Dragon09/odtu_chatbot huggingface dataset:
integrated ai diagnostics in breast cancer

in eu27 it is estimated that 355000 were diagnosed with breast cancer bc in 2020 initiatives to reduce this burden in europe involve early and precise diagnosis in the standardofcare management to decrease unnecessary or insufficient treatment notably precision medicine in bc is still in its infancy and is becoming even more critical with neoadjuvant chemotherapy nac a standard of care treatment protocol in her2positive and triple negative subtypes recently the use of digital diagnostics with ai is gaining momentum since it shows great promise towards accelerating personalized bc patients pre and postnac predictions while ai paves the way to next generation diagnostics this has yet from been translated as a it mostly operates in single data modalities that fail to capture the complex disease alterations b integrated ai usually suffers from data incompleteness usually leading to models trained with limited data that fail to generalize to new patients andor that are not able to integrate partially observed multimodal information from the whole population granite focuses to address these unmet needs and goes beyond the stateoftheart fusing the most relevant standard of care data radiology pathology clinical demographic leveraging novel ai and radiomics algorithms granite will deploy pretrained deep learning models that will be finetuned technically validated and clinically evaluated against pertinent clinical data of nonmetastatic bc cases from the bank of cyprus oncology centre cyprus we will engage with the ai4hi project to transcend futureai guidelines fairness universality traceability usability robustness and explainability futureaieu into granite towards generating realworld evidence and making our ai technology clinically sound ethically aware and technically applicable and promoting ai trust and acceptance in bc management
transcatheter ventricular repair device for treatment of heart failure patients

heart failure hf represents a major public health concern affecting around 13m people worldwide a major risk factor for hf is a myocardial infarction which causes ventricular remodelling during which the ventricle enlarges making the heart even less effective at pumping blood and results in displacement of the papillary muscle progressive papillary muscle displacement leads to severe functional mitral regurgitation in about 20 of the patients the only ones currently receiving treatment because of the severity of the condition the remaining 80 of patients dont experience severe fmr and are not considered for surgery they will continue to suffer and likely die since there is no therapeutic option available cardiac success develops the vsling system a transcatheter ventricular repair device to improve cardiac function in hf patients the objectives of the project are to finalize product optimization complete vv and preclinical testing and perform the fih study
spindependent string fragmentation

the fragmentation process is one of the most intriguing and poorly understood phenomenon of quantum chromodynamics qcd it belongs to the nonperturbative domain of qcd and is usually described by processindependent fragmentation functions ffs traditionally nonperturbative effects in the fragmentation process related to the quarkspin degree of freedom have been neglected and only recently their importance has been brought to light by the discovery of the collins effect in transversely polarized quark jets such effect described by a new spindependent ff is a polarimeter for the transverse polarization of the quark initiating the jet and is presently used to access the partonic structure of nucleons this project is dedicated to the study of the spindependence of the fragmentation process in the framework of the recent string3p0 model an extension of the lund model reproducing the collins effect and other effects observed in fragmentation to the development of the model and to its implementation in the pythia8 event generator for the simulation of the electronpositron annihilation process in hadrons the end goal is the introduction of spineffects in the polarized fragmentation of arbitrary string configurations originated from the parton showering process the implementation of the string3p0 model in the pythia8 generator will be achieved by extending the stringspinner package which will be used for the phenomenological description of the spindependent observables measured in electronpositron annihilation the proposed project will bring to new insights on the spindependence of the fragmentation process and to a practical open access mc event generator program acting as a theoretical laboratory for the study of this process on a longer term the project is expected to lay the foundation for the systematic introduction of spin effects in the pythia8 generator for other collision processes as well
extreme time and angular resolution in the optical with cherenkov telescopes

the universe in the visible wavelength remains largely unexplored in the subsecond time regime and submilliarcsecond scale primarily due to instrumental limitations overcoming these impediments would bring a breakthrough in our knowledge of stellar physics evolution and modelling by imaging the stars and their surroundings as well as unravel the history of the solar systemmicrostars will demonstrate the viability of a costeffective and novel solution to enhance the capabilities of imaging atmospheric cherenkov telescopes iacts to perform ultrafast optical measurements such an upgrade allows two novel applications of these telescopes in the visible range their use as stellar intensity interferometers and as hightimeresolution fast highprecision photometersmicrostars will allow to expand the limiting time and angular resolution of current optical observatories by at least an order of magnitude by upgrading the capabilities of nextgeneration iacts microstars has the potential of creating a host of scientific breakthroughs answering fundamental questions regarding stellar physics magnetic activity and modelling exoplanet properties and the solar system planetary formation the interdisciplinary and fieldtransforming nature of microstars merging astroparticle physics instrumentation with optical astronomy will extend the scientific life of current iact experiments and greatly expand the scientific impact of the next generation the cherenkov telescope array bringing this proposal to life is only possible with an ambitious funding scheme willing to finance the major equipment needed and support a research team with the required multidisciplinary skills to expand the state of the art with novel instrumentation and methodologies
air isothermal compression technology for long term energy storage

recognizing that current storage solutions are unable to stabilize enough the intermintent renewable energy production new long term energy storage solutions are becoming mandatorycurrent longterm energy storage is mainly provided by pumpedstorage hydroelectricity psh compressed air energy storage caes has appeared for decades as a credible alternative but its poor energy efficiency the need of fossil fuels and the use of existing underground cavities as storage reservoirs have limited its development variations to caes have shown low efficiency losing a big percentage of energy as heat and mechanical losses since the 2010s there is a strong revival of scientific and industrial interest on caes led by china and the european union eu for the eu leading the new generation of highefficient low climateimpact and longterm energy storage research is key to increase its energy independencyin this context the main objective of air4nrg is the development of an innovative efficient over 70 rte longterm and sustainable caes prototype which can enhance renewable energy availability and offers robustness and safety while increasing cost effectiveness and improving the environmental footprint at the same time it will promote innovation and competitiveness in the european energy storage industry while prioritizing the principles of circular economy and environmental sustainability another key factor of the solution is the integrability to the electrical grid system and their intelligent ems which will be proven by the end of the project through end user integration activities trl5 the project will result in a plug and play prototype fitting into a standard 40ft container with an over tenhours storage duration the developed system is a rare materialfree solution with simple industrial infrastructure needs allowing its full development within the eu strengthening europes position in the energy storage system sector
dynamic nanocluster biomolecule interfaces

metal nanoclusters mnc are atomically precise metal nanoparticles with definite mass structure and chemical composition their metal core of 13 nm in diameter exhibits quantized electronic structure and they are chemically stabilized by a molecular surface layer which is modifiable for functionalization and optimized biocompatibility making them promising materials for novel applications in bioimaging biosensing and nanomedicine as fluorescent markers sensors and targeting drug carriers paving way to personalized medicine and therapeutics their ultrasmall size makes them amenable to atomscale modeling which may greatly help experimental efforts to design their properties for applications however consolidated simulation strategies capable of dealing with phenomena over a wide range of dynamical processes at the nanocluster biomolecule interfaces are missing to address this need dynanoint will develop new multiscale simulation strategies assessing critically graph theory and machine learning ml methods as potential accelerators for discovery of structurefunction relationships combined with traditional electronic structure methods and forcefield based dynamical simulations the methodology is applied to i weak chemical interactions between mncs and proteins ii electronic excitations and chargetransfer interactions at the mnc environment interface and iii chiral mnc environment interfaces pis extensive collaboration network to three key experiments around the world ensures efficient spread of impact of this theoreticalcomputational project to reallife applications the project has a broad impact on computational nanoscience since the developed opensource software will give new tools to study structurefunction relations in lowdimensional lowsymmetry nanostructures for which combination of robust transferable and interpretable ml models with traditional simulations methods poses a significant contemporary challenge
overcoming monocyte complexity in pulmonary fibrosis progression from onset to endstage

progressive pulmonary fibrosis pf is a debilitating and incurable disease scaring of the lung leads to respiratory failure and 50 of patients die 35 years after diagnosis our understanding of the pathophysiology of pf is unfortunately limited to established and advanced stages when the extensive lung scaring is irreversible omega is designed to explore new mechanisms underlying pf progression from early to advanced disease and propose therapies that timely target the disease prior to becoming permanent two lines of evidence are at the core of omega first i was among the first to show that circulating monocytes are strongly linked to pf pathology which subtypes are important and what roles they play in pf etiology however is still unknown second interstitial lung abnormalities or ila are the only detectable features characterizing earlier stages of pf and can be identified in people without clinical suspicion of disease studying ila provides the unique opportunity to identify early targets that would prevent progression to pf omega will first provide a detailed phenotype definition of human monocyte subtypes from early to advanced pf second it will probe mechanistically how and where the monocytes acquire a pathogenic phenotype as they journey from the bone marrow to the blood and differentiate in the fibrotic lung i will use human and mouse material and stateoftheart methodology to answer these questions my current standing ensures direct and ample access to patient samples clinical data multidisciplinary interactions and a team of consultantscollaborators that will make possible identifying how monocytes and their progenitors are involved in the progression of pf and what pathways we can target as early as disease starts and as early as monocytes egress the bone marrow to end the progression of this deadly disease
plasmonic photothermocatalyzed composite membranes for remediation of persistent pollutants in water

water contaminants of emerging concern cec are pressing issues due to their high persistence and deep impact on ecosystems amongst them antibiotics contribute indelibly to the proliferation of 2nd generation cecs such as antibioticresistant bacteria and resistance genes merlin project pursues developing an integral and green solution for the abatement of cecs water pollution by applying forefront photothermocatalytic membranes thus photocatalysis arises as one of the greener and more promising technologies for cecs mineralization however its success is conditional on the use of semiconductors scs with adhoc properties to work under solar irradiation merlin will finely tune the bandedge potentials of novel photoactive scs in order to expand their solar light harvesting capacity and efficiency in addition the cooperative effects of dual photo and thermal catalysts will be explored by engineering local thermal energy hotspots into scs photocatalyst for instance the thermalassisted photodegradation of cecs is foreseen to overcome the performance of classic photocatalytic systemsso merlin aims by engineering the band gap of nanostructured sno2 and cuo scs to confer them a plasmonic response making them autarchic photo thermo catalyst materials pptm able to drive an accelerated cecs mineralization in addition merlin proposes developing forefront photothermocatalytic nanocomposite membranes through the immobilization of pptm into 3dpolymeric microstructured membranes via 3d printing techniques these composites pursue to immobilize cecs into the polymeric scaffold while pptm nanotechnology faces their degradation and of their subproducts until their complete mineralization finally merlin will run under the circular economy concept where the green membranes will be developed for their recovery and reusability considering the full assessment of their ecotoxicity
flexible inteligent nearfield sensing skins

the fitness project will realize flexible smart skins able to provide a noncontact sense of touch the envisioned smart skins will operate at microwave frequencies and the same device will also allow farfield communication the key technology enabling these functionalities is that of metasurfaces ie structured surfaces that have unusual properties at some frequencies in this case they convey and manipulate surface waves which also can be turned into radiating leaky waves for farfield communications the research follows a holistic and multidisciplinary concept targeting thin smart skins the fitness project encompasses the synthesis of new lowloss flexible microwave substrates research on the embedded electronics the analysis and design of metasurfaces on curved structures and data analysis the first demonstrator will be realized in the field of robotics while later applications are envisioned in the medical area therefore fitness will integrate ultralow power operation from the beginning the devices will essentially work through the measurement of the transmittance between a limited number of ports sparse electronics through surface waves following the shape of the smart skin which is wrapped around the robot or the body the workpackages follow the main challenges toward the new technology sparse curved integrated and flexible metasurfaces one of the main societal outputs will consist of a more harmonious cooperation between robots and humans through the constant probing of their respective nearfield environmentsthis ambitious 48months 36 meuros action gathers complementary key european experts from 4 eu countries covering electromagnetics electronics materials robotics thermal aspects but also the necessary skills for appropriate management communication and exploitation 3 universities 5 research teams 2 smes and 2 research centers
qcircle center of excellence accelerating quantum impact on sustainability

qcircles center of excellence coe vision is to accelerate the adoption of emerging quantum technologies enhancing their broad and deep potential benefits the activity of the coe will move vertically along the four basic pillars of quantum technology sensing computing algorithmsoptimization and communications and horizontally facing missions where their impact on sustainability is expected to make a difference such as the efficient distribution of energy and monitoring the high precision sensing and modelling of the evolution of climate change indicators the development of co2neutral transports and industriesagriculture and early diagnosis and personalized treatments rare diseases neurological conditions or cancer qcircle coe will be settled in the canary islands outermost spanish region and emerges to become a triplecrown winner in quantum science becoming a reference as a quantum educator a quantum research hub and a quantum innovation hub to make sure quantum technology reaches society and markets for this qcircle coe will mobilize the canarian ri ecosystem and will establish solid longterm highlevel research knowledgetransfer and innovation partnerships with the counterparts advanced partners ap from ulm university reference centre for quantum sensing and quantum optics germany quantum technologies platform at research council reference centre for quantum algorithms communications spain the institute for quantum optics and quantum information iqoqi of the austrian academy of sciences austria and quantum technology hub at university of birmingham reference centre for quantum metrology and applicationsthe coe will attract international expertise and investment and will act as a springboard for exporting canarianspanishgermanaustrianunited kingdom knowledge and hightech quantumrelated solutions globally in the long run the coe will have full autonomy and financial sustainability
excellence initiative for nutrifoodbased theranostics for healthy european society

transformations are needed throughout europe including a widening country serbia especially in terms of institutional reforms and upskilling with this in mind we created the excellence initiative of sciencetech team for european innovations einstein which consists of nine institutions from serbia austria the netherlands and denmark the einstein will use a trans and multidisciplinary approach to increase knowledge and technologies in the organic production of crops with improved nutritional and bioactive properties nutricrops for human nutrition which will be also used as a raw material for manufacturing nutrifoodbased sensors and microfluidic chips that will have a dual function therapeutic and diagnostic the transformation model that will reform the outdated education system in serbia is proposed successfully implemented transformation in serbia through this project will spread like a positive tide of change in education research and innovation system throughout the whole western balkans region this will be done within the following work packages wp1 transformation of education ecosystemwp2 creating and testing ecofriendly sustainable nutrifoodwp3 development of nutrifood and nutriwastebased theranostic deviceswp4 upskilling and reskilling of workforcewp5 communication dissemination and exploitation phase 1wp6 communication dissemination and exploitation phase 2wp7 project management and coordination phase 1wp8 project management and coordination phase 2farreaching goal is to transform the university of novi sad serbia to contribute to regional development promote business growth by contributing to regional human capital development and improve social equity through regeneration and cultural development the establishment of the alliance with topclass universities from austria the netherlands and denmark will be a key momentum for achieving this longterm strategic direction
transformative food value systems reshaping resilient urban landscapes

redesign will support the transformation of local urban food systems by creating food value systems fvs fvss aim to strengthen urban resilience through foodled green urban and periurban infrastructure enhancement foster participation in the food system of local communities with a particular focus on vulnerable groups contribute to the quality and beauty of living places and mitigate climate change through the integration of urban agriculture with the built environment the fvss will operate through the development and application of a learning loop methodology grounded on neb values to accelerate innovation in all the steps of the food system including production consumption exchange and disposal and expand beyond the notion of food chain to integrate the cultural social and political dimensions of the transformation the network will consist of three main groups of actors observation cases implementation cases and a board of cities observation cases exemplify consolidated best practices in the pilots the redesign food value networks will be set up and implemented with the involvement of local stakeholders particularly vulnerable groups each implementation case will have a specific focus on one of the domains of the urban food system nutrient recovery and food production the setting up of a multifunctional food lab and food policy councils the implementation cases will become living labs through which the innovation in local food value networks will scale up at two levels the metropolitan one contaminating nearby districts through training and transfer and the international one enhancing the observation cases closing the learning loop and informing the board of cities for policy innovation and learning results will include regenerated neighborhoods in the implementation cases the setting of three living labs steering the food value networks a learning loop methodology all scalable and replicable in other contexts