Dragon09/odtu_chatbot huggingface dataset:
transcription factors and regulation of aqp expression in maize stomatal guard cells and subsidiary cells

the stomata are openings formed on the epidermis formed by two guard cells gc surrounded by subsidiary cells sc allowing gaseous exchange for photosynthesis at the expense of water via transpiration stomata are tightly regulated by the influx and efflux of water and small solutes across gc or sc membranes the diffusion of these solutes and water through the membranes can be facilitated by aquaporins aqps while there is insufficient knowledge on the precise role of aqps in stomata specific microdissection of the mechanism of aqp action in gcs and scs affecting stomata is further limited the superiority of grass stomata owing to their quick response make them apt for studying the role of aqps in stomatal response especially under abiotic stress condition since climate change has made crops worldwide extremely vulnerable in this regard maize is an appropriate grass crop to use as a model because of its economic importance the overall goal of this project is to study the role of different aqps and their transcriptional regulation in stomatal complexes that can be used to produce stressresilient crops we will be using transactivation assays protoplast engineering maize suspension cells and crisprcas to achieve the objectives the mechanisms uncovered here can be monumental to extrapolate the grass stress resilience mechanisms into other vital crops this project will help add the experience required for my goal of being an independent group leader i will gain from the scientific environment and the infrastructure and support system at libstuclouvain as well as from the vast experience of prof chaumont in research and project management in turn the host will benefit from the technical skills and creativity that i can offer
exploring the therapeutic potential of perinatal cell secretomes

over the past two decades cells isolated from human perinatal or birthassociated tissues amniotic membrane umbilical cord tissue and cells from amniotic fluid have been shown to provide tremendous proregenerative activities amongst others the application of these cells or of components of their secretome including extracellular vesicles evs have been found to improve myocardial infarction mi ischemic stroke is and multiple sclerosis ms symptoms in various animal models currently cellfree therapies represent a frontier for innovation in regenerative medicine for clinical unmet needs however very few scientists are trained for their clinical translation exploring the therapeutic potential of perinatal cell secretomes secret sets out with the ambition to train 10 doctoral candidates dcs to disentangle the inherent therapeutic potential of perinatal cell secretomes either as a whole or as fractionated small evs in order to possibile translate novel biologics into the clinic their specific focus will be the characterisation the delivery and the preclinical evaluation of these perinatal secretomes as an innovative therapeutic approaches for mi is and ms to achieve this goal universit cattolica del sacro cuore prof ornella parolini italy unites internationallyrenowned academic and nonacademic institutions from italy the netherlands germany belgium portugal and switzerland to deliver an interdisciplinary programme that goes beyond current stateoftheart research in next generation medicinal product development and validation these include the development and use of ipscderived organoids and organonachip models to identify the most efficient perinatal cell secretome in terms of immunomodulation angiogenesis antifibrotic cardioprotective and neurotrophic properties as well as the assessment of their in vivo cardiac reparative and neuroregenerative potential using novel delivery methods
lumen empowering the blind

there are over 40 m blind and over 238 m visually impaired people in the world struggling with everyday mobility who cant be employed or educated because of it while technology advanced and solutions appeared for multiple challenges that they face the area of mobility has not seen much change most of the technological solutions available are expensive they dont help to navigate and work only with some eyesight lumen has tackled these problems and created a solution which has a system able to understand the world like a vision capable individual the device understands the environment computes navigation paths for the users and transmits information through the sound and impulses on the forehead moreover it is affordable and easy to use lumen already made an incredible progress with its patents research and product iterations now the team is applying for the eic accelerator to finalise the product pilot it and enter the market thus requests eur 55 m of funding
biocarbon based polymers for sustainable material development

dcarbonizes approach targets biocarbon recycling into valuable starting materials for the chemicalpolymer industries and will primarily provide innovative lowcarb catalysis solutions the use of biocarbon is advantageous in many respects as it is renewable generally abundant and nontoxic and it represents easytohandle carbon reagents even on larger scale despite the lack of universal catalytic strategies available for biocarbon valorization into monomers and polymers recent advances in catalysis science have demonstrated the engineering and use of new promising metal and organocatalysts with high potential to overcome these limitations thereby creating the necessary feasibility to transform biocarbon into 1 fine chemicals such as carbonates carbamates carboxylic acids and esters 2 pharmaceutical synthons and 3 biomassco2based polymers thus catalysis has already been shown to be a useful technology for biocarbon valorization but has been rarely used in the wider context of new and functional biocarbon based monomerpolymer development the use of the latter helps to shape the future of functionalized polyesterscarbonatesamides and their subsequent utilization in novel tailormade and commercially relevant materials furthermore this project will also explore depolymerization pathways to recycle the synthesized polymers obtaining new monomers andor other addedvalue molecules that could reenter the loop and be used in new polymers and materials the network will recruit 12 doctoral candidates who will be awarded double doctoral degrees by two universities in two different countries at the end of the training program dcarbonize brings together leading higheducation institutions research centers and companies to form an innovation community able to offer excellent research and training both in rd and entrepreneurship
organic upconversion device for swir imaging

shortwave infrared swir imaging is a powerful tool to access and visualize the composition of biomaterials contactfree and in real time it can be used for example for invivo deeptissue bioimaging as well as for the inspection and quality assurance of manufacturing processes including agriculture pharmaceutics chemicals photovoltaics wafers metals and glasses the global swir market is estimated to 213 million usd for 2022 and predicted to increase by 72 until 2028 however the complex and costly manufacturing of commercial swir imaging prohibits consumers and lowend applications from benefiting from its vast application potential within orgup we propose organic upconversion devices as an attractive lowcost alternative they convert the invisible infrared image into a visible image being then captured by a lowcost commercial camera or sensor however so far such devices have failed to provide the relevant swir sensitivity above 1100nm ie the silicon cutoff the goal of orgup is to develop and showcase for the first time highquality organic swir imaging with a sensitivity up to 1500nm and an upconversion yield of 30 at a low cost while avoiding the use of toxic elements two industrially relevant demonstrators will prove reliable and durable mono and multispectral vision at high resolution and contrast we will combine inhouse recently developed ultralow gap organic semiconductors with unique knowhow in organic nearinfrared optoelectronics and stacked stateoftheart organic light emitting diodes selectivity for specific swir wavelengths will be achieved by embedding the organic stack into optically amplifying and spectrally selective microcavity structures as research and development of the proposed type of organic upconversion devices is relatively new yet with confirmed interest of market leaders for optical solutions we expect to create strategic ip and develop a path to marketing and commercialisation
unleashing cellulose potential laserdriven structural modulation

lasercell envisions an innovative approach to reshape and rearrange cellulose at the molecular level by disrupting cohesive interactions through resonant excitation of specific bonds it will revolutionize the field of biopolymer processing beyond cellulose and yield fundamental insights into supramolecular structure and dynamics in biomaterials although cellulose is biodegradable and mechanically strong it cannot be processed by conventional thermoplastic polymer methods which limits its use as highvolume material cellulose decomposes before it melts because of cooperative intermolecular hydrogen bonding and hydrophobic interactions to plasticise cellulose i propose to disrupt these intermolecular bonds with photon energy delivered by infrared ir laserpulses employing wavelengths matching specific vibrational modes the photon energy will be resonantly absorbed thus effectively plasticising cellulose i envision that the rapid energy dissipation in short pulses will deliver enough peak power to disrupt the intermolecular bonds yet avoiding thermal damage i plan to systematically investigate how laser parameters influence the supramolecular structure of cellulose and establish analytical tools to characterize its structural transitions under mechanical load additionally to allow processability in different setups i aim to prolong the time window of plasticization and adjust the flowability by using the laser irradiation in synergy with the hydrogen disrupting molecules as a proof of concept i will implement this novel photoplasticization technique into a cellulose fibre spinning process and posttreatment to modulate the cellulose fibre crystallinity i have worked for 10 years on cellulosebased materials and have a strong background in fibre spinning and material science my research group will engage 1 phd student and 2 postdocs with background in polymer science and laser physics and technology
african literary metadata

recent years have seen something of a renaissance in african literature with african novelists becoming global bestsellers and achieving the worlds highest literary accolades but published novels are restrictively expensive in africa itself and the novel form is illsuited to african everyday life where people are more likely to spend their leisure time engaging with informal ephemeral and notforprofit literary and oratory cultural forms such as spokenword poetry street theatre and a variety of online genres these informal african literatures are rarely catalogued and therefore exist outside of any structured metadata system the consequence is that formally published english and french african novels are hypervisible globally while the rich literary and oratory cultures of the continent itself are caught in a perpetual state of structural ephemerality the almeda project addresses this problem in three ways first by providing the first history of literary metadata on the african continent the project will provide a diachronic understanding of how colonial cataloguing systems came to construct the idea of the literary work as bookbased and thus dismissive of africas oral cultures secondly almeda aims to develop and publish a metadata scheme specifically designed for these informal literary materials this scheme will be multilingual which will enable a unique descriptive model that allows africanlanguage genres to inhabit their own categories rather than having to be forced into european literary ontologies thirdly the project will develop a linked open metadata repository populated via an interface that allows nonspecialist entry of metadata on literary materials by creating and linking metadata on this body of work this repository will constitute a major intervention in african literature by making these literatures searchable and their records enduring thereby opening up entirely new possibilities for scholarship
unraveling amocco2 feedbacks during the warmerthanpresent last interglacial

the world ocean currently absorbs about 30 of anthropogenic carbon dioxide co2 emissions and is therefore an important source of solutions to fight the climate crisis however the development of oceanbased mitigation strategies requires improved representation of climate processes in earth system models in particular modelling the effects of atlantic meridional overturning circulation amoc weakening on the oceans ability to absorb co2 remains a challenge primarily due to a lack of understanding of climate feedback mechanisms this project draws on highresolution paleoarchives from the north atlantic and a novel combination of geochemical tracers to determine how the amoc varied during the last interglacial period 129 to 115 thousand years ago which is considered the best historic analog of the global climate state projected for the end of this century the project will not only provide crucial constraints on magnitude of natural amoc variability but will allow for the first time a systematic investigation of amocco2 feedbacks in a warm climate helping quantify the mechanisms that influence the oceans effectiveness in sequestering co2 from the atmosphere the results will move us forward in unraveling the oceanclimate nexus and help reduce uncertainties in climate projections which will benefit the intergovernmental panel on climate change ipcc the multifaceted public engagement activities will maximize the projects contribution to the climate emergency and daily climate action contributing to the eu adaptation strategy the eu green deal and the un sustainable development goals
mechanisms of liver regeneration and disease across scales from molecules to cells and tissue

despite recent advances the principles that regulate liver regeneration and how their deregulation leads to disease remain largely unknown the main goal of this application is to uncover molecular and cellular principles that govern liver regeneration and disease and exploit this knowledge to develop more complex multicellular organoid systems capable of reconstructing liver tissue in a dish we will adopt a multiscale from molecule to tissue and multidisciplinary approach addressing the interplay between cellintrinsic and cellextrinsic mechanisms in damage paradigms that result in repair vs diseasein aim 1 we will identify the genomic loci eg transcription factors signalling pathways or epigenetic regulators involved in regeneration and disease to gain a systemslevel understanding of the gene regulatory mechanisms driving liver regeneration and disease in aim 2 we will investigate the biochemical signals mediated through cellcell interactions between ductal cells and mesenchymal to gain mechanistic understanding on how epithelial mesenchymal cellular interactions regulate regeneration and their role in disease particularly fibrosisin aim 3 we will build complex multicellular organoids to reconstruct the liver lobule cellular interactions and architecturean indepth understanding of the molecular and cellular mechanisms driving tissue regeneration and their deregulation in disease holds the potential to uncover new principles of liver biology the generation of complex multicellular organoids that recapitulate liver cellular interactions and architecture will provide valuable tools for future mechanistic studies aiming at investigating molecular and cellular principles of tissue maintenance repair and disease transferring these to human tissues will facilitate future studies addressing the longstanding question as to which principles of repair are conserved in humans and which are human specific
breeding european legumes for increased sustainability

the aim of belis is i to increase the competitiveness of the eu and associated countries legume breeding industry by improving the methodologies and the governance structures of the breeding sector ii to design conditions that allow an efficient delivery of the achieved genetic progress to the breeders and seed industry and to the other actors registration offices extension services feed and food industry farmers the project will focus on seven forage crops and seven grain crop that are currently grown to produce feed for ruminants cattle sheep goat and monogastric animals pig poultry food as is or after processing or to deliver ecosystem services belis has three main objectives 1 to develop tools and methodologies for costeffective breeding programmes and deliver proofs of concept with and for breeders 2 to facilitate the economic and regulatory environment variety registration variety recommendation and business models 3 to implement an efficient ambitious and durable transfer of innovation through the belis platform that includes a network of breeders and actors from scientific research extension services and seed food and feed industries as well as a training portfolio by enabling the creation of improved varieties in many species adapted to different areas and uses in europe this project is relevant for the destinations towards biodiversity and ecosystem services mainly contributing to access to a wider range of crops and breeds with a broadened genetic base is improved in line with global biodiversity commitments it also supports the practices in agriculture and forestry support biodiversity and the provision of other ecosystems services in addition belis will have a positive input on natural biodiversity reduction of air and water pollutions and farming system sustainability
chipscale visibleinfrared imaging sensor

according to the world health organisation road accidents are the eighthbiggest cause of death worldwide bad weather dangerous road conditions and distracted or fatigued driving account for nearly 70 of all accidents current driving monitoring systems dms and advanced driverassistance system adas underperform in harsh conditions do not guarantee high standards of security and simply do not provide the needed supportive information to drivers swir shortwave infrared is what is missing swir light thanks to its peculiar physical properties allows for better vision in critical visibility conditions such as fog night dusk and dawncheers chipscale visibleinfrared imaging sensor aims at developing a multispectral image sensor which thanks to a unique patented electronic structure is capable of selectively detecting the visiblenear infrared visnir and swir regions of the electromagnetic spectrum being based on si and ge photodiodes monolithically integrated in a single device eye4nir technology is fully compatible with mainstream foundry processes harnessing their scalability and costefficiency to its advantage as opposite tocurrent swir imaging technologiesthe robustness of our approach is proven by very promising results on labscale prototypeswithin cheers eye4nir a fabless image sensor supplier aims at manufacturing a first hd visswir chip ready for highvolume productions target market is automotive where the demand for dms and adas is growing also because of regulatory constraintsand where price makes the difference cheers is effective reliable and versatile being an enabling technology it can be implemented in other application domains such as industrial automation consumer electronics and noninvasive quality controlsemiconductors are key for europes competitive leadership in the era of the digital economy eye4nir aims to grow and become a key fabless player in the ecosystem
investigation of the ignition of a wallimpinging jet on a hot surface fuel jet and liquid gas jet

accidental ignition of liquid fuels is a critical safety and economic concern for the chemical aerospace automotive and petroleum industries a fundamental understanding of ignition processes is crucial to reduce accidents and exacerbated pollution emissions through safer and more optimized designs even though hot surface ignition is a wellrecognized hazard it is only superficially understood and safety guidelines tend to oversimplify the phenomenon hephaestus project is born from the will of two recognized research centers to merge their expertise to address this issue the von karman institute for fluid dynamics vki in belgium and the explosion dynamics laboratory edl of the california institute of technology caltech usahephaestus aims at improving the knowledge on the ignition processes of a jet impinging a hot surface a world unique experimental setup will be designed to provide an indepth optical investigation of the fuel jet ignition an experimental database will be generated analyzed and diffused into the scientific and safety community the data will be first used to test the existing numerical models it will be extensively analyzed to detail the different ignition mechanisms finally it will be applied to test engineering models and propose new safety guidelinesvki is developing a new laboratory on the use of flammable liquid gas for propulsion the knowledge acquired during the projects first stage about experimental analysis of ignition mechanisms will be used to support the development of this new leadingedge laboratory an existing vki setup will be adapted for ignition characterization by implementing the newly learned experimental technique and the experimental protocol will be optimizedhephaestus project will improve safety via an enhancement of the ignition processes understanding and the diffusion of a fundamental scientific database to be used for future research
designbased datadriven decisionsupport tools producing improved cancer outcomes through usercentred research

patients with cancer often have to make complex decisions about treatment with the options varying in risk profiles and effects on survival and quality of life datadriven decisionsupport tools dsts have the potential to empower patients support personalized care improve health outcomes and promote health equity optimal decisions also for underserved groups however dsts currently seldom consider quality of life or individual preferences and their use in clinical practice remains limitedto address these challenges the 4d picture consortium will further develop a promising methodology metromapping to redesign care paths that include novel dsts we will better predict treatment outcomes by developing innovative algorithms and incorporating patient experiences values and preferences using aibased models in cocreation with patients and other stakeholders we will develop datadriven dsts for patients with breast cancer prostate cancer and melanoma we will evaluate these dsts as part of metromapping as well as standalone to ensure their sustainability as well as addressing social and ethical issues we will explore the generalizability of metromapping and the dsts to other types of cancer and across other eu member statesimproved care paths integrating comprehensive dsts will empower patients their significant others and health care providers in decision making and strengthen care at the system level by improving resilience and efficiency whereas the 4d picture consortium includes leaders in modelling ai decision making citizen science service design ethics risk communication and policy making this project will impact clinical practice and science across europe and beyond