Dragon09/odtu_chatbot huggingface dataset:
advanced quantum clock for realworld applications

optical clocks are amazingly stable frequency standards which would remain accurate to within one second over the age of the universe bringing these clocks from the lab to the market offers great opportunities for telecommunications navigation sensing and science but no commercial optical clock exists europes world leading optical clock technology within academia and national metrology institutes combined with its strong photonics industry provide us with a golden opportunity to take a leading position in this strategic technology with aqura we want to seize this opportunity and build up a sovereign efficient industrial capability able to build the worlds most advanced quantum clocks we will deliver the first industrybuilt rugged and transportable optical clock with an accuracy that approaches the best laboratory clocks our work is based on the experience that many of us gained by building an optical clock with industry during the quantum flagship project iqclock 20182022 in aqura industry takes the lead and will deliver a 20x more accurate clock in a 3x smaller volume at trl 7 this will be possible by combining our industry partners experience in rugged photonics products with the knowhow of our worldleading academic and national metrology institute partners we will build strengthen and diversify the european supply chain of optical clock components filling critical gaps in the supply chain and thereby establish a sovereign competitive industry for optical clocks in particular we will develop the rugged laser sources miniaturized optical interface circuits and the atom source needed for an optical clock all of which will also become products on their own partner menlo systems will integrate these components with their ultrastable laser system into the aqura optical clock we will accelerate market uptake by demonstrating our clocks usefulness to applications in telecom geodesy and metrology and by engaging with end users
accelerated seaweed production for innovative and robust seaweed aquaculture in europe

the aspire project will develop fast growing seaweed strains to strengthen europes potential to thrive in an emerging seaweed aquaculture industry seaweed cultivation is the fastest growing aquaculture sector and provides huge potential for market growth in europe the red algae palmaria palmata is one of the target species of a growing european seaweed industry due to its high content of protein 2035 essential minerals and its appealing flavour recently there has been significant advancements in the aquaculture procedures for palmaria but these approaches are still mainly built on the utilisation of randomly collected wildtypes of palmaria a targeted strain selection has therefore huge potential to increase the prospects of palmaria aquaculture in europe the objective of the aspire project is to screen and characterise high yielding and robust palmaria strains this will be implemented utilising highthroughput phenotyping technologies using performance screening growth morphology characteristics and photosynthetic parameters and metabolomic analysis primarysecondary metabolites using gcms spectrophotometer nmr etc these results in conjunction with next generation sequencing illumina seq and bioinformatics tools tassel pipeline will be utilised to identify both biochemical and genetic markers of highyielding palmaria strains to ensure that the results have a high impact and find their way to the commercial enduser the project will establish a novel and easytouse webbased database mysql vuejs specifically designed for use by the aquaculture stakeholders the aspire project will conduct farmlevel trials to validate the advantages of growing the selected elite seaweed strains in terms of productivity and overall biomass quality the multidisciplinary project will set the bases for an urgently needed modern seaweed breeding programme to further develop the emerging european seaweed aquaculture sector
polluting steamships technology and environment in the european maritime world 1830s1920s

the impact of technological advance on the environment has become an essential topic in academic research and contemporary discourse the maritime transport industry has attracted plenty of attention yet the link between technological innovation in shipping and the rise of environmental and healthrelated issues among its workers is still largely unexplored in historical terms pollsteam proposes an innovative approach to maritime studies by adopting an environmental perspective on the transition from sail to steam in shipping since the mid19th century rethinking technological change in terms of environment and labour will reframe and readdress a recent research object of maritime history from an original angle sensitive to contemporary environmentalist and healthcare solicitationspollsteams objective is to examine how the advent of steam shipping altered european maritime societies from an environmental perspective two specific research subjects will be targeted waterfronts and seafarers in genoa and liverpool between 1830s and 1920 firstly i will analyse how the adoption of steam technology affected the natural and anthropic environment of port cities especially on the changing relationship between port and city where a constant detachment is observed port cities were materially transformed by the increasing presence of steamships not only in terms of space but also of environmental impact i will investigate how the cityport relationships were modified especially the role of institutions public opinion and urban society secondly steamships are regarded as working environments i intend to trace the emergence of environmentalist and healthrelated discourses among seafarers and to assess steam pollutions health impact on them which can be confronted with data on mortality and morbidity in the age of sail to reconceptualise with medical data the notion of steamships as deadly workplaces
respond to emerging dissensus supranational instruments and norms of european democracy

redspinel stands for respond to emerging dissensus supranational instruments and norms of european democracy it is an interdisciplinary and intersectoral research and innovation action bringing together 11 partner organisations from 8 european countries it will jointly analyse the changing nature of dissensus surrounding liberal democracy and its implications for eu supranational policy instruments redspinel will unpack the interconnected drivers of contemporary dissensus surrounding liberal democracy its findings will be rooted in theoretical innovation and original empirical analyses its conceptbuilding effort centered on the notion of dissensus will explore how contemporary dissensus surrounding liberal democracy differs from previous debates and which more fundamental questions it raises about future democratic practices and the rule of law ultimately redspinel will provide a typology of said dissensus map the principal actors of the dissensus in europe and unpack its two underlying drivers ie heightened internal contestation over liberal democracy and external competition from alternative illiberal models empirically redspinel will focus on the key policy instruments and legal mechanisms shaping the eus efforts in support of democracy and the rule of law the studied instruments include the eu rule of law toolbox the neighborhood and accession instruments the european semester fundamental rights and judicial instruments as well as citizen participation platformsfurthermore through a series of stakeholder events redspinel will flesh out the implications of its findings for public policy stakeholders ie legal professionals policymakers european youth as well as eu instruments aimed at responding to said dissensus the project will develop a range of scientifically informed policy recommendations and capacitybuilding efforts able to foster innovative democratic practices able to respond to the presentday dissensus
towards mxenes biomedical applications by highdimensional immune mapping

the longterm goal of mxmap is to develop a functional pipeline for the immune characterization of new 2d nanomaterials of mxene family for the qualitative and quantitative assessment of the human immune compatibility and immune activity towards biomedical applicationsthe immune characterization of the tested materials on the basis of intrinsic physicalchemical and immunological properties through the combination of the most innovative technologies such as singlecell mass cytometry cytof will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators scaffolds for tissue engineering cancer therapy and antibacterial agents mxmap will develop key chemistry and immunebased strategies for mxene medical applications the implication of this project extends beyond the specific nanoscience program greatly advancing the engineering process of 2d materials and their use in biomedicinethe mxmap project involves fourteen key players in european and noneuropean countries including the united states canada saudi arabia and three partners from ukraine coming from academia and smes this program will provide strong support for the development of the careers of young brilliant scientists who want to grow towards an interdisciplinary vision of science chemistry biology immunology engineering and cancer research are the expertise of mxmap the senior team members are among the most influential scientists including prof yury gogotsi hindex168 inventor of mxenes prof klaus ley hindex147 one of the most cited immunologists worldwide and prof husam n alshareef hindex99 the consortium is perfectly balanced in terms of equal gender presence the project coordinator lucia gemma delogu is a female and 2 out 4 of four wp leaders are female the project embraces a large view of inclusiveness and diversity including countries with smaller economies such as ukraine
distinguishing infantdirected speech and songs the distinctive evolution of acoustic features and visual entrainment in infants

given the immature cognitive abilities of infants at birth caregivers connect with them by producing stereotyped infantdirected id forms of speech and songs in which the acoustic features are modified although id vocalisations are fundamental for establishing social and affective bonds key aspects of infantcaregiver interactions are still poorly understood one of the goals of the musical speech project is to identify distinctive acoustic adaptations of id speech and songs by implementing machine learning models to crossculture recordings from diverse societies and track the evolution of those acoustic markers over the first year of life in addition recent evidence shows that the rhythm of id singing acts as an effective cue for infants to attend to emotionally and sociallyrelevant content such that infants look more to the caregivers eyes during onbeat moments of the songs this project aims to determine whether rhythm in id speaking similarly attunes infants attention and whether id speech elicits distinctive patterns of attention before and after 6 months as it serves more of a linguistic purpose using audiovisual recordings of adults speakingsinging to infants this project will implement cuttingedge eyetracking measures to samples of canadian and spanish infants finally prematurity and individual differences in neural coding of rhythm measured with a stateoftheart eeg paradigm can affect early interactions thus the eyetracking outcomes of terms and an additional sample of preterms will be correlated with the eeg signal elicited by rhythmic stimuli the crosslaboratory studies proposed in this innovative project will comprise training on advanced statistical techniques and leadership as they rely on the coordination of an international network the project can contribute to basic and applied fields with unprecedented highquality insights and an experimental paradigm shift to compare early language and music perception
transnational network of national contact points ncps for widening participation and strengthening the european research area

ncpwideranet aims at support the capacity and effectiveness of widera national contact points with a special attention to less experienced entities in low performing member states ms and associated countries ac to bridge the knowledge gaps to enhance access to funding possibilities under the framework programme through strengthening and enhancing the role of the ncps the project shall support international networking and coordination as well as improve the quality of proposals from legal entities from low ri performing ms and ac providing them with better access to services during the application process in particular with regard to widening participation and strengthening the european research area as well as pillar ii actions ncpwideranet will focus on identifying and sharing good practices within ncp community and raising standards of support offered by ncps to the applicants taking into account the diversity of actors that constitutes both the widening and era parts moreover this project will equip the transnational network of ncps to be in a better position to effectively address crosscutting objectives such as gender equality and open science
deciphering the roles of the salvage and de novo pathways of nucleotides metabolism in mitochondrial dna maintenance

mitochondrion is a crucial integrator of various cellular metabolic pathways in the intermediary metabolism and it has the ability to produce oxidativelyderived energy by the oxidative phosphorylation oxphos system the oxphos complexes are composed of subunits encoded by both mtdna and nuclear dna ndna and mutations in either class of genes can cause severe oxphos defects leading to mitochondrial diseases md remarkably the mitochondrion is unique among the cells organelles as it contains its own dna mtdna the deoxynucleotides triphosphates dntps required for mtdna synthesis are produced by the salvage pathway in the own mitochondrion however recent data suggest that de novo pathway for dntps synthesis is also critical for mtdna replication in fact defects in enzymes involved the de novo pathway have been recently reported as causes of md mitogarage aims to better understand how the different pathways involved in dntps metabolism work in mtdna replication and to develop therapeutic strategies when it is impaired this will allow us to better comprehend basic metabolic processes and their integration in pathophysiological and therapeutic aspects for md with that purpose we will use unique in vitro and in vivo models with defects in rrm1 guk1 and coq2 and a combination of modern and classical reductionist approaches mitogarage will be carried out in internationalrecognized groups at columbia university and the university of granada the workplan includes one key short visit to learn an specific technology training in basicclinic and publicprivate partnerships training in academic skills scientific and nonscientific workpackages tasks milestones and deliverables a contingency plan the landscape for results exploitation and the development of a career plan overall mitogarage clearly define the fourway transfer of knowledge and will achieve significant advances in the progress of the hyperpersonalized medicine
interfacemediated fast ionic conductivity in nanocomposite solidstate electrolytes

ion conduction in solidstate electrolytes sses is the bedrock of several electrochemical devices like batteries and fuel cells which are vital to our modern society high conductivity is crucial for such applications and increasing the intrinsically low conductivity of sses has been of enormous technological interest the discovery that the conductivity of sses can increase or decrease by orders of magnitude at their interface with a nonconductor eg oxides has led to much interest in the use of interface engineering to rationally design sses with improved conductivity and overall performance in electrochemical devices this has so far not been successful because the underlying mechanisms that lead to the profound changes in conductivity at interfaces are not yet well understood due to the complex composition of such interfaces and the fact that several properties of the two components concomitantly influence this effect building on my preliminary results i aim to unravel the fundamental mechanisms of interface ion conductivity by preparing model nanocomposite sses sse oxides that will allow me to disentangle the different parameters that contribute to this effect the interface physicschemistry responsible for interface ion transport will be precisely tuned via surface and compositional modification of the oxides i will combine advanced surfacesensitive probe techniques including xps xray raman scattering hrtemedx and nmr to study the interface compositions this will enable me to establish for the first time how the properties of sseoxide mixtures influence their interface reactions conductivity and performance in applications such fundamental insights will enable the design of novel sses with tailormade properties for a variety of electrochemical applications my extensive expertise and track record in nanocomposite materials sses and advanced materials characterization place me in the perfect position to lead this project
protein degraders for targeting galectin8

in the protag8 project we aim to target galectin8 by protein degradation using proteolysis targeting chimeras or shortly protacs galectin8 is a galactosidebinding lectin that exists as a soluble intracellular and extracellular receptor with an extensive exchange between the membranebound and cytosolic forms its inhibitors are potential new anticancer drugs but the affinity of classical galectin8 inhibitors is in the low micromolar range hardly sufficient for their use as drug molecules the overarching aim of protag8 is to explore whether the protac method can be implemented for galectin8 and to answer the question of whether protacs offer advantages over classical selective galectin8 ligands since protacs need only bind their targets with high selectivity and with an affinity high enough to stabilize the ternary complex between the protein of interest and the e3 ligase the affinity in the micromolar range could be sufficient for their activity unlike conventional ligands the current stateoftheart in the development of protacs focuses only on intracellular proteins but galectin8 exists as both an intracellular and extracellular protein based on this fact we want to find out whether such a receptor which occurs both in the cytosol and in the extracellular matrix can be effectively targeted with protacs and its activity modulated this scientific question will be tackled by a highlyqualified phd nives hribernik with international experience in glycochemistry medicinal chemistry and chemical biology and is expected to be an excellent springboard to her independent scientific career the project proposal includes renowned principal investigators from two academic institutions prof dr marko anderluh from the university of ljubljana slovenia and prof dr ulf nilsson and prof derek logan from lund university sweden giving the protag8 international and interdisciplinary background
identification of transiently formed immuneendogenous neural stem cell niches in spinal cord injury

despite endogenous neural stem cells enscs being present in the adult mammalian central nervous system cns their neuronal potential upon injury is rarely achieved in the brain and never in the spinal cord sc environment this makes widespread sc injuries scis especially challenging to treat even though sc enscs give rise to astrocytes oligodendrocytes and neurons in vitro they almost exclusively generate glial scarforming astrocytes seldom myelinating oligodendrocytes and never neurons in mammalian models we still do not know the exact sc niche cues preventing enscs from efficiently assuming oligodendrocyte and neuronal fates averting a functional sc healing notably sci induces a vast immune response and i hypothesise that immune cells that are responsive to the sci contribute to ensc niche formation where they can exert an effect on ensc regulation i will investigate this by unravelling o1 temporal heterogenous immune responses to the sci and o2 their spatial interplay with the enscs using advanced methodologies such as spectral flow cytometry and spatial transcriptomics this will enable me to identify which of these immune cells affect ensc gene regulatory networks leading to instigation of astrocyte but not oligodendrocyte or neuronal fates finally o3 i will identify scispecific enhancer elements of the immune cells of interest by comparing chromatin signatures of these immune cell types located across different tissues this knowledge will present a divide and conquer opportunity to compartmentalise and disconnect immune system across different tissues enabling a targeted immune cell manipulation specifically within the sci environment the longterm outcome of this project will help the design of enhancerbased immunomodulatory therapies to dictate ensc fates and generate oligodendrocytes and neurons in vivo leading to a functional sci recovery
direct measurements of collective swimming forces at the mesoscale

swimming is ubiquitous in nature and crucial for the survival of a wide range of organisms many swimmers move together in intricate swarms widely believed to save energy through collective hydrodynamic interactions while the physics behind swimming and swarming of viscositydominated microswimmers and inertiadominated macroswimmers has been extensively studied little is known about the intermediate regime 0110 cm where both viscous and inertial forces are important this mesoscale is full of living organisms such as small larvae shrimps and jellyfish and the physics behind their swimming and swarming is strongly complicated by nonlinear and timedependent effects at increasing swimming speeds and organism sizes a breakthrough in our understanding of mesoscale swarming dynamics is hindered by an absence of forcebased experiments on collective mesoswimming here i will perform pioneering experiments on the swimming forces of brine shrimps as model organisms i aim to discover how they adapt their motility in different environments and perform the first direct measurements on the binary and manybody swimming and hydrodynamic interaction forces within pairs and small swarms of brine shrimps i aim to resolve several major questions on mesoscale motility and swimming interactions with the grand goal to discover new insights into how and why swarms of mesoswimmers are formed in nature my experiments will open a new living matter physics research avenue at the mesoscale and provide sensitive and important force and fluid dynamics data for theorists to use in their future models and for engineers to use in their biomimicry design of new mesorobots the indirect impact of my work is the creation of new biomedical and engineering applications at the mesoscale such as swallowable surgery with swarming mesorobots capable of optimising their swarm geometry to minimise power consumption in different environments