Dragon09/odtu_chatbot huggingface dataset:
multiomics characterization of immune triggers in moyamoya disease

this project aims to characterize a recently discovered link between a rare genetic disorder of the brain called moyamoya disease mmd and the cellular immune response against microbial infections mmd is characterized by a progressive occlusion of arteries at the base of the brain leading to stroke mutations in ring finger protein 213 rnf213 represent the most common genetic cause of mmd however it is suggested that environmental stimuli are needed to trigger disease onset in genetic carriers intriguingly we recently discovered rnf213 as a novel antibacterial protein that can target intracellular listeria gram providing strong protection to listeria both in vitro and in vivo similarly rnf213 can bind intracellular salmonella gram mediating its ubiquitindependent degradation moreover we also identified rnf213 as a cellular sensor for proteins modified by isg15 isgylated proteins a ubiquitinlike modification of the immune system induced by interferon these observations not only uncover rnf213 as a novel key antimicrobial protein they also suggest an important role for the immune system in triggering mmd multimoya starts from the hypothesis that dysregulated immune responses to infections might trigger mmd disease onset in patients carrying mutations in rnf213 to investigate this hypothesis we will determine whether mmd patientderived immune cells respond differently to interferon lps or bacterial infection by mapping altered pathways using a multiomics approach combining genomics transcriptomics proteomics and tracer metabolomics data results will be validated by biochemical and imaging analysis in relevant patientderivedlike cellular models as well as in mouse models of mmd that we will establish together these experiments will provide unprecedented insight into mmdrelated immune responses and fundamental processes that link cellular immunity with vascular disease
bridging the gaps in evidence regulation and impact of anticorruption policies

bridgegap is a multidisciplinary research project reuniting former members of the anticorrp consortium transparency international ercassar csd university of pisa university of perugia who have continued to invest in the development of data commons allowing corruption understanding and monitoring on the basis of objective data eg integrity watch index for public integrity tindex russian economic footprint with new academic partners who published novel methods to measure moneylaundering utrecht university anthropologists and criminologists who pioneered corruption studies in liberal democracies iffs and new it groups like the ukrainian organisation youcontrol the first to interconnect data to enable searches of the assets of sanctioned individuals through its algorithm follow the money bridgegap fills the knowledge gaps regarding both the extent to and the mechanisms by which corruption infiltrates open societies even across borders and it produces measurements of corruption across countries and time by its innovative models as well as social network maps it also assesses and offers solutions to the digital transparency gaps ranging from the tools of transparency the use and abuse of technology in corruption and anticorruption to the state of it finally it assesses public accountability and anticorruption regulation across eums and candidate states to identify regulatory and impact gaps thus addressing the academiapolicy gap in corruption studies the research will result in academic publications as well as in interactive analytical and research commons like comparative law repositories eu compass european transparency index follow the money search engines across newly interconnected databases all its pooled data will be displayed transparently on the website as a data hub and will offer end users the same investigation and analytical tools as the project researchers inviting crowdsourcing and offering online tutorials
modulating tregs in liver disease for therapeutic benefit

regulatory t cells tregs are important for maintaining tolerance to self and are known to contribute to appropriate priming in the case of foreign challenges however their role in liver homeostasis and disease remains to be determined liver disease represents a significant global health issue with hepatitis b virus hbv metabolic dysfunctionassociated steatotic liver disease masld and hepatocellular carcinoma hcc resulting in considerable morbidity and mortality worldwide and limited treatments are available to address these conditions this project aims to identify novel mechanisms of targeting tregs in liver disease to suggest methods to manipulate these cells for therapeutic benefit cuttingedge mouse models of hbv masld and hcc will be used to determine the phenotypes kinetics and localisation of tregs in the liver under homeostasis and during disease high parameter flow cytometry spatial transcriptomics and stateoftheart intravital imaging will allow us to investigate highresolution spatiotemporal dynamics of liver tregs to identify novel molecules interactions and functions of these cells tissue samples from human patient hbv and hcc cohorts are available to the host lab and can be used to screen and refine the molecules of interest identified in mouse liver tregs to focus further investigation on clinically relevant molecules the role of tregs in t cell priming in hbv and effects on masld progression and hcc development will be determined using mouse models to specifically deplete tregs or delete molecules of interest in tregs at defined disease stages overall this project will significantly advance our understanding of tregs in the liver and has the potential to reveal promising clinical targets the training in experimental techniques research communication and transfer of knowledge my career will be developed towards my goal of becoming an independent researcher
hidden in the forest environmental history and ethnobiology of charcoal burning in central and eastern europe since the19th century

uncovering the details and impacts of different forest uses and their related socioecological systems is essential for understanding forest ecosystems one of these uses is charcoal burning it was a common type of forest use in europe from prehistory until the 20th century nowadays it is recognized mainly as part of cultural heritage although it still functions as a raw material source in the production of additional energy most studies about charcoal production focus on the history and vegetation impact before the 19th century in western europe and prioritize the male perspective of this forest use the aim of this project is to examine the environmental history and vegetation of active and abandoned charcoal kiln sites emphasising the role of women and children in this forest use and the traditional ecological knowledge of charcoal burners since the 19th century in central and eastern europe the project will apply ecological ethnobiological and historical data collection methods in three work packages wp1 literature review wp2 field work wp3 archival research the project will provide novel data about nontimber forest uses and highlight the role of women and children and their active role in charcoal burning research into the interaction of sofar neglected groups with nature will support the preservation of the biocultural heritage of european forested landscapes and provide new insights for energy production and landscape management to achieve these goals i will use the facilities of the host institute hi the institute of botany of the czech academy of sciences and the secondment place the university of turin the expertise of my supervisor at the host institute dr pter szab and mentor of the sp dr giacomo bonan in interdisciplinary research of forest history will provide me with an excellent background that will broaden my horizons and contribute to my further development in academia
merging sustainable and digital chemical technologies for the development of greenerbydesign pharmaceuticals

safe and greenbydesign are premarket design approaches whereby the objectives of minimizing the use of hazardous chemicals reducing greenhouse gas emissions and fostering the reuse and recycling of materials in a circular economy are built into product design suspharma fits the european need for sustainable development in modern industry and will develop during the action greener routes to prepare molecules such as therapeutics and diagnosticsthe breakthrough innovation will involve use of renewable biobased carbon for the building block of scaffolds and motifs for drug synthesis cleaner synthetic methodologies for cx bond formation that is ch functionalization to obtain cc cf and ci bond formation development of new benchtop continuous purification methods to remove impurity and recycle synthetic solvents integration of digitalization methods lca and tea assessment for sensibly reducing the impact of pharmaceutical productionthe project will thus benefit from an interdisciplinary domain involving recent advances in biomass conversion for drug synthesis new developments in heterogeneous catalysis cuttingedge flow chemistry technologies including synthesis and purification automation and machine learningto address the challenge of green and digital transition and proper supply of health technologies and products suspharma will focus on research and innovation activities that aim at integrating five breakthrough concepts cattopharma wastetopharma flowtopharma purtopharma and digital to pharma this will deliver results that are directed to pharmaceutical industries researchers and innovators prompting them to develop and produce greener pharmaceuticals that are either greener by design intrinsically less harmful for the environment or use greener and economically more sustainable manufacturing processes and technologies
carboncaps efficient and verifiable carbon removal with ecosystem cobenefits

we have developed a patent protected innovative flash carbonisation pyrolysis technology for the production of biochar a stable form of carbon that can be used as a carbon sink this high temperature high pressure method can be used to produce reproducible high surface area fixed carbon content and electroconductive biochar our biochar is verified to sequester 32t of co2 per tonne of biochar making it one of the most efficient ways to sequester carbon today in addition for every ton of biochar produced 95mwh of carbonneutral heat is generated in the form of syngas that can be used for municipalindustrial energy needs displacing fossil based heatkey technical benefits of our technology include wide feedstock range inc high moisture content 5 35 high stable solid carbon yield 5060 high surface area biochar 200 400 m2g low toxins volatiles 10 low ash 5 modularscalable systems with planned use of byproduct syngas heat safely
twinning on functional layered materials for advanced applications

radical technological transformation in the last one hundred years have been based on the understanding electronic properties of materials that has enabled their application in electronics energy harvesting among others there is no doubt that the solution to the new challenges of our time will also come from the understanding of materials and their applications in this context layered materials are very promising on account of their broad range of electronic properties including insulators semiconductors conductors superconductors ferromagnets and antiferromagnets that can lead to a variety of applications funlayers will focus on two types of applications energy storage and spintronicsthe exploration of layered materials is such a vast enterprise that requires the engagement of an army of different institutions there is a huge effort worldwide and if europe wants to remain competitive and be a major player in this incoming revolution it is essential to strengthen the capabilities of institutions everywhere most notably in widening countries funlayers will bring together three partners to march together in this direction two consolidated research institutions with outstanding scientific reputation mpg and albacells and inl in portugal taking advantage of incipient collaborations in layered materials this twinning exercise will put inl to speed in this blooming research field and will benefit all partners thanks to their complementary strengthsfunlayers will identify weak points in inl research capacity and provide training knowledge sharing exchange of good practices and access to facilities to address these points it will engage the three partners in collaborative research aiming at high impact results and lay the foundations to sustain this collaboration and the positive impact of the project over time and bring concrete solutions to our greatest challenges namely climate change and low energy consumption
upskilling researchers for sustainable entrepreneurship based on innovation process management

public academic institutions are recognized as an actor capable of energizing entrepreneurship ecosystems to transform the business sector and strengthen the general welfare through sustainable entrepreneurship since sustainable entrepreneurship and innovation has been getting more and more attention the use ipm aims at encouraging entrepreneurship focused on sustainability and creating innovative solutions that respect a threenorms framework doing good avoiding harm and protecting both the society and the planetthe improvement of the relationship between the academic and nonacademic sector in widening countries will be achieved via implementing practices for gaining benefits with sustainability justification this is considered highly valuable for improving the competitive posture for both types of institutions academics and business and making entrepreneurial ecosystem of widening countries more inspiring and supportive for new business ideas development the primary goal is to enhance knowledge and skills of talents from widening countries in the field of research and innovation ri and consequently to raise the capabilities of the widening academic institutions in order to increase their value regarding the sustainable entrepreneurship ecosystemsmoreover the use ipm will contribute to enhancing the career prospects not only of the talents involved in the project but of other researchers at the widening sending institutions as well as talents will share knowledge gained during the secondments towards the nonwidening eu countries additionally the use ipm will boost the entrepreneurial and innovation process management skills of business representatives by transferring the acquired knowledge and skills via trainings implemented though 4 directly impacted centers for entrepreneurship and innovation onwards ei centers these centers will be established andor consolidated thanks to the acquired knowledge and skills gained during the workshops at eu academic institutionsthe main results of the use ipm include 28 seconded talents to 5 partners from eu countries 5 nonacademic partners 4 established andor consolidated ei centers in 4 different widening countries 200 young people young use ipm trainees educated on the acquired acquis 80 trained business representatives business use ipm trainees in the field of entrepreneurship and innovation 40 innovative solutions created during the internships under the crosssectoral teams and 10 best practices for crosssectoral talent circulation identified last besides contributing to the reversion of brain drain in their countries via increasing youth employability the use ipm will strive to improve a better gender balance in a male dominated entrepreneurship sector
fascinating world of researchers in the age of technology alliance with citizens

the main objective of our proposal is to bring researchers closer to the general public engage them with citizens and encourage the youth especially girls to embark on scientific careers we will use a missionoriented impactfocused approach in order to address global challenges and provide innovative solutions researchers their work and hobbies will be presented in an interactive way that educates the public especially pupils about research and innovation a special focus will be given to cocreation the role of ri in the society and the economy and societal relevance of eu research policy and to improve science communication researchers to schools pre post events will be organised throughout the two years in order to sustain pupils interest raised and support teachers developing new entertaining approaches when educating priority topics such as digital green and sustainable development health etc the involvement of many different actors across various disciplines and sectors will achieve a high impact and make researchers work familiar our main target group is students of age 626 but we aim to address all age groups with attractive programmes and demonstrate that both scholars and innovators can be discovered amongst us and being a researcher is indeed cool and creative our venues cover the whole country as the result of the awareness raising campaign several organizations will join the researchers night the most important science communication event in hungary thus contributing to the multiplication of the visitors we have the experience of 11 years to reach our ambitious but realistic goal of getting 30000 people at our venues on the twoday event but many more will attend at partners venues that join later millions will see hear or read about the night at each venue eurelated info points will be set up to raise awareness of the eu engagement in ri through the participation of eu projects with a special focus on mscas
artificial neural networks for the prediction of contrails and aviation induced cloudiness

contrails and aviationinduced cloudiness effects on climate change show large uncertainties since they are subject to meteorological regional and seasonal variations indeed under some specific circumstances aircraft can generate anthropogenic cirrus with cooling thus the need for research into contrails and aviationinduced cloudiness and its associated uncertainties to be considered in aviation climate mitigation actions becomes unquestionablewe will blend cuttingedge ai techniques deep learning and climate science with application to the aviation domain aiming at closing at least partially de existing gap in terms of understanding aviationinduced climate impact the overall purpose of econtrail project is to develop artificial neural networks leveraging remote sensing detection methods for the prediction of the climate impact derived from contrails and aviationinduced cloudiness contributing thus to a better understanding of the nonco2 impact of aviation on global warming and reducing their associated uncertainties as essential steps towards green aviation specifically the objectives of econtrail areo1 to develop remote sensing algorithms for the detection of contrails and aviationinduced cloudinesso2 to quantify the radiative forcing of ice clouds based on remote sensing and radiative transfer methodso3 to use of deep learning architectures to generate ai models capable of predicting the radiative forcing of contrails based on dataarchive numerical weather forecasts and historical traffico4 to assess the climate impact and develop a visualization tool in a dashboardupon successful achievement of the objectives described above we ambition to provide aviation stakeholders with an early and accurate thus reducing the associated uncertainty prediction of those volumes of airspace with the conditions for large global warming impact due to contrails and aviationinduced cloudiness
crosslinguistic influence during realtime processing in child heritage speakers

the project clear crosslinguistic influence during realtime processing in child heritage speakers investigates the role of crosslinguistic influence in realtime sentence processing to fill the gap in the ongoing debate about whether languages interact in the mind of a bilingual child some argue that the general bilingualism effect rather than the crosslinguistic influence affects language comprehension what is lacking in this field of research however is a systematic understanding of what happens in realtime processing we focus on crosslinguistic influence in pronoun interpretation by testing severely understudied bilingual population ie child heritage speakers of croatian we approach the phenomenon in a new and unique way by examining the crosslinguistic influence in relation to the implicit causality bias which is assumed to facilitate language comprehension clear takes a novel methodological approach by comparing children in three european countries croatia italy and norway the two language combinations croatianitalian nullsubject languages and croatiannorwegian nonnullsubject language allow us to gain insight into the role of structural overlap between languages to better understand the phenomenon both childrens eye movements and offline responses will be measured clear will make a significant contribution to research on heritage language bilingualism by revealing whether the languages a child acquires influence each other or whether difficulties in language comprehension are due to the general bilingualism effect ie limited processing abilities the project addresses aspects that are of great importance for teachers of secondforeign languages as well as for speech and language pathologists by promoting bilingualism and interculturality across europe by carrying out this project i will gain considerable expertise in the field and become an independent and internationally recognised researcher
dynamic belief updating in mice rats humans and models

the environment is structured in time allowing humans and animals to make predictions about the future and adjust behaviour to this end they perform dynamic belief updating whereby beliefs about event probabilities are iteratively revised in light of new observations however this strategy is challenged by two properties of the world namely stochasticity and volatility these features imply that an unexpected observation might either simply reflect noise in the generative process or indicate that the process itself has covertly changed while remedying to stochasticity requires to integrate over past observations so as to cancel out noise from the estimates the countermeasure for volatility instead dictates to discard past observations so as to compute the most uptodate estimates how do humans and animals strike this difficult balance in this interdisciplinary proposal i offer to tackle this question using a unique combination of human cognitive neuroscience and rodent neurobiology all guided by computational modelling authorities in these fields valentin wyart phd and benjamin b scott phd will provide me with the missing skillset which combined with my preexisting expertise will put me in an unprecedented position to unravel how mammalian brains factor in uncertainty during dynamic belief updating notably i will test the idea that a sensory gain control mechanism gates the impact of novel observations onto past beliefs and that this sensory gain is tuned by noradrenaline release from the locus coeruleus the findings will inform neurocomputational theories of learning as well as contribute to a better understanding of crossspecies similarities and differences which is key for more fruitful translational research programs and better optimized use of animals in research furthermore the acquired skillset will ideally position me as an independent researcher equipped with a cuttingedge approach at the frontiers of fields and species