Dragon09/odtu_chatbot huggingface dataset:
shaping cortical computations via higherorder feedback

our ability to flexibly adapt to changing environments depends on how we perceive prioritize and act on stimuli this involves actively integrating our current sensory experiences with our prior knowledge of the world and the surrounding context stimulus perception is influenced by contextual topdown signals from areas higher up in the processing hierarchy that carry information about internal state attention and future actions to early processing stages where they are combined with bottomup inputs commonly referred to as feedback these topdown signals are multifaceted they come from diverse brain areas and are integrated at different loci in neural circuits what type of information they carry and where is still unclear despite their fundamental role in shaping even the most mundane tasksfeedbackcircuits will investigate the mechanistic circuit basis of feedbackdriven cortical computations including contextual modulation and the amplification of unexpected stimuli and will pinpoint the synaptic plasticity mechanisms governing the wiring logic of feedback projections constrained by experimental data from the mouse visual cortex i will build a multiscale theoretical framework that unifies diverse experimental findings and links cellular to circuitlevel processing our strategy leverages new datasets that encompass multiple modalities from neural responses in various brain regions to detailed synapticlevel wiring diagrams the proposed mechanistic models will enable the exploration of distinct feedback sources and sites of plasticity and together with the data define plausible parameter spaces underlying feedbackdriven computations in contrast to other efforts training hardtointerpret artificial neural networks our models promise to elucidate the mechanistic underpinnings of circuit structurefunction dynamics involving feedback to distinguish between competing mechanistic hypotheses and make numerous experimental predictions
a comprehensive trustworthy framework for connected machine learning and secure interconnected ai solutions

the contemporary ai landscape demands a holistic framework ensuring security across the supply chain and entire ai lifecycle despite existing adversarial attack techniques a comprehensive endtoend flow for identifying threats and vulnerabilities with associated risks is lacking the eu through initiatives like the ai act emphasizes safety and trustworthiness in ai applications but lacks a system managing weaknesses in a networked aisupply chain the coevolution project integrates its architecture components to create an endtoend security trust and robustness str assessment solution generating contextaware ai models characterized by their ai model bill of materials aimbom the goal is a universal hub providing a coherent str risk assessment and security assurance flow aligning with mldevops and eu ai regulatory frameworks the paradigm includes novel ai model descriptions aimbom management security monitoring and context awareness coevolution introduces a new str paradigm based on billsofmaterials offering a unified approach to describing ai models in supply chains ensuring str compliance with eu directives on trust fairness data governance and gdpr guidelines open source trusted datasets and coevolutiondeveloped ai models enhance the hubs capabilities aiming for a robust adaptable risk analysis and security assessment framework aligned with evolving ai cybersecurity threats
european pilot line for beyond 2nm leading edge systemonchip leadership

nanoic will provide europe with a beyond 2nm leadingedge soc pilot line for advanced logic memory and interconnect technologies to strengthen european leadership in advanced technologies development for markets like computing communication mobility energy and health the objective of nanoic is to deliver a 300mm pilot line to the entire semiconductor ecosystem to address the challenges defined in the cpl1 call of the european chips act technology development will go up to trl 36 for i logic nanosheet ns n2 a14 a10 and complementary fet cfet a7 and beyond device architectures and highna euv ii the advanced memory options spin orbit torque sotmram embedded dram and 3ddram iii advanced electrical and optical interconnects like dietowafer hybrid bonding finepitch redistribution layer technology chiplet enablement laser dietowafer integration on 300mm photonic interposerssustainability is a focus area aimed at energy efficiency reduction of greenhouse gas emission and water usage of the baseline flows supported by automated tool and process data acquisitionpdks on nanoic baselines for academia startups smes and industry will be supported by a design enablement facility and training these include design pathfinding pdks for prototyping and dtco at the device and circuit level and system exploration pdks for prototyping system functionality combining nanoic and foundry technologiesdissemination exploitation and communication actions will engage all stakeholders in paneuropean collaborations expanding the community of interest for these advanced technologies the nanoic pilot line will build on the collaboration of imec cealeti france fraunhofergesellschaft fhg germany vtt finland cssnt romania and tyndall institute ireland but will offer many opportunities for projects with the wider rd community
truly carbon neutral electricity enhanced synthesis of liquefied natural gas lng from biomass

carbonneutrallng targets the truly carbon neutral use of biogenic carbon to replace fossil fuels for the transportation sector with renewable electricity enhanced biolng nonelectric transport will depend on liquid and gaseous energy carriers like liquefied natural gas lng biolng is particularly advantageous as high density liquid fuel for the heavy duty truck and the marine transportation sector a proposed hybrid catalytic process combines chemical catalytic and biological methanation with electro methanogenesis in order to reduce process complexity and maximise carbon efficiency lowcost renewable electricity will be the main driver for reduced marginal costs for the biolngs production the experimental work addresses the hybrid catalytic process chains main units and focuses on the development and testing of a sorption enhanced egasifier wp1 and additively manufactured chemical catalytic raw methanation reactor wp2 and the biological methane conditioning wp3 by means of biological methanation and electromethanogensis work packages 4 and 5 will include an impact assessment at environmental and socioeconomic level wp4 and a roadmap to replication market and policy assessment wp5 they will mainly address monitoring and avoidance of fugitive methane emissions facing the upcoming regulation eu on methane emissions reduction in the energy sector and will in particular prepare technical and legal recommendations to avoid methane emissions in lng infrastructures artificial intelligence ai based advanced process control and scaleup considerations wp6 and the operation of the complete process chain will finally provide a proofofconcept for the proposed process at trl 34the work package coordination and dissemination wp7 establishes a technology transfer and dissemination multiplier board with stakeholders and policy makers and will include several workshops conferences and social media communication
a unique fermentation platform for the production of a local circular and sustainable alternative to palm oil from biowaste streams

at nopalm ingredients we aim to produce the firstever sustainable circular costcompetitive and locallyproduced alternative to palm oil and other vegetable oils our unique fermentationbased bioprocessing technology platform that can turn agrifood waste streams into fermented oils fats is instrumental to this effortpalm oil is found in 50 of all supermarket goods and 70 of all personal care products with the increasing global population the global palm oil demand is expected to triple to 240 mt by 2050 however palm oil production is responsible for 15 of global ghg emissions and 23 of global deforestation due to this the european deforestationfree regulation now obliges fmcg companies to use sustainably produced rspocertified palm oil yet only 17 of palm oil produced today is rspocertified this percentage will decrease further by 1040 due to climate changeinduced oil palm plantation yield lossesour fermentationbased technology enables us to produce tailormade oilsfats that can directly replace palm oil in food personal care cleaning and cosmetics products uniquely we use agrifood waste streams in our process as feedstock and we have 23x higher overall process efficiency compared to the stateoftheart compared to palm oil production our technology has 935 less co2 footprint and reduces land use by 999over the last decade imported palm oil use constituted 30 of all vegetable oil consumption in the eu our technology will provide the capacity to locally produce fermented oils that can directly replace palm oil imports and become a critical tool for ensuring food sovereignty for europeour team of 18 is led by lars langhout ceo with 12 years of experience in strategy consulting and innovation management and prof jeroen hugenholtz cto a renowned microbiologist and fermentation expert with 40 years of fermentation experience
circular initiative for recycling and waste conversion into lactate extracts

circle aims at demonstrating at industrial scale a firstofitskind retrofitted biorefinery for the valorisation of food waste streams and additional biomasses into highvalue biobased chemicals and intermediates lactic acid la as well as derived products including polylactic acid pla upgrading and expanding the production capacity of an existing biogas plant the upgrade proposed will valorise the food waste streams currently processed for biogas production to produce la ready for downstream highvalue applications including the production of pla and derived new and highervalue products the process will take advantage of the existing facility and of the renewable energy biogas and heat directly produced thus making the production highly energy efficient the proposed technology is highly scalable and replicable as it is designed to be deployed as an addon to existing food waste processing infrastructures circle will reach the trl8 by the end of the project by demonstrating the production of raw la which will be then converted into clean lactate salt cls and into industrial and polymergrade la 9599 the polymergrade la will be in turn polymerized into a recyclable pla which can replace fossilbased polypropylene pp in a wide range of applications with a significant impact on ghg emissions and environmental pollution avoidancethe application of biobased chemicals and intermediates will be demonstrated through the production of a wide portfolio of biobased products fully compliant with market requirements such as cover cosmetics products for cls and la cleaning products for la as well as the automotive cosmetics and food packaging sectors for plathe new circular value chain is expected to generate 20m of turnover and ca 50 jobs retrofitting the existing biorefinery will allow saving at least 10 of the capex
a lightefficient microscope for fast volumetric imaging of photon starved samples

bioluminescence microscopy offers a powerful tool for background free imaging of biological samples without an excitation laser this enabling technology would afford a wide range of applications in the life sciences where fluorescence microscopy is prohibitivecurrently commercial solutions for bioluminescence imaging suffer from low spatiotemporal resolution due to photonstarved samples lowlitescope aims to overcome these limitations by radically redesigning the optical path data acquisition and post processing based on artificial intelligencelowlitescope leverages a new light field approach to capture the spatial and angular information of light rays that pass through the sample in contrast to conventional light field microscope this technique records threedimensional images with high spatial resolution and a large depth of field to econstruct the 3d volume from single exposure light field images we will use new deep learning models based on artificial intelligence wp1 the use of generalized and opticsinformed deep learning techniques will also increase the spatial resolution beyond conventional light field microscopes we will test the performance of the lowlitescope prototype using photosensitive samples and samples with high intrinsic autofluorescence wp2 two properties that often render longterm highresolution imaging via fluorescence microscopy difficult ultimately success is measured by the ease to adopt our technology to facilitate the adoption of lowlitescope by the enduser we propose a new lens design which can be used as a modular addon to any conventional fluorescence microscopes wp3in summary lowlitescope marks a significant breakthrough in bioluminescence microscopy its ability to noninvasively capture 3d images of live cells and tissues with high precision will be an invaluable asset for the advancement of biomedical research
female fundraising leadership in advanced technologies for brain disorders

the goal of this project is to run a fundraising campaign taking into account the very impactful core of our business at alpha brain technologies as the business lead and ceo i am responsible for every financial and investment related aspect of the company in the past two years we have achieved a tremendous amount of technical advancement for epilepsy while not disconnecting from the patients and caregivers community in this project i am aiming at taking this stakeholders involvement in further pursuing their active participation in our fundraising campaign to run clinical trials and commercialise our developed solution a solution that has no other goal but solving some of the stakeholders most devastating problems
decoding the molecular logic of gpcr signaling

g proteincoupled receptors gpcrs are key to human physiology and disease yet their signaling remains enigmatic what we do know is that gpcrs signal by means of allosteric communication across the cell membrane acting as logic gates that relay signals from extracellular ligands to various intracellular transducers nonetheless the logic underlying gpcr signaling at the molecular level is not yet understood this is particularly true of three key signaling phenomena ligand efficacy biased signaling and allosteric modulation in signallomod we will address this challenge and investigate the logic of transmembrane signaling through gpcrs at the singlemolecule level we will develop smmdsfret a groundbreaking method that integrates singlemolecule microfluidic diffusional sizing smmds with singlemolecule förster resonance energy transfer smfret by simultaneously measuring binding smmds and conformations smfret this method will make rigorous quantitative models of gpcr allostery experimentally accessible this will allow us to separate for the first time ligandspecific from transducerspecific effects in gpcr signaling thereby decoding the molecular logic of gpcr signaling we will use the adenosine a2a receptor as a wellstudied model gpcr to establish our approach we will then study ligand efficacy through the 2 adrenergic receptor explore biased signaling through the angiotensin ii type 1 receptor and examine allosteric modulation of all three receptors by ions small molecules and lipids the quantitative insights into ligandspecific and transducerspecific effects afforded by signallomod will redefine our understanding of gpcr signaling signallomod will provide pharmacological ligand profiles with unprecedented detail opening new horizons for drug discovery and pharmacological intervention guided by physical principles
advanced multidisciplinary research for antimicrobial resistance

we are proposing a 4year program of knowledge transfer and networking between academic institutions university of leicester uk university of valencia spain international iberian nanotechnology lab portugal university of bologna italy university of aveiro portugal fudan university china and alfred university usa and industrial partners teer coatings ltd uk the objective of the proposed joint exchange programme is to establish longterm stable research cooperation between the partners with interdisciplinary expertise and knowledge to develop advanced multidisciplinary research for antimicrobial resistance amramr including the development of novel antibacterial nanomaterials and nanostructures novel antibacterial thin films coatings upconversion technology for amr applications photonics technology for amr application and evaluation of the antibacterial performance and antimicrobial resistance the synergetic effect for the above approaches to understanding antimicrobial resistance antimicrobial resistance amr refers to the ability of microorganisms such as bacteria viruses fungi and parasites to resist the effects of antimicrobial drugs such as antibiotics antivirals antifungals and antiparasitics amr is a serious global public health threat that could lead to increased morbidity mortality and healthcare costsworld health organisation who has declared that amr is one of the top 10 global public health threats facing humanity the covid19 pandemic has highlighted the importance of amr as it has led to increased use of antimicrobial drugs particularly antibiotics which can contribute to the development of amr people with covid19 may develop secondary bacterial infections such as pneumonia and may be prescribed antibiotics to treat these infections however unnecessary use of antibiotics can lead to the emergence and spread of resistant bacteria making it more difficult to treat infections in the future
demonstration of longendurance intelligent multipurpose autonomous vehicles for marine applications

the importance of our seas and oceans to the economy and societal wellbeing is broadly acknowledged in addition offshore infrastructure in the form of ports wind farms aquaculture facilities natural gas pipes etc has continuously expanded and has become more commonplace in recent years activities associated with seabed mapping monitoring of the health and status of marine habitats offshore infrastructure inspection seabed mining and underwater sensing have traditionally been based on the use of crewed support vessels which are expensive to run and have limited endurance the merlin project seeks to exploit longendurance operational capabilities offered through the use of hydrogen fuel cells and renewable energy installed onboard unmanned surface vessels usv and autonomous underwater vessels auvs which are capable of navigating and operating autonomously based on ai algorithms without the need for human intervention a mission remote control centre mrcc will permit data from the autonomous vessels to be transmitted to base conversely the mrcc will allow the transmission of commands from the supervisor to the robotic vehicles the vehicles will incorporate advanced surface and underwater grasping capability for the collection of samples handling installation and recovery of sensors using custombuilt robotic arms the usv will provide geotagging reference data to the auvs when they operate underwater and be able to track them during the mission the usv will be able to navigate from its base to the location of the mission where the auvs will be released at the end of the mission the auvs will dock again with the usv so they can be safely returned to base the vehicles will be capable of operating independently as well as in combination with support vessels the demonstration activities include three different high value use cases including marine habitat monitoring underwater volcano seabed mapping and port infrastructure inspection
flawless and sustainable production of composite parts through a human centred digital approach

the reduction of manufacturing waste is a key challenge to achieve a europthe reduction of manufacturing waste is a key challenge to achieve a european transition towards climate neutrality and the goals of the green deal in this context to achieve the zerodefect manufacturing paradigm has becomes a must for those european productive companies that wants to take the step towards sustainable productioncomposites play an important role in strategic european manufacturing sectors like energy aerospace naval or automotive with a growing forecast so flashcomp project will develop a humanoriented solution capable of identifying in an earlymanner feasible defectiveness in composite parts manufacturing and to determine if corrective actions should be adopted all with the ultimate goal of optimizing the composite manufacturing process reaching zerodefects and consequently reducing the generation of waste process and product associatedflashcomp will develop nondestructive inspection and monitoring instruments to retrieve key process parameters will develop an online defect severity estimation tool that will predict the appearance of defects and will estimate their severity to suggest the optimum feedback and feedforward control strategies and will develop a decision support system in addition an interoperable software platform for datasharing will be createdthe full flashcomp solution will be demonstrated in a test bed enabling the experimental validation of the flashcomp concept and 2 industrial use cases assuring its future replicability and paving the way for a future exploitation of resultsflashcomp will include a complete skills development training program since the flashcomp solution has been conceived to assist the operator in controlling and making decisions about the manufacturing process finally the project will deal with the development of a standardization roadmap to ensure the widest possible impact of project results
eulac for energy transition research infrastructures cooperation for energy transition between europe and latinamerican and the caribbean countries

eulac energytran intends to strengthen the cooperation between the european union and latin american and the caribbean research infrastructures to tackle a common challenge how to get a clean sustainable and just energy transition this project pursues its goal through the exchange generation and transfer of knowledge among entities from a multidisciplinary approach technological environmental social and through the support to the development of public policies and regulatory frameworks towards climate neutrality this general goal will be achieved by four specific goals that respond the multidisciplinary approach in tune with the complexity of the energy transition therefore the project supports technological ri to overcome the existing limitations of renewable energies but acknowledging these developments may have an environmental and social impact which must be addressed this proposal wants to come up with ideas about how to achieve an energy transition compatible with environment protection and social justice energy transition is at the top of the political agendas of both regions eu and lac so this project may contribute to consolidating it as a priority area of interregional scientific cooperation this project will be carried out by a heterogenous and interdisciplinary consortium composed of eleven partners with wide presence in the eu and lac they include erics and an international organization among other entities from different areas of knowledge this way the complexity of the energy transition is better tackled under this scheme eulac energytran will create a network of an interconnected and sustainable eu and lac research infrastructures that contributes to energy transition by technological social and sustainably strengthening the performance of entities through shared knowledge and close interactions among researchers this common effort will mean a step forward in both regions to reach a society that needs to be resilient