Dragon09/odtu_chatbot huggingface dataset:
research action network for reducing reactive nitrogen losses from agricultural ecosystems

globally 5070 of the n fertilizer applied to cropping systems is lost as nitrate and noxides raising agricultural production costs and contributing to pollution and climate change these losses are directly linked to the nitrification process catalysed by soil nitrifying microbes the mitigation of reactive nitrogen nr loss via nitrification inhibitors nis is a promising solution for increasing n use efficiency nue in agriculture actionr aims to unravel the scientific excellence and innovation potential of a widening country greece through a european network of excellence on establishing novel tools and pathways for optimized nue reducing the continued acceleration of the n cycle and decreasing the environmental footprint of nr as a centre for greek agricultural production thessaly is suited to serve as a model for research on microbial n transformations for optimizing nue in agroecosystems but local capacity is not fully explored yet twinning of uth with two internationally leading partners in ecogenomics univie and microbial ecology ecl of the soil n cycle will i further develop research excellence of uth ii improve its networking efficiency and interdisciplinarity and iii have broad societal and environmental impact towards more efficient n management in agricultural settings these objectives will be achieved through the implementation of a welldesigned plan of training networking and disseminationcommunication activities including staff exchanges onsite training summer schools and symposia working groups on protocol unification integrated phd programs and outreach events directed towards potential stakeholders and local communities the expected impacts include an increase in scientific output and capacity building of uth the integration of sustainable nfertilization strategies at eu level in compliance with sdg eg sdg13 and 15 and the stimulation of public awareness on agrienvironmental issues
transformative pediatric brain cancer imaging using integrated biophysicsai molecular mri

despite vast drug development efforts brain tumors remain the leading cause of pediatric cancer deaths noninvasive monitoring of treatment response is crucial to reveal the mechanisms behind tumordrug interactions and optimize patient care however standard magnetic resonance imaging mri methods involve injecting metals have severe difficulties in differentiating treatment response from tumor progression are qualitative and mandate prolonged anesthesia due to the lengthy acquisition i propose to develop a transformative molecular mri technology based on the chemical exchange saturation transfer cest contrast mechanism that will enable specific quantitative rapid contrastmaterial free treatment monitoring of pediatric brain cancer recently i revealed that a combination of mathematical cest models and ai can generate quantitative biomarker maps of ph and protein concentration changes across the brain two known hallmarks of cancer inspired by these results i now propose to adopt a previously unconsidered perspective and to represent the underlying physics of cest mri as a computational graph enabling an automatic aibased optimization of molecular imaging i hypothesize that the combination of biophysical models with a new ai framework and their synergetic integration throughout the entire imaging pipeline will provide accurate noninvasive treatment monitoring first i will establish a method for automated optimization of mri protocols for early determination of the tumor response to mainstream chemotherapy next i will shorten the 3d scan time by an order of magnitude and quantify the response to next generation immunotherapy third i will translate the method to clinical scanners and validate it in a human pediatric pilot study this research will yield a fundamental understanding of the molecular mechanisms underlying treatment response and establish an innovative precision medicine methodology that will transform pediatric cancer imaging
cocreating actions to improve rationality in the health system

despite widespread recognition of social economic or environmental health determinants health action remains heavily dominated by individuallevel solutions eg medication patient counselling vaccination this proposal aims to stimulate changes in health system functioning by demonstrating how the cocreation of actions to address psychological wellbeing cardiovascular health and antimicrobial resistance from within the community can alleviate the burden on primary care services reduce medicalisation and increase health equitythe scientific approach uses mixed methods and incorporates theory from multiple disciplines we will appraise how the current system addresses psychological wellbeing cardiovascular health and rational use of antibiotics using a population survey a survey of patients collecting their medication at community pharmacies aggregate health service indicators on medication consumption and primary care consultations and qualitative methods exploring stakeholders perceptions we will undertake communitybased participatory research to engage citizen scientists in the cocreation of communityled actions to promote psychological wellbeing cardiovascular health and prevent antimicrobial resistance the design implementation and evaluation of the actions will apply an assetsbased approach and apply theories and frameworks from implementation science in an iterative manner over 3 years finally we will analyse the impact of the cocreated actions considering effectiveness and broader contextual issues such as initiative adoption implementation and maintenance this will use a beforeafter comparison of survey indicators an interrupted timeseries analysis of health service data and qualitative analysis the goal is to demonstrate how the integration of community action with attention to the social determinants of health can lead to a more rational approach to health care and ultimately improve health and health equity
bandresolved imaging and nonlinear optical control of currents in topological materials

topological materials have captured the imagination of scientists with unique electronic dispersions and surface states while their potential seems huge from advanced photodetectors to spintronic devices so far it has not come to fruition despite two decades of research in this proposal my aim is to reveal and control lightmatter interactions electron populations and currents in topological bands by combining two fields of research topological materials and nonlinear optical coherent controlnonlinear quantum coherent control was a major leap in ultrafast science enabling optical control of chemical reactions and electronic processes in atoms and molecules on femtosecond time scales in solidstate systems despite some pioneering experiments coherent control has not been widely used this is partially due to the complex band structures and partially because transport research has tended to be more easily applicable to the solidstate realm topological materials however are especially promising candidates for coherent control because a it has proven hard to access properties related to the topology in 3d materials via transport and b topological bands are associated with unique optical selection rules and as recently revealed fascinating nonlinear optical phenomenain this project i will develop nonlinear coherent control of photocurrents in topological materials thus building a bridge between nonlinear control to transport measurements of topological bands i will use timeresolved arpes a powerful tool providing bandimaging out of equilibrium to enable imaging of the photocurrents within the topological bandsphototopocurrent will establish a new research direction which will provide a deep understanding of the unique optical couplings and nonlinear optical responses of topological electronic bands allow us to develop sophisticated optical schemes for tailored control and finally implement them in transport devices
the emerging role of target of rapamycin in regulating the shadeinduced pathogen susceptibility in plants

in close proximity plants can sense each others presence via a decrease in the red to farred light ratio low rfr in the nearby surroundings low rfr perception by phytochrome photoreceptors triggers strong and rapid elongation growth allowing plants to grow taller than their neighbors and reach better lit areas this process known as shade avoidance is mostly orchestrated by the growth hormone auxin however although low rfr promotes elongation growth it compromises plant defense against pathogens by dampening defense hormone signaling a phenomenon referred to as shadeinduced susceptibility furthermore i recently found that plants exposed to low rfr conditions accumulate glucose which accelerates pathogen development in plants tissue yet the involvement of primary metabolism in regulating the shadeinduced susceptibility remains to be explored in eukaryotes the target of rapamycin tor kinase is a master growth regulator integrating the cell energy and carbohydrate status to regulate growth and defense responses in plants tor activity is promoted by auxin and glucose both strongly induced by low rfr interestingly i also found tor gene expression to be induced by low rfr in a recent rnaseq study in this project i will study if and how low rfr regulates tor signaling to promote growth at the expense of defence i will use genetic and chemical approaches to i identify the spatiotemporal dynamics of tor gene expression and tor protein activity in response to shade in the model plant arabidopsis thaliana ii identify the dependency of shadeinduced auxin levels and sugar accumulation on tor dynamics and iii characterize potential links between tor signaling and defense hormone signaling the gained insights will be instrumental for understanding how plants use shade signals to balance growth and defense responses and will help to engineer new pathogenresilient crop varieties which can be grown optimally at high densities
economic policies for the global bifurcation doctoral network

due to human activities at stake is the habitability of the planet and our capacity to invent effective inclusive and democratic trajectories that preserve or restore the viability of the planet to overcome the limits of mainstream economic paradigms epogdn aims to develop a community of economists able to work with other disciplines and a range of sectors and stakeholders to address these ecological challenges epogdn investigates the trajectories leading towards a strong sustainability ie scenarios considering social economic and ecological objectives as not substitutable to this end epogdn introduces the concept of global bifurcation gb defined as a series of processes which are systemic and multidimensional in nature to face the complexity of the gb epogdn proposes an original approach based on a a sociotechnical perspective and critical questioning of the role of innovation and technologies b a socioeconomic perspective involving the development of macroeconomic scenarios c a socioecological perspective to enable consideration of how social organisations and citizens can contribute to the gb d the interaction between these subfield to develop a systemic approachepogdn involves academic governmental and intergovernmental institutions local authorities ngos financial and nonfinancial corporations phds are jointly supervised by an economist and a supervisor from another field disciplines involved include economics sociology geography political sciences engineering life and earth sciences they benefit from international mobility in relation to their research at the institution of the joint supervisor and a secondment at a nonacademic partner the training includes collective activities and activities tailored to individual needs which cover interdisciplinary approaches and methods promote discussions with stakeholders from different fields and sectors and enhance transferable skills and professional development
beyond maximalism the role of domestic political institutions in the making and reception of excessive state claims

maximalist claims over territory and other goods abound in global politics yet we lack a basic understanding of what makes a claim maximalist what factors drive maximalist claims and how they can be countered while russian claims concerning ukraines foreign policy and territorial integrity as well as chinese claims to the entirety of the south china sea strike most citizens analysts and policymakers as maximalist the conceptual distinctions between such claims and other more ordinary claims have not been made in the international relations or law scholarships lacking a conceptual basis we also do not know much about how to study the causes and consequences of maximalist claims this project is a valuable first step in the direction of analytically rigorous and policyrelevant studies on excessive claims and ways to counter them the proposed research defines maximalist claims as those that ostensibly go beyond the relevant rules of international law and claims made by other states it aims to collect original data on all maximalist territorial and maritime claims in the postworld war ii period bridging comparative politics and international security scholarship it will formulate and test hypotheses linking domestic political institutions with the making and reception of maximalist claims moreover it will seek to adduce experimental evidence to the mechanisms underlying perceptions of maximalism and formulation of appropriate responses throughout the main objective of the project will be to understand how regime type influences interactions over maximalist claims involving both states and international organizations this contribution is particularly timely given the rise of authoritarian regimes and authoritarian tendencies even in otherwise established democracies supported by robust communication and dissemination activities these studies will advance the scholarship on multiple fronts and provide valuable input for policymaking processes
quantum secure networks partnership

the quantum secure networks partnership qsnp project aims at creating a sustainable european ecosystem in quantum cryptography and communication a majority of its partners which include worldleading academic groups research and technology organizations rtos quantum component and system spinoffs cybersecurity providers integrators and telecommunication operators were members of the european quantum flagship projects civiq uniqorn and qrange qsnp thus gathers the knowhow and expertise from all technology development phases ranging from innovative designs to development of prototypes for field trials qsnp is structured around three main science and technology st pillars the first two pillars next generation protocols and integration focus on frontier research and innovation led mostly by academic partners and rtos the third st pillar use cases and applications aims at expanding the industrial and economic impact of qsn technologies and is mostly driven by companies in order to achieve the specific objectives within each pillar and ensure that knowhow transfer and synergy between them are coherent and effective qsnp has established st activities corresponding to the three main layers of the technology value chain components and systems networks and cryptography and security this framework will allow achieving the ultimate objective of developing quantum communication technology for critical european infrastructures such as euroqci as well as for the private information and communication technology ict sectors qsnp will contribute to the european sovereignty in quantum technology for cybersecurity additionally it will generate significant economic benefits to the whole society including training new generations of scientists and engineers as well as creating hightech jobs in the rapidly growing quantum industry
pats eliminating pesticides

pats provides a fully automatic insect control solution which combines automated monitoring and ai solutions with high control methods such as batlike hunt drones and ultrasonic predatorprey confusionour vision is to revolutionize agriculture by combining biology with technology we offer an ecosystem of innovative solutions designed to enable organic farming and significantly reduce insecticide usage by integrating biological control with our technological methods we aim to cut insecticides by 75 and achieve a 10 reduction by 2030our control methods effectively tackle hardtomanage pests that previously necessitated insecticides the collateral damage from these chemicals disrupts biological control not just for these pests but also for others our automated monitoring provides precise data on flying pests natural predators and pollinators this granular data empowers farmers to optimize biological control improving its efficiency and making it a sustainable choice
an integrated typologybased approach to guide the future development of european historic buildings towards a clean energy transition

the process of future proofing the built heritage faces the paradox of needing standardised approaches but having a heterogeneous stock with very specific needs futurhist will rely on the identification and characterisation of local uniform building typologies as a lowest common denominator to develop tailored intervention approaches that can be standardised and replicated in all buildings of that category with minor modifications the standardised approach will then serve as a basis for the adaptation to other typologies in the same context climate regulations etc or even similar typologies in terms of materials configuration etc in different contextsalthough considerable progress has been done in recent years in terms of development of materials and solutions compatible with conservation of historic buildings several challenges remain still open futurhist will develop both passive and active solutions with a focus on an efficient use of energy and resources improved wellbeing enhanced durability revalorization of existing materials and techniques integration of renewable energy systems and smart solutions for decarbonising heating cooling and ventilation mentioned here just as examples be a claybiocharinsulation selfhealing lime plaster and hybrid originalvacuum glazingdemonstration is at the core of the project the solutions developed as well as the approach will be implemented and tested in four cases in spain poland sweden and the uk the diversity and geographical distribution of the demo cases will ensure the validation under different climates construction typologies and socioeconomic environments the demo case owners as members of the consortium will facilitate a rapid uptake of the results to be implemented in their large portfolios immediately after the completion of the project moreover the involvement of heritage authorities and partnership with icomos and intbau will ensure trust and widespread replication
subcutaneous delivery of theranostic cellbased therapies

this poc project seeks to develop a simpletoimplement selfassembled and injectable hydrogel material for the controlled codelivery of our similicar nk cells and stimulatory cytokines to improves treatment of both solid and liquid tumors similar to biologics delivery where monoclonal antibodies mabs are commonly administered by iv infusion due to regulatory criteria favoring such route which had limited confounding factors the iv administration remains responsible for some over costs and clinical challenges including the need for dedicated infusion facilities aseptic preparation of required infusion batches extended infusion times potential difficulties and risks with iv catheter the subcutaneous sc administration is deemed to overcome many of these challenges and might appear as an attractive alternative to the iv administration in addition the sc route used for mab administration was received with an overwhelming preference according to patients despite limited and reversible local adverse events induced by the rhuph20 alternative solutions are being evaluated through clinical trials such as the direct sc injection of mabs without recombinant human hyaluronidase or using novel enzymes but none are currently being clinicallydeveloped for cellular therapies moreover those alternative sc methods induced large pharmacokinetic heterogeneity between patients confirming the need to develop novel alternative approaches to accelerate the development of sc mabs formulation hence in parallel to the biological approach chemistrybased approaches such as hydrogels have been proposed however to date none of them successfully managed to be translated to the clinic this can be explained by the absence of full biodegradability after injection orand potential poor biocompatibility inducing inflammatory responses here we sought to develop a novel formulation of functionalizedchitosans for controlled release of modified nk cells
accelerate positive clean energy districts

ascend accelerate positive clean energy districts seeks to accelerate the implementation of positive clean energy districts pced for cities transition toward climate neutrality and social justice across europe ascend will deliver two inclusive affordable pceds in lyon and munich
hierarchical porous peek via combined physical foaming and additive manufacturing bringing circularity to advanced engineering materials

a number of engineering applications require lightweight structural materials providing a good combination of stiffness toughness and strength including transportation buildings and energy storage and conversion fibre reinforced polymers frp in the form of monolithic and sandwich structures are nowadays mostly used in lightweight aerospace applications however frps present an intrinsic sustainability hotspot given the difficulty on their recycling high performance thermoplastic cellular solids hptc are excellent candidates for those applications requiring a compromise between mechanical and functional properties ensuring at the same time recyclability by using thermoplastic polymers the main intrinsic advantage of cellular solids is the ability to tailor their properties by tuning the microstructure cell size wallthickness and distribution however conventional foaming techniques such batch foaming extrusion foaming or foam injection moulding do not allow for precise control of the obtained cellular morphology production of cell size gradient or the manufacturing of hierarchical macromicroporous structureshippeek aims at developing a processing strategy towards the manufacturing of porous materials of small controlled and graded cell size and shape through additive manufacturing am focusing on polyetheretherketone peek peek is a highperformance engineering thermoplastic with high strength to weight ratio reported as an excellent candidate for metal replacement in a variety of applications including space aerospace automotive medical and dental functionally graded porous peek will be accomplished by the combination of environmentally friendly physical foaming with inert gases with the production of threedimensional scaffolds through resource efficient am which will allow the production of controlled multiscale hierarchical structures on the micro and meso scales together with optimized topology at the macro scale