Dragon09/odtu_chatbot huggingface dataset:
hybrid electronicphotonic architectures for braininspired computing

as artificial intelligence ai proliferates hardware systems that can perform inference at ultralow latency high precision and low power are crucial and urgently required to deal especially quasilocally ie in the edge with massive and heterogenous data respond in real time and avoid unintended consequences and function in complex and often unpredictable environments conventional digital electronics and the associated computer architecture is unable to meet these stringent requirements with subms latency inference and a sub10w power budget using convolution neural networks cnns on benchmarks such as imagenet classification hybrains vision is to realize a pathway for a radical new technology with ultrafast 1 microsecond and energyefficient 1 watt edge ai inference based on a worldfirst braininspired hybrid architecture of integrated photonics and unconventional electronics the deeply entwined memory and processing like in the mammalian brain obviates the need to shuttle around synaptic weights the most stringent latency bottleneck in cnns is in the initial convolution layers our approach will take advantage of the ultrahigh throughput and low latency of photonic convolutional processors pcps employing novel phasechange materials in these initial layers to radically speed up processing their output is processed using cascaded electronic linear and nonlinear classifier layers based on memristive phasechange memory crossbar arrays and dopant network processing units respectively hybrains sciencetowardstechnology breakthrough brings together the worlds top research groups from academia and industry in complementary technology platforms each of these platforms is already highly promising but by integrating them hybrain will have a transformative effect of overcoming existing barriers of latency and energy consumption and will enable a whole new spectrum of edge ai applications throughout society
the worlds first autonomous blood drawing device

vitestro has created the first fullyautonomous device that draws blood from patients our solution called vd1 performs the whole venipuncture procedure from vein detection to bandage application without any human intervention we have fully developed our technology inhouse and protected it with seven patents more than 1000 volunteers have tried our solution the user acceptance firsttime success rate and hemolysis rate are comparable to those measured using human nurses the vd1 will mitigate the chronic shortage of healthcare personnel it will also standardize the venipuncture process which has been substantially unchanged for decades we target two categories of customers lab chains and hospital labs and we have launching customers in both of them vitestro has a team of nearly 50 people including technical medical regulatory and commercial expertise
extreme neardata processing platform

the main goal is to design an extreme neardata platform to enable consumption mining and processing of distributed and federated data without needing to master the logistics of data access across heterogeneous datalocations and pools we go beyond traditional passive or bulk data ingested from storage systems towards nextgeneration neardata processing platforms both in the cloud and in the edge in our platform extreme data includes both metadata and trustworthy data connectors enabling advanced data management operations like datadiscovery mining and filtering from heterogeneous data sources the three core objectives areo1 provide highperformance neardata processing for extreme data types the first objective is to create anovel intermediary data service xtremedatahub providing serverless data connectors that optimize data management operationspartitioning filtering transformation aggregation and interactive queries search discovery matchingmultiobject queries to efficiently present data to analytics platforms our data connectors facilitate a elastic datadriven processthencompute paradigm which significantly reduces data communication on thedata interconnect ultimately resulting in higher overall data throughputo2 support realtime video streams but also event streams that must be ingested and processed very fast toobject storage the second objective is to seamlessly combine streaming and batch data processing foranalytics to this end we will develop stream data connectors deployed as stream operators offering veryfast stateful computations over lowlatency event and video streamso3 the third objective is to create a data broker service enabling trustworthy data sharing and confidential orchestration of data pipelines across the compute continuum we will provide secure data orchestration transfer processing and access thanks to trusted execution environments tees and federated learning architectures
the silk route across the alps craftsmen migrations commercial exchanges social relations between france italy in the early modern period

my research project aims at reconstructing the dynamics of the migration of silk weavers between italy and france during the early modern age to do so an interdisciplinary approach will be put in place that brings together socioeconomic history migration labor and gender studies history of techniques and material culture combining macrohistorical microhistorical and biographical reconstruction it will be possible to participate in the renewal of studies of migratory phenomena in the early modern period by using digital humanities a database will be created it will collect both demographic data biographical information and visual and material evidence from italian and french museums to answer questions such as what is the balance between attractionrepulsion policies and integrationemargination dynamics who is the migrant artisan and why does he migrate what contribution does migration bring to the country of arrival and the country of departure the investigation of this subject will demonstrate that professional migrations played a key role in the success of the european silk industries in the old regimetraining in italian and international historical research methods and a close dialogue with historians and experts will be crucial for the realization of the project the results achieved will play a crucial role both in terms of academic results and societal impact through the publication of articles in scientific journals participation in conferences and the organisation of lectures and seminars the results of the project will be widely disseminated in addition extensive communication activities are planned social networking meetings with the general public and participation in events organised by the european unionthis project will represent an important starting point for my introduction into the academic field allowing me to expand my skills and my network of knowledge through both european and noneuropean collaborations
evolutionary immunology using insect models to unravel stingdependent conserved and innovative antiviral strategies

as we have seen with the emergence of viral pathogens like ebola zika and sarscov2 our societies are and will continue to be confronted to unknown and perilous viruses to prepare for this we propose to explore the diversity of antiviral genes in animals important signaling nodes have been conserved throughout evolution and regulate expression of antiviral genes that evolve dynamically in response to viral pressure because this occurs in parallel between different lineages each animal has a unique arsenal of antiviral genes with a core of conserved genes but also taxonspecific genes which represent an unexplored resource of potentially unique antiviral mechanisms insects the largest group of animals present high potential for such project but lack of information on the viruses infecting most of them prevented broad investigation up to now our discovery that the cyclic dinucleotide cdn cgamp triggers a strong sting and nfbdependent antiviral protection in drosophila provides for the first time a handle to access the repertoire of induced antiviral genes in insects we will exploit the assets of the drosophila model to address the function of cgaslike receptors and the cdns they produce we will use rna sequencing of cgampstimulated insects and evolutionguided paradigms to identify among the stingregulated genes candidates for functional antiviral screens in insect and human cells hits will be characterized to understand their mode of action as proof of principle we will study the function of nazo a fastevolving stingregulated gene duplicate in drosophila also strongly upregulated by interferons in bats overall this project will provide a unique evolutionary perspective on the sting pathway and will lay the foundations for exploitation of rapidly increasing genomic data to document original antiviral strategies with the longterm goal of inspiring innovative therapeutic approaches against viral infections
sense the new european roadmap to steam education

sense will deliver a flexible roadmap for futuremaking steam education across europe to radically reconfigure the education of young citizens by connecting schools with life and society with work the lack of an appropriate pedagogical methodology linking formal science education with experiences of life and work in informal learning environments is the main reason for the limited uptake of results from prior initiatives to achieve its ambition sense puts forward tests and implements a groundbreaking methodology sensesteam harnessing scientific and artistic inquiry with reflective feedback to promote realworld learning that is culturally relevant and meaningful to pupils in their local communities sensesteam goes at the core of teaching innovation and nurtures institutional and curriculum change multistakeholder engagement supports three progressive levels of maturity of the roadmap awareness action and advocacy at each stage the sensesteam methodology will be implemented as part of incountry steam labs each one focusing on developing materials and actions and evaluating their impact on each of the four key thematic areas of digitization green deal health and work readiness the labs operate as hybrid collectives sharing experiences and deepening impact across eu regions the central outcome of the project will be the production of the new european roadmap to steam education which provides resources and materials produced through incountry and acrosscountries steam labs and via a digital hub the steam academy designed to support steam beneficiaries to cocreate and take forward educational innovation in this way sense shifts the steam landscape towards a new standard of interactional inquiry reforming science education generating a continuum of learning from school to employment and harnessing the potential of future steam professionals to deliver on the ambitions of the new european society
illuminating routes to 3d organoboron molecules

with a steadily growing aging population there is significant strain on the pharmaceutical sector to produce state of the art therapeutics for societal needs whilst respecting the finite resources provided by the environment prominent advances in drug design are reliant on chemical synthesis platforms allowing the efficient exploration of chemical space to discover next generation functional molecules as a result innovation is currently limited by the practical implementation of enabling methods which often becomes the rate limiting factor in cuttingedge research this is more pronounced when translating academic research to industrial settings the current renaissance of organic photochemistry and lightdriven processes in a broader sense provide an opportunity to reconcile the growing demand for new functional molecules with consideration of sustainability and atom economy inspired by the importance of organoboron motifs in medicinal chemistry this eu action lumibor will harness the untapped potential of boron hybridization and boron ligand design to unlock new excited state reactivity paradigms and thereby facilitate the discovery of new methods to access achiral and chiral 3d organoboron scaffolds lumibor will create a structural platform to utilize boron hybridization in the development of next generation lightenabled activation methods understanding the correlation between hybridization and parameters such as excited state energy and adjacent bond dissociation energy will allow access to synthetically versatile highenergy intermediates such as boryl radicals and the triplet excited state strategic control over boron hybridization will also be utilized to regulate reactivity by influencing radical philicty spin density and excited state lifetimes among other parameters collectively lumibor will create expansive guidelines to expand the synthesis arsenal by developing novel platforms to construct desirable 3d organoboron molecules
systemic approaches to improve cardiometabolic and brain health during lifespan

systemic approaches to improve cardiometabolic and brain health during lifespan syslife is an exciting new postdoctoral fellowship programme that seeks to deliver urgentlyneeded breakthroughs in the field of cardiometabolic and brain diseases eg heart attacks strokes depression and diabetes promote scientific renewal in this field and develop its future leaders of tomorrow it is based at the university of turku utu in finland and supported by partners in different sectors utus collegia have a record for excellence in research and for developing their researchers for leadership roles syslife applies their bottomup institute for advanced study model to build on utus outstanding expertise and unique facilities for cardiometabolic and brain health research it will recruit 11 experienced postdoctoral researchers ers in 2023 and 2024 22 in total each for 36 months through an open international competitive meritbased selection process dependent on external peerreview in line with the european charter and code projects that are interdisciplinary intersectoral longitudinal or systemic are encouraged at utu such approaches have resulted in major advances in cardiometabolic and brain health syslife offers scientific excellence fellows will be free to design and pursue novel highquality research projects that seek to improve health outcomes in this area connecting and strengthening research and resources at utu and beyond career development syslife offers mentoring and a new range of options for nontenured researchers to develop as future leaders enabling them to move freely between sectors to acquire unique skills and experiences innovation syslife i enables knowledge and technology to circulate freely at regional national and international levels ii connects intellectual excellence with the practical knowhow and infrastructure needed to realise new concepts iii offers dedicated proofofconcept funds
the geopoliticization of trade policy

currently we witness the geopoliticization of trade namely the linking of national security concerns to trade policy while this geopoliticization is related to the uschina trade war and the russian invasion of ukraine it has become a broad phenomenon affecting most countries worldwide much existing research sees governments in the drivers seat of this process by contrast i explain the domestic politics behind the geopoliticization of trade policy focusing on the interaction between the economic interests of domestic actors and national security concernsmy approach is groundbreaking because i will1 develop an original theoretical argument that distinguishes between three causal pathways for the influence of domestic actors one where the economic interests of domestic actors constrain geopoliticization one where business actors shape trade measures in line with their economic interests and one where business actors drive the geopoliticization of trade2 collect and analyse a large amount of novel empirical evidence including on public opinion and business associations to test this argument this research will cover not only the three most important trading entities china the eu and the us but also india mexico and turkey as examples of middle powers that have only received scant attention3 innovate in terms of methodology by combining evidence on inputs into the policymaking process the policy process policy outputs and policy consequences to test an explanation of politicsthe project promises to have a significant impact not only on the literature on the tradesecurity nexus but also on work done on the political economy of trade interest groups public opinion international conflict and the political economy of emerging countries given that geopoliticization affects the international order the distribution of wealth and the likelihood of interstate conflict the project is of high relevance for several broad debates
airportlevel demonstration of ground refuelling of liquid hydrogen for aviation

alrigh2t responds in full to the expected outcomes and scope of the horizoncl52023d50107 topic by developing and demonstrating two alternative technologies for lh2 aircraft refuelling direct lh2 refuelling encompassing the definition of operational protocols for safe and rapid refuelling the development and testing of a lh2 transfer pump and an instrumented tank their integration in an iron bird laboratory for the execution of refuellingdefueling tests and the delivering of a digital twin model lh2 tanks swap refuelling encompassing endtoend logistic and supply chain of tank modules the design of the associated on and offsite infrastructure and its demonstrationboth concepts will achieve trl 6 by the end of the project undergoing a comprehensive technology evaluation informed by demonstration results in two major airports ie milan malpensa and paris orly or lebourget respectively the two technology lines are complemented by transversal activities for the definition of technical and technoeconomic boundary conditions the demonstration of the use of h2 for ground operations ie h2 powered tow vehicle demonstrated at the malpensa site as well as environmental safety and regulatory crosscutting aspects alrigh2t has the ambition of demonstrating for the first time lh2 refuelling in a scale compatible with airport operations synergizing with the clean aviation research and development efforts at the aircraft level the project is implemented by a consortium built on the competences of top european industrial players positioned along entire hydrogen and aeronautic value chain complemented by research and technology organisations and selected member of the advisory board including the easa alrigh2t is expected to be a cornerstone in the path towards the deployment of lh2 as an aviation fuel strengthening the european research and industry leadership and consolidating the role of green airports as hubs of the h2 economy
a revolutionary tech for exceptionally efficient natural muscle tissue growth in cultivated meat applications

whilst meat demand is expected to double by 2050 consumption needs to drop by 50 to reduce greenhouse gases and preserve land cultivated meat meat products manufactured through the harvesting and proliferation of animal cells offers a feasible alternative supplying animal protein at minimal environmental costs however the industry faces significant challenges linked to production costs ability to scaleup and final product quality the main technical bottlenecks arise from the need to continuously source cells from live animals and inefficient differentiation and maturation processes that fail to achieve nutritional and organoleptic characteristics to satisfy consumers harnessing unique expertise on muscle cultivation profuse has developed the first spontaneously immortalized and stable myoblast cell line bovine with remarkable proficiency in both muscle tissue proliferation and differentiation secondly profuse has formulated a media supplement capable of driving the highly effective fusion and maturation into contractile muscle successfully mimicking natural muscle development after receiving the licensing of the patent protecting the discovery and the incorporation of our startup for boosting development and commercialization our team has established strong relationships with worldwide leading cultivated meat producers and suppliers developing initial supplement formulations for different 2d and 3d applications through this project we aim at optimizing our combined cellline supplement solution for scaleup enabling 3d production techniques up to reaching the validation in relevant environment with at least 3 potential clients while preparing the certification dossier thus bringing our combined cellline supplement solution to trl6 profuse will transform the scaleup potential and quality of final cultivated meat products fast forwarding the industry to high uptake scenarios
supramolecular photocatalytic latestage ch functionalization

organic synthesis is still one of the main limiting factors in drugdiscovery projects traditionally the generation of compounds libraries requires tedious synthetic routes to introduce modifications into the lead compound thus the implementation of new methodologies to modify drugs in a selective way in the late stages of their synthesis is highly attractivein supraphocat project several supramolecular receptors will be provided with catalytic activity and combined with photoredox catalysis to achieve unprecedent asymmetric ch funtionalization reactions with exquisite selectivity using co2 as nontoxic abundant c1 building block this ambitious project will establish new methodologies for ch latestage functionalization of drugs which is a key point towards the development of libraries of compounds according to eu green chemistry insightsthis marie sklodowska curie action will merge the expertise of the host group prof luca dellamico nanomolcat group from university of padova in co2 valorisation methods and photoredox catalysis with the expertise of the fellow on supramolecular chemistry molecular recognition and organocatalysis also this project has been designed to augment and complement the research and transferable skills sets of the fellow and will greatly enhance his career prospects to become a mature and independent scientist through the training and the research results arising the fellowship will be beneficial to the candidate the host institution and european scientific and social environmentthis research will allow a great improvement of the stateoftheart in the construction of active organic molecules through a new powerful and impacting synthetic methodology raising the standing of eu chemistry within this field at a global level hence supraphocat will constitute a significant contribution to the field and will suppose a benefit for synthetic organic chemists pharma agro and finechemicals industries in eu