Dragon09/odtu_chatbot huggingface dataset:
neural circuits for error correction

to survive in natural habitats animals move through space according to their goals however the uncertainties of the environment alongside inevitable variations in neuromuscular signals change the context in which a walking step occurs leading to unintended movement thus task performance can be jeopardized if the erroneous action is not rapidly corrected based on current posture and behavioral goals how these aspects of control functions are implemented and coordinated across the central nervous system remains unknown here we propose studying the circuits involved in monitoring our movements since they are key intermediaries between motor planning and posturedependent execution using the compact brain of the fly drosophila melanogaster we will ask two fundamental questions how is neural activity distributed across multiple networks integrated to estimate selfmotion how is this internal estimate used to correct erroneous movement using a selfpaced behavior in which a fly drifting from a stable heading turns based on an internal drift estimate we have found a circuit sensitive to angular velocity richly interconnected to the flys analogue of the spinal cord and higherorder brain areas and critical to driftbased turns we will leverage these results and combine them with electron microscopy behavior physiology optogenetics and modelling to study circuit mechanisms for course correction we will 1 use connectomics and manipulations of neural activity to identify pathways involved in corrective turns 2 record from the identified neurons and correlate their activity with behavior 3 perturb cell typespecific neurons to test their role on selfmotion computations and on corrective turns and 4 test neural activity in different behavioral contexts these experiments will establish unprecedented causal relationships between neural computations and movement and reveal the functional organization of distributed circuits for walking control
biosensor activated biomanufacturing scaleup

industrial biotechnology is one of the key enabling technologies kets identified by europe harnessing the power of microbes for biomanufacturing is one of the most promising approaches to providing a sustainable alternative to a fossil fuel and animal farmingbased economy however fermentation scaleup remains a massive challenge to the commercialization of bioprocesses ultimately hindering the sector from reaching its potential enduro has developed a gamechanging synthetic biology plugin enduro sense to bridge the scaleup gap and enable cheaper and scalable continuous microbial biomanufacturing after successful developments we are ready to perform large scale demonstrations with commercial strains from industrial partners achieving a key milestone that will unlock further investments to finance the commercial deployment of the technologythis eic grant is crucial to position our company in a market that is rapidly evolving
shortwave infrared photodetectors based on lowcost environmentally friendly insb colloidal quantum dots

the development of lowcost optoelectronic devices in the shortwave infrared swir 12 um would open up a huge number of applications such as 3d and adverse weather imaging night vision for surveillance and automotive safety chemical hazard detection environmental sensing and biomedical diagnostics etc leading to a direct and huge impact on quality of life health and security provided that such technologies are available at low cost and high volumes to serve consumer electronics markets to address this large consumer market volume the necessity for lowcost nontoxic and complementary metal oxide semiconductor cmos compatible swir photodetectors is therefore indispensable to date the swir has been served by costly epitaxial iiiv semiconductors which are not monolithically integrated to silicon cmos electronics and suffer from high growth cost and low volume manufacturing compared to epitaxial technology solutionprocessed technology based on colloidal quantum dots cqds is more promising for swir photodetectors due to low cost and high volume manufacturing and their cmos integrability on the other hand insb is an environmentally friendly iiiv semiconductor which possesses a narrow direct band gap and the highest room temperature carrier mobility and the smallest exciton binding energy of all semiconductors thus being ideal for swir photodetectors therefore ecoswir aims to develop a whole new material platform based on nonepitaxial insb cqds that in contrast to current iiiv technologies will enable cmos compatibility and largescale production of optoelectronic materialsutilizing this achievement ecoswir will provide a proof of principle of insb cqds swir photodetectors with performance that cannot be met by any prior cqds devices that will be competitive to the costly epitaxial technology and warrant introduction into highvolume consumer electronics markets and pave the way towards printable swir photodetctors
amber worlds a geological anthropology for the anthropocene

the anthropocene compels us to question established categories and binaries through which we understand the world and act in it human and nonhuman life and nonlife biological and geological what we still lack is a theoretical framework methodological and storytelling tools to analyse environmental and social concerns alongside geological pasts and futures amber addresses this key challenge by drawing scientific understanding of ecological and geological relations into a global ethnography of the extraction and exchange of a unique emblematic gemstone amber is a fossilised resin secreted by plants between 16 and 300 million years ago it is found across the planet and is one of the earliest recorded items in longdistance trade aside from its ornamental value amber contains prehistoric organic material leaves invertebrates dinosaur fragments this has generated intense scientific interest so amber is now studied in palaeontology and geology laboratories to answer fundamental questions about the planets biological evolution and previous phases of mass extinction this project will be the first indepth global study of amber across industry trade and science amber breaks new ground by bringing together three dimensions in a common analysis anthropological frameworks of global circulations the political ecology of resource extraction and nonhumanist approaches to scientific research and ethics of care beyond the human rooted in anthropology the project considers the multiple and entangled worlds of amber its extractive economies in the wartorn forests of kachin state its scientific study in laboratories in china and europe and its wholesale trade in santo domingo kaliningrad and the baltic states and china the project examines their intersections through collaborative and comparative research and will thus lay the conceptual groundwork for a new geological anthropology for the anthropocene
fleet and traffic management systems for conducting future cooperative mobility

the conductor projects main goal is to design integrate and demonstrate advanced highlevel traffic and fleet management that will allow efficient and globally optimal transport of passengers and goods while ensuring seamless multimodality and interoperability using innovative dynamic balancing and prioritybased management of vehicles automated and conventional conductor will build upon stateoftheart fleet and traffic management solutions in the ccam ecosystem and develop next generation simulation models and tools enabled by machine learning and data fusion enhancing the capabilities of transport authorities and operators allowing them to become conductors of future mobility networks we will upgrade existing technologies to place autonomous vehicles at the centre of future cities allowing heightened safety and flexible responsive centralized control able to conduct traffic and fleets at a high level these innovations will lead to less urban traffic and congestion lowered pollution and a higher quality of life project innovations will be integrated into a common open platform and validated in three use cases testing the interoperability of traffic management systems and integration of different transportation means for both people and goods use case uc1 integrates traffic management with intermodality uc2 tests demandresponse transport and uc3 urban logistics in each use case and its demonstrations simulations will be validated through real life data
land use and management modelling for sustainable governance

as part of the european green deal the eu must achieve climate neutrality by 2050 the land use sector has a key role to play which is recognized in the fit for 55 package where a climate neutrality target for the agriculture forestry and other land use afolu is set for 2035 to enable fundamental transformations in the land use sector necessary to achieve the green deal lamasus proposes a step change in land use sector governance from policy formulation to implementation to monitoring lamasus builds on i decades of experience in direct policy support ii unique modeling tools such as globiom the only model that integrates agricultural and land use sectors and capri magnet and clue which underlie jrcs land use policy assessments and iii novel approaches mobilizing machine learning and citizen science the project is driven by four key elements evidence dynamic monitoring of land use management and related policies for evaluation and model calibration understanding stateoftheart econometric and biophysical models to assess the role of past policies on changes in land use and management and their economic and environmental impacts tools a highlyintegrated policy modeling framework with full sectorial coverage from agriculture and forestry to the whole economy accounting for carbon biodiversity and all relevant sustainability dimensions at multiple scales land use actors country eu level global guidance a multilevel stakeholder dialogue for codesign of agriculture forestry and climate policies by the ec national and local governments and citizens made accessible to stakeholders across multiple spatial scales through the novel webbased lamasus portal in this way lamusus will create a new level of societal engagement in which local actors contribute to the design of effective and efficient eu policies for climate neutrality and will serve as an exemplar for other policy processes within the european green deal
fully digital blockchainbased laboratory operations control system for realtime and auditproof good manufacturing practice conformity

blocs aims at monitoring the analyses performed on the laboratory software and at detecting whether the raw data have been altered by anomalies resulting from protocol errors or actions that do not comply with the gmp rules blocs records in real time the events that occur on the files from the lab software and sends them to a smart contract on a blockchain in order to properly report the status of the analysis the business logic of each software for file creation or invalid action events eg file deletion is recorded immutably in a smartcontract any deviation is reported and triggers real time configurable alarms the strength of this approach lies in the trust provided by the smartcontract running on the blockchain it contains the business logic that decides whether the latest event impacts the validity of a laboratory analysis performed there is no way to bypass this gmprelevant business logic no way to override the blocs and the history of the blockchain
anticancer chaotropic pva micelles with dnamotifmediated targeting

in this project i propose an innovative nanoscale therapeutic system for the optimized delivery of ellipticine elli as a proof of concept to cancer cells utilizing polyvinyl alcohol pvaa biocompatible and biodegradable polymerwe will form micelles that encapsulate elli within their hydrophobic coreto overcome challenges associated with cellular uptake and nanoparticles trafficking we will functionalize the surface of the micelles with boron clusters to endow the nanocarrier with chaotropic activity thereby facilitating enhanced membrane translocation further we will integrate dna motifs specifically pyramidshaped linkages lpy into the boron cluster framework through coordination bonds this modification is anticipated to permit selective targeting of cancer cells thereby maximizing therapeutic efficacy while minimizing collateral damage to healthy tissuesthe therapeutic efficacy of the resulting complex formulated as elliapvanlpyb12br12n2 will be comprehensively evaluated using both in vitro 3d cell culture models and in vivo mimicking approaches including 3d bioprintingoverall this project will allow me to carry out a 2year project independently growing towards a mature professional and independent researcher in the drug delivery field reinforcing my expertise on advanced characterization of nanoparticlecell interactions
superlattices of perovskite quantumdots for the digitalage

photonic integrated chips are key for the eus pursuit of faster and more efficient computers aiming to support the digital revolution while reducing the costs of ict however progress in photonic devices is held back by challenges in the miniaturization of onchip light sources superqd aims to tackle these challenges by using superlattices of lead halide perovskite quantum dots as micronsize onchip emitters thanks to their colortunable and bright fluorescence these nanocrystals solids are efficient micronsize light downconverters that will allow implementing more color channels per device without compromising miniaturization moreover the coupling between quantum dots results in superior exciton mobility and emission from collective quantum states superfluorescence which are promising for future applications in transceivers and quantum computers superqd comprises four tasks 1 quantum dots prepared via wet chemistry are assembled into superlattices with tunable structure 2 innovative diffraction techniques are employed to characterize superlattices with a focus on structural and energetic disorder 3 collective optical properties are studied via space and timeresolved spectroscopies to discover new structurecoupling relations with the goal of tuning the superlattices quantum light emission through their structure 4 finally superlattices with optimized properties will be installed in integrated photonic chips to demonstrate onchip downconverting optical amplification upon photoexcitation from an integrated blue laser these proofofconcept devices will create new connections between colloidal nanomaterials and photonic integrated chips leading to groundbreaking advancements in both fields superqd will be hosted by lund university and the massachusetts institute of technology leveraging the fellows and host institutions expertise to ensure a mutual benefit from the action and the success of the ambitious goals of the project
health cognition family and employment among men

men are more likely than women to die prematurely and a great deal of mens excess mortality is preventable improving mens health and cognition is not only critical for achieving gender equality but also for enhancing and extending mens potential to contribute to their families the labour market and society as populations grow older homme studies how mens changing family and working lives influence their health and cognition mens family and working lives are changing men now lag behind women with regards to tertiary education female labour participation has increased while male labour participation has slightly decreased men are more apt to lose their job due to technological change male childlessness has risen dramatically much more than female childlessness in many western countries one out of four or almost one out of three men are now childless at age 40 fathers are participating more in childcare and men have partially lost their role as family breadwinners so far insufficient research has examined the consequences of these changes on mens health and cognition homme capitalizes on the richness of norwegian population register survey and genetic data to examine how mens rapidly changing family and working lives are related to their health and cognition across adulthood as well as across cohorts periods and between communities we focus on young adulthood and midlife the life period most characterized by family transitions and work experiences we examine cohort and period differences mens workface interface the male breadwinner model and fathers participation in childcare and disentangle selection and causality our data covers genes parents former spouses and partners selfreported clinical and register measures of health register data on work participation and occupation and cognitive trajectories of n12000 men between the late teens to ages 36 to 69 and potentially beyond pending funding of the project
improving research and innovation to achieve a massive integration of solar renewables

the project twinsolar aims at strengthening the research and innovation capacities of the public laboratory piment of the university of la reunion ur which is located in one of outermost regions of europe twinsolar will create new opportunities inside and outside of europe and more specifically in the zone surrounding reunion island and in insular territories that face similar challenges this capacity building will be done through the establishment of effective partnerships with the technical university of denmark dtu and the fraunhofer institute for solar energy systems fraunhofer which are internationally renowned research organizations the dissemination and outreach of twinsolar will be achieved with the support of the conference of peripheral maritime regions cpmr and the regional ri agency of reunion island nexa particular emphasis will be placed on issues related to the massive integration of solar energy production in insular territories
sustainable pigments and glitter from renewable cellulose

inspired by nature we developed effect pigments prepared from a single organic and renewable component extracted from plants cellulose nanocrystals obtained via selfassembly these pigments offer one of the most sustainable alternatives to all existing products including microplastic partially biodegradable glitter and unsustainably sourced mica and titaniabased pigments securing this erc2022poc2 proposal will allow us to bring this muchneeded technology from trl6 to trl7 by addressing 4 challenges 1 finding a supplier of cellulose with tonscale production capacity 2 finding the bestsuited manufacturing equipment with innovative options that we did not explore in our previous work 3 delivering kilograms of our materials to endusers who are in need of this technology for them to validate the technology 4 quantifying the benefits of our products against existing alternatives using life cycle analysis biodegradability and ecotoxicity studies
highresolution weather observations east of dakar dake

highresolution automatic weather monitoring system east of dakar dake will probe the internal structure and dynamics of tropical mesoscale convective systems mcs and design a novel methodology for flood and storm early warning
the only free science philosophy without presuppositions from classical german philosophy to contemporary philosophy

tones aims to explore the idea of philosophy as a presuppositionfree science and to develop this idea as a new metaphilosophical paradigm that provides a theoretical underpinning for valuefree science and prejudicefree judgment and the idea of philosophy as a presuppositionless science pls has a significant history it is traditionally associated with the philosophy of gwf hegel and is originally developed both to show the uniqueness of philosophy and to ensure the neutralobjective standpoint of philosophy growing number of scholars have noticed the significance of pls mainly to understanding hegels philosophy despite this interest scholars have largely overlooked the prehegelian tradition of pls in classical german philosophy cgp the metaphilosophical significance of pls and its distinct potential to contribute to contemporary theories that seek freedom from presuppositions tones aims to fill this gap the project is motivated by the following key questions 1 what are the origins of pls and how was it developed in cgp 2 what are the metaphilosophical implications of pls for the uniqueness of philosophy compared to other sciences 3 how the unique standpoint of pls can fruitfully contribute to contemporary fields that strive for presuppositionlessness or value neutrality such as implicit bias and valuefree science
the first effective and safe reversal agent to stop or prevent lifethreatening bleeding in patients taking the emerging generation of anticoagulants

50 million patients worldwide use oral anticoagulants to prevent venous thrombosis and stroke since the last decade unpredictable and risky indirect anticoagulant treatments are being replaced by the latest generation of bloodthinning medication factor xa direct oral anticoagulants fxadoacs used by 10 million patients in euus with superior predictability efficacy and safety profiles these lifesaving medications remain associated with a risk of uncontrolled and severe bleeding alarmingly there is no safe reversal agent that restores blood clotting in patients who take fxadoacs resulting in lifethreatening bleeding episodes and 400k hospital admissions to address the urgent unmet need varmx has developed vmxc001 the first effective and safe reversal agent to fxadoacs varmx requests a 25m in grant and 15m in equity eic to accelerate upscaling and improve the costeffectiveness of the complex manufacturing process required to produce vmxc001
autopoietic cognitive edgecloud services

the increasing need for cloud services at the edge edgeservices is caused by the rapidly growing quantity and capabilities of connected and interacting edge devices exchanging vast amounts of data this poses different challenges to cloud computing architectures at the edge such as i ability to provide endtoend transaction resiliency of applications broken down in distributions of microservices ii creating reliability and stability of automation in cloud management under increasing complexity iii secure and timely handling of the increasing and latency sensitive flow eastwest of sensitive data and applications ivneed for explainable ai and transparency of the increasing automation in edgeservices platform by operators software developers and endusers aces will solve these challenges by infused autopoiesis and cognition on different levels of cloud management to empower with ai different functionalities such as workload placement service and resource management data and policy management aces key outcomes will be i autopoiesis cognitive cloudedge framework ii awareness tools aiml agents for workload placement service and resource management data and policy management telemetry and monitoring iii agents safeguarding stability in situations of extreme load and complexity iv swarm technologybased methodology and implementation for orchestration of resources in the edge v edgewide workload placement and optimization service vi an app store for classification storage sharing and rating of ai models used in acesaces will be demonstrated and validated in 3 scenarios demanding for support of highly decentralised computing ability to take autonomic decisions reducing costs of cloudedge management and increasing their efficiency thus reducing impact on environmentto foster the uptake of aces outcomes beyond its lifespan different activities are foreseen to drive adoption to a wider network of stakeholders in key sectors