Dragon09/odtu_chatbot huggingface dataset:
lattice boltzmann for advanced simulations

the intricate dynamics of fluid interfaces disordered liquidliquid emulsions and soft microfluidic droplet crystals collectively knownas soft glass materials sgm pose challenges to nonequilibrium thermodynamics and hold profound implications for engineeringapplications such as combustion materials design and food processing advances in sgm modeling within the erc copmat projectoffer opportunities for innovative mesoscale materials in fields like tissue engineering photonics and catalysisthe lightweight lattice boltzmann lb scheme which relies on hydrodynamic moments models sgm by preventing dropletcoalescence including nearcontact interactions nci due to surfactants integrated into lbcuda an opensource software optimizedfor gpus it efficiently simulates complex flows while saving electrical energy in line with the goals of the european green dealthe lbfast project aims to optimize lbcudas implementation for hpc clusters powered by gpus achieving processing rates ofseveral hundred glups while using only 50 of computational resources resulting in a 75 reduction in energy costs compared tostandard lb methods this enhancement enables accelerated production rates for industrial applications and aligns with the criteriaof the eurohpc joint undertaking benefiting users addressing energy and environmental challenges in the next exascale computinggeneration
innovative photoactivated ruthenium chemotherapy to treat eye cancer

uveal melanoma um is a rare tumor of the eye
advanced manufacturing of biobased products for urban outdoor applications through innovative characterization digital technologies and circular approach

by applying a circularitybydesign approach the ambiance project aims to develop new and advanced biobased products characterized by a high or total biobased material content and taking into account the different alternatives for recirculation such as the different types of reuses remanufacturing recycling biodegradation or energy recovery to enhance sustainable models such approach will be coupled to the optimization of the mechanical properties for particular applications eg durability for outdoors urban furniture or sports and leisure products taking into consideration the whole lifecyclespecial attention will be paid to the optimization of product manufacturing of biobased materials which will require tuning of material composition and processes extrusion largescale additive manufacturing compression moulding for different biobased materials besides the use of digital twin technologies will enhance the development of materials and products and the remanufacturing of such biobased goods and it will optimize manufacturing processes and enhance production quality of such novel applications by leveraging iot and artificial intelligence technologies ambiances impact will be twofold firstly we will showcase disruptively innovative biobased products in different sectors and manufacturing processes while we will demonstrate applicability in dailylife products starring green urban areas that will lead the transition to sustainability the setting proposed by ambiance will directly result in the creation of new jobs based on new technical competences that will require specific training and upskilling while the technical developments and findings will be used to contributing to the standardization of biobased products and materials which will guarantee an effective and wide adoption for making such products the new baseline of our lives
bioinspired antimicrobial bone bioceramics deciphering contactbased biocidal mechanisms

bacterial bone infections are one of the great challenges of orthopaedic and maxillofacial surgery aggravated by antibiotic resistance a serious health threat responsible for 700000 deaths per year the recent discovery of the bactericidal properties of some naturally occurring surface topographies has opened a new avenue of research however there is incomplete knowledge of the mechanisms of action and too many unanswered questions to translate these advances into clinical use bambbi aims to tackle this challenge by developing synthetic bone grafts featuring contactbased antimicrobial properties adding antimicrobial activity to their capacity to support bone regeneration using a novel bottomup approach inspired in biomineralization routes i intend to engineer the surface of calcium phosphates with an unprecedented and fine control of nanotopography by harnessing the power of ions and organic molecules eg amino acids calcium chelators and surfactants to drive crystal nucleation and growth moreover we will further enhance the antimicrobial effect by exploiting the synergy with chemical moieties to modulate bacterial affinity for the surface andor confer additional antimicrobial properties by immobilisation of antimicrobial peptides this will provide us with a platform to study the contactbased bactericidal mechanisms in depth and unravel the role of nanotopography and surface chemistry and their interplay with the intrinsic properties of bacteria only considering all these parameters will it be possible to unveil the causes of the substantial differences in bactericidal efficacy of a given substrate for different bacteria and design more efficient antibacterial surfaces in addition to being a major breakthrough in the field of bone regeneration the progress in new methods of finetuning the nanostructure of calcium phosphates will have an impact in very diverse fields such as catalysis water purification and protein separation
the role of eef1a in synapse function maintenance and synucleinopathy

synucleinopathies are neurodegenerative conditions characterized by an accumulation of the protein alphasynuclein including parkinsons disease and dementia with lewy bodies a long asymptomatic phase precedes the onset of invalidating symptoms early diagnostics and treatments are hampered by an incomplete understanding of the pathophysiological mechanisms the host has recently identified the synaptic depletion of protein elongation factor 1a eef1a at early stage of the disease in easyfun the fellow proposes to combine state of the art genome editing with transgenic murine disease model and human induced pluripotent stem cell derived neurons to unravel eef1a function at synapses characterize in depth its alterations in synucleinopathy and question its pathophysiological role in the disease onset and progress in aim1 we shall provide a spatiotemporal map of eef1a in neurons and its depletion in pathology in aim2 we will explore knockdown and rescue of eef1a variants we will test whether eef1a depletion is necessary and sufficient to lead to all or some aspects of synucleinopathy in aim3 we will explore the functions of eef1a variants at synapse protein translation or degradation regulation of synaptic vesicle cycle spine structure and the binding partners of eef1a through proteomics we will provide insights into the alterations of synaptic functions in synucleinopathy and the role of eef1a the applicant will benefit from established protocols by the host and will bring new expertise to tackle eef1a function at synapses with unprecedented resolution and to provide new therapeutic avenues for synucleinopathy easyfun will benefit from an ongoing collaboration with pr jochen herms dzne munich germany the proposed work will expand the fellows core scientific expertise soft skills and professional network to match her plans towards an independent academic research career
study of the use of the ess facility to accurately measure the neutrino crosssections for essnusb leptonic cp violation measurements and to perform sterile neutrino searches and astroparticle physics

after the success of the h2020 esssb design study proving the feasibility of the upgrade of the european spallation source to become in addition to a neutron facility also a very competitive neutrino facility we propose here a study to reinforce and develop complementary features to this proposal in order to improve and widen the scientific and technological scopethe key objective of the h2020 esssb design study was to demonstrate the feasibility of using the european spallation source ess proton linac to produce the worlds most intense neutrino beam concurrently with the 5 mw proton beam to be used for the production of spallation neutrons after accomplishing all deliverables and the publication of the esssb cdr this is now fully demonstrated with the present design study it is proposed to take further steps towards its realization by introducing complementary studies and enlarging its scope by making studies on synergetic aspects of the projectthe esssb highlevel objectives are to study the civil engineering needed for the facility implementation at the ess site as well as those needed for the esssb far detector site study the feasibility and implementation of a special target station for pion production and extraction for injection to a low energy nustorm decay ring and to a low energy monitored neutrino beam decay tunnel for neutrino crosssection measurements study the low energy nustorm decay ring and the injection of the pions and muons from the special target station study the low energy enubetlike monitored neutrino beam decay tunnel and the injection of the pions and muons from the special target station study the capabilities of the proposed setup for sterile neutrino searches and astroparticle physics promote the esssb project proposal to its stakeholders including scientists politicians funders industrialists and the general public in order to pave the way to include this facility in the esfri list
digital innovations and diagnostics for infectious diseases in africa

the didida projects overall objective is to tackle povertyrelated infectious diseases in subsaharan africa and african islands by i strengthening the african research capacities ii enhancing technology development in diagnostics and digital technologies in africa and iii encouraging adoption of innovations by subsaharan health authorities clinicians businesses and patients for that the consortium includes leading partners from four subsaharan african countries kenya senegal tanzania and uganda one from african islands runion and the eu to reach our objectives we will implement a combination of complementary actions joint research projects on infectious diseases comorbidities humanlivestock interactions infectious diseases diagnostic technologies digital health solutions for africa and socioeconomic factors of innovation adoption by african people the codevelopment of an innovative lowcost diagnostic and digitalmhealth decision support technology and its integration into existing african digital health infrastructure clinical trials a phd fellowship for students in africa with joint phd awarding by eu counterparts research capacity building management grant writing publications etc staff exchanges training organisation of citizen and brokerage events targeting businesses and policy makers a comprehensive dissemination exploitation and communication action plan the impact of this project will be improved research technology development and manufacturing clinical trials capacities in subsaharan africa new knowledge gained on several topics related with povertyrelated infectious diseases increased international networks and reinforcement of the collaboration between africa and the eu a new lowcost diagnostics and decision support technology developed and its adoption fostered by dedicated studies and collaboration with health authorities better informed subsaharan populations about infectious diseases
modelling interscale energetics in gastrointestinal electromechanics

the migem proposal targets one of the remaining grand challenges in biomechanics the development of a comprehensive interscale thermodynamically and energetically coherent multiphysics model of gastrointestinal gi motility despite the importance of gastrointestinal disorders as a primary global health problem electromechanical modelling of gastrointestinal motility still presents significant theoretical and experimental limitations compared to more advanced fields such as cardiovascular bioengineering technical difficulties exist due to the intrinsic multiscale nature of gastrointestinal tissues the coupling of multiple cell types and roles and the combination of electrical and mechanical phenomena involving different energetic mechanisms migem has the potential to unlock new frontiers in gi research addressing several stateoftheart problems in gastrointestinal motility and opening unprecedented opportunities in novel subjectspecific therapies by adopting a rigorous theoreticalexperimental scientific approach migem will advance stateoftheart gastrointestinal theoretical modelling and experimental measurements unveiling fundamental energetic mechanisms that govern stomach and intestine motility in health and disease migem will enable the first calorimetric measurement of tissue sample from the gi tract and create a new path in biomechanical modelling by assimilating innovative data into multiscale thermodynamic models the project will create a new network of scientists with complementary experimental and modelling skills fostering crossfertilization providing seniortojunior methodological transfer and supporting gender balance the scientific experience of the pi the formal membership to the project of the abi university of auckland and the multiple scientific collaborations that the pi has engaged for many years will be the key elements to successfully carry out an ambitious and highrisk project
designing manufacturing and operating quantification of uncertainties to increase aviation safety

the main goal of demoquas is to develop an efficient framework of uncertainty quantification uq and provide holistic aircraftengine design tools ie multifidelity multidisciplinary digital threadstwins and model based system engineering mbse or model based definition mbd modalities with the capability to become uqenabled in this way it will contribute to achieving the highest level of aviation safety regarding novel propulsion technologies the project includes representation characterization and propagation of uncertainties through the life cycle phases of design manufacturing and operations applied in six industrially relevant test cases in this way it will contribute to advancing the current state of the art in uq methods by effectively improving their efficiency ie regarding curse of dimensionality for simulation time and accuracy the projects ambition is to provide comprehensive uq guidelines and enhance decision and policy making of unknown technologies development support virtual certification and ensure a high level of safety and improved risk managementto achieve its main goal the project will build on the following main objectivesperform detailed characterization of life cycle uncertainties for components and systems of components developed for a turboprop aircraft based on a hybridized liquidh2saf configurationemploy and further develop uq methods in a multilayered manner lifecycle design manufacturingmeasuring operations scalesfidelities subsystems systems systemsofsystemsdeliver an as open as possible framework that will allow integrated propulsion system design toolsplatforms to become uqenabled and increase safety and risk managementverify and validate the uq methodologies via testing campaigns up to trl5 including operational casespromote the projects benefits via targeted synergies in european national and international level
iodine fed advanced cusp field thruster for midpower

ifactmp iodine fed advanced cusp field thruster for midpower aims to develop an iodine fed thruster subsystem for the 35 kw range the activity will include work on all the critical building blocks required to enable the realisation of an iodine ep subsystem this encompasses the upscaling of the advanced cusp field thruster acft to that power range at airbus friedrichshafen and the development of the fluidic chain at airbus toulouse consisting of the heated iodine reservoir piping and flow control for the thruster as well as the neutraliser further the necessary verification and formalisation of the fluidic design and iodine handling procedures will be performed to enable the implementation and integration of iodine ep subsystems on platform level a major building block required to enable a completely iodine based ep chain is an iodine fed neutraliser for this purpose further improvements and modifications on c12a7 emitter ceramics will be performed by fraunhofer ikts in close collaboration with the iodine cathode development at airbus to validate the necessary control and operational schemes a breadboard ppu will be developed by airbus elancourt that includes all the required supplies telemetry and functionalities to enable autonomous control of the thruster subsystem to enable rapid and accurate characterisation of the developed thruster subsystems performance an optical iodine flow meter will be developed and integrated by university of pisa as currently no test facility exists to perform thruster testing at that power level a suitable iodine compatible vacuum chamber including a thrust balance and diagnostics will be developed at aerospazio this facility will enable full characterisation and 500 h endurance testing of the developed thruster subsystem to maximise the impact of the project easn will coordinate the public presence and communication dissemination and exploitation activities
urban transitions mission of mission innovation mi utm

the urban transitions mission utm mobilises decision makers across all levels of government to prioritise climateneutral and netzero pathways enabled by clean energy and systemic innovation across all sectors and in urban governanceby accelerating capacitybuilding and closing the gap between research development and deployment the mission empowers cities to adopt innovative solutions and help reach tipping points in the cost and scale of those solutions for urban transitionslaunched at cop26 the utm is one of the seven missions of mission innovation a global initiative catalysing a decade of action and investment in research development and demonstration to make clean energy affordable attractive and accessible for all the mission brokers solutions approaches and knowledge for netzero transitions at each step of a city climate action journey the work proposed aims to consolidate and capitalize on two years of achievements ensuring that the mission stays its course and remains both relevant and ambitious against the everevolving goals and challenges that sustainable urban development faces expand the utm cohort by recruiting up to 200 new cities working towards the missions goal to support 300 cities globally to be well on their way to reach netzero by 2030 strengthen capacity building knowledge sharing and technical support for new and existing cohort of cities helping cities apply the utm netzero transitions framework to futureproof their current strategies and climate plans and offering a platform to exchange robust crosssectoral and integrated solutions accelerate demonstration of innovative solutions in response to the most urgent needs and ri priorities for cities in collaboration with research academia a global alliance of partners including national governments financial institutions and private sector supporting cities to develop pilot and scale innovative solutions and approaches for urban transitions
reunir resilience enlargement union neighbourhood international relations futureproofing eu security enlargement and eastern neighbourhood policies for a new age of international relations

russias 2022 invasion of ukraine has ended the postcold war european security order creating new realities in countries neighbouring the eu and shattering illusions in several member states about the kremlins true intentions in wider europe by granting candidate status to ukraine and moldova and a european perspective to georgia the eu has rejected a russian sphere of influence and instead determined where its future borders should lie but this decision has not yet led to policies tailored to effectively respond to a geopolitical context which also sees china and other state actors competing for influence the eastern partnership still needs to be fitted with security and connectivity components in the accession process existing formats had already reached their limits with inter alia the obstructionism by certain member states that is linked to the divisive issue of eu internal reform this has cost the eu a lot of credibility in the western balkans and will take years to resolvereunir a project with 12 partners from across europe examines how the eu can strengthen its foreign and security toolboxes to bolster the resilience and transformation of potential candidate countries in a new age of international relations reunirs foresight approach takes the fundamental uncertainty and openness of alternative futures seriously adding the effects of protean power unleashed in unforeseen circumstances to a multidisciplinary approach to the research of the eus control power in relations with strategic rivals reunir empirically assesses foreign threats to the military socioeconomic and democratic resilience of 9 neighbouring countries determines capability shortfalls maps local perceptions of the eus support and political perspectives inside the eu on neighbourhood relations outlining scenarios up to 2035 reunir offers evidencebased policy recommendations to mitigate malign foreign interference and strengthen the eus external action
antibiotic lead optimization

the bacterial sliding clamp dnan is an innovative target for the development of novel antibiotics which are urgently needed to overcome the alarming antimicrobial resistance crisis in the previous erc starting grant novani we discovered a novel dnan inhibitor wamn17 with promising broadspectrum antibacterial activity including multidrugresistant mdr pathogens in this poc project we will optimize the antibacterial potency and spectrum and characterize the in vivo pharmacokinetic pk and pharmacodynamic pd properties of the wamn17 class so as to develop preclinical lead candidates for the treatment of bacterial infections especially those caused by mdr germs to achieve this goal we will pursue three main activities i design and synthesis of 2530 compounds in two rounds with modifications focusing on improving the antigramnegative activity as well as target identification through chemical probes to further validate dnan and identify other potential targets in bacteria ii evaluation of antibacterial activity target bindinginhibition and in vitro admet absorption distribution metabolism excretion toxicity characterization for all new compounds the frontrunners will be profiled for antibacterial activity against an extended panel of gramnegative and mdr clinical isolates and subjected to mode of action moa and targetidentification studies the most promising ten compounds will be submitted for in vivo pk studies and the best two lead candidates will be tested in a proofofconcept in vivo efficacy study using relevant infection mouse models iii ultimately we will file a patent to secure our intellectual property rights and continue to move this class of compounds forward into preclinical and then clinical studies in collaboration with a pharmaceutical industry partner the knowledge that will be gained from this poc project is essential to develop an urgently needed new antibiotic with an unprecedented mode of action