Dragon09/odtu_chatbot huggingface dataset:
biointegrable soft actuators alimented by metabolic energy

stateofthe art implantable actuating devices such as automated prosthetics have timelimited operational capacities because they are sustained by batteries which ultimately rely on external power sources to be recharged integrate proposes a radically new way to solve this problem use metabolic energy from the patient to power implanted devices to achieve this ambitious goal integrate will develop i new 3d printable soft actuating materials inspired by human muscles whit high performances and low power consumption and ii an artificial organ capable of harvesting metabolic biochemical energy and transform it into electricity the actuating materials bionic muscles will be prepared via selfassembly of biocompatible colloidal liquid crystals and stimuliresponsive polymers a modular design and 3d printability will offer the possibility to manufacture these materials on the basis of patients anatomy and needs the energyharvesting organ will be capable of converting ph differences within various body fluids eg gastric juice and saliva in electricity with high efficiency providing the necessary power to sustain the bionic muscles this research will revolutionize the field of implantable devices and will represent a turning point in robotics wearable technologies materials science energy conversion and materials engineering
single cell rnaseq analysis of individual sperm cells to identify transcriptomic differences potentially involved in preferential fertilization

human societies are sustained by flowering plants in different ways but especially as a key food supplier however it is known that increasing global temperatures strongly affect plant reproduction and the growing human population will require more food in shortmiddle term thus to create new crop varieties more resistant to heat stress and with enhanced yield a deeper understanding of the mechanism of plant sexual reproduction will be crucial for increasing the efficiency of plant breeding programs plant reproduction relies on a double fertilization process in which two sperm cells from a pollen grain reach the ovule and one fertilize the egg cell while the other the central cell in some species with dimorphic sperm cells a preferential fertilization of each sperm cell has been described but for arabidopsis thaliana as well as for many economically important crops with isomorphic sperm cells this question remains unclear the main goal of this project is to identify by single cell rnaseq analysis potential transcriptomic differences between the two arabidopsis sperm cells to do that individual sperm cells from pollen tubes growing through female stylar transmitting tissue semi in vivo will be isolated by micromanipulation using a specially designed microfluidic chamber on an inverted microscope the identification of differentially expressed genes would enable for the first time the creation of a sperm singlecell marker line to eventually explore a hypothetical preferential fertilization in arabidopsis these results can be adapted for plant breeding programs to develop impactful biotechnological tools like haploid inducer lines with genetically modified sperm cells to specifically deliver components in the egg cell to induce in vivo gynogenesis additionally the results will be a valuable scientific resource to address other topics beyond the preferential fertilization like exploring hybridization barriers based on gamete recognition
argument asymmetries revisited variation in parallelism constraints on atbmovement

the proposed project involves dr andrew murphy the university of chicago as the researcher and prof dr doreen georgi university of potsdam as the supervisor the project title is argument asymmetries revisited variation in parallelism constraints on atbmovement this project will investigate the phenomenon of parallelism conditions in socalled acrosstheboard dependencies on the empirical side the project aims to broaden the empirical base through a comparative study of tolerable mismatches between argument types in atbconstructions on the basis of three languages english german polish that also takes into account the role of variation on the theoretical side the project will incorporate these findings into a general theory of crosslinguistic argument asymmetries involving movement a goal which has not yet been seriously pursued in contemporary syntactic research
sediment transport and morphodynamics in marine and coastal waters with engineering solutions

coastal and estuarine areas are under constant erosionsedimentation pressure the sustainable development of these areas depends on our understanding of and ability to predict the effect of complex sediment transport and morphodynamic processes and the development of effective applied engineering solutions coastal protection is an important issue in the implementation of successful integrated coastal zone management iczm plans the objective of the intrersectoral network sedimare is the interdisciplinary training and award of a phd degree to researchers in coastal processes and engineering aiming towards a sustainable coastal use and protection the network comprises 5 university beneficiaries 3 private sector beneficiaries 1 applied research institute 1 corporation and 1 sme and 3 associated partner 1 university and 2 industrial ones the network will provide a trainingthroughresearch program to 12 doctoral candidates which comprises comprehensive academic training including webbased teaching interinstitutional cosupervision intersectoral secondments summerwinter schools workshops complementary activities dissemination and outreach activities the research plan is organized into 3 work packages wp 1 sediment transport processes 2 coupling of flow sediment transport and morphodynamics and 3 sustainable coastal engineering solutions each wp includes several projects whose implementation is based on the strong interaction between all beneficiaries the topics include complex sediment transport processes involving sandmud mixtures mixedsize sands and granularfluid mixtures coupling between hydrodynamics waves storm surges and tides sediment transport and morphological changes and engineering solutions to issuesproblems related to erosionsedimentation with emphasis on sustainability and resilience the research methods include effective processbased engineering modeling advanced numerical simulations and innovative experiments
aicode ai services for continuous trust in emerging digital environments

the media sector is exposed to and undergoing continuous innovations that occur at a pace never seen before and have a nonnegligible impact on citizens democracy and a society as whole a significant booster becomes a generative artificial intelligence which already plays and will continue to play a critical role in a positive as well as negative meaning in creating and spreading information especially in nextgeneration social media which refer to the anticipated evolution towards more aibased decentralised and immersive virtual environments like fediverses and metaverses generative ai can become the most prominent enabler of disinformation growth accompanied by a lack of trusted information media professionals are not however currently wellequipped with supporting tools nor knowledge to operate in such already emerging environmentsas a result there is a tremendous need for innovative aibased solutions ensuring media freedom and pluralism delivering credible and truthful information as well as combating highly disinformative content the main goal of the aicode project is to evolve stateoftheart research results tools technologies and knowhow from the past and ongoing eufunded research projects focused on disinformation to a novel ecosystem of services that will proactively support media professionals in trusted information production through ai first the project aims to identify analyse and understand future developments of nextgeneration social media in the context of rapid development of generative artificial intelligence and how such a combination can impact the disinformation space second the project aims to provide media professionals with novel aibased services to coach them how to work in emerging digital environments and how to utilise generative ai effectively and credibly to detect new forms of content manipulation as well as to assess the reputation and credibility of sources and their content
inverting glucosidase inhibitors as potential drugs for sarscov2

viral infections are still a major challenge in medical therapy the recent outbreak of sarscov2 has again shown the immense threat these pathogens pose in contrast to the directacting antivirals approach targeting viral proteases polymerases or other viral enzymes involved in replication which is mostly followed by the pharmaceutical industry this proposal targeting host cell enzymes involved in the biogenesis of infectious virions in this context inverting glucosidases are of special interest they play an important role in cell functions such as the correct folding of proteins in the endoplasmic reticulum er however up to now selective inverting glucosidase inhibitors are scarce and chemical probes that report on these selectively in biological samples nonexistent the dedicated aim of this proposal is to overcome this absence of inhibitors and probesto identify novel inhibitors activitybased protein profiling abpp will be applied this powerful analytical method is a driving force in chemical biology and medicinal chemistry but depends heavily on the availability of mechanismbased enzyme inhibitors based on current knowledge on retaining glucosidase inhibitors unprecedented inhibitors and probes for inverting glucosidases will be developed and applied to abpp their synthesis follows a divergent synthesis method to efficiently produce a wide library of compounds that will be screened on the target enzyme human er glucosidase i as the work on retaining glycosidase has shown inverting glucosidase inhibitors are likely to be important tools for advancing many areas of application that are outside the primary scope of the proposed research antiviral agents overall my proposal on inverting glycosidase inhibitors and probes will therefore make a significant contribution to the current state of the art in glycan research
biological microswimmers for cargo delivery systems modelling simulations and experiments

bacteria protozoa and microalgae have evolved mechanisms to selfpropel the interactions between different types of biological microswimmers bm are relevant in natural processes such as the regulation of carbon and oxygen biogeochemical cycles and the toxin releasing by phytoplankton blooms under certain environmental conditions but also in development of technological applications due to the emergence of a collective behaviour and a spatiotemporal synchronization bm have been used as transporters showing promising results at carrying and releasing a cargo in a specified target however there is still a lack of sharp control of the collective movement of bm towards a target which implies a poor delivery of the cargo at the desired place this flaw comes from the fact that in real scenarios bm swim through complex porous media where interact with passive and active agents and are subjected to external fields such as light concentration of chemicals and global background flow that highly affect their motion and hinders its predictability up to date the concomitant effects of confinement external fields and interactions with other bm or active agents have not been taken into account in current simulations or experiments the proposed action therefore aims to develop a new computational approach that enables simulation of suspensions of interacting bm in complex confined environments at the same time subjected to external fields providing a platform to gain fundamental knowledge on the control of the collective behaviour of mixtures of bm under conditions compatible with the conceptual design of efficient cargo delivery systems the simulation platform will be feedbacked and tested with experiments in which suspensions containing phototactic c reinhardtii and chemotactic e coli bm will be studied with microfluidics
2d nonvan der waals bimetallic transition metal chalcogenides for magnesiumion energy storage

magnesiumion batteries mibs present compelling performance and sustainability attributes while sharing common manufacturing techniques with lithiumion batteries thus enabling rapid commercialization however challenges remain to be addressed such as low capacity and poor cycling stability of the cathode materials stemming from sluggish mg2 diffusion kinetics dendrite growth and irreversible mg platingstripping of the mg metal anode especially when operating in noncorrosive electrolytes in response to these challenges bimion project leverages the expanding toolbox of 2d nonvan der waals nvdw bimetallic transition metal chalcogenides btmcs and hybrids thereof with functionalized conductive graphene derivatives as potential cathode materials for mibs the 2d engineered nvdw btmcs will be utilized to boost the mgion diffusion and by leveraging metalmetal cooperativity in these structures bimion aims to ascribe stable redox cycles and boost the stored energy importantly tailored graphene derivatives with dense outofplane functionalities can facilitate the formation of covalent hybrids with 2d nvdw btmcs ascribing improved charge transport and stability of the resulting heterostructured electrodes ultimately enabling longterm cyclability of mibs the mg metal anode will be engineered by applying heteroatom doped graphene structures adorned with single metal atoms at the surface to improve the mgnucleation and magnesiophilicity to impede the irreversible mg platingstripping in noncorrosive electrolytes the bimion project aims to revolutionizing energy storage based on safer abundant environmentally friendly and costeffective solutions thereby reducing our reliance on lithiumbased technologies and accelerate the transition to sustainable energy sources
molecular quantum dynamics in low temperature condensed phase astrochemistry

the james webb space telescope jwst has ushered in a new era in observational astrochemistry jwsts ability to obtain infrared spectra of molecular ices condensed on interstellar dust grains in dense starforming clouds and in protoplanetary disks is expected to revolutionize the field since these ices are known to be important sources of complex organic molecules on a fundamental level the physicochemical behavior of these ices obeys the laws of molecular quantum dynamics occurring in lowtemperature condensed phases this is a forefront research area in chemical physics that unfortunately remains poorly understood this project establishes an interdisciplinary synergistic research consortium to address this knowledge deficit bringing together the unique expertise of the groups of alec wodtke chemical physics at surfaces liv hornekr astrochemistry and scanning tunneling microscopy and peter saalfrank theoretical quantum dynamics under irastro we will develop and employ advanced infrared technology based on superconducting nanowire singlephoton detectors snspds for new experimental capability in laboratory experiments directly relevant to astrochemistry we will combine megapixel snspd arrays with chelle spectrometers enabling solidstate midinfrared emission spectroscopy including singlemolecule midir spectroscopy in a scanning tunneling microscope with these new experiments and forefront quantum theory we will tackle three research themes 1 infrared spectra of molecules on surfaces under interstellar conditions 2 energy dissipation channels on low temperature surfaces and 3 chemical reactivity under interstellar conditions irastros focus on ir spectroscopy will make the projects findings directly relevant to the interpretation of jwst observational data and through a fruitful collaboration of experiment and theory provide a better fundamental understanding of astrochemistry
chemoenzymatic processing of biobased building blocks to circular functional materials

recent advances driven by the societys need of implementing a more sustainable polymer chemistry led to the development of several biobased materials and the booming of the interest of using biocatalysts for polymer processing and recyclingthe aim of circularize is to develop appropriate chemoenzymatic methods to process biobased resources to obtain advanced functional materials via the exploitation of highly selective reactions following the green chemistry principles further the aim is based on that knowledge to improve the reaction efficiency of the biocatalysts and understand and control the surface and bulk properties of the produced materials in pursuit of novel smart materials and reactive surfacescurrent processes for the utilization of biobased monomers and resources are unspecific and lead to products in poor quality due to side reactions specific biocatalysts could achieve optimal selectivity together with minimal damage to the monomers and polymers and provide highquality advanced materialswhen considering the multifunctional monomers deriving from biomass the chemo catalytic techniques used by industry have some major shortcomings such as limited selectivity leading to side reactions and use of toxic catalysts and solvents using this knowledge the circularize project will develop and apply techniques based on sustainable chemoenzymatic processes developing a series of fully biobased hybrid polymers having smart characteristics temperatureswitchable vitrimeric properties while being able to finely tune their degradation via the insertion of enzymesusceptible motifs methodologically circularize strives to establish new approaches at the crosssectorial biotechnologypolymer chemistry interface to extend the current knowledge on enzymes for polymer synthesis and processing and in the long term the development of a sustainable biopolymer chemistry able to build an endless selective carbon recovery loop
the role of symbiont diversity in resilience to temperature fluctuations

beneficial microbes are essential for many animals and mutualistic interactions must be able to withstand environmental changes such as temperature fluctuations however with changing ocean temperatures induced by climate change it is unclear whether symbioses will be able to adapt leaving marine organisms at risk therefore this proposal will characterize how bacterial symbionts respond to changing temperatures and identify whether microbes can increase symbiotic resiliency to temperature stress to pursue this topic the symbiosis between the squid sepiola affinis and its symbionts v fischeri and v logei will be used the project uses a unique squid husbandry facility to pursue three main objectives the first objective will characterize initial and persistent colonization in the s affinis light organ using confocal microscopy and genetic labelling strain behaviors during colonization will be described the second objective will examine how temperature affects colonization the third objective will screen vibrio spp for growth under temperature fluctuations rna sequencing and metabolomics will be used to identify molecular mechanisms underlying resilience to temperature fluctuations finally genetic modification and both invitro and invivo growth assays will test whether molecular candidates promote temperature resilience the project will have a twoway transfer of knowledge with the researcher providing knowledge of vibrio spp and bacterial genetics with the host institution providing bioinformatics and small molecule analysis the symflux project will position s affinis as a model for symbiosis research in europe as well as contribute knowledge of how symbioses can adapt to climate change
biomolecular condensates and coacervates from medicine to agriculture

biococomer will pursue three general objectives researchinnovation training and international collaboration that will be achieved through the development of new skills and products and exchange of multidisciplinary and complementary knowledge and competences within the international partners from italy australia portugal spain cuba switzerland germany and south korea research and innovation objectives objective 1 engineering and characterising biomolecular functional condensates and coacervatesobjective 2 understanding the behavior of the bioactive coacervates in cellular environments objective 3 application of coacervates in gene editing of recalcitrant plantstowards innovative tools for gene delivery in organisms biococomer is focused on the design and engineering of innovative biomolecular condensatescoacervates using peptides proteins polysaccharide and nucleic acids as innovative tools for gene delivery in mammalian cells and plants through a combination of computerbased theoretical design and experimental and characterization approaches biococomer is expected to generate a library of welldefined condensates and coacervates by programmed coassembly and phase separation of mixtures of biomacromolecules ie polysaccharideprotein polysaccharidepolyphenols peptidepeptide nucleic acidprotein the condensates and coacervates will be engineered to readily recruit rna and dna molecules during phase separation in aqueous solution and to be stimuli responsive to enable transfection of mammalian cells and plants scientific impact biococomer will ultimately result in significant scientific breakthroughs towards innovative universal transfection tools with widespread biomedical and biotechnological applications we intend to explore the potential of the developed platforms with the longterm aim of boosting the translational pathway of research in medicine and agriculture
molecular gated ecomofs for anticancer drug delivery

cancer is a major societal challenge as reflected by horizons europe mission on cancer and europes beating cancer plan in particular despite great advances in cancer treatment in recent decades its treatment still remains a challenge without an effective cure in 2020 the eu reported around 3 million new cancer cases and more than 12 million deaths and its incidence is expected to increase in europe due to its aging population the standard treatment relies on the systemic administration of chemotherapeutics which has limited efficacy and causes side effects to overcome current limitations gatemof will develop lowtoxicity molecular organic frameworks mofs as advanced nanosystems to tackle cancer such ecomofs will be equipped with molecular gates and loaded with anticancer drugs resulting in advanced biocompatible nanosystems with the ability to respond to stimuli present in the tumor intracellularmicroenvironment for a selective anticancer drug delivery the project combines the unique expertise of the host laboratory supramolecular chemistry and biotechnology and the candidate mof design and synthesis to ensure the fulfillment of objectives the fellow will be trained in advanced nanomaterial preparation with molecular gates to obtain stimuliresponsive mofs for anticancer drug delivery including training for biological studies for their evaluation in vitro in cells and in vivo in animal models notably the project will also allow the fellow to gain experience in patenting and tech transfer altogether gatemof will develop a new therapeutic technology and provide the fellow with complementary scientific and transferable skills with a significant impact toward an independent research career