Dragon09/odtu_chatbot huggingface dataset:
turbulence and interactions with dispersive equations and fourier analysis

the turbulence of fluids and waves is one of the most important mechanisms that govern our environment affecting air travel prediction of ocean surface or weather forecasting even if simulations are used every day to predict turbulence its accurate mathematical description is one of the biggest open problems in mathematical physics on the other hand dispersive pdes are central objects in mathematical analysis and are among the most successful models for several physical phenomena in this project i propose to advance in both theories turbulence and dispersive pdes by studying their interaction the project is divided in two work packages each focused on one direction of such interactionwp1 to advance in the rigorous mathematical treatment of intermittency and multifractality central concepts in turbulence the approach proposed is to identify them in the vortex filament equation the 1d schrödinger map on the sphere and the nonlinear schrödinger equation nls wellestablished models connected through the hasimoto transformation and directly related to fluid and wave turbulence respectively this is a novelty with respect to previous works which mainly focus on abstract often isolated mathematical objects wp2 to study the pointwise convergence problem to the initial datum one of the most important problems in dispersive pdes and fourier analysis from a novel probabilistic approach coming from fluid and wave turbulence this is motivated by recent progress in wave turbulence which has put forth the value of probabilistic techniquesto solve the problems techniques from fourier analysis pdes and probability complemented by number theory and geometry will be required for this i will have the support and training of two cosupervisors experts in complementary areas in harmonic analysis and pdes besides the project will benefit from interdisciplinary collaboration with physician experts in turbulence
a patch of land reconsidering work as a lifesustaining practice in the postsocialist semiperiphery through intergenerational childhood memories

patchwork explores work in the context of sustainable land cultivation in the postsocialist semiperiphery as a lifesustaining practice embedded in morethanhuman relationality reciprocity and care through the lens of intergenerational childhood experiences the project aims to open up alternative trajectories towards sustainable coexistence with our living environments through work and to develop a theory of work that is not caught by mere economic rationality but is embedded in a human andmorethanhuman relationality three central approaches contributing to the retheorization of work underlie this project 1 thinking through childhood memories approach enables to document and examine mundane intergenerational sustainable practices and human and morethanhuman relationalities that fall outside of contemporary sciences attention 2 a postsocialist decolonial approach that seeks to bring into view those knowledges and practices that have been subjugated by western environmentalism and contest necro and turboneoliberal capitalism and its land practices 3 an intersectional approach to age gender and social class that allows for an analysis of gender relations and social class in relation to childrens participation in sustainable practices patchwork employs an innovative interdisciplinary methodology that includes sensory walks collective biography workshops citizen science and secondary analysis from previous ethnographic fieldwork retheorizing work as the main outcome of patchwork will contribute to scientific advances across disciplines with two coauthored articles an englishlanguage monograph and a museum exhibitionpatchwork will contribute to retheorization of work to the inclusion of childhood in mainstream theory and to the development of a knowledge base on traditional and sustainable land cultivation practices
targeting swisnfrelated chromatin remodelling defects in solid tumours

recent largescale genomic profiling studies have uncovered mutations in the swisnf switch sucrose nonfermentable chromatin remodelling complex subunits in 20 of solid tumours most of these tumours resist to current therapies to address this highly unmet medical need it is crucial to determine how to harness vulnerabilities induced by swisnf defects recent evidence shows that swisnf influences the dna damage response and is involved in shaping tumour immunogenicity though whether there is a link between these observations and whether the latter may be therapeutically exploited is unknown further the impact of swisnf defects on tumour heterogeneity a major determinant of resistance to treatment remains unaddressed i therefore propose to identify and understand synthetic lethal vulnerabilities associated with two selected swisnf defects of unmet need pbrm1 and smarcb1 and to further study how the latter can be exploited to stimulate the antitumour immune response by using hypothesistesting and generating approaches including highthroughput screening on inhouse developed isogenic and nonisogenic models i will identify and decipher novel synthetic lethal vulnerabilities associated with pbrm1 and smarcb1 defects molecular biology highcontent imaging and in vivo experiments will be performed to study the effects of drugs that cause synthetic lethality both on intracellular signalling and on antitumour immune response i will further characterise the impact of smarcb1 defects on tumour heterogeneity using single cell sequencing on preclinical models and human tumour samples preclinical data will be integrated with tumour profiling and clinical data and will guide the development of proofofconcept clinical studies as i previously did the overall research program will identify decipher mechanistically and evaluate clinically novel immunooncology therapeutic strategies for selected swisnfdeficient tumours of unmet need
data privacy in digital markets

focusing on verifiability privdima studies the regulation of data privacy to protect consumers from excessive price discrimination in digital marketsprivdima breaks with previous literature by acknowledging that data has a verifiability effect it proposes a study of data privacy regulation by explicitly modelling this verifiability effect its motivation is as follows 1 data collection in digital markets renders private information verifiable 2 due to unravelling this verifiability effect of data impacts regulation at a fundamental level 3 extant work on privacy regulation abstracts from the effect 4 data privacy rules that ignore verifiability effects lead to misguided regulation privdima is to rectify thisprivdima has 3 objectives objective 1 is to incorporate verifiability in the stateoftheart theories of mechanism and information design readying them for the analysis of a new range of problems where verifiability matters objective 2 is to derive concrete policy implications for data privacy based on regulating the use of data to limit price discrimination it yields new insights on regulating both long and short run contracts in models of behaviourbased price discrimination objective 3 is to derive concrete policy implications for data privacy based on regulating the collection of data it yields insights on how to prevent an unravelling of private information by which the verifiability effect of data hurts consumers objective 1 implies a major advancement for the field of economic theory objectives 2 and 3 ensure that consumers obtain a fair share of the benefits from digitalization promoting not only equity and fairness but also public support for future digitalization allowing societies to reap its benefits while avoiding social conflictas privdimas pi i have a proven track record in developing and applying the required methods and expertise in working with both verifiable and nonverifiable information
illuminating bodybrain communication channels at the choroid plexus and their impact on brain physiology

in contrast to other organs the brain is surrounded by a system of specialized anatomical barriers isolating it from direct contact with immune cells and microbial products present in the blood however such factors do dynamically shape brain function in homeostasis and disease because of this unusual anatomy the pathways of bloodbrain communication are still poorly understood while this understanding would provide a fundamental insight into brain function regulation and enrich the current knowledge of neurological disease mechanisms my previous work suggests that the choroid plexus cp is a central player mediating the influence of immune and microbial signals on the brain the cp epithelium is a monolayer barrier tissue which on the side facing the blood has the ability to sense such peripheral factors and on the side facing the brain produces the cerebrospinal fluid csfa liquid carrying nutrients and signaling molecules which contacts nearly all brain cells and ensures brain homeostasis i therefore hypothesize that peripheral immune and microbial factors may shape brain function indirectly via regulation of the csf properties at the cp epitheliumbased on our preliminary data and building on my past expertise in cp biology neuroscience and immunogenomics here i propose an interdisciplinary project braingate striving to illuminate the physiological mechanisms and roles of gutbloodcpbrain communication axis during postnatal development aim 1 under conditions of microbiota perturbation aim 2 and along the circadian cycles aim 3 by developing new tools for cpspecific genetic perturbation and combining them with approaches of spatial transcriptomics and behavioral readouts in mouse models this project will reveal fundamental principles of physiological regulation of brain development function and maintenance and pave the way for future investigation of the gutbloodcpbrain communication circuit in neurological disease
strongcouplingenhanced nanoparticle array organic light emitting diode

we propose a radical new solution to the problem of increasing the efficiency of organic lightemitting diodes oleds based on modifying the lightmatter coupling by nanostructures all previous attempts to increase the efficiency of oleds to be competitive with commercial inorganic leds have failed if successful our new vision for strongly coupled organic lightemitting diodes scoleds will bypass the existing technological bottleneck oleds can be fabricated from earthabundant nontoxic materials using energyefficient processes in stark contrast to the present marketleading inorganic leds however despite their much lower environmental impact the widespread deployment of oleds has been blocked by their limited efficiency to achieve the required stepchange in efficiency plasmonic nanoparticle arrays will be used to enhance the coupling between light and matter within oleds our objectives are to enhance oled efficiency to a level competitive with inorganic leds and at the same time to adjust the periodicity size and shape of the nanoparticles to control the color polarization and directional distribution of the emitted light analytic theory numerical simulations and nanofabrication will be combined with optical and electronic characterization across an interdisciplinary team with expertise ranging from materials science and electronics to photonics and quantum physics including worldleading proficiency in nanoparticle arrays and strong lightmatter coupling our ambitious target is the proofofprinciple demonstration of an oled with more than 50 external quantum efficiency and tailorable control of the properties of the emitted light scoleds offer the prospect of a breakthrough technology that will dramatically reduce the environmental impact of led technology in lighting and display applications and will widen the palette of oled applications to new and emerging areas such as electronic vehicles augmented reality and urban agriculture
high q factor miniaturized low mass accoustic filters for highly demanding space applications

the homemade project falls directly into the scope of the horizon europe policy to reduce the dependence on critical technologies and capabilities from outside europe for future space applications we target a fast growing market which integrates communication satellites in 5g networks that will reduce digital divide by meeting latent demand for digital broadband the project aims at developing a truly new surface acoustic wavesaw filter technology not yet available to space industry this innovation based on piezooninsulator poi wafers already produced for smart phone industry is not accessible to space industry due to market size and its own high reliability specificities compared to existing technologies poibased saw filters enable high integration temperature stability thermal management low insertion loss and high rejection with various bandwidths in l and sband frequencies replacing leaky waves on usual piezoelectric substrates by real guided waves on siliconbased wafers this project will deliver as first pillar poibased saw filters for space industry up to a trl7 addressing all volume demands in line with geosynchronous earth orbiting satellites to low earth orbiting satellite constellations the supply chain for key items such as poi wafer supply to frontend and backend process is based in europe the high demand of innovation yielding reduced mass in satellites especially for new growing markets within a limited access time has pushed to develop in homemade a second pillar that will deliver disruptive poi based saw filters able to compete with bulky mechanical filters the value chain includes european supplier of specific acoustic passive soifrec as part of the soitec group with space integrator and technology supplier tas ucl and sme inc both world leaders in the field poi based material and device optimization and finally alt european centre of excellence for space reliability of high complexity active and passive components
meet research to connect science and society

the role of science in our societies is strongly related to the creation of new knowledge to face the big challenges of our modern world the improvement of education and the increment of life quality however science and technology are often hidden from nonexpert eyes generating a gap between citizens and scientists to thrive science requires support communication and discussion the coscience project aims to connect science to society by promoting the importance of research and innovation by making science education attractive for youngsters and by providing researchers with effective communication tools bringing them closer to the citizens the way to achieve these goals will go through 1 the implementation of public spaces where researchers and citizens meet face to face 2 the empowerment of researchers in their communication skills 3 the establishment of an ecosystem of people and institutions working together to engage citizens in science and 4 the public recognitions boosting of research and science education the proposal is supported by a consortium of formal and informal learning institutions working together with institutional and civil stakeholders for effective and lasting public engagement and new and appealing opportunities to interact with citizens the coscience project will specifically train researchers on the enhancement of their communication skills and it will organize two ern editions implementing educational initiatives in the schools erns will be implemented in six important cities of lombardy in italy milano como varese busto arsizio lodi and lecco creating crossdisciplinary and multitopic diffuse events on steam fields and promoting the european scientific culture during the related school years we will propose active learning actions in the schools owing to the presence of researchers among the students thus rebuilding confidence which is fundamental for our communities
travelling intelligence against crime and terrorism

leas use the data in their information systems as their basis for making decisions that affect the safety of european citizens according to a recent report of the european court of auditors on the eu information systems use it has been found out that individual countries have different perception and methodologies on how data management should be addressed officers from leas have stated that not all datasets are included in their systems while other data is either not complete and accurate or not entered in a timely manner the same report states that there are regulatory and cultural issues according to which some countries do not make all the functions offered in the central eu systems available through their national systems tenacity envisions to address these challenges by proposing a 3pillar approach a modern and effective tools for exploitation of travel intelligence data by security authorities tenacity proposes an interoperable open architecture for the integration and analysis of multiple transactional historical and behavioural data from a variety of sources by exploiting game changing digital technologies b training and sensitisation of leas personnel tenacity envisions the design of a living lab to be established to organise hackathons workshops for all relevant stakeholders who would benefit from the use of passenger data and digital technologies proposed c holistic approach to crime prevention tenacity vision is to implement and demonstrate a travel intelligence governance framework that will incorporate a holistic approach to crime prevention will ensure that the proposed digital technologies will support the identification of the modus operandi of criminal and terrorism organizations and will include policy makers in the governance process examining how the new tools will provide new capabilities to shape the regulations
development of an efficient and robust wireless inductive charging system for material handling electric vehicles

in the eu transportation of goods generates about 28 of total co2emissions and consumes 375 of total eu energy production current intra logistics systems include internal combustion engine ice vehicles plugin hybrid electric vehicles and evs however the incorporation of charging infrastructure for evs in logistics comes with cost and challenges within this context the magcharge is a unique solution that offers a combination of inductive wireless charging technology with the robustness of concrete which is vital for industrial applications the magcharge core element is the magpad a wireless power transmitter pad made using magments patented magnetizable concrete material which consists of a coil for inductive transmission whose efficiency is 95 it is also perfectly suitable for inductive charging roads as it works with any cover layer both concrete and asphalt
selflearning aibased transport optimization software as a service for the most complex logistics scenarios in realtime enabling doubledigit cost co2 and tyre wear savings

smartlanes aibased dispatch software logisticsbrain is a selflearning cloudbased software for automated transport optimization smartlanes core technology the scenariobased optimization ai algorithms in combination with kpi and process analysis optimizes costs by 40 planning time by 90 resources co2 emissions and fine dust by 21 and service quality logisticsbrain is the enabler of full automation for logistic systems and dispatching processes that so far still are based on manual processes sensitivity analyses offer global transport optima by computing several hundreds of scenarios in parallel in this project partial routes are linked to form a network flow by crowdsourcing this allows for real time optimization of transport simply using one software instead of more than three individual solutions as today transport logistics planning challenges are solved by standardized interfaces even for freight forwarders with complex it environments
exploring the role of nmda receptors in k channel nanoscale organisation surface dynamics and function

nmda glutamate receptors nmdar are undisputed key players in synaptic plasticity a role that has been attributed to their calcium permeability it emerged over the past decade that the membrane trafficking and nanoscale organization of nmdars also plays a major role in synaptic adaptation this was further substantiated by the discovery that patients autoantibodies targeting nmdars nmdarabs induce major psychiatric and neurological symptoms through compromised nmdar surface trafficking but intact ionotropic function nmdarabs rapidly alter nmdar membrane dynamics by disrupting their interaction with specific interactors whose membrane organization and function are also possibly corruptedherein i hypothesize that the whole surface interactome of nmdars which is still poorly defined is altered by nmdarabs explaining the complex neuropsychiatric presentation observed in nmdarabpositive patients to tackle this i will perform an unbiased proximity labelling approach coupled to quantitative proteomics to provide the first identification of the nmdar surface interactome in hippocampal neurons and determine how it is altered by patients nmdarabs among the targets the potassium k channels which tightly control neuronal excitability are of prime interest since they functionally interact with nmdars and preliminary evidence from the host laboratory show that nmdarabs alter hippocampal neuron excitability using superresolution microscopy and electrophysiology i will test whether nmdarabs modulate the membrane trafficking and nanoscale topography of k channels impairing k channel currents genetic or pharmacological modulation will be used to question the membrane interplay between nmdars and k channels in a pathological as well as basal contextthis original proposal will thus shed new light on the nmdar membrane interactome its dynamics at the nanoscale and implication in a severe neurological and psychiatric autoimmune paradigm
desmoplastic small round cell tumor on the spotlight introducing cart cell therapy

desmoplastic small round cell tumor dsrct is an aggressive rare sarcoma that occurs in adolescents and young adults dsrct has a dismal prognosis despite aggressive therapy 3year overall survival has been estimated at 44 and the 5year survival rate remains around 15 current therapeutic approaches including chemotherapy remain highly toxic and surgery are yet to achieve complete disease control the development of safe and efficient molecularly targetedtherapies as well as a comprehensive understanding of the molecular driver of the disease are highly needed to ultimately improve patient outcomethe originality of this proposal relies on intersecting complementary scientific areas as the high level of maturity i have acquired both on the molecular basis of dsrct and on the corresponding cellular and animal models and a novel form of immunotherapy as cart cells which the host group is actively working on for the treatment of dsrct it will be carried out under the guidance of prof moreira from cncuc who holds more than 25 years of experience in the field of targeted delivery to solid tumors and successful entrepreneurthis fellowship in line with europe mission on cancer is a life time opportunity that will enable me to become a highly qualified researcher with differentiated background combining existing molecular cancer pharmacology with targeting strategies to solid tumors and novel transferable skills among the postdoc universe entering the job market it will enable me to generate and integrate interdisciplinary knowledge with added economic value with knowhow on how to translate it towards the market and the patients overall these are relevant features to support the sustainability of any organization as such approval of this marie sklodowskacurie european fellowship will give me a wide avenue of opportunities to further pursue a career either in academia or pharmaceutical industry