Dragon09/odtu_chatbot huggingface dataset:
puzzle cell nutshell waste for sustainable material solutions

in 2025 around 11 billion tonnes of plastic waste will pollute the environment therefore a circular economy with biotransformation and biodegradation of oilbased plastics is as crucial as implementing biobased and biodegradable materials transforming lignocellulosic waste biomass into commercially valuable green materials is an emerging and promising way to minimize waste substitute plastic and reduce our carbon footprint as a waste resource we suggest walnut shells in which we discovered the interlocked 3d puzzle cells the homogeneity the high surface area and the channels make these cells interesting for transformation into biodegradable bioplastic we plan to dissolve the walnut shells in deep eutectic solvent to separate the cells add water to regenerate lignin and recycle the solvent the result of this closed process circle is a nut slurry as a basis for our materials to tailor and functionalize the composite for different applications we propose to add bacterial cellulose pellicles a waste from kombucha fermentation or produced in bioreactors the pure cellulose fibrils with high tensile strength are an exciting counterpart to the high lignin content pressure optimised puzzle cells with different ratios of the two agriresidues we will tune the material properties for nutplastic and nutleather sustainable energy and resource efficient biodegradable nutmaterials with a low carbon and environmental footprint are envisaged for the packaging and textile sector the project activities comprise 1 development and characterisation of nutleather and nutplastic products at the demonstration level 2 life cycle analysis cost of goods and carbon footprint 3 define endusers market analysis potential industrial partner buisness plan and ip strategy we have a strong project team with highly motivated and experienced members with complimentary backgrounds and a solid wish to prove the puzzle cell performance in sustainable materials
birdshades business model validation and ipr strategy

birdshades is a female led startup which develops an invisible window film to save billions of birds worldwidewe have recently successfully produced our first large scale pilot line which we are going to sell in a pilot customer programmewe plan to validate our business model and to improve our ip strategy to ensure and pave they way that birdshades will become one of tomorrows cutting edge deep tech champions which protects biodiversity worldwide
industrial cluster flexibility platform for sustainable factories to reduce co2 emissions and to enable the energy transition

the flex4fact project aims to develop an endtoend ecosystem that takes a modular approach to enable flexible manufacturing in industry and create the conditions for the necessary energy transition in which all stakeholders can participate and benefit currently complex process industries and the segment of mixed clusters and distributed renewable energy flows are not covered indeed at least three key elements of the flex4fact approach differ from current offerings 1 enabling industrial flexibility through digital process twinning and machine learning techniques to address complex operational scenarios and exploit the full potential of the selected industrial cases
residual executive power rexpo eu institutional balance and regulatory patterns after the covid19 crisis

rexpo investigates shifts in eu regulatory practices following the covid19 pandemic to contrast the pandemic the eu has mobilised unconventional legal tools such as financial assistance cohesion policy or softlaw coordination which fundamentally deviate from the communitymethod as the traditional eu lawmaking process rexpo analyses the impact of this postpandemic landscape on eu governance its central research question asks how the eu response to the pandemic has changed the nature of eu regulation and how new regulatory practices have affected the eu institutional balance in general and eu executive power in particular the project focuses on the relationship between executive power and the unconventional regulatory instruments mobilised to face the crisis it resorts to four empirical casestudies encompassing the temporary recovery instrument nextgenerationeu the unemployment financing scheme sure the distribution of vaccines and softlaw coordination in the field of health policy as these tools are all steered by the commission rexpo argues that they have strengthened the commissions executive functions while moving away from the community method using a historical institutionalist lens rexpo defines this increase in the commissions executive power as residual because it emerged as a secondary result of choices necessary to fight the pandemic and not from an intentional attribution of competences by political leaders rexpo combines empirical and theoretical research and adopts an innovative interdisciplinary approach to shed light on the legal and political consequences of the pandemic for eu governance and eventually for its democratic legitimacy whereas scholarship has focused on the political impact of the crisis and on the legality of the measures adopted these interstitial institutional changes have passed unnoticed however precisely these changes can trigger a transformation of eu executive governance
joint understanding and analysis of clade i monkeypox epidemiology evolution and immunology in south kivu

we recently described the novel clade ib mpox virus from kamituga south kivu which fast spread in the region and severe symptoms are the reason for the emergency call for mpox research further information on its transmission origin adaptation the protective serological response from different population groups possibilities to improve frontline treatment and possibilities for early detection of the extent of the outbreak is urgently needed to combat the outbreak the research proposed here is in close collaboration with local researchers and authorities and linked with already established capacity building projects covering drc burundi rwanda and tanzania we aim to 1 determine the adaptation of the novel clade by performing onsite whole genome sequencing on a unique already available isolate collection covering the duration of the outbreak 2 identify the origin of this clade by investigating bush meat and hunters 3 investigate the importance of coinfections and the potential usefulness of realtime metagenomic sequencing treatment guidance 4 determine the extent of the outbreak by serological and pit latrine surveillance in the crossborder regions of drc burundi rwanda and tanzania and 5 determine the specific immunological response to the novel clade from selected populationswe are uniquely positioned to conduct the proposed research as we have the necessary technical skills and competences through ongoing activities all ethical permission are in place to investigate mpox as a disease x scenario and we have established collaboration with crossborder health authoritieswe expect to create knowledge on the evolution and epidemiology of the novel clade information on the expected immune response and novel methods to perform early warning surveillance and improved treatment including of secondary infections almost all data generation and analyses will be performed locally thus also ensuring capacity building for future epidemics
innovative biogeosourced reused and recycled products coupled with bimbased digital platform for very low carbon construction circular economy energy and resource efficiency

the built environment and related construction processes are together responsible for up to half of europes greenhouse gas emissions the circular principles can contribute in important ways to achieving the 2050 carbon neutrality target in addition to the zero emissions 2030 target inbuilt proposes and develops 1 a set of innovative design retrofit and construction techniques for both existing and new buildings based on the use andor reuse of locally sourced bio and geomaterials along with reused and recycled components coupled with 2 a digital platform as a multiobjective decisionsupport tool for the optimisation of the integration such materials in buildings this can build an integrated strategy in which sustainability and digitalization are embedded into the construction sector this set of products includes largedsized rammed earth blocks recycled fired and nonfired bricks withwithout biosourced insulation hybrid strawclay boards recycled concrete blocks prefabricated waste wood external and internal wall elements smart windows with recycled glass and biopur frames biobased prefabricated curtain walls recycled waste paper and textile fibre insulation mats biobased recycled insulation sheet panelsinfill and second life pv panels these solution techniques already validated at the lab scale and designed following circularity principles will be upscaled demonstrated and tested in real buildings and optimised using the digital platform in a solid lifecyclebased and social lca perspective a multidisciplinary consortium will support these objectives outcomes will positively impact i european competitiveness of the construction sector in the field of green construction technologies ii decarbonisation of the building stock iii increased digitalisation iv raise resilience thanks to circular economy resource efficiency ecodesign and digitization of the inbuilt innovative systems
reliable powerdown for industrial drives

rpodid reliable powerdown for industrial drives aims to develop an automated cloudless shortterm faultprediction for electric drives power modules and power devices that can be integrated into power convertersthereby electrical and mechanical faults of machines and of the power converters driving them will become predictable within a limited prediction horizon of 1224hthis will enable a powersaving shutdown of a larger number of production machines during idle times because a looming failure during the next poweron cycle can be reliably foreseenit will also enable reliable mitigation of dangerous faults in applications using modern powerdevices like siliconcarbide sic and iiivsemiconductor devices like galliumnitride gan
transformation scenarios for boosting organic farming and organic aquaculture towards the farmtofork targets

with the farmtofork strategy f2f the eu has set targets of reaching at least 25 of the eus agricultural land under organic farming and significantly increasing organic aquaculture by 2030 the overall objective of organictargets4eu project is to support the achievement of these targetsbased on an assessment of key drivers and lockins affecting the development of the organic sector the project will setup a multiactor process to create possible scenarios for reaching the targets the project is structured into two strands which run from start to finishproduction and markets the project will analyse where increases in organic farmland can be achieved and the socioeconomic impacts of these increases at the level of primary production value chains and markets the project will also provide evidence on the mechanisms that can drive demand for organic food and the impact of changing diets and food waste reduction on mitigating the reduced yields from organic productionknowledge and innovation the project will work towards an innovation ecosystem fit for achieving the f2f targets recognising that the scale of the expansion envisaged will require a transformational approach it will identify knowledge gaps and opportunities to strengthen advisory services it will build capacity and stimulate exchange of scientific and practiceoriented knowledge building on the core organic network it will increase and coordinate ri investment for organicorganictargets4eu will facilitate a multiactor policy dialogue to assess the feasibility of the organic f2f targets and develop policy recommendations for the cap eu organic regulation eu and national organic action plans horizon europe and horizontal legislation on inputs and public procurement the policy recommendations will cover shortterm options up to 2027 the next policy reform from 2028 onwards and a horizon scanning post 2030 for the whole next multiannual financial framework to 2034
an open innovation ecosystem for exploitation of materials for building envelopes towards zero energy buildings

building sector is responsible for 40 of energy consumption and 36 of co2 emissions in the eu as nzeb becomes the new standard the role of building materials and smart envelope systems is becoming more and more important exploit4innomat oitb will make available a highend open innovation testbed network for building envelopes including roofs and facades enabling the replication of prototypes in different buildings taking into consideration the tradeoffs between the three sustainability pillars the life cycle stages as well as their impacts enduser market needs for lowcost flexible on demand materialbased solutions which will be assessed through an extensive partnership knowledge on materials characterization and modelling monitoring and process control environmental and assessment regulatory and standardization social acceptance and innovation management realizing for nzeb solutions in order to achieve this target a wide range of expertise has been brought to the oitb covering fields such as open innovation testbeds for nano enabled cement non cement premixes and ceramics advanced coatings and glazing solutions loaded with aerogel fibers pcms and other nanomaterials providing multifunctional properties pilot lines for nanodispersion 3d printing and roboting spraying as well as a network of four real scale living laboratories for nzeb technologies evaluation will facilitate a realization tool for developing close to market technological solutions additionally a semiautomated tool combining bim analysis fast track modelling and simulation will make enable a digital tool for utilizing building blocks structural solar thermal and bipv in order to create a harmonized and aesthetically pleasing urban environment
resiliencecentric smart green networked eu inland waterways

renew represents a multidisciplinary group composed of 24 participants from 11 countries of the european union capable of playing a key role in supporting the transition of iwt to smart green sustainable and climateresilient sector to achieve this the project will build on previous results will capitalise on cooperation opportunities with ongoing projects and initiatives and will deliver 1an interdisciplinary iwt resilience and sustainability decisionsupport framework incorporating innovative models for iwt infrastructure networking interdependencies linking to probabilistic risk and safety analyses and resilience quantification resilience index supporting the identification of short and longterm measures that enhance resilience utilising soa building blocks from reference projects 2 targeted innovative infrastructure resilience and sustainability solutions building on autonomy developments and maturing green energy options 3 a green resilient iwt dataspace and generic digital twin providing primarily data sharing between infrastructure monitoring ris and traffic management and emergency systems and climate solutions 4four living labs designed to provide exemplars from a lls focusing on integrated iw and hinterland infrastructure genturban douro corridor netherlands eu network perspectives and a ll addressing specifically inland waterway resilience 5renew outreach and upscale activities designed to maximise impact pathways
masters of the stone the stonecutters workshops and the rise of the late antique epigraphical cultures thirdfifth century ad

the stonemasters project aims at exploring one of the most startling problems in the global history of research on collective memory and commemorative practices the transformation of roman imperial epigraphic traditions in the later 3rd c ad and the subsequent rise of the socalled epigraphic cultures of late antiquity the problem has been passionately debated since the 1980s but so far no definite conclusions have been reached in this project the pi argues that the main reason for the transformation is to be ascribed to the dissemination of changes in the elites approach to epigraphy by the workshops of stonecutters and mosaicists and that only a thorough study of workshops can provide us with a complete understanding of the processes underpinning this same transition so far epigraphists of the roman period have had few instruments to draw upon for the purposes of pursuing synthetic workshop studies and have been overwhelmingly captivated by other strands the quantitative research the study of the selfrepresentation the visibility of inscriptions and the viewers culture the pi maintains that a significant leap in our understanding is however attainable through the building of a highly regionalized networkstemma of workshops which will identify workshops of origin for all the inscriptions from the 3rd5th c and through applying the methodologies of workshop studies developed for other craftsmanships and periods in particular for early greek vase painters and for scribes and scriptoria which the pi will adapt to the needs of the graecoroman epigraphy assuming that these new methodological lenses will redefine the field and refocus our attention on the actual actors behind the production of epigraphy artisans and workshops as primary agents of toptobottom cultural transfer then we can anticipate an entire restructuring of our understanding of the way artisans disseminated elitist culture in the lower echelons of society
belight improving biomedical diagnosis through lightbased technologies and machine learning

photonics is crucial for maintaining and increasing the competitiveness of eu industry and lightbased instruments are fundamental for noninvasive diagnostics and treatment of diseases delivering huge economic benefits for national health systems artificial intelligence ai and machine learning ml have demonstrated their capability to classify and identify patterns in data achieving reliability levels that are comparable to those of experienced physicians to fully develop the potentials of these technologies belight will provide top level training to 11 researchers in photonic technologies multispectral imaging eyetracking optical coherence tomography multispectral optoacoustic tomography superresolution microscopy and optogenetics that will be complemented with aiml computational imaging and modelling a closetotheclinic approach will allow them to advance the field of biomedicine with the ultimate goal of improving the understanding diagnosis and treatment of diseases in 3 main research areas visual health cardiovascular health and analysis of cells and tissues related to parkinsons and rare diseases using superresolution microscopybelight brings together an interdisciplinary consortium of 7 top academic institutions 3 internationally recognized hospitals and an ecosystem of 7 private companies with complementary knowhow in photonics microscopy aiml medical instruments and clinical research to promote intersectoral synergies belights multiskill training program will provide the researchers with the complete set of skills that are nowadays key for their success in both academic and nonacademic sectors they will gain a broad understanding of how stateoftheart lightbased technologies work a solid knowledge of ml and data processing and will obtain experience in clinical and commercialization processes belight will open for them a wide range of highquality job opportunities
gut microbiotainduced tregs for inflammatoryboweldisease ibd immunotherapy miti2

our project focuses on the regulatory properties of a subset of microbiotaspecific tr1like regulatory t treg cells for which we have already shown an unprecedented association with the clinical outcome of patients in various inflammatory diseases for a therapeutic use in inflammatory bowel diseases ibd ibd is a disabling chronic inflammatory process that affects young individuals and causes many lifealtering symptoms and represents a risk factor for colon cancer existing treatments are complex with most people requiring lifelong medications as well as dietary and lifestyle modifications and some requiring surgery in this context the development of new therapeutic approaches appears essential and immunotherapy and cellbased therapy are particularly promising strategies for this diseaseteams from nantes have a strong expertise in the field of human immunology mucosal immunology and immunotherapeutic strategies applied to various pathological conditions including gut inflammatory diseases they recently identified a novel microbiotainduced treg subset associated with good prognosis in ibd patients thus representing a promising candidate for innovative immunotherapeutic approaches based on the limitation to develop immunotherapy approach for human diseases by using animal models due to immune system specificitiesdifferences and ethical considerations we opted for the development of an ex vivo human preclinical model that will reconstitute the physiological complexity of the human gut teams from strasbourg have a strong experience and already setup models of organoids in different pathological systems that will perfectly fit to be used as ex vivo preclinical models for this projectthis proposal aims thus at providing a preclinical package including i the proof of concept that a cellular immunotherapy using the identified tregs subset represents a treatment for ibds and ii the reglementary preclinical in vitro and in vivo toxicity
evaluating a new stool based qpcr for diagnosis of tuberculosis in children and people living with hiv

the covid19 pandemic had a devastating impact on tuberculosis tb control in 2020 the number of people newly diagnosed with tb decreased by 18 despite a rising global tb burden intensified efforts to improve tb case detection are critically needed especially in populations in whom bacteriological confirmation is suboptimal such as children and people living with hiv plhiv who have also been disproportionately affected by the pandemic the need for highly sensitive sputumfree diagnostic tools for tb has never been greaterstool4tb an edctp2 funded diagnostic trial began its activities in 2020 shortly after the onset of the covid19 pandemic the study aims to validate a novel quantitative pcr assay utilizing a stool homogenization and dna isolation method that yields a highly sensitive and specific detection of mycobacterium tuberculosis stool4tb is implemented in high tb hiv burden settings of mozambique eswatini and uganda under the hypothesis that it will contribute to narrow the large tb case detection gap by improving tb labconfirmation rates in children and plhiv while proving feasible and acceptable new evidence suggests that this platform has a higher sensitivity when compared to sputum culture and xpert ultra and could have an additive labconfirmation yield of up to 20 stool4tb is also evaluating the qpcr platform as a treatment monitoring tool this assay has the potential to be adapted to a poc diagnostic test which could be easily implemented in decentralized levels of caregiven the impact of the covid19 pandemic on tb notifications at the three participating sites and on several stool4tb core activities we request additional funding to finalize recruitment of participants and achieve the target sample size ensuring full execution of all projects objectives the observed upward trend in global tb burden makes the development of promising diagnostic tools such as this novel stoolbased qpcr more important than ever