Dragon09/odtu_chatbot huggingface dataset:
singlet fission in fullerenebased singlematerial organic solar cells

photovoltaics is to date the most promising of all technologies to produce clean and renewable energy currently in use siliconbased solar cells have reached power conversion efficiencies as high as 26 but their fabrication involves expensive and contaminating processes moreover further improvement of their efficiency is restricted to around 30 by the socalled shockleyqueisser sq limit potential solutions to these problems may involve moving from inorganic to organic materials in this sense organic solar cells oscs represent a promising alternative to replace silicon because of their low cost flexibility and manageable nature singlematerial organic solar cells smoscs a particular class of oscs in which the donor and acceptor materials are covalently linked are particularly attractive because of their facilitated fabrication processes improved stability morphology and reproducibility on the other hand to enhance the efficiency beyond the theoretical sq limit the use of sensitizing singlet fission sf chromophores has been proposed these materials are able to form two triplet excitons from a single absorbed photon thus raising the external quantum efficiency of solar cells up to 200 the aim of the fullfission action is to combine the potentialities of both approaches to fabricate efficient smoscs that incorporate fullerenes functionalized with sf moieties as the active layer the fullfission action is conceived as a holistic approach that will combine computationallyassisted materials design synthesis and device fabrication in an interconnected and interdisciplinary project developed by a researcher with experience in all these disciplines
collaborative autonomous robots for emergency assistance

carma aims to cocreate through a usercentred iterative methodology involving a complementary set of endusers and ssh experts a groundbreaking modular and intuitive platform offering a complementary set of semiautonomous and autonomous ugvs capable of working in symbiosis with humans to support and supplement first responders and assist citizen in a wide range of disaster situations including those with very low visibilitythe project will build on the most advanced research results including those from the intrepid project in the field of disaster robotics making them autonomous thanks to novel 3d radarbased environment mapping and analysis combined with artificial intelligence for enhanced path and mission planning as well as victim and threat detection symbiotic operations and natural robothuman interaction will be made possible by exploiting generative adversarial networks for collaborative tasks natural language processing and extended reality technologiesthe project will evaluate the effectiveness and acceptance of the proposed platform in the frame of four ambitious pilots in complementary operational environments coordinated by a large european industrial leader in the crisis management market the consortium includes worldclass research centres in the domain of ai and social robotics robotics manufacturers professional and volunteer first responders as well as local authorities it is complemented by an international advisory board and an open community to ensure openness and diversity social ethical and legal constraints will be carefully considered during the projects lifetime in order to prepare the ground for broad adoption and successful exploitation of the projects results carma will implement an ambitious communication and dissemination plan an engaging training curriculum and produce a white book proposing recommendations for doctrine changes to involve the proposed solution in crisis management operations
high efficiency low emission nautical solid oxide fuel cell

the helenus project will build integrate and demonstrate a 500kw solid oxide fuel cell sofc module operating in cogeneration combined heat and power mode in an msc world class series ocean cruise vessel the sofc will be fully integrated spatially electrically and thermally into the ship design sofcs are the most efficient chemical energy converters available today and are also highly fuelflexible thereby remaining highly relevant for the future of waterborne transport the helenus demonstrator will achieve a trl of 7 at the end of the project with extended field testing already planned to reach trl8 by 20282029 success of this project will enable upscaling of mature sofc technology in ocean cruise liners to as high as 20mw by as early as 2029 this can unlock over 23 total fuel savings assuming a hybrid 20mw sofc60mw ice energy system over a stateoftheart energy system with only ices the helenus consortium involves diverse and accomplished stakeholders representing the entire value chain from technology development to field implementation creating a rapid pathway towards exploitation and commercialisationhelenus will also undertake extensive simulation experimental using an 80kw scaleddown sofc module and analytical efforts to demonstrate the applicability of the developed sofc solution i upon significant scaleup 10 mw and beyond ii over duty cycles of alternate applications such as dredging and offshore vessels and iii using carbonneutral fuels with potential for future maritime uptake experimental results will be complemented by application case and lifecycle performance analyses to assess the broader impact of the technology on waterborne transport therefore helenus creates a technological and regulatory roadmap towards a maritime future with scaledup clean energy systems operating on renewable fuels thereby fostering innovation and significantly boosting the competitiveness of the eu maritime industry
deepsea carbonates under pressure mechanisms of dissolution and climate feedbacks

as humanity grapples with the escalating crisis of climate change understanding and mitigating the sources of carbon dioxide co2 emissions is imperative a lesserknown yet significant aspect of this crisis lies in the vast expanses of marine sediments which encompass twothirds of the earths surface a key component of these sediments is calcium carbonate caco3 a family of minerals that makes up the shells and skeletons of marine organisms co2 emissions lead to ocean acidification triggering caco3 dissolution which in turn neutralizes co2 acting as a crucial co2 sink over millennial timescales however the mechanisms and rate of this dissolution remain unknown due to the challenges posed by the deep oceans high pressures and the elusive bacterial communities mediating the dissolution process proposed here is an ambitious fiveyear research initiative aimed at understanding deepsea caco3 dissolution thereby paving the way towards a more thorough understanding and potential mitigation of climate change impacts by focusing on the abyssal and hadal realms this groundbreaking research seeks to unveil the nature and rate of caco3 dissolution through high pressure reactors these reactors which mimic the pressure and temperature of deepsea environments present a robust alternative to infield studies with the integration of cuttingedge sensors and the use of advanced caco3 imaging techniques we anticipate generating precise and continuous data on the unfolding biogeochemical processes by housing bacterial cultures within the reactors alongside natural caco3 grains this project will delve into the mechanisms driving dissolution the insights will be instrumental in refining a global biogeochemical model thereby promoting a deeper comprehension of the oceans role in carbon sequestration and propelling forward the global efforts towards effective climate change mitigation
investigating if recuperating hepatic macrophage numbers and functions in chronic fibrosis can limit the incidence and severity of infections

liver fibrosis is the buildup of scar tissue resulting in impaired liver function it can have different causes including alcohol abuse obesity and viral hepatitis for reasons that we do not fully understand patients with fibrosis termed cirrhosis are more susceptible to infections in fact 50 of hospitalized patients with liver cirrhosis and infection die highlighting the scale of this problem macrophages mfs are immune cells present in every tissue of the body that function to eliminate pathogens in the liver one subset of mfs the kupffer cells kcs are perfectly equipped with scavenger and pathogen recognition receptors to do this moreover they are positioned in the bloodstream meaning they are one of the first cells to sense and respond to circulating pathogens although their precise roles have not yet been elucidated in cirrhosis kcs are reduced in number being replaced by distinct mf subtypes including a population termed lipidassociated mfs lams preliminary data from the host lab demonstrate that both kcs and lams from the cirrhotic liver respond less efficiently to infection when compared with their healthy counterparts thus i hypothesize that the altered mf landscape in cirrhosis and fibrosis is one mechanism driving the increased susceptibility and exacerbated responses to infection in these patients here i aim to test this hypothesis by examining how the different mfs respond to infection in the presence and absence of fibrosis using novel mouse models specifically targeting the distinct mf populations coupled with ex vivo cultures of human hepatic mfs i will tease apart the mechanisms through which mfs exert their effects and attempt to manipulate these to recuperate normal mf numbers and functions potentially uncovering novel therapeutic approaches to limit infection and improve cirrhotic patient health
dynamic spatiotemporal modulation of light by phononic architectures

imaging technologies form the basis of a vast range of products and devices and improvements would have a huge impact both scientifically and commercially we have identified a key bottleneck how light is modulated in the imaging system that we can unlock to achieve a new paradigm in imaging technologies spatial light modulators and similar components operate sequentially the light beam is shaped in different patterns but the time interval between patterns is limited by the refresh rate of the device we will remove this limitation thereby creating a technological breakthrough our advance will be to send all possible patterns of the device simultaneously and encoded in a short nanosecond pulse creating the concept of parallel beam shaping or dynamic spatiotemporal light modulation device in dynamo we will shape optical beams in two spatial dimensions plus the temporal one the equivalent refresh rate of the dynamic pixel will start at ghz although we are confident it will become much higher by the end of the project to give an idea of our ambition we compare this improvement in the time to process images with the improvement in the clock frequency of computers the first generalpurpose electronic computer the eniac had a clock frequency of 100khz in 1945 it was not until 2000 where amd reached 1 ghz in their computers processing images is broadly similar to processing data so this is indicative of the fiftyyear acceleration in the realm of imaging that we will achieve dynamo is an ambitious and integrated project that begins by studying the fundamentals of acoustic wave scattering and ends by developing ultrafast imaging applications in optics the success of this pathway requires the synergy of the disciplines of physical acoustics photonics and imaging the outcomes from this project offer to accelerate imaging technologies and place european science and industry at the forefront of the inventions and advances that will follow
moral residue epistemological ramifications ethical implications and didactic opportunities

this project is a contribution to moral philosophy to the didactics of transformative reading and to medical ethics education it examines moral residue mr the distress experience common among health care practitioners as well as other moral agents of recognizing what they take to be their own failure to meet a moral requirement despite not being fully blameworthy for that failure and which they express through regret or anguish our overall aim is threefold 1 to substantially advance the philosophical and phenomenological understanding of mr as a concept and as an experience by analysing situations of mr caused by moral dilemmas and by directing attention to situations that have not been explored or are underexplored mr caused by unavoidable normative ignorance or by impermissible emotions 2 to empirically study the impact of literary narrative fiction that is thematically related to mr in altering concepts of self and others a process we call transformative reading and 3 to devise and to empirically test the potential merits of a novel narrative method for medical ethics education that we believe can enable health care practitioners to learn how to acknowledge their inherent vulnerability to mr and to accept that they are likely to fail morally in ways that they may not be able to avoid without this acceptance compromising their sense of dignity as moral agents the aims are intimately connected in that it is the philosophical research into mr which motivates and enables the didactic part of the project and which thereby binds it together into an integrated whole the investigation is conducted in health care because this context makes apparent the full range of contingencies in life that impose limits to the rational exercise of moral agency and which thereby lock agents into diversified situations of mr however since mr is pervasive also outside of health care we believe it will benefit other branches of applied ethics as well
revisiting antibody structures and repertoires through advances in mass spectrometry and proteomics

in revamp i will create innovative structural mass spectrometry ms and proteomics techniques to generate an unprecedented molecular understanding of the diversity and structural and functional characteristics of human antibody repertoires these repertoires are highly personal and play a key role in our human immune responserecently my research has taken a novel challenging avenue with a focus on the development of cuttingedge msbased techniques to better understand antibody structure and function with these methods i have started to monitor at the protein level changes in endogenous antibody repertoires with clonal resolution including those induced by antigenspecific polyclonal responses in individuals early studies were limited to igg1 and in revamp i aim to expand the toolbox to the full antibody repertoire including all subclasses of antibodies i aim to learn how and why antibody profiles in serum and other body fluids are alike or distinct investigating structural clonal and functional differences over time and between individuals i will develop technologies to target the subrepertoires recognizing antigens from pathogens following identification by advanced topdown and bottom up de novo sequencing these antibodies will be followed up functionally as potential therapeutic leadsspecial attention will be given to igm the largest human antibody appearing first in the response to an antigen we recently made the preliminary striking observation that its structure is illdefined in textbooks and that human igm may be quite different from igm in other mammals this project will benefit from our recent advances in structural analysis by single molecule mass spectrometry mass photometry atomic force microscopy and electron microscopy revamp will overhaul our current view of the structural diversity of our human antibody repertoire and thereby elevate our understanding of how the human immune system functions
twinning to sustainable energy transition

eu is facing a pressing challenge to transition into a carbon neutral economy 2050 with an intermediate target of 55 co2 reduction emissions in comparison to 1990 greece is lagging behind in the energy transition process due to a number of reasons such ashigh share of natural gas in the electricity generation mix on a permanent basisuse of fossil fuels lignite in highdemand periodslack of industrial plans to exploit co2 capture and storage technologies as well as perspectives for co2 export in other countrieslack of geothermal energy penetration into the electricity mixgeosciences play a fundamental role in research activities tackling new energy transition themes through the use of underground resources such as the geological storage of co2 and hydrogen and geothermal energythis is the foundation of twinn2set project it will be implemented as a partnership between the institute of geoenergy of the foundation for research technology hellas el the university of stavanger no and the ifp energies nouvelles fr in the domains of 1 carbon capture and storage ccs 2 deep geothermal energy and 3 subsurface hydrogen storage the project consists of a capacity building mentoring programme in the above three areas which will be complemented by an exploratory project focusing on hydrogen storage in geological formations fostering interdisciplinary competencies at the interplay of a promising energy vector with subsurface reservoir characterisation modelling and monitoring the twinn2set project will provide a coherent network that will strengthen interactions between members of the consortium more specifically twinn2set will enable the newly established igforth to participate in the european ri process on energy transition
palaeoecological exploration of humanlinked biological invasions on madagascar

loss of biodiversity is one of the most urgent ecosystem threats and this is particularly clear on tropical islands such as madagascar effective conservation efforts should be informed by assessments of synergistic threats from deforestation biological invasions and climate change which operate on multiple timescales this proposal uses multidisciplinary biochemical analysis of bones from archaeological and paleoecological deposits on madagascar to identify endemic predators fosa and small mammals mouse lemurs and rodents that may be vulnerable to deforestation and negative interactions with exotic counterparts dogs rats and mice specifically we will apply bulk stable isotope analysis to exotic and endemic animal bone collagen from the past 3000 years to characterize dietary niches and evaluate the potential for different cases of predation and competition to obtain a deeper understanding of resource use than is possible with prevailing bulk isotope methods this project will also include the stable isotope analysis of individual amino acids present in bone collagen radiocarbon data from the same bones will substantially contribute to our knowledge of past animal translocations in the western indian ocean region we will also start to identify taxonspecific responses to past changes in resource availability by comparing stable isotope datasets from directly 14cdated bones with regional records of past climate and vegetation change these project components will pinpoint the degree to which competition has exacerbated or not the vulnerability of endemic species to human land management and climate change the research is consistent with both the current research foci of the host institution and the career interests of the applicant and the results will answer questions important to the historical sciences modern biodiversity conservation and rural communities around the study sites
hypnodelic therapy the benefits of hypnosis knowhows for psychedelic therapy

in recent years we have witnessed a renewed interest in psychedelicassisted psychotherapy pap the psychedelic compound ketamine a nmethyldaspartate glutamate receptor antagonist shows potential for the treatment of depression and addiction key psychological mechanisms underlying these effects of pap are the suggestions by the therapists and psychedelicinduced mystical experiences currently the mechanism of suggestibility in pap is receiving more attention as it is hypothesized that all psychedelics increase suggestibility a topic that so far has been studied mostly in the field of hypnosis research at a neurobiological level the predictive processing framework suggests that ketamine induces its effects by disrupting the brains predictive functioning in the context of the renaissance of psychedelic research this project proposes to leverage the practical knowhow on suggestibility from hypnosis research to investigate the intriguing interplay between suggestibility hypnotic suggestions and the psychedelic experience within the predictive processing framework our study has 4 aims 1 assess suggestibility under ketamine 2 assess hypnotic suggestions impact on the phenomenology of the psychedelic experience 3 assess if a hypnosis and ketamineinduced mystical experience leads to improved mental wellbeing and 4 validate the predictive processing framework we will conduct a crossover randomized doubleblind placebocontrolled study with a 1month followup including 36 healthy participants and 2 conditions hypnodelic ketamine hypnotic suggestions and hypnocebo placebo hypnotic suggestions we will measure suggestibility mystical experience and predictive processing through quantitative qualitative and neurophysiological analyses this groundbreaking study has interdisciplinary translational potential offering insights into therapeutic applications of hypnosis and psychedelics and paving the way for new clinical applications
breaking resistance of pathogenic bacteria by chemical dysregulation

antibiotic resistant bacteria are on the rise and could trigger the next global pandemic for some pathogens no treatment options are left leading to steadily increasing death tolls the limited scope of bacterial targets all essential for growth has favored resistance buildup whilst also being ineffective against nongrowing persister cells to overcome this threat innovative concepts are required to effectively and sustainably kill bacteria via unprecedented mechanismsmy team and i tackle this challenge by deliberately going beyond established modes of action moa to achieve this we present breakingbac a threetiered chemical strategy to dysregulate bacterial physiology first we will develop small molecule activators of crucial bacterial hydrolases to deregulate the degradation of proteins leading to devastating physiological effects although enzyme stimulation has several advantages over inhibition this concept is still in its infancy we thus showcase principles of activator discovery and demonstrate their potency against diverse pathogens second we recently discovered the complexation of free cellular heme by antibiotic isonitriles leading to a dysregulation of porphyrin biosynthesis and a corresponding induction of oxidative stress although these isonitriles are too large to access protein bound heme we will tailor their structure to additionally target hemedependent enzymes of the stress response the aim is to develop molecules bearing a dual moa a stress induction and b inhibition of stress response third we will combine our learnings to create bifunctional compounds consisting of a hyperactivating protease recruiter linked to a bait which delivers the large class of essential hemedependent enzymes for proteolysis as these protein degraders are hyperactive catalytic in nature and specific for bacterial proteases we anticipate potent antibiotic effects combined with low resistance frequencies and lack of human toxicity