Dragon09/odtu_chatbot huggingface dataset:
twinning for excellence to advance research in the activation of antitumor immune response after electrochemotherapy combined with gene eletrotransfer of pdna encoding icis

more than a decade has passed since the first immune checkpoint inhibitor ici was approved for the treatment of advanced melanoma marking the beginning of immunotherapies in cancer treatment however even in the best scenarios with a combination of icis and standard therapies durable benefit is not achieved in about half of patients therefore new approaches are needed on how best to exploit the potential of icis the scientific aim of the zap cancer project is to determine how a local ablative technique electrochemotherapy with blm cddp or oxa induced immunogenic cell death icd can be combined with gene electrotransfer of pdna encoding icis to elicit a systemic antitumor immune response the zap cancer project plans to improve access to scientific excellence optimize research management and accelerate the exchange of personnel knowledge and ideas in the european research area era and the two participating institutions from the widening countries the institute of oncology ljubljana iolj and the faculty of health sciences fhs of university of ljubljana zap cancer will expand the existing collaborative network with three leading european institutions institute of pharmacology and structural biology a department of the cnrs ipbscnrs toulouse france katholieke universiteit leuven kul leuven belgium the institute of translational pharmacology institute of the italian national research council cnr and a new partner the medical university of graz mug graz austria through the proposed project a multidisciplinary network of cancer research centers will collaborate to establish a stateoftheart highthroughput multiomics in vitro and in vivo research platform at iolj and fhs that will provide them with valuable new expertise and knowledge that will enhance their potential for future successful applications at the european and international levels
migration affective geopolitcs and european democracy in times of military conflicts

the general objective of magnitude is to enhance citizen participation through preventing polarisation and the fragmentation of identities related to mass displacement in response to russias war in ukraine by utilizing affect as a tool tapping into the sensuous emotional and corporeal dimensions of human experience magnitude explores the consequences of mass migration caused by russias invasion for european democracy and provides evidencebased strategies to reinvigorate democratic governance in response to the negative social consequences of the war for european societies magnitude utilises the feminist concept of affective geopolitics to analyse how geopolitical narratives and imaginations shape everyday human encounters through which social political and cultural identities get constructed and contested the project explores human encounters on 3 levels 1 migrantstate between forcibly displaced people from ukraine fdps and streetlevel bureaucrats 2 migrantmigrant between fdps and migrants from belarus russia and syria and 3 migranthost societies fdps encounters with the material culture of host societies to study the affective dimension of human encounters and identities and to suggest attuned political interventions fostering democratic participation in the sensitive context of the war magnitude develops and implements an innovative affectcentred methodological framework based on sensarticulate methods encompassing artbased experiential and embodied techniques magnitude advances an innovative methodology for comprehensive analysis of the interrelations between social cultural and political identities as well as the sense of belonging and democracies eo1 which will be used to formulate policy recommendations and pilot strategies preventing discrimination alienation and marginalisation eo2 and to diffuse antagonistic identities and social norms eo3
improving quality of life of parkinsons disease patients by quantitative cognitive testing

parkinsons disease is dominated by motor symptoms such as tremor bradykinesia and postural instability however over 90 of all patients develop cognitive impairment including deterioration of learning memory and decision making current treatments focus on motor symptoms and offer at best moderate improvement of cognitive functions alleviating cognitive symptoms could dramatically increase quality of life of patients therefore we propose to apply a behavioral test of fine decision making combined with electroencephalography and electromyography measurements to quantitatively assess complex aspects of cognitive function including inhibitory control learning by reinforcement and decision making under conflict this quantitative cognitive testing qct can be employed to improve parkinsons disease therapy based on regular feedback moreover the method can be extended to other domains of neurodegenerative dementias we foresee that the application of qct can facilitate the development of telemedicine packages thus reducing hospital visits and patientdoctor contacts under this poc we propose to validate equipment we developed de novo conduct proof of concept experiments extend ipr protection and explore commercialization strategies we believe that qct can help achieve the best possible cognitive function which would improve the quality of life of patients and their families it could also reduce diseaserelated cost burden on health care systems and society making it appealing to health providers
proteinengineering based approach to detect oxidative stressinduced changes in the neuronal proteome

neurodegenerative disorders are characterised by the progressive deterioration and loss of certain neuronal populations distinct clinical features are associated with different diseases but common fundamental processes have been identified one example of this is injury via oxidative stress the production of oxidative species is linked to mitochondrial dysfunction and inflammation which have been demonstrated to occur early in these disorders identifying the proteins that are involved in the response to these species is of critical importance to understanding these diseases this will provide opportunities to identify novel biomarkers and develop treatments that are effective at these early stages the use of genetic code expansion to functionalise proteins with clickable amino acids is an emerging protein engineering technology with many potential applications in neurobiology recently it has been demonstrated that any of the 20 natural amino acids can be replaced with a noncanonical amino acid ncaa on a proteomewide scale however the application of this technology in complex cells such as neurons is still in its infancy i aim to establish a novel proteomewide ncaa incorporation methodology to monitor changes in the neuronal proteome in response to oxidative injury this will be achieved using ncaas that have been optimised for an inverseelectrondemand dielsalder click reaction which is highly biorthogonal and has extremely rapid kinetics adding a clickable biotin handle will facilitate protein enrichment in a highly timeresolved manner subsequent proteomic analysis will be applied to identify changes within the whole proteome or subsets of the proteome monitoring changes in protein expression in this way will provide valuable information about neurodegenerative disorders and allow for precise investigations of potential new drug targets and biomarkers
ecoology for galaxies using alma archive and legacy surveys

galaxy formation and evolution are intimately connected to the galaxys surrounding environment and its halo baryonic components other than stellar mass including interstellar medium ism and circumgalactic medium cgm must be better constrained in different environments in order to fully characterise the relation between baryon and halo which is fundamental concerning galaxy evolution in a cosmological contexti propose a project ecogal ecoology for galaxies using alma archive and legacy surveys that leverages the 10year repository of the alma archive to constrain cosmic molecular gas density and investigate cgm in different phases cold and hot for several protocluster systems at redshift greater than 1 with the complete dust and fir line emission catalogue from the alma archive within opticalinfraredir legacy survey fields ecogal will i constrain cosmic gas density beyond redshift 1 with unarguably better number statistics and ii build a first representative sample on cgm properties in protoclusters at z13 through carbon and carbon monoxide line emissions cold phase and thermal sunyaevzeldovich tsz effect signals hot phasewith the timely convergence with current and nextgeneration opticalir facilities jwst euclid the vera rubin observatory and a decadeold alma archive at submmmm the outcome of ecogal will produce a stateoftheart reference to studies of galaxy formation and evolution in a largescale structure the cosmic dawn center dawn and dtu space have extensive access to the most advanced opticalir facilities and extragalactic surveys and offer the necessary computing resources and research environmenttherefore they are the optimal places to carry out this project the expertise of g magdis and his group support is also essential to make this proposal successful
travelers on the margins mobility of arabicspeaking christians in the ottoman empire

middle eastern migration has always impacted european social and economic life yet eurocentrism overshadows discussions of current migration policies as well as scholarship on historical mobility while the mobility of arabicspeaking christians across the centuries to and within europe has received some scholarly attention their mobility beyond european borders is largely overlooked leading to an incomplete view of those who migrated to europe to fill in the missing pieces of the picture my project travelers on the margins mobility of arabicspeaking christians in the ottoman empire mobasc investigates the travels of this minority on the fringes of europe in the lands held by the ottoman empire 15171922 those christians who traveled to europe began their journeys within that empireindeed their mobility was often confined to its territoriesand st catherines monastery sinai served as a waystop for many as well as a destination for pilgrims this projects primary sources are notes written by these travelers on the margins of hundreds of the monasterys arabic manuscripts recently made available online these notes mainly in arabic but also in greek and syriac offer rich insights into the writers and their origins and itineraries i will collect and reconstruct the travelers accounts through their notes using my expertise in arabic manuscripts and digital cataloging and harnessing innovative approaches from micro and global history as well as social history eastern christian studies and egodocument studies and the skills i will acquire during the fellowship in digital humanities document studies and greek and syriac manuscript cultures this will enable their travels to be contextualized analyzed and compared with other mobility from the same era in particular travels that continued to europe in turn motives patterns dynamics and strategies of mobility will be revealed which can be compared to current migration patterns
footprints of ramon llulls thought in atlantic processes of evangelization canary islands congo iberian peninsula and la espaola 15th16th centuries

the project will analyse how the evangelizing method of the medieval philosopher ramon llull 12321316 has had a strong impact on the clergy during the 15th and 16th centuries throughout history llulls art of converting believers of other religions has been adapted and elaborated upon by learned clerics who were closely related to royal power in order to set the bases of the ideological legitimation for facing and conquering new lands from other monotheistic religions muslims jews as well as from gentiles canary guanches congolese caribbean tainos modern scholarship has devoted its attention almost exclusively to llulls work and thought as such failing to recognise his paramount role in later evangelization processes led by the castillian and portuguese clergythus the objectives are to describe the network of lullists working on missiological strategies in close contact with royal power their works and their relationships to make accessible and disseminate through critical editions some of the unpublished works by this lullist network to explore a first attempt of catholic globalization behind the activities of this networkto achieve these goals i will extract data from latin and old vernacular written sources while i will also unravel the philosophical concepts behind the discourses of evangelization the results will be published in a book and several articles as well as in a blog and scientific profiles in social networks freely available for the scientific community and general publicthe relevance of the project lies in revealing a so far unknown program behind all the atlantic evangelization attempts in which the lullian art was present this will allow to shed light on new aspects of the beginnings of the globalization process along with the improvement of our knowledge of the first encounters of latin christendom with other civilizations in other words europes first steps towards a pancontinental vision of the world
digital laser production digital twins of laser processing for multicapability manufacturing of complex components and certification

making europe the first digitally led circular climateneutral and sustainable economy needs major changes across manufacturing efficiencies in energy and material consumption new solutions to problems in certification and standardisation and upskilling of the european workforce dilapro contributes to all of these driving decarbonisation and the twin green and digital transitions via two groundbreaking software tools for laserbased production of complex products dilafact digital laser factory is a sustainable and scalable platform for laser process planning via digital twins of lasermaterial interactions including additive subtractive and thermal processes dilacert digital laser certification tackles a major hurdle in rapidlydeveloping laser and additive manufacturing technologies certification and standardisation in the short dilacert enables end users to easily process production data for certification in the long term it paves the way for remote semiautomated digital certification of produced parts a major paradigm shift in complex part production dilapro grounds its development in specific materials 316l in718 in625 and laser technologies pbflb dedlb and laser texturing as deployed on 6 operational production lines owned by project partners these will be developed as distinct modules during the first half of the project and synthesised into dilafact and dilacert in the projects second half to ensure the competitiveness and sustainability of european manufacturing in the long term other developers and endusers will be able to contribute modules to both software kickstarted by dilapros living communities and innovative ip plan covering both commercial and oa licenses dilapro offers two scalable sustainabilityfocused solutions for the european laserbased highprecision manufacturing industry and will thus not simply develop a single oneoff product but a resilient forcemultiplier for the long term
driving climate positive futures

rmit eu spearheads the driving climate positive futures dreamplan a truly interdisciplinary international and intersectoral phd program uniting european and australian research via 32 doctoral positions for double degree dreamplan brings together a community of visionary changemakers leaders who dream big and develop tangible pathways for solving local and global climaterelated challenges all united by a mission to create a positive impact towards a more sustainable fair inclusive and thriving planet for future generationsthe need for 1 resilience ability to withstand and recover from disruptions 2 restoration ability to repair or rehabilitate degraded ecosystems and 3 regeneration fostering the renewal revitalization and replenishment of ecosystems communities research is more acute than ever the overarching objectives of dreamplan research training program is to create and deliver legacyworthy novel cuttingedge 3icentric training through bestpractice multifaceted multimodal group and individual training options for dcs ultimately breeding the next generation of highperforming esrs equipped with a unique set of skills and capabilities to fully comprehend and address the multifaceted nature and scale of climate change across sectorsdreamplans training program is aligned to contribute to eu missions the european green deal and supporting ris3 strategies and includes 3 annual doctoral schools adopting a novel scaffolding approachdreamplan will fully embrace diversity and through its ecosystem approach develop pathways for esrs towards new mindsets behaviours technologies policies supporting the transition to more sustainable fairer and productive futures
novel nano thin film oxygen electrodes for solid oxide cells

the eu goal of cutting greenhouse gas to zero net emissions by 2050 will put particular pressure on energy conversion and storage systems reversible solid oxide cells rsocs capable of efficiently operating in two modes as solid oxide fuel cell and as solid oxide electrolyser cell are of particular interest to operate the cells with high efficiency and long duration scrutiny of potential oxygen electrode materials and development of novel materials for intermediate temperature itsocs is essential however a methodology to screen the oxygen surface exchange and bulk diffusion kinetics with a ubiquitous easily accessible and reliable technique is still in high demand the fellowship aims to address these urgent demands towards a green economy two chemical vapour deposition methods metalorganic chemical vapour deposition mocvd and atomic layer deposition ald will be wisely combined for obtaining thin film preparation with improved nanomorphology prdoped la2nio4 thin films lpno with surface modification will be prepared to improve the electrochemical properties while maintaining good ionic conductivity the development of the unique in situ isotopic exchange raman spectroscopy iers technique and apparatus will be the second core task of this project this novel raman technique will be used as an alternative and complementary technique to the conventional approach proving more efficient accessible and nondestructive in situ measurements for the candidate as part of her continuing interest in electroceramics the project will link perfectly with her previous experience and will provide her with the opportunity of applying her in depth knowledge to develop novel new skills in the area of solid state ionics especially for nanoscale thin films on the long term she will be able to extend and broaden her existing academic and industrial network and advance her career prospects
a breakthrough active immunotherapy for the treatment of osteoarthritis

osteoarthritis is a debilitating disease affecting the joint and a leading cause of disability worldwide it affects at least 250m people and incurs healthcare costs of toward 05 of the gdp peptinov is developing an active immunotherapy that can halt inflammationdriven destruction of the cartilage in the joints we use a unique approach to neutralise a key proinflammatory protein il6 driving chronic inflammation our vaccinelike approach stimulates the patients own immune system to produce antibodies against excess il6 and neutralise its biological function by doing so we will halt disease progression our treatment will cost 510 of conventional immunotherapies as we inject patients with inexpensive immunogenic peptides to stimulate production of endogenous antibodies phase i clinical trial yielded very encouraging preliminary safety and tolerability data on 24 patients this project will implement the phase ii clinical trial and make our therapy outlicensing ready
sustainable energy systems for refugee and host communities in africa

gathering 18 partners from 3 african 5 european countries and 2 associated countries sunny is a 48months project that aims to provide highly replicgathering 17 partners from 3 african 5 european countries and 2 associated countries sunny is a 48months project that aims to provide highly replicable solutions for green energy transition and energy access in africa to reach that goal five renewable energy technologies reaching trl 78 will be improved adapted to the local context and demonstrated in two sites in uganda and rwanda reaching around 1300 refugees and persons in the local host populationsthe technologies developed in sunny will be upgraded following circular economy and local value chain approaches in order to create economic activity locally as well as ensure relevance of the solutions and longterm sustainability to ensure uptake a strong focus will also be made on costeffectiveness and adapted business models solar home systems will ensure the access to basic energy needs at a household level pr1 clean hydrogen pr2 and biogas pr3 cooking solutions will allow cooking to be decarbonised while improving health conditions refrigerated food storage pr4 and smart solar irrigation combined with biogas will allow to improve food security in rural african areas and address the wef nexus holistic models pr5 and assessment methods pr8 will allow to identify and validate the benefits and sustainability of the technologies while social innovation through among others capacity building will support the longterm socioeconomic impact pr6 and ensure local uptake as well as a strong replicability potential indeed sunny ambitions to widely impact humanitarian energy practices through a replication plan comprising the involvement of 15 replication cases with new interoperability of technologies training activities towards african and euwide energyaccess and development agencies and camps managers and policy recommendations pr8
early detection and screening of hematological malignancies

project sanguine addresses the objectives raised by the cancer mission call which emerged from the growing societal challenge faced by european citizens according to the european cancer information system ecis each year 27 million people in the eu are diagnosed with cancer the sanguine project focuses on hematological malignancies which account for 10 of those cases and aims to target the four objectives of the cancer mission 1 understanding 2 prevention including screening and early detection 3 diagnosis and 4 quality of life improvement of the patients and their relatives the project introduces a novel minimallyinvasive blood test that detects and classifies a set of hematological malignancies the test is based on detecting a combination of epigenetic biomarkers in dna from peripheral blood cells and in cellfree dna the sanguine test will provide superior sensitivity at lowcost which is ideal for screening purposes this is enabled by direct fluorescent labeling of epigenetic marks in patient dna and its analysis on a custom designed microarray the hemachip sanguine team consists of a comprehensive and strong team of expert that will address medical technological and social aspects of the developed diagnostic test expertise from the medical field includes clinical research technology development and access to patients this will enable optimization of the test for hematological malignancies following a usercentric approach and experiencing its implementation in reallife clinical settings the social part of the team includes researchers and patient organization that will promote accessibility of the test to patients and individuals atrisk for screening early detection and disease management in combination with a study aiming to increase the screening rates ultimately our project will provide validated reagents hemachips and data analysis software ready for large scale screening and early stage commercialization