Dragon09/odtu_chatbot huggingface dataset:
therapeutic discovery for inflammatory bowel disease

inflammatory bowel disease ibd a major cause of colorectal cancer crc and a huge socioeconomic burden in europe and beyond ibd comprises diseases that are characterized by chronic inflammation in the gastrointestinal tract and includes ulcerative colitis uc and crohns disease cd these diseases are lifelong causing debilitating symptoms and can be lifethreatening ibd is caused by an interplay between the patients genetic predisposition immune responses and environmental factors chronic inflammation with fibrosis is the key driver of disease complications such as stenosis abscess formation and colon cancer ibd affects about 32 million people in europe ibd patients have an increased risk of crc caused mainly by chronic intestinal inflammation leading to proneoplastic effects in fact ibd patients have an alarming 2 to 5 fold increased risk of developing crc compared to the general population despite many treatment options there is no cure for ibd the ibd health economic burden in europe is high and estimated at over 5b year it is widely accepted that to overcome the challenges and to break through the therapeutic ceiling combination therapies or completely novel approaches will be needed due to the increasing incidence and prevalence and associated burden of ibd the lack of effective longterm treatment options and the associated risks including crc ibd remains an important unmet medical need with an urgent need for novel therapies that can improve patient outcome here we will explore the use of a completely novel class of molecules exploiting a unique firstinclass mechanismofaction and validate their efficacy as a therapeutic for ibd proofofconcept studies will be performed in stateoftheart mouse models the data obtained will represent a robust data package towards ind for this indication we propose a novel therapeutic option for ibd that has the potential to address this important unmet medical need
citiobs enhancing citizen observatories for healthy sustainable resilient and inclusive cities

citiobs will consolidate and apply tools and practicebased knowledge for cocreating data knowledge and local action via citizen observatories cos these tools will enhance existing and new citizen observatories to engage citizens and marginalised communities add value to environmental observations in the urban context increase and validate citizen observations of the urban environment as part of the existing insitu earth observation systems cocreate inclusive local actions for sustainability and ensure that co data contributes to research and policy development towards the objectives of the european green deal to ensure broad use the citiobs tools and approaches will be developed in cocreation with cos in 5 frontrunner cities finetuned with 30 implementer cities and showcased to 50 fellow citiesthe pressure on cities to speed up the process of emissions reduction from pollutants and climate gases is overwhelming the required measures are likely to be found not only in technological development but also in the required social transformations theseis transformations includes increasing citizen involvement and engagement with science and policy increasing awareness of the underlying issues and promoting societal actions to protect the urban environment technological innovations need to be considered within the context of multilevel vertical and horizontal governance structures where citizen participation is recognized and included citiobs will support citizen observatories in distinct cities to createenhanceor scale up inclusive and diverse citizen observatories fostering in particular an active role of citizens in the observation of the urban environment using lowcost sensor technologies and wearables with a particular focus on air quality and related environmental measures citiobs will formalise valorise and legitimise the role of citizen observations
de novo formation of the generative plant meristem in 4d

meristem formation is essential for continuous and organised growth in all land plants the meristem is a multicellular generative centre that produces the plant body and is maintained by spatially restricted gene expression domains throughout a plants lifespan however little is known about how these stable patterns are established de novo from a single cell this is because embryonic meristem formation in flowering plants is enclosed within the seed and fruit and therefore live imaging chemical treatments and gene interaction studies are technically difficult the bryophyte marchantia polymorpha has emerged as a powerful model to investigate meristem formation in real time the singlecelled marchantia haploid spore is exposed and undergoes defined patterns of cell division to ultimately produce a highly organised meristem in the proposed project spatial and temporal gene expression changes will be observed live during meristem formation and the molecular interactions driving these changes will be identified as well as revealing how gene expression patterns and feedback loops can form de novo this work will reveal key innovations during meristem evolution and identify the fundamental requirements for meristem formation in land plants
operando analyses and modelling of interface dynamics and charge transport in lithiumion batteries

battery innovation has played a major role in the development of new energy production transport technologies becoming true enablers of a clean affordable and secure energy economy however innovation is currently being hindered by the lack of understanding of the processes happening at atomic levels in the batteries interfaces and interphases thus the opincharge consortium aims to develop a set of effective operando nanoanalytical techniques and methodologies to understand the interfacial processes in batteries in unprecedented level of detail for this 10 organizations from 7 different countries will work together combining their expertise and infrastructure to find new ways of addressing this challenge this will be fostered through 3 main pillars of technique innovation chemicalbased isotopebased and physicsbased consequently main techniques to be addressed operando will be xray scattering enhanced raman stemeels edx fibsims neutron imaging oems and nmr parallelly the consortium will integrate aimachine learning support in order to improve data acquisition and analysis making the data crunching processes more efficient and meaningful likewise data treatment and sharing are cornerstones of the project as open science practices and scientific collaboration with the community are recognized by the consortium as key aspects of the bigmap objectives of the batteries partnership and 2030 programmes with a 36 month duration the project is divided in 7 work packages distributed among the partners according to their expertise with list as leader of the consortium dissemination exploitation and communication activities will allow to maximize the impact of the results and the outreach of these by actively promoting the diffusion of the information derived from the activities of the project
foundations for antitrust and policy on digital platforms

internet markets tend to concentrate in the hands of a very few large platforms these platforms have been accused of abusing their monopoly power visavis their users consumers sellers advertisers and maintaining the latter through hostile behavior towards potential competitors they are said to harm users by selfpreferencing data harvesting creating monopoly positions and extracting resulting rents with high fees all the while avoiding competition by acquiring copying and otherwise disadvantaging potential competitors this proposal addresses these concerns in four parts part 1 focuses on the dual role of online marketplaces whereby the platform both runs the marketplace and acts as a seller on it i aim to understand how such hybrid marketplaces conduct themselves toward consumers and third party sellers the model will be used to evaluate recent policy proposals and suggest ways to avoid significant unintended consequences part 2 studies how platforms steer consumers to sellers as most platforms let sellers set prices and collect fees on revenues a platforms own algorithm and her choice to augmentreplace it with a position auction may be consequently driven by revenue maximization i plan to show that steering systems may drastically alter pricing leading to mediated competition part 3 explores the nature of recommendation algorithms particularly the interplay between consumer search and algorithm effectiveness i demonstrate that algorithms may be selffulfilling and selfdefeating which determines their effectiveness and significantly alters the resulting allocations and their efficiency part 4 explains the circumstances in which an incumbent platform may acquire an upstart platform these depend on the overlap of existing user bases increasing returns to data and monopoly power over advertisers acquisitions may be used in situations of both no and substantial overlap in user bases with mixed welfare consequences
education and naturebased solutions enable society to bend the curve for biodiversity

in response to the increasing need for cooperation in learning and skillscapacity development for environmental sustainability including biodiversity and naturebased solutions nbs learning and teaching enabls will set the basis of networking and collaboration with a view to promoting transdisciplinary dialogue and further embedding and unfolding nbs concepts and approaches within universities and vocational schools the professional sphere and society at large enabls envisions the creation of 7 living labs de nl fi at lt gr cz to epitomise an integrative approach that includes all voices and leaves no one behind collecting a variety of input and welcoming a plurality of values and knowledge the goal is to mainstream biodiversity and nbs in higher education and tvet technical and vocational education training by developing and upscaling new forms of teaching learning and capacitybuilding that are more relational systemsoriented and applied this should be achieved through multiactor collaboration and a whole institution approach wia universities become their own living labs that spans the curricula pedagogy and didactics professional development institutional practices schooluniversitycommunity relationships and institutional ethos vision and leadership doing so implies working together across silos sectors and epistemologies as well as a paradigm shift in education and the development of sustainability competencies the ultimate objective is for enabls to contribute more generally to i the advancement of a nature positive society through the necessary transformative change of communities business models and lifestyles and specifically ii put biodiversity and climate on the path to recovery responding to the objectives of the eu biodiversity strategy for 2030 and the eu climate adaptation strategy
hydrogen electrical engine novel architecture

hylena will investigate develop and optimize an innovative highly efficient hydrogen powered electrical aircraft propulsion concept this is based on the integration and combination of solid oxide fuel cells sofc with turbomachinery in order to use both the electric and thermal energy for maximisation of propulsive efficiency this gamechanging engine will exploit the synergistic use ofa an electrical motor the main driver for propulsionb hydrogen fueled sofc stacks geometrically optimized for nacelle integrationc a gas turbine to thermodynamically integrate the sofc this concept will achieve significant climate impact reduction by being completely carbon neutral with radical increase of overall efficiency for short and medium range aircrafts the hylena methodology covers on sofc cell level experimental investigations on new highpower density cell technologies sofc stack level studies and tests to determine the most lightweight and manufacturable way of stack integration thermodynamic level engine cycle simulations of novel hylena concept architectures engine design level exploration through resilient calculation and simulation of the best engine design sizing and overall components integration overall engine efficiency level demonstration that hylena concept can reach an efficiency increase of more than 50 compared to stateoftheart turbofan engines demonstration level a decision dossier for a potential ground test demonstrator to prove that the concept works in practice during a second phase of the projectthe hylena consortium consists of one aircraft manufacturer airbus 3 universities and 2 research institutes covering the expertise in aircraft design propulsion system design sofc technology hydrogen combustion and climate impact assessment this project is fully complementary to cleanaviation to investigate a low level trl concept and bring it to trl3 in 42 months prior to a demonstrator in phase 2
a disruptively novel approach to clean and safe water supply to offgrid communities safewatersdcw

solardew has developed a disruptive point of use water purification technology it may look like a solar panel but instead of electricity produces high quality drinking water through a process of membrane distillation the process follows the natural cycle of evaporation and condensation of water removing salts heavy metals bacteria and viruses in a single step this unique nonporous membrane is low cost 20x cheaper and highly resistant to contamination compared to existing membranes the membrane is integrated into a water purification bag using manufacturing technologies from the packaging industry for high quality and low cost it is integrated into a single unit and powered exclusively by solar thermal energy making it robust and easy to use compared to bottled water customers can save up to 2040 centslitre the technology is in line with un sdg 6 green deal goals was financed by the innowide program and won the seal of excellence in the eic accelerator dec 20
the role of military equipment in peacekeeping operations advancing knowledge on mission performance

when are peacekeeping operations pos successful a leading answer from quantitative peacekeeping research is that mission size and personnel composition matter the larger the deployment the higher the number of uniformed troops and the more culturally different the peacekeepers the better peacekeeping performance practitioners on the other hand oftentimes highlight that adequate military equipment is crucial in this regard due to the lack of structured crosssectional timevarying data on how pos are equipped peacekeeping scholars have thus far not been able to directly evaluate these appeals in a systematic manner consequently it is unclear whether pos are indeed underequipped whether and to which extent this varies across cases and what role equipment deficiencies play for peacekeeping performance romeo addresses this significant research gap in three ways first it systematically synthesizes and structures information on how pos are equipped ro1 recording which country contributes material to which po supporting which operational function with how many items of equipment using which specific system for 87 un and nonun pos in subsaharan africa between 1991 and 2023 wp1 second romeo establishes basic empirical knowledge on military peacekeeping equipment ro2 by descriptively exploring the new equipment data from wp1 and other sources along four dimensions availability suitability stateoftheart and technical interoperability to compare equipment deficiency over time a across un and nonun pos b and within different actors over time c third it advances our understanding on the conditions under which peacekeeping works ro3 as it uses the multidimensional information from wp2 to statistically model the relation between military equipment deficiencies and the ability of pos to limit conflictrelated violence especially against civilians wp3
incypro a key technology to enable the broad application of proteins in diagnostics and therapeutics

proteins are not only one of lifes main building blocks but also key tools for many industrial applications ranging from drug discovery and diagnostics to chemical production processes the main limitation of proteins is their low stability at nonphysiological conditions as they are commonly required in industrial medical and biotechnological processes consequently proteins often loose structural integrity and activity under relevant conditions there are thousands of proteins with large potential for instance in the context of protein targets related to diseases with high unmet need pointofcare diagnostics and protein therapeutics however many cannot be utilized due to a lack of generally applicable technologies that allow straightforward and meaningful protein stabilization to address the challenges associated with protein stabilization a versatile technology overcoming costly timeconsuming and uncertain trialanderror approaches is required the incypronext project aims to provide a universal solution to the stabilization of proteins for biotechnological and biomedical applications in the frame of the erc poc project incypro we have developed a radically new technology for stabilizing proteins that has been validated in lab our innovation combines structural and molecular biology as well as chemistry to provide a highly effective and efficient technology for the stabilization of a broad range of proteins that are currently impossible to stabilize delivering minimally modified proteins with a highly stabilized structure and retained functionality this is an ideal value proposition to play a key role in a growing 170 b market which can allow us to both offer b2b services to customers in the pharma biotech research and industrial processes segments as well as to start our own internal drug discovery and development pipeline in this eic transition project we will validate the incypro technology in a real operating environment trl5
fostering linguistic capital a roadmap for reversing the diversity crisis and activating societal benefits in europe

the fosterlang project aims to have a transformative effect on how minoritised languages are protected used and promoted in europe in the context of the competitive societal dynamic between dominant and nondominant languages this will be achieved by developing evidencebased diagnostics of the minoritylanguage condition and by suggesting strategic and technologically informed initiatives to protect and enhance their socioeconomic position the project consortium brings the crosscultural multidisciplinary expertise of 14 participating organisations in an ambitious partnership of intellectual enquiry on key societal aspects of protecting the eu linguistic diversity its members combine strengths and expertise in sociolinguistics social anthropology education and pedagogy language planning digital innovation computer science public policy and language revitalisation the partners will work in tandem to develop a new societal and institutional dispensation by which minoritised language communities will catalyse their contested linguistic capital to counteract the sociopolitical and economic forces which continue to undermine a sustainable future for europes linguistic minorities and migrants the work packages are centred on fostering linguistic capital not only from the perspective of protecting europes multicultural diversity but also to indicate how linguistic capital can enhance other components of human capital such as economic demographic and healthrelated wellbeing the project aligns with strategic priorities of eu and the horizon europe programme in fostering societal coherence of different linguistic communities living in their shared spaces the major outcome will be a linguistic capital road map which will set out a substantive set of recommendations for the short medium and longterm on effective and meaningful strategies for fostering europes linguistic capital and for safeguarding grassroots multilingualism
the survival of damaged medieval polychromed heritage in the nordics

polychrome will study the shifting fortunes of richly painted and gilded polychromed christian images that have survived in the nordic countries since the reformation how have wooden sculptures panel paintings shrines and winged altarpieces transformed from potent objects of devotion to cultural heritage to what extent is this category of cultural heritage at risk values attached to catholic devotional objects have fluctuated dramatically since gustav i of sweden and christian iii of denmarknorway declared a break with the church in rome 1527 and 1537 respectively however documentary sources shed little light on changes in status volatility and repairspolychrome will take an ambitious leap that scholars concerned with polychromy in denmark norway and sweden have been reluctant to make to determine the extent to which losses of noses eyes and limbs are tied to iconoclastic acts to date historians and most conservators have attributed damage to accidents or unspecific vandalism but not to targeted violence this is due in part to a lack of archival evidence but also because secondary paints often mask critical information on surfaces and in internal structures polychrome will harness technologies from the natural sciences to create from the ground up the first analytical overview of c 150 polychromed objects that are or potentially were partially mutilated the material data will offer essential foundations for determining whether damages and losses can be linked to violence accidents or inherent weakness the data will guide the mapping of restorations and repairs and will establish foundations for multidisciplinary studies and crosscultural debates about heritage values and the future care of religious heritage in the nordics the outcomes will complicate conversations about the preserving effects of lutheranism on medieval devotional objects and will influence training priorities for years to come
post taliban afghanistan the future of militancy in pakistan

the us withdrawal from afghanistan in 2021 and the subsequent takeover of taliban has reinvigorated militancy in the border region of pakistan the border region formerly known as a federally administered tribal areas fata became home to domestic and international terrorist organizations such as tehrikitaliban pakistan ttp alqaeda afghan taliban and islamic movement of uzbekistan imu after 911 fata was used as a training ground for orchestrating terrorist attacks in pakistan afghanistan united states us and european countries domestically the terrorists unleashed an era of terror killing thousands of innocent people they assassinated pakistans former prime minister benazir bhutto and shot malala yousafzai they attacked schools health facilities and banned polio vaccination the 77 london attacks and new york attacks 2010 were planned by the ttp in the tribal areas of pakistan pakistans security forces conducted military operations against the militants and militancy began to decline after 2016 however the recapturing of afghanistan by the taliban in august 2021 has provided new energy to the militants fighting in the tribal areas they are grouping they are seeking alliance with international terrorist groups and can them refuge in the tribal areas this project will investigate the reemergence of ttp addressing the following key questions what are the key factors responsible for the reemergence of ttp in pakistan how the reemergence of pakistan taliban can pose challenges for women in the area how the alliance of ttp with international terrorist groups such as alqaeda and isk can create challenges for global security what are the policy options for pakistan and the world to counter the reemergence of ttp and its alliance with other terrorist groups