Dragon09/odtu_chatbot huggingface dataset:
music as youth empowerment creating connection to self and others

can music solve global challenges lead to improved connection and empowerment foster an inclusive society i introduce music engagement as a ubiquitous daily resource to advance a critical capacity in a modern world youth ability to connect with self and others the challenge of assessing music as a human resource is that it functions at emotional bodily and situated levels of experience that are difficult to objectively measure however such aspects are integral to stateoftheart conceptions of human cognition and further advancements in empirical research now enable their quantitative assessment in musiconnect i will conduct groundbreaking research to address the emotionalbodilysituated nature of music to conceptualize and objectively measure how when and for whom music engagement functions as empowerment three dialogical work packages will address music as 1 emotional selfregulation 2 embodied interaction and 3 situated engagement young people n 5000 aged 1525 with diverse backgrounds will participate in studies ranging from surveys to experiments i will implement and develop cuttingedge methods to quantify the unmeasurable of music ecologically valid experience sampling of realtime listening experiences physiological measures computational music feature analyses optical motion capture deep learning techniques deep pose estimation digital ethnography and psychometric assessment results will revolutionize the scientific capacity to address music engagement as testable falsifiable and evidencebased practice breakthrough knowledge will be created on the mechanisms of action through which music functions as empowerment and how the effectiveness of this is determined by the interplay of musical individual situational and cultural factors findings can advise educational preventive or social programs that aim to support youth in building their selfregulatory competence and social connections in todays world
roles of gquadruplexes in kaposis sarcomaassociated herpesvirus latent replication

kaposis sarcomaassociated herpesvirus kshv is a widespread oncogenic virus whose infection can cause kaposis sarcoma an incurable cancer frequent in immunocompromised individuals similar to other herpesviruses kshv establishes a latent infection in the host characterized by lifelong persistence of the viral genome necessary and sufficient for latent infection are the virally expressed latencyassociated nuclear antigen lana and highly repetitive gcrich sequences on the viral genome named terminal repeats trs while several studies have uncovered the importance of lana in promoting kshv dna replication and segregation during latency the essential role of the trs remains poorly understood in particular the gcrich regions contained in the trs have been speculated to fold into gquadruplexes g4 secondary dna structures that can function as replication barriers but their roles remain elusive a deep mechanistic understanding of the ways kshv maintains itself in latency would be crucial to uncover a way to eradicate the virus from the infected cells before the onset of kaposis sarcoma but this knowledge is missing mainly due to the methodological limitations of investigating kshv latent replication solely in cells with this proposal in aim to take advantage of the xenopus laevis egg extract in vitro system to go beyond such limitations and to gain mechanistic insight in the role of g4s in the latency of kshv by combining my extensive expertise in the field of dna replication with the deep knowledge of prof sara richter at the university of padua in secondary dna structures in viral genomes i aim at mechanistically defining the strategies adopted by kshv to maintain itself in latency and at identifying approaches to prevent viral maintenance in kshv infected cells the proposed project will have great societal impact on cancer prevention and it will be pivotal for my scientific and personal growth into an independent junior group leader
upscale of an innovative and sustainable biomaterial for the leather industry

turning animal skin into leather requires significant energy and harmful chemicals and releases substantial amounts of greenhouse gasses alternative synthetic leather is not an option since it is a highly polluting industry we are using biotechnology to address the development of highperformance animalfree and more sustainable materials for the fashion automotive and home goods industries we produce bacleather an ecofriendly material from microorganisms through an efficient and lowcost bioproduction and proprietary process our technology provides solutions to the problems facing the leather industry as our biomaterial has the same performances as the animal ones but are cleaner to produce independent from animals fossilderived and toxic chemicals safer to wear and ready to be used for manufacturers bacleather belongs to the nascent nextgen materials industry with a cagr of 80 annually 20202026 willingness to pay has already been confirmed with potential clients and we have established a collaboration with tempe from grupo inditex one of the most important brand footwear companies owner of zara brand among others to prepare and validate the material for its marketfit within the footwear vertical in 2022 nextgen leather was funded by seed capital investors beable to exploit the technology previously developed by patent shoessl next step to develop this innovation will be to set up a pilot manufacturing plant so we are applying for horizon europe eic accelerator calls but also we need to deploy our market positioning strategy to achieve the maximum visibility of our product and technology among all relevant stakeholders clients and the public in this sense the support offered by women techeu program will allow us that to design and execute a comprehensive communication and marketing strategy in a timesensitive manner to target both potential b2b customers as well as future investors
industry case studies analysis to improve environmental performance and sustainability of biobased industrial processes

european industries remain a significant source of pollution 51 of ghg emissions with unsustainable production processes impacting adversely on climate change natural resources availability airwatersoil quality ecosystems services and biodiversity thus a transition to a sustainable and strong bioeconomy is one of the european main priorities as part of the eu industrial policy strategy the european green deal the 2030 climate target plan and the bioeconomy strategy calimero will analyse biobased sectors industrial case studies provided by partners construction ecia woodworking cesefor textiles techtera ereks pulp paper essity and biochemicals bimkemi to find feasible solutions to improve their environmental performance while considering also economic and social aspects a deep analysis and improvement of the biobased sectors sustainability performance by sustainability experts cta weloop list ivl neovili followed by the simulation and modelling of relevant case studies through bioengineering expertise dtu will be conducted to improve current life cycle sustainability assessment methodologies based on the product environmental footprint pef guide to that end missing characterization factors to assess biodiversity loss impacts to ecosystem services and toxicity effects of sectorspecific substances will be developed the allocation methods of biotic circular systems will also be improved and the time dimension for lifecycle carbon footprint assessment will be considered material criticality and socioeconomic indicators will also be included to cover the three pillars of sustainability the improved methodology will be applied via a multi objective optimization framework that will optimize industrial simulations with sustainability criteria finally guidelines and recommendations addressed to industry policy makers and scientific community will be developed for industrial sustainable development and monitoring
understanding mechanisms of transcription factor cooperativity across scales

transcription factors tfs are critical regulators of many essential cellular functions such as the acquisition of cell identities in healthy tissues and their dysregulation in disease transcriptional activation of a gene typically requires the cooperative binding of multiple tfs that subsequently recruit various additional cofactors genomics has enabled the generation of a nearcomplete annotation of the cisregulatory elements and tfs binding them across cell types yet the precise function of each tf in the process and how these functionalities are assembled to activate transcription is an important open question here we postulate that despite strong celltype specificity the formation of tf cooperativity modules on dna relies on general principles that are shared across celltypes in tfcoop we propose to formalise these organizational rules by probing the effect of hundreds of thousands of perturbations of individual tfs on the regulatory activity of their network we will apply timeresolved nuclear depletion using optogenetics in parallel for multiple tfs of two related networks and contrast the primary effects of their depletion genomewide in a complementary approach we will develop a reductionist system to study the function of tens of thousands of individual or controlled combinations of tf motifs when inserted into the genome we will leverage the unique properties of single molecule genomics to measure the contribution of each tf to the activity of multiple components of the regulatory system across multiple loci simultaneously this will be followed by factor analysis and deep learning to integrate this large collection of primary effects of tf perturbation and identify the general principles of their assembly into cooperativity networks upon success of the project the resulting models will unlock the understanding of the genetic encoding of cellular identities and allow their manipulation for regenerative medicine
search for physics beyond the standard model with highly charged ions

spectroscopy has been a central tool in modern physics it has helped us understand atomic structure the expansion of the universe and the composition of exoplanet atmospheres today highprecision spectroscopy is one of the most promising tools for investigating some of the most fundamental open questions many theories beyond the standard model of particle physics can be tested by detecting tiny changes in atomic transition frequencies caused by the interaction with new particles new forces or the variation of fundamental constants an especially attractive target is the search for temporal or spatial variations of the finestructure constant which is predicted by several different theories highlycharged ions hcis are especially well suited for this search as they have transitions that are over an order of magnitude more sensitive to the fine structure constant than most other atomic systems the precision necessary for these measurements will soon be within reach thanks to recent demonstrations of sympathetic cooling and quantumlogic spectroscopy of hcisi propose an experiment that simultaneously probes two of the most sensitive transitions in hcis using quantum logic spectroscopy and directly compares their transition frequencies this method doubles the advantage of their enhanced sensitivities and reduces systematic effects introduced by an indirect comparison via the si second standard together these gains will allow an improvement of over two orders of magnitude on current bounds on the temporal variation of the finestructure constanti will also take advantage of the exotic nature of these extreme atoms to test further theories of fundamental physics in particular i plan to exploit their enhanced rutherford scattering cross section to determine an improved limit on the number density of proposed millicharged dark matter particlesthis data will help narrow down the most viable theories for physics beyond the standard model
panafrica network for genomic surveillance of poverty related diseases and emerging pathogens

the main aim of the proposed project is to use genomic epidemiology of tuberculosis malaria and emerging and reemerging pathogens in africa as to better understand disease etiology dynamics of disease transmission and evolution of drugresistant pathogens the study also aims to increase africas capacity in bioinformatics genomics genomics data management biobanking and promote data sharing our goal is to improve the health of africans with innovations in disease surveillance equip the next generation of african scientists with cutting edge skills and strengthening southsouth research collaborations we propose the following hypotheses 1increased capacity in genomic epidemiology will enable more effective disease surveillance in africa2increased capacity in biobanking and genomics data management and analysis in africa will enhance regional surveillance of infectious diseases and encourage timely and effective responses to emerging pathogens 3regional whole genome sequencebased surveillance will improve the detection of drtb and inform the development of more sensitive and specific rapid diagnostics for the detection and surveillance of drtb in africa and elsewhere4regional genomic surveillance of malaria parasites will inform a preemptive detection of emerging dr parasites and measure the impact of programmatic interventions for a data driven decision making by policy makers5implementation of harmonized genomic data analysis tools will allow the creation of continentwide surveillance networks able to identify crossborder spread of dr variants and emerging pathogens to achieve this pangens will develop genomic epidemiology capacity across africa by establishing a collaborative framework that brings together all expertise to perform trainings and implementation in all relevant components ranging from wet lab to bioinformatics and establish proofofconcept studies for tb and malaria in in selected partner countries
rural economy and peasant dispossession in the ottoman balkans landed estates çiftliks in manastır

ruraldispossession investigates ottoman privatelyowned landed estates çiftliks in the late 18th and late 19th century these estates were crucial to the ottoman and postottoman transition from a premodern economy to an industrial one while debates on the nature and function of these estates constitute one of the fundamental historiographical issues for ottomanists they have remained dormant in past decades more importantly historians remain in the dark regarding the phenomenons complexity and regional differentiationthe project traces the history of the balkan çiftlik in relation to the transformation of rural society peasant dispossession labor regimes and the textiles sector it focuses on the district of manastır modern north macedonia a region crucial to the çiftlik phenomenon characterized by a complex network of relations between the estates villages and centers of textile production it wıll analyze the patterns of population change to determine the extent of labor mobility between settlements especially instances of movement from villages into çiftliks and rural textile centers to identify short and longterm labor migration patterns the overall project objective is to investigate the relationship between peasant dispossession çiftlik formation and textile production archival sources include ottoman tax and property registers population surveys and court registers will be combined and analyzed via gis tools to make it possible to investigate the rural history of the district establish a comparative framework with other regions and contribute to the literature on the dynamics of the economic history of the ottoman as well as postottoman balkan world these methods will shed new light upon the çiftlik debate given that ottoman tax and property surveys have been underutilized in historiography and contain a wealth of information that promises much richer and more detailed understanding of the significance of the phenomenon
hydrodynamics of double membrane spreading in biology

eukaryotic cells exist in highly dynamic environments and are subject to a variety of existential threats ranging from viruses to pathological defects in their own genome to cope with these challenges cells have developed a conserved pathway in order to degrade harmful objects internal to the cell this process is know as autophagy autophagy involves the formation of a double lipid membrane compartment that wraps around harmful targets such as damaged organelles protein aggregates or lipid droplets in order to facilitate their degradation although the genetic and molecular triggers for autophagy have been analysed in much detail the biophysical principles governing such a dynamic process have received remarkably little attention the biophysics of autophagy is highly complex biophysical process involving the driven nonequilibrium morphodynamics of a fluid membrane that must wrap its target this incorporates molecular signalling and adhesion vesicular trafficking and active force generation and complex flows of the lipid membrane in curved geometries as well as the stokesian hydrodynamics of the embedding fluid this makes the dynamics of autophagy essentially a problem of active soft matter physicsin hydrobiomem i will build on demonstrable expertise in active soft matter physics morphology and fluid dynamics to develop novel theoretical and computational models to give mechanistic understanding and predictions of the dynamics of double membrane wrapping in autophagy i will apply these tools in close collaboration with experimentalists to test existing biological hypotheses and give new insight into this ubiquitous process in cell biology
dynamics of communities and evolution of antibiotic resistance in wastewater

environmental antibiotic resistance is a major threat to human and veterinary health and a key issue addressed by the european one health action plan against antimicrobial resistance city sewers shelter rich and diverse bacterial communities that are continuously exposed to antibiotic residues from human excreta thus becoming a reservoir of resistance predicting the risk of antibiotic resistance evolution in city sewers requires a comprehensive understanding of the dynamics and evolution of wastewater bacterial communities faced to such exposition however sewers are complex environments and contain multiple abiotic factors which may act in nonadditive ways in addition interactions between species within communities affect growth and consequently competition through both density and frequencydependent processes by changing the competitive ability of variants such as antibiotic resistant phenotypes interspecies interactions also change evolutionary processesdearwaste aims at understanding the dynamics of communities and antibiotic resistance evolution in city sewers together with establishing wastewater as a model system for fundamental studies on community dynamics and evolution dearwaste adopts an interdisciplinary approach combining highthroughput sequencing technologies environmental chemistry microbial ecology and evolution timeseries statistical analysis and formal modelling data from synthetic mesocosms will parametrize the hutchinsonian niche for population in communities a tolerance curve mapping species performance onto a complex environmental space defined by the multidimensional abiotic environment and species interactions predictions from these curves will be tested against field measurements of microbial and chemical dynamics sampled in city sewers an evolutionary experiment in similar mesocosms will finally quantify how environmental complexity and interspecies interactions modulate the evolution of antibiotic resistance
engineering of photorechargeable nanoswimmers using multicomponent heterojunctions

the realization of smart nanoswimmers capable of moving and performing desired tasks in an aqueous environment is a technological challenge due to the viscous and thermal forces exerted upon them while various types of external stimulus can be used to activate their autonomous motion light is the easiest to operate and most flexible due to the opportunities that it offers for motion modulation through intensity wavelength and direction however such optical control is affected by the properties of the aqueous media limiting the applicability of lightdriven nanoswimmers to nonscattering environments the novel approach of this project photoswim is the design of hybrid nanoswimmers that consist not only of photocatalytic but also persistent luminescent materials in order to provide triple lightresponsive lightstorage and lightemissive properties at the material level this project will explore the potential of these innovative photoactivated swimmers to 1 store and emit sufficient light energy to maintain motion in the absence of external irradiation 2 exhibit longterm luminescence for tracking purposes 3 move and interact with their surroundings at high speeds due to efficient charge pair separation and 4 achieve a major control over their motion by wavelength tunability the knowledge obtained will then be used to expand the applicability of these hybrid nanoswimmers in scenarios of limited light penetrability specifically their capabilities to maintain their photoactivity in the presence of chemical and biological interferences along with realtime monitoring of their location by the emitted luminescence will be tested in this way the potential of advanced multifunctioning nanoswimmers to keep moving and interacting with the surroundings in scenarios where the light supply is not fully available will be demonstrated
smicosmologies exploring indigenous knowledge cultures and practices of stargazing

this project offers increased understanding of arctic indigenous cosmologies as a form of environmental knowledge and traces their significance for communities in times of environmental crisis with a special focus on traditional smi cosmologies and smi contemporary art the goal is to explore and trace the appearance of human and nonhuman protagonists within indigenous stories especially about the starry polar night skies by reappearing each night these morethanhuman figures became haunting entities which provided abstract naturehuman relationships with a concrete sensual and alluring form today smi artists refer to these haunting figures to draw attention to their troubled cultural history and the present reality of climateaffected regions the integration of traditional recurring ghostly figures from smi storytelling that migrate between the celestial and the earthly as well as the human and the nonhuman stresses the urgency of changing the way humans relate to nature what is more these fascinating haunting and visionary figures provoke speculative futures in which nature is regarded as a nonhuman subject as this concept is becoming increasingly crucial in ecophilosophical debates and policy decisions on environmental justice this project aims to show that smi cosmologies especially when mediated through art can play a vital role in changing humans perspective on nature in recent years contemporary art has been called upon to give a sensual form to the abstract systematic connections of climate change the extent of the current crisis is difficult for people to grasp as a consequence art is gaining a central role within our societies it stands at the threshold between sciences politics and culture this project deals with art that is engaged in the severe environmental changes of this planet and that stands on the threshold between communicating urgency and being more than a mere messenger of environmental research