Dragon09/odtu_chatbot huggingface dataset:
from conformal symmetries and integrability to the electronion collider

the primary goal of this research proposal is to lay the foundations for precision predictions for the physics program in deepinelastic scattering dis at the electronioncollider eic the commissioning of the eic will open a new era in the exploration of the strong interaction physics and the hadron structure at an unprecedented level of detail this is expected to lead among other results to the clarification of the proton spin puzzle the crucial ingredient for the success of this undertaking is the ability to confront experimental data to precise predictions for a those benchmark processes which will form a core part of the eic physics program inclusive leptonhadron dis including polarized beams dis charm or bottomquark production deeplyvirtual compton scattering in offforward kinematics capitalizing on recent theoretical advances driven to a significant extent by the work of the pi this proposal outlines a challenging and ambitious program to advance quantum chromodynamics qcd perturbation theory in order to achieve a theoretical description of the key observables at the eic at percent level precision the proposal puts forward a novel research methodology based on the systematic use of conformal symmetry and integrability as realized in gauge theories with extended supersymmetry such as the n4 supersymmetric yangmills sym theory to reveal structural information on qcd results observables in leptonhadron dis are particularly well suited to turn the connections between n4 sym theory and qcd into a powerful computational tool which leads to significant simplifications due to the hidden symmetries underlying integrable systems progress in this direction will open new avenues for research and will establish new bridges between the scientific communities in phenomenology and mathematical physics the new qcd results will be used in the course of the project to explore precision phenomenology at the eic
vibrational microrobots in viscoelastic biological tissues

wireless microrobots hold great potential for minimallyinvasive medicine since they may allow for targeted drug delivery in vivo sensing stimulation and even new surgical procedures however the biggest hurdle for biomedical applications is the penetration of real biological media for instance mucus vitreous blood clots and tumour tissues most current micronanorobots can propel in water however the same propulsion mechanisms do not readily transfer to viscoelastic biological media one major bottleneck is that it is not possible to exert enough force for propulsion in a system that could one day also accommodate a human the overall goal of this proposal is to develop vibrational microdevices that can actively propel and wirelessly sense in viscoelastic biological tissues the excited mechanical vibration is coupled with the frequencydependent fluidic rheology to increase the energy release rate to reduce the penetration force needed for tissue rupture and thus to facilitate an easier penetration of the tissues we will investigate the fundamental mechanisms of propulsion at low reynolds number in viscoelastic materials the microrheology of the biological fluids will be measured and modelled and it will allow us to optimize the shape and gait of the microrobot to exploit the complex rheological properties of biological tissues and generate propulsion the proposed work will also advance threedimensional fabrication technologies for asymmetric micronanostructures as key elements to interact with tissues to facilitate efficient locomotion we will also develop novel sensing methods for in vivo sensing and localization of the microdevices our research will lead to a new class of microrobots the vibebots that will be able to actively penetrate real tissues and open up outstanding opportunities for useful biomedical applications
advanced software tools for javascript developers

modern webbased software uses the javascript programming language together with the nodejs framework and extensively rely on freely available thirdparty software libraries that provide common functionality these libraries are continuously improved and new versions are released frequently this massive reuse of libraries is essential to the productivity of software developers however the dependence on other peoples libraries opens the door to security vulnerabilities and programming errors that may have severe consequences to the applications and end users with current technology it is extremely difficult for the software developers to adapt programs to breaking changes in libraries avoid unintended breaking changes and investigate the possible consequences of security vulnerabilities in librariesthe erc project paw has delivered a range of novel program analysis techniques that can help javascript programmers by automating these complex tasks the analysis techniques have been implemented as prototype software tools and preliminary experimental results have demonstrated that they are effective on realworld software the proposed project pawtools aims to explore the commercial and innovative aspects of these scientific results by further developing the prototype tools into commercial products performing more extensive evaluations of their effectiveness and engaging with potential users and industry partners
developmentally programmed pediatric sarcomas a versatile platform for drug discovery and molecular precision medicine

pediatric sarcomas account for 20 of childhood cancers they have disappointing survival rates with very little therapeutic progress over the last three decades we clearly have to rethink the science and find new ways to tackle these devastating tumors i propose that new cellular models are needed that account for the developmental origins of pediatric sarcoma in order to accelerate drug discovery and molecular precision medicinefocusing on ewing sarcoma which is a developmental cancer caused by a known fusion oncogene expressed in unknown cellsoforigin we will pursue a build it to understand it approach and construct in vitro and in vivo tumor models starting from human pluripotent stem cells hpscs we will validate these models against our singlecell and spatial maps of ewing sarcoma tumors and we will pursue initial applications in academic drug discovery targeting the regulatory programs of ewing sarcoma cells metabolic dependencies of the tumor microenvironment and developmentally programmed tumors in their in vivo contextto build ewing sarcoma models in a molecular defined manner we will map oncogenecompetent cell states by inducing ewsfli1 expression in hpscbased models of human development aim 1 we will create supportive tumor microenvironments by 3d differentiation and crispr screening in stromal cells aim 2 finally we will evaluate the ability of in vitro models to form tumors in mice and we will pursue full in vivo modeling of ewing sarcoma using genetically engineered teratomas aim 3 compared to patientderived xenografts organoids or cell lines our approach captures early events of tumorigenesis providing complementary in vitro and in vivo models of ewing sarcoma for biomedical and translational research this approach will generalize to other tumor types as it takes the concept of developmental cancers seriously and operationalizes it using cellular programming and highthroughput functional biology
twophoton excited nearinfrared emissive multifunctional gold nanoclusters for imaging and photothermal treatment for alzheimers disease

neurodegenerative diseases are a global epidemic with significant health social and economic implications and despite intensive research there is still no cure for them alzheimers disease ad is the most prevalent neurological disorder having symptoms of the progressive memory loss neuronal cell death loss of immune response and cognitive function eventually leading to patient death amyloid a protein is the main neuropathic agent in ad and aggregation of a plaques are found in the brain tissue of patients suffering from this disease the application of nanomaterials has emerged as a new frontier in nanomedicine for the treatment of ad among various nanomaterials ultrasmall gold nanoclusters au ncs may serve as a promising choice for the diagnosis and treatment of ad from the very early stage which can be well justified by the advantages of au ncs in terms of their diverse physicochemical properties biocompatibility and biodistribution high surface to volume ratio ease for functionalisation and drug loading bloodbrain barrier bbb translocation and the possibility of twophoton excitation the main objective of our research is to advance in the development of new biocompatible multifunctional nanomaterials for the detection of amyloids with high spatial resolution and the subsequent degradation of amyloid aggregates using a noninvasive approach in this regard the blinking and nonlinear optical properties of the au ncs enable its potential for nanoscopic imaging of amyloid and twophoton photothermal ablation of amyloid aggregates another advantage of the proposed multifunctional nanomaterials is that they can also be used as drug delivery vehicles to penetrate the cell membrane and bbb to deliver antiamyloid drugs that exhibit effective imagingguided photothermal efficacy this research will use stateoftheart technology to develop a multifunctional phototheranostic nanomedicine for the detection and treatment of amyloid diseases
accelerating datafication for support of eu health priorities greening of biobanks and integrated approach to one health

since its creation the biobanking and biomolecular resources research infrastructure european research infrastructure consortium bbmrieric has made a remarkable contribution to european and international cuttingedge research as one of the largest ri for health research and in life sciences in europe 2023 marking its 10year anniversary bbmrieric is facing a unique moment to look into the longterm future and to develop its strategy for the next decade to ensure longterm sustainability the evolvebbmri project aims to further develop bbmrieric for the benefit of its scientific communities and users increase its capacity to serve eu policy priorities and further deepen its collaboration with industry the project is structured in four thematic pillars 1 acceleration of datafication of biobanks and biomolecular resources to enable reproducible advanced medical research in support of eu health priorities 2 teaming with industry towards greener biobanking 3 longterm sustainability measures for bbmri addressing also ri landscape gaps and 4 strengthened approach for career paths training and outreach activities to maximise impact the project will ensure the implementation of specific results on 6 key target groups a scientific community universities hospitals research institutes b bbmrieric national nodes biobanks in europe and beyond c industry and private foundations d policy and decisionmakers at national and european levels e european and international networks and f donors patients and citizensevolvebbmri activities and outputs within its four pillars will increase the longterm sustainability of bbmrieric and will thus contribute to a better structured and strengthened european research infrastructure landscape ultimately the project will contribute to increase the scientific excellence to better tackle scientific and societal challenges and to expand and secure global competitiveness of the european research area
color in a new light origins trade and cultural significance of ancient pigments

the ancient world was fascinated by color people processed certain raw materials to use them as pigments their material qualities and provenance mattered yet little is known about where these materials came from some might have been broadly available others rare and traded far along the way from resource to artwork much is still unknown a plethora of mineral pigments was used in the past materials were processed ranging from powdered cinnabar to pyrotechnological multicomponent materials they came together to color walls and sculpture alike and now enable the understanding of interaction across production technologies trade networks and cultural relations in a new way so far identifying the provenance of pigments relies on metal reference but metals and pigments are not the same it is thus essential to develop a pigmentspecific reference database paired with a proper toolset to push this new avenue in archaeological science to its full potential among other pigments egyptian blue serves as a cornerstone indicator of crosscraft interaction between metal and glass work hue probes material provenance and production technology by looking at the mediterranean from the bronze age to the roman period until the 1st century bcad a time of great political reorganization and significant change in the organization of pigment production hue analyzes raw and processed pigments from original artifacts workshops and trade nodes to bridge the gap from resource market and workshop to art the results are not only relevant for polychromy research but also for an archaeological evaluation of workshops discussion of market and trade network theories and peopleenvironment interaction the pi has already shown the significance of this approach in pilot studies supported by a network of international specialists new light will shine on ancient pigments to reveal the cultural significance of color in economic and technological developments
understanding how long noncoding rnas adapt the adipocyte for specialised lipid storage and breakdown

energy is stored in adipocytes as a large uniocular lipid droplet which can be broken down into fatty acids fas and released into the circulation when needed this specialised lipid storage and breakdown requires dynamic organisation of metabolic enzymes and cofactors around the large lipid droplet for metabolic homeostasis in obesity the adipocyte dysfunctions resulting in high spontaneous release of fas this chronic release and elevation of systemic fas is a major driver of systemic insulin resistance type 2 diabetes and other cardiometabolic diseasesi postulate that long noncoding rnas lncrnas interact with the metabolic machinery within the adipocyte to organize cell and stimulationspecific interactomes channelling substrate flux within the cell adipocytes express over 4000 lncrnas many of which are unique to humans and this cell type however whether these lncrnas contribute to the adipocytes specialised lipid metabolism in health and disease is not understood this proposed research aims to address this questioni have already developed key methodologies to study lncrnas in human adipocytes including a novel technique called troops that identifies specific lncrnainteracting proteins leveraging an extensive bank of white adipose tissue biopsies from uniquely characterized patients i will identify diseaseregulated lncrnas and test how they function in human adipocytes i will use gene editing techniques and lipidmetabolomics analysis to define the role of these lncrnas in lipid storage and fa releasefurthermore i will use proteinlncrna complex purification combined with advanced microscopy techniques to reveal how lncrnas can sequester protein complexes into phaseseparated organelles and organize adipocyte lipid metabolism these insights will provide a paradigm shift in understanding how lncrnas enable the adipocyte to perform specialized functions and new generalizable findings for how lncrnas contribute to cell function
residue management in the olive oil industry valorisation and environmental protection

the main objective of remoove is to study existing and novel opportunities for an integral valorisation of alperujo a residue from the extraction of olive oil that creates significant environmental impacts the aim of the valorisation is to obtain compounds and materials of high interest and minimise the environmental impacts associated with alperujo management the following valorisation routes will be investigated use of clay and fresh alperujo to manufacture green roofs recovery of compounds of interest from the liquid fraction of degreased alperujo by thermal hydrolysis production of lowcost adsorbent materials from the solid fraction resulting from the hydrolysis process of degreased alperujo for the removal of contaminants from wastewater and production of fuel gas by gasification of the solid fraction obtained from thermal hydrolysis of the degreased alperujo once the valorisation processes are defined and have been tested in a laboratory scale a thorough environmental impact study will be carried out to ensure that the sustainability performance of the proposed alternative is superior than that of the current waste management strategy for this the lifecycle assessment methodology will be used to evaluate environmental impacts for all relevant impact categories from the moment alperujo is obtained until alperujo and all its byproducts are managed a socioeconomic assessment and resilience risk analysis will also be performed in the last stages of the project to ensure the solutions proposed are viable at an industrial scale it is expected to integrate the alperujo valorisation processes into the olive oil industry upgrading existing manufacturing plants to olive oil biorefineries and therefore supporting the circularity in this key sector in the economy of southern europe
ddgmri for cancer detection a novel medical imaging approach that correlates to fdgpet without ionising radiation

positron emission tomography pet measurements of 2deoxy218ffluorodglucose fdg uptake have been widely used clinically for tumour staging prognosis and treatment monitoring where it can be more sensitive at detecting treatment response than magnetic resonance imaging mri and computerised tomography ct based evaluations of tumour size 2deoxydglucose dg and fdg are nonmetabolisable derivatives of dglucose that get trapped in the cells of active or malignant tissues even though highly sensitive the ionising radiation associated with fdgpet limits its frequent application typically not more than 23 examinations per year and its use in populations such as children and pregnant women who may otherwise benefit from this valuable and unique diagnostic imaging examination as such alternative techniques are highly demanded the ddgmri project aims at providing the benefits of fdgpet without ionising radiation we propose an mribased imaging agent and technique that will provide petlike images with mri without ionising radiation to this end we will make use of 1 a novel dg analogue that is uniformly labelled with deuterons d82deoxydglucose and 2 rapid and sensitive deuterium mri schemes targeted at demonstrating the uptake of this agent in malignant tissues further to intravenous administration the expected spatial resolution will exceed that of fdgpet 23 mm in plane in a scan time of about 2 min with a clinically acceptable and commercially relevant dose of the labelled compound ddgmri is likely to be quickly adopted by medical centres as it does not require significant hardware changes does not change the mri suite workflow and is expected to cost the same as a pet scan this consortium comprises six partners two from industry from five countries enthusiastic about making ddgmri a medical reality for cancer detection and treatment monitoring
interoperable tools for networkaware ledgerbased local energy sharing and flexibility management leveraging user engagement

to reach netzero emissions by 2050 annual clean energy deployment needs to triple by 2030 two major challenges hinder progress grid operators lack the tools to manage distributed energy resources effectively and citizens are not equipped to effectively participate in energy markets particularly in peertopeer trading which would foster individual investment in ders while the eu has established a legal framework for energy communities its implementation has been restrictive leading to energy communities based on predetermined communitylevel prices and effectively peertomarket rather than true p2p trading the intelligent project will provide advanced p2p technology and demonstrate its benefits in 4 diverse eu communities to encourage regulators in eu member states to empower more advanced local energy sharing and trading intelligents comprehensive p2p trading infrastructure includes interoperable decentralised energy exchange components secure data exchange and optimised trading and flexibility management for citizens and grid operators these tools will be open source and protocol and regulationagnostic customisable for specific market requirementsthe project leverages and extends the capabilities of the gsy dex an opensource p2p exchange software which employs blockchain technology to enable gridaware secure and automated exchange while fully accounting for network constraints innovations centres on a bottomup assetbased energy market design with sophisticated aiml and blockchainpowered trading and flexibility mechanisms supported by dynamic grid fee models and interoperability with grid operators asset management and other related services intelligents goal is to advance p2p energy trading technology making it more accessible secure and efficient to optimise the economic and environmental benefits for citizens while supporting grid operators to better address grid stability and congestion management
exploring the mechanisms of longterm tumour evolution and genomic instability in marine transmissible cancers

cancers are proliferative outgrowths of abnormal cells driven by a selfish evolutionary programme most cancers arise from and remain within the bodies of their respective host individuals rarely however cancers may escape their hosts to become transmissible cancers infectious cell lineages that spread between individuals by direct transfer of cancer cells as parasitic cancers capable of surviving for millennia transmissible cancers offer a unique model for exploring how mutation selection and cellular processes mould and constrain selfish tumour evolutionmarine bivalves shellfish including clams mussels and cockles are affected by at least 10 transmissible cancers which spread via waterborne cell transfer the recurrent emergence of longlived cancers in shellfish provides a valuable resource for comparative studies aiming to probe the basic mechanisms of tumour evolution including extreme genomic instability yet the evolutionary histories of these cancers are poorly understoodmy vision is to elucidate the origins and evolution of marine transmissible cancers by conducting a largescale comparative genomic study of these cancers my aims are to1 understand how transmissible cancers arise mutate and spread under the sea2 identify the mechanisms and consequences of genomic instability in transmissible cancersmy research approach will involve extensive tumour sampling across continents generation of highquality bivalve genome assemblies application of stateoftheart technologies including laser microdissection and singlecell sequencing to hundreds of tumours development of specialised methods for comparative cancer genome analysisthe intrinsic heterogeneity and short lifespans of most cancers may obscure their underlying biological patterns by examining the convergent evolution of 10 longlived cancers through a comparativegenomics lens i intend to deliver fundamental insights into cancer biology and evolution