Dragon09/odtu_chatbot huggingface dataset:
advanced circuits for detection and control of diamond quantum sensors

quantum sensors using nitrogenvacancy nv spin colour centres in diamond have made great strides from scientific curiosity towards practical applications first devices for example diamond scanning probe microscopes are on the market however large scale applications are limited by the availability of a compact hardware combined with the diamond quantum chip and their costeffectiveness acdcq tackles these challenges by creating a fully integrated system for control and readout of nv centres by making use of semiconductor technology the project builds upon a first demonstration of this integration oeaw infineon the device makes use of electrical readout of nv centres as pioneered by imec and developed by the applicants in previous eu projects further development of the integrated logic in acdcq will allow controlled excitation and spin manipulation devices the integration will lead to compact and costeffective realization while reaching stateoftheart performance comparable to devices constructed on an optical table the devices will be developed towards commercial applications in magnetometry including nondestructive evaluation kwanttek space magnetometry imec asi and remote monitoring thales the device performance will be calibrated in the precise eu metrology facilities ptb by bringing together pioneering academic research with cuttingedge semiconductor industrial processes and leading manufacturers acdcq will transform diamond sensors from laboratory experiments to prototypes developed to target commercialization
a predictive coding perspective of brain dynamics the case of oscillatory travelling waves

one of the most exciting yet puzzling questions in neuroscience is how the brain coordinates the activity between different areas integrating distinct representations into conscious percepts and thoughts for decades neuroscientists have investigated how the brain orchestrates diverse regions activity pointing at oscillations as one of the key mechanisms involved in such a process however previous research has mainly focused on the temporal aspect of oscillatory dynamics largely overlooking how oscillations propagate through the brain although rhythmic traveling waves have recently gained renewed interest their functional role and relation to cognitive functions remain largely unknown in this project i will address this fundamental question what is the role of oscillatory traveling waves in brain dynamics i plan to take on this challenge using a multiscale computational approach modeling neural dynamics within and between cortical regions as well as corticalthalamic interactions importantly the novelty of this approach consists in framing the model in the light of predictive coding principles to test the compelling yet striking hypothesis that traveling waves encode predictions and predictionerrors the results of the simulations will be compared against experimental recordings in human participants to validate and assess the models predictions lastly some implementations will turn into deep learning architectures to test their dynamics in visual tasks while improving current models of artificial vision all in all this proposal can significantly advance our understanding of the neurophysiological mechanisms involved in sensory and cognitive functions testing whether and how oscillatory traveling waves are a critical mechanism in neural dynamics and producing fundamental results in the scientific field and future technological applications
ligninolytic enzymes keys to unlock the hidden potential of lignin

context globally 5070 million tons of lignin a highly branched heteroaromatic polymer are discharged per year as a waste material from the paper and pulp industry despite being touted as the most abundant renewable source of different valueadded products on earth leaving 98 of lignin underutilized industries degrade only 2 of lignin and that also comes with environmentally hazardous thermochemical processesbackground recently the discovery of hemecontaining class ii fungal peroxidases viz lignin peroxidase lip manganese peroxidase mnp versatile peroxidase vp dyedecolorizing peroxidase dyp garnered a lot of attention due to their biodegradable ligninolysis however the industrial application of peroxidasebased lignin degradation still seems to be a farflung dream owing to low availability of peroxidases in sufficient amount enzyme instability in industrial effluent high enzyme cost and long process timesaims and objective i hypothesize that a cocktail of engineered stress tolerant active and stable peroxidases could lead to synergistic biodegradation of lignin to achieve this artificial intelligence ai tailored lip mnp vp and dyp will be cloned and expressed as inclusion bodies ibs in e coli using prof spadiuts expertise whereas mine will employ solubilization and refolding strategies to increase the overall yield of bioactive protein an ideal stoichiometric combination of engineered peroxidases will be standardized to withstand the harsh conditions of industrial effluent resulting in a sustainable and economic ligninolytic technologyconcluding remarks the project is inspired from nature backed with ai and stemmed with the expertise of mine and prof spadiuts in producing recombinant bioactive protein from bacterial ibs while tu wiens decades of experience in commercializing the technology will be a fertile playground to bow the seeds of a sustainable ligninolytic technology
traditional knowledge for the conservation of the silk roads monumental terracruda sculptures

it is in central asia that more than 2000 years ago the art of making monumental terracruda sculptures become one of the most significant expressions of knowledge transfer along the silk roads despite the wide distribution of this art and its historic relevance we still lack a scientific understanding of the manufacturing of these sculptures consequently preservation remains a challenge recent studies have shown that monumental terracruda sculptures are still produced in some areas of himalaya bhutan and india west bengal and although the precise materials may vary the technological pattern remains unchanged over time this pattern is the result of a specific knowledge acquired and transmitted over centuries tantric will study and valorise this traditional knowledge to unveil the cultural significance of this unique artistic practice as well as to inspire through scientific criteria innovative and sustainable solutions for the conservation of these sculptures tantric proposes an interdisciplinary methodological framework in the domain of heritage science combining ethnographic research materials science and conservation the objectives are 1 documenting the empirical knowledge of making these sculptures 2 analysing samples of archaeological sculptures to compare ancient and contemporary materials and additives 3 carrying out a battery of simulationstests to analyse the behaviour and properties of the claybased mortars inspired by traditional recipes the expected results will be a improving the understanding significance and evolution of the artistic practice of making monumental terracruda sculptures b enhancing and valorising the traditional knowledge for making these sculptures c informing new evidencebased conservation treatments d demonstrating that exploring the traditional use of green materials represents an innovative solution for the design of more sustainable and responsible heritage conservation strategies
identification of cellular regulators and pharmacological inhibitors of endophilina3 to modulate its endocytic functions

in addition to classical clathrinmediated endocytosis mammalian cells have clathrinindependent endocytic cie mechanisms among others the bar domain proteins that sense and induce membrane curvature are key players in cie in particular the bar domain protein endophilina3 endoa3 drives cie of the cell adhesion molecules cd166 l1cam and dicam with implications in tumour progression and viral infection the regulation mechanism and functional implications of this recentlyidentified endoa3mediated cie route remain poorly characterized in this context i propose an interdisciplinary project combining cell biology chemical biology and virology approaches to substantially advance our understanding of endoa3mediated cie the first research goal is to identify cellular regulators kinases phosphoinositides that modulate endoa3mediated endocytosis in parallel this project aims at identifying small molecule inhibitors that selectively inhibit the endocytic functions of endoa3 subsequently the cellular regulators and pharmacological inhibitors identified in this project will be used in cells to modulate endoa3mediated endocytosis and study the impact on cellular functions emphasis will be put on cancer cell properties and endocytic viral particle entry together this project will generate highquality fundamental knowledge on the mechanism and function of endoa3mediated cie moreover the identification of modulators of endoa3 endocytic functions will provide valuable biological tools for the study of this recentlyidentified cie route in physiology and pathology lastly the identification of selective pharmacological inhibitors may pave the way towards the development of innovative antiviral and anticancer therapeutics targeted at unconventional endocytosis this fellowship will be conducted in the laboratory of prof henrifrancois renard unamur belgium who has been a pioneer in the identification of barmediated endocytic routes
age of moderation liberal patriotism in the mediterranean 18141848

this project will investigate the transnational conceptualisation and diffusion of moderate liberal thought in mediterranean europe in the first half of the nineteenth century it will explore moderate thinkers formulation of a third political way for the future of europe between revolution and reaction by focussing on their transnational correspondence across france switzerland italy greece and spain while historians have largely neglected the study of moderation theory by regarding it as an unoriginal and selfserving strand of thought this projects overarching argument is that moderation theory was an original strand of liberalism which southern europeans in dialogue with their northern neighbours conceptualised and implemented as an alternative to the political challenges of the revolutionary age the proposed research presents two new dimensions first while historians have recently studied moderation theory in national contexts this project will be the first transnational history of moderation theory in nineteenthcentury europe the international scope of moderate liberalism and its application in different national contexts are revealing of its significance in postrevolutionary europe the second original dimension is that this project will use moderation theory to investigate the transnationalism of nationsinthemaking in the nineteenthcentury mediterranean as scholars have recently started studying the modern mediterranean as a transnational zone of contact this project will add a further dimension by focussing on moderation theory as a primary trigger for intellectual encounters in the mediterranean in the nineteenth century
deployable decisionmaking embracing semantics for robotic safety in everyday scenarios

recent breakthroughs in machine learning have opened up opportunities for robots to build a semantic understanding of their operating environment and interact with humans in more natural ways while machine learning has unlocked new potentials for robot autonomy as robots venture into the real world physical interactions with the surrounding environment pose additional challenges one typical challenge in practical applications is providing safety guarantees in robot decisionmaking much of the safe robot decisionmaking literature today focuses on explicit safety constraints defined in the robot state and input space however in practical applications robots are often required to infer semanticsgrounded safe actions from perception input while recent machine learning techniques are increasingly capable of distilling semantic information from perception translating the semantic understanding to explicit safety constraints is nontrivial in this proposed project we aim to close the perceptionaction loop and develop mathematical foundations and algorithmic tools that enable robots to make intelligent and semantically safe decisions
progressing promising skills to work in bulgaria proskills2work

the main goal of proskills2work is to raise the international research visibility of the institute of philosophy and sociology ips of the bulgarian academy of sciences and to develop its traditionally strong focus on sociology of education and work towards a worldclass level of research excellence this will be achieved by advancing scientific knowledge on the bulgarian vocational skills formation system continuous skills enhancement individual transitions from education to work and workplace learning alongside the respective methodological challenges the projects research component will advance scientific knowledge by further developing sociological concepts which allow for analysing the complex relationship of education and work in the current societal and economic context of bulgaria five specific objectives will guide the implementation of proskills2work 1 appointment of prof dr christian imdorf to establish and lead the era chair research unit 2 develop the research and innovation capacity of the ips towards international excellence 3 ensure the constant development of various skill sets and competencies among ips researchers 4 implement structural changes to create the conditions to achieve research excellence on a sustainable basis 5 position the ips as a hub for scientific excellence and policyrelevant stakeholder exchange on progressing promising skills to work through the institutionalisation of a future bulgarian observatory of education and work the increase of research capacity at ips by the era chair unit is expected to promote collaborations between research teams in the ips and external research groups as well as translating research results into policy recommendations and innovative models of vocational skills formation in bulgaria and the western balkans importantly this agrees with the recent european union eu and social partners commitment and upcoming action plan to address labour and skills shortages in bulgaria
integrated structural and probabilistic approaches for biological and epidemiological systems

systems in nature are extremely robust despite huge uncertainties and variability studying their nonlinear dynamic behaviour is challenging due to their complexity and the many parameters at play but crucial to understand important phenomena such as cellular dynamics onset of diseases epidemic spreadingparameterdependent simulations can predict the behaviour of natural systems case by case yet the exact models and parameter values are poorly known while qualitative behaviours are often preserved even with huge parameter variations because they rely on the system interconnection structure parameterfree structural approaches can check whether a property is preserved for a whole family of uncertain systems exclusively due to its structure however when an expected property fails to hold structurally novel approaches are needed to understand why which system features prevent it which key parameters must be finely tuned to enforce itinspire will develop a unifying framework to analyse and control families of uncertain dynamical systems in biology and epidemiology which integrates for the first time structural robust and probabilistic methods tailored to the peculiarities of natural systemsthe project will provide i methodologies to assess practically structural properties and unveil the mechanisms that enableprevent a property identifying the key parameters or motifs ii control paradigms that leverage such an insight to guarantee a desired global property through targeted local interventions iii scaling and aggregation approaches that exploit the properties of subsystems to mitigate computational complexitythe project outcomes a mathematical theory as well as algorithms to analyse and control complex uncertain systems in nature will strongly support the analysis and design of biomolecular feedback systems with a desired behaviour the identification of therapeutic targets the prediction and control of epidemic phenomena
energetic solar eruptions data and analysis tools

the soler project will investigate energetic solar eruptions starting from three perspectives fast coronal mass ejections cmes strong xray flares and large solar energetic particle sep events key parameters of the eruptions will be determined and their interrelations examined to improve our understanding on how the eruptive phenomena are linked how they interact with each other and how they result in acceleration of high energy particles and their release from the solar corona into interplanetary space largeamplitude coronal waves and shocks related to these events as well as magnetic connections of the radiation sources with the insitu observers will be in focus as wellsoler will answer three science questions what are the magnetic connections between em radiation sources in the low corona and in the high corona and how are they connected to the particle radiation observed in situ what is the relation of the properties of the insitu sep observations with the source characteristics and between the source characteristics themselves what are the reasons for the large variations in sep properties and associated flare and cme characteristicsrelated to these scientific questions soler has also technical objectives soler will deliver interlinked catalogues of strong flares fast cmes and large sep events deliver new tools for analysing and visualising solar eruption datasets and modelling results and distribute them openly to the scientific community produce several highlevel multiinstrument datasets and distribute them openly to the scientific communitysoler will use esa nasa and national mission data along with groundbased observations and a variety of innovative data and image processing techniques together with cuttingedge models soler analysis activities will directly lead to dozens of scientific publications catalogues datasets and tools will be openly available for the community for further exploitation of data
designing stretchable hydrogel electrolytes and 2dimensional mxene electrodes for energy harvesting via ionic thermoelectrics

recently energy harvesting technologies based on the concept of thermoelectricity with direct conversion of waste heat into electricity has received great attention thermoelectric te devices have already been used in various industries such as combustion engines coupled to photovoltaic cells and to power small home appliances conventional te devices based on electronic conducting materials working through the thermodiffusion of electrons and holes have been intensively studied and achieved significant performance innovations however the small electronic seebeck coefficient 100 v k1 limits their practical applications at the same time these devices cease to work as temperature difference diminishes and are not capable of storing charge most of them are based on hard inorganic materials with nolimited flexibility and are not applicable in wearable applications therefore it is necessary to develop new electrolytes with a high seebeck coefficient and large surface electrodes for high charge storage capability to solve these issues in this project we propose the development of stretchable hydrogel electrolytes and 2dimensional 2d mxene electrodes the proposal consists of 1 design and synthesis of the stretchable hydrogel electrolytes that exhibit intrinsic stretchability 300 and humidityindependent high ionic seebeck coefficient 50 mv k1 2 realizing 2d mxene electrodes capable of high capacitance 500 fg 3 fabricating energy harvesting and sensing devices based on ionic thermoelectric this project will give an opportunity for the researcher to gain stateoftheart knowledge on ionic thermoelectric materials and devices the experience of the supervisor in various thermoelectric generators will also be fully exploited through this project our proposal will contribute to materials science particularly in energy harvesting society polymer electrolytes and 2 dimensional mxene materials
a multidisciplinary and circular approach towards the development of innovative safebydesign biodegradable multifunctional coatings

despite the relevance of polymers eg coatings in modern societies the limited or absent biodegradability and recyclability associated with this class of materials pose serious environmental and health concerns addressing this challenge is thus a key priority being fully aligned with the eu green deal and the un sustainable development goals to bridge this gap a multidisciplinary team with researchers from seven countries including one associate partner has converged to achieve pioneer breakthroughs under the safercoat projectin this sense safercoat aims to promote staff mobility and knowledgesharing to develop ecofriendly polymeric coating formulations with enhanced biodegradability for aeronautical maritime and cultural applications safercoat will focus on the i synthesis and modification of thermoplastic and thermosetting polymers to accelerate their degradation rate at the endoflife ii optimization testing and validation of coating formulations for targeted applications iii assessment of the environmental and health impacts and iv upcycling of endoflife materials to produce addvalue products this scientific endeavor will rely on the synergy of specialized training and crosssector and interdisciplinary mobility among the 6 universities and 4 industrial partners to promote knowledge growth transfer dissemination and exploitationthe novelty of safercoat lies in incorporating high biosourced content and cuttingedge technologies to develop coatings with outstanding performance throughout the service life and high biodegradation after use which will contribute to i decrease the coatings industrys environmental footprint ii revolutionalize the coatings endoflife by transforming what is currently treated as a disposable waste into valuable products contributing for a zero pollution environment and iii settle an international rd network to ensure permanent progress on biodegradable and sustainable coatings