Dragon09/odtu_chatbot huggingface dataset:
neuroclues the clinical musthave for neurologists clinical validation industrialization and gotomarket

p3lab developed neuroclues a firstofakind portable fast and easy to use eye tracking medical device that brings clinically validated eye movement biomarkers for movement disorders mds into the clinical routine of neurologists neuroclues will enable neurologists to establish their md diagnosis faster from months to days earlier and more reliably and with diagnostic grade accuracy this will enable neurologists to start patient care earlier this project aims at validating and demonstrating i the usability of neuroclues in the clinical routine with early adopter kol neurologists and ii assess its clinical value in ongoing and iii in own sponsored clinical investigation studies eu and us this is needed to convince the broad majority of neurologist of neuroclues clinical value the successful demonstration and accompanied development of our gotomarket strategy will enable p3lab to become investor ready by 2024 and profitable by 2027 with 70m arr targeted by 2030
food health and environment research infrastructures to tackle emerging priorities

this proposal systematically addresses the development provision and integration of services across the european research infrastructures ris landscape that the scientific community can use to investigate the effects on health and the environment that artificial materials including plastics micro nano and biotechnological materials can have exposure to such materials may occur as a result of their intended use eg food packaging or at the end of their lifecycle eg plastic wear these services which are relevant to several areas of important societal and economic impact are expected to span multiple scales and disciplines including highquality metrology structural biology microbiology and ecotoxicologythe main output of this proposal will be a thorough overview of extant service offer by european ris with respect to questions from stateoftheart of scientific research in the aforementioned domains fheritale will identify common strategies for the coordination and optimization of services at different ris geared towards increasing the accessibility of relevant technologies in parallel it will identifty those service and technology gaps that are hampering highimpact research and preventing a timely assessment of the repercussions of new materials on health and the environment these gaps constitute highpriority areas for future development fheritale will design a coordination framework for the ris to drive these key technological developmentsthe technological focus of this application includes emerging areas of research for which international interest is rapidly growing the interdisciplinary nature of the cluster of identified technologies will connect health food and environment research constituting one of the first examples of practical application of the one health approach this coordination effort will also serve as a fertile ground for further interdisciplinary research among ris from the hf and other domains
development of a photoelectrochemical device for ammonia production

the growing world population is pressing on an increasing global food and energy demand and simultaneously contributing to an unceasing rise in carbon dioxide emissions in this context finding inexpensive and fossilfree pathways to supply energy and food has become one of the most critical challenges of this century on this scenario ammonia nh3 is envisaged as a zerocarbon fertiliser fuel and energy store with a potential key role in the transition towards a lowcarbon economy demonia is a high gain proposal to address the aforementioned challenges by means of the development of a scalable and environmentally friendly photoelectrocatalytic device for the production of solar ammonia this key platform molecule will be produced using a new generation of hybrid heterostructures based on conjugated porous polymers cpps which have not been studied for nh3 production until now these materials are expected to outperform conventional photoelectrodes leading to higher n2 conversion to ammonia demonia project will evaluate the feasibility of this novel photoelectrochemical solar ammonia approach with the aim of accelerating the development of this technology for a nearfuture access to the market the success of this proof of concept will have important commercial implications in a wide range of energetic and environmental research areas energy sector agriculture transportation chemical and pharmaceutical industry besides the strong inter and multidisciplinary approach chemical physical engineering and materials science of this proposal is expected to impact on several fields from fundamental research to applied investigations concerning renewable energy productionthe transfer knowledge plan will be a vendor ip strategy based on the information obtained by previous contacts with industrymanufacturer holders with interest on this innovative technology it implies effectiveness patent transfer of knowledge and dissemination
a privacy layer to power all research and ai workflows

sarus will bring to market a privacypreserving data solution for all research and ai projectsby leveraging generative ai and privacy research differential privacy the solution enables researchers and data scientists to leverage private data assets without seeing them it acts as a protection layer between the data source and the scientist that guarantees the privacy of any computation it supports a broad range of analysis from analytics to ai and blends effortlessly into existing workflows and it infrastructuressarus bolsters data security and privacy streamlines compliance processes and unleashes the full potential of data for research and innovationwe have already demonstrated the potential and benefit of this approach with successful paid pilots with hospitals healthcare organizations financial services companies and smart cities playersthis projects will industrialize and robustify the solution expand it to new forms of data and types of analysis eg llms to support any data workflow in a privacypreserving waywith sarus all data assets will be available to fuel innovation growth competitiveness job creation and societal progress without any compromise on citizens fundamental rights
thrust substituting helicopters with climatefriendly fixedwing drones for infrastructure inspection

in eu alone total length of overhead electricity lines reaches staggering 53 million km that is more than 5 million km of potential fail points that need to be inspected and maintained in order to ensure the reliability of electricity supply currently these inspections are carried out by helicopters or walking inspection crews however the walking crews are slow and inefficient while helicopters are expensive and damaging our climate helicopters consume 60 liters of fuel per hourour solution substituting helicopters and walking crews with our new generation unmanned aerial vehicles uavs equipped with lidar rgb and thermal cameras combined with machine learning ml powered analytics that can quickly and accurately identify defects and faults in electricity grid elements our team have developed a drone capable to carry combination of sensors at the same time designed to fly slow and at low altitude for higher data quality and inspecting up to 300 km per day thrust drones are capable to fully substitute walking inspector crew and helicopters for infrastructure inspections at a fraction of a cost furthermore our drones emit 171 times less co2 per km than helicopters and 10 times less than cars our drones have potential to cut eu co2 emissions by 12 million tonnes of co2 annuallywith the help women techeu we will prepare for the next fundraising round expand our innovation partner network and launch a media campaign to encourage more women to join aviation industry this project objective is to position our company to be the catalyst for higher women involvement in aviation industry through leading by example as well as increasing thrust scalability to become leading deeptech startup in dronebased infrastructure inspections
mixotrophy an uncharted carbon flux in the plant world

plants need light to grow they use energy from sunlight to produce organic carbon however new findings including my own work now hint that up to 35 of all plant species can also obtain carbon from rootassociated fungi when light availability is insufficient for growth this calls into question much of what we thought we knew about how plants survive in the understory the goal of this project is to determine the frequency and magnitude of this newly discovered form of mixotrophy in our terrestrial ecosystems i will achieve this exciting goal by working at the intersection of physiology ecology evolutionary and molecular biology the vast majority of land plants transfer part of the organic carbon they produce by photosynthesis to rootassociated arbuscular mycorrhizal am fungi which help plants to take up nutrients and water from the soil my previous findings demonstrate that this carbon can be subsequently taken up by rare nongreen plants that tap into the same fungal network this paved the way for the discovery of am mixotrophy in which common green plants take up carbon from am fungi however the plant and fungal diversity involved in am mixotrophy are unknown likewise the environmental drivers that influence carbon uptake have never been measured nor do we know about its evolution and geographic distribution this is problematic because we are unable to quantify or understand the role of am mixotrophy in our natural world with field studies laboratory experiments and genetic screening of natural history collections i will 1 identify am mixotrophic plants and their habitats 2 reveal environmental drivers that regulate carbon uptake 3 expose fungal networks that sustain am mixotrophs and 4 measure the magnitude of am mixotrophy across evolutionary and geographic scales this will lead to a fundamental shift in our understanding of carbon uptake by plants with profound effects for carbon cycling models and conservation
viking iron production in iceland a new model of norse iron supply and circulation in the north atlantic

iron was a strategic resource in ancient societies and is still of great importance today this metal was notably mass produced during the viking age and traded over long distances between the different norse settlements this project aims to investigate the provenance of viking iron artefacts and to develop a new model of the dynamics of iron movement in the north atlantic region during the viking age in norse society iron was used to produce everyday tools as well as weapons and boat rivets this metal is thus intrinsically linked to the formidable viking expansion the numerous remains of iron production in the scandinavian homelands led most historians to consider that viking iron was almost exclusively produced in norway and sweden however this hypothesis fails to explain the growing number of archaeological evidence attesting to intensive iron production in iceland exceeding the local needs to investigate the fate of this icelandic iron production in the network of viking iron circulation we propose a novel multiproxy tracing approach combined sr fe hf and nd isotopes and trace element analyses will be performed on metallurgical remains from iron smelting sites ie technological sources and archaeological artefacts we will determine a specific multiisotopic and elemental signature for each region of iron production against which the composition of the objects will be compared strontium isotopes are highly likely to fingerprint iron from iceland because of its geological singularity to complement this hf nd fe isotopes and trace elements will be used to refine source distinctions these results will be compiled to produce a multitracer objectsource matching map and propose new iron flows patterns during the viking age finally this model will be used to address the question of a possible spatially specialised norse iron industry and improve our understanding of the viking diaspora that first connected europe to north america
new improved eusst missions and services horizon europe top1

this horizon europe grant is to be understood within a wider context on eusst where other grants are being executed simultaneously with the common objective of improving the eu autonomy on space surveillance and trackingin particular this top focuses on keep the knowledge and capabilities of europe on the space surveillance and tracking domain at the leading edge adapt improve and evolve the current eusst initial services collision avoidance fragmentation reentry portfolio to future user needs and space environment improve the overall performance of the eusst services and ensure in the longterm a high level of performance and appropriate autonomy at union level identify and define new missions and services eg debris mitigation debris remediation explore the implementation of new services in complement of the three existing ones support the predevelopments and endtoend early demonstration of new sst servicesthe starting point of these activities is the output of 23sst201820 which constitutes the state of the art on sst matters
reconnect research communication for active learning

researchers worldwide are struggling nowadays to solve some of the critical issues which pose a threat to our future life on earth while everyone heard about the climate change smart cities freshwater and ocean pollution soil degradation which conduct to poor quality of food or cancer but most of the time only with respect to disasters or an uncertain future the researchers are actively involved into identifying practical solutions for all these threats developing devices and systems to monitor control and diminish their effect and to cure people and earth these missions will have the chance of becoming effective only by reconnecting the researchers to the society by developing a mutual respect and understanding one needs a will to listen to be open to the new and to explore as such we propose the adoption of a special life strategy that of continuous and active learning in which all those involved scientists communicators or the general public are active learners interacting with each otherthe consortium is made up from 5 research institutes the largest and most prestigious in the country 4 universities with high scientific expertise but also including journalism faculties and one public scientific body that have been participating in previous research outreach events and coordinate some of the largest stem educational networks teachers and pupils derived from the european programmes by organization of 20 night events yearly also in rural areas and a strong involvement of researchers at school along the 2 years project implementation we are confident in the strengthening of the science communication and educational programs already developed increasing meanwhile the number of researchers involved in outreach activities these allow us to look to the future with new hopes of an active and cultured society towards solving the humanity issues through science and awareness
the sleeping embryo

the implantation of the blastocyst into the uterine wall is a key step of the reproductive cycle which mediates the connection of the embryo to the maternal tissues during the early stages of pregnancy however in some species including the house mouse this process can be put on hold while the embryo falls into a reversible state of suspended animation known as diapause the dormant embryos can reside in a deep sleep over extended periods of time eg bypassing unfavourable environmental conditions without compromising their developmental potential although the maternal hormonal control of implantation and the process of transient mouse embryogenesis have been intensively studied the embryonic diapause is still an extremely enigmatic state several lines of evidence based on my preliminary data suggest that diapause is not a stasis but instead is a dynamic process with underlying mechanisms that can appear redundant during transient embryogenesis here i aim to decipher the cryptic embryointrinsic mechanisms of embryo dormancy using the mouse as a model system i will elucidate the cellular processes that coordinate and capacitate the embryo for diapause on epigenetic transcriptional and cell signalling levels using interspecies chimeras and blastoids i will extend my analysis to nondiapausing species and artificial embryolike structures thus by manipulating the flow of embryogenesis i will uncover hidden dormant mechanisms safeguarding the developmental potential of the early mammalian embryo
oxytocin regulates marmosets affiliation and vocal communication

primate social interactions rely heavily on visual and acoustic signalling yet little remains known about how social context affects how vocalisations are perceived and produced and the neural mechanisms that support this this process given the complex dynamics that typify primate societies addressing such questions remains of critical importance to elucidating the mysteries of the primate social braini hypothesize that oxytocin ot a neurohormone that regulates social behaviour and a promising therapeutic target for psychiatric disorders influences contextdependent effects on primate vocal communication notably by acting in higher order brain regions involved in vocalisations and encoding social informationi propose to explore the neural basis of socially adapted acoustic communication to do so i will record vocalisations from marmoset monkeys a highly vocal primate and promising model for neuroscience in different social contexts designed to elicit positively or negatively valenced calls between differently affiliated monkeys importantly these experiments will happen in seminatural conditions focusing on freely moving animals expressing their normal behaviours within the colony this is a highly novel approach that starkly contrasts with classical taskbased experiments additionally using modern tools including high throughput neurophysiology chemogenetics and intravenous viruses i will manipulate ot neurons activity while recording from hundreds of neurons this will enable analyses focusing on neural populations instead of single units all wireless and without interfering with the animals behavioursthis multidisciplinary approach will allow me to uncover some fundamental aspects of how the primate brain encodes natural conversations and adapts its response accordingly to the social context moreover i will for the first time study how endogenous ot controls social behaviours in primates
innovative cryopreservation methods for chicken germplasm

poultry products are the most consumed source of animal protein globally to enable current and future poultry genetic improvement towards climate adaptation and sustainable farming practices to meet future nutritional demands it is essential to maintain and make available the existing genetic diversity within and between the breeds gene banks can assist in conserving genetic diversity and reintroduction and implementation of important traits or genetic variants into poultry lines the main goal of cryochick is to develop effective cryopreservation methods for exsitu conservation of male and female chicken germplasm existing strategies and methods for gene banking of chicken reproductive material are not adequate for several reasons such as poor fertility rate of cryopreserved semen the contraceptive effect in hen of glycerol the most effective sperm cryoprotectant the current impossible cryopreservation of chicken oocytes due to its telolecithal structure while semen alone does not capture genes of mitochondria and the w sexchromosome therefore new effective cryopreservation methods for both male and female chicken germplasms as well as new strategies for maintaining and using the stored cryopreserved materials for costeffective gene banking are required the methods and strategies developed will likely also benefit other poultry species and conservation of wild relatives cryochick comprises a high level training program for dr bernal and different coordinated actions performed by prestigious institutes from different countries and research fields promoting international collaboration interdisciplinarity and transfer of top knowledge to the private sector the european competitiveness will be reinforced by addressing with the highest level of knowledge important global scientific and societal concerns such as maintenance of biodiversity and food security both serious threatened by climate change
digital assets and tools for circular value chains and manufacturing products

dacapo aims at establishing a systematic approach enabling the creation of humancentric digital tools and services for improving the adoption of circular economy strategies along both manufacturing value chains and products lifecycles design and engineering manufacturing use phase and end of life these tools and services focused on the creation of new digital assets aibased systems and the application of process and product digital twins will greatly improve sustainability efficiency and use of imported and crm in manufacturing towards digitalenabled industrial sustainability and resilience the backbone of the project will be a new methodological approach supporting decisionmaking considering business models material flows and circular strategies along the manufacturing value chains digital product passports and a circular economy decision support system will be developed as highlevel tools facilitating the trustful exchange of assets the selection of optimum circular stock management strategies and tools and the definition of informed and coordinated products lifecycle management decisions in a safe reliable and agile way a modular digital thread concept will be developed as a normalized method for orchestrating the gathering and contextualization of data at different points of the product lifecycle enhancing data availability for the definition of indicators and optimisation criteria on top of that dacapo will develop a digital architecture aligned with interoperability and connectivity standards guaranteeing endtoend horizontal and vertical integration boosting data sharing and exploitation under the eu data spaces framework and maximizing replicability potential a consortium of 8 top research institutions and 6 relevant industry partners backed by 1 eu association for technology standardisation will demonstrate dacapo on 3 relevant and eu critical value chains production environments aeronautics electronics and logist