Dragon09/odtu_chatbot huggingface dataset:
isosimplantable ecosystems of genetically modified bacteria for the personalized treatment of patients with chronic diseases

in isos we propose to develop the first biomedical product for the insitu fabrication and autorenewed delivery of therapeutic compounds employing complex ecosystems of probiotic genetically engineered bacteria geb integrated in a biomaterialbased bioreactor isos is designed to treat chronic diseases requiring lengthy treatments the encapsulated geb populations produce the therapeutic molecules on demand stimulated by the signals of the pathological environment within the patient ie inflammation andor reactive oxygen species bacteria populations interact among them to maintain a dynamic equilibrium of the geb species and to guarantee the survival of the drugproducing geb as long as the disease persists the geb ecosystem is designed in such a way that bacteria cannot survive outside of the encapsulating biomaterial to meet future biosafety and regulatory requirements the design and the configuration of the geb ecosystem will be personalized for each patient and it will be done using insilico tools and synthetic biologyas a proofofconcept we propose to engineer an implantable gebbased bioreactor for the therapy of the wet form of agerelated macular degeneration wamd which is caused by an abnormal production of vascular endothelial growth factor vegf this proofofconcept will demonstrate the ability of isos to replace the repeated intraocular injections of antivegf molecules current treatment with a single isos bioreactor that will enhance the therapeutic response and minimize side effects due the molecular crosstalk between isos and the pathological environment isos will establish the principles of a new generation of therapeutic products that will use recombinant probiotic bacteria strains libraries for personalized treatments with rigorous control of local drug production and efficient delivery based of dynamic variation of pathological signals
a european infrastructure for farmed animal genotype to phenotype research

this proposal describes concept development and conceptualisation of a eurofaang european functional annotation of animal genomes infrastructure to realise the full potential of genotype to phenotype g2p research across species breeds and populations of farmed animal species in europe to achieve accurate g2p predictions it is necessary to be able to refine and characterise highly complex traits as sets of intermediate informative phenotypes along the entire cascade from genome to cell organism environment population and across different environments the goal of the eurofaang infrastructure is to streamline use of interdisciplinary capabilities for g2p research in terrestrial and aquatic farmed animals and provide transnational access to all of the relevant facilities expertise and knowledge to european stakeholders this will address the need to bring together national facilities at the paneuropean level in the field of animal genetic resources phenotyping and breeding and animal health which was identified as a gap in the infrastructure landscape by the 2021 esfri roadmap the proposal builds on the foundation provided by the five current h2020 eurofaang projects aquafaang bovreg geneswitch geroimo and rumigen and connects with existing infrastructures for data management and animal agriculture in the european research infrastructure landscape the institutions and organisations involved have worldleading expertise in fundamental and applied farmed animal science and consolidated established connections to european stakeholders in farmed animal science the outcomes of this proposal will lead to better alignment of the development of the research infrastructures landscape for the advancement of excellent farmed animal science and frontier g2p research in europe and globally
economics of health care markets and innovation

medical progress over the last century has undoubtedly improved our wellbeing however the equal access to health care and its economic sustainability are challenged by the scientific revolutions of genetics the nature and extent of new risks and the growing externalities across countries that put at risk the production of health care public goods the development of new cell and gene technologies holds the potential for creating therapies for conditions like cancers and genetic diseases however the associated costs may be prohibitively high it is crucial to find ways to provide an environment where such innovations are produced in the most efficient and accessible way furthermore the incentives provided by intellectual property protection which drive innovation and measures to reduce research and development costs are vulnerable to international free riding and can be in contradiction with competition policythe objective of this research program is to conduct policyrelevant analyses that address these challengesand contribute to a better understanding of optimal public policies and regulatory interventions several research directions will be pursued focusing on national price regulation these regulations must consider potential crosscountry externalities arising from explicit reference pricing used by regulators international trade considerations and the need to collectively finance socially valuable innovations the exploration of alternative pricing mechanisms such as indicationbased pricing quantitybased pricing and exclusivity extension rules will be undertaken as potential tools to improve efficiency moreover the promotion of pharmaceuticals both by the private sector and public entities will be examined additionally the research program will involve the analysis of innovation and competition policies ranging from drug research and development projects to healthcare markets
understanding wholebrain circuits mediating fear memory attenuation

the experience of aversive events is a component of everyones lives people perceive aversive events and traumas differently but the explanation of this different perception is poorly understood at times this different perception leads to chronic fear disorders like phobias and posttraumatic stress disorder ptsd despite the high prevalence of such disorders effective treatments for traumatic memories remain scarce therefore a good understanding of the timeevolution of fear memory is necessary to clarify how different neuronal circuits are disrupted in disease states but also to set the basis for the development of unified therapeutic strategy to attenuate ptsd currently the limited knowledge of the mechanisms underlying fear memory at brainwide level is mainly due to the technical limitations in largescale analysis of neuronal activitytaggingmemory seeks to study the anatomical and functional circuitry underlying fear memory extinction reconstructing singlecellresolution maps of wholebrain connectivity the identification of this circuitry could pave the way for a better comprehension of ptsd circuitry at singleindividual level to reach this goal i will develop a new quadruple transgenic mouse model able to capture multiple memories in the same brain using this transgenic line such as preclinical model of ptsd i will reconstruct the evolutionary maps of fear memory then i will test psychedelics as new promising drugs for ptsd treatment in order to analyze how fear attenuation changes with or without drug treatment highlighting the connectivity differences that drive fear suppression finally by identifying brain regions pivotal for a successful memory extinction i will then unravel the anatomical circuits with subcellular resolution by a cuttingedge intelligent lightsheet microscopethe present action will pioneer the anatomical and functional characterization of the wellknown but poorly understood phenomenon of fear memory
noninvasive followup of urinary tract cancers

bladder cancer is the most common malignancy of the urinary tract with 573000 new cases and 213000 deaths in 2020 worldwide and affecting more men than women in a 41 ratio bladder cancer has the highest lifetime treatment costs per patient of all cancers which is mainly attributed to the intensive followup procedures of patients after diagnostics and surgery followup is made recurring to extremely invasive and lowpatient compliant tests ensure aims to validate the technological and business feasibility of the electronic nose technology developed in the erc starting grant scent by establishing the proofofconcept for the noninvasive followup of bladder cancer patients to accomplish this we will approach the project from both technical and business perspectives with a perfect synergy between the research and business teams and a close contact with clinical collaborators and stakeholders
melanosomes as cancer immune modulators a novel paradigm in melanoma immunity

despite remarkable progress in treating melanoma the most lethal of human skin cancers 50 of patients are treatmentresistant with most experiencing disease recurrence our recent unpublished clinical and experimental findings uncover new yet to be explored melanosome contributions to cancer immunity unique to melanoma melanoma retains for mostly unknown reasons the ability of its origin to produce melanosomes lineagespecific large extracellular vesicles evs containing melanin surprisingly our preliminary findings indicate that melanosomes bind and block tcell activity in a tcell receptorantigendependent manner melanosomes carry a neoantigen signature that is distinct from their cell of origin and can be recycled by stoma cells with each type endowing the melanosomes with a distinct signature which may modulate upon engulfment by macrophages the latters phenotype in relation to melanoma given our novel findings and body of literature that strongly suggest an immune role for melanosomes we here propose to comprehensively explore for the first time melanosomes effect on melanoma immunity in three directions melanosomes interaction with tcells aim 1 influence on melanoma immune recognition aim 2 and interaction with macrophages aim 3 this will be achieved by a strong research framework involving new experimental tools fresh human samples and cuttingedge invivo molecular cellular and computational models while of tremendous complexity and scale this project is set to offer new perspectives on melanoma progression and response to therapy further our novel ev concepts will greatly advance the ev field and can also be applied to other physiological systems our project will also offer the scientific community new experimental tools and omics data on melanoma evs and immunity finally our project will provide new potential therapeutic means to overcome melanoma immunotherapyresistance and block melanoma progression
bluegreen governance

the main goal of bluegreen governance is to develop innovative landsea governance schemes based on scientific evidence and societal choices the current management of oceans seas and coasts is fragmented across multiple institutional layers and policy areas and based on past experience bluegreen governance pursues an innovative approach to the governance of the seas and coastal areas that promotes integration between institutional layers and across policy sectors with a clear impact on the use of the land and the sea involves and engages citizens in decisionmaking processes while at the same time including scientific evidence responds predictively to changing physical conditions as indicated by scientific evidence as well as indigenous and local knowledge and citizen science and uses egovernance tools in support of the previous three points with this focus and approach the project responds to the need for betterinformed decisionmaking processes social engagement and digital innovation while promoting more harmonious and effective sciencepolicysociety interfaces the promotion of better sciencepolicy sciencesociety and societypolicy interactions will be embedded in the digital transformation and application of egovernance tools for codesign and service delivery bluegreen governance will implement and assess these innovative governance schemes in 8 cases across several european regions and sea basins and will draw lessons on how to trigger and facilitate effective institutional change via capacity building the cases are comunidad valenciana north adriatic the solent western scheldt oslofjord canary islands and reunion with this geographical scope the project will investigate five marine basins western mediterranean sea eastern mediterranean sea north sea atlantic ocean and indian ocean including one transnational marine basin ie the north adriatic case and one transnational river basin ie the western scheldt case
hydrogenases for large scale deployment of h2 as a circular energy carrier in industrial biotechnology based on enzymatic catalysts

rapid transition toward the use of renewable energyefficient and recyclable resource is needed in industrial biotechnology to achieve sustainable production of chemicals however enzyme based biocatalytic processes still mostly rely on fossilsourced or carbon rich reactants efficient scalable selective and robust catalysts are needed to deploy h2 as a clean circular and renewable reactant in industrial biotechnology our recent breakthrough in making robust and scalable hydrogenases natures highly active catalyst for h2 oxidation and h2 production opens the possibility to meet the industrial requirements in terms of i compatibility with biocatalysis ii circular chemistry and iii economic and technical competitiveness over fossilsourced reactants the overarching aim of circulh2 is to demonstrate the successful development of one or more highly robust and scalable hydrogenases for use of h2 that selectively drives biotransformations of biobased materials to specialty and commodity chemicals in an industrial environment trl6 modelling of the reaction processes and lifecycle assessment will deliver a full quantitative evaluation of the performances and applicability of the hydrogenasebiotransformation systems this will provide convincing evidence for the adoption in industry circulh2 will deliver a scalable and robust h2driven biotechnology compatible with the existing infrastructure that will advance european competitiveness in the sustainable and circular production of chemicals it will minimize energy usage by having negligible resource losses and minimal downstream processing due to its highly selective hydrogenase catalysts the circulh2 technology aims at replacing the heavily used legacy methods of chemical production and enable decarbonization of industrial biotechnology
avatar agency moral responsibility at the intersection of individual collective and artificial social entities in emergent avatar communities

this project investigates how avatar agency impacts practices of ascribing moral responsibility in emergent avatar communities metaverse augmented metaverse and humancybernetic avatar societies these communities challenge traditional frameworks of agency and moral responsibility the unprecedented persistent and continuous use of multiple avatars by both humans and organisations has the potential to permeate prior boundaries of the physical the augmented and the virtual world we propose a dynamic normative framework of ascribing moral responsibility that is grounded in a philosophical conceptualisation of avatar agency this framework considers the way interactions between avatars individuals and organisations generate intertwined and mutual ascriptions of moral responsibility potentially enhancing or on the contrary diminishing human agency and responsibility in emergent avatar communities we construct our approach along five main objectives 1 to clarify avatar agency and related responsibility pertaining to individual organisational and artificial members of emergent avatar communities 2 to delineate the way avatar agency enhances or restrains individual agency and responsibility 3 to correlate the way interactions between social entities in avatar communities generate mutually enhancing or perhaps decreasing ascriptions of moral responsibility to all participants 4 to evaluate the extent in which the ethical characteristics of the community environment can generate normative attributions of responsibility 5 to project normative evaluations of blaming and praising practices in avatar communities the successful delivery of this ethical framework is an original contribution to the problem of moral responsibility and bears direct implications for future regulation impacting societal moral practices of accountability and blaming
novel electroactive polymeric materials for dielectric elastomers actuators and soft robots

interfacing between humans and machine using the sense of touch through haptic devices is becoming increasingly important for consumer electronics robotics medical and automotive applications one bioinspired way to achieve this is by developing soft haptic skins that can both part and receive information through touch however developing soft haptic skins which have a significant tactile response and are robust enough for daily use in heavy use consumer applications is challenging our approach uses novel selfhealing elastomers to create haptic skins in the form of dielectric actuators by combining the selfhealing elastomers with custom design approaches we also show higher spatial resolution and a larger tactile response in comparison to existing approaches this allows for the creation of transparent highly stretchable and selfhealing haptic skins opening up their use in far more heavy use domains the market for haptic devices is large and is estimated to reach 4 5 billion by 2026 this is particularly driven by the need for novel machinehuman interactions in the automotive industrial machinery and medical industries these market segments require reliable robust haptic skins which can withstand high usage whilst providing a strong tactile response we believe our haptic skin will allow for implementation and use in these high value target markets allowing for haptic skins to be used in a wide range of new and exciting application areas the aim of this project is to bring our haptic skin to market by performing market studies to quantify the economic margin and identify most promising markets establishing links with industrial partners and customers developing and optimizing haptic skins for robustness and tactile response to meet the demands of industry partners running user studies using the proofofconcept devices to benchmark and establish the benefits to industry
a european multidisciplinary clinical project meant to improve the management of patients with poor prognostic ovarian cancer after neoadjuvant chemotherapy restoring hope salvaging lives

the standard medicalandsurgical treatment of ovarian carcinoma patients relies on a systemic chemotherapy carboplatinpaclitaxel a tumor debulking surgery meant to be complete no postoperative residual lesion and a subsequent maintenance treatment with modern targeted agents recent studies identified a patient population 14000 patients year in europe whose prognostic is poor 5 yearoverall survival os 20 due to a refractory cancer characterized by a poor chemosensitivity assessable online with the numeric ca125 kelimtm score 10 and by a disease found nonresectable disease after 34 cycles of chemotherapy in these patients there is a high uncertainty about the best treatment adjustments to apply salvovar is a european project led by hcl meant 1 to raise the physician awareness and propose practical and affordable diagnostic tools for identifying these patients and 2 to assess the utility os benefit acceptability qualityoflife patient perception and affordability costeffectiveness including country coverage policies of solutions based on adjustments of their medicalandsurgical treatment these solutions implementable in routine may improve their prognosis according to recent literature data the project will be based on a large pragmatic randomized phase iii trial sponsored by arcagygineco group and activated in 6 countries engot network 100 recruiting centers with the objective of demonstrating an os benefit with the chemotherapy densification weekly carboplatinepaclitaxel dosedense regimen compared to the continuation of the standard 3weekly regimen total 685 patients treated with the standard neoadjuvant chemotherapy will be prescreened to randomize 240 patients dissemination and communication will be carriedon to ensure the quality of the project and inform the stakeholders patients public health authorities payers of the project outcomes mean to change the practices this action is part of the cancer mission cluster of projects on diagnosis and treatment
irb barcelona international phd programme on target for highimpact biomedicine

irb barcelona irb is an independent nonprofit research centre engaged in basic and applied biomedical science the irbtarget doctoral programme brings together a network of 21 institutions to implement an impactoriented training itinerary aligned with irbs strategic objective to bring fundamental science closer to applied and clinical research through two separate calls irbtarget will offer 10 fouryear fellowships to exceptional doctoral candidates who can choose and build a strong research project within one of the six interdisciplinary research nodes established at irb the selection and recruitment process will build on best practices implemented institutionwide through lessons learned in mscafunded cofund and itn projects and endorsed by the hrs4r award held by the institute since 2014 irbtarget aims to consolidate the international recognition of irbs phd programme by combining the excellence of the research and facilities offered by the institute and its 28 research groups with highly competitive employment conditions and a new holistic training and supervision strategy designed to enhance the employability of fellows and their capacity to respond to the challenges faced by the european research area in the coming years irbtarget will allow irb to set the foundations for an improved irb phd programme by integrating innovative aspects in the training of a new generation of researchers that go far beyond technical research skills and that include open science principles and research ethics gender and diversity aspects data management entrepreneurship and innovation management and communication skills aimed at engaging with both scientific audiences and the broader society irbtarget leverages the expertise of a network of partners that provide training joint supervision and secondment opportunities thereby covering the need for interdisciplinary technical skills international and intersectoral collaboration and networking opportunities