Dragon09/odtu_chatbot huggingface dataset:
precommercialization of circadian clockdrug interactions screening tool for therapeutic applications

circadian clocks carry an immense importance to human health as clock disruption is related to various malignancies from sleep disorders through diabetes to cancer furthermore many drug targets are influenced by circadian clocks in order to maximize drugs efficacy while minimizing side effects it is necessary to consider the drugs timeofadministration also known as chronotherapy these revelations are critical for drug administration and development however their practical implementation is tempered by the lack of suitable research tools that bridge the gap from the bench to the clinic the timedependent effect of an intervention on the clock is represented by the phase transition curve ptc ptcs retrieval is laborious and challenging consequently they were mostly overlooked in the pharmaceutical rd process in the erc project circommunication we studied clockresetting mechanisms which led to the development of circascope an efficient highthroughput methodology for highresolution ptc construction circascope can be used as a powerful screening method for clockmodulating drugs either for the purpose of targeting pathologies associated with circadian disruption or to identify drugs which elicit unwanted sideeffects on the clock once fully developed and systematically integrated in chronomedicine circascope has the potential to improve drug discovery and yield medicines with better therapeutic indexhere we detail our plan for the first steps toward commercializing of our innovation we will demonstrate the applicability of this approach through drug libraries screens and expand the repertoire of cell types that the system relies on in addition we will explore different commercialization strategies and interact with potential stakeholders and endusers given the medical importance of circadian effects wed envisage that circascope will become as a goldstandard procedure in future drugs development
the scaleup of the biomilk platform the revolutionary approach to manufacturing of biopharmaceuticals

biosourcing has developed a biomilk platform a new paradigmshifting technology to produce biosimilar molecules in the milk of genetically engineered goats this breakthrough development producing genetically modified goats using crisprcas9 produces 100 pure progeny of goats with genes of interest of biosimilar our bioproduction method is up to 5x more costefficient reducing costs from 100200 of to 25 per gram of api and has 10x less capex reducing investment costs from 200300 million to 35 million and 1000x lower co2 footprint reducing it from 25t to 5 per kg of api compared to conventional methods allowing its scalability and industrialization with significantly less carbon footprint the biomilk platform has the potential to be market creating and disrupt the biotherapeutics manufacturing and biosimilar markets with an enormous market opportunity of 100b the main goal of the project is to successfully complete the nonclinical analytical studies for three biosimilars with the highest market potential and perform the phasei clinical validation of the first biosimilar this will help biosourcing to close a licensing deal for the sales of the biosimilars to a pharma or biogenericproducing company by 2027 biosourcing will remain the exclusive producer and act as a supplier of api to its customers who will sell fully formulated biosimilars biosourcing is expected to receive upfront payments and milestones 40m in total per biosimilar and generate longerterm revenue through sales of api and royalty payment on net sales 5 biosourcing seeks eica blended finance 25m grant and 10m equity which will enable biosourcing to reach its value inflection point of successfully completing the important phase i study for the first biosimilar from the biomilk platform for human health application
singleatom photocatalysts enhanced by a selfpowered photonic glass reactor to produce advanced biofuels

the increasing energy demand and the depletion of fossilfuel reserves threatening our energy security and the environment have aroused intense global concern to mitigate this the eu aims to become climateneutral by 2050 by targeting at the nextgeneration of biofuels from nonland and nonfood competing biowastes butanol buoh heavier alcohols and hydrogen h2 if produced from bioethanol are promising advanced biofuels due to their high energy content long shelflife and in case of buoh compatibility with the current engines and fuel distribution infrastructure however their production faces challenges due to the low yields and selectivities during ethanol reforming glasafuels envisions a holistic approach to transform bioethanol to advanced biofuels employing recyclable and cooperative catalysts from earthabundant elements the concept is based on the engineering of a lighttrapping and lighttuning photonic glass reactor selfpowered by a thermoelectric module and tailored to amplify the effectiveness of photoamplified singleatom catalysts glasafuels aims to harness the full power of the lightactivated carriers of photoactive supports by channeling this energy to the surfaceexposed transition metalcation single atom sites there via the effective coordination with the reactants and energy matching with their frontier orbitals solar energy to fuel conversion can be maximized metalmetal and metalsupport cooperativity charge transfer phenomena and strongly polarized oxidations states can further contribute to the required enhanced catalytic performances and difficulttoachieve key reaction intermediates to develop efficient processes for the production of advanced biofuels glasafuels will leverage in a concerted way the key expertise of five partners in materials science for solar and thermal energy harvesting catalysis laser technologies for tuning lightmatter interactions intelligent processcontrol systems
joinedup land use strategies tackling climate change and biodiversity loss

urgent and concerted action can stop and reverse unsustainable land use and the overexploitation of land resources this will however require rapid simultaneous and coordinated action by a diversity of land use decision makers mosaic aims therefore to achieve the following objectives 1 to gain a comprehensive understanding of the motivations and drivers behind land use decisions eg cultural factors social identities cognitive frameworks market prices legal frameworks etc including their relative importance and interactions within and between relevant governance levels ranging from individual land managers to supranational organisations 2 to gain a thorough understanding of the awareness of key land use decision makers about climate change biodiversity loss and renewable energy challenges and their willingness to address these challenges3 to characterise future land use patterns based on spatial social and economic models that integrate key insights into the motivations and drivers behind land use related decisions and the result of these decisions in causing displacement effects ie indirect land use changes in other parts of the world 4 to support policy design and implementation for climate change renewable energy and biodiversity by means of innovative costeffective instruments and approaches cocreated in policy labs contributing to and elaborating on mosaics research results in a transdisciplinary way 5 to develop an interactive digital learning environment embedded within a digital toolbox comprising proven technologies and approaches consistent with longterm european sustainability goals and strategies to support land use decision processes at governance levels ranging from local to supranational scalesinterdisciplinary ssh research linked to stateoftheart land use modelling will be core to this project and will be embedded in a transdisciplinary research approach based on policy labs
syntactic functionality of motion verbs in italoromance

the project synfumir investigates functionality in syntax by analyzing complex motion verb constructions in regional italian functionality concerns various grammatical aspects of certain linguistic items that allow lexical units to be assembled together in more complex structures although it is a fundamental aspect of language its nature has not been fully understood yet crucial questions to theoretical linguistics depend on our understanding of functionality these questions will be tackled with new data from multilingual speakers syntactic functionality will be investigated by collecting new data via onsite fieldwork with speakers of southern regional italian sicilian calabrian and apulian around 300 speakers in total the considered constructions are restructuring pseudocoordination and multiple agreement constructions the main objective of the study is the development of a new theory of syntactic functionality based on the role of location as a syntactic element my hypothesis is that location plays a crucial role in functionality and noncanonical argument structure other goals are language documentation and the investigation of language contactby focusing on language contact between two or more extremely closely related languages that contain slightly different but comparable constructions the involved grammatical features will be investigated in a new way compared to previous studies on the topic our understanding of language contact microcontact and multilingualism bilectalism will also benefit from this study besides its contribution to grammatical theory this project has also a social and cultural impact on speakers communities because of the engagement of italian speakers about their dialects and the acknowledgment of regional italians as real languages it also represents an example of fruitful collaboration between different fields of linguistics theoretical syntax experimental linguistics and sociolinguistics
fourierdomain trx solutions enabling widespread realisation of 6g

firstto6g assembles european smes and leading universities to develop the globally first 6g trx technology ie data converters and corresponding subthz frontends which fulfils the extreme requirements for making 6g a widespread reality these requirements include extremely wide modulation bandwidth at high signal quality high energy efficiency and low costusing a novel breakthrough microchip architecture we will develop data converters with up to 16 ghz of modulation bandwidth with extremely low power consumption which are implemented in a commercial lowcost 22nm semiconductor technology we will also develop stateoftheart frontend technology and integrate both parts to two full trx solutions with unprecedented capabilities the trx for the frequencies 100 ghz will deliver 8 ghz of modulation bandwidth and will be realised in a monolithically integrated chip the trx for the frequency range of 130175 ghz will deliver 16 ghz of modulation bandwidth and will integrate on pcb the data converters and the sige frontends using advanced packaging technologies the dband frontend will be designed based on a fully automated design flowkey exploitable firstto6g results include designs for new technical concepts for data converters and the frontend integration of highperformance trx components in a single chip and automation algorithms for the design of frontends we will use these results to develop and directly commercialise high performance mmwave early 6g products as a basis for further research or to spinoff new businessesby making the widespread realisation of 6g possible we will enable the highly positive contribution to prosperity of society which 6g will ultimately have critical technical knowledge will be developed and exploited in europe by strongly growing smes which will grow the communication microelectronics provider landscape bolster the european microelectronics ecosystem and strengthen european technological sovereignty
using an organoid model to understand epithelial immunity in ibd

as the first line of defense against intestinal pathogens gut epithelial cells are an essential part of the immune system they may play an important role in immunemediated diseases such as inflammatory bowel disease ibd ibd is a group of disorders characterized by chronic inflammation of the gastrointestinal tract ibd prevalence is high in western countries 03 in 2018 and it is rising in newly industrialized countriesa prevailing model is that the interplay of two factors may cause ibd first a genetic predisposition weakens the gut immune system and causes high susceptibility to bacterial infection second pathogenic bacteria infect the gut and trigger chronic inflammationit is still unclear how the gut immune system may fail to repress bacterial infection in ibd historically most studies have been focusing on immune cells of the hematopoietic lineage such as macrophages and lymphocytes however the role of gut epithelial cells in controlling gut microbes is now gaining increasing attention in this project i propose to use organoids composed of differentiated intestinal cells to study how the intestinal epithelium responds to bacterial infection in the context of ibdi will establish an in vitro model of ibd based on human small intestine organoids i will infect the organoids with the bacterium adherentinvasive escherichia coli aiec and study how the differentiated intestinal cells respond to aiec invasion i will both test the relevance of a wellknown ibd genetic predisposition the mutation 1007fs in nucleotidebinding oligomerization domain 2 nod2 and explore novel mechanisms underlying the immune response of gut epithelial cells using rnaseq and crispr base editing my project will dissect the molecular mechanisms of ibd in addition it will improve our understanding of the immune response of epithelial cells which are an understudied component of the immune system
hb086 and hb097 for treatment of chronic sensory neuronal disorders neuropathic pain and hearing loss

hb086 and hb097 comprise our portfolio of therapeutic proteins they are a family of growth factors with actions on sensory nerve cells and represent a novel treatment approaches and a paradigm shift for medical treatment and prevention of severe chronic conditions as pain and hearing loss the drug candidates target sensory nerve cells and their support cells in dorsal root ganglia and inner ear evidence indicate a mode of action including normalisation of impaired neuronalglial crosstalk protection and regeneration of sensory nerve fibres all key biological mechanisms underpinning increased peripheral afferent drive associated with chronic pain and apoptotic hearing loss preclinical data confirm that hb086 completely abolishes pain sensation across different models and hb097 preserves the sense of hearing in relevant models importantly documented prolonged effects warrant biweekly or monthly dosing and prevention of further disease progression
recycling of end of life battery packs for domestic raw material supply chains and enhanced circular economy

batraw main objective is to develop and demonstrate two innovative pilot systems for sustainable recycling and end of life management of ev batteries domestic batteries and battery scraps contributing to the generation of secondary streams of strategically important crms and battery rms the first pilot will deliver innovative technologies and processes for dismantling of battery packs achieving recovery of 95 of battery pack components and separating waste streams including cells and modules by semiautomated processes for recycling batraws second pilot will scale and demonstrate efficient pretreatment and continuous hydrometallurgical recycling of battery cells and modules including innovative steps for cgraphite al and cu separation from black mass and mn extraction achieving a recovery of the full range of battery rms co ni mn li cgraphite al and cu at selectivity of 9098 innovations wil be scaled and demonstrated in a pilot systems with recycling capacity of 1 ton lithiumion battery lib packs dismantled per shift 8 hours and treat 300 kg bm per day batraw outcomes are of strategic importance within the prospects of the exponentially growing eu battery market and reducing eu import dependency of crms the project will further promote the overall sustainability and circularity of battery products and raw materials by developing new procedures for battery repair and reuse enabling faster diagnostics and conversion of ev packs into second life batteries delivering ecodesign guidelines for battery manufacturing demonstrating blockchain platform for raw material tracking and supply chain transparency battery passport and delivering guidelines for safe transports and handling of battery waste the project aims to maximize market uptake and impact through ambitious cde plan including circular business models innovations workshops dissemination in eu platforms policy briefs and other strategies to reach markets and stakeholders
stratospheric composition in a changing climate drivers and mechanisms

progress towards more useful and accurate weather and climate predictions requires identifying predictability sources as well as constraining the circulation response to climate change while the stratosphere plays a key role in these aspects efforts have largely focused on dynamical aspects disregarding its chemical composition ozone and water vapour largely determine the stratospheric chemical composition but also protect the biosphere from harmful uv radiation and contribute to the greenhouse effect despite advances in understanding the effects of antarctic ozone depletion and recovery impacts in arctic and global stratosphere are not understoodthis is due to limited understanding of the complex interactions between stratospheric composition and circulation and their poor representation in models the soclim project will provide new understanding of the role of stratospheric ozone and water vapour as 1 source of predictability on subseasonal to seasonal s2s timescales 2 drivers of atmospheric circulation and 3 radiative effects on global climate by using theory observations and models we will develop for the first time a chemistryweather predictionsystem to assess impacts on predictability then we will use two independent chemistryclimate and other ipcc models to quantify impacts on climate change via the influence of stratospheric composition on the atmospheric circulation response lastly we will determine its contribution to global warming in a range of scenarios from unabated emissions to mitigation via geoengineering soclim will provide new processbased understanding of stratospheric composition feedbacks on regional and global climate for a range of timescales never explored before if successful it will contribute towards reducing uncertainty in weather and climate predictions providing better constraints on the climatic impacts of anthropogenic emissions and delivering crucial information for future emission policies
multilevel approaches to understanding chronic inflammatory diseases

the mapid project aims to deliver an eastwest europeintegrating training programme for phd students focused on tackling one of the most challenging complex and therapeutically unmet problems which are chronic inflammatory diseases mapid will train chronic inflammationoriented researchers to become leaders in the field in regional national and international arenas within the doctoral programme 13 dcs will conduct their research under the supervision of prominent specialists from the faculty of biochemistry biophysics and biotechnology jagiellonian university in poland ju in collaboration with international partner academic institutions and biotech companies mapid focuses on multilevel approaches to understanding chronic inflammatory diseases including infectious autoimmune allergic disorders and cancer to achieve this goal the programme will establish and strengthen ties and collaborations between ju and top universities and nonacademic partners in europe and beyond mapid aims to foster interdisciplinary research spanning molecular cell and structural biology biophysics chemistry pharmaceutical sciences and bioinformatics with a significant contribution of omics data sets the training will give the dcs a detailed insight into the strategies and mechanisms required to contribute to growth in the sector of academic and industrial research related to chronic inflammatory disease research and development the training will include courses conducted by both host institution researchers and visiting scientists from worldleading universities and companies some of the courses offered for dcs created specifically for mapid will be accessible to other ju researchers enriching the learning resources available to them therefore the mapid will have a significant impact on the ju community and its public image enabling ju to strengthen its position as a leader in chronic inflammationrelated research in central europe
distributed multisensor systems for human safety and health

we are surrounded by a variety of moreorless intelligent technical devices designed to serve you us orothers applications onin your mobile phones wristworn health sensors on your wrists autonomousvacuum cleaners robots on the factory floor and increasingly autonomous cars all pledge to ease yourtasks and keep usyou safe and healthy sthe seamless interplay with these devices gets gainsmoreimportane as these devices proliferate and grow in t with the increased autonomy and pervasive presenceof the devices we expect continuously available support fromin the services they provide yet we wantthem to disappear unobtrusively in the background when not neededin order to provide support in a collaborative environment with human physical and digital players thetechnology needs to be equipped with senses to grasp human presence their mental and physical state theiractivities and their intentions this is required to ensure human safety safeguard their health and allow fornatural interactionthis project intends to improve sensing of human presence behaviour and health in a collaborativeor common environment by means of multisensor systems
singlemolecule acoustophotonic nanofluidics

reading biomolecular signatures and understanding their role in health and disease is one of the greatest scientific challenges in genome and proteome biology yet complete protein analysis at the singlemolecule level remains an unmet milestone this pursuit is fundamentally hindered by the huge dynamic range of protein expression in cells and the insufficient spatiotemporal resolution of current analysis methods nextgeneration singlemolecule techniques that can precisely manipulate and sequence proteins in space and time are urgently needed to reach this goal among these nanopore platforms are at the forefront leading in terms of read length throughput and sensitivity however the major challenges associated with translocation speed control and the precisereadout in solidstate nanopore devices remain prohibitive in simphonics i will resolve these issues by developing the first integrated platform that combines nanopore transport measurements spatially modulated acoustic wavefields and singlemolecule fluorescence time traces to confine scan and optically fingerprint proteins in a noninvasive and massively parallel manner the feasibility of this method will be established by attaining three main objectives 1 confining and controllably manipulating individual molecules using acoustic nanotweezers 2 ondemand engineering of 2d material optical emitters as ultrabright fluorescent probes for energy transfer based detection and 3 identifying proteinspeptides from their optical signatures in multicolor förster resonance energy transfer fret during acoustophoresis with this powerful and unique platform i will harness the vast potential of acoustophotonic interactions in monolithic nanopore devices successful achievement of the project objectives will result in a highthroughput and nondestructive protein fingerprinting platform and signify a considerable leap forward in our quest to unravel the human proteome