Dragon09/odtu_chatbot huggingface dataset:
accelerate the design and insertion of noncrm hard materials for next generation extreme applications aimnext

the aimnext project arises from the common need of european academy and industry to educate and train the next generation of experts in the field of sustainable design of material solutions for engineering applications in this regard the need to accelerate the design and insertion of hard material tools and components manufactured using noncritical raw materials for next generation extreme applications has been identified as an area of strategic economic and environmental importance for the european union where accordingly the skills developed by the doctoral students are adapted to the current and future industrial needs and the ongoing transformation towards more sustainable production processes to address this need a coherent international interdisciplinary and intersectoral training and research programme has been developed involving a selection of some of the best european universities in the field together with worldwide leading industrial organisations covering fundamental elements of the product value chain in key industrial sectors ie mining manufacturing and construction engineering by participating in the aimnext project the 10 doctoral candidates will receive i top level interdisciplinary training through a defined scheme where each fellow is exposed to all three technical environments ii intersectorial training articulated through a wide variety of strategic research themes and the different application areas represented in the consortium and iii international training through a portfolio of mandatory networkwide training events and secondments at academic and industrial partners thus the combination of technical and transferrable skills acquired by the fellows through technical training interdisciplinary research and industrial exposure will enhance their employability and open up solid career opportunities to them particularly within a field where skilled phd engineers are currently an extremely scarce resource
clinical validation of a novel nonopioid analgesic derived from the portuguese sea for treating chronic pain

sea4us is a worldclass biotechnology company with a focus on translating marinederived compounds with therapeutic potential for unmet medical needs into pharmaceutical assets sea4us has developed a platform focused on drug discovery and development of novel pharmaceuticals based on its core expertise in ion channels and marine biology sea4us is particularly focussed on developing and commercialising therapies for chronic painsea4us has developed a groundbreaking therapeutic drug to treat chronic pain in patients chronic pain affects 100 million people across europe 16bn globally and has a devastating impact on quality of life pain is the most common reason people visit their doctors and a leading cause of disability it is a source of enormous social and economic burden costing europe alone over 500 billion euros a year there are many medications on the market for treating chronic pain but they are either ineffective for most types of chronic pain andor have adverse sideeffects opioid drugs are the most effective treatment but also inflict drug addiction habituation and other noxious sideeffects our novel analgesic molecule sea4pain has a novel mechanism of action meaning it is highly effective at treating chronic pain and without any known side effects unlike current drugs on the market sea4pain is a firstinclass drug and has the potential to ease the suffering of billions of people globallythis eic accelerator project called sea4market will enable us to clinically validate our novel analgesic through completion of firstinhuman trials and outlicense our technology to make a rapid entry into the multibillion euro chronic pain market eic support is essential to deliver this highrisk high reward project and will enable the sustainable growth of our business we will reinvest revenues from our licencing deal back into our project pipeline to solve other unmet medical needs and ensure the sustainable growth of our company
capacitation of quantumentangled nvcenter sensing

cquens is an innovative research project aimed at advancing the field of quantum sensing by developing the next generation of nvcentrebased quantum sensors with quantum entanglementenhanced performances to achieve this goal cquens brings together six worldleading experts from four european countries who have made pioneering contributions to this research field that are essential for the realisation of the cquens research visionthe project will focus on developing novel sensing protocols based on engineered correlated quantum spin states such as entangled states and dynamical phase transitions these protocols will outperform current quantum sensing scenarios based on independent spins in terms of sensitivity and precision the development of these protocols will build on strong theoretical support with the development of quantum control methods advanced signal processing protocols and experiment modelling optimisation and analysiscquens will conduct laboratory demonstrations of these protocols using multiqubit quantum registers undergoing magnetic dipolar interaction to create multiqubit entanglement and manybody dynamics in addition the project aims to bridge the knowledge and technical gaps to implement laboratory prototypes of nvbased quantum devices that can find application in a wide range of fields as diverse as semiconductor testing or medicine these objectives will leverage pivotal advances in diamond quantumcapable materials including nv growth control and surface treatmentsthe outcomes of cquens will be disseminated to the scientific community industry and society to promote the adoption of these technologies and maximize their impact in basic science material manufacturing microelectronics healthcare and metrology the project will also contribute to training quantumliterate physicists and engineers and to consolidate the european supply chain on diamond quantum sensors crucial to maintain europes competitiveness
glycoprotein nglycosylation from nonlife to eukaryotes a doctoral network to expand the knowledge on a ubiquitous posttranslational modification of proteins

the glycon training network aims at training doctoral candidates dcs to acquire the skills to develop different innovative strategies to 1 understand the diversity and structural complexity of archaeal microalgal and viral nglycosylation and 2 harness this knowledge for new solutions in biomedicine and biotechnologyprotein nglycosylation or the attachment of oligo and polysaccharides at specific asparagine residues is conserved throughout life and is now observed even in the viral world in contrast to eukaryotes whose wellstudied nglycosylation machineries are relatively simple archaea microalgae and bacteria utilize a wide variety of monosaccharides to create a wealth of structurally diverse nglycans and the same holds true for some recently discovered viruses because protein glycosylation occurs far downstream of protein synthesis the complexity and diversity in nglycan structures are poorly understood in detail this holds true specifically for nglycosylation events that are the subject of the glycon program those in archaea microalgae and viruses understanding of the how and why of nglycosylation in archaea microalgae and viruses will open up many possibilities ranging from drug discovery antivirals to biotechnology glycoprotein and glycoprocessing enzyme engineering for materials and life sciences the glycon network brings together a diverse group of glycobiology researchers with worldleading expertise in microbiology bioorganic chemistry computational and structural biology bioinformatics and chemical biology the glycon dcs will have their own individual project with one glycon expert and will through research internships be exposed to complementary glycoscience all individual phd projects while rooted in fundamental science have a practical application either in biotechnology or in biomedicine as will be explored through secondments with our associated partners
sunerc sunergy community and ecosystem for accelerating the development of solar fuels and chemicals

sunerc csa overarching objective is to aggregate fragmented knowledge and develop the framework conditions to overcome scientific technological organizational and socioeconomic challenges to accelerate innovation and enable the transition of technologies for solar fuels and chemicals from laboratory and demonstrator level to largescale industrial and broad societal application through a holistic approach sunerc will contribute to circular economy by replacing fossilderived fuels and chemicals by renewables and carbon recycling as key element towards the eu netzero emissions target by 2050 sunerc will build upon the work of sunergy a paneuropean initiative on fossilfree fuels and chemicals from renewable power and solar energy with to date over 300 supporting organisations across and beyond europe sunerc specific outcomes during the csa will be to develop an inclusive paneuropean innovation community and ecosystem on solar fuels and chemicals with global outreach linked to political and societal needs gathering stakeholders from different fields sectors and disciplines around a shared vision and coordinating with existing initiatives to ensure complementarity develop a roadmap and a blueprint to implement it as main drivers to identify and tackle longterm research and innovation challenges to defossilize society with solar fuels and chemicals prepare the foundations for a largescale research and innovation initiative lsri ready to be launched at the end of the csa through an instrument to be agreed upon with the european commission and the member states the lsri will continue developing the ecosystem and supporting the implementation of the roadmap speeding up industrial and societal uptake of technologies for solar fuels and chemicals in the eu and contributing to wider longerterm impacts including those on increased autonomy in key strategic value chains for resilient industry outlined in the horizon europe work programme
regenerated cotton for electronic textiles

the main objective of the retex msca se project is to form a world class international and intersectoral network of organizations working on a joint research programme in the field of novel sustainable electronic textile materials by replacing conventional textile materials with sustainable environmentally friendly and advanced materials such as regenerated fibres from cotton fabrics this can only be achieved by bringing together worldclass experts in materials polmers environmentalists chemists software engineers and designers with stateoftheart innovations and processes in their respective fields of expertise the participants will exchange skills and knowledge to create sustainable textile materials strengthening collaborative research between different countries and sectors retex will also refine and produce potential commercial market opportunities for nonacademic participants in the project our goal is to train next generation of researchers and innovators in sustainable textiles through crosssectoral and training modules the staff members will develop new skills be exposed tonew research and innovation environments international networks new industrial processes and techniques whilst widening and enriching career development through crosssectoral knowledge transfer and international mobility
overcoming mechanicallyinduced resistance to chemoimmunotherapy in pancreatic cancer

cancer progression is closely associated with generation of mechanical stresses that cause the compression of tumor vessels drastically reducing delivery of drugs my coworkers and i found that host cells and extracellular matrix in tumors generate these stresses furthermore we identified the antihypertensive losartan to alleviate intratumoral stresses and decompress vessels allowing drugs to enter the tumor my colleagues tested losartan in pancreatic cancer patients and found improved responses to chemoradiation nonetheless losartan cannot alleviate all stresses and my preliminary data indicate that they induce chemotherapy resistance mechanoresistance thus even though vessel decompression facilitates drugs entering the tumor mechanoresistance renders cancer cells insensitive to drugs alleviating mechanoresistance is an urgent clinical need but this mechanism has not been well studied and strategies to overcome it have not been developed successfully to address this challenge i will employ a mixture of cuttingedge bioengineering and biology methods to identify the intracellular mechanisms that promote mechanoresistance using in vitro and mouse models of pancreatic cancer i will then employ inhibitorsdrugs of the identified mechanisms to overcome mechanoresistance in vitro and in vivo to determine if they increase the efficacy of chemotherapy i will also confirm whether these drugs work more effectively with losartan or alone using the best performing regimen i will assess the immunological effects and efficacy in combination with immunotherapy which has yet to induce a benefit in pancreatic cancer trials in parallel in order to take this groundbreaking goal of improving pancreatic cancer therapy to the clinic i will examine the existence of the same mechanoresistance mechanisms in human tumors the project will introduce novel patientspecific therapeutic strategies to directly boost clinical trials in pancreatic cancer patients
molecular and genetic determinants of plant tolerance to viruses

viral diseases cause severe damage to cultivated plants resulting in global crop losses in the wild however plants are typically free of viral disease symptoms despite recurrent infection naturally tolerant plants have a significant viral load but their growth development and reproduction are only minimally affected the aim of the tolgreen project is to identify viral and host determinants of tolerance by using arabidopsisinfecting rna viruses such as tobacco mosaic virus tmv and the related oilseed rape mosaic virus ormv as models certain natural accessions of a thaliana col0 are tolerant to tmv whereas other ecotypes sha show disease by contrast col0 plants infected with ormv are initially symptomatic but develop tolerance in the new leaves the host laboratory demonstrated that this latter tolerance phenotype depends on genes required for the production of primary and secondary sirnas and also correlates with the loss of the activity of the viral rna silencing suppressor vsr the tobamoviral vsr proteins inhibit antiviral rna silencing by sequestration of small interfering rnas sirnas which inhibits the assembly of the antiviral rnainduced silencing complex risc therefore tolerance may occur when the vsr sirna binding activity is saturated by host or virusderived sirnas using the latest tools of molecular genetics and proteomics tolgreen will determine arabidopsis genes viral and hostderived sirnas as well as vsrinteracting proteins that control vsr activity and are involved in tolerance understanding the molecular mechanism of tolerance will provide important tools for the breeding of resilient virustolerant crops for a more sustainable agriculture
universal interoperative sustainable agriwater management platform

water quality and quantity are under arising pressure from agricultural activities that may cause overexploitation of natural waters and pollutants runoffs eg nutrients pesticides these stresses are also compounded by climate change effects to address the complex challenges of agriwater management the universwater consortium will adopt a system of systems approach by developing and improving technologies designed to optimise water resources uses in a fully integrated way a dedicated interdisciplinary and intersectoral consortium of 15 partners from six european countries will a develop innovative portable and insitu sensors for a number of parameters and pollutants salinity nutrients cec microbiological indicators and b couple them with earth observation imaging and advanced explainable and robust artificial intelligence techniques as well as c develop costeffective sustainable methods based on naturebased and technologybased solutions for water remediation at the point of need and d promote the adoption of the developed methods through pricing incentive provision these technologies will be integrated into decision support systems dsss that will be tested at three case studies tackling onfarm treatment of dairy soiled water mitigation of soil salination through water reuse and optimisation of fertiliserpesticide application for freshwater preservation going beyond universwater will upscale these local dsss into a common platform where a suite of dss tools can be adapted to different situations after being tailored to the local factors thereby developing a modular extensible and holistic universal dss
ultrafast floquet polaritonics metasurfaces

electromagnetic waves interacting with materials give rise to polaritons hybrid excitations of light and matter among these hyperbolic phonon polaritons hphps in polar crystals stand out for their low loss and anisotropic behavior concurrently floquet theory has gained prominence in nanophotonics enabling the engineering of topological properties in periodically driven systems the utopia project aims to merge these domains establishing ultrafast floquet polaritonics as a cuttingedge field it seeks to demonstrate this concept in natural van der waals materials and synthetic metasurfaces polariton research has evolved from plasmon polaritons to encompass phonons excitons and cooper pairs phonon polaritons with their anisotropic response have opened avenues for nanophotonics recent discoveries in twodimensional van der waals materials like hexagonal boron nitride have unveiled hyperbolic polaritons in natural crystals utopia bridges phonon polaritons and floquet theory aiming to pioneer tailored lightmatter interactions floquet systems endow physical systems with synthetic dimensions via periodic potentials enabling nonreciprocal systems topological phases and 4 dimensional physics while floquet quasienergy states have been demonstrated in graphene the field of floquet polaritonics remains underexplored lacking a demonstration of temporally driven changes in phonon polariton dispersionutopias objectives include 1 demonstrating floquetdriven topological polaritonic transitions via grating coupling in natural materials mapping nearfield observables to the farfield and enabling dynamical phase transitions 2 designing metasurfaces supporting synthetic hyperbolic polaritons expanding floquet polaritonics to optical frequencies and various temporal modulations3 achieving infrared light amplification via polaritonassisted anisotropic parametric amplification harnessing polaritonic excitations for efficient amplification
charting cell typespecific nucleic acid immunity

metabolic and immune pathways form an intricate network that maintains homeostasis we recently unveiled that the stimulator of interferon genes sting central to triggering cytosolic dsdnadependent type i interferon ifn responses inhibits the desaturation of essential dietary polyunsaturated fatty acids pufas sting thereby controls the generation of longchain pufas lcpufas that in turn inhibit sting activation this double negative regulatory feedback loop operates as a key rheostat of homeostasisinterestingly we found that metabolic tissues such adipose tissues express low levels of sting and that in vitro adipocyte differentiation leads to sting downregulation although they retain their ability to produce type i ifns in respond to nucleic acid challenge this suggests that alleviating the stingdependent inhibition of pufa metabolism may result from or be required for adipocyte differentiation or functionality further this also suggests that adipocytes may possess specific stingindependent cytosolic nucleic acid detection pathways thus nucleic acid detection pathways and pufa metabolism should be interrogated concertedly at the cellular levels within metabolic tissues to uncover how they define tissuespecific immune responses and regulate tissue homeostasis in particular in pathologies presenting with chronic sting activationwithin sentinel we will combine stateofthe art biochemistry and molecular biology approaches and cuttingedge omics tools in vitro and in vivo to identify nucleic acid detection machineries and question the role of sting downregulation in metabolic cells finally we will explore the impact of stingdependent metabolic alterations in pathologies presenting with chronic sting activation sentinel will thus chart an unexplored area of nucleic acid immunity metabolic cell immunity and reveal its impact on homeostasis and pathologies
crimeancongo haemorrhagic fever vaccine and immunotherapy

the cchfvacim project is an ambitious collaborative effort aimed at developing both prophylactic and therapeutic effective countermeasures against crimean congo haemorrhagic fever virus cchfv one of the most threatening vectorborne pathogens widely distributed including in the european continent deep structural biology studies on viral glycoproteins and investigation of the immunogenicity of the viral antigens will be combined with optimisation of an mrna vaccine candidate against the virus and characterisation of the resulting protective immunity as well as with the development of immunotherapeutic monoclonal antibodies mabs based on cchfvs antigenic targetsto achieve the overarching goals the cchfvacim project will build on the success of previous projects such as cchfever fp7 cchfvaccine h2020 and go the extra mile by initiating a unique onehealth platform strategy to address different aspects of this severe public health threat on one hand the project will use several advanced animal models mice sheep and nonhuman primate to assess and compare the efficacy of mrna vaccine candidates mabs and therapeutic mrna on the other hand it will establish a biobank from cchf patients to build up a pipeline for the production of mabs against cchfv from their b cellsimportantly the project will also contribute to capacity building of european infrastructures with the establishment of a platform on mrnabased vaccine at one of the partner institutions ultimately cchfvacim will permit to develop a road map to bring the most efficacious vaccine candidates and immunotherapy tools to clinical trial phase i in humans the project results will be widely disseminated among the scientific community public health authorities nongovernmental organisations outbreak management teams and hospitals with the final scope of both contributing to contain the burden of cchf disease and increasing preparedness to new outbreaks