Dragon09/odtu_chatbot huggingface dataset:
migration diaspora citizenship

the cofund fellowship programme migration diaspora citizenship is part of the strategy of the university of muenster wwu to further internationalise postdoctoral research and training in the social sciences and humanities and to strengthen their interdisciplinary and intersectoral dimensions in the context of the proposed mdc project the wwu pursues four primary aims first to enhance the academic and nonacademic career prospects of the fellows participating in this programme second to build a cadre of researcherpractitioners who are able to communicate work and cooperate across national sectoral and disciplinary boundaries third to share best practices within a large and growing international network of academic and nonacademic partner organisations last but not least the fourth longterm aim of this project is to effect sustainable change in academic structures and human resource development by contributing to the creation of a new academic culture that fully supports and rewards interdisciplinary and intersectoral research with its focus on the social sciences and humanities this programme targets fields where interdisciplinary and intersectoral training and research are still relatively uncommon and underdeveloped particularly in comparison to the natural and life sciences in tackling these deficits the wwu will rely on existing training programmes academic networks and its longterm experience with highprofile research projects in the respective fields by centring the programme around the ubiquitous and interconnected phenomena of migration diaspora and citizenship the mdc project builds upon established research excellence among its partners and opens up research opportunities for scholars with a wide range of academic interests and backgrounds while also facilitating highquality interdisciplinary and intersectoral collaboration among the fellows and partner organisations which is key to accomplishing the abovementioned aims
isolating the first arctic giant viruses and their bioactive compounds arcgirus

giant viruses gvs comprise a ubiquitous and unique viral group their large genomes encode a majority of proteins with unknown functions an important but overlooked source for new biotechnological breakthroughs most known gvs have been isolated in hosts from the genus acanthamoeba and none has yet been found from the arctic one of the most important ecosystems in the world this came as a surprise considering various metagenomic studies revealed the presence of gvs worldwide especially in marine ecosystems more studies on hostgvs interaction also bring forth their potential for viralderived bioactive compounds hence this project arcgirus aims to innovate in giant virus research by o1 isolating the first algalinfecting giant virus from the arctic this will overcome the acanthamoebafocused host bias and at the same time explore an important but never studied environment in this field then i will o2 characterize the isolates and o3 develop a novel method using mass spectrometry to find potential bioproducts at the phenotypic level from cells infected with giant viruses the biological data obtained through this project will have an impact on virology and evolutionary biology likely leading to interesting basic research projects and applied science advances in addition to increased awareness of the arctic virosphere and nature in general the gvs isolates and publications generated through this project will become important references in the field and open the possibility of collaboration the use of social media and collaboration with museums will advertise the study of gvs and raise awareness of their role in the marine microbiome to general audiences overall the novelty of finding giant viruses infecting microalgae from the arctic together with the training and knowledge acquired from this fellowship will support my career goal of becoming a leading polar microbiologist specializing in giant viruses
cellspecific functional connectivity of cerebellar outputs for locomotor learning

everyday behaviours like mastering dance moves or hiking through uneven terrains require motor learning although essential cellular and circuit mechanisms for this type of learning are poorly understoodin the context of locomotion learning can be induced on a splitbelt treadmill where each side of the body moves at different speeds this is currently used as a rehabilitative therapy in patients presenting asymmetric gaits following brain damage the receiving laboratory recently showed that mouse locomotor learning is remarkably similar to humans regaining gait symmetry is achieved through specific adjustments in interlimb coordination moreover the laboratory demonstrated that this form of motor learning depends critically on intermediate cerebellum strikingly spatial and temporal components of learning ie where and when paws land proceeded independently suggesting that they might be dissociable at the neural circuit level however how cerebellar outputs act to calibrate spatiotemporal coordination between limbs is unknownip2adapt aims to decipher the functional connectivity of cerebellar output circuits conveying corrective calibration signals to modify locomotor movements in space and time specifically we will 1 use advanced viral tools to map output circuits downstream of the cerebellum and identify candidates for spatial and temporal calibration signals 2 use highresolution quantitative behavioural analysis and cuttingedge circuit manipulation to test specific functional roles of projectiondefined subsets of cerebellar outputs in locomotor learning 3 use stateoftheart recordings of these functionallydefined neurons during learning to understand how the cerebellum transforms locomotor errors into spatial and temporal calibration of limb movement this work will reveal unprecedented insights into neural circuits that ensure the adaptability of motor commands with direct relevance for rehabilitative therapy
airborne wind energy innovative km2 awe system by kitemill

the energy sector is the most polluting industry in the world accounting for more than of total greenhouse gas ghg emissions globally thus the net zero target is unachievable without major transformations in the global energy sector drastically increasing the share of renewables in the total energy mix including wind energy kitemill is a global leading airborne wind energy awe technology developer founded in 2008 based in norway currently we are developing our first commercial system km2 100 kw an emerging renewable energy technology km2 consists of a kite connected with a tether to a ground station the system offers the following advantages compared to conventional wind i significantly lower capex and opex ii 90 less raw materials and 90 less critical raw materials used iii 50 lower lcoe iv more stable output v simplified installation and maintenance process vi most costefficient energy production technology over a large part of the global land area vii reduced co2 footprint viii enable a wider range of areas suitable for wind energy ix greater social acceptance hence easier to secure permitsby advancing awe technology kitemill aims to reduce co2 emissions enhance energy security and promote sustainable green industrialization in the eu and globally this eic project will directly contribute to implementing the european green deal and is aligned with the net zero industry act nzia km technology promises substantial societal economic environmental and climate benefits as it aims to deliver clean and affordable energy especially in rapidly growing economies addresses urgent global challenges contributing to the un sustainable development goals sdgs eic funding will derisk the km2 system as it will allow us to complete the riskiest development steps and demonstrate the systems performance in an operational environment unlocking additional private capital and boosting customer and public trust
friction stir welding of innovative high strength aluminium alloys

as the worlds second most widely used metal after iron aluminium al and its alloys play a crucial role in decarbonizing the transportation sector and achieving climate neutrality for both the eu and our world essentially alalloys reinforced with quasicrystalline qc phases have the potential to be used as the main structural material in evehicles due to their strength lightness corrosion resistance recyclability and formability however during the joining process of larger parts the realised temperature may affect the microstructure and mechanical properties due to the strong flow of the material and the transformation of intermetallic phases in this project the process parameters of friction stir welding will be defined to obtain highquality joints the joints will be developed using an interdisciplinary approach combining reliable microbeam analysis technique electron backscatter diffraction product and process engineering to determine optimal process parameters as well as tool design and management to obtain process automation the collaboration between the academic centre for materials and nanotechnology acmin of agh university of krakow and nonacademic partner iskra isd will provide the researcher with the highest possible skills and competencies that will contribute to eu competitiveness and growth in the field of novel alloys reinforced with qc working closely with industrial partner iskra isd the developed technology will be carefully validated completion of the project will represent a major step forward in the applicability of novel alalloys and contribute to a significant reduction in resource consumption and ghg emissions
towards a deep knowledge of the extracellular matrix proteins functions in the duchenne muscular dystrophy

healthy skeletal muscle has a powerful capacity to regenerate after an injury on the opposite muscular dystrophies mds are devastating diseases where these regenerative capacities are overwhelmed and the muscle fibers are progressively replaced by fibrosis leading to muscle loss and finally to death fibrosis is the final outcome of excessive production of molecules constituting the extracellular matrix ecm however ecm alterations in mds have been considered only as the result of muscle damage the inflammatory response or an unbalanced degradationsynthesis by fibroblasts myomatrix is a 2year project proposing a innovative point of view by shifting the focus to the extracellular environment ie ecm as an active partner impacting on muscle cell properties the final goal is to decipher the role of ecm in skeletal muscle homeostasis and to define the molecular ecm components at work during mds specific objectives include the combination of proteomics transcriptomics in situ 3d tissue analyses and exvivo functional cell experiments comparison of muscles in various conditions normal regenerating and dystrophic will define key molecular determinants controlling beneficial ecm remodeling in healthy regenerating muscle versus detrimental fibrosis in dystrophic muscle the transdisciplinary biochemistry and biology and multilevel protein mrna cell tissue approach will identify new components in mds such an outsidein approach has never been tested so far in skeletal muscle the project implemented by a biochemist researcher in a biology host lab universit claude bernard lyon 1 at institut neuromyogne will identify the molecular alterations of ecm in mds and how they affect the behavior of cells that contribute to muscle homeostasis the identification of the ecm molecular determinants is the ambition of the project to propose therapeutic targets for md patients for whom an effective treatment does not exist yet
halide solid state batteries for electric vehicles and aircrafts

to support the upcoming shortterm needs of the battery industry it is imperative to have new differentiating european battery technology for 4b generation batteries on the market from 2025 halide solid state batteries for electric vehicles and aircrafts helena responds to the need of the development of a safe novel high energy efficiency and power density solid state battery 4b generation batteries cells based on high capacity nirich cathode nmc highenergy li metal lim anode and liion superionic halide solid electrolyte for application in electric vehicles and especially in aircrafts helena will support europe in this sense on its transition towards a climateneutral continent since electric aviation is poised to take off within the next five to 10 years with innovations already being pursued for electric vehicle batteries moreover helena will avoid dependence on asia for battery production helena is built by a multidisciplinary and highly research experienced consortium that covers the whole battery value chain and proposes a disruptive halidebased solidstate cell technology with the overall aim to significantly increase the adoption of these batteries on aircrafts and evs the technical challenges that are presented by current conventional battery technology and the consumer needs will be overcome especially the reduction in costs of battery devices enable scalable and safe cell manufacturing increasing their capabilities for long distance traveling and fast charging ensuring a high safety of the battery
icevoltaics from the workmanreynolds freezing potentials to electrical energy

water and aqueous solutions release a huge amount of thermal energy during freezing accessing energy utilizing the freezing process has never been attempted until today it is known that orderly freezing of dilute aqueous solutions can result in electrical potentials as great as 230 volts at the icesolution interface namely the workmanreynolds freezing potential wrfp and a maximal electrical current of 1 a based on our newly published results of counter ion separation during icing growth in ionic liquids this project aims to combine highthroughput computing and nanotechnology for probing the approach of controlling and utilizing stable wrfps and for the first time to enable energy exploration in the freezing process of aqueous solutions specifically ionic liquids will be screened for maximizing wrfp and electrical energy output via atomistic modeling and multiscale experiments critical parameters for wrfp including ion concentration temperature and freezing rate will be investigated for their effects in electrical energy generation novel electrical energy output based on wrfp will be constructed and tested which will seed an entirely new green energy acquisition research and application field the project termed icevoltaics explores an untouched energy source and provides highly innovative solutions of the future and clean energy
pioneering diagnostics in dermatology and cancer

at dermagnostix we envision the next level for molecular diagnostics in human skin to improve patients lives and clinical practice in dermatologyskin diseases are the 4th most relevant human illnesses according to loss of quality of life conventional diagnostics in dermatology based on clinical view and histopathology are imprecise and subjective resulting in up to 50 of misdiagnosed cases and insufficient or harmful therapies at dermagnostix we have developed a comprehensive technological platform for fast and objective molecular diagnostics in dermatology to reduce health care costs and improve patient treatment our fully automated platform delivers results within 90 min and testing can be run everywhere and at any time our easytohandle diagnostic device brings objective and precise skin diagnostics to reality allowing simultaneous detection of up to 40 different molecular targets within one single test
rna and cell biology from fundamental research to therapies

polish science including biomedical research has made huge advances in the last 30 years however the advancement of its fundamental scientific discoveries toward medical or commercial applications still lags behind the top countries worldwide this gap stems from the limited experience of polish researchers in the field of translational research the international institute of molecular and cell biology in warsaw iimcb aims to close this gap by building the capacity to translate basic knowledge into clinical innovations and by introducing an entrepreneurship culture in the scientific environment in poland since its creation the iimcb has been a lighthouse of research and management excellence in poland recognising the institutes achievements and future potential the polish government awarded funding to build an expanded modern iimcb headquarters which will increase our capacity up to 20 research groups the race project under the teaming programme will help us achieve this reality and successfully upgrade the iimcb to a worldclass translational research centre of excellence in rna and cell biology together with our advanced partners the medical research council human genetics unit of the university of edinburgh uoemrc hgu and vib in belgium we have identified five specific objectives that are key to achieve our goal namely recruitment and training of the next generation of entrepreneurial group leaders and researchers objectives 1 2 establishment of modern and selfsustaining core facilities adapted to commercial use objective 3 implementation of systemic technology transfer objectives 4 and administrative support objective 5 ultimately the race project will make the iimcb a reference model in translational research countrywide and elevate the institute to the top tier of european research centres ready to engage in competitive eu and global biomedical research and innovation projects at the frontiers of science
homology of labelled configuration spaces via spectral lie algebra methods

the goal of this project is to produce new computations of the mod p homology of labelled configuration spaces of a general manifold with labels in an arbitray spectrum these computations have remained outstanding challenges for decades except in special cases recently developed techniques in stable homotopy theory including spectral lie algebras and synthetic homotopy theory have proven to be useful in understanding the algebraic structure on the homology groups of labelled configuration spaces in universal cases but are less attuned to the topology of the input manifolds in this project i plan to attack the problem by incorporating the homotopytheoretic methods with approaches that take into account the geometry of labelled configuration spaces new computations of these objects will have applications in a range of fields including stable homotopy theory string topology embedding calculus of manifolds mathematical physics and motion planning the supervisor will be prof nathalie wahl at the department of mathematics of the university of copenhagen
detailed cortical mechanisms of topdown visual processing

what we see depends on what we have in mind for example we can quickly find tomatoes in the vegetable department of a supermarket by searching for red and round objects making them stand out from the background this is thought to be supported by topdown processing within the hierarchy of areas in the visual cortex but the detailed neural mechanisms are still poorly understood partly because of limitations in neural recording technologies in my lab we recently developed a threephoton microscope capable of visualizing the activity of large populations of individuallydefined neurons in awake and behaving macaque monkeys combining this novel imaging modality with wellcontrolled behavioral tasks provides the exciting opportunity to investigate the neural mechanisms of generative vision at an unprecedented scale and level of detail we will train macaque monkeys to search for shapes hidden in noisy texture elements investigate the strategy used by the prefrontal cortex to encode the mental template to guide this search and how this process warps the encoding of visual information in nearly complete local populations of neurons in early visual areas we will investigate the topographic organization of the recorded population of neurons and develop viral and histological tools to determine their cell types as well as their connectivity profiles we will also use psychophysics to make a link to conscious perception in humans investigating how a search template can warp perception finally we will incorporate our empirical findings into artificial neural network models with interpretable circuit mechanisms this is expected to bring the flexibility and robustness of generative vision into models of artificial intelligence as well as provide a computational framework to define novel hypotheses about the detailed neural mechanisms of generative vision in primates which we can subsequently test with both behavioral measures and invivo recordings
stratified therapeutic assessment platform for short telomere related lung fibrosis using patientderived ipsc

idiopathic pulmonary fibrosis ipf is a lethal scarring lung disease often leading to death within 3 years of diagnosis new antifibrotic medications slow disease progression but they are poorly tolerated by patients telomeres protective structures or caps at the ends of chromosomes governed by the enzyme telomerase are shortened in type 2 alveolar epithelial cells at2s in sporadic ipf but particularly so in inherited mutations of telomere related genes causing severe disease with early onset early clinical studies indicate that danazol modulates telomere length and prevents the progression of pulmonary fibrosis but it is poorly tolerated by patients causing liver toxicity gene therapies including mrnas which target telomerase have potential but human preclinical models do not exist to test their efficacy thus a new human preclinical model is required to better understand pathogenesis and find new treatments in preliminary work i demonstrate that at2 cells generated from patientipsc iat2 can replicate elements of pulmonary fibrosis pathogenesis and that telomere length in these cells undergoes heterogenous shortening over time analogous to the shortening which occurs in vivo based on this data and previously published mouse studies i hypothesise that telomere shortening in at2 cells causes senescence dna damage and inflammation in both sporadic and inherited forms of ipf furthermore i hypothesise that specific gene stratified mrnananomedicines delivered to the lung can modulate telomere length in a precise manner avoiding toxicity i will compare iat2 and hepatic cells generated from patients recruited to a clinical trial of danazol to their own clinical outcomes from the study thereby performing the first clinical trial in a dish in pulmonary fibrosis to a better understand the role of telomere shortening in ipf and to b identify and test gene stratified mrnananomedicines and delivery chemistries leading to improved patient survival