Dragon09/odtu_chatbot huggingface dataset:
diabetic neuropathy a study on the effects of insulin resistance on its pathophysiology and a randomized clinical trial to prevent neural loss

we are facing a global epidemic of type 2 diabetes t2d diabetic neuropathy dn is the most common complication of t2d affecting 50 of patients with t2d if not diagnosed early dn may lead to further catastrophic complications however despite its potentially huge impact on patients quality of life and burden imposed on healthcare systems patients with t2d and practitioners are often unaware of the manifestations of dn to make things worse currently there are no approved treatments for dn sensediabetes has several aims first we wish to increase our knowledge regarding the pathophysiology of dn specifically assessing whether patients with t2d and dn have worse insulin resistance compared to patients with t2d without dn while previous studies on dn have shown an effect of insulin resistance on dn poor indexes of insulin resistance have been used in sensediabetes we will use for the first time the gold standard method for the assessment of insulin resistance ie the euglycemic insulin clamp second we will assess the efficacy of two commonly used antidiabetic drugs in early dn patients with t2d and early signs of dn will be randomized to receive treatment for 9 months with either semaglutide or empagliflozin the effects of these drugs on dn outcomes small fiber density cardiovascular autonomic function and advanced glycation endproducts will be assessed further we will study with ex vivo experiments the effects of the two drugs of peripheral nerve density obtained with skin biopsies and in in vitro experiments we will study the exact mechanisms of action of semaglutide on cultures of peripheral nerves along with the scientific part sensediabetes has a dedicated wp to increase awareness of dnsensediabetes may thus be pivotal for the development of new strategies to combat dn also sensediabetes aims to promote awareness of dn and thus increase societal impact through early recognition of dn and prevention of further complications
critiquing assessements of decisionmaking capacity

the focus of this project is what it is for an agent to be able to make a decision and when we should count them as being able to do so this is a question that has received sustained attention throughout the history of philosophy and there are many different theories and models of decisionmaking on offer different views of decisionmaking can have huge practical impact in various legal and medical contexts decisionmaking capacity is assessed in order to determine how people are viewed and treated including whether they are fit to stand trial have the right to refuse medical treatment or are viewed as criminally responsibledrawing on a range of philosophical psychological cognitive scientific and psychiatric literature this project will aim to evaluate different philosophical theories of decisionmaking the novel contribution of this project and its particular methodological focus will be to focus on assessing theories of decisionmaking by their practical impact an important but oftenneglected metric for assessing philosophical theories and conceptsas well as further elucidating and clarifying the core question of the nature of decisionmaking two key benefits of this project are envisaged first a substantive contribution to the question of how decisionmaking ought to be assessed in the relevant legal and medical contexts for example one key focus of the project will be the neglect of external influences social and environmental in facilitating decisionmaking where currently in many contexts they are treated solely as potential hinderances secondly the project will bring recent work in philosophy of science on pluralism to bear on the question of how legal frameworks and decisions are and ought to be informed by relevant scientific and empirical research and expertise given their different focuses goals and explanatory interests and the impact that this has on their conceptualizations of relevant phenomena
start start talking about research today

trinity college dublin has coordinated european researchers nights every year since 2013 building on this rich experience of public engagement and researcher development the start project team will once again coordinate an event across multiple partners and locations in 2024 and 2025 start will spark deeper more impactful engagement with the public and bring researchers and citizens together in dialogue about the role research and research careers play in our everyday livesbased on the idea start talking about research today the start partners will create a project that will activate various sites around ireland to highlight the fact that research happens everywhere and takes many forms start will provide an opportunity for the general public and researchers to engage with each other in new ways through a combination of inperson and virtual activities demonstrations tours talks and more start will promote the idea that research is a living fundamental part of our society that impacts on and involves everyonestart will work to achieve a number of specific goals 1 create new dialogues between researchers and the general public that will lead to a deeper more profound and sustained engagement with each other 2 raise awareness of research and research careers as positive forces in our society 3 highlight the role of the european union in supporting research and discoverypublic engagement and communications workshops will be offered to all mscafunded researchers in the first instance as well as other participants in the events on the night a series of activities and showcases will be held across a variety of locations to raise awareness in the months preceding european researchers night the start project group has a wealth of talent and experience in public engagement activities including previous ern events and the project team will draw on this expertise to ensure that start 202425 is grounded in best practice
a climatic or tectonic control on early primate dispersal a new approach to investigate species dispersal in deep time

recent studies show that the distribution of many modern terrestrial species can be explained by a handful amount of largescale dispersals and that these episodes will likely become more numerous under climatic stress however the underlying mechanisms governing these dispersals remain nebulous longdistance dispersals across marine barriers often referred to sweepstakes dispersals have always been assumed to be an unpredictable process in which taxa overcome a geographic barrier in a random manner yet there are many instances of dispersals across marine barriers that appear coordinated and nonrandom new paleontological findings show that during a short time period marked by intense climate variations 40 to 35 million years ago asian anthropoid primates and rodents crossed 500 km of tethys sea to reach africa and 800 km of south atlantic ocean to reach south america this proposal aims to build an empirical and theoretical basis for the origins and mechanisms of longdistance dispersals by resolving how did primates and other mammals disperse across two major seaways what are the external forcing mechanisms that make transoceanic dispersals nonrandom this project proposes a combination of paleoclimatic paleogeographic and paleontological approaches to evaluate the mechanisms of species dispersal and diversification in deep time applied to the early dispersal of anthropoid primates this research will set the founding steps of a holistic method to evaluate the mechanisms of all dispersal events in deep time allowing new interpretations about the modern past and future distribution of species it will additionally solve one of the biggest mysteries in paleontology as this episode ranks among the most pivotal events during all of primate evolutionary history
dynamic decarbonization pathways framework integrating technological social and policy innovations for sustainable renovations in the built environment

the building sector holds a prominent position in energy consumption 40 and co2 emissions 36 within the european union moreover current construction and renovation practices are huge raw material consumers and highly waste producers despite the efforts on an eu scale renovation rates are far below the minimum required now only reaching around 1 of the building stock per year these drawbacks bring forward the impact of rising material extraction shrunk global circularity from to 72 in 2023 to facilitate closing this performance and designtomarket gap in the built environment deco2 aims to address the compelling need for advancing innovative technological applications and solutions on the built environment focusing on building elements materials products and technologies the project also aims to set up solid and longlasting partnerships within the legal and regulatory framework and other stakeholders addressing the whole value chain for socioeconomic innovation facilitating to close the performance and designtomarket gap including for historical and cultural heritage buildings a wellsegmented audience targeting developers policymakers and the construction industry will ensure effective market penetration as deco2 is projected as an aligned solution to the eus sustainability aspirations collaborative engagement showcasing tangible benefits and dedicated digital presence will embrace the entire buildinglife cycle and all the relevant stakeholders involved in each innovation action stage of renovation projects materials and techniques targeting trl 8 that contribute to space users overall health and wellbeing comfort and inclusivity
gammaneutron vision aimed at improved cancer treatments in hadron therapy

proton therapy represents one of the most recent and adavanced tools in cancer treatment especially for complex cases and pediatric patients despite its exponential deployment worldwide hadron therapy still faces two main limitations which are related to i accurate ionrange verification and ii assessment of the secondary unwanted neutron dose the present proposal presents an innovative tool that can help to improve this situation and thus increase the potential benefits of hadron therapy this project focuses on a portable device that can simultaneously image both gammarays and thermal neutrons which are ineluctably produced during the treatment on one hand imaging thermal neutrons may help to quantify more reliably the secondary neutron dose received by the patient during therapy complementary gammaray imaging is accomplished with the same apparatus by means of electronic collimation thus enabling realtime assessment of the ionrange in terms of gammavision the system has been recently tested in preclinical conditions at cnaseville and hitheidelberg this poc project aims therefore at demonstrating the additional neutronvision capability thereby elevating the full gnvision system to trl6 and addressing its commercial viability in the healthsector
the role of the hyporheic zone on the transportertransformer functions of river corridors

reactive substances transported in river corridors undergo several transformations having important implications for the fate of toxic chemicals and the health of fluvial ecosystems delivery of substances into the slow and geochemicallymicrobially rich hyporheic zone delays their downstream transport and promotes opportunities for biogeochemical reactions the resulting delay and reactivity at larger scales are shaped by the ubiquitous heterogeneity of environmental porous media and the temporal fluctuations that typify river corridors which control transport and mixing limitations in the reactive regions of the hyporheic zone however the most widespread upscaling pictures neglect these fundamental aspects assuming either a transient storage in a wellmixed hyporheic zone or pure advective transport along noninteracting hyporheic streamlines the paradigm of oversimplification leads to severe shortcomings such as limited transferability of findings and great uncertainty in largescale predictionshypor pursues a paradigmshift ground the upscaling of reactivetransport in river corridors on the mechanistic knowledge of the hyporheic dynamics first we will improve the understanding of heterogeneity and temporal fluctuations controls through comprehensive numerical investigations at small scales second this will allow to quantify on a physical basis the stochasticity in the transport and mixing limitations of pointinjections green functions as they encounter reactive regions the stochastic evolutions of green functions will be the building block of a novel reactivetransport upscaled model to overcome current shortcomings yet the hidden nature of the hyporheic zone leads to uncertainty third hypor will exploit the link between smallscale uncertain properties and physicsbased upscaling elements in a new uncertainty analysis framework that propagates uncertainty at small scales onto largescale predictions quantifying their reliability
inquisitive modal logic

modal logic is at the heart of an incredibly fruitful interdisciplinary enterprise it is used to formalize reasoning about key notions like knowledge and belief obligation and permission action and outcome and finds important applications in computer science ai economics and linguistics in its current form modal logic builds on truthconditional semantics which analyzes meaning in terms of truth conditions this is the source of two limitations first there are important modal notions whose argument is not a proposition but a question since questions do not have truth conditions these notions cannot be analyzed in existing modal logics second much recent work indicates that natural language modals are sensitive not only to the truth conditions of their argument but also to the different alternatives it presents thus making distinctions that are invisible to truthconditional semantics the aim of this project is to develop a new framework for modal logic that overcomes these limitations
training in translational protocols for minimal invasive diagnosis and therapy in pancreaticobiliary cancers

the overall aim of the project is to strengthen the strategic partnership of the university of medicine and pharmacy carol davila bucharest umfcd romania one of the widening countries with two internationallyleading counterparts at the eu level region h copenhagen university hospital herlev denmark and university college london uk to enhance networking activities among these institutions and to combine their skills and competences in the field of minimal invasive endoscopic interventions in pancreaticobiliary diseases translated expertise in the form of training and educating earlystage researchers esr in the field of minimally invasive endoscopic interventions is needed to increase the number and quality of innovative services at umfcd and its clinical affiliated hospitals the proposal is the result of a longstanding collaboration and joint multicentric research projects performed by the partners of the consortium thus in the past 20 years there was a sustained clinical research activity in the field of minimally invasive endoscopic procedures supported by various national and international grants of the key persons involved in the trip proposal one of the key wps of the trip proposal is represented by a multicentre protocol for a research project on pancreatic organoid cultures derived from endoscopic ultrasound guided fine needle biopsy eusfnb specimens with consequent pharmacotyping used for personalized therapy of pancreatic cancer patients the project partners will thus transfer their expertise to umfcd with an emphasis on phd students and esrs this knowledge transfer and capacity building will be achieved through joint research activities and academic collaboration enhanced staff mobility education and training activities workshops summer schools and dissemination events last but not least one of the concrete deliverables of the trip proposal is represented by the upgrading of the research management unit at umfcd
multiactor research and innovation approaches for functional food

keeping up with the dramatic increase in worldfood needs is a challenging task food supply is further affected by the latest consumers dietary trends driving demand for food products of enhanced nutritional value defined health benefits increased safety and proven environmental sustainability ria4food will tackle these challenges by proposing a new framework for functional food design ria4food will utilise sea buckthorn berries as source of bioactive compounds in conjunction with stateoftheart methodologies from different disciplines to showcase a scientificallysound way of making food products functional and of proven added health value which can sustain nutritional needs of all consumer groups healthy diseased obese children athletes etc utilising humanrelevant in vitro dietary and disease models and a complete metabolomic epiproteomic and proteomic analysis the project will assess the physiological pathways affected from sea buckthorn consumption these profiles will be then put under rigorous machine learning analysis to produce algorithms that will calculate the correct amount of bioactive ingredients needed to confer the desired health benefits and will thus facilitate the design of new functional products more importantly ria4food will also explore new technologies to deliver fresh sea buckthorn health benefits to the market as snacks of increased shelflife for this the osmotic dehydration methodology will be put to the test metabolomic epiproteomic and proteomic profiles of osmotic sea buckthorn consumption will also be produced and compared to the respective profiles of the fresh fruit finally additional predictive algorithms will be computed to provide effective feedbacks to both the primary farming sector and the processing sector thus fostering the optimisation of the new proposed food value chain
understanding the role of economic imagination for advancing decarbonization in europe

how do we imagine the decarbonized economy of the future while research suggests that opposition to climate mitigation is often driven by economic concerns we have little systematic knowledge of how decarbonization is actually imagined as a socioeconomic transition nor do we know about the economic images symbols narratives and assumptions underlying such visions and fearsreimagine brings economic sociologys recent interest in economic imaginaries and imagined futures to the study of climate inaction its overall aim is to comparatively analyze and theorize how economic imagination fuels conflicts frictions and impasses of decarbonization in europea novel theoretical framework centers on social imaginaries of the economy a concept describing shared representations of what the economy is and ought to be it allows capturing and comparing economic imagination related to decarbonization but can also explain enduring contestation with reference to dissonant economic imagination visions of decarbonization that convey contrasting understandings of the economy restrict resonance between positions make it hard to form coalitions or even recognize mutual interestssubstantiating this framework an ambitious mixed method analysis explores decarbonization controversies within and across five eu societies ireland germany poland sweden spain we will a analyze media discourses and imagery to understand national frictions and develop a typology of decarbonization imaginaries b guided by visual prompts interview local and national representatives from business administration and climate initiatives to understand how economic imagination plays into conflicts of implementing decarbonization c apply correspondence analysis to interview results to chart major european fault lines and surprising coalitionsoverall the project advances our interdisciplinary understanding of decarbonization and reveals challenges to a common european mitigation strategy
maximizing the tax revenues from the automatic financial account information exchange system

tax evasion represents a pervasive phenomenon and a substantial portion can be attributable to income held abroad the general consensus at global level is that crossborder tax evasion can be fought effectively by further increasing information exchange between countries anecdotal evidence suggests that introducing a system for the automatic exchange of information aeoi is extremely costly yet we lack a direct assessment of the related benefits taxfair aims to analyze the effectiveness of the aeoi system to mobilize tax revenues and to determine the characteristics of an aeoi system that maximizes tax revenue extraction specifically 1 i will create a highquality novel dataset based on administrative data on norwegian residents and a dataset containing institutional information on locally implemented aeoi systems 2 i will apply stateoftheart regression models to the administrative dataset to quantify the tax revenue recovered from the introduction of a aeoi system 3 by combining the institutional information dataset and the administrative dataset i will empirically analyze the traits that maximize the tax revenues recovered from the local aeoi systems overall taxfair will provide a knowledge based framework for governments and policymakers which will allow them to increase the monetary resources highly needed for financing the recovery from the massive negative economic shock induced by the covid19 pandemic while working on the action i will develop new methodological skills especially on machine learning crosssectorial skills through the research stay at the imf stronger communication skills by presenting at international conferences and via video clips and further teaching and organizational skills especially by organizing a case study competition joint with the industry overall the msca fellowship will undoubtedly jumpstart my career allowing me to emerge as an independent researcher with multiple attractive career pathways
holistic energy management and thermal waste integrated system for energy optimization

the heatwise project aims to tackle various thermal management challenges in tertiary buildings with a significant it load the project has specific objectives to develop and validate to trl 4 and 5 its technological innovation in two interrelated aspects for it system equipment in facility rooms and for a complete building management level the innovation toward achieving energy efficiency and thermal management optimization follows up on a detailed thermal need analysis framework and theoretical validation and is fulfilled through four novel solutions i hybrid futureproof cooling hardware solution for highdensity data processing based on twophase dielectric liquid cooling and air immersion ii digital twinsupported holistic highdensity data processing management system with a smart workload orchestration system iii integrated multiobjective building energy management system covering both it equipment needs and human presence and iv selfassessment tool for energy management needs in tertiary buildings with powerintensive it systems on top of that the project will develop a knowledgesharing platform to showcase potential improvement pathways in energy optimization of tertiary buildings and maximize the projects impact the project consortium consists of 12 partners from 8 different countries across the eu and with a more global inclusion including 3 universities 3 research centers 4 smes 1 large company and 1 national standardization body making sure that all the required expertise for a successful accomplishment of the project and future exploitation exist and the partners complement each other in the most optimal manner the technologies will be demonstrated in different specific designs and integrations in a university a supercomputing research centre industrial and office buildings in denmark poland turkey and switzerland with extended investigations for medical centres and hotels as impactful tertiary building categories