Dragon09/odtu_chatbot huggingface dataset:
bone brain breast and axillary medical microwave imaging twinning

medical microwave imaging mmwi is an alternative type of medical imaging which has shown promising results in a handful medical applications for the past 20 years the applications addressed in this twinning project are bone brain breast axillary region 3batwin diagnosis mmwi is an attractive imaging modality due to its noninvasiveness use of nonionising radiation no need for compression low power and comparatively lowcost when comparing to other imaging modalities all these characteristics make mmwi an attractive imaging modality for screening of several diseases or conditionsin this twinning project the main goal for the partners is to ultimately capacitate the coordinator with the various specificfine knowledge and tools which will allow to accelerate mmwi from the research bench to the patient bedside researchers in fcidciencias possess general knowledge within the mmwi field of research that allowed them to attain their current standing however their journey to establish a laboratory and reach their current position has been a lengthy processthe overarching objective of 3batwin is for fcidciencias to gain excellence capacity in all subfields related to mmwi research and become strong competitors in translating their unique breast and axillary region device to the hospital which will be possible by further establishing a solid collaboration with project partners university of galway galway in ireland and politecnico di torino polito in italy galway and polito are two excellent research institutes also working on mmwi projects with excellent knowledge in specific fields that are of interest to raise the profile of fcidciencias by leading 3batwin gaining key knowledge and working alongside the excellent project partners fcidciencias will be well poised to achieve excellency boost their research and innovation capacity and become a competitive national and international reference in the area of medical microwave imaging
physical basis of collective mechanotransduction bridging cell decisionmaking to multicellular selforganisation

there is growing evidence that mechanical forces emanating from the tissue microenvironment can activate biochemical signalling to control gene expression in a process known as mechanotransduction for tissue regeneration and organ development importantly disruption of this effect by changes in the microenvironment leads to pathological responses including tissue fibrosis and cancerthe advent of new force measurement techniques and highresolution microscopy have made it possible to isolate impacts of mechanics from genetic and chemical factors giving unprecedented access to investigate fundamental questions on how mechanical cues at the tissue scale affect signalling at a single cell levelthe proposed research aims to reveal the physics of mechanotransduction in the context of multicellular aggregates focusing on the impact of mechanical forces from multicellular motion and the mechanical feedback from the activation of biochemical signalling my central hypotheses are i localisation of mechanical stresses by the cell environment instructs transcriptional activation to direct multicellular behaviour and ii the gradients of mechanical forces in a growing multicellular aggregate can act as guidance cues for the morphology of growing tissuei combine experiments on breast cancer cells of varying degrees of aggressiveness with multiscale modelling discrete and continuum simulations to explain the interconnection of transcriptional activation and multicellular motion this will fill the gap between biochemistry at the cell level and mechanics at the tissue level and is essential to the understanding of physical mechanisms that lead to healthy behaviour or malfunctioning of tissue as well as to finding proper therapies for diseases that emerge at tissue scales moreover in a field dominated by genetic and chemical understandings the outcomes of this project will provide a fresh view based on the biophysics of force transmission across the tissue
2d sandwiches artificial layered building blocks for multifunctional materials

the possibility to create new materials bottomup was enhanced via the stacking of atomically thin layers of twodimensional 2d materials with van der waals interactions vdwis unfortunately the downside of vdwis is the in general weak electronical and mechanical interaction between the individual layers this hinders the creation of multiferroic materials working at ambient conditions which are despite extensive research still very scarce from stacked layers with vdwisthis research aims to create a new 2d building block the 2d sandwich this is a layered heterostructure with a strong interaction between the sandwichs individual layers mediated via an ionic or multivalent bond whereas the interaction with other layers is still solely due to the vdwis as the prototype functional material a 2d magnetoelectric multiferroic sandwich composed of layered transition metal chalcogenides oxides or iodides will be grown using the modulated elemental reactants method to tackle the possible sample degradation in the sandwiches ultrahigh vacuum optical surface science spectromicroscopy techniques will be developed to optically probe the 2d multiferroic sandwiches for both magnetism ferroelectricity and the coupling between them the concept of open samples will be introduced facilitating the scientific community with the straightforward verification of the data and accelerate the development of this new class of 2d sandwichesthis project will provide material design strategies that can remove the stringent lattice matching criteria to stack different classes of layered materials and provide these class of layered materials with similar stacking freedom as layered materials with vdwis these insights will allow the interbreeding of different classes of layered quantum materials such as complex oxides 2d layered crystals with vdwis cuprate superconductors or topological insulators or semimetals
enabling the whoroadmap 2030

we will establish for the first time in ntds an adaptive clinical trial platform and improve clinical research infrastructure in four ssa countries a drug acting safely on multiple helminths species would be a major leap to tackle ntds and enable the who roadmap ewhorm the cheap and freelyaccessible pannematode drug oxfendazole oxf has such potential given the limited portfolio of anthelmintic drug candidates ewhorm will assess its efficacy in an adaptive clinical trial for simultaneous evaluation against onchocerciasis loiasis mansonellosis and trichuriasis thus not only the largest group of ntds but also diseases that are not yet listed will be adressed this design significantly reduces patient numbers development timeframes and enables treatment of coinfections combined with our highly sensitive molecular tests we provide a patientcentric approach providing tools for targeted treatment test and treat and precision mapping for elimination programs strengthening of early career scientists in ssa in all aspects of clinical trial conduct and research including data management simulation and statistical analysis will be fostered by introducing a master and phd program a mentorship program as well as several webinars an opensource virtual training and assessment tool for diagnosis of ntds will complement the knowledge transfer to remote areas in ssa the consortium encompasses an interdisciplinary partnership from eight different countries germany the netherlands austria switzerland cameroon gabon tanzania and drc each group brings unique knowhow and recognized complementary experience to the project to ensure sustainable capacity building within ssa countries through joint development of and training in modern regulatory clinical trial conduct adaptive clinical trial design and stateoftheart diagnostics we will strengthen ssa researchers and clinicians to respond to persisting and future health challenges
time allocation of men and women in india the role of bargaining power

time allocation among household members across various paid and unpaid activities throughout the day gets negotiated through individual preferences gender norms and the bargaining power of respective individuals the time allocation across activities by gender age and location is associated with sustainable development goal 5 on gender equality indicator 541 and the differences in time allocation by gender are linked to the process of economic development of a country despite the societal and economic significance scholarly discourse on time use is until now mainly restricted to developed countries with a lack of data hampering the analysis of intrahousehold time allocations in developingcountry contexts in this project i will use time use survey 199899 and 2019 data from india together with the national family health survey ii 199899 and v 201921 data from india to examine the intrahousehold allocation of time across paid and unpaid activities i will use econometric specifications to examine the variation in paid work unpaid work domestic work care other unpaid work leisure and necessary activities by considering the intersectionality of gender with socioeconomic identities location and their change over 199899 and 2019 in addition i will explore how various measures of married womens power womens education level relative to their husbands and mothersinlaw their decisionmaking autonomy and freedom of movement outside the house influence intrahousehold time allocations across activities this project moves beyond the narrative of power previously explored in developed countries and examines the forms of power that influences womens time allocations in a developingcountry context the approach of this project is likely to be relevant for other countries that are governed by similar gender norms and the findings will add to the evidence base for monitoring the global progress toward sdg 5 and specifically for india
engineered viscoelasticity in regenerative microenvironments

tissues are viscoelastic materials whose mechanical properties evolve with time and yet this important property has not been incorporated in the design of regenerative biomaterials mechanical properties of biomaterials are known to influence fundamental cellular process including cell migration cell growth and cell differentiation however most of the work to understand the mechanical properties of substrates on mesenchymal stem cell msc differentiation has made use of pure elastic materials cells probe their environment by pulling forces and receiving mechanical feedback through membrane receptors since viscoelastic materials respond with a time dependent process to force we hypothesise that viscoelasticity will play a fundamental role in the differentiation of mesenchymal stem cells and hence in the design of regenerative biomaterials this project will develop a a new family of viscoelastic hydrogels with controlled properties that include biochemical functionalities recapitulating the properties of the extracellular matrix in vivo extreme mechanical properties ie very lowhigh elastic and viscous properties and mechanical gradients and b brillouin microscopy to follow the evolution of the local viscoelastic properties of these cellladen materials as a function of time we will use viscoelastic materials to promote bone regeneration in vivo using our criticalsized defect in the mouse radius model and in a major attempt to move the field forward we will further develop brillouin microscopy to monitor the viscoelastic properties of regenerative microenvironments in vivo
scientificbased exposure and risk assessment of radiofrequency and mmwave systems from children to elderly 5g and beyond

the pervasiveness and socialeconomic dependence on wireless technology has steadily increased over the last three decades currently the 5th generation 5g new radio nr cellular system is being deployed to unlock the potential of new applications that require the connection of many more devices internet of things higher data rates and low latency autonomous driving factory of the future 5g operates in two frequency bands 5g nr fr1 and 5g nr fr2 many exposure parameters of 5g are similar to those of 2g4g however there are also many differences that lead to major knowledge gaps all of which will be addressed by the seawave project seawave will i quantify the differences in exposure patterns between 2g4g and 5g for the entire population including children ii provide new tools and instruments for reliable exposure evaluation of base stations local networks in factories and enduser devices iii provide the means to minimise exposure iv generate important new scientific data for assessing the health risk from exposure to the new frequency bands fr2 especially with regard to the potential cocarcinogenicity of skin exposure and other hazardous effects and v provide knowledge for effective health risk communication and dissemination to various stakeholders to achieve these ambitious objectives the interdisciplinary consortium consists of highly experienced partners with leading expertise in the field who ideally complement each other to achieve maximum impact european citizens workers national public health authorities european commission services regulators and standardisation bodies will all benefit from the seawave results as they will support sciencebased decisions and policies for the safe deployment and use of 5g and future wireless networks project seawave is part of the european cluster on emfs and health
deep optimized generation for antimicrobial peptide discovery

the dogamp project will develop cuttingedge methods for deep optimized generation dog and use them to transform the emerging field of antimicrobial peptide amp discoverycontinuous overuse of antibiotics fuels the outgrowth and spread of multidrug resistant microbial strains increasing antimicrobial resistance is already now a major health and economic hazard and is expected to account for 10 million deaths globally per year by 2050 exceeding deaths caused by canceramps are short peptides that can actively and selectively kill antibioticresistant pathogens and as such are considered the most promising strategy for fighting antimicrobial resistance still intensive research on amp did not translate to their success in the clinic mostly due to their lower activity and safety compared to existing antibiotics deep optimized generation has the potential to radically advance amp discovery but only once unsolved problems are attacked and open research directions in this area are further explored to reach three major objectives of the dogamp projecti develop a novel model geared for deep optimized generation combining the variational autoencoder framework with probabilistic modeling and algorithms for pareto conflicting multitarget optimization dealing with data scarcity and bias generation diversity and model interpretabilityii combine the deep optimized generation model into a framework tailored for the specific needs of amp design eg accounting for amp clustering or conflicting features that make amps active or toxiciii apply the newly developed framework to explore and navigate the space of peptides to select and experimentally validate the best candidates that will supersede existing amps and antibiotics in their activity against hazardous microbes and safetydogamp has the potential to bring breakthroughs in the broad research areas of deep generative modeling sequence optimization and amp discovery
multisite phosphorylation in biomolecular condensates

biomolecular condensates are membraneless organelles that serve as specialized phaseseparated microenvironments within which many cellular processes can occur efficiently and with precise spatial and temporal organization as such condensates are an important target for scientific research because they can be used as regulatory mechanisms to turn cellular processes on or off condensates comprise flexible multivalent biomolecules with multiple binding sites this allows them to interact with various molecules simultaneously enabling biomolecular clustering that can lead to phase separation kinase phosphorylation is a critical mechanism that triggers formation and dissolution of condensates once formed condensates display emergent properties which arise due to the collective behavior of their component biomolecules i propose to investigate the mechanism of consecutive catalysis by kinases within condensates and how the properties of condensates affect kinase activity i will use synthetic condensates containing a minimal model kinase substrate that strongly partitions protein kinase a to examine kinase reaction kinetics in vitro and in vivo the experiments described within will elucidate whether kinase catalysis proceeds distributively or processively within condensates the proposed research will identify the fundamental principles of kinasedependent condensate regulation particularly the impact of multisite phosphorylation on the regulatory dynamics controlling condensates since condenstates and kinases form a mutually responsive system regulating many basic aspects of cellular physiology understanding how they interact will provide greater knowledge of disease mechanisms by unraveling the intricacies of these molecular interactions i will uncover novel insights into cellular regulation that can be used to develop innovative therapeutic strategies to address current challenges in health and disease such as cancer and neurodegenerative disorders
automated endtoend data life cycle management for fair data integration processing and reuse

the ability to integrate data from multiple sources is nowadays a major competitive advantage for organizations datadriven applications using ai techniques are reshaping various industries such as manufacturing tourism and mobility the european strategy for data aims to create a single market for data while ensuring europes global competitiveness and data sovereignty this has led to the development of common european data spaces yet the governance of the data life cycle in organizations has not kept up with the rapid technology evolution and remains largely manual this is especially evident in scenarios where tens or hundreds of continuously evolving data sources produce semistructured data and create significant challenges when governed manually causing organizations to end up with data silos a systematic and standardized mechanism is needed to ingest integrate and process data thus boosting the ability to develop new datacentric business models however current research and development efforts typically target one aspect of the endtoend data lifecycle such as scalable data management ml performance ai explainability or sharing while dismissing its governance to overcome this limitation cyclops proposes a new framework for the governance and maintenance of the complete data lifecycle for largescale volumes of data generated in heterogeneous distributed sources to enable data sharing and exchange cyclops intelligently automates by means of knowledge graphs kgs and with a humanintheloop approach the generation and execution of data processing pipelines kgs are the established formal models to represent data and metadata while providing context and guaranteeing interoperability with other systems adhering to the fair guiding principles cyclops will enable organizations to seamlessly provide cross and analyze machine and humangenerated data from and for data spaces thus facilitating the provision of addedvalue services on top
gender equality in rural and agricultural innovation systems

grass ceiling will develop a context where women can drive socioecological transitions that is develop innovations in response to socioecological challenges and strengthen the resilience of rural areas this is essential to deliver the uns goals on gender parity realise the eu gender equality strategy and achieve the goals of the green deal the farm to fork strategy the longterm vision for rural areas and the european pillar of social rights grass ceiling is a multiactor project that will increase womenled socioecological innovations in farming the rural economy and in rural communities ie smartagri skills ecotourism pasture led agriculture organic cheese energy neutral village halls community gardens elderly care cooperatives socioecological innovation in farming and rural areas is a developing area in europe and grass ceiling will cocreate tools to ensure women can fully participate our consortia include endusers women innovators stakeholders and researchers in case study member states as well as european bodies and stakeholders who can influence eu policy such as the eu womens entrepreneurship platform wep copacogeca eu representatives of farmers and agricooperatives the european association for information on local development aeidl and the european environmental bureau eeb grass ceiling brings together leading academic partners with many years of experience in research and practice projects that seek to empower and support women in agriculture and rural areas throughout a variety of contexts in europe the project involves womeninnovators on farms and in rural areas who will participate in our 9 socioecological women innovator living labs in 9 case study countries our living labs are practical womenled interactive innovation initiatives that will increase knowledge and provide tools to assist women innovators and policy and support organisations at member state and eu level
clinical development of rift valley fever vaccines in endemic regions

initial funding was provided to the coalition for epidemic preparedness innovations cepi in 2019 which was used to support preclinical and clinical development of rift valley fever rvf and chikungunya chik vaccines respectively this funding was provided to applicants as a joint effort between cepi and the horizon 2020 programme under the cepi call for proposals cfp3i whilst previous funding has led to the development of prelicensure chik vaccines development of rvf vaccines is at a much earlier stage hence this current application seeks to leverage a further 35m from horizon europe which will be supplemented with 15m from cepi making a pool of 50m which will be used to fund clinical development of rvf vaccine projects under the cepi followup call for proposals cfp3iiit is envisaged that applicants for the cfp3ii funding will have already developed a manufacturing plan and that all preclinical studies have been completed with the possible exception of development and reproductive toxicology dart studies applicants will propose phase iii trials in endemic regions for vaccines which are in accordance with the who target product profile httpswwwwhointdocsdefaultsourceblueprintcallforcommentstppriftvalleyfevervaccinesdraft30pcpdfsfvrsnf2f3b3142 for rvf vaccinesawards will usually have a 36month duration and will be administered by the cepi secretariat