Dragon09/odtu_chatbot huggingface dataset:
fluidstructure interaction and machine leaning for controlling unruptured intracranial aneurysms

developing new capabilities to predict the risk of intracranial aneurysm rupture and to improve treatment outcomes in the followup of endovascular repair is of tremendous medical and societal interest both to support decisionmaking and assessment of treatment options by medical doctors and to improve the life quality and expectancy of patientsthe proposal aims at identifying and characterizing novel flowdeviator stent devices through a highfidelity computational framework that combines stateoftheart numerical methods for fluidstructure interaction modeling to accurately describe the mechanical exchanges between the blood flow the surrounding vessel tissue and the flowdeviator and deep reinforcement learning algorithms to identify and to invent a new stent concepts enabling patientspecific treatment via accurate adjustment of the functional parameters in the implanted state this has never been done before in this context and should thus open both new theoretical and numerical opportunitiescure takes the vital steps of bringing novel computational and optimization frameworks to the next level capable of studying the selected flow diverter treatment in order to reduce the risk of hemorrhage in cerebral aneurysms of supporting the decisions of treatment options by medical doctors and finally of providing guidance in the development of new implant design such unique capabilities can save millions of lives worldwide improve the life quality of patients eliminate lifelong sideeffects due to suboptimal treatment planning and delivery and reduce the tremendous societal and economic burden linked to poor patient outcomethe proposed work has potential to reshape the future of intracranial aneurysm risk management it is highly multidisciplinary and the methods proposed and developed as a part of this research can be quickly adapted to a wide range of engineering and biomedical applications
development of carbohydrate based anticancer agents

carbomed will assess the commercial viability of targeting cancer cell glycosylation as a nextgeneration therapeutic strategy to treat cancer in the clinic carbohydrates glycans coat the cell of every organism the glycosylation pattern of cancer cells is however very different from that of healthy cells and is associated with aggressive and invasive forms of cancers by combining our knowledge on carbohydrate chemistry and cancer immunology we targeted the cancercell protecting carbohydrate coat hampering the cancers ability to grow and metastasize in this project we aim to deliver a technical and commercial proofofconcept for targeting the glycosylation of cancer cells to ultimately enable clinical studies
unlocking the complex genomes of european potatoes for modern breeding

potato is one of the three most important food crops in the world around 13 billion people rely on potato as a staple food every day but despite this exceptional socioeconomic importance the improvement of potato during the past 150 years has been limited the main reason for this deficit is the highly heterozygous autotetraploid genome of potato this complicates several important aspects of breeding including the fixation of beneficial alleles and the implementation of modern genomicsassisted breeding techniquesrecently it has been suggested to convert tetraploid potato into a diploid crop and thereby overcome all the difficulties associated with tetraploid potato breeding however the creation of diploid potatoes is hampered by the large number of deleterious recessive mutations that have accumulated in the tetraploid genome and are exposed in the diploid potatoesin byte2bite we will address the fundamental issues that hold back the success of potato breeding we will generate the firstofitskind neartocomplete pangenome of potato and use this resource to develop unprecedented genomegraph tools for efficient genotyping and haplotyperesolved genome analysis we will then use this new computational toolbox to establish a genomicsassisted prebreeding programme in which we will generate novel potato cultivars with low mutational load this new resource will open the doors to efficient breeding unleashing the genetic potential of potato and thereby help to secure the way we feed the world for the decades to comespecifically in byte2bite we want to achieve the following goals 1a neartocomplete pangenome describing almost the entire haplotype diversity of potato2a genome graph tool for costefficient genotyping and haplotyperesolved genome analyses3a genomicsassisted prebreeding programme for potatoes with low mutational load
engineering homeostasis into living materials

engineered living materials elms are dynamically emerging at the intersection of synthetic biology and materials sciences and are providing solutions in a rapidly growing number of application fields current areas of application comprise for example biomedicine textiles sensors soft robotics electronics or construction materials from a conceptual point of view elms provide the opportunity of endowing materials with properties and functions long sought for in materials sciences such as adaptivity and interactivity evolvability hierarchical design selfreproduction energy harvesting from the environment synthesis from renewable resources as well as biodegradability despite intensive research however a key defining property of life is largely missing in elms that is homeostasis homeostasis is the ability of a system to maintain an inner steady state despite external fluctuations that impact this state for example mammals maintain a constant body temperature despite varying external temperatures in steady we will develop and test the concept of engineering homeostasis into living materials to this aim we will develop three genetically encoded modules i a sensor to sense the actual state of a specific mechanical property of the material ii a controller to process the sensor signal and iii an actuator that based on the controllers output steers the material towards the setpoint the design of the homeostatic system will be highly modular so that the sensor and actuator can be adapted in order to maintain homeostasis for other properties or functions of the material the tools developed here are not restricted to elms but may also be used to confer homeostasis to polymerbased soft materials with regard to maintaining a desired feature thus steady will open novel opportunities for engineering materials to be robust and resilient to changing environmental conditions
filmphilosophy as a meditation on death

film and death defends the hypothesis that to filmphilosophize is to learn to die this will be achieved by rethinking the innovations that film brings to recent philosophies of death and the metaphysics of time a new paradigm for understanding the relationship between film and philosophy is proposed that claims 1 that filmphilosophys methodology is a meditation on death and 2 that films think and have their own ways of creating novel thoughts that are not our own one of these thoughts concerns death a phenomenon of which we have no image but that film renders visible as a deathimage a direct image of passing time facing the impossibility of any representation we will assert that the cinematic experience is in itself equal to awareness of ones own mortality as a memento mori without which we would not philosophize at all the project has three key aims 1 to demonstrate that filmphilosophy contains significant philosophical insights 2 to show that such insights are best understood by means of films novel ways of thinking of time finitude and death and 3 to argue that films thinking about finite time gives new meaning to philosophys traditional role as a meditation on death to support this a new conceptual map for studying the ways in which death and time are linked through moving images is proposed the project will offer a contemporary view on death as a cultural phenomenon that has shaped twentiethcentury thinking in general and films in particular putting the usual anthropocentric definitions of death into perspective a timely undertaking given the evergrowing presence of film and moving media in our lives it will probe and question our own paradoxical existential condition as members of a thanatophobic society that rarely focuses on death in the everyday but discusses it readily when it is depicted in movies and tv
abnormal motherhoods precariousness sterility and anciery in 20th and 21st century spanish cinema

many depictions of motherhood in 20thcentury european media fall under what susan maushart described as the mask of motherhood 3 with this expression she refers to narratives that envision motherhood as healthy and unproblematic however since the last decade of the 20th century this situation has changed where maternity has become a controversial subject and discussions over issues such as ambivalence towards the child sterility and maternal stress are conspicuous in different media this is where the planned project which regards motherhood as a central question in gender studies picks up despite this increased visibility many maternal experiences do not fall under the category of normal in normative societal discourses and mothers affected by them are portrayed as ill or unfit abnormal motherhood encompasses practices that lie outside the limits of a norm previously established by hegemonic thinking and vice versa normality is what remains after establishing the edges of the abnormality huertas 26 taking spain as the main case of study i analyze 20th and 21stcentury films of motherchild relationships deemed abnormal and sick characterized by sterility poverty and anxiety in contrast to normal motherhood imagined as fertile healthy and unproblematic
efficient methanol from pumped heat and calcium looping

to achieve the 2050 climate goals industries must transition to zeroemission and circular processes crucial for the metallurgical industry facing challenges due to carbon dependence and difficult to abate emissions key to this transition is the integration of fluctuating renewable electricity sources circular processes and the production of versatile products like methanol however to overcome the challenges in emethanol production there is a need for technological breakthroughs for competitive renewable electricity and efficient co2 utilisation energyintensive sectors require lowcost environmentally friendly co2 capture systems the integration of powertovalue systems presents a unique opportunity for a seamless transition to circular economies emphatical targets residual coco2 containing gases from highly electrified metallurgical industry namely electrical and submerged arc furnace processes eaf saf through the energy efficient integration of innovative oxyblown calciumlooping capture technology purification and conversion of co2 to emethanol with green h2 as a feedstock culminating in a first of a kind trl7 demonstrator to establish economic viability and sustainability for achieving net zero in electrified metallurgical and methanol production emphatical will demonstrate integrated concept at relevant scale for making decisions for the foak taking overall conversion process from trl5 to demonstration trl7 the objective is to achieve a 25 reduction of the specific energy consumption and 25 decrease of the production costs in this project risks are mitigated from the start each unit can be implemented as a standalone function within a modified stateoftheart technology chain and thus provide immediate performance and energy efficiency improvements the project evaluates emphatical concept integration in two industrial sites the expected overall co2 reduction for emphatical plants is projected to be 41 mtyear by 2050
invasiveness and the microbiome gut microbial community dynamics in an invasivenative vertebrate system

biological invasions are one of the major threats to biodiversity worldwide due to the many impacts and rapid spread ofinvasive alien species ias however the exact mechanisms underlying invasiveness remain poorly understood ihypothesise that metagenomic plasticity may be involved in invasions ie ias may be able to quickly acclimate and adapt totheir new environment and oust native species thanks to the higher dynamism of their microbial community structure andorgene expression patterns i will study microbiome dynamics in two phylogeneticallyclose mammals a successful invadergrey squirrel sciurus carolinensis and a native species ousted by the former red squirrel sciurus vulgaris investigatingthe diverse interplay among their gut microbiome parasite infection dietary flexibility and behaviour individual personality iwill employ an observational approach in a natural experimental setting comparing variation in the microbiomephenomedynamics of the two species at both the individuallevel across seasons and populationlevel along a naturalurbangradient invasome will help disclose the mechanisms behind invasiveness and rapid adaptation of ias offering usefulinsights that may prove relevant for the prevention and management of biological invasions this project is highlymultidisciplinary and perfectly integrates several disciplines part of my skill set invasion ecology parasitology andbehavioural ecology with stateoftheart metagenomics in which i will receive advanced training by the proposed host whohas a relevant experience and an innovative and interdisciplinary approach to these fields i designed this project also toenhance my transferable skills making the most of the host institution initiatives i am thus confident that invasome will bothopen an underexplored line of research and at the same time greatly enhance my potential helping my transition to anindependent researcher position
a scalable semiconductor quantum computation platform based on ge hole spinqubits in rhombic quadruple quantum dots in strained gesige

i propose a 24month msca postdoctoral fellowship in experimental condensed matter physics to overcome limitations in coherence time singlegate operation frequency and scalable readout associated with challenges in realising quantum computers demeter builds on the complementarity of my strengths the leading fabrication expertise and infrastructure at my host tyndall national institute and the knowhow in quantum information processing afforded by a secondment at the highpotential uk sme quantum motion i will use ge as an emerging quantum material platform to realise gehole spin qubits in strained gesige heterostructures and gatedefined rqqds formed in the underlying ge demeter aims to demonstrate a beyond stateofthe art scalable qubit platform using the emergent architecture of rhombic quadruple quantum dots rqqds and the ge material platform using this novel architecture and exploiting advances in fabrication processes rfbased novel techniques that is rf singleelectron transistor rfset and gatebased sensing for qubit readout will be implemented offering scalability through integration of both the qubit realization and control readout my specific science and technology objectives are to achieve advances in the coherence time fast qubit operation and fast readout and to contribute towards the scalability of quantum microchips my career development will benefit from the supervision of dr giorgos fagas an established leader at tyndall the irish quantum technologies community and the eu landscape and the research expertise in processing ge nanostructures of drs duffy and petkov during my 2month secondment i will be supervised by dr fernando gonzalezzalba who is a leading researcher in gatebased sensing reflectometry the goal of the fellowship matches the urgent need to support the eu quantum technologies flagship and foster leading expertise in quantum computing
authentication and authorisation for research collaboration technical revision to enhance effectiveness

collaboration and sharing of resources is critical for research authentication and authorisation infrastructures aais play a key role in enabling federated interoperable access to resourcesthe aarc technical revision to enhance effectiveness aarc tree project takes the successful and globally recognised authentication and authorisation for research collaboration aarc model and its flagship outcome the aarc blueprint architecture bpa as the basis to drive the next phase of integration for research infrastructures expand federated access management to integrate usercentring technologies expand access to federated data and services authorisation consolidating existing capacities and avoiding fragmentation and unnecessary duplicationthe main objectives of the aarc tree project are toi capture and analyse new authentication and authorisation interoperability requirementsas emerging that support integration usecases across the thematic area andprovide a landscape analysis of aais services including gaps in the ris represented in aarc treeii define and validate new technical and policy guidelines for the aarc bpa that address ris usecases this will improve the integration of ris across thematic areas and increase the ability of ris to support emerging needsiii expand the number of research communities that can implement the aarc bpa andor the aarc guidelines by providing a validation environment and toolkits at the same time support existing aarc communities in adopting new guidelinesiv bring ris einfrastructures and relevant stakeholders together to align strategies to integrate new technologies better interoperate and share resources across thematic areas and produce a compendium and recommendations for different stakeholders
tuning tdp43 selfassembly to understand physiological function and dysfunction

neurodegenerative disorders are an enormous societal burden and we lack therapies that target these diseases at their origins to develop therapies we need to understand what goes wrong at the molecular level i uncovered key mechanisms that cause rnabinding proteins such as tdp43 to dysfunction and drive neurodegenerative processes i discovered that rnabinding proteins selfassemble into ribonucleoprotein granules that are the likely origins of rnabinding protein aggregates more recently my group and i revealed aberrant phase transitions of condensed rnabinding proteins occurring in disease and identified fundamental mechanisms by which such phase transitions are regulated in cellsin tdpassembly i now want to find out why these proteins exhibit a selfassembly behavior that apparently risks pathological aggregation my hypothesis is that selfassembly is essential for their many functions in gene regulation and that different types of selfassemblies eg small clusters or fluid or solid condensates mediate different functions in cells using tdp43 as a paradigm i will test this hypothesis to ultimately understand the molecular basis of rnabinding protein dysfunction in neurodegenerationto achieve this goal i will use synthetic biology approaches to rationally tune selfassembly of tdp43 in cells i will study how altered tdp43 selfassembly affects its known molecular functions ie regulation of transcription alternative splicing and translation transcriptome and proteome analyses will draw a systems biology map of altered tdp43 selfassembly and might lead us to novel functions of tdp43 selfassembly ultimately i will address how tdp43s selfassembly and thus its functions are altered by diseaselinked mutations in neuronal cellstdpassembly will forge a new understanding of the functional and pathological relevance of rnabinding protein selfassembly and might inspire new therapies that target selfassembly processes
equality diversity and inclusion for research enhancement in bosnia herzegovina

edire aims to create a networking collaboration between the university sarajevo school of science and technology ssst and four renowned research institutions in france italy ireland and spain with the final aim of increasing ssst research profile boosting its research capacity especially in the field of equality diversity and inclusion edi research on edi is almost totally unaddressed in ba therefore edire will contribute in introducing a new lines of research ssst in such strategic topics for the quality of research these transversal research areas will be embedded in an intensive set of training and networking actions addressing more in general ssst research and management capacity the project will rely for the achievement of such objectives on a variegated set of methods such as 1 interdisciplinarity and knowledge sharing 2 capacity building 3 participatory approach 4 inclusivity and sustainability and 5 farreaching methods for communication and engagement the twinning exercise will build on an appropriate set of key actions from joint training and research paths to bilateral meetings to short visits to dedicated conferences and summer schools leading to new research opportunities and joint research projects in the field the organization of networking and outreaching activities such as conferences dissemination events and liaison activities with similar projects will contribute to the visibility of ssst and of the other eu partners in the field an appropriate set of key actions will strengthen the research management and administrative skills of ssst staff and will lead to the establishment of a new research management unit at sssttransferability and uptake of outcomes and outputs and sustainability after the project enddate will be favoured by final recommendations and guidelines to policymakers and other institutions in widening countries
highfidelity quantum computing with carbon nanotubes

c12 quantum electronics builds reliable quantum processors powered by the most elementary material carbon nanotubes by utilizing singleelectron spins hosted in suspended ultraclean carbon nanotubes we achieve the closest realization of an ideal qubit in vacuum we integrate the nanotubes onto semiconductor chips thanks to our proprietary highthroughput technique any qubit can be coupled to any other qubit through a custom microwave resonator thereby we achieve scalable ultracoherent quantum processor architecture with isolated yet easily addressable qubits our carbon nanotube based technology can scale quantum computing in the vein of what silicon did for classical computing combining the purity of carbon nanotubes and wellestablished semiconductor manufacturing our innovation has the potential to process quantum information at large scales with the highest fidelity thus our quantum computers can solve complex problems beyond the reach of any classical supercomputer