Dragon09/odtu_chatbot huggingface dataset:
first insight into endolysin mediated lysis in the wine microbiota

grapes are the largest fruit crop worldwide and in 2023 159 billion litres of wine was produced in the european union alone many challenges exist in the process of converting grapes into wine including those associated with the resident wine microbiota this microbiota consists of several microorganisms including oenococcus oeni and a variety of other lactic acid bacteria some members such as o oeni contribute mainly positively to the final product however there are certain species that are responsible for organoleptic defects therefore protection measures are in place to target spoiling bacteria of which the use of sulphites is one of the most common tactics as reduction of chemical preservatives is a relevant theme in recent years the search for alternatives is ongoing microbialbased alternatives are increasingly attractive and meet the demands for chemicalfree food products one such promising alternative involves the use of endolysins which are phageencoded hydrolytic enzymes used by phages to degrade the peptidoglycan layer of the host bacterium at the end of their lytic replication cycle endowine will strive to exploit phagederived endolysins as antimicrobials in wine with rapid activity and high specificity among the many reasons endolysins are particularly promising very few experiments using endolysins in food products have been performed but their potential has already been demonstrated in the medical and veterinary setting furthermore egg white lysozyme is already applied by the wine industryusing a multidisciplinary approach we will first determine the diversity of endolysins in phages infecting wine lab through in silico analysis candidate endolysins will be chosen cloned overexpressed and purified in escherichia coli after which their enzymatic activities and their antimicrobial spectra will be determined finally their impact on wine will be examined in small and large scale fermentation experiments
at the margins of equality a theory of vulnerability to social exclusion

the covid19 pandemic has exposed our shared vulnerability to isolation serving as a reminder that relations of marginalization and exclusion constitute significant obstacles to the achievement of a society in which everyone can fully participate and stand in relations of equality with each other moreover empirical research has shown that marginalised individuals are being disproportionately disadvantaged by the coronavirus emergency in several ways they are the target of stigmatization and discrimination and although they are more likely to experience mental health issues and are typically exposed to serious health risks they are not provided access to the same degree of medical care as other members of society the current sociopolitical state of affairs then vividly illustrates how persons vulnerability to social exclusion is one of the most pressing social justice challenges that liberal democracies must face building on my previous research on the justification and the value of equality in this project i will contribute to the horizon europe strategic plan towards creating a more resilient inclusive and democratic european society by developing the firstever comprehensive liberal egalitarian theory of vulnerability to social exclusion in analytical political philosophy this theory will define the rights that marginalized individuals have to be fully included as equals in society and identify the social arrangements that the state ought to put in place in order to ameliorate their social condition in our current pluralist and diverse societies the call for social equality is ubiquitous but its precise meaning is contested by providing an account of what shape equality takes when applied to socially marginalized groups this research will thus fill an important theoretical and normative gap when thinking about what a just society owes to its most vulnerable members if they are to be considered and treated as equals
mxenes as thermal catalysts exploiting the ideal properties of chameleonic materials

mxenes were discovered in 2011 and since then have attracted attention as electro and photocatalysts in contrast the ideal properties of mxenes as thermal catalysts remain almost unexplored there being a very limited number of studies the main reasons for this apparent lack of interest are i the shift in catalysis from heat as energy to overcome activation barriers to green electricity or sunlight ii the limited number of commercial mxenes and iii the relative novelty of these materials however mxenes offer unique compositional range structural flexibility and material properties that can make them disruptive catalysts these properties include i prediction of the catalytic properties by dft calculations ii possibility of metal alloying resulting in multimetallic mxenes iii absence or presence of surface terminal groups of various elements including oh o and halides iv control of lateral size from 2d to 0d forming mxene dots v strong metal support interaction making possible single atom catalysis the aim of discovery is fill the current gap applying mxenes to reactions in which their structure appears to be optimal according to the nature of active sites tioh or vo and dft predictions strong co2 adsorption on surfacefree mxenes specifically discovery will study two reaction types characteristic of some active sites such as titanol alkene epoxidation and vanadyl ch4 oxidation to ch3oh and oxidative alkane dehydrogenation or of metal nanoparticles hydrogenation of co2 and n2 and ch4 decomposition to h2 and carbon discovery will not be a trial and error check of new catalysts since it will be led be predictive dft calculations and artificial intelligence tools extensive use of xas to monitor the changes in the metal elements during the reaction and vibrational spectroscopy detection of reaction intermediates will shed light on the reaction mechanism
cracking the synaptic memory code

despite their role in longterm information storage synapses are highly dynamic and composed of rather shortlived components in the adult mouse brain it takes a couple of days for half dendritic spines to be replaced similarly at the molecular level most synaptic proteins have halflives in the order of a week meaning they constantly need to be replaced by freshly produced ones thus understanding how longterm memory can arise from unstable elements is one of todays neurosciences greatest challenges overturning an old dogma i discovered using in vivo and in vitro approaches that most synapses produce their own proteins locally at both the pre and postsynaptic sites interestingly classic plasticity paradigms produce unique patterns of rapid pre andor postsynaptic translation this finding is driving a paradigm shift in our understanding of synaptic function it is now possible to decode pre and postsynaptic memory traces formed during learningi am now in the unique position to combine omics cytometry superresolution and liveimaging techniques and behavioral learning tasks to unravel how local production of new proteins contributes to information storage at synapses firstly using liveimaging i want to understand how and when protein synthesis is recruited in excitatory boutons secondly using next generation sequencing and imaging i will investigate how mrna find their way to presynapses finally using a genetically encoded neuronal activation tracker i will follow the molecular changes and thus uncover the synaptic memory traces in the hippocampus and cortex after learning altogether these experiments will tackle from molecules to neural networks the unresolved question of memory encoding in the brain with an unprecedented resolution we will gain critical insights into how memories are stored at synapses such a fundamental understanding of brain function is needed to provide new avenues against neurodegenerative diseases
promoting ocean and water literacy in school communities

probleu will expand and support the network of european blue schools attract a wide diversity of new members improve ocean and water literacy across school communities and contribute to the objectives of the mission in particular 1 to protect marine and freshwater ecosystems and biodiversity and 2 to prevent and eliminate pollution probleu recognises that a significant change in environmental education is needed to foster broad societal responsibility towards oceans and waters and to encourage related behavioural change probleu will develop and offer a pool of innovative practical resources based on methodologies of open schooling besides several actions to promote encourage participation in and increase the diversity of the network two resources currently lacking from the majority of school curricula are explored in probleu 1 those related to what is collectively known as citizen science with work undertaken by educators together with communities to advance science foster a broad scientific mentality or encourage democratic engagement which allows society to deal rationally with complex modern problems and 2 the interaction with scientists in the field collecting and analysing data through citizen science ensures that student activities contribute directly to fostering their ocean and water literacy students engaging with the work of scientists eg through direct interaction or following the work on ocean research cruises have shown improvements in learning in the past but this opportunity tends to be limited to relatively few or privileged schools these resources will be complemented by stimulating the connection between people and the places where they live by fostering relationships between the school communities and their local waters probleu will assist schools in developing project activities related to the mission
reversible soecsoefc system for a zero emissions network energy system

the goal of 247 zen is to design and build a high performing 33100kw scale rsoc power balancing plant and demonstrate its compatibility with the electricity and gas grids the multidisciplinary consortium behind this project has been spearheading innovations in the energy management and are pioneers on the rsoc systems development together they cover every step of the value chain from enhanced materials on the cell level polito forth irec fully operational rsoc system spch spit ost fully integrated plug and play ecosystem for grid interconnection iner bos certh renewable energy generation eunice transmission system operator desfa and international quality assurance kiwa the ecosystems ability to optimize efficient routes of power to gas to power using h2 or ng as fuel and inject h2 into the grid transition in 30 minutes and round trip efficiency of 45 will be demonstrated while ensuring compliance with standards and safety regulations finally the consortium count on wellconnected organizations in the european hydrogen electricity and grid services sector hslu clube that ensures the dissemination of the developed new business models and practices for renewable energy storage including new concepts for the delivery of green hydrogen this consortium will develop and validate an ecosystem that can be efficiently scaled and replicated to multimw scale installations further knowledge on how to improve the performance of rsoc degradation rates of 04kh for 1000h current densities of 15acm2 in both modes and make them more cost competitive by reducing capex from 6000kw to 3500kw will be generated at the end of the project new and viable scenarios to provide grid balancing and supply green hydrogen will be presented by means of a deep technoeconomic analysis by advancing rsoc towards commercial exploitation the renewable hydrogen deployment required for a climate neutral europe will be one step closer
the neural underpinnings of childhood adversity

experiences of childhood adversity are major risk factors for subsequent vulnerability to psychopathology although research suggests that specific brain regions are particularly sensitive to childhood adversity the mechanisms that underlie these associations are yet to be elucidated and it is unclear how widespread connectivity networks contribute to this vulnerability phenotype this project aims to determine the functional connectivity networks in the brain that bare the signatures of negative experiences and the neuroendocrine mechanisms that facilitate such alterations to achieve this we propose two studies utilizing data from the uk biobank study 1 will investigate the resting state networks associated with early adversity this study will benefit from the statistical advantages of big data it will be the first analysis of this magnitude looking at the interplay between early life events and neural networks study 2 will characterize the interindividual variations in adversityrelated functional changes by addressing the moderating effects of glucocorticoidrelated genetic variants that increase biological vulnerability this study will contribute innovatively to the stateoftheart in the emerging field of imaging genetics this research uses advanced statistical strategies for neuroimaging analysis of an unprecedented number of scans and use of innovative analysis infrastructures under the fair principles furthermore it is strongly multidisciplinary involving a combination of psychological theory neuropsychology neuroimaging machine learning and genetics this action will involve endusers in all implementation stages with the aim to engage the public in science education raise awareness of stressrelated consequences and the need for widespread access to mental health care the proposal encompasses knowledge transfer to the host institution as well as extensive handson training for the candidate supported by the expertise of the host
controllable magnetic cores for transformers and electrical machines

ferromagnetic cores are used in transformers and electrical machines to allow producing a large magnetic flux with a small electric current these cores have been traditionally designed for guiding a predefined magnetic flux to a predefined location leaving them uninvolved with the actual control of the energy conversion process as the consequence there are millions of power and distribution transformers and variablespeed electrical motors in the eu alone whose performance compactness and robustness are limited due to need of complex mechanical arrangements or excessive current and voltage requirementssmartmag will advance the transition towards active and smart magnetics where the magnetic cores themselves take a key role in controlling the magnitude and distribution of magnetic fields in transformers and electrical machines starting from the fundamental principles of varying the reluctance of ferromagnetic flux paths by direct current biasing and voltagecontrolled magnetoelectric composites we will demonstrate unprecedented methods for tuning threephase transformers and synchronous motors during the operation significantly improving their performance and simplifying their construction compared to existing solutions we have identified four scientifically novel and industrially relevant target applications two transformers and two electrical machines whose conceptualization design manufacturing and validation form the overarching goal of the project our three objectives aim to push the relevant nonlinear and multiphysics material models beyond the stateoftheart implement them in customized numerical design tools for transformers and electrical machines and to validate the feasibility of the four concepts by working prototypes in laboratory conditionsas the result new methods will arise for reducing outdated auxiliary devices and enabling new functionalities in power delivery as well as designing improved motors for electric drives
building resilient innovations in democracy governance and excellence

the bridge project aims to boost the innovation capacity of the kyiv school of economics kse ukraine with particular attention to researchtopolicy transfer over a pressing policy problem the role of decision support and deliberative formats for citizen participation citizen assembly in the reconstruction of housing and infrastructures destroyed by the russian war against ukraine the project fills broader gaps in public administration theories and practice on how to blend representative and participatory models of democracy during crisis situations to achieve efficient and legitimate policy outcomes in democracies to achieve this goal kse has partnered with three excellent institutions erasmus university rotterdam eur the netherlands berlin university of technology tu berlin germany and university of tartu utartu estonia partners bring complementary expertise in developing and studying digital democratic innovations such as citizen assemblies and using public governance approaches to research and improve the adoption and diffusion of digital innovations hackathons site visits peertopeer mentoring online workshops and secondments serve to unleash the kyiv school of economics potential in three capacity domains i contribution to ongoing methodological and empiricalanalytical debates in the academic literature ii bridging the knowledge gap with policymakers and professionals and iii organisational capacity to sustainably secure grants and research funds for kses ongoing organisational development talent acquisition and preventing brain drain for maximum effectiveness kse will apply acquired knowledge to a pilot study of digital recovery system dream and its participatory module edem including a design and assessment of a pilot digital citizen assembly on a municipal level
a study of egyptian animal mummy styles

the seams project aims to investigate the wrapping weaves of votive animal mummies a religious phenomenon which was widely spread throughout egypt between the third intermediate period and the roman period 1069 bce380 ce ca seams is set to fill the gap in current knowledge on the contextual data of votive animal mummies and shed light on their manufacture through an innovative multidisciplinary and interdisciplinary methodology that integrates traditional research approaches with new technologies this study has never been undertaken before since egyptologists have long paid relatively little attention to these artefacts the project will contribute to the advancement of this field by reconstructing the original integrity of the wrapping patterns of specimens held in international museums through photogrammetry msi techniques and virtual restoration the multiscalar and cross analysis of the restored 3d replicas and their related data allows the recurring patterns to be identified and grouped into typologies the stylistic assessment of recurring wrapping weaves combined with further information from archives fieldwork and ctscans enables their occurrence within a specific period andor site to be recorded and any potential meanings unravelled textile and experimental archaeology protocols are set to provide an understanding of how the bandages were held in tension what the interweaving stages were and which tools were used furthermore a comprehensive account of the quality and quantity of the resources technologies and efforts employed permits an evaluation of the economic weight of the wrapping procedures the research outcomes are to be widely shared through open science practices outreach activities a free and open access visual repository and a temporary exhibition on votive animal mummies that will contribute towards generating knowledge about these longneglected artefacts
highly efficient and lowimpact innovative thermal storage system for enhanced dispatchability in concentrated solar tower plants

heliotrope is a groundbreaking research and development endeavor dedicated to advancing concentrated solar power csp technology to unprecedented heights this project focuses on developing stateoftheart molten salts and materials technologies for thermal energy storage systems pushing the boundaries of operational temperatures beyond the current industry standard of 600c a holistic approach is at the heart of heliotropes mission sustainable novel molten salts as thermal energy storage mediums and the remarkable ability to withstand absorber surface temperatures of up to 850c are introduced promising to enhance csp plant efficiency and dispatchability this technological advancement aims to redefine the capabilities of csp plants furthermore heliotrope aligns closely with key european energy policies and initiatives contributing significantly to energy security reducing reliance on fossil fuels and lowering greenhouse gas emissions the project supports the vision outlined in the european green deal clean energy for all europeans and the fit for 55 legislations fostering sustainability and competitiveness in the energy sector heliotrope aspires to reshape the csp plant landscape making them not only more efficient but also inherently environmentally friendly the project represents a significant stride towards a sustainable energy future where csp technology leads the way in innovation and progress redefining the boundaries of what is possible in the pursuit of a cleaner more sustainable energy world
fdsoi pilot line for applications with embedded nonvolatile memories rf 3d integration and pmic to ensure european sovereignty

the fames pilot line consortium led by cealeti is composed of 4 hosting sites cealeti tyndall vtt and sal consortium also includes rtos such as imec fraunhofer cezamat wut universities with uc louvain grenoble inp and universidad of granada and the association sinanowith the goal of transferring results to the eu semiconductor industry the fames pilot line will develop advanced technologies offering 2 generations of fdsoi at 10nm and 7nm nodes addressing the surging demand for fdsoi technology this fdsoi platform will be enhanced with integrated nonvolatile memory radiofrequency components 3d options and magnetic inductances to improve power management these advancements will facilitate the development of innovative chip designs offering significant performance improvements and efficiency gains this will lead to nextgeneration products including microcontrollers mpus 5g6g chips imagers sensors secure chips quantum chips and edge ai chipsthe fames pilot line will offer users an open access framework for rd services and prototyping access will be available through two mechanism a reactive one that will entail the consortium to evaluate the feasibility of users spontaneous requests and a proactive one featuring an annual open call forty industry leaders including nokia ericsson infineon bosch and stmicroelectronics have pledged their support through signed letters intending to leverage the fames pilot line capacity for technology evaluation and integration into their productslinked to the design platform and competence centers the fames pilot line will establish a worldclass environment dedicated to skill enhancement through specialized training and summer schools it will champion sustainable practices within cleanrooms and process development with its expertise and knowledge the consortium is poised to effectively launch the fames pilot line and will transfer results to industry