Dragon09/odtu_chatbot huggingface dataset:
central european advanced therapy and immunotherapy centre

progress in biomedical science enables scientists to use a whole new toolbox to treat significant groups of diseases such as inherited rare diseases or diverse rare cancers advanced therapy medicinal products atmps apply recent advances in genomics cell biology andor gene editing to deliver truly personalized curative options the project proposes to establish flagship atmpfocused facility on the margin of academia and clinics central european advanced therapy and immunotherapy centre creatic at the masaryk university mu in brno czech republic mu will team up with the leading european research institutions 1 fraunhofer institute for cell therapy and immunology izi 2 leipzig university which together forms a significant cluster of research excellence in research development and training in the fields of gene and cell therapies and 3 copenhagen university with unique expertise in biomedical innovation law intellectual property biomedical ethics privacy and regulatory framework and health technology assessment combining stm and ssh disciplines the project will allow for i fundamental expansion of the scope of the ri activities of all partners to build multidisciplinary excellence facilitating the delivery of atmps to patients who need them ii establishment of the high level of decisionmaking autonomy for the creatic which will allow significant organizational and management changes creating spirit and conditions for cuttingedge research and innovation in the centre and iii strengthen the smart specialization of the czech republic ris3 cz 20212027 in the domain of advanced medicine and drugs through the involvement of actors from the academic public private and societal sector our approach reflects research priorities and societal challenges outlined in the pharmaceutical strategy for europe which proposes bedside manufacture of highly individualised medicines as a future trend in treating rare diseases with atmps
postbiotic restoration of the metabolome of moms

microbial dysbiosis can lead to behavioral changes including aggressive behavior mice treated with antibiotics exhibit increased aggression as do offspring of mothers given antibiotics only during pregnancy or alternatively only when nursing promising results from our lab in flies and mice support our hypothesis that such behaviors are partially affected by gut bacteria and associated metabolic compounds pregnancy is associated with reduced immune function and women receive antibiotics during this period for a myriad of reasons preclinical trials and clinical research suggest strong effects of these treatments on offspring a postbiotic to be taken daily in a manner similar to prenatal vitamins following antibiotic use during pregnancy and breastfeeding can restore microbiota form and function towards alleviating changes in offspring behavior throughout our ercfunded research behaviome our approach to exploring the innovation potential of our research is a stepwise process a direct result of this process was the identification of the erc proof of concept as a viable route to defining the early commercialisation steps and obtaining internal support to develop and implement the project within promom we aim to complete two critical objectives significant progress on technology development poc demonstration in vivo pilot data and achieving business readiness market research business plan enduser engagement the outcome of the erc poc will enable us to take the last step precommercialisation developing market readiness for commercialization our plan is to set up a spinoff company that will develop several postbiotic leads either through funding raised through venture capital or codevelopment with other larger companies in the field with promom we will develop a postantibiotic supplement that promotes maternalneonatal microbiota restructuring and reduces behavioral disturbances in the critical first 1000 days of life
biogeography and resilience of intertidal southern ocean communities

the intertidal zone seashore is a critical environment at the interface of marine and terrestrial habitats where interlinked environmental and anthropogenic stressors occur in polar regions especially in the southern ocean biological communities living in the intertidal zone remain largely underexplored understanding the diversity and biogeographic relationships existing among intertidal communities would prove central for deciphering their origin and evolution it is also crucial to assess their vulnerability to global changes as the southern ocean is currently facing fast pace environmental changes biorisc aims to evaluate the biodiversity biogeography and resilience of intertidal communities at an unprecedented spatial scale across the antarctic and the subantarctic by using an integrative communitybased approach the project will address fundamental ecological questions involving the assessment of biogeographic regions the importance of environmental heterogeneities and the evaluation of community resilience to climate change scenarios the work will combine standardized in situ protocol with thorough taxonomic identification and genetic methods dna barcoding and metabarcoding of several genes to produce an unprecedented dataset for community structure analyses in addition biorisc has a strong conservation component including the monitoring of nonnative species the results will fit the needs of nature managers at both the regional crozet falkland kerguelen islands and global scales convention for the conservation of antarctic marine living resources ccamlr altogether biorisc will therefore provide a critical assessment of the uniqueness of these communities and test how their composition and distribution are likely to shift in the future based on ipccderived scenarios of climate change
protect and promote crop wild relatives

crop wild relatives cwr are wild plant species genetically related to cultivated crops their untapped diversity can enhance resilience to biotic and abiotic stress and the nutritional quality of modern crops wheat sugar beet and oilseed rape were selected by prowild because of their importance to food security and eu farmers and because some of their wild relatives are endemic to europe moreover these cwrs constitute a rich and underexploited resource needed to face challenges linked to climate change and the transition to lowinput agriculture the genetic diversity and vulnerability of these cwrs must be better characterized to optimize their conservation and utilization the objectives of prowild are to identify priorities for insitu conservation of the selected cwr gene pools to survey and complement cwr genebanks collections and to increase the use of cwrs in crop improvement prowild associates 18 partners from 11 eu and associated countries with expertise in ecology conservation genomics pathology microbiology plant breeding agriculture and sociology prowild will compile and analyse cwr occurrence maps and perform new insitu collections it will predict the vulnerability of several cwr species and populations to ongoing climate changes exsitu collections will be complemented with endangered cwrs accessions prowild will investigate the resilience of cwr collections for relevant biotic and abiotic stresses the identification of cwrderived desired traits and their transfer into elite backgrounds will be done to promote cwr use overall prowild specific goals will be coordinated with input from breeders farmers and consumers prowild outcomes will contribute to european green deal initiatives through research education and training it will serve the eu biodiversity and the farm to fork strategies by preserving characterizing and utilising wild species that have unique importance for the resilience of our food systems
digitalization of cultural heritage as discursive practice mapping the museums and citizensled initiatives in graz and novi sad

digitalization of cultural heritage as discursive practice mapping the museums and citizensled initiatives in graz and novi sad disculther examine how the process of digitalization of cultural heritage dch identified on a discursive level manifests in two kinds of settings institutional museums and activist citizensled initiatives the main objective of the project is to investigate the plurality of discursive practices of dch within mentioned settings the innovativeness discrepancies and tensions in these practices as well as the capacity of dch to make accessible mobilize and critically engage citizens in opening the space for intercultural dialogue it is a project with comparative dimension on two levels it compares the institutional with noninstitutional practices of dch but also the processes in two cities novi sad serbia and graz austria they share in part the common history culture and heritage in contemporary framework comparison aims to highlight social and cultural experience of the cities of which one belongs to the state member of european union and one is in the process of europeanization it is also interdisciplinary research that transcends the boundaries in social sciences between sociology heritage studies and digital humanities and foregrounds hitherto neglected aspects of the process of digitalization of cultural heritage
unveiling the role of histone marks in metabolic memory storage and transmission

type 2 diabetes t2d is a multifactorial disease affecting over 450 million people in europe alone amounting to the burden of lifethreatening diseases and worsening quality of life skeletal muscle is affected early in t2d and contributes to the fast decline of wholebody glucose homeostasis which is called insulin resistance interestingly even when isolated from the body and cultured in a laboratory in nondiabetogenic conditions the skeletal muscle cells do not lose the characteristics of the donor ie the cells remain insulin resistant indicating the existence of a cellautonomous mechanism that retains the metabolic memory across generations of cells nonetheless such a mechanism remains elusive accumulating evidence suggests a potential role of histone posttranslational modifications as essential vectors of inheritable information but it is still a matter of intense debate in this project to address this question and understand the pathology of t2d we will trace a comprehensive genomewide map of histone posttranslational modifications induced by t2d in human primary skeletal muscle cells and investigate whether these histone marks can store and transmit information about the metabolic phenotype from the donor to the next generation of cells targeted studies using pharmacological and genetic interventions will then address the role of histone modifying enzymes in metabolic memory transmission the outcomes could lead to a novel understanding of a broader system of cellular memory storage and transmission by characterizing the disturbances caused by diabetes in the epigenome using stateoftheart techniques and multidisciplinary approaches we could pave the way for innovative clinical interventions addressing a critical global health challenge
coming to terms proof theory extended to definite descriptions and other terms

the project is concerned with two areas which so far have rarely come together complex terms and proof theory extendd focuses on definite descriptions as the most important and troublesome singular terms and on sequent calculus and its generalizations as the most important tool of modern proof theory since russells on denoting regarded as a paradigm of analytic philosophy definite descriptions occupy a central place in philosophical research and many deep and detailed studies have been carried out the second half of the 20th century saw the development of new approaches to this phenomenon based on nonclassical logics in particular free logic in which contrary to freges and russells classical logic it is not assumed that every term refers yet despite the long history of research into definite descriptions a paradigm of formal logic has so far rarely been applied to them proof theory the methods developed by gentzen in particular those relating to his sequent calculus provide the means for the deepest study of proofs and their properties yet only a small effort has so far been put into the adequate treatment of definite descriptions in this framework the same counts for other complex singular terms such as set abstracts and number operators extendd fills this important gap in research applying the methods of proof theory to definite descriptions is profitable to both sides competing theories of definite descriptions and complex terms in general their advantages and shortcomings are shown in a new light the behaviour of complex terms needs subtle syntactical analysis and requires enriching the toolkit of proof theory extendd deals with both challenges it develops formal theories of definite descriptions and modifies the machinery of proof theory to cover new areas of application the realization of extendd affects significantly the field of proof theory automated deduction and philosophy of language
recyclable materials development at analytical research infrastructures

a radical shift to the circular economy is urgently needed to cope with the challenge of finite resources decreasing at a frightening pace while the quantity of waste increases alarmingly the european commissions ec circular economy action plan ceap adopted in march 2020 has identified seven key product value chains that must rapidly become circular given their environmental impacts and circularity potentials this requires substantial research on materials with a very high recycling capability while exhibiting competitive functionalities in remadeari the most significant european analytical research infrastructures join forces to pioneer a support hub for materials research facilitating a step change to the circular economy remadeari offers coordinated access to more than 50 european analytical research infrastructures comprising the majority of the facilities that constitute the analytical research infrastructures in europe arie network remadeari offers comprehensive services suiting any research focusing on the development of new materials for the circular economy in the key areas highlighted in the ceap and plays an important role in the preparation of the common technology roadmap for circular industries senior scientist facility experts and highly trained young researchers contribute scientific knowledge and extensive support to realise a user service of unprecedented quality making each promising idea a success particular attention is attributed to the implementation of attractive formats to support researchers and developers from industry the comprehensive service catalogue is complemented by an extensive training programme communication and dissemination activities are underpinned by a continuous impact assessment which also enables evidencebased decisionmaking in the context of the proposal selection routes to sustainability of the platform will be explored towards the end of the project
spectral geometry of higher categories

the overarching goal of this project is to reveal and systematically study the geometry of important categories in homotopy theory algebraic geometry and representation theory to this end we will introduce and develop the framework of higher zariski geometry in which commutative rings are replaced by ringlike categories as the fundamental objects the resulting theory simultaneously generalizes modern algebraic geometry derived algebraic geometry as studied by lurie and tonvezzosi as well as balmers tensor triangular geometry while introducing entirely new global objects and methods in particular it provides a canonical spectral decomposition of a large class of higher categories over their balmer spectrum which is then used to produce powerful new tools to tackle some of the most important conjectures in their respective fields firstly we will construct a higher analogue of the tale topology and tale homotopy types for such categories giving rise to refined computational tools via descent this machinery will be applied to modular representation theory to give a complete description of the group of endotrivial modules for any finite group and any field extending the celebrated work of carlsonthvenaz and completing a program that began about 50 years ago secondly we will introduce a categorical analogue of the beilinsonparshin adles in particular bringing to bear techniques from the pointset topology of spectral spaces applications include significant progress on greenlees conjecture on algebraic models for gequivariant cohomology for a general compact lie group g which has remained open for more than 20 years thirdly building on our earlier work on higher ultraproducts we will study compactifications of categories and plan to combine these with recent advances in arithmetic geometry to make progress on the rational part of hopkins chromatic splitting conjecture one of the most important open problems in homotopy theory
unruly entanglements of sociomaterial change knowledge and power in energy frontiers

energy is foundational to climate change adaptation and mitigation goals but the present moment requires more than clean power plants energy frontiers are entangled in uncertain geopolitics injustices environmental change and development efforts raising the stakes for research on sociomaterial change unruly aims to create a paradigmshifting new analytical framework of change one that transcends disciplinary conceptual boundaries to hold the social and the material together theoretically and methodologically grounded in justice issues the project has four objectives innovate a new theory of sociomaterial change through unruliness create new research methods to analyse sociomaterial change advance empirical research on energy frontiers and reframe what requires governing in unruly contexts unruly creates a novel theoretical basis for understanding how power materialises through uncertainties knowledges uneven social relations colonialism racism class patriarchy and governance challenges methodologically the project is carefully designed to build towards the higherrisk highgain dimensions the work will contribute fresh insights on hydropower energy frontiers in two case studies nepal and zambia and develop new methods capable of analysing variables and processes defined as inherently sociomaterial the results aim to tease out an analytical basis for democratic debate on the tension between efforts at prediction and governing change and uncertainty and unruliness which can derail those efforts the pi will lead an international crossdisciplinary research team comprised of two postdoctoral fellows two phd candidates three research affiliates and an advisory board of international academic leaders boldly challenging existing research conventions on sociomaterial change and reimagining novel approaches to our shared planetary crisis
precision drug repurposing for europe and the world

here we a group of longstanding collaborators in innovative drug repurposing propose to build repo4eu a comprehensive europeanglobal platform for validated precision drug repurposing open to stakeholders for information multimedia training matchmaking and cooperation drug repurposing reduces the time and costs of drug development but is often serendipitous and less effective than classical drug discovery both discovery and repurposing suffer from the same knowledge gap that diseases are mechanistically not understood and treated symptomatically in an imprecise manner our team of worldleading scientists overcome this by breakthroughs in advanced bioinformatics and artificial intelligence ai on realworld big data to redefine diseases in a mechanismbased manner patients are still identified by symptom but stratified according to causal mechanism the endotype trials are small precise innovatively designed prioritising in coordination with regulators payers and investors patientdefined outcomes with high safety and operational excellence this revolutionary new era of medicine will allow unprecedented efficacy and costeffectiveness the promiscuity of small molecules and recently expanded knowledge of protein structures are exploited by cheminformatics and deep learning to repurpose drugs beyond their original target at any level of the development chain even for classic projects repo4eu provides expertise and matchmaking for freedomtooperate intellectual property reformulation and valuecreation specialised in drug repurposing within 5 years repo4eu will establish a firstinclass coherent and innovative webbased platform for safe and efficient drug repurposing for all types of high unmet medical need indications to all european researchers and smes with a unique open science concept ensuring global medical impact finally within a 2year interphase repo4eu will be converted into a sustainable european infrastructure
logics and algorithms for a unified theory of hyperproperties

the central role of information technology in all aspects of our private and professional lives has led to a fundamental change in the type of program properties we care about up to now the focus has been on functional correctness in the future requirements that reflect our societal values like privacy fairness the central role of information technology in all aspects of our private and professional lives has led to a fundamental change in the type of program properties we care about up to now the focus has been on functional correctness in the future requirements that reflect our societal values like privacy fairness and explainability will be far more important these properties belong to the class of hyperproperties which represent sets of sets of execution traces and can therefore specify the relationship between different computations of a reactive system previous work has focussed on individual hyperproperties like noninterference or restricted classes such as khypersafety this project sets out to develop a unified theory for general hyperproperties we will develop a formal specification language and effective algorithms for logical reasoning verification and program synthesis the central idea is to use the type and alternation structure of the logical quantifiers ranging from classic firstorder and secondorder quantification to quantifiers over rich data domains and quantitative operators for statistical analysis as the fundamental structure that partitions the broad concept of hyperproperties into specific property classes each particular class is then supported by algorithms that provide a uniform solution for all the properties within the class the project will bring the analysis of hyperproperties to the level of traditional notions of safety and reliability and provide a rigorous foundation for the debate about standards for privacy fairness and explainability that future softwarebased systems will be measured against