Dragon09/odtu_chatbot huggingface dataset:
hyperconnected simulation ecosystem supporting probabilistic design and predictive manufacturing of next generation aircraft structures

caelestis will develop an endtoend interoperable simulation ecosystem ise that will perform multidirectional dataflow across the aircraft value chain linking product design and distributed engineering teams cadcae tools to accelerate the design and engineering optimization of disruptive aircraft and engine configurations ensuring their manufacturability from the design conceptualization caelestis ecosystem will be developed to integrate interoperate and autonomously execute simulation workflows involving a variety of stateoftheart simulation tools to support the multidisciplinary design optimisation as well as uncertainty quantification and propagation across the design and manufacturing chain the ecosystem will be boosted by hpc infrastructures to massively execute predictions and deliver optimized design and engineering outputs at realistictime scales in this regard highfidelity modelbased digital twins with unprecedented level of detail and covering several production stages and manufacturing deviations will be developed and interconnected those will be linked to machine learning tools adapted to hpc simulation outputs to improve detection of manufacturing flaws based on a probabilistic approach to quantify uncertainties and their propagation and influence on structural integrity as well as identify design for manufacturing interdependencies to provide optimized product topologies from manufacturing point of view hpc simulations will be made available at manufacturing shopfloor as reduced order models in online monitoring edge computing devices to support i product performance prediction based on detected defects on real time and ii informed corrective actions to minimize and compensate their effect overall caelestis ise will contribute to generate optimized and reliable aircraft design configurations widen the design space and optimize the manufacturing process window and improve production efficiency and inline quality assurance
nutrition place and climate nietzsches environmental ethics

the debate on nietzsche and environmental ethics was started by max o hallman in 1991 despite underlining nietzsches affinities to ecological thought he maintained that we cannot infer any environmental ethics from nietzsches philosophy most scholars agree with hallman by contrast the main objective of this project is to demonstrate for the first time that nietzsches thought provides a coherent environmental ethics based on the notion of metabolism this environmental ethics may pave the way for a new paradigm of sustainability at the intersection between diverse disciplines such as philosophy and sociology which can mitigate the impact of the anthropocene in his intellectual autobiography ecce homo 1888 nietzsche affirms that the issues of nutrition place and climate must be placed at the centre of philosophy for nietzsche spirit itself is just a type of metabolism and i aim to demonstrate that he considered humans parts of natures metabolism with this view nietzsche i shall argue responded to the physiology debate of his time in the light of this i will address the following questions what are the most recent contributions in the field of environmental ethics what are the main positions on metabolism within the 19thcentury physiology debate what are nietzsches stances on nutrition how does nietzsche elaborate an ethics of place and how does nietzsche respond to the physiology debate of his time i will analyse nietzsches works chronologically in order to show the development of nietzsches ecological thinking i will use martin muslows method of the konstellationsforschung which examines the perspectives of the various thinkers who addressed the same problem in the same historical period regardless of whether they were familiar with similar ideas of other philosophers or not following this method i will reconstruct the debate on metabolism at nietzsches time and put it into dialogue with nietzsches works
towards the next generation of high performance liion battery cells

the liion battery lib market is now entering a period where energy density improvements and cost reductions are levelling off for the current generation 3a to continue with this trend while keeping pace with the increasing industry demands for cost reduction userfriendliness of electric vehicles and safety breakthrough innovations at material level and cell design are needed within this context nextcell overarching goal is to provide a new 3b lib cell generation for both high capacity and high voltage applications developing and validating a groundbreaking gellified cell concept the project workplan revolves around a three dimensionbased methodology i prototyping the gellified cell concept up to trl6 20ah ii modelling the gellified cell concept and iii evaluation of technical safety sustainability and costs improvements nextcells approach will not only provide europe with cutting edge 3b cells but will also tackle three key parameters hindering a greater market penetration of libs technology i costs optimising its manufacturing processes reducing capital and operating costs of future gigafactories by avoiding evaporation of solvents and the electrolytefilling step ii safety producing intrinsically safe cells avoiding the presence of low boiling point components in cell components iii sustainability reducing energy consumption by 50 against soa and avoiding the use of toxic organic solvents nmp the project is led by the electric vehicle industry from the project coordination by fev leading vehicle and powertrain international service provider to key industry manufacturers along the value chain such as solvay polymer binders and separators abee cathode production varta lib manufacturer or crf research centre for the fiat chrysler automobiles group thus nextcell has a solid determination towards fast and successful commercialisation of the novel cell design and its new components after the project
adaptation to climate change in the rhizosphere across the millennia

starting from a unique collection of paleoenvironmental samples frozen arctic soils and sediments already at awi and their corresponding ancient dna adna metagenomes that stretch back up to a million years we will retrieve information on how rhizosphere biodiversity and functionality responded to climate changes and extreme events preliminary metagenomic data from the collection suggests it is a gold mine of archaic dna that represents a timeline of adaptions to climate change in the rhizosphere by reconstructing and analyzing these ancient metagenomes and correlating with available historical climatic change data we will identify molecular adaptions that impart climate tolerance specifically resistance to increased temperature and drought this will be used to i produce and test engineered rootcolonizing bacteria pseudomonas fluorescens and pseudomonas chlororaphis that will improve climate tolerance of plants production of humidifying polysaccharides around the root facilitating the ability to grow on marginal agricultural land mal ii inform ancestral reconstruction of thermostable andor cold tolerant enzymes for industrial application and iii produce engineered pseudomonas putida strains tailored for bioproduction for the latter application we will select genes that encode biomolecules relevant for climatetolerant phenotypes humidifying polysaccharides and the biosurfactant betaines the production of these molecules using biotechnology will be targeted in the project and their application in selected industrial products verified target enduser applications will include polysaccharides and betaines for the development of 3d printed organonchip and drug delivery systems as well as the formulation of metalworking fluids lubricants and industrial cleaning products
validation of a new drug target in nonalcoholic steatohepatitis

this research focuses on the increasing prevalence of metabolic liver disease specifically nonalcoholic steatohepatitis nash which is driven by obesity diabetes and its related causal connections nash is a significant medical challenge with no approved treatments causing a substantial economic burden the project aims to investigate the role of oxidative stress in nash development and progression by targeting the map kinases p38 and jnk which drive the inflammatory and fibrotic aspects of nash our research could lead to new treatment approaches
motivic integral padic cohomologies

this project aims to study padic cohomologies of varieties using tools from motivic homotopy theory voevodskys theory of motives has played a crucial role in solving deep mathematical conjectures however motives intrinsically lack a theory of tale padic realizations in this project we will use logarithmic geometry tools to generalize the motives category and overpass this problem more specific goals are related todevelop a theory of integral logtale motives and realizations prove a general comparison between the logtale padic realizations and tame cohomologiesdevelop a theory of motives over log points with an integral hyodokato realizationsolve structural problems in the theory of motives of logarithmic schemesmipac is an innovative project in motivic homotopy theory built to impact several areas within motivic and arithmetic geometry the project will be completed at the university of milan in a leading multidisciplinary and collaborative environment i will bring extensive experience in log motives and some unique expertise on nona1invariant cohomology theories i will benefit of the experience and knowledge of the groups of algebra and geometry in padic cohomologies and motivic homotopy theory this will facilitate the research in the group and the transfer of knowledge and expand my experience and intuition transferable skills and professional networks carrying out mipac within a marie skodowskacurie fellowship will enhance the development of my career as a complete and independent leading researcher with a reinforced position within arithmetic and motivic geometry the leading position of the groups and the department will ensure a great network of international researchers with an impact to the disseminations of the ideas of mipac
underlying models for the european digital twin ocean editomodel lab

editomodel lab will prepare the next generation of ocean models complementary to copernicus marine service to be integrated into the eu public infrastructure of the european digital twin ocean edito that will ensure access to required input and validation data from emodnet eurogoos ecmwf copernicus services and sentinels satellite observations and to highperformance and distributed computing facilities from eurohpc for hpc and other cloud computing resources and that will be consolidated under developments of destination earth destinethe objective is to make ocean knowledge available to citizens entrepreneurs policymakers decisionmakers and scientific experts alike thus enabling them to become partners in knowledge generation explore desirable futures and develop ocean management scenarios and assemble their own twins with the overarching goal of ensuring a safe healthy and productive ocean as an interactive and user driven initiative editomodel lab will deliver a virtual ocean model lab voml including 1 a core model suite including global highresolution models and coastal configurations 2 downstream user toolkits and 3 a developers toolkit for a sustainable oceanthe voml will be an interactive and codevelopment environment to operate models edito core model suite will be based on modelling and simulation software artificial intelligence ai algorithms and specialised tools to form a new service capacity for accessing manipulating analysing and understanding marine information intermediate and downstream stakeholders will find digital tools data and information for focus applications fa that refer to the mission ocean lighthouses mols and the sustainable blue economy including whatif scenarios to find solutions to natural and maninduced hazardseditomodel lab will be delivered in 36 months by a consortium of 14 authoritative partners covering ocean knowledge modelling and technological expertise
pension reforms and healthy ageing in italy and europe quasinatural experimental analysis of linked health and pension datasets

the covid19 pandemic has forced many european countries to spend money that they do not have this is creating unprecedented levels of debt and will inevitably lead to pressure for retrenchment in social welfare with pensions seen as a key target while some nations will seek to protect pensions others will not how will these pension reforms impact on healthy ageing will such reforms pension save money or perversely pass costs onto healthcare and other welfare systems we propose an ambitious research programme to inform these critical questions our proposed research combines analysis of the surveys on health retirement and ageing in europe share in 19 eu countries with specific quasinatural experiment studies of pension reforms increasing pensionable ages uk 1995 pension act and italy 2011 fornero reform and reducing pension payments netherlands 2013 pension reductions and greece katrougas law 2016 additionally the project will create innovative administrativerecord linkages in italian pension and health system data to quantify occupationspecific mortalities and unequal survival times overall it builds on the pis strong trackrecord in evaluating health impacts of austerity and natural experiment research designs the anticipated findings will test critical ideas about a healthpromoting pension system and about which occupational groups may merit additional compensation due to lower survival times it will help inform critical policy debates by revealing the hidden and unanticipated health consequences of pension reforms and associated inequalities
sponge diseases under climate change a multiomics approach to the holobionts molecular functions

the mediterranean sea is a climatechange hotspot which is often considered a miniature model of the world ocean therefore it may allow foreseeing some of the expected global effects of climate change sponges hold numerous key roles in benthic ecosystems functioning in the mediterranean sea they create complex habitats serving as spawning and nursery grounds for fish and invertebrates and their filterfeeding activity affects entire food webs and benthopelagic couplings these keystone organisms are frequently suffering disease outbreaks and mass mortalities that are mostly triggered by marine heatwaves sponges are wellknown holobionts that host complex symbiotic microbial communitieswhile some members of these communities offer adaptive advantages others may contribute to disease outbreaks when environmental conditions changethis interdisciplinary research aims to discover the complex mechanism of thermalstressrelated necrosis and mortality of the sponge holobiont by studying the effect of heatwaves on the mediterranean bath sponge spongia officinalis through a holistic approach that includes morphological transcriptomic metagenomic and metabolomic responses of the holobiont to study causative as well as correlative disease events the experimental setting of this project will combine in situ sampling of healthy and diseased individuals as well as exposure of individuals kept in aquaria to simulated marine heatwaves these will provide the first insight not only to the change in the microbial community composition but alsoto the functionality of its members during thermal stress it is imperative to understand the mechanism of disease prevalence and mortality and to likely suggest ways to mitigate this phenomenon the expected increasing frequency of marine heatwaves can cause irreversible damage to entire ecosystems that rely on sessile invertebrates such as sponges and thus to numerous ecosystem services provided to human societies
vault

techniques and methods of illegally gaining access to digital information have reached new heights and are not expected to slow down so far existing solutions showed they are not able to keep data secure companies and other organisations are struggling with this issue and fail to keep up with legal regulations and face potential backlash from the public with our breakthrough solution we will tackle all existing issues concerning data protection these include encryption performance scalability and key storage issues our unique endtoend encryption technology is based on proprietary code and encryption algorithm patent pending the technology has been successfully tested on over 500 million data sets in multiuser environments as well as against existing encryption techniques for the first time there will be a tailored endtoend encryption solution for every type of organisation without any compromises in performance scalability and data security
infectious disease decisionsupport tools and alert systems to build climate resilience to emerging health threats

climate change is one of several drivers of recurrent outbreaks and geographical range expansion of zoonotic infectious diseases in europe policy and decisionmakers need tailored monitoring of climateinduced disease risk and decisionsupport tools for timely early warning and impact assessment for proactive preparedness and timely responses the abundance of open data in europe allows the establishment of more effective accessible and costbeneficial prevention and control responses idalert will cocreate novel policyrelevant paneuropean indicators that track past present and future climateinduced disease risk across hazard exposure and vulnerability domains at the animal human and environment interface indicators will be subnational and disaggregated through an inequality lens we will generate tools to assess costbenefit of climate change adaptation and mitigation measures across sectors and scales to reveal novel policy entry points and opportunities surveillance early warning and response systems will be cocreated and prototyped to increase health system resilience at regional and local levels and explicitly reduce socioeconomic inequality indicators and tools will be coproduced through multilevel engagement innovative methodologies existing and new data streams and citizen science taking advantage of intelligence generated from selected hotspots in spain greece the netherlands sweden and bangladesh that are experiencing rapid urban transformation and heterogeneous climateinduced disease threats for implementation idalert has assembled european authorities in climate modelling infectious disease epidemiology social sciences environmental economics one health and ecohealth further by engaging critical stakeholders from the start idalert will ensure longlasting impacts on eu climate policy and provide new evidence and tools for the european green deal to strengthen population health resilience to climate change
twinning to address the pfas challenge in serbia

per and polyfluoroalkyl substances pfas are synthetic chemicals widely used for more than 60 years to make plastics firefighting foams and lubricants and help create stainresistant waterproof and nonstick products however they ended up in the environment and now can be found in the soil water sediment accumulated in human bodies and represent a worldwide challenge the serbian national chemicals legislation recognizes these chemicals but none of the existing scientific or governmental institutions analyze these compounds in addition a solution to the challenge of remediation is not in sight based on a number of publications in peerreviewed journals a number of international projects and a number of students the university of belgrade faculty of chemistry ubfc is one of the leading scientific institutions in serbia this project aims to enhance networking activities between ubfc and two topclass counterparts who are leaders in pfas analysis csic from spain and innovative bioremediation of emerging pollutants brgm from france in addition this project will focus on strengthening the research management capacities and administrative skills of the grant office from ubfc this will be conducted through the development of a scientific strategy for dealing with pfas wp1 knowledge transfer in the field of analysis and bioremediation of emerging pollutants wp2 networking and promoting joint research integrating creativity and developing new approaches for pfas remediation wp3 capacity building of the ubfc grant office wp4 and through dissemination exploitation and communication wp5 the expected impact of pfastwin is to enhance the reputation research and administrative profile and networking channels of ubfc and improve its capability to compete successfully for national eu and international research funding while simultaneously benefiting partner institutions through new contacts skills and collaborations
photonic molecule microcombs

frequency combs are remarkable photonic devices for precision frequency synthesis and metrology the core technology behind conventional frequency combs is a modelocked laser today socalled microcombs constitute an alternative for the generation of a frequency comb on a chipscale microresonator microcombs have a frequency separation between lines that is orders of magnitude larger than standard modelocked lasers the combination of small footprint and large line spacing is opening up entirely new scientific and technological opportunities one of the most prominent ones being optical communications however one outstanding problem with microcombs is their fundamentally limited power conversion efficiency which hampers the potential applications of this otherwise promising technology in my erc cog darkcomb we have overcome this issue by developing an innovative arrangement of linearly coupled microresonators implemented with an original silicon nitride fabrication process that features ultralow optical losses the aim of this erc poc is to conduct a yield analysis of our technology investigate the freedom to operate and pursue a rigorous market evaluation these results will form the basis for the development of a sound business strategy upon the conclusion of the project
decoding animal genomes into cell types

the genome of an animal encodes a large set of regulatory programs that give rise to the thousands of cell types that make up its tissues and organs despite recent progress in singlecell omics our knowledge about the regulatory programs that control the establishment and maintenance of cell type identity remains limited and methods are lacking to infer regulatory programs directly from the genome sequence in this project which lies at the interface between the genome and singlecell atlases we ask how the genome sequence translates into cell types we start with drosophila as model organism its compactness allows sampling of all its cell types and developmental trajectories from egg to adult using wholeorganism singlecell multiomics thus capturing the spectrum of activation states that emerge from the regulatory genome deep learning models will be trained on regulatory sequences to predict and explain gene regulatory networks grn and grn transitions between cell states encoded by enhancers promoters transcription factors tf effector genes and feedback loops based on a better mechanistic understanding we will translate this framework to other animals including octopus birds and mammals and ask how regulatory programs evolve with a focus on neuronal diversity in the brain using new algorithms for crossspecies deep learning and combinatorial optimization we will study how combinations of expressed tfs coevolve with genomic enhancer logic we are unique in our approach because we will develop and use new technological assays deep learning and massively parallel reporter assays and combine these with perturbation experiments and synthetic biology to test our hypotheses after iteratively improving our regulatory models we ultimately aim to predict which regulatory programs and thus which cell types are encoded in an animals genome and how changes in these programs underlie changes in cell types during evolution