Dragon09/odtu_chatbot huggingface dataset:
smart and multifunctional 3d printable proregenerative biological matrix modulating mechanotransduction as advanced therapy to treat skin chronic wounds

due to population lifestyle changes ie obesity diabetes and aging population chronic wounds cw which fail to follow the typical healing process is a major medical socioeconomic challenge current wound management is clearly insufficient and advanced therapies failed in keeping their promise of reliable skin regeneration the aim of force repair is to develop a smart and multifunctional wound dressing providing proregenerative environment and mechanical stability to treat cw thus force repair will combine stateoftheart technologies in a biological scaffold tailored to patients needs 1 antibacterial and bioadhesive bioink with antibiotics and antiinflammatory loaded nanocapsules 2 elastin like polypeptides promoting innervation and vascularization 3 wharton gel complex preventing oxidative stress and boosting key extracellular matrix proteins also the dressing activated by uv light will induce contractile force to help wound closure and activate skin regeneration a customized 3d bioprinter with a userfriendly 3d trajectory software will help to strategically placed the biological compounds to timely address and mitigate the degenerative process occurring in cw ie infection inflammation tension forces to promote skin regeneration the 3d printed dressing will be tested in relevant in vitro model with a human exudate library and testing relevant key healing steps ie reepithelization angiogenesis cell proliferation selected candidates will be tested in vivo on pig cw models and mice with bacterial infection to ensure translation to clinical practice and reach patients regulatory framework hta and a business model will be defined for a viable exploitation strategy that will decrease economic burden of wound care management and improve patients qol finally to ensure market acceptance health professional will guide the development of force repair to offer a dressing that treat efficiently cw and can be used by medical staff
towards largescale adaption and tailored implementation of evidencebased primary cancer prevention programmes in europe and beyond

the high and growing global burden of cancer urges the need for effective implementation of primary cancer prevention pcp programmes targeting modifiable risk factors however evidencebased programmes with proven effectiveness under controlled environments often fail when implemented in the real world due to ineffective adaptation and implementation strategies addressing contextspecific barriers leading to programme failures and public health inequities the pieces project will develop assess and disseminate a cancerspecific methodological implementation framework the integrated pcp implementation toolkit pcpit pcpit will provide an evidenceinformed systematic process for 1 identification selection and tailoring of pcp programmes and 2 developing evidenceinformed implementation strategies tailored to local barriers and constraints the pcpit will include a comprehensive repository of pcp programmes their theories of change and materials for systematically adapting the programmes to local needs and cultural constraintsthe project involves 16 consortium members and implementation sites from 10 countries of diverse sociocultural backgrounds and access to up to 777 million inhabitants pieces provides an ideal naturalistic laboratory to improve and study the upscaling and implementation of a wide range of primary pcp programmes targeting major risk factors tobacco alcohol low physical activity hpv infection sun exposure and diet a multisite case comparison study will be conducted to assess and optimise implementation outcomes an indepth realist evaluation using various sociological theories will be conducted to explain the processes by which the outcomes are achieved the consortium will employ a highlevel external advisory board with renowned experts facilitate continuous engagement with stakeholders and align with the eu and relevant scientific societies to ensure the future continuity of both the repository and pcpitthis action is part of the cancer mission cluster of projects on prevention and early detection
challenging ai with challenges from physics how to solve fundamental problems in physics by ai and vice versa

ai is a disruptive technology that is currently changing not only many research fields but also substantially challenges current business concepts keeping up with the everfaster progress on one hand side and the ever increasing competition from us and chinese it giants is a challenge for european industry and research institutions yet new concepts are required to keep pace this concept is to intertwine modern ai concepts with strategies from the application field a strategy where we claim that we can contribute substantially to a novel and promising research field particle physics is a formidable basis for such developments as there are no critical personal data data can be easily generated and we have a good understanding of the underlying models and the ground truth yet particle physics has challenges such as detailed questions of new physics and extremely high precision of the results we identified three main fields where this project will contribute by solving 1 highly illposed inverse problems using physics models 2 handling uncertainties rare events and give reliable error bounds and finally 3 to be able to give explanations of the machine learning results in terms of physics ontologies and models this highly challenging research agenda is tackled by 9 internationally recognized and leading researchers from both physics and computer science from 5 universities in 5 european countries all being member of the 4eu alliance of european universities over 4eu an excellent infrastructure for unique training opportunities is available to enable the research fellows to reach the ambitious goals on one hand side and to educate them in critical and innovative thinking management and social skills to prepare them optimally for leading positions in academics and industry
changes in salivary proteome and flavour perception induced by a physical activity program in overweight and obese children

overweight and obesity in children is growing worldwide at alarming rate affecting 13 of children in who european region this is a matter of concern since an overweight child has a high probability to be an obese adult in the case of children dietary patterns and lifestyle starts to be developed at this age therefore is essential promote in them healthy habits despite of the relationship between obesity and food consumption habits it is still unknown how the food preferences can determine eating patterns and finally body weight since the way food is perceived in the mouth is decisive for its mediumlong term acceptance or rejection regarding this understanding fundamental aspects of eating behaviour is crucial to develop strategies aimed at promoting healthy diets and preventing obesity in the last few years evidence emerged about the participation of salivary proteome in food oral perception as salivary proteins can interact with flavour molecules eg aroma compounds in spite of this the role of salivary proteome on oral perception is not fully understood yet moreover saliva presents plasticity and the levels of salivary proteins may differ with different metabolic or physiological conditions eg obesity changing also with food intakedietary habits as such more studies are necessary to gain understanding about how salivary proteins may impact flavour perception the purpose of this action is to elucidate how salivary proteome could contribute to flavour perception potentially affecting food choices and if this impact could vary depending on the body weight and lifestyle this focusing on children 512 years as a risk group of population for develop obesity for that the research objectives aimed to determine changes in salivary proteome and sensory responsiveness taste sensitivity and retronasal aroma induced by a 3month physical activity program in healthy weight overweight and obese children from portugal
atomicscale tailored materials for electrochemical methane activation and production of valuable chemicals

electrochemical methane activation and direct conversion to methanol is highly attractive a dream reaction that would convert a greenhouse gas into a valuable liquid fuel in a dream device onsite and powered by renewable electricity however sustainable ch activation and direct methane to methanol conversion at ambient conditions remain as great fundamental challengesmy aim with atomistic is i to develop new methods for electrochemical methane activation and partial oxidation ii to control the structure of the electrochemical interface and the catalytically active site in order to tune selectivity for the synthesis of valuable fuels and chemicals such as methanol from methane and dimethyl carbonate from methanol i will use 3 main strategiesto establish the ideal structures and electrolytes using welldefined tailored materials that enable methane activation by its direct adsorption on the electrode materialto realise advanced materials that enable the indirect electrochemical activation of methane through the generation of solution phase radicalsto tailor the active site at the atomic level for selective methane to methanol and methanol to dimethyl carbonate oxidation reactions on functional materialsi will elucidate the design principles and unveil the structurereactivityselectivity relations and the molecular mechanisms of these reactions as well as the atomicscale structure of the catalyst materials i will achieve these ambitious goals by leveraging my work combining the insight from model studies with experiments under realistic conditions to discover new materials i will combine electrochemical methods electrochemical scanning probe microscopy in situ optical spectroscopy online mass spectrometry and operando synchrotronbased xray techniques the success of atomistic will result in significant breakthroughs in the fields of chemistry and catalysis opening up new sustainable ways to produce valuable chemicals
josephson gated transistors and electronics

improving the energy efficiency of denselyintegrated electronic is an important goal towards the sustainability of modern digitallyconnected society in particular for what concerns highperformance computing datacenters an important piece of the solution is found in the contacts between metallic leads and the semiconducting channels that constitute the core of transistors the key active component in integrated circuits a significant part of increasing the energy efficiency is tied to managing the resistance that appears between metals and semiconductors the contact resistance in jogate we utilise the unique superconducting properties in hybrid superconductorsemiconductor components to uncover the mechanisms contributing to the contact resistance and thereby improve it in doing so not only we contribute to solving a major obstacle for the energy efficiency of established digital electronics but we obtain the superconducting analogues to the conventional transistors and diodes these superconducting components are unique in that they enable new avenues for superconducting circuit design resulting in opportunities in miniaturisation performance and cost of devices that find application in communication sensing and detection signal amplification and routingin jogate we wish to study superconducting transistors and diodes and to upgrade their fabrication processes to be compatible with the methods of largescale integration making it possible for europe to lead their industrial production in parallel we contribute to finding ways of improving their performance to ease practical adoption and impact in areas ranging from cryogenic electronics to demanding environments such as space applications finally to demonstrate the value of the technology and to deliver important outcomes in the shortterm we develop two prototype devices for cryogenic microwave signal management a radiofrequency switch and an integrated superconducting qubit control chip
multiscale characterisation and simulation for hydrogen embrittlement assessment development of an open knowledge platform to foster capability integration

hyway aims to develop adaptive multiscale material modelling and characterisation suites for assessing interactions between hydrogen and advanced metallic materials and demonstrate their capabilities on hydrogen storage and transport componentsadvanced materials application like hydrogen technologies is essential for achieving the eu carbon neutrality goal however deploying hydrogen technologies needs a tremendous effort to complete the infrastructure requiring efficient material assessment suites enabling industries to be more effective in developing and working with materials furthermore since hydrogen is stored and transported in several forms the material assessment suites must be flexible and capable of revealing hydrogenmaterial interactions in various conditionsthe hyway suites contain 3 key modules physical realm virtual world and data and knowledge management platform dkmp the physical realm will advance experimental capabilities to reveal hydrogenmaterial interactions by compiling characterisation methodologies across length scales the virtual world will develop a multiscale and multiphysics materials modelling framework for disclosing how hydrogen alters changes in advanced materials under various service conditions the physical realm and the virtual world are interdependent and complement each other through the data exchange between modules we will establish the dkmp to facilitate the data exchange and merge material research disciplineshyway will ensure the productive allocation of investments required in constructing the hydrogen infrastructure we will strengthen european capability in steering green transition with digital technologies and future emerging enabling technologies and ensure an open strategic autonomy by supporting the transformation of the eu energy mix to be dominated by hydrogen the consortium comprises renowned experts from academia and industries across the eu and will support ukraine on its european path
robotics and artificial intelligence living labs improving operations in pv scenarios

talos will develop and demonstrate worldclass robotics solutions for different photovoltaic pv energy operating scenarios landbased floating and agripv promoting innovation in both the energy and agriculture sectors talos will demonstrate the added value of robotics and their potential in reducing greenhouse gas ghg emissions 450tonyear minimising wasted resources up to 35 water saved lowering operation and maintenance om costs up to 5 and optimising humanrobot and robotrobot collaboration to reduce humans exposure to risky environments dangerous dull or dirty tasks will be performed autonomously by the talos solutions such as monitoring inspection cleaning and vegetation management where robust robotics solutions will be developed for all pv scenarios and demonstrated to show increasing pv plant performance ratio up to 10 reducing the risk exposure of om workers by 90 or the human burden of monitoring crops by 90 in the demonstration scenarios allowing feasible inspection periods to be 247 a multirobot platform and recommendation system will demonstrate 30 robotrobot interactions 30 inspections and humanintheloop features and training sessions for end users and workers requirements will be cocreated with relevant stakeholders and refined for the technology partners within the consortium as well as for the 913 robotics startups that will be granted the cascade funding and demonstrated in the test bed scenarios set up by the project
ontological bridges for climate change mitigation in maasailand

ontological bridgebuilding for climate change mitigation in maasailand obccmm is a multidisciplinary project that builds bridges across clashing climate ontologies in maasailand in tanzania this holistic project integrates indigenous knowledge and climate science that is negotiated through ecotheological frameworks the collaboratively developed core values and learning outcomes are worked into curricula components four target research groups this project leverages existing educational and societal systems of the church with trusted local leaders for educating and equipping with the best practices of climate change mitigation in maasailandthis project grows out of recent research that demonstrates a cognitive dissonance clash between the climate ontologies within the scientific messaging and the traditional maasai worldview de wit 2020 thus the tanzanian governmental efforts in climate change prevention education are not effective among maasai a very traditional people group numbering around two million people in mostly northern tanzania and southern kenya east africa de wit 2018 however as a result of the hivaids pandemic there is an established basic model of the church providing a strategic role in bridging the cognitive dissonance chasm between the science and a skeptical people group resulting in effective outcomes watt et al 2009 this project expands the current research builds upon the previous churchbased pedagogy models integrates indigenous knowledge collaboratively curates core values and learning outcomes champions women as the core of the societal structures and develops innovative pedagogical dissemination with robust analysis of results in order to measure and determine best practices of climate change mitigation in maasailandas the local church made a difference in the health of the people regarding hivaids the local church can make a difference in the health of the environment
unravelling interactions between fermentable carbohydrates and the gut microbiota in patients with ibs

what can i eat this is the question that patients with irritable bowel syndrome ibs ask their general practitioner diet is the first line of treatment for ibs and is based on restricting foods containing a group of sugars fermentable oligo di monosaccharides and polyol or fodmaps which are not fully absorbed by the host and fermented by the gut microbiota although effective this treatment is not sustainable in the long term as the diet requires limiting beneficial foods such as vegetables and fruits to date due to a lack of specific trials our understanding of which and how specific fodmaps contribute to ibs symptoms has yet to be uncoveredbased on 1 preliminary results showing a patientspecific response to purified fodmaps in ibs patients 2 the central role of the gut microbiota in fodmap digestion and 3 the interindividual variation of the gut microbiota between individuals and ibs patients i hypothesise that specific fodmaps cause symptoms in ibs patients through individualised microbiome activity by combining my bioinformatics skills and microbiome background with wetlab microbiology expertise of the host group i aim to identify bacterial species and metabolites causing the development of symptoms firstly i will analyse samples and clinical data from a trial conducted in the host lab in which patients were exposed to six purified fodmaps to identify microbiome changes in those experiencing symptoms next i will test the interaction between fodmaps and the identified microbes with highthroughput invitro fermentation monitoring dynamic shifts in the gut microbial ecosystem and metabolic activity upon fodmap exposure finally i will determine if baseline microbiome or metabolite profiles can predict an individuals tolerance to specific fodmapsthe outcomes of my research project will pave the way for innovative effective noninvasive and personalised therapeutic approaches for a disorder affecting 10 of europeans
accelerating the validation of predictive liquid biomarkers for frontotemporal dementia diagnosis and subclassification

frontotemporal dementia ftd has a debilitating effect on patients and their caregivers and leads to substantial economic costs 1530 of patients have familial ftd caused by known pathogenetic mutations for the other 7085 of patients termed sporadic ftd diagnosis is slow 36 years with frequent misdiagnosis due to clinical genetic and molecular heterogeneity thus there is great need for biomarkers for early diagnosis of sporadic ftd and its pathological subtypes in predictftd we will validate a set of biomarkers and create a diagnostic tool for early diagnosis of familial and sporadic ftd which will facilitate tailored support and symptomatic treatments and care we will apply several new approaches to achieve this 1 we combine 11 geographically diverse cohorts of sporadic and familial ftd with retrospective and prospective longitudinal liquid biopsy samples and extensive clinical and behavioural data 2 we are the first to use multimodal clinical and liquid biomarker data to train an aialgorithm as a diagnostic tool for quick and early clinical ftd diagnosis and 3 we implement a novel robust twostage strategy for biomarker and ai algorithm validation where phase i validates biomarkers and algorithms on a cohort of genetic and autopsied cases and phase ii assesses biomarker value for diagnosis of sporadic ftd and atrisk presymptomatic mutation carriers we will apply this twostage validation strategy to address three critical clinical challenges i to distinguish sporadic ftd from non neurodegenerative disorders that show significant clinicalsymptomatic overlap ii to robustly detect ftd pathological subtypes in sporadic ftd and iii presymptomatic identification of ftd onset thus predictftd will transform ftd diagnosis offering potential for early disease confirmation guiding treatment decisions facilitating patient recruitment for clinical trials guidance of patients and caregivers and enabling preventive measures
saortrack wireless position tracking in the or

magnetic tracking technology is the goldstandard for in vivo navigation where lineofsight is not available magnetic trackingreduces dependence on radiation imaging and provides highly accurate tracking of instruments tools and cameras inside the patienthowever existing commercial and research solutions are wired highaccuracy wireless tracking can transform existing clinical applications of magnetic tracking such as electrophysiology ep mappingof the beating heart by dramatically reducing wire clutter in the or and simplifying the clinical workflow more importantly wireless tracking can open up new clinical applications where highaccuracy position navigation are not feasible to date such as in capsule endoscopy existing capsules provide video feed to the clinical team without localisation to the patients anatomy our wireless position navigation design can seamlessly integrate with existing technology solutions to provide highly accurate localisation of abnormalities within the colon resulting in more precise and faster diagnosisthis project builds on groundbreaking innovations from the erc deep field project to demonstrate proofofconcept preclinical validation for our wireless magnetic navigation design in highvalue existing applications in cardiology such as ep mapping as well as demonstrating feasibility of highaccuracy position navigation in capsule endoscopy for the first time