Dragon09/odtu_chatbot huggingface dataset:
the african origins of western canon law an investigation into the corpus canonum africanoromanum

in the proposed project i aim to prepare a comprehensive study of the most important north african collection of canon law the late antique corpus canonum africanoromanum ccar which is also the oldest known canonical collection of the western church this collection is of fundamental importance because 1 it had greatly impacted the development of occidental canon law on a textual level to name but a few collections hispana dionysiohadriana the hispana gallica augustodunensis and the decretum gratiani 2 it had a longlasting impact on the perception of africa in medieval western europe because its textual material was extremely widely disseminated and used across the continent canon law texts are not only sources of legal history but they can be evaluated as sources of historiography and social history as well the ccar is a prime example for how texts have been selected reshaped and adapted by later generations these observations also lead to several questions which shall be addressed to what extent is the ccar transmitted in mss alongside texts of african church fathers what documents have been revised when copying the ccar which african texts have been omitted rearranged annotated has the legitimacy and authenticity of the african canons been contested or doubted in later periods what role did africa play in the imagined landscape of western christianity and latin canon law as ties between western europe and north africa had become severed did it follow that the now essentially decontextualized african material could be reinterpreted or even manipulated for ones own purposes in other words in what ways does the textual shape of the ccar derive from later scribes and compilers making liberal use of the past on the basis of the ccar i will set out to to trace and evaluate the reception of selected north african canons both within the broader context of western canon law and in the context of societal processes defined by it
targeting cancer with multiengineered selenium nanoparticles senps development of a biocompatible nanocomposite for targeted gene therapy in brafmutated resistant melanoma

nanotechnology has grown at an exponential rate in the last decade finding a large application in the biomedical field nanoparticles are emerging as effective drug delivery tools since they overcome most limitations of free therapeutics while offering a series of physicalchemical advantages among engineered nanomaterials selenium nanoparticles senps have shown a growing potential as a therapeutic platform since they offer both the properties of selenium se and the ones of a nanoscale system sunset project aims is to design and develop a hydrogelbased nanocomposite containing multifunctionalised senps to use as an effective nanoplatform for cancer gene therapy the designed system will be evaluated in resistant melanoma specifically braf mutated lesions which represent 66 of the cancer cases and are those that show resistance to currently available therapies causing most cancer deaths here the synthesis of senps is followed by surface functionalisation with a specific small interfering rna sirna and their embedding in the polymeric phase all the materials will be synthesised through green chemistry routes to guarantee a low environmental impact of the procedure and its scalability and reproducibility the anticancer activity of the nanocomposite will be evaluated both in vitro and in vivo overall the combination of rnai technology nanomedicine and biocompatible materials selenium and natural hydrogels will be useful to gain a more efficient therapy overcoming the main current challenges in the care of resistant melanomas moreover the simplicity of the fabrication and the possibility to scale up the procedure make the proposed system possibly attractive for clinical applications promoting european scientific excellence lastly i will have the possibility to start new crossdisciplinary collaborations that will pave the way for my future research career
coupling volcanotectonics numerical modelling experimental constraints and volcanic thermal emissions to unravel crustal magma migration

volcanic eruptions can have catastrophic consequences to the planet or to nearby residents and infrastructures although our understanding of magma ascent and volcanic eruptions has vastly improved in recent decades many aspects of magma transport in earths crust elude us such that incomplete interpretation of signals monitored during magmatic unrest prevents the development of robust models to track magma transport and forecast the timing and location of volcanic eruptions hence new efforts are needed to integrate volcanic structures with novel remote sensing monitoring techniques and cuttingedge laboratory measurements to develop comprehensive models of magma transportcaravaggio aims to develop and validate an innovative interdisciplinary thermochemicomechanical tcm numerical model to simulate magmatic dike propagation the tcm model will permit the integration of realistic volcanotectonic structure lithostratigraphic heterogeneities local faults etc laboratory constraints of geomaterial properties strength permeability thermal properties fluid and heat transfer from magma into fractured rocks and spaceborne ground temperature measurements these multiparametric constraints will increase the robustness of modelled outputs to improve constraints on the conditions leading to magma transport and eruptions the model will be applied to the ongoing 2021present fagradalsfjall eruption southeastern iceland which has been thoroughly monitored using groundbased and satellitebased instruments and which has been cored in nearby boreholes by geothermal companies thus providing an unparalleled level of data to validate the model outputs the model will be shared with the community via strategic dissemination activities and scientific achievements will be shared with the public ultimately the outcomes of caravaggio will enhance future efforts aiming at forecasting the timing and locations of volcanic eruptions
leveraging the european compute infrastructures for dataintensive research guided by fair principles

in the past decade many scientific domains have been transformed into datadriven disciplines relying on the exchange and integration of internationally distributed data exploiting this data is still a laborious and largely manual task prone to losses and errors and increasingly specialised beyond most users technical capabilities fair practices are encouraged but their adoption curve is steep the needs for compute and data resources tools and application platforms are often domainspecific many scientists struggle to navigate this intricate ecosystem generally researchers do not possess the computing skills to effectively use the hpc or cloud platforms they need thus new approaches are needed to enable all researchers with widely ranging digital skills to efficiently use the diverse computational infrastructures available across europe for asynchronous and for interactive applicationseurosciencegateway will leverage a distributed computing network across 13 european countries accessible via 6 national userfriendly web portals facilitating access to compute and storage infrastructures across europe as well as to data tools workflows and services that can be customized to suit researchers needs at the heart of the proposal workflows will integrate with the eosccore adoption development and implementation of technologies to interoperate across services will allow researchers to produce highquality fair data available to all in eosc communities across disciplines life sciences climate and biodiversity astrophysics materials science will demonstrate the bridge from eoscs technical services to scientific analysiseurosciencegateway will deliver a robust scalable seamlessly integrated open infrastructure for datadriven research contributing an innovative and customizable service for eosc that enables operational open and fair data and data processing empowering european researchers to embrace the new digital age of science
precision medicine platform in neurodegenerative disease

neurodegenerative diseases are one of the most important contributors to morbidity and mortality in the elderly in europe over 14 million people are currently living with dementia at a cost of over 400 billion eur annually comorbidities with these conditions are frequent and a major obstacle to optimal diagnosis and management recent advances in diagnostic technologies and the advent of diseasemodifying therapies dmt for alzheimers disease ad the most common aetiology of dementia heralds the beginning of precision medicine in this disease area prominent will develop a digital platform for precision medicine that will remove barriers that currently exists for leveraging these technological advancements in the routine care of patients with neurodegenerative disorders and comorbidities the platform gives clinicians access to prediction models leveraging multimodal diagnostic data automatically derived from multiple sources imaging repositories medical records mobile devices helping them choose optimal care pathways and improving diagnostic precision it will provide personalized relevant and meaningful information on diagnosis and prognosis in a format understandable by patients and care partners further it will support the introduction of new health technologies such as dmt for ad by ensuring adherence to appropriate use guidelines and facilitating the prospective collection of data on realworld usage safety and effectiveness the expected impact of the project is to increase diagnostic accuracy and optimized use of existing and new treatment options it will empower patients and caregivers by engaging them in more personcentric health care decisions leading to improved adherence and patient experience ultimately this is expected to lead to costeffective care improved health outcomes and quality of life
quantum internet alliance phase1

the mission of the quantum internet alliance qia is to build a global quantum internet made in europe by developing a fullstack prototype network and by driving an innovative european quantum internet ecosystem capable of scaling the network to worldleading european technology building on its proven track record in teamwork which has already resulted in world first quantum internet technology qia advances this mission in two complementary objectives the first is the realization of a fullstack prototype network able to distribute entanglement between two metropolitanscale networks via a longdistance backbone 500 km using quantum repeaters the second is the establishment of a european platform for quantum internet development which will act as a catalyst for a european quantum internet ecosystem including actors all along the value chainqias network will enable advanced quantumnetwork applications and prepare the ground for secure quantum computing in the cloud thanks to our new generation of end nodes including both processing nodes and lowcost photonic client devices nodes in the metropolitan network will be interconnected via hubs that allow the scalable connection of hundreds of end nodes paving the way for early adopters the longdistance backbone will be realized using fully functional quantum repeaters unlocking paneuropean endtoend quantum communication qias prototype network will operate on standard optical fibers and serves to validate all key subsystems ready to be scaled by european industryin this first sga we will advance towards the longterm objectives set up in the fpa project here we present in detail how work will be implemented during this first phase of the sga
urban frontiers from illegal land occupation to legalized property

no land that government and developers see as future cities in the global south is vacant there is no empty nomans land individual citizens social movements squatters and urban developers already engage in making their land use look legal urban property development in the global south often starts out in illegality only subsequently does it become legal this project explains howmainstream research on the global south sees urban land in technical terms of rapid urbanization and the challenges of providing sufficient housing infrastructure and service yet if we fail to understand the significance of institutional transformation of urban land we will not understand the future political landscape in the global south as landed property is the pivot around which government and citizenship turn with this project i develop and combine two new concepts to explain how people and not just the state code access to land and then conjure up legality for facts already existing on the ground coding is rulemaking whereas legalization gives a rule the quality of law a rules quality as law is not intrinsic to the rule itself but something attributed to it in social and political interaction governments make laws but the originality of the present project lies in determining how multiple actors aim to make their land claims appear legal as if they were sanctioned and approved by state and lawmy team and i will collect material evidence record artefacts from archives material structures physical markers and signs boundaries and documents and other expressions not produced directly for us and ethnographic testimonies from residents land users civil servants lawyers politicians and developers to establish how illegal land use is made to look legalnine conflictscase studies will be conducted in periurban areas of cities in asia africa and latin america by 1 prof pi 3 assoc profs 3 postdocs and 3 phds
european network in coding theory and applications

coding theory is a cornerstone of the mathematics of communications it an interdisciplinary field lying at the intersection of mathematics computer science and electrical engineering it is a fundamental tool of every system of digital communications with applications to errorcorrection distributed storage wireless communications secure multiparty computation and postquantum cryptography the encode doctoral network will focus on fundamentals and applications of coding theory to security privacy and efficiency of distributed communication computation the dn will leverage the complementary expertise of 7 academic and 5 nonacademic partners to guide its 8 dcs to address and solve deep problems in coding theory and its applications the dn will offer a superior supervisory experience for each dc who will each benefit from the expertise of multiple advisors in academia and industry the nonacademic partners include 5 companies working at the cutting edge of cybersecurity who will offer invaluable contributions to the training programme via hosting of dcs and input in advanced training sessions dcs will be exposed to current technical challenges faced by industry and will have the opportunity to apply mathematics to tackle realworld problems during industrial secondments encode will create a unique training programme designed to equip its dcs with the scientific tools and transferable skills required for them to become future leaders in the field both in academia and in industry the encode programme will implement all ec principles for innovative doctoral training adhere to best practice as outlined in the eu charter code the msca green charter and ensure gender equality in all aspects of its activities to create a lasting international intersectoral interdisciplinary doctoral network dedicated to excellence in science ethical standards communications that will extend far beyond the dn
recycling technologies for elv components to create a sustainable source of market grade materials for eu applications

crusade upscales novel technologies to trl7 integrated in a universal hydrometallurgical method to recycle up to 500 tnyear of spent automotive components autocatalysts fuel cells batteries and printed circuit boards from endoflife vehicles and recover ca 40 tnyear of critical raw materials cu c co mn ni pt pd rh li ru at commercial specifications the project leverages predeveloped technologies to establish a market ready pilot unit utilising novel concepts for material tracing using blockchain ako saislab ente and pan european collection network establishment from the pioneers of the automotive components manufacturers sun adv crf mono acu which guarantee the long term sustainable operation of the unit the material processing covers the whole chain from pretreatment using validated technologies from the experts on the crms recovery mono tubaf kul and upstream processing using a microwave assisted leaching methodology enabling a 1580 lower co2 emission process depending on the feed compared to commercial processing high specification market ready materials are prepared as outputs of the project undergoing a downstream purification and recovery process using solvent extraction and electrowinning guided by industrial standards for enduse applications while validated and benchmarked during the course of the project in new automotive products the processing is automated aiming to a 15 time reduction compared to current processes with the use of an industrial robot and artificial technology guiding the sorting and the hydrometallurgical treatment industry 40 concept the materials are commercialised at 15 lower price compared to market standards due to the automated innovative cost efficient processing capexopex reaching max 70 of product cost average 30 gross profit margin depending on feed
secretariat of the european technology and innovation platform on renewable heating and cooling in 20222025

this proposal aims at supporting the work which has been carried out by the secretariat of the european technology and innovation platform on renewable heating and cooling since 2009 the role of the secretariat is to assist the stakeholders of the rhcetip in coordinating activities related to the implementation of a research and innovation strategy to increase the use of renewable energy sources for heating and cooling in line and supporting the targets set by the european green deal as well as to foster the growth and the market uptake of the rhc technologies the secretariat provides support to the structure of the rhcetip by organising meetings events and relevant consultations and by assisting with the preparation of relevant documents both of technical and of political nature to raise the profile and importance of the renewable heating and cooling sector and its related technologies it also provides consensusbased strategic advice to the setplan and will play an active role in the planned update of the setplan in 2022 this proposal keeps the emphasis on the need to enlarge the membership of the rhcetip by involving more closely policy makers and rhc stakeholders on the national level as well as other relevant stakeholders ie new markets for the hc demand side and socioeconomic experts in its work this proposal adds stronger emphasis on the rhc industry through establishment of rhc accelerator and the development of the rhc industrial strategy by supporting interactions between the many stakeholders representing industry research and academia from different renewable heating and cooling technologies and by further inclusion of complementary sectors and expertise the secrhcetip will assist the rhc sector in strengthening its growth and competitiveness both visvis traditional heating and cooling technologies as well as with respect to other res energies and competitors coming from noneu countries
ngi0 entrust

ngi0 entrust is a unique program to foster open source and open hardware solutions to pervasive privacy and data governance problems in internet technology ngi0 entrust leverages the proven successful ngi zero program to fund internet research and development projects with a lightweight granting procedure and orthogonal support services to address internetscale requirements ngi0 entrust extends this program to contribute to more trustworthy data management tools and decentralized identity management solutions by supporting a european ecosystem of top internet innovators many of which we expect to be groups of individuals previously not funded by horizon europelike rd initiatives ngi zero has 95 grantees not previously funded by h2020 we expect to leave a lasting impact on the field of online data and identity security and privacy because we can build on decades of experience to make this happen what is unique about our program is that we provide an agile effective and low threshold funding mechanism coupled with a greenhouse environment where funded projects in addition to receiving a grant are supported by world class domain experts in various fields such as security accessibility license compliance etcetera the experts participating in ngi0 entrust provide guidance and mentoring to tackle each of these topics and meet important requirements and needs of technologies on internetscale and to directly connect project output to decision makers we can leverage our close ties to major constituencies major standardization bodies ietf w3c oasis the largest european open source community and open source licensing experts fsfe the digital rights and civil society actors edri eff internet society the hosting companies eco industrial and hardware representatives and gatherings osadl fossi and operational and technical intermediaries euroix ripe centr gant euroispa together we can make a more trustworthy internet
the telosome deciphering the architecture of the shelterin complex and its network

telomeres of eukaryotic chromosomes are protected by the shelterin complex the human shelterin is a sixsubunit protein assembly trf1 trf2 tpp1 pot1 tin2 rap1 this complex associates with telomeric dna and prevents the mistaken detection of the telomeres as double strand breaks by the dna damage response ddr machinery illicit dna repair at telomeres results in cell cycle arrest and endtoend chromosomal fusions or other improper recombinations causing genome instability the abrogation of the shelterin assembly or subunit removal decompacts the telomere and causes ddr accumulation defects in the shelterin complex are associated with telomererelated pathologies such as cancer and aging the suprastructure of the mammalian shelterin complex remains unknown therefore we lack fundamental knowledge regarding its organization and functionthe shelterin complex also acts as a signalling hub recruiting accessory factors that participate in telomere homeostasis and maintenance and shelterin subunits are subjected to posttranslational modifications ie ubiquitination phosphorylation sumoylation however the functional role of these modifications is not fully understood the overarching aim of this project is to solve the atomic structure of the human shelterin complex by cryoem and elucidate the molecular events of telomere biology during the cell cycle combining cellular and proteomic approaches the outcomes will provide the first structure of the shelterin complex and the shelterin interactome which will allow to understand defects underlying pathology at molecular level and join this information to physiologic and phenotypic data this project will have a substantial impact on my career as new skills in biophysics structural biology and proteomic techniques on human macromolecular complexes will complement my previous expertise in xray crystallography biophysics and biochemistry on bacterial and viral proteins