Dragon09/odtu_chatbot huggingface dataset:
conserved developmental trajectories channelling lateral root primordium morphogenesis

the root system anchors the plant to the ground and absorbs water and nutrients to sustain plant development understanding root development and its adaptative behaviours to changing environments is a major goal of the 21st century this interdisciplinary project aims to identify a conserved developmental program between a nondomesticated model plant brachypodium and a cultivated legume crop lupin secondary root formations such as lateral root lr and cluster root cr are significant contributors to the adaptative nature of the root systems architecture this work will initiate five new collaborations and reciprocal expertise transfers that will benefit both the host labs and the researcher preliminary results from the hosting labs showed that brachypodium lr and lupin cr organogenesis share common developmental stages the objectives of plantid are i investigating the developmental trajectories of lr cells in brachypodium and ii identifying key cell wall cw regulators required for lrcr development in brachypodium and lupin the first phase of plantid will be conducted in the laboratory of cell and molecular biology at the university of neuchtel ch and the second phase at the ipsim institut for plant sciences of montpellier montpellier fr the two research labs have complementary experiences in the root development of those organisms secondment at mpimp laboratory in potsdam will generate the first cw atlas in lr morphogenesis for the two species i will lead this fellowship with my strong expertise in cw biology and lr development i will identify genetic regulators that impact nutrients and water uptake with a high potential for agricultural applications in cereal species eg biofuel and crop productivity the project objectives support the strategic plan for research and innovation in the horizon eu 202124 and the eu green deal restoring eus ecosystems and biodiversity to manage sustainable agriculture cluster 6
closing the european gap towards a large scale ex vivo platelet production built upon a silkbased scaffold bioreactor

the generation of ex vivo functional megakaryocytes mk and platelets is questioning current transfusion medicine exclusive reliance on blood donors to produce platelets the demand for platelets is in fact in continuous rise driven by an aging population advances in medical procedures and even more aggressive cancer therapies although the supply of blood donors continues to remain stagnant ex vivo platelet production systems have then emerged as a feasible supply that can moreover secure universal compatibility to avoid platelet refractoriness if during the fet open application we have proved that the platelet production ex vivo can be precisiontailored with the correct physical and biochemical environment now with silkplatelet our consortium is looking forward to demonstrating the feasibility of an upscaled ex vivo production system to bring then our technology from trl4 to trl6 we will increase the ex vivo platelet production capacity with media and stem cells aligned to gmp requirements for largescale clinical transfusion our goal is to produce universal platelets particularly for patients with immune reaction to previous transfusions with hla null platelets and patients with acute hemorrhage at the core of our from labtopatients roadmap we will find both unicam proprietary technology to differentiate stem cells into mk precursors natural source of platelets and unipv disruptive bioreactor made of a silkscaffold to mimic the bone marrow conditions these will be then complemented by igr longterm experience in ipsc and mk biology and isenet cell quality control contribute to the standardization of the platelet production pipeline and its validation and verification under the guidance of our experienced tech transfer officers by the end of the project we expect to complete the transition into a commercial innovation exploited by a next university spinout
graphite resilience for lithiumion battery anodes through a sustainable european endtoend supply chain

the project gr4fite3 aims to reach graphite resilience for lithiumion battery anodes through a sustainable european endtoend supply chain this supply chain includes environmentally responsible european mining of natural crystalline flake graphite from europes largest natural graphite resource highly innovative continuous and low energy input upgrading of the mined ore adding recycled and fully repaired for reuse synthetic graphite and optionally silicon nanoparticles to compose a unique anode active materials particle architecture making the high density anodes creating the cells developing battery modules certifying the lithiumion batteries for safety and viability and ultimately using these products by the oems including an established european electric bus manufacturer and a utility grid developer among others the purpose of gr4fite3 project is to demonstrate the creation of a sustainable supply chain for the european industrial graphite and carbon products for specific use as anode active materials in lithiumion batteries designed for applications in electric vehicles and power sources for utilities such as solar and wind farms this project is going to combine the efforts of 10 partner organizations from six european nations employing both industry and academia there are also four oems and five supporting organizations who have expressed their interest in tracking projects progress and parttaking in a tangible manner in commercialization efforts associated with gr4fite3 projects outcomes with this larger group of stakeholders the project spreads its reach to as many as ten countries and three continents ensuring its global outreach from the very start
tackling the peak assignment problem in xray photoelectron spectroscopy with first principles calculations

xray photoelectron spectroscopy xps is one of the most widely used methods of characterization in applied surface science it is applied in studies of heterogeneous catalysis environmental degradation corrosion the manufacture of surface coatings and various other processes however the practical value of xps measurements is currently negatively affected by widespread problems in the analysis of recorded spectra these have been extensively discussed in recent scientific literature and problems with peak fitting and peak assignment in core level xps have been identified as a source of significant errors in the analysis of xps spectra these problems can limit the amount of useful chemical insights that xps is able to provide and moreover incorrect peak assignments can lead to the wrong conclusions being drawn about the underlying chemistrythe aim of this research project is to tackle these problems by enabling and encouraging the more widespread use of computational methods in the interpretation of experimental xps spectra and to thereby make xps a more reliable and more useful method of characterization specifically we want to make existing computational methods for calculating core electron binding energies and simulating core level spectra accessible to a wider community of researchers and to improve these methods such that they would better meet the needs of xps users we will develop new computationally efficient and userfriendly implementations of the scf method and the gwcumulant approach carry out casestudies that are designed to test the limits of current theories in guiding the analysis of real world spectra and organize workshops and write tutorials to increase the user base of the computational techniquesthe planned work will be carried out by an international interdisciplinary and intersectoral team of experts in theoretical spectroscopy developers of electronic structure codes xps users and instrument manufacturers
breaking frontiers in sustainable and circular biocomposites with high performance for multisector applications

biontier offers innovative solutions to environmental challenges and establishes a holistic integrated and industrialdriven platform for the design development and scalable fabrication of the next generation of costeffective sustainable lightweight recyclable biobased composites bioc with enhanced properties eg thermal mechanical chemical functionalities eg corrosion chemical and fire resistance hardness and impact resistance high temperature resistance structural health monitoring biontier will also advance manufacturing processes enhancing synthesis and stability and reducing environmental impact such bioc and manufacturing capabilities will allow robust connections with endusers and thus develop and qualify the commercial propositions to high trls biontier will develop demonstrate and validate the efficacy of biocenabled products 6 use cases which will underlie future technologies for different sectors eg automotive aerospace energy hydrogen economy and water treatment biontier also supports the innovation output and industrialization efforts of the eu initiatives and strategies for circular bioeconomy building a credible pathway for the newly accumulated knowledge to impact eu industry and society biontier will support a strong eu value chain in translating technology advances from trl45 into concrete innovation opportunities and production capabilities trl67 with firstmover market advantages of scale in the defined industrial sectors the consortium consists of 25 partners from 12 countries representing the full value chain with leading oems large industries worldclass research and education organisations and innovative smes biontier is designed to ensure maximum impact for the defined industries and society as a whole significantly contributing to the evolving field of bioc
optimizing stratification for trial design in alzheimers disease

alzheimers disease ad heterogeneity is associated with distinct risk factors clinical manifestations rates of cognitive decline and comorbidities however this population variance is not properly incorporated in clinical trial design directly hampering successful development of treatments as the field is shifting towards early secondary or event primary intervention the overall objective of the current project is to optimize clinical trial design of an early ad population by providing datadriven guidelines for sample stratification and outcome measures to this end i will assess neurobiological heterogeneity in 2000 cognitively unimpaired cu and 900 mildly impaired mci subjects enrolled in the biofinder study from lund university host institution using their unique dataset i aim to identify subtypes of amyloid avascular interplay the two most common cooccurring and interacting pathologies in the aging brain next the role of neuronal function microglial activation and novel targets through proteomics analyses based on csfplasma biomarkers on disease progression within these subgroups will be determined finally resulting taupet accumulation patterns and cognitive decline across domains across will be assessed a main innovative aspect and strength of this project is the utilization of regional information available from the imaging modalities an aspect of analyses which i have specialized in in turn the expertise of the host institution regarding fluid biomarkers and taupet imaging is paramount to support this multimodal project finally our respective experience with longitudinal study design will support a critical aspect of the project which is lacking even in the most comprehensive studies to date unravelling heterogeneity in disease trajectories is paramount to optimize trial population selection and stratification directly increasing the changes of positive trial outcomes
cryogenic storage and refuelling in space

to move away from the dependence on hydrazine for space propulsion greener alternatives must be sought cryogenic propellant combinations such as oxygen methane offer higher specific impulses than storable combinations but their low saturation temperatures raise additional challenges with respect to preventing their evaporation during longterm storage while the ability to refuel craft with cryogenic propellants would allow for longerterm manned missions to mars and the moon as well as aid in the improvement of inspace sustainability preventing the evaporation of the propellants during the transfer process also poses challenges as of today neither longterm storage nor refuelling with cryogenic propellants has been demonstrated inorbit crysalis will develop and mature the technologies needed for the management of cryogenic propellant for future space transportation and inorbit servicing activities this maturation will include performing a smallscale inorbit demonstration to mature those whose performance can only be characterised in a microgravity environment this will be a closedsystem demonstrator flown onboard the nyx capsule which will aim to not only demonstrate the feasibility of such processes but will aim to improve the understanding of the behaviour of such propellants under microgravity allowing for development of future systems these technologies will aid in ensuring the independent access of the eu to space in particular to manned and heavy missions beyond geo and leo by supporting the development of a logistical network of craft depots and hubs required for cislunar and future martian missions
manuscript culture in the age of print

the prima project will redefine our understanding of how culture was produced and disseminated in early modern europe 15751800 prima will uncover the importance and the scale of manuscript production and publication for literature science music and other areas for a period when print is believed to be the dominant if not the only technology for publication by investigating the indissoluble connection between text and carrier prima will explore how manuscripts have shaped society for much longer than believed the prima project will unveil the rich manuscript culture that hides in the plain sight of scholars and answer why so many manuscripts were produced by whom for whom and how we will assess the existence of modern scriptoria uncover monastic writing practices in the modern period and focus on manuscript production within universities and academies for literature particularly satyric and lyric poetry and theatre it is our argument that manuscript dissemination is the norm and that print is exceptional we will focus particularly on italy while allowing for significant openings towards other cultures italian manuscript production and consumption are both exceptionally rich and understudied adopting qualitative and quantitative methods and innovative computational approaches for data mining production and retrieval will ensure the projects feasibility the investigation of postprint manuscripts will uncover unknown works which will help redefine our understanding of literary production for the 17th through the 18th centuries by fighting teleological prejudices about the inferiority of manuscripts with respect to print from the 16th century onwards finally prima will also investigate cases of printmanuscript hybridisation where manuscripts imitate print or include printed sections the projects main outcomes are the creation of a new discipline and a centre for modern manuscript studies a book collection and an oa
replicable and efficient solutions for optimal management of crosssector energy

the resonance project develops an innovative software framework that provides means for rapid development and plugandplay deployment of standardcompliant customer energy manager cem resource manager rm and their aggregation solutions the cem specified in the en 5049112 standard family is the nextgeneration demandside flexibility management dsfm solution in europe cem is a software agent that automates dsfm by interacting with smart appliances represented by rms aggregators and the markets to maximize customer benefits according to the new en 50491122 standard cems are envisioned to 1 provide a more deterministic demand response and 2 be able to optimize consumer benefits with respect to multiple incentives and optimization targets to achieve this there is a need for accurate models of flexible assets smart appliances and model predictive control techniques to automate the decisionmaking within the customer premises the resonance framework will facilitate the adoption of cems as the next generation dsfm system by significantly reducing the development efforts and costs this is achieved with 1 a standardcompliant and modular system architecture and 2 an innovative modeling pipeline that combines automated machine learning automl with physicsbased modeling to provide accurate and robust models of flexible assets with minimum effort the project brings together 19 partners including a cluster with 40 organizations with interdisciplinary expertise and forms a basis for a crosssector energy ecosystem that significantly contributes to the mobilization of dsfm at a large scale large scale piloting in six member states with a variety of consumer sectors flexible assets eg electric vehicles hvac systems and white goods stakeholders and market settings including sector integration with district heating is utilized for demonstrating and validating the scalability and replication potential of the solutions
digitalised value management for unlocking the potential of the circular manufacturing systems with integrated digital solutions

the aim of the current project is to bring about the development of the full demonstrator of dicim a set of integrated digital solutions that makes use of internet of things iot machine learning ml based artificial intelligence ai big data image processing and augmented reality ar to support different actors of the industrial value chain such as managers engineers and operators in their decision making and to carry out value recovery activities for circular economy the integrated digital solutions include an open access digital platform for lifecycle information management and support solutions for value recovery activitiesdicim project revolves around the value use and value recovery phases of the circular value model cvm with the specific data technology and the management needed to support its implementation in particular it focuses on integrated digital solutions to enabling condition monitoring during the use phase optimizing the reverse logistics and achieving efficiency and responsiveness in the value recovery activities ie collection inspection sorting disassembly testing and repairingrefurbishingremanufacturingrecycling to enable reuse of products parts and materialsdicim project will demonstrate integrated digital solutions in four use cases in three industrial sectors that represent over two thirds of the european economy they include whitegoods ie refrigerators washing machines electronics ie printers and automotive with important gains such as increase in spare part recovery efficiency by 90 which means 126 000 labour hours are saved for refrigerator demonstrator and increase in spare part recovery rate by 20 about 2920 tons net material saving for washing machines and 6000 tons for automotivedicim digital solutions will boost new circular economy business models based on value recovery activities to sustain and encourage remanufacturing throughout europe
solutions to prevent and mitigate the impacts of habs in aquaculture and fisheries in the context of global warming

harmful algal blooms habs are considered a threat to the environment and to human health major concerns are addressed to the increasing occurrence of these natural events in certain regions of the world driven by global warming and anthropogenic pressure human illnesses related to the intake of contaminated seafood have been attributed to these events furthermore habs have a significant impact in economic activities such as aquaculture and fisheries the occurrence of habs in natural areas utilized for aquaculture or harvestingfishing can affect species growth and nutritional parameters or even cause mass mortalities causing huge losses in the industry the regulation of toxin levels in seafood and other measures eg forced closures to seafood harvest during the occurrence of habs have been contributing to protecting humans from serious intoxications on the other hand the impacts on the industry lack mitigation measuresthis project aims to contribute to the development of solutions for the aquaculture and fisheries sector through the development of efficient methods for the detection of habs early warning and the development of farming and depuration systems for shellfish to reduce the toxin load the project also aims to advance in the understanding of regulated and emerging toxins chemical and toxicological evaluation and their global expansion and toxin incidence and persistence in seafood traditional and nontraditional vectors species not yet investigatedfor the implementation of the project an interdisciplinary consortium was built which brings together specialists from different areas of knowledge and who will develop joint research and innovation activities which collectively will contribute to the technological innovation of the aquaculture and fisheries and sustainable growth of this sector and to environmental monitoring
green horizon on organic semiconductor technologies

the green deal has made it necessary to develop low power electronics using sustainable materials and green processing the successful implementation of amoled active matrix organic light emitting diodes displays in mobile phones organicbased electronics illustrates that the green deal is possible however current organic electronics technologies have yet to be efficiency and not all are produced via low embedded energy processing methods by using bio inspired organic materials deposited by green process technologies achieving these goals could be realised during project ghost we will focus on inter molecular interactions to help address these issues irrespective of application amoled organic photovoltaics opv organic fieldeffect transistors ofet or organic thermoelectric generators otg the active materials are used in a solid matrix that stabilises them but also changes their properties relative to those in solution there are many examples where guesthost interactions eg donoracceptor materials in opv devices completely change the properties of the system using lightemitting guests blended in a host or donoracceptor exciplex systems leads to increasing oled emission efficiency but how to control these interactions is not well understood and is still largely emipirical interactions can change both the molecule conformation and electrooptic properties of the materials but theoretical approaches to understanding these mechanisms are still in their infancy moreover the varried effects of such intermolecular interactions in working devices is very poorly understood currently our limited understanding of these phenomena limit our ability to develop bio inspired materials and active components all life on earth is organic and can perform complex of functions taking inspiration from living organisims we aim to develop a new low energy organic electronics technologies