Dragon09/odtu_chatbot huggingface dataset:
recycling of high quality crm resources from machining tools for reuse applications

recycling of high quality crm resources from machining tools for reuse applications resqtool will offer a sustainable and energy efficient solution for recycling and responsible supply of critical raw materials co w ta ti nb from eol products in hard metal industries of metalwood cutting construction and tool manufacturing by lowering the carbon footprint and energy consumption of zinc reclaim process and developing advanced hydro and solvometallurgical biochemical recycling based on agroindustrial wasteresqtool will explore the potentials of zinc reclaim and biochemical recycling processes in the complete value chain of hard metals to offer a responsible circular and sustainable supply of critical raw materials in europe together with a contribution to eu climate neutrality objectivesthe project will demonstrate within 4 years the capability of these two complementary processes to reuse and recover critical raw materials in all stages of the hard metals value chain ranging from collection logistics sorting and separation to cleaning refining and purification of materials demonstrating an approach towards zero waste manufacturing by means of energy and resource efficiency and by a validation using real parts from the hm industry the project will go beyond the stateoftheart in terms of maturity from trl 5 to 8 and hence contribute to the european green deal
vesicular mechanisms of carbon fixation in calcifying cells of marine animals

the process of biomineralization has profound impacts on the geology of our planet and is an integral part of the global carbon cycle by generating large amounts of caco3 bound in coral reefs chalk mountains and deep sea sediments mounting evidence demonstrate that many marine calcifiers generate biominerals by the intracellular formation of caco3 from seawater ca2 and metabolic co2 to date the underlying mechanisms that control the carbonate chemistry in calcifying vesicles are unknown which however will provide groundbreaking insights into a biological process that is capable of transforming a metabolic waste product co2 into a versatile construction material in the past 5 years my group has developed a unique methodological expertise to study the cellular physiology of calcifying systems building on this expertise carbocell will tackle the important but challenging task to identify and understand the mechanisms of vesicular calcification the sea urchin larva will serve as a powerful model organism that represents a prime example for the intracellular formation of caco3 and which allows us to employ specifically targeted molecular perturbations in combination with subcellular ion and ph recordings carbocell will take a stepwise strategy to systematically examine the mechanisms of vesicular calcification on the three main core subjects carbonate chemistry wp1 ionco2 transport mechanisms wp2 and vesicular volume regulation and trafficking wp3carbocell will provide a deep mechanistic understanding of the calcification process with strong implications for explaining and predicting responses of marine calcifiers to the global phenomenon of ocean acidification more importantly knowledge about the mechanisms that allow organisms to transform co2 into a construction material will pave the ground for novel biologyinspired solutions of co2 capture and utilization a basic science approach at the core of twentyfirst century concerns
ai powered data curation publishing virtual assistant

integrated highquality personal health data phd represents a potential wealth of knowledge for healthcare systems but there is no reliable conduit for this data to become interoperable aiready and reuseready at scale across institutions at national and eu level aidava will fill this gap by prototyping and testing an aipowered virtual assistant maximizing automation of data curation publishing of unstructured and structured heterogeneous data the assistant includes a backend with a library of aibased data curation tools and a frontend based on humanai interaction modules that will help users when automation is not possible while adapting to users preferences the interdisciplinary team of the consortium will develop and test two versions of this virtual assistant with hospitals and emerging personal data intermediaries around breast cancer patient registries and longitudinal health records for cardiovascular patients in three languages the team will work around four technology pillars 1 automation of quality enhancement and fairification of collected health data in compliance with eu data privacy 2 knowledge graphs with ontologybased standards as universal representation to increase interoperability and portability 3 deep learning for information extraction from narrative content and 4 aigenerated explanations during the process to increase users confidence by increasing automation of data quality enhancement aidava will decrease the workload of clinical data stewards by providing highquality data aidava will improve the effectiveness of clinical care and support clinical research in the longterm aidava has the potential to democratise participation in data curation publishing by citizenspatients leading to overall savings in health care costs through disease prevention early diagnosis personalized medicine and supporting delivery of the european health data space
drug solution for bone fracture nonunions

bone fracture nonunion fnu is one of the leading unmet orthopaedic clinical needs resulting in billions of healthcare costs annually without any drug approved by regulatory agencies for this debilitating indication due to considerable shortcomings of the current best practices in treating bone fnus patients are facing increased risks and morbidity the market has available only bone substitutes and enhancers with limited clinical efficiency highlighting an essential need for more effective therapies genera research is on its way to filling the gap with its globally patented osteogrowc product a novel biological drug transforming patients blood into bone the proposed osteoforunion project aims to develop and commercialize osteogrowc an innovative drug for bone regeneration osteogrowc is a novel treatment option for bone fnus an implant composed of an active substance recombinant human bone morphogenetic protein 6 rhbmp6 incorporated in an autologous blood coagulum abc where tricalcium phosphate tcp ceramics is added as a compression resistant matrix crm this combination forms a personalized implant that catalyzes bone growth at the implantation site it is easily prepared in the operating room from the patients blood without the need for a painful bone harvesting procedure as in current treatment practices with associated complications and morbidities donor site pain infection nerve injuries blood loss or iliac wing fracture etc and related additional healthcare costs osteogrowc targets the global fnu market which serves 6m patients yearly key overlapping markets are fracture fixation orthobiologics bone grafts and bmp osteogrowcs unique stance promises to revolutionize the fnu market the initial market entry will concentrate on the markets in the eu with 180000 diagnosed long bone fnus in europe annually simultaneously osteogrowc will be launched in the us addressing more than 120000 bone fnus
experimental search for quantum advantages in thermodynamics

the technology advances of the last decades are forcing us to rethink laws and concepts of thermodynamics an intense theoretical effort is underway to understand the role of quantum mechanical ingredients in thermodynamic processes this effort might ultimately lead to more powerful engines less energy waste fastercharging batteries however despite pioneering experimental work progress is hindered by the lack of a comprehensive experimental testbed for quantum thermal machinesin this project i aim to provide the most ambitious and systematic experimental search for quantum advantages in thermodynamics thus far based on a circuit quantum electrodynamics architecturei will first complement the toolkit of circuit quantum electrodynamics with a novel arrangement which i term the engineered physical bath this bath has a broadband ohmic spectral density it can be populated with any spectral distribution and coupled to quantum thermal machines with arbitrary strengths finally heat flows between the bath and the machine can be detected deep in the quantum regime and in a spectrally resolved way based on this augmented architecture i will implement three types of novel quantum refrigerators i devised each refrigerator to pinpoint the utilization of a specific quantum resource quantum coherence measurement backaction and collective effects i will measure the cooling power of the refrigerators while in situ exploring an unprecedently large space of parameters and connect my results to the most recent theoretical frameworksfrom this investigation i expect two kinds of scientific breakthroughs i observation of features that are unambiguously nonclassical in thermodynamic observables and ii determination of advantages enjoyed by quantum thermal machines when fairly compared to their classical counterparts broadly this project will deepen our understanding of quantum thermodynamics while establishing a new standard for experiments in the field
reorienting the foundations of new science john philoponus and the modern theories of space and void 15201604

jophil will provide the first systematic study into the origins of our modern conceptions of space and void as people living in the 21st century we give for granted that objects are tridimensional and that void space exists in nature or it can be produced artificially yet this was not always the case aristotle the great ancient thinker whose worldview remained dominant in europe well into the 17th century thought otherwise he understood objects as having two dimensions only and he resolutely rejected the idea that void space could possibly exist the first thinker to take exception to aristotles views was john philoponus a 6thcentury egyptian scholar writing in greek unknown in the middle ages philoponus works were rediscovered and translated only in 15thcentury italy once available they had a seismic impact on renaissance natural philosophy and science they provided renaissance scholars with the tools to rethink crucial aspects of the physics of the time and they laid the foundations of the new science which would emerge in the 17th century challenging the dominant eurocentric narratives about the origins of the scientific revolution jophil will map for the first time the rediscovery and progressive assimilation of philoponus innovative ideas of space and void into 16thcentury europe it will do so by examining the material recovery of philoponus texts in renaissance italy and by exploring their impact on five european thinkers who between 1520 and 1604 read and discussed philoponus works jophil contributes to reorient the origins of modern science in two different ways first it reevaluates the role played by noneuropean thinkers in the shaping of european science thus fostering a new idea of europe as the historical product of a variety of different cultures and traditions second it broadens the canon of the protagonists of modern science thus contributing to more inclusive research and educational practices in the future
friends with benefits the role of endophytic bacteria in legume nodules containing nitrogenfixing rhizobia

from shoot to root plants are exposed to a diverse range of microorganisms which can play a major role in plant health growth and development a small fraction of bacteria can cause disease the vast majority of bacteria has no known effect on the host but there are bacteria that are beneficial to the plant these microbes are able to protect plants from pathogens modulate immune responses or assist in nutrient uptake the best studied beneficial relationship for both plant and bacteria is the longterm biological interaction symbiosis between legumes and nitrogenfixing bacteria these bacteria called rhizobia are hosted in root nodules of legumes such as clover or alfalfa where they fix atmospheric nitrogen however rhizobia are not the sole occupants of nodules and despite early findings of the presence of other nodule associated bacteria nab the diversity and role of nab in symbiosis and plant growth has remained neglected legumes are important crop in agriculture worldwide and as such the potential of plant growth promoting bacteria and increase of nitrogenfixation abilities is a major topic of research aiming to enhance agricultural productivity investigating the genetic material of all the microbes the socalled microbiome of legume root nodules will allow investigation of genetic features of those bacteria which contribute to increased plant growth and nutrient availability here i will use a holistic sequencing approach to i unravel the diversity and metabolic properties of nab in legume nodules and ii gain insights into the environmental factors affecting nab community composition iii determine to what extent the bacterial community in the soil rhizosphere drives nodule community composition the proposed research will provide a better understanding of the biological role of all cooccurring bacteria in nodules in the otherwise binary interaction of legumerhizobia symbiosis
nanohelicoid metamaterials templated by cellulose nanocrystals with endtethered polymers

chirality plays a fundamental role in natural sciences and pharmacology the ability to detect chiral molecules relies heavily on inherently weak circularly polarized lightmatter interactions such interactions are enhanced in the presence of chiral metamaterials which exhibit extraordinary electromagnetic properties not observed in nature to date large and broadband circular dichroism in the uvvisible spectrum requires arrays of metallic nanohelices in order to combine internal and bragg resonances however their fabrication relies on costly electronion beam lithography or physical vapor deposition in which it is difficult and timeconsuming to control nanoscale morphology over large areas new types of helix metamaterials and engineering processes based on selfassembly concepts are absolutely necessary in order to be viable for future technologies nevertheless selfassembled metamaterials with large broadband and tunable chiroptical responses in the uvvisible region is a great challenge due to the required subwavelength feature sizes to this end the helicoidal morphologies of chiral liquid crystals provide the ideal platform for maximizing chiral lightmatter interactions the objective of celicoids is to investigate the use of the chiral liquid crystal phases of cellulose nanocrystals with endtethered polyoxyethylene analogues as templates for the fabrication of a new class of metamaterial solid metallic nanohelicoids a recent breakthrough that now makes this project possible is the discovery that such cellulose nanocrystal hybrids form chiral liquid crystal phases as one of the very few researchers in the world with the combined expertise in cellulose chemistry polymer grafting and colloidal assembly i am the ideal candidate to achieve success new functionalities are envisioned thereafter applicable to future devices for invisibility cloaking superresolution imaging and chiral sensing prompting a change in paradigm in metamaterials
developing scientific research with ethics and integrity

different machines of trust in science have been identified in the literature research ethics research integrity science communication benefit sharing and technology assessment previous eu funded projects have focused on particular actors of the trust in science ecosystem eg scientists research funding organisations research ethics committees to explore the impact of particular machines eg science communication research ethics verity goes beyond the state of the art by conceptualising stewards of trust as the actors of the ecosystem that are responsible for upholding societal trust in science and facilitating sciencesociety cocreation either this refers to formally responsible organisations like research funding organisations and higher education institutions or it refers to de facto responsible organisations like social media companies and video streaming platforms which influence societal perceptions of science and innovation verity combines multidisciplinary expertise both from the social sciences and engineering to synthesise existing knowledge to evaluate tools and methods for enhancing trust in science through original research and smallscale participatory activities before producing the verity protocol of recommendations for stewards of trust verity brings forward interdisciplinary expertise to perform network analysis and execute interventions on social media to validate the verity protocol and alleviate practical barriers for its uptake in practice by different stakeholders verity findings will be widely disseminated to different stewards of trust such as policymakers research funding and performing organisations higher education institutions and other research and innovation actors to enhance societal trust in science and facilitate sciencesociety cocreation
a bone marrow mimicry bioreactor for cost effective production of hematopoietic stem cells

hematopoietic stemprogenitor cell hspc therapies have the potential to treat over 70 diseases including blood cancers and leukemia and are one of only 22 advanced therapy medicinal products currently approved by the european medicines agency however the number of hspcs derived from a single blood donation can be insufficient for modern therapies which typically require a minimum of 107 cells to service adequate treatment regimes hspcs must be expanded in the laboratory at great financial expense resulting in exorbitant treatment costs of up to 315000 new methods of ex vivo hspc expansion are therefore required to reduce production costs and ensure therapy affordabilitythe industry standard for hspc expansion utilises liquid suspension bioreactors where cells are diluted in litres of culture media to a final concentration of only 1035 cellsml this liquid media containing large amounts of expensive nutrients provides high cell expansion but results in high production costs liquid suspension bioreactors vary significantly from how humans grow hspcs within highcelldensity tissue 10811 cellsml which require only a fraction of the nutrient quantities percellthe bone marrow is the human bodys natural hspc bioreactor and provides a defined microenvironment for optimal cell production i aim to artificially replicate these niche conditions by creating a marrow mimicry bioreactor marrowmimi to maximise ex vivo hspc expansion by 1 formulating a hydrogel scaffold to mimic the bone marrow extracellular matrix 2 utilising stateoftheart 3d printing technologies to create a marrowlike perfusion bioreactor and 3 optimising reaction conditions to maximise hspc expansion and minimise nutrient demand the ability to minimise hspc expansionassociated costs could ensure lifesaving therapies are more widely available to the community therefore marrowmimi will focus on optimising methods for cost effective ex vivo hspc production
impact of climate change on twilight zone fishes during earlystage development

twilight zone tlz hosts the largest and least exploited fish stocks of the worlds oceans these fishes play a key role in ecosystem services such as sustaining other relevant marine species and global carbon cycle the tlz research is still in its infancy but the high biomass has raised interest in its exploitation mainly as fish meal but also as nutrapharmaceutical compounds moreover climate change is altering the environmental conditions in ways of which we do not know how life in tlz will be affected it is alarming that this vast ocean domain is at risk even before any of the potential consequences of fishing are fully understood one of the most threaten and less studied aspects of the tlz is the early life stage of its fishes please project aims to fill this gap of knowledge the first objective is to set background information about basic biology of the embryonic and larval development of different tlz fishes it will be achieved by establishing a suitable methodology for assisted reproductive technology in laboratory conditions since the wild tlz fishes are vulnerable to captivity the reproductive methodology will be transferred to the nonacademic partner for developing pioneered aquarium exhibitions the second objective is to examine the developmental responses of the embryos and larvae due to ocean warming and acidification under climate change scenarios it will be monitored via the developmental variability metabolism physiology morphometry and mortality rates of the specimens the outcomes of the project will be of paramount importance to forecast the impact of climate change on the community of tlz fishes and will open a new era for more investigation in this pristine and vulnerable zone of the planet finally a range of interactions with stakeholders and public will ensure the project exploitation and improve the decisionmaking capacity of the policymakers related with climate change and fishing activities in the tlz
comprehensive strategies to tackle malignant tumors from nanomedicine and theranostics to precision medicine

strikedn will raise excellence in research and training in nanomedicineprecision medicine creating new generation of entrepreneurial and innovative multidisciplinary doctoral candidates new experimental aspects on design and synthesis of nanostructured magnetic materials will be applied to the development of innovative magnetic fieldresponsive nanotherapeutics for osteosarcoma os combinational therapy moreover the peculiar features of strike nanomaterials will be exploited for liquid biopsy using biological samples of brca breast cancer bc patients the cooperation among outstanding universities research institutes and industries will provide the dcs with transnational exchanges and the most innovative research trainings in novel anticancer therapeutic strategies including in vivo biological evaluation imaging in os and early diagnosis in bc strike will provide enhanced career perspectives in academic and nonacademic sectors for 8 dcs in highly innovative fields by interdisciplinary mobility among 12 institutescompanies in 8 eu countries strike aims to 1 develop 8 highly skilled employable doctoral candidates 2 enhance interdisciplinary capacity and cooperation within the eu nanomedicine and precision medicine research networks 3 strengthen eus competitiveness and growth in nanomedicine and precision medicine through the translation of the consortium researchinnovation outputs the consortium will fulfill its goals through a achieving research excellence b providing a complete cutting edge research and innovation training program with some of the european top research institutes and industry partners c hosting interdisciplinary and commercial workshops seminars and outreach events d maximizing knowledge transfer using open science and patents e delivering highly trained professionals whose profiles fit within the requirements of academia industry and publicprivate institutions fostering their employability and promoting the innovation of eu research