Dragon09/odtu_chatbot huggingface dataset:
fostering a humancentered trustworthy and sustainable internet

the overall objective of trustchain is to create a portfolio of next generation internet protocols and an ecosystem of decentralised software solutions that reach the highest standards of humanity such as those chartered by the united nations including the respect of human rights ethics sustainability energy efficiency our care for the environment and our respect for the worlds cultural history trustchain will tackle several challenges pertaining to trustworthy and reliable digital identity to resilient secure and reliable data pathways to economics and trading of data to energy efficiency for data storage transport and sharing to seamless services and data flows a new trustworthy data governance and sharing model in line with the european regulatory framework and taking into account european values will be developed that will ensure trusted data ecosystemsthird party top internet innovators will be selected through 5 open calls focus on topics of the 1 decentralised digital identity 2 the user privacy and data governance 3 economics and democracy 4 multi chains support for ngi protocols and 5 green scalable and sustainable dlts which is an essential need of the daytrustchain addresses the second research area of the human 0103 call in particular to tackle the current limitations of decentralised technologies such as blockchain and dlt including those related to scalability interoperability energy efficiency privacy or security in order to make them dependable building blocks of the future internet trustchain will explore dltbased solutions enabling the exploitation of data coming from a high number and various types of sources eliminating data silos through decentralised and interoperable approaches while helping individuals and organisations better govern their data when they participate in joint value chains where cooperating partners can also be competitors
creating framework conditions for research management to strengthen the european research area

rm roadmap creating framework conditions for research management to strengthen the european research area will create a roadmap for the future of research management rm in europe and a community to support its delivery to enhance access to excellence the overarching objective of rm roadmap is to identify and adapt the research management capital base of the eu including the widening countries of its current and future research management workforce to emerging needs to improve the eus competitiveness and sustain its economic performance the rm roadmap consortium is proposing a stateoftheart paneuropean network of research managers supporting the establishment of strategic crossborder partnerships between research managers in industry research funding organisations higher education and research institutions rm roadmap will connect existing european networks on a smart community platform which will enable an unprecedented cocreation process in research management in the world this cocreation process will gather the existing communities and expand upon them to reach two main objectives1 create and inform a bottomup consensus on the future of rm in a roadmap and 2 inform the community about existing training networking funding and mobility opportunities rm roadmap consists of 8 partners european association of research managers and administrators belgium hetfa research institute hungary nova university lisbon portugal association of european science technology transfer professionals netherlands crowdhelix limited ireland the cyprus institute cyprus and associated partners janssen janssen and una europa belgium
diagnostic tools and risk protocols to accelerate underground hydrogen storage

the overall goal of the hydra project is the characterisation of hydrogenconsuming microbial activity and interaction with the storage formation to determine guiding principles that mitigate risk and enable fasttracking of porous media underground storage as part of the european hydrogen ecosystem our goal is achieved through 10 quantifiable key objectives including standardized field sampling protocols and biogeochemical laboratory methods mapping microbial taxonomic and functional diversity across europe deriving models that enhance and upscale laboratory biogeochemical findings for sitespecific microbial risk assessment delivering a fasttrack site selection tool with predictive microbial risk index updating guidelines to support storage site operators ssos in their sitespecific risk identification and management targeting the full diversity of geology and subsurface conditions encountered across the different european storage sites the interdisciplinary hydra research partners and associated ssos will assess microbial risks associated with the storage of hydrogen in porous reservoirs across 12 work packages the hydra project will generate new fundamental understanding of microbial risk and mitigation in the context of underground hydrogen storage with an interdependent workflow across relevant disciplines microbiology geosciences geophysics and chemistry porous media modelling and safetyrisk assessment hydra research focuses on the elusive interplay between microbiology geochemistry and hydrogen flow during underground hydrogen storage in porous media addressing this knowledge gap across the full spectrum of site and operational conditions for active and future hydrogen storage sites amplified by natural hydrogen seeps will support the development and standardization of sitespecific and general guidelines and regulation codes for an accelerated and widespread european underground hydrogen storage deployment
social sciences for democracy a training program for improving research on illiberal systems and finding ways to build more robust democracies

the turn to illiberalism often combined with antieuropean rhetoric represents a serious threat to the european union with most of the research focused on poland and hungary the emergence of illiberal trends in other countries including slovenia bosnia and herzegovina turkey and italy has often been neglected to fill this gap the sos4democracy project aims to create an alliance of research and highereducation institutions civil society associations and a private news media organization to develop effective training programs for enhancing research on the recent turn to authoritarian systems in southeastern europe in line with the working program the project will pursue three major objectives firstly the project will strengthen cooperation and improve research and innovation ecosystems in academic and nonacademic organizations by developing a trainingthroughresearch program to equip researchers journalists and civil society activists with the conceptual and methodological tools needed to explore the impact of illiberal measures in the participating countries the trainingthroughresearch program will be carried out during secondments involving 31 staff members secondly to ensure the transfer of knowhow between the academic and nonacademic sectors the project will develop the following training programs the academic sector will provide training on advanced research methods and practical skills the news media organization will provide media training while nongovernmental organizations will provide training on civic monitoring mechanisms public advocacy and the use of new technology in civil society organizing the extensive transfer of know how will be carried out on secondments inperson networking events and webinars thirdly to improve the overall ri capacity of all participating organizations the project will organize a training program on research management knowledge brokering data stewardship and knowledge transfer
realtime finegrained air quality monitoring with intelligent and robust multiuav networks

air pollution is a significant global concern causing an estimated 42 million deaths annually due to diseases related to poor air quality climate change is exacerbating air quality issues and posing unprecedented challenges to the existing air quality monitoring systems which mainly utilize sparse and expensive terrestrial stations and satellites leading to limited accuracy and flexibility to address these challenges refine aims to form an international multidisciplinary and crosssectoral consortium with worldleading researchers to create a novel realtime finegrained air quality monitoring system empowered by advanced technologies in unmanned aerial vehicles uavs artificial intelligence ai and wireless networkingspecifically refine will pioneer research and innovations ri on groundbreaking technologies including 1 a robust and scalable system architecture for aerialterrestrial air quality monitoring 2 intelligent and efficient multiuav cooperation strategies for dynamic and flexible area coverage 3 ultraresilient and secure aerialterrestrial networking schemes for reliable and efficient data transmission 4 lightweight and robust ai methods for accurate and realtime air quality analysis refine will establish a longterm crossdisciplinary and crosssectoral knowledgesharing platform with competent and complementary expertise in computer science environmental science and communication engineering the researchers involved will be trained through substantial ri actions and wellplanned networking activities at both european and global levels to enrich their skills and enhance their career perspectivesrefine will significantly contribute to achieving the eus zeropollution ambition and enhancing european competitiveness through transforming the current air quality monitoring systems into a new generation which is able to provide realtime intelligent monitoring of vast rural areas with higher precision and efficiency
bringing the plastic waste transformation by the insects at scale

the traditional linear plastic industry business model results in an evergrowing amount of accumulated waste which contributes significantly to the negative environmental impact of the global plastic industry one of the biggest issues concerning the recycling of used polymeric materials packaging textile furniture is the handling of complex waste streams consisting of mixtures copolymers and other recalcitrant materials such as thermosets nonmelting plastics foams that can be only burned or disposed of on the landfills yet neither of these solutions is acceptable from the environmental point of view therefore the new regulations and eu directives aim to limit these methodswe have developed a novel approach towards handling of complex plastic waste streams where there is no available recycling alternative thanks to under patent technologies the approach is based on one specific insect galleria mellonella the greater wax moth and we have developed a scalable vertical farming process that enables the insects to digest and transform polymeric materials into proteins lipids and biofertilizers the longterm goal of this developed process is an environmentallysound and commerciallysuccessful transformation facilitywinscale focuses on the scaling up of the transformation process namely it focuses on the biochemical and technological development of the solution applied to two specifically difficult waste streams sludge coming from the waste treating companies and polyurethane foam coming from matrass recycling facilitieswinscale enables the overall improvement of the investor readiness of the developed solution contributes to the creation of new crosssectoral value chains of waste transformation to added value products thus promoting european competitiveness in the knowledgebased modern economy and womens leadership in the deep tech industry
gene therapy for treatment of rare inherited arrhythmogenic cardiomyopathy

development of a cure for rare cardiac diseases is a risky costly and timeconsuming process which is hampered by insufficient insight into pathophysiological mechanisms of the diseases and lack of relevant disease models the geremy consortium proposes to overcome this challenge by developing a gene therapy gt for inherited arrhythmogenic cardiomyopathy acm by targeting the diseasecausing pln nondesmosomes and pkp2 cardiac desmosomes mutations the geremy consortium will apply a unique parallel approach and investigate various promising gt approaches oligonucleotide chemistries gene editing and gene delivery also the consortium will engineer disease models for proper assessment of therapeutic interventions and aims to provide in vitro in vivo preclinical proofofconcept for the gta significant benefit compared to current technologies is that the gt has the potential to be a curative treatment for rare cardiac diseases based on previous successes geremy will target pln pkp2 as a roadmap of the technology restoring the primary defect in the pln pkp2 genes that cause the disease will lead to preserving or even restoring myocardial contractility through this approach geremy will work towards a curative treatment of inherited acm and likely other cardiomyopathies which significantly reduces the healthcare burden the projects experts in preclinical research and cardiac genetics will deliver preclinical efficacy and safety data for the mutation correction the partners with regulatory and clinical trial expertise exom euf nlhi will prepare for immediate start of clinical trials upon project completion and apply for orphan drug designation eupati a patient organisation and kul ethics partner will ensure that the project is continuously aligned with patient needs and ethical perspectives the whole consortium will contribute to communicate an disseminate the results to ensure maximum exploitation of this breakthrough technology
immune photoactivated cancer therapy for the treatment of upper tract urothelial cancer utuc and other solid tumours

utuc is a nonsystemically treatable cancer that forms in the renal pelvis or ureter frequently recurring due to ineffective systemic chemotherapy with 510 of urothelial cancers being utuc current surgical treatment solutions pose significant hardships on patients and decrease their quality of life our proprietary solution padeliporfinvtp therapy offers a minimally invasive and effective alternative to surgery this therapy delivers an inactive photosensitizer drug that is precisely activated in the tumour microenvironment by nonthermal laser light immediately impeding the tumours blood supply leading to cell death with minimal effect on healthy tissues this treatment not only effectively eliminates tumours but also preserves organ functionality for potential future treatments this project is led by a team of accomplished professionals in the pharmaceutical and biopharma industry which solidifies our capability in innovating bestinclass therapeutic solutions utilising this funding we aim to achieve regulatory approval trl9 scale production and achieve market penetration in a market projected to reach 439b by 2032
room temperature superradiant perovskite lasers

coherent light sources are limited to stateofthe art lasers such as freeelectron gas or solidstate semiconductor gain media stabilized to highquality optical cavities however the mirrors in these cavities vibrate as a result of thermal noise causing timeintegrated phase drifts that limit the laser linewidth to achieving high power and extremely narrow linewidth resembling that of single optical transitions while also finding pathways for ewaste reduction requires ingenious solutions in both gain material and device design but still remain elusivesuperlaser aims to change the field of lasing by developing green lowcost solutionprocessable efficient and ultranarrow linewidth superradiant halide perovskite lasers this goal will be accomplished by predicting and developing targets to transforming coherent light generation through scientific designs and strategic developments at the material and device level towards synergistic outcomes across scientific technological and ecological boundaries the project prioritizes research innovation and sustainability focusing on the prediction of halide perovskites with strong inherent spu and the successful development of continuous superlatticesbased on the predicted materials these superradiant emitters are expected to act as topological lasers without any additional cavity requirements due to photonic crystal properties endowed by their nontrivial topology they will be applied as gain media combined with energaticallymatched charge transport materials to fabricate the first electrically pumbed perovskite lasers working at room temperature finally we will apply recycle and reuse protocols to ensure zero ewaste for the developed technology
investigating the conjectures of finegrained complexity

finegrained complexity theory identifies a small set of conjectures under which a large number of hardness results hold the fastgrowing list of such conditional hardness results already spans many diverse areas of computer science improved algorithms for some of the most central problems in these domains are deemed impossible unless one of the core conjectures turns out to be false terminating decadeslong quests for faster algorithms much research is going into closing the remaining gaps addressing more domains and achieving beyondworstcase resultsbut should these conjectures that are the foundation of this entire theory really be treated as laws of nature in addition to three primary conjectures the community has put forth about ten others these secondary conjectures are often stronger variants of the primary conjectures stating that the core problems remain hard despite introducing new assumptions on the input they let us prove more hardness results but are also less extensively studied and less likely to be true compared to the original conjecturesstepping away from current research that is hustling towards achieving tight bounds for all important problems under such conjectures this project aims to investigate the conjectures themselves our main objective is to resolve the secondary conjectures either by falsifying them or by establishing their equivalence to a primary conjecture either of these two outcomes would be satisfying refuting a conjecture must involve disruptive algorithmic techniques impacting numerous other problems unifying a secondary conjecture with an original primary conjecture reinforces the validity of the conjecture and all its implications solidifying the very foundations of finegrained complexity we believe that there is a pressing need for such an investigation of this rapidly growing theory
protein phototermal optomechanical analyzer

labelfree detection and discerning of single proteins is essential to reduce the impact of degenerative diseases eg cancer by its ultraearly detection as well as to expand our understanding on the processes taking place in living beings the objective of this project is developing a new technique for the optomechanical labelfree detection and characterization of single protein the working principle of the proposed technique consist on illuminating a protein and transferring its photothermal heating to a suspended membrane on which it is adsorbed this suspended membrane can mechanically oscillate in drumlike modes so as the protein transfers its heat to the membrane its mechanical properties will change producing a shift in its resonance frequency therefore tracking the resonance frequency as a function of the incident lights wavelength will allow discerning among different proteins by obtaining their absorption spectraon the other hand prophotom will have a high impact on my career implemented at tu delft and supervised by prof peter g steeneken and dr farbod alijani this project will allow introducing myself into new subjects which the supervisors master 2d materials and condensed matter physics furthermore the supervisors will benefit from my wide expertise on mechanical resonators for the optical characterization of biological samples which guarantees the twoway transfer of knowledge in addition to the scientific training this project will also provide me different nonscientific skills increasing my competencies and employability while allowing me developing an international networkeventually this project will contribute significantly to europes economic and societal advance providing knowledge in different subjects biophysics biochemistry or medicine and new technologies contributing to the achievement of the uns sustainable development goals sdg 3 9 and horizon europe missions hem cancer
revealing elusive light particles with cosmic microwave background surveys across cosmological scales

neutrinos and other wellmotivated particles from the big bang are gateways to much awaited new physics that will sharpen our understanding of nature cosmology offers a unique arena to unveil their secrets in a way that is separate from but complementary to astrophysical and terrestrial searches the next generation of cosmological surveys will supersede the current which is already highly sensitive to these particles fundamental properties the firstever measurement of the neutrino mass scale a handle to its beyondstandardmodel origin has never been so close a novel approach to data exploitation is both necessary and timely perfect command of theoretical predictions of key observables and instrument knowledge must inform each other a robust inference framework is required to compare and combine the wide datasets soon to be available without this interconnected analysis pipeline the richness and complexity of new data will spoil detection prospects relics is the project to lead new cosmic microwave background cmb experiments towards discoveries in particle physics i propose a program built around my expertise in particle cosmology and cmb data analysis that will deliver new and robust limits on neutrino and light relics properties the flagship experiment is the groundbased simons observatory for which i already lead key parts of the analysis relics is timely the analysis pipeline will be immediately applied to fresh data from 2024 the same pipeline will shape the analysis strategies of the two ultimate cmb experiments of which i am a key member of the groundbased cmbs4 and the spaceborne mission litebird my expertise is unique in that embraces understanding of the theory instrument data analysis and highlevel science exploitation through relics i will lead work that will crucially support cosmology towards first discoveries in the neutrino and light relics sector and pave the way to robust exploitation of ultimate surveys
development of a revised plant synthetic biology toolkit to advance crop improvement

agronomy faces significant global challenges such as coping with climate change a need for more sustainable practices and an increasing demand for more food of higher quality due to a growing population addressing them will require the adoption of transformative innovations such as the genetic technologies that underlie plant synthetic biology synbio plant synbio through transgenesis and more recently gene editing allows us to proactively alter plant dna to modify their characteristics and address the aforementioned challenges in addition plant synbio can enhance the production of highvalue or new compounds in plants by molecular farmingsynbio requires the generation of complex dna constructs that comprise several transcriptional units facilitated by the development of modular cloning toolkits and the phytobrick standard syntax a recent agreement of the plant synbio community that systematized the sequence requirements for cloning the aim of replant is to generate a new plant synbio toolkit based on the phytobrick architecture that includes the latest developments in protein production and gene editing techniques the advantages provided by the replant will be demonstrated by two proofofconcept experiments with biotechnological applications enhancing the production of sarscov2 recombinant antibodies in plant leaves and modification of tomato plant architecture in variants of commercial interest this toolkit alongside its dissemination approaches will allow a faster advancement of plant synbio accelerating the development of improved crops to help solve the global challenges of sustainability and food security