Dragon09/odtu_chatbot huggingface dataset:
highresolution boron and beyond geologic reconstructions for carbon and climate processes

the link between climate and co2 is not always straightforward particularly during periods of multiple climatic and environmental changes but atmospheric carbon dioxide co2 plays an important part in determining climate on human and geological timescales for example state dependency of climate sensitivity the response of earths temperature to co2 is a critical unknown for future climate projections and policy strategies another unknown is the response of the antarctic ice sheet ais at different co2 thresholds for its melting and growth hysteresis despite the fact that this will ultimate determine the magnitude of future sea level rise existing records suggest that the ice sheet margin waxed and waned since the eocene 50 million years ago ma while co2 varied within the likely range projected for year 2100 and earths temperature progressively cooled highborg aims to resolve climateaisco2 unknowns on three periods of the geologic past 5246 ma hot earth high co2 likely ice free largely unexplored 3923 ma when ais was established and 1713 ma cold earth low co2 dynamic ais highborg focuses on reconstructing co2climate feedbacks at millennialorbital timescales a medium risk high gain opportunity necessary to resolve warming and cooling periods at different climate states to achieve this a new automated system for purificationanalysis will be developed accompanied by a laser ablation splitstream approach utilising new marine archives and cuttingedge methodologies seasonal reconstructions from contemporaneous tropical corals will provide a novel way to constrain seawater composition necessary to obtain accurate estimates of co2 earth system modelling incorporating reconstructions will provide a new understanding of the mechanisms driving state dependent interactions between earths orbit co2 temperature cryosphere and carbon cycling increasing our confidence to sea leveltemperature projections for the future
integration and digital demonstration of lowemission aircraft technologies and airport operations

achieving the goals of climate neutrality by reducing the impact of aviation is a task that requires a carefully drafted roadmap for the development of disruptive technologies and concepts of operations with particular attention to the emissions of pollutants and noise in airport local airport areas a synergetic approach is needed that combines together interventions on the aircraft side and on the airport side this calls for coordinated efforts in developing technologies that not only provide benefits during cruise conditions but also are capable of improving the local air quality and noise in airport areas where the impact of pollutants and annoyance to local communities has been demonstrated to be quite large in terms of morbidity and mortality indigo is a collaborative project between academia research centres and airports that aims at identifying the margins of improvement in airport local air quality and noise resulting from the introduction of a new nonconventional midrange aircraft featuring distributed propulsion based on hybrid electricsustainable and conventional fuel powertrain and large aspectratio wings capable to fly quietly and in zerotolowemission mode ie electric and saf at low altitudes near airports and resort to conventional aviation fuel only when required eg at higher altitudes or to recharge batteries during cruise indigo will explore a new paradigm for the nextgeneration of silent and clean midrange aircraft and for the way such a new aircraft will allow transforming the operations at and near airports it will introduce improved methods for the analysis of future aviation environmental impact that under the filter of uncertainty will be able to account for nonconventional aircraft performance and future airport scenarios
targeting peripheral nerves a method for therapeutic modulation of inflammatory disease with noninvasive temporal interference

excessive inflammation underlies the development of inflammatory diseases eg rheumatoid arthritis crohns disease inflammatory bowel disease and cardiovascular disease the most common cause of death in the world human physiology is controlled by defined molecular mechanisms commonly controlled by specific target nerves and their associated reflexes which optimize function for example molecular mechanisms regulating inflammation harnessing the power of the inherent nerve reflexes which are evolutionarily adapted to regulate specific molecular mechanisms holds promise to overcome many of the drawbacks intrinsic to current drug therapies this approach designated bioelectronic medicine presents a radically improved way to both treat and better understand disease with increased adaptability and precision the vagus nerve as shown by the team in this project and other groups plays a key role in regulating key proinflammatory cytokines proresolving mediators and controls inflammation however specific targeting of the vagus nerve has required neurosurgical implantation of a pacemakerlike stimulator device with a control unit a connecting cable and an electrode implanted at depth the requirement for highly specialized surgery significantly limits the usefulness and possibilities for implementation of nerve stimulation in treatment of inflammation surgery and device implantation also carries risks for permanent tissue damage local inflammation infection and other potentially serious complications treatment will generate a precise noninvasive nerve stimulator that uses temporal interference in an ultrathin form factor enabling patchbased applications that will i target one nerve of interest and avoid offtarget stimulation ii avoid surgery iii simplify effective use and iv enable bioelectronic medicine
strengthening european startups through interconnected and inclusive innovation ecosystems

the innovation ecosystem of the eu is suffering from a strong fragmentation with a big gap between innovation leader regions and emerging innovators this divide severely limits the potential for innovative startups from emerging and moderate innovator region to access capital and get adequate support for bringing their innovations to market to tackle these challenges innovateeu will strengthen and connect five local innovation ecosystems the innovation leader region badenwürttemberg bw in germany the moderate innovator regions of lithuania and aragon in spain and the emerging innovator regions of latvia and northeast romania its goal is to address the innovation gap between these regions connect them to an euwide network of innovation ecosystems and strengthen their deep tech startups and scaleups by building on three fundamental pillars i a detailed analysis of the target groups and needs of the local innovation ecosystems followed by knowledge exchange and a detailed action plan to address the disparities ii the formation of the interconnected and inclusive innovateeu innovation support community and its connection to european communities iii direct support and trainings for promising deep tech startups and scaleups providing them with the necessary knowledge tools and contacts for successfully upscaling their business models and bringing their products to market through this approach innovateeu will create an interconnected and inclusive innovation ecosystem with access to a wider european innovation support community and concrete pathways for existing and emerging deep tech entrepreneurs to access growth and investment opportunities this will result in the overcoming of the innovation gap between moderately and highly innovative regions in europe and the unveiling of disruptive and otherwise hidden startups and scaleups in deep tech
implantable sensors and ultrasonic data link with triggered bioresorption for nextgen wireless cardiac monitoring

cardiovascular diseases are the leading cause of death globally monitoring heart functions and ischemia is critical for survival after cardiac surgery standard monitoring methods such as echocardiogram and elisa blood test provide singletime measurements they are available only in hospitals and there is no continuous monitoring method after patients are discharged leading to a high rate of recurrent heart failures and rehospitalization implantable medical devices are used for treatment of various disorders however their nonresorbable nature necessitates an implant removal surgery that puts additional risk of infection and stress on patients and limits their use in postoperative monitoring bioresorbable implants may soon revolutionize postoperative monitoring methods the surgeon will implant a small patch onto the heart during surgery enabling continuous cardiac monitoring and early alerts for heart failure this will reduce sudden attacks rehospitalizations and financial burden of health care then once the monitoring period ends triggering with a light source will dissolve the implant thus providing a significant second chance for the survivors of cardiac failure without the burden of secondary surgery the technological advancements to bring this vision to the clinic are not available yet 2ndchance will facilitate this vision by building components of nextgeneration wireless implants with triggered bioresorption for cardiac surgery through groundbreaking approaches this interdisciplinary project aims to develop 1 bioresorbable sensors compatible with the inbody environment 2 batteryfree ultrasonic communication and 3 encapsulation layer with triggered bioresorption followed by 4 integration and animal tests the versatility of the 2ndchance will also yield potential breakthroughs in fields where monitoring of tissues and biomarkers is crucial such as neurology and ophthalmology and open new research perspectives
multicriteria analysis of the technical environmental and social factors triggering the pimby principle for wind technologies

wendy aims at unravelling the factors triggering social acceptance of wind farms through an indepth analysis at three dimensions social sciences and humanities environmental sciences and technological engineeringfor that the project will implement a series of local actions promoting the wider adoption of the project solutions including guidelines reports and handbooks which will be created to boost the understanding of wind farms decision making processes and enhance energy citizenship this will be supported by the spatial multicriteria wendy toolbox a tool able to identify the optimal turbines siting with the minimum environmental impact and highest social acceptance likelihood all developed models methods guidelines and tools will be implemented within 10 wind projects spread across 4 countries these have been selected considering geography north vs south europe maturity stage viability phase planning phase shortterm operation phase longterm operation phase type of wind energy onshore offshore floating fixed and coexistence with other activities agriculture fisheries energy communitiesin these locations outreach activities tailored to their specificities will be performed creating the wendy knowledge hubs which will incorporate citizens local authorities business owners and value chain actors of wind energy wendy hubs will serve as a baseline for the wendy knowledge exchange platform a forum that will be developed to facilitate the exchange of knowledge between decision makers and key stakeholders within wind farms planning processesfor a successful implementation of the project activities all the value chain and the bestinclass expertise is involved in the project consortium including 9 partners from 6 european countries 1 large company egp 2 smes wr qplan 1 university cbs 2 rto circe nina 1 energy community mec 2 nonprofit organisations and associations nowc appa
sweet origins of life peering into the past with todays biochemistry

approximately four billion years ago chemical and geological processes on the ancient earth caused a continuous increase in the complexity of organic molecules ultimately leading to rna dna proteins polysaccharides membraneforming amphipaths to metabolism and the roots of biology but how did it all begin how did chemistry become biology there are many indications to the starting point ie the huge set of small molecules that existed on early earth as well as the end point of chemical evolution which is the beginning of biology and the first living organisms in order to unravel the gap of what happened in between it is crucial to analyze plausible routes to the origin of life while much effort to date in the context of formation of primordial polymers has focused on the generation of nucleic acids and to a lesser extent the formation of peptides the role of sugars in the chemical origins of life has never been investigated outside the roles of sugars as structural elements of nucleic acids and in metabolismsugars are ubiquitous biomolecules providing an energy source taking part in biosynthesis providing structural support and even acting as catalysts sugars are often found in conjugation with other biomolecules eg glycolipids i hypothesize that the tightly intertwined biological dependencies of sugars and other biopolymers and their mutualistic relationships reflect a long coevolutionary process the main goal of this proposal is to bridge the gap from early prebiotic chemistry to todays complex biochemistry by studying mutually catalytic networks involving sugars following our preliminary findings which successfully demonstrated the formation of oligomers composed of sugars and amino acids my team will generate and characterize a multitude of heterogenous glycancontaining conjugates and study their emergent assembly and function this study will furnish a deep understanding of how and why lifes biochemistry emerged
a heterogeneous distributed prediction model for windsolar energy production

to achieve the european unions green transition goal solar photovoltaic pv and wind energy are widely adopted which pose great challenges to the reliability and safety of existing energy systems the stateoftheart methods mainly concentrate on the prediction of a single energy form either wind or solar there is limited research on joint forecasting for windsolar energy due to the challenges of data heterogeneity and data silos for different wind farms and solar pv plants this project develops a heterogeneous distributed prediction model for joint windsolar energy production answer based on heterogeneous data sources at different wind farms and solar pv plants a global model will be generated by the fusion of heterogeneous models from all wind farms and solar pv plants coordinated by a central server to achieve the research goal this project proposes four work packages including 1 development of model specifications which use a twolevel structureclientlevel and serverlevel 2 development of a generic seamless forecasting client model that supports multiple timescale and horizon prediction 3 model aggregatioin for heterogeneous client models and 4 model deployment and evaluation in a living lab for the robustness of the proposed answer model this proposal answer specifies the resources needed for this project including the quality and capacity of the host university mentors data and experimental facilities this project will enhance the scientific skills and innovation capability expand research horizons and establish research collaborations of the applicant a twoway knowledge transfer approach in energy big data distributed modeling and energy system analysis is proposed to ensure benefits between the applicant and the host university the proposed model will make a significant contribution to the state of the art in renewable energy wind and solar production forecasting and the eu climate goals
beyond the big tech contentious speech on small platforms

in 2022 following elon musks takeover of twitter users of the microblogging platform who feared a rise in farright discourses with the new owners idiosyncratic free speech policies announced their migration to mastodona free federated social networking service in 2021 in india following twitters actions against hateful speech religious majoritarian actors rushed to secure their spot on koo a new homegrown platform in the uk britain first a farright movement known for its antiimmigration rhetoric migrated to gab microblogging and telegram messaging after facing bans on twitter and facebook such emerging trends signal the growing importance of smaller social media platforms drawing the focus on such platforms this project sets up small platform discourse as an object of anthropological inquiry grounded in anthropology and backed with policy analysis algorithm auditing and computational natural language processing nlp and social network analysis sna smallplatforms will be the first study to explore small platforms in a crosscultural framework spanning onground and online inquiries and the global north germany uk and the south kenya india using a unique conceptual model that considers the restrictive and generative sides of small platform discourse as a dialectical relation and explicating three structural tensions among global capital technopolitics and speech regulation that underlie this relation the project asks whether and in what ways forms of contentious speech are bound up with practices surrounding small platforms through this empirical excavation with policy implications the project will theorize digital discourse beyond the conceptual language of the centralizing big tech with extensive theoretical and comparative work on online speech the pi will drive this research using networks and knowledge about the selected sites and the profound global dimensions of digital media
biomaterials design through machine learning for sex and diseasespecific bone regeneration

osteoporosis a widespread disease that causes bone fragility currently afflicts over 32 million europeans with rapidly increasingprevalence expected due to population aging the costs of therapies for osteoporotic fragility fractures total more than 50 billion peryear in the eu postmenopausal females are at especially increased risk for osteoporosis and the regenerative capacity of healthybone also differs between the biological sexesalthough biomaterials have been developed to aid bone regeneration after injury the influence of biological sex and osteoporoticdisease have not been taken into account for such biomaterials design excitingly the advent of machine learning ml offers thepotential to unravel the effects of sex and osteoporotic disease on biomaterials bone regenerative capacity and to apply theseinsights to design biomaterials optimized to these characteristicstherefore the sedibone project will for the first time exploit ml to elucidate the influence of sex and osteoporotic disease onbone regeneration and to translate these insights towards design of an entirely new class of biomaterials with sex and osteoporoticspecificity by enabling automated localization of tissue defect sites and detailed tissue cell and interface identification sedibone will deliver an analysis tool that efficiently and reproducibly quantifies bone regeneration outcomes in male or female and healthy or osteoporotic preclinical animal models aim 1 these indepth insights will then serve as inputs for a design tool to determine the biomaterials designs correlating to optimal regenerative success based on sex and osteoporosis with validation through ex vivo demonstration aim 2 sedibone will thus crucially synergize and advance efforts to design a new generation of patientspecific biomaterials and accordingly inform therapeutic solutions for regeneration of bone tissue in the unexplored areas of sex and diseasebased specificity
groundwater sustainability and crop production

groundwater is the largest freshwater resource on earth and is crucial for people and the environment in many regions around the world groundwater is used unsustainably consequently groundwater levels drop leading to drying rivers and wells salt intrusion land subsidence and groundwater depletion irrigated agriculture is the largest user of groundwater worldwide and is responsible for current hotspots of negative impacts especially for intensively irrigated regions of the world already many rivers in these regions have reached their environmentally critical streamflow which is necessary to maintain healthy ecosystems with expected increasing water demands and climate change the pressure on our groundwater resources will increase further and new regions experiencing negative impacts will develop to reduce and prevent these impacts groundwater uses should be reduced at the same time crop productivity should be maintained to protect global food security this poses for me the urgent question what is the current and future environmentally safe operation space for global groundwater use and what is and will be the impact of sustainable groundwater use on crop production worldwide in this project i will provide a better understanding of groundwater availability worldwide my project will define the environmentally safe operating space for current and future groundwater use and will define and quantify the key tradeoffs between sustainable groundwater use and crop production i will develop a novel and innovative modelling framework that connects groundwater surface water and crop growth the model will be linked novel future water demand scenarios including adaptation strategies towards sustainable groundwater use worldwide the results will show globally where and when competition for groundwater between the environment and crop production is largest and whether sustainable groundwater use can support current and future crop production
the role of integrated fire management on climate change adaptation for ecosystem services in tropical and subtropical regions

in the last few years extreme wildfires have risen to international prominence with widespread media coverage and political attention triggered by devastating fires in many places of the world eg france greece italy brazil the amazon and california such fires get out of control and devastate large areas causing unprecedented losses on biodiversity emitting huge quantities of greenhouse gases into the atmosphere causing human losses and smokerelated diseases and ravaging entire neighbourhoods villages or even towns climate change is among the key drivers of such wildfires at the same time wildfire regimes have been profoundly modified by direct eg landuse change fire suppression policies and indirect eg climate change anthropogenic actions integrated fire management ifm or sustainable fire management has been identified by the international fire community as one of the key solutions to address the problem requiring an interdisciplinary approach ifm includes sets of actions aimed at reducing the extent and severity of undesired wildfires while maintaining or improving biodiversity ecosystem services and human wellbeingfireadapt aims at addressing the full diversity of fire types and their different contexts by bringing together expertise from across regions from the mediterranean basin and latin america for the purpose of improving our understanding of the role of ifm for wildfire prevention and for enhancing natural and cultural ecosystem services the consortium has set up six study hubs in mediterranean countries spain france italy and latin america brazil mexico argentina to facilitate sciencepractitioner exchanges and to enhance collaborations and networking the ultimate intention of fireadapt is to contribute to improving knowledge on what practices of ifm can enhance carbon abatement and naturebased solution potential as well as wildfire risk mitigation in culturally just and meaningful ways