Dragon09/odtu_chatbot huggingface dataset:
reactivity and transport of hollow magnetic particles explored with microfluidics

rtmap will develop novel hollow iron oxide particles and assess their reactivity stability and mobility under flow through porous media such hollow magnetic particles hmps have aroused great interest for their potential to encapsulate and control reagent release for environmental remediation andor heterogeneous catalysis most available reactivity assessment studies rely on the interpretation of breakthrough curves measurement at the outlet batch tests or column experiments and do not allow a direct visualization of pore scale transport and reaction phenomena rtmap will develop novel microfluidic cells providing a new window on coupled flow and reaction processes at the microscale a key to modeling and predicting macroscale reaction rates the combination of complementary expertise of the fellow material synthesis and characterization and the supervisor and cosupervisors molecular geochemistry reactive transport in porous media microfluidics will offer a unique opportunity to address these emerging scientific questions we will thus fabricate microfluidic cells providing spatially resolved concentration fields under flow through reactive porous media cuttingedge spectroscopic techniques will be used to investigate molecular interactions between reactive particles and two types of fluorescent compounds the first is a fluorescent probe fluorescein used to functionalize particles and make them traceable by imaging in microfluidics the second is an environmentally relevant antibiotic ofloxacine to study the reactive properties of hmps with emerging contaminants advanced microfluidic devices and fluorescence imaging will provide the first spatial resolved images of hmp concentration at microscale under different flow rates and solution chemistry rtmap will thus lead to key innovations at the interface of environmental chemistry geosciences and microfluidics placing the fellow on a strong footing to find an independent research position
legumecereal intercropping for sustainable agriculture across europe

as conventional cropping systems face deterioration of soil quality loss of biodiversity and declining ecosystem services there is an urgent need to change practices to more sustainable yet productive systems intercropping enhances biodiversity maximizes land productivity and optimizes biogeochemical cycles in agroecosystems but is lacking acceptance from european farmers legumebased intercropping takes advantage of biological diversity and synergistic effects between companion plants while reducing external inputs a major objective of leguminose is to identify the obstacles to intercropping and enhance farmers acceptance by providing knowledge and demonstrations that promote economic environmental and social benefits of legumecereal intercropping leguminose will assess intercropping potential by focusing on pesticide reduction plantmicrobe mediated element cycling soil health improvement and crop quality and health to overcome barriers to intercropping implementation we will establish a network of six field trials and farm labs 20 farms in each country 180 onfarm trials in different pedoclimatic zones across europe it de dr es pl cz uk egypt and pakistan furthermore we will integrate remote sensing and crop modelling to survey fields upscale the fieldscale results and create a webbased decision support system on intercropping in collaboration with various stakeholders legumeintercropping systems economical ecological and social gains will be assessed and disseminated with international outreach from farmlevel to policymakers we will recognize and involve the whole value chain to explore and test innovative marketing strategies for the products of intercropping leguminose will contribute to the ecological intensification of european agriculture by providing sciencebased farmerled and economically viable transformations for legumebased intercropping systems
ellphaio accelerate bias tackle and commercial footprint

ellpha is a french company founded in june 2018 by two women founders stephanie creff ceo and brigitte ricou bellan advisor they were joined at the end of 2021 by cyrille duverne cooellphas vision is to create a fairer more diverse world using data and smart technologyellphas goal is to empower people detecting and acting on bias to create a better world ellphaio wants to drive results fast when progress on diversity equity and inclusion has been slowly incrementedellpha is a social science model designed into an ai the deeptech innovation resides in the ai bias detection enginetm it offers unprecedented ability to uncover and surface hidden bias stereotypes in real time and across growing data setsthe company differs from its competitors because it addresses the full talent flywheel it is agnostic and pure player and it is designed to improve existing tools and talent management processes ellpha tackles root cause not symptoms it offers a scalable and dynamic solution and is not looking for neutrality but for diversity and contextualizationto date ellphaio offers a first commercial version of its solution talentuum and of its ai bias detection enginetm it provides all managers with live coaching to avoid potential bias risks with opportunities to selfreflect and amend their content it also provides hr leaders with aggregated insights and analytics providing a picture of potential bias across segments and groupsellphas challenge now relies on deepening its hightech solution and accelerating its commercial development being awarded by the women tech eu program would help the company to overcome some of its clients challenges easing the appropriation of the solution by the development of a web based onboarding and trial package as well as integrating the saas solution with a key hr software of the market the coaching and mentoring would help the founders to make their message more understandable by their clients
detailed 3d building models automatically generated for very large areas

in the erc project urban modelling in higher dimensions umnd we developed a solution for detailed 3d building models automatically generated for very large areas 3dbag this prototype was applied to generate detailed 3d models for all 10 million buildings in the netherlands such a digital twin of built objects provides a valuable data source and simulation basis for professionals working in planning design construction energy real estate as well as for environmental impact studies on noise floodings wind flows air quality and urban heat islands 3d models are already used in specific domains but it takes a lot of effort to generate suitable 3d building models for a given application due to the required manual editing therefore detailed 3d models are rarely available for large areas regions or nations the solution lies in the unique method we developed which enables to generate highquality easytouse 3d building models fully automatically at national scale to be used without any technical or legal restriction this will be a breakthrough for the use of 3d data in current and new applications with the betarelease of the dutch 3dbag and the subsequent wide adoption and application of it by industry and government the effectiveness of 3dbag has been demonstrated this poc aims to further advance 3dbag from the current trl6 to trl9 firstly we will make 3dbag technically sustainable by addressing issues to achieve even higher adoption supporting more height data sources as available in other countries and to prepare for the maintainability and performance of our method in an operational setting secondly we will explore how to best ensure the economical sustainability of 3dbag by clarifying the ipr and licencing strategy and assessing the market potentials extending our current relations the users interest to pay for value added services and possible international expansions
morphing tubular structures for adaptive biomedical devices

morphing tubular structures are extensively used in interventional medical devices eg stents current solutions lack adaptability to complex geometries and to patientspecific needs stripeomorph proposes the use of devices with superior morphing capabilities bioinspired by motile microorganisms previously investigated in the erc adg micromotility and based on the concept of morphingbysliding of parallel strips
creative drivers for sustainable living heritage landscapes

palimpsest takes inspiration from the original meaning of the greek word palimpsestos again scrape which describes the process of the writing practices over papyrus existing text was scraped and washed off the surface resmoothed and the new literary material written on the saved material palimpsest adopts this rewriting perspective and grounds it on a living heritage approach palimpsest envisages regenerating the lost sustainability wisdom underlying the production of heritage landscapes through the activation of cocreation processes involving creative actors technical stakeholders and civic society here architecture design and art practices will dialogue with placespecific needs and broad systemic challenges to imagine new scenarios and experiment with innovative practices connecting human actions landscape heritage and sustainability objectives such experiments will envision novel landscape scenarios aiming at producing dedicated landscape services inspired by the generation of beneficial outcomes on ecosystem functions which the creative contribution of ccis will empower human practices will arise as relevant agents of a new sustainable palimpsest process palimpsest will integrate the aforementioned landscape services in environmentalsensitive solutions with sustainable finance infrastructures to support the sharing and circulating of positive externalities at different levels among the landscape service actors and communities palimpsest revolves around three pilots with strong cultural identities and relevant environmental problems lodz pl a unesco city of films fighting the highest air pollution levels in europe milan fringes it traditional agricultural landscapes struggling with unsustainable water use jerez de la frontera es an andalusian wine landscape and vernacular site challenged by renewable energy production facilities
enhancing research capacity at the geological survey of estonia to accelerate the countrys transition to green energy egttwinn

the proposed horizonwidera2021access03 twinning project aims to enhance research and technical capacity at the geological survey of estonia egt to accelerate estonia transitions from fossil fuel energy to green energy the capacity building will be mainly focussed on developing stateoftheart geological geochemical and geophysical survey skills data management workflows and subsurface modelling capability for exploration and geological resource assessment of european critical raw materials and geothermal energy as a future potential green energy source for estonia the egt geological capacity enhancement will be implemented via range of joint activities such as scientific conferences and exchanges as well as through delivery of specialised training programmes provided by three leading geological surveys in europe the geological survey of finland gtk the british geological survey ukribgs and the geological survey of denmark geus the project will contribute to the development of multidisciplinary research and innovation in geological studies in estonia and enables egt to enhance the scientific excellence of its personnel and to collaborate with experts from leading international research institutions one of the project priorities is to support earlycareer researchers at egt who will gain stateoftheart experience in the geology fields crucial to estonia
connedted health ecosystems via open innovation

the development and uptake of novel digital technologies in healthcare are associated with several barriers such as expensive and risky development processes quality and security requirements and fragmentation in regulatory and reimbursement schemes open innovation is an approach designed to foster innovation processes increase efficiency and reduce costs by bringing together various stakeholders of the healthcare ecosystem to create a supportive environment for innovation that helps overcome existing barrierscohesio intends to create an interregional open innovation environment for digital health by interconnecting the regional ecosystems of norte from portugal malopolskie from poland and attica from greece we aim to increase the connectedness of these regions by introducing common tools for collaboration and networking to improve the efficiency of healthcare innovation by identifying possibilities for joint interventions eg the creation of an interregional virtual living lab and to support the transfer of best practice innovation support schemes via a bottomup cocreation process involving a diverse mix of innovation stakeholders joint actions will be identified and their implementation will be secured by the engagement of public authorities cohesios associated partners being responsible for relevant innovation strategies and funding programmestu delft a central actor of a leading and wellinterconnected innovation hub will facilitate the mapping of common challenges identifying synergies and complementarities in regional capacities and designing joint interventions with a methodology emerging from the eit health drive ecosystem development programbeing one of the regional nodes of eit health innostars provides the framework for cooperation and ensure the europeanlevel dissemination and exploitation of cohesio results and the extension of the applied methodology to further european ecosystems
transforming cryogenic optics for cosmic microwave background experiments

future experiments mapping the cosmic microwave background cmb are designed to revolutionize our understanding of the infant universe the standard model of particle physics structure formation and the nature of dark matter a key effort involves constraining or detecting the energy scale of cosmic inflation a detection would mark a watershed moment in cosmology and highenergy physics but in order to push constraints significantly past current limits we need a dramatic change in instrument characterization capabilities the primary focus of cmbeamto address this challenge we propose to construct a novel cryogenic holography facility for the purposes of testing optical systems of current and future experiments observing at microwave frequencies 40400 ghz we will use this facility to develop neverbeforeseen optical measurements that are critical for the success of nextgeneration experiments studying the cmb as part of this program we will perform warm and cryogenic 4kelvin holography measurements of a complete reimaging optics tube for the simons observatory large aperture telescope the flagship cmb experiment of this decade in a complementary effort we will lead an ambitious analysis and calibration program for the simons observatory which will deploy 60000 cryogenically cooled detectors three times the number of currently fielded detectors globally in a site located 5200 m above sea level in the atacama desert chile finally we will develop algorithms that enable the design of novel freeform asymmetric optical systems that can greatly extend the scientific reach of future largeaperture telescopes such as upgraded version of the simons observatory and the cmbs4 experiment
targeting cardiac fibrosis with next generation rna therapeutics

the aim of fibrex is developing a novel highly innovative and close to clinical readiness noncoding rna ncrnabased antisense oligonucleotide therapeutic for the treatment of heart failure hf derived from cardiac fibrosis hf is the most common cause of morbidity and mortality with pressing social and economic burden hf remains a deadly disease with no curative treatment underlining the need for innovative therapeutic strategies the revolutionary technology we are proposing acts by reversing cardiac fibrosis the main driver of hf development and progression the excess fibrotic tissue leads to continous stiffening and impairment of the heart muscle in our prior work ncrna meg3 was identified as the most promising target expressed mainly by cardiac fibroblasts and by consistent transcriptional dysregulation in hf models the critical role for meg3 in cardiac fibrogenesis was validated both in vitro and in vivo and a lead compound targeting meg3 showed promising efficacy in relevant models human tissues and excellent exploratory safety data we propose a development project for an antimeg3 inhibitor to reach close to clinical readiness by completing nonclinical pharmacodynamic and safety studiesthis work will be carried out by an experienced team headed by prof thum with a track record of discovering and licensing various ncrna inhibitors programs and creating a clinical stage spinoff company cardior reaching phase 2 development and series b funding we are confident that our technology with the requested support will be further advanced into an innovative novel drug candidate and driven by the substantial value increase the project will be transitioned into a spinoff drug development or a licensingdeal with the industry the development of the unique rnabased antimeg3 therapeutic approach for hf derived from excessive fibrosis offers a new opportunity to revolutionize medical practice reduce health care costs and improve patients life
modulating cancer therapy response using bacterial extracellular nanovesicles

our bodies are home to trillions of bacteria emerging evidence from patients and mouse models indicates that the hostbacteria interplay determines the development and course of infectious diseases chronic diseases such as inflammatory bowel disease as well as the response of tumors to therapy i hypothesize that bacteria direct this interplay by among other means various messenger substances packed in nanometersized particles also called vesicles that they release although this phenomenon has been described long ago its biological significance in the hostbacteria interplay during the disease course of patients remains largely unknown recently my research group pioneered the discovery of gutderived immunomodulatory bacterial vesicles in the systemic circulation of nonsepticemic patients including cancer patients the overall scientific objective of this erccog project is to map bacterial vesicles in body fluids and investigate how they influence the disease course of patients these insights can contribute to the development of diagnostic or therapeutic applications
spintop

there exists a class of important computational problems that conventional computers are unable to address with reasonable efficiency such combinatorial optimization co problems are pervasive in a wide range of critically important sectors of society eg in business operations manufacturing and research including manpower scheduling vehicle routing ic circuit layout protein folding and dna sequencing efficient bigdata clustering election modelling network diagnosis modelling molecular dynamics discovery of new medicineschemicalsmaterials and so forth at present the co market size is of the order of 1b and is expected to exhibit a 56 market growth rate with a 2030 market size forecast at 50b since conventional computers are ineffective in handling large co problems dedicated hardware both quantum and quantuminspired are intensely researched and developed worldwide a quantuminspired alternative socalled ising machines has been developed over the last 20 years by dwave in superconducting technology and is commercially available however being a superconducting technology it suffers from operation at 20 mk requiring 25 kw of cooling power little hope for much miniaturization of the complete system today about 30 m3 and extreme cost 10 m per system clearly there is a need for a fast scalable energyefficient and affordable ising machine in dedicated hardware without any of the severe drawbacks of the dwave technology this is the problem that spintop wants to address spintop will deliver fast scalable energyefficient and affordable ising machines based on networks of spin hall nanooscillators shnos pioneered by the applicant j in his ongoing erc adv grant topspin the proposed technology has tremendous breakthrough innovation potential and will aid in solving societal challenges related to almost all un sustainable development goals
brain mechanisms of conscious processing from correlates to signatures

when we are awake part of the information processed by our brain becomes conscious so that we can acknowledge and report it despite important advances there is no consensus on what brain mechanisms underlie this phenomenon according to some models we become conscious of a stimulus when information gets integrated across different sensory areas for other conscious processing only arises when sensory representations are made available to the executive system with this project i explore a third possibility that the core mechanisms of conscious processing can actually be distinguished both from sensory and executive processes such experimental dissection is made possible by two new approaches developed by my team the first approach allows detecting brain dynamics that are characteristic of conscious processing independently of whether a task is required on the stimulus or not thus dissociating conscious processing from executive functions the second builds upon the retroperception phenomenon in which we trigger conscious access at an arbitrary latency after the disappearance of a stimulus thus desynchronizing conscious access from sensory processing i will jointly leverage these two approaches through a wide range of complementary techniques experimental psychology functional mri electro and magneto encephalography and human intracranial recordings experimentation will go hand in hand with the development of a major update to current neurocomputational models of conscious processing to explore the computational properties of such core system for conscious processing finally this research should reveal much longedfor neural signatures of conscious processing i will aim at operationalizing these signatures for the diagnosis of conscious access in noncommunicating patients and for starting the exploration of how a conscious stream emerges from these momenttomoment conscious access events