Dragon09/odtu_chatbot huggingface dataset:
holistic approach for tackling food systems risks in a changing global environment

the overall objective of holifood is to improve the integrated food safety risk analysis ra framework in europe to i meet future challenges arising from green deal policy driven transitions in particular in relation to climate driven changes ii contribute to the uns sustainable development goals and iii support the realization of a truly secure and sustainable food production holifood will apply a system approach which take the whole environment into account in which food is being produced including economic environmental and social aspects three supply chains will be considered ie cereals maize legumes lentils and poultry chicken artificial intelligence ai and big data technologies will be used in the development of early warning and emerging risks prediction systems for known and unknown food safety hazards in addition tools methods and approaches will be developed for hazard detection and will be targeted and nontargeted and new holistic risk assessment methods will be develop in which food safety risk will be embedded in a comprehensive costbenefit analysis of the food system including positive and negative health environment and economic dimensions an effective impact pathway will be developed and implemented through integration of the holifood outputs into the legal framework associated with the food risk analysis process the impact pathway will be supported by an electronic data and knowledge sharing platform aiming at the full digitalization of food safety systems and supporting transparency and impact for all stakeholders in order to align with stakeholder priorities preferences and user requirements the holifood innovations will be designed and tested in a multi actor approach ie living lab involving all stakeholders eg authorities food producers and citizens
tracking the spread of avian influenza viruses in live bird market networks

avian influenza viruses aiv represent tenacious and major public and animal health problems across the world controlling aiv at its poultry source in asia is essential to decrease the virus load in susceptible avian species and environment limit the risk of human infection with aiv and minimize the risk for future global aiv pandemics in trackflu i will improve our capacity to quantify model and predict the aiv spread in live bird market lbm networks in asia which are urgently needed if the impact of future epidemics of aiv is to be mitigated and thus represent key elements for pandemic preparedness for the first time extensive field work will be combined with stateoftheart network analysis phylodynamic and disease modelling tools with the view to successfully influence policymaking i will use this unique and innovative analytical pipeline to address the following key objectives o1 identify the factors shaping the connectivity of lbm networks o2 quantify the transmission dynamics of aiv in lbm networks and o3 optimize strategies to limit aiv spread in lbm networks trackflu will help us to disentangle the lbm networks connectivity and to resolve the aiv transmission dynamics in lbm networks trackflu will result in a cuttingedge predictive model of aiv spread that incorporates for the first time most of the biological complexities of aiv spread in lbm networks in asia the model and its associated webapplication will represent very powerful and innovative tools for the design of novel control strategies tailored to the key features of aiv transmission in lbm networks trackflu will thus contribute to the active research issue of improving capacity to predict aiv transmission in these complex systems in asia hence addressing the unmet need of local stakeholders and decision makers for better predictive tools with trackflu i anticipate very promising results with huge impacts on animal and public health
antibacterial wound dressing based on advanced nanotechnology to improve the efficiency of wound care

infected wounds are a major cause of limb amputations among patients with chronic diseases like diabetes 10mln amputations occur annually causing 100bln additional healthcare costs during covid19 pandemic the number of amputations rose 10 fold due to low efficacy of current solutionsnanordica develops an advanced antibacterial wound dressing awd to prevent and treat wound infections we have demonstrated that our awd removes bacterial infection 8x better than current best our value propositions are high efficacy and low costglobal antibacterial wound dressing market is projected to reach 42bln in 2026 at cagr 57 our business model is b2b using distributors to reach our customers ie hospitals we have a priority for intellectual property and initiated a pilot clinical trial at the largest estonian hospitalour mission is to bring awd to the market to improve the outcome of wound infections lower healthcare costs and help hundreds of millions of patients
predictive tool of seagrass health to optimize the design of low crested structures in the mediterranean sea

coastal erosion is one of the major global threats to people the economy cultural assets and ecosystems in many regions of the world and also in europe valuable coastal ecosystems such as seagrass meadows are particularly threatened by these erosion problems and effective protection measures for their conservation are urgently needed lowcrested structures lcs are the typical coastal defence in europe with a design mainly based on their hydrodynamic and morphodynamic behaviour and little attention is usually paid to the ecological consequences of their construction the construction of breakwaters can affect seagrasses by altering the circulation and sediment transport to the adjacent habitat but fragmented and scientificbased criteria are difficult to manage in present engineering design and therefore ecological impacts are often not taken into account within this research project the creation of a new quantitative prediction tool will be investigated to allow civil engineers and decisionmakers to optimize the design of breakwaters and reduce the uncertainty related to their environmental performance contributing to the preservation and conservation of seagrasses during the lifetime of breakwaters in particular the project will focus on the mediterranean sea to ensure the persistence of two characteristics seagrass species cymodocea nodosa and the most important endemic and slowrecovery posidonia oceanica the fellowship will be carried out at the universitat politcnica de valencia upv in spain under the supervision of professor josep r medina international expert in maritime and coastal engineering in collaboration with dr nuria marb internationally renowned researcher on marine and seagrass ecology at the instituto mediterrneo de estudios avanzados imedea a placement is planned at the engineering consultancy ingeomar to put into practice and refine the predictive model boosting its integration in coastal protection proyects
retrofitting towards climate neutrality

the main objective of green marine is to significantly accelerate climate neutrality of water borne transport through retrofitting existing fleets with cost and emission control solutions to support decision makers retrofitting protocols and a software tool catalogue that gathers knowledge will be developed and validated we will demonstrate these tools and the innovative solutions aimed at carbon capture mineralization which also aids in deacidifying our seas energy savings for hvac systems through airreuse carbon and water capture with membranes and the use of excess engine heat to produce a syngas to save on fuel consumption an ultrasound technology will be tailored to suit vessels allowing airreuse saving energy for hvac systems and operated as pretreatment enhancing a membrane carbon capture process the camg alkali solvent capture process is capable of removing 75 of the co2 from flue gases all solutions will be demonstrated first on a landbased engine followed by the selection of the most suitable solution for a demonstration on a waterborne vessel the landbased demonstrations will represent the operation of a majority of vessel engines by developing retrofitting protocols simulations of the solutions data generated at the demonstrations a software catalogue tool will be developed through engagement activities this tool will gain more users and more knowledge its value and effectiveness will increase for all users the project aims to bring the different solutions to trl 8 the demonstrations the software tool catalogue and the dissemination and exploitation activities ensure that project results will be replicated globally the consortium consists of 10 partners from 7 countries with 4 research institute 1 ship company which will host a demo as end user and 5 smes
temporal processing in drosophila melanogaster

all information processing in nervous systems relies on spatial and temporal patterns of neural activity while spatial patterns are dictated by neuroanatomy the mechanisms that give rise to temporal activity patterns are diverse they range from fast voltage dynamics of single neurons at one end of the spectrum to slow transcriptional and structural changes at the other but the rules that shape signals at timescales in between milliseconds and minutes are poorly understood the proposed research aims to uncover mechanisms of temporal information processing at these intermediate timescales at which temporal patterns are thought to emerge from recurrently connected circuits detailed insight into the function of these circuits has been limited by the large number of circuit elements by the lack of knowledge about their connectivity and by the impracticability of recording from all circuit elements under naturalistic conditions in drosophila melanogaster these limitations no longer apply the comparatively low number of neurons their wellmapped connectivity and our ability to record and control their activities make mechanistic concepts testable we will focus on three processes in the brain of drosophila that unfold over three timescales ranging from milliseconds to minutes 1 temporal filtering in the motion vision system 2 sequential sampling of motion information in the leadup to a perceptual judgement and 3 temporal integration of distance during locomotion patch clamp experiments in the smallest of invertebrate neurons in vivo will allow us to record activity at the highest temporal resolution we will combine this technique with behavioural genetic and imaging experiments to test the roles of individual neurons their biophysical properties and their synaptic connections in processing signals at intermediate timescales the proposed experiments will further our understanding of motion vision perceptual decisionmaking and path integration
mapping social disruptive effects of extractivism

erradicating poverty reducing inequality and achieving decent work and economic growth for the least developed countries is a major challenge in the 21st century in this context the way we provide and manage natural resources necessary for our daytoday athmosphere water minerals wind vegetation sunlight land plays a fundamental role as the resources tend to be extracted through largescale infrastructures and in middle and low income countries since 1970 extraction of fossil fuels coal oil and gas has increased from 6bn tonnes to 15bn tonnes metals have risen by 27 a year and other minerals particularly sand and gravel for concrete have surged nearly fivefold from 9bn to 44bn tonnes overall resources are being extracted from the planet three times faster than in 1970 even though the population has only doubled in that time un global resources outlook 2019 this study aims to build evidence based theories around and for the better understanding of the socalled resource curse ie the paradox that countries with an abundance of natural resources tend to be associated with lower growth rates promotion of authoritarianism and worsening living standard we will give a central place to the concept of social disruption a term used in sociology to describe the alteration dysfunction or breakdown of social life often in a community setting by bringing together earth observtion eo and secondary data analysis to the study of natural resources extracition in colombia we will provide evidences that the largescale extraction of resources disrupt regional economies in a number of ways increase in crime poverty and inequality and the creation of an economic dessert in the surrounding of the extraction sites the results are expected to challenge some of the existing regional development theories whille highlighting the conditions under which extractivism can still drive sustainable development
learning from bats new strategies to extend healthspan and improve disease resistance

the medical financial and emotional costs imposed by ageing and infectious diseases are major challenges for our societies strikingly while past research has not provided solutions for extending human healthspan and preventing the harmful consequences of infections nature has solved both problems in the only flying mammals the bats among mammals bats exhibit an exceptional longevity with little signs of agerelated diseases despite being reservoirs for numerous deadly viruses viral infections in bats are mostly asymptomatic due to unique immune system adaptations the overarching goal of batprotect is to achieve breakthroughs in our understanding of the molecular basis of bats extended healthspan and disease resistance to ultimately discover new directions to improve human healthspan and disease outcome batprotect integrates a team of worldleading experts in bat biology genomics immunology and gerontology to synergistically i elucidate the molecular mechanisms that bats use to slow down expected ageing ii identify the driving molecular mechanisms behind bats viral tolerance and limited agerelated inflammation iii uncover the genomic basis and evolution of extended healthspan and disease tolerance in bats and iv develop transgenic animal models to functionally validate the uncovered bat adaptations we will generate 150 reference quality bat genomes the novel immunological bioinformatic cellular and molecular tools required to take an integrative multiomics approach and uncover the age and immune changes that occur in wild and captive bats across the ageing spectrum we will identify the top regulators of longevity and immunity using deep neural networks analyses to functionally validate in our cellular systems and novel transgenic animal models batworms and batmice ultimately we will provide a deeper understanding of extended healthspan and disease resistance and will pave the way for future therapeutics
the malaria chemical atlas revealing the parasitehost functional interactome

malaria is the most lifethreatening parasitic disease in humans invasion of the malaria parasite plasmodium falciparum pf into the blood circulation rewires the harmonious networking between the resident cells until recently pf was not thought to be able to communicate when nested within infected human red blood cells rbcs however we and others have laid the foundations of pf communication via extracellular vesicles we now hypothesize that in order to survive in the hostile host environment pf secretes chemical inducers eg metabolites peptides to actively coordinate life decisions as a group and to control the surrounding host cells remarkably we obtained proofofprinciple preliminary results in the form of an isolated active chemical fraction that inhibits pf population growth in a densitydependent mannerour overarching goal in malchematlas is to expose this yettoberevealed mode of communication in malaria celltocell chemical signaling we will combine analytic chemical biophysical and omics technologies with machinelearning approaches to comprehensively reveal and characterize the functional chemicals that i facilitate parasite density growth and sexual development parasiteparasite signaling ii dictate parasite crosstalk with circulating host immune cells and nave rbcs parasitehost communication and iii affect downstream signaling cascades between the hosts innate and adaptive immunity hosthost communication in this effort we will leverage our extensive hplcbased analytical fractionation pipeline combined with nmr and metabolomics analyses for identifying malariasecreted autoinducersour preliminary findings demonstrate the potential of our basic research to be applied to the translational level of intervention identifying natural chemical killers offers a previously unexplored direct strategy to fight malaria the highest gain we can ask for when researching this deadly disease
shifting to zeroemission logistics with rightsized missionfocused n1 elcvs

current market dynamics in eu reveal a gap between supply existing n1 vehicles and demand evolving needs of urban logistics and climate targets in 2023 12m new lcv registrations were dieselpowered and only 108200 batteryelectric lastmile logistics the least efficient and most complex part of the supply chain presents significant opportunities for improvements at vehicle and operations levels dynamic requirements and increasing environmental impact require innovative solutions from the automotive industry both from high volume oems and new entrants s2z aims to capitalize on the benefits of both vehicle platforms in the n1 segment represented by ivecos edaily multipurpose platform and alkes atx designforpurpose platform ultimately contributing to shifting to zeroemission logistics through rightsized missionfocused n1 elcvs to achieve this vision s2z proposes a 4step user and missioncentric design approach placing endusers and their needs at the core of all project activities to this end s2z involves 5 lsps mobility operators as partners gruber dhl diakinisis clem inpost as a result we will codevelop and shape at least 6 novel n1 concepts with enhanced and safe functionalities leading to tighter market fit particularly in the segments of ecommerce returns and cold deliveries innovative concepts from modular cargo bodies to vehicle control strategies with optimized tyres brakes as well as dual transport of people freight will be physically prototyped and tested in reallife operations in 6 pilot sites be gr it 2 x no pls2z brings a multidisciplinar consortium of 30 partners from 10 countries to cover the complete automotive and logistics value chains complemented by policymakers to effectively ensure our route to market overcoming barriers for the adoption of s2z elcvs reducing operational costs and environmental impact in scalable urban suburban operations
advancing quantum computers for and with quantum thermodynamics

while thermodynamics is one of the most wellestablished physical theories there is much that remains to be worked out in its extension to the quantum realm with the miniaturization of electronics down to the nanoscale along with the emergence of quantum technologies it is becoming essential to gain a better understanding of thermodynamics at the quantum level the emergence of quantum computers qcs in the last decade provides a gamechanging new tool for research into quantum thermodynamics qt furthermore still in nascent stages qcs stand to gain vast improvements in performance from new insights derived from qt an elegant synergy therefore exists whereby i qcs can be used to improve the fundamental understanding of qt and ii principles from qt may be used to improve the reliability of qcs inspired by this synergy this proposal includes two thrusts to advance progress along these two fronts for the first thrust i aim to develop new algorithms packaged into welldocumented opensource software for simulating thermal properties and behaviors of quantum systems on qcs this work will culminate in attempting the firstever experimental validation fluctuation relations theoretical pillars of qt for open quantum systems on a qc for the second thrust i aim to use the principles of qt to implement an algorithmic cooling scheme that can improve the overall performance of qubits for any desired application on a qc this work will culminate in attempting the firstever experimental demonstration of algorithmic cooling on a qc the proposed research requires an interdisciplinary approach encompassing quantum information and computation thermodynamics and statistical mechanics and computational science cs the complementary expertise and experience of the experienced researcher in qc and cs and the supervising host in qt will foster a productive twoway transfer of knowledge and facilitate the success of the research goals
highly integrated versatile laser source enabling twophoton excitation in digital diagnostics and biomedical research

the overall objective of hilight is to implement innovative solutions into versatile light sources and systems as tools for biomedical and healthcare applications centred around twophoton excitation fluorescence lifetime measurements and imaging microscopy we propose two specific use cases i instantaneous digital histopathology and ii biomedical research in the context of cancer research and diagnostics hilight proposes a miniaturised and versatile optical pulse burst source together with innovative sensing technology that will permit us to overcome those limitations in soa instrumentation that often confine the use of twophoton microscopy and timeresolved detection to the specialist laboratory we envisage that the hilight innovations could disrupt activities in various fields and a range of market segments including academic and research institutions biotechnology and medical facilities these include applications targeted to improve our understanding of the molecular mechanisms of disease using in vivo ex vivo or 3d organotypic cultures with the ultimate aim of developing better tools for fast and early diagnosis and more effective therapeutic interventions hilight is structured around nine work packages covering the whole value chain coherently with the concept of the project standing on strong enabling technology foundations and targeting biophotonic and medical application domains hilight consortium is made up of five leading partners from various fields experienced in european collaborative projects and from five different european countries fr de it ch and uk hilight is built on several prior and ongoing successful collaborations between partners which provides a strong guarantee for successful interaction within the consortium and a smooth implementation of the workplan
ispeak a natural language processing study in youth with subclinical psychotic experiences

up to one fifth of young people report that they have experienced unusual perceptual experiences thoughts or beliefs these experiences which we call psychotic experiences or pe can take the form of hearing voices or seeing visions or feeling paranoid or believing things that are not true as part of my erc consolidator award ihear i and my team have learned a great deal more about these experiences and what they mean for young people we know that these experiences can be transitory in most cases but that in some young people they recur throughout adolescence and adulthood we know that for some young people these experiences can be associated with poor functioning and poorer mental health but for others they are not pathological we have identified the need for an instrument that can differentiate between pathological and nonpathological psychotic experiences this will support early risk screening and development of interventions among those who experience pe we propose to search for natural language patterns within selfreported pe that are associated with high and low levels of mental illhealth our hypothesis is that young peoples first person account of their experiences are likely to contain natural language phrases that could be used to differentiate between pes that occur in the context of mental illhealth are likely to require intervention and those that do not knowledge of natural language patterns for pe would be a valuable step in improving assessment tools in clinical practice additionally this could be a valuable new resource for digital tools and ehealth which is a growing area for mental health