Dragon09/odtu_chatbot huggingface dataset:
flowinduced morphology modifications in porous multiscale systems

fluid flows through porous media with morphology modifications are ubiquitous across nature and industry from the melting and refreezing of snow to the migration of carbon dioxide in underground aquifers from phasechange materials in energy storage systems to the formation of sea ice a key property of media experiencing morphology variations is that the modifications of the pore structure relate to the local flow conditions which in turn are affected by the geometry of the porous matrix despite their importance and pervasiveness measuring and modelling flow transport and medium evolution in these systems remains challenging due to the multiway coupling multiscale nature and feedback mechanisms the objective of this project is to shed new light on the evolution of porous multiscale systems characterised by flowinduced morphology modifications three classes of media with increasing levels of complexity porous media with phasechange reactive media and reactive media with phasechange will be investigated in welldefined and controlled flow configurations to tackle these problems we will employ in a complementary manner a combination of numerical simulations laboratory experiments and theoretical modelling we will use these findings in a multiscale modelling framework where the largescale and longterm flow behaviour is predicted by simple models that are fed with the results of highresolution numerical and laboratory experiments this project aims at a true scientific breakthrough we want to gain a quantitative understanding of flow transport and medium evolution in porous media with morphology modifications unraveling a number of physical mechanisms that will allow the prediction and control of these complex systems
past to future towards fully paleoinformed future climate projections

the project pasttofuture p2f aims at radically advancing our knowledge of past climatic conditions to better understand earths climate response to different kinds of forcing with considerable focus on potential abrupt climatic transitions and the crossing of tipping points to this end p2f will integrate information from paleoenvironmental proxy data from earth system models esms and from rigorous theoretical approaches being able to reconstruct past climate evolution is a necessary step for enhancing our capacity to look into the future and therefore extensive improvements of stateoftheart esms are needed so far esms are mainly calibrated and validated with respect to the instrumental records of the last 170 years of relatively stable climate while the earths longerterm history is characterised by an interplay of gradual climate change variability and critical transitions between competing states with profound impacts on climate subsystems ecosystems and civilisations understanding the leading dynamical processes and feedbacks and in particular improving our ability to model and anticipate critical transitions in the climate and ecosystems is key to project future climate change on spatiotemporal scales relevant for societies ecosystems and the planet in this context p2f will critically advance our ability to understand and anticipate the main climatic and societal impacts of the ongoing climate crisis specifically p2f will extend the reach of earth system models and demonstrate a step change in the model development cycle of the climate model intercomparison project cmip by providing fully paleoinformed models for future projection and producing a portfolio of plausible future climate change scenarios that are constrained by documented past climate changes and abrupt transitions finally p2f will efficiently disseminate research outputs and engage key stakeholders in dialogue to ensure appropriate synergies are at attained
the most important think tank youve never heard of resources for the future and the history of economic thought in environmental practice

the proposed project will undertake an historical analysis of the development role and impact of the washington dc based think tank resources for the future rff from its founding in 1952 to the late 1990s refuture investigates rffs role in constructing an economic vision of the environment around the concepts of scarcity value and externalities and the subsequent application of that vision through us and international policies focused on managing the environment in relation to economic efficiency by focusing on this history of economic thought in environmental practice refuture raises larger political economic questions regarding the contribution of rff to i the global great acceleration of the anthropocene in terms of material throughput and pollution concomitant with an emphasis on economic growth from the middle of the twentieth century ii what i call here the great deceleration of effective environmental and climate policy from the early 1980s on due to the overwhelming political focus on maintaining economic growth by governing nature and managing environmental impacts through the price mechanism drawing from the methodologies of intellectual history economic sociology and historical political economy i will undertake research at a number of key libraries and archives in the us and will significantly benefit from outbound placements and training at the center for the history of political economy hope at duke university and the institute at brown for environment and society ibes at brown university overall research direction will greatly benefit from a placement at the institute of environmental science and technology icta at universitat autnoma de barcelona a key european centre for research and critical analysis into the relationship between economic growth and environmental sustainability as an affiliated researcher here i will bring key insights from historical analysis of the applied economics of the environment
the multitudes of mosquito viruses and their impact on arbovirus disease ecology

the mosquito virome constitutes not only human pathogenic arthropodborne viruses arboviruses but also mosquitospecific viruses whose host range is restricted to the mosquito while metagenomics studies have revealed the mosquito virome to be richly diverse and abundant our knowledge of these viruses is mostly limited to genome sequence information and we have little insight into their biology and interactions with the mosquito host importantly the cellular and immunological mechanisms by which mosquitoes deal with multitudes of concurrent viral infections remain to be understood furthermore mosquitospecific viruses have been reported to inhibit or enhance coinfecting arboviruses leading to substantial interest in leveraging these viruses as a tool to influence the transmission of deadly human pathogenic arboviruses such as dengue virus through multitudes i will take the first steps in exploring the fundamental biology and ecology of mosquitospecific viruses and their virushost interactions using established techniques from classical medical entomology to omics approaches my hypothesisdriven aims are to 1 characterise the biological properties of mosquitospecific viruses 2 investigate the heritability and fitness cost of mosquitospecific viruses and 3 examine the metabolic interactions between mosquitospecific viruses arboviruses and mosquito hosts given that mosquitospecific viruses are an inextricable part of arbovirus disease ecology the insights revealed during this project will contribute towards a deeper understanding of mosquitoborne disease transmission under the one health concept as such the knowledge generated has the potential to identify opportunities for improved arbovirus transmission risk mapping and for the future development of virome modificationbased biological control interventions against arbovirus transmission
reliable biometric technologies to assist police authorities in combating terrorism and organized crime

tensor will provide leas a platform that facilitates the biometric evidence extraction sharing and storage in cross border environments allowing them to share best practices in an automated robust secure privacypreserving and scalable manner in addition the full potential of biometrics technologies will be exploited and their fusion in case of partial evidence gathered in the crime scenes by forensic institutes strengthening their acceptance in the court of justice more particularly tensor will equip security practitioners with novel tools focusing on a extraction of biometrics and other more or less distinctive features validated in forensic conditions that assist leas in identification identity verification intelligence and investigation processes and can be leveraged to unlock criminals mobile devices b sharing of biometrics through secure automated scalable exchange of biometric intelligence and courtproof evidence among leas in a crossborder manner enhancing interoperability among legacy systems owned by security practitioners and forensic institutes and c storage of biometrics in a privacypreserving way through a biometric data protection mechanism enabling revocability of biometric templates tensor will also introduce the oneofitskind european biometric data space creating a common ground among leas forensic institutes and security researchers assisting in the faster adoption of modern biometric solutions
internal state drivers of behavioral flexibility and their underlying neural circuitry in the zona incerta

survival requires accurate and rapid implementation of adaptive behavior in a world where our physiological needs and surrounding environment are ever changing one wrong move could make the difference between life and death how does the brain successfully compute changes in internal state and external cues while factoring in experience to drive the most appropriate behavioral outcome from momenttomoment mounting evidence suggests that the zona incerta a little studied region is a central switchboard for such adaptive behavior this subthalamic nucleus has widespread connections and was recently found to regulate an astounding range of behaviors critical for survival including defense sleep feeding and much more it also encodes associated changes in internal states such as anxiety fatigue and hunger and integrates sensory inputs across modalities these features suggest that a central function of the zona incerta might be to locally compute needed transitions in behavior based on internal state changes which are then broadcast to downstream targets to convert this into action to address this hypothesis certastates will employ cuttingedge molecular circuit tracing recording and in vivo imaging technologies in mice together with diverse behavioral paradigms and rich behavioral state readouts the ultimate objective is to uncover how distinct internal state changes i are processed in defined cell types and circuits ii drive behavioral flexibility and iii are influenced by deep brain stimulation motivated by the fact that the zona incerta is one of few established targets in humans for this therapeutic approach together this work will advance our understanding of how neural circuits generate internal states and in turn process broadcast and use this information to guide adaptive behavior moreover it will open an entry point for translation by exploring how clinicallyapplied neuromodulation can transform these vital computations
resolving temporal immune responses of arabidopsis roots to infection by fusarium oxysporum at the singlecell level

pathogencaused diseases represent one of the biggest problems in agriculture a detailed mechanistic understanding of plant defenses against pathogenic invasion and disease progression is therefore a vital research topic forming the foundation for the creation of more resistant crop varieties however at present most studies aimed at this utilize omics approaches or mutant analyses which lack resolution and only allow limited understanding of plantpathogen interactions at the singlecell level thus our current models of plantpathogen interaction do not include strictly local or temporal responses the aim of this proposal is to address this with a pathosystem consisting of the model plant arabidopsis thaliana and strains of fusarium oxysporum a destructive fungal pathogen of several food crops a unique nearnative imaging setup enabling the simultaneous study of growth and infection of plant and fungus with singlecell resolution will be used the work in this proposal will probe the responses of individual plant cells to both pathogenic and beneficial f oxysporum strains in a native tissue context from the onset of invasion to full disease development this will generate novel insights into cellular mechanisms employed by plants to fight off pathogenic invaders while accommodating beneficial endophytes by using a novel in vivo celllabeling technique exploiting the fungal avirulence effector secretion system a singlecell transcriptome atlas exclusively of cells undergoing acute colonization will be generated moreover as root barriers represent a physical hindrance for pathogen invasion mutants affected in physical defenses will be tested combined this proposal will expand our current models of immune responses to include specific cells regions or tissues and temporal aspects with high resolution such knowledge is important to develop nextgeneration agricultural tools and will be applicable to combat current and arising diseases
new science in radio astronomy applying cuttingedge technology to enhance the entire data chain from receiver to final output

the goal of the radioblocks project is to achieve a maximal boost for the european major worldleading research infrastructures in radio astronomy which over the years have invested heavily in maintaining existing facilities as well as in substantial upgrade programmes after identifying common challenges towards their mid and longterm scientific visions in this project the institutes responsible of these facilities join forces together with partners from industry and academia in order to develop common building blocks for technological solutions beyond stateoftheart that will enable a broad range of new science and enhance european scientific competitiveness they share the need to continuously improve their capabilities in order to enable new science sensitivity field of view bandwidth angular time and frequency resolution commensality and onsky time reaction time and rfi mitigation engagement with industry to codevelop advanced technologies will increase the partners technological levels and strengthen their market positions creating a true european innovation system this project carries out carefully targeted development work and addresses common aspects in the complete data chain categorizing this in four phases novel detectors and components digital receivers transport and correlator and data postprocessing we will design and demonstrate common building blocks based on cuttingedge technologies that will be enablers and extenders in the areas most critical to the ris and can and will be used for upgrades of several ris the building blocks will be new instrument components and advanced digital solutions based on newly available hpcai optimized hardware this approach will enable a tremendous increase of the science delivery potential of europes major radio astronomical observatories for science cases that are high on their longterm agendas aimed at the widest possible science community in europe and beyond
a newly identified cilium in meiosis deciphering the principles and mechanisms of the zygotene cilium

a hallmark of meiosis is chromosomal pairing which for decades has been a major focus in the field however the nuclear events of meiosis occur in the cellular context of a differentiating gamete and pairing depends on cytoplasmic counterparts by mechanisms that are conserved from yeast to mammals these are essential for fertility but how cytoplasmic counterparts of chromosomal pairing are regulated has remained enigmatic we uncovered a previously unrecognized cilium in meiosis the zygotene cilium in both males and females and in zebrafish and the mouse which completes the mechanical cytoplasmic pairing machinery and extracellularly extend between oocytes within a conserved cellular hub called the germline cyst we established the groundbreaking observations that the cilium is essential for chromosomal pairing prophase progression and cyst morphogenesis ovary development and fertility these uncover the novel concept of a cilium as a critical player in meiosis propose a cellular paradigm that cilia can control chromosomal dynamics and shed new light on reproduction phenotypes in human ciliopathies the zygotene cilium now allows us to zoomout from the nuclear events of prophase to the complete cellular and developmental program of meiosis utilizing our holistic morphological approach invivo zygociliaact will ambitiously achieve this goal in three related but independent aims we will uncover zygotene cilium functional mechanical and regulatory components aim 1 decipher the ciliary developmental signals that govern meiotic prophase progression and cyst morphogenesis aim 2 and expand our findings to investigation in testes as well as use zebrafish as a new model to decipher mechanisms of human ciliopathic proteins aim 3 with zygociliaact we are finally poised to break new grounds in unraveling longsoughtafter fundamental questions cell developmental cilia and reproductive biology and advance reproduction and ciliopathy medicine
geometry dynamics and singularities in fluid flows

the gdsflows project aims to reshape the mathematics we use to understand fluid flows more precisely the goal is to develop completely new tools at the crossroads of differential topology harmonic analysis and dynamical systems to address two of the most pressing problems on the pdes of incompressible fluids 1 if and how do solutions blowup that is after a smooth start do the physical magnitudes of the problem become irregular in finite time and 2 when solutions do not blowup what are the qualitative dynamics attractors equilibrium solutions of the trajectories in the phase space that is in the space of velocity or vorticity fieldsthe project proposes 3 horizons 1 extending the recently obtained universality results for the euler equation on certain riemannian manifolds to the case of pdes modelling the evolution of fluid interfaces where the existence of solutions blowingup in finite time is rigurously known 2 proving that the euler equations on highdimensional euclidean spaces are universal and using this to study whether solutions in very high dimensions that blowup in finite time exist 3 proving the existence of chaotic invariant sets in the infinite dimensional phase space of the 2d euler equation the gdsflows project will be carried out by the researcher an expert in the study of geometric properties of pdes coming from mathematical physics and hydrodynamics he recently developed a method for embedding any finitedimensional dynamical system into the euler equation on certain highdimensional riemannian manifolds building on t taos recent program to prove blowup of solutions to the highdimensional euler equation the researcher will collaborate with the supervisor a prominent expert in the formation of singularities in the pdes of fluid dynamics and one of the authors of the first rigurous proof of blowup in wellposed pdes modelling incompressible fluids
role of the neuroendocrine axis and its link with obesity in the genesis of pcos

polycystic ovary syndrome pcos is a human hormonal disorder of complex etiology characterized by reproductive endocrine and metabolic abnormalities which affects 15 of women of reproductive age and has a very low survival rate recent studies on its pathophysiology suggest that it reflects alterations in homeostatic feedback mechanisms between the ovaries adipose tissue and hypothalamic circuits that develop during embryogenesis despite its high prevalence and significant impact on health there are no effective treatments for pcos due to its complex etiology the development of new animal models displaying features of human pcos is an unmet need because classical mouse models of pcos have relied on its induction with androgen excess providing only very limited insight into the pathogenesis of pcos in a genetic screen against secretable and transmembrane proteins involved in tissuetotissue communication the host lab has identified new genes that act as sensors of the amount of body fat in the larval prothoracic endocrine gland of drosophila this gland corresponds to the neurosecretory part of the mammalian hypothalamus and mutants in these genes are characterized by pcos the main objective of this proposal is to characterize how cell communication in the neuroendocrineadipose tissueovary axis is responsible for the uncontrolled proliferation of gonadal germ cells the underlying pcos will be studied using singlecell genomic approaches metabolomics and genetic studies on the different elements that make up this axis by elucidating the molecularhormonal mechanisms involved in brainadipose tissueovary communication in normal development and disease i hope to better define the pathogenesis and development of targeted therapies against pcos
advanced multimodal marketplace for low emission and energy transportation

freight transportation is responsible for large share of total ghg emissions in europe so far majority of companies have concentrated on their primary emissions and those caused by their energy use while indirect emissions from eg logistics services have received limited attention it is obvious that a systemic sociotechnical change is vital the business models for sustainable sourcing and offering multimodal lowemission transport chains are missing admiral project aims to have a systemic sociotechnical approach the vision of admiral is to change the mindset to take the emission level minimization as the main target by providing tools for companies the main result is the admiral marketplace which manages the whole supply chain infrastructure and related emissions it also works as a channel for developers to distribute innovative and sustainabilityfocused solutions in eu the marketplace will be demonstrated and piloted by admiral partners in 4 pilots portugalspain sloveniacroatia lithuania and finland admiral is focusing on the following objectives 1 evolve seamless operation within supply chains 2 enable better utilization of current assets and infrastructure to decrease emissions 3 embrace systemic change towards sustainability with sustainable sourcing 4 develop and pilot solutions that have altogether energy and emission reduction potential the marketplace will also work as an innovation platform for new services as software and solution developers have clear guidelines to include the invented services to be available in the platform the marketplace will improve the value of the b2b logistic platforms the b2c platforms are dominated by noneu companies eg google but the dominance for b2b platforms is yet to be determined admiral will make contributions to the expected outcomes and impacts of the work programme eg by aiming to reduce emissions more than 20 and improving transparency and resilience