Dragon09/odtu_chatbot huggingface dataset:
capacity building nexus for monitoring water quality in multistressor areas pilot study at the hellenic volcanic arc

the nexusmonarc project proposes a set of capacity building actions targeting to advance the profile of staff at the department of geology and geoenvironment and collaborating groups at the national and kapodistrian university of athens through these actions a holistic approach to environmental monitoring will be developed for the marine environment of the hellenic volcanic arc in the mediterranean sea an environment that is influenced by multiple stressors of anthropogenic and natural origin such as maritime transport fisheries industrial tourism volcanic activity hydrothermal venting and others the project objectives will be achieved through transferring knowledge and best practices based on the extensive expertise of partner institutions and by orchestrating citizen science activities short scientific missions synchronized to citizen science activities will lead to the development of novel collaborative research projects for the coordinating and partner institutions furthermore twinning activities will incite local and international stakeholders from public policy and industry to participate and contribute to educational and scientific actions thus actively improving the marine environment and protecting its inhabitants owing to training and collaborative actions the improved administrative and management practices of the nexusmonarc will be readily applicable to other multistressor marine environments in the world
phenomenological analysis of ipseity and the nature of suffering

pain is a leading cause of disability globally with approximately one in five adults across europe reporting persistent pain that seriously impacts their lives the growing personal and societal costs of pain have resulted in strong calls for innovative research to better understand the nature of painrelated suffering and how it can be effectively relieved indeed there have been important developments characterizing painrelated suffering including its central feature disruption of ones sense of self disruption of the self may include a loss or alteration of ones selfidentity due to pain eg loss of a valued work role or activity feeling overwhelmed or consumed by pain or a painful body part feeling alien or disconnected from oneself however there is now a clear gap in the current scientific literature on painrelated suffering little research has explored how ones sense of self may be optimally restored or reconstructed through clinical interventions or selfmanagement strategies before we can conduct this kind of empirical research we first need to develop new painrelevant research methods and theory to examine selfhood restoration and reconstruction first this project will develop and implement new qualitative methods to study how clinical interventions and selfmanagement strategies deemed successful by pain sufferers have restored or reconstructed their sense of self combined with a robust synthesis of literature and expert consultation these findings will enable the development of the first comprehensive and empirically grounded framework that specifies how various aspects of the self may be disrupted restored or reconstructed this project will conclude with a series of evidencebased recommendations to help healthcare professionals collaborate with their patients to better target facets of the self to alleviate suffering
dynamics of nitrous oxide release to the atmosphere under coastal hypoxia

the dynox project will elucidate the role of seasonal hypoxia as a driving mechanism for the exchange of the potent greenhouse gas ghg nitrous oxide n2o across the sedimentwaterair interfaces in anthropogenically impacted coastal regions to this end the applicants propose to employ a comprehensive and innovative observational approach in lake grevelingen netherlands which is a saline coastal reservoir that experiences seasonal hypoxia as a result of limited water exchange after two dams were built in the 60s70s the measurement strategy will consist of novel shipboard measurements laboratorybased incubation experiments and analysis of archived samples this comprehensive approach will allow an unprecedented analysis of the fluxes of n2o from a shallow coastal ecosystem their natural variability in response to the onset of seasonal hypoxia as well as potential changes with further ocean warming and deoxygenation and the underlying microbial responses dynox will not only close gaps in data and fundamental understanding in the field of earth and environmental sciences but will also provide valuable data to the essential ocean variables framework of the global ocean observing system and serve as a scientific basis for issuing recommendations to local authorities on priority locations for costeffective environmental monitoring hence the project will contribute to the research and innovation framework programme horizon europe within the mission area healthy oceans seas coastal and inland waters as well as to the un sustainable development goals sdg by addressing sdg 13 climate action and sdg 14 life below water the project will be carried out during a fellowship at the department of earth sciences at utrecht university under the supervision of professor caroline slomp and is expected to promote substantial progress in the scientific career of dr arvalomartnez who aims to establish himself as an independent research group leader
cancer agnostic immunotherapy prediction bloodtest

cancer is the second leading cause of death worldwide accounting for 10m deaths in 2020 although 7 immune checkpoint inhibitors ici are approved for different cancer indications and have represented a true breakthrough only 1050 of advanced cancer patients respond to the treatment this unpredictability of results together with 1560 severe toxicity rates and high prices are restricting the impact potential of icis predicting ici response is critical for fully realizing their potential in treating earlystage tumours and enhancing ici treatment regimenspamgenes iopener is a groundbreaking in vitro diagnostics testing platform for ici response prediction made possible by pamgenes proprietary microarraybased kinase activity profiling of host immune cells it can predict a patients response before ici therapy is started from a simple blood draw the iopener aims to revolutionize the precisionmedicine sector enabling the widespread use of icis at any cancer stage
particle emission prevention and impact from realworld emissions of traffic to secondary pm of urban air

mobility is essential to our modern world to move people and goods between places and countries to serve needs relating to food energy and all human necessities however mobility and its benefits do not come without harm all transport sectors are substantial emitters of greenhouse gases and air pollutants furthermore transport sectors particularly aviation and maritime are difficult to decarbonise by electrification hence the combustion engines and turbines will remain in use for the foreseeable future energy efficiency increases and carbonneutral fuels will reduce the climate impact of these technologies but solutions are needed also to remove exhaust emissions completely including those formed through secondary reactions in the atmosphere particulate matter pm25 emissions are especially harmful causing premature deaths and significant harm to humans and all global ecosystems the parempi project will reveal the contribution of the secondary aerosols seca from transport sources to ambient pm25 levels via increased understanding of precursors their atmospheric reactions and by a novel digital software epmi module to be developed in the parempi project in combination with toxicity and health impact assessments quantification of transport externalities will be improved the consortium members are topscientists in the research of the precursor emissions seca formation and health impact of aerosols many of them have focused in these topics all their careers and earlier collaboration assure seamless work consortium members have experts also on road nonroad marine and aviation sectors and on the emissions standards thus the consortium is capable of formulating sound policy recommendations based on scientific evidence obtained the parempi results efficiently disseminated communicated and exploited have the potential to significantly contribute to the goal of making transportation systems in europe clean secure and efficient
evaluating the robustness of noncredible text identification by anticipating adversarial actions

as challenges posed by misinformation become apparent in the modern digital society stateoftheart methods of artificial intelligence especially natural language processing nlp and machine learning are considered as countermeasures indeed previous research has shown that nlp solutions can detect phenomena such as fake news social media bots or usage of propaganda techniques however little attention has been given to the robustness of these approaches which is especially important in the case of deliberate misinformation whose authors would likely attempt to deceive any automatic filtering algorithm to achieve their goalsthe goal of the erinia project is to explore the robustness of text classifiers in this application area by investigating methods for detecting adversarial examples such methods aim to perform small perturbations to a given text piece so that its meaning is preserved but the output of the investigated classifier is reversed to that end previously unexplored directions will be pursued including training reinforcement learning solutions and leveraging research on simplification and style transfer finally the developed tools will be used to check the robustness of the current stateoftheart misinformation detection solutionsthe project includes a range of training activities for the researcher and a plan for dissemination of the obtained results to various research communities it also takes into account the society at large as the project outcomes can inform further discussion on whether automatic content filtering is a viable solution to the misinformation problem
disaster resilience for extreme climate events providing interoperable data models communication and governance

the recent droughts in central europe and unprecedented floods in central europe have disclosed our vulnerability to extreme weather events besides climate change as a driver of more frequent and intensifying weather extremes demographic change and socioeconomic development exacerbate severe impacts international frameworks for disaster risk reduction and climate change adaptation eg sendai framework eu strategy on adaptation to climate change acknowledge the critical need for integrating risk governance communication and operational mechanisms for coping with extreme climate events throughout the entire disaster risk management cycle directed aspires to foster disasterresilient european societies by expanding our capabilities to communicate utilise and exchange stateoftheart data information and knowledge between different actors boosting the integration accessibility and interoperability of models facilitating knowledge sharing improving dialogue and cooperation encompassing all levels of actors based on enhanced community engagement and developing new governance and risk management strategies using a bottomup valuedriven codevelopment approach key to supporting interoperability will be the establishment of the datafabric an innovative governed cloud platform that enables secure flexible discovery and sharing of all structured and unstructured data central to directed are four real world labs that codevelop new governance interoperability and knowledge production frameworks and demonstrate their benefits for enhanced disaster risk governance supported by innovative technical frameworks to access transform and integrate data and models into customised workflows for creating actionable solutions the real world labs ensure the project continuously and actively involves key stakeholders in the codevelopment process and address topical problems of multihazard risk management and climate change adaptation to maximise impacts
computation driven development of novel vivolikednananotransducers for biomolecules structure identification

the link between the structural change of a molecule and its function is of fundamental importance since it provides direct insight on mechanism of complex biological processes recent years have witnessed noticeable advances of analysis of complex molecular conformations however the understanding of their conformational dynamics remain a formidable challenge and revolutionary advances are still demanded the analysis of chemical composition and structure of biomolecules however the understanding of their conformational dynamics remains a formidable challenge and revolutionary advances are still demanded molecular machines such as the dna itself which work at the core of many cellular activities is able to dna modify its conformation and to transduce the signal upon binding to specific proteins in this project we will develop a dnananotrasducer for realtime detection of conformational changes and the analysis of molecular dynamics as it occurs invivo biological processes the project aims to provide i the development of dnananotransducers that can perform both detection and conformational analysis of molecular dynamics in one functional unit ii use bioinformatics approaches to predict 3d structure of conformational states modelling real time evolution of interacting dnant and proteins and machine learning ml models to directly link the atomistic structure conformational state and dynamics iii assess proteindnant binding by experimental approaches using linear and onchip nonlinear spectroscopies for the detection of vibrational signatures of organic molecular systems to recognize consequent structural changes in the optical signal in realtime iv describe dnantprotein interactions at the cellular level and 3d analysis of dnant and model proteins towards drug discovery these research efforts will provide a foundation for a next generation of dnananotransducers to be used for highthroughput functional molecular structure
how global corporate tax avoidance fuels the wealth inequalities that undermine democracy

this project develops a new theoretical framework and causal mechanism to explain how corporate tax avoidance fuels the wealth inequalities that undermine democracy it implements new methodological innovations that explain how global capital evades the fiscal constraints of democracy using a combination of forensic accounting inperson interviews computational text analysis and original survey experiments the objectives of the project are guided by two overarching research questions why is concentrated capital and wealth inequality a problem for democracy what is the role of corporate tax avoidance and law in enabling this process the empirical and comparative case study analysis are designed to answer these questions first we explain the global wealth chains and tax avoidance structures of big tech and big pharma multinational groups second we explain how legaltechnical actors create these structures and strategies third we explain how their wealth protection strategies destabilise the functioning of democracy fourth we explain the role of the media in politicising corporate tax avoidance as a problem for democracythe project has four work packages first we construct a new theoretical framework typology and causal mechanism to explain how corporate tax avoidance leads to the wealth inequalities that undermines democracy second we explain the tax avoiding wealth chains of big tech and big pharma using a combination of forensic accounting and statistical mapping techniques third we explain how legaltechnical actors create these structures using a combination of inperson interviews list survey experiments and computational text analysis fourth we implement a crossnational survey experiment to explain the role of the media in disrupting the political consensus of legaltechnical experts finally we develop a set of new normative principles to guide how governments can respond in a democracyenhancing way
new players in the regulation of dna replication fork speed

faithful eucaryotic cell division requires spatiotemporal orchestration of multiple sequential events among the crucial steps to providing the daughter cells with identical set of chromosomes is the dna replication during this phase cells coordinate the speed of dna synthesis with the length of the cell cycle to ensure genome integrity to do so growth factors and metabolic signals are integrated primarily by dtype cyclins indeed their deregulation can directly lead to some of the hallmarks of cancer by causing proliferation that is independent of normal extracellular cues we previously demonstrated that aberrant accumulation of cyclin d1 results in a faster cell cycle with uncontrolled speed of dna replication fork progression and genome instability maiani milletti et al 2021 despite frequently altered in many tumors musgrove et al 2011 a unifying theory that clarify how cyclin d1 promote cancer transformation is still lacking in the lab of prof jiri bartek it was previously shown that parp1 inhibition increases replication fork speed mayamendoza et al 2018 parp1i uncouples the leading and lagging dna synthesis resulting in fast fork speed and genome instability however it is currently unknown whether the aberrant accumulation of cyclin d1 has similar effect on dna synthesis as parpi furthermore it is also undetermined whether aberrant levels of cyclin d1 could trigger metabolic changes that accelerate the speed of dna synthesis taking advantage of our previous observations we aim with this proposal to i identify metabolic signatures that can predict disregulated dna synthesis in response to cell cycle alterations ii define the molecular mechanism of how cyclin d1 accumulation induces accelerated fork speed iii identify new metabolic genes involved in the control of s phase progression and the speed of dna synthesis by crisprcas9 screening technology iv suggest druggable targets that could be used in cancer therapy
development of bottomup customfunctionalized grapheneporphyrin nanoarchitectures with atomic precision

the ongoing miniaturization of electronic devices has been raising awareness for the need to develop alternative highperformance and energyefficient semiconductor materials the current project graphyrin aims to synthesize new atomically precise hybrid nanoarchitectures comprising graphene nanostructures graphene nanoribbons gnrs or nanoporous graphene npg and porphyrins pors with promising properties to fabricate nextgeneration materials to be used for example in gas sensing electronic devices first multistage organic synthesis will be carried out to obtain individual or fused precursors of gnrs and pors seeding stages which will later allow the construction of partially and fully conjugated hybrid systems here we will synthesize appropriate bianthracencebased reactants or equivalent derivatives as molecular building blocks of gnrs and in parallel several pors tetra or disubstituted with appropriate structural features to functionalize gnrs alternatively porfused gnrs hybrid precursors will be synthesized via direct functionalization of pors with gnrs precursors or via synthesis of gnrs precursors bearing aldehyde groups several polymerization strategies will be explored growing stages using insolution synthesis iss or onsurface synthesis oss namely on au111 surfaces the polymerization reactions will involve for example suzuki or ullmann coupling depending on the properties of the starting gnrs and por precursors the final structures may either be one or twodimensional 1d gnrspors or 2d npgpors respectively finally the successfully synthesized hybrid materials will be explored as gas sensors for future electronic devices it is expected that the outcomes from graphyrin will allow to go beyond the stateoftheart and take a step further towards the synthesis of new custommade graphenepor nanoarchitectures for ideal gas sensing electronic devices
integrated pathways advancing safe and sustainable by design material innovation through collaborative wisdom

the aim of desiderata is to test and validate the the ecs ssbd framework on selected industrial use cases that are already at trl4 and which will aim at substituting substances of concern soc with surfactant plasticising and flame retardant properties the twofold aim will firstly generate a remarkable impact by advancing industrial value chains in the domain of construction injection moulding 3d printing etc by providing tangible advancement for soc substitution for which there are no currently available solutions on the market secondly the lessons learnt will support policymakers in continuing shaping the ssbd framework improving its applicability and fostering its wider application in the european chemical and material manufacturing sectorto better track the progress of the project 5 objectives have been proposed linked to the expected outcomes of the project and the scope of the topic obj1 demonstration and proof of concept of the ssbd framework achieving policy engagement obj2 development of new ssbd compliant substances and materials obj3 enhancing interoperability for data sharing across value chains obj4 promoting safer and sustainable substances across value chains obj5 maximising the impact of the project a collaborative approach with industry and citizensto achieve the objectives desiderata will cover a period of 48 months and its performance will be structured into 9 work packages wps these include the project consortium management wp1 supported by the interoperability and data management wp7 the stakeholder and policy engagement wp8 and the dissemination communication wp9 of the results obtained the scientific and technical activities are undertaken in wps 2 to 6 which include the use cases design and implementation wp2 sustainability assessment wp3 environmental safety wp4 the ssbd framework assessment demonstration and refinement wp5 and the innovation management wp6
career development of international talents of the energy research fields in the iberian peninsula

talent4iberia programme aims to promote research excellence in the iberian peninsula with primary focus on the extremadura ecosystem of science technology and innovation secti by offering 10 interdisciplinary and intersectoral fellowships with a duration of 36 months for the mobility and training of postdoctoral researchers of any nationality to develop rd activities in the field of energy storage in extremadura within the spanishportuguese and international cooperation framework with the purpose to promote the development of their professional careers in an exceptional research environmenttalent4iberia will be promoted and coordinated by the council of economy science and digital agenda of the autonomous community of extremadura spain the unit with competences in research policies and programmes in the region the programme will be implement by 3 spanish recruiting institutions the foundation fundecyt science and technology park of extremadura iberian centre for research in energy storage fundecytciiae the university of extremadura uex and the centre for scientific and technological research of extremadura cicytex and will count with the participation of 21 associated partners 13 universities 4 research centres and 4 companies dedicated to the energy sector from 15 different countries 8 eu member states spain estonia finland germany italy portugal slovenia sweden 1 he associated country norway and 4 other third countries australia chile switzerland united arab emiratesthe project is aligned with one of the research lines selected as a priority in the participants policies energy storage with an international and interdisciplinary conception it will also contribute positively to the development of territories with a high potential for scientific and technological development in the field of energy and will serve as a pilot in the implementation of the hrs4r of the participating entities