Dragon09/odtu_chatbot huggingface dataset:
precisionadjustable singlesystem decisionmaking

much contemporary research on decisionmaking purports that the brain has two distinct systems which can be used modelfree or modelbased modelfree allows for fast and automatic choices but with a higher likelihood of errors modelbased allows for contextspecific adaptability but with greater cognitive computational costs in contrast to the prominent accounts of modelbased vs modelfree decisionmaking i propose that the brain has a single decision system which can be tuned to be more or less precise by investing more or less cognitive resources the degree of precision determines whether the system appears to be more modelfree or more modelbased for any given decision if successful this project will play a critical role in redirecting a large subfield of important decisionmaking and learning research if unsuccessful this project will provide powerful evidence that the current paradigm is correct
dialoguingrts advancing cultural literacy for social inclusion through dialogical arts education

drts is a catalyst for increasing social cohesion and inclusion using embodied performing arts activities to develop cognitive and affective cultural literacy we recognise that the performing arts encompass massmarket consumer goods as well as nonlinguistic embodied and social activities providing massive opportunities for inclusive participationour target groups comprise actors of all ages and social positions especially in the school system and in community arts initiatives we will empower these groups to be artistically active dialogically related and culturally literate giving them tools and motivation to improve their own situations and those of others within the overall frame of a cohesive european society informed by global perspectivesusing the postcolonial insight that culture is necessarily heterogeneous drts has four related objectives1 understand how performing arts activities relate to cultural literacy in official discourse and documents across partner countries2 use this understanding to build dialogues and cocreate physical and digital actions with heterogeneous groups within our target audience3 develop assessment tools for these actions enabling measurable growth in cultural literacy4 use our findings in recommendations for cultural and educational policies that build longterm social cohesion and inclusionbased on these objectives the overall outputs comprise1 documentary survey and participatory research findings2 performative dialogart actions for cultural literacy3 policy and practice recommendations to increase social cohesion via cultural literacy actions inspired by the performing artsdrts imagines new futures and creates hope and social cohesion through performing arts education by creating participatory spaces and facilitating dialogues we empower voices seldom heard drts thus advances cultural literacy and enhances social cohesion and resilience to build an inclusive future for europe
disruptive and high accuracy test for early colorectal cancer detection in blood

amadix is a leading molecular diagnostics company led by roco arroyo focused on liquid biopsy developing innovative diagnostic tests for early cancer detection in blood colorectal cancer crc is the 2nd leading cause of cancerrelated deaths worldwide most of these cancers and deaths could have been prevented by increasing the use of recommended screening tests that detect premalignant lesions called advanced adenomas colonoscopy is the gold standard screening method although it is an invasive and expensive procedureamadix has previously developed an innovative bloodbased test for crc diagnosis colofast based on an initial combination of cuttingedge biomarkers micrornas and validated in 1000 samples indicated to screen healthy population from 50 to 85 years oldhas shown superior performance in early cancer detection than any of the tests commercialized better compliance and costeffectiveness and is being validated in a european prospective study with 3100 patients recruitment concluded granted by sme phase 2 with 28m amadix has identified new promising biomarkers to be incorporated to the initial signature to improve the diagnostic performance amadix has taken advantage of the potential of artificial intelligence and big data to identify crc risk factors from the patients clinical records and develop diagnostic prediction models our goal is to validate this new signature prevecol more accurate than the initial combination based on different types of biomarkers followed by its commercialization as ldt and as ivd kit in addition a risk factorsbased algorithm will be incorporated enabling to predict and identify individuals with a high risk of developing crc or premalignant polyps even if they are younger than 50 years old improving their survival consequently amadix expects to reach between 20232032 accumulated revenues of 1997m from the commercialization of prevecol in europe and usa
noncanonical rna caps cellular reaction to environment and stress

the goal of this project is to understand the role of noncanonical rna caps mainly dinucleoside polyphosphates npnns in prokaryotes and eukaryotes the 5 termini of the rna are critical structures and are the least characterized among rna modifications in this project we will develop selective capturing techniques for identification of npnnrna sequences and identify the interacting partners of npnnrna furthermore we will reveal their metabolism and their role in cellular reaction to stress conditions in prokaryotes and eukaryotes until recently only canonical structures nad or coa have been known as 5 rna caps we discovered an entirely new class of 5 rna caps dinucleoside polyphosphates npnn in prokaryotic and eukaryotic cells based on our preliminary data we know that methylated npnn caps stabilize rna of e coli in the stationary phase and that some npnn caps can also be found in mammalian cells we do not yet know 1 the sequence of rnas capped with npnns 2 how many types of npnn rna caps exist in eukaryotes 3 whether rna stabilization is their only role 4 why there are so many types of npnn rna caps we identified nine in e coli 5 whether npnnrna can be translated etc the role of free npnns identified fifty years ago is yet to be elucidated npnns are called alarmones as their concentration increases under stress conditions the mechanism by which the alarm is recognized in cells is unknown i presume that their cellular effects are mediated by the rna where they serve as rna caps as such they become an important part of rna metabolism and can be recognized by various rna interacting proteins triggering additional effects in cellular metabolism the presented project has the potential to solve the puzzle of the role of npnns and clarify the connection between rna metabolism and immune response or virulence factors of viruses and bacteria
microgliasynapse molecular interactions in neurodegenerative disorders

microglia are immune cells that monitor our brain and degrade unhealthy neurons and excess synapses in alzheimers disease ad however microglia excessively destroy synapses marking them as enticing treatment targets ad patients accumulate cortical amyloidbeta a plaques and neurofibrillary tau tangles whilst losing neurons and synapses and consequently memory and cognition microglia are the brains immune cells mediate neuroinflammation continuously monitor their surrounding cells and prune eliminate excess synapses during development interestingly various ad risk genes are highly expressed in or linked to microglia and while activated microglia can clear a they also degrade neurons and synapses our knowledge on microglia function mainly stems from rodent studies which show microglia can target synapses via complement molecules or fractalkine but we do not know exactly which proteins mediate this contact how this translates to humans and how this is affected in adi hypothesize that microglia use different cell surface proteins to interact with synapses in ad compared to a healthy brain by combining several cuttingedge technologies i can now test this hypothesis in living human microglia i will transplant human ipscderived microglial progenitors into the cortex of healthy and appnlgf mice to ensure the microglia develop a transcriptional and morphological state like human in vivo microglia expertise of the mancuso lab using turboid proximity labeling and quantitative highresolution mass spectrometry i will tag extract and identify the proteins at the microgliasynapse interaction site and determine how they differ from the ad mouse model expertise of the de wit lab given that abnormal microglial function is linked to various neurodegenerative diseases my work will both provide valuable fundamental knowledge on microglialsynapse interactions and contribute to the development of new ad treatment targets
creating and stabilizing quantum resource phases of interacting quantum matter the equilibrium and nonequilibrium routes

we propose a program for creating and protecting quantum correlations and coherences responsible for the supremacy of quantum technologies by identifying their optimal embodiment in manybody states of quantum matter in and out of equilibrium our vision is to connect various stable phases of quantum matter especially the nonequilibrium ones with perturbatively connected families of resourceful states and thus tie the stability and creation of those phases with those of the resources our concrete formulation is based on physics insights of the symmetry localization property and dynamics of manybody systems under coherent external drivefor state creation we will employ quantum annealing based protocols combined with our understanding of quantum phasetransitions between simple phases eg ferromagnetic and those with useful correlations like longrange entanglement eg spin liquids the approach promises to evade notorious classical barriers for example the sign problems in simulating highly frustrated ground states without disorder can be bypassed by our protocol for protecting delicate quantum states we propose a novel approach of combining dynamical stability owing to the suppression of manybody chaos by a periodic drive and manybody localization our program will facilitate and expedite the advent of quantum technologies which are expected to revolutionize every aspect of human life and society on the fundamental side the project will uncover new territories in the field of quantum condensed matter especially that stabilized outofequilibrium this will initiate new research perspective to the field of theoretical manybody physics and endow the nascent field of nonequilibrium coherent quantum matter with a direct technological and hence economic relevance
frequency comb spectroscopy using specialty optical fibers

nonlinear fiber optics is paving the way for a new paradigm of technological developments especially in the domain of modern communication computation and metrology project frescos frequency comb spectroscopy with specialty optical fibers will utilize nonlinear optical effects in an interdisciplinary setting harnessing the untapped potential of specially designed optical fibers for developing a simplearchitecture allfiber multicomb spectroscopy setup this innovative and breakthrough technology will be used to perfrom dual and tricomb spectroscopy for precise and rapid chemical sensing as well as the study of transient nonlinear response of samples in the 15 micron wavelength that are inaccessible to linear spectroscopic techniques the required nonlinear specialty optical fibers like tricore fiber trimode fiber polarization maintaining fiber with and without twisting and dispersion compensating fiber will be designed and fabricated during the project in the fiber fabrication facility fibertech lille at the host institute project frescos will capitalize on a unique blend of scientific disciplines starting from fiber fabrication nonlinear optics chemical physics to spectroscopy to achieve a milestone in the science of precision spectroscopy and generate results to deepen our understanding of the fundamental physics of energy levels in chemical molecules
projecting the gdr on screen film festivals and cultural diplomacy in cold war germany

this project explores how the german democratic republic used film festivals in the west as a form of cultural diplomacy between 1949 and 1989 for the first time in scholarship this project considers the different ways in which governments artistic bodies and individuals viewed the opportunities of the berlin film festival the cannes film festival and the venice film festival as ways for the gdr to achieve cultural prestige and political capital in the west instead of presenting cultural diplomacy as a topdown process instigated and tightly controlled by state officials this research foregrounds the roles of artistic institutions filmmakers and festival organisers in establishing lines of communication inbetween and outside of formal channels the significance of this extends beyond the cold war by focusing on the role of state and nonstate actors the research allows for better understandings of how cultural events can be used to transcend political impasses today and in so doing also speaks directly to the european commissions new european agenda for cultureled by an outstanding researcher with a proven publication record this project will allow dr ward to develop further the core research training and professional skills needed as leading international academic in the humanities and emerge as an independent researcher by working with sectorleading cultural historians at leipzig university dr ward will hone her specialist research skills and undertake a targeted training programme to equip her with key research and professional skills needed to excel in academia these skills will be complemented by a carefully designed communication and dissemination strategy to ensure that upon completion of the fellowship she has the key markers of academic success publications interdisciplinary collaboration the organisation of an international workshop and public engagement public film screenings publishing for nonspecialist audiences
60hz light entrainment to unlock mental health conditions

mental health problems are a critical and everincreasing burden to society psychiatric medications aim to adjust imbalances in synapse signaling but often have only moderatetoweak efficacy psychiatric medications aim to adjust imbalance in synapse signaling but often have only moderatetoweak efficacy the main challenge is that certain neuronal infrastructures for cognitive and emotional skills are secured with a rigid extracellular matrix known as the perineuronal net pnn that forms around neurons and locks the brain in a function state enzymatic interventions that can release the lock have been evaluated in mice but they are not appropriate for translating into human therapeutics because they are invasive and prevent the reformation of pnn making the brain vulnerable in the context of the erc stg we discovered that noninvasive external light entrainment at highlyselective 60hz enables microglia localized within the neuronal network to transiently remove pnn in a controlled and brain regionspecific manner in both sexes with improved cognitive performances in mice thus our discovery solves the urgent need for a targeted noninvasive nonpharmacological therefore environmentalfriendly therapeutic intervention this erc proofofconcept will allow us to expand on our discovery and evaluate the therapeutic potential in a preclinical mouse model of anxiety disorder posttraumatic stress disorder ptsd our objectives are to identify at which stage of the fear memory formation 60hz entrainment shows the highest benefit adjust treatment length and repetition frequency and validate physiological parameters as a therapeutic success criterium these insights will refine the first prototype development and set the therapeutic frame which will both be critical to smoothen the transition into a clinical study posterc poc and will set the foundation for a spinoff company
a new understanding of the uplift and incision of the colorado plateau from classical and electron spin resonance thermochronology

highstanding orogenic plateaus are key features of most mountainous regions and typically have profound regional and in many cases global impacts on atmospheric circulation and precipitation patterns the colorado plateau is characterized by a lowrelief surface at high elevation and deep canyon incision at the plateau margins although these canyons are key features of ecosystems and water resources the chronology of the uplift and subsequent canyon incision remains debated in addition the relative importance of deepseated processes changes in paleogeography and climate on the late geomorphologic evolution of the plateau remains controversial two endmember models of grand canyon incision have been proposed a 8060 ma incision or a 65 ma incision the discrepancy between these models is partly related to limitations in conventional thermochronology techniques this project will provide new constraints on the incision history of the canyons carved across the colorado plateau using an innovative set of thermochronometers i will combine apatite uthsmhe and fissiontrack data to document the thermal history of rocks in zion canyon which has never been explored and infer the respective effects of erosion and regional magmatism on the thermal evolution of the lithosphere electron spin resonance esr thermochronometry a new thermochronometer sensitive to temperature ranging from 50 to 20c will be performed on the same samples and combined with thermokinematic modelling to decipher the timing and rate of canyon incision in zion finally i will apply esr thermochronometry in selected canyons to decipher the timing of incision across the colorado plateau lowtemperature thermochronology data including esr will be integrated in a numerical model of the landscape evolution to test different processes change in base level versus mantellic process and associated scenarios for the colorado plateau uplift and incision
sustainable covid19 vaccination for longterm vaccine immunity and effectiveness

despite the rapid development of various sarscov2 vaccines the control of the pandemic is hampered by the constant emergence of sarscov2 variants escaping vaccineinduced immunity and the waning of immunity solve will tackle these challenges by deciphering the mechanisms of induction of longlasting immunity and evaluating new vaccine platforms to achieve this goal an integrated plan has been developed including six pillars 1 vaccine discovery and design 2 headtohead evaluation of the immune response and longlasting immunity induced by four vaccine platforms in the preclinical setting 3 validation of the preclinical results in an experimental medicine trial emt 4 immune mechanisms of longlasting immunity 5 data science 6 determinants of population adherence to vaccination new immunogens including key mutations from most recent variants in rbd and nucleocapsid sequences highly conserved across sarbecoviruses will be delivered through antigentargeting to dendritic cells dc ie cd40 dctargeting nanoparticles a mva vector and 2nd generations of mrnas solve will evaluate in depth the immunogenicity of these vaccines in the preclinical setting and in an emt testing two vaccines ie cd40 dctargeting and mva with available gmp clinical lots solve will benefit from the most advanced technologies to identify the mechanisms of longlasting immunity integrative analyses of high throughput data including from large cohorts will provide insights for identification of factors demographics vaccines immunity which impact quality and longevity of immunity solve will investigate stakeholderss perspective on the acceptability of large vaccination campaigns to improve implementation of next generation of vaccines in a preparedness track the consortium gathers 8 renowned publicprivate institutions supported by a governance facilitating fast sharing of information to keep up with a tight schedule imposed by the pandemic
the cost of uncertaincy a study on the reform of the european commissions leniency program

this project will study the improvement in effectiveness of the european commissions leniency program in cartel detection post the 2002 reform which improved the programs transparency and reduced its uncertainty specifically i aim to quantify the increase in number of leniency applications attributed to the feature of automatic amnesty using a structural approach in addition i am interested in finding out how firms with different characteristics such as sizes industries compositions of management and board respond differently to the reduction in uncertainty the main objectives of the project include deepening the understanding of firms behaviors under uncertainty bringing forth methodological innovations informing on policy making and raising awareness of the general public to achieve these objectives i will employ innovative approaches that are multidisciplinary and go beyond the state of the art while paying special attention to the of gender i will actively engage in supervision and training provided by my host institution construct and refine the theoretical model and empirical strategy in a timely manner disseminate the research idea and findings through a professional network that i will actively expand and engage with a broader audience outside of academia including policymakers business leaders and the general publicin the process of achieving these objectives i will acquire and improve skills in technical aspects of economics research data management and research management i will also expand my professional network improve domain translational expertise which will enhance my career prospects in academia the private and public sectors
emulating complex causal socioecological models in digital twins of ocean

to fully realise the potential of the european digital twin ocean dto to empower citizens entrepreneurs scientists and policymakers with accessible knowledge about ocean and coastal domains new models tools and methods are needed to understand and assess the complex interactions of social economic and ecological factors ecotwin delivers innovative graph theoretic solutions developed using a multiactor approach with policy makers local communities marine and coastal industries and communities to address the challenges of modelling marine socioecological systems and integrating these models into the emerging dto framework innovations include four different classes of novel socioecological models based on concepts from mathematics graph theory control engineering stability computer science generative ai statistics bayesian theory and information science entropy combined with dynamic participatory feedback from stakeholders and methodological protocols enabling seamless integration with dtos by accounting for the interoperability accessibility reliability and sustainability of transdisciplinary data the models comprise 1 quantitative causal graph theoretic models 2 qualitative causal graph theoretic models 3 network models with participatory feedback and 4 parallel generative ai models through validation in four use cases in the north sea belgium germany celtic sea ireland thracian sea greece and waterford harbour ireland tools will be developed for assessing scenarios including the relationships between factors including ecosystem services and health geopolitical factors fishing job losses tourism and marine renewables development results will enable whatif scenario analysis and impact assessments exploring the interconnected impacts of environmental changes human pressures and policy implementation to empower better decisionmaking to support ocean health social prosperity and a thriving blue economy