Dragon09/odtu_chatbot huggingface dataset:
breaking oncometabolites dynamics for nextgeneration dendritic cells tumor immunotherapy

owing to an increased appreciation of the potential for immunotherapy in neoplasia much attention has been focuing on a greater understanding of the immune bidirectional intricacies involving the tumor microenvironment tme recent work has demonstrated that tme elicits environmental changes metabolic in nature in the hosts immune cells that dampen their ability to react against tumors manipulating the biology of oncometabolites can strengthen an antitumor immune response as well as circumvent therapy resistance here i propose innovative modalities to tackle this problem the aryl hydrocarbon receptor ahr best known as the receptor for dioxins has recently been shown to be one central node for communication between hosts cells and its ligands disparate as the nature and source i have recently found that selective ahr deletion in a subset of antigen presenting cells triggers the rejection of an otherwise progressive fibrosarcoma tumor in vivo i thus hypothesize that ahr expressed in orchestrators of immune responsiveness represents a key sensor of tme composition influencing the outcome of an immune reaction against tumors the main objective of this project is to identify ahractivating metabolites in tme and disclose their impact on tumor rejection or progression in parallel i aim at developing novel advanced strategies with a high degree of translatability to human cells to specifically inhibit ahr or ahrdependent programs in selected apcs i will combine stateoftheart technology with new and powerful technologies including advanced singlecell analysis promoter geneediting approaches and computational chemistry the potential of such a project is very high because such metabolites may be predictors of immune activation or suppression in tme and the downstream targets of those immunesuppressive oncometabiltes may represent druggable targets to inhibit tumor escape mechanisms
bugs4urate precision nutrition strategies for investigating probiotic diet glycan and microbiome factors in hyperuricemia and gout prevention

gout is a prevalent lifestyle related ncd on the rise in europe causing low quality of life yet with inefficient means for treatment an effective approach to manage hyperuricemia the precursor to gout would significantly enhance health outcomes and have a profound impactusing a novel probiotic foodingredient with uratelowering properties we target the gut microbiome to eradicate urate in a precision nutrition framework where contextualizing factors of the habitual diet host gut microbiome and host genetics is used to establish a responder nonresponder instrument we will employ a diverse array of methods encompassing machine learning applied to existing clinical and omics observational data exvivo dietary fiber and probiotic refinement and two human intervention studies in healthy adults n 8 we will conduct a modeofaction study utilizing a crossover design including small intestine biopsy sampling to assess local activity in hyperuricemic participants n 99 we will conduct a threearmed placebocontrolled proofofconcept study to access the efficacy of probiotic treatment with and without fibre combined with a responder nonresponder instrument using comprehensive longitudinal analyses in metabolomics microbiome transcriptomics and glycomics we aim to uncover the molecular dynamics between dietary patterns established bacterial enzymatic processes urate breakdown and the resultant shifts in inflammation within the gut and throughout the circulatory system by innovating the glycomics technology to accommodate alternative biospecimens we hope to enable straightforward home sampling and initiate early diagnostic procedures for broad population oversight through the application of multiomics we aim to develop an effective responder nonresponder instrument to probiotic intervention for serum urate reduction inflammation control and gout prevention
cyclic derivations for recursive operators

modal fixpoint logics which express recursive notions find several fundamental applications in computer science as a key example in formal verification recursively defined notions are needed to reason about iterations of programs a second prominent example comes from knowledge representation where common knowledge of groups of agents is formalised through recursion much as in basic modal logics the semantics of modal fixpoint logics can be enriched with additional properties called frame conditions to capture specific attitudes frame conditions give rise to rich and expressive families of modal fixpoint logics proof theory is the discipline that studies proof systems which are sets of axioms and rules used to check validity of a formula proof systems play a central role in the analysis of logical systems despite their wide range of applications the proof theory of modal fixpoint logics is currently underdeveloped more specifically the proof theory of modal fixpoint logics with frame conditions is much less advanced than the proof theory of modal or intuitionistic logics the key objective of cyder is to define proof systems for modal fixpoint logics with frame conditions providing a general prooftheoretical framework for these logics towards this challenging aim cyder will define two new kinds of proof systems labelled and nested cyclic proofs cyder prooftheoretical methodology is inspired by labelled and nested sequents which capture modal logics with frame conditions and cyclic proofs which are a powerful formalism to treat recursion the project will define cyclic proof systems for several systems of modal fixpoint logics epistemic logics with common knowledge the alternationfree modal mucalculus with frame conditions intuitionistic modal logics with recursive modalities and dynamic epistemic logics
costeffective processing and refining of lithium into lithium hydroxide from strategic european multimineral lithium hardrock projects

on 16 march 2023 the ec published the critical raw materials act crma setting benchmarks along the strategic raw materials value chain and for the diversification of eu supplies by targeting the domestic processing and refining of lithium arguably the most strategic crm lithos directly contributes to the 1st and 2nd crma benchmarks 10 domestic extraction 40 domestic processing lithos processes and refines the ores from three strategic projects in terms of domestic batterygrade liohh2o production two spodumenebearing pegmatite cases kelibers deposits in the kaustinen region finland savannahs barroso lithium project portugal and one raremetal granite rmg case imerys beauvoir mine in france lithos expands and tailors the existing keliber mo flowsheet which was developed for regulargrade spodumene ores so that 1 the cutoff grade for spodumene ores is reduced resulting in larger li reserves while 2 allowing the commercialisation of lowergrade pegmatite and rmg deposits lithos triggers innovations along the value chain mineral processing concentrate pretreatment hydrometallurgical refining making it possible to deal with different levels and types of impurities in nonspodumene li minerals lepidolite petalite lithos gives specific attention to closedloop water systems in the mineral processing kpi 90 less water consumption the overall co2 emissions of the lithos flowsheet will be 50 lower than todays benchmark production of spodumene concentrate in australia refining in china this work is enriched by bespoke thermodynamic modelling and digital twins supported by fmg euromines lithos intends to replicate the lithos responsible mining and refining concept to the other 24 identified lihardrock deposits in europe lithoss metaobjective is to unleash europes full lihardrock ore potential total 88 mt li2o so as to become selfsufficient by 203035 in terms of madeineurope liohh2o
scaling up research in ssa countries in infectious diseases africaneuropean training network in integrated health informatics and data sciences

an africaneuropean consortium of 6 ssa countries and 3 european countries gathering 12 partners is proposing a unique and innovative scalable training program and network that will produce empowered infectious diseases experts to lead and drive research from and for subsahara africa ssa at levels of earlystage career postgraduate certification and doctoral and midstage career postdoctoral in an integrated program of health informatics and data sciences bridge program the program consortium will set up 5 centre of excellence coes in ssa countries benin ethiopia uganda kenya rwanda and south africa the coes will serve as training setting field research setting and a hub for harmonized infectious diseases data and all will recruit candidates from their countries for certification program doctoral and postdoctoral fellowships but only 3 coes will be the degree awarding institutions the degree awarding coes have been selected based on the existing university capacity to offer a degree awarding program or built on the existing partnerships between selected ssa public health institutes and local universities with degree awarding programs capacity the program leverages the established collaborations between european and ssa institutions utilizing accumulated medical data including electronic health records registries and biobanks at the end of 54 months program will have strengthened the institutional research leading capacities with at least 20 trainees per coe with postgraduate certification a total of 10 graduates with phds and a total of 4 postdoctoral fellows skilled for harmonizing and analysing fragmented large data to derive datadriven insights and guide health policies the coes embedded within public health institutions with continuous mentorship from an international scientific community and a ready to use large amount of data ensure the sustainability of training and collaborative research beyond the program grant
reversing t cell dysfunction in cancer by multimodal genetic screening

t cell dysfunction is a key problem in cancer enabling not only tumorigenesis but also causing resistance to immunotherapy induction of immune checkpoints is a hallmark of t cell dysfunction but clinical blockade by pd1 and ctla4 antibodies solves this problem for few patients only dysfunction is driven also by additional mechanisms including chronic stimulation and metabolic insufficiency a better mechanistic understanding will be imperative for improving immunotherapy my laboratory recently launched revert a genomewide crisprcas9 screening program to identify genes ablation of which reverses dysfunction in primary t cells to derisk this application we have already successfully completed three such screens in vitro for chronic antigen stimulation metabolic stress and pd1 induction validating and characterizing several dysfunction genes not previously reported furthermore an independent followup rescreen with a dysfunction reversion candidate drc minilibrary containing the top 100 hits of each of these screens validated 100 genes that reversed t cell dysfunction in vitro here we will carry out the most challenging and important step to systematically validate and mechanistically characterize this collection of t cell dysfunction genes in vivo this will be done in a pooled and multimodal fashion analyzing multiple dysfunction phenotypes in parallel specifically immune checkpoints exhaustion metabolism recruitment and proliferation our proofofconcept results indicate that the drc library contains nodal factors operating in several seemingly different dysfunction settings which may thus in fact be linked we will use a collection of adoptive cell transfer mouse and human tumor models for validation and mechanistic characterization as well as primary human t cells in patientderived tumor fragments lastly we will translate our findings to a preclinical setting aiming to achieve more durable clinical responses
european partnership animal health and welfare

the european partnership animal health welfare eup ahw will provide society with a sustainable production for both terrestrial and aquatic animals where infectious animal diseases are prevented and controlled antimicrobials are used prudently and a high level of animal welfare is provided in every phase of animals life the objectives of the eup ahw fit in with the european green deal and its associated farm to fork strategy for a fair healthy and environmentally friendly food system from its start the eup ahw includes 56 research performing organizations rpo and 30 funding organizations fo from 24 eu and noneu european countries the rpo partners provide significant researchbased advice to competent authorities in the eu and are the backbone of animal health welfare ahw research in europe they collaborated to transpose 16 actions from the eup strategic research and innovation agenda eup sria into 17 joint internal projects the fo partners will contribute through external calls to further ri actions from the eup sria not covered by internal activities as they require other expertise or industry participations due to the close link between animal health and welfare and human wellbeing the one healthone welfare perspective will take a prominent place in the eup ahw the mobilisation of resources from both rpo and fo together with ec cofunding will allow the partnership to achieve ambitious goals for ahw at the transnational level in europe and beyond new technologies develop rapidly and provide new ri opportunities for ahw to be included in the eup ahw as joint internal activities and projects initiated through external calls the management will set up appropriate procedures and methodologies to ensure a fair coverage of ahw of terrestrial and aquatic animal species the various priority areas and to ensure the uptake of the results in the midterm outcomes and long term impact for science society and policy
ibechange addressing psychosocial and lifestyle risk factors to promote primary cancer prevention an integrated platform to promote behavioural change

europes beating cancer plan set has ambitious goals addressing key behavioral risk factors for cancer development such as tobacco target reduction of 30 by 2025 alcohol consumption target reduction of 10 by 2025 unhealthy diets and physical inactivity see also the healthylifestyle4all campaign as about 40 of cancer cases in the eu are preventable health promotion and preventive measures for cancer can benefit from the implementation of behavioural change bc and emotional management em in the general population however previous research and practice have generally failed to achieve sustainable bc due to two factors 1 not taking into account recent bc concepts showing the need of personalizing interventions and techniques
a primitive solar atmosphere around the young earth

the existence of an atmosphere enriched in h and he around the earth as it formed has often been proposed one hypothesis suggests that it could have been captured from the gas present in the protoplanetary disk before its evaporation subsequently a secondary atmosphere would have been degassed or brought in by a late veneer of chondriticcometary material although this model is regularly evoked using giant planets for comparison there is no geological proof for its existence except possibly for the neon in the earths mantle while the model has a flaw mainly relating to chronology as the gas from the disk is lost in 6 my while the earth formed over a period of more than 30my the solartype neon in the earths mantle is an argument for the existence of such a captured atmosphere which partially dissolved into a magma ocean a second scenario for a primordial h2herich atmosphere is the degassing of a mantle that contained implanted solar wind the apate project aims to study the isotopic composition of neon in the earths mantle in order to determine if this composition is the same as that of the nebula or the solar wind material i will investigate the degassing processes of magmas experimentally and numerically in order to study the isotopic fractionation that occurs during bubble formation and to determine whether the measured neon isotopic composition can provide an accurate composition for the original mantle the project aims to calculate the amount of neon that can be incorporated into a magma ocean by establishing the atmospheric pressure of the captured atmosphere and by studying the dynamics of the magma ocean i will also explore the hypothesis involving solar wind irradiation using simulations of irradiation i will identify those conditions under which this model is realistic and its implications for the earths isotopicchemical composition the origin of light solar volatiles will then be explored by the apate project
transforming european work and social protection a new proactive welfare state fit for the future world of work

for the last two decades european countries have faced unprecedented structural changes due to digitalisation automation the internationalisation of the workforce and the transition towards a green economy how national and eulevel interventions will mediate the effects of these transformations will profoundly impact the future of european citizens the economy and political stability transeuroworks multilevel comparative and multimethod strategy for scientific and social impact is driven by an understanding that social protection must be sustainable inclusive and mobile to address the complex and interlocking transformations of the near future the project examines eight policy areas unemployment sickness oldage insurances retraining worklife balance family and care policies gender equality foreign labour recruitment and freedom of movement combining conventional protection policies with the more contemporary social investment approaches through research in 27 eumember states and 2 noneu countries we address 5 levels relevant to the transforming world of work and social protection individuals households workplaces countries and the eu transeuroworks centres attention on social diversity including gender ethnicity education employment type age and household composition in its methodology the mixedmethods design of the project including an original survey on public opinion survey and field experiments and interviews with company managers and policymakers will bring new knowledge on the analysis of existing policies and necessary adjustment measures transeuroworks will codesign research tools with social stakeholders engage in policy feedback loops with eu and national policymakers coproduce innovations and solicit feedback from citizens thus transeuroworks is formulated to bring research with the greatest potential social impact to support europes residents and a more cohesive equal inclusive and green future
holistic ugvbased resilient and realtime intelligence for crisis and natural emergency

according to the world meteorological organization the frequency of severe weather incidents has quintupled over the last five decades causing more than 100 000 fatalities and 15 trillion euros of economic losses in europe eu consequently disaster management capabilities need to be enhanced in this fastevolving context robotics can play a crucial role to improve first responders safety and effectiveness in their operations hurricane is a 15 partners multidisciplinary consortium aiming to overcome limitations that are still holding back these cuttingedge innovations from becoming a disaster management standardhurricane will unlock the potential of ugv operation in hazardous environment relying on enhanced vision capabilities and smart integration over a holistic resilient and realtime situational awareness infrastructure that includes innovative uavugv cooperation pathways laserbased charging uav supporting ugv regarding route planning and multitechnology communication infrastructure 5g rf optical wireless datadriven optimization models will provide recommendations through a userfriendly api to support frs tactics three complementary pilots will be implemented to demonstrate the benefits brought by hurricane solutions in several challenging environments periurban areas corsica mountains alps and wildfires andalusia last but not least euwide advanced training modules will be implemented to raise awareness among fr about these innovative technologies integrating new operational procedures at the end of the project hurricane will show improved hazard management efficiency 60 operation time reduction 95 false positive readout reduction with reduced fr exposure to harmful situations strengthened eu robotics industry leadership 5m of revenues and 50 jobs in 2028 training will be provided for 100 frs across 15 eu countries aiming to achieve a total of 10000 trained frs by the year 2035
miniaturized plasma emission spectroscopybased breath analysis for unobtrusive athome monitoring and prediction of copd exacerbations

patients suffering from chronic obstructive pulmonary disease copd suffer from persistent airway obstruction causing shortness of breath and extreme fatigue patients are repeatedly hospitalized due to acute flareups known as exacerbations which are largely responsible for the morbidity and mortality associated with copd exacerbations are diagnosed based on symptoms only and diagnosis is often too late there is an urgent need for a reliable technology for unobtrusive and continuous athome monitoring of copd patients to enable timely exacerbation prediction and treatment the breathsense consortium aims to develop the firstever handheld breathalyzer for noninvasive detection of breath biomarkers respiq has developed a breakthrough plasma emission spectroscopybased breath analysis technology and will collaborate with sensor development expert sintef userexperience and cocreation expert nell and clinical copd specialist kcl the consortium will combine innovative technological advancements with humancentric userexperience research to develop and validate a transformative clinical workflow for athome monitoring of copd patients with this digital biomarkerbased monitoring solution patients and clinicians will benefit from reliable and timely prediction of exacerbations leading to early treatment intervention and preventing up to 95 hospitalizations the breathsense workflow will deliver a paradigm shift in copd management from symptombased delayed diagnosis towards preventative athome monitoring prior to symptom worseningultimately the breathalyzer technology is a platform technology that can be applicable for a wide range of respiratory and gastrointestinal diseases that could also be monitored better continuously at home such as asthma lung cancer and ibs since novel biomarkers can be incorporated for different disease indications as such the breathsense technology has the potential to improve the health of millions of people
methodologies for assessing the real costs to health of environmental stressors

to underpin regular use of integrated economic and health modeling in impact assessments and socioeconomic analysis by public authorities the marches project aims to advance methodological rigor and consistency in accounting for the welfare economic health costs of air pollution and drinking water nitrate based on systematic reviews of health effects and by extending the consensus on established approaches on premature mortality with disabilityadjustment of the associated morbidity burdens while developing europeanwide exposure modeling for integrated assessment based on expert and stakeholder consultations the project will provide guidelines and unit prices for an accounting approach that can be applied routinely by eu and national authorities subject to data availability and policy scenarios this will be demonstrated in case studies with public authorities in five member states cz dk ee es se and in one westbalkan country xk