Dragon09/odtu_chatbot huggingface dataset:
valence band engineering of oxidation materials for cheap and sustainable solar fuel production

given the need to reduce our greenhouse gas emissions and our dependence on fossil fuels there is a great interest in the development of solar fuels and especially solar h2 however the production cost of solar h2 is still not yet competitive current strategies rely on converting water into h2 and o2 a lowvalueadded molecule this is because process feasibility was based on the reduction halfreaction with the oxidation halfreaction being secondary in omatsolfuel the focus is shifted instead to the oxidation halfreaction i will develop routes for the photoconversion of model glucose reactive mixtures and richglucose industrial mixtures they are cheap renewable and could help micro industries become selfsufficient in fuels and energy instead of simply generating h2 and o2 the glucose will be photocatalytically converted into highvalueadded molecules eg arabinose or erythrose and h2 these molecules would be highly interesting for plummeting the cost of solar h2 and replacing molecules produced by the petrochemical industry to reach this objective i will design efficient and selective photocatalysts based on oxynitrides and novel chalcogenides structures the main efforts will be on the electronic structure engineering by adjusting the s 3p n 2p o 2p and metallic d orbitals to shift the valence band maximum and the oxidation potential of the photogenerated holes closer to the targeted glucose oxidation potentials powders and thin films will be synthesized by soft route methods and chemical or physical vapor deposition methods the resulting morphology structural and electronic properties will be characterized with the wellequipped platform of the institut des matriaux de nantes imn and in particular with photoelectron spectroscopy
beyond stateoftheart battery recycling by increasing the selectivity and specificity of efficient preprocessing technologies

europe aims to reach climate neutrality and a circular economy by 2050 current practices to recycle batteries are not designed for the full valorisation of the battery materials and therefore are not coherent with the european ambitions to design the vertical battery recycling process compatible with the requirements of circular economy beyondbattrec aims at integrating emerging technological and digital tools to enhance the battery recycling rate the project introduces innovative principles and practices at the component level and rationally integrates the developed components to recover valuable materials with a constant focus on carbon footprint according to the request in annex ii of the new eu directive eu 20191020 to achieve its objective beyondbattrec puts together a multidisciplinary 13partner consortium from 7 european member states consisting of industries academia and research technology organizations the project targets battery recyclers manufacturers and technology providers as the end users due to their importance in realizing the objectives of batt4eu in transforming european battery industry to make it circular and achieve overall climate neutrality at eu level by 2050 while enhancing their global competitiveness thanks to innovative steps beyond state of art beyondbattrec will allow to comply also with other 2 annexes of the above directive annex x for management of materials subject to risk of supply for europe and annex xii related to minimum recovery rate for said risky and strategic metals and requesting the following recovery rate at the horizon of 2031 a 95 for cobalt b 95 for cooper c 80 for lithiumd 95 for nickelbeyondbattrec builds on the success of former initiatives and projects which have delivered technological methodological patents and largely europe dissemination under join venture and licenses thanks to those community assets beyondbattrec will convincingly and coherently leverage and advance to achieve its objectives
renovation packages for holistic improvement of eus buildings efficiency maximizing res generation and costeffectiveness

the main objective of rehouse is to develop and demonstrate 8 renovation packages of promising technology innovations until trl7 the renovation packages are fully designed for a wide range of building renovation actions including deep renovations that overcome the main barriers that slow down the current eu renovation ratios following circularity principles including multifunctionality through activepassive elements integration prefabrication and offsite construction of components and respect of buildings aesthetics architectural and historic value rehouse also implements an inclusive peoplecentric social engagement strategy to endow the renovation wave with a resident and owner perspective towards affordability satisfaction and attractiveness of sustainable renovationthe renovation packages will be deployed across 4 locations serving as demonstrators located in greece italy france and hungary these buildings renovations include detailed design pilot setup demonstration and evaluation to validate in operational conditions social the prototypes of the 8 renovation packages rehouse proposes solutions that cover together a set of 5 renovation principles offering technically and economically affordable renovation solutions with enough flexibility to tackle almost 100 of the building renovation challenges at eu level the aim is to boost market uptake scalability and replicability of rehouse renovation packages linking its value proposition with critical economic technical social regulatory and data securityprotection aspects and barriers and propose practical recommendations on how to overcome them
recovering past stories for the future a synergistic approach to textual and oral heritage of small communities

the project builds synergistically upon textual and oral stories to explore the past of small communities with the goal of restoring the publics emotional connection to discontinued traditions in doing so it pays greater attention to segments of cultural heritage that have long been overshadowed by monuments or sites of larger significance texts and interviews encapsulate expressions of collective agency allowing currentday ssh academics to investigate those natural processes that gave prominence to the effective management of limited supplies of human and material resources with a focus on schooling recycling practices and affectivebased communication of group agents restory intends to investigate the formation of sustainable attitudes and strategies learn from the lessons of the past and integrate them into the future configuration of commitments ultimately emulating the resource maximization frameworks intuitively designed by smallscale communities over a long period of time will allow the transfer of knowhow from academia to local memory institutions stakeholders and citizens contributing to the sustainable development of the continuously transformative heritage contexts the research aspects of the project will consist of methodologicallyhybrid case studies targeting the textual and oral heritage of the communities inhabited in the past by transylvanian saxons a group of germanspeaking colonists settled about 800 years ago in nowadays romania in conjunction with 10 international case studies all offering a wider range of expertise and accumulation of knowledge within the research target restory also presents the opportunity to attract cultural professionals from archives museums and libraries to training sessions designed to enhance the correct and comprehensive management conservation and capitalization of cultural heritage all in relation to the needs of the wider public and administrative decisionmakers at a local level
reconstituting cytoplasm mechanics

the cytoplasm is not a simple waterlike liquid it is a crowded heterogeneous medium filled with macromolecules active cytoskeleton networks and endomembranes this rich rheology must be precisely coordinated to regulate fundamental cellular processes such as molecular diffusion or cell division however while the material properties of the cytoplasm have been well studied at the nanoscale relevant to eg protein diffusion its regulation at the scale of larger assemblies like nuclei or mitotic spindles remains poorly addressed recent results from the host team suggest that cytoplasm fluid mechanics play a key role in the regulation of cell division of large cells that mark the development of early embryos in this cytomech project i thus aim to address how cytoplasm mechanics is regulated during early embryo development i hypothesize that endomembrane vesicles tubules and sheets form a crowded polydisperse suspension close to jamming that dominate cytoplasm rheology at the scale of large objects like nuclei or mitotic spindle relevant to early embryo morphogenesis using sea urchin embryos as a model i will first combine advanced imaging of the cytoplasm with active measurements of cytoplasm mechanics using in vivo magnetic tweezers to address how this endomembrane suspension evolves during early embryogenesis to modulate cytoplasm material properties along with embryo development then using an artificial cell approach i propose to reconstitute cytoplasm mechanics by encapsulating different cytoplasm extract fractions enriched in various sets of endomembranes in waterinoil droplets and use this assay to perform a mechanical screen of the cytoplasm cytomech will represent a breakthrough for our current understanding of how spatiotemporal changes of cytoplasm composition organization and activity support cell division and embryo morphogenesis as well as a unique training opportunity for the applicant to become an independent researcher
new pathways for equitable climate action in line with the paris agreement and sustainable development

there is an urgent need to strengthen collective action to limit global warming to levels consistent with the longterm objective of the paris agreement the newpathways project aims to inform solutions to strengthen action by developing and analysing nextgeneration parisaligned global and national lowemission transformation pathways for the next global stocktake in 2028 the project objectives are to promote enhanced transparency consistency and clarity of ghg emission reduction commitments identify opportunities to leverage equity and finance to strengthen collective climate action and establish new national and global transformation pathways that limit temporary overshoot rely on deep sectoral transformations combine climate and nature protection and are aligned with sustainable development and just transition objectives the project will rely on a multilevel stakeholder dialogue to cocreate knowledge and build user capacity to maximize relevance and uptake of its results the newpathways consortium combines strong global and national pathway modelling capacity with expertise from the social sciences economics and policy analysis national modelling teams come from a diverse set of countries in the americas asia africa and europe covering two thirds of global greenhouse gas emissions the robust global and diverse national modelling capabilities with simultaneous access to global and national policy debates will prove effective in providing critical information to global and national policymakers and stakeholders for strengthening climate action towards achieving the longterm objective of the paris agreement
personalized cancer primary prevention research through citizen participation and digitally enabled social innovation

with a strong belief that primary prevention of cancer represents a collective responsibility citizens professionals decisionmakers during a 4 year period 4pcan builds on an innovative vision to understand the complex system that surrounds the citizen the person and how it increases the risk for cancer on three major levels macro at the national level mesomezzo at the community level and micro at the individual level following the european code against cancer recommendations as a narrative reference and combining implementation research including economic sciences social sciences and humanities ssh together with behavioral sciences and innovative technological approaches 4pcan ultimately delivers new personalized tools for primary prevention of cancer in central and eastern european countries from the consortium the cocreated knowledge is then used to personalize the primary prevention interventions through livinglabs and implement personalized communication campaigns on cancer prevention the project will focus on some of the main modifiable risk factors for cancer occurrence smoking alcohol consumption physical inactivity excess body weight overweight and obesity hpv and hbv infections preventable through vaccination as well as environmental pollution including radon and the understanding of the barriers in front of the policy implementation and individual adherence to healthy behaviors in countries from eastern europe romania bulgaria republic of moldova north macedonia montenegro ukraine to improve as a consequence the primary prevention activities and reduce the inequalities altogether 17 organizations from 11 different countries are getting together to achieve these goals ie balkan countries eu member states and noneu member states part of cee romania bulgaria north macedonia montenegro republic of moldova and ukraine and western eu countries portugal italy france ireland belgiumthis action is part of the cancer mission cluster of projects on prevention and early detection
innovative methodology based in circular economy and artificial intelligence to foster the transition to sustainable and very high energy performance buildings at a cost optimal level

buildings are responsible for over 40 of the energy consumption and co2 emissions in eu accordingly the ce has stablished ambitious building standard aiming to transform all existing buildings into zebs by 2050 to reach a fully decarbonised building stocksnug aims to demonstrate on three real buildings with different characteristics uses and climatology the application of an innovative methodology to support planners of new buildings or retrofitting works in selecting the most appropriate set of insulation materials their combination and placement to maximise the energy efficiency and minimize ghg emissions of the building throughout its life cycle to make its zeb rating more easily achievable considering specific building characteristics and its environment at an optimal cost level this methodology will be supported bya digital tool assistant based on ai and virtual simulation which will range several final options of thermal insulation materials and layouts based on benchmarks predictions related with energy demand operational and embedded energy sustainability safe security and cost and particular features of buildingsinnovative sustainablebydesign thermal insulation materials and lightweight prefab solutions ready to the market deployment based on circular economy smart andor renewable materials able to improve energy efficiency and sustainability of buildings in comparison with current market solutions at a competitive costinsulation materials database including technical and lca information innovative thermal insulation solutions will be incorporated including current solutions in the market this database will be released as an open data outcomea digital building logbook collecting all the information about the buildings throughout their whole life in a digital and interoperable format with bim and the dta this dbl will facilitate decision making and information sharing within the construction sector and stakeholders
novel current control for climate neutral energy infrastructure

low voltage dc power systems are one of the most promising technologies for a clean and efficient energy transition especially for local generation and storage however safety considerations prevent rapid adoption of the proposed solutions our project aims at developing new current limiting cl technology based on highmobility materials and the extraordinary magnetoresistance emr effect as well as their integration into direct current dcand hybrid acdc microgrid infrastructures a system design approach will be adopted to find device layouts suitable for five selected usecases native dcsupply loads battery systems photovoltaic microgrids and bidirectional ev supply equipment evse to enable the v2x focus on v2g technology deployment the devices are fabricated and tested for proof of concept the potential of this technology is further evaluated by simulation means aiming at standardization and the development of dc and hybrid microgrids steady state operation strategies the proposed research results in passive multifunctional more robust and safer cl devices for dc applications with reduced cost size and environmental footprint when compared to the stateoftheartour technology can be a breakthrough for circuit protection aiming at demonstrating through endtoend designtoapplication innovation design supported by lca guidance simulation fabrication and labbased testing that a comprehensive advanced solution encompassing emrenabled current limiting devices can meet the current needs of the dc microgrid market it can establish european industrial leadership with a technology that is critical for the ongoing energy transition which makes it a suitable goal for the european green deal
the quest for oceanic sediments within the ancient martian sedimentary record

the martian missions have gradually revealed that mars abounds with evidence of a full ancient hydrological system favourable to life emergence if so there is every reasons to believe that mars has hosted a hemispheric ocean covering the northern lowlands this hypothesis is as old as mars exploration but has been repeatedly challenged over the past two decades the case of primitive martian ocean remains one of the planets most controversial and unsolved issue recent discoveries are reopening this question mainly highlighting that the main oceanic activity may be older than we thought with related deposits partly exhumed and two rovers mars2020nasa arrived in 2021 and exomarsesaroskosmos to be launched in 2022 have landing sites in the oldest terrains never explored on mars displaying sediments possibly linked with an ocean system to wind up the debate the identification of ancient deposits of the same age same composition with a global distribution in agreement with a possible ocean level is required but such clues are small scale exposures solved only by highresolution orbital data set 10 to of data or by in situ exploration preventing a forward link to the global context oceanid proposes to face this challenge by investigating at different scale global mesoscale and microscale using complementary dataset orbital in situ and experimental data oceanid will also lie on innovative methodology of orbital data mining geological object recognition by artificial intelligence erosiondeposition evolution models clustering from multitype of dataoceanid objectives are to describe the early martian sedimentary record accumulated below possible global ocean levels to establish a finescale chronology of primitive events to contextualize mars2020 and exomars missions within the global ancient hydrological system and to correlate the oceanic context the transient water cycle and the mineralogy observed both from orbit and in situ
menstrual blood multiomics analysis to better diagnose understand and treat endometriosis

the mensendodiag project aims at finding diagnostic biomarkers and prognostic biomarker candidates as well as investigating new therapeutic approaches for endometriosis using menstrual fluid an easily accessible yet overlooked biological fluidendometriosis is a common gynecological disorder affecting 610 of women of childbearing age it is associated with pelvic pain and infertility it leads to a reduced quality of life and is an economic burden it is defined by the presence of endometrial tissue outside the uterus endometriotic lesion form from retrograde menstruation menstrual fluid reflux through the fallopian tubes but the precise pathogenesis remains unclear there are no noninvasive biomarkers currently used in clinical care but they are essential to improve the diagnosis delay currently estimated at 8 years there is no specific treatment and pharmacological options are contraceptive here i propose to use menstrual fluid as a relevant biological fluid for endometriosisin aim 1 singlecell transcriptomics and soluble protein multiplex assays on 64 menstrual fluid samples will be used to identify candidate diagnostic biomarkers that differentiate endometriosis affected women from healthy controls validation of these biomarkers will be carried out in menstrual fluid samples from 250 women in aim 2 menstrual fluid derived organoids cultured with or without immune cells will be used to assess endometriosis associated functional changes and to test new immunomodulatory treatments in aim 3 longitudinal cohorts will be established to identify prognostic candidate biomarkers for response to surgery and in vitro fertilizationdiagnostic and prognostic biomarkers are essential to assess disease establishment evolution and to choose the most appropriate treatment this project will enhance our understanding of endometriosis pathophysiology as well as allow the study of a new biological fluid relevant to gynecologic and reproductive disorders
structural and functional characterization of different states of the arginine vasopressin v2 receptor

g proteincoupled receptors gpcr are the largest superfamily of cell surface signaling membrane proteins and the targets of 30 of marketed drugs for many human diseases they respond to diverse extracellular stimuli by transmitting the signal across the membrane and activating a number of intracellular signaling pathways to sense these stimuli and couple to signaling partners such as g proteins these transmembrane domains have a high conformational flexibility representing a challenge for structure determination both improvements of gpcr expression and purification and the cryoem revolution have led to structurally characterized gpcr to better understand these signaling key players however defining active states of a given receptor is still a difficult challenge that led to success only for a dozen different gpcr this project focus on the characterization of different states of the arginine vasopressin avp v2 receptor v2r the v2r is considered as a receptor model for small peptides and hormones and is a crucial therapeutic target the atomic resolution data will contribute to a better knowledge of the v2r transmembrane signaling the comparison of the different active states of the v2r to the inactive state of v2r will provide key information for deciphering the molecular events leading to receptor activation then blocking the v2r with antagonists is a validated therapeutic avenue for two unmet medical needs hyponatremia and autosomal dominant polycystic kidney disease v2r interacts not only with gs protein but also with arrestins the development of biased agonists that selectively activate or inhibit one signaling cascade among all triggered by the natural hormone is also a very promising therapeutic line keeping in mind the interest of antagonistsinverse agonists and biased agonists of the v2r for human health we expect our data will have a major impact on drug discovery in addition to be of general interest in terms of scientific impact