Dragon09/odtu_chatbot huggingface dataset:
application of novel costeffective imaging tools for the monitoring of benthic ecosystems in the offshore marine area of cap de creus

the offshore marine area of cap de creus nw mediterranean characterised by its complex geological setting and rich epibenthic ecosystem was declared a site of community importance sci of the natura 2000 network in 2014 although environmental factors play a fundamental role in the distribution of benthic fauna commercial fishing was found to exert a significant effect on the diversity and structure of benthic communities especially on the softbottom areas of the shelf the marine strategy framework directive msfd determines that thematic strategies should be implemented to preserve its marine resources following an ecosystembased approach setting environmental targets and implementing a monitoring program to evaluate if conservation objectives are met there is currently an array of imaging technologies at our disposal that could be used to monitor the benthic ecosystems of this sci but most would require highly elevated budgets to be operated on a regular basis in this scenario the project monica aims to explore the potential of recently developed lowcost imaging technologies ie the azor driftcam to explore and monitor the shelf and slope habitats of cap de creus to provide a costeffective response to the demands of the msfd with this technology monica will identify changes in the composition and structure of benthic communities since the creation of the sci and generate a new baseline for the implementation of a correct monitoring program furthermore it will employ lowcost baited remote underwater videos bruvs to characterise the demersal fish assemblages and determine the functional role of benthic communities if successful these technologies could open the doors to generate essential data at a significantly lower cost in other areas of the mediterranean to assist in decisionmaking processes and policy development for the conservation and restoration of marine biodiversity in times of rapid changes
lectibodies to eliminate tumours

antibodymediated delivery of therapeutic compounds to tumor cells for the treatment of cancer is a rapidly growing multibillioneuro market one class of tumor markers the glycosphingolipids gsls are only rarely addressed in this context due to the difficulty of obtaining antibodies against them in this proofofconcept program we will develop a novel class of products lectibodies for the delivery of therapeutic compounds to tumorspecific gsls our lectibodies are based on a naturally occurring gslbinding protein with intrinsic tumor targeting capacity we will rely on a proprietary phage library technology to isolate lectibodies against gsls or cocktails thereof in this poc program we will optimize and apply our technology to specifically target oacetyl gd2 a gsl highly expressed in neuroblastoma tissues this will enable us to generate lectibodybased therapeutics against neuroblastoma in children a devastating disease for which the drug market is predicted to reach 118 million in 2022 we will explore two options for further business development a building off of our current partnership with ogd2 pharma a biotech based n nantes france and bcreation of a spinoff company which will license deals to several pharmaceutical partners based on pathology we will capitalize on the expertise in launching startups of our principle investigator and on close links with clinicians and industry partners our technology has truly groundbreaking potential as in principle chimeric lectibodies can be developed against virtually any tumorspecific cocktail of gsls thus opening the door for the development of novel therapies for several cancers thus following the development of neuroblastomaspecific lectibodies we foresee a wider range of future applications for our technology
a european wide network of livestock advisors well embedded in their akis ecosystems and exchanging practical knowledge in the longterm for sustainable livestock production

the eu farm to fork strategy which is at the heart of the european green deal aims to make food systems fair healthy and environmentally friendly sustainable livestock production must play a substantial role to engage the eu in green transition while ensuring farmers incomes and quality of life the main objective of livenet is to establish and build capacity of a network of advisory services across the eu increasing the knowledge sharing between advisors and among the whole akis and the adoption of innovative solutions for sustainable livestock production by farmers the project will achieve this through 1 the establishment and development of an eu network of livestock advisors based on existing networks and national akis covering the 27 eu members states the uk and switzerland to cover all mss the project will adopt a twinning approach 101 national networks will be created by the project partners and will engage with 18 associated networks through a twining program the network will cover all european pedoclimatic areas integrating 10 eu regional clusters the major livestock sectors and the main thematic challenges faced by breeders 2 the collection selection evaluation adaptation and validation of contextbased innovative advisory practices iaps which are technically economically socially and environmentally viable and will be replicated across the eu 3 the wide scaling of solutions through trainings demoevents and other activities towards advisors students and value chain actors to promote the adoption of the iaps 4 the connection with other regional national and eu projects initiatives and policy makers for better integration of livestock advisory organisations in the akiss the project embrace a multiactor approach gathering 20 organisations with a vast experience in advisory and sustainable livestock production representing a diversity of akis stakeholders farmers advisors researchers value chain actors
moving emotions towards confidence in the transformative appropriation for a meaningful understanding of cultural heritage a neuroscientific approach to european museums

metamuseum aims to create empathic encounters where citizens can understand the ch transformative nature through active participation emotional involvement and cocreation to develop the transformeans theory and related new professional skills based on neuroscience evidence to provide cultural professionals with principles and tools for designing cultural experiences and to monitoring the effectiveness of communicativenarrative solutions to reach different segments of citizens included disaffected public and nonpublic to foster empathy confidence and resilience toward contemporary changes to validate an appropriate measurement of empathic responses confidence and resilience in ch users via neurosciences methodmetamuseum adopts a transdisciplinary approach and a strict interrelation between theoretical and experimental work the first one will explore and develop indepth the transformeans theory principles develop stimuli to make people understand the ch transformative nature and encourage cocreation and personal interpretation the experimental work will measure the audiences cognitive psycho and neurophysiological responses to stimuli and interpret indicators related to confidence and resilience intended as a capacity to positively react to changesthe transformeans theory principles will be tested in 3 different settings pilots 1 traditional cultural setting museums 2 noncultural setting hospitals without focusing on therapy results but only on the ch power on people particularly lacking in confidence and positive thinking 3 hybrid setting physical and virtual in urban contexts and via social mediathe metamuseum objectives mobilise multidisciplinary expertise provide evidencebased principles and guidelines promote better and more democratic access to ch improve personal participation and ch understanding enhance confidence and address the sdg4 sdg10 and sdg11
a novel toolkit for the early diagnosis of hearing impairment edhi

approximately 4060 of the european population is at risk of developing hearing loss due to exposure to unsafe noise levels the edhi fellowship will develop a novel toolkit sensitive to the first signs of hearing loss appropriate for use as an early diagnostic this objective will be achieved by 1 ideating innovative behavioural and neurophysiological tests that will provide novel biomarkers of hearing performance and 2 developing an automatic classifier that estimates the degree of hearing damage based on these biomarkers the encouraging pilot data obtained to date along with the background experience of the applicant and supervisor in developing advanced signalprocessing methods and conducting hearing research situate them in an optimal position to conduct the planned research this fellowship has the potential to transform current clinical practice by providing clinicians with the necessary tools to diagnose hearing disorders that are currently undetected in approximately 1 out of 10 patients the early diagnosis of hearing difficulties will enable the provision of individualised recommendations to ameliorate a persons hearing difficulties and prevent any further deterioration thus reducing the risk of social isolation anxiety depression and dementia further a hearingpathology demonstrator will be developed for use in outreach activities to increase awareness amongst the general population of the adverse impacts of hearing loss and to assist policy makers in the design of effective prevention strategies in addition this fellowship lays the groundwork for a substantial bidirectional transfer of knowledge with the host institution and provides the opportunity to engage with top hearingrelated industry partners who have an interest in the commercial exploitation of this technology
reconstructing 200 years of genetic history in european wolves

wolves are an important apex predator species and their conservation in europe has been a key concern since their population collapse at the beginning of the 20th century increases of wolf population numbers in recent decades provides a positive sign for the viability of this species moving forward but has also led to the reemergence of wolfhuman conflicts thus maintaining the genetic health and biodiversity of this important natural predator species whilst minimizing such conflicts remains critical across europe in this project i will investigate the population dynamics and changing genetic makeup of european wolves over the past 200 years by utilizing a comprehensive nextgenerationsequence database of modern n927 and historical n586 genomes i aim to implement complex stateoftheart analyses to model the finescale demographic history genetic health and dog introgression of european wolves in recent times by working at the cross section of population genomics ancient dna and conservation this project will provide critical insights into the effects of recent population history events on the genetic makeup of this important predator species broad dissemination of the findings of this project to the scientific community conservation groups and the general public will directly assist in designing targeted management strategies to preserve the biodiversity of european wolves moving into the future by utilizing one of the largest genomic datasets for a wild animal species to date the novel methodologies applied in this project will provide a blueprint for future conservation genetics studies in other species
identifying the building blocks of memory for events

a fundamental property of episodic memory memory for our personal experiences is that it is composed of distinct events got dressed had breakfast cycled to work but what are these events how are they formed encoded and represented in memory classic theories of episodic memory focus on the representation of static events viewed as sets of associations between elements eg johncoffeekitchen yet there is no comprehensive theory that accounts for encoding and representation of dynamic events john entered the kitchen poured water over freshlyground coffee and waited for it to brew the meme project puts forward a new framework that builds on these classic models but introduces the dimension of time proposing an account of how dynamic events are segmented encoded and represented three work packages are designed to test predictions made by each component of the framework to address the following questions 1 segmentation during continuous experience what determines that one event is over and a new one has begun 2 encoding do we encode experience to memory momentbymoment or eventbyevent in chunks 3 representation once encoded how are dynamic events represented in the brain meme tackles these questions using a combination of innovative experimental designs including a largescale mobile game and tailored films created using the sims functional mri and intracranial recordings the stimuli crafted for the project together with an analysis approach supporting identification of temporal dynamics in fmri will make it possible to reveal the basic information unit byte of episodic memory storage only by identifying this basic unit will we be able to reach a comprehensive understanding of reallife episodic memory and its disorders the impact of meme will go beyond the realm of memory research because events are the fundamental units of experience that affect all our interaction with the world
film festivals and war a female perspective 1939present

a transdisciplinary project traversing cultural history film and film festival studies gender studies and digital humanities festwar fm will offer the first sustainable analysis of film festivals ff and war from a gender perspective despite numerous examples of womens involvement in wartime ffs no global study has yet analysed their roles in ffs in the context of ongoing wars nor theorised what we might learn from it the project will break new ground by investigating ffs evolution as places of memory in conflict situations with a specific focus on womens position within this process this will be done through three case studies connected to three armed conflicts that have occurred in europe since the creation of the worlds first ff in venice in 1932 wwii 19391945 yugoslavia 19911999 and ukraine 2014present the research will compare global responses to these wars through analysis of the worlds five most prestigious alist ffs venice cannes berlin toronto sundance with the european and local response of the major ffs operating in the war affected yugoslavia pula belgrade sarajevo and ukraine kyiv odesa the analysis will be organized around three categories cat cat1 women on the screen and behind the cameras cat2 women in decisionmaking structures cat3 women on the stage and the red carpet the project will produce a monograph two academic articles and an online digital archive oda including a a data visualisation chart b a selection of film extracts photographs and archival materials illustrating each case study and c a podcast with interviews with women engaged in analysed ffs during wars in yugoslavia and ukraine in doing so it will introduce a gendered innovation in the field of warrelated ff studies enable digitisation and digital distribution of knowledge data and sources and provide a public space for marginalised womens voices in line with the ec gender equality strategy 20202025
echo chambers online segregation mechanisms and consequences

the internet and social media dramatically transformed the news landscape the abundance of online news options recommendations of social media algorithms and changes in news production may have segregated individuals into echo chambers environments where people mostly consume likeminded news such echo chambers could exacerbate polarization distort perceptions of reality and threaten democracy however a gap remains between these grave concerns and the limited evidence on echo chambers a critical challenge is that research is typically conducted at the outlet level focusing on outlets rather than individual articles may underestimate segregation as individuals today consume specific articles from many outlets this project will analyze the demand and supply of news at the article level to provide new insights regarding the origins extent and implications of online echo chambers the project consists of three partsfirst i will create a new dataset of the slant political leaning of millions of articles using highresolution data expert ratings and advances in large language models i will use this dataset to provide the first estimate of online segregation based on the slant of articlessecond instead of fixing the set of articles and analyzing consumer behavior i will fix the audience and analyze how outlets tailor articles to their consumers and whether this increases segregation i will complement the descriptive estimates of how outlets distribute news with a casual analysis of whether the internet and social media affect the news that outlets producethird i will elicit individuals willingness to pay for various articles and causally estimate how the articles people typically avoid affect their attitudes when they are consumed i will use these estimates to decompose the relative importance of two theories for how news polarizes attitudes differences in preference for likeminded news and heterogeneity in the effects of news
a complementary approach to aromatic synthesis by dielsalder reactivity followed by desaturative photoredox cobalt and hat triple catalysis

aromatic molecules are integral to every aspect of chemistry in general the preparation of these compounds is approached via the use of aromatic precursors that are progressively functionalized using reactivity like electrophilicnucleophilic aromatic substitution derivatives equipped with electron withdrawing groups ester ketone are particularly used in synthesis but are often challenge to prepare this is because aromatic chemistry has to follow some stringent selectivity rules that activate or deactivate specific positions this means that installing a functionality on a deactivated position eg meta in an electron rich aromatic is very difficult and requires many stepsthis project seeks to address this challenge by developing an innovative approach to aromatic synthesis using simple dielsalder cycloadditions to construct a sixcarbon cyclic framework followed by an unprecedented desaturation process in particular we will demonstrate the integration of three catalytic modes photoredox cobalt hat catalysis as blueprint to progressively desaturate dielsalder cycloadduct to polyfunctionliased aromatics this reactivity will streamline the preparation of many highvalue but difficult to make aromatic products will be used in latestage functionalizations and will substantially expand the fields of dual photoredoxcobalt catalysis and boryl radical chemistrythis research capitalizes on recent developments of the leonori group that has experience in the development of methodologies based on both desaturation and boryl radical reactivity the completion of such an innovative and ambitious project at rwth aachen university will be facilitated by generating transferring sharing and disseminating knowledge and will enhance my future career following the training plan envisioned
improving the circularity of complex plastic multimaterial composites using novel biobased materials in b2b semifinished products

the general objective of cubic project is to improve the sustainability and circularity of complex products made of hightech advanced multimaterial composite thermoset and thermoplastic structures by developing novel circular biobased alternative materials cubic project designs novel materials biobased polyamide grades biobased endured 3rcanepoxy prepeg and biobased lignin derived carbon fibre to obtain circular by design 100 biobased and recyclable thermoplastic and thermoset b2b intermediate products subassemblies that permits to ecodesign complex products adapting their intrinsic characteristics to novel unconventional manufacturing processes as new paradigm to advance in mass production advanced products the novel approach on which cubic project relies is based on modularity or prefabrication the development of hightech biobased intermediate formats filaments sheets organosheets and udtapes pellets powder the smart combination of these intermediates into a final endproduct allows to overcome the current technical and environmental limitations to meet the demanding requirements of a specific sectorapplication where a single biobased material doesnt two endproducts or specific applications will be validated within cubic project type iv h2 gas storage pressure vessel automotive seat that satisfy the technical and environmental requirements the project demonstrates the demanufacturing recycling and valorization of the components toothe consortium consists of 13 partners with complementary competencies 6 industries sp com teq mos qplan as smes and nov as large company plus 6 rto partners ait ctb cid ide ditf cir and 1 academia lim to give support to the companies in the consortium and to develop the main scientific and technological activities in the work plan the undertaking involves 8 european countries es fr ie be dk de it gr the budget is 468711550 in a 42 months duration project
insight into drug distribution and local concentration using multispectral imaging of fluorescent drugs in inflammatory bowel diseases

inflammatory bowel diseases ibd are chronic relapsing inflammatory disorders of the gastrointestinal tract affecting 25 mil patients in europe alone the majority of newly diagnosed patients are in adolescence or early adulthood and in the midst of their family life career and social development though not lifethreatening the disease comes with significant morbidity and complex treatment strategies and is associated with a high social burden and medical costs msguide aims to revolutionize ibd treatment by offering highperformance insight into local drug distribution and concentrations that can lead personalized medicine in ibd patients and early drug development through identifying specific targeted cells of drugs elucidating the individual phenotype and thereby patient stratification this will be achieved by reinvigorating endoscopy to overcome major challenges for medical application the goal of msguide is to develop a highly sensitive novel imaging technology consisting of a nearinfrared fluorescence and reflectance multispectral imaging nirfrmi unit integrated into a never before seen highdefinition white light endoscope hdwle the aim is to quantify drug distribution and concentration and identify the individual drug target cells in the gut with this groundbreaking system we offer an operatorindependent endoscopic method to establish the optimal dose and to monitor the treatment response in ibd patients in realtime this will allow for an individual precise and quantitative diagnosis leading to a more personalized targeted and thus more effective treatment in ibd and common diseases in general