Dragon09/odtu_chatbot huggingface dataset:
artificial intelligence in fighting illicit drugs production and trafficking

arien proposes the execution of a comprehensive workplan that thoroughly addresses the call topic aligned to the 20212025 eu drugs action plan dap achieved through a holistic innovation action that builds a realtime intelligence picture illegal drug production and trafficking incidence across the eu bolstered by aidriven tools to understand detect analyse and track the entire drugs trafficking chain its financial flows and the role of blackmarkets in the global darknet and their relationships with of social media arien builds on a strong platform of multidisciplinary research following a cocreation approach across the criminological societal and legislative landscapes that will make recommendations for harmonization and drive an agenda for the development of modular solutions embedding modern artificial intelligence ai techniques and best practices for international cooperation in datarich environments in a legally and ethically compliant manner aiming at improving the investigative capability of leas on illegal drugs production and trafficking arien will leverage on innovative ai techniques to monitor online illicit drugs markets and collecting precious information on physical drugdealing hotspots through social media additional layers of analysis supported by explainable ai xai methods will provide actionable knowledge on modus operandi and emerging threats and trends both on drugs and drugrelated organized crime networks through integrations with criminal records data and detection of online activities moreover arien will promote effective strategies on international cooperation among eu and noneu leas customs and border guards authorities and policy makers to enhance investigative activities against criminal groups capitalising on effective ai techniques
real and synthetic scenarios generated for the development training virtual testing and validation of ccam systems

synergies confronts pivotal challenges within the ccam community such as the absence of interoperable scenario databases timeconsuming and expensive development cycles and regulatory ambiguities it achieves this by implementing the safety assurance framework developed in headstart and sunrise synergies furnishes stakeholders with interoperable federated scenario databases incorporating data from safety pool scenario database adscene streetwise vv methods l3pilot hidrive and more this facilitates standardized processes streamlines development cycles and ensures regulatory complianceto accomplish this synergies will culminate in a european platform designed to enhance the development training virtual testing and validation of ccam systems the synergies platform comprises a scenario dataspace aligned with europes approach to data sharing and competitiveness and a marketplace ensuring continual updates and dataspace scalabilityfurthermore synergies encourages the inclusion of new initiatives into the scenario dataspace by offering the requisite tools and guidance from data processing and scenario identification to scenario database governance this presents a unique opportunity to amplify investments in research and development consolidating europes leadership in ccam development all while prioritizing safety and data protection
feedbackcontrol of the microenvironment modular organonchip technology to elucidate the role of neurovascular stress in schizophrenia

a wellcontrolled microenvironment is paramount for reproducible biomolecular studies organsonchips are invitro cell culture systems that employ microfluidic and biomaterial engineering towards that goal they combine the advantages of animal models physiological environment with those of plasticdish culture human cells and thereby hold exceptional promise in unraveling the biological processes that underlie health and disease yet control over the biochemical environment remains poorwith chipzophrenia i propose to develop a new generation of organchip one that features feedbackenabled control of the biochemical environment i aim to realize dynamic and wellcontrolled application of stable therapeutics via feedback sensors and flow control and crucially also of highly volatile oxygennitrogen stressors by relying on electrochemistry to generate them in situ my goal is to moreover implement a highly functional modular architecture so that the system can easily be repurposed and sensorcontrol modules reused all with negligible dead volumes and displacement key challenges in current organchips towards novel functionalitiesi intend to leverage this organchip to elucidate how nitrosative stressors disrupt the complex multicellular interactions of the bloodbrain barrier where existing invitro models fail to provide the requisite cellular and chemical microenvironment yet such disruption is implicated in a wide array of disorders including schizophrenia where our biological understanding remains poor and invivo models are uniquely challenging i will specifically test the hypothesis that nitrosative dysregulation of perivascular cells plays a causative role in neuronal dysfunction associated with the disorder not only will chipzophrenia thus reveal new potential treatment targets but it will also establish the platform as a transformative tool for dynamic and wellcontrolled invitro research into stressrelated disorders and beyond
quantum thermodynamics of precision in electronic devices

quantum technologies exploit the counterintuitive physics of the microscopic world to gain an advantage over purely classical systems in order to achieve commercial usefulness major research efforts are now devoted to scaling up current noisy intermediatescale quantum devices the fundamental challenge to be overcome is noise whose presence is necessitated by basic quantum and thermodynamic principles as well as limitations on the precision with which such devices can be measured and controlled to overcome this challenge we need to understand the fundamental thermodynamic limitations on precision in quantum devices remarkably it has recently been predicted that coherent quantum processes exhibit a new kind of quantum advantage with respect to classical processes the laws of quantum thermodynamics allow higher measurement precision for less energy and entropy costthe ambitious goal of aspects is to demonstrate explore and exploit this novel effect on two of the most promising quantum technology platforms namely superconducting qubits and nanoelectromechanical devices specifically we will design and build quantum circuit devices to experimentally assess the energy cost of timekeeping and qubit readout with support from advanced theory and numerical simulations we will demonstrate quantumthermodynamic precision advantage in our measurements this groundbreaking advance will usher in a new paradigm for quantum metrology in which quantumthermodynamic effects boost both efficiency and precisionour balanced consortium of earlycareer researchers is founded on our strong existing collaborations and our unified and coherent vision for the future of energyefficient quantum technologies bringing together worldleading expertise in precision measurement quantum information and nonequilibrium statistical physics aspects will make a deep and lasting impact on the european quantum technologies landscape
glucose variability patterns for precision nutrition in diabetes

type 2 diabetes t2d has emerged as a global epidemic impacting 1 in 10 people worldwide and causing over 114000 deaths annually in europe despite extensive research understanding the pathogenic mechanisms driving distinct disease subtypes and how diet influences glucose homeostasis has remained elusive this knowledge gap leaves individuals with or at high risk of t2d without effective prevention or control strategies urging a paradigm shift in our approach the glucotypes project brings together leading experts in nutrition metabolic diseases glycobiology gut microbiome epidemiology and machine learning from five european countries to tackle this challenge our strategy capitalises on advancements in wearable technologies molecular biology and bioinformatics we propose to leverage hightemporal continuous glucose monitor data to identify patterns of early glycaemic alterations a concept we refer to as glucotypes and forms the core hypothesis of our research program circulating and adipose tissue glycoproteomics profiling will be used to gain molecular insights into glucotypes machine learning algorithms will be applied to investigate the intersection between diet and glucotypes on clinical outcomes and gain mechanistic insights into how diet and gut microbiome influence glucose homeostasis in specific glucotypes the knowledge derived from these activities will inform a proofofconcept precision nutrition clinical study to test the efficacy of a precisionbased diet on cardiometabolic outcomes and identify markers of beneficial responses to diet in doing so glucotypes will come closer to understanding the divergent mechanisms that influence early glycaemic alterations and how specific diets could ameliorate these alterations our work will establish a foundational yet comprehensive scientific groundwork to inform future precision diabetes nutrition strategies to prevent and improve the lives of all people affected by the disease
bifunctional metal aerogels for unitized regenerative fuel cells

the use of hydrogen as an energy vector is an interesting alternative to face the european energy demand as it can be obtained by splitting water in an electrolyser and then be transformed into electricity in a fuel cell the combination of these two devices to implement a unique and revolutionary technology known as a unitized regenerative fuel cell urfc may transform global energy production which is of paramount importance and a priority in the eu program 20212027 nowadays electrolyzers and fuel cells use noble metals which are costly and scarce and may assume up to 50 of the total cost of a cell thus replacing them is crucial to implement a real hydrogen economy the scientific aim of bifunctional metal aerogels for unitized regenerative fuel cells metgel project is to develop new innovative and lowcost bifunctional electrocatalysts for the sustainable production of energy the societal aim of metgel is to reduce the technologies that use fossil fuels and decrease their adverse environmental effects dr reyraap proposes the microwaveassisted synthesis of bifunctional transition metal aerogels able to catalyse the four electrochemical reactions that take place in a urfc being the first time that these materials are synthesised by microwave heating and used as bifunctional electrocatalysts in a urfc if microwaveassisted metal aerogels combine the unique properties of metals and aerogels properly then they will become extraordinary sustainable electrocatalysts the research will be carried out in the microwaves and carbons applied to technology mcat research group institute of carbon science and technology incar from the spanish national research council csic under the supervision of prof arenillas mcat was the pioneer in implementing microwave technology to synthesise 3dnanostructured materials and has excellent resources and facilities to carry on this research which are the best conditions for the development of metgel project
environmental landscape ethics a theory of cohabitability

this project seeks to establish a new environmental ethics subfield environmental landscape ethics and to develop a new theory around the notion of cohabitability as a focal analytical framework for it because land use for human purposes covers most of earths habitable icefree and fertile land there is a pressing need to develop ethical theory to address land use yet the present environmental ethics is illequipped for addressing land management because it largely builds on the legacy of wilderness orientation that focuses on mitigating human impacts to secure the intactness of nature thus new theories terminology and methods are needed cohab will establish environmental landscape ethics and theory of cohabitability by creating interdisciplinarily constructed ecologyinformed theoretical argumentation methods and conceptual tools cohabitability lands suitability for simultaneous cohabiting by many species is an anchoring concept that connects the key research questions rq1 what are the theoretical and conceptual requirements for environmental landscape ethics rq2 what does cohabitability mean and what is it made of rq3 what are the normative implications of cohabitability rq4 who can and should promote cohabitability and howrqs yield four distinct research perspectives rq1 examines in detail the need for environmental landscape ethics and articulates the methodological and conceptual requirements for a sound approach in this subfield rq2 develops the conceptual framework for the theory of cohabitability by utilising interdisciplinary theory construction and conceptual development in philosophy rq3 examines the normative implications of and creates normative principles for the ethics of cohabitability rq4 examines action for cohabitability from both normative and empirical perspectives answers to rqs will together yield a theory of cohabitability and contribute to the environmental landscape ethics as a novel field
multifunctional biophenols for safe and recyclable materials

the biophenom project will scope and select industrial biomass sidestreams for isolation of biophenols by proven technologies functionalize the isolated biophenols into intumescent flame retardants bioifrs and exploit the bioifrs as multifunctional components for replacement of harmful chemicals commonly used in formulation and functionality improvement of wood thermosets and thermoplastic materials impregnation of wood with bioifrs will enhance fire resistance and durability for outdoor applications while a biobased topcoat will prevent leaching of impregnants and extend service life the bioifrs will be used to produce biocarbon fibres and bioepoxy resins formulated with a novel dynamic hardener that allows resin disintegration thus producing fire resistant and recyclable thermoset biocomposites the bioifrs will also be added to thermoplastic polylactic acid plabiochar composites to enhance fire resistance the most promising applications of the materials developed will be scoped within relevant industrial sectors eg building transportation automotive and their functionality and circularity validated against existing benchmarks circularity will be demonstrated by recycling the treated wood into particleboards recovering the thermoset components for reuse and reformulating the plabased thermoplastics into new biocomposites process and material developments in biophenom will be guided by safe and sustainable by design ssbd principles that will be updated with recommendations on identification of data gaps and priorities for data collection the project data methodologies and results will be made fair ultimately the outcomes of biophenom will enable replacement of harmful substances in material formulations and circularity of endproducts and will increase the portfolio of safe recyclable and sustainable biobased solutions with potential for market uptake benefiting industry consumers and society in europe
an integrated cyber security risk resilience management platform with holistic situational awareness incident response preparedness capabilities

synapse aims to design develop deliver an integrated cyber security risk resilience management platform with holistic situational awareness incident response preparedness capabilities the proposed platform will encompass i incident response through process automation and orchestration mechanisms also covering organisationalbusiness aspects eg business continuity processes ii aienhanced situational awareness encompassing extraction analytics of actionable and pertinent cyber threat intelligence cti along with attack early warning threat hunting systems iii preparedness through cybersecurity privacy business continuity training covering different training delivery means allowing it to tailor the delivery method to the content iv technical economic risk management integrating outputs of iiii above and supporting riskbenefit analyses including whatif scenarios to inform decisionmaking and enable risk transfer schemes with smart contractenabled cybersecurity insurance v continuous feedback between iiv above along with standardsbased sharing alerting reporting intra inter member state based on outputs of iiii above thus enabling the establishment of shared situational awareness coordinated response and joint preparedness
synthact3d pioneering 3d realspace studies of synthetic active matter

autonomous motion and adaptability of microorganisms in fluids are hallmark features of living systems fueling the emergence of active matter within the realm of soft matter physics notably micronsized synthetic selfpropelled particles spps have emerged as a distinct class within this domain due to their unique ability to convert internal energy into directed motion making them ideal models for studying inherently outofequilibrium systems however a significant challenge persists the majority of existing synthetic spps are illsuited for probing the governing principles of emergent collective behaviors observed in living systems such as swarming active turbulence and living clusters particularly in 3d real space the ultimate aim of synthact3d is to pioneer a paradigm shift transitioning synthetic active matter from the familiar territory of 2d experiments towards the uncharted terrain of 3d materials with advanced functionalities this fundamentally driven experimentcentric proposal seeks to unravel the core mechanisms behind emergent phenomena observed in living systems employing entirely synthetic units synthact3d focuses on two complementary goals anchored in a novel experimental framework that combines innovative spp designs rigorous characterization and highspeed confocal imagingi phase behaviorainvestigate the influences of dimensionality 2d vs 3d and particle shape on the emergence of selforganization both structurally and dynamicallybelucidate the role of particle propulsion and the microscopic nonequilibrium dynamics in dictating the macroscopic behavior of spps in 3dii active materialsadesign reconfigurable 3d active materials eg shapeshifting and glasses this research is expected to yield unprecedented insights into internally powered systems in 3d paving the way for a new class of internally driven materials with applications in reconfigurable soft materials
selection versus drift in the rise of deleterious mutations the case of familial mediterranean fever

familial mediterranean fever fmf is the most frequent monogenic autoinflammatory disease worldwide it is caused by mutations in the gene pyrin which are surprisingly frequent up to 20 in individuals of east mediterranean ancestry the evolutionary forces behind such a high local mutation load are unknown but it has been suggested as an example of balancing selection with a selection pressure from past infections hemoglobin disease variants conferring malaria protection are the rare textbook examples of such but are atypical with recent and unusually high selective pressure by taking advantage of the human population history of armenia the excellent preservation conditions of archaeological remains in the region and remarkably high frequency of fmf disease in the armenian population the fevertime project aims to develop the most comprehensive real time account on the role of evolutionary forces in the local mutation burden fevertime will leverage ancient dna time series data from armenia within a sophisticated population genomic analytical framework to yield key results regarding the evolution and spread of the disease the findings will have broad implications for genetic epidemiology reflecting eu policy priorities
characterization of diffuse glioma tumors chemical exposome and potential positive associations with environmental pollution through air particulate matter analysis and wastewater based epidemiology

although chemicals enable a constant improvement of health life quality and facilitate food production industrial applications and advanced agricultural practices their release into the environment may be followed by increased risks for human health humans directly or indirectly are exposed to a diverse mixture of chemicals through multiple pathways which has been acknowledged to play an important role in common chronic diseases including multiple types of cancer but the specific exposuredisease associations have not been explored sufficiently in many cases this is particularly relevant for brain tumors whose causes are still unknown and it is suspected that the environmental components may play an important role since less than 5 of patients have a family history diffuse gliomas are the most common primary malignant brain tumors in adults with poor prognosis and survival therefore identifying environmental contributions to diffuse gliomas development and investigating links with chemical exposures is crucial for improving prognosis and treatment options the objectives of this fellowship are i to explore the chemical exposome exogenous chemicals and associated metabolites of brain tumor tissues by making use of a unique historical cohort of diffuse gliomas patients bellvitge glioma cohort hospital de bellvitge 2005present and ii assess the exposure of barcelona citizens to a mixture of contaminants through the analysis of air particulate matter wastewater and sewage sludge stateoftheart analytical chemistry techniques and data science methods will be integrated to identify potential toxic organic chemicals and their metabolitestransformation products in the environment that may influence the development of diffuse glioma in barcelona the generated results can be used by competent authorities to establish more surgical measures to reduce the emission of very hazardous chemicals and improve both air quality and population health
understanding the origin of structural colors in margaritaria nobilis fruit a molecular dynamics simulation study

structural coloration in plants achieved through the arrangement of cellulose microfibrils into helicoidal architectures within the cell wall is a widespread strategy observed in various plant species including ferns monocots and eudicots despite its prevalence the underlying mechanisms responsible for these hierarchical structures in plant cell walls remain poorly understood to address this knowledge gap this proposal focuses on unraveling the intricate interactions between cellulose and hemicellulstructural coloration in plants achieved through the arrangement of cellulose microfibrils into helicoidal architectures within the cell wall is a widespread strategy observed in various plant species including ferns monocots and eudicots despite its prevalence the underlying mechanisms responsible for these hierarchical structures in plant cell walls remain poorly understood to address this knowledge gap this proposal focuses on unraveling the intricate interactions between cellulose and hemicelluloses the key constituents of plant cell walls using molecular dynamics md simulations the primary objective of this research is to investigate how the chemical composition of hemicelluloses influences the formation of helicoidal structures in cellulose nanofibrils within plant cell walls and subsequently the resulting structural coloration combining md simulation results with experimental data will provide a comprehensive understanding of the impact of hemicelluloses on the helicoidal architecture of cellulose nanofibrils beyond its immediate scope this study offers insights into the biosynthesis of cellulose and hemicelluloses in plant cell walls shedding light on fundamental processes in plant biology by elucidating the molecular dynamics underlying these interactions this research contributes to our broader understanding of structural coloration strategies in the plant kingdom and offers potential applications in bioinspired materials science