Dragon09/odtu_chatbot huggingface dataset:
a toolset for hyperrealistic and xrbased humanhuman and humanmachine interactions

the concept of presence can be understood as a synthesis of interrelated psychophysical ingredients where multiple perceptual dimensions intervene a better understanding on how specific aspects such as plausibility the illusion that virtual events are really happening copresence the illusion of being with others or place illusion the feeling of being there impact xr experiences is key to improve their quality the availability and performance of current technologies do not reach high levels of presence in xr which is essential to get us closer than ever to the perennial vr dream to be anywhere doing anything together with others from any place presence will impact multiple dimensions of presence in physicaldigital worlds addressing three main challenges i how to create realistic visual interactions among remote humans delivering highend holoportation based on live volumetric capturing compression and optimization techniques under heterogeneous computation and network conditions ii how to provide realistic touch among remote users and synthetic objects developing novel haptic systems and enabling spatial multi device synchronisation in multi user scenarios iii how to produce realistic social interactions among avatars and agents generating ai virtual humans representing actual users or ai agents presence will ensure the future uptake of research results following a threefold evaluation method 1 each technology will be independently evaluated to understand its impact on the illusion of presence 2 each component will be evaluated by the integration team providing scientific and technical feedback in order to facilitate their use in each project iteration as well as beyond the project scope towards technology transfer and exploitation 3 all components will be integrated in two demonstrators professional and social setups following a humancentred design approach and ultimately evaluating the user experience
nonhermitian elastodynamics

the properties of artificial materials can be tailored to exhibit extraordinary properties by cleverly engineering their composition the development of such metamaterials is a prominent thrust in engineering today one of the greatest challenges is to engineer metamaterials that manipulate waves by design of particular interest are elastic waves since numerous mechanical applications require their control vibration isolation ultrasonography energy harvesting and cloaking to name a few the forefront of research in wave control emerged from a seemingly unrelated theory quantum mechanics with the development of its nonhermitian formalism describing nonconservative systems that exchange energy with their environment by drawing analogies between this formalism and those of classical systems researchers have discovered phenomena that defy intuition phenomena such as zero reflection and chiral absorption and have exploited them to control light sound and elastic waves can we go beyond these analogies i suggest that the answer is hidden in the tensorial nature of elastodynamics a nature that is unparalleled in other physics this conjecture is motivated by my groups recent discovery that even conservative stratified solids can generate nonhermitian features such as negative refraction and exceptional points the mechanism that obviates external energy is the coupling between shear and pressure waves that is unique to elastodynamics what happens when judiciously exploiting this distinctive mechanism together with concepts from nonhermitian quantum mechanics in tackling this question i expect to unveil novel phenomena that are inaccessible in other physics understanding the mechanics will lead to exceptional ways of shaping waves thereby benefiting engineering applications that require robust control of elastic motion
restoring movement lost to stroke

from violinists to metal welders finely tuned hand and arm movements are the foundation of craft while all of us rely on proficient use of hands for the activities of daily life yet more than 25 million people worldwide lost functional movements to subcortical stroke subcortical stroke often interrupts the communication between the cortex and the cervical spinal cord circuits which leads to permanent hand and arm paralysis the result is a vastly reduced quality of life and enormous socioeconomic burden for the affected their families and the society a treatment that can effectively restore functional movements after subcortical stroke does not yet exist still the motor cortex which orchestrates movements and the spinal cord motor circuits that directly control muscles remain largely intact we aim to reverse the hand and arm paralysis of people with subcortical stroke by developing a digital bridge that reconnects the motor cortex with the cervical spinal motor circuits this brainspine interface consists of fullyimplantable recording and stimulation systems that link cortical signals to spatiotemporal sequences of epidural electrical stimulation targeting spinal cord regions involved in the production of hand and arm movements our preliminary results in people with spinal cord injury strongly indicate that the brainspine interface can restore natural control of movement and promote neurological recovery therefore we are confident that a cervical brainspine interface can reverse hand and arm paralysis incurred by stroke and therefore become the first viable treatment option for subcortical stroke survivors beyond the development and validation of the cervical brainspine interface for stroke survivors this project will build the intellectual property necessary to secure funding that will bring this treatment into widespread clinical use
fostering sustainable balanced equitable placebased and inclusive development of ruralurban communities using specific spatial enhanced attractivenes mapping toolbox

the objective of poliruralplus is to foster a sustainable balanced equitable placebased and inclusive development of rural and urban areas through improved connections governance arrangements and integrated territorial policies that prioritise experimentation and innovation in domains that favour bidirectional urbanrural synergies and the development of a wellbeing economykey focus will be driven by foresight planning and implementation of integrated urbanrural strategiesthe poliruralplus project aims to improve the quality of life for people living in urban and rural areas across the eu by promoting coordinated and collaborative development within the regions the project will support 9 pilot projects including 8 from the previous polirural project and 1 new project that focus on developing ruralurban partnerships the aim is to increase the resilience and interconnectedness of urban and rural areasin terms of financing the project will demonstrate successful application of funding mechanisms to support these partnerships including publicprivate partnerships crowdfunding and other innovative financing models the goal is to find sustainable financing solutions that can support the longterm development of these partnershipspoliruralplus will validate an euwide regionaldriven integrated territorial planning implementation actionforesight process tool box by extending the latters innovation hub through the european digital innovation hubs using opensource system dynamic modelling a gis collaborative online service called map whiteboard enhanced by uptodate artificial intelligence and deep learning aidl applicable algorithmsthe project has an ambition to become an integral part of the new european bauhaus due to its lighthouse success of gradual buildup of handson experience using uptodate tools supporting decisionmaking process based on foresight principles
athome maximised potential dnarna detecting device

this project will develop the athome maximised potential dnarna detecting device ampd ampd is a handheld equipment free pointofcare device that can detect dnarna biomarkers in easily accessible bodily fluids such as blood nasal and saliva samples it is intended for diagnosing both infectious diseases and cancer additionally it can do it athome and early in disease progressionboth infectious diseases and cancer are leading causes of death globally in 2020 cancer accounted for 10 million deaths furthermore covid19 alone has accounted for 65 million deaths since the start of the pandemic ampd intends to significantly reduce the number of deaths for both diseases by providing a platform that can allow for ultrasensitive low cost and convenient detection first ampd can detect extremely low concentrations of biomarkers at the early stages of these diseases second ampd can cut the cost of each test from us200 commonly observed with pathological lab tests to us10 finally ampd can enable athome diagnosis with blood nasal and saliva samples thus preventing invasiveuncomfortable procedures that deter many people from getting tested until it is too late the development of such a device can enable endusers anywhere in the world to detect these diseases even before symptoms appear this can allow for early intervention before prognosis worsens thus saving lives
ancient viruslike transposons from horizontal gene transfer to the evolution of novelty

from antiparasitic toxins in butterflies to antifreeze proteins in fish horizontal gene transfer hgtthe nonsexual exchange of genes between specieshas been observed in all major eukaryotic lineages however one of its most fascinating aspects the transfer mechanism remains a mystery despite decades of research how can dna leave the donor species come in close contact with the germline of a second species and integrate in the genome of its new host our lab made a significant breakthrough in our understanding of this process that now allow us to address these questions experimentally we discovered that mavericks ancient eukaryotic transposable elements related to giant viruses and adenoviruses have mediated the widespread transfer of genes between highly divergent nematode species on a global scale the gene content of mavericks suggests that they have a dual lifestyle both as transposons and as infective enveloped viruses yet how they accomplish hgt at the molecular level is unknown having pioneered the identification of the first hgt vector in animals the objectives of the topgun proposal are to dissect the molecular basis of hgt elucidate its impact on evolution and reveal general principles of hgt across eukaryotes to achieve this i propose the following aims1 to uncover the life cycle of mavericks and reconstitute horizontal gene transfer in the lab2 to dissect the impact of mavericks and their cargos on molecular innovation and genome evolution3 to systemically discover vectors of horizontal gene transfer across eukaryotes in silicomy team and i will pursue these objectives by applying a multidisciplinary approach combining genetics functional genomics biochemistry and structural biology we believe that topgun will ignite hgt as a new experimental research field and catalyse the development of new payload delivery systems for parasitic nematodes most of which cannot be genetically modified due to their complex life cycle
engineering water repellent coatings by functional nanosponges a springboard to stable perovskite devices spike

the spike project aims at realizing a revolutionary water repellent coating as a functional barrier to encapsulate photovoltaic pv electronic devices global solar encapsulation industry massively pushed by the urgent increase in the solar energy demand is expected to reach 1137 billion by 2028 with a growing rate of 145 during the forecast period 2021 2028 solar encapsulation is key to provide excellent durability to a pv module an essential prerequisite for its commercial viability this is particularly true for the market exploitation of any new emerging solar technologies hybrid perovskite solar is an example a key player in emerging pvs and a potential revolutionary system for smart pv integration in everyday life being lowcost coloured and flexible their low durability however questions their marketable appeal spike aims to solve this issue demonstrating and bringing to the market an innovative technology based on smart nanocoatings which can revolutionize the solar encapsulation industry and beyond the coating is made of porous nanosponges with tuneable functionality transparency flexibility versatility and at reduced cost overcoming the limits of the current commercial encapsulants heavy thick costly and involving high temperature processing it is the goal of spike to unleash the innovation potential of the proof of concept by developing technically validating and bringing to the market such innovative technology by i realizing lowcost large area robust coatings with a low energy consuming solutionbased fabrication process ii integrating them in highly efficient perovskite solar modules iii demonstrating and validating a prototype in an industrially relevant environment and iv providing a reliable business model and market analysis to push our prototype to a commercial stage building the bricks for the creation of a new startup company ultimate outcome of spike
virtual tissue staining by deep learning

our goal is to create a virtual tissuestaining device to replace manual chemicalstaining techniques by integrating optics and deeplearningchemical staining of cell components plays an essential role in biomedical and pharmaceutical research and practice cell structuresof interest are highlighted using various chemical stains and imaged with the appropriate optical setup however these techniquesare often invasive and sometimes even toxic to the cells in addition to being time consuming labor intensive and expensiverecently the use of deep learning has been proposed as a way to create images of virtually stained cell structures thus mitigating theinherent problems associated with the conventional chemical staining however these methods are usually specialized for a specificapplication and thus highly dependent on the setting of the optical device used for acquiring the training datain order to make virtual tissuestaining more accessible to endusers we propose a device based on a simple optical system with anintegrated deeplearningpowered virtualstaining softwarethis is an ideal moment to enter the virtual tissuestaining market because we can gain a first mover advantage further we can takeadvantage of the fact that the tissuestaining market is expected to grow with a compound annual rate of roughly 85 until 2025 upto 3400m usd and to continue to grow for the foreseeable futureas part of this project we aim to launch the startup company iflai to commercially exploit our virtualstaining technology and theprototype we will develop with the startup iflai we aim to provide 20 jobs to universityeducated individuals in the eu within thenext 5 years iflai has already received initial funding and support from two different organisations that support and believe in itsventure
farmerfocused biodiversity and agricultural knowledge network

the beneficial links between biodiversity and agriculture have not yet been adequately communicated to farmers and foresters thereby creating reluctance in the uptake of biodiversityfriendly farming bff practices including in natura 2000 sites farmbionet will address this knowledge gap in european farming and forestry the farmbionet consortium combines the expertise of natural and social scientists farmer organisations smes ngos businesses and ministries in 13 countries 11 member states farmbionet will promote europewide knowledge exchange and integration of research findings and practices related to farmland biodiversity especially inside natura 2000 sites including those relevant to climate change mitigationadaptation and soil health it will evaluate and refine measures and develop and use crosssectoral approaches to collect and distribute at national and european level easily accessible practiceoriented and context specific knowledge on bff practices central to farmbionet is the establishment of farming and biodiversity national networks nns consisting of farmerforester individuals and organisations researchers ngos advisors and other relevant akis actors farmbionet will use these nns to gather and disseminate knowledge and information nns will use bff casestudy areas to promote exchange of traditional and evidencebased actions that benefit farm biodiversity through a cocreation and crossfertilisation process costbenefit analyses showing how biodiversity can benefit sustainable food production and development of practical decisionmaking tools will promote biodiversity with farmers and foresters and local regional and national policy makers farmbionet aims to position europe as a global leader for biodiversityfriendly farmland management practices harnessing knowledge to protect biodiversity and the ecosystem services it provides which are vital to sustainable land management and bring wider societal benefits
bioactive polyphenolic compounds from brown macroalgae a mechanistic study on pig gut health promoting effects bioalgae

modern pig production hugely depends on infeed antibiotics to control postweaning diarrhea pwd and improve pig gut health during weaning however the use of infeed antibiotics and zinc oxide zno has already been banned in europe prompting an urgent need for alternative solutions currently there is emerging interest in various bioactive compounds from brown macroalgae such as the polyphenolic compound phlorotannin pt as a potential alternative due to their diverse biological activities weaning in pig compromises not only shortterm gut health or reduces energy status or alters gut microbiota gm but also disrupts mucosal integrity increasing susceptibility to infection and negatively influencing longterm health therefore it can be hypothesized that improving immune status enhancing intestinal barrier functions and inhibiting specific harmful microbes using pt can lead to both shortterm favorable gm profile and longterm beneficial impacts on immunity and resistance against infection therefore the objectives of this study are to investigate the effects of pt on the enteric pathogen such as e coli gm mucosal immunity and intestinal barrier function and how these effects can be utilized to mitigate pwd in weaned pigs given my background and my supervisors track record in the gut health as well as the use of macroalgae in livestock as alternative to antibiotics i have firm conviction in the successful achievement of the objectives of this project the effects of pt are expected to be reflected in improved pig gut health reduced mortality and enhanced productivity in weaned pigs this has huge implications in europe to fill the vacuum created by the banning of infeed antibiotics and zno moreover this research project can complement the skills gained from my phd project by filling some of the skill gaps which are important to develop my envisioned career by strengthening my handson lab and overall research skills in pig gut health
intramermediated multiparallel mapping of signalling pathways

cellular behaviour is methodically studied using systems biology approaches that analyse the presence absence or oscillation of biomolecules to this end exogenous perturbations among others are used to alter protein expression and study their effects on cellular homeostasis however proteomes are inherently versatile and diversified by alternative splicing protein cleavage and posttranslational modifications ptm similarly the spatiotemporal formation of multicomponent complexes plays an important but less well understood role in cellular homoeostasis and disorders specific recognition of these complexes by ligands is a difficult task to solve therefore deciphering signalling cascades at the proteome and complex levels requires technologies that enable the identification of proteinbinding and inhibiting compounds that are sensitive or tolerant to ptms and can recognize protein complexes intracellularly expressed aptamers known as intramers offer a solution to this challenge the intramap project will develop generally applicable paradigms for the automated evolution of intramers and combine them with cellular screening methods in this way intramers will be identified that are optimally adapted to cellular environments and effectively disrupt signalling cascades these intramers will be used to identify signalling components and protein complexes associated with these cascades they will be applied to various cells organoids and in vivo to uncover fundamental principles of complex signalling events the project has a strong interdisciplinary focus and will open novel avenues for the analysis of biomolecules it has implications ranging from life sciences to systems biology and will not only establish intramers as a broadly applicable discovery technology to study signalling cascades on an omicslike scale but also holds enormous innovative potential for the development of novel gene therapies and future rnabased drugs
circular integration of independent reverse supply chains for the smart reuse of industrially relevant semiconductors

several products embed different types of electronic components and they are even more fundamental in some of the european strategic markets eg automotive however reference producers come from extraeu countries in the fareast side of the world eg china and taiwan trying to cope with all these challenges and the current semiconductors crisis the european commission ec published and in some cases is still working on specific eu strategiesdirectives for automotive ewaste eg digital product passport and specifically semiconductors eg european chips act however trying to make these sectors more sustainable circular and resilient it is mandatory to boost both eol strategies eg sorting reuse remanufacturing and recycling and intraeu production through innovations and investments the current international scenario represents a good chance to decouple the european economy from both natural resource depletion eg critical raw materials crms and dependency from extraeu supplies of strategic products in order to better prove what the benefits are of a joined circularresilient use of secondary resources the automotive and mass electronics sectors have been identified as the reference contexts for establishing a set of innovative solutions to this aim the circuits project will focus on demonstrate the improvement to the circularity of automotive and mass electronics sectors by reuse of semiconductors from different sources as well as support the reuse remanufacturing of semiconductors into new high addedvalue components and products in these sectors