Dragon09/odtu_chatbot huggingface dataset:
functionalized porous organic cages for adsorption and photodegradation of per and polyfluoroalkyl substances pfas

increasing energy consumption depletion of natural resources and environmental pollution are nowadays among the biggest economic and social challenges per and polyfluoroalkyl substances pfas also known as forever chemicals are persistent emerging pollutants not naturally degraded in the environment pfas are anthropogenic compounds with harmful health effects inert and resistant to heat and nowadays found in water air and soil thus posing a heavy impact on our environment adsorption on activated carbon ionexchange resins cyclodextrins and nanofiltration are the methods currently used or under study for pfas removal from water however critical gaps such as the adsorbent regeneration affinity production of secondary waste analytical method limitations and efficient pfas degradation pathways are major challenges photoclean aims to synthesize novel palladium functionalized solventresponsive nanocage adsorbents able to remove pfas from water the nanocages will promote rapid pfas photodegradation being excited by visiblelight to a photoexcited state able to interact with pfas through a single electron transfer depending on the energy of the photoexcited state pfas decomposition is expected to be initiated either through oxidative or reductive events and be sustained by the formation of radicals the new approach proposed by photoclean is based on the development of reusable adsorbent cages and the exploitation of visiblelight as the energy source to activate pfas decomposition it thus constitutes an environmentally sustainable strategy for pfas removal and degradation the project will contribute to understand fundamental structureproperty relationships of pfas adsorption on nanoporous organic cages and integrate photodegradation of pfas with catalytic activity the action has the potential to revolutionize methods for pfas removal from water and tackles a variety of scientific and societal challenges of environmental importance
citizenpowered data ecosystems for inclusive and green urban transitions

urban releaf is an actionoriented mission to advance citizenpowered science as a central resource for inclusive urban green planning in support of local policy making european strategies and monitoring systems eg the green deal copernicus and global efforts such as the sdgs eg target 117 and geoss the project will i assess current urban greening policy processes within six european cities and cocreate solutions that use citizen observations to complement existing data ecosystems and decisionmaking ii support the validation and longterm inclusion of active and passive data from citizens for urban environmental monitoring within authoritative data streams including geoss copernicus iii mobilize and empower communities through widespread participation in issues of public interest surrounding urban green infrastructure iv develop a community of practice around topics related to the use of citizen observations for urban planning to foster knowledge exchange and develop capacities across multiple sectors v produce flexible and innovative governance solutions to help scaleout inclusive urban green transitions in support of the european green deal and un sustainable development goals and iv promote recognition adoption and trust of citizen observations and other novel data ecosystems for environmental monitoring to trigger innovation within public institutions the project is coordinated by iiasa who led the weobserve project and involves partners from previous successful h2020 citizen observatory projects and as well as six cities athens cascais dundee mannheim riga utrecht that are willing to embrace new data streams for urban greening planning and policy making and to fully engage with citizens including marginalized and vulnerable groups urban releaf is also supported by technology partners and those with strong links to copernicus and geo
development of a new therapeutic product targeting neuroimmune circuits to treat asthma

asthma affects approximately 3 of the population and results in 1000 daily deaths it is characterized by chronic lung inflammation and airway hyperresponsiveness first lines of treatment have not evolved in the last decades and actual developments are essentially focusing on severe asthma management 7 of patients via the targeting of inflammatory mediators unfortunately 60 of asthmatics still suffer from uncontrolled symptomsthe lungs are innervated by peripheral neurons expressing specific sets of g proteincoupled receptors gpcr that contribute to bronchoconstriction and regulate allergic immune response among the broad family of gpcrs the gpcrx has never been studied in a pathological context albeit human and murine orthologs share a remarkable sequence identity we have created a new transgenic mouse gpcrxmut allowing both to track the receptor expression and to interrogate its function in vivo the gpcrxmut mouse exhibits normal immune and sensory systems at steady state our data demonstrate that a gpcrx is expressed by both peripheral neurons and certain lungresident immune cells b the selective invalidation of gpcrx completely protects against the development of asthma in various models and c lung biopsies from asthmatic patients show high expression of gpcrx in neurons and immune cellsthe erc proof of concept project immception 2 aims to develop a selective antagonist for gpcrx to treat asthmatic patients we will 1 miniaturize our established screening system for antagonists 2 identify leads capable of specifically blocking gpcrx and 3 develop a new mouse model humanized for the gpcrx to further validate identified leads in vivo the research program has been carefully designed to leverage our expertise in neurobiology immunology asthma and clinical allergy and has the potential to lead to the development of a new oral molecule with a dual mode of action to silence lung neuroimmune circuits
omitted from history how workers on indias building sites mediated twentiethcentury modernity

omhi aims to complicate hegemonic and linear understandings of modernisation in indias 20thcentury urban and architectural historiography by tapping into the experience of lesser studied and often marginalized actors who built indias modern cities investigations of urban transformation as it occurred on the ground rather than on the drawing table will provide new insights into how building practice was or was not shaped by the interplay between local building traditions and aspirations and neocolonial influences as they intersected with the major social economic and political developments of high modernity including indias independence in 1947 the project focuses on the city of pune 19171992 and involves uncelebrated architects building contractors engineers and construction workers and their descendants in a process of participatory knowledge making that examines two unusual datasets photographs and oral recollections the historiographical objective is to identify changes and continuities in construction work and their implications for architectural change methodologically the project will advance the state of the art in construction historiography by testing novel participatory techniques for data collection and interpretation both in digital and analogue form such methods are highly needed to reveal more plural histories that include perspectives from below omhi integrates research and training while ensuring reciprocal knowledge transfers it is shaped by interdisciplinary and intersectoral collaborations that will significantly expand my global network and train me in new cuttingedge skills in the field of postcolonial architectural history digital humanities visual analysis and open science collected data will be digitally archived to stimulate longterm cooperation between south asian and european scholars from different research fields related to the built environment cultural studies and postcolonial studies
deciphering the regulatory logic of cortical development

the mammalian cortex is the most complex region of the brain responsible for higher cognitive functions abnormal cortical development often translates into prominent neuropsychiatric diseases which affect different neuronal subtypes with unique molecular and morphological features increasing evidence suggests that epigenetic regulation is essential for cortical development but how multiple regulatory layers are coordinated to specify distinct neuronal lineages in vivo remains unclearmy team and i recently applied singlecell rnaseq singlecell atacseq together with celltypespecific dna methylation and 3d genome measurements to map the regulatory landscape of neural differentiation at a single embryonic stage in vivo however the process of neuronal subtype specification involves multiple distinct waves of differentiation over several consecutive days therefore to decode the molecular logic of temporal cellular identity in the cortex i will comprehensively dissect the interplay between gene expression chromatin topology and epigenetics in specifying cell fate in order to accomplish this i will build upon my extensive experimental and computational expertise to 1 map the regulatory landscape of the developing mouse cortex across multiple regulatory layers and timepoints in single cells 2 identify and validate cisregulatory elements via a novel massive parallel celltype specific reporter assay in vivo and 3 determine the functional consequences of perturbing enhancers and silencers using a highly multiplexed singlecell approach collectively epicortex will provide unprecedented insights and establish new paradigms into the interplay between transcription factors epigenome dynamics and gene expression in development it will allow us to better understand the molecular logic of lineage specification in the mammalian cortex and more precisely define compare and ultimately engineer cellular identities for therapeutic and regenerative purposes
ultraefficient and stable perovskite tandem solar cells for extreme conditions in space

inperspace focuses on an emerging but extremely urgent challenge in europe meeting the sharply increasing demand for spacegrade photovoltaics pvs due to the recent privatization of the space industry todays modern iiivgebased pvs fall short of answering this demand as the new space era requires costeffective and highspeed processable pvs on top of the existing high power density requirement allperovskite tandem pvs are excellent candidates fulfilling all these requirements however their stability must be ensured under synergistic extremes from ground to orbit deployment such as high vacuum particle radiation high ultraviolet light frequent temperature cycles in orbit vibrations in flight and humidity before liftoff unless these concerns are addressed we risk substantially underutilizing the emerging space technologies in the new space erainperspace aims to realize this with two core pillars 1 creating ultraefficient 30 at space spectrum allperovskite tandem solar cells on lightweight substrates 2 investigating the fundamental failure modes of these devices under synergistic stressors typical of the extreme space environment focusing on combinations of stressors with thermal cycling as the most decisive yet frequently overlooked stressor for stability in space i will achieve these goals by i creating new perovskite compositions to eliminate the performance losses ii elucidating the origin of the instability of the devices from nano to macroscale and module level iii implementing groundbreaking methodologies to solve stability issuesinperspace is an exceptionally timely and exciting research project the created knowledge will immediately revolutionize the space pv market and set the agenda in other domains such as perovskitebased terrestrial pvs and other optoelectronic devices the work realises the promise of a versatile pv technology envisaged to be part of lifechanging technologies for billions of people
cocreative improved understanding and awareness of multihazard risks for disaster resilient society

there is a lack of data understanding and awareness in europe and in the world of compound weather and climate extremes insufficient governance function also affect the related vulnerability risk and resilience of people communities and places the c2impress project aims to bring a radical paradigm shift to disaster and hazard research and innovation by moving away from traditional hazard centric approach framework to a novel place and people centred integrated multihazard risk and resilient assessment framework guided by this framework the c2impress project aims to offer an ensemble of innovative revolutionary models methods frameworks tools and technologies that are holistic and robust enough to provide appropriate finegrained spatiotemporal qualitative and quantitative data locally appropriate solutions better prediction with lower uncertainty on risks of single or multiple hazards stemming from extreme weather events like floods wildfires etc under different climate change scenarios breakthrough innovations from c2impress project will be systemofsystems for multihazard risk intelligence network sos4mhrin platform supported by the robust earth system dynamic intelligence esdi and information physical artificial intelligence ipai innovative agent based model polycentric risk governance multiactor decision support microservices and a suite of citizen engagement technologies and tools as well as novel codesign and cocreation approach for sociotechnical innovations knowledge production and validation to empower citizens and society with climate actions for a sustainable transition to a just risk resilient society with these social and technical innovations as novel processes and products the c2impress project will provide better understanding and public awareness on multihazard risks the associated multidimensional impacts vulnerabilities and resilience of extreme weather events in 4 case study areas in europe
architecture of peripheral neuroimmune circuits and synapses

maintenance of health requires the coordination of multiple cellular networks for example the immune and nervous systems cooperate to regulate tissue homeostasis in agreement our recent work demonstrates that innate lymphoid cells ilc integrate neuronal signals to control tissue health and immunity these findings are provoking a paradigm shift in our understanding of the immune response neuroimmune crosstalk and its potential therapeutic value nevertheless the dynamics of neuroimmune modalities remain elusive and progress in the field has been hindered by the lack of approaches to explore the identity and plasticity of neuroimmune interactions in vivohere we hypothesise that dynamic circuitry codes orchestrate neuroilc2 interactions and disease outcomes to test this hypothesis we have developed a set of disruptive intercellular labelling neuroimmune toolboxes that we termed kiss and lipstic and which can probe the dynamics of neuroilc2 axes in vivo with cellular specificity and singlecell resolution using these innovative platforms we plan to unravel the architecture of pulmonary neuroilc2 circuits and to define cellular identities outcomes and plasticity at the neuroimmune interface sequentially we propose to unravel unappreciated neuroilc2 synaptic communication and to define the ultrastructure of theses intercellular entities using highresolution imaging finally by conditionally harnessing the activity of synaptic neuronal partners during airway inflammation and infection we will investigate their impact on ilc2 their environment and on disease progressiontogether these experiments will tackle multiple facets of pioneer frontier questions bringing to bear an array of cuttingedge technologies to address and advance with unprecedented mechanistic and conceptual detail how the neuroimmune interactome unfolds in health and disease
affordable and sustainable selfpowered glucose sensing system for a global fair diabetes management

fairglucose proposes a low cost sustainable and selfpowered standalone glucose sensing system that relies on the wellknown oxidation process of glucose coming from finger prick blood and transfers it to a voltage readout through an innovative and extremely simple strategy in this way a measurement that typically requires a potentiostat with a microcontroller and a battery is performed here with a minimalistic and batteryless circuit that fits within the footprint of a commercial glucose strip this allows for a reduction not only in device cost but also in the generation of waste of electrical and electronic equipment weee or ewaste avoiding the cumulative effect of millions of tests and their corresponding batteries performed at remote sites away from adequate recycling infrastructures in order to interpret the result the strip can be integrated in a card format that translates voltage into level bars accounting for low normal and high glucose indicators a solution that would substitute urine strips or into a more sophisticated but still lowcost card containing a nfc chip allowing the transferring of a numeric result into a cell phone both cards could be implemented with stateofthe art flexible electronics technologies and could be reused infinite times as energy would always come from the sample the first targeted market of fairglucose solutions is located in low and middleincome countries where cost of current glucometers limits severely the selfmonitoring of blood glucose among population however at midterm it is likely that the sustainability and affordability of the approach displaces the current glucose players in some market niches of developed countries and generates new applications in the healthcare and agrofood arena thus fairglucose aims to investigate the commercial feasibility of this disruptive approach and create an innovation roadmap that allows deploying the technology where it can make the most
technology based impact assessment tool for sustainable transparent deep sea mining exploration and exploitation

trident aims to contribute to a sustainable exploitation of seabed mineral resources by developing a reliable transparent and costeffective system for prediction and continuous environmental impact monitoring of exploration and exploitation activities in the deep sea this system will develop and integrate technology and novel solutions to operate autonomously in remote areas under extreme conditions and provide realtime data to permitting and supervising authorities the effective monitoring and inspection system to be developed will comply with international and national legal frameworkstrident will identify all relevant physical chemical geological and biological parameters to be measured at the sea surface midwater and seabed the project will also identify gaps in existing data sets and develop solutions to address them these are essential steps to develop statistically robust environmental baselines establish reliable indicators of good environmental status and define thresholds for significant impact enabling the standardization of tools and methods the project consortium will subsequently develop and test an integrated system of static and mobile observatory platforms equipped with the latest automatic sensors and samplers to measure environmental parameters on mining and reference areas at representative spatial and temporal scales to support quick actions for preventing serious harm to the environment the system will implement highcapacity data handling pipelines able to collect transmit process and display monitoring data in near real time finally we will provide technological and systemic solutions for forecasting potential environmental impacts of using the developed monitoring and mitigation methods
reversibly designed cross linked polymers

redondo will develop reversibly crosslinked polyethylene rpex rendering the uptodate nonrecyclable pex a recyclablebydesign innovative polymer achievement of reversibility will be conducted via two different thermally reversible reactions for pe crosslinking one based on css bonds and one exploiting the diels alder reaction the produced rpex will be characterized and its reversibility assessed key to this project is the adoption of the safetybydesign and sustainabilitybydesign frameworks incorporating the outcomes of safety and sustainabilityrelated assessments already from the design stage in the polymer formulation process use of innovative green and biobased additives lpns and mfc will enable for further improvement of desired properties thermal stability mechanical properties and flammability without introducing health risks or jeopardizing the environmental sustainability of the materials and processes nanolignin lnps and nanocellulose mfc are being produced and studied as rpex additives for the first time an inventory of additives tool will enable further adoption of this approach two high potential impact enduse applications have been placed under focus pipes and photovoltaic cables the efficiency of the adopted approach and technologies will be demonstrated and validated according to the specification and requirements of endusers moreover a number of analyses will be performed to evaluate the safety and sustainability of rpex but also to establish the safety and sustainabilitybydesign criteria and the recyclability requirements this will facilitate the extension of this concept to other enduse applications of rpex or to the design and development of other crosslinked not currently recyclable polymers as reversible ones
computational models for new patients stratification strategies of neuromuscular disorders

the compassnmd project creates novel and universal tools for the diagnostic stratification of patients suffering from hereditary neuromuscular diseases hnmds aiming at personalised treatments hnmds often occurs in young people causing longterm disability and early death these conditions bring lack of participation need for permanent assistance and may require longterm institutionalisation multidimensional hnmd data clinical genetic histopathological and mri will be provided by thirdlevel clinical centers in italy france germany finland and the united kingdom as part of the european reference network for rare neurological diseases computational tools for highdimensional clustering will be applied in an unsupervised learning approach using the internal structure of data to define groups of similar patients classification model averaging and integration techniques for federated learninginspired model building and novel hnmdspecific descriptors of histopathological images will be implemented the adoption of this multidimensional view has the potential to increment the diagnostic rate of hnmds by 30 and foster effective actions by european national health systemsas main project outcome the compassnmd atlas platform will be a costeffective aibased application providing precise clinical characterization and diagnosis with data remaining publicly available for anyone in the research and health community to use the project will deliver recommendations and guidelines for stratificationbased patient management to offer superior standardofcare for diagnosis and prognosis and assist in planning clinical trials it will follow a usercentred codesign methodology with a strong stakeholder engagement and networking with other project consortiathe project engages partners with clinical biotechnological ict ai ethical and legal communication and exploitation competences 6 clinicalacademic centres 1 academic 4 industrial partners