Dragon09/odtu_chatbot huggingface dataset:
blood as energy source to power smart cardiac devices

cardiovascular diseases cvd are the leading cause of death globally taking 186m livesyr most cvd are associated with blockage ofblood vessels grafts play a vital role replacingbypassing these vessels but have failure rates up to 50 due to thrombosis or infection vascular grafts of the future would ideally sense and monitor its performance and telemetrically emit dataalerts to healthcare system so that medical actions can be performed to avoid graft failure iomts has taken its first steps but is still far from full potentialdevelopment especially in implantable systems which are limited by the use of batteries to power themthe blood2power project aims to contribute to this paradigm shift by proposing the development of a new way to harvest energy from the body and using it to create the next generation vascular grafts the igraftto achieve this pioneer technology new triboelectric nanogenerators teng will be developed converting mechanical energy from the body into electrical energy a miniaturized ultralow energy consumption power management unit will be developed and coupled to the vascular graft together with a wireless system allowing to store generated energy and collect and wirelessly transmit teng outputs to an external electronic device eg smartphonewatch these systems will be validated in vitro and in vivodriven by these challenges this international team led by a young researcher gathers renown institutions and researchers with unique and complementary backgrounds in biomaterials energy harvesting electronics and medicine
molecular basis and the role of phenotypic plasticity in thermal adaptation

understanding the mechanisms that generate phenotypic variation and their impact on evolutionary processes is central in modern biology when faced with adverse environmental conditions populations survive through two distinct processes phenotypic plasticity ie mechanism in which one genotype produces several different phenotypes depending on the environment or evolutionary adaptation ie pertinent allele frequency changes in population while numerous studies have expanded our knowledge of evolutionary principles the molecular basis and the relative contribution of these two processes to the adaptation is still unknown here i propose to tackle this key question by performing experimental evolution and exposing wildcaught dmelanogaster populations to four temperature selection regimes constant cold temperature constant hot temperature fluctuating between hot and cold and optimal temperature as a control to determine the genetic targets of selection behind the change in thermal tolerance i will perform pooled whole population sequencing of both ancestral and evolved populations the alleles that increase in frequencies between the ancestral and evolved populations will be further validated to determine their effect on the thermal tolerance to understand the contribution of phenotypic plasticity to the process of adaptation i will transfer the evolved populations into a nonselective environment and determine the relative change in thermal tolerance that occurred upon the transfer furthermore to unravel the gene regulatory changes associated with plastic response i will perform atacseq chromatin accessibility assay and rnaseq changes in gene expression of evolved individuals before and after the transfer to the nonselective environment the inclusion of epigenomic and transcriptomic analysis of the evolved populations will enable us to construct a more holistic picture of adaptation
enteric bioelectronics for sensing and stimulating the cns

therapies for neurological disorders often involve deeply invasive brain operations or implants a largely overlooked aspect of these conditions is the high comorbidity of girelated disorders although the topdown relationship between the brain and peripheral organs has dominated the field its now clear that activity of peripheral organs in particular gi innervation the enteric nervous system ens not only influences brain activity but also paces and regulates it indeed recent studies have shown the bidirectional relationship between gut homeostasis and neurological function in disorders such as epilepsy alzheimers and parkinsonsenterbio will adapt bioelectronic tools developed over the past decades for application in the cns for sensing and stimulating the ens and thereby sensing and stimulating the cns the team comprises worldleading expertise in organic and graphene bioelectronics drug delivery in vitroanimal models of neurodegenerative disorders and molecular cellular physiology of the pns we propose to turn this expertise toward the ens to develop a platform for elucidation prediction and control of cns function objectives are to develop bioelectronic sensors stim electrodes and drug deliv targeting ens and adapted for implantation in the gut elucidate ens control of cns using highres sensing signals in vivo demonstrate control eventual therapy for cns disorders without highly invasive implantsenterbio proposes to build on new cuttingedge directions organiccarbonbased bioelectronics and the gutbrain axis to disrupt the field of cns sensingneuromodulation as technology to utilize ens activity as an entry point to brain dysfunction is lacking entering the bio through the gut will be exactly this disruptor enterbio will achieve substantial improvements in relation to the barriers and obstacles of todays sensingneuromodulation technologies
social economy transition skills

sets project aims at developing testing and disseminating suitable skills development programmes and training modules to foster the green and digital transition of social economy organisations seos the project activities will also prepare through a specific ictdriven impact assessment management methodology future scaleup of the project outcomes through other funds cohesion funds eit interprofessional funds and leverage its potential among private and public stakeholders sets will also support the skills development of companies providing digital solutions and innovative technologies and vet providers for seos the project will follow a work plan based on seven interconnected work packages management and coordination wp1 skill gap analysis wp2 development of trainings wp3 piloting and testing wp4 certification and recognition wp5 assessment promotion and scaleup of the project impact wp6 dissemination and communication wp7 the rationale for formulating the sets consortium is based on the creation of a value chain at two levels national level and european level the partnership covers 4 countries be it fr si but the skill gap analysis will be run at paneuropean level as 2 of the beneficiaries are eulevel umbrella organisations or support structures while the testing and implementing of skills development programmes and training will be carried out in france and sloveniathe consortium combines diesis a eu level support structure for seos all digital a paneuropean association working to enhance digital skills tiresia politecnico di milano a technology innovation and research centre for social impact in italyopen impact an innovative startup and accredited spinoff of the university of milanobicocca soga a french thinktank engaged in the digital transition of seos prizma a slovenian nonprofit organisation that develops programmes and projects related to lifelong career orientation
integration of innovative and reliable socioecological models and userdriven solutions into the digital twin ocean to facilitate whatif scenarios and decision support under a cocreation approach

surimis overall objective is to develop socialecological models and userfriendly solutions that will be integrated in an interoperable and standardized manner within the dto to generate policy analysis rooted in management strategy evaluation mse principles the project will develop the surimi toolbox which will 1 provide opensource interchangeable socioecological assessment and policy models including protocols and standards for model and data interoperability 2 ensure the collection and harmonization of data informing these models across eu waters as well as ensuring longterm accessibility of the data and 3 package models data and a visualization interface with a set of accessible and informative usercentric decision support tools including the use of natural language processing nlp artificial intelligence for policy analysis and implementing a mse framework to thoroughly account for benefits and costs of policy implementations the project will integrate every element of the surimi toolbox models data interoperability layer graphical user interfaces as core elements of the dto infrastructure and model lab surimi will cover and generalize broadly across the eu waters while providing input interfaces for users to tailor scenarios to their specific usecases and local twins by inputting their own data and assumptions throughout the entire project lifetime surimi will engage a wide community of stakeholders from research industry advocacy policy and society to cocreate codesign and coassess the surimi toolbox in a demanddriven and responsive development cycle all this 1 expanding the dto to covering ecology economy and society and thus complementing its capacities and uses 2 enabling better management of human activities 3 facilitating whatif scenario analysis decision support and policy implementation both at european and regionallocal scales and 4 contributing to the eu mission ocean restore our ocean and
phosphoinositidelipid signaling in neuronal mitochondrial biogenesis

mitochondrial dysfunction leads to several neurodegenerative diseases and is implicated in neuropsychiatric disorders yet our understanding of how mitochondrial biogenesis is tailored to neurons is very limited my identification of a role for the phosphatidylinositol45bisphosphate pip2 phosphatase synj2 in local mitochondrial biogenesis connects phospholipid signalling with mitochondrial maintenance and mitophagy in axons my lab is already utilizing advanced imaging methods to study rna transport and local mitochondrial biogenesis recent advances in local lipid perturbations now make it possible to also identify lipidmediated regulatory mechanisms of mitochondrial biogenesisthis project spans all the way from mitochondrial biochemistry and signaling mechanisms to neuronal cell biology and local translation culminating in how the molecular effects alter mouse physiology and behavior we have preliminary evidence that pip lipids are involved in the regulation of rna tethering and local translation this occurs at mitochondriaendosome contacts which are enriched in pip lipids likewise contact sites between mitochondria and lategolgi or lysosomes provide pip lipids during mitochondrial fission yet both organelles are rare in axons synj2a which is a neuronenriched splice variant could underlie the special morphology of axonal mitochondria and contribute to axonal mitochondrial fission finally pip altering drugs are used for the treatment of mood disorders and mitochondria and mitophagy have come recently into the spotlight for their role in neuropsychiatric disorders alteration of local mitochondrial biogenesis via altered pip levels may provide a mechanistic link between mitochondria and mood disorders mitopip will be of significance to patients with neurodegenerative and neuropsychiatric diseases as it will advance our understanding of whether restoration of mitochondrial function in axons can be achieved through regulation of lipids
initiation mechanisms of lipiddriven diseases

the metabolic syndrome and its several manifestations have currently taken a tremendous toll on many aspects of society nonalcoholic fatty liver disease nafld is considered the liver component of the metabolic syndrome while atherogenic dyslipidaemia and especially apolipoprotein b apobcontaining lipoproteins is considered the major causal mechanism in atherosclerosis initiation and progression by employing novel humanized mouse models that can be rendered acutely dyslipidemic we have already demonstrated that at the very onset of dyslipidemia apobcontaining lipoproteins interact with immune cells in the liver causing immune and metabolic changes including ectopic lipid deposition this opened to the idea that the inflammatory response evoked by acute dyslipidemia plays a pivotal role in the initiation of other important lipiddriven diseases such as nafld hereafter we present experiments to elucidate novel mechanisms central to the pathogenesis of nafld we will better define the nature of the innate immune cells that firstly react to a dyslipidemic insult this will be accomplished by imaging the different hepatic macrophage subsets after transition to dyslipidemia and by examining the physiological changes caused by liver kupffer cells depletion secondly we will investigate how this initial hepatic response will in turn affect atherosclerosis initiation and progression we will target atherogenic factors secreted by liver immune cells upon apob uptake and inhibit several of them in vivo using neutralizing antibodies finally by employing 2h2o to trace lipids synthetic rates we will clarify whether the hepatic lipid accumulation observed in our mice is of endogenous or exogenous sources this project will yield powerful insights on targetable mechanisms concerning the initiation rather than the endstate of metabolic diseases that are currently endemic to the global population opening to earlier detection and intervention
atmospheric blocking under global warming sources of uncertainty in climate predictions and projections

cold spells heatwaves and droughts have severe socioeconomic impacts and are related to a peculiar phenomenon known as atmospheric blocking accurate and timely prediction of blocking frequency and strength is therefore of enormous importance however despite decades of research climate models still exhibit substantial errors in blocking leading to large uncertainties in seasonaltodecadal predictions and future projections of blocking trends at the root of this is the lack of a fundamental theory for blocking and an appropriate metric to identify blocks a recent theoretical breakthrough offers an exciting path forward by drawing an analogy between blocking in the atmosphere to traffic jams on a highway the traffic jam blocking theory which is based on the conservation properties of largeamplitude nonlinear waves has led to a conceptual simplification of why blocks occur leveraging the promise shown by this new theory atm blocking will provide the firstever assessment of the key dynamical drivers of blocking errors and trends in the stateoftheart global climate models the success of atm blocking will offer a new theoretical basis for evaluating the performance of climate models in simulating blocks with an unprecedented ability to pinpoint the responsible atmospheric processes across timescales down the road these results will help policy makers and stakeholders to prepare for risks associated with climate change and weather extremes the project proposes to address the problem using a combination of theory numerical modeling and statistical analysis at university of bergen norway in close collaboration with the bjerknes centre for climate research under the supervision of leading experts in climate dynamics climate modeling and weather extremes in addition the researchers own expertise in the theory of blocking will ensure the success of the project while facilitating twoway knowledge transfer between the researcher and the host
smart networks and services international and european cooperation ecosystem

the project will create a collaboration environment for european and global stakeholders involved in the preparation of 6g smart networks and services it will be the instrument to present leverage and position the sns ju activities and achievements in major european and global fora the project will work at a global level with other regions where 6g activities are planned and ongoing this will create an environment to promote sns ju results and achievements exchange trends and ideas to achieve global consensus key standardization activities will be also monitored and main roadmaps and trends will be communicated back to the sns ju projects the project will also establish dialogues at a european level between peer horizon europe partnerships national initiatives research and development clusters etc targeting the exchange of information plans and priorities this will enable a better understanding of the european activities among the involved stakeholders and will potentially enable a better alignment of their plansadditionally sns ice will also be engaged in dialogues with key vertical industries through wellestablished associations to identify their requirements and promote the sns ju solutions to them this exchange of ideas will create opportunities for tailorcut 6g solutions and their early adoption by the verticals industriesall these activities are expected to contribute significantly to secure europes leading role in the definition provision and exploitation of 6g solutionssns ice is planning to organize dedicated workshops with the abovementioned groups of stakeholders at main international events most notably techritory and eucnc it will also provide several presentations at international and european conferences and events the outcomes of these results will be communicated to the sns ju community assisting the research and innovation activities to be fully aware of the global 6g progress
european training networks to target damps and nets novel approaches in precision sepsis patient care

sepsis remains one of the major challenges for societies worldwide causing an estimated 79 million deaths every year it is the leading cause of death at intensive care units in the eu this high mortality persists because at present methods for timely diagnosis are lacking and no effective therapy is available therefore there is a clear and urgent medical need to provide novel diagnostics and therapeutics for use in sepsis the praetorian doctoral network has created a doctorate programme to deliver innovative training on preclinical and clinical science business and entrepreneurial aspects intellectual properties and more covering multiple aspects of the drug discovery and development process this programme is unique as it will deliver a new generation of young scientists each doctoral candidates dcs who will collaboratively work to develop novel approaches in precision sepsis patient care providing new diagnostics and therapeutics to answer to an urgent unmet clinical need recent insights have indicated a pivotal role for neutrophil activation and socalled damage associated patterns in the initiation and propagation of sepsis however a comprehensive view on how these processes cause the onset of sepsis remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic and therapeutic solutions praetorian was designed to address this urgent need by bringing together specialists from academia and industry to shape a new generation of entrepreneurial scientists who have skills expertise and knowhow to further our understanding of sepsis pathophysiology into tangible and effective solutions for novel diagnosis and therapy
land use implications of the renewable energy transition

to mitigate climate change most electricity production will have to come from renewable energy re sources a challenge is that re has a much larger land footprint than conventional energy sources current projections of the re transition overlook its effects on landscapes which may lead to unanticipated spillover effects spatial constraints will severely limit the expansion of re capacity due to i competition against other land uses ii public opposition and iii restrictive legislation given the impacts of re infrastructure on landscapes it is therefore essential to understand land use impacts of the energy transition colocating re production with other land uses could decrease the overall impacts of the re transition on land use and ecosystems compared to a spatial concentration of re production with an exclusive use of the landi propose a novel bottomup approach to produce a finegrained understanding of decisions by multiple interacting actors regarding re deployment in landscapes the manner in which the re transition is realised depends on decisions by numerous agents governments landowners re companies civil society organisations etc my approach will lead to a realistic representation of feasible and sustainable pathways to accomplish a re transition at scale i will combine geographical analyses interviews with stakeholders and scenario analysis based on a new spatiallyexplicit multiagent simulation model the project will allow better anticipation of land use impacts of the re transition under various scenarios the project will explore the potential benefits of implementing the re transition based on technologies that can coexist and create synergies with current land uses as opposed to technologies that exclude other land uses a successful and rapid energy transition is essential to mitigate climate change this transformation needs to be realized in a way that minimizes negative spillovers on land use and ecosystems
pregnancy dating challenges technologies and unequal geographies of abortion and childbirth care

pregnancy dating or the assessment of the duration of the gestation is considered the most important step in the management of any pregnancy for obstetric and neonatal care it is on the estimated starting date of the pregnancy that the whole chain of care eg prenatal screening childbirth plans is established and access to a variety of critical pregnancy childbirth and abortion options are regulated although considered a standard procedure pregnancy dating varies greatly in accuracy and methods and across services and countries and depends on technologies resources and skills of those involved in this process pregnant peoples embodied knowledge is often disregarded as unreliable despite bearing major and lifechanging consequences pregnancy dating remains largely unquestioned in the social sciences and in medical and public health literature this has profound effects on how pregnancy has been theorised and empirically studied as well as on legal provisions and clinical practices through pregdat i will transform existing paradigms of understanding and studying pregnancy and reproduction by unpacking the black box of pregnancy dating exposing its sociotechnical and political components of pregnancy time and exploring whether and how these generate unequal access to abortion and childbirth care for different groups in different locations i will lead a multidisciplinary team employing qualitative methods from sts anthropology feminist legal studies public health studies and visual design to investigate the process of pregnancy dating in 4 european countries both in metropolitan areas and in peripheral locations pregdat will reshape scholarly understanding of pregnancy and pregnant subjectivities and temporalities while intervening in the policies practices and regulations of pregnancy and abortion care