Dragon09/odtu_chatbot huggingface dataset:
the first ivdrapproved commercial software solutions for aipowered rnabased companion and precision cancer diagnostics of acute myeloid leukaemia and bladder cancer

qlucore is developing visualisationbased analytical solutions with an established position in the nextgeneration sequencing ngs market as pioneers in rnadata analysis we aim to revolutionise the field of companion and clinical diagnostics by developing software platforms integrating aipowered machinelearning classification models for gene expression signatures and gene fusion analysisby providing highly accurate and specific diagnoses our platform represents the future of precision oncology putting europe at the forefront of aipowered cancer classification a softwarebased setup speeds up the introduction of new clinical guidelines and companion diagnostic solutions with the ultimate purpose of increasing survival rates and overall health we aim to cover all cancer types relevant for gene expressionbased diagnostics and then scale up into noncancer indications eg cardiovascular and neurological diseases immunological disorders and other data types eg proteomics and singlecell rnaseq further disrupting the precision diagnostics industry currently we are preparing the solution with a classification model for bcell progenitor acute lymphoblastic leukaemia bcpall for the first ivdr certification proof of concept building on those achievements and leveraging regulatory and data management experience and progress in the proposed project we will focus on acute myeloid leukaemia aml and bladder cancer bc for aml and bc we will develop and cecertify classification models and companion diagnostics cdxspecific classification models the successful completion of this project will significantly improve europes position in genomics and aibased precision diagnostics and as such prompt similar initiatives across europe this will allow the eu to compete effectively with market leaders in particular the us and offer significant benefits to patients diagnosed with cancer and society as a whole
fostering local beautiful and sustainably designed regenerative textile and clothing ecosystems

the transition towards a more sustainable digital and inclusive economy in europe requires a humancentred approach that combines digital and industrial technologies and which has an eye for spatial dynamics however there is a lack of integration between different disciplines and initiatives resulting in missed opportunities for this transition fabrix aims to address this challenge by adopting an integrated approach to local and regenerative urban manufacturing combining spatial design developing opportunities for industrial symbiosis and circular manufacturing and by value chain analysis and management fabrix will develop an innovative and interactive platform mantel that supports local valuechain management for more circular and regenerative urban manufacturing fabrix focuses on the textile and clothing sector tc in athens greece and rotterdam the netherlands tc is one of the most environmentally and socially unsustainable sectors it is a priority in the european green deal the circular economy action plan and the industrial strategy the core innovation of fabrixs research design and implementation is the entanglement of spatial and relational perspectives perspectives that cannot be seen apart but that in practice are mostly dealt with separately in policy and research thus hampering significant progress fabrix allows for a proactive cocreated implementation and change of the observed suboptimal reality fabrixs focus on the tc sector its innovative mix of research methods its interactive opensource digital platform of tools and its capacitybuilding fabrix academy will ensure the transferability during and beyond the research and innovation action to other places and other sectors dealing with similar suboptimization
definable algebraic topology

this project addresses fundamental issues in the development of algebraic topology coarse geometry and other areas of mathematics related to the problem of doing algebra when the structures under considerations also have a topology a number of other approaches have been proposed recently showing the current importance of these issues for the mathematical community the approach followed in this project is unique in harnessing powerful tools from mathematical logic and especially descriptive set theorythe fundamental idea is to enrich an algebraic object with additional information provided by a polish cover which is an explicit presentation of the given object as a suitable quotient of a structure endowed with a compatible polish topology the goal of this project is to show that fundamental invariants from homological algebra algebraic topology operator algebras and coarse geometry such as ext cech cohomology kktheory and coarse khomology can be seen as functors to the category of groups with a polish cover furthermore doing so provides invariants that are finer richer and more rigid than the purely algebraic onesthese invariants will allow us to tackle classifications problems for topological spaces coarse spaces calgebras and maps that had been so far out of reach furthermore we will use these invariants to calibrate the complexity of such classification problems from the perspective of borel complexity theory in turn this will enable us to isolate complexitytheoretic consequences of the universal coefficient theorem for calgebras and of the coarse baumconnes conjecture for coarse spaces and to construct examples of strong failure of such results ultimately the completion of this project will lead to the development of entirely new fields of research at the interface between logic and other areas of mathematics algebraic topology coarse geometry operator algebras
mercenarism and the accountability void finding routes to accountability and remedy for the victims of human rights abuses perpetrated by mercenaries

the recent increasing use of mercenaries in armed conflicts such as in libya central african republic nagornokarabakh mali and ukraine has focused attention on some of the problems arising from the deployment of these private actors their involvement in proxy wars predatory recruitment and asymmetric warfare which internationalise exacerbate and prolong armed conflicts creates space for grave human rights abuses and war crimes millions of people are directly negatively impacted by mercenaries globally but accountability is rare and so these actors operate with impunity their victims denied access to justice and redress in essence mercenaries operate in an accountability void academic attention until now has focused on the antimercenary norm definitions of mercenary and treatment of mercenaries but there is little research on how accountability and remedy is ensured for victims of mercenarism mercury focuses on this accountability void combining cuttingedge datadriven mapping and analysis of mercenary operations with thorough legal and qualitative analysis the mapping will provide a novel understanding of mercenaries to underpin groundbreaking legal analysis of the shortcomings and weaknesses of national and international frameworks when it comes to remedies for victims via legal and qualitative analysis mercury will evaluate routes to accountability and remedy via international and national human rights courts tribunals mechanisms and transitional justice processes and propose potential pathways to justice for victims pi macleod is internationally recognised for her expertise on mercenaries and human rights together with the mercury team she will offer pioneering scholarly insights into routes to accountability and remedy the richer understanding derived from mercury will help inform stakeholders on how they can better prevent abuses perpetrated by mercenaries or failing that ensure accountability and redress for victims
stable 211atlabeled radiopharmaceuticals for targeted therapy

astatine at is the rarest naturally occurring astatine at is the rarest naturally occurring element on earth exhibiting only shortlived radioisotopes one of them 211at decays with a halflife of 72 h by emission of a highly energetic alpha particle making it one of the rare alpha emitters suitable for targeted alpha therapy tat of cancers if bound to an appropriate cancer targeting molecule because the number of cyclotrons able to produce it has seen a significant rise in the past years it is expected that 211at will become more accessible and play a major role in the development of tatastatine belongs to the halogen elements and despite more than 80 years since its discovery many chemical properties remain to be discovered this lack of knowledge is due to the absence of stable isotopes and the availability in minute amounts that preclude the use of standard analytical methods yet research has shown that at behaves similarly to metals but also to halogens forming bonds similar to its closest homologue iodine such as the carbonat bond this strategy is the main approach currently available to develop 211atlabeled radiopharmaceuticals yet a lack of in vivo stability of the cat bond is often observed resulting in the release of 211at before it reaches its target and leading to irradiation of healthy tissues improving this stability is therefore a major challenge that remains to be overcome in order to unleash the potential of 211at in cancer treatmentsin this context the objective of the satradio project is to explore alternative bonding modalities to the cat bond in order to develop novel radiolabeling approaches with improved in vivo stability the strategies developed will exploit both the halogen and the metallic character of at using analytical and computational approaches that have recently become available and making possible to elucidate the chemistry of this enigmatic elements at the trace concentration it is available
connecting pockets of metacity excellence around the baltic sea region

the main objective of metacities is to speed up consolidate align and leverage the existing metacity and smart city initiatives of the partner regions and through this build the worlds leading connected metacity region across the baltic sea bsrmetacity is a novel smart city and urban innovation concept focusing on open innovation which is supported and encouraged by digital environments and social networks metacity is responding to and leveraging on the postpandemic transition to virtual cooperation and virtual urban services metacity is an emerging regional policy objective already in regional policy planning in oulu region and latvia metacity aims to expand ictoriented smart city development to a wider base of regional innovation capabilities and innovation capture including for example service innovations and social innovationsthe metacities project connects a balanced mix of metacity and smart city ecosystems definite global thematic leaders thematic followers urban capital areas midsize central towns and more rural regions it will strengthen ecosystem collaboration between the metacity regions in the baltic sea area and prepare the collaboration opportunity space it will create a joint action plan for baltic sea metacity regions and decide the action plan details in interaction with regional funding decisionmaking metacities aims to position the eu bsr area as the worlds leading connected regional innovation valley for metacity innovations
green recycling route for smco permanent magnet swarf

permanent magnets pm have a wide range of applications and play an important role in the realization of a sustainable future with the increasing demand for green and renewable energy production and sustainability comes a rise in popularity and demand for electric vehicles ev and hybrid electric vehicles hev which use permanent magnetdriven electric motors however the development of technology and shrinking dimensions of parts used for such technologies has made postprocessing and machining of the bulk pms inevitable this in turn leads to a 30 waste of the magnetic material as swarfrejects pms are made of a combination of rare earth elements ree transition metals tm and some other elements the scarcity of the rees and volatile and unstable price of the tm market especially cobalt has pushed the eu to encourage scientists to come up with feasible methods to revive the mentioned waste and thus achieve a circular economy and guarantee sustainable energy production and by doing that help the eu to achieve its green deal initiative goal set for 2050 the recycling of samariumcobalt smco permanent magnets has been the target of a number of scientific studies however the proposed methods are all very energyintensive and require a lot of mineral acids and generate a huge amount of wastewater during the process in this proposal we suggest a green and facile method based on electrodeoxidation of the oxidized magnet swarf which will require much less energy consumption and will require a negligible amount of acids and chemicals compared to the conventional methods
reimaginecrops a realtime mobile multimodal positron emission tomography and multiphoton endoscopic technology for realistic infield quantitative imaging of crops

sustainable agriculture strategies have become central to european and global orientations as the demand of food increases with the rising world population current technologies qualitatively drive the application of nitrogen nfertilizers to stressed field areas but cannot precisely modulate the needed amount resulting in dangerous n dispersion ecological and economic losses reimaginecrops envisions applying basic plant science into crop management by quantitative infield measurements of biophysical processes occurring at tissue and cellular level the consortium will implement the first realtime infield portable multimodal multiscale positron emission tomography petmultiphoton endoscope me technology pet measures the metabolic processes in the crops at the scale of hundreds of micrometers while guiding the me system to visualize functional mechanisms at a cellular level the aim is to tailor the amount of fertilizer to be used by enabling measurement of functional processes reflecting the local and systemic crop signal pathways triggered by nfertilizer shortly after applicationreimaginecrops involves realtime pet reconstruction hydrodynamic modelling optical fiber transmission optics and features identification in multiple scales it enables a new multimodal mobile technology for the first time with unprecedented spatial resolution 06 mm1um and realtime functionality at a rate of 210 hz these are enabled by a multimodal petme tracer based on the lifeactvenus protein labeled with 89zr reimaginecrops brings together eight institutions with leading scientists and crossdisciplinary expertise among them eurobioimaging eric and bfedu a large agrifood enterprise will boost the impact and dissemination of this novel technology in to the european scientific and industrial landscape on this basis reimaginecrops has the potential to support and shape the essential priorities in the eus future sustainable crop management
unight the unita researchers night

the key of unight is inclusiveness the project is designed to expand the outreach action of the european researchers night and maximize its impact bringing the event to new cities and to rural semirural and mountain areas that are usually less involved in this kind of event this is possible thanks to the participation in unight of the members of unita one of the european university alliance strongly committed to the valorisation of rural and mountain areasthe activities are conceived to increase the public recognition of rd in terms of impact on citizens and communities daily lives to this aim the project will embrace the approach of horizon europe missions framing the communication in a challengebased narrative that translate critical issues into concrete objectives and make the researchers work tangible and linked to real life unight will also enhance the direct participation of people to the research process by launching a transnational citizen science project to highlight the contribution that citizens can bring to science and the benefit they can get in terms of personal developmentunight will also promote the role of citizens as key stakeholders in the debate on societal challenges and will activate a constructive interaction with policy makers and scientists to this aim unight will create concrete opportunities for opening this dialogue by launching cocreation processes that lead to more inclusive decision policymaking unight will also develop innovative training resources to support researchers in becoming better listeners to citizens needs and concerns and to build a stronger relationship with societyunight intends finally to become an open laboratory for communication and outreach practices where the partners can pioneer innovative actions but also nurture a stronger culture of public engagement within the european academia through the direct connection of unita with all the other european university alliances
decoding extracellular vesiclemediated organ crosstalk in vivo

to coordinate activities between different tissues multicellular organisms critically rely on intercellular communication whereas homeostatic signalling within organs is studied extensively interorgan crosstalk is only starting to be unravelled in recent years extracellular vesicles evs have emerged as central mediators of this pathway by shuttling specific bioactive cargo including proteins between cells these nanosized lipid vesicles are released by virtually every cell type are transported via the blood and combine the intricacy of cellcell contact with the longacting range of cytokines however due to their small size and a lack of suitable approaches to what extent endogenous evs mediate interorgan crosstalk and support custom cargo delivery is unclear i recently developed a unique transparent zebrafish embryo model expressing optical evreporters to examine endogenous ev biology at unprecedented detail in vivo the aim of this proposal is to understand endogenous evmediated organ crosstalk by studying evs secreted by the liver the central metabolic hub in vertebrates to this end i will decode hepatic ev communication routes in vivo in health and liver pathology by exploiting my model system combined with novel tools and highresolution microscopy i will pursue three keyobjectives 1 targets mapping hepatic ev target organs 2 contents analysing custom cargo delivery by hepatic evs to specific target organs 3 function determining the function of endogenous hepatic evs by developing and applying molecular tools to interfere with their release in vivo this project will provide the first advanced mapping of endogenous ev interorgan crosstalk in a living model organism by studying how pathology impacts ev mediated organ crosstalk and gaining precise control over ev release in vivo i will obtain unique insights into ev pathophysiology in turn this will open avenues for optimized diagnostics and therapeutic intervention
ondemand generation of multiphoton linear cluster state

photonic quantum devices promise a scalable way to realize realworld applications of quantum communication and computation an integral part of this vision comprises utilizing cluster states ie a type of highly entangled multiqubit state which provides the fault tolerance needed in almost all quantum protocols i plan to demonstrate the first ondemand multiphoton cluster state source although the realization of an efficient cluster state source has been a longstanding challenge recent improvements in quantum dot spin control and the collection efficiency in photonic crystal waveguides have made this ambitious goal feasible i will use a recently established technique to prepare and cool the nuclear spins surrounding the quantum dot cooling down the nuclear spins will improve the electron spin dephasing time by 20 folds to 50 ns which corresponds to above 99 spin rotation fidelity to improve the photon collection efficiency i will utilize a onesided photonic crystal waveguide which provides a nearunity coupling to a single waveguide mode moreover i will use an inverse design method to improve the chiptofiber coupling efficiency to above 90 the cluster state generation will be implemented with a timebin protocol which entangles the quantum dot spin states with the emission time of single photons using realistic experimental parameters the estimated threephoton cluster state fidelity in this protocol is above 80 the project will achieve a cluster state production rate at 5 orders of magnitude higher than the current stateoftheart devices the successful demonstration of an ondemand cluster state source is a critical step towards scalable and practical photonic quantum architecture
polarization orientation calibrator for cosmology

i will enable groundbreaking results for cosmology and fundamental physics thanks to a novel method for measuring the angle of the polarization plane of the cosmic microwave background cmb photons with unprecedented accuracy existing and planned cmb polarimeters looking for primordial bmode signals need an independent experimental method for systematics control on the absolute polarization orientation the lack of such a method limits the accuracy of the detection of inflationary gravitational waves the efficiency in removing polarized foregrounds the constraining power on the neutrino sector through measurements of gravitational lensing of the cmb the possibility of detecting cosmic birefringence and the ability to measure primordial magnetic fieldsmy 5year project will dramatically improve instrumental accuracy by means of artificial calibration sources flying on aerial drones and tethered balloons within sight of the most advanced ground cmb telescopes operating at highelevation angles and farfield distances the calibrators will make use of linearlypolarized microwave emitters optimally coupled to the simons observatory so polarizationsensitive detectors the worldleading cmb project for the next decade the orientation of the source polarization plane will be registered to absolute celestial coordinates by star cameras and ground photogrammetry with arcminute accuracy polocalc will take advantage of my leading role in so and will operate from its site in the atacama desert in chile this project will become a pivot for the field any existing or future instrument in atacama will be able to observe my novel polarization calibrator and future projects will intercalibrate their detectors with the resulting calibrated observations of sky sources polocalc will produce the first experimentallycalibrated data of the polarization angle of the cmb and its contaminants allowing existing and future cmb polarimeters to fully mine the cosmic sky