Dragon09/odtu_chatbot huggingface dataset:
the subjective effects of oppression anna julia cooper and black existentialism

by going back to anna julia cooper an important though understudied figure of the end of the 19th and the beginning of the 20th centuries the present project draws on my doctoral research in critical phenomenology of lived oppression and applies it to the analysis of the transatlantic constitution of black existentialism the importance of issues related to intersectionality within existing feminist movements led me to question the history and conditions of emergence of these issues it made a decentering necessary in order to illuminate the present from another geographic space the united states and according to a longer history by tracing the genealogy of intersectional thought i wish to make feminist thought more complex from its margins and from a philosophical perspective black existentialism in which womens figures are still underrepresented
dissecting a stepwise principle of cellular diversification to instruct regeneration in the enteric nervous system

the enteric nervous system ens contains a large range of neural subtypes that collectively controls essential gut functions independently of the central nervous system cns although the ens is capable of forming new neurons following injury or inflammation it fails to regenerate completely my lab recently established a molecular classification of enteric neurons and discovered that they diversify through a conceptually new principle during development only two neuronal identities form during neurogenesis while all other classes emerge through subsequent differentiation at the postmitotic stage this stepwise conversion process contrasts from the better understood cns development where spatial patterning of stem cells predominates cell fate decisions dissecting the molecular basis for the sequential acquisition of cell identities in the ens will advance our fundamental understanding of cell heterogeneity emergence in divensify we propose to push new frontiers in neuronal identity formation to facilitate constructive regeneration in the adult gut combining single cell rna and chromatin profiling we will assess the role of pioneering transcription factors and competent cell states in each step of differentiation we will dissect gene regulatory networks and identify key determinants using ultrasoundguided gene manipulation a novel method we recently developed to target the otherwise inaccessible ens in utero we will determine how injuryinduced adult neurogenesis correlates with developmental paradigms and leverage knowledge on latent potentials and intrinsic transcriptional regulators to engineer specific neuron types through viral gene manipulation in the adult gut the proposed project will transform our comprehension of neuron identity formation and maintenance and provide proofofprinciple experiments that open for selfrepair strategies to treat neurological gut disorders
mass spectrometry assisted sustainable green approaches for food safety and authenticity

the agrifood chain from the original product to its commercialization has thorough controls authenticity and food safety are highly supported by protocols and are legislated by different organizations plasmof aims to propose novel cuttingedge solutions based on stateoftheart mass spectrometry ms and novel design materials the use of novel ionization methods based on dielectric barrier ionization dbdi and green sample preparation techniques enhanced by using metalorganic frameworks mofs may provide unprecedented advantages in solving relevant food quality and safety this project proposes novel approaches based on the synergic use of advanced materials and ambient mass spectrometry for some of the challenges that need to be addressed in the agrifood sector related to their quality authenticity and safety plasmof proposed the synthesis characterization and application of metalorganic frameworks mofs as novel sorbent materials in miniaturized solidphase schemes spe in a second stage the elaboration of novel devices based on mofs and their combination with dbdbased ambient ionization methods for relevant societal applications different dbdbased tools configurations will be tested as ionization methods in food authenticity including tworing electrode dbdi flexible microtube plasma ftp active capillary sampling plasma source acapi and lowtemperature plasma ltp these novel technologies will be implemented for the assessment of virgin olive oil voo authenticity and to detect frauds in voo and in other food products such as wine
nextgen fluorescence imaging for research and theranostics

fluorescence microscopy is key technique in the life sciences though the method struggles to deliver the fast and sensitive imaging of multicellular systems such samples are now becoming commonplace not only in research but also in clinical use including spatiallyresolved omics and theranostics based on patient material that allow the development of personalized treatments however their general uptake is limited by the absence of suitable instrumentationas part of our ercfunded research we have invented the triscanner a novel fluorescence microscope that offers transformative imaging performance much faster imaging higher resolution higher sensitivity and is also simple robust and affordable our triscanner readily addresses an urgent need in current research and healthcare research and is wellpositioned to scale out from research into workhorse usage in industrial rd and diagnosticswe propose to develop this idea from a concept and lab prototype into a robust demonstrator that is showcased on a variety of highlyrelevant applications and that we will leverage to raise user awareness and interact with key leaders in academia and leading commercial partners this project will furthermore allow us to explore the business case and market potential in view of developing and selecting the optimal valorization track we expect to deliver societal impact by providing unprecedented new imaging capabilities in a fastmoving and highly influential research field
integrated process for seawater electrolysis using a pgmfree anion exchange membrane stack

asterisk proposes integrating seawater treatment and green hydrogen production using a platinum group metal pgmfree anion exchange membrane aem electrolyser the consortium will work on developing aem stack components compatible and stable under saline conditions namely water oxidation and water reduction electrocatalysts anion exchange ionomers and membranes porous transport layers and electrical contacts asterisk will incorporate a minimal seawater treatment step before the stack to remove biological organic and suspended solids content with minimal energy requirements and operating costs leaving the ions naturally present in seawater to enter the stack the project will meet the challenging kpis set by this call and significantly improve upon the degradation rate of 5 over 500h operation leveraging the current experience on materials and membranes design already developed in ongoing projects involving several asterisk partners a final asterisk demo will achieve up to 100 gh2h production on a 5 kwe stack operating for 2000h to achieve the goal of reaching trl 4 at project endthe technical work will be complemented with an ecodesign process supported by an environmental and socioeconomic analysis to guide the development of a low impact and circular designed aem device maximising socioeconomic benefits a technoeconomic and exploitation plan to move from laboratory scale singlecell to a multistack electrolyser will be studied to ensure a fasttrack to commercialisation if successful asterisk will advance costeffective and sustainable green hydrogen production and contribute to the european unions longterm carbon neutrality and renewable energy leadership goals
programmable bionanomaterials with proteincontrolled behavior

programmaterial is a research and innovation staff exchange network dedicated to pushing the boundaries of nanomaterials and nanotechnologies by introducing integrated proteincontrolled behaviors our primary goal is to craft hybrid nanostructured materials featuring precise structural functional and spatiotemporal behaviors directly regulated by specific proteins by incorporating synthetic biology components these materials will demonstrate the ability to perform tailored chemical or biological functions guided by specific proteins this innovation holds tremendous potential for groundbreaking applications in biomedical and healthcare contexts while traditional approaches focus on engineering nanomaterial properties to influence biological entities programmaterial pioneers biobased control over nanomaterial properties emphasizing programmable influences of biomoleculesparticularly proteins programmaterial seeks to cultivate a new generation of scientists at the intersection of materials science and biotechnology this expertise will drive innovative solutions in advanced healthcare nanomaterials fostering unprecedented interactions with biology particularly in precision and nanomedicine applications to achieve these ambitious goals we have united 9 academic partners and 1 nonacademic partner in a collaborative network this team spans european and extraeu institutions usa australia argentina switzerland japan and encompasses individuals ranging from phd candidates to experienced researchers our diverse composition ensures programmaterials robust interdisciplinary and intersectoral dimension vital for a broad and effective impact the program places a strong emphasis on actively involving young professors providing pivotal support for their career progression knowledge transfer and associated training activities are crafted to equip scientists with specific competencies in materials science bionanotechnology and nanomedicine
express 2 specify and protect the eu social contract express2

express2 is a project that addresses from a multidisciplinary interdisciplinary and crosssectional perspective the growing demand for a new more democratic inclusive and sustainable social contract in the eu to achieve this the project will work to create a more appealing and legitimate eu social contract draft that will be submitted to inhabitants member states and eu institutions that will have the possibility to participate and decide upon the conditions rights and obligations to be binding the goal is to strengthen the eu agreement of association by promoting social dialogue civic engagement and integration an express draft shall be achieved by means of policy dialogue campaign implementation collaborative workshops advocacy planning and innovative offline and online formats and tools to create spaces for dialogue to this end express2 will involve eu policymakers and institutions throughout the project to obtain a more appealing and legitimate eu social contract draft the project will also focus on identifying and analyzing disruptive elements of the social contract such as insecurity populism climate change mistrust in institutions gender discrimination digitalisation and pandemics the analysis of these stressors includes both individualised and crosssectional approaches to cover the plausible relation of multiple disruptors their concatenation or the trigger effect of a disruptive phenomenon to another by understanding these disruptive elements and their effects on the social contract the project will propose concrete measures to ironclad the social contract and it will provide relevant information to protect it from actual and potential disruptions thus we conceive social contracts as incomplete theorised agreements and living documents in addition to academic policy and socioeconomic outcomes express2 will propose recommendations to strengthen the social contracts resilience and capacity for further development
insilicohealth training the virtual twin professionals to support healthy ageing

insilicohealth aims to train doctoral candidates in the field of virtual human twin technology with a specific focus on addressing challenges related to healthy aging in europe in three core domains heart musculoskeletal and brain there is a twoway transfer between the research projects and the interdisciplinary training programme in which candidates will receive a broad education that spans different fields relevant to digital health a compelling interdisciplinary joint degreedn programme for 11 dcs is proposed answering four interdisciplinary research objectives shouldered by intersectoral training components ie academic and nonacademic secondments to prepare a new generation of outstanding digital health professionals insilicohealth will provide a comprehensive and forwardlooking programme that combines research interdisciplinary training and collaboration with industry to address the complex challenges of healthy ageing using virtual human twin technology the dcs will be actively encouraged to surpass the technologydriven focus and to explicitly addressing the ethical legal societal implications of vht technologies by providing the dcs with a 360 view on the methodological technological ethical social and regulatory challenges associated with this digital revolution of healthcare insilicohealth is conceptualized as a steppingstone for a sustainable eubased doctoral programme on in silico health
accelerating era by sharing unique talents for healthy life and environment

erashutlle is creating a crosssectoral framework for collaboration and possibilities for talents from different backgrounds to address contemporary health and environmental challenges and produce innovative solutions for the benefit of society the erashuttles main goal is to foster ri capacity in the era to benefit the participating widening countries poland croatia and malta this will be accomplished by bolstering ri support capacities boosting crosssectoral collaboration and implementing crosssectoral knowledge valorisation and talent circulation experiments while boosting the attractiveness of regional ri ecosystems this action is designed by leading research universities from widening countries with underdeveloped ri landscapes and strong nonacademic institutions and associations from nonwidening countries such as steinbeis cericeric and astp the erashuttle brings universities nonacademic and private organisations together to eliminate existing barriers and work toward a common objective by offering training and secondment opportunities that celebrate diversity project partners will develop their core capacities and benefit from era knowledge and expertise exchange the project supports industryresearch needs by crossfertilizing ideas to address hurdles and low levels of research valorisation following the european industrial strategy and the european skills agenda erashuttle will help ri talents from widening countries deepen their capacity and broaden their skill set to improve research knowledge valorisation and crosssectoral collaboration through specific objectives project will identify research institutions strengths and weaknesses and increase access integration and use of research equipment and knowledge improve research conditions employability and career possibilities to attract and retain top research and innovation talent in expanding countries and implement crosssectoral talent mobilities
building economic needsbased and environmental evaluation frameworks for inclusive transformation of social services in europe

benefits will develop a holistic appraisal framework haf to measure the social economic and environmental valueadded of social services haf consists of a set of innovative research technology and experimental solutions based on active citizen engagement to provide wellfounded evidence on the social and economic returns of social services haf will leverage existing innovative beyond gdp valuation methods leveraging insights from economics social behavioral and political sciences as well as citizens and policymakersupon this preparatory work benefits will set up a research and engagement plan to identity measure and visualise the social economic and environmental valueadded of social services as well as the enabling inhibiting and mitigating factors that will allow to scaleup the positive effects of social services while ensuring a prosperous inclusive and just transition benefits will consolidate these findings through setting up a a social services policy observatory sspo which will document assess evaluate and codesign policies across multilevel governance in the eu and b citizens assemblies integrating participants from all backgrounds to deliberate on proposed policies these two activities will also be facilitated through benefits visualisations platform vp an innovative technological solution which will collect document and visualise data from various sources ie social media news outlets web on issues related to provision of social services welfare and prosperity providing citizens stakeholders and policymakers the necessary information to promote change through data and insights collected from the research experiments sspo and vp benefits will build a policy evaluation toolkit evalkit which will inform policy making though codesigned recommendations with the aim to promote the uptake and value scaling up of social services
higherorder hodge laplacians for processing of multiway signals

network analysis has revolutionized our understanding of complex systems and graphbased methods have emerged as powerful tools to process signals on noneuclidean domains via graph signal processing and graph neural networks the graph laplacian and related matrices are pivotal to such analyses i the laplacian serves as algebraic descriptor of the relationships between nodes moreover it is key for the analysis of network structure for local operations such as averaging over connected nodes and for network dynamics like diffusion and consensus ii laplacian eigenvectors are natural basisfunctions for data on graphs and endowed with meaningful variability notions for graph signals akin to fourier analysis in euclidean domains however graphs are illequipped to encode multiway and higherorder relations that are becoming increasingly important to comprehend complex datasets and systems in many applications eg to understand groupdynamics in social systems multigene interactions in genetic data or multiway drug interactionsthe goal of this project is to develop methods that can utilize such higherorder relations going from mathematical models to efficient algorithms and software specifically we will focus on ideas from algebraic topology and discrete calculus according to which the graph laplacian can be seen as part of a hierarchy of hodgelaplacians that emerge from treating graphs as instances of more general cell complexes that systematically encode couplings between nodetuples of any size our ambition is to i provide more informative ways to represent and analyze the structure of complex systems paying special attention to computational efficiency ii translate the success of graphbased signal processing to data on general topological spaces defined by cell complexes and iii by generalizing from graphs to neural networks on complexes gain deeper theoretical insights on the principles of graph neural networks as special case
advanced biobased refinery intermediates

the abate project aims to upscale and demonstrate in an industrial relevant scale a complete sustainable value chain based on the integration of thermochemical and biochemical technologies for the valorization of lignocellulosic residual and nonfoodfeed biomass into costcompetitive carbonneutral advanced biobased intermediates abates to directly substitute fossil hydrocarbons in conventional oil refineries the technology was validated in trl5 via a horizon 2020 project biomates which involved a twostep valorization of lignocellulosic biomass in abate residual lignocellulosic biomass is firstly converted into fast pyrolysis biooil fpbo and biochar co2 from the fpbo production will be sequestrated and converted into methanol enabling the mitigation of ghg emissions of the pyrolysis step as well as sideproduction of green methanol secondly the fpbo is stabilized into a highquality advanced biobased intermediate which can be directly fed in conventional refinery plants enabling the direct decarbonization of the refining sector as well as of the transportation fuels and chemicals the stabilization will be performed via a single hydroprocessing step which incorporates several innovation systems and designs ie a novel catalytic system abiding to fpbo acidity and solids content optimal energy integration as well as its integration with green h2 and a biochemical ccu unit the abate end use will be demonstrated via cofeeding with refinery intermediates rendering hybrid marine and aviation transport fuels as well as feasibility and business plans abate technology may satisfy over 55 and 5 of the eu renewable marine and aviation fuels demand by 2035 respectively the abate project aims to scaleup and intensify the technology to reach 90120 ghg emission reduction according to red in industrial scale by optimized processes and their integration with res components ie green h2 minimizing the use of fossil energy inputs
differentiation and characterisation of brainderived extracellular vesicles from the peripheral blood for understanding the neuropathophysiological mechanisms of migraine

migraine is a major disease burden on society but remains poorly understood the onset of migraine with aura has been linked to cortical spreading depolarisation csd and professor turgay dalkara the supervisor found that inducing csd in animal models led neurons to release inflammatory proteins in extracellular vesicles evs because brainderived bdevs cross the bloodbrain barrier and their composition reflects their cellular and temporal origin they represent biomarkers that if isolated from the peripheral blood of migraine patients could give an unparalleled insight into cellspecific neuroinflammation in migraine however current methods to isolate cell typespecific bdevs from the blood insufficiently distinguish them from evs of other tissues obscuring crucial insights into cellspecific processes here i adam bennett the researcher will develop a workflow to isolate cell typespecific bdevs from the blood of migraine patients then temporally characterise them to gain a celltype specific molecular signature during migraine with aura this will firstly involve the optimisation and validation of isolating neuron astrocyte and microglia evs using a panel of specific markers from the brains and peripheral blood of rats secondly cell typespecific evs isolated at different time points postcsd evocation in rats will be characterised using proteomics to generate temporal cell typespecific data on the pathological processes postcsd thirdly with optimised time points cell typespecific evs will be isolated from the blood of patients after migraine with aura onset and characterised in doing so i will 1 identify previously unknown biomarkers to deepen our understanding of migraine with aura with possible treatment derivations 2 create a tool for researchers to investigate other neurological conditions through analysing cell typespecific bdevs 3 develop my skillset publication record visibility and networks to advance my career