Dragon09/odtu_chatbot huggingface dataset:
understanding the role and biogenesis of transfer rnaderived small rnas in plants

this proposal aims to explore the precise mechanism overall impact and complete population of the small rnas derived of transfer rnas tsrnas in plants the proposed research would be carried out in a laboratory that specializes in rna regulation and that made substantial contributions to the plant trnaderived srna field dr german martinez although it has been described that these molecules are highly expressed in stress conditions we still lack a clear understanding of the biogenesis pathways that lead to tsrna accumulation as well as of the array of biological processes they influence and their mechanism of action additionally because of the widespread presence of rna modifications in these molecules the unbiased genomewide quantification is not possible with the conventional sequencing technologies therefore these molecules represent a largely uncharacterized stressresponsive regulatory network in plants and thus an exciting source of potential applications for agriculture the experimental approach of this project will use a model plant arabidopsis thaliana in order to characterize the tsrna population and evaluate the importance of this regulatory layer under viral stress first a method to compare the accumulation profiles of tsrnas based on the enzymatic removal of rna modifications will be implemented second the biogenesis pathway of trnaderived srnas will be studied using mutant plants and how this affects viral infection will be evaluated with these mutant plants third the genes targeted by trnaderived srnas will be identified using a combined approach based on the immunoprecipitation of crosslinked ago proteins and ribosome profiling that determines the translation rate overall the data that this project would obtain has the potential to shift our understanding of tsrnas and provide cuttingedge applications for agriculture thus the completion of this project would provide me a considerable professional maturity
bio2skin the first clinically skinpreserving biomaterial replacing siliconesacrylate as medical skin adhesives

external medical devices such as ostomy pouches wound dressings or wearable electronic devices require the use of medical adhesives for their attachment to the skin however prolonged use of current medical adhesives is associated with serious adverse skin reactions marsi medical adhesivesrelated skin injuries this underreported issue is prevalent in 25 of wound care cases and is associated with enormous health care and economic burdens bh4u aims to address this challenge with bio2skin a patented revolutionary glueless medical adhesive that uses the natural features of the skin to establish a waterbased link and overcomes the disadvantages of acrylicsilicone adhesives bio2skin is a biobased costeffective recyclable solution offering gentle safe adhesion and kind removal the product with a potential of 250m eur by 2030 will be sold under license to medical adhesive manufacturers and external medical devices manufacturers
optimised runway centreline interception

orci will explore innovative aibased solutions to help increase runway throughput using advanced automation support tools in the tma domain specifically the objective is to provide key information to air traffic controllers in final approach sectors to support informed decisions on when to issue vectoring instructions to aircraft for optimal spacing between consecutive arrivals during medium high very highdensity and increasingly complex tma airspace operations to achieve this objective the project will develop an ai model that is trained using radar surveillance data and atc voice communications between pilots and controllersduring the project barcelona and lisbon approach operations will be assessed this will include interviews with atco experts from the respective ansp partners as well as indepth analysis of local arrival characteristics eg geometries procedures etc in addition high amounts of radar surveillance and voice communications data will be collected and processed to support and guide the training and testing of the ai modelsthe validation of the ai model will be supported by human in the loop and fast time simulation techniques using the rams plus tool to ensure that the performance of the ai model is evaluated in a realistic and controlled environment and to get some initial human performance and safety related feedbackthe successful implementation of the ai model is anticipated to optimize delivery of vectoring instructions leading to enhanced capacity efficiency environmental performance and overall improvements to arrival air traffic management that are consistent with sesar performance targets additional benefits also extend to optimization of the runway throughput by reducing both atc workload and the potential for human error the expected solution could also be extended to incorporate the use of timebased separation for arrivals and digitally shared trajectory information coming from the flightdeck
degradation of micronanoplastics in water via fentonbased advanced oxidation processes under intensified conditions

plastic debris including micro and nanosized particles is considered a top environmental problem that might affect human ability to preserve biodiversity and the availability of safe water supplies in the future hence there is a clear and urgent need for the development of targeted treatment processes for the effective removal of micronanoplastics mnps from water although advanced oxidation processes aops have been widely studied for the treatment of different emerging and recalcitrant water pollutants their application for mnps removal have been scarcely addressed among them fentonbased aops display significant implementation advantages which will be explored and optimized in the present project the main challenge consists in mineralizing pollutants that do not dissolve in water and were designed to be hardly degradable to face this problem plasticox pursues the development and intensification of advanced treatment strategies such as homogeneous fenton and photofenton processes to age and mineralize mnps in water this project seeks to tackle many of the knowledge gaps in the research field of this hot topic the mnps degradation will be assessed in terms of fragmentation polymer deterioration process efficiency intermediates identity and kinetic models based on particles with decreasing diameters moreover the effect of particle size shape and composition will be explored in depth my unique research background which includes material science catalysis reactor engineering and a preliminary training in polymer science will allow me to perform this ambitious project moreover i will collaborate and learn from my supervisors who have a vast experience in the field the marie curie fellowship will enhance the potential of my future career perspectives empowering me to take leading positions in the field of wastewater management worldwide moreover i expect to develop a lasting scientific cooperation with the european host group
archaeological coastal heritage past present and future of a hidden prehistoric legacy

dn arche trains 10 phd fellows for increasing the scientific and public value of europes archaeological coastal heritage focusing on the legacy of stone age hunterfishergatherers including some of the earliest remains of human activity this legacy is crucial for understanding human engagement with the coast yet it is fragile and highly heterogeneous with diverse material and cultural expressions it is embedded in a variety of geographic settings across europe differing in environmental development which face massive environmental and human threats it is also approached in various ways in cultural heritage management with little systematic integration of knowledge on the topic dn arche deals with the challenges of this fractured field with an innovative pastpresentfuture approach which focuses on connecting the legacy from the past its present status as archaeological heritage and prospects for its future protection and integration with six beneficiaries and nine associated partners arche unites academic research centres and nonacademic organizations cultural heritage sector specialist organisations museums media as a joint platform for research and training it leverages on customized phd projects crossfertilization of knowledge among researchers and partners scientific courses workshops conferences applied secondments and transferable skills training training in archaeology anthropology critical heritage studies heritage management bioarchaeology geology oceanography coastal engineeringpreservation and communication relevant to coastal heritage and environment equips arche phds with advanced interdisciplinary and crossregional knowledge and skills applicable to various academic and nonacademic fields across europe through best practices they will contribute to the visibility preservation and sustainable integration of the vulnerable cultural heritage in coastal areas facing global environmental and development challenges
exploring the urbanism of roman mediterranean ports from iconographic data to 3d reconstruction

under the roman imperial period mediterranean port cities were not only transit hubs where ships people and goods both departed and arrived but also places of urban and cultural life developing away from the seafront they formed a real urban landscape with enough characteristics of complete cities whose aesthetic and monumental features were widely emphasised in iconography although these highly codified images are not snapshots of reality previous doctoral research assessed the documentary value of iconographic evidence for understanding roman portscapes by inevitably confronting them with archaeological and textual data urbaport exploring the urbanism of roman mediterranean ports from iconographic data to 3d reconstruction is an interdisciplinary project that aims to understand the urban and architectural morphology of roman maritime port cities and to propose reliable virtual reconstructions of these environments to achieve this goal urbaport will propose an innovative reflection that will consider how iconographic evidence could be integrated to the digital tools for expanding the scientific value of historical restitutions in order to replace maritime activities in their architectural context urbaport will bring together an unprecedented combination of advanced computational methods 3d modelling and smart generative methods developed by the cnrsmc maparia laboratory ecole nationale suprieure darchitecture de lyon with the recent archaeological data conducted at portus the port of the imperial rome by the ecole française de rome in the perspective of a virtual exhibition at the archaeological park of ostia antica
crete renewable energy valley

crete valley aims to create a renewable energy valley living lab revlab in crete it is envisioned as a decentralised renewable energy system that combines leadingedge ict technologies interoperable and open digital solutions including data sovereignty social innovation processes and sound business models that are easy to adopt crete valley will demonstrate a digitalised distributed renewable low carbon landscape that is affordable for all and fully covers the local energy needs on an annual basis utilizing multiple renewable energy carriers and leveraging energy storage technologies the revlab will integrate four community energy labs cels located in distinct sites across crete valley conceived as innovation hubs an integrated social technological business approach will be deployed providing a social science framework for revlabs cels innovative multilevel governance models socialdriven mechanisms for involving citizens in the codesign implementation and exploitation of res aibased market segmentation algorithms mcda methods and consensus analysis for rev configuration interactive tools for rev planning rev readiness assessment computation augmented reality applications decision support tool energy data space compliant digital backbone for consumer and revlevel datadriven activation p2p dltblockchain digital marketplace for tokenised energy and nonenergy assets valuation and reciprocal compensation datadriven operational analysis advanced aiml tools and flexibility modelling services for optimal operation resilience of the local energy grid systemofsystem dig twin for multiple carrier grid management operation datadriven services and apps for energy efficiency and activation performance management towards energy autonomy enabling res technologies to increase the power production rev business sandbox and blueprints for revlab setup upscaling and replication including 4 follower communities
origins and consequences of hematopoietic stem cell memories

hematopoiesis has long been modeled as a stepwise hierarchical process where all blood cells arise from a single group of rare multipotent stem cells for decades various reports have contested this unifying paradigm indicating that hematopoietic stem cells are functionally heterogeneous and differ on the rates and types of blood cells that they produce however the origins of stem cell heterogeneity and importantly its physiological consequences have remained ambiguous my recent research suggests that individual stem cell behaviors are deterministic and programmed through longlasting epigenetic memories but how these different stem cell memories arise during development or injury is currently unknown intriguingly my preliminary results indicate that stem cell memories instruct not just their fate decisions but also the functional properties of their mature progeny thus raising the question of how stem cell memories create functional patterns that bias the cellular responses of their mature progeny thus the objectives of memoristem are 1 to uncover the mechanisms that establish the diversity of hsc memories during development 2 to identify the molecular determinants that maintain specific hsc properties and 3 to characterize how developmental and acquired hsc memories determine functional patterns in mature blood cell responses to overcome various challenging aspects of studying cell memories in vivo i have designed a groundbreaking approach that combines innovative mouse models for transient gene silencing multiplexed clonal analysis and molecular recorders of cellular states in sum memoristem will precisely define the origins mechanisms and physiologic consequences of hematopoietic memories thus allowing a conceptual leap forward in regenerative and stem cell biology harnessing the programming of stem cell memories may help in the development of in situ cell therapeutics to treat chronic inflammation aging and cancer
cultivate crops with a fleet of electric agroecological robots that preserve the soils

a growing portion of cultivated soils is suffering from severe compaction as a result of an intensive use of heavy thermal tractors and yet there is no alternative to these tractors and no other solution can deliver the same level of productivity whilst avoiding compaction and massive co2 emissions consequently soil productivity is declining threatening food production in the long term sabi agri develops the first collaborative electric agroecological equipment where a fleet of unmanned lightweight robotic vehicles follows a leader vehicle driven by the farmer to multiply work capacity whilst alleviating the ground pressure up to 15 times compared to thermal tractors this fleet named swarm is co2 emission free it implements agroecological practices in various crops for any type of soilcultivation task this is a first timersabi agri will scaleup the collaborative robotic technology and industrialize the swarm before market uptake in the eu and the us
computational mechanisms of teacherpupil knowledge transfer

teaching is one of the most complex and efficient forms for social learning as it largely mitigates the costs of individual learning through the capitalization of others experiences however while recent efforts have shed considerable light into how human learning is computationally modeled very little is known about how human teaching can be computationally implemented in the context of goaldirected behaviours compteach is an innovative research program conceived to bridge this gap by combining cuttingedge methods in cognitive science experimental and social psychology with stateoftheart techniques from reinforcement learning rl and natural language processing nlp it aims at understanding the computational makeup of pedagogical knowledge transfer between experienced learners teachers and novel naive learners pupils compteach will first identify actors choice strategies as indexed by model parameters and evaluate the extent to which pedagogical texts crafted by teachers and addressed to pupils lead to meaningful parameter correlations between the two secondly the action will implementnlp tools to identify how the teachers own computational strategies are encoded in the semantic and syntactic structures of pedagogical texts finally the project will study how the teachers own learning process and metacognitive features affect knowledge transfer by tackling teaching from a computational perspective without losing sight of its sociocognitive underpinnings compteach will produce a novel quantitative understanding of experience transfer and establish novel bridges between teaching cognitive science social psychology and computational modeling future directions of this project will involve studying knowledge transfer in individuals afflicted by lasting underlying health conditions and the development of ecological experiments to approach teacherstudent and doctorpatient realworld interactions
mitochondriaer communication by contact sites during plant stress responses

it is common knowledge that an ethernet connection is safer than a wireless connection and cellular organelles share this approach to communicate directly among each other organelles are thought to use membrane contact sites mcs the optical fibers at the intracellular level organelles are in a prime position to sense and communicate stress signals due to their tight integration into the cells metabolic networks interorganelle communication is thus crucial to pass on the message to coordinate cellular stress responses and maintain homeostasis i hypothesise that mcs allow fast and efficient communication of stress signals between intracellular organelles eg mitochondria and er to coordinate the cellular stress responses however the organelle tethering proteins the stimuli driving mcs formation and the signalling molecules mediated through these mcs remain elusive in plants in intercom i will characterise ermitochondria communication in response to stress in arabidopsis thaliana for that i will leverage the host labs previously established ermitochondria communication model system and establish a proteomic screening setup to identify novel proteins involved in ermitochondria mcs in plants in addition i will develop a highthroughput platform to study interorganelle interactions in vivo and to identify stimuli driving mcs dynamics finally i will employ genetically encoded biosensors to pinpoint ros and calcium interorganelle signalling events to reach my goal i will combine my expertise in intracellular signalling and bioimaging with cuttingedge interactomics livecell imaging and highcontent technologies available at the host institute this innovative and interdisciplinary approach will allow me to shed light on plant interorganelle communication a field still in its infancy in plant biology with the potential to pave the path for the biotechnological engineering of plants more resilient to harmful environmental conditions
tests and applications of a peripheral interference theory of reading

reading ability is essential in modern society yet for many people it comes with considerable difficulty and to cognition scientists it remains rather mysterioushere i outline a plan for testing and applying a novel cognitive theory of reading the plan expands my recent model pong snell 2024 psych rev with a groundbreaking perspective on visuospatial attention to capture many reading behaviours wp1 the exciting prospect is that pong in a single stroke informs three big debates parallel processing wp2 positioncoding wp3 and peripheral interference wp4in wp2 a novel combination of eyetracking and eeg gazecontingent rapid invisible frequency tagging gcrift will provide a firstever direct window on the attentional distribution during readingit is konwn taht yuo cna raed tihs fnie but many readers also fail to see the error in do love you me the topic of word position coding is new to the field and pong predicts key roles for attention and statistical learning herein wp3 uses gcrift to track their relative contributions in time and space propelling a firstever unifying account of letter and word position codingpong predicts that letter and word recognition is hindered by surrounding text and possibly this is more severe in dyslexic readers wp4 tests pongs new account of dyslexia in which diffuse attention plays a causal role an exciting element here is my new reading interface iris the interface that reduces interference using saliency readers view texts while their eyes are tracked fixated words are shown at a higher contrast than surrounding text preliminary results show strikingly faster reading upgraded iris will tune its parameters to individual readers on the basis of incoming oculomotor data this holds both theoretical and practical promise testing dyslexic and nondyslexic readers iris parameters will reveal reading profiles to inform specific treatments and to further bolster the pong theory
fluorescent boroncluster dyes as biocompatible photosensitizers with promising antimicrobial and anticarcinogenic activity

the increasing resistance of microorganisms bacteria virus fungi against antimicrobials and antiseptics is one of the most challenging topics in current medicine and biology statistics from the centre for disease control and prevention suggest that bacterial resistance to antibiotics causes over 20000 deaths every year in eu member states alone the european centre for disease prevention and control ecdc alerts that healthcareassociated infections caused mainly by multidrugresistant mdr bacteria remain a public health issue and emphasizes the importance and urgency to search for effective alternative approaches based on completely different mechanisms one of the promising approaches to fight against infections is the antimicrobial photodynamic therapy apdt using biocompatible photosensitizerscompared to classical antimicrobials the biggest advantage of apdt is the very low probability that the target microorganisms have the opportunity to develop resistance furthermore apdt can be synergistically combined with other antibacterial treatments such as radiotherapy antibiotic treatments and photothemal therapy to improve its antibacterial efficiency the main goal of this project is to engineer novel boron rich biocompatible photosensitizers with suppressed interactions and herewith enhanced for efficient singlete o2 production to be used in a twofold objective a as apdt agents for the inactivation of microorganisms in sanitary instruments and medical devices b as antitumor agents in dual pdtbnct cancer therapies the innovation is focused on the development boron content pss with multiple applications both for antimicrobial apdt and anticancer pdt and bnct