Dragon09/odtu_chatbot huggingface dataset:
open universal science

the open and universal science opus project will develop coordination and support measures to reform the assessment of research and researchers at research performing organisations rpos and research funding organisations rfos towards a system that incentivises and rewards researchers to practise open sciencewe understand the term open science to refer to practices providing open access to research outputs early and open sharing of research participation in open peerreview measures to ensure reproducibility of results involving all stakeholders in cocreation we henceforth in this proposal employ this interpretation of open science with a specific focus on reforming the researcher assessment system to incentivise and reward researchers to take up these practicesopus employs a threetiered approach to ensure representation and consensus building of key stakeholder groups in the open science ecosystem 1 our large project consortium consists of researcher organisations rpos rfos industry organisations and experts in project management public relations and open science 2 a series of stakeholder engagement sessions will be held with the broader community to gather input and validate key project deliverables 3 an advisory board of key representatives will ensure expert oversight and links to the communityobjective 1 conduct a comprehensive stateoftheart on existing literature and initiatives for open scienceobjective 2 develop a comprehensive set of interventions to implement open science at rpos and rfosobjective 3 develop realistic indicators and metrics to monitor and drive open science at rpos and rfosobjective 4 test the interventions and indicators and metrics via action plans in pilots at rpos and rfosobjective 5 utilise a stakeholderdriven feedback loop to develop monitor refine and validate actionsobjective 6 synthesise outcomes into policy briefs and a revised oscam2 for researcher assessment
the first heart failure therapy management pointofcare device with multiplex and multimodal sensor

cardiocap is the first ever multiplex and multimodal pointofcare poc device used for heart failure hf therapy management with just a prick on the patients finger and a drop of blood healthcare professionals can deduce the severity of the hf patients conditions through simultaneous detection of 4 blood biomarkers namely potassium sodium creatinine and ntprobnp with the comprehensive data generated by the 4 biomarkers they can make prompt and informed decisions on the appropriate treatment by optimising the drug dosage or exploring other treatment options they can prevent patients entering acute decompensation events or adverse side effects such as kidney failurecardiocap is a handheld poc device that works with a drop of blood from the prick of a finger and is as userfriendly as a glucometer it performs at the same standard as the gold benchmarks ie the stratus cs by siemens cobas cardiac ntprobnp by roche and standard laboratory testing but is used after patients are discharged from hospitals with cardiocap continuum care for hf patients is made available after hospital discharge at the patients home community care centres neighbourhood clinics and pharmacies rehospitalisation rate and mortality rate is expected to be reduced by at least 30 furthermore it helps to free up the hospital capacity for other emergency cases that could not be prevented this mission is aligned with the health inequality gap in the eu with the world economic forum wef stating that ill health accounts for 20 of total healthcare cost in closing the health inequality gap the wef urged for health initiatives such as poc that enable people to receive the health services they need
geodesic currents and geometric structures

this project will study the intrinsic geometry of the space of geodesic currents of a hyperbolic surface a suitable closure of the space of weighted closed curves containing many geometric structures this space has been crucial in many technical developments in the field of hyperbolic geometry bersteichmueller theory and the geometry of 3manifolds recently it has permeated into other fields of mathematics such as compactifications of character varieties or geometric group theorythe goal of the project is to further these applications and unveil new connections with physics in the setting of conformal field theories
reducing nonhuman primates in nonclinical safety assessment the european initiative on minipig and micropig models

nhpig is an innovative health initiative ihi project based on the publicprivate partnership of the european union and europes health industries its objective is to expand share and implement biological knowledge of minimicropig models with the aim to reduce nonhuman primates nhps in nonclinical safety studies the transnational consortium includes experts in porcine medical models veterinary pathology computational animal science nonclinical science omics profiling new approach methods nams as well as bioinformatics and artificial intelligence nhpig will i characterise humanised minipigs micropigs and tailored disease models including systematic biobanking multiomics profiling and stateoftheart imaging modalities ii develop validate and implement biosensors medical devices and intelligent animal housing for automated data collection and analysis in minipig safety studies iii fill significant knowledge gaps in the pathophysiology of the porcine immune system iv validate known toxicity and efficacy biomarkers and discover novel biomarker candidates for nonclinical safety assessment v overcome the shortage of laboratory tools and reagents such as validated antibodies vi gain experience in using minimicropigs for safety testing of biologicals and new therapeutic modalities vii investigate in vitro to in vivo extrapolation of liver and kidney toxicity in pigs and nhphumans to provide a comparative link to human new approach methodologies nams and viii provide a publicly available database and it platform for compiling integrating and analysing existing data in nhpshumans with data in minimicropig models existing data and data generated within the nhpig programme the establishment of a regulatory advisory board and an ethics and animal welfare advisory board will expedite regulatory interactions and ensure compliance with the 3r principles nhpig will generate the scientific basis for deselection of nhps in nonclinical safety assessment which is an ethical requirement and also imperative according to eu legislation
smart dismantling sorting and recycling of glass fibre reinforced composite from wind power sector through holistic approach

refresh aims to develop and demonstrate a novel circular smart system for an improved recycling 90 of glass fiberreinforced composites derived from wind turbine dismantling or reblading with high purity level the project will focus on the mechanical and thermal treatment of waste but it will strongly involve the entire reverse circular value chain from endoflife blades to a wide range of remanufactured products refresh proposes a flexible remanufacturing line when a windblade is decommissioned it will be performed a selection of optimal recycling process according to the technical condition of the blade and current market demand this will be achieved by using a dedicated tracking tool for collecting protecting and sharing information and an embedded decisionmaking tool software for selecting time by time the most sustainable approach to recycling the project will focus on the most robust and mature mechanical treatments where composites are grinded in various size and used as new raw material to create multifunctional panels for automotive marine applications home furniture civil construction the project will design and deploy an upscaled process starting from the already available remanufacturing line of gees recycling aviano italy another robust and proven process is the thermal technology here proposed by gjenkraft that allow also to recover long and clean fibers without matrix having properties comparable with the one of virgin fibers the holistic approach developed within the project will be validated by means of lcalcchealthsafety analysis the project will finally contribute to the increase of awareness among stakeholder communities through direct engagement aimed at replicating the solution in europe and guarantee a capillary presence of treatment plants the novel refresh approach will allow potential savings of virgin raw materials of 22 and 52 mton after 5 and 8 years from project end respectively
bioplastics and plastic additives as emerging environmental pollutants on a marine key species gilthead sea bream

biodegradable plastic bp has been proposed to replace traditional plastic consequently their production has exponentially increased nowadays aquatic fauna is exposed to chronic low doses of complex mixtures of chemicals among them plastic additives released from plastic items however a fundamental gap of knowledge exists about the effects of bps and associated additive plastic mixtures in early development this represents an important environmental and health problem because until it is filled toxicological threats remain ambiguous the goal of biobream is to assess the implications of switching from legacy plastic to alternative bps on key marine species for that we will use the early stages of a commonly farmed species in the mediterranean gilthead sea bream a comprehensive program consisting of 3 independent yet complementary work packages will assess the impacts of bps and their additives on fish physiology transcriptomic and epigenetic responses these data will provide key insights into the mode of action of these new compounds and a mixture of plastic additives then we aim to elucidate and further validate new biomarkers for aquatic pollution on marine fauna together with the vast experience of the host pi dr sole and her previous data we expect to integrate all the results to build a qualitative adverse outcome pathway the multidisciplinary team at icmcsic and the advisory board will ensure the successful achievement of the proposed goals with close supervision of the progress of the project the project will be complemented with a placement at placton for advanced training in outreach a local company devoted to communication and environmental education related to the marine environment biobream is significant because it is expected to fill the gap of bp and mixture impacts on a marine key component of the trophic chain with interest in aquaculture this will consolidate the applicant as a promising earlycareer researcher
understanding the biophysical embryouterine interactions during implantation

the proposed research aims to understand biophysical embryouterine interactions during periimplantation to identify factors that guide processes such as embryo orientation egg cylinder morphogenesis and embryonic axis formation recent studies on implantation have gone beyond the traditional biochemical approach to reveal that mechanical interactions at the embryouterine interface are abundant and indispensable for proper implantation and development due to difficulties in recreating embryo implantation exvivo setups and lack of inutero accessibility the physical forces and mechanochemical feedbacks involved in embryo implantation however still remain unknown in this proposal i will study how mechanical interactions at the embryouterine interface during implantation affect embryo development by directly measuring physical force at the interface identifying the role of major mechanotransducer pathways and making inutero observations in objective 1 i will build an experimental setup with 2d polyacrylamide paa gels of varying mechanical properties to recapitulate the characteristics of the uterine surface in exvivo setups and observe how embryo development depends on the mechanical properties of the substrate in objective 2 i will combine traction force microscopy tfm and live imaging to quantify how physical forces affect molecular and cellular events during the mouse implantation process in objective 3 i will identify how the mechanical forces are transduced into biochemical cues through liveimaging and geneticpharmaceutical perturbations finally i will investigate the implantation process live inutero using multiphoton intravital imaging to validate my findings from exvivo studies i hypothesize that mechanical cues will be spatiotemporally linked with biochemical signaling to significantly affect embryo development
a novel support material for 3d bioprinting and postprinting tissue growth print and grow

threedimensional 3d bioprinting holds great promise for tissue engineering with extrusion bioprinting in suspended hydrogels becoming the leading bioprinting technique in recent years in this method living cells are incorporated within bioinks extruded layer by layer into a granular support material and undergo gelation through diverse crosslinking mechanisms it offers high fidelity and precise fabrication of complex structures based on the living tissue properties however the transition of cell mass mixed with the bioink into functional nativelike tissue requires postprinting cultivation in vitro an oftenoverlooked drawback of 3d bioprinting is the nonuniform shrinkage and deformation of printed constructs during the postprinting tissue maturation period this leads to highlyvariable and unpredictable engineered constructs posing a challenge for the technology to meet applicative requirements we propose to develop a novel technology of print and grow 3d bioprinting into a specially designed microgel aimed to enhance the longterm structural stability of the printed objects by providing structural support and a possibility for live monitoring during tissue maturation our preliminary testing of the print and grow method demonstrated accurate bioprinting with high tissue viability while preserving the construct shape and size unlike current state of the art approaches we aim to optimize the support material properties and develop scalable and reproducible fabrication techniques we also plan to test the print and grow for a wide range of tissue types and adjust the microgel according to specific tissue requirements finally we will study the in vivo transplantation possibility of the tissue generated through the print and grow process the results of our proof of concept project may lead to emergence of universal and userfriendly 3d bioprinting technology for regenerative medicine drug discovery and cultured meat industry
engineering cancer dormancy as a collective emergent phenomenon from matrixenabled dormancy to collective dormancyonachip

cancer dormancy and the trigger to transition to active metastatic growth is a big open question current in vivo models focus on nichespecific cell and molecular mechanisms ignoring biophysical aspects dormancy evolves with complex spatiotemporal dynamics yet there is a knowledge gap in the understanding of the heterogeneity of the units and the dynamics of their interaction and evolution emergence occurs when a critical mass of units synergistically communicates giving rise to a new macrolevel organization with properties greater than the sum of the units engineering emergent phenomena in biological systems is a big research challenge as they originate from multiscale communication in dormatrix i propose a radically new view i hypothesize that the balance between cancer dormancy and awakening is a collective emergent phenomenon whereby a critical mass of microunits communicates with each other and the environment in order to transition to metastatic growth the main objective of dormatrix is to engineer breast cancer bc dormancy as a collective emergent phenomenon using biomaterialsbased dormancyonachip devices my previous data shows that we can i apply biophysical cues to control bc proliferation and ii visualize in vivo early bc bone metastasis i will now address this outstanding challenge with a multidisciplinary approach and 1 apply biophysical principles with novel biomaterials to model in vitro cancer microunits 2 develop advanced 3d imaging to visualize collective cancer dormancy and bone microdamage 3 develop in silico models based on evolutionary game theory to predict the dynamics and 4 prove my hypothesis with dormancyonachip devices understanding the critical mass and multiscale communication required for emergent phenomena will enable the development of novel therapies to delay or prevent metastasis the resulting technology for engineering emergent phenomena will spark research on other biological systems
multirecycling strategies of lwr snf focusing on molten salt technology

multirecycling in lwrs is a tangible solution enhancing further the circular economy and moving towards the closure of the fuel cycle however this option presents some limitations related to the degradation of the pu isotopic composition and the generation of minor actinides ma leading to an increase of vitrified highlevel waste when compared to multirecycling with frs thus limiting its benefits from a repository footprint perspectivesignificant improvement in converting all the pu isotopes and ma into fission products with shorter halflives can be achieved with the introduction of advanced reactor systems among which the molten salt reactor msr using chloride salt is particularly promising in this reactor the fuel is a fluid eliminating the major technological bottlenecks of refabrication of solid fuels with high transuranic contentthere is no experience of chloride msrs cl msr in operation but it was studied and tested on experimental setups showing a great improvement in the conversion rate of actinidesfor these reasons mimosa aims to develop an accessible costrisk optimised multirecycling strategy of lwr spent fuels based primarily on multirecycling of pu and repu in lwrs combined with the cl msr and using already available infrastructure in the eu such as the french reprocessing plant not only for its existing lwr fuel treatment capabilities but also for its pu partitioning and waste conditioning capabilities its compatibility with chloride salts and in the future for its potential additional capabilities in ma separation and salt management this strategy will also be compared with other multirecycling scenariosmimosa focus more specifically on the demonstration of several key aspects of technical feasibility and performance of cl msrs that will contribute to accelerating the deployment of this advanced technology on pu and ma conversion respectively and on production of valuable isotopes for other applications
radiative cooling concrete

thanks to miracle project ga 964450 radiative cooling concretes have become a reality different works under the umbrella of miracle have constructed an indepth knowledge on the chemical composition microstructural texture and microadditions required for transforming regular concretes into hightech radiative cooling concretes in fact the miracle partnership has developed and patented a new set of concrete formulations that are capable of operating at subambient temperatures under sun exposure these daytime radiative cooling cementitious composites drccc can revolutionize both modern buildings and our urban landscapewithin this context the present coolcrete proposal aims to explore the commercial possibilities of the developed technology and in particular targets to the following objectiveso1 to assess the possibility of drcccs for being integrated in current cooling and heating technologies and in particular identity the potential synergy with compression heat pumps and thermal energy storage devices o2 to identify geoclimatic scenarios and annual sessions where our drccc can be especially relevant ando3 to identify the most attractive markets and end users for the drccc products these actions together with other complementary activities to be undertaken under the umbrella of other funding agencies are expected to boost the trl and brl of our drcc to a level that can allow us to explore the creation of a spinoff at the beginning of 2025
reengaging with neighbours in a state of war and geopolitical tensions

following the russian invasion of ukraine the eu has responded by reengaging with its neighbours this builds on the assumption that bringing them into the european family of liberal democracies will increase the resilience of the whole european community against external negative interference combining insights from a variety of academic fields reengage will deliver innovative research and concrete advice on how the eu should adapt its foreign policy tools to the current context russias war against ukraine has radically altered european security not only causing extreme civilian suffering in ukraine but posing a direct threat to neighbouring countries fearful of the war spreading confronted by the direst security crisis in decades eu policymakers are forced to fundamentally rethink their security policies europe has demonstrated unexpected unity and resolve adopting a series of sanctions against russia and increasing national defence spending to better handle potential military threats this has also led to a revival of eu enlargement process while this will not improve eu resilience to military threats in the narrow sense it may counter hybrid warfare which is the more likely threat faced by the eu and most of its neighbours the neighbourhood policy and the accession process require urgent adjustment to build strong resilient neighbourhood states capable of countering external threats particularly those posed by hybrid warfare a systematic investigation of how this can be achieved in the current context without compromising the eus values and security is therefore needed since russias annexation of crimea in 2014 there have been increasing calls from the eu for a more contextsensitive approach to its neighbours reengage will assist the eu in determining how best to achieve this goal through an indepth study of six cases three in the western balkans and three in the eastern neighbourhood
singularities and symplectic mapping class groups

symplectic topology is a central part of modern geometry with historical roots in classical mechanics symplectic structures also arise naturally in lowdimensional topology in representation theory in the study of moduli spaces of algebraic varieties and in quantum mechanics a fundamental question is to understand the automorphisms of a symplectic manifold the most natural ones are symplectomorphisms ie diffeomorphisms preserving the symplectic structure i propose to study structural properties of their group of isotopy classes called the symplectic mapping class group smcgin dimension two the smcg agrees with the classical mapping class group in higher dimensions our understanding is very sparce i propose to systematically study smcgs for the family that i believe to be the key building blocks for developing a general theory smoothings ie milnor fibres of isolated singularities i first propose to give complete descriptions of categorical analogues of smcgs for two major complementary families milnor fibres of simple elliptic and cusp singularities project 1 stein varieties associated to twovariable singularities and quivers project 2these capture two different generation paradigms one where the classical story generalises and one for which it systematically breaks this will inform project 3 in which i propose to describe the categorical smcgs of universal milnor fibres introduced here progress on these projects will also bring questions about the dynamics of smcgs within reach for the first time project 4 will study these applications the proposed constructions combine insights from different viewpoints on mirror symmetry with ideas from representation theory and singularity theory and i also plan to apply symplectic ideas to answer classical questions in singularity theory beyond this the proposal borrows ideas from inter alia geometric group theory algebraic geometry and homological stability