Dragon09/odtu_chatbot huggingface dataset:
new biobased and sustainable raw materials enabling circular value chains of high performance lightweight biocomposites

new lightweight highperformance composite hpc materials and efficient sustainable processing technologies will have an enormous environmental and performance benefit in all sectors of application however current sustainable hpc application is limited to large sectors due to their limitations in terms of long processing times high prices and low recyclability to overcome these limitations rlightbiocom propose a paradigm shift in the way hpc are manufactured and recycled unlocking sustainablebydesign production of lightweight hpc therefore the project will enable new circular value chains towards rlightbiocom results contributing to environmentalrelated eu goals and reducing the hpc waste generation and the use of nonsustainable fossil resourcesto this end a sustainable catalogue of new advanced biobased and recycled hpc materials will be initially developed with inherent recyclability properties at least 3 new types of bioresins 4 new biomassderived nanofillers and additives and 3 families of sustainable fibrebased textile products to reduce current associated manufacturing costs and high energy consumptions and emissions efficient processing techniques will be developed 2 new fast curing techniques combined with recycling technologies for the new catalogue of materials to reduce waste generation and induce circularity a new open method and related tools coupled ecological optimisation framework will promote and standardise holistic sustainable hpc design modelling and systematic optimisation leading to continuous sustainable catalogue growth and inclusion of new families of biobased recyclable lightweight hpc at competitive cost all results will be validated in 3 use cases at automotive infrastructure and aeronautic industries with specific business cases contributing to establishing new resilient sustainable and innovative value chains in the eu hpc industry promoting a change of paradigm from linear to circular ones
moving cellbased immunotherapies to fight bacterial lung infections into the clinics

harnessing the immune system to combat global diseases has introduced a new era in modern medicine the imaclung proposal will extend this concept and will pave the way for the first immune cellbased therapy to combat bacterial airway infections with more than 2 million deaths around the world in 2020 lower respiratory tract infections are still the deadliest communicable disease with unmet medical need highlighting the necessity for radical new approaches to develop therapeutic avenues the imaclung proposal aims at the adoptive transfer of human macrophages directly into the infected lung and to restore the endogenous alveolar macrophage am cell pool to efficiently resolve bacterial airway infections and to mediate lung regeneration at the same time imaclung will harness the unique features of induced pluripotent stem cells ipsc to use macrophages imonomac as a cellbased immunotherapy following the adoptive transfer of these cells directly to the side of pulmonary infection imaclung is built upon the pioneering work of the ercstg ipsc2therapy in which the antibacterial activity of imonomac against a variety of pulmonary mycobacterial infections has been successfully demonstrated in vivo in addition ipsc2therapy has also successful shown the first scalable production of offtheshelf imonomac using industry compatible bioreactors which now paves the way for the development of seminal nontherapeutic concepts to enable clinical transfer imaclung will build a team of medical scientific and industrial experts all dedicated to bring imonomac into humans to enter the next stage of the clinical translation pipeline a path towards the clinics will be developed which will facilitate subsequent exploitation and transfer into patients imaclung will bridge the seminal therapeutic concept from bench to bedside having broad value for patients society medical personal and the healthcarebiopharmaceutical industry within europe and beyond
quantifying fault response to enhanced climatedriven erosion using cosmogenic nuclides and geomechanical models

mountain topography embeds a signal of past climatedriven erosion and tectonic evolution numerical models are powerful tools to characterize this delicate interplay and outputs can be used as a framework to understand the current climate or forecast future fault behavior and earthquakes to validate models of climate and tectonic interactions during mountain building requires highresolution records of erosion rates sedimentation rates climate variability and fault activity however sites with detailed quaternary records of all these variables are rare which hinders our ability to validate model outputs a multisystem approach using field data to calibrate models is required to enhance the predictive power of models and their capacity to tackle major unresolved tectonic and climatic problems like how climateenhanced erosion affects rates of faulting this project will 1 develop cuttingedge datadriven geomechanical models that integrate tectonics climate and erosion during mountain building 2 collect new field data 10be boulder ages and highresolution topographic data to generate a highresolution record of quaternary fault activity in the andean foreland and supplement this data with existing erosion rates rock exhumation rates and sedimentation records and 3 calibrate and apply the models using the field data to quantify the extent that climatedriven erosion affects rates of tectonic processes this project will push the boundaries of our understanding of how tectonic and climatic variables influence landscape evolution whilst developing datadriven geomechanical modelling techniques with powerful applications to widespread tectonic climatic and sedimentological processes the project will also give the researcher experience in a pioneering modelling field whilst fostering intraeuropean and global collaborations and helping the researcher achieve their career goal of becoming an independent academic in europe
human centric indoor climate for healthcare facilities

over 4 million hospital patients acquire a healthcareassociated infection hai in the eu each year moreover the global crisis of antimicrobial resistance means that hai is posing an increasing cost and risk of mortality there is clear evidence that airflow controls the dispersion and exposure to airborne pathogens and determines the contamination of critical surfaces in the humancentric climate hcc which is defined as the microenvironment which surrounds and is close to a human body this points to a significant need for innovation in healthcare indoor environments to tackle the challenge of infectioncontrol while improving thermal comfort and energy efficiency in hospitals to achieve this we must both advance the fundamental understanding of how people are exposed to airborne pathogens and develop new tools and techniques to enable effective design and operation of healthcare environments specifically there is a need to understand better the local influence of airflows on particles in hcc quantify the transient behaviour of airflows and contaminants due to healthcare activities like surgery develop methods for optimising and adapting ventilation systems to control for risks in different environments like operation rooms and isolation rooms and develop tools to enable realtime interaction with environments during design and operational phases bringing together 8 leading academic teams 4 healthcare facilities and 8 hvac industry partners the humanic network aims to build a new approach to hospital environmental design through the concept of hcc and the training of 15 early career stage researchers to address these needs humanic will create and disseminate fundamental and applied science to improve the knowledge base and innovate new technologies for designing and operating hospital ventilation and thermal systems and for reducing infection risk by at least 30 meanwhile satisfying requirements of thermal comfort safety and energy
boosting the market deployment of safe effective and sustainable innovations for soil improvement from biowaste towards regenerative soil systems

bin2bean will support cities in their transition towards regenerative soil systems by promoting innovations for soil improvement from biowaste with a valuebased approach the project will implement 3 living labs as pilot cityregions to follow a multiactor and participative approach in each ll after mapping local contexts in terms of material and monetary flows a tailored evaluation framework to demonstrate the safety environmental and socioeconomic performance of soil improvers will be codesigned and implemented through field testing on experimental sites feasibility studies and choice experiments the data obtained will feed into a pilot scoring system that will be codeveloped and validated during the project to help cities selecting the most effective solutions adapted to the geospatial context ie inner city urbanrural fringe and the wider market the highest scored solutions will be selected for the development of innovative and tailored business models the latter will match to stakeholders willingnesstoadopt circular implementation packages eg collection schemes cooperation networks infrastructures and fee structures the premarket processes will be monitored through technoeconomic assessment tea finally based on all previous results local national and eu policy roadmaps will be drafted including waste charging policies and citizen awareness campaigns in the cityregion that will be piloted in lls all this will feed into a pdca plan do check act approach enabling cities to create a continuous valuebased improvement loop towards regenerative soil systemsbin2bean will support local waste management with the creation of 40 startups specialising in the soil improvers value chains this will help to reach europes 2035 objectives of reducing landfill to 10 of total waste while reinjecting nearly 135000 tonnes of nitrogen and 45000 tonnes of phosphorus into soils in an environmental human and sustainable way
cartan and differential geometry lie theory quantum groups and non commutative geometry for novel and innovative applications to quantum algorithms and geometric deep learning

lie theory pervades all areas of mathematics by providing natural encodings of symmetries representation theory and cartan geometry are two of its most successfull manifestationscalifornia aims to push the frontier of research in these two key topics lie theory and cartan geometry in synergy with the complementary investigations in the areas of quantum groups and more generally non commutative geometry including physical applications california goal is to apply the new mathematics originating by the above research to the new and strategic fields of quantum computing and geometric deep learning top priorities in horizoneurope
cellular models for tissue function in development and ageing

one of the most fundamental challenges in contemporary biology is in fact also one of the most classical ones how to comprehend macroscopic tissue function from the activities of its microscopic cellular components the remarkable advent of single cell genomics over the last decade is realizing this challenge at unprecedented scales measurements of the molecular states of thousands or even millions of cells can now be acquired efficiently and tools for describing cellular states phenomenologically became well established but how to model ensemble of cells in tissues is paradoxically even more difficult than before given this new unprecedented experimental resolution to this end we will develop a new computational and theoretical framework for understanding ensembles of single cells as they interact and dynamically differentiate proliferate or degrade parametric and mechanistic models for defining microscopic cell states over a mathematical manifold will be developed and the dynamics of ensembles of cells over time and in space will be inferred from new experimental approaches capturing whole tissues over time or within spatially registered domains importantly our models will describe tissues dynamics as change in specific gene regulatory epigenomic and signaling programs and we will develop high throughput experiments to combinatorically perturb embryonic and hematopoietic systems in order to test such models extensively our research will thereby extend single cellcentric models toward describing dynamics in tissues with experiments and data collection aiming at rapid translation of the models to actionable and testable strategies for manipulating systems of interest this will be applied to transparent and epigenetically precise cell type engineering to discoveries using a unique resource on human hematopoietic ageing and to deep tissue level analysis of combination immunotherapy
beat bcell lymphoma biomarkers of effective cart19 assessed in the tissue microenvironment

project title beat bcell lymphoma biomarkers of effective cart19 assessed in tissue microenvironmentbcell lymphomas encompassing follicular lymphoma fl and large bcell lymphoma lbcl pose significant health concerns while the use of tcells modified with a chimeric antigen receptor targeting cd19 cart19 offers a potential breakthrough in treating these malignancies it is imperative to unravel the intricate dynamics between the cart19 and the tumor bcells within their unique tissue microenvironment tmethe beat bcell lymphoma initiative is poised to transform lymphoma therapeutic strategies more than just advancing the status quo this project is geared towards unveiling novel biomarkers that facilitate immediate feedback on therapeutic outcomes these newfound markers will empower clinicians and patients with predictive tools for cart19 interventions and serve as cornerstones for redefining inclusion criteria in subsequent clinical trials but the ambition of this endeavor goes beyond mere biomarker discovery it promises indepth revelations on how cart19 impacts actual patientderived tissues deepening our knowledge and inspiring fresh treatment avenues the short term concrete vision finetuning cart19s performance and honing the initial patient selection processas a medical doctor with a specialization in hematopathology ive offered numerous diagnoses of bcell lymphomas grounded in histological and molecular markers predominantly sourced from tumor bcells my foundational training as an immunologist has sharpened my curiosity drawing my attention to the often underemphasized tissue microenvironment my affinity for bioinformatics further equips me to navigate and interpret vast datasets efficiently to ensure the success of this project and to further my journey towards becoming an independent researcher i partnered with the renowned alizadeh lab at stanford usa and will later join the de miranda lab in the netherlands
universality phenomena in geometry and dynamics of moduli spaces

geometry and dynamics in the moduli spaces proved to be extremely efficient in the study of surface foliations billiards in polygons and in mathematical models of statistical and solid state physics like ehrenfest billiards or novikovs problem on electron transport ideas of study of surface dynamics through geometry of moduli spaces originate in works of thurston masur and veech the area is flourishing ever since contributions of avila eskin mcmullen mirzakhani kontsevich okounkov yoccoz to mention only fields medal and breakthrough prize winners made geometry and dynamics in the moduli spaces one of the most active areas of modern mathematics moduli spaces of riemann surfaces and related moduli spaces of abelian differentials are parametrized by a genus g of the surface considering all associated hyperbolic respectively flat metrics at once one observes more and more sophisticated diversity of geometric properties when genus grows however most of metrics on the contrary progressively share certain similarity here the notion of most of has explicit quantitative meaning for example in terms of the weilpetersson measure global characteristics of the moduli spaces like weilpetersson and masurveech volumes siegelveech constants intersection numbers of classes were traditionally studied through algebrageometric tools where all formulae are exact but difficult to manipulate in large genus most of these quantities admit simple uniform large genus approximate asymptotic formulae the project aims to study large genus asymptotic geometry and dynamics of moduli spaces and of related objects from probabilistic and asymptotic perspectives this will provide important applications to enumerative geometry combinatorics and dynamics including count of meanders in all genera solution of arnolds problem on statistics of random interval exchange permutations asymptotics of lyapunov exponents and of diffusion rates of ehrenfest billiards
aural culture decoding the sacred soundscapes of medieval europe

medieval monasteries shaped sacred landscapes of europe not only visually but also aurally with the sound of large percussion instruments such as bells matracas and semantron despite they created an authentic aural culture of medieval europe the monastic soundscapes remain unexplored the cultaural project is interdisciplinary aiming to explore a novel area of research the medieval aural culture that infused monastic landscapes and its role in identity creation were the acoustic quality of sacred soundscapes and large percussion instruments relevant for medieval communities what was the spatial imprint of monasteries aural communication did male and female monasteries have similar aural imprints in the soundscape to answer these questions i will receive training on archaeoacoustic methodology at one of the largest historic soundscape research hubs located at the university of barcelona and transversally undertake six case studies in three contrasting regions of europe catalonia norway and serbia including male and female monasteries that significantly retained the medieval setting i will test and document the acoustic properties of soundscapes and large percussion instruments based on the onsite acoustic measurements explore the audibility of the instruments via the acoustic models and examine the role of gender through a comparative analysis i will participate in several research groups for skills and knowledge transfer scientific publications for experts and talks for lecturers and students will efficiently disseminate the projects results at the secondment museum of cultural history university of oslo i will be trained how to communicate research results to the wide public via multisensory exhibitions which will also add significant impact to the fellowship besides at the new medieval exhibition in oslo the results will also be communicated through social networks and public interactive talks in all three countries
unraveling the impact of turbulence in mixedphase clouds

mixedphase cloudsatmospheric complex threephase systems containing suspended ice particles supercooled water droplets and water vaporare responsible for most of the precipitations reaching the earths surface in addition these clouds play a primary role in the planets radiative energy budget and the water cycle despite their relevance there is a lack of a basic understanding of the complex hydrodynamics heat and mass transfer between the different water components with numerous scientific open questions in the last decades many scientific works have shown a significant impact of turbulence in warm icefree clouds and warm rain formation in enhancing condensationevaporation of rain droplets and promoting collisions on the other hand the role of turbulence in mixedphase clouds has never been properly quantified consequently up to now this topic has been nearly exclusively a subject pertaining to atmospheric physics rather than fluid dynamics i want to change this perspective and analyze the rich dynamics of mixedphase clouds using a combination of theoretical and numerical tools developed for general multiphase flows mixclouds is a multidisciplinary project aiming to i understand the impact of turbulence in mixedphase cloud microphysics of water hydrometeors ii quantify this impact by determining typical ice and water droplet size distributions at given temperature humidity and turbulence levels iii developing the next generation of numerical tools to couple multiphase turbulent dynamics at different scales iv developing novel subgrid models to parametrize mixedphase cloud microphysics and test against known atmospheric observations the final results can potentially generate a groundbreaking impact not only in the areas of turbulent multiphase flows and cloud physics but also in climatology and in all environmental and industrial applications involving suspensions of threephase flows in the presence of phase changes
plasmaactivated hydrogel new frontiers solutions in cardiac regenerative medicine

heart diseases represent the main leading cause of mortality in eu and other industrialized countries the development of minimallyinvasive therapies to treat cardiovascular injuries is the subject of intense investigation by the cardiac regenerative medicine community moreover in vitro models of human cardiac pathological tissues mimicking diseasespecific oxidative conditions are demanded for understanding pathological mechanisms at different disease stages and for the development and preclinical validation of novel therapies at reduced costs and in compliance with 3rs reduction refinement replacement principlepacgel aims at the design of novel plasma jetactivated hydrogels based on biocompatible polymers to be exploited as i injectable stimulating systems to promote cardiac tissue regeneration and ii in vitro models of diseased cardiac tissue with tunable oxidative conditions the biological effect will depend on the doses and types of reactive oxygen and nitrogen species encapsulated in the hydrogels modulated by the plasma jet treatment parameters the objectives are 1 to identify the minimal reactive species concentration threshold limit above which oxidative effects prevail by in vitro tests with relevant human cardiac cells 2 to develop plasma jetactivated hydrogels with regenerative potential 3 to design in vitro 3d bioprinted tissue models mimicking different stages of human cardiac diseases my expertise in plasma medicine and chemistry the supervisors consolidated competence in biomaterials design tissue engineering and cardiac regenerative medicine my proofofconcept preliminary results and the availability of all the needed facilities and training opportunities at the host institution will ensure the research progressfurthermore pacgel will address one major societal challenge such as the treatment of agerelated cardiac diseases exploiting green technologies thus achieving still a greater impact on society