Dragon09/odtu_chatbot huggingface dataset:
proving agency in mathematical practice practical social and mental aspects

mathematical reasoning is essential to the development of mathematical and scientific knowledge and is a crucial skill in our science and technologybased european societies yet despite the revolutionary advances in formal logic of the past century the nature of reasoning and proofs in ordinary mathematical practice remains unclearthe provingagency project aims to move forwards on this general question by shifting the focus from mathematical proofs themselves to the activity of proving that gives rise to them the approach to be developed proposes to structure the inquiry around the different dimensions of proving agencythe capacities of proving agents necessary to the realization of the activity of proving the provingagency project will implement this approach concretely within a restricted perimeter in order to investigate three central aspects of proving agency practical social and mentalpractical aspects are concerned with the practical knowledge required by mathematical agents to prove theorems one key element of such practical knowledge is the capacity to apply adapt and extend mathematical methods we will develop here an epistemological model of mathematical methods which will be informed by detailed and representative case studiessocial aspects are concerned with the issues that arise when several mathematical agents are proving a theorem together we will articulate here an account of the shared agency involved in the shared activity of proving together which will be informed by a sociological study to be conducted on a group of mathematicians at the eth mathematics departmentmental aspects are concerned with the mental dimension of the activity of proving we will aim here to provide a conception of proving as a mental activity that does justice to the fact that proving often requires to rely on mathematical artifacts which we will do by building on recent developments in the emerging field of extended epistemology
insurgent temporalities fascism as a global antiuniversalist project

deploying a complex methodological apparatus drawing on transnational history this project breaks new ground by providing an original global history of fascism 19191945 intempo argues that the fascist national revolutions were part of a global project of overhauling the liberal international order and replacing it with a fascist one it does so by approaching transnational fascism through the lens of temporality showing the centrality of a specific temporal structure to fascist ideology fascists everywhere repurposed a historical or mythical past saw their present as a watershed moment in world history and aimed to accelerate it toward a redemptive future of eternal plenitude when time would stand still despite significant variation related to the different national contexts in which fascist movements and regimes emerged the compatibility of this temporal structure translating spatially into distinct but similarly compatible projections of a new order allowed mutual recognition and enabled international cooperation that transcended fascisms ultranationalism the project further shows how fascisms temporal imagination resolutely opposed the universal time regime associated with the spread of capitalism liberalism and colonial expansion fascist temporalities and their revolutionary potential are consequently used as an entry point for elucidating fascisms restructuring of space social space internally and geopolitical space internationally and its complex engagement with capitalism and colonialism respectively the focus on temporality underpinning analysis of the diverse forms that interactions between fascist movements and regimes took allows us to operate across different spatial scales of analysis from the local through the national to the global intempo inaugurates a new research agenda in four distinct fields fascism studies global history the history of empire and colonialism and the interdisciplinary study of temporality
unmasking the dynamic influence of the hematopoietic niche as an oncogenic path to myeloid neoplasms evolution

although oncogenic driver mutations are found in healthy tissues sometimes at a prenatal stage they do not often result in overt cancer this genotype phenotype discrepancy warrens the search for extrinsic mechanisms of cancer development and maintenance such as aging or exposition to specific environments using myeloid neoplasms as a cancer model i aim here at dissecting the hematopoieticniche partnership at the preleukemic leukemic and postleukemic stage to identify innovative therapeutic strategies to prevent acute myeloid leukemia aml development maintenance and recurrence to enable experimental modelling of the bone marrow niche at different disease stages i collected longitudinal paired stromal and hematopoietic primary patient samples and generated physiologicallyrelevant in vitro and in vivo humanized models in this proposal i will first apply largescale pooled genetic screening approaches to gain insights into the role of the hematopoieticniche cellular communication processes in leukemic transformation of preleukemic clonal myeloid conditions in the second part of the proposal i will combine cuttingedge spatial singlecell rna sequencing technologies with functional genetic screening to dissect the leukemicniche crosstalk and ultimately fuel the development of concomitant seeds and soil therapeutic strategies finally i will design a functional singlecell screening approach allowing modulation of the postleukemic niche to open the road for novel maintenance treatment strategies reestablishing healthy hematopoietic stem cells fitness advantage to prevent relapseoverall the proposed research project provides a framework for defining and understanding the dynamic influence of the hematopoietic niche as an oncogenic path to myeloid neoplasms evolution and represents a key step towards therapeutic niche reprogramming from a malignant to a healthy state to improve cancer patients prognosis
digging deep an underground plant trait perspective on diversitydisease relationships

plant species diversity is often associated with reduced disease risk yet the scientific literature on diversitydisease relationships is unclear showing conflicting relationships this conflict highlights a major knowledge gap in our understanding of the mechanisms underpinning the diversitydisease relationships overcoming this gap is essential for transforming agricultural systems from monocultures that are sensitive to disease outbreaks to diverse cropping systems that are intrinsically resilient to pathogensi aim to significantly advance our understanding of diversitydisease relationships in plants i will transform our knowledge on belowground plantpathogen interactions by integrating three advances from animal epidemiology 1 host quality diversity in epidemiological traits has proven key to understanding disease dynamics in animals i will systematically quantify such variation in plants and their consequences for disease risk2 pathogen protection microbes can protect animals from pathogen infection i will investigate the role of symbiotic mycorrhizal fungi amf in belowground pathogen protection in diverse plant communities 3 contact networks pathogen transmission ultimately depends on contacts within the community plants are obviously sessile but their root systems are not by navigating the soil they may interact with different neighbouring plants i will examine how the nature of these root contact networks affects disease risk i propose that plant traits are a bridging link between these epidemiological advances i will use experimental and modelling approaches with a range of grassland species and three soilborne fungal pathogens i aim to transform our understanding of belowground plantpathogen interactions in biodiverse systems with multiple pathogens stimulate crossovers with phytopathology and animal epidemiology and provide a knowledge base to design agricultural systems that are intrinsically resilient to pathogens
eavesdropping on bacterial gossip in biofilms for resource recovery from wastewater

biorescue delves into the role of bacterial quorum sensing a celltocell communication in wastewater biofilms the hypothesis posits that quorum sensing holds a key role to understanding biofilm formation and that introducing exogenous quorum sensing signaling molecules in highrate activated sludge biofilms has the potential to enhance biopolymer production and bioflocculation as the global water community increasingly recognizes the untapped potential of wastewater as a resource for green energy and biopolymer this project aims to address a significant knowledge gap in the field i will develop advanced bioanalytical techniques combining bioassays with chemical screening to explore uncharted diversity concentration and activity of signaling molecules in wastewater biofilms i will explore the doseeffect relationship of signaling molecules in highrate activated sludge to offer practical strategies for optimizing resource recovery by combining this unique dataset with a detailed analysis of bioflocculation and biopolymer composition i seek to uncover valuable insights on the role and effects of quorum sensing in biofilms implemented at the aarhus university and the host research group this project will allow me to enhance scientific communication and project management skills through a welldesigned training program courses workshops regular meeting with supervisors as well as measures for knowledge exchange and dissemination aligned with un sustainable development goals particularly in the interests of clean water affordable energy and sustainable industries this project has the potential to revolutionize wastewater treatment transforming treatment plants into net energy producers and fostering sustainable resource recovery thus addressing pressing global challenges while advancing scientific understanding and innovation in wastewater treatment
bioinspired fullspectrum blockcopolymer photonic structural pigments

photonic pigments are one of the most exciting topics in optics as they are expected to lead to a pure and brilliant colouration free from chemical or photobleaching which is a central goal in the future developments of paints cosmetics displays and advanced photonic devices till now most efforts have been focused on amorphous packings of colloidal crystals but limitations of synthesizing large quantities of photonic pigments based on these arrays are only beginning to emerge novel materials and approaches are thus necessary and in this context colour aims to develop bioinspired photonic pigments via the combination of structural colouration and light absorption the key approach is to exploit the 3d selfassembly of block copolymers in concentric lamellar structures to generate fullspectrum photonic crystals with high reflectivity and angular independence coupling these with broadband absorbers to ensure colour purity and vividness specifically highvisibility structural colour able to address the limitations of current photonic pigments will be achieved by altering four variables namely size blackness refractive index and arrangement of the nanoelements colour will rely on my competencies in polymer processing and characterization and the expertise of the host supervisors prof ullrich steiner and prof christoph weder in the domain of soft matter physics polymer selfassembly supramolecular polymers and materials science outgoing phase adolphe merkle institute university of fribourg switzerland and prof davide comoretto in photonics incoming phase department of chemistry and industrial chemistry university of genova italy colour offers me the unique opportunity to acquire technical skills and experiences in several scientific fields that will be crucial to advance my career towards an independent academic position as well as exposure to a technological problem of significant scientific societal and technological impact
demonstrator of industrial carbonfree power generation from orcbased wasteheattoenergy systems

energy efficiency of intensive industrial processes and particularly waste heat recovery technologies have been identified by international and regional organization like iea eu or ademe in france as a major game changer for co2 emissions reduction the decagone consortium led by enertime proposes a project demonstrating the potential of orc technology in waste heattopower conversion for selfconsumption of industrial plants at a large industrial scale targeting the waste heat potential of the company tineck elezrny mother company of partner energetika trinec located in czech republic and historical manufacturer of iron steel the decagone project will develop a an innovative orcbased whr system using enhanced capture designs and disruptive turbomachinery the proposed hermetic turbogenerator design will run on innovative active magnetic bearings for increased compacity higher availability and safety and cost reduction with nearzero maintenance dedicated studies improve organic fluids or mixtures for higher stability and improved transposability to other industries the project will also provide advanced monitoring using innovative probes iot and machine learning algorithms for realtime efficiency improvement within the scope of the project at 6 others significant industrial sectors will be evaluated in terms of potential market and transposability at the european scale aluminum gasenergy oilgas glass lng and cogeneration new financing and business models will also be investigated supporting long term operations of the erected assets coping with longlasting and resilient industrial processes the use of the esco model to contract finance and operate energy efficiency facilities will be part of the project preparing for the future operation of the facility by a specialized company lastly diffusion of good practices all over europe will use european partners in the consortium in coordination with regional energy agencies
how has the rapid scale up of malaria control in africa impacted vector competence

the malaria parasite plasmodium falciparum is responsible for more than 200 million cases and 400000 deaths each year with over 90 of cases occurring in africa the parasite is reliant upon anopheline mosquitoes for transmission and insecticide treated bed nets targeting these mosquitoes represent the single most efficacious way to reduce case numbers and hence deaths however due to the use of pyrethroid insecticides on all distributed insecticide treated bed nets insecticide resistance now threatens the impact of these interventions analogously deaths from active malaria cases have been decreasing through the successful use of drug therapy however resistance to every class of frontline drug has now been described incredibly we simply do not know the impact of current vector control tools on parasite development nor the impact of drug resistance on development within the mosquito vector despite fine scale characterisation in the erythrocytic stages with the stalling of progress in malaria elimination and the addition of new chemistries to insecticide treated bed nets it is time that we invested in understanding precisely how our current vector control tools affect the parasite in order to avoid catastrophic failure of malaria control to this end i propose to i determine the impact of insecticide use on parasite development in the contexts of species replacement insecticide resistance and insecticide exposure ii elucidate the changes due to parasite drug resistance on mosquitostage development iii ascertain genetic interplay between mosquito immunity and response to insecticides to identify new targets that negatively affect insecticide resistance and parasite development the results generated from this multidisciplinary proposal will redefine our understanding of factors determining vector competence under contemporary transmission settings and will identify alternative options for intervention
writers and the teaching profession a digital archive of teachers voices from the history of italian literature

many writers across different literary traditions have been working as teachers and thus school has often been not only a space of canon transmission but also a source of literary inspiration yet the relationship between writers and the teaching profession has not received the critical attention it deserves wrichers aims at addressing this lacuna and developing an innovative theoretical framework to study the possible interactions between writers and teachers careers from a literary perspective in order to achieve such a goal the project wants to build a digital archive that will allow to 1 explore categorise analyse and critically assess the specific functions of teaching experiences in the literary careers of 20thcentury italian writers 2 prove the literary value of a number of texts produced by writers in school contexts and often downplayed as mere bureaucratic documents 3 examine the ways in which italian writers dealt with their involvement in school teaching while managing their public image as writers wrichers will address a gap in the field of italian studies but the theoretical framework resulting from the research will be designed in a way that will make it applicable to other literary contexts specifically the project will collect a large set of relevant data and hitherto invisible archival documents the core of the archive will consist of teachers journals penned by writers that currently risk to stay inside dusty boxes spread in different school archives all across italy and will make them freely available not only to scholars from different disciplines but also to the wider public beyond academia wrichers has the ambition to raise awareness of why school archives are sites of cultural heritage and how this heritage can be enhanced by local school communities finally the project may also contribute to improving the attractiveness of the teaching profession by highlighting the role of teachers as important cultural actors
on the substantiality of aristotelian substances

substances are the fundamental entities in aristotles ontology sensible substances paradigmatically individual biological organism are constituted by a form or organisational structure and some matter there are in particular two features characteristic of sensible substances being separate ie being independent in some sense and being a thissomething ie being an individual or something definite in some sense what these two features exactly amount to is clearly crucial for an understanding of aristotles conception of substance however it is unfortunately also notoriously obscure and highly controversial in the literature the purpose of this project is to clarify these two features and thereby to advance the literature on the notion of substance and to provide new insights for important debates in contemporary metaphysics central in my project is a novel methodology based on myles burnyeats influential work this twolevel methodology reflects aristotles own methodology to distinguish two levels of discourse one where a subjectmatter is discussed from a more abstract perspective and one where it is discussed from a more comprehensive causal perspective this methodology provides the means to interpret the different passages in aristotles works in a contextsensitive way that allows to relativise the scope of certain assertions made there employing this methodology allows me to resolve a central dilemma about the notion of separation consisting in the fact that there is prima facie good reason to assume three jointly incompatible assumptions 1 forms are substances 2 being a substance implies being separate and 3 forms are not separate this method also provides the means to deal with prima facie problematic consequences of a straight forward but largely rejected interpretation of separation and to illuminate a largely neglected but important aspect of being a thissomething related to final causality
innovative patented dry fermentation technology for costeffective and highly nutritious production of hybrid myceliumplant meat analogues

in a public enquiry made by the european commission 80 of respondents were willing to reduce their meat intake to help reduce the emission of greenhouse gases ghg and 74 intended to change their diet to improve their health however current meat analogues in the market are not a healthy alternative since they are ultraprocessed full of binders and additives and among their ingredients we can find high amounts of sugars and sodium maltodextrins or soy isolate that are not indicated for a healthy diet in addition these products are nor ecological since they are highly resourcedemanding mainly in terms of water consumption wastewater generation and energy use and also cause important ghg emissions on top of that the existing meat analogues are rejected by consumers due to their offtaste bad texture that does not resemble to meatin response to this situation millow has developed to trl6 a novel solid state dry fermentation production technology for myceliumplant meat analogues this highly scalable and costeffective innovative process accelerates mycelium growth from most typical 37 days periods to 24h reducing required water input by 97 energy use requirements by 67 and co2 footprint by 95 compared to benchmark methods based on liquid fermentation the resulting products have neutral taste pleasant texture that mimics meat attributes without the use of artificial binders is minimally processed healthy nutritional and ecofriendlyin the meatlow project we aim to optimise and automate its innovative technology to reach trl8 and commercial status and introduce our disruptive plantfungi products in the eu meat substitute market by 2026 to do that our highly skilled team of scientific management and marketing professionals is determined to lead this project to success
assessing feedback responses of soil erosion through the lens of variable sediment connectivity during extreme events in semiarid catchments

soil resources in semiarid regions are rapidly degrading posing an imminent threat to food water and livelihood security caveats in our understanding of geomorphological responses to extreme events are a major hindrance for attributing soil erosion and sediment flux dynamics to environmental drivers using the burdekin and makuyuni catchments as natural laboratories for semiarid regions the asforeseen project will assess feedback dynamics in soil erosion through the lens of variable sediment connectivity to test the hypothesis that extreme events can trigger regime shifts towards highly connected ephemeral gully networks the proposed knowledge transfer strategies will bring the researchers scientific and analytical skills to the international standard underpinning his ambition to combine academic and consultancy work within a leading european research institution the researchers unique skillset will be applied to develop novel approaches and integrate them with established techniques in an openaccess diagnostic toolkit to support targeted soil and water management interventions temporal dynamics in fine sediment and phosphorous transport will be quantified using highfrequency sensors and sediment dating techniques we will be the first to evaluate the use of secondary weathered metal species as tracers providing a new pathway for attributing the contribution of gully erosion in deeply weathered or alluvials soils stream monitoring and sediment source tracing outputs will be integrated in a dynamic sediment budget to elucidate nonlinear geomorphological responses to extreme events and land use changes as a source of innovation we will couple a machinelearning gully quantification tool with a dynamic catchment model wherein gullies are both a direct source of sediment and a driver of changing sediment connectivity the hybrid model will be used to test the efficacy of gully remediation strategies under current and future climatic conditions