Dragon09/odtu_chatbot huggingface dataset:
probabilistic nonrigid registration for safe brain tumor resection

brain tumors strike people in the prime of life surgical resection is the initial treatment for nearly all brain tumors and aims at maximizing the extent of tumor resection while preserving the patients cognitive function to optimize this tradeoff neuronavigation systems have been developed to provide intraoperative guidance to surgeons these systems allow for the visualization of the position of surgeons surgical tools relative to the tumor and critical brain areas visible in preoperative magnetic resonance imaging however these systems become inaccurate as the surgery progresses since they do not account for brain deformation and tissue resection occurring during surgeryin an interdisciplinary effort project safereg combines the researchers background to the expertise of computational scientists from inria and clinicians from parisian hospitals its objective is to invent a novel image registration methodology with intraoperative ultrasound that is rich enough to capture complex deformations occurring at the tumor and resection cavity boundaries fast enough to be employable clinically and interpretable enough for informed decisionmaking by neurosurgeons this will be accomplished by pushing the envelope of scientific knowledge in 1 crossmodality domain adaptation for weakly and unsupervised image segmentation 2 modalityinvariance representation learning using contrastive learning 3 nonrigid registration with discrete probabilistic methods 4 simulatedbased variational inference for registration uncertainty quantification that leverages biomechanical knowledge this research has the potential to deliver accurate and informed imageguided surgery conferring a lower risk of new neurologic deficits and improved patient prognosis beyond neurosurgery it has broad applications to additional areas of imageguided therapy including spine liver and prostate surgery
underground large scale seasonal energy storage for decarbonized and reliable heat

today the heating sector is not on track toward achieving the iea netzero targets it represents more than a third of the energy demand and it mainly relies on fossil fuels district heating is recognized as a major solution allowing decarbonization of the heating sector the integration of largescale seasonal energy storage compensating for the mismatch between supply and demand whilst ensuring the service is key for a wide spread of district heating uses4heat aims to demonstrate innovative largescale seasonal thermal energy storage solutions enabling a future decarbonized and reliable heating supply uses4heat demonstrates at trl8 and for a oneyear test campaign two innovative costeffective largescale seasonal underground tes units to maximize the availability and resilience of heating supply while reducing energy losses and environmental impact uses4heat seeks to demonstrate the storages as fully integrated units in commercial largescale district heating networks and industrial waste heat recovery and fulfilling industrial thermal demand in doing so uses4heat also demonstrates six innovative key enabling componentstechnologies and their integration with seasonal storages advanced drilling equipment and remotely controlled machines halving drilling times innovative layered hightemperature borehole pipes efficient groundwater heat pumps integrated with aquifer storages hybrid solar panels and thermal solar collector and accurate aibased energy management tools uses4heat will systematically demonstrate the effectiveness and technoeconomicsocial viability of innovative largescale seasonal energy storages ensuring limited capex reduced environmental impact and energy losses efficient integration in district heating and accumulation of various sources of heat and granting reliable and decarbonized heating supply
inequality and integration

socioeconomic inequality has become increasingly intertwined with immigrant status in many western european societies one important question is whether and how socioeconomic disadvantages among immigrant parents hamper the integration of their children this project focuses on inequality and spatial segregation and how they affect the children of immigrants in terms of their wellbeing and structural social and cultural integration we ask how integration in different dimensions comes to be analyzing the internal workings of schools including grading ability grouping and social relations among classmates the complex nature of the questions we address requires outstanding and uptodate data one of the major contributions of this project is to collect such data this will be achieved via a longitudinal survey conducted among 5000 pupils in 100 representative swedish comprehensive schools coupled with parent register and digital data the project also offers excellent opportunities to assess changes in inequality and integration over the last 15 years through comparisons with preexisting data sweden provides a particularly interesting case due to its high immigration particularly from the middle east and africas horn increasing income inequality growing ethnic and socioeconomic school segregation and rapidly decreasing support for immigration the data will make it possible to study changes in interethnic social relations attitudes values religiosity and subjective wellbeing over time all within the context of the structural opportunities set by inequality and segregation the study also obtains information from teachers headmasters and registers on school organization resources and climate producing a comprehensive picture of the school setting in this sense it is more than a survey conducted in schools it is a survey of schools the pupils that populate them and the resources and milieu they are embedded in
photosynthesis in farred from cyanobacteria to plants

photosynthesis the process that sustains life on our planet by generating food and supplying oxygen is astonishingly inefficient less than 1 of accessible solar energy is converted into biomass by a crop improving photosynthesis is thus a promising approach to meet the increasing demand for food production the capacity to optimally harness light is a crucial factor in the photosynthetic process especially in lightlimited environments however plants only utilize the visible part of the solar spectrum 400700 nm which results in more than 50 of the photons reaching the earths surface being discarded this represents an important limitation especially for crops as plants in the field are close together and the light reaching the lower leaves is almost exclusively farred 700 nm until recently it was believed that 700 nm was the thermodynamic limit of oxygenic photosynthesis however the discovery of several species of cyanobacteria the prokaryotic ancestors of plant chloroplasts that can grow in farred light has shown that this is not the case how can cyanobacteria use farred light would it be possible to introduce the same mechanisms into plants to expand their spectral coverage and increase lightuse efficiency this project aims to address these questions by elucidating the mechanisms underlying farred light acclimation in cyanobacteria and redesigning them to be compatible with the photosynthetic system of plants this requires to address knowledge gaps related to the synthesis of novel pigments their integration into photosynthetic proteins and their impact on photochemical efficiency and photosynthesis regulation for this i will combine in vivo in vitro and in silico approaches ranging from molecular biology to ultrafast spectroscopy and modeling which is the trademark of my group this project will determine if implementing a farred response in plants is viable beneficial and a potential strategy for crop enhancement
minimize costs and maximize benefits in the transitionary european regional labour markets

it is evident that the process of green transition reshapes national regional and local economic landscapes and triggers change in ecosystems of various industries thereby highlighting the urgent need to plan efficient and fair strategies to minimise the costs of job destruction and maximise the benefits of job creation in a socially fair way and a geographically equal way in the wider patterns of reskilling isabels main objective is to provide a threefold solution to the aforementioned problem related to jcd with the use of new technologies such as ai and large language models llm that will 1 enrich our understanding of the socially and geographically uneven implications of this process across europe 2 broaden our knowledge on the factors underlying this process and 3 highlight pathways of minimising the effects of job destruction and maximising the benefits of job creation in a socially and spatially fair way the latter include upskilling and reskilling of workers and the reallocation of labour based on existing and forecasted skills shortages using ai technologies to support these tasks to achieve its main goal isabel will examine the above elements at 3 different levels i the aggregate european level among the eu uk and serbian nomenclature of territorial units for statistics 2 regions nuts2 using secondary data ii at 6 countries of focus denmark greece poland uk serbia spain collecting and analysing primary data and iii living labs focusing on 6 regions with diverse socioeconomic features
prefabricated mature blood vessels and tools for vascularized 3d cell culture

in 2020 the cell culture market was valued at 19 billion usd with consumables comprising more than 60 of the market the emerging 3d cell culture provides lucrative business opportunities for consumables and tissue test models but current technology and market supply lack an easy and reliable tool for the uncomplicated creation and cultivation of vascularized and perfusable artificial 3d tissue the current 3d cell culture consumable market offers only well plate inserts and organonachip systems for generating 3d tissues which are limited regarding tissue mimicry and complexity bioprinting while promising is still unreliable for reproducible vascularized tissue engineeringthe eic transition proposal vascondemand aims to fill this gap by providing three easytouse laboratory products for the generation and cultivation of perfusable vascularized 3d tissue 1 basicvasc an allinone bioreactor consumable for generation and cultivation of perfusable tissue culture 2 easyvasc prefabricated readytouse vessel channel networks without cells3 completevasc prefabricated matured cellcontaining vascularizationeasyvasc and completevasc both build on the basicvasc technology therefore basicvasc will be advanced for highthroughput production of precisely manufactured structures to be ready for the market the other products will be fully developed and characterized to allow improved vascularized tissue production with even more advanced and simpler readytouse systems this grant will be carried out by a highly motivated team with synergistic expertise in technology product engineering and business development working towards the foundation of a startup for the commercialization of the technology the proposed vascondemand has the potential to simplify the development of sophisticated test models for research and pharmaceutical approaches like drug testing leading to reduced animal trials and development costs
highperformance syngas upgrading into mediumchain carboxylates in high mass transfer gasphase bioreactors with in situ product extraction syn2value

there is an urgent need to foster the transition to renewable energies decarbonize the eu economy and consolidate a circular economy this requires the development of alternative and sustainable routes for producing fuels chemicals and intermediates biorefineries are a promising solution for producing a wide range of energy and marketable products while addressing another global environmental problem organic waste management globally 9400 mt of agricultural lignocellulosic waste could be used for biorefinery purposes syn2value will engineer and validate a novel integrative biorefinery platform capable of converting lignocellulosic wastederived syngas h2coco2 into valueadded liquid fuels and mediumchain carboxylates mcc syn2value will address two critical scientific challenges of syngas fermentation and chain elongation namely the poor mass transport of gas substrates and the low metabolic selectivity which limit its fullscale implementation syn2value approach is based first on the bioprospection and assessment of thermophilic 4555 c and acidophilic ph 4555 microbes capable of a highperformance conversion of syngas into mcc second the development of a groundbreaking singlestage syngastomcc platform based on an innovative high mass transfer gaslift bioreactor with insitu product extraction third adhoc mathematical models technoeconomic analysis and business planning will set the ground for a midterm full deployment of a new generation of costeffective and sustainable biotechnologies that will contribute to comply the green deal objective of making europe the first climateneutral region by 2050 while keeping the economic competitiveness of its worldleading chemical industry the fellow dr rodolfo palomo will conduct this action at the institute of sustainable processes of the university of valladolid under the supervision of dr ral muoz with secondments at wageningen university research and the sme greene
comics culture in the peoples republic of china

comics culture in the peoples republic of china chinacomx sets out to investigate the intellectual political social historical and transcultural dimensions of a medium still heavily understudied lianhuanhua literally linked images it studies them as a medium from the peoples republic of china and its place within the larger chinese and global comics culture studying the conditions of comic arts production distribution and consumption the project sheds light on how comics contribute to the project of nation building to the creation of a new socialist man and to the continued legitimacy of the chinese communist party ccp in addition it investigates how these at times highly propagandistic texts were read by ordinary citizens in clearly circumscribed case studies the project analyzes large amounts of literary and filmic adaptations the conventions of textimage relations and the breaking of these conventions narrative qualities as well as the visual language which is very much indebted to other visual forms of art including traditional chinese visual art cartoons propaganda posters photography and movies with its focus on practices and meaning making chinacomx moreover delves into the changing global cultural political and economic connections within the socialist cultural sphere within the greater china region east asia and beyond tracing distinct and changing relationships of domestic and foreign elements the case studies cover developments since the late 1940s to the present and situate concrete phenomena within larger developments and traditions in providing more knowledge about comic culture from china and in contributing to theoretical debates chinacomx aims to delineate the term lianhuanhua as a distinct genre and area of academic research that bears specific characteristics being embedded in a particular context of origin yet changing across time and space as japanese manga or francobelgian bandes desinnes
harmony within society

our living together is confronted with new challenges as our modern world widens our public sphere and smushes together groups with different value systems in turn agents take refuge in safe spaces where their behavior and speech are protected from bad inferences this ambitious project aims at proposing a unified framework building on the role of the dissemination of personal information to study social interactions and at fostering the academic communitys engagement on the study of these new challenges the first part will build a framework for divisive behaviors for which agents do not agree on whats right and wrong it will endogenize safe spaces and investigate their dark side externalities tribal behaviors outings as well as their inability to foster the learning of social norms it will also study theoretically and empirically how society and organizations create a common identity by defining legitimate conversation and designing common narratives the second part will challenge the received wisdom that transparency is beneficial for consensual behaviors and will bring evidence in this regard the argument will be based on the first modelling of moral licensing then applied to the coexistence of public and private spheres and on the formalization of when the right to oblivion is desirable finally and in line with the commonality argument the project will investigate coopetition with implications for international cooperation in innovation and competition policy
affordable and digital solutions to build the next generation of smart eu buildings

the 2021 epbd recast highlights buildings central role in the energy transition towards an integrated and renewable energybased eu energy system smarter buildings will support the digitalisation and decarbonisation transition to the benefit of building occupants owners and the energy system improving energy performance and reducing energy demands are even more relevant in the context of the repowereu plan to rapidly reduce dependence on russian fossil fuels and accelerate the green transition buildon seeks to develop a highly replicable generic solution to deliver intelligent building services facilitate the integration of heterogeneous systems and technologies and help build the next generation of smart buildings the main objective of buildon is to develop and demonstrate a smart transformer toolbox at trl8 to plan and achieve improved energy performance applicable to the broadest range of building typologies and smart readiness levels via a comprehensive demonstration campaign involving five representative reallife use cases this toolbox will offer affordable adaptative closetomarket and easytoinstall srialigned services to continuously monitor assess predict and optimise mapo services a buildings performance a unified representation of the building exposed through a universal building api will abstract all fieldlevel communication complexity allowing the energy devices homogeneous realtime monitoring and control moreover the generation of maturity level 3 and 4 digital twins will allow simulation and control of a building and its systems userfriendly decision support and user empowerment tools for facility managers and occupants will be part of the toolbox to explore understand and expand their buildings smart capabilitiesby providing a unified approach to interacting with buildings the floor is offered to develop a building app store that significantly accelerates the smart transformation of existing and new buildings
rewiring gene regulatory circuits to enhance central nervous system repair

the mammalian central nervous system cns is the epitome of complex cellular architecture still it has a limited capacity to selfrepair after an injury which contrasts with the regenerative potential of the cns in lower vertebrates regeneration unfolds by the orchestrated triggering of developmental gene expression programs after injury these programs are under the control of dedicated regeneration enhancer elements which grant adult cells transcriptional access to developmental genes neural stem cells in the mammalian cns lack the gene regulatory circuits that dictate when and where to activate the expression of developmental genes for regeneration consequently most of the cells lost to injury are never replacedthis proposal aims to rewire mammalian gene expression circuits to endow neural stem cells with the capacity to activate regenerative responses after injury first building on innovative technologies some of which that i developed we will identify injuryresponsive enhancer elements in the mouse spinal cord with single cell and spatiotemporal resolution then using machine learning we will decode the rules of injurysensing dna elements to design synthetic injuryresponsive enhancers for precise gene expression control in neural stem cells finally we will use synthetic enhancers in therapeutically relevant gene delivery systems to rewire gene circuits in order to promote the recruitment resident stem cells for cell replacement through the reactivation of developmental genes that would otherwise remain silentthe proposed research will uncover basic principles of gene regulation after cns injury and open new avenues for the design of smart gene therapies for regenerative medicine using synthetic regeneration enhancers
next generation of improved high temperature membrane electrode assembly for aviation

h2based fuel cell systems fcs are a promising solution to power aircrafts without emitting co2 or nox and thus have the potential to strongly reduce aviation emissions and pave the way to climate neutrality embedded in aircrafts fcs can supply nonpropulsive and propulsive energy without pollutant emission reduced noise emission and attractive energy efficiency the low temperature proton exchange membrane ltpem technology incl membrane electrode assembly mea emerging from the automotive industry is of great interest for aviation but thermal management issues are still be solved operated below 100c they exhibit attractive power density but are incompatible with aircraft environment due to poor heat rejection also current high temperature fcs operated around 160c are not at the expected level of performance for aviation despite interesting heat rejection performances the development of a newgeneration mea working at temperature above 120c and with performances equivalent to current ltpem mea is the key to unlock fc applications for aviationnimphea aims at developing based on the development andor optimisation of its components catalyst layer membrane and gas diffusion layer a newgeneration ht mea compatible with aircraft environment and requirements considering a system size of 15 mw and contributing to higher level fc targets a power density of 125 wcm at nominal operating temperature comprised between 160c200c mea components upscale synthesis and assembly process will be assessed by identifying process parameters and improved through an iterative process with labscale mea tests this disruptive mea technology will be finally validated in a representative scale prototype 165180 cm embodied in a singlecell simultaneously lca lcc ecoefficiency assessment and intrinsic hazard analysis will be performed to validate the mea development finally a trl evaluation will be conducted to validate trl4