Dragon09/odtu_chatbot huggingface dataset:
human communication as joint epistemic engineering

imagine ordering a drink at a diner pointing at an empty glass as an attentive waiter passes by how did you select that particular gesture and how could the waiter possibly interpret it as you intended as any other signal we use to communicate daily that gesture is highly ambiguous outside its context of use how can human communication work by using referentially flexible and contextually dependent signals mindsharing argues that interlocutors are communicatively effective because they jointly control their interactionspecific shared contextmindsharing integrates computational developmental and cognitive neuroscience to understand how that control is algorithmically defined culturally acquired and neurally implementedfirst using contextsensitive neural networks mindsharing identifies communicative control parameters during interactive multiturn linguistic and nonverbal referential games then assesses the value of those parameters as potential communicative universals across worldwide cultures second using prospective longitudinal studies mindsharing identifies the sociocultural experiences that influence the acquisition of communicative abilities during ontogenetic development third using concurrent brain stimulation and imaging in communicating dyads mindsharing tracks and perturbs the neural dynamics of communicative control parameters as dyads continuously adjust their shared context to novel communicative challengesmindsharing provides a novel causal account of a foundational element of human society the ability to communicate with referentially flexible signals mindsharing brings computational cultural and neurocognitive explanations into the interpersonal space where communication is used and where it is learned mindsharing will deliver what existing accounts have not delivered yet multilevel causal explanations of the multilevel human ability to communicate with referentially flexible and contextually dependent signals
communication in ancient anatolia

the project addresses the question of messages modes and participants in the communication of three anatolian cultures lydians luwians and phrygians ca 1200546 bce living in adjacent territories they were verifiably in contact with one another they are normally studied in isolation by different academic subjects leading to missed intercultural references and interconnections and preventing the reconstruction of a comprehensive picture the three cultures their interesting and diverse text sources their relationships with one another and their disunity as cultural entities are currently underresearched and only parts of their text corpora are available in modern editions the project will be the first to study both internal and external sources from other ancient near eastern and classical texts together using a combined semiotic and narratological approach examining text structure processes of meaningmaking communication and transmission texts and their material supports not only generate and exchange meaning they also preserve information on communication processes in the context of specific realms reading these texts with a focus on narrative and discourse will allow a new insight into formative parameters of ancient societies especially values cognitive patterns and the needs and motifs of the participants this marks a huge shift from traditional eventbased readings towards an analysis of belief and behaviour the project will be groundbreaking in its application and adaption of concepts from semiotics and narratology which were developed for the study of the modern world and have never before been applied to the study of these ancient texts the project will draw a new picture of cultural clusters and their parameters and provide new data for understanding ancient and modern identities and the potential of cultural differences its novel insight into communication can be extended to other ancient world studies
plasma membrane probes for photocontrolled release of signaling molecules

the cell plasma membrane pm of eukaryotic cells is a highly dynamic structure which plays important role in diverse biological processes such as cellular uptake neural communication muscle contraction and cell trafficking and signaling the pms are also responsible for communication between cells especially between neurons in particular the exocytosis process leads to liberation of neurotransmitters and neuromodulators on the other hand it is a platform for receptors that convert the recognition of neuroactive molecules into ion flux andor action potential therefore to modulate and monitor the activity of neurons an attractive approach is to design molecular tools that target cell pms in this project we will combine pmtargeting anchors with photoactive fluorescent cages capable to photorelease signaling molecules the obtained chemical tools memcages will be applied for 1 imaging the neuronal organization and 2 photocontrolled activation of neurons and brain of mice by photouncaging of signaling molecules close to pm the work is composed of 3 steps first is synthesis of memcages for dopamine and glutamate and their validation in solvents and model lipid membranes second is application of memcages in cellular systems which includes imaging and photostimulation of model cancer cell lines and neurons the first step will be in vivo validation of memcages which will be done during the secondment the applicant and the host laboratory plan extensive twoway knowledge transfer the applicant will gain knowledge and expertise in membrane probe design bioimaging in model membranes cells and animals whereas he will provide his expertise on design and characterization of molecular photocages for signaling molecules the successful utility of the developed chemical tools could open new avenues for the biologists and neuroscientists working in the field of cell signaling neuroscience and diagnosis and prevention of neurological disorders
holography and topological semimetals

weyl semimetals wsms are a recently discovered class of materials featuring an exotic array of properties with potential applications including the building of novel electronic devices the electrons in some wsms interact strongly with one another making their theoretical study challenging one tool for modelling strongly interacting systems is holography also known as the antide sitterconformal field theory correspondence holography has been used to model wsms before but there are open problems to do with holographically describing important features of real wsms in this project i will develop a new generation of holographic models and techniques capable of addressing several of these problems1 the effects of imperfections in a wsms crystal structure on its electronic properties particularly when the imperfections cause the electrons experiencing an effective curved spacetime2 certain nontrivial physics that occurs at the boundaries of wsms partly arising due to their topological properties3 holographically modelling a wsm with equations that are invariant under time reversal as is the case for the equations describing many real wsmsthe project will be carried out at nordita a joint department of stockholm university su and kth royal institute of technology the supervisor alexander krikun is an expert in holographic approaches to condensed matter physics through the research and training in the project i will obtain new skills such as numerical techniques for solving boundary value problems in partial differential equations su and kth both have condensed matter theory groups researching wsms from which i will gain expertise in nonholographic methods the project includes a secondment at instituto de fsica tericacsicuam in madrid with a group with expertise in anomalous transport an important aspect of wsm physics this secondment will support the research and training and foster new international collaborations
sustainable federation of research infrastructures for scalingup experimentation in 6g

6g is expected to emerge as key enabler for the intelligent digital society of 2030 and beyond providing superior performance via groundbreaking access technologies such as joint communication and sensing cellfree radio intelligent surfaces and ubiquitous wireless intelligence most importantly 6g is expected to trigger a total rethink of network architecture design which builds on the key idea of new stakeholders entering into the value chain of future networks the sunrise6g approach is inspired by the network of networks concept of 6g networks aiming to integrate all private and public infrastructures under a massively scalable internetlike architecture sunrise6g similarly aspires to create a federation of 6g test infrastructures in a paneuropean facility that will support converged testing as a service taas workflows and tools a unified catalogue of 6g enablers publicly accessible by experimenters and crossdomain vertical application onboarding experimentation and vertical application onboarding are offered via a tenant web portal that acts as a singleentry point to the facility serving end users eg experimenters and tenants eg vertical developers infrastructure owners 6g component manufactures the project execution is based on 4 pillars delivering a the implementation of new 6g enablers complementary to existing ones being developed in sns phase 1 projects b a truly scalable and 3gpp compliant federation solution that provides access to heterogeneous resources and devices from all europe c a federated ai plane aligned with aiaas and mlops paradigms which promotes a collaborative approach to ai research which benefits immensely from scalingup datasets and models and d a commonly adopted experimentation plane which offers common workflows to experimenters
study of molecular events triggering the cytosolic enrichment of sumo activating enzyme and its implications in seed quality

posttranslational modifications by sumo small ubiquitinlike modifier modulate protein activity through regulation of subcellular localization protein activity and stability and proteinprotein interactions in plants sumo is essential during seed development modulates hormone signaling and bioticabiotic stress responses several studies point to a nuclear enrichment of sumo conjugation machinery which is consistent with a preferential nuclear localization of the sumo targets nonetheless nonnuclear targets exist and the molecular mechanisms that mediate their modification remain elusive dr loiss group has uncovered a novel regulatory mechanism consisting of the processing of the cterminus of the sumo e1activating enzyme large subunit sae2 processed sae2 partially localize to the cytosol and the processing activity is prominent at the transition between embryo growth and seed maturation accumulation of sae2 in the cytosol promotes cytosolic sumoylation and behave as a signal for growth arrest suggesting that sae2 processing could contribute to finalising embryogenesis sumocell aims to uncover the signals that trigger sae2 cytosolic localization and the cellular responses activated by cytosolic sumoylation first with duke university partner we will study sae2 subcellular dynamics using superresolution microscopy under hormone treatments and stress challenges second we will study the physiological processes regulated by sae2 localization to the cytosol for that we will perform singlecell rnaseq studies from cells enriched in cytosolic sae2 bioinformatics analysis will be carried out by a placement at sequentia sl finally we will analyse physiological parameters related to seed quality data obtained from cell studies transcriptomics and seed performance will be integrated in a signalling model to understand the role of cytosolic sumo conjugation in seed development providing a multidisciplinar training program
molecular design of electrically conductive covalent organic frameworks as efficient electrodes for lithiumion batteries

a major breakthrough in chemistry and materials science has been the development of lithiumion batteries libs which show great potential for storing energy from renewable sources and as the power sources for electric cars however commercially available libs are based on transition metal oxide cathodes presenting limited energy density and raising relevant environmental concerns organic materials have received much attention as alternative electrodes because of their high theoretical capacity resources availability and sustainability in particular covalent organic frameworks cofs have emerged in the past few years as promising organic electrode materials due to their high stability high ionic conductivity and outstanding chemical and structural versatility low electrical conductivity remains the main bottleneck for real applications of cofs as electrode materials usually addressed by adding in large amounts of conductive carbon additives that decrease the energy density of the battery the overarching objective of this project is to design and synthesize new conductive redoxactive cofs as cathode materials to enhance libs electrochemical performance the specific goals are a to design a new family of stable redoxactive cofs built from unexplored building blocks to achieve an optimal balance between capacity electrical conductivity and porosity b to investigate the role of the linkages building blocks doping pressure anisotropy and morphology on the electrical conductivity unravelling the fundamental mechanisms of charge transport in cofs c to manufacture and test lithium batteries using conductive cofs cathode materials assessing the influence of the processing techniques on the electrochemical performance
new carbohydrate oxidising enzymes prepared by directed evolution and their application in synthesis of aminoglycoside derivatives with antibiotic potential and rare sugars

carbohydrateoxidising enzymes coe are a group of enzymes which are active on specific carbohydrates and can use molecular oxygen as a mild oxidant oxidation is typically directed towards specific positions of the sugar ring regioselectivity and substrate specificity relies on the architecture of active site therefore the direct evolution approach in this project will allow to generate a toolbox of effective and regiospecific catalysts to modify various carbohydrate scaffolds our aim is to use this toolbox to generate a library of bioactive compounds i aminoglycoside derivatives starting with analogues of kanamycin as candidates to help in the fight against the global problem of antimicrobial resistance this process in combination with a further chemical step may lead to a large library of derivatives prepared in short time with only a twostep chemoenzymatic process ii rare monosaccharides and oligosaccharides as promising candidates with health benefits antimicrobial activities of prepared library of compounds will be measured and statistically evaluated furthermore this project will advance the current knowledge of coe which is of utmost interest for fundamental biology and crucial for industrial biotechnology and chemistry applications biocatalysis will be applicable to the synthesis of a wide range of saccharide related compounds solving one of the big challenges in carbohydrate chemistry the regioselective differentiation of the oh groups in a green sustainable and very efficient way
how migration decisions are made diverse aspirations trajectories and policy effects

the eu and its member states pursue a wide range of policies that address migration including development cooperation border management and legal labour market access to be effective policies must be based on an accurate understanding of how individuals decide whether to migrate dynamig will fill critical gaps in scientific and policymakers knowledge about how the decisionmaking behaviour of potential and actual migrants interacts with policies given micro meso and macro factors eg different socioeconomic status we focus on africa as the most important future region of origin for migrants to europe we pursue a multidisciplinary approach along four dimensions first we extend existing conceptualisations of the dynamics of migration decisions along extended trajectories and test these through innovative methods including digital diaries collected from migrants en route from nigeria kenya senegal and morocco to europe second we develop a mobiledevicebased tool for online choice experiments to causally study aspiration formation across different contexts and stages of migration with several tens of thousands of individuals in origin and transit countries third we study how policies affect migration decisionmaking with methods that allow causal interpretation choice experiments with respondents in different contexts a randomised controlled trial of an entrepreneurship training intervention in senegal and a quasiexperimental analysis of the eutf for africa fourth through interviews with highlevel policymakers and textual analysis of policy documents we analyse how the design of eu member state and relevant african policies that address migration takes into account migrant decisionmaking to maximise our impact on policymaking we embed our research in an intentional process of joint knowledge creation with stakeholders in europe and africa including the policymaking community migrant and diaspora organisations and civil society
biobone bioactive hydrogelbased implants to induce bone regeneration

osteosarcoma and ewing sarcoma are the most common types of cancer in patients younger than 30 years the gold standard treatment is bone tumor resection followed by reconstruction of the tissue thereby allowing the salvage of the limb titanium and its alloys are mostly used in such orthopedic surgeries due to their biocompatibility and excellent mechanical properties a novel cuttingedge technology of patientspecific implants 3dimensional 3d printed porous titanium implants was recently introduced to clinical use yet even several years after surgery the resected section is not fully reconstructed leading to further medical complications often requiring reoperations a promising solution is the combination of titanium porous implants with bioactive scaffolds to support bone regeneration following tumor resection here we aim to fabricate a 3dprinted porous titanium implant incorporated with patentprotected bioactive materials we have developed in the scope of the personalbone ercstg project to provide an optimal microenvironment for stimulating bone regeneration following bone tumor resection for this purpose we will optimize the formulation as well as the method of incorporation into 3dprinted titanium implants the incorporated implants will be tested for biocompatibility and osteointegration in criticalsize bone defect models in vivo as we recently demonstrated for the novel materials we will examine several success criteria which will be refined according to input from orthopedic oncology surgeons who routinely perform tumor resections this novel technology is envisioned to significantly advance the current treatments offered following bone resection thereby considerably reducing the risk of further complications and offering a major improvement in the quality of life of patients recovering from bone cancer
kinase regulation by phase separation

protein phosphorylation is a process that activates biological and cellular pathways this process is carried out by enzymes called protein kinases that add phosphates to proteins protein kinases are crucial drug targets involved in the onset and progression of human diseases such as cancer and alzheimers disease growing evidence suggests that protein kinases are regulated spatially and temporally by the phase separation and condensation of biomolecules into cellular organelles that are not surrounded by membranes the molecular mechanisms that govern the action of kinases in phaseseparated condensates however are unknown knowledge of these mechanisms is crucial for the development of better drugs that target protein kinases to address this challenge i have designed an interdisciplinary project that goes well beyond the stateoftheart to explore in atomic detail the action of protein kinases intimately involved in alzheimers disease and the abnormal phosphorylation of the protein tau the phasekin project aims to i reveal the specificity and reaction kinetics of protein kinases inside phaseseparated condensates in vitro and in cells ii decipher the dynamic conformational landscape of the protein kinases mark2 and gsk3 by advanced nmr methods that will grant unprecedented detail on their modes of regulation iii disentangle changes in population distributions and rates of interconversion between structurally distinct kinase states inside condensates iv unravel the physicochemical basis of kinase drug partitioning into condensates the highly innovative nature of the project is devised to delve into the heart of protein kinase function and to revolutionize our knowledge about the chemistry of drugkinase interactions findings from the phasekin project will provide critical guidance in the development of more efficacious and specific drugs which target protein kinases
probabilistic decision framework for resilience assessment of offshore energy infrastructures subjected to seismic submarine landslide hazard proslide

the offshore energy infrastructure oeisoil interaction has been studied by numerical analyses in the literature however these studies are rarely focused on the performance of oeis during the seismic submarine landslide ssl moreover the pseudostatic approach employed for stability assessment of oei is generally conservative for deep water conditions the dynamic approach needs a wide range of input parameters and spends a lot of time and money on analyses accordingly predictive models are needed to fill the gap between these approaches for a simple prediction of oei deformations during ssl the overall objective of proslide is to develop a reliable and low computational cost solution for simplified resilience assessment of oeis damage due to ssls answering this concern is not trivial but it can guide future analyses and contribute to gaining insights from a calibration effort using numerical models that will be undertaken using a benchmark centrifuge model that can successfully capture key mechanisms and features as well as trends the findings will be based on a database produced via advanced numerical analyses of the oeissl mechanism using the demfem a catalog of nearfault ground motions machine learning technic and probabilisticfragility analyses a twoway transfer of knowledge is guaranteed since i have a solid background in the development of earthquakeinduced sliding models and ground motions databank and also my supervisor at aau has vast experience in the resilience assessment of oeis and datadriven models moreover my supervisors at secondments rmithkust have great experience in the fields of oei numerical simulation and physical modeling accordingly this will ensure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results the acquired skills will allow me to embrace an academicnonacademic career path in the eu