Dragon09/odtu_chatbot huggingface dataset:
advancing the clinical development of placental malaria vaccines in the context of capacity building and use of digital health technologies

placental malaria pm is a severe disease that affects a particularly vulnerable demographic group pregnant women the burden of disease is high threatening more than 100 million women every year and causing the death of an estimated 50000 pregnant women and up to 200000 infants an effective vaccine would be an attractive tool to control pm on its own or to complement the existing yet imperfect tools advancevac4pm will build on the success of previously conducted firstinhuman phase i clinical studies in europe and africa assessing the two pm vaccine candidates pamvac and primvac the clinical trial results demonstrated that both adjuvanted vaccine candidates are safe and welltolerated and induce good homologous immune responses demonstrating the feasibility of developing a pm vaccine however prior to embarking on costly large scale phase ii clinical trials it is essential to optimize the crossreactivity of the vaccines overall project objective is to advance the pm vaccine development and to broaden the immune response by i increasing the vaccineinduced antibody level by using viruslike particles vlp to display the pm antigens or ii by evaluating if a coadministration approach using primvac and pamvaccvlp will increase crossreactivity and crossinhibitory antibody titers these activities will be embedded in capacity building activities eg workshops training of mscphd students small competitive research grants to african early career researchers and development of immunology laboratory capacity in preparation of future pm vaccine trials digital tools will be evaluated pregnancy registers will be developed and the feasibility and acceptability of using mobile applications for tracking pregnancy outcomes will be assessed modelling the costeffectiveness feasibility and acceptability of pm vaccines will further strengthen the case awareness on the need for a pm vaccine will be raised in stakeholder engagement activities
continuous decentralized learning of iot devices behavioural profiles

in an increasingly hyperconnected society cybersecurity concerns take on a broader dimension which can impact citizens safety this has been widely recognized in the eu through specific legal instruments such as the cybersecurity act and the recent cybersecurity strategy for the digital decade the development of the iot technologies have fostered the deployment of datadriven services for everyday scenarios such as transport health and energy but have also increased the probability and impact of new cybersecurity threats recent and wellknown attacks have demonstrated the need to develop aibased techniques to identify such attacks in iot scenarios in this context the objective of this project is to build a decentralized framework to learn the iot devices intended behavior throughout their lifecycle in order to distinguish abnormal behavior that may reflect a security attack or threat the proposal will build an edgebased and federated learning architecture to enable iot devices to participate in the learning process by using lightweight security protocols this architecture will include the use of blockchain through a novel approach in which different ledgers will be interconnected to improve the performance and practicability of existing approaches furthermore the proposal will be the first effort to quantify the impact of humanmachine interactions on the devices intended behavior the project will be validated quantitatively and qualitatively to identify potential tradeoffs for its deployment in different iotenabled scenarios it will leverage the candidates extensive knowledge and experience in iot cybersecurity which will be strengthened by the host institution to improve his technical and transferable skills in a multidisciplinary environment the proposed project represents a unique contribution to reinforcing the culture of cybersecurity in the eu that will boost the candidates professional development during and after the fellowship
ambijet the worlds first and only highly effective plasmabased solution for europes 16 million periimplantitis patients urgently needing help to avoid losing their dental implant

regular dental checkups and treatments not only ensure a beautiful smile but good general health a healthy oral cavity strengthens the immune system and acts as a barrier against various heart kidney or lungsrelated diseases and diabetes there is currently no effective solution to treat the 163 mn infected dental implants eu 2019 freiburger medizintechnik gmbh developed the solution dentists are looking for a disruptive technology for highly effective infection control to fight periimplantitis ambijet is the worlds first and only plasmabased technology with the ability to kill bacteria on dental implants insitu it disrupts the statusquo of medical technologies by preventing the reinfection of disinfected surfaces and shows maximum effectiveness without side nor adverse effects pharmacological and chemical substances are no longer required ambijet reduces inflammation saves dental implants and helps patients live a healthier life
young children of disadvantaged families a comprehensive analysis of parental human capital investment and child health

promoting newborn and childrens health is a policy priority for sustainable development and the eu takes action to promote inclusive and childfriendly societies health and education systems thematic area 2 of the eu strategy on the rights of the child nevertheless within country differences exist in childrens access to essential health care especially among the vulnerable groups of undocumented migrants and children living in poverty an obvious obstacle for access to health care for the irregular migrants is lack of universal health coverage another significant determinant of restricted health care utilization of these vulnerable children is the challenges associated to the socioeconomic status of the parents there is little research to show methods to eliminate the health risks associated to displaced children and children living in poverty and to integrate them into the european health system the overall goal of youcdf is to provide a systematic and comprehensive analysis of the amount types and short and longterm consequences of parental investment to children from the perspective of health economics youcdf willinvestigate the extent to which the limitations in the household level restricted financial resources available to the main caregivers could be compensated by a universal health care systemtest the empirical implications of the model inform policy makers about the potential risks to the public health system caused by underinvestment to children and related inequalitiesyoucdf addresses one of the potential public health challenges for turkey and the eu the number of children who have limited access to nutritious food increases as a result of hosting refugee children from syria and facing increased food prices due to the war in ukraine
sr the next generation display technology that empowers users to naturally and intuitively work play and communicate in 3d without wearables

dimenco builds simulated reality technology a revolutionary new form of spatial computing that combines lenticular lightfield display technology computer vision integrated sensors and image processing algorithms to experience realistic 3d objects in a virtual environment seamlessly simulated reality enables touchless interaction with digital objects as if they were real like in virtual reality but without any wearables we license our technology to oemsodms companies like acer who just introduced to the market their first laptop built on sr it is the first test enduser product built on the mvp version of our simulated reality technology dimenco targets endusers in the design and engineering industries and the tremendous gaming market followed by the online conferencing market originating as a philips spinoff dimenco now has a team of 41 inventors hwsw engineers game developers and business managers who push the boundaries of technical possibilities
spatial planning and design with soil

spades mission is to develop test and implement soilinclusive spatial planning strategies to support the transition towards soil health in europe soil health is highly under pressure and the soils ability to perform essential ecosystem services should be improved to cope with pressures such as climate change and need such as a healthy living environment spatial planning and design are practices that when enriched by soil care can enhance the current status of soils and support societal challenges and needs while avoiding unwanted tradeoffs towards other areas generations or functions spades will therefor provide a comprehensive state of the art on both planning and design practices as on soil instruments to be able to make a transition in spatial planning and design towards healthy soils a fundamental understanding of the current mechanisms is key spades will develop integrative instruments and improve the information basis and brokerage to bring the spatial planning and design field and soil sector together this will contribute to the methodological basis spades will work in 17 pilots in 10 member states covering a broad range of land uses urban periurban and rural areas time and spatial scales and soil and planning challenges this is done together with local practitioners and policy makers to develop fitforpurpose soilinclusive spatial strategies to support different goals such as land degradation neutrality and no net land take the spades instruments will be presented in such a way manual and navigator so that they can be found by the right user at the right phase of the planning and design process and for the right purpose spades supports soil literacy by capacity building and communication dissemination and exploitation activities to a broad range of target groups to enable current practice to improve to make this most effective spades case partners are involved in these cde and training activities
awash baringo correlation and cyclostratigraphy human evolution and paleoclimate

age control is central in the study of human evolution as most if not all major hypotheses in palaeoanthropology and archaeology critically depend on it it is further generally assumed that adaptation to new environments was the catalyst to key biological and cultural innovations in our ancestral lineage however in most cases a highresolution temporal framework to test whether human evolution is driven by environmental and climate change is lacking however such a framework can be provided by astronomical dating or tuning abccycle awash baringo correlation and cyclostratigraphy therefore aims to i construct a highresolution astronomicallytuned age model for two key paleontological and archaeological localities in east africa using a novel combination of relative paleointensity rpi and rockmagnetic cyclostratigraphy in order to ii critically test if climate and environmental change controlled the distribution and evolution of hominins in the east african rift valleythis project builds upon the magnetostratigraphic expertise developed by mark jan sier mjs during his phd and postdoc as well as his privileged access to the drilled sediment cores of several localities from the east african rift valley including baringotugen hills barsemoi and north awash region mjs will provide entirely new approaches to the chronological and environmental control of this region by applying an integrated cyclostratigraphic approach for geological dating and correlation as has been developed at the department of earth sciences of utrecht university
curved optoelectronic system to monitor ocular signals

cosmos is a highly multidisciplinary project that will deliver the first technology for the continuous recording of cell resting membrane potentials biological electric fields arise by ion transport across cell membranes and tissues and represent a crucial cue in guiding cellular differentiation eg stem cells mutation eg cancer cells and migration eg wound healing however the underlying mechanisms behind these phenomena are yet to be fully discovered this is because this data is currently hard to access with existing technologies microelectrode arrays rely on electroporation ie probing the cell membrane with consequent disruption which makes it challenging to perform prolonged measurements the patchclamp method has a low throughput and novel optical technologies mainly addressed the measurement of action potentials however most cells in the human body do not fire action potentials and they communicate in a narrower electrical range cosmos will implement a platform to perform contactfree recordings of membrane potentials by optically mirroring the cell membrane charge this technology will be first applied in testing corneal regenerative technologies topical drugs limbal stem cells postcorneal transplant monitoring as corneal wounds are an excellent model to study electric fieldregulated cell behavior cosmos will provide the technological tool to enable addressing a fundamental scientific question as well as pave the way towards new diagnostic methods therapeutic strategies and in vitro drug testing platforms
observation of ecosystem changes for action

the objective and key ambition of obsgession is to monitor and predict biodiversity change and its direct and indirect drivers in terrestrial and freshwater ecosystems through the integration of stateoftheart multisensor earth observation eo data innovative insitu including citizen science data and products together with nextgeneration ecological models that account for uncertainty this aim goes well beyond the current stateoftheart in combining the various data sources modern modelling and uncertainty estimation the methodological principles include firm anchoring into science and policy needs true interdisciplinarity between terrestrial and freshwater as well as eo and ecosystem modelling disciplines and fair and open science practices including sharing of research outputs with both the scientific community and the civil society to study how biodiversity across terrestrial and freshwater domains is changing and the processes and needed innovations leading to efficient sciencebased solutions towards observation of ecosystem changes for action
the gut microbiome as a mechanism underlying predator foraging behaviour and predatorprey interactions

aposematism is a widespread antipredator defence where prey advertise their chemical defence with warning signals previous work has demonstrated high withinspecies variation in how quickly predators learn to avoid aposematic prey and this heterogeneity among predators is suggested to play an important role in the evolution of prey defences this project aims to investigate what maintains the observed variation in predator behaviour by focusing on an unexplored mechanism a predators gut microbiome evidence from humans and laboratory animals shows that gut microbiome can influence learning memory and foraging choices the microbiomegutbrain axis and theoretical models predict feedback loops between gut microbiome diet and host behaviour here i will translate this to the ecologically relevant context by 1 quantifying how the consumption of prey toxins alters the predator gut microbiome physiology and foraging behaviour 2 testing the effect of the earlylife gut microbiome on foraging behaviour and 3 determining the causal effect of the gut microbiome on foraging behaviour i will use wild great tits parus major as predators and combine several methods that include manipulating birds gut microbiome with prey toxins and faecal microbiota transplantation quantifying gut microbial compositions from faecal samples using 16s rrna sequencing and conducting behavioural experiments to test avoidance learning memory and dietary wariness the results will address the current knowledge gaps in the predatorprey field by providing insights into the mechanisms that underly variation in predator behaviour furthermore the project will advance our understanding of the ecological and evolutionary consequences of microbiomes for species dynamics this will complement and broaden the current research of the host and enhance future career prospects of the applicant by providing an opportunity to gain new research skills and expand the fields of expertise
deep learning augmented topologicallyprotected photocatalysts

sunlight as a nonstop power source granted by nature provides about ten thousand times more energy than humans consume globally therefore its harvesting and conversion to storable energy such as plants perform in photosynthesis represents a longheld dream of humanity with the rapid progress of photocatalysis humankind now endeavors to split water molecules using sunlight thus storing solar energy into clean and recyclable hydrogen gas to date the efficiency of this conversion is up to 20 but with insufficient stability in this context delatop represents an effective solution to boost solartohydrogen sth efficiency while significantly improving conversion robustnessrecently cavity chemistry has arisen as a novel path to control chemical reaction rates in the context of lightmatter interactions concurrently photonic devices with topologically protected resonances have demonstrated superior defect tolerance and lifecycle durability in this regard delatop aims to design novel photocatalytic heterojunctions endowed with exceptional photon harvesting and carrier generation rate furthermore using artificial intelligence ai for reverse engineering design the rd cycles can be significantly reduced with proper optimizations as a result the first aidesigned topophotocatalysts will be delivered conjugating highimperfection tolerance and a superextended lifetime of photocarriers 100 times ie smart management of photons and carriers for the nextgeneration of green energy technologiesthe project identifies three objectives to reach the final goal i conceive and design novel photonic solutions based on topologicallyprotected resonances to be applied in the photocatalytic context ii deliver the first aidesigned topophotocatalyst through injecting deep learning neurons into the previous design iii fabrication and characterization of topologically protected photocatalytic devices with enhanced sth conversion efficiency
scaleable highpower output and low cost madetomeasure tandem solar modules enabling specialised pv applications

solmates aims to provide a novel industrial scalable technology for producing flexible durable madetomeasure twoterminal cigseperovskite multijunction thinfilm pv modules by optimized matching of narrow bandgap cigs bottom cells on flexible substrates steel polyimide and flexible glass with high bandgap perovskite top cells a conversion efficiency higher than 30 1cm will be reached the focus on rolltoroll compatible largearea highrate deposition techniques for both layer systems in combination with the development of inline quality control units for defect detection will lead to a minimized celltomodule gap and full industrial scaleup after the project ends solmates will demonstrate a 100 cm flexible lightweight durable encapsulated monolithic interconnected tandem thinfilm module with more than 25 due to a unique serial interconnection the madetomeasure production of highlyefficient pv modules in respect to shape size and output voltage based on multijunction solar cells will become a reality the developed technologies boost the power output of flexible thinfilm pv paving the way for the uptake of long awaited applications such as integrated pv by exploiting already existing surfaces for solar energy generation landuse conflicts will be minimized and the total costs for pv can be reduced the involved innovation driven smes will cooperate with the research partners to facilitate a pathway to mass production lowcost rolltoroll fabrication of solemates pv technology and strenghten the eu pv value chain the environmental footprint of the technology which is inherently low for thin film devices with thin flexible lightweight substrates and encapsulation will be carefully assessed with respect to solmates recycling strategy possible enduse applications will be reviewed and a longterm vision focusing on the environmental social and economic benefits of utilising pv in our daily lives will be developed
intelligent new radio access network deployment and management

the fifth and sixth generations 5g6g of cellular networks have to handle an unprecedented surge in data traffic which comes as a result of the emergence of a wide range of applications notably the internet of everything haptic internet digitaltwin to name a few on one hand mobile users expect to experience highspeed and reliable wireless access at an affordable cost on the other hand service providers aim at maximizing profits and are expecting costeffective solutions from wireless industryincreasing the capacity of the next generation radio access network ngran capitalizes in a part on reducing the cell sizes and the transmissions on highfrequency bands eg millimeter wave that offer small coverage however these solutions call for a dense deployment of base stations where traditionally each comes with the expenses of establishing fiber links to the core network and a site acquisition tower lease the wireless industry leaders opt for developing flexible and more costeffective ngran that revolve around the dense deployment of lowcost radio access nodes with integrated access and backhauling iab the wireless backhaulingfronthauling feature will ease the task of iab nodes deploymentrelocation and save in the cost of the fiberbased bakchauling network although iab is an attractive solution that could make dense deployments economically viable efficient approaches for the optimization and management of the resulting largescale and heterogeneous ngran remain subject to investigation together with my supervisor prof o ercetin i will contribute to the efforts of building costeffective ngrans empowered by iab nodes in particular to the automation of the deployment operation and fastrecovery of ngrans this project investigates two overlapping and complementing research problems unsupervised planning and optimization of ngran and reliable backhaulingfronthauling wireless network for iab nodes
incorporation of mebattery project in the eic pathfinder portfolio mid to long term and system integrated energy storage

the main objective of mebatfol project is the engagement and contribution of mebatterys team to implement the activities that are part of the eic pathfinder portfolio mid to long term and system integrated energy storage mldes work package to reinforce collaboration with the portfolio projects specificallyportfolio management and internal governance elaboration of the portfolio action plan with the details of the technoscientific collaborations and synergies with other portfolio projects portfolio actions to foster innovation implementation of portfolio dissemination and exploitation activities technoeconomic benchmark and comparative assessmentreinforcing collaboration and coordination within the mldes pathfinder portfolio is not only pertinent but also mandatory as it is the main goal of portfolio building by including a broader range of energy storage technologies addition of mebattery project to the mldes pathfinder portfolio will contribute to achieve some of its main goals namely to guarantee the diversification of energy storage technologies optimise european energy storage and enable demand response strategies and capabilities to host higher penetration of intermittent renewable technologies redox flow battery technology is currently underrepresented in the mldes pathfinder portfolio with only 2 projects focused on these promising electrochemical energy storage systems to address the pathfinder challenge goals hence incorporation of the mebattery project will undoubtedly strengthen research innovation dissemination and exploitation collaborative efforts in this eu strategic field