Dragon09/odtu_chatbot huggingface dataset:
silicon and t2sl european collaboration for a nondependent supply chain for large eswir fpas

in the last years mercury cadmium telluride mct ir focal plane arrays fpas have drastically boosted the observational capabilities of space ir payloads in the us industrial production of mct ir fpas with formats up to 4k4k pixels is established while in europe initiatives from european institutions and most advanced eu manufacturers are currently ongoing to progress on large format mct hybrids such as 2kx2k though the industrial setup necessary to support operational space programs remains to be elaborated and matured as instruments designers are asking for larger size fpas eu detector manufacturers are losing ground with respect to us competitorst2sl technology is an alternative to mct for the manufacturing of ir fpas in the us progress on t2sl fpa development led to up to 8k8k ir fpas demonstrations but like us mct ones these are not easily available for the eu market due to strong exportitar restrictions moreover us roics feature better performances and interfaces compared to their eu counterpartsthe step project will provide a disruptive european supply chain fully focused on the design and manufacturing of competitive and affordable large format t2sl eswir fpas step will incorporate all steps of the ir fpa production chain detector design large scale growth fabrication hybridization large format and high performances scalable roic with dedicated features to improve eswir space fpa performances and evaluation of large space prototype fpas including space environment evaluationstep will benefit from a european complementary consortium team airbus the wellknown space industrial requirements performances testing environment evaluation space missions insertion and business plan the european leader in t2sl manufacturing irnova high performances eswir t2sl design characterization fpa space prototype manufacturing and nonspace applications insertion a world class rto fraunhofer iaf t2sl manufacturing and characterization and a leader in aerospace research isaesupaero high performance large format roic design validation and establishment of a eu large format digital space roic line
alkaburst20 a game changing bioreactor for sustainable production of active pharmaceutical ingredients in a consistent traceable and low cost approach

alkion a revolutionary biotech company is developing a breakthrough biorefinery to produce top quality active pharmaceutical ingredients api and extracts in plants in a sustainable and costeffective way our core technology combines our disruptive patented automated bioreactoralkaburst20 with unique knowhow on gene expression methods culture media and extraction our process offers high productivity and a low carbon footprintthe pharma industry is carbon intensive with recurring problems of quality safety moreover many critical apis are outsourced to asia to cut costs alkaburst20 allows a local standardised production of safe clean apis in its automated process saving 75 time 80 space 95 electricity 98 waterwe first validated the production for covid19 natural vaccine adjuvants qs217 cannabinoids certain recombinant proteins for the urgent market demand we need 75m to build validate our pilot and expect to generate 125m revenue by 2028 with 105 job
acute pancreatitis therapy by ror activation and fgf21 expression

pancreatitis in humpancreatitis in humans is a cause of significant morbidity and mortality acute pancreatitis events have increased worldwide over the last 20 years at an average annual percent change of 3 and the economic burden is growing 1 treatments for pancreatitis are currently limited the overall mortality rate in acute severe pancreatitis is 1015 thus a specific treatment for pancreatitis is of great need recent reports suggest that fgf21 can ameliorate acute pancreatitis in mice fgf21 is a protein which belongs to the fibroblast growth factor family and is predominantly produced and secreted by the liver fgf21 is positively regulated by the ror transcription factor i will assess whether a ror agonist that we identified by screening compounds that act against nonalcoholic steatohepatitis nash in mice and which we found to increase fgf21 expression can be used to treat acute pancreatitis 2 in addition we will also investigate whether increased fgf21 expression can be used to prevent pancreatitis triggered by endoscopic retrograde cholangiopancreatography ercp we established the caerulein and alcohol induced pancreatitis models in the caerulein model we show unpublished and patented us pending patent 11865090 significant therapeutic effects of a small compound that activates ror in this poc we intend to explore new compounds of the same family with better efficacy on fgf21 in vivo and improve the treatment for acute pancreatitis this study will establish fgf21 as a prognostic biomarker for acute pancreatitis in humans by plasma elisa and circulating free dna this poc project has the potential to achieve a breakthrough therapeutic treatment for acute pancreatitis one that is commercially viable effective avoids an immune response and has the benefits of a natural delivery a natural chemical composition of fgf21 lower cost higher availability simple storage and overcomes the short halflife of synthetic proteins
master framework and pragmatic clinical trial for relapse or refractory acute myeloid leukemia

in impactaml a multidisciplinar rr aml represents a model of highimpact disease in which no standard of care exists and where we have an urgent need for new evidence on possible therapies aml offers the setting in which methodological innovation will combine powerful instruments of clinical trials with personalized medicine through academic efforts hereby we propose to create an inclusive master framework for relapsed or refractory acute myeloid leukemia stream to include patients with rr aml across europe proficiently acquire an unselected population for clinical trials and monitor outcomes including neglected cohorts thereafter we will conduct a prospective randomized pragmatic clinical trial rpct that will compare the classical high intensity rescue chemotherapy with biologydriven low intensity rescue to obtain real world data on the benefit of one of the two different strategies in term of survival also considering patients and caregivers preferences patientreported outcomes pro accessibility affordability and social cost rpct will aim to evaluate the effectiveness of realworld clinical alternatives in routine care in addition to retaining the high internal validity of traditional randomized trials it will maximize external validity i e generalizability of results to many settings in this context the inclusion of an rpct in the master framework will allow a dynamic inclusion and the collection of the excluded population as an instrument to predict the reallife applicability of clinical trial results we will offer europe results from an ambitious project that will go beyond the state of the art in rr aml demonstrating the superiority of a strategy in a firstofhiskind clinical trial providing strong data that will be delivered to national health care providers policymakers and health authorities data on optimized and affordable treatment for rr aml and promoting the implementation of the selected better option this action is part of the cancer mission cluster of projects on diagnosis and treatment
circular and biobased solutions for the ultimate prevention of plastics in rivers integrated with elimination and monitoring technologies

upstream addresses the targets of the mission by overcoming challenges related to the monitoring prevention elimination and valorisation of litter l plastics p and microplastics mp demonstrating a suite of 14 solutions addressing pollution at every step in the water system connected to 7 rivers in 5 countries will enable the cocreation of an extensive database of knowledge and sustainable business models with a focus on making information as widely accessible as possible the involvement of wastewater treatment plant wwtp owners industrial partners with existing supply chains innovative smes and a water cluster association will ensure exploitation of the project solutions while 500k in cascade funding will enhance replication across europe the upstream consortium will thus establish circular value chains with the potential to decrease plastic litter by 50 and mp pollution by 30the advances in upstream are based on bestinworld innovations including standardised rapid monitoring techniques able to detect mp down to sizes 25 m biobased biodegradable plastics the stop the formation of mp in consumer products and wwtps themselves elimination of more than 90 mp within wwtps from both sludge and effluent streams innovative floating platforms capable of removing 83 of l p and mp directly from rivers at both the surface and riverbed without creating noise pollution or harming ecosystems production of relevant monomers from recovered plastics through both advanced fractionation and depolymerisation and biotransformation upstream represents a paneuropean consortium with 5 demo sites across europe including 4 wwtps uk es de it plus a testing area on the danube in serbia the consortium is strengthened by top european rtos the world leader in sustainable bioplastics development novamont and completed by partners dedicated to creating a digital knowledge sharing platform and engaging with citizens and stakeholders
precision synthesis of magnetic graphenoids as room temperature twoqubit systems

quantum computing technologies face a fundamental challenge of scalability primarily due to the lack of materials capable of performing errorfree quantum operations at room temperature molecular graphenoids mgs have displayed superior quantum properties at room temperature making them an attractive alternativethis project will bring novel magnetic graphenoids with atomic precision through scalable solution wet chemistry and study them as twoqubit systems at room temperature this proposal will also uncover the suitability of the spin arrangement ferromagnetic or antiferromagnetic in mgs as qubit systems with implications for future developments in the field of molecular quantum materials in the second part the project focuses on increasing the spin coherence time one of the key parameters for quantum operations at room temperature this will be achieved through structural tuning of mgs to minimize the spin decoherence channels the overarching goal of the proposed work is to introduce new graphenoids as twoqubit systems answer a fundamental question and use the new knowledge generated to tune the respective mgs to achieve a spin coherence time 100 s at room temperature bringing a major advancement in the fieldthe proposed study will be of critical fundamental and practical significance by providing novel graphenoids with potential applications in future quantum technologies the nature of the proposed project is highly interdisciplinary involving chemistry physics molecular magnetism and material science the project is in line with the european objectives of sustainable industrial growth and climate change mitigationmy supervisors prof feng and prof bogani have the experience and resources to effectively supervise me and ensure the success of the msca action the fellow will get substantial career enhancement opportunities for future leadership roles through skills development and extensive training
documenta coranica byzantina docobyz byzantinoislamica in the age of digital humanities

to understand the evolving role of islam in europe it is important to comprehend the forms and contents of intellectual exchange between the latin and byzantine world research to date has mainly focused on the latin impact on the christian perception of the quran and islam documenta coranica byzantina docobyz will address a significant research gap by diachronically exploring greek translations of the quran and antiislamic argumentation in byzantine polemics 7th13th century before the first latin translation appeared 12th century this way it will be possible to synchronously compare their possible impact on the later latin traditiondocobyz will trace the exact transmission lines of i the greek quranic translations testimonia coranica graeca in order to ii document their reception and reuse within greekorthodox polemics episteme islamica orthodoxa and to iii distill diachronically the common topoi and stereotypes of antiislamic argumentations as well as to synchronously study them with the pre12th century latin translations traditio islamica medievalisthe project is based on a genuine interdisciplinary approach it combines greek latin and arabic philologies with paleographical historical and theological work and methods of digital humanities docobyz will create big data corpora giving open access to them as tei xml files it will process them into an online database which will contain a synoptical digital edition of all sources reaching out to both researchers and the broader publicafter the projects lifetime the database can be continuously enriched with sources from early modern times as the projects methodology especially focuses on reproducibility and interoperability with other projects this will contribute to broaden our perception of islam and of christianmuslim relations docobyzs multidisciplinary approach will enable scholars to tackle urgent questions of hitherto unstudied intellectual interactions between the latin and byzantine antiislamic tradition and quranic knowledge in medieval christianity
security research ncps network 5

the main aim of seren5 is to improve and professionalise the skills of the cluster 3 cl3 national contact points ncps acrosseurope simplifying applicants access to horizon europe he calls and raising the average quality of submitted proposalsstarting from the assumption that the ncp role is crucial in order to raise the participation in he in terms of both quality and quantityseren5 overall concept is that the cl3 ncp community requires knowledge skills competences and a proven comprehensivesuite of tools to convey a message in a multicultural and multidisciplinary environment such the one that characterises cluster 3 and to effectively support its broad based constituency therefore the project is based on three pillars i ncps capacity building and competence development ii development of targeted and high quality services events and tools for cl3 applicants and stakeholders iii cl3 community building and general mainstreaming of cl3 ncps in horizon europe
role of extracellular polymeric substances eps in the prevalence and resilience of lotmaria passim

lotmaria passim is a trypanosomatid parasite of bees highly prevalent in honeybee colonies considered a major factor in colony loss yet the molecular mechanisms it uses to survive both inside and outside its host are unknown preliminary studies showed that lpassim secretes extracellular polymeric substances eps and differentiates into surface attached colonies mimicking the mechanism of bacterial biofilm formation eps provides environmental resistance to changing and extreme physicochemical conditions eg in bacteria thus i hypothesise that eps confers resistance to lpassim and have an active role in the bee gut in roleps i aim to explore the role of eps secretion and the mechanisms of biofilm formation in the prevalence and resilience of lpassim chasing three objectives i study the response of lpassim biofilms to biotic and abiotic stressors ii identify the genes involved in eps secretion and the developmental differentiation into biofilms using crisprcas9 and iii explore the function of eps in honey bee health roleps will be developed at the university of granada spain within the biochemistry and molecular parasitology group lead by prof de pablos who has developed a protocol to isolate trypanosomatid strains from field isolates optimized the isolation of the secretome of trypanosomatids and settled all the facilities for genetic engineering assays a secondment is planned at the centro de investigacin apcola y agroambiental ciapa in marchamalo spain supervised by dr higes expert on bee health roleps is an innovative project as it will analyse for the first time the role of eps and biofilms in a trypanosomatid parasite of bees it will integrate genetic engineering in the field of bee parasitology and test parasitesecreting substances as protection against contaminants in bees roleps is fully achievable due to the easy handling of the model organisms thus i expect roleps has important repercussions in bee health
monitoring crustal stress state from 4d seismic imaging

tectonically active crustal settings such as volcanic fields and seismogenic fault systems are characterized by evolving stress critical conditions that can be detected by continuously measuring isotropic and more importantly anisotropic elastic properties this is because these observables are strongly sensitive to the opening of fractures and to the infiltration and migration of magma and crustal fluids which are more prominent before major volcanic eruptions and earthquakes with this respect the team members of the erc stg 758199 newton are currently finalizing a novel 4d seismic imaging technique that allows the automatic detection of relevant changes in the crustal isotropic and anisotropic structural patterns and by inference of the crustal stress state the new seismic inversion strategy has been tested with synthetic and real seismic datasets from the etna volcanic field with results indicating that it can detect robust changes in seismic anisotropy related to variations in the crustal stress state preceding volcanic eruptions and local earthquakesgiven the current limited capacity to determine the evolving plumbing system dynamics which in turn hampers the forecasting of major paroxysmal events the activities of modem will focus on the development and distribution to volcano observatories of an opensource software which will include the novel methodology for monitoring the crustal structure and stress state evolution in volcanic fields the software will be firstly validated and integrated with the monitoring apparatus of the etna volcano and subsequently disseminated over other european and international volcano observatories as the monitoring system can be applied to any crustal setting our future goal is to commercialize the software providing a service to oil and geothermal companies interested in characterizing timedependent fracturing patterns and fluidbrineoil distribution in economically sensitive fields
sensing using quantum oct with ai

oct is a key imaging technology allowing noncontact high resolution 3d imaging which has helped to save the sight of millions of people however progress has stalled since reaching the axial resolution dz limit of 1 um quantum oct qoct offers a step change x2 improvement in dz and greatly reduces dispersion in addition control of orbital angular momentum oam reduces noise and improves edge and surface profile definition and discrimination of chiral objects sequoia will deliver the highest resolution oct system ever built protected from noise by artificial intelligence ai based oam control in a realworld application retinal imagingunderpinning sequoia is an ultrastable ultralow noise comb source of unprecedented bandwidth 250400 nm which builds on nkts worldleading supercontinuum sources and adds new ptb techniques for stabilisation and noise controlaibased algorithms upv will be used at tud to program spatial light modulators to encode high purity highdimensional oam onto the qoct beams to increase resilience to noise and improve imaging qualitympd will deliver new singlephoton avalanche diode arrays specifically tailored for quantum imaging to perform photon coincidence correlation at an unprecedented ratenors worldleading classical oct software will be extended to create the first ever qoct softwaretheoretical work at ncu will develop the first mathematical models of noise in qoct to optimise the spontaneous parametric downconversionptb will perform metrological characterisation of all relevant parameters and dtu will quantify the qoct advantage over classical octretinal imaging using stable test standards from wwu will be performed with automated aialgorithms upv to compare performance with classical octard will perform a detailed technoeconomic and social life cycle analyses to evaluate future markets and impacts viv will coordinate an extensive dissemination programme with a highprofile advisory board
direct coprocessing of co2 and water to sustainable multicarbon energy products in novel photocatalytic reactor

solar fuels produced via solar driven co2 and water conversion can contribute to drastically reducing ghg emissions and implement a manmade carboncycle complementing the naturalone deploying the circular economy strategy however at present significant improvement in the photocatalysts and reactor technology is required for solar fuels production to become technically feasible scalable affordable secure sustainable and efficient desired is a highrisk highreturn project focused on establishing the technological feasibility and sustainability of a novel fuel production system the desired system for direct coprocessing of possibly atmospheric co2 and water to produce multicarbon c2 energyrich products using sunlight as primary energy source the desired system will produce c2 solar fuels without overlooking c1 species such as methanol or methane by direct coprocessing of co2 and water using novel and recyclable hybrid photoelectrocatalysts supported on frustules or zeolites in an innovative photoreactor design applying for the first time oscillatory flow principles combined with direct light irradiation with regards to applications desired will focus on products which by 2050 would be used per se or as intermediates to produce dropin fuels for sectors where direct shift to batteries or h2 is not a technically and costefficient option eg aviation knowledge of the economic affordability environmental benefits and social acceptability of this approach will be investigated desired promotes an interdisciplinary approach to research and innovation undertaken by a consortium of 7 european partners and complemented by crosscutting activities including modelling process simulation sustainability and technoeconomic assessment as well as impactful dissemination communication capacitybuilding and exploitation activities that support the exchange of knowledge across and beyond the consortium and project