Dragon09/odtu_chatbot huggingface dataset:
novel bioinspired energy harvesting and storage allinone platform for implantable devices based on peptide nanotechnology

over the past decades implantable biomedical systems have greatly advanced offering previously unavailable therapeutic options for millions of patients worldwide such applications most commonly utilize conventional lithiumion batteries as the energy source however while readily providing adequate energetic performance lithiumion batteries are inflexible rigid may contain toxic substances and require periodic replacement surgeries due to their limited capacity posing both health risks and an economical burden here aiming to address these issues we will develop pepzopower a biocompatible energy harvesting and storage device designed for biomedical applications energy harvesting will be facilitated by highlyefficient piezoelectric peptidebased assemblies allowing to harvest mechanical energy from the human body and convert it into electric energy the harvested mechanical energy will be stored by a biocompatible peptidebased supercapacitor thus giving rise to an autonomous miniaturized controllable and biocompatible power device with adequate performance and mechanical properties this ambitious goal will be achieved by utilizing our patentprotected piezoelectric and energy storage peptidebased supramolecular structures to be incorporated into an integrated device the performance of each layer will be optimized and the integrated pepzopower device will be validated to verify efficient incorporation of the two components we envision the breakthrough pepzopower technology to serve as the basis for the next leap toward biocompatible soft miniaturized lightweight and morphologicallycontrollable implantable devices this will pave the way towards postproject commercial exploitation of the pepzopower system which will be further developed by a spinoff company to be integrated into implantable devices ranging from cardiac defibrillators to spinal cords stimulators opening a huge market opportunity for this radically new technology
targeted nanohorns for lithium neutron capture therapy

cancer accounted for nearly 10 million deaths in 2020 half of all cancer patients are treated with radiation therapy either alone or combined with other therapeutic modalities mainly surgery and chemotherapy one of the first concerns related to radiotherapy is the toxicity of healthy organs and tissues close to the tumour it is wellknown that radiation therapy not only kills cancerous cells that divide but also affects to the cells in division in healthy tissue neutron capture therapy nct is a form of radiotherapy that exploits the potential of some specific isotopes for cancer treatment the nuclear reaction that takes place when some isotopes are irradiated with neutrons produces lethal particles with path lengths that can limit the destructive effects to a single cell thus conferring high therapeutic precision to this form of radiotherapy for this therapy to be successful enough neutron active atoms must be delivered to the tumour site so a lethal capture reaction can take place however current benchmark pharmacologic agents are limited in their performance due to the low concentration of active species delivered in the tumour sites tarlit goes beyond the stateoftheart and presents an innovative approach that consists on the design of nanoparticles as carriers of enriched lithium compounds the possibility to deliver lithium nuclides into cancer cells and the fact that nuclear reactions of lithium resultant from neutron irradiation produce higher energetic particles that the current state of the art can significantly improve the efficiency of nct in the eradication of cancer cells and tumours
innovative toolbox empowering effective cap governance towards eu ambitions

the new delivery model established in regulation eu 21152021 entails significant changes to common agricultural policy cap governance with the introduction of strategic plans and new monitoring review and evaluation requirements the cap is expected to contribute significantly to the green deals ambitions securing the achievement of sustainability and resilience goals for the eus agrifood systems innovative governance models are essential to enable resultbased policymaking to deliver the best policy pathways to facilitate the green transition tools4cap will 1 support the implementation of national strategic plans 20232027 and 2 lay the foundations for sound preparation of post2027 strategic plans accordingly tools4cap establishes a flexible and participatory coordination support action designed to boost learning exchange processes and adoption of innovative solutions and good practices for the design monitoring and evaluation of cap strategic plans tools4caps methods and tools will cover three key areas 1 quantitative modelling tools for exante and expost evaluations 2 participatory and multigovernance decision tools and 3 novel data and monitoring solutions the project will deliver a comprehensive inventory of methods and tools used in the 27 member states methodological guidelines on innovative solutions and a handbook of good practices results will be integrated in a capacity building toolkit designed to enhance sciencepolicy interfaces tools4cap utilises a stakeholder engagement platform to boost bottomup adaptation of innovative methods and tools it will establish a replication lab to demonstrate their use in 10 member states and to promote their uptake across the eu27 the project will also set up a capacity building hub to help endusers ministries management authorities paying agencies other stakeholders reinforce their capacity to use innovative tools including models used by the european commission
building the first automated causal discovery platform

causal discovery is desperately needed in both science and the industry but it is largely inaccessible to nonexperts autocd proposes to create the first automated causal discovery software engine and explore its commercial exploitation autocd will largely boost the productivity of experts as well as allow the application of causal discovery with minimal expertise it will provide functionalities such as a induction of causal models and causal relations from data by automatically tuning the algorithmic causal discovery choices and their hyperparameters b inferences regarding the strength of causal effects and exploration of whatif scenarios of possible interventions such automation has only become recently possible due to research performed of the origin erc named causalpath we will work with two industrial partners namely gnosis data analysis and huawei to validate autocd on real data and problems gnosis commercializes the jadbio product which is a saas automl platform with obvious synergies to autocd it has an expressed interest in autocd for a potential licensing deal see letter of intent autocd parallels the development of automated machine learning automl libraries and platforms that is growing to a 14bil industry the project will create an mvp at trl 5 and a business plan to commercialize the product the research team 2 profs 1 phd student 1 scientific programmer have extensive collective experience not only inventing and designing novel causal discovery algorithms in addition the pi is also the cofounder of gnosis with extensive experience in creating deep tech automl products and commercializing them he will devote 70 of his research time to the project
boosting efficiency and stability of tinlead perovskite photovoltaics with chemically smart device architectures

perovskite photovoltaics offer a lowcost highefficiency solution to speed up the transition to netzero emissions in particular tinlead perovskite solar cells have ideal optical properties for peak performance however their largescale use is hampered by stability issues at perovskite surfaces ie oxidation vulnerable defects and chemical mismatch with ordinary charge transport layers in solar cells selfassembled monolayers sams are alternative transport layers that allow the manipulation of critical interface regions yet their use in tinlead perovskite photovoltaics remains in its infancy careful choice of sam functional groups molecular structure and redox chemistry are key to tackle perovskite limitationssamper will develop ultrastable and highly efficient tinlead perovskite solar cells by designing sam device architectures with interfacespecific smart functionality defectpassivating perovskitehealing and oxidant scavenging sam moieties will afford the targeted properties as will be demonstrated via structural chemical and electrical interface analysis top sambased devices will be tested outdoors to demonstrate their excellent durability and efficiency comprising the first example of tinlead perovskite solar cell testing under realworld conditions and paving the way towards their commercial deploymentsamper contributes towards clean energy in alignment with european green deal decarbonisation targets the project will further the researchers excellence and career prospects via training on cuttingedge multidisciplinary research knowledge transfer with the supervisor will foster the researchers scientific independence via key management skills the secondment for outdoor tests will facilitate international synergies project outputs and datasets will adhere to fair principles aiding the benchmarking of the technologies herein various activities will disseminate these results and foster stem vocations among local youth
catalysing investment into catalan bioeconomy via onestopshop accelerator

catalonia offers huge potential to become a showcase for bioeconomy innovation and deployment in europe the region is a hub of hightech manufacturing research and industry vehicles chemical health has extensive forests 60 coverage agricultural production and fisheries and it is backed by strong institutional support for the bioeconomy with the catalan bioeconomy strategy launched in september 2021however circular bioeconomy projects involve a wide range of stakeholders complex business models and demand strong technical and legal knowledge from developers investors regulators and local planning authorities for these reasons many viable bioeconomy projects are overlooked and are unable to raise sufficient investmentbioboost aims to accelerate the growth of the bioeconomy in catalonia by delivering project development assistance pda services that address the specific and systematic barriers preventing bioeconomy projects from reaching the investment stage pda services will be delivered via a onestopshop office in barcelona the accelerator the needs of bioeconomy projects will be assessed project development plans developed and a package of pda services offered the office will also work together with the investment community and public institutions to prepare these stakeholders for investment and construction phases pda services will be delivered by a powerful consortium of sector specialist that bring together all the core components of successful project development 1 facilitation and coordination symbiosis
regular and exotic behavior in hamiltonian and lowdimensional dynamical systems

rexhalodyn aims at understanding some of the regular and exotic features of hamiltonian systems circle maps and generalized interval exchange transformations or giets hamiltonians provide a powerful description of classical mechanics phenomena circle maps and giets are archetypal examples that illustrate fundamental concepts and phenomena within dynamical systems moreover the latter two offer simplified models that capture essential features of more complex systems eg they appear naturally as poincar maps of locally hamiltonian flows on compact surfaces and thus are closely related to hamiltonians in this context within this framework the words regular and exotic do not have a precise mathematical meaning however we use them here to stand for features in each system that are either wellbehaved regular such as the existence of stable quasiperiodic motions in hamiltonian and rigidity phenomena in circle maps and giets and for features that are illbehaved exotic such as sensitive dependence to initial conditions in hamiltonians or existence of singular invariant measures in circle maps and giets understanding these complementary features deepens our understanding of the systems their properties and the underlying mathematical structures that give rise to a rich spectrum of behaviorsthe main objectives of this project areprove the existence of lowerdimensional invariant tori associated with a resonant torus with any number of resonances for general classes eg convex of nearintegrable hamiltoniansobtain precise estimates for the hausdorff dimension of the unique invariant probability measure of multicritical circle maps with irrational rotation number of bounded typeobtain rigidity results for multicritical circle maps with irrational rotation numberthe research is planned for two years and takes as a basis many of the results and methods developed by the applicant in his previous works
rna and nanotechnology enable wider accessibility to stem cell transplantation

every year more than 50 000 patients receive blood stem cell transplantation as a curative treatment for diseases such as leukemia immune deficiencies and sickle cell anemia for a successful transplantation a matching donor who is willing to donate blood stem cells needs to be found worldwide around 30 patients in need of a transplantation cannot find a suitable donor umbilical cord blood ucb is an easily obtainable alternative source of blood stem cells but unfortunately most ucb units do not contain enough stem cells for a successful transplantation which is why ucb is currently only rarely used in the clinic within the erc project unexpected we have identified several small rna biomolecules that can be used to expand engraftable blood stem cells efficiently however it is difficult to safely deliver molecules to blood stem cells and currently used methods are highly toxic we recently applied cutting edge nanotechnology to solve this longstanding problem in stem cell biology we established nanostraws as an efficient and gentle alternative delivery method with which both cell function and viability are fully maintained our method that allows efficient nontoxic delivery of blood stem cellexpanding rnas will allow us to greatly increase the number of ucb units that can be used for transplantations our approach could provide a lifesaving treatment option for the thousands of patients yearly with malignant or inherited diseases that currently are ineligible for a stem cell transplantation procedure
adaptive fire testing a new foundation stone for fire safety

the current fire safety paradigm is based on a set of standardized tests which have been developed as part of a prescriptive design framework and do not provide indepth understanding of construction products fire performance the resulting incomplete fire performance characterization hampers the much needed innovation in the built environment the current fire safety paradigm also places tremendous emphasis on the expertise of controlling bodies ahj making them responsible both for the specification of detailed prescriptive rules and for the acceptance of performance based designs this is unsustainable in the face of innovationafiretest strives to induce a paradigm shift in fire safety science and engineering fsse the core of afiretest is the development of adaptive fire testing whereby optimum fire tests are determined from the infinite number of possible test specifications through the maximum expected net information gain value of information voi this will be developed using modern glazing and load bearing glass as innovative case study resulting in breakthroughs in fire performance understanding secondly a framework for advanced grey surrogate modelling will be developed combining the pattern identification strengths of machine learning with fundamental fsse constraints this will introduce a powerful new tool to fsse and enable the voi optimization a grey modelling approach will also be developed for quasiinstantaneous building specific risk evaluations allowing a new approach to the ahj acceptance of fire designs the future operationalization of the new framework for fire design acceptance will require large followup investments thus stakeholder buyin is crucial therefore afiretest will develop a methodology for the costbenefit evaluation of fire safety frameworks for the first time fire safety approaches will be evaluated from the perspective of law and economics laying the groundwork for an entirely new field of study
european action for the diagnosis of early nonclinical type 1 diabetes for disease interception

edent1fi is a unique and timely project building and operationalising an open platform for general population screening of childrenadolescents for type 1 diabetes t1d throughout europe the case is compelling t1d is a common chronic disease affecting 1 in 300 children or adolescents decades of european research have signposted the stepwise nature of t1d development and generated tools for early diagnosis monitoring and disease modification edent1fi now positions europe as the leader in early interception of t1d our goals are to identify individuals at earlier preclinical stages dramatically reducing clinical severity at t1d diagnosis and providing the opportunity for interventions with disease modifying therapies to delay or prevent clinical t1d spurred by the success of our collaborations in model european childhood screening activities and clinical networks in gppad and innodia edent1fi will establish harmonised islet autoantibody surveillance programmes to screen 200000 childrenadolescents across europe assess the psychosocial medical and economic impact of screening in diverse european health systemspopulations including underserved families use state of the art metabolic sensors and biomarkers to optimise monitoring schedules for earlystage preclinical t1d aligned to maximising compliance and identifying disease progression strata design smart trials to expedite evaluation of disease modifying therapies and inform and educate the public healthcare professionals and regulatory authorities of the new paradigms in t1d diagnosis and care to achieve this edent1fi assembles academic clinical and industry expertise in screening clinical care biomarkers machine learning population outreach ethics regulatory affairs and policy to accelerate evidencebased early t1d screening into regular healthcare in europe the success of these activities will promote early diagnosis and prevention pathways for other chronic childhood diseases
a spinwave ising machine

the swim project will tackle a critical challenge for the emerging field of ising machines ims the development of miniaturized lowpower and lowcost ims with high computational power commercial feasibility and speed beyond classical vonneuman and cmosbased solutions swim will achieve this through exploiting exceptionally slow propagating spinwaves and using offtheshelf powerefficient microwave electronic components and circuits in an entirely novel architecture of yigfilmbased ising machines im with potential performance many orders of magnitude beyond the stateoftheart the projects objectives are to explore the possibilities of using spinwaves and microwave signals to construct multiphysical timemultiplexed ims and study and determine the spinwave phenomena and electronic design techniques needed to improve targeted parameters power consumption ising spin capacity physical size and speed performance the objectives will be achieved through a multidisciplinary approach involving classical and modern methods theoretical magnetostatic description of propagating spinwaves micromagnetic simulation methods and electronic circuit design theory will be used for the swim design brillouin light scattering spectroscopy and microwave measurement techniques will be used for the analysis of the results and further improvement
powering wearable devices by human heat with highly efficient flexible bioinspired generators

selfpowered wearable electronic devices will be key technologies for future portable electronic systems in the internet of everything ioe however their potential is limited because of their need for batteries which are bulky heavy lack the flexibility to be adapted to the human body and require frequent recharging or replacement in that context flexible thermoelectric generators tegs that capture the bodys heat and convert it into electrical energy are a potentially promising and sustainable alternative nevertheless commercial tegs are produced on rigid substrates so they cannot adapt to the human body the current solution proposed is to produce them on flexible polymeric substrates which unfortunately have low thermal conductivity the active powergenerating layer must be very thick and it is not efficient enough additional problems are no good electrical and thermal contacts and the nonavailability of commercial low input power dcdc converters powerbyu seeks to merge four scientifically disruptive concepts to achieve the technological breakthrough of getting flexible and efficient enough flexible tegs 1 generate not yet existing bioinspired nanoengineered flexible polymeric substrates with very high thermal conductivities in the outofplane direction 2 generate a bioinspired patterning of the polymer surface to drive the thermal flow from perpendicular to parallel to the energy generation layer this is important because then the important length to avoid thermalization is not thickness but lateral size 3 produce worldrecord efficient quasi2d thermoelectric layers generated by a unique deposition tool and 4 new solutions to the commercial dcdc converter by assembling all the previous concepts i expect a novel high efficiency flexible teg able to generate tens mwcm2 enough to selfpowering wearable devices additional fields of application could be thermal management in buildings textiles packaging
valorising and balancing the ecosystem service benefits offered by legumes and legumebased cropped systems

the legumes will ensure 1 the uptake of best practices in agrobiodiverse legumebased cropped systems 2 the uptake of methodologies and tools to quantify and balance the environmental and economic ecosystem service es benefits provided by legumes 3 that the es benefits and cost offered by legumes are quantified across scales from field farm regional national and global levels and 4 es will be assessed to identify those conditions which are able to meet the eu targets to decrease agrichemical inputs and losses combat climate change reverse biodiversity loss and ensure the best nutritional provisioning to achieve this legumes offers a multidisciplinary consortium comprising 22 partners from 12 eu and third countries uk ch and including 7 academic institutions 6 research and technology organizations 5 smes or microsmes 2 nongovernmental organisations and 2 large commercial companies the individuals comprising legumes offer skills which include agriculturalcrop and environment es monitoring life cycle assessment economic and socioeconomicmodelling socialscience euagricultural and environmental policy and law plus decision support systems the legumes research and innovation strategy centres on the use of a multiactor actionresearch approach that is where legumefacing stakeholders and especially producers though all value chains actors can operate collaborate and reflect critically on the measured es benefits and costs of legumebased cropped systems including legumes use in marginal lands so that an optimal balance of es can be achieved with success locally and globally to help achieve this legumes also centres activities on a suite of 25 innovative legumebased pilot studies which use a wide range of legume species and types plus different cropping approaches and linked value chains spanning the pedoclimatic regions of europe