Dragon09/odtu_chatbot huggingface dataset:
dynamic business continuity of critical infrastructures on top of adaptive multilevel cybersecurity

improving the ci capacities at preparedness detection and response phases requires the attention to the human factor as well as the collaboration of heterogeneous organisations involved in the ci development and operation ensuring a continuum of care just as it is done for other ict systems with the adoption of secdevops approaches dynabic consortium believes that the adoption of defensive ai and novel approaches to continuous business risk management based on enhanced secdevops can drastically improve critical services resilience furthermore aibased selfhealing and autonomous response automation can greatly help to achieve fast and efficient recovery and enable the provision of fully resilient critical services to european citizens the strategic objective of dynabic is to increase the resilience and business continuity capabilities of european critical services in the face of advanced cyberphysical threats this objective will be pursued by delivering new sociotechnical methods models and tools to support resilience through holistic business continuity risk management and control in operation and dynamic adaptation of responses at system human and organization planes dynabic will deliver the dynabic framework that will enable oes to predict quantitatively assess and mitigate in realtime business continuity risks and their potential cascading effects furthermore it will enable the dynamic autonomous adaptation of critical infrastructures to meet resilience goals by the automatic optimization and orchestration of response strategies the dynabic framework will be validated in two types of demonstrations i smart preparedness prevention and response to business disruption risks in 4 critical infrastructures and supply chains ev charging stations critical transport services telco services and hospital services and i smart preparedness and response to cascading business disruption risks in interconnected cis
graphene photonic frequency mixer

graphx aims at the development of a novel hardware platform based on graphene photonic integrated circuits for ultrahigh speed and scalable subthz d 110170 ghz and hband 170240 ghz wireless links the proposed technology will be the basic building block for highspeed radio back haul links multi beam forming antennas for massive mimo short distance high resolution radar sensing graphx targets the distribution and detection of multi gbits radio signals over subthz tunable carrier frequencies the main outcome of graphx will be a monolithic electronic and photonic chip epic that will constitute the basic building block of a completely new class of photonicelectronic antenna arrays for the next generation subthz communication and radar systems the proposed approach will allow to overcome the technical bottlenecks of current subthz technology such as increasing detrimental effect of phase noise at higher carrier frequencies and carrier frequency stability to reach the goal the wafer scale graphene photonic technology is needed and must go beyond the state of the art a new technique hmgstack technology will be developed to allow multistacking of graphene layers maintaining the same properties of single layer graphene the key component of graphx is a novel optoelectronic efficient frequency mixer able to mix two optical wavelengths and a high data rate electrical signal the photonic chip will be realized using a sin photonic platform that will integrate hmgstack as active material the monolithic integration of the graphene photonic mixer with sige bicmos electronics for mmwave amplification will enable high output power and reduced footprint 500x500m2 matching the requirements of a single element of mmwave antenna array system
revealing the structure and mechanism of mitotic chromosome folding inside the cell

mitosis is a fundamental biological process every cell undergoes at least once it requires a dynamic and dramatic restructuring of the genome from extended interphase chromatin to compact individual mitotic chromosomes capable of faithful segregation altered nucleosome interactions phase separation and loop extrusion have all been proposed to play important roles in shaping mitotic chromosomes however what the internal architecture of single mitotic chromosomes is and how this architecture is established in space and time by different forces inside the cell remains unclear this lack of knowledge precludes a comprehensive mechanistic understanding of mitotic chromosome folding and unfolding this project aims to resolve the folding principles of chromosomes during mitotic compaction and decompaction in situ in single human cells to achieve this we will combine newly developed nanoscale dna tracing technology with quantitative single protein imaging approaches to achieve a systematic structural analysis of mitotic chromosome folding throughout mitosis we will investigate when and where which structural features are first established and then use targeted acute perturbations to dissect which regulators are required to form and maintain them the resulting data will provide an in situ structurebased model to explain the essential function of the genome in mitosis and will allow us to understand the spatiotemporal coordination of the underlying molecular and physical mechanisms overall the proposed project will provide a new framework for understanding the physiological and pathological roles of mitotic chromosome restructuring during cell division
vehicles and vru virtual evaluation of road safety

in order to set policies for road safety in the coming decades and push for vision zero an accepted and reliable method for the comparison of safety measures for ccam is needed the proposed method will deal with the safety of all road users from vulnerable road users to vehicle occupants v4safety will provide a prospective safety assessment framework that can handle a large variety of safety measures ranging from invehicle safety technology new vehicle types infrastructure solutions to regulations that influence road user behaviour it includes methods to project the results in future scenarios and over eu regions for use by policy makers authorities and consumer organizationsv4safety strives for comparability of results of safety studies by not only providing the framework but also guidelines for using it the guidelines show how to select configure and connect relevant human vehicle and environment models how to select a baseline approach and how to project to a conclusion to different regions of interest in the eu moreover the framework will also allow projections for future scenarios incorporating possible changes in the mobility systemto understand differences between studies and to understand the influence of underlying data assumptions and models the method provides tools to characterise the influence of the determinantscombined with a welldefined baseline approach what to compare to the resulting transparency and consistency in simulationbased safety assessment leads to much improved comparability and reliability of assessment conclusions
sustained concerns administration of mineral resources in central europe 15501850

early modern mining often played out as a drama in three acts i ores are discovered ii communities flourish iii the mines collapse across central europe however this drama took an unusual turn emerging territorial states stepped in to reorganise the sector and suspended the collapse of mining for years decades and centuriesunderstanding why and how stateemployed administrators prolonged the lifespan of mines has great potential to advance debates in economic history history of science and technology and environmental history the principal aim of this project is to open up the history of resource management as a field of study whose questions and results are equally well integrated in these three fields it will use central european mining as a highstakes case to prove the viability of such a history by doing so it will provide1 a new account of capitalist development by showing how an industry in seemingly underdeveloped central europe shaped two important building blocks of modern economies the rationalisation of labour and the accumulation of capital2 a new understanding of technoscientific innovation in protoindustrial settings by showing how administrative procedures accounting reporting shaped scientiststechnicians understanding of natural processes3 a new genealogy for modern sustainability by focusing attention on the contradictions that shaped the extraction of nonrenewable resourcesto achieve these aims four researchers 1 pi 1 postdoc 2 phd will analyse thousands of administrative reports from across central europe using a new method history of bureaucratic knowledge based on recent advances in the history of science they will work on four processes through which administrators made mining a longterm enterprise a rationalising labour b managing health and pollution c sustaining investment and d longterm planning
the dynamic structure of protein domains within the cytoplasmic membrane of escherichia coli

membrane proteins govern how bacteria inside the human body animals plants water sources or soil interact with their environment membrane proteins show intricate spatial organization and can be compartmentalized in the membrane but it is unknown how they dynamically assemble and vanish from membrane domains in this project i aim to reveal the dynamic organization of membrane protein domains in the inner membrane of escherichia coli i will examine the distribution and dynamics of proteins that engage in protein domains and play crucial roles in the distribution of other proteins in the membrane these proteins are responsible for functions like membrane protein translocation quality control lipid raft formation and synthesis of the peptidoglycan scaffold by employing livecell superresolution and singlemolecule fluorescence imaging i will observe the assembly movement and variations in size and content of protein domains within growing bacterial cells i will investigate the impact of external conditions like heat and osmotic stress starvation and antibiotics on the dynamics of membrane protein domains this proposal addresses a fundamental gap in our understanding of the organization of proteins in bacterial membranes and thus offers insights into various processes from chemotaxis to pathogenhost interactions the development of superresolution fluorescence microscopy protocols for imaging membrane proteins in live bacterial cells will be a methodological achievement enabling further advancements in the field
focused targeting of inhaled magnetic aerosols for lung cancer

the pulmonary tract is an attractive route for direct treatments of lung diseases yet our ability to confine the deposition of inhalation aerosols to specific lung regions and notably local airways remains still widely beyond reach with common inhalation therapy it has been hypothesized that by coupling magnetic particles to inhaled therapeutics the ability to locally target airway sites can be substantially improved yet virtually all practical implementations to date have come short of delivering efficient localized airway targeting here we demonstrate an engineered inhalation framework to leverage magneticallyloaded aerosols for airway targeting in the presence of a customdesigned external magnetic field by coupling the delivery of a short pulsed bolus of submicron 500 nm diameter droplet aerosols laden with superparamagnetic iron oxide nanoparticles spion with a custom ventilation machine that tracks the volume of air inhaled past the bolus focused targeting can be maximized during a breathhold manoeuvre our aerosol inhalation platform allows for the first time to deposit inhaled particles to specific airway sites while minimizing superfluous deposition across the respiratory track this represents a dramatic effort to augment the targeting efficiency ie deposition ratio between targeted and untargeted aerosols our first application of focus is aimed at lung cancer we aim to achieve point targeted delivery of chemotherapeutics directly to lung tumours and lesions through inhalation thus increasing effective doses and dramatically reducing side effects in particular relative to detrimental systemic toxicity aerotarg embodies a significant paradigm shift in drug delivery modalities aimed for lung cancer therapy
nanomaterialaided enhancement for psychrophilic anaerobic membrane bioreactor for sustainable bioenergy recovery from organic waste

in response to climate change the eu has pledged to reduce net ghg emissions by 55 by 2030 and achieve carbon neutrality by 2050 a primary strategy to achieve these ambitious climate and energy goals is the transition from fossil fuels to renewable energy sources biogas production through anaerobic digestion ad of organic waste such as livestock waste plays a crucial role in europes move towards sustainability owing to the high energy input required for mesophilic or thermophilic ad in cold regions psychrophilic ad has emerged as a promising biotechnology for treating specific livestock wastes eg pig manure or pm and recovering bioenergy in these climateshowever psychrophilic ad still confronts significant challenges in treating pm including i inefficiencies in methane production due to diminished microbial activity at low temperatures ii slow growth and susceptibility of methanogenic consortia to washout and iii the adverse effects of antibiotics present in pm on microbial activity the eufunded nano4panmbr project seeks to develop a cuttingedge and viable psychrophilic ad technology by integrating nanomaterials and membrane bioreactor technologies to boost renewable bioenergy production this goal will be accomplished through the following research objectives 1 synthesizing and screening nanomaterials to enhance psychrophilic ad of pm 2 evaluating the performance of the psychrophilic anmbr in treating pm using the selected nanomaterials 3 investigating methods to mitigate membrane foulingthis project is profoundly interdisciplinary incorporating tools approaches and expertise from the engineering microbiology nanotechnology and membrane technology fields the participating researcher will receive comprehensive training in both scientific and broader skills activities for dissemination communication and exploitation have been planned to engage a wide range of audiences
clinical trials community africa network

with over 25 of the global disease burden only 3 of global clinical trials occur in africa this disproportion is driven by inadequacies in clinical research capacity regulatory process ambiguity deficient regional patient and disease area data and lack of visibility of existing clinical research capabilities in africa to address this disproportion this proposal seeks to establish the clinical trials community africa network ctcan a collaborative framework of key clinical research stakeholders in the african region pharma partners and other relevant international stakeholders with the overarching goal of bringing more clinical trials to the region in a sustainable and coordinated manner this collaboration will map and draw on the experience and expertise of already existing networks and initiatives it will create a network of subnetworks that will foster coordination in clinical research by ensuring and encouraging alignment in disease area prioritization raising awareness and visibility of existing capacity from sites and labs across africa operationalising the regulatory processes across the region and strengthen less experienced sites and labs through a clinical trial preparedness framework while encouraging inter and crosscontinental knowledge and expertise sharing ctcan will use and expand the clinical trials community ctc platform an electronic platform consolidating data on researchers regulations sites and epidemiology across the continent the result will be an everpresent and readytogo pool of clinical research sites and labs with the agility to rapidly address new and emerging global health threats epidemics and pandemics thereby efficiently contributing towards clinical research in pandemic preparedness ctcan will lay the foundation for a sustainable network of clinical trial sites and laboratories in subsaharan africa by leveraging and initiating collaboration between existing subnetworks funders and pharma
scaling social entrepreneurship and innovation zooming in on multidisciplinary interconnected challenges

the seizmic doctoral network represents an ambitious endeavor to catalyze scalable social entrepreneurship se across europe addressing a critical gap in the social entrepreneurship landscape seizmic aims to unravel the complex dynamics of scaling social enterprises focusing on external replication and imitation to magnify societal impact this project is particularly pertinent given the noted scarcity of se scaling a phenomenon that limits the societal reach of innovative solutions at the core of seizmics mission is the development of an interdisciplinary and crosssectorial research framework the network harnesses expertise from diverse fields such as entrepreneurship finance education and technology management aiming to synthesize these into a cohesive theoretical framework this integrative approach is designed to overcome entrenched interdisciplinary barriers and equip a new generation of researchers with the competencies necessary for advancing se scaling the research program is structured around five key work packages wps each addressing a distinct aspect of se scaling social business model design wp2 impact investing for se scaling wp3 competencies and education for se scaling wp4 and the role of digital ecosystems and ai in se scaling wp5 these wps involve innovative methodologies including case studies surveys aidriven mentoring and digital transformation analyses ensuring a comprehensive exploration of se scaling
synthesis of biobased and biodegradable polymers from monomers from renewable biowastes via biocatalysis and green chemistry to contribute to european circular bioeconomy

polymers5b aims to develop novel alternative biobased polymers synthesized from biobased monomers diacids diols diamines hydroxyacids aminoacids aromatic and phenolic compounds fatty acids oils furans sourced from underexploited second generation 2g feedstocks such as agrifood waste tomato and olive wastes and biomass wood pulp and lignin derivatives obeying the food first and cascading principle the project will resort to biocatalysis and green chemistry processes to generate novel biobased polymers like polyesters and polyamides with pendent functional groups eg hydroxy carboxylic amine epoxy thiol others polyphenols and polyfurans that mimic fossilbased polymers properties eg polyethene terephthalatepet polyurethanespus acrylonitrile butadiene styreneabs amine and other polymeric resins targeting improved biodegradability these new polymers will be blended to provide valuable biocomposites and polymeric materials for the textile automotive furniture and polymeric resin markets machine learning ml tools will drive the optimization of the developed technologies towards minimum resource usage zero waste and zero pollution while technological economic and environmental sustainability aspects will be incorporated early in the design phase by adopting sustainable by design ssbd approaches this sustainable strategy will contribute to an increase in the availability of monomers biobased polymers plastic materials synthesized in the eu that meet the green deal targets reducing the carbon footprint and dependency on fossilbased raw materials and derivatives
defining an integrated model of the neural processing of speech in light of its multiscale dynamics

this interdisciplinary project will define an integrated model of speech processing by recording modelling and manipulating neural oscillatory dynamics during perception of speech defined as a multiscale temporal signal dominant models of speech perception describe its underlying neural mechanisms at a static neuroanatomical level neglecting the cognitive algorithmic and neural dynamic levels of description these latter can only be investigated by considering the temporal dimension of speech which is structured according to a hierarchy of linguistic timescales phoneme syllable word phrase recent advances in behavioural paradigms computational modelling and neuroimaging data analysis make it now possible to investigate the cognitive algorithms and neural dynamics subtending the processing of speech to define an integrated model of speech perception this project seeks to 1 record neural activity in humans with magnetoencephalography and intracranial recordings during perception of continuous speech 2 quantify linguistic information at each timescale of speech with a computational model and 3 estimate their respective and shared neural correlates with multivariate and directed connectivity analyses feasibility is ensured by an inhouse access to neuroimaging and intracranial recordings as exemplified in the data on figure 1 of this proposal this project will critically test whether neural oscillations play a fundamental role in the computational processes of perception and cognition it will define the mapping between speech and neural timescales and reveal how information is transferred and combined along the linguistic computational processing hierarchy it will overall specify in terms of the nature of the information processed and of the dynamical hierarchical organization the respective contributions of left and right hemispheric ventral and dorsal auditory pathways in speech processing
real time high sensitive food allergen sensor

food allergies affect around 26 million of europeans and 32 million of americans the severity of the allergic reaction may vary from less severe symptoms such as hives and digestive problems to a quickly progressing and potentially lifethreatening anaphylactic shock nowadays food allergy is an incurable condition so the most important preventive measure is the complete abstinence from the allergen existing allergen detection methods are slow cumbersome costly and most of them are limited to work in a lab environmentthe resas projects goal is to fabricate a device able to sense extremely low concentrations of food allergens within minutes this is achieved by combining an ultrahigh sensitive biosensor substrate an integrated optical transducer and an electrical signal processing unit the proposed kind of sensor on the basis of integrated optics enables small size 5 cm3 high repeatability and instant response as well as potentially lowcost and mass production this is achieved thanks to the rof technology and the signal analysis of the output laser of the spr in the electrical domain which reduces instrumentation demands with instant allergen detection and great biosensing sensitivity furthermore the resas device has a removable biosensing substrate that can be replaced after use allowing users to operate resas several times and for as many types of food allergens as needed this approach of interchangeable biosubstrates tackles one of the major limitations of most current biosensing technologies which can be used only once and are restricted to one type of food allergenthe resas project will significantly impact the food industry as our food allergen testing method promises to be quick effective and inexpensive this may lead politicians to demand a more rigorous testing regime greatly improving food safety finally a new class of portable test devices for millions of allergists and endusers will be created