Dragon09/odtu_chatbot huggingface dataset:
smart bioreactorbased platform for the multiphysical stimulation of engineered osteochondral tissues towards functional regeneration and advanced disease models

the incidence and socioeconomic burden of osteochondral oc diseases are growing worldwide representing a major challenge for the healthcare systems tissue engineering te emerged as a promising alternative to the current ineffective oc disease treatments however stateoftheart octe strategies are still unable to create functional engineered tissues mainly due to their inability to replicate in vitro the complex physicochemical environment of the native oc tissue within the articular joint making oc regeneration a critical unmet medical need the ambitious purpose of the synergies project is to fill this gap by developing a pioneering smart biomimetic bioreactorbased platform able to culture oc constructs under physiologically and clinically relevant multiphysical stimulations in a controlled and adaptive manner cuttingedge in silico modelling and machine learning ml tools will be employed for the operational parameters optimization and for the smart automated control of the bioreactor platform respectively the synergies platform will enhance the knowledge of oc tissue mechanobiology beyond the stateoftheart and guide the improvement of protocols for the production of functional oc substitutes which will be suitable in vitro models for oc disease research and drug screening paving the way for new effective therapiesthe proposed fellowship will enable a highly interdisciplinary collaboration between myself a talented postdoc with a strong track record on biomaterial scaffolds for octe and the supervisors leading experts on bioreactor engineering and in silico modellingml tools the excellent working conditions at politecnico di torino and 7hc will promote my professional development offering me new scientific expertise and leadership skills significantly widening my career perspectives ultimately synergies outcomes will be of remarkable benefit to the european biomedical sector contributing to eu excellence and quality of life
provable privacy for metadata

protecting users online behaviour is a challenging privacy problem in this project we will develop communication protocols for metadata privacy metadata is implicit information such as when and how many messages are sent and can therefore not be protected using standard encryption unlike encryption metadata privacy is not currently available in instant messaging services due to the impracticality of current protocols to protect users developing new practical protocols for metadata privacy is therefore essential moreover metadata privacy is a eu priority which will be regulated by the eprivacy regulation that is currently being drafted consequently protocols that guarantee metadata privacy for instant messaging needs to be designed to meet eus needswe propose a holistic project to address metadata privacy ranging from conceptual design to implementations of protocols in software by combining nelsons background in privacy and askarovs expertise in formal methods we expect to be able to tackle metadata privacy from a new perspective specifically we will design protocols that are provably private that is we will guarantee that our protocols are free from unintentional leakages in addition our protocols will be designed to be feasible to use on battery constrained devices such as phones
dissecting the role of the immune microenvironment in the onset of myelodysplastic syndromes

myelodysplastic syndromes mds are heterogeneous clonal hematopoietic stemcell malignancies of the elderly mds remain uncurable by existing pharmacological therapies aimed at eradicating mutant clones clonal cytopenias of undetermined significance ccus occur in elderly patients harboring mdsdriver mutations in their bone marrow cells and almost always preclude mds representing an optimal setting for studying the mechanisms driving the onset of mds in a preliminary study i discovered that innate immune cells from patients with ccus are transcriptionally rewired toward their activation but have signs of functional exhaustion and dysfunction therefore i hypothesized that dysfunctions in the immune microenvironment favor clonal expansion and disease progression in early stages of mds and therefore therapeutic approaches enhancing the immune response in ccus or mds patients may effectively prevent or arrest disease onset to test my hypothesis in this project i will dissect the role of the immune microenvironment in the expansion of premalignant clones in earlystage mds to do so i will 1 transcriptionally and immunophenotypically characterize the immune microenvironment in mds patients with low clonal burden at the singlecell level including interactions between immune and nonimmune cells 2 assess the functionality of the immune cell repertoire in ccus and mds patients through the analysis of their secretome and the cells secretory and cytolytic functions and 3 test the feasibility of targeting immune responses in mds by performing proofofprinciple drug testing assays with newgeneration immune checkpoint inhibitors and identifying and validating novel therapeutic targets i expect the results of this project to shed light on the cellextrinsic mechanisms eliciting mds pathogenesis and provide a biologic rationale for the development of pharmacologic or cellular therapies to prevent or earlytreat mds before outcomes become dismal
regenerative stenting for osteoporotic vertebral fracture repair

osteoporotic vertebral fractures ovfs are the most common complication of osteoporosis current treatment involves conventional procedures that inject cement into the vertebrae to stabilise the spine and relieve pain no reparative treatment exists biomaterialbased treatments have had very limited success due to a number of complex challenges such as providing dual therapeutic and mechanical functionalities to meet clinical requirements building on a wealth of experience in the area of materials processes we propose the solution restore will initially overcome the problems with traditional biomaterials approaches by utilising recent advances in the area of advanced manufacturing and 3dprinting to engineer a dual component biomaterial platform comprising of a 3dprinted biodegradable stent and a thermoresponsive hydrogel with mechanical properties and bioactive composition tailored to regenerate and repair osteoporotic vertebral bone following this and consolidating the research in the applicants lab on biomaterialmediated delivery of therapeutics to enhance bone formation and inhibit resorption the hydrogel component will be functionalised for the controlled delivery of antioxidant lanthanides to combat increased oxidative stress in the osteoporotic bone microenvironment and modulate impaired bone remodelling to drive bone regeneration and facilitate repair the restore technology has potential for use in a patient specific personalized medicine format as the 3dprinting process utilised allows for the stents to be tailored to the patients individual vertebra the hydrogels therapeutic load can also be adjusted and offers a potential minimally invasive prophylactic treatment for adjacent diseased vertebrae that do not yet require stenting a firstofitskind prevention strategy for ovfs the proposed restore platform is thus a paradigm shifting disruptive technology that will revolutionise the way damaged osteoporotic vertebrae are treated
building a european industrial supply chain for soi and sinbased silicon photonics including heterogeneous integration to support emerging markets

photonixfab brings together key european photonics and semiconductor players to establish a strong and sovereign european supply chain for silicon photonics the consortium leverages the volume capacity of xfab the european morethanmoore foundry and addresses the work program with six key objectives 1 transferring imecs worldrenowned silicononinsulator soi platform to xfab to achieve industrial manufacturing capacity the soi platform addresses a variety of highspeed and sensing applications 2 extending the industrial manufacturing capability of ligentecs silicon nitride sin technology at xfab to become the industry standard for sin photonics the lowloss and broad transparency of sin are perfect for sensing quantum computing amongst others 3 increasing maturity of heterogeneous integration with smart photonics indium phosphide inp active components such as lasers modulators and detectors these components are integrated on top of the soi and sin platforms by transferprinting this is an xfab associated technology forming a key innovation differentiator for photonixfab the leading european rtos imec and cea are supporting photonixfab with various technologies developed in horizon europe activities such as prototype transferprinting linbo3 modulators and ge detectors on sin 4 strengthening the european ecosystem with design automation luceda innovative packaging solutions phix and increased testing capabilities 5 demonstrating the viability of the new supply chain and technologies through six applicationoriented demonstrators in a wide array of markets 6 setting up pilot line and multiproject wafer access to serve innovation by startups smes and large entities and opening photonixfab for direct feedback on competitiveness and capabilities thereby the relationships between the supply chain partners and prospective endusers as well as between the photonics and the ecs worlds will be strengthened
micrometastructures for computational sensors with builtin memory

sensory input in integrated systems is expected to increase with the entrance of ai and internetofthings requiring systems to become efficient and autonomous the proposed research aims to introduce and study a new type of smart structure dubbed metastructures ms composed of repeating a unit cell to create a structure with new abilities such as multistability nonvolatility and configurability such structures can be used to design autonomous sensors with builtin memory and computational abilities allowing the formation of a new class of smart microelectromechanical systems mems with edge computation and inmemory programming imp in the aggregate such smart sensors can lessen the dependency on a cpu and increase the autonomy of an overall system while enabling distributed and parallel computations current memsbased structures are mono or bistable and as such are limited to registering one or two values in a sensormechanical memorylogical gate however recent studies have shown that an ms can break free from a twobit structure indeed in a recent breakthrough we have shown that in the presence of electrostatic actuation a microms becomes multivalued with three stable equilibria thus opening a gateway to a paradigm shift that goes beyond the study of new structures to the formation of new class of mems this new class of mems will be able to incorporate mechanicalbased computation with imp capabilities such an unconventional approach has the potential to augment traditional capabilities introducing new abilities such as reduced leakage and power consumption reconfigurability decreased footprint as well as compatibility with harsh environments ie high temperatures or electromagnetic radiation as well as reversible computing
goldmarie finanzen sustainable stock portfolios with modern riskreturn optimization

goldmarie finanzen gmbh is a women led green fintech which aims to offer sustainable investments to private people our future customers can invest online via our web platform all companies in our stock portfolio satisfy strict ecological and social criteria and diversified based on modern mathematical methods here the individual investment goal and risk tolerance as well as personal preferences in the realm of ecological and social goals are taken into accountthe two founders and ceos are highly qualified it specialists with expert knowledge in mathematics and computer science with goldmarie finanzen they develop deep tech solutions to a twofold problem on the one hand financial resources are needed for the green transformation on the other hand people would like to control the impact of their investment in a long tail business model goldmarie finanzen wants to make personalized stock instments which were formerly available only for major investors available to a broad publicwe utilize cuttingedge technologies from mathematical optimization and financial mathematics to build the individualized investment portfolios this includes automatic decision making and data science with profound mathematical quality controls the decision machinery is implemented based on modern software technologies and a custom data base that structures and connects relevant data from different sources with the women techeu grant we could enhance the portfolio decisions by including our customers opinions and knowledge about investment options an additional team member who is specialized in mathematical optimization and an experienced software developer would help to implement data flows and backtest tailored strategies during 6 months we could additionally fund marketing activities related to customer information and collecting the needed data mentoring and networking in particular with investors will grow the company and ensure future funding
kidney nephron orientation in vivolike in vitro

knovv aims at directing nephron spatial orientation within renal organoids to mimic in vivo kidney developmentchronic kidney disease ckd is an increasing socioeconomic burden with 100 million people affected in europe available treatments are limited to dialysis and transplants tissue engineering and regenerative medicine term aims at developing in vivolike organs using in vitro threedimensional 3d systems as new therapies promising term therapies involving selforganized renal organoids from human induced pluripotent stem cells hipsc are being investigated these kidney organoids contain the appropriate cells although heterogeneity immature stage and lack of the spatially specific nephron orientation are still major bottlenecks these limitations impair microphysiological form and function which limits their research utility and clinical applications i hypothesize that inducing spatial nephron orientation in kidney organoids will result in improved maturation and function closely mimicking the in vivo organ to achieve this i will optimize protocols to generate renal organoids from hipsc i will identify molecules to inhibit or induce glomerulogenesis glomeruli formation and develop glomerulogenesisinducing and inhibiting hydrogels for bioprinting renal organoids immunostaining qpcr and functional assays will be used to evaluate the morphology and function of the 3d bioprinted renal organoid construct knovv will strengthen my research and academic profiles broaden my knowledge and experience by combining developmental biology term and biofabrication to improve renal organoids my ambition is that the bioprinted renal organoid constructs with spatially directed nephrons will enable unprecedented microphysiological maturation and function this will allow a leap beyond the current organoids state of art and ultimately lead us closer to clinical translation offering an alternative for the growing ckd population
gestalts relate aesthetic preferences to perceptual analysis

de gustibus et coloribus non disputandum est with this slogan philosophers and lay people alike have dismissed all attempts to understand taste color perception or aesthetic preferences sense of beauty may just be too individual and too complex to qualify as target of scientific inquiry yet since fechner 1876 empirical aesthetics has studied the factors determining peoples aesthetic responses to art works and objects scenes or events encountered in everyday life most accounts focus either on highlevel concepts such as style meaning and personal associations or on lowlevel statistical properties while the latter are supposed to be universal and biologically determined the former are subject to cultural influences art expertise and individual experiences progress in this tradition has reached its limits which this project overcomes by investigating how gestalts relate aesthetic preferences to perceptual analysis grappa its pioneering working hypothesis is that the way perceivers organize their sensory inputs into meaningful entities gestalts provides the missing link between the two traditional sets of explanations this hypothesis is fleshed out and tested in a coherent research program linking aesthetic preferences for images of paintings and everyday photographs to general principles of perceptual organization as well as to specific aesthetic concepts like composition balance and visual rightness new data from online studies with large samples of images and participants will be analyzed with stateoftheart computational methods machine learning to reveal the critical midlevel factors this will yield a model to predict aesthetic preference which will be tested in wellcontrolled psychophysical and behavioral experiments eg eyemovement recording and validated also in ecologically richer settings eg in galleries and art museums and in unconventional crossover collaborations with contemporary artists
hidden legacies how discontinued international organizations have shaped european governance since the 1910s

what happens after international organizations ios cease to exist while ios ends are occasionally discussed in political science and legal studies we know very little about the legacy of ios and hence the subsequent role and impact of people ideas practices and objects including buildings and budgets that once filled such organizations with life and meaning inecho hypothesizes that for a full understanding of international history and questions of political governance more broadly it is indispensable to consider the legacy and impact of liquidated ios new beginnings frequently echo the work of earlier ios even if existing interpretations and narratives ignore or downplay such links using largely neglected public and private sources as well as interviews inecho will break new ground for international and european history by focusing on the afterlives of european international organizations since the 1910s it highlights five empirical casestudies representing the whole spectrum of possible options informed by and contributing to an interdisciplinary state of the art inecho builds on an innovative set of concepts and methods to address these issues inecho will thus establish a new conceptual framework that will help research to rethink the nature of international cooperation and internationalism its approach and its findings are also highly relevant for the analysis of other world regions and their international history and for audiences beyond academia
unveiling the molecular basis of chromatinopathies to delineate innovative therapeutic solutions

chromatinopathies cps are a group of rare genetic diseases which share clinical features as well as causal genetic alterations leading to the inactivation of chromatin regulators involved in gene expression control and 3d chromatin organization within the framework of chromrare we will focus on a group of clinically welldefined cps including kabuki syndrome charge syndrome rubinsteintaybi syndrome and cornelia de lange syndrome although the causative genes for these cps have been identified the consequences of their inactivation both at the molecular and functional level have not been defined the clinical features of cps vary widely suggesting that the impact of the haploinsufficiency of the affected chromatin regulators could depend on the epigenetic state andor interactions with additional genetic and environmental factors hence understanding the genetic and epigenetic determinants of cps represent an immediate medical need as this will ultimately facilitate reaching the development of new therapeutic approaches our main goal is to setup an intrasectoral crossdisciplinary training programme that would prepare the next generation of researchers equipped with advanced theoretical technical and computational skills to study fundamental aspects of chromatin biology and their impact on cps in parallel chromrare will devise new strategies to translate the molecular findings into new diagnostic and therapeutic approaches for patients affected by cps to enable understanding the molecular basis of chromatinopathies we aim at developing multiple disease models recapitulating the main clinical features of cps wp1 investigating the genetic epigenetic and topological determinants of cps wp2 and uncovering perturbed regulatory circuitries suitable for therapeutic intervention wp3 overall chromrare will address unmet socioeconomic medical and scientific needs for the understanding and possible treatment for cps
unpacking paradigmatic gaps

universal paradigmatic gaps are gaps in linguistic paradigms that appear across languages and across users of a given language as of yet only very few gaps of this kind have been discussed in the literature the one gap that has received substantial discussion concerns the universal absence of a lexicalized negated form for the quantifiers all every or always there appears to be no language in the world that exhibits a single word or lexical item that means not all not every or not always an observation dating back to thomas aquinas 12251274 unpag will show that the landscape of universal paradigmatic gaps is in fact much richer and more varied than generally thought of it is deeply enigmatic that such words do not exist across languages and cultures clearly any theory seeking to explain such missing lexicalizations ie any theory of universal paradigmatic gaps should be able to make clear predictions about what may or may not be lexicalized and why that is the case such a theory has thus far not been developed it is also without question that such a theory should have a broad empirical foundation to date the pool of data has been heavily slanted toward wellstudied western indoeuropean adult spoken language and negative quantifiers therein no existing study has thus far come even close to targeting a richer empirical base even though many more universal gaps can be observed unpag will be the longoverdue filler of this gapunderstanding the nature distribution and behaviour of universal paradigmatic gaps will have several profound implications for our understanding of human cognition language and communication unpag is the first panoramic study of universal paradigmatic gaps why is it that we cannot always say what is thinkable unpag will provide an answer to this question and show when how and why universal paradigmatic gaps may emerge in the languages that we speak or sign
a fully wearable electrostimulating system designed to improve mobility and foot health in diabetic peripheral neuropathy patients

the neurosock is a noninvasive fullywearable device designed to induce sensations in patients with sensory loss due to conditions such as amputation diabetes or multiple sclerosis the device captures information from the environment interaction through wearable sensors and translates it into electrical impulses delivered to the nerves embedded in a softrobotic stimulating garment an aibased algorithm optimizes stimulation parameters to target the nerves and restore natural sensation to patients in realtime our device has been already validated in 12 neuropathy patients resulting in 30 restoration of lost sensation in the foot and in an improved cadence in 60 of the users the generated artificial feedback intuitiveness was validated through an fmri study this ercfunded project aims to investigate the health benefits of neurosock with the potential to improve skin conditions lower cardiovascular stress and ultimately reduce the harmful conditions that lead to sedentary lifestyle heart failures amputations and elevated death rates therefore the funding will be used for optimizing the neurosock design for homeuse scenarios and a following clinical trial investigating the longterm rehabilitative effects on people suffering from neuropathy who currently have no immediate solution