Dragon09/odtu_chatbot huggingface dataset:
making time organized labour and the politics of care leave

promoting worklife balance has been a focus of recent directives from the european commission and a source of policy innovation in several countries social policies that make time for family and selfcare are important tools for building sustainable work but countries vary considerably in the extent to which such tools are available trade union organizations may play an important role for developing statutory carerelated leave rights and protections particularly as women still provide a bulk of family caregiving and now constitute a majority or nearmajority of union members in many countriesthis project will use a novel mixedmethod design to investigate organized labours relationships to national leave policies that grant timeoff from work to address care needs including leave to care for a child aging parent or ill spouse or to address selfcare needs through sick leave or disability benefits quantitative analyses will examine unionpolicy relationships across rich democracies starting in 1965 and qualitative analyses will examine organized labours policy advocacy in ireland france and the netherlands analyses of predictors will distinguish between different types of social provisions consider differences in trade unions and the types of workers they represent investigate the mechanisms of potential union influence over policy and compare unionpolicy relationships across different institutional contextsa central ambition is to integrate the interdisciplinary fields of comparative policy analysis and social movement research to advance comparative labour studies and develop new theories of unionpolicy relationships the project will additionally develop data infrastructures offering muchneeded longitudinal comparative data on different types of care leave provisions overall the project will assess the extent to which organized labour can be a partner for developing social policies that promote sustainable work for the future
extracellular vesicles fiber optic surface plasmon resonance selection and analysis

the extracellular vesicles ev field is growing due to increased interest in their roles in diagnostics and therapeutics current methods to purify and quantify evs take a long time introduce a bias are costly and imprecise thereby hampering advancement in the ev rd field while the lack of methods to quantify evs directly in crude samples restricts applications in diagnostic and bioprocessing fox has established a breakthrough labelfree technology in a fiberoptic concept in an automated platform that allows biomolecular interaction research of biologicals the fox affinity isolation and simultaneous quantification with a sensor dip probe is a new selective no bias automated scalable 4x faster time24 and specific purity 95 method that allows accurately quantifying ev directly from crude samples moreover it allows for the first time to release the quantified and specifically selected evs for further quantitative content analysis
cerebellar ataxia spatiotemporal transcriptomics atlas

inherited cerebellar ataxia cas is a large and multifaceted group of rare genetic neurodegenerative diseases affecting mainly the cerebellum and its connection leading to the loss of coordination and ataxia phenotype purkinje neurons pn are crucial cells for cerebellar functionality but also very sensitive neurons indeed they were found as the most vulnerable cerebellar neurons in many cas both in mouse and human samples although cas show high genetic heterogeneity and have different diseasegenes they converge into similar phenotypic features and recent papers highlighted common deregulated key pathways the current research landscape indeed points out towards the identification of calcium glutamate and inositol phosphate signaling as frequently dysregulated however there is yet no comprehensive analysis of degenerative mechanisms in particular in pns that could prioritize molecular targets for therapeutic developmentour metanalysis readouts suggest converging pathophysiological points across different cas which so far remain poorly understood and need to be characterized to this aim in this application we propose to investigate in depth cerebellum ca signature taking advantage of cuttingedge singlecell profiling approaches in two flagship ca mouse models sca7 arca2 at two different disease stages the combination of transcriptomics singlenucleus rna sequencing probebased spatial transcriptomics and protein validation will help us to build a cerebellum atlas in the context of ca the goal will be reached through the effort and synergism of a multidisciplinary task force comprising biological omics approaches and computational expertisethe results will be presented and communicated during international conferences via social media and finally published in peerreviewed journals in order to reach a broad scientific community also the data will be used to inform lay audience through the collaboration with patient association
electrooptic frequency comb generation in the midinfrared

midinfrared midir spectroscopy is a nearly universal way to identify chemical and biological substances and to perform noninvasive diagnostics more specifically the 615 m wavelength range can be exploited to detect small traces of environmentally hazardous and toxic substances for a variety of applications including defense security and industrial monitoring while current optical systems in the midir range are based on bulky assemblies of discrete devices a challenging task is to make midir spectroscopy accessible in remote areas driving the development of compact and costeffective solutions to replace tabletop systemsin the project we aim at addressing new routes for high resolution spectroscopic systems based on dualcomb spectroscopy by developing innovative frequency comb sources the strategy developed in electrophot is based on the unique properties of graded index silicon germanium sige photonics circuits which are their transparency in a wide spectral range together with the ability to fine tune both the electronic bandgap and refractive index of sige alloys to make large progress in midir photonics based on these capabilities the original idea of the project is to exploit simultaneously optical nonlinear and electrooptic comb generation to generate compact frequency comb sources providing simultaneously wideband operation with fine and tunable resolution interestingly the photonics circuits will leverage from reliable and highvolume fabrication technologies already developed for microelectronic integrated circuits to provides a new playground in midir photonics
software defined vehicle support and coordination project

the automotive industry faces tremendous challenges in addressing decarbonization through electrification developing future solutions for inclusive safe and affordable mobility many of these changes require a radical rethinking of existing development processes with the share of software in modern mobility solutions continuously increasing the rising importance of the software layer results in the socalled softwaredefined vehicle sdv automotive software will be developed and adapted in continuous cycles therefore an abstraction from the underlying hardware needs to be implemented as a result the automotive industry is transitioning to an agile software development process the dramatic increase of software and complexity along with the advances of international competition in this domain calls for an approach in which nondifferentiating software is developed jointly as open source to address these challenges the eu together with industry governments and research institutions have launched the european sdv ecosystem to turn this into reality this proposal outlines the vision and activities for a coordination and support action federate softwaredefined vehicle support and coordination project aims to bring together all relevant stakeholders to accelerate the development of an sdv ecosystem to foster a vibrant european community and orchestrate the sdv rdi activities the consortium of federate is formed by major european oems automotive tiers semiconductor companies relevant industry associations and industrial sdv initiatives including the eclipse sdv wg and supported by a scientific board federate will work towards a common understanding on the vision of the sdv program and create an orchestrated advice for current and future projects in the sdv program in addition recommendations for future calls are prepared in alignment with a roadmap and joint vision document for accelerated sdv rdi created as part of the csa
mapping social value of participation in collaborative housing from a knowledgebased to evidencebased perspective

the rising housing cost overburden rate increasing house prices and rising rents in the eu and lack of access to affordable adequate quality housing has increasingly become a major concern for low and middleincome groups and vulnerable communities as a response to this ongoing crisis the last two decades have witnessed a shift and reemergence towards several forms of decentralisation cocreation and participative planning in housing in europe often referred together as forms of collaborative housing coh despite these prevalent forms that are typically driven with the need of affordability and social inclusion the challenges around housing continue to increase eg migration gentrification ageing population leading to greater sociodemographic issues social exclusion of vulnerable groups socioeconomic segregation displacement in rental housing markets etc and making it a chronic crisisbut lack of verifiable systematic and quantitative evidence is a major barrier and does little to support the potential of these coh forms in mitigating the issues the knowledge around participation in coh or its impact remains qualitative and fragmented compromising a comprehensive understanding of the actual social value brought by them in terms of how they are capable to address the changing dynamics of housing in europe with ongoing and emerging issuesthereby solveh proposes a clear structure to develop an evidencebased index enabling to map of social value of participation and capture the social impact of collaborative trends in housing the project addresses the social complexity project through mixedmethod approaches from interdisciplinary disciplines eg sociology citizen sciencethe main objectives are to understand the social value of participation in coh enable evidencebased quantification of social value of participation in coh localise the developed social value index and facilitate its application for coh in europe
fifth generation technology standard for european union governmental satellite communications

5g nonterrestrial networks 5gntn satellite networks will soon be able to handle all types of applications and provide service to a massive number of users in this complex and dynamic network ecosystem and endtoend adaptation of 5gntn towards the eugovsatcom services requirements and use cases is of capital importance to efficiently deploy european governmental satellite services to enable such a vision 5ggovsatcom targets the development and evaluation in a natural user environment of different key enabling technologies that aim to provide full integration of 5gntn in the eugovsatcom framework in the radio technologies domain 5ggovsatcom targets the development of necessary adaptions and enhancements of radio access procedures to attend to geostationary mobile terminals in the exclusive governmental xband furthermore the integration of 5gntn user equipment with an antenna operationally focused on onthemove and onthepause scenarios are planned in parallel in the internetworking segments 5ggovsatcom aims to provide a seamless handover between terrestrial networks and ntn via a smart gateway while enhancing corenetwork functionalities finally all project developments are planned to be first validated in a controlled lab with satellite connectivity and posteriorly experimentally tested in close collaboration with final users these latter tests will constitute the first 5gntn trials with final users devoted to i ubiquitous telemedicine in maritime areas and ii crisis management connectivity bubble
acceleration towards leo automatic space safety

the atlas project aims at developing the first service of space safety based on a network of 7 radars deployed around the world with a new design for scanning and tracking capable to detect debris down to centimetric size and through fusing data from its network and other sources look up space aims at extending the lifetime of satellites through collision avoidance and decreased number of collision avoidance manoeuvres of satellites this service will be applicable to small satellite fleets as well as to whole satellite constellations this will provide the eu with the first sovereign solution for space safety dedicated to coordinating all stakeholders and automatising processes
engineering high performance biocoatings from renewable reactive building blocks

uv curable polyurethane pu coatings play a major role in a wide range of industries due to their versatility excellent performance and energyefficient production and application the global pu coating market was valued at usd 174 billion in 2021 unfortunately pu coatings still largely depend on fossilbased raw materials biobased alternatives are restricted to a negligible market volume and to date there is no highperformance alternative with a biogenic content above 50 available bioring proposes a synthesis platform that combines biobased monomers and crosslinking agents to produce highperformance uvcurable pu coatings with 95 biogenic content to reach this ambitious goal we will develop the key pieces required to produce fully biogenic pu coatings from currently available biobased components our modular approach allows to finetune the characteristics of the coatings and adjust them to the requirements of highly demanding european industries furthermore the platform will be able to adapt to future developments of new biobased building blocksthe development process will be guided by process simulations and modelling of product properties we will demonstrate our approach for two use cases automotive and construction including not only functional validation but also an economic analysis for future scaleup where the components can be produced within a biorefinery we will assess biodegradability as well as different recycling scenarios for coated products according to the respective industry demands and standards bioring includes a thorough lca and lccthe bioring consortium is composed of 12 partners including rtos smes large enterprises and an industrial association from 5 european countries the participation of producers and end users will guarantee access to stakeholders and open the doors to future scaleup bioring will allow companies to comply with european legislation and make them more competitive globally
a novel nash model for target and drug candidate identification

nash is the progressive form of nafld that underlies the development of fibrosis cirrhosis and hepatocellular carcinoma the global prevalence of nash is estimated at 1 billion individuals nash is a major cause of death now the major reason for liver transplantations and the disease is an important cause of hepatocellular cancer hcc currently there are no fdaapproved drug therapies available within the erc project hepaspher a new liver model was developed in which human hepatocytes and nonparenchymal cells are grown in a 3d spheroid structure that phenotypically closely resembles human liver in vivo with respect to transcriptome proteome and metabolome for up to 35 days this model has proven to be of valuable use for the development and treatment of liver diseases such as steatosis cholestasis hepatitis insulin resistance and fibrosis in the spheronash project we focus on a more complex system whereby both inducers and mechanisms of nash formation druginduced inhibition of nash as well as studies of extracellular matrix ecm degradation including collagens and the role of ecm degradation control in the development and treatment of nash can be studied for this purpose hts based screening in the spheronash spheroid system will take place utilizing both sirna target libraries and chemical inhibition libraries at hepapredict ab with a proposed delivery of novel compoundstargets that can be further processed in drug developmental projects we propose to commercialize the spheronash model itself but also to commercialize targets and compounds found by sirna and compound screening that regulate nash formation and degradation we aim to assess and demonstrate the commercial value to the pharmaceutical industry by building a strong knowledge transfer strategy the spheronash model thus has great fundamental and commercial potential in nash drug discovery and development
fast gated superconducting nanowire camera for multifunctional optical tomograph

traditionally monitoring of organs and deep body functional imaging is done by ultrasound xrays incl ct pet or mri these techniques only allow for very limited measurements of functionality usually combined with exogenous and radioactive agents in this project we propose an innovative light sensing solution a fast gated ultrahigh quantum efficiency singlephoton sensor to enable multifunctional deep body imaging with diffuse optics the new type of sensor is based on superconducting nanowire singlephoton detectors that have shown to be ultrafast and highly efficient however until now the active area and number of pixels has been limited to micrometers diameter and tens of pixels we propose the combination of two new readout techniques optical gating and charge coupling to overcome this limit and scale to 10000 pixels and millimeter diameter in addition we will develop new strategies for performing tdnirs and tdscos to use this new light sensor optimally with montecarlo simulations we will implement the new light sensor in an optical tomograph and achieve a 100x improvement of snr compared to using existing light sensors with our proposed multifunctional optical tomograph we will be able to image deep organ and optical structures and monitor functions including oxygenation haemodynamics perfusion and metabolism
a combined photoelectrochemical and fluorescence imaging system for investigating nanoparticlecell interactions

nanoparticles nps have become increasingly attractive for biomedical applications such as targeted drug delivery cancer therapyand bioimaging due to their excellent properties the investigation of npcell interactions cellular uptake and cytotoxicity is crucialto the development of safe and effective use of np in living organisms however current methods for studying npcell interactionsrely on fluorescence microscopy and complementary methods need to be done separately therefore we propose to develop a novelimaging system that can conduct labelfree photoelectrochemical imaging and fluorescence imaging simultaneously so that electrical signals from the basal side of cells and fluorescence signals can be obtained in tandem a laser with a suitable wavelength will be used as the excitation source for both fluorescence and photocurrent this imaging system will be validated by monitoring cell viability withfluorescence assay and photocurrent imaging and by monitoring the cellular uptake of model nps to correlate the physicochemical properties of nps to their uptake efficiency and toxicity these validation experiments will be compared with established techniques this system will be used to study neuronnp interactions to reveal the mechanism of nps functional effects in neuronal activities the combined imaging system will help us gain a deeper understanding of npcell interactions and will offer a labelfree method for assessing the toxicity of nps in the biomedicine field therefore this project will facilitate the rapid development of safe and effective nanomedicines and nanodelivery systems that allow sitespecific targetoriented delivery of precise medicines to treat and prevent various diseases this will significantly increase the impact of nanomedicines in the clinic increase the quality of life for an ageing population and help us respond to public health emergencies effectively
highthroughput optimization for indoor organic photovoltaic energy systems

recently the growing popularity of internet of things iot applications has garnered substantial interest in autonomous offgrid energy harvesters such as organic photovoltaics opvs from indooravailable energy sources namely artificial lights the success of iot will rely on avoiding battery maintenance for the billions of sensors postulated to be deployed using available renewable energy at deployment for powering the sensors the discovery of novel organic materials and diverse device strategies led to a big leap in the power conversion efficiency pce of opvs up to 31 under indoor lights despite the augmented usefulness of indoor opvs with record performance several challenges thus far need to be attempted the highthroughput optimization for indoor organic photovoltaic energy systems hopes project introduces a novel concept of combining advanced highthroughput experimentation techniques with a standalone tunable light source hopes is interdisciplinary and multidisciplinary and includes the development of highly efficient indoor opvs along with the scaleup property that is integration of iot devices with the highperformance opv in hopes the researcher will implement a computercontrolled light emitting source to achieve a desirable light spectrum by exploring a large library of illumination spectra this will lead to achieving the highest possible pce 40 for a given opv system the traditional experimental techniques cannot meet the recent progress of indoor opvs owing to their limitations of time and workforce thus hopes will explore a variety of materials at an unbeaten pace by combinatorial screening to reach the highest pce in indoor opvs the researchers experience with the indoor opvs will be combined with the host supervisors expertise in highthroughput experimentation to successfully implement hopes the advanced training gained during hopes implementation will contribute to excelling the researchers professional career
role of mitochondriaassociated er membranes on microglia activation implications for alzheimers disease

alzheimers disease ad is an irreversible neurodegenerative condition affecting 50 million people worldwide despite intense research the pathological mechanisms of ad are still unclear many genetic loci robustly associated with ad code for proteins that are preferentially or exclusively expressed in microglia supporting a causal role of microglia as key players in disease initiation and progression microglia are brainresident immune cells that upon activation reorganize their cellular membranes by coordinating a network of lipid pathways at unique subcellular regions localized in the endoplasmic reticulum called mams mitochondriaassociated er membranes the membrane contact site between er and mitochondria hyperactivation of mam is shown to be associated with ad pathogenesis however the impact of mam alteration on microglia biology is unexplored the main objective of inflamam is to determine the mechanism by which mam regulates microglia activation and the impact of defects in mam and lipid homeostasis in the context of ad to that aim we propose to combine cuttingedge lipidomics and proteomics approaches with pharmacological and genetic mam intervention strategies to identify relevant molecular drivers that enable the crosstalk between lipid metabolism and immune signaling at mam in microglia by proving the role of mam as an immunometabolic hub for inflammation and a driver of ad pathogenesis we believe this innovative project has the potential to pinpoint relevant lipid pathways as new targets for pharmacological intervention to alleviate the symptomatology related to microglia in ad