Dragon09/odtu_chatbot huggingface dataset:
giving voice to hispanic chant through a phylogenetic study of medieval plainchant

plainchant the sacred christian chant is the most ancient western corpus preserved in musical notation before the unifying adoption of the gregorian liturgy throughout europe in the 9th century a number of liturgical families each one with its own chant repertoire emerged in the ancient western roman provinces among them the hispanic liturgy was recorded text and music in manuscripts between ca 700 and ca 1300 these sources allow us to know the liturgys ceremonies and texts but not the melodies themselves in fact notational signs do not indicate the specific intervals between the notes since they were written prior to the use of a notational system in which each individual sign contains precise pitch information as a consequence the hispanic musical notation is considered indecipherable and its thousands of melodies still remain silentresound aims to achieve what has so far been considered an impossible task bringing to life the sounds of hispanic chant to accomplish this goal we will use tools from the fields of bioinformatics genetics computational analysis aural architecture and virtual restoration of sound and images along with tools from the humanities including musical performance computational analysis aside these tools have never been used in the study of medieval chant let alone in combination by recovering the sounds of hispanic chant and establishing these innovative methods we will be able to offer new understandings of the generative and evolutionary dynamics of the european plainchant repertoires in this way we will not only recuperate the hispanic melodies but also restore a significant part of the soundscape of medieval europe thus by reversing the standard approach via focusing on a territory considered peripheral we will shed new light on the process of cultural creation in the european middle ages
development of nanobodies against pseudomona aeruginosa and staphylococcus aureus and evaluation as immunotherapeutics

cystic fibrosis cf is a genetic disorder impacting various organs due to cftr gene mutations lungs are severely affected by secretions harboring bacteria causing recurrent chronic and often fatal infections in 90 of cf patients globally around 105000 people across 94 countries suffer from cf with an improved median survival age of 30 to 40 years yet poor quality of life persists due to daily treatment needs staphylococcus aureus sa and pseudomonas aeruginosa pa are the primary pathogens isolated from cf patients respiratory tracts leading to most cfrelated deaths their factors of virulence contributes to extensive damage and despite intensive treatments infections persist fostering antimicrobial resistance antibiotic resistance claims over 35000 lives yearly in the eu alone underscoring the urgent need for novel therapeutics to combat sa and pa infectionsnanobodies nbs offer revolutionary immunotherapy potential due to their unique attributes they are ten times smaller than conventional antibodies maintaining strong recognition capability at nanomolar levels nbs exhibit low immunogenicity rapid tissue penetration and can target previously inaccessible antigen sites their small size provides enhanced stability thermal resistance reversibility of unfolding proteolytic resistance and high solubilitygiven the prevalence and severe consequences of sa and pa infections the central aim of the project is to develop therapeutic nbs to mitigate the impact of these infections and improve the quality of life for cf patients
true demanddriven semiconductor supply chains for europe

sc4eu a collaborative innovation action aims at strengthening european digital sovereignty by mitigation of the chip shortage through reduction of bullwhip effect in the semiconductor industry and supply chains containing semiconductors this will be reached via a truerdemand signal gained from an anonymous mpc multiparty computation survey on coarse granularity which will be broken down via ai methods to fine granularities following the semantic web based digital reference structurethe bullwhip effect has led to a range of negative outcomes including excessive inventory inventory writeoffs decreased revenue workforce reduction and ultimately significant shortages as observed in the last covid years during the financial crisis in 0809 and during the com crisis in the zero yearsthe ambition of sc4eu consortium is to overcome these obstacles and to obtain highquality reliable data for semiconductor demand forecasting in the solution proposed by sc4eu data should be gathered via an anonymous survey based on multiparty computing technology anonymity and security of data flow will encourage business partners to share their true demand data then the gathered data will be mapped onto ontologies semantic representations of the semiconductor industry and processed with ai tools for demand breakdown of fine granularity
colonial recipes then and now

core colonial recipes then and now investigates how domestic colonial food cultures in the portuguese empire 14501600 reflect the mobility agency labour and knowledge of women and enslaved cooks and how colonial recipes can create space for more nuanced conversations around colonial heritage the project takes a global history approach to the empire examining the extent to which the mobility of people foods labour and knowledge between key port cities shaped colonial food cultures by focusing on domestic spaces it places women and enslaved cooks who did the labour of food preparation centre stage in this way the project revalorises domestic spaces as sites of global exchange which have been largely excluded from studies of global history as well as insisting on the importance of gender to understand the complexities of the relations between mobility food and empire by spotlighting colonial recipes core will spark new scholarly conversations about the insights these texts offer into subaltern mobility creativity and adaptability the intersecting production of gender race and class and colonial households as the centre of social provisioning and wider infrastructures of empire examining how new colonial cuisines intersect with colonial regimes of trade agricultural production and domestic slavery it makes three historiographical interventions namely it 1 responds to calls to write a global history of the early modern portuguese empire 2 brings the new imperial history further into dialogue with a history of the portuguese empire by showing how food illuminates colonial politics especially negotiations around gender race and class and 3 contributes to public debate around the production of heritage about the colonial past using colonial recipes to interrogate the multiple valences and contradictions of the empire and its legacies in the present
cbdc powered smart perforrmance contracts for efficiency sustainable inclusive energy use

the overall vision of fortesie is to design demonstrate validate and replicate innovative renovation packages in the building industry with smart performancebased guarantees and financing aiming at efficient sustainable and inclusive energy esie use to accelerate the renovation wave in europe the renovation packages will combine stateoftheart construction materials and technologies components prefabricated facades bipv heat pumps etc innovative digital technologies for measurement and verification and attractive financing eg contractual frameworks for smart performance guarantees financing mechanisms engagement techniques greeneuros etc to raise the overall epc value proposition the renovation packages will be tailored to specific target groups needs and optimised to improve the esie performance considering energy co2 and comfort each package will be demonstrated and validated in real life use cases and customised for replication in all other partner countries for immediate market takeup methodologies from social sciences and humanities ssh will be adopted for a the creation of collaborative business models that boost the renovation wave by considering all stakeholders value and revenue streams b novel incentivisation and behavioural change models that aim to stimulate long term engagement with focused interactions to adopt green behaviour c the incorporation of a digital currency greeneuro g for financing rewarding and creating an inclusive collective narrative in the fight against climate change d the collection of feedback for recommendations to policy and business stakeholders e mapping and understanding the complex interplay between the different stakeholders to deliver an engagement strategy across the value chainthese demonstrations will potentially constitute the greeneuro as a retail central bank digital currency cbdc hence revolutionising the financing of renovation approaches an online marketplace will be offering first level advice directing consumers through the value chain of stakeholders and facilitating access to these packaged renovation services
science for evidencebased and sustainable decisions about natural capital

the importance of biodiversity bd and healthy ecosystems and the services they deliver has increasingly been acknowledged policy initiatives such as the eu bd strategies 2020 and 2030 ipbes ipcc and cbd were launched to address bd natural capital and related values research has created a knowledge base to better understand naturehuman interactions that are at the base of ecosystem services es delivery the key aim of related actions is to provide robust information that can be harnessed to support protection restoration and sustainable as well as climateneutral use of ecosystems in the eu by 2030 maes has provided the conceptual methodological and data base for comprehensive assessments on different spatial scales including the euwide assessment 2020 and assessments in eu member states knowledge and data for different ecosystem types including protected and marine areas are increasingly available the next step is to integrate the different maes components ecosystem mapping condition es accounting and to enable the uptake of es in decision making key challenges include the proof of bdecosystem conditiones relationships and to link them to eu policies the consortium brings together experts from all eu member states associated countries and eu overseas regions with stakeholders from various public and private sectors the expertise in the consortium includes leading experts ecologists economists social scientists on es science ecosystem accounting and on sciencepolicybusiness interfaces from related actions openness esmeralda maia maes esp ipbes bd partnership therefore the project will successfully address the calls challenges and provide applicable tools and models together with guidance how to use them the project will deliver real cases for an evidence esbased and harmonised decision making across europe enabling transformative change to halt bd decline and to secure essential essustainable supply and use
nonwage attributes gender and the future of work

digital technologies the covid crisis rising incomes and changing work attitudes all contribute to the recent increase in the importance of certain nonmonetary aspects of work most prominently flexibility and work meaning what does this mean for gender differences on the labor market and for the future of work morethanmoney will integrate flexibility and work meaning into the theory and empirics of family labor supply and retirement choices in three subprojects i will develop models that combine behavioral labor and family economics collect unique data sets that combine administrative survey and experimental parts and use structural and reducedform estimation techniques a i will use models of collective labor supply and newly collected data to analyze the choice of hours worked flexibility and time spent with children at the familylevel choosing flexibility may reduce wages and decision power and thus affect the distribution of family resources a hidden cost of recent policies aimed at increasing flexibility may be that wages and bargaining power of women decrease b i will combine the labor economics flexibility with the behavioral meaning of work perspective and collect data on tradeoffs between meaning flexibility and wages consistently in several countries choosing occupations and sectors with high meaning like health and education may restrict the flexibility choice and force women to reduce their labor supply c i will take the longterm perspective while wages translate into retirement incomes nonwage attributes do not but they may cause an increase in labor supply i will model and collect data on tradeoffs between wages hours worked and nonwage attributes and estimate their effect on retirement decisions over the life cycle this will greatly increase our understanding of the large differences in retirement incomes between men and women
the trna epitranscriptome a novel player in viral infections

recent evidence indicates that codon usage bias regulates gene expression as synonymous codons are not decoded with the same efficiency viruses are entirely dependent on the host translation machinery to express their proteins puzzlingly the genomes of diverse viruses synthesize viral proteins at high levels such as those of the emerging chikungunya virus chikv dengue virus denv and the pandemic sarscov2 are enriched in rare codons that should slow down their translation how these viruses achieve this high protein expression remains a fundamental question in virology in juana dezs laboratory recent findings have revealed an unprecedented interplay of the chikungunya virus chikv with the host trna epitranscriptome chikv adapts the host translational machinery toward viral codon usage by overexpressing a trna modification enzyme that favors translating a specific set of codons enriched in chikv rnathe proposed project will combine cellular and molecular biology approaches with omics analyses to further develop this novel research area and explore its translatability first using sarscov2 as a model we will study whether the observed chikvinduced codonspecific reprogramming of the host translation machinery represents a common mechanism to optimize viral protein expression second we will characterize the trna modifying enzymes involved third we will explore the antiviral therapeutic interest of the identified enzymes together these findings will shed light on a novel layer of virushost interaction and might provide a rationale to consider the regulation of the host trna epitranscriptome as a promising target for the development of broadspectrum antivirals
twinning for excellence in biophysics of protein interactions and selfassembly

twin2pipsa will improve ri capacities of fcidulisboa portugal in the field of protein folding biophysics and conformational diseases by partnering in joint twinning activities with three worldleading research and technological development performers the university of cambridge ucam the university of copenhagen ucph and tel aviv university tau the folding and misfolding of proteins their interactions and selfassembly in cells is central to biology and has implications in diseases that affect millions of people worldwide the socalled conformational diseases include cataracts metabolic disorders and neurodegenerative pathologies such as alzheimers disease knowledge on the ability to modulate protein interactions and selfassembly is critical to develop applications of proteinbased biomaterials like bioadhesive glues or to design therapeutic antibody biologics twin2pipsa fulfils local needs and will generate outstanding contributions through investigations of pathological selfassembly in vitro and in living cells nanoscale characterization of proteinbased materials and implementation of integrative biomolecular simulations that will raise the international profile and scientific standing of fcidulisboa this will enable a local cluster of excellence whose scientific and technological breakthroughs will empower both project partners and the industry sector in their regional innovation ecosystems the partnership and network will significantly reinforce the ri capabilities of the widening institution and portugals innovation performance twin2pipsa comprises several twinning activities staff exchanges secondments to partners expert visits meetings training schools and a joint exploratory project that will translate into biomedical and biotechnological outcomes dedicated activities to reinforce research management capacities and administrative skills of fcidulisboa grant office through mentoring and staff exchanges are also planned
multipillar framework for children antiobesity behavior building on an eu biobank micro moments and mobile recommendation systems

during the last decades overweight obesity rates have reached epidemic proportions across eu prevalence in childhood is particularly alarming resulting in psychological impacts increased risks for ncds however although obesityrelated research has provided interesting results several issues arise due to the lack of metareviews the nature of data collected to address this biostreams aims on supporting the optimal use and reuse of health data eg biological demographic epigenetic etc to generate metadataknowledge and provide new evidences methodologies tools for a creating and deploying the biostreams biobank that will act as a scientific platform for research in obesity and better diagnostic and therapeutic approachesb understanding the transition from metabolically healthy to unhealthy preventing under age obesity c designing better strategies to educate empower young citizens for weight selfmanagement d coordinating authorities policy makers to develop crosssectoral solutions for health promotion under age obesity prevention specifically biostreams delivers a dedicated under age obesity biobank providing realworld health data including biospecimens anthropometrics behavioural and cost data from retrospective and prospective sources while taking into account efficient data harmonisation and standardisation principles transforming data valorisation towards under age obesity prevention and future research moreover the biostreams framework for data handling provides robust and transparent methodologies for operational procedures data infrastructures analysis and reporting via metareviews and aibased appscomponents evaluated via 12 multisite pilots 7 clinical and 5 schools citizen awareness and lifestyle alteration delivering obesity prevention guidelines knowledge generation while fostering considerable opportunities for regional and national health authoritiespolicymakers
housing precarity pathways meanings influences and responses among south asian migrants to dublin

housing affordability and homelessness have been persistent problems both for irish nationals and migrants over the last decade but these problems are particularly acute among the latter with the exception of those who are seeking asylum in ireland noneea migrants housing challenges have been largely ignored by policymakers in this country the housing situation of noneea migrants has also received little attention from researchers and the factors which shape their particular housing problems are not well understood in particular neither the interaction between housing precarity and other socioeconomic precarities which are more common among migrants eg relating to labour market discrimination or legal status has not been explored in depth nor have migrants responses to these challenges and their agency in trying to shape pathways through these precarities this research will fill these critical knowledge gaps by examining south asian migrants lived experiences of housing precarity in dublin irelands capital and largest city the project aims to investigate south asian migrants to dublin lived experience of precariousness in terms of housing labour market activity and immigration status and the interaction between these the project marries the concepts of housing precarity multiple precarities and structureagency integration to guide a groundbreaking multimethod anthropological study of these migrants precarity this innovative analytical framework goes well beyond the current stateoftheart and has the potential to illuminate the precarity pathways of other marginalised groups in ireland and internationally by employing mixed methods quantitative and qualitative this project will examine the interaction between housingrelated structures and migrants everyday agency and the role this plays in shaping their access to affordable and suitable homes and housing precarity
creating watersmart landscapes

with the growing human population the diffuse nutrient emissions from agriculture are expected to increase with the rise of fertilizer use this situation has created a need for sustainable intensification by increasing yields while simultaneously decreasing the environmental impacts naturebased solutions nbs such as wetlands and riparian buffer strips can efficiently reduce the nutrient runoff from agricultural catchments however most land and water management studies mostly do not identify specific priority areas where the nutrient runoff to the water bodies is the highest hotspots nor do they provide spatially explicit solutions to improve the environmental conditions identification of priority areas will be important for ensuring costeffective interventions to reduce the impact of intensive agriculturethe aim of the proposed project is to develop an analysis modelling and machine learning ml framework for finding spatially optimal land management scenarios for implementing nbs such as wetlands and riparian buffer strips to reduce agricultural nutrient runoff from catchments at different scales moreover the project will identify the landscape predictor variables at different spatial scales for nutrient concentrations and their crossscale interactions using mlwe will implement a novel discrete global grid system data cube to manage all environmental data needed for modelling we will take advantage of the strength and flexibility of existing ml methods to deal with complex ecosystem responses and to reveal new interactions among water quality predictor variables ml together with geospatial analysis will help us to develop different spatially explicit nbs allocation scenarios which we will evaluate with processbased hydrological modelling in addition we will address the challenges of processing large datasets by using proven parallelisation and distributed computing toolkits