Dragon09/odtu_chatbot huggingface dataset:
volatolomic approaches for improving success rates in assisted reproductive technology

volatolomics has emerged as a new frontier in deciphering unreached matters related with health conditions volatolomics research is based on the study of the volatile compounds emitted by biological samples it was demonstrated that the volatiles emitted though breath skin feces urine or cells can provide useful information for the diagnosis of an important number of diseases such as cancer diabetes or even neurodegenerative disorders we have very recently demonstrated that the embryos do also emit volatiles during their development while genetical disorders alter the pattern of the released volatiles in the present project we aim at assessing volatolomic techniques for the noninvasive assessment of embryos quality in order to select the most viable ones for transfer the ultimate goal of this project is to achieve higher success rates in the in vitro fertilisation
2ps prevent protect through support

the european commissions latest strategy for fighting child sexual abuse highlights a harsh reality that globally we are losing the battle against online child sexual abuse and exploitation ocsea various projects funded through the eu are working diligently to identify the source of csam on both the clearnet and darknet and are establishing stronger awareness of the needs and requirements of leas to fight the overloading volume of images text media files etc however the iocta 2021 report also brings a chilling honesty that the prevalence of materials shows no sign of slowing or stabilising the adage that prevention is better than the cure never seemed more fitting the 2ps project condemns all forms of sexual abuse and exploitation and there are no excuses that justify behaviours and actions that harm or victimise children however to reduce the number of abused children and those at risk of exploitation we need to address various challenges several of those relate to people with a sexual interest in children and their needs to divert them from abusing 2ps which stands for prevent protect through support is a highly innovative action offering a paradigm shift in the approach to tackling child sexual abuse and exploitation csae across europe the highly qualified and diverse consortium together with leading global actors are committed to laying the foundations for new coherent modus operandi that complement the reactive approaches currently favoured this is achieved by addressing the support needs of people with a sexual interest in children and people who feel they might offend we will share the best practices for guidance therapy and treatment methods combined with new training and awareness for frontline support workers and leas we aim to move preventive actions to the forefront offering alternative courses of action to existing offenders and people who fear they might offend including people with a sexual interest in children
curing contaminated and saline land with industrial crops and producing biomass for highvalue applications

iasis aims at providing solutions for curing both contaminated and saline land through phytomanagement selected highyielding nonfood industrial crops will provide biomass feedstock to develop intermediate and end bioproducts following a cascading biorefinery approach via economicviable value chains farmers will have an active role on how to remediate the contaminated andor saline soils while generating additional income by providing sustainable feedstock for nonfood valueadded applications in order for the main and specific objectives to be fulfilled a total number of 6 work packages have been designed the work starts with the crops optimisation improved genotypes and phytomanagement strategies microbial consortia development wp1 for both contaminated and saline soils that will be tested and validated both in lab scale and in field case studies fcss fcss will be set up wp2 in eight sites in europe 4 contaminated and 4 saline where 8 highyielding nonfood industrial crops will be grown following lowinput and phytomanagement practices to produce feedstock for the value chains and the bioproducts development wp3 as well as to engage and train the farming community wp2 two main groups of bioproducts will be developed wp3 based on the type of industrial crops exploited oilseeds and lignocellulosic and in total 10 intermediate and 10 endproducts will be developed and tested sustainability and feasibility assessment will be carried out on the most promising biomasstoproducts pathways wp4 a decision support system to assess the viability and the soil remediation of the proposed value chains and applicable business models will be developed tailored to the iasis needs that will be applied for the iasis case studies but will be applicable beyond the project the regulatory framework will be outlined while policy recommendations will be proposed wps 5 6 are dedicated to project dissemination and coordination
numerical modeling of cardiac electrophysiology at the cellular scale

cardiac function is coordinated by an electric system whose disorders are among the most frequent causes of death and disease numerical models of this complex system are mature and widely used but to match observations in aging and diseased hearts they need to move from a continuum approach to a representation of individual cells and their interconnections this makes the problem more complex harder to solve and four orders of magnitude larger necessitating exascale computersthe eurohpc2019 microcard project is developing a simulation platform that can meet this challenge by a joint effort of hpc experts numerical scientists biomedical engineers and biomedical scientists from academia and industry our proposal is to establish a centre of excellence that will consolidate and scale up the microcard results enabling digital twins of cardiac tissuewith a consortium gathering the core partners of microcard we will further develop microcards numerical schemes moving to secondorder spatial discretization based on microcard results we will develop mixedprecision preconditioners and data compression to reduce communication bandwidth the highly successful efforts towards automated compilation of highlevel model descriptions into optimized energyefficient system code for different cpus and gpus will be extended to upcoming architectures we will continue efforts to robustify parallel remeshing software and add necessary functionality for parallel mesh partitioning and production of realistic synthetic tissue meshes needed for simulationsthe platform will be benchmarked with realistic test cases and be made accessible for a wide range of users with tailored workflowsthe platform will be adaptable to similar biological systems such as nerves and several of our products such as improved solvers preconditioners remeshers and partitioners will be reusable in a wide range of applications
deepinelasticscattering and vectorbosonfusion advances

the large hadron collider lhc probes interactions among particles with unprecedented precision the determination of the higgs boson properties is a central pillar of the lhc physics program and of the current lhc runthis demands for accurate theoretical predictions which usually hinge on monte carlo event generators stateoftheart predictions are given by nexttoleadingorder nlo calculations in qcd matched to leadinglogarithmic ll parton shower ps nexttonlo nnlo matching necessary to advance the accuracy of theoretical predictions is limited to specific processes like the hadroproduction of heavy systems in the final statevector boson fusion vbf is the preferred channel for the determination of the higgs to muon couplings and for higgs to invisible searches this projects aim is to pioneer nnlo matching techniques for processes characterised by the tchannel exchange of a colourless boson such as vbf and vector boson scattering vbs and to develop the first nnlops generator for higgs boson production in vbfgiven the close relationship between higherorder corrections in vbf vbs and deep inelastic scattering dis the initial focus will be the formulation of a nnlops matching scheme for dis this matching will preserve the logarithmic accuracy of both the new nextto ll nll showers and the standard ll ones additionally to achieve this task novel resummed predictions for dis will be produced reaching nnlonll accuracy within a comprehensive ps simulation is a groundbreaking endeavourthese outcomes will be vital for precise studies of the higgs sector in the current and future lhc runs and for highprecision investigations at future distype facilities like the electronion collider furthermore this project will lay the foundations for a more widely applicable nnlops matching approach with superior logarithmic accuracy which can be extended to a broader range of collider processes involving qcd jets
twofaced hopes football migration and religion between west africa and europe

since the 1990s and the commercialization of global football an increasing number of young people in countries like ghana ivory coast and cameroon have aspired to play football as a career a strategy to migrate abroad ideally europe and an opportunity for social and class mobility for the majority however the dream does not come true international media and human rights organizations regularly report about thousands of young west africans victimized by deceitful agents stranded as undocumented migrants and playing for clubs under exploitative conditions and yet young people continue to train to migrate and play scholars have studied these footballrelated migrations but they have overlooked the fact that religions especially pentecostal christianity and islam play a central role in migrants hopeful journeys this project investigates the intersection of football migration and religion among african migrants in europe in order to study hope conceptualized as a belief that something desired may occur in the future it makes a crucial critical intervention while many interdisciplinary studies assume a depoliticized notion of hope and romanticize its positive and constructive qualities janushope also examines the dark side of hope that perpetuates inequality and exploitation it turns to african irregular football migrants in europe to understand how a critique of the global industrys dark side of hope might coexist with hopes for making it in the industry it investigates how their faithbased narratives of hope might both critique and reproduce inequalities of global capitalism and transnational migration the key research methods are semistructured interviews and ethnographic fieldwork with irregular african football migrants in europe the results will be disseminated through refereed articles and communicated to a wide global audience interested in football and to key european policy makers in fields of migration and human rights
personalized adjuvant treatment for hrher2 breast cancer for young patients

worldwide 7 million women live with or beyond breast cancer bc as 10year survival rates exceeding 80 for earlystage iiii bc premenopausal bc accounts for 25 in the eu and 55 in lowmiddle income countries most premenopausal women with bc have high risk of recurrence therefore standard treatment includes adjuvant chemo ct and endocrine therapy et however treatment has substantial physical emotional and social burden which is often more pressing for younger compared to older patientsgeneexpression assays are used for postmenopausal patients to identify women who can safely forego ct without detriment on clinical outcomes preserving quality of life qol however a definitive study has yet to be conducted among premenopausal women with highrisk hrher2bc the primary objective of pathforyoung is to conduct a pragmatic randomized controlled trial rct with 5000 patients validating the use of a geneexpression assay to drive adjuvant treatment decisions in this target populationpathforyoung aims to achieve its objective in 7 years the project i builds on and complements an ongoing twin rct to ensure timely recruitment ii leverages on a large international consortium of oncologists pathologists patient representatives psychologists sociologists ethics and communication experts biostatisticians health economists and technology providers to assure complementary and multidisciplinary expertise and iii highlights patientengagement participatory care and early involvement of end users pathforyoung will also study implementation of digital selfmanagement to support patients throughout the cancer journey and particularly while on et to improve qol and medication adherence a full hta will ensure a path towards crosscountry implementationpathforyoung has the ambition to improve bc care fully integrating the predictive personalized preventive and participatory principles of health management
supplementum creticum new inscriptions from crete

new investigations of the inscriptions from crete are highly desirable and expected by historians and epigraphists of ancient greece the inscriptiones creticae icret vol iiv published by m guarducci between 1935 and 1950 lacks both of the fifth volume which should have been devoted to the inscriptions of cretan localities that are no longer identifiable and of a supplement on inscriptions discovered in the last 90 years many of the 15 geographical corpora included in the inscriptiones graecae ig the most important project on greek epigraphy such as those from attica or boeotia received an update after many decades because icret was independently published crete was not a priority for ig and an update dedicated to the cretan inscriptions never appeared therefore a new edition of all inscriptions from crete is strongly needed but it is beyond the possibilities of a single scholar requiring a very long time excluding the reedition of those inscriptions already collected in icret the proposed project is consistent with the time scale of a msca and would be beneficial to several disciplines specifically it aims at providingi a corpus of the cretan inscriptions not included in icret a broad scientific impact can be expected as this corpus will be in synergy with icret and with findings from other fields eg prosopographyii an open access digital database to make the result easily accessiblethis digital database will help in improving the most popular open access epigraphic publishing projects for greek inscriptions the openaccess database of epigraphic material will also be made palatable to a broader public accompanying the collected inscriptions with photos english translations commentary etc following the epigraphic tradition a book edition in latin will be printed addressed to a specialised audience gender social and environmental aspects although not central to the project are taken into account
highly efficient heavy metalfree color conversion ink technology for microled applications

qustomdot is the first and only company developing an allaround heavy metalfree quantum dot qd solution which is fully rohscompliant while combining high stability under high light flux with the excellent optical properties required by the microled applications this is an urgent demand from the display industry which cannot develop marketable microled displays without using an efficient qd color conversion technology qdcc free of heavy metalsour main target customers are the microled developersmanufacturers while the users are panel makers oems and the end user we are already collaborating with key players from all the layers of the value chain and we have 6 patent families 3 of them already grantedour unique capacity as key enablers of the microled technology will position us as the reference on qdcc for the nextgeneration display technology our vision is to become a world leader in the qd quantum dot market addressing a 20 of the market share by 2030
hoverflies as a new class of managed pollinators for better quantitative and qualitative yields of vegetable fruit and seed crops

polyfly produces and commercializes alternative natural pollination solutions for seed production and protected cropping based on a group of highly efficient pollinators syrphid flies also known as hoverflies flower flies our offering includes 2 new pollinators1 goldfly gf eristalinus aeneus is well adapted to hot and sunny conditions such as those encountered in the mediterranean basin 1440c2 queenfly qf eristalis tenax is better adapted to the cloudy and cooler conditions characterizing continental and oceanic climates of northern europe or spring and autumn seasons 1030cboth are common and widespread species e tenax is considered cosmopolitan and they are excellent pollinators as they exhibit a strong floral foraging behaviour similar to the one of bees like them they continuously visit flowers to feed on pollen and nectar sources of proteins and carbohydrates necessary for their development and survival
trustworthy ai tools for personalized oncology

modern machine learning algorithms have the potential to accelerate personalized medicine in a fast pace to date first tasks in medicine are being addressed with machine learning algorithms that surpass humans in terms of accuracy and speed including diagnosis outcome prediction and treatment recommendation however for a widespread adoption in clinical practice a good performance in terms of speed and accuracy is not sufficient practitioners also need to be able to trust a models prediction in all stages of its life cyclei will facilitate an efficient interaction of clinicians with ai models by developing trustworthy ai tools for personalized oncology first i will develop trustworthy ai tools and algorithms for diagnosis and stratification of cancer patients second i will establish a framework for reliable and transparent modelling of personalized outcomes and therapy decisions in oncologytaipo will result in novel algorithms and software tools for quantifying and improving the trustworthiness of ai models that i will apply to three clinical applications i trustworthy aibased skin lesion classification based on dermoscopic images ii stratification and personalized outcome modelling for patients with acute myeloid leukaemia aml based on omics data and iv therapy recommendation for metastatic breast cancer patients based on electronic health recordstaipo will increase the throughput of trustworthy diagnoses of skin lesions and pave the way for lowcost access to diagnostic care it will empower clinicians to make personalized and reliable therapy decisions which we will demonstrate at the example of aml and metastatic breast cancer our novel algorithms to evaluate and improve the reliability of ai models are a crucial contribution to close the gap between insilico aibench and bedside and will further push the field of trustworthy machine learning with many applications of ai in medicine
improving bioproduction through dynamic regulation circuits

biological production of chemicals and materials is a renewable and economically viable alternative to the current chemical processes easing the transition towards a biologybased circular economy the current biomanufacturing industry faces a scalability problem frequently producer strains created in the laboratory do not respond well to industrial conditions eg large fermentation volumes accumulation of toxic intermediates media acidification etc the goal of biocircus is to address the issue caused by the lack of robustness of the engineered microbial strains biocircus is based on three main research pillars 1 the construction of biosensor and dynamic regulation circuits that measure and control the production of the target molecule 2 the use of machine learning predictive models and automation to improve these circuits and 3 validating the designed strains in preindustrial conditions closer than standard molecular biology laboratory procedures to realworld bioproduction operations naringenin a key molecule of the flavonoid family will be used in as proofofprinciple molecule e coli will be used as model organism the design and construction of biosensors and dynamic regulation circuits controlling naringenin production is expected to support the development of methodologies and tools suitable for any other detectable metabolite biocircus will produce academic and industrial impacts that will boost the bioproduction field by enabling a shorter strain timetomarket for a wide variety of adaptive and scalable microbial bioproducer strains
development of a marketable adjuvant candidate for vaccine applications

adjuvaccine seeks to leverage a breakthrough made in the erc2016stg716878 project to validate a synthetic technological platform for the scalable production of identified optimised saponin adjuvants for improved costeffective vaccines we have developed in the laboratory potent safe stable and streamlined adjuvant leads that surpass the qs21 natural product adjuvant leading to patent applications and the interest of pharma in this poc project we aim to exploit our synthetic saponin technology to produce adjuvantvaccine candidates at scale that outperform existing products more costeffectively lowering the risk profile of the commercialisation potential while also achieving valorisation outcomes for market entry the goal is to demonstrate the scalability of our innovative adjuvant technology and select an optimal adjuvant candidate in advanced preclinical settings for entering the vaccine market via spinoff formation following proper ipr strategy implementation and attraction of key investorspartnersthe breakthrough innovation potential of adjuvaccine lies in the exploitation of this adjuvant platform for largescale production and selection of the best candidate lead for application in vaccines against various diseases improving the available vaccine solutions the high purity and excellent chemical control of our synthetic technology versus the heterogeneous natural product adjuvants as well as its streamlined scalable nature and lowcost profile are unique attributes of our platform that will be valorised herein making it a potentially superior alternative to existing vaccine models with less structural definition and costlier timelines the main objectives are 1 demonstrate our synthetic technology platform for the gramscale production and selection of a candidate adjuvant lead and 2 implement valorisation opportunities and verify the potential of spinoff creation by establishing an optimal ipr and publicprivate funding roadmap plan
amazing largescale trials and pilots for verticals in 6g

amazing6g proposes a novel set of 14 use cases in the domains of healthcare public safety energy and transport including rail which will be showcased in largescale trials and pilots across europe innovative technology enablers are planned to be developed and tested in the areas of communications computeasaservice applications and ai iot and localization security aspects will be taken into consideration in the development of solutions framed in this context the significance of largescale trials in b5g6g networks lies not only in their ability to validate the technical capabilities of the technology but also in their capacity to unveil new use cases and applications that were previously inconceivable as we move towards a world where the internet of things iot augmented reality and artificial intelligence play central roles in our daily lives these trials provide a unique opportunity to explore the potential of b5g6g in fostering innovative solutions across various sectors from healthcare and transportation to utilities and publicenvironment safety through largescale trials stakeholders can gain valuable insights into the transformative power of b5g6g networks and strategically position themselves to harness the full spectrum of opportunities that this cuttingedge technology offers