Dragon09/odtu_chatbot huggingface dataset:
boosting engagement to increase flexibility

the increased shares of renewable energy combined with the rise in distributed generation are profoundly impacting electricity markets and the demand for system flexibility and business models of traditional utilities and distribution companies this requires a rethinking of the way power sector markets are designed and operated as well as a timely and efficient adaptation of traditional market and operational mechanisms the recent created clean energy legislation requires that electricity markets are created with active customersconsumers and citizens and energy communities this new legislation asks for enhanced roles of dsos and tsos particularly for a better coordination among stakeholders procurement of ancillary services flexibility data management and integration of electric vehiclesand must adapt network access and congestion tariffs charges flexibility markets must encourage the development of more flexible generation and demand and the elimination of obstacles to marketbased pricing remove regulatory distortions enable scarcity pricing interconnection demand side response and storage final customers must be enabled to buy electricity generation from aggregated multiple powergenerating facilities or load from multiple demand response facilities to provide joint offers on the electricity market and be jointly operated in the electricity system citizens must be offered competitive prices beflexible aims at increasing energy system flexibility enhancing cooperation among dsos and tsos and easing participation of all energyrelated actors through the validation and largescale demonstration of adapted and proven crosssectoral services interoperable platforms for smart grids operation developing further already demonstrated solutions and the creation of required system architecture framework to enable the creation of new business models providing additional value to meet consumers needs in compliance with a stable regulatory framework
computational and experimental enzyme engineering for new polymers

polymeric materials are ubiquitous in our daily lives but they have a predominantly fossil origin with low degradability at their endoflife transitioning to a circular polymer economy requires a rethinking of the entire value chain from the raw materials tools and processes used to polymer design degradation and recycling enzymes are ecofriendly and sustainable tools that tackle many industrial applications however biocatalysis in the polymer field remains mostly unexplored due to i enzymes high cost and low stability under reaction conditions ii enzymes inefficiency in converting biobased monomers into costeffective building blocks and iii lack of knowledge in key enzymepolymer interactions that can control the final polymer performance and degradability features computational tools have shown immense power to revolutionize the field of enzyme engineering in a time and cost effective way however there is currently a clear lack of researchers combining computational and experimental skills capable of determining future directions for the optimization of biocatalytic processes for the sustainable molecular design of polymers to foster the transition to a biobased polymer industry comenze aims to develop enzymatic strategies for improving the ecodesign and development of future sustainable polymers this will be achieved by combining cuttingedge computational and experimental approaches for enzyme discovery and engineering through insilico modeling simulation and translation of results into wet labs to validate enzymatic reactions comenze will train the next generation of researchers by equipping 10 dcs with the skills to revolutionize the polymer circularity by delivering new optimized enzymes and bioprocesses newly identified biobased building blocks and functionalized polymers with innovative bioupcycling and biodegradation endoflife options
trustworthy intelligent system for remote digital tower

remote digital towers rdt are taking place around the world to ensure efficiency and safety trusty harnesses the power of artificial intelligence ai to enhance resilience capacity and efficiency in making significant advancements in the deployment of digital towers the overall goal of trusty is to provide adaptation in the level of transparency and explanation to enhance the trustworthiness of aipowered decisions in the context of rdt through the video transmission data from rdt trusty considers the following major tasks1taxiway monitoring ie bird hazard presence of a drone autonomous vehicle monitoring human intrusion etc2runway monitoring approach and landing misalignment warning and the corresponding explanationto deliver trustworthiness in an aipowered intelligent system several approaches are considered selfexplainable and selflearning system for critical decisionmakingtransparent ml models incorporating interpretability fairness and accountabilityinteractive data visualization and hmi dashboard for smart and efficient decision supportadaptive level of explanation regarding the users cognitive statehumancentric ai enhances the trustworthiness of aipowered systemshumanai teaming to consider users feedback to insure some computation flexibility and the users acceptabilityto achieve the goal trusty will rely on the sota developments in interactive data visualization and usercentric explanation and on recent technological improvements in accuracy robustness interpretability fairness and accountability we will apply information visualization techniques like visual analytics datadriven storytelling and immersive analytics in humanmachine interactions hmi thus this project is at the crossroad of trustworthy ai multimodel machine learning active learning and ux for human and ai model interaction
a personalized prevention roadmap for the future healthcare

prophet a personalized prevention roadmap for the future healthcare will develop a strategic research and innovation agenda sria for personalized prevention in order to support the implementation of innovative sustainable and effective personalized programmes to prevent common chronic diseases technological biomedical advances including omics data and digital tools make risk stratification at the individual level possible however development of personalized prevention approaches must be accompanied by healthcare system transition including citizen engagement healthcare professional education and addressing organisational social and legal issues prophet will be centred around stakeholder engagement and the sria cocreation process in relation to three main strands of activities mapping assessment and building firstly we will summarize evaluate and discuss with the relevant stakeholders the extent to which all these new technologies can synergise mapping secondly we will design a holistic framework the prophet framework that will include all the necessary aspects to appraise personalized prevention approaches and their adoption by public health authorities assessment thirdly we will support the introduction of personalised prevention programmes by providing guidelines for their design engaging with healthcare professionals especially those working with policy makers and increasing health literacy at the population level on the benefits of personalized prevention building prophet will liaise with other key current and forthcoming initiatives at eu level such as icpermed european partnership ep permed the csa beyond 1 million genomes b1mg and the ep on transforming health and care systems the consortium consists of 18 beneficiaries and 2 affiliated entities across 12 eu countries and a large number of stakeholders already engaged from different target groups
ecoevolutionary rescue of fragmented populations

here i will establish ecoevolutionary rescue analyses as a predictive science i will do this by developing theories principles and tools for assessing whether populations can cope with changes in the environment at both short ecological and long evolutionary timescales i contend that analyses involving the capacity of organisms to adapt to environmental changes must be based on theories including realistic ecological assumptions my aim is therefore to develop a common theoretical framework for analyses of ecoevolutionary dynamics that includes basic features that characterize almost all natural populations such as stochastic fluctuations in population size densitydependent feedback mechanisms and dispersal among geographically separate populations i will be able to achieve this ambitious goal because i have recently been involved in developing a new set of theories that have identified novel quantities based on general ecological characteristics that ecoevolutionary processes tend to maximize these provide objective measures of a populations capacity to change which can be used to assess the consequences of habitat loss and changes in environment variation such as those expected due to climate change i will be able to parameterize these models via my access to one of the largest individualbased longterm field studies of any vertebrate species including data of more than 36000 individual house sparrows from 18 populations on islands within a large geographical area of northern norway which will enable me to quantify processes rarely analysed before in natural populations a central focus will be to derive new metrics that describe how the degree of persistence of a population to environmental change depends upon its size and population dynamic characteristics thus this project will provide operationalization of ecoevolutionary rescue analyses as a research field for assessment of the vulnerability of species to global changes
the role of olfactory sensitivity on task specialization in a social insect

division of labor and task specialization are key elements explaining the remarkable ecological success of human and animal societies social insect colonies are characterized by a highly effective division of labor with workers specializing in brood care early in life and in foraging later in life various theoretical models have been proposed to explain division of labor most prominently the response threshold model which postulates that individuals differ in their response threshold to taskassociated stimuli and will engage in particular tasks depending on this threshold while this model has received some experimental support the current data still do not explain how division of labor is implemented for all different tasks of a social insect colony how is division of labor implemented the success of social insect colonies lies in the capacity of all its members to behave in a wellorganized manner which involves elaborate communication among colony members accordingly ants wasps and bees use a wide range of pheromones intraspecific chemosensory messages to regulate almost every aspect of their life astonishingly the role of olfaction the main sensory modality used by insects on the division of labor has been greatly overlooked using the honey bee apis mellifera as a model i propose and will investigate the groundbreaking hypothesis that variation in olfactory perception and processing especially regarding social pheromones can give rise to division of labor i will use a novel approach in social insects based on newly developed neurogenetic tools i will compare olfactory perception and processing in the hives different worker task groups nurses foragers etc and will experimentally manipulate the activity of neural circuits involved in pheromone information processing while following bees behavior and task allocation in the end olftask aims to definitively establish the role of olfactory perception on the division of labor
cell identity reprogramming via onecut factors

neuronal loss is at the core of cognitive and functional failures of both acute brain injuries and neurodegenerative diseases direct neuronal reprogramming of local glial cells is emerging as a promising approach for restorative brain therapy however in order to use direct gliatoneuron reprogramming for the treatment of neuronal loss we still need to address a number of challenges namely reliable and longterm conversion into the desired neuron subtype in this proposal we aim to generate specific neuronal subtypes using novel fate determinants in gliatoneuron reprogramming and to provide a detailed molecular analysis of the newly generated neurons over time our data indicate that onecut factors may represent excellent novel candidates for astrocyte reprogramming into neuronal fates to address this possibility in this proposal we will focus on the thalamocortical system which represents the main input to the neocortex and it is essential to cortical processing we hypothesize that the innovative combination of nuclei specific thalamic factors with onecut factors could reveal new avenues for the direct reprogramming of astrocytes into thalamic neurons of specific sensory modalities and may inform future strategies for brain repair here we have unique expertise and molecular tools at hand that will allow us to reprogram astrocytes into specific neuron types in vitro and in vivo moreover as our ultimate goal is to reprogram astrocytes to recover neuronal loss we will test whether astrocytes from a sensory deprived thalamus can be reprogrammed by using stateoftheart techniques such as 3d lightsheet microscopy calcium imaging and transcriptomic analysis we will determine the fidelity and functionality of the newly generated neurons this approach will offer us unparalleled advantages for the discovery of novel reprogramming combinations and address important questions about reliable and longterm conversion into the desired neuron type
pulsed laser light and nanoencapsulated ocular dyes for advanced therapies in the eye

ocular diseases affect the quality of life of millions of patients despite improvements in pharmacological treatments the arsenal of medications to treat severe ocular diseases today remains rather restricted to traditional drugs use of most modern biotherapeutics like proteins and nucleic acids could be a major step forward however current ways of administration such as eye drops and intravitreal injections are no longer sufficient to deliver these drugs to most targets in the eye therefore novel concepts allowing biotherapeutics to safely overcome ocular barriers are of high interest in ocular surgery pulsedlasers pls are used for tissue cutting though safety concerns remain dyelight hypothesizes that strategies which would allow the use of pls in the eye at much lower energy than today could considerably improve safety and pave the way for both novel ocular therapies and advanced surgical interventions dyelight will explore vital dyes as used by ocular surgeons to stain tissues as photosensitizers dyelight follows the recent observation that pl irradiation of ocular dyes can result in the formation of water vapor nanobubbles dyebased nanobubbles and thermophoretic transport dyebased thermophoresis interestingly these biophysical phenomena occur at a laser energy that is 1000 times less than a pl alone as compared to free dyes dyes encapsulated in nanocarriers are expected to penetrate less into the retina which might improve safety therefore focus in dyelight will be on nanoencapsulated ocular dyes dyelight will explore the potential of dyebased nanobubbles for delivery of nucleic acids in the corneal endothelium and for spatial selective vitreolysis in the eye finally dyelight will explore dyebased thermophoresis for controlled transport of nanomedicines injected in the vitreous towards the retina if successful this might open new perspectives to improve the efficacy of retinal drug and gene delivery
acceleration of market deployment

graphene has the potential to revolutionise the technology industry but because the graphene market has problems producing large volumes of high quality graphene that potential has not yet been realised we have found a new way to make graphene from biomass our patent pending process allows us to produce large volumes of a graphene with properties optimised for energy storage and other applications where the electrical properties of graphene is in focus we produce a graphene powder with flakes that are larger and thinner than most of the massproduced graphene found on the market today this means that our graphene has high conductivity and a large specific surface area the thinnes of our flakes also make them transparent we call our graphene green because it is made from a renewable raw material instead of graphite like most other graphene and because we use no toxic chemicals in our production processwe have invested a lot in our thechnology but we apply for this grant because we feel that it is time to focus again on the business side this grant would be used to update our business model perform an extensive market analysis including developing a pricing strategy and to do a ip strategy
prostate cancer diagnosis localisation and characterisation using ultrasound

prostate cancer pca is a type of cancer with the highest incidence 19 and second mortality rate 8 in western men in 2018 in europe 140000 male patients were newly diagnosed with pca and over 100000 patients have died from prostate cancer numbers are rising due to the ageing eu populationthe present medical diagnosis procedures are largely based on the execution of multibiopsy procedures on the patient each multibiopsy procedure is invasive painful for the patient and incurs significant risk 1020 of adverse health events such as sepsis 8 screening programs comparable to breast cancer screening for woman are not possible based on biopsyin recent years in a few eu countries an imagebased diagnosis method has been added to the pca diagnosis pathway magnetic resonance imaging mri a dedicated mri imaging protocol offers an additional diagnosis tool for detecting and characterising pca tumour growth however mri based pca diagnosis has drawbacks scarce patient access no public healthcare coverage in multiple eu countries and long waiting times of 35 days median increased national healthcare cost and dependent on availability of highly trained radiologist the gap between the need for image based diagnosis and the availability is rapidly widening pcavision is a novel pca imaging diagnostic method relying on modern ultrasound imaging equipment and advanced signal processing algorithms advantages are equipment costs 96 less and there is not need for a specialised radiologist the urologist performs the diagnosis hence pcavision makes broad scale access for patients possible improves pca healthcare and reduces national healthcare cost with pcavision the gap can be closed for the benefit of all eu patientsthe result of the transition project is to complete validate and certify the pcavision solution enabling rollout to 16 eu clinics for clinical longterm demonstration enabling future broad utilisation
highperformance satellite avionics powered by agile semiconductor design

spherical disrupts outdated space electronics initiating a satellite tech revolution it pioneers a shift from standardised commodity components to prioritise custom chip designs taking control of tech and supply chains for superior outcomes this innovative strategy targets satellite electronics reducing reliance on vulnerable microchips and other components while addressing critical functional gaps the agile semiconductor engine drives rapid chip design cycles empowering compact subsystems and maximising efficiency through generative design our flagship component the pcdu ensures amplified efficiency significantly reducing time and expenses per satellite missionthis breakthrough innovation is positioned at the forefront of the industry poised to disrupt the market and capture significant market share this innovation represents a gamechanger and the projected revenue of 30myr by 2030 from selling satellite avionics to satellite integrators
r recycled industrial heat

heat is responsible for 74 of energy consumption in industry 90 of this energy comes from fossil fuels making industry the leading contributing economic sector to global ghg emissions with the introduction of tariffs for co2 emissions as well as high energy prices ie gas is the dominant source of heat in the industrial sector but at the same time one of the most expensive and noncarbon neutral resources process heat is nowadays a major cost factor for many industries in addition there is a legal obligation under eu rules to implement improvements in energy efficiency and decarbonize eg eu green deal to that direction industrial heat recovery is a key factor in order to achieve fossil fuels independence to achieve the climate goals nevertheless there is a gap for renewable industrial heat for low medium temperatures 100c 200c ecop has developed the rotation heat pump rhp k7 700 kwth the first highefficient and environmentally friendly industrial heat pump hp providing a valid alternative to fossil fuels heat production thanks to its innovative rotation principle counterclockwise joule thermodynamic process generated by means of centrifuge our first of the kind selfdeveloped and internationally patented technology 68 active patents enables the heat recovery use of waste heat in various energy intensive sectors as well as district heating applications thus enabling companies to transform their operations in line with the eu energy directives rhp k7 specifically closes the gap for renewable industrial heat for temperature range up to 200c our unique design results in a number of benefits production of co2free sustainable industrial heat without dependence on fossil fuelsefficient use of waste heat high efficiency at every temperature levelcontribution to climate targets and decarbonization eco climate friendly working gassavings in energy costs
between domestication and ferality cattlehuman relationships in the making of postcolonial southamerican society

starting with columbus third trip to the caribbean iberian cattle accompanied humans in the colonization of the south american continent since then the cattle population has grown exponentially all over the region adapting to a variety of local ecologies being exported all over the world and leading to the cattle industrys spectacular historical trajectory and economic success nevertheless the increase in beef and diary cattle production brought along negative consequences such as deforestation climate change and social inequality although the influence of cattlehuman relationships on society has been an object of study since the beginnings of the anthropological discipline the study of their entanglement with colonial ideologies and of their influence on south american society is just starting to take shape in order to highlight cultural and historical trajectories and create a new framework of analysis cowdom will compare different forms of humancattle relationships by focusing on opposing relational configurations of the domestication process feral cattle on the one hand and the socalled racially improved cattle on the other in some of the south american countries with the most intensive cattle production argentina brazil colombia and paraguay what values and ideologies frictions and dilemmas and what new socioecological systems did cattles presence enable both at the center and at the margins of societyin order to answer these questions cowdom will rely on longterm ethnographic fieldwork in cattle fairs and in areas with feral and semiferal cattle the fieldwork will be carried out by interdisciplinary teams formed by zoologists and anthropologists the project will establish an innovative theoretical framework to analyse cattlehuman relationships in a postcolonial context and incorporate experimental research tools such as video making and the collaboration with a contemporary art museum in south america