Dragon09/odtu_chatbot huggingface dataset:
analytical approaches for the assessment of human exposure to polyhalogenated alkanes pxas

chlorinated paraffins cps are polychlorinated linear chain alkanes with high production volumes used as flame retardants and plasticizers in a wide array of consumer goods cps may be released from treated goods and have become widely distributed in the environment and human tissues humans are exposed to cps via contaminated indoor dust and food while certain cps have been registered as united nations persistent organic pollutants pops and their usage restricted due to well documented toxic and bioaccumulative properties recent evidence has suggested that banned cps may have been replaced by compounds known as polyhalogenated alkanes pxas which share very similar chemical structures to cps differing only by the addition of bromine atoms both cps and pxas comprise of mixtures of thousands of isomers making analysis and quantification highly complicated a recent pilot study of pxas in indoor dust revealed that the replacement compounds may be present at similar levels as banned cp groups based on the physicochemical similarities pxas are predicted to share similar bioaccumulative and toxic properties as banned cps but have not been studied widely this research projects aims to develop the first analytical procedures for quantification of pxas in indoor dust and generate methods for assessing the occurance of pxas in a variety of environmental matrices measurements in indoor dust samples from europe and the united states of america will be used to conduct a worldfirst human exposure assessment for pxas developed methods will then be applied for retrospective screening of pxas in archived data files to provide a broad snapshot of pxa contamination in food and the environment for the first time the outcomes of this project are intended to characterize the current contamination status of pxas in indoor dust food and the environement with the objective of public health protection against potentially hazardous chemicals
pep4lep 20 chemoprohylaxis for leprosy comparing the effectiveness and feasibility of a communitybased intervention to a health centrebased intervention in ethiopia mozambique and tanzania

background leprosy is a significant public health problem early detection treatment and prevention are crucial to reduce transmission and disabilities the world health organization who recommends singledose rifampicin postexposure prophylaxis sdrpep for screened contacts of leprosy patients the pep4lep 20 study builds upon the edctp2pep4lep project to identify the most effective intervention to screen individuals for leprosy other skin neglected infectious diseases skinnids and common skin diseases and to provide sdrpep the study takes place in leprosy highendemic areas in ethiopia tanzania and mozambique it determines which intervention has most effect on leprosy case finding and detection delay however the covid19 pandemic hampered the initial pep4lep study through delayed interventions and medication shortages affecting the main outcome indicator case detection delay methods pep4lep 20 is a twoarm clusterrandomized implementation trial to compare two interventions 1 a communitybased skin camp intervention screening 100 leprosy patients community contacts for leprosy and other skin diseases and administering sdrpep and 2 a health centrebased screening intervention inviting leprosy patients household contacts to health centres for screening and sdrpep to ensure a scientific sound analysis pep4lep 20 collects additional data increasing the sample size by 25 to understand the pandemics effects and enable analysis with and without covid19 influences skin camp organization skinnid distribution health staff capacity and acceptability will also be studied results will be modelled to assess the longterm impact related to costs impact pep4lep 20 results will reflect scientific societal and economic impact towards reduced leprosy transmission they will be disseminated to all stakeholders scientists policymakers who health staff affected communities ngos and the general public in the eu and africa
reconciling citizens with the tradeoffs of democracy attitudes toward democracy under rising politicization

democracies involve tradeoffs since all their desirable qualities cannot be simultaneously maximized hard choices must be made in order to balance democratic principles such as popular sovereignty and the rule of law or freedom and political equalitythese tradeoffs would not be problematic as long as citizens and political leaders were open to compromise and accept that democracy requires a delicate balancing of virtues the politicization of these tradeoffs in recent events such as brexit or polands judicial reform suggests that this is likely not the case however we still know very little about the positions of citizens and parties regarding democratic tradeoffs how these contribute to citizens increasing discontent with democracy how the rising politicization of the tradeoffs of democracy might exacerbate these dynamics and whether it is possible to curb this processto investigate these questions this project 1 elaborates a conceptual map of democratic tradeoffs and empirically examines citizens preferences and parties positions on them 2 analyzes the determinants of citizens democratic tradeoff preferences and how the interplay between these preferences and parties politicization of these tradeoffs affects individuals support and satisfaction with democracy 3 examines how citizens can be reconciled with the idea that some democratic qualities cannot be simultaneously maximized the empirical analysis focuses on 15 european countries and implements an integrative multimethod approach combining crosssectional and panel surveys content analysis and experimentsthe proposed project breaks new theoretical and methodological ground in the study of political culture it brings the inherent tensions of democracy to the forefront and develops new tools for the measurement of tradeoff preferences and their consequences
machine learning in science and society a dangerous toy

deep learning dl models are encroaching on nearly all our knowledge institutions ever more scientific fieldsfrom medical science to fundamental physicsare turning to dl to solve longstanding problems or make new discoveries at the same time dl is used across society to inform and provide knowledge we urgently need to evaluate the potentials and dangers of adopting dl for epistemic purposes across science and society this project uncovers the epistemic strengths and limits of dl models that are becoming the single most way we are structuring all our knowledge and it does so by starting with an innovative hypothesis that dl models are toy models a toy model is a type of highly idealized model that greatly distorts the gritty details of the real world every scientific domain has their own toy models that are used to play around with different features gaining insight into complex phenomena conceptualizing dl models as toy models exposes the epistemic benefits of dl but also the enormous risk of overreliance since toy models are so divorced from the real world how do we know they are not leading us astray toy addresses this fundamental issue toy 1 identifies interlocking model puzzles that face dl models and toy models alike 2 develops a theory of dl toy models in science and society based on the function of their idealizations and 3 develops a philosophical theory for evaluating the epistemic value of dl toy models across science and society in so doing toy solves existing problems answers open questions and identifies new challenges in philosophy of science on the nature and epistemic value of idealization and toy models
development of chemical looping gasification of microalgae for the 3rdgeneration biofuels production

global warming is leading to serious climate consequences worrying the world whats worse the global co2 budget will be used up soon likely before 2030 therefore actions for co2 mitigation are urgently needed to meet the agreed climate targets negative emissions technologies nets are possibly the only implementable option to tackle this problem in such short period this project stands on a novel nets technology called chemical looping gasification clg and aims at producing the 3rdgeneration biofuels g3biof clg is an unmixed gasification using oxygen carrier to transfer oxygen for gasification thus fuel and air never mix in light of this unique feature the gasification product is absent of n2 dilution thus the co2 capture is inherent and in the ashfree air reactor heatexchanger corrosion is less possible microalgae is biomass a major source for g3biof but it has very high content of problematic ash impurities however clg is hypothesized capable to handle this fuel in addition to its negative co2 emissions this project will first select suitable oxygen carrier for microalgaeclg through intensive experiments in a batch fluidizedbed reactor and an 15 kw continuous pilot the selected oxygen carrier will be used in a 50 kw dual fluidizedbed pilot for proof of concept and performance optimization a process model with reaction kinetics details will be established and used to analyze the technology integration with downstream processes finally life cycle assessment lca will be applied to the process chain to evaluate the environmental impacts this is expected to identify the most promising integration having the best economic and lowest environmental impact through the project the applicant will progress as a scientist and gain at least skills of lca complex pilot operation tar analysis this project is ambitious for a much greener production of biofuels and the results are important to power a sustainable future
cyclic nucleotides as second messengers in plants

multicellularity in plants and animals arose independently as reflected in dramatically different signalling mechanism makeups intracellular signallings central paradigm in animals is the concept of second messengers most prominently camp and cgmp contrastingly in plants campcgmp are not part of mainstream ideas on signallingour recent unexpected identification of camp and cgmp acting in the canonical signalling for the phytohormone auxin inspired a paradigmshifting hypothesis that camp and cgmp act as largely unappreciated versatile second messengers in multiple plant signalling pathways this would dramatically expand the modes of plant intracellular signalling opening possibilities for additional regulations and crosstalks it would also provide a new means of targeted engineering of signalling outputs highly relevant for plant biotechnologyto systematically explore this radical hypothesis i propose to generate optogenetic tools to i monitor and ii specifically manipulate cellular campgmp levels our vrootchip microfluidics setup allows us to iii survey the plant signalling landscape and identify pathways involving campgmp further supported by iv identification of thusfar elusive campcgmp targets as a blueprint for the use of the generated tools and knowledge we plan v to elucidate the role of cgmp in phytohormone jasmonate signalling together these approaches will establish campcgmp as bona fide second messengers in plants we provide a rich resource to investigate their involvement in any chosen signalling mechanism or cellular response while offering tools to manipulate their signalling output for both fundamental discoveries and targeted applicationsthis strategy poses considerable intellectual and methodological challenges but our robust initial results including functionality of campcgmp sensors show a conceptual breakthrough is feasible dramatically expanding our current view on plant signalling and beyond
reusing effluents from agriculture to unlock the potential of microalgae

realm will transform nutrientrich drain waters from soilless farms into value by producing microalgae at reduced costs while treating water and capturing co2 from the air this concept will increase the circularity and profitability of microalgal production and soilless farming the nordaqua and algacycle projects nordforsk and eea respectively have shown the feasibility of this concept in finland and portugal and now realm aims to demonstrate it at an industrial scale accordingly two validation facilities will be installed in the netherlands and finland and two demonstration facilities will be deployed in portugal and spain near soilless greenhouses with knowhow from the sabana project h2020 these facilities will operate photobioreactors under a turbidostatic regime continuous harvest for maximum productivity using nutrientrich wastewaters from the greenhouses growth and harvesting units will be powered by photovoltaic energy and automatically managed by novel sensors while aibased predictive models and a cloudbased monitoring system will assist production microalgal biomass will be processed by local downstream processing units using dairy industry supply chain as a working model this concept will offer sustainable wastewater treatment technology to farmers by closing the nutrient loop and is expected to reduce microalgae production costs by 50 whose savings will be used to increase the competitiveness of the proposed microalgaebased products namely agrochemicals and aquafeed a business model will be developed to propose the installation of multiple microalgae production facilities next to soilless greenhouses and connected to a centralised processing facility the results generated by realm will be disseminated so the demonstrated concept can be replicated by relevant stakeholders in all eu while targeting several objectives established by the european green deal such as working with nature to improve human health by promoting a greener industry
the environmental exposome and health

envesome aims to elucidate mechanistically the role of air noise light and hazardous waste pollution in noncommunicable disease development the project addresses the need to strengthen the knowledge available to policymakers regarding pollutiondisease associations and causal mechanisms at different phases throughout the human lifecycle envesome proposes to develop an exposome and citizensciencebased framework for assessing the risks of emerging environmental health stressors this will be achieved by fusing environmental monitoring and personal exposure data and models through ai tools human and cell biology knowledge human biomonitoring and in vitro data will be used to determine adverse outcome pathways and networks associated with environmental stressors particular focus will be paid to intersecting pathways relevant to cardiorespiratory disease metabolic syndrome neurotoxicity immunotoxicity sleep and mental health disorders we aim to elucidate the main sources of environmental exposure and drivers of the adverse outcomes above this will allow for the articulation of costeffective mitigation strategies that will be applied in select case studies their efficacy will be evaluated using environmental and exposure indicators together with early effect biomarkers eeb methodological and technical innovations and the respective scientific evidence regarding the causal links between emerging environmental stressors and human health will be translated into policy proposals supporting the articulation of strategies for country or cityspecific targeted and costeffective interventions thus promoting effective public health protection as well as guidelines and updated limit values as needed environmental management for public health protection will be supported by a decision support system for policy makers a chatbot for health practitioners and a mobile app for citizens training on novel tools will be given to all relevant actors
graspos next generation research assessment to promote open science

graspos aims to build and operate a data infrastructure to support the policy reforms and pave the way towards a responsible research assessment system that embeds os practices and accelerates its adoption in europe graspos will focus on extending the eosc ecosystem with tools and services that will facilitate monitoring the use and uptake of various types of research services and outputs publications datasets software and will catalyse the implementation of policylevel rewards to foster os practices these tools and services will build upon multiple sources of metric data eg opencitations scholexplorer including capabilities offered by the eosc core that will be federated in the context of the project and will take into consideration both contemporary guidelines for responsible research assessment rra like those provided by initiatives like dora and the leiden manifesto and the suggestions from a diversity of relevant stakeholders graspos will also incorporate piloting activities to codesign showcase validate and evaluate grasposs key results considering domainspecific aspects and different levels of osaware rra such as the researcher individualgroup institution and national level
translating science into policy a multisectoral approach to adaptation and mitigation of adverse effects of vectorborne diseases environmental pollution and climate change on planetary health

planet4health provides new knowledge and tools on environment degradation and its impact on human animal and ecosystems health the project results will support policy making process and citizens awareness on sustainable planetary health climate and environmental policies and adaptation and mitigation strategies to natural hazards planet4health will develop collaborations from a large variety of organizations from the environmental and climate science public health epidemiology veterinary medicine social political and economic science engineering law and ethics and communication to produce solid knowledge and tools to facilitate learning and practice on the interaction between the natural system and human health four tailormade case studies will be performed 1 one health effects of vectorborne diseases 2 air pollution 3 food contamination arising from soil and water contamination 4 mental wellbeing linked to environmental and climate stressors in different geographical area thanks to the large project network that will draw universal conclusions and replicable solutions to improve the predictive capability and preparedness the consortium will produce research technological innovation tailored outreach and training and policy solutions through a crosssectorial multidisciplinary scientific collaboration in line with the transnational character of planetary health for these aims the project will a collect organize and assure open availability of new and already existing data on climate and environmental indicators linked to one health b carry out analyses on data and build innovative interoperable and multifunctional digital prototypes c produce new knowledge and tools to support one health policies by applying social science theories and involving citizens policymakers and stakeholders d offer openaccess data tools and research material to public authorities for decision making and academic research for further study
resilient multimodal freight transport network

remunet identifies and signals disruptive events and assesses their impact on multimodal transport corridors it reacts quickly and seamlessly upon disruptive events in realtime it supports tmsproviders to improve route planning resilience remunet communicates alternative predefined multimodal transport routes to logistics operators and subsequently to truck drivers locomotive drivers and barge captains through this it enables a faster and adaptive multimodal network response remunet orchestrates route utilization suggests transshipment points and optimizes capacity allocation minimizing damage and shortening the recovery time what is remunets core objectiveas trailblazer for the physical internet remunet pursues the vision to enable and incentivize synchromodal relaytransport on european rail road and inland waterways to increase the holistic network resilience it significantly reduces emissions and boosts freight transport corridor efficiency in case of disruptive events how will remunet achieve this1a standardized method to describe multimodal transport networks the proposed standard is derived from existing approaches and developed together with critical stakeholders to ensure europewide practicability and acceptance2an algorithm capable of calculating multimodal route alternatives and capacity utilization in the face of disruptive events it uses realtime data for dynamic synchromodal alternative route planning 3a collaborative platform connecting relevant freight operators and enables them to manage disruptions this is done by providing secure and resilient digital logistic and network management tools enabling alternative route planning information and orchestrating eventbased synchromodal relay transportation 4using reinforcement learning to model and evaluate alternative courses of action providing the basis for a selflearning adaptive multimodal european freight transport and logistics network
electrification of industrial processes using induction and microwaves technologies

joulia aims to develop two innovative electricheating processes to maximize their flexibility energy savings and res integration into two midtemperature manufacturing processes to this end induction and microwave technologies will be demonstrated in the rubber and plastic sector for rubber vulcanization rubber production and glue thermal activation multilayer pipes production respectively in this vein processes configuration will be optimised and monitored using the developed digital models and process simulations to finetune the whole industrial process enabling their control adaptability and cost optimization health and security requirements will be implemented supported by a predictive maintenance tool both contactless systems will be validated at trl7 including technical and economic studies tea and lcalcc using previously developed models additionally joulia solutions replicability potential will be assessed in other industrial sectors food and ceramics addressing future upscaling plans to be aligned with new market opportunities and stakeholder engagement general public awareness of electrified technologies will be improved while new business models and training materials will be developed joulia will contribute to decarbonizing a sector that heavily depends on fossil fuel combustion trying to maximize its energy efficiency sustainability and economic benefits improving european industries competitiveness and supporting their clean energy transition to achieve these objectives joulias consortium consists of 16 partners from 7 eu countries with diversified expertise and knowledge of the addressed processes and access to the required lab and pilot infrastructure at the end of the project joulia will increase the resilience and security of european industrial as well as minimize its dependence on imported fossil fuels