Dragon09/odtu_chatbot huggingface dataset:
learning the interaction rules of antibodyantigen binding

antibodyantigen binding is the basis of two fundamental biotherapeutic pillars monoclonal antibodies 1 and vaccines 2 to accelerate therapeutics discovery we need to perform antibody ab and antigen ag design in silico specifically we need to address a fundamental immunobiotechnological challenge understanding the interaction rules that predict abag binding solving this challenge demands the convergence of biotechnology computational structural biology and machine learning ml my lab is one of the few worldwide to have this transdisciplinary expertiseresearch problem currently the predictive performance of abag binding is poor and an understanding of the underlying rules of abag binding is mostly absent we previously showed that both unprecedentedly large datasets 105 abag sequence pairs and extensive structural information on the abag binding interface paratope epitope are needed to increase prediction accuracy and recover binding rules targeted breakthrough to address the lack of largescale abag sequence and structural data we will develop a method for highthroughput screening of 103 ab paratopemutated variants binding to 103 of ag epitopemutated variants generating sequence data of abag binding pairs at an unprecedented scale 106 sequence abag pairs structural information of the entirety of the sequencebased abag binding data will be generated by building and innovating on recent breakthroughs in computational structural biology to derive abag interaction rules from the generated data we will develop ml techniques for abag binding prediction and rule recovery we will demonstrate experimentally that we have begun to understand abag interaction rules impact the proposed research generates the exact data necessary to recover the rules of abag binding and provides a first groundbreaking insight into those rules moving us closer to in silico ondemand antibody and vaccine design
transforming education for democracy through aesthetic and embodied learning responsive pedagogies and democracyasbecoming

democracy is a lived experience to flourish democracy needs healthy roots in peoples engaged feelings awareness and sensibilities as embodied beings connected with each other and their localities communities and the natural world democracy cannot be understood and enacted simply through cognitive learning or technical interactive skills yet education for democracy gives little attention to nurturing those aesthetic affective and embodied roots of democracy this is because the learning theory on which most education for democracy is based omits a fundamental dimension of learning that is the aesthetic and embodied nature of learning the ambition of this project is to remedy this omissionthe project will design an innovative evidencebased aesthetic and embodied pedagogical framework which has an impact on the practice of education for democracy through associated guides to practice toolkits that support responsive participatory pedagogies test through participatory action research a prototype of the framework and guides in differing phases of education and national contexts refine the framework and guides disseminate and activate exploitation of the pedagogical framework and guides by trailblazer users the projects scientific impact will be achieved through groundbreaking transdisciplinary research that shows how aesthetic and embodied learning and responsive pedagogies for democracy facilitate new ways of seeing and exploring self and others enabling truly democratic relations and nurturing predispositions and capabilities for active democratic citizenship and deepening democracysocietal impact will be achieved through new pedagogical approaches that engage learners and educators hearts as well as minds increase capacity for democratic citizenship that connects and evolves locally and strengthen affective predispositions for challenging social injustices engaging with conflict and seeking mutual understanding
disability versus difference over development in the autisms

autism is an early developing condition diagnosed on the basis of difficulties in the domains of socialcommunication and restricted repetitive behaviors however the single label of autism masks a large degree of heterogeneity at multiple scales from genome to phenome and may not signal differential needs and services required for some types of profoundly affected individuals in order to better understand autism and develop more impactful ways to facilitate positive outcomes at an individualizedlevel we need better models that help to explain how autism may be differentiated in meaningful ways that help explain variability in developmental paths responses to treatment and differential underlying neurobiological mechanisms this research program develops and tests the autisms3d model disability versus difference over development as a firstlevel major distinction for explaining heterogeneity within the autism population autisms3d postulates that the major firstlevel split within the autism population is between subtypes described by profound disability versus difference in developmental outcomes stratification models using standardized clinical measures of intellectual functioning language and adaptive behavior will be used to predict disability versus difference subtypes these stratification models are based on highly reproducible datadriven clustering analyses from very large phenotypic datasets we will then test how the subtypes may develop differently with analyses of big clinical longitudinal datasets and also within the context of early intervention finally we will test the subtypes for neurobiological differences via neuroimaging mri fmri dti and electrophysiological eeg and gaze phenotypes eg eye tracking under static and naturalistic viewing conditions the research will help refine our understanding and concepts of autism and will be an important next step on the path to precision medicine for the autisms
ebiohub chair of research centre in biomedical engineering

the ambitious aim of the project is to establish ebiohub research centre in biomedical engineering within university politechnica of bucharest upb leaded by era chair holder the goal of the ebiohub project is to unlock and foster excellent research in biomedical engineering capitalizing the existing knowledge in upb and integrating with local research and clinical expertise from university of bucharest carol davila university of medicine and pharmacy and local hospitals as well as making use of the newly created research infrastructure inovabiomed by setting up a strong research group and attracting top academics in the field rising the competitiveness of upb research in the european research area era the developing of biomedical engineering a discipline that applies engineering principles of design and analysis to biological systems and biomedical technologies is in line with the romanian national strategy for rd the chair and the ebiohub centre will address the main barriers faced in upb such as lack of institutional organization in linking upb research teams with different expertise and linking the existing upb research teams with other local research institution lack of financing and practice not in line with open recruitment policy by establishing a chair holder with excellent research credentials and leadership competences by creating a research team with broad expertise and wide network for collaboration will greatly improve the research culture and research performance at upb sustainability will be granted by research funding procurement for projects structured cooperation with local or international industrial and public research and educational entities establishment of a new study field in the doctoral programs at upb phd summer school and other training programs by setting a best practice example and through a wellthought outreach campaign the project will stimulate structural changes throughout upb
how domain mimicry shapes genetic conflicts between hosts and viruses

viral mimicry is a prevalent evolutionary mechanism for the acquisition of hostprotein domains in order to hijack cellular pathways by leveraging the similarity between the original host and the mimicked domain the viral mimic forms interactions with host proteins this introduces genetic conflict since these interactions are advantageous for the virus and deleterious for the hostthe host is limited in its capacity to avoid mimics because evolving to escape them can disrupt the host interactome elucidating the way in which hosts evolve in the face of mimicry and the constraints placed on viral mimics are central to understanding the evolution of genetic conflictsto address these questions we will uniquely combine advanced structural modelling comparative interactomics evolutionary analyses and functional validations to map the functions interactions and constraints of viral mimics and their hostinteracting proteins specifically we will 1 map the landscape of mimicry occurrence in viral proteomes to find which domains are mimicked and which viral families tend to acquire such domains 2 characterize the cellular interactomes of both mimics and hostmimicked domains to identify shared targets between host and mimic and to find mimicspecific interactions pointing to neofunctionalization 3 study the sequence evolution of interface residues between mimics and their host targets and 4 characterize evolutionary mechanisms such as gene duplication that may be adaptive for the host or the virus using these novel techniques and integrative analyses we will unravel the factors shaping the evolution of mimics and their resulting genetic conflicts with the host these principles are important for understanding the evolution of mechanisms by which viruses acquire new functions and ultimately for predicting zoonotic potential and viral emergence
change toolkit for digital building permit

todays building permit issuance is mainly a manual documentbased process it therefore suffers from low accuracy low transparency and low efficiency this leads to delays and errors in planning design and construction several eu countries have developed attempts to push forward the digitalisation of building permit procedures but none of these have led to complete adoption of digital building permit processes within municipalities the aim of chek is to take away barriers for municipalities to adopt digital building permit processes by developing connecting and aligning scalable solutions for regulatory and policy context for open standards and interoperability geospatial and bim for closing knowledge gaps through education for renewed municipal processes and for technology deployment in order to reach trl 7 chek will do this by providing an innovative kit of both methodological and technical tools to digitise building permitting and automated compliance checks on building designs and renovations in european urban areas and regions the chek consortium consists of a multidisciplinary team covering gis bim municipal processes and planning data integration and standardisation in addition the consortium is a multisectoral mix of researcheducation aec and softwarecompanies governmental institutions and international standardisation organisations the multisectoral and multidisciplinary consortium is essential to align and connect all aspects of digital permit processes required to meet the highly ambitious project objectives several partners are already collaborating in the european network for digital building permit eunet4dbp the institutions in the advisory board representing governments and municipalities of other european countries will further assist the development exploitation and upscaling of results the best practices and developed software following the logic of openapi will enable replicability in any other european country
solar operational lifecycle and asset reliability intelligency system

in order to foster the development and integration of pv systems in europe and beyond more efficient reliable and profitable operation and maintenance om strategies need to be found in this context solaris will gather 15 partners 6 researchoriented partners 8 industrial partners including 2 startups 3 smes and a municipality for 48 months to develop and demonstrate a complete set of physical and digital tools for improved forecasting operational performance and maintenance resulting in high performance index 90 and availability 98 of pv plants and decreasing the levelised cost of energy by 10 solaris will provide operators with reliable forecasting short and longterm weather and power production accurate monitoring and inspection techniques through novel wind dust and impedance sensing as well as automated multispectral pv inspection using drones early fault detection incl preventive maintenance improved lifetime of strategic components through adapted responses selfprotection power electronics reconfiguration storage strategies and energy trading via an aibased tool demonstration data will be gathered in an iot platform feeding one of the main tools proposed to pv operators ie the pv asset management software all developments will be demonstrated and assessed in 8 usecases utility and smallscale groundmounted rooftop floating agripv across europe demonstration datasets and labelled data on the different usecases as well as longterm pv potentials for regions of demonstration will be shared publicly to foster developments of other initiatives the uptake of solaris developments will be enhanced by the wide dissemination of demonstration and assessment results to relevant stakeholders ie pv systems owners and om firms as well as technology providers it will be further facilitated by the creation of a stakeholder forum accompanying all developments towards commercialisation
merge media religion and gender transnational digital media actions of progressive and conservative social movements

the project explores how conservative and progressive catholicinspired social movements employ social media transnationally to discussgender it is original first in analyzing the heterogeneity of catholicism in supporting or opposing gender equality second in focusing on relevant social issues such as reproductive rights and lgbtq rights third in exploring social media use within transnational catholic activism often overlooked by existing literature the fellow will focus on two case studies 1 conservative catholic antigender movements that oppose lgbtq rights and feminism 2 progressive movements within the catholic church that advocate for the inclusion of women and lgbtq people the cases are based on the european and north american context hence the fellow will work in the following institutions for the outgoing phase the university of colorado us under the supervision of professor stewart hoover who leads a worldrenown center for the study of religion and media and is an expert in gender for the return phase the university of bologna italy under the supervision of professor alice mattoni who has expertise in transnational social movements and digital media research ethics and grant writing in the two institutions the fellow will acquire the skills to address these objectives 1 explore transnational social media narratives of catholic movements through big data analysis a skill acquired in training in both host institutions 2 compare the online discourses of progressive and conservative catholic groups through qualitative analysis helped by the supervisors expertise in software for textual analysis 3 research catholic actors online and offline strategies through interviews and participant observation a method honed during a secondment at the university of pittsburgh the project will produce results useful for the scientific and social understanding of social media use contemporary religion and gender equality
understanding nonlocality in quantum gravity

the formulation of a consistent theory of quantum gravity is one of the most outstanding unsolved problems in theoretical physics which has attracted interest since the middle of the last century in the past decades several promising approaches to quantum gravity have been proposed despite their intrinsic differences many of them seem to predict the emergence of nonlocality at the microscopic level ie at short distances and high energies indicating that the gravitational interaction is nonlocal in nature rather than pointlike this feature could be the key to solving open issues in gravitational physics such as classical curvature singularities and quantum divergences as nonlocality naturally introduces a physical cutoff scale nonlocal physics is expected to manifest through specific nonpolynomial form factors in the quantum gravitational lagrangian whose derivation however is still pending in all known approaches the aim of the proposed project is to derive and use fundamental consistency requirements of causality stability unitarity and healthy highenergy behaviour to constrain the viable form factors and thus the space of allowed quantum field theories of gravity the study will be modelindependent but its implications can severely limit the feasibility of various quantum gravity programs this project will take the field of nonlocal gravity beyond its current stateoftheart by deriving novel causality constraints constructing for the first time the hamiltonian for infinite derivative lagrangians and pioneering a complete oneloop computation of the quantum effective action the unique scenario to test new physics beyond general relativity provided by the new era of precision cosmology and gravitationalwave astronomy makes this project highly timely achieving the proposed goals can place nonlocal theories of gravity on firmer ground and lay the foundation for future phenomenological applications in cosmology and astrophysics
unravelling the intertwined correlated states of matter in moir superlattices

the recent observation of many quantum correlated phases including superconductivity and correlated insulating states in twisted bilayers of 2d materials has sparked tremendous interest and boosted intense research activity to understand these phases the ability of robustly engineering quantum states of matter with few tunable experimental knobs eg the twist angle between the two 2d materials represents a major breakthrough of these socalled moir materials which started the new field of twistronics in particular moir materials made from transition metal dichalcogenides tmds have gained significant momentum as a novel and robust platform for simulating quantum phases of matter on emergent 2d lattices while it is widely accepted that these quantum phases are driven by enhanced electronelectron interactions in moir materials the quantum nature of many correlated phases is still poorly understood theoretical and computational first principles methods can be extremely powerful in helping to unravel the experimental signatures of the different quantum phases and also predict new ones however standard methods like density functional theory are computationally too costly for moir systems for which typical unit cells contain thousands of atoms and generally unable to tackle the challenges posed by strongly correlated materials a new approach is therefore requiredin this fellowship i will develop an efficient multiscale framework involving different theoretical and computational methods for studying quantum phases of tmds moir superlattices specifically i will combine classical force field calculations machinelearning based tightbinding methods and manybody methods to overcome the limitations of conventional firstprinciples approaches while maintaining their predictive powerthis framework will allow us to shed light on the nature of the quantum phases hosted in moir materials which can be harnessed in future technologies
quantum optical physics with neutralatom waveguideqed

the coupling of cold atoms to nanophotonic devices has recently opened a variety of novel opportunities for controlling lightmatter interactions tailored dispersion relations offer unique features beyond conventional settings in particular photoniccrystal waveguides enable tight transverse confinement of the propagating light strong atomphoton coupling in single pass and tunable longrange atomatom interactions while this research area is extensively studied theoretically experimental progress has been much more modest this project aims at turning the emerging neutralatom waveguideqed paradigm into a mature fieldthe primary challenge will be to develop a versatile apparatus where ensembles of cold atoms can be trapped in the proximity of slowmode photoniccrystal waveguides using a specific material original structure designs and novel atomdelivery techniques the main project objectives are then threefold the demonstration of deterministic photonphoton interaction in a lossless singlepass configuration and its application to efficient quantum state engineering the realization of multiphotonstate engineering via atomic entangled states and subradiant and superradiant dynamics the exploration of a novel bandgap physics uniquely accessible with the developed photoniccrystal platform for strong atomatom and photonphoton interactionsthe successful realization of the project based upon the interdisciplinary interface of cold atoms and nanoscale waveguides could elevate this approach to a new route for strongly interacting photons and atoms with unique possibilities for integrated quantum technologies quantum nonlinear optics as well as for manybody quantum physics
neural correlates of narrative discourse in mild cognitive impairment

the goal of the proposal is to identify the association of different narrative perseverations features in mild cognitive impairment mci subtypes with their neural oscillatory profiles mci patients show moderately impaired performance on neuropsychological tests but relatively intact global cognition and daily functioning validated as different from both normal ageing and dementia mci is a risk factor for the development of dementia the evolving profile to dementia of mci subtypes is a largely debated issue mci patients typically show narrative perseverations in conversations ie reiterations of their own previous narrations according to literature perseverations have been studied as test responses in the context of dementia but have not been systematically explored as speech of mci patients recent studies suggest that different oscillatory responses can be observed in different mci subtypes however no effort has been attempted so far to relate such oscillation profiles to linguistic patterns in the speech production of mci patients the present action is therefore to investigate whether different narrative perseveration subtypes can be associated with distinct neural patterns oscillatory profiles