Dragon09/odtu_chatbot huggingface dataset:
enhancing the scientific excellence of tubitak mrc mt in ceramic membrane fabrication for industrial wastewater recovery applications via knowledge transfer and capacity building

due to rising water demand and an increased focus on sustainability ceramic membranes known for their superior chemical and thermal resistance are becoming increasingly important in recovering industrial wastewater with a cagr of 119 the european ceramic membrane market is anticipated to reach 35 billion us dollars by 2030the number of projects and rd studies on ceramic membranes in turkey is quite limited there is not yet sufficient awareness about the necessity of ceramic membranes in the industry and commercial production of ceramic membranes cannot yet be carried out tübitak marmara research center mrc is turkeys leading research center producing science and technology with its research development and innovation capabilities material technologies vice presidency mt of tübtak mrc with its interdisciplinary knowledge and human capacity in both ceramic and solgel technologies can fabricate and characterize mf uf and nf tubular ceramic membranes on a laboratory scale however it has challenges regarding ceramic membrane substrate fabrication scaling up and ceramic membrane layer modification limiting the reallife industrial usage for wastewater recoverythe twinceramem aims to meet the requirements of the horizonwidera2023access0202 twinning green deal call the main objective of this project is to increase the scientific innovative and administrative excellence capacity of tubitak mrc in the field of ceramic membrane fabrication for industrial wastewater recovery applications in order to support the sustainable use of water as a natural resourcethis main goal is to be achieved with the support and mentoring of leading european partners fraunhofer ikts germany which specializes in ceramic membrane substrate fabrication and vito nv belgium which specializes in selective separation membrane layer modification
support and networks to accelerate the construction and renovation innovation track to market

startrack aims at expanding the built4people innovation cluster b4pic network developed in the he project nebula and strengthening and supporting b4pics and their members to deliver sustainable and peoplecentric innovation and accelerate uptake by regional value and supply chainsthis overarching objective will be achieved byintegrating new b4pics 6 new b4pics will be setup in regions so far not covered by the b4pic network and receive direct support outreach activities to innovation clusters will be made in order to reach the b4p contractual target of 1015 fully mature b4pics by 2028creating enabling conditions and providing tools and training for b4pics and their members for increased development and market transfer of sustainable construction and renovation innovationaccelerating the demonstration of holistic and inclusive solutions with high market potential through tailored support mechanisms incl access to demo sitesfacilitating access to funding for demonstration scaleup and implementation of sustainable innovation by localregional construction value chainspaving the way for replication widespread use of the supporting tools and services and continuous expansion of the built4people network based on a ue27 replication plan with a longterm vision and business modelin order to make b4pics attractive for different target groups of the innovation value chain concrete value propositions will be defined to highlight the impact of b4pic with respect to improvement of innovation capacities and development of sustainable business opportunitiesthe impact of the b4pic network and the b4pics themselves will be measured to show their significance for the green digital and peoplecentric transition of the built environment sector the upskilling of innovation actors and the acceleration of construction and renovation products and solutions towards climate neutrality in line with the impacts laid out in the work programme
spatialtemporal dynamics of flood resilience

existing studies on floodsociety relations overwhelmingly concentrate on risk exposure vulnerability damage loss and adaptation needs most of which adopt a negative perspective the fact that various human societies have well survived and continuously developed in flood prone areas eg coasts river deltas flood plains hilly valleys is far less studied closing this research gap requires a deeper historical perspective to investigate the resilience of human society to floods ie flood resilience and its changes the teahorse road thr area a flood hotspot across the mountainous southeast tibetan plateau is an ideal natural laboratory to study the spatialtemporal dynamics of flood resilience due to its long and uniquely documented history with extensive hazard experiences stories will set up a theoretical framework on the multispatialtemporal features of flood resilience at the thr region which covers the spatial differences household community city and region over the past 600 years regarding the governance technology society and culture perspectives of flood resilience a set of quantitative proxy data historical archives literature reanalysis statistical data observation data and field survey data will be integrated into both the empirical study in the case areas and the agentbased modelling across the cases specifically stories aims to 1 establish a theoretical understanding of the spatialtemporal scales of flood resilience 2 investigate the spatial patterns and temporal evolution of flood resilience at the thr cases 3 model the spatialtemporal dynamics of flood resilience using agentbased models 4 transfer and generalize the research findings of the thr cases to the mekong river delta and beyond by doing so stories will present pioneering work to shape the emerging research field of flood resilience offering new and multidimensional knowledge on the dynamic nature of floodsociety relations
together toward effective due diligence in minerals value chains

the european union eu under its political economic prosperity and sustainability agenda perceives due diligence dd as a means and an end dd is urgently needed for a assuring sufficient supply of raw materials primary and secondary critical for the eu industrial value chains and strategic sectors and b changing sourcing and business practices to minimize societal and environmental harm in and outside the eu in the light of the europe 2030 agenda and sdgs for that purpose the eu and its member states deployed a mix of different instruments aiming at responsible sourcing and supply chain dd these instruments cover a variety of requirements both horizontal proposed upcoming critical raw materials act and directive for corporate due diligence and corporate accountability and product or commodity specific levels ie conflict minerals regulation battery regulation these diverse frameworks of legal requirements for dd processes set and enforce standards for business regulate markets and ultimately foster a level playing field ie a state in which conditions in a competition or situation are fair for everyone even though front runner companies policy and civil society call for mandatory dd the majority of eu based companies are currently struggling to implement dd only one third of larger eu companies practices voluntary dd covering human rights and the environment while only one in seven companies claim to cover the entire value chain the dilichance project aims to fundamentally reshape the current dd operational system looking into dd solutions from a holistic threepronged approach tools business practice and assurance verification assessing their efficacy and engaging in capacity building with key decisionmakers from business and policy as well as civil society will unlock industrial leadership for key eu mineral value chains
life saving technology for thoracic trauma treatment and post operative drainage

thoracic trauma is the 1st cause of accidental death globally with a mortality rate of 60 in polytraumatic patients the time of treatment is crucial 80 of patients can be potentially saved if they are treated in 1h however current solutions to treat it are limited and static for the last 3050 years clant is a unique selffixating atraumatic and multifunctional device tackling this unmet need by offering a safe fast easy to use multifunctional and costeffective tool for treating any type of chest trauma or postoperative drainage following major thoracic and abdominal procedures it reduces the procedure time by 20x and saves up to 26bn associated with additional tube replacement euwith the eic support vigor aims to accelerate the clinical validation and scalingup of clant providing a global impact to healthcare systems clinicians and patients clant will be part of the growing emergency medical devices and the surgical drains markets total valued 40b 2030
tailored bacterial magnetic nanoparticles for biomedical imaging

of tremendous biomedical and clinical interest are magnetic iron oxide nanoparticles mnp that can be tailored to fulfil specific functions for instance as actuated drug carriers tracers for magnetic imaging modalities or heat generators in magnetic hyperthermia for cancer therapy however their use in realworld applications has been hampered by lack of precise size control and magnetic tunability as well as by poor biocompatibility associated with their conventional synthesis i propose a stepchange approach for the lightpowered bioproduction of highquality magnetic nanoparticles by novel synthetic microbes generated in ercadg syntomagx crafted precisely for their use in biomedical applications compared to commercial chemically synthesized mnp these novel bacterial mnp are expected to exhibit superior applicability and versatility owing to their genetically tuned and uniform physicochemical and magnetic characteristics available at high costefficiency and under sustainable manufacturing conditions first bacterial production and purification of the particles will be set up at large lab scale in addition their anticipated superior biocompatibility will be thoroughly assessed then we will explore and demonstrate their performance in collaboration with various biomedical end users as proofofconcept we will deliver a formulation of bacterial mnp tailored as potent tracers in highresolution magnetic particle imaging mpi with respect to the longterm goal of future commercial exploitation we will explore patenting options and thoroughly assess the demand for such high quality biogenic mnp i envision that our idea will revolutionize the biomedical mnpmarket by opening it for the wealth of genetically tailored and highly functionalized bacterial mnp suitable for a wide range of applications
dissect the impact safety and effectiveness of gene therapy at the whole organismal level by cellfree dna signatures

gene therapy gt with integrative vectors has emerged as a revolutionary intervention for the treatment of inherited and acquired disorders despite the great achievements a major challenge pertains to the heterogeneity of responses that can be obtained in patients the success of these applications critically depends on the ability of engineered cells to functionally integrate within the patients tissues to reestablish the physiological functions intrinsic features of the cellular drug product and interindividual factors present at the time or after cell infusion may modulate the clinical outcome the proposed investigation aims at characterizing cellfree cfdna signatures in patients who underwent gt epigenetic studies on cfdna will capture the organismwide changes induced by disease progression and consequent to the treatment in a noninvasive fashion furthermore the retrieval of integration sites on cfdna will provide molecular insights into the activity clonality and persistence of engineered cells in peripheral organs the translational relevance of this proposal will be directly assessed in unique clinical settings represented by patients treated with hematopoietic stem cell gt for the correction of inherited metabolic disorders and with engineered tcells to fight hematological and solid tumors by correlating patientderived cfdna signatures with clinical variables outcomes i will establish if these analyses can predict the impact of engineered cells at the whole organismal level potentially highlighting mechanisms of therapeutic success and failure that have not yet been explored the advanced knowledge gained with this project may prompt a more accurate diagnosis evaluation assist in selecting patients who will benefit from gt and provide early insights on the efficacy and toxicity of cellular therapies guiding for a more personalized therapeutic intervention to reduce interindividual variability
ferrotransmons and ferrogatemons for scalable superconducting quantum computers

we propose alternative approaches to superconducting qubit technology stateoftheart implementations require fluxbias lines to tune the qubit frequency these lines are controlled with currents which can damage qubit performance by inducing undesirable magnetic fields this is detrimental to qubit performance and presents a severe bottleneck for scalability as these lines are associated with significant heat dissipation in this project we advance two novel superconducting qubit designs capable of overcoming this challenge by eliminating the need for flux lines this will involve the investigation of sisfs junctions and their integration into quantum processors one innovation track will implement sisfs junctions in a transmon geometryferrotransmons the other will hybridize gatemons and junction to deliver a ferrogatemon three of europes leading quantum startups will integrate these alternative qubit types into prototype fullstack systems to test the implications of these novel approaches on scalability and performance quality
microbiomebased diagnostics and therapeutics

the problem much effort has been directed to identifying disease risk factors and indeed numerous genetic lifestyle anthropometric and clinical risk factors are routinely used for this task however the clinical utility of existing risk factors is limited and most of them appear when physiological derangements have already occurred the gut microbiome plays a role in human physiology and health and as such combining it with existing risk factors can lead to earlier and more robust disease detection however very few microbiomebased markers predictive of disease onset and progression were found to date and none are currently used by healthcare systemsthe solution in the ercfunded project we used our unique multiomics and longitudinally profiled 10000person cohort and biobank to develop methods for metagenomewide association studies we found microbial genetic variation at the single nucleotide level and single bacterial genes level whose baseline levels were predictive of future disease onset in this ercpoc we propose to prioritize the bacteria found in the ercfunded project wp1 and use them within machine learning disease diagnostic models wp2 that we will then license to diagnostic companies we further propose to build a microbial biobank of the ercidentified strains by isolating them from cohort participants functionally characterizing them with metabolomics and combining them into bacterial consortiums wp3 as these strains have therapeutic potential we will license them to probiotic or pharmaceutical companies wp4 notably we already validated this approach in two licensing agreements one with a japanesebased company who licensed bacteria that we found for treating atopic dermatitis and another with a us based probiotics company who licensed bacteria that we found for weight loss if successful our ercpoc may thus result in novel microbiomebased diagnostic and therapeutic products for various disease indications
bioactive multiphase membrane for periodontal regeneration

periodontitis is one of the worlds most prevalent chronic dental and maxillofacial diseases that will ultimately lead to unwanted tooth loss this disease was responsible for a significant loss of 15864 billion in europe in 2018 due to the complexity of the grafting treatment techniques the efficiency of these procedures is notably affected a bioactive multiphasic membranescaffold with different layers has been advised for this until now few commercial companies using synthetic polymers like polylactic acid pla and woven fibers made up of polyglactin 910 copolymer together with collagen have developed this type of membranescaffold however different limitations of these materials make their application difficult multiphasegtr focuses on the preparation of bioactive multiphase hydrogelbased biomembrane for periodontal regeneration the fundamental objectives of the study are i development and characterization of the two components of the biomembrane ie nonmineralized hydrogel and mineralized hydrogel membranes wp1 ii preparation of a multiphase hydrogel membrane by combining the two components ie nonmineralized and mineralized hydrogel membranes and characterization of their physicomechanical properties wp2 and iii assessment of the bioactive properties of the multiphase biomembranes in relation to periodontal regeneration wp3 finally a suitable multiphase membrane will be recommended the outcome of this proposed work not only intends to fill the current gap for the requirement of a suitable costeffective alternative to the current limited reported materials but also to elaborate the opportunity to increase the knowledge regarding the utilization of biomembrane in dental and maxillofacial tissue regeneration
is the succinatesucnr1 axis a fulcrum of cellular clocks

our circadian clock controls a wide range of physiological processes to respond to external demands through a finetuning coordination between the hypothalamic central clock and the peripheral clocks understanding the bidirectional communication and the reliance on external cues that specifically affect these clocks is of paramount importance yet both circadian clocks can function even in the absence of these external signals highlighting their endogenous nature this underscores the existence of endogenous signals such as metabolites and other biomolecules that can modulate the circadian clocks surprisingly this aspect remains largely unexplored in current researchsuccinate is both an energetic metabolic product of mitochondrial activity and a byproduct of the microbiota with critical physiological roles in cellular function at various levels furthermore in the last years succinate is emerging as a biomarker for early detection of metabolic dysfunction and cardiovascular risk as a basis for the current proposal we have recently reported via an untargeted approach that succinate regulates coreclock genes in adipocytes via its cognate receptor sucnr1 thus building upon our previous studies we propose that succinate may serve as a pivotal endogenous signal capable of modulating the circadian clockswithin the framework of this project we present for the first time the concept of succinate as a link between metabolism and circadian clocks to accomplish our goals we will employ the complementary expertise between dr fernndezveledo supervisor and renowned expert in the succinatesucnr1 axis and dr ribas candidate and expert in chronobiology by merging these two fields we aim to integrate the notion of temporality into the succinatesucnr1 axis and advance our understanding of the intricate relationship between metabolism and circadian rhythms
interoperable electron microscopy platform for advanced research and services

impress interoperable electron microscopy platform for advanced research and services aims to codevelop and deliver advanced transmission electron microscopy tem instrumentation methods and tools that will revolutionize the way in which tems are used by all new and wellestablished scientific communities integrate them with other instrumentation at analytical research infrastructures ris and create new business opportunities for small and mediumsized enterprises the core of the project is the development of a standardized cartridgebased interoperable platform for tem that is based on common interfaces and data formats is flexible and adaptable and allows users to perform advanced correlative experiments using different instruments and to codevelop methodological options that are not yet satisfied by commercially available electron microscopes the solutions will be delivered at technology readiness level 8 through a precommercial procurement the project also involves the codevelopment of new electron sources techniques based on adaptive optics and eventdriven detectors applicationrelevant in situoperando sample environments and software for simulation of experiments and remote access based on artificial intelligence by the end of the project these developments will be integrated with the new cartridgebased platform in order to make them available to all users of ris and other tems owners an open knowledge and innovation hub for tem will be created and a training programme will promote the new solution to initiate ri staff in their use and to provide both materials and life science communities with optimized tools for tackling societal challenges especially in the energy and health sectors the project will exploit synergies and collaboration with five ris of european dimension for the benefit of users from diverse scientific communities and will pave the way towards a new cooperative model for the development and operation of ris for tem
hydroxide salt energy storage innovation

hyme is a danish sme established in 2021 dedicated to revolutionizing largescale energy storage by developing a thermal energy storage tes system that stores energy in the form of hightemperature heat in molten salt this solution can contribute to the decarbonization of energyintensive industries eii and cogeneration utility companies combined heat and power plants chp producing heat and electricity from a single energy source with a tes system that is affordable compact scalable and sustainable the hyme tes system is based on a known and 20 yearproven design from the concentrated solar power csp industry which allows us to work with established suppliers uses mainly readily available system components and avoids critical raw materials and harmful substances while csp traditionally relies on nitrates as the storage medium hyme is pioneering the use of hydroxide salts which have superior thermophysical properties and higher chemical stability at elevated temperatures creating a novel tes relevant to many eiis and chp utility plants hardtoabate sectors where the penetration of green power is limited by the lack of solutions to control for the intermittent nature of renewable power sodium hydroxides high energy density brings additional advantages in terms of plant footprint mwhm2 and low total installed cost tic and its excellent heat transfer properties enable it to be used effectively in high charge and discharge capacity settings the tes system is built around our core technology a patented method for adjusting oxoacidity and its implementation limiting and controlling the corrosion of hydroxide salts on structural materials in contact with the molten salt hyme was created as a spinoff from the danish 4th generation nuclear startup seaborg aps our team comprises 35 ftes 34 of women representing a dozen nationalities