Dragon09/odtu_chatbot huggingface dataset:
shedding light on the key molecular determinants regulating 3d diffusion and activity of antimicrobials in bacterial biofilms

bacterial biofilms are associated with approximately 17 million hospitalacquired infections annually in the united states incurring an annual economic burden of about 11 billion dollars the role of biofilms in antimicrobial resistance amr is highly complex and may significantly drive resistance biofilms can act as a diffusionlimiting barrier against various antimicrobials resulting in limited drug access into the bacterial cells the evaluation and quantification of biofilm diffusion is essential since it is a poorly researched topic and the matrix properties are necessary to define the bacterial populations within the biofilm in this project an antimicrobial peptide amp will be used as a model molecule because amps are known for their activity against biofilms and have been considered promising antibiofilm agents the vcpp2319 a peptide developed by the instituto de medicina molecular team imm was chosen for the project as a diffusion model reporter the research plan is organized into three scientific work packages wp wp1 aims at studying the fundamental properties of biofilms whereas wp2 and wp3 aim at studies using vcpp2319 and the library of its variants respectively as molecular models to elucidate their diffusionrelated properties in biofilms and correlate antibiofilm activity with the metabolic status of biofilmembedded bacterial cells the project will use two reference and two clinical strains of staphylococcus aureus and klebsiella pneumoniae as models these bacterial species will be selected because they are clinically relevant pathogens frequently associated with biofilm infections overall the projects relevance is overcoming the gap of knowledge associated with molecular diffusion in biofilms and relating the diffusion of antimicrobials within biofilms with their activity this will enable the future development of innovative chemotherapies to fight against biofilmrelated infections
modular axial flux motor for automotive

the massive electrification of automotive vehicles will necessarily involve the development of low cost highly compact and low environmental impact electrical machines em the objective of the maxima project is to develop and validate a complete methodology to design an em as well as the associated production system for the automotive core market this methodology will have to deal with often incompatible constraints such as efficiency costs reduction high performances in terms of powertorque density and high recyclability especially for critical raw materials to achieve this objective maxima will focus on a dedicated topology axial flux synchronous machine afsm asfm currently on the market are very efficient but cover only a niche market due to their high manufacturing costs they also offer strong exploited or unexplored options in terms of topologies and materials unlike radial flux ems the margin for improvements of afsm is really significant by acting on both em design and manufacturing process flow thus allowing higher performances and lower cost while keeping a low environmental impact the consortium brings together research teams and companies from the entire value chain from raw material suppliers to car manufacturers along with a recycling company together they can face the main technological and scientific challenges in the electromagnetic mechanical and thermal fields reaching a solution close to market at the end beside high trl5 prototypes the project will provide a validated methodology to accelerate the design thereby reducing the time to market and new technologies such as em digital twins to operate ems to their full potential
optoelectronic neural connectoid model implemented for neurodegenerative disease

a major challenge facing europe is its ageing population and associated increase in diagnosed cases of neurodegenerative diseases ndd parkinsons disease pd is associated with tremor and loss of motor functions due to progressive degeneration of dopaminergic neurons in the brain this can lead to memory loss and dementia which is associated with short and longterm injuries and disabilities with emotional financial and social burdens for patients families and society the exact causes and mechanisms underlying pd are still unknown and existing treatments focus on alleviating symptoms and increasing quality of life but do not halt or reverse disease progression although animal models give unique possibilities to study physiological and behavioural mechanisms drug development fails due to lack of translation to humans alternative nonanimal ndd models is needed both in terms of better translation but also to replace expensive and problematic animal experimentswe will move disease modelling to a new level and replace animal models by creating a new concept we call connectoids we will develop an exvivotype in vitro human optoelectronic multiregional brainorganoid disease model in which connectoids are formed by precise spatial arrangement of brain organoids connected via hydrogel tracts that promote axonal pathfinding functional connection and signalling by developing 1 light controllable subtype specific neurons within regionalized brain organoids and 2 electrodes and waveguides that can penetrate the organoids able to monitor neurotransmitter signalling inside and between the organoids we will for the first time be able to sense how a particular brain region responds to a certain therapy and watch in real time how signals are transmitted to other brain regions our model will not only have health benefit but will relieve a heavy economic burden on society and open up for new possibilities for technological and economic development
innovative strategies for containership fires prevention and management

maritime transport represents the centre of global trade with about 90 of the goods volumes and values worldwide nowadays containerships are built with the same basic design principles as the older smaller container ships without accounting for possible consequences that could impact safety cargo fires represents one of the most important threats of this kind of ships also for ferries with container on the truck on one hand fire causes large losses of humans andor cargoes on the other hand fire is impacting coastal zone and marine protected areas currently there are no requirements for the installation of fixed fire detection systems above the weather deck of a container ship innovative strategies for containership fires prevention and management overheat main goal is to prevent and manage in case of occurrence fire accidents on board of containerships overheat brings novel fire management solutions for prevention early detection and response which are key aspects to assure safety of people and the protection of the environment the development of a digital solution ds will provide the overall situational picture on board and surrounding the vessel furthermore integration of iot sensors fixed and mobile and uas will provide the adhoc system for the prevention early detection and rapid response of fire best practice and assessment of safety culture will be conducted to prevent fire and understand how people perceive safety hence overheat prepares a truly new generation of digital fire management solutions complete seamless real time and in line with imo regulations integrated in the vessel it infrastructure the impact of the proposed solution will be initially evaluated by performing validation activities in simulated environment and then executing demonstration activities in a real environment with use cases that will be identified described and detailed during the research activities to prove the feasibility and benefits
improving micropollutants analysis and controlling of terrestrial and aquatic systems

degradation of plastics is a sequence of chemical and physical changes reducing their molecular weight and mechanical integrity of the polymer and leads to formation of microplastics mps negative effect of the mps on the environment is not only physical but also chemical due to their ability to adsorb and accumulate many persistent organic pollutants the role of mps as a vector of the contamination is newly formed phenomenon and could fundamentally top off the role of mps in the ecological systems only limited number of scientific papers and research are currently available and published thus impactas project aims to change it university of las palmas de gran canaria provides unique opportunity to study micropollutantsmicroplastics topic in terms of islands location extensive tourism industry protected natural parks excellent infrastructure and knowledge of environmental analytical chemistry research group belonging to institute for environmental studies and natural resources project will focus at few objectives development of analytical methodologies and strategies for the determination of organic pollutants adsorbed on mps spatial and temporal monitoring of micropollutants microplastics in different environmental compartments and environmental risk assessment of micropollutants in different natural ecosystems objectives of the project are multidisciplinary including combination of analytical chemistry statistics biology and environmental sciences impactas implies international research visits and placement of the researcher for further knowledge implementation expected results have potential to provide state of the art solutions for micropollutants monitoring and control in different environmental and biology systems around canary islands which could be transferred across research groups within eu countries this project is in line with the eu strategy for plastics in a circular economy and blue growth strategy of the european union
preclinical in vivo validation of a glioblastoma neuro snooper electrical device

median survival for people that are diagnosed with glioblastoma gbm is only 15 months chemoradiotherapy and targeted therapies still fail to combat peritumoral relapse after tumour removal preventing peritumoral brain invasion is the main target to cure gbm our project aims to validate a proofof concept for a new medical device md gbm neuro snooper in gbm animal models a required step before initiating a clinical trial technology readiness level from 23 to 4 this md will allow to define an insitu electrophysiology profile of patients with gbm after the tumor resection to access a new mechanistic understanding in the brain tumour field as well as new strategies for patient stratification and treatment already existing mds with electrode wires are either very stiff or with a millimetric dimension the erc work will lead to a first generic miniaturised prototype implant with moderate invasiveness and which design was validated in connection with neurosurgeons for the gbm application validation of its freedom to operate in the context of continuous ip landscaping and the creation of an exploitation plan in a longterm perspective it will help characterise hyperexcitability in brain diseases such as tumors but also epilepsy or the alzheimer disease we will also investigate the effect of stimulation of the peritumoral tissue and the correlation with the recorded signals as a new electrotheragnostic strategy we will address the ethics and social dimension of using such a md and our exploitation plan will include the protection of intellectual property business strategy and the preparation of a clinical trial after project completion the project will be performed by a dedicated team that includes significant expertise in technical development preclinical validation of devices surgery and knowledge transfer
disrupting the horticulture industry with smart lighting solutions

artificial lighting systems are holding back wide adoption of vertical farms due to 1 high energy costs and 2 inability to fully replicate the sun spectrum it also affects greenhouses profitability as they also depend on artificial lighting systemsminisun is the most energyefficient lighting system for the horticulture industry 50 reduction compared to existing technologies able to fully mimic the sun spectrum based on groundbreaking luminaires that combine proprietary led and smart driver technologies with stateoftheart sensors and aiml algorithms with minisun indoor farming becomes profitable for a variety of crops eg cucumber berries tomato pepper making it possible to grow them in vertical farms for the very first timeour circular business model low capexopex recurring revenues over time will enable rapid growth our vision is to become a world leader in the horticulture led lighting market addressing a 10 of the market share by 2030
nanoengineered photoactivated drugfree antimicrobial precision treatment for chronic skin wounds

antibioticresistant bacterial skin and soft tissue infections sstis are difficult to diagnose and treat prolonging hospital stays and lowering quality of life chronic wounds harbour antibioticresistant microorganisms that form biofilms leading to conditions like diabetic foot ulcers dfus approximately 50 of dfus become infected making them the most prevalent and costly diabetes complication with a higher mortality and morbidity risk from lower limb amputation there is an urgent need to develop effective localised solutions for treating sstis that do not depend on antibiotics especially against complex biofilms like those occurring in dfu casesin this proof of concept project we will evaluate a photocure wound patch a porous nanothin agtiox film with visiblelight photocatalytic activity that produces superoxide radicals to effectively eradicate biofilms in the sstis context the patch boasts enhanced mechanical stability for durability and sustained activity across multiple irradiation cycles offering a viable option for recurrent treatment photocure patch presents a more efficient drugfree alternative to conventional antibiotic treatments with reduced adverse effects addressing the escalating challenges of antibiotic and multidrug resistancethe project will validate the antimicrobial efficacy of tioxpolymer nanocomposite patches against both single and multiplespecies biofilms relevant to chronic sstis notably dfus using ex vivo and in vivo humanrelevant models subsequently we will devise a comprehensive ip strategy secure initial patents and conduct thorough market and competitor analyses within the antimicrobial wound care dressing sector finally we will outline a detailed business case for advancing the photocure prototype to market
quantifying the formation and evolution of the archaean lithospheric mantle

the formation of the archean lithosphere was a key event in earth history resulting in the construction of the first continents or cratons the lithosphere formed by extensive mantle melting however there are conflicting models for the environment in which melting took place efforts to understand the formation of the cratonic lithosphere are hampered by a lack of quantitative information on the depth of mantle melting and the original thickness of the archean lithosphere exsolved orthopyroxenes within peridotite xenoliths and silicate inclusions in diamond hold the key to constraining these critical parameters we will reconstruct the original compositions of an extensive collection of exsolved orthopyroxenes and use our recently published thermodynamic model to calculate their formation pressures and temperatures this innovative approach will reveal the depth extent of archean melting we will provide the first constraints on the vertical extent of the lithosphere in the archean using geothermal gradients calculated from dated diamond inclusions to achieve this we will perform cutting edge laser ablation upb dating of garnet inclusions this challenging application has yielded promising results for xenolithic garnet observations will be complemented by new experiments using fertile depleted and silicaenriched compositions coupled with with thermodynamic modelling which will lead to a better understanding of phase relations during peridotite melting the origin and significance of silica enrichment is poorly understood we will conduct meltrock reaction experiments to test the hypothesis that silica addition occurred via interaction with ascending komatiite melt we will thus address several fundamental issues the depth of archean mantle melting the origin of silica enrichment and the link between cratonic peridotite and komatiite magma litho3 will provide unprecedented insight into the formation and evolution of the cratonic lithosphere
3d cuprate twistronics as a platform for high temperature topological superconductivity

2d superconductors can be used to build ultraclean interfaces for josephson junctions the superconducting analog of a transistor a small twist in the relative crystal orientation of 2d superconductors could become a new platform for topological superconductivity an exotic state of matter that holds great promise for quantum computing at high temperatures based on my methodological developments for the realization of twisted cuprate ultraclean interfaces the field is rapidly evolving and these interfaces are now the leading candidate for the implementation of hightemperature topological superconductivity however the combination of wellcontrolled twisted cuprate heterostructures and complex circuits calls for new experimental methodologies3dcut will develop micronanodevices and techniques to fabricate and control cuprate van der waals twisted heterostructures in threedimensional nanoarchitectures 1 we will develop novel fabrication tools to integrate complex thermal and superconducting circuits in fragile twisted cuprate bilayers we will explore if a topological gap opens near magic angles in twisted bilayers by studying the josephson effect 2 we will fabricate trilayers cuprate heterostructures with different twist angle symmetries where the topological gap is amplified and timereversal symmetry broken states appear across a wide range of angles 3 we will create a heterostructure between a superconducting cuprate twisted heterostructure and a topological insulating crystal allowing us to create a chiral majorana edge mode at the end of this project we will have provided a brandnew solidstate tool for emerging quantum technologies in computation metrology secure communication singlephoton imaging methodologies for the entire field of 2d materials and a comprehensive understanding of the governing principles and ingredients for topological superconductivity at high temperatures
ice shelf damage characterization and monitoring around antarctica

the ice shelves of antarctica act as giant dams limiting ice flow from the interior into the ocean recently several of these dams have shown dramatic signs of damage once the ice is fracturing the dam is weakened allowing the ice to flow faster and increasing mass loss from the interior of the ice sheet which results in an accelerated contribution to sealevel as antarctica is the largest reservoir of fresh water correctly predicting its evolution is crucial to anticipate when and how much sealevel will rise damage is currently absent from projection of antarctica evolution because of the difficulty of representing this process in numerical models as well as the lack of observation to constrain them the aim of the icedam project is to quantify and understand the evolution of damage on ice shelves around antarctica my team and i will first use a novel approach based on deep learning to automatically identify the evolution of fractures and their characteristics on satellite imagery by combining this record with inversions from a highorder ice flow model we will quantify the links between fractures and changes in ice rigidity which controls the strength of ice shelves to better understand the damage variability we will measure the evolution of key variables that positively impact the rheological weakening of ice shelves these time series will be analyzed in a unique fashion to determine the major processes that led to the evolution of damage in the satellite observation era based on these results we will set up the first sentinel of ice shelves by systematically mapping the evolution of fractures in near real time this will be used to establish new vulnerability indices based on changes in ice rigidity and their impact on glacier mass balance this project will open a new window on the processes affecting ice shelves at an unprecedented level of resolution ultimately allowing us to improve our ability to predict the fate of sea level rise
holistic framework for the maturity evaluation of readiness level for security technologies

in the recent years there are plenty of metrics that try to evaluate the maturity of productssystemsprocesses when identifying their deployment readiness even though an excessive effort has been made to integrate widely used frameworks methodologies and indicators in the productssystemsprocesses this leads to a limited usage from the eu funded security ri projects as a result a robust scaling framework is more than of utmost importance the proposed multirate scaling framework will rely on the existing established readiness level approaches and will formally combine them into one acceptable and reliable framework multirate will be able to evaluate and apply the readiness of all aspects of productssystemsprocesses it will make a thorough research on the existing methodologies and will develop a wellestablished scale taking into consideration several areas of knowledge such as technology readiness level trl scale integration readiness level irl commercialisation readiness level crl manufacturing readiness levels mrl security privacy and ethics readiness level sprl and societal readiness level srl these rls will set the basis for the creation of the holistic multirate framework that will evaluate the readiness of all aspects of a productsystemprocess the experience gained from previously proposed and ongoing maturity evaluation solutions developed and will be proposed under eufunded projects will lead to the multirate robust holistic framework solution of great importance will be the establishment of a network of projects and organisations that will support the design of the appropriate evaluation methodologies adding also their knowledge and expertise on the calibration and testing of both individual rls and the holistic one this network will be built based on the partners involvement on existing networks and eu funded projects