Dragon09/odtu_chatbot huggingface dataset:
the embodiment of racialization running muslim women and the sense of nonbelonging

muslims are the focus of political anxieties in europe and the us over the last decade numerous studies have documented the racialization of muslims and the impact of those discourses on those identified as such yet the embodied and sensorial dimension of the racialization of muslims remains largely undertheorized embrace posits that to better understand and by extension tackle the effects of racial discrimination in everyday life we need not only to attend to statistics of reported racism or narrated accounts of racism but also to the sensorial and bodily experience of it this project takes recreational running as a fruitful angle to consider the embodiment of race the leisurely activity of running enables an investigation of the effects of racialization on the relation to ones own body environment and to other people the research design utilizes a multimodal ethnographic approach to reveal the embodiment of social hierarchies in social interactions among muslim recreational athletes this project has two main objectives 1 conceptualize how dispositions of nonbelonging shape outdoor activities such as running and vice versa by analysing movement and narratives of movement conceptualempirical goal and 2 to examine and theorize the processes through which the multisensory dimensions of racialization become embodied theoretical goal by proposing a knowledge transfer between the researcher leiden university the netherlands and university of california berkeley usa this project aims to contribute to the theorization of embodied senses of nonbelonging
purine sensors as novel pointofcare devices for seizures and epilepsy

epilepsy is the most common chronic brain disease affecting 70 million people worldwide accurately diagnosing epilepsy remains a major clinical challenge due to the lack of noninvasive molecular diagnostic tools purinergic signalling via extracellularly released adenosine triphosphate atp and its downstream purine derivatives is increasingly recognised to contribute to increased hyperexcitability states in the brain and thus seizures hence these can be potentially identified as novel promising therapeutic targets for the treatment of epilepsy but also as a source of diseasespecific biomarkers however the diagnostic potential of purinergic signalling for epilepsy remains unclear and current methods of detection are either unsuitable for pointofcare application or lack disease specificity employing a multidisciplinary approach including sensor development testing in preclinical models of epilepsy and testing in patients we will develop a new userfriendly pointofcare sensor which allows the measurement of specific purines and evaluate the diagnostic potential of blood purine expression changes combining my research experience in the development of biosensors with the expertise of my primary dr tobias engel rcsi and secondment prof nicholas dale university of warwick prof norman delanty beaumont hospital prof felix rosenow frankfurt university supervisors on purinergic signalling and the development diagnostic devices atpsensor will increase our understanding of purinergic signalling and provide new tools to support the diagnosis of epilepsy the skills acquired during the research project the excellent training record of the supervisors and host institutions and the outstanding resources for learning and development available at rcsi and collaborator institutions will give me the tools necessary to become a highly employable neuroscientist
risks resources and inequalities increasing resilience in european families

the problem that reusilience tackles is of lack of adaptive capacities or resilience in some families the context is of fastpaced changes in labour markets to which families are key responsive mechanisms cushioning potentially negative impacts and enablingdisabling risktaking but some families cannot respond the project answers 2 research questions what challenges and difficulties are created or exacerbated for families by labour markets in the new world of work and how do families try to overcome them how do policies contribute to family resilience especially in terms of their inclusiveness flexibility and complementarity to answer these questions reusilience looks at what different families actually do in situations calling for adaptiveness eg need to change labour supply need to engage in training and places this in a social and policy context through both paneuropean analyses of existing data and new focus group research in 6 different countries be es hr pl se uk the project will identify the level of risk and socioeconomic insecurity faced by families across europe their relative capacity to absorb socioeconomic shocks and the role of policy the project is organised in 2 pillars a stocktaking pillar and a policy lab the pillars are designed to closely interlink in terms of evidence flow and mission to share some methodologies and to have inbuilt pathways to impact the lab involves citizens and experts directly in policy review and problem solution and also uses simulations and other methods to roadtest policy solutions among the outputs are a compendium of the risk situation of europes families a series of dynamic analyses of actual risk behaviour accounts from families about how they view risktaking and tradeoffs between work and care critical reviews of policies a questionnaire on family resilience taken to proof of concept stage a set of policy proposals and roadmaps for their implementation
batterbattery passport for resilient supply chain and implementation of circular economyy passport for resilient supply chain and implementation of circular economy

the battery although central to the green transition of road transport currently suffers from a supply chain that lacks traceability sustainability resiliency and circularity critical raw materials crms are essential for battery manufacturing the explosive growth of electric vehicles driven by climate neutrality policy objectives will pressure the crm supply chain and increase eu dependency on third countries resulting in decreased competitiveness for eu automotive and battery manufacturers implementing the digital battery passport dbp concept in the battery value chain could resolve these issuesthe main goal of the base project is to develop validate and implement a working dbp service as mandated by the regulation this will be achieved by exploiting data collected through a number of constantly evolving tools and methods ensuring a transparent secure and costefficient platform operation while also catalyzing the growth of circular businesses base will develop transparent methodologies to calculate battery performance and esge indicators ensuring traceability down to the crm level throughout the entire battery value chain in the physical domain this will be achieved through the mass balancing approach on the data management side by exploiting distributed ledger technology base will ensure builtin data authenticity verification along the value chain with no data duplication avoiding data manipulation assuring privacy by design and promoting data interoperabilitythe dbp will provide uptodate and accurate data on battery performance indicators remaining useful life dismantling material composition and safety this will allow for an increase in the useful service life of batteries and more efficient recycling which will enhance resource efficiency reduce waste and decrease eu dependency on crms from third countries the applicability of the dbp will be demonstrated through four pilot use cases
unravelling the history of undersea oceanic plateau volcanism and its environmental impact in earths past

oceanic plateaus are amongst the largest geological phenomena on earth and their undersea volcanic formation had profound environmental effects such as climate warming and ocean anoxia whilst huge progress has been made to link their landbased counterparts continental flood basalt provinces with climate change and mass extinctions oceanic plateaus have been comparatively understudied due to their limited accessibility and relatively benign ecological impact yet plateau volcanism triggered severe climatic and environmental disruption but the precise mechanisms by which they influenced the earths surface are unclear further most known oceanic plateaus formed in the cretaceous with their likely existence and environmental impact earlier in earths history seldom consideredthe seavolc project utilizes my expertise in studying past environmental crises and geochemically fingerprinting largescale volcanism to reconstruct the mechanisms by which oceanic plateaus triggered global change and for the first time investigate the history and impact of older plateaus that no longer exist combining inorganic and organic geochemistry i will create global maps of tracemetal nutrient disruption and biological productivity during times of cretaceous and triassic plateau activity resolving the relative environmental impact of this process vs co2 output and warming is critical to understand whether continental and oceanic volcanism influenced the earth system differently and why the former was often more lethal stateoftheart geochemical proxies that have recorded cretaceous episodes of undersea volcanism will be applied to siluriandevonian sedimentary archives of cretaceouslike anoxic events showing whether earlier environmental crises were also linked to plateau formation for the first time exploring this possibility provides a unique new perspective how the earths interior and its interactions with surface environments have evolved over time
interoperability network for the energy transition

interoperability depends on cooperation of multiple domains while for the energy sector technical interoperability is quite well established interoperability of functions and businesses needs more attention even when standards are defined and interoperability models agreed framework setters product developers and users need to agree on their deployment and make sure that solutions are compatible with definitions the interoperability network for the energy transition project intnet establishes an open crossdomain community bringing together all stakeholders relevant for the european energy sector to jointly work on developing testing and deploying interoperable energy services the community will be formally established to exist beyond project lifetime with a comprehensive fair knowledge platform and a series of attractive events it guides those who deal with the heterogeneous interoperability landscape of energy services to support ongoing harmonization of energy services intnet will institutionalise an assessment methodology and maturity model imm involving legal and regulatory bodies from the beginning and constant exchange of interoperability initiatives and standardization bodies will build a deep consensus on how european governance and industry can foster interoperability at all levels starting from an extraordinary well balanced and connected consortium of researchers framework setters eg ministry and eu wide associations standardisation and communication experts intnets community approach guarantees wide outreach intnet will establish a framework for interoperability testing in ongoing projects and harmonize test procedures in a network of closely cooperating selfsustained testing facilities energy service solutions based on the novel imm and tested according to the intnet certification process will be awarded with a widely known quality seal for interoperable smart grid and energy products working title intnet approved
concept development of a system for pods and podcarriers to be used as moving infrastructures mainly for rail but as well for road and ropeways

two major issues of secondary lines rail transport are need to change the train for many destinations and to be bound to a timetable pods can be used to adopt rail transport better to the users demand by higher flexibility and efficiency as well as realising ondemand rail transport the project pods4rail aims to develop a concept for pods and podcarriers on railway in order show the approach podcarriers are serving as a moving infrastructure and the pods are loaded and locked on them for the transport the main focus in pods4rail is the rail podcarrier which is presented in detail nevertheless podcarrier for road and ropeways are taken into consideration on a conceptual level to ensure the transferability of the concept related use cases and business cases are identified and analysed
from silk to sealant the production of an enhanced biomedical silk glue biopolymer from genetically engineered silkworms

advancements in postsurgical healing are a major topic in biomedical science and require innovations in materials science in many medical procedures current medical glues are more efficient than traditional sutures but they still lack sufficient wettolerant adhesive strength biopolymers are naturally derived and biocompatible and present enormous potential for applications such as tissue glue to address the adhesive challenge we propose gemsilk an innovative and interdisciplinary framework integrating analytical techniques of material science with genetically engineered silk glue our key objective is to develop a caddisflyderived and inherently wettolerant aquatic silk glue recombinant protein expression system in the domestic silkworm bombyx mori utilising crisprcas9 caddisfly aquatic silk glue dna motifs will be inserted into the silkworms silk gene the resulting stable mutant lines will produce commercial quantities of wettolerant silk glue by training through research and a secondment at the lab of supervisor seibs collaborator i will gain essential stateoftheart skills in novel silk biopolymer design and silk analysis moreover the silk glue product will undergo intellectual property evaluations with seib further augmenting my professional skill set with this essential process and the potentials beyond gemsilk will also be assessedduring gemsilk i will gain substantial and rigorous training in silk analysis and essential assays for silks based healthcare i will be located at fraunhoferimes new worldclass multidisciplinary applied insect biotechnology research institute over the past months seib and i have honed gemsilk combining seibs profound experience in silk analysis for healthcare with my skills in silkworm genetic engineering not only promises to elevate my career through advanced training and project management but also to develop a gamechanging silkbased product for biomedical applications
tablet games for early detection and intervention of developmental dyscalculia

the ultimate goal of the project is to provide a screening and rehabilitation method for the early detection and treatment of developmental dyscalculia dd in the form of an entertaining tabletbased gaming environment dd is a common learning disability and severely impacts personal and professional development throughout the lifespan early diagnosis and interventions increase the possibilities for people with dd to live an independent and productive life children with dd have difficulties to map numbers representation into space in contrast typically developing children understanding of numerical concepts is facilitated by spatial mapping of numbers we want to develop a tool which will use a gaming environment to evaluate and stimulate space number association sna in children kids will be stimulated with gamelike sna tasks and monitored with more general mathematical skills tasks we will link the device with an online algorithm for online extraction of the responses that can compute and analyse each kids performance to track it as it changes over time this project builds on two behavioural tasks i have established to implicitly assess sna in children and infants these paradigms can become a firststage screening tool for individuals at highrisk for dd we will further advance this method into a tool that allows easy rapid and automatic testing of spacetonumber processing in young children from any cultural and educational background and in any context the paradigms will be embedded in a gaming environment which is optimally engaging for the young users facilitating the spontaneous participation in foundational numerical training targeted to the needs and specific numerical competences of each child moreover we will further validate relationship between sna and core numerical competence development providing initial crucial steps for empirical validation of our method as an early screening tool for dd
trust and privacy preserving computing platform for crossborder federation of data

as we live in a datadriven era the emergence of interdisciplinary geographically dispersed data repositories is inevitable the fact that these repositories do not necessarily abide with existing interdisciplinary data representation standards nor do they necessarily belong to any data federation initiative renders them unusable since researchers cannot easily access this data moreover most of the times integrity privacy and security in such interactions is either very difficult or impossible to maintain towards this end trustee aims to bring a green secure trustworthy and privacyaware framework that will aggregate various interdisciplinary data repositories such as healthcare education energy space automotive crossborder etc and also consider other european data federation spaces and transnational initiatives such as gaiax and eosc trustee will offer a securebydesign framework wherein stored data is homomorphically encrypted thus offering researchers i ability to search and use data in the encrypted domain ii a unified and meaningful fair representation of data in an open and fair manner iii complex and contextaware queries through advanced ontologies iv data processing and analysis through transparent trustworthy ml workflows over an intuitive ai playground which will promote ai explainability interoperability and reusability by utilizing state of the art methods and paradigms v compliance with european privacy and ethical frameworks eg gdpr pia etc vi enforce privacy by applying a homomorphic encryption layer through which all data interaction will take place vii a blockchainbased transaction recorder to ensure accountability trustees fully encrypted solution will be validated through six different use cases supporting gaiax eosc egi etc demonstrating a multidisciplinary paneuropean federated fair and private data ecosystem
deciphering the role of the mycobacterium tuberculosis exometabolome in mycobacterial virulence

mycobacterium tuberculosis mtb the causative agent of tuberculosis tb exhibits an intracellular lifestyle thriving within host macrophages this remarkable ability to evade macrophagemediated killing and withstand the challenges posed by the host environment hinges largely on its exceptional capacity to adapt its metabolism in response to the diverse conditions encountered during infection despite progress our comprehension of mtb metabolic adjustments in these circumstances remains limitedpreliminary investigations conducted within the host laboratory have unveiled that mtb releases a multitude of small soluble molecules into its extracellular milieu when cultured in vitro these metabolites potentially exert a substantial influence at the hostpathogen interface subsequently shaping the delicate equilibrium established between the bacterium and its host throughout the course of infection this proposal is centered on elucidating the role of mtb exometabolome at hostpathogen interface with the overarching objectives of i advancing our insight into mtb metabolism and ii pinpointing potential novel virulence determinants that might be secreted by the microorganismthe primary phase involves the comprehensive identification and quantification of metabolites present in the bacterial culture medium this will be achieved through untargeted metabolomics methodologies primarily utilizing nmr and mass spectrometry subsequently the metabolic pathways governing the biosynthesis and secretion of these metabolites will be characterized this investigation seeks to unravel the underlying metabolic drivers facilitating the release of these compounds the culmination of this project involves exploring the impact of a subset of significant metabolites on the physiology of infected macrophages as well as their role in modulating the immune response these assessments will encompass a spectrum of in vitro and in vivo strategies
the map of redox intracellular signaling in skin physiology

the skin is the widest organ of the human body despite this the mechanisms that underline its regulation are relatively poorly understood many skin diseases are characterized by defects in the control of lining renewal or reestablishing barrier integrity after the disruption thus dissecting the signals that underpin the maintenance of skin homeostasis and regeneration are of pivotal interest for medicine recently redox signaling as described to have a crucial role in these processes indeed h2o2 the major signaling molecule of redox biology is not only an essential second messenger involved in skin proliferative and survival pathways but also it is reported that mild er stress cursing with an increase in organelle redox potential is needed for efficient reepithelization recently we have shown the presence of different erlinked h2o2 fluxes that orchestrate cellular redox responses in normal conditions and after the induction of er stress in hela cell lines in this scenario i propose to unveil the compartmentspecific h2o2 fluxes that regulate the redoxstasis during keratinocytes differentiation with particular emphasis on those that arrive from the endoplasmic reticulum er indeed the er is one of the major contributors to cellular redoxstasis harboring sources internal regulators and distributors that vehicle redox signals back and forth to the er in particular i divide this project into two main aims i characterize the role of intracellular redox fluxes during keratinocytes differentiation both in 2d and in 3d models ii identify the interactors of erderived h2o2 flux in skin cell lines and characterize the downstream pathways importantly a systematic analysis of the timing thresholds and targets of redox signals in skin pathways is a paramount gap in the field that has not yet been tackled and thus constitutes the principal aim that this project wants to undertake