Dragon09/odtu_chatbot huggingface dataset:
therapeutic bacteria biohybrids for oncology treatment

therabot pioneers a groundbreaking approach in the fight against cancer through the development of engineered biohybrid agents ibots these ibots represent a significant leap in bacterial cancer therapy bct combining synthetic biology and nanotechnology to encapsulate therapeutic bacteria with protective polymeric coatings this encapsulation aims to enhance the delivery and efficacy of bacteria to colonize tumor tissue drastically reducing the adverse immune responses and systemic toxicity associated with traditional bct therabots innovative strategy focuses on colorectal cancer employing a multifaceted approach that includes the design of advanced intelligent biohybrids by programming ibots for targeted therapeutic action and validating their effectiveness in vivo central to therabots mission is its interdisciplinary and international consortium comprising 12 members from 10 leading academic institutions and 2 smes across europe france spain and sweden and from noneu countries japan argentina chile brazil and thailand this collaboration fosters a unique integration of diverse scientific disciplines including bioengineering immunology material science and oncology promoting the exchange of knowledge techniques and cultural perspectives which is pivotal for addressing the complex challenges of developing a new cancer therapy therabot not only emphasizes the scientific innovation but also prioritizes the training and career development of seconded staff enhancing their research competencies and preparing them for future challenges in diverse fields therabots focus on developing accessible and patientfriendly cancer treatments underscores its alignment with eu priorities in health and innovation by redefining cancer treatment paradigms towards more precise effective and personalized approaches our project aspires to have a lasting impact on society improving patient outcomes and contributing to the global fight against cancer
combinatorially and algebraically decomposing search spaces better worstcase bounds for hard search tasks

search tasks are computational tasks with a curious property while their solutions are easily verifiable when given finding those solutions from scratch appears much more arduous a central algorithmic paradigm to solve such tasks is that of search space decomposition this paradigm solves a search task by breaking it up in subtasks such that a solution to the original problem can be quickly recovered from solutions of the subtasks despite its basic nature and its ubiquitous use it still holds many mysteriesthe mission of coalesce is to develop a broad theory to design and analyze search space decompositions to solve fundamental search tasks as fast as possible in the standard model of worstcase analysis strikingly such a theory has not been developed yet our theory will be a coalescence of two established theories combinatorial search space decompositions have been studied for graph problems in the area of width parameters but only focus on decomposing the input and not the search space algebraic decompositions such as factorizations of matrices and tensors that are of low rank or sparse have been studied in the area of algebraic complexity but only for very few problems and not in combination with search space decompositionsin this proposal i identify concrete research problems from parameterized and finegrained complexity two prominent subfields of theoretical computer science that serve as stepping stones towards a model for search space decompositions beyond input decompositions as well as a theory to analyse their algorithmic power based on combinatorial and algebraic decompositionsnow is the right moment for this project the joint power of combinatorial and algebraic decompositions is still barely understood and not yet fully exploited coalesce will combine these and many more tools in novel ways that transcend existing approaches and bring a rich theory on the search space decomposition methods entirely within reach
drugeluting electrical implant to repair the spinal cord

in neurofibres fetproactive 20172021 we accomplished a major therapeutic advance for spinal cord injury sci by combining biomaterials pharmaceuticals and electrical stimulation into an innovative implant able to promote the closure of the spinal cord gap with axonal regrowth and glial cell migration across large lesions in rodent and porcine models of sci in brief the implant comprised biofunctionalized conducting polymercoated carbon microfibres mfs that promoted aligned neural cell growth across the lesion embedded within a drugeluting hydrogel that filled the tissue defect and reduced fibrosis these intraspinal elements were complemented with electrodes that provided biphasic electrical stimulation es to the lesion and the perilesional tissue thus inducing extensive neural regenerationbuilding on the initial proof of concept achieved in neurofibres trl 3 dreims will mature this novel healthcare technology through trls 45 becoming close to its approval for use in human therapeutics while creating a business plan to support further exploitation steps the inventors of the implant filled a patent application p202230626 on the mentioned results and recently created a spinoff company spinal cord technologies sct sl to pursue the refinement and validation of a successful clinical and commercial medical product dreims builds on those results to consolidate the firstinclass drugeluting electrical implant to repair the spinal cord the implant will refine and integrate three modules namely the microfiberdrugeluting gel bundles mibs from fuhnpaiin sct sl spain spinal electrode arrays seas from alufrimtek germany and a fully implantable electric pulse generator ipg from neurinnov france thus forming a procedure pack according to the european medical device regulation mdr 2017745 addressing regulatory requirements and business development activities will increase the market readiness of the implant
a gathering place to codesign and cocreate adaptation

agora will support the overall objectives of the mission on adaptation to climate change by leveraging and step forwarding bestpractices innovative approaches policy instruments and governance mechanisms to meaningfully and effectively engage communities and regions in climate actions accelerating and upscaling adaptation process for building a climate resilient europe it will promote democracy climate justice gender equality equity and foster adaptive capacity and citizens empowerment to proactively support decisionmaking processesagoras main ambition beyond the state of the art is to promote societal transformational processes in different social economic and political contexts through transdisciplinary tools and approaches citizens civil society organizations academics experts policymakers entrepreneurs and other relevant actors will be engaged in the codesign and cocreation of innovative problem oriented climate adaptation solutions that could be extensively adopted in europe also considering the deep social changes on going and the awareness that no one size fits all solutionspecifically agora will providea package of digital tools and codeveloped frameworks relying on multidirectional communication technologiesinnovative problemoriented climate adaptation solutionsblueprints for effective decision making and collaborative processes that build on the dialogue among stakeholders and on the integration of different types of knowledgea set of pilot regions will constitute the coproduction arena to codesign codevelop and coimplement climate adaptation solutions agora will also develop a roadmap for transformational change and upscale of citizen engagement for transferability of effective policy instruments and for ensuring long term legacy
revealing second messenger functions in bacterial stress response cell differentiation and natural product biosynthesis

sophisticated signalling systems enable bacteria to occupy almost every single niche on our planet in such systems second messengers are crucial information carriers that elicit cellular adaptation to diverse signals current dynamics in signalling research have led to the discovery of an exquisite collection of nucleotides that bacteria use as second messengers including cyclic dimeric adenosine monophosphate cdiamp a unique feature of cdiamp is its essentiality making it an attractive target for antibioticsthe main objective of this proposal is to uncover the full repertoire of cdiamp functions and metabolism in bacteria by using streptomyces as a model streptomyces are our most prolific antibiotic producers and represent an excellent system to study multicellular differentiation they live in soil where they encounter diverse environmental cues that trigger antibiotic production and a complex transition from multicellular filaments to spores cdiamp enables streptomyces to survive osmotic stress caused by rainfall and drought but interferes with development how cdiamp affects differentiation and how these bacteria adapt to stress signalled by cdiamp is unknownhere we propose that bacteria use a novel transmembrane signalling pathway to remodel their cell wall for surviving stress mediated by cdiamp we will challenge the current view in the field by showing that the set of enzymes involved in cdiamp dynamics is larger than it is currently believed and we will identify new cdiamp effectors finally we will explore the potential of cdiamp for manipulation of natural product biosynthesis and address the function of a linear diamp molecule that is new to signalling research our proposed research will not only lead to the discovery of fundamental new principles in bacterial signalling and differentiation but might also identify new cell wall associated targets for drug design and tools for triggering antibiotic biosynthesis
a precipitationshed approach to changing extremes

characterizing the frequency of future precipitation extremes is a fundamental task in order to understand and mitigate their effects under future climate conditions however predicting these changes is a challenging task as intense rainfall is poorly represented in climate models and extrapolations based on historical data are highly uncertain the objective of the pace project is bridging this disconnection by developing an innovative physicallyinformed statistical model for rainfall extremes the proposed methodology explicitly accounts for the interannual variability of atmospheric moisture fluxes and their future predicted changes pace will achieve this objective by using an innovative precipitationshed perspective precipitationsheds the regions of earth from which most precipitable water originates before reaching a target site will be computed using a moisture tracking technique by including in the statistical representation of rainfall extreme key physical information integrated over a precipitationshed pace will provide a novel representation of how dynamic and thermodynamic changing conditions in upwind areas affect the frequency and probability distribution of downwind precipitation by learning rainfall statistical properties from historical data and relying on climate model predictions only for large scale climate features the pace action will improve probabilistic rainfall predictions under future climate scenarios the candidate recently graduated from duke university durham nc will join the host at tu delft delft the netherlands to achieve this research objective and to continue his postgraduate professional development aimed at creating an independent research program in hydroclimatology
lets care building safe and caring schools to foster educational inclusion and school achievement

secure attachment relationships play an important protective role against the intergenerational transmission of social exclusion not only at early stages but at all school levels lets care aims to comprehensively understand and improve the caring dimension of educational inclusion and school success the project main objective is to identify determinants affecting student security as a root cause of underachievement disengagement and school dropout at 4 different ecological levels individual relational community and political lets care will create a theoretical and practical framework to foster safe learning safe teaching safe schools and safe education in each level as an approach to break the chain of transgenerational transmission of educational and social exclusion this approach will generate lower rates of school failure poor learning outcomes and early school leaving the main proposal breakthrough is based on considering a relational response to educational exclusion and inequality resulting in a model for understanding the importance of security to address underachievement and early drop out and a relational approach to inclusive practices at school that will be translated into tools recommendations and guidelines for action from ecec to secondary and second chance schools a multilevel multistage and intersectional research exploring different european educational contexts will be implemented including120 schools 18000 students and 2400 teachers from 6 european countries in 4 schools stages with special attention to multidisadvantaged learners lets care supported by a expert consortium will implement a holistic methodological approach including cocreation mechanisms and will translate research findings into political approach through formulation of novel evidencebased policy recommendations raising awareness on safecaring schools combating social exclusion of disadvantaged learners
democratic elite perceptions of economic and monetary union

demu provides highly innovative research on a crucial challenge for democracy in the eu the legitimacy of governance in the economic and monetary union emu it focuses on conflicts within everyday democratic practices of domestic policy elites participating in the budgetary exercise of the european semester identifying a substantial gap in the literature so far developing an innovative interdisciplinary approach and using a mixed methods design analysing four cases france germany the netherlands and italy demu contributes a to our understanding of the variation of legitimacy conflicts in the emu and jumpstarts b a debate about contextualised democracy standards for eu decisionmaking the project combines ethnographic and reflexive quantitative methods with conceptual history demu commits to data sustainability in qualitative research by providing a report on the research process in order to make the qualitative data fully reusable by qualitative scholars demu is led by dr anja thomas at the fulda university of applied sciences under the supervision of prof dr claudia wiesner a renowned scholar for conceptual history of the european union two secondments european university institute and centre for research in economics and statistics complement the fellowship to allow specific methods and dissemination training supervision will be closely coordinated a detailed work and dissemination plan ensure progress and sustainable impact of the project the msca will expand dr anja thomas current work on parliaments and make it a beneficial preparation for a larger grant proposal to allow her to become a leader in her field fulda university of applied sciences commits to fully support the fellow with administrative and additional financial resources the researcher will contribute to the phd training at her host institution dr anja thomas has substantial experience in research and teaching at leading universities notably in france and the uk
deuterium labeling of glucose improves magnetic resonance imaging sensitivity to cancer metabolism

the targeted scientific breakthrough of glucoscan is the development and clinical evaluation of a disruptive wholebody molecular imaging concept for cancer assessment the only currently established wholebody molecular imaging device is positron emission tomography pet glucose glcsensitive pet is widely used in cancer diagnosis and treatment assessment but has several major limitations pet involves harmful ionizing radiation is expensive not widely available and cannot differentiate between cancerspecific and normal cellular glucose uptake these limitations prohibit an even more widespread use of pet eg for screening we propose a new magnetic resonance imaging mri concept wholebody deuterium metabolic imaging dmi that will overcome these limitationsdeuteration is a simple chemical procedure with which it is possible to artificially label a broad range of molecules with an equally broad range of potential applications eg targeting glc metabolism in cancer after ingestion this labeled glc is metabolized in cells and the label is transferred to all metabolic products which can be tracked by dmibuilding on our recent preliminary results in nature biomed we propose a combination of novel mri hardware dynamic spectroscopic data sampling deep learning algorithms and a clinical validation to answer the following three research questions in a 5year projecti is dmi a viable alternative for wholebody cancer assessmentii how is dmi positioned compared to glcsensitive petiii can dmi be performed on widely available mri systems and simultaneous with standard mriglucoscan will fill a gap in current medical imaging by offering an alternative for wholebody pet examinations and potentially even for screening of high risk populations ultimately it will pave the way for a new generation of mr scanners with allinone wholebody imaging capability that would capture morphologic and molecular information simultaneously
merging lowvalent bi redox catalysis with electrochemistry for the formation of csp3c bonds

the proposed work involves merging lowvalent bismuth catalysis with electrochemistry to unlock eminently sustainable methods for cc bond formation the research outlined herein would constitute the first systematic foray into electrocatalytic organobismuth manifolds for the synthesis of organic moleculeswelldefined monomeric bii pincer complexes have recently been used to activate redoxactive esters and alkyl halides via 1electron and 2electron pathways respectively in the first section we propose a systematic electrochemical characterization of several ncnbiiii pincer complexes with particular emphasis on identifying the reversibility and potential of distinct redox states accessible by each complex the cathodic reduction of biiii species to their bii counterparts will also be performed in the presence of alkyl electrophiles to afford biiiialkyl species the insights obtained from these foundational studies will be applied in the context of developing electrocatalytic manifolds for the csp3 carboxylation and csp3csp3 coupling reactions two transformations that remain challenging even in the context of transition metal catalysis
womens substantive representation and gender mainstreaming in the eu pandemic recovery

recovergeu presents an innovative gendered perspective on eu crisis politics and policies integrating theoretical and methodological approaches from political economy eu gender and policy analysis the project aims to understand how the effectiveness of gender mainstreaming within the multilevel governance framework of the eu is moderated domestically by womens representation the project addresses whether womens substantive representation extends beyond parliamentary debates to fiscal policy outcomes in the case of the covid19 crisis and the national recovery and response plans recovergeu provides a timely gendered assessment of the ongoing flagship eu response to the pandemic and offers insights into the drivers of heterogeneous gender mainstreaming in the recovery enriching the debate on the future of eu economic governance and gender equality policies the project is methodologically innovative as it improves textasdata approaches for classifying gendersensitive policyrelevant content and extends civically engaged research methodologies to the multilevel multilingual and crosscountry context of eu politics and policiesthe host institution and supervisor offer the fellow an ideal interdisciplinary and policyoriented environment at the frontier of research on eu crisis responses and gender equality policies the fellow will receive training in cuttingedge computational qualitative and gendered policy methodologies additionally she will gain unparalleled access to practitioners and an extensive network of partner institutions in all fieldwork cities and with renowned gender research centers at the same time eui offers crucial research support and expertise in grant development and project management
reversible heterolytic mechanophores for dynamic bulk materials

stimuliresponsive polymers adapt their properties in response to external cues engineering such smart behaviour in artificial systems by molecular design is an exciting fundamental challenge that can lead to technological breakthroughs most stimuliresponsive polymers rely on heat and light to trigger changes in materials properties in a predictable fashion however limitations intrinsic to these stimuli highlight the necessity of alternative strategies naturally evolved systems widely exploit mechanical stimulation to regulate their functions but recreating such concept in artificial materials has proven extremely challenging thus farrehuse proposes a radically new approach that focuses on the application of mechanical force to induce changes in bulk materials properties isothermally and reversibly the research project aims at pushing the frontiers of covalent mechanochemistry through the development of reversible heterolytic mechanophores molecular platforms that dynamically generate and recombine two oppositely charged macromolecular fragments upon mechanical stimulation these new motifs will enable dynamic chemistries involving organic ionic species in solidstate systems in two different types of advanced bulk materials combining reversible mechanochemistry and dynamic covalent chemistry will lead to dynamic covalent polymers displaying selective mechanoresponsiveness this concept will be leveraged to create recyclable materials the reversible generation of charges from the heterolytic scission will enable to modulate hydrophilicityhydrophobicity dynamically such principles will be explored to set the groundwork for mechanoresponsive atmospheric water harvesters this interdisciplinary research project will advance our understanding of mechanochemistry and more importantly will usher new avenues for its productive and repeatable use in adaptive materials