Dragon09/odtu_chatbot huggingface dataset:
unveiling the formation of massive galaxies with the james webb space telescope

the formation of massive galaxies and in particular the quenching of their star formation activity are among the least understood phases in the history of galaxy evolution it is widely thought that energetic feedback from active galactic nuclei plays a role in galaxy quenching but it is not clear how this mechanism actually turns off star formation nor whether additional physical processes such as gasrich mergers are involved moreover it is possible that not all galaxies experience the same type of quenching since recent studies favor the existence of physically distinct fast and slow quenching channels leveraging the groundbreaking observations that will soon be obtained by the james webb space telescope jwst i will test the twochannel hypothesis and identify the physical processes responsible for quenching i am the principal investigator of a cycle1 jwst program that will obtain spectra with unprecedented depth and wavelength coverage for a representative sample of galaxies at z 2 3 a key epoch for quenching using this unique spectroscopic data set in combination with jwst imaging and multiwavelength followup observations i will i derive star formation histories and quenching timescales using advanced spectral fitting techniques ii characterize the stellar populations ionized gas and molecular gas content of galaxies split by quenching timescale and identify the physical mechanisms involved in fast and slow quenching by comparing these observations to the predictions of theoretical models iii explore how the quenching processes depend on redshift mass and environment using a novel analysis of restframe colors measured from large photometric data sets this project is extremely timely and will take full advantage of the fiveyear guaranteed lifetime of jwst
targeting circadian clock dysfunction in alzheimers disease

recent nobel prizewinning discoveries on circadian clock cc have laid the foundation for groundbreaking approaches to treat many diseases including alzheimers disease ad ad is a current public health priority amplifying the demographic burden of the rising numbers of patients is the low success rate of ad therapies given that cc genes regulating memory sleep and neurodegeneration have altered expression profiles in ad cc has recently emerged as a viable therapeutic target for new effective drugs however how to develop them remains a fundamental challenge the targeting circadian clock dysfunction in alzheimers disease doctoral network tclock4ad is proposed to create a new generation of researchers able to face such challenge by harnessing neurobiology medicinal chemistry pharmaceutical nanotechnology neuroimmunology big data bioinformatics and entrepreneurship tclock4ad will exploit unique expertise and advanced technologies at 10 leading universities 3 research centers a hospital 10 nonacademic institutions including smes a large pharma company a health industry association and a patient organization across eu uk israel usa and china tclock4ad will deliver double degrees to 15 doctoral candidates with triplei knowledgeskills broad vision and a businessoriented mindset their research activities will be structured around 5 scientific themes to 1 develop novel artificial intelligence proteolysis targeting chimeras and multitargetbased strategies for new cc drug candidates 2 develop novel drug delivery nanotechnologies which take into consideration cc 3 investigate innovative in vitro stemcells 3d cultures in vivo drosophila as well as organonchip techniques for preclinical validation of cc drugs 4 get insight into the molecular mechanisms underlying cc in ad and associated drug response in mice and c elegans models 5 develop innovative biotech business model and exploitation strategies
computational design for 4d biofabrication harnessing programmable materials for dynamic preclinical cancer models

cancer is a global health burden invitro preclinical models play a key role in fighting this burden by encompassing all the activities prior to clinical trials from tumor microenvironment reconstruction to drug candidate selection however the frequent failure of promising preclinical drug candidates highlights two major drawbacks of these models i the difficult reproduction of the dynamic cancer structure related to numerous physical cues ii their experimental nature that suffers from high costs long times and limited understanding consequently the relationship between dynamic physical cues cell behavior and drug efficacy is still unknown code4bio tackles such a huge knowledge deficiency we propose a radical methodology shift to a computational approach to harness programmable materials able to change properties on demand and realize dynamic 4d biofabricated models whose stimulitriggered evolution over time 4th dimension induces targeted physical cues on cancer cells we will leverage my extensive experience with smart materials and structures to address the challenges of this multidisciplinary project specifically we will develop a computational design framework for 4d biofabrication that combines new data geometry and modelbased methods with additive manufacturing and invitro observations this framework will allow us to develop customized stimuliresponsive materials and engineer a new generation of 4d constructs with programmable mechanostructural properties and acting as mechanical regulators we will assess the constructs invitro on chronic lymphocytic leukemia to achieve a deep understanding on how complex physical cues within lymph nodes and bone marrow affect this incurable cancer in relation to chemoimmuno and targeted therapies code4bio will push the frontiers of solid and computational mechanics to unveil unconventional routes for preclinical drug screening and lay the foundation for effective dynamic cancer models
unlocking the keys to literacy phonology rhetoric and early chinese pedagogy

this project aims to provide valuable insights into early chinese literacy and education contributing to interdisciplinary studies while offering a unique perspective on the role of linguistic and phonological devices in knowledge acquisition and transmission in early china the proposed research focuses on literacy during the transition from the warring states to the han period 481 bce220 ce it investigates the complexities of early classical chinese which served as a lingua franca among intellectuals and was utilised by scribes officials and scholars it revisits overlooked aspects of early china such as childhood education and practises of literacy acquisition shedding light on the interplay between education societal structure and literary canonthe project uncovers pedagogical methodologies employed during the transformative han dynasty period elucidating strategies in literacy acquisition through the analysis of selected texts including lexicographies classics and historical records it adopts a cuttingedge interdisciplinary approach synthesizing insights from phonology rhetoric educational theories philology history and linguistics by combining close reading with digital sinological tools to analyse texts this project aims to identify recurring themes and underlying structural patterns in texts that were used as educational materials the project studies the significance of sounds pronunciation and recitation in early chinese literacy practises contributing to our understanding of how cultural prominence influenced knowledge transmission it further explores how alliterations rhymes and rhetorical devices were systematically employed to enhance the teaching and learning of reading and writing skills it also acknowledges the gender dimension examining historical gender bias in classical chinese sources and evolving roles of education for genders in early china
nearinfrared photothermal nanocar immunotherapy mediated by engineered exosomes targeted to pancreatic cancer with mutated kras

pancreatic ductal adenocarcinoma pdac is one of the deadliest cancers with a 5year survival rate under 10 current treatments for pdac are based on ineffective and unspecific drugs that cause hard side effects besides new t cellbased immunotherapies are toxic and unsuccessful in most solid tumors including pdac activating kras mutations occur in almost all patients but unfortunately kras is difficult to target this discouraging situation highlights the need to design orthogonal and innovative strategies that target different protumoral axes in order to increase the antitumor effect minimizing side effects in nirnanocar project we will develop a new concept of therapy nearinfrared nir photothermal nanocar immunotherapy nirpnci to test this concept we will fuse i thermosensitive liposomes capable to mediate photothermal therapy by nir with ii exosomes derived from mesothelincar t cells armored with il12 which maintain effector molecules from their parental cells and loaded with sirna targeted to mutated kras we will explore the antitumor capability and the tumor microenvironmentreprograming mediated by the hybrid nanotherapy in a relevant murine pdac model if successful this nanosystem will be a breakthrough with a paradigm shift in the strategy to design the next generation of nanoimmunotherapies for solid tumors
measuring the energetic cost of generating biological order

every second millions of cells go through mitosis in the human body a process dividing the cells and their genetic content in eukaryotic cells a cytoskeletal structure named the spindle apparatus is responsible for physically separating the duplicated chromosomes the selforganization of filaments microtubules and associated molecular motor proteins shape this structure for decades the dynamics of active cytoskeletal matter have been investigated both in vivo and in vitro however a comprehensive quantitative understanding of the dynamics of the constituents and their energy budget remains elusivethis action aims to investigate the nonequilibrium dynamics of contractile selforganizing active cytoskeletal material through energy and order quantification and to establish a fieldbased model to describe energetics and dynamics in three dimensions
early detection molecular mechanisms and therapeutic interventions in chronic kidney disease

the objective of eliminateckd is to demonstrate that combining measures of kidney structure and function will strongly enhance detection of chronic kidney disease ckd to reach this objective i will develop a new method to quantify the number of nephrons the smallest functional units in the kidneyrationale ckd affects 10 of the global population and causes 26 million deathsyear ckdassociated costs 140 billion eurosyear in europe exceed diabetes and cancer limitations in ckd detection impede the success of emerging therapies current ckd definition is based on creatininebased estimated glomerular filtration rate which is often inaccurate due to interindividual differences in body composition and compensation for early kidney damage as remaining nephrons increase their function using a unique combination of multiomics and machine learning approaches in human cohorts and innovative animal models i will dissect pathways that drive nephron number and enable its quantificationconcrete objectives are to1 develop a highthroughput method to quantify nephron number in large human cohorts and a novel rat model of gradual nephron reduction2 construct and validate unbiased and hypothesisdriven nephron number algorithms based on kidneyderived proteins lipids and metabolites in blood and urine3 demonstrate that nephron number algorithms enable earlier and more accurate ckd detection4 provide proof of principle that nephron numbertriggered therapy prevents or halts ckdimpactthis project will lead to a new ckd classification based on both structure and function identification of mechanisms driving nephron number will boost drug development and regenerative medicine towards nephronpreserving therapies finally the concept of structurefunction relationship is relevant in many other organs brain heart my passion to beat kidney disease by innovative diagnostics drives me towards my ultimate goal to eliminate ckd
robust crisis governance in turbulent times mindset evidence strategies

the focus of european postpandemic politics is currently on enhancing system capacities for bouncing back from crisis to normalcy these efforts draw on resilience research which has become the dominant paradigm in crisis management however there are broad governance challenges that the resilience approach fails to consider centrally how can european societies harness flexible adaptation and proactive innovation to deliver effective crisis responses in situations where going back to the way things were is neither possible nor desirable and how can democratic institutions uphold core values such as democracy the rule of law and fundamental rights in the face of crisisinduced turbulence to address these challenges the robust project aims to set in motion a paradigm shift from resilience bouncing back to robustness building back better as the central principle of future crisis governance the project breaks new ground by operationalizing the concept of robust crisis governance and investigating such responses empirically we combine historical and comparative analysis at eu national and local levels to gather a multidimensional data set out of which we identify the configurations of factors that drive or block robustness in crisis governance the project studies responses by eu institutions and eight european countries to three recent crises the financial refugee and covid19 crises to understand general patterns in systemlevel crises response while we also conduct indepth studies of localized covid19 responses on the streets of 16 european localities to understand how eu national and local crisis responses interact and are experienced by citizens on this basis the project delivers the elements of a new mindset along with policy recommendations for enabling the robust crisis governance of the future all anchored in a learning hub that will serve as the social engine of the paradigm shift envisioned by the project
forged memories the church of late antique iran and the west the textual construction of a relation with the western church and state through hagiographies epistles documents 4th5th century

according to a number of sources of diverse typology and different historical reliability hagiography historiography epistles ecclesiastical documents the church of the late antique iran also known as church of the east turned to the west searching for political support and ecclesiastical legitimation in these sources west is to be understood as a composite reality including both the roman political power often represented through symbolic even salvific figures constantine helena and the entire church located west of the iranian state this search for diplomatic pressure from the roman state and hierarchical legitimization from the western church particularly took place during the 4th5th century a period in which the church of iran bloomed as an autonomous entity but nevertheless a religious minority persecuted from time to time by the sasanian authorities through the edition of unpublished documents and the investigation about the reliability of known ones the project aims at analyzing the circumstances and reasons of this longedfor intervention of the western church and roman political power in both the dramatic circumstances of the persecution of christians in the sasanian empire and the internal problems of the church of east itself to what extent and in what way does the ideological and literary reelaboration affect the representation of this relation what are the narrative devices adopted and what is the role of some forged documents in that in particular the internal hierarchical controversies on the patriarchal authority should receive new light through the online edition translation and analysis of a probably fake epistolary attributed to the 4th century seleucian patriarch papa bar aggai that is eight letters exchanged with exponents of the western political and religious panorama among them eg helena mother of constantine
digitalising the pv sector for the era of terawatts

pvop aims at an innovative digitalisation of the pv sector at european scale developing and demonstrating 8 novel technical solutions that will allow to increase the performance of pv systems by 47 reduce the om costs by 32 and increase utilityfriendly integration with storage pvop rationale will be implemented on the basis of operational data record of real pv systems totalling more than 11gw advance artificial intelligence and big data methods will be developed to analyse these data together with a deep experience team to establish the causeeffect relationships in system failures there on the one hand these methods will be the core to develop the technical solutions and on the other hand open science techniques will help to identify the pv sector needs that will also be considered in such development the 8 solutions will be validated in 2 phases 1 controlled environments and 2 real pv systems this validation process will be monitored and evaluated with 30 kpis until trl 7 is reached later on these 8 technical solutions will be offered to the entire eu pv sector maximising the impact of the project and making reliable the generation of the expected electricity for longtime as a consequence of the developments and activities performed in pvop the pv sector will have the profitability necessary to meet the eu objectives producing the twh expected and being leader in the creation of an autonomous and climateneutral energy system
achieving remediation and governing restoration of contaminated soils now

soil contamination is a severe hazard to humans and the environment we propose achieving remediation and governing restoration of contaminated soils now aragorn through development and implementation of a complete framework the framework starts from the identification of contaminated sites and presents a decisionmaking tree to identify remediation and restoration strategies and contribute to the aims of the eu soil strategy the framework is grounded in scientific progress and adapted to fully support public and private land managers to take effective actions to protect remediate and restore the environment on europes polluted soils aragorn will provide better insights into contaminated sites and improve remediation and restoration decisionmaking by implementing robust mapping and monitoring tools that are fitforpurpose and covers a wide range of contaminants neglected hotspot polluted sites will be identified by fitforpurpose monitoring and decision strategies this will enable public and private stakeholders of contaminated sites to move from regrettable remediation to restorative remediation aragorn will compile and test remediation strategies and sustainable soil decontamination solutions and will develop and put in practice naturebased solutions improve knowledge on biodiversity and deliver a framework for stepbystep decision making in terms of what is the best approach for resilient restoration in various european countries the complete framework will be developed together with strategic engagement of land managers throughout europe and by rooting knowledge through cocreative processes and sustainable infrastructures the implementation will be done through a strong team of multidisciplinary scientists and practitioners with ongoing commitments with a diverse set of stakeholders across europe at the local national and eu level we will interlink land managers and sectors across europe to take effective action on soil health and provide longevity links and support to several eu policy and international commitments
inclusion of skilled spouses in the labour market

the rapidly changing demographic composition in europe characterised by an aging population and a decrease in birth rates poses significant social and economic challenges for european states eg not having a younger population in the labour force and increased pressure on health services by the older population attracting highly skilled migrants hsm has become an essential means of addressing these challenges and a number of countries have adopted strategies specifically targeted at attracting and retaining hsm the project investigates the facilitators and impediments to the labour market inclusion of highlyskilled migrant spouses hss through a comparative perspective of italy and norway at the macro level i ask rq1 what are the policies practices and programmes that focus on including hss in the labour market and how well tailored are they to the needs of hss at the meso level rq2 what is the role of employers employment agencies and rightsbased organisations in addressing the challenges that hss encounter finally at the micro level rq3 what career adaptability strategies do hss develop to overcome the difficulties in finding and retaining jobs the methods employed include semistructured interviews with hss employers employment agencies employee associations practitioners and political decisionmakers combined and triangulated with policy document analysis the research findings will lead to policy recommendations as to how hss can be better included in the labour market in italy norway and europe at large
2dpilot line

building on the foundation of the 2dexperimental pilot line project 2depl the 2dpilot line project 2dpl has the ambition to further strengthen the european ecosystem in the development of the relevant integration modules for offering prototyping services in the field of photonics and electronics working on the maturation of the technology and providing essential information aiding industrial uptake the main objective of the pilot line is to further mature 2dm fabrication in an industrially relevant fab environment to secure the 2d pilot line access the service offerings include the preparation of relevant process design kits pdks and multiproject wafer mpw run offerings which are an essential part of this projects outreach plan the large application space for 2dm and the broad differentiation for material property requirements make the development of such a pilot line very challenging therefore within the scope of the 2dpl project the focus for module maturation is tailored towards the photonic and electronic devices and circuits reaching academic institutions research centres smes and larger businesses