Dragon09/odtu_chatbot huggingface dataset:
nextgen wireless chip and antenna tech for wifi 8

pharrowtechs innovative project aims to revolutionize wireless communication by integrating millimeterwave mmwave technology into the future wifi 8 ecosystem leveraging expertise developed over 15 years at imec a global leader in nanoelectronics semiconductors and digital technology pharrowtech focuses on advancing chip and antenna technologies that promise to propel europe to the forefront of wireless communication this project envisions wifi 8 as a transformative force offering speeds up to 100 times faster than the stateoftheart and ensuring reliable highperformance connections by tapping into the mmwave spectrum offering 10x higher frequencies and 10x wider bandwidth pharrowtech addresses the spectrum shortage making connections more robust as data demands continue to increase in our digital worldthe proposed project prepares the ground for the integration of our mmwave technology into wifi 8 the work encompasses optimization of wireless system design refinement of critical components through rfic and analog block design enhancement of adaptability through digital processing and software development and realworld validation to overcome challenges like signal penetration and range limitationsthis undertaking positions pharrowtech as a key player in addressing the evolving needs of various industries including smart cities industry 40 healthcare arvr and beyond the successful execution of this project not only signifies technological leadership but also opens new markets enhances pharrowtechs competitive edge drives revenue growth and fosters strategic partnerships reinforcing the companys commitment to reshaping the wireless communication landscape it will also help strengthen the eus technological sovereignty in this key sector
lepton symmetry experiment matter antimatter symmetry test with electron and positron

in modern physics we are faced with the unsatisfactory situation that the standard model sm which condenses our current state of knowledge in the form of quantum field theories despite its spectacular success in the prediction of laboratory results fails in explaining even the most basic properties of our universe such as the disparity of matter and antimatter and the possible existence of dark matter in the quest to search for answers to these questions low energy high precision experiments in ion traps have taken a pivotal role by allowing precise tests of the charge parity and time cpt reversal symmetryi propose an ambitious nextgeneration penningtrap experiment that will enable us to directly compare the magnetic moments of electron and positron at 14 digits precision to this end we will simultaneously trap a single positron and an electron in the same trap and directly compare their spin precession frequencies to enable the cotrapping of the oppositely charged particle and antiparticle we will bind the electron in a hydrogenlike 4he ion as a result of the binding the spins of both particles show a slow beat which can be accurately measured any deviation of this beat frequency from the prediction by quantum electrodynamics qed reveals a cpt violation this way lsym will enable a uniquely sensitive comparison of particle and antiparticle charge mass and gfactors and thus yield the most stringent cpt test in the lepton sectorto this end we will develop a novel superconducting penning trap apparatus which can be cooled to millikelvin temperatures to largely eliminate blackbody radiation building upon techniques recently pioneered by my group lsym will allow the coherent quantum measurement of the difference of the spin precession frequenciesfurthermore with this toolbox at hand we will have access to a new class of intriguing measurements such as an order of magnitude improved determination of the electron atomic mass
myonanocell cardiomyogenic nanosized cellbased vehicles for cardiac microenvironment modulation and heart fibrosis therapy

cardiovascular diseases are the leading cause of death worldwide accounting roughly for 45 of all deaths in europe and costing billions of euros to the european union economy among these most cardiovascular diseases such as myocardial infarction lead to the formation of heart scarring which is the formation of fibrotic tissue that impairs contractility and cardiac function ultimately causing heart failure despite the prevalence and serious consequences of heart fibrosis current benchmark therapies have low longterm efficacy and alternative novel therapies that have reached clinical testing still present severe limitations or lead to little improvement in cardiac function thus there is still an urgent unmet need for the development of novel and efficient therapies for cardiac fibrosis cuttingedge research regarding the use of stem cells or delivery of molecules to induce cardiomyocyte proliferation are yet to be successful as most of these therapies present challenges regarding immunogenicity efficiency and longlasting effect thereby myonanocell project aims at developing a radically new platform for heart fibrosis and cardiac regeneration by using a combinatory approach where the myonanocell nanohybrids incorporate not only the ability to carry different cardiomyogenic molecules but also the ability to modulate the cardiac microenvironment and recognize cardiac fibroblasts myonanocell will radically increase therapeutic efficiency moreover the simultaneous modulation of cardiac microenvironment and its repopulation with cardiomyocytes by fibroblast reprogramming will directly impact contractility and heart function representing a paradigm shift in cardiac fibrosis therapy myonanocell will be fully characterized in vitro to have a full biological fingerprint on the process of cell identity shift and also tested in advanced 3d in vitro models to evaluate its overall effects at tissue level
cytosolic iron delivery for symbiotic nitrogen fixation

symbiotic nitrogen fixation snf carried out by legume nodules is one of the most efficient ways of introducing nitrogen in natural ecosystems and in sustainable agriculture it relies on the transfer of a relatively large amount of iron from the host plant to the endosymbiotic bacteria colonizing nodule cells where it will be used as cofactor of many of the enzymes participating in snf however the required steady iron supply for snf is challenged by its low bioavailability in soil prevalent in many of the main agricultural areas of the world this is worsened by the hundreds of ferroenzymes that compete for iron cofactors within a cell due to the relevance of snf for a more sustainable agriculture and the importance of ensuring iron supply to achieve this a substantial effort has been done in understanding how legumes incorporate iron and deliver it to the nodules and how it is used to synthesize nitrogenase cofactors however no information is available on how iron is specifically allocated to the nitrogenfixing compartments in this proposal we intend to study the mechanisms enabling targeted iron delivery to nitrogen fixation particularly those events occurring at the cytosol and at the interface between the two symbionts to do this we will identify and characterize the proteins interacting the known symbiosome iron transporters as a result we will characterize the ironinteractome of these elements these findings should not only increase our understanding of iron homeostasis in snf and more broadly in plants but also lead to dedicated iron delivery pathways for ironbiofortification or to engineer ironproteins in plants
exploring inflammasome activation and targeted inhibition

inflammasomes are cytosolic multiprotein complexes that form in response to a wide range of pathogens tissue damage and other harmful stimuli members of the family of nodlike receptors nlrs sense these pathogen and danger associated molecular patterns triggering innate immune responses nlrp3 is a wellstudied nlr whose activation by a broad spectrum of stimuli leads to inflammasome formation and pyroptosis yet the mechanisms inducing nlrp3 activation and the way how antagonistic small molecules counteract its function remain poorly understood just recently we have determined the cryoelectron microscopy structures of fulllength human nlrp3 in its inactive form and bound to the inhibitor crid3 native nlrp3 is a decamer composed of homodimers of intertwined lrr domains that assemble backtoback as pentamers we made the surprising finding that the effector pyrin domain is shielded inside the decamer cage providing a safeguard mechanism against accidental activation to obtain insights into the activation mechanism of nlrp3 and the molecular formation of the inflammasome i here propose a challenging and pioneering endeavour employing biochemical biophysical and structural analyses we will resolve the structure of activated nlrp3 associated to lipid membranes unravel its regulation by posttranslational modifications design specific inhibitors for the targeted protein degradation and explore filamentous seeds for the maturation of caspase1 and alzheimers disease forming amyloidbeta fibrils further transferring our knowledge of crid3mediated nlrp3 inhibition to other nlrs as nlrp12 and nlrp1 will shed light on their mechanism of action and open new avenues for directed targeting collectively this work will uncover fundamental molecular principles of inflammasome activation and the mode of action of antiinflammatory drugs i foresee that these insights will open a wide field for the development of nlrspecific inhibitors as new medicines
characterizing the neuronal effects of behavioralmodifying proteins from the zombie fungi ophiocordyceps using c elegans

ophiocordyceps unilateralis is a species complex of entomopathogens known for their ability to manipulate the behavior of infected ants zombie ants while these behavioral effects are well described the molecular basis for behavioral manipulation is still being explored during my current postdoctoral fellowship with the national science foundation usa i have identified a set of putative behavioral effectors and am currently utilizing the model organism yeast to express these biomolecules and test their behavioral effects in ants this proposal will build on my previous work by utilizing another model organism c elegans to analyze the transferability of these effectors to other animal models and to understand their effect on core neurological pathways to accomplish this goal i will collaborate with the van den heuvel lab at utrecht university a developmental biology team known for their excellence in the imaging of nematodes their access to a preestablished c elegans yeasttwohybrid library and experience with the genetic modification of nematodes will be paramount in addressing three research objectives set for this project identifying the biological targets of behaviormodifying effectors using yeasttwohybrid mating analyzing the behavioral effects of these effectors via transgenic expression in c elegans and evaluating tissuespecific changes at the molecular level in c elegans using mass spec such a project spans many biological subdisciplines and thus lends itself well to the international exchange of personnel advanced training and ideas allowing me to make use of my experience with molecular cloning and acquire new skills handling and observing c elegans furthermore the study of ophiocordyceps effectors present an innovative approach towards new drug discovery particularly those with the potential to treat behavioral disorders as fungal secondary metabolites are often used for medications impacting the public in a positive way
recreating a hero of modern science the making reception and legacy of the works of francis bacon

the monumental victorian edition of the works of francis bacon works appeared some 150 years ago in the midst of the second scientific revolution with the oxford francis bacon project yet to be completed it is still the standard edition of francis bacons 15611626 collected works the edition itself however has never been studied in any detail this is remarkable since by presenting the most uptodate baconian canon it played a key role in the creation of baconianism an outlook crucially formative of 19thcentury british science and philosophy a major intellectual event the works climaxed the emergence of serious bacon scholarship and propelled the search for a single scientific method shared across disciplines in the work of baconians like john herschel william whewell and john stuart mill at the same time it marked the start of a decadeslong process of revisionism which made that bacon eventually lost of his status as legislator of modern science and induction seized to be seen as the motor of scientific progress this project provides the firstever history of the making reception and extraordinary legacy of the works revealing its centrality to 19thcentury philosophical debates on science as well as its significance for 20th and 21stcentury bacon scholarship it will combine fresh archival research historical contextualization and philosophical analysis carried out at the worldleading department of philosophy and cultural heritage at ca foscari university of venice host and the department of history and philosophy of science cambridge secondment the projects original results will be disseminated through a monograph and peerreviewed articles and communicated through various targeted outreach activities it will enable the researcher to acquire significant new skills and expertise that will further strengthen his position as a leading scholar of the history of science and philosophy in the 19th century
sociallyacceptable and trustworthy humanrobot teaming for agile industries

manufacturing construction and agriculture are major driving forces for the european economy and prosperity maintaining its competitiveness in these sectors demands highly efficient and flexible processes and this can be achieved through digitization novel intelligent robotic capabilities that can be deployed sidebyside with humans and can operate and adapt to dynamic environments can accelerate this process however existing robotic systems cannot fit well into such settings as they are not versatile and flexible enough to automate certain tasks cannot collaborate safely with humans in open and dynamic environments nor are they easily and economically adaptable to process changes the soprano project coalesces multidisciplinary research and innovation in humanrobot collaboration and intelligent multiagent systems aspiring to design the next generation of manufacturing floors construction sites and agrifood production where humans and intelligent machines will seamlessly work together it proposes to scale collaboration from the single humanagent dyad to a peerbased synergy between multiple interconnected robotic systems featuring different physical and cognitive properties supporting various tasks in collaboration with human workers robotics and other agents soprano will validate the technological offering in three novel and openaccess use cases addressing both largescale industries and small to medium enterprises adding value to eu key sectors and instrumenting community building surrounding the opensource technologies in the eu industrial ecosystem during the project we will also enable external smes and startups to benefit from the project technologies via an open call which will enable the building of demonstrators using soprano technologies that will open new market opportunities for their products and services
mechanisms underlying functional disabilities in chronic musculoskeletal pain the role of protective factors

chronic musculoskeletal pain is a major health issue which translates into a severe economic burden studies on chronic pain conditions have focused primarily on characterizing pain mechanisms with a focus on alleviating clinical pain intensity the success of these studies in terms of effective treatment remains extremely limited rather than focusing on pain intensity protect will focus on functional disabilities associated with chronic musculoskeletal pain which are the main complain of patients they can be extremely debilitating and often result in social isolation of persons with chronic musculoskeletal pain to date their mechanisms remain poorly understood a better understanding of these mechanisms is essential to improve treatment efficiency in work package wp 1 of protect the impact of athletic identity and mental and physical fatigue on the relationship between resilience and functional disabilities will be studied in adults and minors with chronic musculoskeletal pain ro1 resilience is associated with functional disabilities athletic identity and fatigue a frequent comorbidity of chronic musculoskeletal pain characterizing the complex relationship between these factors using computational modeling will define new treatment targets that can be addressed by adapting already available therapeutical interventions all factors will be assessed using questionnaires as well as physical and behavioral tasks in wp2 restingstate fmri will be used to assess brain networks of functional disabilities in adults with chronic musculoskeletal pain in particular the role of the default mode network dmn in functional disabilities will be investigated ro2 changes in dmn connectivity have been associated with acute and chronic pain as well as with resilience and athletic identity finally protect will focus on the potentially mediating role of resilience and athletic identity on the relationship between the dmn and functional disabilities ro3
new value landscapes for plant protein pathways

the current european plantprotein landscape is flawed heightened societal awareness of the environmental impact of consuming animalbased protein is driving the publics awareness of alternative sustainable sources of dietary protein yet production systems are focussed heavily on the production of feedstock for direct transfer into animal sectors in an attempt to counter the eus overdependency on imported feed in essence there is an absence of premium supply chains farmers miss out on addedvalue opportunities that exist within the crops they already grow across europe there is a need to increase resilience in farming systems to mitigate against increasingly volatile climate patterns and to support farming systems to meet farmtofork strategic objectives built on the principles of cocreation innovation and demonstration valpro path will design validate and deliver sustainable and competitive plant protein crop systems and value chains focussed on underpinning economic value for all actors in the supply chain it will exploit beyond stateoftheart innovations demonstrating and evaluating potential across 5 multistakeholder living lab innovation production systems ipss with strong industry involvement the project will deliver a stronger ecosystem for plant protein production supported with robust evidence of the social economic environmental climate and health benefits valpro path will deliver new sustainable business models showing how focussed research can come into practice sustainable diversification of rotations with grain legumes will support the transition to more environmentally sustainable farming european agriculture is at a juncture in regards to the sustainable provision of dietary protein it can embrace opportunities presented through existing innovations that are integrated into reallife scenarios to support stakeholders realise the new market opportunities that exist for indigenous fully traceable plant protein
next generation datadriven reference european models and methods towards silent and green aircraft operations around airports

needed responds to the second and third bullets of the expected outcome of the horizoncl52022d50112 topic delivering the next generation datadriven reference european models and methods to estimate present and future aircraft emissions pollutants and noise achieving trl 4 at the end of the project to do so needed will advance the state of the art byimproving the accuracy of the reconstruction of aircraft operations by using realworld adsb dataadvancing emission inventories for current and future aircraft technologies while delivering more accurate pollution dispersion modelsextending the applicability of the ecac doc 29 noise model towards future aircraft technologiesperforming more accurate estimation of the number of people affected by local air transport operations by using dynamic population mapsthese activities are complemented by i local air quality laq and experimental noise measurements performed at rotterdam airport ii validation of the needed toolchain in a 30week pilot study involving three airports and iii delivery of a methodology to optimise the flight patterns for minimum detrimental impact on the population in present and future scenarios the project aims to function as a technology enabler laying the methodological groundwork for facilitating the entry into service of transformative aircraft technologies while capitalising on the potential of adsb data needed ensures its impact on the next generation of air traffic management atm regulation and policies through the direct involvement of eurocontrol
electrically pumped perovskite lasers

electrically pumped lasers are considered as a holy grail in the field of optoelectronics despite the success of lasers based on expensive epitaxially grown semiconductors lowcost solutionprocessed semiconductors provide new opportunities to significantly expand the applications of lasers on one hand lowcost and scalable deposition can meet increasing demand of using lasers in consumer electronics on the other hand solutionprocessed semiconductors can be easily proceeded into thin films providing great promise to develop thinfilm lasers which are required for highly integrated photonics chips in advanced applications a superstar in the family of solutionprocessed semiconductors is metal halide perovskites which have shown great success in a range of optoelectronic applications especially recent breakthroughs on optically pumped perovskite lasers and highperformance perovskite lightemitting diodes indicate great potential of developing perovskites into a new generation of materials for electrically pumped lasersthis project has the ambitious goal to realise solutionprocessed electrically pumped perovskite lasers i will take a holistic approach where novel concepts are proposed to address critical challenges on the development of perovskite lasers both typei and typeii perovskite quantum well heterostructures which utilise fundamentally different mechanisms to reach low thresholds will be developed as the gain media edgeemitting devices based on these new perovskite gain media will then be coupled into rationally designed cavities for lasing actions at the core of the research is the synthesis of new perovskite materials combined with advanced spectroscopic characterizations and devicecavity development this project makes use of recent advances in perovskite optoelectronics to create a new paradigm for electrically pumped perovskite lasers and will open up new possibilities to revolutionize the current laser technology