Dragon09/odtu_chatbot huggingface dataset:
towards constraining the pillars of our cosmological model using combined probes

despite the observational successes of the lambda cold dark matter cdm cosmological model a number of its key ingredients remain unknown imminent surveys promise to yield unprecedented constraints on these components thus making precision tests of cdm a firsttime realityin pico my team and i will focus on two fundamental questions in modern physics that can only be answered through cosmological observations what mechanism gave rise to the primordial fluctuations seeding all the structures seen in the universe today what is the cause for the universes latetime accelerated expansion we will address these by developing novel analysis techniques built on the complementarity of cosmological probes and advanced statistical methods these are designed to harness the rich information contained in nongaussian smallscale features of cosmic fields while enabling precise constraints on cdm robust to systematic uncertainties dominating highprecision data focusing on two of the most powerful probes of the next decade galaxy clustering and galaxy clusters we will constrain the mechanisms driving the accelerated expansion through the first joint simulationbased inference analysis of galaxy clusters selected through the cosmic microwave background cmb and weak lensing in addition we will derive constraints on primordial fluctuations in a combined analysis of galaxy clustering and cmb lensing angular two and threepoint statistics capitalizing on my past work we will develop these methods using simulations and current data before applying them to galaxy data from the rubin observatory legacy survey of space and time and cmb data from the simons observatory two upcoming highprecision experiments i am deeply involved in pico will deliver tight constraints on the key ingredients of cdm and will thus contribute to understanding if this model provides a complete description of our universe or if it is time for a paradigm shift in cosmology
development of biocatalytic strategies for the synthesis of chiral thiols and thioethers

active pharmaceutical ingredients apis are crucial for public health however their synthesis is often challenging due to the high complexity of modern drug molecules in particular apis need to have welldefined chirality as opposite enantiomers can have dramatically different biological effects yet the synthesis of chiral centres is often challenging and toxic metals as well as harsh reaction conditions are often required enzymes on the other hand can often achieve unmatched enantioselectivities while also avoiding such environmentally unfavourable conditions while several biocatalytic strategies for the synthesis of chiral alcohols and amines have been developed few such strategies exist for the synthesis of chiral thiols and thioethers despite 20 of all apis containing sulfur in the project described herein i will be developing biocatalytic approaches for the synthesis of thiols and thioethers by exploring promiscuous activities of classes of enzymes widely used in industry this will expand the tools available for their synthesis and open up new routes and new chemical space for the synthesis of apis and improve the sustainability while working with dr caroline paul in the biocatalysis group at tu delft i will receive training in handling nicotinamide and flavindependent oxidoreductase enzymes as well as specialist computational tools for enzyme engineering while providing my experience in highthroughput screening and chemical synthesis i will have the opportunity to cosupervise bachelor master and phd students and attend several key conferences this will allow me to further develop the necessary scientific and teaching skills that are required for leading my own research group
a general approach for the design of covalent protein proximity inducers

chemical biology has made remarkable strides over recent decades producing potent and selective inhibitors for many proteins including essential drug targets despite these achievements however inhibition has been the primary mode of perturbation gpcrs notwithstanding whereas many biological processes are controlled through a rich spectrum of biochemical perturbations what if a small molecule could activate an enzyme install or remove a posttranslational modification ptm or control its oligomeric statethe overarching goal of this proposal is to dramatically increase the scope and breadth of perturbations and ptms one can induce in cells using small molecules accomplishing this will have tremendous impact on the ability to investigate numerous cellular processes and holds massive therapeutic potentialto achieve this goal we will build on our recently developed covalent liganddirected release coldr chemistry which allows totag proteins covalently while preserving their function our research will develop1 a general method to create coldrbased probes against a panel of targets that would enable us to harness their activity forselective perturbation of new nonendogenous substrates2 homodimeric coldr probes to induce selective dimerization of targets this will allow us to selectively activate targets such askinases in cells we will also design protein polymerizers by tethering obligatory homodimers3 chimeric proximity inducers that would selectively modify new targets in vitro and in cellsour groups experience in covalent chemical biology proteolysistargeting chimeras and the development of the coldr platformmakes us uniquely positioned to create the next generation of covalent proximity inducers
support utilisation of sustainable and tailored innovative methods for hta

with everincreasing complexity of novel health technologies health technology assessment hta methodologies have been evolving rapidly however there is now a lack of harmonization on the methodological needs of hta bodies against the varied methodologies and tools there is a need for a solution that allows for continuous dialogue between hta bodies and academia a solid unified base for implementation of fitforpurpose methodologies and longterm upskilling on hta expertise sustainhta aims to upskill the paneuropean hta body workforce and harmonise hta expertise via a robust education and training framework that ensures continuous uptake of novel needbased hta methodologies aligned to the methodological developments as part of the new eu hta regulation the project will set up a mechanism for dialogues and interaction between hta bodies and academia to regularly assess htabodies needs in parallel with a methods observatory that ensures uptodate knowledge of latest hta methods prioritized methods will be piloted within hta bodies and after endorsement implementation will be supported by a harmonized training and education framework that will be established to upskill the hta experts a longterm dissemination and communication structure among all stakeholders will be established to guarantee a feedback loop between hta needs methods assessment and associated training needs via the collaboration of 5 universities 7 hta bodies 2 smes and one nonprofit organization sustainhta brings together extensive experience in coordinating previous european funded htarelated projects including htx ehden comed and getreeal with this sustainhta has the background for establishing sustainable business models that ensures continuity of project outcomes and activities in years beyond the project sustainhta will support european leadership in the hta field reach hta bodies across at least 15 european countries with hundreds of people upskilled
toward perovskitebased electrically pumped laser via facile facet engineering

beyound traditional iiiv laser diodes solutionprocessable solidstate lasing spssl has been in spotlight due to promising versatility and simplified fabrication for integration into various platforms among the classes of optical gain media organic materials colloidal quantum dots cqds and perovskites have been extensively explored while organic materials have shown promise challenges remain in addressing triplet and polaron losses cqds on the other hand have demonstrated significant progress in suppressing undesirable loss mechanisms perovskites a rising material present distinct advantages including ease of formation through roomtemperature processes and remarkable optical properties low threshold of ase and continuous wave lasinghowever two primary challenges face perovskite implementation firstly there is a notable gap in fundamental studies specifically in understanding the correlation between auger recombination and optical properties secondly the softionic nature of perovskites poses a challenge for surface shell modification necessitating the development of suitable treatment methodsthe research aims to achieve electrically pumped amplified spontaneous emission through a comprehensive study of perovskites and the introduction of a novel modification strategy the project encompasses three objectives understanding the correlation between compositions and ase thresholds maximizing the optical properties of perovskite nanocrystals pncs through surface etching and facet reconstruction and implementing pncs into leds with a focus on modulating joule heating and introducing distributed bragg reflectorsoverall this research endeavors achieve worlds first electrically pumped ase using perovskite offering a promising avenue towards efficient costeffective and widely applicable laser diode technology
fundamental study of co2 storage through microbially enhanced carbon mineralization co2forearm

largescale implementation of geological carbon sequestration is considered as a key strategy to limit anthropogenic warming to 15 2 c as set out in the paris agreement i am interested in a viable alternative represented by injecting co2 into reactive rock formations eg basalts to facilitate rapid carbon mineralization and therefore increase storage security my particular interest lies in microbially enhanced carbon mineralization biological catalysts are utilized to alter reaction rates and further enhance carbon mineralizationthe overarching aim of this projects research is to provide the fundamental understanding and simulation technology required to assess the largescale deployment of co2 storage through microbially enhanced carbon mineralization and hence contribute to climate change mitigationthe project brings together engineers biologists and environmental scientists from spain and italy to undertake a comprehensive research programme comprising combined experimental computational and theoretical investigationsi will derive models both at the conceptual and the numerical level necessary to understand the dominant processes and develop a suitable simulation framework the computational studies will employ various numerical techniques combining multiscale modelling and conventional cfd to investigate the flow physics and co2rockbiomass interactions at subpore levelscomplementary experiments on flow and mineralbiomassfluid interactions will be conducted at polimi aiming at characterizing biofilm growth in porous microstructures using microfluidic devices that can capture spatial flow heterogeneities and chemical gradients at the porescalethe ultimate aim of the investigations is to use the new experimental and computational data to produce correlationsrelationships for use with large scale simulations as well as developing further fundamental understanding of phenomena of co2biomass reactive flow in porous media
isotopically labelling of cell surface glycans to illuminate infectious processes at atomic resolution

every human cell is covered by a dense coat of glycans sugars carbohydrates sugars are the first molecules that viruses encounter when they approach host cells many viruses encode lectins to adhere to the outer glycan layer and start infection in this scenario glycoscience holds a tremendous potential for combating infections elucidating the molecular basis of infection is essential but far from trivial the complexity of the chemistry of glycans including synthesis structure conformation and dynamics hampers the full knowledge of sugarmediated recognition events and the development of glycanbased drugssurfing the current information on glycanlectin interactions we stumble in contradictory outcomes pointing out the tremendous difficulty of translating in vitro results to the in vivo environment which limits the translation from the bench to clinicsi propose an unprecedented strategy to untangle the key glycans molecular interaction features breaking the limits in answering fundamental questions related to sugar structure presentation dynamics and eventually function i will chemically remodel the glycans directly on the cell surface using nmr active probes to decode their roles at atomic resolution while preserving their presentation in a neartoinvivo environmenti am in a favoured position to accomplish this project due to my experience in nmr synthesis and mammalian cells manipulation i will combine chemical biology tools novel chemical and enzymatic synthesis and nmrbased methods from chemistry to biology and beyondglyco13cell will gap down the observed differences between in vitro and in vivo results paving the way for develop novel glycanbased tools for predicting diagnosing and treating infectious diseases now its time the increasing understanding of infection biology with the atomic precision of modern chemical tools will make glycomics run in parallel with genomics proteoms towards personalized medicine
a metagenomicbased precisionmedicine tool for personalized diagnosis prognosis and treatment of oral diseases

about 20m dental implants are performed globally per year implant market valued at 36b in 2020 is growing at a cagr of 11 unfortunately microbiomebiofilmassociated diseases can affect dental implants compromising oral and systemic health more than 50 of implant patients develop mucositis an inflammation of the soft tissues which may lead to periimplantitis a severe infection affecting soft and hard tissues that can lead to implant loss currently there are no reliable tools to assess disease severity and risk of disease progression and the dentist can only prescribe empirical therapies without knowing the composition of the triggering periimplant plaque microbiome at prebiomics we developed a precisionmedicine test that characterises the microbial composition of the plaque biofilm collected in the area surrounding the implant in 10 years of research we have shown that specific bacterias presence is key to predicting the infections severity and progression prebiomicspmt will develop a test using metagenomics and an ai algorithm which will enable the implementation of monitoring and diagnosis and provide treatment recommendations for each patient based on the bacterial composition of their plaque microbiome based on the results of the erc pocs pb3p this eictransition project aims at automating the workflow using a robotic solution to reduce the costs of the service and speed up the results building an extensive database that will be used to create an antibiotic resistance panel and further develop our decision support system dss for dentists finally conducting a validation study to prove the predictive power of our dss alongside the technical development we will define the ipr management plan to protect the knowledge we continuously generate study indepth the dental implants market and the needs and expectations of our customers and investors and elaborate a robust business plan to allow proper exploitation of our product
motion control systems of multiactuated ground vehicles

moco is based on an intensive staff exchange to promote joint research and training between 14 universities and industrial companies from 8 european countries japan the republic of korea mexico and south africa the proposal innovates the methods of motion control and creates a comprehensive framework for the design identification and validation of systems for the domain of multiactuated vehicles with a focus on driving and functional safety energy efficiency driving performance and ride comfort moco is dedicated to improving the robust operation of automated and electric vehicles under various driving conditions including uncertain road surfaces severe conditions and terrains as well as scenarios characterised by limited information and communication infrastructures research and innovation activities will focus on the followingi development of sophisticated tools for estimating parameter variations and identifying system characteristics using hybrid modelbased and datadriven methodsii design of advanced vehicle motion control systems considering automated driving functions multi actuated configurations and different electric powertrain topologies using robust and predictive approachesiii validation and verification of realtime software and hardwarebased demonstrators using stateoftheart methodsiv facilitate practical recommendations based on the moco results for researchers oems and suppliers working on automotive and interdisciplinary applicationsv professional development of participating research and engineering staffvi knowledge transfer and promotion of the exchange of expertise between the partnersin addition to research and training the project will focus on relevant networking dissemination and exploitation initiatives to maximise its impact moco will cultivate the necessary competences and skills that are essential to foster successful innovation in the emerging mobility domains
automata dynamics and actions

this project lies at the nexus of complex and symbolic dynamics group theory decision problems and computation it aims to solve major problems in each of these fields by means of automatic actions and relationsfinite state automata pervasive in theoretical computer science will serve to define selfsimilar mathematical objects and produce efficient algorithms to manipulate them i will explore a novel notion of automatically acting group encompassing the previously unrelated notions of automatic groups automata groups and substitutive shiftsgeometric group theory propounds the vision of groups as geometric objects a basic notion is volume growth and milnors still open gap problem asks for its possible range in this proposal i will give candidates of groups with very slow superpolynomial growth defined by their automatic action on dynamical systems and a proof strategya celebrated open problem by gromov asks whether all groups are sofic this property has too many valuable consequences to always be true yet there is no known nonexample i will present a strategy of producing nonsofic groups closely associated to automatarational maps on the riemann sphere provide a rich supply of dynamical systems a fundamental goal is to give a combinatorial description of the dynamics across families of maps constructing models of parameter space i will encode the maps via automatic actions and study relations between automata to produce such models i aim to achieve a full topological description including the longopen connectedness problem of milnors slices of quadratic mapsthis project will tackle these fundamental questions from group theory and dynamics and develop presently unexplored interactions between them through a unified use of automata it will prove decidability of certain algorithmic problems such as dehns and tarskis and construct efficient tools to further our exploration of these mathematical universes
center for digital text scholarship

rapidly expanding developments in computational methods and capacity in recent decades have significantly and sustainably changed the opportunities that humanities disciplines have at their disposal to carry out effective investigations using textbased data this subfield of digital humanities research is particularly relevant for linguistics literary scholarship folkloristics and history and yet relevant modern methodologies for computational approaches to processing textual data for humanities research are often practiced and taught in a fragmented individualistic way the very recent arrival of generative ai and llms promises even more opportunities but these uncharted waters are still waiting for exploration and potential exploitation in the humanities especially concerning smaller lesssupported european languages this erachair project will permanently improve this landscape in europe by creating the center for digital text scholarship digits as an interdisciplinary pocket of excellence at the university of tartu in estonia for applying cuttingedge computational methods in textbased humanities research at the european periphery prof maciej eder a renowned expert in expert in computerassisted text analysis will lead digits and its international interdisciplinary team in carrying out worldclass humanities research using established and novel methods in neural networks and data analyses for exploring textual data in addition the team will teach the next generation of estonian and other european humanities scholars in these methods at ba ma and phd levels and also consult dh researchers at all levels simultaneously the center will promote the creation and application of llms for estonian as an exemplary smaller european language these activities combined with collaboration with humanities researchers in other institutes and consortia will ensure that utartu becomes synonymous with textbased digital humanities research
protesting the global air transport industry social movements fighting for the preservation of local communities and the planet

protestairt is a multiactor and interscalar research project aiming at understanding the growing global and european dissent against the air transport industry before the pandemic air transport was expected to growth at a rate of about 4 per year including both more frequent flyers in developed nations and new markets in the developing world this future demand was paired with new infrastructural projects namely new airports and airport expansions recently several social movements have been campaigning in europe to create awareness about the series of side effects associated to this global industry from aircraft noise to co2 and nonco2 emissions airports have become both the site and objects of diverse forms of dissent as sites of dissent airports have been the place where activists congregate and exert their democratic rights through claimmaking oftentimes engaging in radical and performative protest acts as object of dissent the narratives about airports and airlines as spacescompanies of interconnection and development have been challenged by these dissenting citizens proposing alternative readings of airports and airlines as spaces of destruction and overconsumption the protestairt project focuses on selected cases of european activism that target the global air transport industry including collectives such as schipholwatch in the netherlands am boden bleiben in germany extinction rebellion in united kingdom zeroport in spain and the umbrella organization stay grounded which connects action groups from all over the world protestairt will be based on media texts indepth interviews visual documentation of acts of dissent through participant observation analysis of social media data in specific of twitter as political platform and secondary literature produced by airports airlines and social movements alike the project will study the ongoing debate apropos potential solutions for the aviation industry and their limits