Dragon09/odtu_chatbot huggingface dataset:
development of high entropy ceramicpolymer composite by ultralow temperature sintering for highfrequency related applications

the search for microwave materials with tailored dielectric properties in millimeterwave frequencies has been the objective of a significant number of manuscripts reported in the literature dielectric ceramics with lowloss dielectric thermally stable and low permittivity have received extensive attention owing to their significant application prospects in microwave communication systems it is therefore desirable to introduced new production techniques new compositions or improves the properties the proposed research will intellectually contribute to the scientific literature through the preparation and characterization of new dielectric materials belonging to the diopside camgsi2o6 based ceramics this proposal seeks to achieve the following specific objectives 1 consideration of the impact of different types and concentrations of dopant such as sr and ba for large divalent cation ca and zn co mn and ni for small divalent cation mg via high entropy strategy on the structural microstructural and microwave dielectric characteristics of camgsi2o6 based ceramics 2 evaluation of the effect of thermal annealing time and temperature on the final performance of high entropy camgsi2o6 based ceramics 3 to explore the relationship between high entropy design and microwave dielectric properties 4 fabrication of camgsi2o6 polyethylene pe composites using cold sintering process and investigation of the pressure temperature and transient solvent type on densification microstructure and microwave dielectric properties state of the art and new experimental techniques and methods will be used in order to achieve the goals of this proposal
a new framework for landscape research in archaeology

neflara a new framework for landscape research in archaeology is an interdisciplinary project that will help address landscape archaeologys most fundamental challenge the inherent uncertainty in archaeological reconstructions of past landscapes as a result of the fragmentary nature of archaeological data landscape archaeology studies the relationship between past societies and their environments computational and other methods in archaeological landscape research and the humanities more broadly focus almost exclusively on spatial elements although there is a clear notion that time and histories are fundamentally connected to the landscape yet this dominance of space in landscape research suffers from the major challenge of the fragmentary nature of archaeological data particularly when this data comes from a nonsystematic regional survey as opposed to systematic total area survey while landscape archaeology has benefited from computational developments a protocol to overcome the embedded uncertainty on spatial data is absent by defining best practices identifying optimal methods and outlining clear protocols for different datasets and spatial analyses this project will create a new robust quantitative framework for more accurate computational models of past landscapes improving their reliability and enhancing their interpretative potential to achieve this neflara will focus on three methodological gaps 1 the lack of validated methods for quantifying the uncertainty of nonsystematic regional archaeological data and models 2 the poorly explored field of research combining spatial analysis statistics and geographical information systems gis and network analysis to study nonsystematic regional databases and 3 the lack of a best practice guidelines and method pipelines for geovisual representations that take into account uncertainty in multiscalar spatial data
next generation nanoparticlebased antibacterial treatment for infected wounds

every 5th person with diabetes develops chronic wounds that are frequently infected by bacteria in 1527 cases bacterial wound infection leads to the gangrene that requires an amputation of the leg 10 mln of amputations occur annually showing that existing wound infection management treatments are inefficientnextnano aims to commercialize a new antibacterial nanotechology developed by our scientists and medical doctors to reduce the number of infectionrelated amputations by 20 we showed in animals studies that our first product produced on the basis of this technology an antibacterial wound dressing is 8x times better than the current commercial best women techeu grant would support the transition of our technology from the research and development stage to the commercialization stage for that we have 4 objectives 1 to upgrade the commercialization strategy of our company 2 to conduct the clinical assessment of our first product antibacterial wound dressing 3 to establish the quality management system qms in our company and 4 to train participants the main project results will be the improved commercialization strategy including new contacts with the stakeholders collaboration with the eu key opinion leaders and established qms that will greatly increase the connectivity and competitiveness of our womenled deeptech startup within innovation ecosystems of the eu this will lead to more inclusive and gender equal innovation ecosystem in eu since estonia is one of the eu inclusiveness target countries and has one of the eus highest inequalities between the salaries and top positions of women and men according to eurostat not least nextnano will result in significant impacts environmental decreased use of antibiotics societal 20 less amputations and economical 10 mln eur revenue by 2026 and new high valueadded jobs for 15 persons such as scientists medical doctors engineers and sales managers
energetics of quantum correlations

the proposed project energetics of quantum correlations aims to establish a comprehensive framework for studying quantum correlations and thermodynamics in continuous variablesthe key research goals established within this project encompass the creation of a universally applicable operational framework delineating the relationship between entanglement and energy manipulation this framework should be readily employable within the quantum technology sector additionally the project aims to conceive practical applications for harnessing energetic quantum advantages lastly it seeks to formulate an experimental plan for assessing the proposed theoryto achieve these goals the project leverages the expertise of both the hosting institution universidad de buenos aires uba and the partner institution icfo furthermore the project emphasises knowledge transfer and collaboration during the outgoing phase the researcher will collaborate closely with prof pazs team at uba gaining insights into quantum thermodynamics and correlations in the return phase at icfo collaboration with prof acns quantum information theory group will involve advanced analytical and numerical methods for characterising quantum correlations the project places a strong emphasis on skills transfer the researcher will actively engage in cosupervising phd and masters students enhancing supervisory and management skills teaching activities at both institutions will improve pedagogical abilities while participation in interdisciplinary initiatives will foster networking and knowledge exchange in addition the project is committed to develop energy efficient quantum technologies aligning with the msca green charterwith a strong foundation in theory and practical experiments coupled with a commitment to sustainability and knowledge exchange it is wellpositioned to make significant strides in our understanding of quantum correlations and their role in energy processing
inequalities in decisionmaking at critical junctions in life the role of ability signals for sorting and selection

school track decisions university or major choice and initial job finding are all decisive for seizing life opportunities when individuals from different socioeconomic groups make different highstakes decisions at these critical junctions this can reinforce existing inequalities and lead to lockin effects that are difficult to undo later in life understanding decisionmaking at these stages is thus fundamental to analyse and tackle inequality of opportunityindividuals and evaluators make critical educational or occupational decisions under imperfect information due to uncertainties about true ability and future productivity to resolve uncertainty ability signals and their interpretation both received and sent are crucial components of decisionmaking sorting and selection opportunity analyses the role of ability signals such as grades standardized tests certificates degrees or cv information for inequalities in highstakes decisionmaking under uncertainty and inequalityreinforcing statistical and stereotypical discrimination by socioeconomic background to this end it will draw on i experimental methods in lab and field to study the role of social environment and ability signals for unequal educational and occupational choices ii administrative records to obtain information about absolute and relative ability signals grades and degrees awarded at various institutions over time iii econometric techniques that help exploit exogenous variation to make causal inference about the role of ses and different ability signals for efficient sorting and selection opportunity will promote an innovative research agenda providing novel answers on how to mitigate the unfair and inefficient allocation of talent it will inform about policies that provide resources or changing ability signals to enhance equality of opportunity one of the most urgent topics in europes diverse aging and increasingly segregated societies
making information understandable for everyone

cfs consulting franchise sales gmbh founded as a role model for combining social impact and entrepreneurship is specialised in language simplification and accessible informationour leading brand capito creates a disruptive aibased text simplification system which transforms any text into comprehensible personalised information we reshape public and private communications the social sector and the digital machine translation industry we serve all target groups as we create 3 understandable language levels cefr a1 a2 and b1 the outcome is a barrierfree and tailored information for all adults who are not able to understand complex language more than half of the adults worldwide according to oecdcapito represents the core pillar of an accessible society enabling citizens with disabilities learning difficulties and low language skills to take independent decisions improve their communicational skills and knowledge and integrate them into the labour market
synergetic integration of biotechnology and thermochemical catalysis for the cascade conversion of organic waste to jetfuel

the reduction of ghg emissions according to the paris agreement is particularly challenging regarding the production of green liquid fuels with a high energy density for the aviation sector dropin biokerosene in this context the bioctane project aims to develop and optimize an innovative process for the conversion of organic waste materials naturally characterized by a highwater content eg foodwaste organic material from the food processing industry into carbonneutral marketready dropin jetfuelsin particular bioctane project will develop a proof of concept on the synergetic coupling of biotechnological and thermocatalytic processing routes by a disruptive and interdisciplinary strategy that will result in an efficient valorization of the organic wastes into renewable jetfuel maximizing the recovery of chemical energy nutrients and carbon use first the complex organic waste will be converted into platform molecules acetoin and 23butanediol by creating a breakthrough link between biotechnological processing of biowaste and hydrothermal gasification technology subsequently a novel onepot chemical process will be developed by the combination of different catalytic steps through which the platform molecules are converted to jetfuel range hydrocarbons based on an extensive process flow modelling the process efficiency and the technoeconomic requirements for full market integration as well as the environmental impact will be assessed best environmental performance including recovering nutrients for reuse will be aimed for throughout the process developmenttherefore bioctane will establish a novel pathway involving hybrid processes and multifunctional catalysts contributing to implement sustainable secure and competitive renewable energy technologies in europe boosting the use of advanced biofuels and with a direct impact on strategic areas like aviation transport
the sustainability indicator framework to communicate responsible aquafood production and consumption patterns

citizens decisions are central to living within the limits of our planet purchasing choices can drive change at retail and raw commodity levels but the complexity of fish and seafood food chains health benefits and risks and climate impacts need to be simplified and made more accessible and readily comparable currently there are no standardised ways to inform citizens about the various health issues nor are there guidelines or harmonised indicators for sustainable european fish and seafood products verifish will offer a framework of verifiable sustainability indicators for communications about sustainability based on fair data from eu and global aquafoods repositories brought together through the extraordinary collaboration of europeanwide actors like nofima eurofir and poseidon leveraging on this indicator verifish will design develop and disseminate a number of media products to help citizens seafood consumers and retailers associations and policy makers make informed consumption choices nofima domain experts will work with renowned scientific communicators from eurofish and experienced community builder trustit publish a good practice recommendation framework on neutral indicators to communicate sustainability along different consumer segments aquafood retailers seafood and aquaculture producers and associations as well as guidelines for their use in retail and horeca hotels restaurants catering a prototype web application will digest indicators into an accessible easy to use comprehensive media product for user communities including citizens summarising nutrition sustainability and biodiversity aspects the framework will be open access and will be tested via a series of related enduser engagement campaigns targeting younger generations via flashcard games for kids calendars and maps of seasonal fish for retailers and consumers and sustainable food influencers chefs on social media
dendrite assemblies as the core cortical computation module for continual motor learning

the cortex has the amazing capacity to continuously learn through experience while retaining past memories but how does the cortical network implement this continual learning while avoiding interference and catastrophic overwriting of prior events while cell assemblies with simple point neurons are thought to serve as the basic learning and storage units this model poses major challenges in dynamic environments and lacks experimental support relying on strong preliminary results i here propose a radically different view of learning and storage in the cortexthe dendrite assembly hypothesiswhere the relevant memory units are the hidden layer of dendritic branches namely each neuron operates as a small network with different dendrite assemblies representing different tasks and driving the soma the dendrite assembly model augments the cell assembly model potentially alleviating problems of interference sparsity and capacity we will test the dendrite assembly hypothesis in the mouse motor cortex where learning is perpetual and coding is dense this will entail determining dendritic and somatic representations during continual learning thus deciphering the core learning units of the network aim1 the pathways aim2 and structural plasticity aim3 that enable dendrite assembly formation and learning and the consequences of the dendrite assembly model for the pathogenesis of parkinsons disease aim4 we will record from somas dendrites and spines of pyramidal tract neurons at singlecell and population levels with unprecedented spatiotemporal resolution using stateoftheart invivo imaging a novel behavioral design and an analysis platform we developed our results are expected to transform our view of how cortical neurons represent multiple motor memories in the healthy and parkinsonian brain open avenues for developing novel treatment modalities for parkinsons disease and inspire new artificial intelligence network architectures
mechanism of protein kinases in biomolecular condensates

protein phosphorylation mediated by kinases plays a pivotal role in cellular regulation with kinase dysregulation strongly associated with diseases like cancer inflammation and neurodegenerative disorders alzheimers disease ad represents a significant global health challenge as the population ages at an accelerating pace a key pathological feature of ad is the accumulation of hyperphosphorylated tau which disrupts normal neuronal function emerging evidence suggests that tau undergoes liquidliquid phase separation llps potentially linking ad and biomolecular condensation moreover recent findings propose that llps intricately manages kinase signalling creating condensedphase structures biomolecular condensates that serve as recognizable sites for kinases however molecular mechanisms governing kinase behaviour within condensates are poorly understood the central hypothesis of kincond project is that the conformational landscape of protein kinases undergoes significant remodelling within biomolecular condensates controlling substrate selectivity and specificity this project focuses on the microtubule affinityregulating kinase mark2 a central player in the abnormal phosphorylation of tau kincond is meticulously structured into three work packages 1 investigating the specificity and reaction kinetics of mark2 within tau condensates 2 deciphering the conformational landscape of mark2 through advanced nuclear magnetic resonance methods and molecular dynamics simulations and 3 analyse the effect of biomolecular condensation on the conformational landscape of mark2 the outcomes of kincond are expected to provide crucial insights into the behaviour of protein kinases within biomolecular condensates shedding muchneeded light on the mechanisms of tau phosphorylation in ad furthermore the atomicdetail information obtained has the potential to open new avenues for the development of enhanced drugs targeting protein kinases
representative reliable and reproducible in vitro models of the human testes

western society is on the brink of a fertility crisis whereby human sperm counts have dropped by 59 over the past four decades and are projected to reach zero by 2045 treatments for the primary causes of male infertility have no scientific basis with urologists relying on ineffective empirical medical strategies guess work identifying effective male fertility treatments requires appropriate preclinical models of the spermproducing testes that can establish a mechanistic basis for treatment choice dosage and duration preclinical models must accurately represent the organspecific tissue and be amenable to highthroughput experimentation with automated analysis to ensure that they provide representative reliable and reproducible data however current models necessitate manual lowthroughput methods and do not accurately represent testicular tissue as the pertinent tissue properties are unknown the urological field therefore lacks an appropriate model of the testes upon which to evaluate male infertility treatmentsthe applicant will address this gap by characterising the relevant properties of human testicular tissue and establishing their effects on resident cell function the resulting data will inform the development of a hydrogel material with properties tailored to match those of the native tissue microspheres of the representative hydrogel containing primary testicular cells arranged to mimic the native tissue structure will be fabricated using a highthroughput platform and analysed using an automated raman spectroscope thereby forming the first representative reliable and reproducible model of the human testes the re3model system will be validated against established in vitro models and used to determine the therapeutic mechanisms of current empirical medical strategies while also identifying and optimising the most promising treatment approaches as an exemplar application
balancing brain chemicals for boosting metacontrol

cognitive control enables us to flexibly adapt behaviour to achieve our goals given a constantly changing environment it is a hallmark of the human mind and exquisitely vulnerable in health and disease cognitive control often implies goaldirected instrumental effort to inhibit unwanted yet hardwired or overlearnt biases and is commonly associated with the prefrontal cortex pfc and dopamine da however the mechanisms of the broader construct of flexible cognitive control remain unclear the urgency of addressing this is evidenced by robust predictive associations between flexible control and consequential life outcomes for health wealth and wellbeing chemcontrol approaches the problem from a novel angle reconceptualizing it as metalevel decisionmaking between distinct control strategies i propose to shift attention away from the classic focus on instrumental effort implicating pfc and da towards a richer metacontrol framework that takes into account outcome controllability chemcontrol radically upgrades the value of an opponent cognitively effortless strategy that releases hardwired pavlovian biases implicating serotonin 5ht it redefines pfc function as making metalevel decisions between expensive dopaminergic versus frugal serotonergic strategies based on estimating outcome controllability we have recently validated a computational procedure for quantifying controllability estimates i will combine this procedure with i highresolution fmri to compare neural activity in da and 5ht systems and ii novel pet designs to compare da and 5ht release next i will use iii psychopharmacology and iv ultrasound neuromodulation to causally manipulate key model components chemcontrol will unravel the mechanisms of boosting metacontrol revolutionizing strategies for promoting efficacy and resilience in a rapidly changing world