Dragon09/odtu_chatbot huggingface dataset:
meiotic adaptation to allopolyploidy

hybridization between related species resulting in allopolyploidy is ubiquitous in the evolutionary history of plants such nascent allopolyploids face the challenge of ensuring accurate chromosome segregation during meiosis in the presence of related but nonidentical chromosome sets called homoeologues inherited from the allopolyploids progenitors essential for fertility this relies upon the formation of physical connections crossovers between homologous chromosomes while crossovers between homoeologues that could lead to aneuploidy must be prevented meiotic stability in the allopolyploid context thus requires a tight control of recombination partner choice the existence of highly fertile natural allopolyploids shows that solutions exist and have arisen many times during evolution but the mechanisms involved remain poorly understood my goal is to elucidate the evolutionary processes of meiotic stabilization of nascent allopolyploids with a special emphasis on the molecular mechanisms that prevent recombination between homoeologous chromosomes i propose to recreate in the lab the natural hybridization that happened 16 kya between a thaliana and a arenosa leading to arabidopsis suecica in order to characterize the mechanisms underlying the evolution of the young allopolyploids over the first generations as they acquire meiotic stability and full fertility the proposed project has three main objectives 1 map and characterize genomewide recombination between homoeologues 2 identify the factors that control homoeologous pairing and recombination and 3 elucidate how this control is progressively set up in newly formed allopolyploids our studies have the potential to bring new and fundamental insights on the evolutionary processes enabling meiotic stabilization of nascent allopolyploids and to contribute to polyploid crop improvement through knowledge transfer to plant breeding programs
continuous electrolyticcatalytic decoupled water electrolysis for green hydrogen production

h2bro will develop a transformative decoupled water electrolysis process for green hydrogen production it aims for high efficiency in a continuous and isothermal process that supports membraneless electrolysis with highthroughput and minimal energy losses going far beyond other electrolysis processes i propose to achieve these goals by dividing the oxygen evolution reaction into two subreactions electrochemical and chemical ones carried out in different cells towards this end i propose to use a soluble redox couple that will be oxidized electrochemically while hydrogen evolves at the cathode in one cell and reduced spontaneously in the presence of a catalyst in a chemical reaction that evolves oxygen in another cell i have identified the bromidebromate couple as a promising candidate due to its high solubility and suitable redox potential fundamental materials challenges will be addressed in developing the electrolytic process with an aim to achieve high efficiency and selectivity to produce bromate without volatile side products such as o2 or other loss reactions and a suitable catalyst for spontaneous bromate reduction and oxygen evolution addressing these challenges requires a multidisciplinary research in materials science electrochemistry catalysis and process engineering where questions of materials selection and catalyst activity and selectivity intertwine with process parameters such as electrolyte composition temperature and flow with an ultimate goal of combining the electrolytic and catalytic subprocesses into a seamless process in a flow system that generates hydrogen and oxygen in different cells at high efficiency and rate progress towards these aims will lead the way to a competitive solution for green hydrogen production to fight global warming and advance the science of catalysts and electrodes for advanced water electrolysis and related technologies
a greekturkish solar energy excellence hub to advance the european green deal

solarhubs overall objective is to strengthen connections between and scaleup 5 greek and turkish solar energy innovation ecosystems as a single hybrid crossborder and interconnected solar energy excellence hub with an emphasis on agriculture applications solarhubs 4 specific objectives sos are explicitly framed by the calls 5 core components and target the calls expected outcomes and the destinations expected impacts these sos are to1 codevelop a hub strategy and a joint strategic research innovation agenda2 execute a diverse set of complementary interventions engaging all players of the quadruple helix to support ri and accelerate commercialization 3 implement joint ri activities to codevelop 4 predesigns of diverse solar energy solutions 4 maximize the projects impacts through dissemination exploitation and communication activities carefully tuned to actively engage all players of the quadruple helixto achieve these objectives a diverse and complementary set of measures are proposed that include1 creation of relevant r i strategies policies2 networking between solarhub stakeholders 3 multilevel engagement training4 combination of ri infrastructures for synergies5 creation of targeted joint programmes and linkages between the 2 countries based on sound technological solutions6 communicating the above to all major stakeholders in the targeted regions 7 exploiting the positive results from all the above to setup a sustainable collaborative initiative after the end of the projectsolarhubs consortium contains 21 partners 7 academic 9 business 3 public authorities and 2 societal actors that are wellbalanced between academia and business and fully completes the quadruple helix solarhub is a 4 year project with 5 carefully designed work packages that efficiently exploit the consortiums diverse knowledge and expertise to develop green solutions to todays societal challenges
the culture of algorithmic models advancing the historical epistemology of artificial intelligence

the project proposes an alternative epistemology of artificial intelligence ai it argues that what is at stake in ai is not its similarity to human rationality anthropomorphism but its epistemic difference rather than speculating in the abstract on whether a machine can think the project addresses a historical question what is the logical and technical form of the current paradigm of ai machine learning and what is its origin the project traces the origins of machine learning back to the invention of algorithmic modelling more precisely algorithmic statistical modelling that took shape in the artificial neural networks research of the mid 1950s and records that a coherent history and epistemology of this groundbreaking artefact is still missing the project pursues three objectives to turn its findings into a constructive paradigm 1 a new history of ai that stresses the key role of algorithmic models in the evolution of statistics computer science artificial neural networks and machine learning 2 a new epistemology of ai that engages with the psychology of learning and the historical epistemology of science and technology 3 a study of the impact of the large multipurpose models eg bert gpt3 codex and other recent foundation models on work automation data governance and digital culture through consolidating a model theory of ai the research will benefit the reception of ai in general and fields such as digital humanities scientific computing robotics and ai ethics among others ultimately it will help situate ai in the global horizon of the current technosphere and in the long history of knowledge systems
archimedes drive driving innovation in the robotics industry

imsystems has created the archimedes drive ad a proprietary patented and revolutionary speed reducer based on smooth rolling contact by cylinders that solves the problems of existing speed reducers all based on gear teeth lack of performance for universal applicability all axes all robots expensive manufacturing lack of responsiveness and dependency on japanese suppliersour primary targeted market is the industrial robotics market due to their high impact on industrial productivity robotics companies are in dire need of ultraprecise robust lightweight but still affordable speed reducers we will strategically focus first on european robotics makers eg abb comauwith abb as our likely launching customer and linamar as our manufacturer both investors in imsystems we have already established the right structure to set the company up for growth with the ad imsystems aims to become the leader of speed reducer technologies for the global robotics market by 2035
multiscale research on nanotwinned thermal barrier coatings with high strength and toughness

thermal barrier coatings tbcs have been widely used to protect the substrate of hot components against the hot and corrosive environment which have extensive applications in power sectors aerospace engineering and chemical industrials they are however facing the paradox of conflicting competition between the strength and toughness especially under high temperature aiming to develop high temperature tbcs with simultaneously improved strength and toughness this project proposes an innovative strategy of engineering nanotwinned ceramics and examines their mechanical properties under high temperature with improved mechanistic understanding which include i developing novel nanotwinned tyao4 ceramic materials via hierarchical structures ii examining the mechanical properties of formed tbc materials via a unique high temperature nanoindentation system up to 2000 k 3 establishing a multiscale simulation framework to predict the macroscopic mechanical properties and iv developing a twin boundary affected hardening and crack growth model to reveal the influence of nanoscale structures four work programs are proposed ranging from experiments simulations to theories to realize such an ambitious plan intervened with a careful balanced training program dissemination and management skill development properly implemented the project shall reveal for the first time the effect of hierarchical nanoscale structures on the improved mechanical properties of tyao4 ceramics up to 2000 k which are much needed for the development of next generations of tbcs the project exhibits strong interdisciplinary coupling among materials science and engineering solid mechanics and multiscale computation engineering not only bearing with significant scientific potentials the mutual benefits from this program will booster the career of the researcher significantly and promote long term knowledge exchange and collaboration between europe and china
minimallyinvasive softrobotassisted deepbrain localized therapeutics delivery for neurological disorders

robotics and imaging can revolutionize healthcare by overcoming limitations of existing practice and enabling the clinical translation of emerging treatments along this direction softreach focuses on improving the treatment of neurological disorders nds a major unmet healthcare challenge despite the devastating impact of nds to millions existing treatments have poor efficacy softreach aims to radically improve treatments by providing localized delivery of therapeutics in deepbrain regions involved in nd pathophysiology the proposed platform can enhance the efficacy of pharmaceutical treatments by bypassing limitations of systemic delivery and provide means to implement promising cell therapiesour paradigmshifting ambition will be realised through two major innovations 1 a submillimeter softgrowing steerable robotic platform the first of its kind which will utilize realtime mri feedback to navigate through the spine subarachnoid space and the ventricular system vs where it will attach lsized payloads carriers of therapeutics at specific locations 2 novel lsized tissue construct payloads tcps built around precisely microfabricated deployable porous scaffolds so that they can attach stably on vs walls and deliver therapeutic factors to adjacent brain regionsthe platform will be demonstrated via two parallel efforts 1 the ability of the softgrowing robot to extend via the vs and safely deliver tcps under realtime mri feedback will be demonstrated in highfidelity phantoms of the human vs 2 tcpmediated localised delivery of treatments compounds cells via the vs will be demonstrated stereotactically in miceby providing minimallyinvasive access to deepbrain regions of major clinical importance that lie beyond the reach of existing procedures softreach can revolutionize the clinical practice of nd treatments and provide disrupting tools that can impact multiple fields such as gene therapy neurosurgery and oncology
living populism polarization and quotidian experience

this project aims to offer a novel understanding of populism and its supporters through ethnographic research with leftwing populists in spain i will break with dominant academic approaches to populism based largely in analysis of the discourse of partyelites while spain was once regarded as having resisted the rise of populist groups emerging in other western european countries since the 2008 financial crisis both left and rightwing populist movements now command considerable supportin order to understand this boom in populist power in this project i will explore the process and experience of populist subjectivation instead of treating the people as a semiotic construct i will explore its purchase and functioning as a lived identity as i investigate the experience of being a populist subject this will entail working closely with populist supporters in order to investigate the gendered subjectivities and domestic dynamics that exist in a coconstitutive relationship with illiberal political commitments among other results regarding populisms domestic and gendered elements this will add nuance to commonsense depictions of populism as inherently linked to an aggressive white masculinitymy focus on the everyday lived elements of populist subjectivity will also involve a spatial analysis of populist politics drawing upon anthropological theories of place i will analyse the spaces in which populist politics are made and are manifested this will result in new information regarding how public spaces figure in populist mobilization and populist subjectivation this project promises insights regarding the processes by which populist commitments are adopted by supporters as well as critical information about populists subjectivities these findings will be valuable in the nascent subfield of the anthropology or populism and will be of interest to the public and policy makers as they attempt to understand the global growth of populist politics
reprogramming endothelial cells in immunecold tumors

lung cancer is the leading cause of cancerrelated deaths worldwide currently immunotherapy it is the standard of care for the treatment of some subtypes with only nominal success it works best in inflamed hot tumors and is often ineffective in immune celldesert cold tumors in krasmutated lung adenocarcinoma luad the most frequent type of lung cancer the presence of a mutation in the stk11lkb1 gene is linked to a cold tumor while the cooccurrence of a tp53 mutation corresponds to a hot tumor amongst different cell types in the tumor environment impacting immune cell composition endothelial cells ecs present an important and often overlooked modulator of immune profiles previous research has identified immunoregulatory genes expressed by ecs and proposed immunomodulatory roles of ecs i hypothesize that specific mutations cause the expression of immunosuppressive genes by ecs which might explain the association of gene mutations affecting the immune environment thus modulating ecs to reprogram them into immunostimulatory phenotypes in the immune cold tumors could present a promising strategy to improve it responses to identify the immunosuppressive gene signature in ecs in immune cold vs hot tumors i will utilize transgenic mouse models of luad krasg12d lkb1floxflox kl and krasg12d tp53floxflox kp mice first using scrnaseq i will establish an ec signature linked to the immune cold tumors and subsequently to identify ecspecific candidate immunosuppressive targets after that i will use stateoftheart technologies that enable efficient gene targeting to validate the discovered targets in kl mice i perform multidisciplinary approaches to delineate the molecular mode of action of the target exhibiting a substantial therapeutic effect in mice and overcoming the resistance to current anticancer it finally i will employ a humanized orthotopic lung pdx mouse model to further validate and test therapeutic opportunities
restpoll restoring pollinator habitats across european agricultural landscapes based on multiactor participatory approaches

restpoll is a highly transdisciplinary project aiming to provide society with tools to reverse wild pollinator declines and to position europe as a global leader in pollinator restoration restpoll will together with stakeholders ranging from individual land managers to governments codesign evaluate and refine measures and crosssectoral approaches to restore pollinators and their services the restpoll consortium combines the expertise of natural and social scientists ngos businesses and ministries stakeholders along the food value chain will be engaged through newly developed participatory approaches at diverse social ecological and political scales central to restpoll is the establishment of a europewide network of pollinator restoration casestudy areas and living labs ll which are unique hubs for experimentation demonstration and mutual learningrestpoll aims to position europe as a global leader and set the future agenda for pollinator restoration worldwide the transdisciplinary restpoll consortium will develop test evaluate and refine crosssectoral pollinator restoration approaches to conserve biodiversity and to benefit nature and society to restore wild pollinator diversity and their vital pollination services restpoll will codesign measures with different stakeholders ranging from individual land managers to governments at various spatial scales field farm landscape european scales in agricultural landscapes that are dominated by intensively managed crops or grasslands our holistic approach informed by cuttingedge transdisciplinary research will integrate stakeholders and actors at multiple levels as well as natural and social science disciplines to engage in participatory planning and development of new business models learning outcomes will be disseminated by regional to european multiactor partners and collaborators which will ensure impact beyond the end of the project
capturing the potential of gene editing for a sustainable bioeconomy

new genomic techniques ngts can contribute to an energyefficient lowinput and zeropollution agricultural production and industrial processing despite rapid recent progress this toolbox is still in its infancy and substantial investments are needed to optimise the methods also the innovation potential is fully exploited only if economic social and regulatory drivers coalesce and are accompanied by transparent communication and inclusive stakeholder engagement a problem facing ngt innovation in europe is that regulatory uncertainty restricts investment at all levels research innovation and scaling up and the impacts of ngts both positive and negative are not fully assessed it also remains to be seen if public and stakeholder acceptance of ngt products will enable their application the consequence is that ngts do not yet reach their full potential the research in genebecon has two facets first the technical potential is explored by applying gene editing to develop 1 a virusresistant potato with an industrial tuber starch quality and 2 microalgaebased production of industrially relevant mycosporinlike amino acids second the riskregulatory aspects economic incentives and social perceptions are investigated in the latter comparative analyses are enabled by our approach with two different production systems openfield agricultural crop and containedsystem microalgae the results will enable technical innovations as well as allow stakeholders incl researchers breeders primary producers value chain actors risk assessors and decision makers to take informed decisions on the safe and responsible use of ngtderived products genebecon has a multisectoral consortium and the project links to relevant stakeholders through a stakeholder advisory board this will through communication and inclusive engagement enable an improved understanding and awareness of the risks and benefits of ngtderived products through societal dialogue
biocatalytic cc bond formation by repurposing transaminases

carboncarbon cc bond formation is one of the most challenging synthetic reactions in chemistry current approaches require expensive and toxic transition metals with complex ligands that have limited selectivity developing biocatalytic sustainable methods for the controlled formation of cc bonds with stereospecificity in high yields has the potential to advance organic chemistry and provide access to new molecules although several enzymes are capable of catalyzing cc bonds few biocatalytic approaches have been used in organic synthesis with aldolases being the most used enzyme group plpdependent transaminases ta are the largest and most versatile group and used at industrial scale but have never shown cc bond formation activity in this project i will be developing biocatalytic approaches for cc bond formation by exploring this new functionality of these versatile enzymes thus i will explore the catalytic versatility of tas through protein engineering to allow cc bond formation protein immobilization of engineered tas will support their biocatalytic application in preparative cc bond formation reactions this will expand the biocatalytic toolbox available for synthesis and improve sustainabilitythis project will be carried in the biocatalysis section at tu delft where i will receive training in protein engineering while using my experience in immobilization and cosupervise students this project will give me the opportunity to further develop the research and supervision skills to become a future group leader
sustainable textile electronics

etextile is rapidly developing segment of electronics with an estimated growth from 23 billion usd in 2021 to 66 billion in 2026 they facilitate many socially important applications such as personalized health or elderly care or smart agriculture and production unfortunately today etextiles are highly problematic in terms of environmental impact problems range from toxic materials used for production through energywater requirements to the difficulty endoflife processing systems that combine traditional electronics and textile components the aim of this project is to develop circuit technologies for etextiles that are based on materials that minimize environmental impact are compatible with the lifecycle of normal textiles to facilitate easy reuse in the spirit of circular economy and can be produced and recycled in an energy efficient way the main breakthroughs with respect to the current state of technology will be in three areas 1 a combination of digital inkjet 3d printing and atmospheric plasma to produce sustainable textile electronics building blocks from environmentally friendly materials eg conducting polymers such as pedotpss and carbon based polymer nanocomposites 2 going beyond embedding electronics in textile structures on substrate and layer levels as is state of the art today and using fibrous materials enriched with electronic properties as stipulated above as such to create electronic components such as transistors capacitors etc and combine them into more complex circuits3 comprehensive lifecycleoriented model of the environmental impact of such etextile technologies and their applications overall stelect will create the foundations for a new paradigm for etextiles development that is not just environment friendly and sustainable but also fundamentally changes the way etextiles and wearable systems are designed and built facilitating whole new application domains and associated markets