Dragon09/odtu_chatbot huggingface dataset:
biological nitrification inhibition bni of the root exudates under drought stress in wheat and maize

globally the use of nitrogen n fertilizer for agricultural purposes is tremendous with an estimated total of 120 million tyear due to high nitrification activity in the soil much of the n applied to farmland about 70 is not absorbed by the crops and gets washed out resulting in water pollution and the emission of nitrous oxide n2o a powerful greenhouse gas 298 times co2 global warming effect suppressing the nitrification rate of agricultural soil could be a sustainable solution plant roots can exudate natural compounds that prevent nitrification a process known as biological nitrification inhibition bni wheat and maize are staple cereals that require excess fertilizers and their efficiency has not increased to meet future food demand since 1980 the main aim of this study is to screen root exudates secondary metabolites of diverse wheat and maize genotypes for their bni compounds and also evaluate the bni potential under drought stress even though wheat and maize are major cereals covering the largest area among food crops the study of its root exudates and the potential presence of bni compounds and related bni capacity have scarcely been studied consequently the discovery possibility of new bni compounds remains minimally explored in these crops and root exudate plasticity in response to environmental changes is still extremely limited the evaluation and selection of crop varieties lowers the nitrogen fertilizer dependency and is suitability for sustainable agriculture translates into specific key activities 1 biochemical characterization of agronomic and environmental traits of the germplasm collection 2 measurement of secondary metabolites in root exudates of germplasm lines in glasshouse under drought stress conditions to explore the full diversity of natural metabolic variation and bni activity and 3 potential isolation of new bni compounds and understand how plant traits and phylogeny are associated to this capacity
microfluidic wastewater treatment and creation of green hydrogen via electrochemical reactions

macghyver produces green hydrogen from wastewater using innovation in highvolume microfluidics noncrm electrodes and electrochemical compression the device performs advanced water treatment while producing hydrogen resulting in clean water as a byproduct the design consists of modular stackable units capable of small to large scale production volume the novel components microfluidic electrolyser electrochemical compressor separator are combined with existing renewable energy sources for maximum sustainability design and development are guided by lifecycle analysis of each system ultimately the device enables the production of clean energy and clean water a key enabling technology for decarbonization and the advent of the european green deal
wireless ultrasound powered diamond based neural stimulators

the neurodegenerative diseases and neurological disordered in central nervous system cns are increasingly recognised as major causes of death and disability in the world which eventually treatment cost is about 800 billion per year the main reason behind the nonexistence of efficient treatment is that unlike young neurons mature neurons from the cns lose the ability to regenerate their axons after injury to understand the detailed mechanisms remain not only unknown in neuroscience but represents also a major challenge for public health and society neurostimulation is technique that stimulate the activity of neuron and provides solutions to fill the knowledge gap current neurostimulation techniques somehow limited to large neuron brain areas rely on wires to powering system and suffers from rejection by body inflammable the emerging wireless and batteryfree technologies based on ultrasonic communication allows to remove electrode connections to external source the overall goal of sononeuros project is to develop proof of concept of a fully wireless ultrasoundbased powering of electrical stimulation technique with in submm range with diamond electrode materials this research proposal aims to develop and validate the proposed stimulators for sufficient amount fully wireless power communication battery free with shrinking size for implantable within 100 m we will use diamond due to interesting properties for chronic implantation is its high resistance to corrosion very good biocompatibility in this idea combining ultrasound powering with piezoelectric micromachined ultrasonic transducer pmut technology to diamond electrodes in order to reduce the size results at a smaller scale axial resolution of single neuron activity after develop wireless neural stimulators we will have used it to study the effect of electrical stimulation on output of retinal ganglion cells rgcs which provides new way towards to visual prostheses
injectable nanoelectrodes for wireless and minimally invasive neural stimulation

neural devices used in the brain and spinal cord have yielded medical breakthroughs to improve the lives of people with spinal cord injury parkinsons disease and hearing loss however current neural devices are large complex and invasive and are therefore used by only a fraction of people who could benefit from them instead i want to make neural devices that are nanoscale injectable and wireless by lowering invasiveness and implantation risk this technology could address the unmet medical needs of more people with neurological impairments the work proposed herein is to develop a minimally invasive nanoelectrode system capable of wireless spatially selective and multiplexed neural stimulation i have previously developed nanoelectrodes that directly stimulated ie with no geneticbiochemical neuron modification the deep brain of mice as a proofofconcept this was possible because unlike other wireless neural technologies device powering was nonresonant and thus independent of size in my proposed research i will now develop optimized nanoelectrodes and i will approach this by developing a toolbox of nanomaterials to study and learn from in particular i will look at how nanoelectrode size and shape affects signalresponse and neurostimulation this approach will generate new enabling technologies such as the ability to individually stimulate some particles while ignoring others for multiplexed stimulation control while the field of nanoscale and wireless neuroelectrodes is exceptionally small new and high risk the proposed work could one day enable minimally invasive wireless neural modulation
the ethics of empty beliefs chinese buddhist philosophy in the period of disunity

is it ethical to believe chinbuddhphil will explore this basic yet troubling question by reconstructing what is a hitherto largely unstudied yet highly original philosophical conception of how belief relates to ethical action substantively this project will constitute a major contribution to the historical and systematic study of chinese buddhist philosophy it will accomplish this end through specialist research on the unduly neglected sanlun school a foundationally important movement active during a seminal period in the epochally transformative history of buddhism in china this will be the first comprehensive elaboration of sanlun philosophy in any western language by placing sanlun into debate with its indian antecedents later elaborations within chinese buddhism and analogues in western philosophy this project will also forge multiple disciplinary innovations thus within philosophy it will transform our understanding of philosophically valuable traditions by demonstrating that chinese buddhist philosophers merit consideration not only as historical artifacts but as genuinely interesting and insightful contributors to live philosophical problems it will likewise redress the preponderant exclusion of chinese perspectives from philosophicallyoriented scholarship in buddhist studies and do so in a manner that bridges it with philologicallyoriented buddhology and by investigating both the transmission of indian buddhist thought into china and its transformation once established there it will revise the standard chronology of chinese buddhist philosophy theorize indiachina as a globalized sphere of dynamic intellectual interaction within transcultural asian studies and inform scholarship on cultural appropriation and assimilation enculturation and acculturation all from a distinctly noneurocentric perspective methodologically chinbuddhphil will use synchronic hermeneuticphilosophical as well as diachronic texthistorical methods
disrupting gendered stereotypes and disclosing neglected valueladen motivations of academic entrepreneurship

economic growth boosted by entrepreneurs and gender inclusivity is one of the major priorities of the european agenda which calls for more entrepreneurs and empowers female entrepreneurship the transfer of knowledge and technology generated in academic settings to the industry is essential for this growth one condition for this transfer to happen is that researchers are willing to engage in research commercialization ventures or in relationships with industry actors previous research has shown on the one hand that scientists have intrinsic valueladen motivations to engage in these ventures or relationships other than pecuniary reasons
taxonomy and azole resistance in aspergillus section flavi

the project on taxonomy and azole resistance in aspergillus section flavi aims to investigate the classification and drug resistance patterns of fungal species within this specific section aspergillus section flavi comprises various species known to produce carcinogenic aflatoxins posing significant risks to human and animal healththe project involves taxonomic studies to accurately identify and classify different species within aspergillus section flavi this classification is essential for understanding the diversity and distribution of these fungi as well as their specific traits and potential virulence factors another crucial aspect of the project is the investigation of azole resistance in aspergillus section flavi azoles are commonly used antifungal drugs for treating aspergillus infections however reports of azole resistance in certain aspergillus species have raised concerns understanding the mechanisms behind azole resistance is crucial for developing effective treatment strategies and identifying potential targets for drug developmentthe project involves molecular analysis techniques to detect and characterize genetic mutations or other mechanisms associated with azole resistance in aspergillus section flavi additionally it may involve assessing the clinical impact of azole resistance on patient outcomes and exploring potential risk factors for the development and spread of resistant strainsby combining taxonomic studies with investigations into azole resistance the project aims to enhance our understanding of the diversity distribution and drug resistance profiles of aspergillus species within section flavi this knowledge can ultimately contribute to improved diagnostic methods treatment approaches and public health strategies to mitigate the impact of these fungal infections
science and dogma tracing natural knowledge within scholastic theology 15451789

the early modern period is usually viewed as a time of profound change including the socalled scientific revolution and the protestantcatholic reformation historians have linked these two seemingly disparate transformations in many different ways but one important dimension is yet to be uncovered scigmas main hypothesis is that natural knowledge significantly influenced dogmatics as a central branch of theology in the early modern university university textbooks eagerly addressed many questions related to natural knowledge such as can the bodily resurrection be understood from a physiological perspective which physics apply for the eucharist while much has been written on the impact of theology on the natural sciences scigma will turn the tables to uncover their truly entangled relationship the project will systematically investigate how naturalism and empiricism informed scholastic and dogmatic theology from the council of trent to the french revolution across all western christian denominations its research agenda will consider theology as a scientia in the premodern university and therefore include it within the history of science and knowledgescigmas first goal is to discover the multiple and changing ways in which natural knowledge informed premodern scholastic theology which sought a rational reconstruction of faith second it will uncover what effective epistemological frameworks accommodated this interplay of empiricism and revelation third it will trace how these epistemological frameworks were determined by their embedding within religious and secular institutions of learning this complex historical analysis will reveal the significant role of the physicodogmatic domain in institutional learning thereby it sheds novel light on how premodern western societies fundamentally reshaped scientific inquiry while being deeply religious and ultimately paved the way to secularization and scientism in these societies
water for the people dcor for the city nymphaea and public fountains in iudaeasyriapalaestina and provincia arabia from the roman until the byzantine periods ca 1st bce7th ce

hydraulic installations play a fundamental role in human survival development and the prosperity of urban settlements mostly in semiarid regions in this regard waterdecor plans to investigate nymphaea and public fountains in iudaeasyriapalaestina and provincia arabia from the establishment of the roman province until the byzantine period ca 1st bce7th century ce it analyses the ways in which these water management installations were built across this vast semiarid geographical area and evaluates cultural social and economic implications through a historical perspective and the record of past societies this project embraces the eus challenges in the field of climate action and resource efficiency bringing awareness to the importance of conscious water use furthermore in line with the strategic framework for the eus cultural policy and the european neighbourhood policy enp this research promotes international cultural relations with southern neighbours israel syria jordan palestine lebanon the projects novelty consists in considering a group of infrastructures from a vast geographic area over time and most importantly it undertakes an overall examination that moves away from traditional studies based on individual monuments or typology stricto sensu it delves into a multitude of aspects that makes it possible to enhance several issues spanning from ancient technologies to climate change issues the specific objective focuses on nymphaea and public fountains in a context of semiarid o arid climatic conditions which makes the construction of large waterconsuming structures challenging the second objective investigates urban and sociocultural contexts and how these constructions were perceived by the local population the third objective examines climate change effects on these structures and in general on the urban water distribution system
additive manufacturing of amorphous metals for soft magnetics

am2softmag is working toward the vision that one day 3d printing will become the de facto standard technology for the manufacturing of highperformance amorphous softmagnetic components for highly efficient electrical machines and passive electrical components to prove the viability of the approach the partners expect to demonstrate superior operating efficiency of an electric motor comprised of softmagnetic stator and rotor components created by means of selective laser melting slm of softmagnetic bulk metallic glass bmg alloys and powders specially designed and optimized for the additive manufacturing am process adding to the already outstanding magnetic and mechanical properties of bmgs this incremental casting process overcomes the wall thickness limitations of conventional metallic glass casting processes enables the energyefficient near netshape production of complex geometries not achievable by other means and opens up avenues for the digital design of microlocalized properties throughout the components furthermore the method will expand the spectrum of manufacturable and recyclable amorphous metals thereby increasing the availability of alloys with unique magnetic and mechanical properties while reducing or eliminating the need for environmentally critical elements such as cobaltwe establish a long overdue cooperation among academic and industrial leaders in the fields of metallic glass design and processing mechanical and magnetic testing quality control and certification as well as design and testing of electrical machines through the design of powdered amorphous softmagnetic alloys optimization of slm process parameters and verification of resulting electromagnetic devices we will achieve major breakthroughs in the flexible and energyefficient production of superior softmagnetic components thereby enhancing the energy efficiency of electrical devices and thus substantially contributing to the european green deal
ice coupling protein inhibitors

antibiotic resistance ar is one of the greatest threats to human health the global overuse of antibiotics has resulted in the proliferation and dissemination of antibiotic resistant bacteria harboring a multitude of antibiotic resistance genes that can be mobilized by different horizontal gene transfer processes such as conjugation integrative conjugative elements ices are mobile genetic elements which are typically found integrated in the bacterial chromosome and encode the machinery for their conjugation the socalled coupling proteins have a critical role in the conjugation process icecoup is focused on the molecular and functional characterization of a critical component for ice transmission the coupling protein with the ultimate goal of finding ice conjugation inhibitors to block or at least minimize the ar spread to date ice coupling proteins have received little attention despite their importance in the transfer mechanism the supervision of dr itziar alkorta at the university of basque countryupvehu is a key element to guarantee the success of this project icecoup will generate extensive and innovative scientific outputs that in the long run will have a societal impact enhancing the catalogue of weapons to combat antibiotic resistance the multidisciplinary approach of icecoup will allow me the reinforce my scientific knowledge and soft skills while i acquire outreach and project management capacities undoubtedly should this project be funded it will strengthen my prospects to forge a stable career as an independent researcher able to secure funding
hormonefree solution for vaginal atrophy

vaginal atrophy va is a chronic and progressive condition va impacts on the quality of life relationships everyday activities and confidence of women sufferers it is associated with thinning drying and inflammation of the vaginal tissue it is experienced by 80 of all women globally and is the most common symptom of the menopause over 70 of breast cancer survivors will also suffer from va due to side effects of chemotherapy and the cancerblocker drugs they take further exacerbate symptoms of va current treatment options for va primarily pharmaceuticals are either ineffective or poorly tolerated in the eu and us 36m patients of va reject existing treatments aveta a medical device delivering the only hormone free affordable and safe targeted therapy for all women suffering from va solution is based on pathophysiology of wound healing and will be prescribed by a clinician in an outpatient setting and women will selfadminister the therapy monthly at home
deep multiplexed epigenetic profiling of plasma cellfree nucleosomes for early cancer diagnostics

over recent years cancer diagnostics based on cellfree dna cfdna in liquid biopsies demonstrated great promise in guiding treatment and screening for recurrent diseases current diagnostic strategies are mainly based on the analyses of dna mutations fragment length or dna methylation status however these strategies do not provide a universal approach for cancer identification are costly and labour intensive and generally fall short in detecting cancer at early tumorigenic stages or minimal residual disease an underexplored field is the development of diagnostic applications based on histone posttranslational modifications ptms the strategy to harness these epigenetic signatures to identify celloforigin is potentially superior over stateofthe art methods because it offers targeted and multiplexed amplifications of exclusively informative genomic regions ie promoters and enhancers such strategies are costeffective and display much increased sensitivity over existing methods in their accuracy in eg early cancer diagnoses relapse detection or screenings unfortunately the development of this field is hampered by a lack of methods that are sensitive enough to detect multilayered histone ptmsignatures in samples with limited material such as blood plasma this proposal describes our plan to implement two new strategies for ultrasensitive detection of multilayered histone ptms signatures in blood plasma our proposal outlines 1 a research plan for the implementation and optimization of these strategies to profile histone ptm profiles in plasma of healthy and patient material to determine the diagnostic potential of the method and 2 develop a market strategy and navigate product development opportunities for commercialization of the method successful execution of this proposal will result in the establishment of a novel diagnostic strategy with unprecedented potential for universal cancer screeningapproaches based on liquid biopsies
mcaa new horizon enhancing the impact of msca alumni on the european research landscape

the mcaanewhorizon project will provide support to the management of the marie curie alumni association mcaa as well as to the implementation of its core activities the mcaa is an international nonprofit organisation that brings together current and past marie skodowskacurie actions msca fellows its main goal is to increase the impact of the msca by promoting networking opportunities for the alumni by supporting their career development and by providing feedback to the european commission and other organisations on the msca and other policiesthe project activities will be organised in five core work packages governance management it includes activities aiming to ensure a proper management of the association eg support to governing bodies working groups and regional chapters wgc and the overall administration of the mcaa alumni engagement networking and services it includes activities aiming to engage msca fellows in the mcaa and its initiatives such as the annual conference and events organised by wgc it also aims to provide support for the career development of the msca alumni via access to education and training opportunities financial support for the participation in events and courses promotion of networking opportunities etc policy institutional relations it mostly concerns the provision of feedback to the commission on the msca and other policies partly based on surveys to the mcaa members it also includes all institutional relations with relevant scientific and nonscientific organisations that could represent a benefit for the msca alumni eg through partnership agreement with institutions communication outreach it includes all activities aiming to disseminate the activities of the association engage msca fellows and promote the msca to different audiences worldwide it infrastructure it will mostly deal with the further development of the website as a digital ecosystem