Dragon09/odtu_chatbot huggingface dataset:
redoxdriven switches and motors

artificial molecular machines can not only exploit rotary or linear molecular motion to perform useful functions but can also elucidate the operational principles of natures biomolecular analogues which underpin a myriad of crucial biochemical processes electrochemically controlling these systems is a particularly promising approach to achieve a high degree of spatial control reusability sustainability and ease of interfacing with existing electrical nanotechnologies and can furthermore be utilised in solid materials or gels in spite of these advantages they remain considerably underexploredin this mscapf action we aim to address this challenge in developing redoxdriven conformational switches based on the overcrowded alkene bisthioxanthylidine btx as a result of their synthetic adaptability and versatile multistate switching properties redoxdriven btx rotors are ideally suited to complement or even surpass the ubiquitous lightdriven overcrowded alkene motors particularly in opaque and interfacial environments in order to develop this capability we propose the first systematic investigation into both the fundamental redoxswitching properties of btx derivatives and also for the first time demonstrate their utility in various proofofprinciple applications including switchable ionrecognition and stimuliresponsive interfaces this work will furthermore lay the foundation for the development of the first true unidirectionalredox driven overcrowded alkene motors a long soughtafter but thus far elusive goal these pioneering efforts will not only provide invaluable insights into the operational principles of redox switches and molecular machines in general but will also pave the way towards their exploitation in numerous industrial biomedical and environmental applications especially where lightdriven systems are not applicable
overturning size effects in ferroelectric thin films

the rapid increase in power consumption for data collection storage and processing drives a global interest in finding new energyefficient device paradigms ferroelectric materials can provide energyefficient solutions for targeted applications such as transistors based on polarizationinduced negative capacitance or memory devices based on polarizationcontrolled resistive switching the crucial properties of ferroelectricbased heterostructures in electronic applications are remanent polarization coercive voltage and leakage current because they limit the onoff ratio energy efficiency and charge transport properties of any device however uncompensated bound charge and defects at ferroelectric interfaces result in polarization suppression increase of coercive voltage and uncontrolled charge carrier formation the purpose of oseferroelectrics is to assess the possibility of tackling these size effects in ferroelectric thin films in oseferroelectrics i propose a path to an ambitious goal of overturning ferroelectric size effects by tailoring the heterostructure design and tracking the resulting crystal electronic and ferroelectric properties the two cornerstones of the proposal are i adoption of combination of scanningprobe and optical techniques to locally evaluate the crystal defect and ferroelectric properties and ii use of independent evaluation of electronic structure charge carrier concentration and mobility to understand the charge transport properties across ferroelectric interfaces the research questions and methods addressed in oseferroelectrics will advance the knowledge of ferroelectric size effects bring attention to semiconducting properties of ferroelectric layers and reveal routes for enhancing performance of ferroelectric memory devices ultimately the results of this project would have important implications for the integration of oxide ferroelectrics into the semiconductor industry
therapeutics based on the eaxon technology

within the eaxon project which is funded by an erc cog we have developed and demonstrated wireless microstimulators whose operation is based on rectification of volume conducted bursts of innocuous highfrequency current externally delivered through textile electrodes in contrast to previous implantable stimulation technologies apt for clinical use our technology allows the implementation of much thinner implants that can be minimally invasively deployed by injection our prototypes are threadlike with a diameter of less than 1 mm and consist of a silicone tubular body with two electrodes at the opposite ends and a titanium capsule in the middle that hermetically houses the electronics such a degree of miniaturization is possible because our technology avoids the need for bulky components within the implants eg batteries or coils the proposed poc project is essentially intended to facilitate the exploitation of this technology for therapeutics based on electrical stimulation
women tech europe support scheme

entrepreneurship is crucial for economic growth and societal progress yet women remain underrepresented in the field accounting for less than a third of entrepreneurs in eu this underrepresentation not only highlights inequality but also limits eus potential to tackle pressing challenges such as the digital green resilience transition and recovery from the pandemic deep tech sectors are even less balanced and investment for womenled companies remains less than 2 of the totalto address this gender gap women techeu will bridge collaboration between the european commission and paneuropean deep tech womenled startups to create a more genderbalanced entrepreneurship ecosystem built on the exisisting foundations of the eic women techeu initiative our consortium will scale this iniatiative with a clear perspective towards longterm sustainabilitywe will invest 12m in equityfree grants to 160 womenled deep tech companies and additional support services in a programme enhancing current eic bas to which we will linkthe consortium is comprised by partners covering all the expertise and geographies needed to reach over 15000 women entrepreneurs in deep tech from all over europe led by eit manufacturing it is strengthened with the participation of other kics from eit like health food and climate leveraging the power of their network and landmark events we also count with the expertise from sploro in cascade funding programmes across limits will guide the communication and dissemination activities as well as link in the service delivery with awaken hub who will coordinate an effort to evaluate over 1500 experts in 4 different open calls the consortium is complemented by major networks of investors and women entrepreneurs like eban afaemme wa4steam or fivalues and purpose driven we will search for sustainability and major impact of the initiative during the project and beyond even proposing a ppp structure to further exploit the project results
wilderness of time timescapes of contemporary us literature

the project wilderness of time timescapes of contemporary us literature wot proposes a novel and compelling interpretative framework for us fiction herein named wilderness of time and which arises from the need to promote a reading of us literature that truly acknowledges its impact in framing the world we live in wot reworks and reframes the symbolism of the wilderness by considering time as the dimension in which the wilderness experience takes place nowadays and by retracing this metamorphosis in contemporary literary texts by doing so it fills a gap in american studies broadening the conception of us identity and culture as seen through its literature starting from and going beyond its funding myths wot thus introduces an innovative perspective for both the scholarship concerning the study of time and temporality in contemporary us literature and that concerning the study of the wilderness envisioning new ways through which literature can serve as an agent for social change the research question concerns whether the combination of wilderness and time can provide a much needed framework to understand through literature how us identity has been changing as well as the impact of such changeboth within and outside its borders thus wot would enhance the importance of eu institutions as valuable teaching and research centers if not as counterenvironmental institutions in this field to be achieved also through the implementation of sustainable and inclusive teachingresearch tools in the present geopolitical context this will also bring a crucial contribution to a renovated european vision concerning current societal challenges engaging with universities in italy and in the us and making use of dh tools the project brings a significant contribution to american studies by introducing a novel approach on us literature and culture developed through creative and collaborative practices and methods for teaching and research in this field
digital tools and technology systems for the sustainable management of mediterranean forest resources

the med region includes more than 25 million hectares of forests and about 50 million hectares of other wooded lands climatic and socioeconomic changes in this region could have serious consequences for forests potentially resulting in the loss of ecosystem services and causing a wide range of economic social and environmental issues the low competitiveness of the forestwood supply chain in european mediterranean eumed countries is currently amplified by the missing or limited access of forest managers and companies to current and new digital technologies which appear to be out of date in certain key areas or fail to address some of the most pressing difficulties that the industry is expected to be confronting in the next decades this rationale calls for the urgent implementation of a multiactor approach to digitalization starting from recognizing stakeholders needs and subsequently defining joint actions to this end digimedfors overall goal is to transform the technological landscape of the mediterranean forestwood supply chain by increasing its competitiveness thus allowing the different stakeholders to better manage and supply multiple forest ecosystem services including the traceability of wood origin from forests to endusersin line with the eu forest strategy and the eu digital strategy digimedfor will employ advanced and innovative digital solutions to improve the monitoring and management of forest resources along the supply chain from their origin up to the wood industry optimising both the sustainability of wood production and traceability and delivery of ecosystem services digimedfor will address the synergetic use of geospatial ai and modelling technologies combining them with ict
next generation tools for genomecentric multimodal data integration in personalised cardiovascular medicine

healthcare is the fasted growing eu27 expenditure personalised medicine comprising tailored approaches for prevention diagnosis monitoring and treatment is essential to reduce the burden of disease and improve the quality of life integration of multiple data types multimodal data into artificial intelligence models is required for the development of accurate and personalised interventions this is particularly true for the inclusion of genomic data which is informationrich and individualspecific and more routinely available as the cost of sequencing continues to fall multimodal data integration is complex due to privacy governance requirements the presence of multiple standards distinct data formats and underlying data complexity and volume nextgen tools will remove barriers in data integration several cardiovascular use cases nextgen deliverables will include tooling for multimodal data integration and research portability extension of secure federated analytics to genomic computation more effective federated learning over distributed infrastructures more effective and accessible tools for genomic data analysis improved clinical efficiency of variant prioritisation scalable genomic data curation and improved data discoverability and data management a comprehensive gap analysis of the existing landscape factoring ongoing initiatives will ensure nextgen deliverables are forwardlooking and complementary nextgen embedded governance framework and robust regulatory processes will ensure secure multijurisdictional multiomic multimodal data access aligned with initiatives including 1 million genomes and the european health data space several realworld pilots will demonstrate the effectiveness of nextgen tools and will be integrated in the nextgen pathfinder network of five collaborating clinical sites as a selfcontained data ecosystem and comprehensive proof of concept
game changing deeptech removing barrier to farmed salmon production growth for climate planetfriendly low carbon footprint animal protein

globally the salmon aquaculture industry is worth circa 14 billion usd 2019 figures the main obstacle to further growth is the tiny sea louse konree innovation is developing a deeptech gamechanging and disruptive technology to tackle this the single most feared and persistent pest in salmon aquaculture the sea louse the sea louse is regulated everywhere it is farmed once the levels present reach the regulatory threshold it triggers treatment the direct cost to the industry in treatments for sea lice is approximately 1 billion usd 2019 figures while the indirect cost is estimated to be ca 3 billion usd mainly due to fish deaths brought about by weakening of the salmon due to sea lice induced wound infections and bacterial diseases therein as well as the nonoptimised handling of the fish during treatments up to 20 of production can be lost in this way konree innovation is developing a deeptech nonfishhandling solution that will employ both artificial and machine learning to outsmart the sea louses biological strategy for infestation the sea is a tough harsh environment the technology will need to perform well in this environment and do no harm to the fish in the pen the pen itself or the environment all these requirements demand a deeptech solution konree innovation is internationally focused norway has 56 of global production next chile at 28 north america at 7 scotland at 6 australia and new zealand at 24 ireland at 06 iceland and the faroe islands are now also farming atlantic salmon consumer demand for alternative climate and planetfriendly sources of protein is expected to get much higher and farmed salmon offers a highly nutritious source of animal protein with a low carbon footprint an effective way to maintain control and manage sea lice numbers will overcome the barrier to growth and enable the salmon producer industry to compete with the big meat producers that have a much higher carbon footprint
iguanabot bioinspired multimodal underwater robot for marine conservation

robotic systems in marine environments could enable highresolution measurements of ecological processes at extraordinary scales pushing the boundaries of current methods the inherent limitations of conventional propellerbased rov push for robotic systems with multiple modes of locomotion swimming and benthic locomotion in order to develop multimodal underwater robotics technology marine animals with both swimming and benthic locomotion capabilities serve as benchmarks in this project a bioinspired underwater vehicle called iguanabot inspired by marine iguanas will be developed with swimming and benthic legged locomotion capabilities the objectives of the project are to design and build the iguanainspired robot evaluate the robots performance in the laboratory and the field and do a case study by creating a 3d map of the seafloor that will aid in marine conservation these three objectives translate to six work packages multimodal locomotion system vision system integration and control verification and validation and a case study iguanabot will be the first underwater robot with unique technological features bioinspired swimming and legged locomotion in the natural marine environment a bendable back that adapts to irregular terrain and enhances locomotion performance and clawed feet that adhere to steep slippery substrates the robots development and performance optimisation will be performed at swedish maritime robotics centre kth royal institute of technology sweden the case study will take place at the sea close to gullmarsfjord a natural reserve in sweden stationing at kristineberg centre for marine research and innovation university of gothenburg
experimental production capabilities for quantum technologies in europe

the qupilot sga proposal consists of 21 partners from 9 different countries aiming to develop and provide access to the first federated european fabrication production capabilities for quantum technologies building on and linking together existing infrastructures in europe qupilot will implement the first stage of the capability innovation roadmap for providing experimental pilot production capabilities and a roadmap for transferring such capabilities to an industrial production environment as was proposed in the awarded fpa it will provide experimental production capabilities for quantum technologies in computing communication and or sensing through 13 serviceprovider organizations available to users including industry in particular smes and contribute to developing european standards in the field qupilot will provide services for the development of a european supply chain of quantum technologies provide european industry especially startups and smes with the necessary innovation capacity and make sure that critical ip remains within the eu the initial service offering will be validated through usecases with companies within the sga a minimum of 20 such usecases are expected and of those 11 are already part of this qupilot sga proposal the competence development industrial usecases and ecosystem building all the activities identified and set out in the fpa will have first set of implementation through this first sga
feast

feast food systems that support transitions to healthy and sustainable diets aims to support the eus just transition to healthy diets produced by sustainable food systems using a multiactor approach feast will leverage current best practice and codesign novel solutions with eu food system stakeholders including diverse vulnerable groups to identify how they can be supported and empowered to facilitate and benefit from the transition to healthy and sustainable dietary behaviour at all levels and in all sectors of the food system feasts objectives are1to better understand describe and measure barriers and facilitators that influence the dietary behaviour of different groups particularly vulnerable groups accounting for geographical socioeconomic behavioural gender and cultural differences 2to collaborate with key stakeholders in europes food systems to identify andor design and test innovative and effective tools programmes and strategies including social innovations that will enable consumers to make informed food choices that promote the selfmanagement of healthy and sustainable dietary behaviours and lifestyles3to empower individuals to adopt healthier and more sustainable dietary behaviours choices and lifestyles by means of evidencebased strategies and tools addressing all food system actors at the level of member states eu and wider international community4to increase the adoption of food and health policy interventions that aim to drive the transition to healthier and more sustainable diets by all stakeholders within the food system by designing and testing scientificallyinformed ommunication strategies and associated monitoring approaches that could be used by policymakersall stakeholders will be invited to our feast project and we will not accept that anyone is left behind or is left hungry and wanting because we do not believe in zerosum games we adhere to the principle that all must win
unravelling the role of pneumocystis jirovecii in utero infection in early and late pulmonary diseases of very preterm infants

very preterm birth represent about 1 of livebirths in europe each year and is associated with 58 of neonatal deaths and substantial lifetime health problems pneumocystis jirovecii is an ubiquitous microfungus commonly known for causing a severe interstitialpneumonia in immunosuppressed subjects however this could be the tip of the iceberg and compelling new evidences suggest thatthis infection may be pathogenic to certain groups of infantsin utero transmission of p jirovecii in humans has been recently proven the fungus has been found in the lungs of 1425preterm newborns associated with an increased risk of respiratory distress syndrome rds and bronchopulmonary dysplasia theability of p jirovecii to change the pulmonary environment has been demonstrated in other contexts inducing a modification of thehost immune response pulmonary dysbiosis and thickening of pulmonary alveoli genetic polymorphisms have also beenindependently implicated in both an increased risk of preterm bi or neonatal rds and a susceptibility to p jiroveciihence jiroborn aims to address the impact of p jirovecii in utero infection on the preterm infants lungs alteration and on thedevelopment of subsequent early or late diseases constructing a predictive model for monitoring preterm infants relatedpulmonary complicationsjiroborn is a nested case control study using a prospective cohort of 596 infected and uninfected preterm infants and their mothersfirst the clinical impact of p jirovecii infection will be evaluated for early and later lung complications then biological effects of theinfection will be studied focusing on the immune parameters the microbiota and on surfactant and mucus production genetic andepigenetic susceptibilities to p jirovecii colonization andor to the development of pulmonary diseases will be evaluated finally alldata will be analysed to build a predictive model for the monitoring of preterm infants pulmonary complications
reprogramming of tumor stroma to enhance cancer immunotherapy

cancer immunotherapies have shown impressive success in cancer treatment however these therapies are limited to certain type of cancers and success rate is still low in particular certain types of solid tumors containing an abundant stroma which represent a majority of epithelial derived cancer respond very poorly to immunotherapies in these tumors a major challenge for the development of novel cancer immunotherapies is represented by the tumor microenvironment tme a highly hypoxic and immunosuppressive environment which prevents proper tumor infiltration and functioning of effector immune cells recent discoveries identified tumoractivated mesenchymal stromal cells mscs developing within the tme and showed that they represent a major brake for efficient antitumor immunity in solid tumors in this project we will investigate the potential of a novel approach and therapeutic avenue to target specific populations of mscs within the tme and determine the synergistic effect with immunotherapies to improve treatment efficacy in solid tumors in the long term this project aims at overcoming a major barrier in utilizing cancer immunotherapies in solid tumors