Dragon09/odtu_chatbot huggingface dataset:
integrating multidisciplinary expertise in a learning and adaptive european pandemic preparedness system

the covid19 pandemic has exposed a global need for accelerating research improving surveillance and efficiently developing countermeasures against pathogens with epidemic and pandemic potential leaps aims to demonstrate the value and feasibility of a proactive policysupporting strategy for genomic surveillance and for pandemic preparedness and response by delivering a systemwide stakeholdervalidated proof of concept validated in 4 eu countries of a learning and adaptive european pandemic preparedness system against pathogen x leaps will fill the gaps observed by global eu hera and national stakeholders in pandemic response by demonstrating the feasibility of combining genomic one health surveillance with genomic epidemiologic modeling for detailed pathogen understanding and precise public health intervention design leaps formalizes dynamic health emergency threat assessment linked to the initiation of governance mechanisms to enable timely decisions in crucial early stages of an outbreak leaps will develop protocols and models for accelerated medical countermeasure development availability and accessibility based on resulting highly effective intervention strategies timely countermeasure access and governance mechanisms modelbased policy support is proposed to health authorities for effective implementable stakeholder cocreated epidemic response scenarios against pathogen x scenarios are evaluated on health socioeconomic and sustainability impact leaps brings together a unique multidisciplinary team with optimal complementary expertise and experience leaps will interact regularly with medical and scientific communities hera and health authorities in order to disseminate relevant and accessible information and during nonemergency periods leaps will validate a roadmap for largescale implementation of leaps methodology by eu level and national authorities and stakeholders in an ecosystem of interlinked actors
identifying atherosclerotic plaques at risk a microstructurebased biomechanistic approach

atherosclerotic plaque rupture in arteries is the primary cause of cardiovascular events such as heart infarct and stroke which are responsible for 45 of deaths in europe plaque rupture is a mechanical event where the collagenous plaque tissue fails to withstand blood pressure loading identifying plaques at high risk of rupture is the key to prevent these fatal events however the current risk assessment strategy fails to achieve this as it lacks mechanistic insights into tissue failure to address this unmet urgent clinical need i propose a paradigm shift to a biomechanistic risk assessment concept i will achieve this with micromechathero project by revealing plaque failure mechanisms and developing a clinically applicable computational risk assessment framework micromechathero will combine exvivo insilico and invivo research exvivo mechanical failure tests on postmortem human plaque samples will involve tissues collagen architecture imaging with recently developed polarizationsensitive optical coherence tomography and fullfield local 3d tissue deformation measurements with digital volume correlation technique this frontier optomechanical approach will revolutionize soft tissue testing and coupled with the virtual fields method will provide unprecedented data for local heterogeneous hyperelastic and failure properties of fibrous plaque tissue linked to the underlying collagen network furthermore a microstructurebased insilico tissue failure framework will be developed using extended finite element modeling technique for plaquespecific risk prediction this computational framework will be validated and tested for its clinical potential in an invivo patient study overall micromechathero will provide a groundbreaking advance in our understanding of plaque rupture and develop a biomechanistic insilico framework for patientspecific invivo risk analysis leading to revolutionary changes in cardiovascular medicine
angular momentum predictions for lowenergy induced fission

nuclear fission the splitting of an atomic nucleus into two or more fragments plays an essential role in both applied and fundamental science however even 85 years after its discovery it remains a challenging puzzle for nuclear theorists a crucial piece of this puzzle is the angular momentum of fission fragments a measure of fragments rotation that has a substantial impact on the emission of neutrons and photons during the deexcitation process recent research on the subject has reignited a longstanding debate on several fundamental questions one key problem involves establishing a comprehensive microscopic theory of angular momentum distributions for the full range of fragments masses and charges these distributions are a major input in the data evaluation process employed to generate the large nuclear data libraries used in fundamental science and nuclear technology however due to the lack of a comprehensive theory those evaluations still rely on simplified and occasionally inaccurate phenomenological inputs the principal aim of this project is to predict angular momentum distributions using stateoftheart nuclear density functional theory combining symmetryrestoration techniques and the timedependent generator coordinate method we will compute angular momentum distributions in fragments for the neutroninduced fission of two crucial actinides 239pu and 235u subsequently we will explore the impact of nuclear excitation on these distributions by extending the finitetemperature formalism to fission fragments the resulting database first of its kind will encompass microscopic angular momentum distributions as functions of the incident neutron energy and the nuclear excitation energy finally we will evaluate the influence of these distributions on predicted fission spectra employing the hauserfeschbach simulator yahfc thus paving the way for fission modeling based on microscopic theory
improving outcomes and impact from scenario based licensing classicalcrisis and cocreated ip

impac3tip is an ambitious coordination and support action that aims to develop pilot and support the sustainable adoption of a scenario based licensing toolbox through a certified user and trainer programme for efficient ip licensing for market uptake and societal value creation impac3tip aims to identify current gaps and shortcoming in available licensing tools for 3 main scenarios stakeholders ip assets and licensing outcomes investigate new and emerging technology trends to support licensing and evaluate the feasibility of incorporating them into the toolbox either now or in the future develop test pilot and refine the toolbox through stakeholder engagement and launch disseminate and sustain the toolbox through a sustainable accredited and certified user and trainer training programme impac3tip academythese objectives are pertinent to the destination of the horizoncl42023human0131 work program to deliver a humancentred and ethical development of digital and industrial technologies particularly by enabling a wider range of desired licensing outcomes alongside pure economic benefit eg impact and socially responsible licensing as well as by systematically expanding the range of ip assets to be supported for licensing beyond the traditional industrial rights for inventions patents and trademarks into more modern bundles of rights needed to license digital technologies including iot ai and ml and mobile technologies eg data sharing and standards essential patents sep the objectives are also pertinent to the workprogramme kso of creating a more resilient inclusive and democratic european society prepared and responsive to threats and disasters addressing inequalities and providing highquality health care and empowering all citizens to act in the green and digital transitions
the blue box a new age for breast cancer diagnostics

the blue box biomedical solutions sl is a deep tech european startup developing a medical device based on artificial intelligence capable of detecting breast cancer using urine samples with 95 accuracy the blue box presents higher performance and safety features as compared to competing technologies mammography mri and gene testing it is noninvasive unlike mammography as it uses urine samples nonirradiating unlike mammography that makes use of radioactive materials user friendly as anyone can perform the test low cost 150 and it can be used by several family members the blue box business plan includes two business models one oriented to final consumers b2c mostly women within the us market and the other one oriented to hospitals and health centres b2b oriented to the eu market the objective of this women techeu project is to assist in the scaling up of the company on the key partners box of the business plan providing support to the outsourcing of 3d printing and hardware assembling experts as well as ip consultants marketing to improve the awareness of the product and improve its visibility and launching and distributing the blue app associated to the device and field tested with voluntaries the product to be developed is a deeptech medical device based on the internet of things iot artificial intelligence ai and cloud computing making use of the latest state of the art discovery of biomarkers to detect cancer and hence fostering a new competitive resourceefficient business model lead by judit gir the founder and ceo of the blue box the blue box has been founded in cooperation between entrepreneurs in spain judit gir taiwan poan billy chen and california where the startup is currently incubated with a clear vision to expand the cooperation between innovation ecosystems in a product by and for women it was envisioned by a woman founded by a woman led by a woman and target clients are women
electrification of heavy machinery

we have invented and developed a specific solution for one of the key components found within most of the worlds excavators cranes construction machinery excess engineering have patented and tested a new revolutionary electric actuator that can replace all type of hydraulic systems electric systems available in the market today has never been able to replace hydraulic systems in construction machines our patented electric actuator has the ability to transfer high loads give the required stroke at a small footprint we are now able to replace hydraulic cylinders in almost every application the technology provides many advantages compared to hydraulic systems including improved energy efficiency no hydraulic oil required reduced need and cost of maintenance and increased service life
quality utility and maturity measured developing a data quality and utility label for healthdataeu

context data users ie researchers innovators regulation agencies and policymakers need highquality data in healthdataeu data holders are expected to make their datasets available for secondary use providing a notion of their quality and utility and the maturity of their data quality procedures in article 56 in the healthdataeu proposed regulation this notion would take the form of a label goal overall quantum aims at developing and implementing a label mechanism that could be ideally adopted in the future healthdataeumethods quantum builds on 5 technical work packages wp wp1 conceptualises and provides technical specifications for a data quality utility and maturity label wp2 designs and tests at smallscale the label wp3 implements the labelling mechanism in a number of data holders wp4 engages the data quality users community and wp5 outreaches other interested parties including other initiatives building healthdataeuexpected results a a common concept of datasets quality and utility and data holders maturity b technical specifications for the label deliverable d11 and d12 c a conformance checking tool that yields the label d21 d an implementation report of the label mechanism d31 e recommendations for a largescale implementation of the quantum label mechanism d32 and f the quantum exchange platform and academy d42 and d43 as instruments for capacity buildingconsortium for this purpose 27 beneficiaries 5 affiliated entities and 3 associated partners the composition of the consortium seeks to reflect the different roles and institutions in the governance of the healthdataeu virtually consider all types of data and science of interest and gather the expertise of previous outstanding projects in the domain
smart communityled transition for europes rural areas

depopulation mostly characterized by emigration of young people is occurring in rural areas all over europe this has brought to an ageing phenomenon as well as the emergence of several structural problems such as fewer job opportunities degradation of infrastructures and a decreasing offer of services of general interest however the revolution in digitalisation with an increase of remote and locationfree work opportunities is offering the chance to redirect some rural migration flows back interventions are thus needed to take up this opportunity and build on trends such as multilocal living to promote new greener smaller sustainable and innovative growth models it is there where smart era intervenes the project will foster resilience in rural areas by upgrading and codesigning codeveloping and covalidating with local communities a set of smart solutions integrated within smart innovation packages sips able to tackle pressing socioeconomic and environmental challenges and promote a communityled transition pathway that will empower rural people to act for change smart eras main ambitions are a building the first largescale europeanwide solution for systematic rural data screening and smartness analysis b using codesign methods and techniques to involve residents and stakeholders in the design and validation of sips as well as in the collection of old and creation of new data sources c proposing a unified smartnessdigital maturity assessment method d providing unique and timely evidencebased and performancefocused recommendations to upgrade the new local national and european policy instruments and enhance their efficiency and efficacy in supporting smart villages across the eu e fostering cooperation among pilot regions as well as among the four eu macroregional strategies and improve their rural communities ability to address socioeconomic and environmental challenges
ri policy making implementation and support in the western balkans

the project supports the policy dialogue including formal meetings monitoring and agenda setting capacity building and implementation of the eus western balkan agenda as well as the aligning of thematic priorities it implements regional pilot activities and upgrades an information hub based on the wbcrtiinfo platform14 partner organisations representing network nodes in the region and eu expert organisation support policy dialogue through ministerial meetings steering platform meetings and adhoc policy meetings they provide analytical evidence via monitoring and mapping activities of the stakeholder ecosystem implementation of the western balkans agenda and integration to the european research area and foresight policy answers also allows for tailored and targeted capacity building activities in the western balkans as well as regional alignment in relation to the digital transformation the green agenda and towards healthy societies pilot activities provide learning opportunities on policy and programme level and reach out to final beneficiaries related to improved academiaindustry cooperation researcher mobility youth promotion of research infrastructures and increased innovation skills in all areasthe project builds on existing information hubs for example wbcrtiinfo and continues services such as regular newsletters media relations production of infographics and multimedia content special emphasis will be put on the inclusion of underrepresented groups and the coordination with key stakeholders and international organisations
building a european network for the characterisation and harmonisation of monitoring approaches for research and knowledge on soils

soil health is crucial for challenges related to climate environment and society as such this soil health and food mission proposal directly links in to the other he missions as well as to the european green deal and farm to fork strategies both public and private sectors are proposing a sustainable vision that depends on a reliable assessment of the effects of management and policy innovations on soil health therefore there is an urgent need to ensure that the eu sets the benchmark of a reliable costeffective framework for measuring soil healthin alignment with existing initiatives such as eu soil observatory ejp soil and the lucas topsoil survey and using open science approaches the benchmarks consortium will codesign an integrated soil health monitoring framework this framework will build upon the assessment of soilbased ecosystem functions to codevelop an interactive soil health dashboard for 1 the selection of appropriate soil health indicators 2 soil health assessment and indexation and 3 recommendation of management practices to support soil health the dashboard will be suitable at local landscape regional and european scales for a variety of stakeholders in urban agricultural and forestry land use systems benchmarks indicators will be relevant to the stakeholders objectives applicable to the different land use systems and pedoclimatic zone and appropriate in terms of logistical financial and sensitivity requirements to inform on the appropriate spatial resolution of indicators the soil health mission and benchmarks proposed indicators samplebased measurements stats data and model derived measurements space earth observation techniques and citizen science observations will be tested in 24 living labs across europe finally benchmarks will support policy development and valuechain innovation through increased evidence on the links between soil health functions and ecosystem services
the transcriptional response to oxidative stress

environmental stress triggers a cellular response to promote adaptation and survival typically through activation of stress genes what is less appreciated is that various types of cellular stress at the same time induce widespread transcriptional repression at most other genes although such transcriptional reprogramming is common to various kinds of cellular stress recent evidence suggests it is governed by different stressspecific mechanisms a brief exposure to oxidative stress leads to a rapid and transient global repression of transcription however our current knowledge about the oxidative stress response is extremely limited based on our preliminary results i hypothesise that the transcriptional response to oxidative stress involves both regulation of transcription elongation as well as termination and that these are connected to posttranslational modifications of rna polymerase ii rnapii itself here i propose an ambitious approach to investigate the transcriptomewide oxidative stress response in human cells and following physiologically induced oxidative stress in mice to this end we will use a combination of stateofthe art sequencing techniques coupled with timeresolved proteomics and a novel screening approach together our work will provide important new knowledge about the transcriptional response to oxidative stress and the factors involved in an area that is currently not well understood such knowledge is also crucial to understand the fundamental mechanisms allowing rnapii to stop transcribing and restart again finally we will investigate how factors involved in the transcriptional response influence transcriptionassociated genome instability and neuronal cell identity this will be relevant for diseases in which oxidative stress has been implicated such as neurological disorders and cancer
photonic multibeam beamforming technology enabling radarlidar multisensor fusion platforms for aerospace and automated driving applications

paralia will enable an agile lowcost and energyefficient multisensor combining radar and lidar technologies will rearchitect the sensors ecosystem upgrading their capabilities and enabling ultrahigh resolution at ultralong distances crucial for current and futuristic automotive and aerospace applications to this end a common lidarradar optical multibeam beamforming platform will be developed based on the bestinclass multiport linear optical xbar architecture previously used for neuromorphic applications for its implementation paralia will utilize hybrid inpsin integration while leveraging a tight integration of inp components in multielement arrays and the advances in sin pzt optical phase shifters with sreconfiguration time and low power consumption 1uw to demonstrate the universality of the developed optical multibeam platform number of lidar and radar will be developedi two multibeam lidar modules featuring 120 degrees horizontal field of view fov and 30 degrees vertical fov and supporting 8 and 64 independent beams with 64 independent beams based on 8 wavelengths 8x8 xbar architecture ii two multibeam radar modules operating at k and e band for aerospace and automotive industries respectively both radar modules feature 120 degrees vertical and horizontal fovs and support 8 independent beamsiii a multisensor module combining the radar and lidar modules with a processing unit employing a fusion ml algorithm developed to acquire and process the information coming from the multiple beams of the multisensor greatly enhancing its range and resolution
high energy density and long cycle life nearneutral znair rechargeable batteries using polyoxometalates nanoclusters as homogenous catalysts

even though liion batteries have dominated the market so far they lack the desired properties for large scale electric grids or electric vehicles besides there are some concerns regarding the safety and rawmaterials availability in the future in this context znair batteries emerge as the most promising candidates to be the postlithium technology for their lower weight and volume and inherently safety however their cycle life is still below the required standards therefore the goal of this proposal is to develop efficient electrically rechargeable znair batteries with high energy density and cycling stability to achieve this near neutral electrolytes will be used instead of traditional highly alkaline solution employed in nonrechargeable devices the latter leads to significant improvements in zn anode cyclability increasing battery life however to fully exploit the potential of this technology bifunctional catalytic materials specifically design to operate in this ph conditions are necessary and still missing this project seeks to address this matter using metal oxide nanoclusters known as polyoxometalates pom as homogenous bifunctional catalyst to promote both oxygen evolution and reduction reactions these materials have outstanding electrochemical properties including an excellent reversibility which makes them ideal for rechargeable energy storage devices this research plan will investigate the electrocatalytic activity of various poms in near neutral electrolytes using several electrochemical techniques these will be later test in labscale znair batteries to assess the performance of poms as bifunctional catalyst in real operating conditions the combination of nearneutral electrolytes and pombased air cathodes is expected to allow fabrication of zab devices with increased cycle life specific and volumetric energy density and power density these improvements will consolidate zab secondary batteries as a postlithium technology