unsolved problem i will solve this by introducing texture tomography a new 3d xray diffraction imaging method the core of the textom project it will enable to study the enthesis the biological connection between tendon and bone and by insitu deformation and micromechanical modelling couple its hierarchical structure with the mechanical behaviour i will use the brilliance gain of 4th generation synchrotrons to develop texture tomography as a tool to image complex crystallographic textures in 3d and overcome the spatial resolution barriers of current approaches i will develop the reconstruction approach for the crystallographic texture and use it to image the whole enthesis structure with 100nm spatial resolution and with high energy xrays image the enthesis structure during insitu tensile deformation with m resolution at several load steps the unique combination of 3d texture information and loading will allow to build a micromechanical enthesis model the novelty lies in the structural 3d characterization of the enthesis under deformation this is enabled by the development of texture tomography to reconstruct the 3d textures which will be useful for many other scientific problems i will build an accurate micromechanical enthesis model and this will shed light on the unknown load transfer mechanism in the enthesis on the nano and crystal levelthe flexible opensource approach of textom will ensure adaptation for new users and scientific problems 4th generation synchrotrons will propel texture tomography to the forefront of biomaterials science revolutionizing our study of crystallographic textures
smart implants for life enrichment

noncommunicable diseases ncds eg osteoporosis osteoarthritis joint ligament wear frailty fractures and associated complications in elderly are a severe threat frequently leading to a permanent decline of the patients general health and autonomy ncd prevention is highly relevant to reduce the need for longterm care the economic burden is expected to increase by 65 from 2020 to 2040 with a strong negative impact on patients quality of life smile will provide a crosssectoral early risk detection methodology by holistic analysis of elderly patients health data cocreation with endusers and consideration of diverse needs mental and physical abilities living and socioeconomic conditions as well as lifesituation of older people are implemented this includes training and enhanced stream of information to patients and other stakeholders it will offer an aibased patient analysis incl integration of smart wearables and medical devices incl implants to support monitoring of general health status our approach will disrupt the cycle of frailty by minimizing physical decline and risk of refractures to enhance the ai functions new data sources will be established by instrumenting medical devices mainly implants to augment them into monitoring and actively supporting devices smile will 1 develop an integrated platform to collect centralize manage analyze and share multimorbid geriatric patient data using technology such as ai machine learning 2 establish a paneuropean bottomup model of good governance of health data being patientcentered and patientcontrolled in line with current regulations and 3 establish a solution driven by the needs of citizens and patients of old age smile will establish a new approach of outcomemonitoring to provide patient centered personalized and integrated treatment of elderly ncd patients to improve quality of life enable real empowerment and ease the financial burden in an ageing society
the first natural scientifically proven and sideeffect free formula for anemia treatment and prevention

we are an award winning femaleled deeptech startup after 10 years of focused research on how foods impact iron absorption in the body our multidisciplinary team of scientists and entrepreneurs founded fejuice in 2020 based out of serbia our team aims to commercialise the disruptive application of our discoveries a novel solution for the treatment and preventing of anemia anemia is a disorder in which the blood has a reduced ability to carry oxygen to body tissues due to a reduced number of red blood cells the most common type of anemia is irondeficiency anemia or ida a condition associated with fatigue lost productivity lost cognitive function and increased morbidity risks almost every woman has ida at least once during her life with 27 of the population worldwide or 21 billion people suffering from the condition we believe each individual should have access to natural and sideeffect free treatment and prevention solutions our mission is to create a healthier and happier world for the next generation through our natural scientifically proven dietary formula fejuice aims to capture the growing market emerging in the area of functional foods as consumers seek natural and scientifically proven solutions that are sideeffect free upon launch fejuice will disrupt the iron supplement market by effectively eliminating or greatly offsetting sideeffects patients experience during traditional treatment our 100 natural solution will work effectively for prevention and treatment of mild anemia caused by lower iron levels if consumed with most of our funds currently committed to product development activities the lump sum provided by the women techeu programme combined with the coaching and enhanced visibility will be fundamental to us overcoming our commercial challenges
promoting resilience to plant disease understanding vulnerability and adaptation to xylella fastidiosa

plant health is vital for sustainable development plant pathogens threaten economies food security and rural livelihoods existing plant disease research focuses on ecology epidemiology and economic losses this overlooks social questions such as what makes farmers vulnerable to plant disease and what enables them to adapt without this knowledge it is difficult to develop equitable solutions to manage plant disease during my msca fellowship i will work with the laboratory for the analysis of socialecological systems in a globalised world laseg at the autonomous university of barcelona working with experts on environmental governance and rural wellbeing i will develop a novel approach to understanding the political ecology of plant disease my empirical focus is xylella fastidiosa an invasive bacteria that is considered the most serious threat to eu plant health in generations i will conduct fieldwork in two regions of spain facing an outbreak of xf the balearic islands and the valencian community during preliminary research in these regions in 2019 and 2022 i built a team of stakeholders that includes farmers government officials agricultural cooperatives scientists and more i will 1 use qmethod to map stakeholder perspectives on xylella governance 2 interview farmers to understand xylellas impacts in terms of differential vulnerability and ability to adapt and 3 conduct participatory photovoice workshops to engage rural communities in envisioning possible rural futures for living with xylella through a sixmonth traineeship with the european food safety authority efsa my findings will feed into ongoing science and policy dialogues on xylella by foregrounding placebased knowledge my approach will help inform more equitable plant health policies specifically we will answer calls to merge topdown efforts to manage plant pathogens with bottomup approaches that take into account farmers lived experiences and realities