Dragon09/odtu_chatbot huggingface dataset:
development of life changing drugs for patients suffering from severe and fatal neurological disorders

atmosr is a startup whose mission is to develop innovative therapeutic solutions for patients suffering from severe and often fatal disorders of the central nervous systemour company has established a technology in order to develop treatments for aggregate pathologies such as als kennedy disease multisystem atrophy parkinson huntington which represent a major health problem considering the high number of patients worldwide and the high unmet medical need the first disorder targeted by atmosr is congenital central hypoventilation syndrome cchs a rare genetic syndrome which presents as its main symptom severe periods of hypoventilation patients are kept alive thanks to mechanical ventilation administered through a tracheostomy our goal is to develop a drug that will be life changing for patients and their families liberating them from the machine lifting the vital risk and allowing them to live independentlyour team consists of multidisciplinary profiles with experience in both drug development particularly in the field of rare diseases and in business management as a spinoff of the french cchs patient organization we work in close cooperation with the international academic experts in cchs especially in france italy and isral we have identified a hit compound ats003 that is active in both in vitro and in vivo cchs robust models and we have optimized the compound thanks to a chemistry program in order to improve its efficiency and lower its toxicity for a better long term use tolerance we are starting regulatory preclinical work in 2023 with this new lead compound and have planned the first clinical trials by mid 2025 and an early drug access for patients in 2027in addition to cchs we have identified several disorders with similar protein aggregation mechanisms we plan to test and develop our lead compound for other more common disorders and the purpose of this project is to idententify the most promising one for our lead
upgrade team formation in game development

this project draws a pathway to understanding the game industrys team formation and collaboration process pursuing solutions to empower game creators to form collectives based on their team dynamics allowing creative talent to coordinate more efficiently the main objective is to create a methodology for helping game devs and game incubators to develop and foster more prosperous and diverse grassroots coalitions across geographic social and economic boundaries gathering knowledge on how game devs collaborate based on specific characteristics this study will provide a more precise quantifiable way to understand why each person teams with one another this research is added to the emerging literature on how game developers work together and which criteria lead to more successful teams disruptive mindsets and collaborative environments observing how teams collaborate and how algorithms can help teams better collaborate the research outcome is to create models to help developers connect more efficiently during game jams and incubation programs a method that facilitates and scales matchmaking can be groundbreaking for game creators the project gives reasons to expect development of a novel algorithmmediated matchmaking system for game developers which can further be developed as a startup
voices of resistance a global microhistorical approach to enslavement across the atlantic and indian ocean

historiography suggests that the different ways in which people were enslaved eg through war kidnapping debt birth mattered greatly for how they resisted and were treated under slavery these links remain largely unexplored but are vital to reunderstanding the history and present of slavery this project studies how responses to modes of enslavement impacted i slave trade patterns ii labelling and treatment and iii strategies of enslaved across the indian ocean indonesian archipelago and atlanticthe project employs a global microhistorical approach to study the uniquely detailed material from colonial court records containing voices of enslaved and other actors as witnesses victims or accused these provide a lens on modes of enslavement practices of slavery and strategies of enslaved that surface both transgressions and the considered normal creating multiplicities of views on circumstances and backgrounds indexation and proven qualitative methods are used to analyse the court records the rich and increasing digitized colonial archives allow for contextualization strategies and expanding on innovative digital research infrastructure globalisethe project team tackles key cases related to the key european empires portuguese spanish french english dutch fruitful team synergy is created by light collective efforts that allow connecting comparing and analyzing research results from the subprojects eg on the same groups of enslaved as balinese pulaya or malagasy as they occur in different case study regions and archives the project bridges historiographic gaps between the indian ocean and indonesian archipelago east and atlantic west it revisits our understanding of slavery by innovating debates on i the global context of nationalized narratives of slavery history ii the impact of enslavement in relation to different slavery regimes and iii the uniqueness of atlantic slavery and racialization
fuelling startup villages with circular bioeconomy strategies

foodcop is an innovative venture to enhance interregional collaboration among startup villages to ignite the transformation of food systems at the heart of this initiative lies the challenge of aligning diverse stakeholder interests and catalysing sustainable growth through the principles of the circular bioeconomy the project aims to deliver three main impacts establishing a robust collaborative framework fostering sustainable food system transformations and enhancing knowledge and awareness of circular bioeconomy solutions among rural innovators methodologically foodcop unfolds in 3 phases first it lays the groundwork by establishing a conceptual framework and stakeholder engagement drawing insights from best practices to shape a collaborative agenda and design pilot projects the subsequent phase transitions into developing a transformative community of practice cop emphasising resource optimisation collective learning and implementing cocreation methodologies to bolster innovation the final phase focuses on sustainability and resilience highlighting the role of foodcop ambassadors and leveraging dissemination and communication activities to share successes and insights foodcop comprises a diverse network of stakeholders including startup villages regional networks clusters smes research centres and knowledge and innovation communities standing uniquely positioned to drive this initiative with its comprehensive approach foodcop aims to revolutionise the food industrys innovation landscape and ensure its impacts resonate well beyond the projects lifetime the collaboration brings together a wealth of expertise and resources promising to create a sustainable and inclusive ecosystem that supports the transformation of food systems through circular bioeconomy principles foodcop will redefine the parameters of interregional collaboration making a significant contribution towards a sustainable resilient and innovative food industry
cooperative and interconnected green delivery solutions towards an era of optimized zero emission lastmile logistics

greenlog accelerates systemic changes in last mile delivery ecosystems for economically environmentally and socially sustainable city logistics the project establishes city platforms comprising of inclusive stakeholder urban living labs for nurturing social innovation designing and deploying innovative delivery solutions while allowing the most effective exchange of ideas the development of robust harmonized regulatory and policy frameworks and cooperative business models that build upon effective publicprivatesector collaboration and joint investments the greenlog approach provides an innovative simulation environment for scenario building combining different solutions that allow the integration of lastmile delivery interventions with the highest possible impact on environmental sustainability and traffic reduction while considering their financial viability on the operational level greenlog provides cargobike based innovations for sustainable microconsolidation design and deployments multimodal parcel deliveries integrating public transportation logistic as a service platforms for interconnected city logistics and automated delivery concepts with the use of autonomous vehicles and delivery droids the solutions are supported by interconnected city logistics dataspaces that feed dynamic services for proactive optimization of the ecosystem respecting the interests of consumers businesses and city stakeholders the approach is deployed and validated in five cities and areas athens barcelona flanders oxfordshire and ispra special focus is given on the transferability of the proposed innovation starting from three follower cities with high interests in tailoring and replicating the greenlog solutions and continuing with a paneuropean outreach with intensive transfearability accelaration actions setting the ground for the establishment of multiple city logistics urban living labs
electron beam emergent additive manufacturing

the objective of project is establishment of a new excellent centre for electron beam precision manufacturing ebeam centre with international research team led by an experienced researcher prof mh rmmeli era chair to help exploit the research potential of the use of electronbeams to fabricate and structure new materials at the atomistic level and to enhance performance in research innovation and education in nanotechnology as well as energy and environmental technologies and visibility of vsbtuo at international level the project is also aimed on implementation of structural changes in research environment and science management at vsbtuo initiated by era chair to develop a research environment that meets the highest international standard and on support of young researchers who will strengthen their creative and innovative potential via their engagement in the project and make use of the international dimension of the project for gaining independence and career development the ebeam project will have regional and national impacts in terms of research education and technology according to research and innovation smart specialization strategy
building a community of railway scientific researchers and academia for erju and enabling a network of phds academia teaming with industry

academics4rail is an stable and durable scientific community that in an organized way can share and exchange scientific knowledge with erju and errac this knowledge is shared at different levels strategic to concrete technical areas and for different purposes when it comes to the strategic level the scientific community intends to share knowledge with errac and erju with the purpose of optimise the program for railway research providing insights of fund use existing themes for research and scientific necessities for the future of european railways it also supports the methodology of program assessment using kpis and impact estimation towards the objectives set out in the erju masterplan finally the scientific community shares its knowledge about necessities of future phd funding with a relevant european and scientific weight in a more concrete technological domain the scientific community engages in specific themes creating 6 phd positions that will enlarge the knowledge in 6 specific areas and will enable the cooperation of academia with industry the areas are phd1 aerodynamics of freight trains phd2 electromagnetic compatibility phd3 additive manufacturing in wheel reprofiling phd4 digital communications for virtual coupling phd5 prognostics and health management approach for railway asset maintenance phd6 driving assistance
towards a world integrated and socioeconomically balanced european economic development scenario

the objective of the twin seeds project is to investigate changes in international trade and production patterns specifically in global value chains gvcs both those of a longerterm nature driven by the twin seeds technological developments and geopolitical changes and those that are taking place in the wake of the covid19 pandemic the project will examine the impacts of these changes on employment job quality social and regional cohesion on patterns of growth and competitiveness as well as their environmental implications the analysis will provide the basis to map out forwardlooking policy scenarios including trade and investment industrial regional educationtraining and social policies that allow europe to secure decent work and working conditions rapid progress towards resourceefficiency and decarbonisation security of supply for strategic goods and sustainable inclusive and competitive growth in the years to come the research will be based on a thorough multilevel global national regional sectoral firm level research framework relying on a mix of quantitative and qualitative methods on multidisciplinary knowledge international economists and trade policy experts regional economists international business and organisational experts political scientists and on an extensive stakeholder engagement
materials for a nextgeneration nanooptoelectromechanical systems

nanooptoelectromechanics noems is an emerging field with unparalleled prospects for the design of efficient and lowpower devices for ict however to capitalize noems potential a flexible and upscalable technology platform must be established preferably based on current microelectronic technologymagnific aims at filling this gap focusing on nanocrystalline silicon ncsi only recently used in noems with very promising results and its integration with columnar aluminium nitride indeed while ncsi is widely used in mems production the dynamics of such an optically and electrically active nanocrystalline material has barely been investigated leaving fundamental gaps in the understanding of the interplay between electrons photons and phononsin this context we propose an upscalable cost efficient room temperature and sicompatible nanooptoelectromechanical platform for powering efficient communications technologies the key challenge is to achieve a comprehensive understanding of the static and dynamic material properties and their interdependence in particular understanding the role of nanocrystallites and grain boundaries in absorption and in dissipation mechanisms at the nanoscale is crucial for energy efficiency and for reliable performance as they are intrinsically linked to losses and variabilitythe aimed platform will provide a coherent interface between rf electronics and telecomwavelength optics mediated by phonons able to provide different functionalities local oscillation frequency conversion modulation in highly compact energy efficient devicesthe project starts at trl3 achieved via two previous ec projects and brings the system to trl5 realizing devices and circuits suitably packaged and environmentally tested with rf frequencies in the 312 ghz range this will allow to cover a broad variety of ict applications including pervasive wireless networks 5g and beyond smart cities iot and satellite communications
largescale conservation of perishable foodstuffs in the low countries 16001800

in the early modern period largescale food conservation practices such as fermenting smoking and pickling were crucial for globalizing trade and increasing food security and thus for economic and demographic growth in europes cultural trading hubs in addition recent research indicates that domestic and trade practices like food conservation were key to the development of natural philosophical and chemical knowledge and vice versa yet we still know very little about how knowledge on early modern food conservation was produced adapted and circulated across these domains how can we retrieve and understand embodied practical historical knowledge through the history of early modern food conservation how did embodied practical knowledge of food conservation develop in conjunction with formalised scholarly knowledge who were the people who produced and circulated these two types of knowledge and to ensure food supply before the industrial revolution preservare to preserve answers these questions through case studies on 1 fermenting 2 smoking and 3 brining curing and pickling it employs a theoretical framework rooted in the history of science and a groundbreaking interdisciplinary approach that combines classical historical source interpretation with digital information extraction archaeological data analysis and physical reconstructions of early modern largescale food conservation practices addressing these questions is urgently needed for the development of the history of knowledge and is possible now because of recent developments in digitisation and information extraction and theoretical and methodological advances in historical research the project provides a history of early modern food conservation in the low countries in a global context plus a theoretical and methodological framework for the historical study of dispersed epistemic domains and the retrieval and analysis of embodied practical historical knowledge
not knowing in deep representation learning

machine learning and artificial intelligence techniques are progressing at a tremendous pace and impressive results appear across scientific fields however as machine learning models grow in capacity they become increasingly black box and it becomes harder for humans to reason about the patterns discovered by the machine a root cause of this difficulty is that most machine learning models can express the same pattern in infinitely many equally good ways within their internal representations of the world this is known as an identifiability problemtoday we lack a general solution to identifiability problems and either give up on understanding the patterns discovered by the machine or reduce model complexity to lessen the problem the latter also reduces the fidelity and applicability of the model noknow rephrase the question of identifiability to be concerned with tasks solved by the representation rather than the representation itself using tools from differential geometry and bayesian inference we develop the theoretical tools to ensure that tasks solved in the representation have an identifiable outcome even if the representations themselves are not identifiableto turn theory into practice we develop stateoftheart algorithms for assessing the uncertainty of learned representations in order to indirectly estimate the topology of the representation manifold we further develop novel highfidelity predictive models that have identifiable outcomes when trained on learned representationsnoknow provides the fundamental tools needed to engage with learned representations to guarantee identifiable outcomes this in turn increase trust in findings as they are not dependent on arbitrariness in learned representations as society increasingly automates decisions this trust in machine learning becomes ever more important
photoactive metalorganic framework for solardriven atmospheric water harvesting in arid climates

atmospheric water harvesting awh using solar energy has gained significant attention however its application in arid climates poses challenges due to low relative humidity rh and reduced efficiency of conventional sorbents metalorganic frameworks mofs are a class of porous materials with an engineerable structure that have the ability to capture water even at very low rh usually the combination of photothermal materials with mofs is used to desorb water sorbed by mofs one of the challenges of this method is the reduction of mof sorption capacity which is very unfavorable especially in arid climates reducing the performance of sorbents in arid climates due to the blocking of sorption sites by dust is another challenge that has received little attention so far to address these challenges this study evaluates the synthesis of a unique waterstable mof with photothermal and photocatalytic photoactive properties pamof in addition to high water affinity phthalocyanine and porphyrin ligands decorated with ti and cu ions along with yttrium y and erbium er clusters are considered as promising candidates molecular modeling using density functional theory dft will be conducted to guide the synthesis process followed by experimental synthesis and characterization subsequently the samples will be evaluated in an awh device to assess shortterm efficiency and longterm maintenance in real conditions in addition to harnessing natural solar energy the awh experiments will involve the utilization of a custommade solar simulator the sawh device will be evaluated across a range of rhs spanning from 10 to 90 while considering the presence of artificial dust through comparative analysis of existing research and with the aim of enhancing previously studied systems this project endeavors to attain a daily water evaporation rate surpassing 4 kgwaterkgpamof under 1 sun and rh30
ferry demonstrator for the switch to safe use of sustainable climate neutral fuels in adriatic zero emission adriatic ship zeas

the main aim of the project is to contribute to accelerating the shift to safe use of sustainable climate neutral fuels in waterborne transport through a full scale on board operational demonstration of a new system powered by hydrogen fuel cells with maritime applications an international consortium of topnotch entities covering the whole innovation value chain will develop validate and demonstrate a new zero emission passenger ship powered by hydrogen and the associated hydrogen distribution storage and bunkering solution the ship will be specifically designed to operate in the adriatic sea which is known for its pristine environment and sensitive marine ecosystems the commissioning and validation in the operational environment through sea trials will be performed to ensure compliance with certification authorities emissions assessment environmental performance studies risk and safety assessments will be performed on the new system advanced digital technologies including digital twin for monitoring control and simulation and predictive maintenance solution enhanced with augmented reality systems will also be developed documented tested and optimized during the project for ship owners operators shipyards and associated engineering firms finally a detailed feasibility assessment and business planning will be developed to establish commercialisation and scalability opportunities a successful realisation of the project will facilitate the wider adoption of sustainable climate neutral fuels within the european maritime transport sector in line with the green deal objectives contributing to its efficiency safety resilience and international competitiveness