Dragon09/odtu_chatbot huggingface dataset:
satcom and 5g link edge cyber telecommunication

the s5lect satcom and 5g link edge and cybersecurity project coordinated by sncf and developed by railenium gts france thales radiolabs and ceit will experiment a solution for seamless handover between 5g terrestrial network satellite link and gsmr communication system in the automotive and rail domains vehicles are entering the era of full automation thanks to wireless sensors and communication systems shifting control functions from the human driver to computers railways need to increase functionalities of the existing signalling and automation systems and related design and validation processes therefore providing a more competitive flexible realtime intelligent traffic management and decision support system those technological innovation will help railway to answer his ambition to increase rail traffic with the future ato and frmcsthe consortium will study the hybridization of terrestrial and satellite communications networks for railway critical applications the project will last 30 months and is tailored to define and develop an innovative solution for seamless handover between terrestrial and satellite communication networks to assess cybersecurity risks and propose solutions to propose innovative architecture for edge computing and finally to provide a proof of concept of all the bricks developed in the project thanks to an original laboratory testing platformthe s5lect project will directly contribute to the development of solutions for the use of govsatcom satellite communications in the railway domain it will also contribute to the development and testing activities to deliver more reliable and robust wireless communication prototypes this should help to enhance the testing activities and minimize time and efforts to deliver the next generation of adaptable wireless communications for all railway segments
intelligent neural system for bidirectional connection with exoprostheses and exoskeletons

the main goal of the proposal is to develop a new generation of bidirectional implantable electrodes connecting the human nervous system with external mechatronic aid devices such as exoskeletons and exoprostheses thus helping people with arm amputations or leg paralysis regain their motor and sensorial functions electrodes will be the primary bidirectional interface to the nerves followed by the implantable module comprising an asic for signal processing a microcontroller an antenna for radio communication a coil for wireless power charging and a supercapacitor for energy storage to enable data communication to the mechatronic structures as well as their power management and control via ai modules an embedded system will be designed fabricated and tested this system will then be integrated into the mechatronic structures of exoprosthesis or exoskeletons due to the presence of bidirectional implantable electrodes a close loop between the users brain and the devices control system will be created with the ai module being used to learn and interpret the users synaptic signalsall the components and modules will be designed fabricated and tested with demonstration being assured by integrating the neural implantable systems with exoprostheses and exoskeletons into three demonstrators aimed at different categories of patients with forearm amputation with lower limbs paralysis and with single leg paralysis a new generation of exoprostheses and exoskeletons controlled by the patients brain via the nervous system will change the paradigm of support for people with disabilities and will have an important social economic medical and technological impact the technology advances including miniaturization wireless communication and power supply progresses in medical microsurgery tools and methods new biocompatible materials and technologies will considerably contribute to the project implementation
cognitive aspects of mithraic rituals in pannonia

traditional scholarship focusing on the examination of archaeological material from the roman province of pannonia has ignored cognitive and sensory theoretical approaches particularly when it comes to the study of roman religion and ritual although the cult of mithras was extremely popular in roman pannonia we still know little about 1 how ritual practices were learned performed remembered diffused and transformed between different mithraic communities in pannonia and 2 how mithraic religious networks were formed my research project aims to bridge this gap in scholarship by applying interdisciplinary cognitive and sensory theoretical perspectives to the analysis of archaeological epigraphic and iconographic evidence for the cult of mithras from various pannonian settlements in order to investigate and answer 1 and 2 i hypothesize that the project will demonstrate that mithraic communities throughout pannonia exhibit localized variations of ritual practices thereby challenging traditional interpretations of homogeneity of mithraic ritual the project will be developed as a series of case studies where evidence from mithraic communities and settlements across pannonia will be analyzed compared and contrasted these case studies will be published in the form of peerreviewed articles the university of vienna is the ideal place to conduct this research firstly because of viennas archaeological heritage as an important roman pannonian settlement secondly because of viennas museums archives and libraries which hold austrohungarian excavation reports and archaeological materials and thirdly due to viennas strategic location on the roman danube frontier and its proximity to many other pannonian archaeological sites most importantly collaboration with prof dr günther schörner a leading international scholar on roman rituals and cognition will enable me to broaden my research expertise and contribute to research output at univie
scalable processing of highly stable flexible multijunction perovskite solar cells from green inks

this proposal develops perovskite solar cells pscs as a transformative power conversion technology by addressing critical challenges related to stability and scalability the key objectives are1 translate a lowtoxicity precursor ink and 2dtemplated crystallisation method recently developed by the applicant from laboratoryscale to scalable manufacturing processes use this method to produce flexible singlejunction pscs with 20 efficiency compatible with lightweight internet of things applications2 explore 2dtemplated fabrication of a range of complex mixedion halide perovskites with bandgaps ranging from 1220 ev using a combinatorial slotdie coating approach pioneered by the host group highthroughput ink and process optimization will be achieved followed by indepth investigation and enhancement in compositional stability of the perovskite phases formed having optimised singlejunction cells of relevant bandgaps multijunction devices will be scalably fabricated3 recognizing that degradation in pscs often occurs at interfaces between the perovskite layer and adjacent materials in the cell conduct a systematic investigation to understand and mitigate degradation mechanisms in our single and multijunction pscs employing luminescence mapping we will first spatially identify interfacial instabilities evolving in pscs under operational aging having identified stabilitylimiting interfaces solidstate nuclear magnetic resonance spectroscopy and timeofflight secondary ion mass spectrometry 3d mapping will allow us to analyse interface degradation at the atomic level providing mechanistic insights into active degradation pathways based on this investigation a tailored range of stability enhancement strategies will be used to enhance psc stabilitywith these objectives this proposal will advance commercial implementation of psc technologies paving the way for more efficient costeffective secure and renewable energy solutions
multianalyte continuum nanopores sensing

diagnostic limitations in healthcare form a major societal challenge especially in the case of heart failure more than 15 million europeans suffer from heart failure with a projected increase of up to 33 in heart failure patients globally by 2060 an important instrument for better diagnoses of heart failure comes from natriuresisguided therapy offering potential for personalized treatment monitoring natriuresis through urinalysis via point of care testing poct helps manage severe heart failure however poct presents several complications as it can only be performed by health care professionals and longterm costs are high responding to these challenges this erc proof of concept poc proposal introduces multianalyte continuum nanopores sensing mcnano led by prof giovanni maglia mcnano aims to develop a biological nanopore tool for realtime continuous patient health monitoring to improve possibilities of poct mcnano will develop a nanopore system to detect sodium ions electrolytes proteins and heart failure biomarkers in liquid samples like urine by utilising multiple nanopores the system improves accuracy and reliability in identifying pathologies related to heart failure including kidney failure the projects advantages include its potential for miniaturisation minimal need for specialised solutions and compatibility with lowpowered electronic devices built upon the foundations of a previous project erc cog denano which successfully developed biological nanopores for peptide and protein sequencing this proposal aspires to take the first steps toward the design of an innovative diagnostic device tailored for continuous monitoring of heart failure patients tracing natriuretic activity in realtime the resulting technology aims to substantially reduce the limitations of current diagnostic methods for heart failure patients globally and paves the way for precise and efficient medical interventions in the future
spatiotemporal integration of skin inflammation

to feel comfortable in ones own skin is an idiom referring to ones confidence in interacting with others however when the skin is inflamed as in atopic dermatitis or psoriasis patients carry a substantial burden leading to opposite effects current therapies target redundant latestage inflammatory events but not the disease drivers leading to heterogeneous and insufficient efficacy understanding the proximal mechanisms of inflammation will stimulate the development of better therapiesamong the innate immune sensors for stress and microbes in keratinocytes mutations in the nlrp1 and nlrp10 inflammasomes are linked to skin disorders these molecules and the pro and antiinflammatory il1 family members they regulate are differentially expressed in the different layers of the epidermis we hypothesize that inflammasome signaling in keratinocytes needs contextdependent and spatiotemporal control to avoid inflammation which poses unique analytical and conceptual challenges therefore to understand how inflammasome signaling in specific keratinocytes drives skin inflammation 4dskinflam will i optogenetically activate specific inflammasome components with spatiotemporal precision and perform a spatial analysis of transcriptomes and proteomes in neighboring cells with lossoffunction approaches and pathway activity reporters we will ii define the sensome and the activity of inflammasomes in different areas of the epidermis using mouse models we will iii evaluate how spatial inflammasome activity drives skin inflammation through iv aidriven deep visual proteomics combined with an analysis of inflammasome activity we will discover spatial inflammasome activation and its effects in inflammatory skin disorders a precise understanding of spatiotemporal inflammasome signaling in the skin will be critical for selecting therapeutic targets acting as upstream drivers of prevalent diseases with high unmet needs
material and environmental legacies in the 21st century a theory of legacymaking between generations

human legacies are more important and influential than ever before because the window of opportunity for generational interaction has been greatly extended due to longer life expectancies and because legacies assume unprecedented importance in a world marked by inequality and environmental degradation the legacies project arises from my original proposition that legacies are not only posthumous and concern older people and their heirs but they are dynamic intergenerational processes comprising material and immaterial dimensions material legacies wealth assets that are transferred from one generation to the next are growing greater in volume than ever and highly influential in shaping life courses in addition to material inheritance we also leave immaterial legacies values manifest in actions the most pressing of these being our environmental legacies the legacies project will break new ground in understanding the intertwined material and environmental legacies that pass between coexisting generations my approach is inherently highrisk due to its novelty in straddling multiple generations and the societal and environmental spheres in diverse contexts the potential scientific gains from this research connect to widereaching implications shedding light on what drives older generations legacymaking practices will allow a better understanding of the dynamics of inequality understanding the interconnectedness of environmental and material legacies will elucidate choices such as deciding against having children and their ramifications on inheritance practices illuminating how environmental legacies are shaped through generational interaction will better equip us to formulate effective agendas for combating environmental degradation the legacies project will yield concepts and theory essential for explicating how strategies and practices at the micro level reflect and shape the greatest challenges that humans and the natural environment face
birgejupmi bridging knowledge systems for inclusive resilient and prosperous arctic coastal futures

the birgejupmi project aims to strengthen community engagement and relational environmental decisionmaking in arctic coastal regions by bringing together diverse knowledge systems indigenous western and local grounded in a holistic ethical and equitable communitybased approach to research with strong indigenous leadership empowering communities to use and develop their own knowledge is vital for fostering resilience cultural preservation socioecological wellbeing and mobilizes coastal communities to address local challenges effectively while promoting social cohesion to this end birgejupmi focuses on three arctic areas western spmi northern spmi and kalaallit nunaat greenland following three objectives 1 document revitalize and integrate indigenous peoples knowledgeinformed practices connected to marine and coastal resources management and conservation in fjord socioecosystems and inform decisionmaking processes for coastal management and governance models rooted in traditional ecological knowledge tek 2 assess the environmental socioeconomic cultural and demographic changes experienced by arctic coastal communities in relation to climate change adaptation and mitigation measures focusing on young peoples visions for a sustainable future and their involvement in regional national and eulevel environmental decisionmaking 3 investigate the transformative potential of sea and landscapes as living archives to inform tekrooted resource governance and empower local institutions and knowledge centers to become open spaces for dynamic communityled research the role of indigenous art handicraft and artbased methods is highlighted as they contribute to healing reconciliation and environmental coping mechanisms in arctic coastal regions birgejupmi is grounded in indigenous methodologies and adopts a coproduction of knowledge cpk and twoeyed seeing approach to advance decolonial research and responsible policy
asymmtric copperi catalysis in artificial metalloenzymes

the proposal that cucatarms asymmetric copperi catalysis in artificial metalloenzymes aims to design and develop a proficient artificial metalloenzyme which contains a low oxidation state copper cui center enabling a series of enantioselective newtonature transformations in a protein environmentthe roelfes group has been engaged in creation of lmrr based arms for the asymmetric coppercatalyzed newtonature reactions reliable approaches have been developed by the roelfes group to efficiently recruited the copperii species to the lmrr pore either introducing metal binding unnatural amino acids through in vivo stop codon suppression or supramolecular assembly via the stacking interaction between tryptophan moieties and metal complex our approach is enabled by reducing the copperii center which is chelated by anchoring moiety of lmrr to copperi center with mild and efficient reductants in situ objective 1 this design of copperi catalysis in lmrr based artificial metalloenzyme will be exploited to develop the following objectives objective 2 asymmetric conjugate addition of alkynes objective 3 asymmetric intramolecular cyclopropanation objective 4 apart from developing the novel methodologies we will also devote ourselves to reveal the detailed mechanism aiming to provide theoretical guidance for future works overall the successful development of cucatarms project will represent a proficient strategy to apply low oxidation state transition metals in enzyme catalysis the results of the project will inspire the development of cccn bond formation reactions through copperi catalysis in arms and offer new strategy for the organic chemistry and material communities when planning a synthetic route for a specific target
observing the mechanisms of earthquake nucleation

earthquakes are one of the most expressive phenomena of our planet able to suddenly reshape the surface of the earth and affect countless lives every year any effort towards earthquake forecast and hazard mitigation must rely on a profound comprehension of seismogenesis however earthquakes are phenomena that emerge from a complex dynamic system of mechanisms that operate at inaccessible depths within the earth the impossibility to directly observe the birth of an earthquake ie the nucleation frustrates our effort to have new breakthroughs on their physicsthe overarching goal of omen is to directly observe the mechanisms of earthquake nucleation to allow for a stepchange in our understanding of seismic slip and its potential precursors omen will overcome the current experimental approaches that rely only on the indirect measure of sample properties andor use of rockanalogue materials with an innovative rockdeformation apparatus and the use of transparent hightech glass i will be able to simulate and for the first time film the birth of earthquakes in natural fault rocks at hypocentral conditions this method in combination with several investigation techniques visible and infrared footage acoustic emissions deep learningassisted image analysis etc will offer unprecedented detail on the processes during the preparation and propagation of seismic slip in particular i will shed new light on how the complexity of natural rocks affect the dynamics resulting into the formulation of a new more reliable physical framework for the description of earthquake nucleation laboratory and theoretical results will be upscaled to nature thanks to the integration of microstructural and field studies of natural faults omen is the unique opportunity to open a literal window into the dynamics of earthquakes shifting the paradigm from an empirically quantitative documentation to a direct and truly quantitative observation
chemical rewiring of e3 ubiquitin ligases as a generalizable therapeutic approach

classical drug design relies mostly on the availability of accessible pockets to block specific protein activities despite tremendous progress more than 80 of all human proteins remain beyond the reach of traditional inhibitorcentric approaches chemical ablation of protein abundance using bivalent degraders protacs moves away from an occupancydriven inhibition to an eventdriven binding pharmacology however their design is intrinsically limited to targets that are ligandable via chemical probes to tackle current unmet clinical problems we need transformative paradigmsfortuitous discoveries have illustrated the immense potential of monovalent degraders these molecules induce the degradation of target proteins by molecular gluing to e3 ubiquitin ligases or by prompting their destabilization they have desirable druglike properties proven capacity to induce the degradation of proteins otherwise deemed undruggable and they are already a clinical reality however their discovery has been driven by serendipity thereby hampering their realization as a generalizable drug solutiontricke3 seeks to establish the foundations for the systematic development of monovalent degraders to this end we will develop innovative methodologies to detect and predict druginduced changes in the interactomeactivity of e3s at scale as proof of principle we will focus on the chemical rewiring of e3s expressed in pancreatic ductal adenocarcinoma pdac due to the imperative need for treatments we intend to prospectively identify monovalent degraders i of specific vulnerabilities and ii to unlock new pdac targetsat the interface of chemical biology and cancer research tricke3 will be an instrumental resource to broaden drug discovery efforts probe diseaserelevant vulnerabilities and overall widen the targetable space of the human proteome we hope to empower other disciplines to chemically explore without limits the degradation of relevant targets
nextgeneration heart bypass grafts to naturally restore cardiovascular function

coronary artery disease is caused by narrowing of heart arteries that supply blood often due to atherosclerosis coronary artery bypass grafting cabg is the gold standard surgery to treat it and it commonly involves harvesting patients veins from the legs as grafts this collection affects patients causing chronic pain and costly complications it also has a high failure rate with 20 implants occluded after 1 yearxeltis has developed a unique restorative vascular graft xabg that eliminates the need for vein harvesting the implant provides a homing structure for cells in which cardiac and vascular tissues can be naturally restored with the related advantages and benefits for patients and the healthcare system we have proven our technology in first niche applications as well as completed preclinical studies successfully for xabg now we plan to perform a full clinical validation to obtain a ce mark in europe and start market deployment and commercial upscaling