Dragon09/odtu_chatbot huggingface dataset:
photoinduced heating of lithiumion batteries for low temperature operation

lithiumion batteries libs are currently the most versatile allpurpose energy storage solution however lib performance is strongly affected by temperature in particular at subzero temperatures lib performance is dramatically reduced this is detrimental for lib deployment in cold climates found in northern europe or highaltitude mountainous regions and hinders their widespread use in airplanes highaltitude aerial vehicles and military and aerospace applications the pluto project aims to develop a new viable approach to improve lib performance at low temperatures to this end the pluto project will forge a photoinduced heating route for low temperature operation of liquid electrolyte batteries by incorporating insitu synthesized noble metal nanoparticles suspended in the electrolyte harnessing the nanoparticles capability to efficiently and quickly heat up when illuminated by light moreover with a proper distribution of nanoparticles uniform heating will guarantee a safe operation of the cell the pluto project aims at achieving a firsttime demonstration of photoinduced heating in a liquid electrolyte battery by using a transparent electrochemical cell with a lifepo4 cathode chosen due to its recognized stability at extreme temperatures a balanced approach between computational modelling chemical synthesis fabrication and characterization will be implemented to investigate the influence of photoinduced heating in the electrochemical processes of the lib cell and identify design rules for a suitable practical implementation in industrialcommercial applications finally the research proposed within pluto is strategically positioned at the intersection between the opticalthermalelectrochemical fields and provides an excellent opportunity for the researcher to come out as a leading figure at the forefront of battery research contributing to european competitiveness in the battery field
de novo construction and evolvability of minimal lifelike systems

the de novo creation of living systems is a longstanding dream of humanity to realise this dream we need a clear conceptualisation of the goal and the experimental means to put it to practice we think now time is ripe to make a serious attempt there is emerging consensus that a minimal living system should be outofequilibrium and selfsustaining have metabolism an inheritance system a boundary to keep the constituents together and that a population of such systems should be able to undergo darwinian evolution the aim of this proposal is to develop for the first time synthetic chemical systems with all of these featuresdue to its very nature minilife is standing on two equally strong feet chemistry and biology the strongest link between them is autocatalysis which allows reproduction our approach to creating the first artificial chemical living system takes the following steps 1 identification of new and development of existing autocatalytic supersystems that function as chemical and informational replicators 2 coupling of metabolism with chemical replicators 3 coupling of autocatalysis to compartment growth and division 4 synthesis of a chemical supersystem comprising all three components replication metabolism and compartmentalisation 5 demonstrating minimal darwinian evolution upon subjecting the systems synthesized in 13 to outofequilibrium selection regimes 6 approaching a minimal living system by enhancing of the evolvability of the triple systems developed in 4we have assembled a strong consortium that brings together pis of previous erc advanced grants in three key areas to be integrated ashkenasy and otto bring expertise in synthetic chemical selfreplicating systems griffiths brings expertise on compartmentalisation using microfluidics and szathmry is a leading expert on theory of replicator evolution and computational modellingsuccess would constitute a landmark achievement in basic science
identifying chloroplast ribosome rescue mechanisms under genetically induced and environmental stresses

photosynthesis produces all organic material on earth in plants photosynthesis depends on active protein synthesis in chloroplasts to set up photosynthetic complexes due to their endosymbiotic origin from cyanobacteria chloroplasts contain an independent genome and internal transcription and translation machinery with bacterial type 70slike ribosomes ribosomes may stall due to transcription errors misprocessed transcripts translation mistakes missing trna mutations or strong mrnafolding ribosome stalling ties up the translation machinery it is persistent at trace levels but can be exacerbated by environmental stress therefore ribosome rescue mechanisms have evolved in all life domains to resolve stalled ribosomes despite its critical role in maintaining photosynthesis and extensive study in eukaryotes and bacteria little is known about ribosome rescue mechanisms in chloroplasts in this project we will characterise chloroplast rescue factors first we will examine arfb the only known ribosome rescue mechanism ortholog found in chloroplasts by exposing arfb knockout mutants to translationstalling inducing stresses investigating conserved protein motifs subcellular localisation and overexpression additionally we will study ribosomestalling effects on chloroplast translation photosynthesis and metabolism by genetically modifying the chloroplast translation machinery finally we will directly search for novel ribosome rescue factors by identifying proteins physically engaged with stalled chloroplast ribosomes and evaluating their functionelucidating chloroplast ribosome rescue mechanisms will improve our understanding of the complete photosynthesis support apparatus and inform future biotechnology and crop improvement following this fellowship i will leverage the knowledge methods and transferable skills i acquire to study chloroplast genetics translation and nuclearchloroplast interactions in my future lab
optimization of surface multichannel electrode arrays and motor unit extraction in underrepresented populations

the motor unit mu represents the final common pathway consisting of the motor neuron and all the muscle fibres it innervates force is controlled by recruiting mus or modulating their discharge rate traditional mu behaviour investigations use intramuscular electrodes and signal processing which identifies only a few mus close to the electrode recently highdensity surface electrodeshdsemg allowed for mu identification noninvasively but it has limitations decomposition algorithms da can with validity and reliability identify mus but this is primarily in healthy young males greater adipose tissue thickness increases signal filtering leading to a lower amplitude mu action potential which is more difficult to detect with the current das this challenge has left a knowledge gap in the study of mu behaviour in underrepresented populations urp clinical female obese this fellowship aims to optimize the stateoftheart technology of hdsemg and da for a more diverse population i aim to 1 identify limitations of hdsemg and da in urps 2 adapt electrode configurations for urps and 3 optimize da for individuals across urps this project is pertinent as a large sector of the population is not studied hindering mu behaviour research progression i will focus on urps where mu identification is challenging i will fill this knowledge gap to allow the study of mu behaviour and assessment of all populations adapting this noninvasive technology is an important innovation which may be used as a model for diagnosis in clinical populations the quality and success of this project are ensured by collaborations between myself and experts in signal processing my supervisor dr negro and a company leading in multichannel electrode design their knowledge and expertise along with the facilities will guarantee the success of this project the training will provide me with substantial hard and soft skills to become an independent translational scientist
safe sustainable and high performance adhesives and coatings from industrial softwood bark

adhesives and coatings are an integral part of consumer products used in our daily lives today the vast majority of adhesives and coatings on the market are formulated using fossilbased and harmful chemicals which conflicts with the eulevel goal of reducing our dependency on nonrenewable resources and protecting the health and wellbeing of citizens and the environment the superbark project will exploit natural components in softwood bark a major industrial side stream of forest industry to develop 95 biobased adhesives and coatings for wood panels and packaging paper with the functional safety and sustainability standards required by the industry and consumers the project partners will deliver this through 1 extraction of polyphenols from bark using a novel alkaline fractionation technology and conversion of celluloserich bark residues into cellulose nanofibrils cnf 2 development of adhesive and coating formulations using bark polyphenols and cnf that meet technical requirements and build on safe and sustainable by design principles set out by the jrc and 3 combination of digital technologies in process design system dynamics modelling and data analysis to accelerate the adhesive and coating developments and evaluate technical socioeconomic and market opportunities the project findings will be disseminated to scientists policy makers society and industrial actors in relevant sectors including furniture construction transportation and packaging to raise awareness on the benefits of the adhesives and coatings developed from bark components the exploitation of results from superbark will have a measurable economic impact on the consortium companies and will also translate into clear environmental and health impacts to the society in alignment to the objectives set in the cbe ju annual work program
advancing greencare in europe an integrated multiscalar approach for the expansion of naturebased therapies to improve mental health equity

greenme aims to identify ways in which effective naturebased therapy and a broader green care framework can be scaledup to improve adult mental health and wellbeing equity while contributing to multiple socioecological cobenefits to that end over 4 years greenmes approach is to diagnose to increase scientific evidence on the mental health and wellbeing benefits of green care and to empower green care actors to finally increase the use of naturebased therapy and its integration within a multiscalar green care framework to ultimately promote just climate resilient and sustainable healthy communities greenme understands green care as a threescale continuum from natureineverydaylife eg the existence of green and blue infrastructure for viewing and walks to naturebased health promotion the promotion of active interaction with nature such as gardening and conservation to naturebased therapy the provision of treatment for individual patients we will use a transdisciplinary and mixedmethods approach to identify opportunities barriers causal pathways and patterns of inequitable distribution of mental health and wellbeing benefits from green care in study countries we will then cocreate solutions and guidelines including a eu framework and countryspecific schemes for bolstering green care along with an identified community of green care actors and design a training program for naturebased therapy providers informed by empirical evidence the evidence generated will offer replicable partnership models and guidelines to design impactful crosssectorial green care systems with national healthcare systems and local governments amongst the beneficiaries leading to a higher uptake of naturebased therapy and a general reframing of the green infrastructure functionality
eit health business plan 20232025

eit health is one of eight knowledge and innovation communities kics of the european institute of innovation and technology eit an eu body and institutionalised partnership under horizon europes pillar iii innovative europe eit healths vibrant community of more than 150 partner organisations from the worlds of business research and academia empowers a network of worldleading health innovators we bridge the gap between industry and academia to take on some of europes biggest health challenges promoting better health of citizens strengthening healthcare systems and contributing to a sustainable health economy eit health collaborates across disciplines borders and sectors reinforcing excellence creating knowledge and innovation and encouraging greater investment to deliver outcomes that matter most to citizens and patients in the eighth year since its inception eit health is consolidating its activities under a single unified structure the flagship the 20232025 flagships will tackle singleissue highly focused topics based on eu health priorities and will be the pathways to eit health reaching the impact set in its strategic agenda
a twophoton compound fiberscope to study the brain at all spatial and temporal scales

understanding how neuronal circuits process information is a major scientific challenge which demands new tools to address the complexity of the brain in animals during natural functioning twophoton 2p microscopy combined with optogenetics has revolutionized neuroscience thanks to the possibility to image and photostimulate neuronal activity with light but suffers from important limitations to determine how perception and behaviour arise we need to record and manipulate at will the activity of every neuron in a circuit in freely behaving animals 2p microscopy is on the contrary mainly performed in headfixed animals which poses a clear limitation to the study of natural behaviour at the same time understanding how different brain areas exchange information requires to maintain single cell spatial resolution 15 m and temporal resolutions compatible with the propagation of neuronal signals 1 ms over ultra large spatial scales 5 mm which is today completely out of reach for 2p microscopy in this project i will overcome these limitations and develop the 2p compound fiberscope a new optical technique based on the unique combination of multiple optical fibers and optimal spatial and temporal beam shaping approaches which will completely change the way we study neuronal circuits thanks to two main technologies 1 a flexible 2p microendoscope to image and photostimulate neurons in freely moving animals which will give access to entire brain regions with the highest imaging and manipulation efficiency and the fastest acquisition speed 2 the first 2p mesoscope specifically conceived to image and manipulate neuronal activity with single cell resolution across the majority of the mouse cortex on temporal scales compatible with the propagation of neuronal signals these technologies will pave the way for a real understanding of how neuronal circuits drive behaviour and how different brain regions communicate to process neuronal information
potassiumion electrochemical energy storage in metalorganic hybrid frameworks doped with redox and electron transport boosters

potassium ion batteries kibs offer unique opportunities for lowcost sustainable and highperformance electrochemical energy storage required for the electrification of transportation and for storing energy from renewable but intermittent resources however concerted efforts are required to tackle the challenges of kibs such as the short life low energy content and long charging time posidon will leverage the versatile material toolbox of metalorganic frameworks mofs and graphene derivatives core expertise of the applicant and host institution respectively to design and develop efficient electrode materials and introduce a paradigm shift in kibs performance posidon will build advanced hybrid kion batteries hykibs by engineering and studying 1 strategically designed cathodes based on coaxial metallicmof nanowires doped with redoxactive molecules to boost the conductivity and capacity and 2 sophisticated twodimensional anodes based on graphene derivatives with dense outofplane and inplane functionalities as hosts for single metal atoms acting as nucleation centers for the improvement of reversible deposition and stripping of potassium of potassiophilicity and impeding dendrite formation which is catastrophic for the lifecycle and safety these electrodes will dramatically improve the capacity the energy content of the hykibs and prolong their life moreover the high porosity of mofs and the conductivity of the envisioned electrode architectures will promote potassium diffusivity for fastcharging operation posidon will deliver practical cells of hykib devices with high performance to pave the way towards the commercialization of potassiumbased energy storage which is vital for a low carbon sustainable and fossilfuelindependent civilization
unravelling the dark universe from the canary islands observatories

astrophysical and cosmological observations imply that only 5 of the energy of the universe is made of conventional matter therest is composed by a new type of matter the socalled dark matter which has no or extremely weak interactions with the knownparticles and a yet more puzzling repulsive form of energy accelerating the universes expansion dark energy advancing ourknowledge on the nature of this dark universe is the focus of a global multidisciplinary effort in astroparticle physics indeed solving these puzzles have been identified as a priority for the future of particle physics and cosmology by several scientific agencies worldwide in this context undarks main objective is to transform the instituto de astrofsica de canarias iac into a worldclass institution in astroparticle physics this will be accomplished by leveraging iacs expertise in astronomy and astrophysics with the excellence and theoretical expertise provided by the worlds leading particle physics laboratory cern and three renowned eu institutions in astroparticle physics undarks work plan includes an ambitious program of networking scientific events staff exchanges and scientific collaborations that will significantly enhance the iacs research capacity and creativity and will increase its reputation within the eu and global ri systems this will be complemented by an extensive outreach program developed in parallel which aims to boost the recognition of the iac within the general public and public funding bodies finally undark also incorporates training activities focused on research management to increase the management capacity of the iac and its involvement in he funding programs in summary undark has been designed with the goal of achieving excellence at the widening coordinator in a priority area of fundamental physics research thereby addressing one of the most significant challenges in contemporary physics
a mistery of long secondary periods in pulsating red giants traces of exoplanets

exoplanetary science is one of the most studied and challenging areas of modern astrophysics various planet detection techniques allowed astronomers to discover over 4500 extrasolar planets in our galaxy providing important constraints for testing planet formation theorieshowever with the currently available methods it is still impossible to find planets in the far regions of the milky way and in other galaxies in consequence we still cannot answer fundamental questions of exoplanetary science such as how are planets distributed in our and other galaxies and how does their occurrence rate depend on the chemical content and density of their environments therefore it is urgent to find a new method of planet detection that will allow us to discover faraway planets and thus open new horizons for exoplanetary studies here i propose to develop such a method i will use a class of abundant bright giant stars that exhibit long secondary periods lsps as traces of extrasolar planets these stars are binary systems in which the companion is substellar and is submerged in a dusty cloud the hypothesis is that the companion is a former planet that accreted enough matter from the host star to become a brown dwarf i will use the high quality photometric and spectroscopic data of lsps from largescale surveys and combine them with modern hydrodynamical simulations to verify this hypothesisif successful the novel method will revolutionise the field of exoplanet detection by allowing to find extrasolar planetary systems beyond our neighbourhood and especially in other galaxies which is impossible with the current techniques in the next step i will apply this novel method to hundreds of thousands of lsp variables from the ogle catalogs of the milky way and the magellanic clouds to investigate the distribution of planets in different chemical and dynamical environments and thus provide completely new constraints for planet formation theories
mineye earth observation techniques for mine life cycle monitoring using mlbased data fusion approach

the mineye earth observation techniques for mine life cycle monitoring using mlbased data fusion approaches consortium consists of 13 partners from nine european countries and aims to strengthen eu autonomy in primary and secondary raw materials at the same time as reducing environmental impact this is done by development of innovative costeffective timeefficient and competitive earth observation eo based methodologies and technologies for the entire mining value chain mineye will integrate eo data with other data sources such as eurogeosource promine egdi and will collect new eo remote sensing geophysical and insitu data mineye aims at developing novel data fusion and processing algorithms for eo technologies for the mineral exploration operational closure and postclosure stages mineye unlocks the potential of eo data including copernicus commercial satellites upcoming hyperspectral missions airborne as well as in situ data this is achieved by creating generic innovative machine learning algorithms tailored to solve specific needs within the mining value chain mineyes overall objective and ambition is to increase the access to critical and strategic minerals and metals in europe with full consideration of environmental and social aspects by providing the mining industry with proven and validated solutions for uptake of eo data and technology mineyes final product is a webinterface ipop interfacing programming and optimisation platform for providing data and result ipop has three outputs each covering a specific part of the mining value chain 1 methods for mineral prospectivity mapping 2 eo plugin for liquidearth software for 3d modelling 3 evaluation and maps of remining potential and tailings characterization in addition ground stability assessment and environmental monitoring are included to support the development of a socially responsible mining ipop further serves as a multicriteria decisionmaking tool
toward democratization of evbased therapies

everzom has developed a patented fast costeffective largescale standardized extracellular vesicles ev production process to address the manufacturing issues that hamper ev translation towards clinic everzom has performed a successful platform scaleup to 6l meeting quantities needed for phase i trials placing it at least 2 years ahead of known competitorswith numerous european biotechs poised to enter clinical phase its timely to provide industrial players with ev largescale capabilities hence everzom intends to achieve key milestones during the next 2 years including the validation of platform gmp compliance at clinical phase i scale the scaleup toward latestage and commercial batch production as well as platform expansion usefulness towards different cell lines the acrobat project will enable us to be aligned with industrial players roadmap generate early revenues and achieve our ambition to be a european pioneer and leader in the ev manufacturing market