Dragon09/odtu_chatbot huggingface dataset:
triboelectric energy generators for selfpowered medical implants

based on intense research efforts in the fields of technology development and materials science a new generation of medical devices has flourished but this medical technology still relies on conventional energy sources bulky batteries these batteries typically have shorter lifetimes than the implant itself meaning limitations on patients activities infections and additional surgeries in an ideal scenario active implantable medical devices aimds would be powered using integrated and fully implantable energy suppliers not needed to be recharged or replaced an integrated implantable energy harvesting device to power aimds is the crucial missing component that would unlock this futuretribomed aims to implement triboelectric energy generators tengs for powering aimds taking vagus nerve stimulation vns as proofofconcept i will show that tengs can be produced at larger scale while being miniaturized and tuned supplying energy levels suitable for driving stimulation implants by coupling to a supercapacitor i aim to develop a fully integrated energy autonomous vns implant on a conformable and biocompatible substrate my approach is timely and innovative because it responds to the increasing needs of energy harvesting and comes when the maturity level reached by thin films technologies allows to start working on device integrationmy background in materials science and my current experience in device technology provides me with the tools necessary for the successful development of tribomed i have the privilege to be working at the forefront of the biomedical research affording insight into the latest achievements and emerging requirements of vns technology tribomed will unlock the use of triboelectricity for feeding other aimds and beyond on the internet of things turning the medical implants into selfpowered systems will broaden the acceptance of the neuromodulation therapies with a lifechanging impact on a very large patient population
welfare on the move female mobility and social care across the early modern adriatic

the welmovfem project explores the interrelation between human mobility and access to premodern welfare within the republic of venice from the 16th to the 18th century the overall objective is to highlight the role of migrant women as both providers and recipients of social protection focusing on their translocal networks and possessions could their geographical mobility influence their capacity to demand certain rights or otherwise affect the institutions abilities to verify the legitimacy of their claim to answer this question the research will not be limited to urban charity institutions but will encompass various forms of aid that moved between venice and its eastern adriatic domains eg financial aid inherited possessions dowries and slave ransoms intertwining a quantitative analysis and an indepth study of the sources will be essential to uncovering the significance of womens material resources in empowering kinship family and community ties even across great distances through the adoption of an interdisciplinary approach which combines gender history with mobility studies and digital humanities the welmovfem project will result in an innovative and ambitious vision of social care in a region that connects various facets of european culture the research data will be accessible to scholars and the wider public through a web digital platform for the humanities which will provide a starting point for future research the projects ultimate aim is to enrich ongoing discussions about migrants rights from a historical perspective enabling eu policymakers to have a longterm view of the current migratory phenomena and raising eu citizens awareness of these global issues the researchers mobility between various academic settings the us italy and croatia will enable her to acquire new interdisciplinary skills expand her social and professional networks and enhance her career opportunities within and outside of academia
oncogenic competence during development when where and why

childhood cancers are believed to be rooted in aberrant development a notion supported by their i generally low mutational burden ii high prevalence of single often epigenetic driver events and iii occurrence during confined developmental periods yet the exact origins of developmental tumours remain one of the principal enigmas of pediatric oncology a prime example are malignant rhabdoid tumours mrts they are astoundingly genomically simple but extremely deadly childhood cancers that arise almost exclusively in the first two years of life and are driven by biallelic inactivation of the swisnf chromatin remodelling complex subunit smarcb1 95 of cases we still do not know what determines oncogenic competence upon smarcb1 loss in particular we wonder 1 what are the cellsoforigin of rhabdoid tumours and what is their normal differentiation potential 2 what is the molecular framework that facilitates oncogenic transformation upon smarcb1 loss 3 what is the contribution of the niche local and systemic to the acquisition of oncogenic competence and considering the epigenetic nature of the oncogenic event 4 is the oncogenic mrt state reversible and howto answer these questions we will combine stateoftheart lineagebarcoded singlecell genomics spatial transcriptomics singlecell resolution wholemount imaging crisprcas9 and epigenomic approaches as well as integrative computational analyses using transgenic mouse induced pluripotent stem cell and patientderived xenograft rhabdoid tumour modelsthis project will provide fundamental insights into the cell autonomous and nonautonomous determinants of oncogenic competence upon smarcb1 loss based on our findings we hope to unlock targeted treatments for mrt patients importantly the conceptual and experimental framework we establish will open up new investigative opportunities for a multitude of developmental cancers
leveraging the impact of gut microbes to advance the efficacy of cart cell immunotherapy

t cell therapy with chimeric antigen receptor cart cells is a curativeintent transformative treatment aimed to boost antitumor abilities of host t cells against refractoryrelapsed b cell malignancies and recently against refractoryrelapsed myeloma major challenges of current cart cell immunotherapies are the loss of longterm efficacy the occurrence of toxicities including infections and a lack of personalized patient strategies including biomarkers for response prediction and interventions to enhance cart cell efficacy this proposal builds on our first evidence for a major role of the gut microbiome in cart cell therapy and addresses these challenges by presenting a translational research strategy aimed to dissect and leverage the impact of gut microbes in its antitumor efficacyin aim 1 we will investigate the hypothesis that gut and intratumoral microbiome configurations and its metabolites are associated with clinical response of cd19cart cells in lymphoma with immunophenotypes of these engineered t cells and the tumor immune microenvironment we will examine the effects of nutrition and antimicrobial drugs on microbiome features to identify potential mechanisms and therapeutic levers in aim 2 we will address the biology of microbiomecart cell interactions through experimental gut microbiome modulations and humanizing mice with patientderived microbial ecologies and individual species and strains in preclinical research models in aim 3 we will assess potential therapeutic interventions to increase cart efficacy by investigating the action of microbiomederived metabolites on cart cells and studying phage and dietbased interventions to mitigate antibioticinduced gut microbiome dysbiosischaracterising the function of the microbiome and its products in cart immunotherapy harbours an enormous potential to improve current and future t cell transfer therapies for numerous patients suffering from cancer
biocatalytic membranes for micronano plastic degradation within waste water effluents

the universal use of different types of plasticbased materials as new products to meet the insatiable global demands of the 20th century has had an unprecedented impact on our evolution as a society unfortunately micro and nanoplastics are now ubiquitous in marine and freshwater environments as well as terrestrial ecosystems where they act as a source of highly detrimental toxic chemicals that negatively affect the environment and human health by interacting with terrestrial organisms that mediate ecosystem services and functions such as soil dwelling invertebrates terrestrial fungi and plant pollinators it is our duty as scientists to provide immediate and appropriate solutions to control the fate and reduce the effects of micronanoplastics on our planetbmrex will develop entirely new concepts for micronanoplastic removal from household and industrial waste water effluents by validating a novel biocatalystbased membrane reactor technology to degrade plastic waste avoiding further damage the consortium will produce test optimize biocatalytic membrane reactors based on porous inorganic scaffolds functionalized with ionic liquid materials modified for biofouling resistance plastic affinity and controlled attachment of plasticdegrading enzymes interchangeable enzyme species will permit a precise control of stepwise catalytic processes enhanced with artificial cytosis maximizing activity and stability of the biocatalytic reactions bmrex will also evaluate the economic and technological viability of this novel technology with its unique integration of scientific approaches competences and resources bmrex has the potential to open up an entirely new technological fieldin the long term this project aims to enable an in situ more efficient and safer recycling of waste waters with transformative effects on a society that is currently in the very early phases of transitioning toward an environmentally sustainable use of plastic
island timelines to quantify biodiversity change

one of the most exciting and important research questions in ecology and palaeoecology is how fast where and why biodiversity is changing heated debate on the topic within the scientific community reflects observations of apparently heterogeneous rates of change across the world biodiversity responses to different types of drivers of change remain underexplored because to study these phenomena over the necessary span of years often centuries to millennia patterns and processes must be inferred from fossil records there is also evidence that geographical attributes may mediate biodiversity responses to drivers of change creating further complexity that biodiversity change is spatially structured is the main hypothesis of timelines which will examine 5000 years of plant biodiversity change and the drivers of that change using a range of highquality palaeoecological records derived from sedimentary sequences from islands worldwide islands are often described as hotspots of biodiversity and natural laboratories with legacies of relatively recent human impacts for the first time it is feasible to build palaeoecological networks at biogeographical scales timelines will first establish the historical ranges of variability for both drivers of change and biodiversity aligning information on the magnitude of biodiversity change with the geographic properties of islands can then address whether change both at taxonomic and functional levels is mediated by geographical context the results will open new research horizons bringing palaeoecology and biogeography together and developing methods to quantify the effects of drivers of changenot only for islands but elsewhere and in much greater depth than has been possible to date from these findings we can address to what degree historically informed baselines and change trajectories have utility for sustainable biodiversity management
democracy dies in darkness without official data

my main ambitious is to put at the centre of the debate the official statistics in democracy for policymakers researchers and all the citizens in my experience i noticed that at times also within the national statistics offices nsos they do not know the importance that nso has for democracy and policymakers democracy dies in darkness without official data official statistics is a public good it is vital for democracy i want to analyze the empirical and theoretical relation between official statistics and democracy and formalize ten new variables that official statistics should produce and disseminate to improve society economy and the relationship among countries a key word in my project is the word multidisciplinary those disciplines are among others statistics economics and political sciencethe relation between democracy and official statistics is an almost unexplored scientific topic with economical and societal worldwide impact media and policymakers use the official data everyday because national statistics offices nsos are in every single countrythe official statistics are produced and disseminated by the nso every day we listen to the news about the employment rate the gdp mortality rate car accidents etc all these statistics are collected produced and then disseminated by the nsos around the world also covid data should be produced and disseminated by nsos as i explained in one of the top journals on official statistics see di gennaro 2020 can we organize political elections without an independent and trustable official data produced and disseminated by the national official statistics offices for instance trustable data on employment rate and national economic growth gross domestic product gdp are critical for the voters that want to evaluate the government my research is in line with the value of the european union and united nations and the sustainable development goals
synthetic generation of hematological data over federated computing frameworks

haematological diseases hds are a large group of disorders resulting from quantitative or qualitative abnormalities of blood cells lymphoid organs and coagulation factors despite most of them 74 are rare the overall number of hd affected patients worldwide is important placing a considerable economic burden on healthcare systems and societies despite the existence of several collaborative research groups at national and eu level current clinical approaches are often ineffective particularly for rarest conditions due to the relatively low number of patients per disease and the high number of unconnected clinical entities synthema aims to establish a crossborder data hub where to develop and validate innovative aibased techniques for clinical data anonymisation and synthetic data generation sdg to tackle the scarcity and fragmentation of data and widen the basis for gdprcompliant research in rhds the project will focus on two representative rhd use cases sicklecell disease scd and acute myeloid leukaemia amlsynthema will develop a federated learning fl infrastructure equipped with secure multiparty computation smpc and differential privacy df protocols connecting clinical centres bringing standardised interoperable multimodal datasets and computing centres from academia and sme this framework will be utilised to train the developed algorithms and perform smpcbased global model aggregation in a privacypreserving fashion the resulting data will be validated for their clinical value statistical utility and residual privacy risks the project will develop legal and ethical frameworks to guarantee privacy bydesign in the collection and processing of healthrelated personal data and attain an ethicswise algorithm cocreation project outcomes including pipelines standards and data will be made openly available to stakeholders in the healthcare academia and industry field and contribute to existing rare disease registries
uncovering the human subcortical pathway for auditory threat detection

fast detection of threats is one of the most important abilities for survival as it allows efficiently responding to potential harms in humans such advantage extends well into other cognitive domains including social communication threat detection is paramount in all sensory modalities but is probably most adaptive in audition however research on the neural substrates of fast threat detection in humans has been almost exclusively dedicated to vision the key neural pathway for visual fast threat detection is the socalled subcortical route for emotion having pulled through millions of years of evolution this shortcut conveys crude direct sensory inputs from the thalamus to the amygdala facilitating a prompt emotional response in the auditory domain evidence from nonhuman animals suggests that a similar fast route may exist but it has never been described in humans here i aim at testing the hypothesis that this auditory subcortical route indeed exists in our species with neuroanatomical and functional properties that support an optimal response to threat using stateoftheart electrophysiological and neuroimaging techniques scalp and intracranial electroencephalography functional magnetic resonance and diffusionweighted imaging i will identify a pathway compatible with this route and test its functional and temporal dynamics relative to a cortical route each technique will provide essential information for thoroughly depicting the route beyond its function i will examine its link to traits associated to psychiatric conditions then to confirm its anatomical existence in humans i will microscopically track its connections directly in postmortem brains humansubthreat will restructure current dominant models of human affective neuroscience strongly biased towards vision and provide a novel view towards the understanding of disorders associated to amygdala dysfunction
extragalactic stellar streams as astrophysical tools to decipher dark matter

stellar streams are sensitive to both the distribution of dark matter and the population of dark matter subhalos in galaxies which both vary depending on the nature of the dark matter particle in galaxies beyond the milky way extragalactic systems we can apply a hierarchical inference approach where we draw from expected distributions to look at thousands of stellar stream properties in a statistical sense my proposed research will lay the theoretical groundwork and fill the missing gaps in our knowledge of streams in external galaxies to prepare for the wealth of incoming stellar stream data materializing over the next decade from the nancy grace roman space telescope the vera c rubin observatory and euclid the objectives of this proposal is 1 to map where the missing thin stellar streams from globular clusters which are most sensitive to perturbations from subhalos are located in external galaxies 2 to develop tools to recover dark matter potentials from stellar streams in external galaxies and 3 to place constraints on dark matter substructure through statistical analyses of streams and underdensities in dwarf galaxies to achieve these objectives i will analyze publicly released catalogs of globular cluster formation and evolution models develop numerical techniques to model multiple streams at once in external galaxies and run stateoftheart nbody simulations of disrupting globular clusters in dwarfs this work will facilitate direct comparisons between upcoming data and models from various dark matter particle candidate predictions my proposed work provides a fundamental method of mapping the otherwise invisible dark matter and will impact the interdisciplinary direction of dark matter research in both particle physics and astrophysics
startup of the soill support structure for soil living labs

the a soil deal for europe mission aims to accelerate the transition to healthy soils by 2030 through the establishment of 100 soil health living labs and lighthouses shlllhs that will drive the development and adoption of solutions the framework partnership soill led by enoll the international association of certified living labs has been created to coordinate support expand and promote the network of 100 shlllhs during the initial two years of soill the soillstartup project will collaborate with the first waves of shlllhs and key stakeholders to launch the soill onestop structure this involves 1 establishing a highquality structure for shlllhs with clear processes and procedures a webbased hub will be created to facilitate outreach collaboration support and monitoring within and beyond the 100 shlllhs network 2 providing comprehensive support to shlllhs for a harmonized and sustainable approach within the network this includes capacity building through training and supporting tools on methodologies technical aspects and crosscutting areas regular monitoring and evaluation of shlllhs will be conducted based on a consolidated assessment framework 3 supporting network expansion by promoting engaging matchmaking and advising applicants to mission calls events will be organized to showcase funding opportunities provide examples and disseminate information on the shlllh concept and its implementation webinars coaching and matchmaking will assist applicants in conceptualization and consortia creation for their applications 4 facilitating knowledge exchange collaboration and synergy creation within the shlllhs network and the wider community soillstartup will enhance the visibility and accessibility of the shlllhs their work and achievements mutuallearning events collaborative platforms mutual visits and matchmaking will facilitate collaboration opportunities knowledge sharing and solution uptake
impact monitor 2

impact monitor 2 is a project to deliver a coherent and holistic toolbox and framework including their application to preliminary impact assessments of ri from horizon europe projects clean aviation and sesar 3 that will be the reference choice for the definition and assessment of environmental climate and competitiveness policy options of european aviation ri and regulatory measures bolstered by its profound knowledge and multidisciplinary expertise a consortium consisting of 10 research establishments and academic institutes deliver this toolbox and framework with preliminary impact assessments by building on the experience and outcomes of the project from horizoncl52022d50114 of the same consortium and by exploiting the consortiums close working relationships with ec eg dgs clima move env and rtd clean aviation sesar 3 and easa this toolbox and framework advance the already established reference toolbox and framework developed in that project through enhancing the systematic approach to perform coherent and holistic impact assessments of european aviation ri and the support to key stakeholders in sciencebased informed policy decisionmaking for european aviation ri with improved analysis capabilities and newly integrated impact models assessments are carried out for both smr and lr vehicles for climate environment and competitiveness