Dragon09/odtu_chatbot huggingface dataset:
healthy microbiota avoiding fractures during ageing

the basic research problem gradual loss of bone and muscle mass with ageing leads to increased risk of fractures in the elderly population there is a large medical need for new fracture preventive therapies with minimal side effects and novel biomarkers that improve the prediction of fracture risk the aim of the proposed research is to test our hypothesis that the increased fracture risk in elderly people is caused by an agedependent unhealthy change of the gut microbiota gm composition resulting in reduced bone and muscle mass and thereby increased fracture risk methodology we will identify agedependent gm signatures that are causally associated with reduced bone and muscle mass and thereby increased fracture risk in elderly subjects a major emphasis will be to determine causality of the gm using a variety of recently developed gmrelated genetic instruments for gm composition and function as well as for circulating metabolites as exposures in 2sample mendelian randomization mr in addition we will use faecal microbiota transplantation fmt to directly determine causality of agedependent gm alterations for reductions in bone and muscle mass based on this information we will design candidate probiotic treatments and test their efficacy in mouse osteoporosis models finally we will determine the clinical usefulness of the identified gm signatures for fracture prediction in elderly subjectsresearch progress beyond the state of the art we will employ three complementary methods 2sample mr fmt and treatment studies to determine causality for gm on musculoskeletal parameters for this research we have established large wellcharacterized nordic cohorts with metagenome sequence data and information on incident fractures available in 2023 identification of a gmsignature with a robust effect on agerelated bone and muscle loss will openup completely new avenues to avoid fractures in elderly
generation validation and use of a synthetic reporter of car t cell products function and dysfunction

cellbased immunotherapy particularly adoptive cell transfer act using engineered t cells holds great promise as a therapeutic strategy for cancer treatment however challenges such as the manufacturing process excessive antigen exposure and the hostile tumor microenvironment often lead to dysfunctional t cell products limiting their effectiveness in treating both blood cancers and solid tumors we propose a novel tool to define in vitro conditions to enhance t cell product fitness through the development of a synthetic reporter system for detecting t cell dysfunction states referred to as synt this innovative system will incorporate a dual synthetic locus control region slcr reporter with one slcr reporter indicating t cells in a potent serial killer mode and another slcr reporter representing t cell dysfunction by using synt we aim to screen for external signaling and pharmacological modulators that can enrich and reverse the dysfunctional state in car t cells we will generate and validate a synthetic reporter of car t cell products function and dysfunction and produce a media supplement that promotes act products functions
zagora sustainable hydrogen region

stara zagora is a strategic logistic centre in bulgaria and the balkan peninsula it is also host to one of the biggest power production complexes in europe maritsa east this makes it the perfect location to showcase the versatility and potential of green hydrogen as means to improve air quality in the city reduce co2 emissions for energy production and mobility applications and generate economic welfare the demonstration of clean safe and sustainable hydrogen technology applications will improve public perception of hydrogen ecosystems and kick start a hydrogenbased economy not only in the region but across the countryzahyr will install and demonstrate two electrolysers with a combined installed power of 5mw to be run on green electricity produced in a new 20mw pv plant the hydrogen produced will be used in various transport and energy applications these include the installation of two hydrogen refuelling stations to service a fleet of 10 city buses 2 heavy transport trucks and 2 lightduty vehicles a bifuel gas turbine will be installed in which blending limits between hydrogen and natural gas will be tested a 1mw fuel cell at stara zagora will provide the municipalitys public night lighting showcasing how this municipality can become net zero emission finally a broad training and education program will be set up resulting in a masters degree an intense replicability activity will be carried out based on the organization of the hydrogen valley development group
signalenhanced mri contrast agents for neurodegeneration

despite decades of research neurodegenerative diseases remain challenging to diagnose and identify on time at the point external symptoms such as memory or motor deficits become evident the patient has usually suffered irreparable neuronal damage this not only decreases life quality and expectancy of the patient but also severely limits our ability to design new effective treatments and apply existing ones in a timely manner a promising approach for early diagnosis could be the visualisation of metabolic changes in the brain there are specific differences in the points of origin for different neurodegenerative diseases the fact that the metabolism of neurons change when they are exposed to internal or external stressors makes detecting changes in the metabolism of specific brain regions in comparison to the rest of the organ a possible powerful tool to early diagnose the onset of neurodegeneration during the course of my erc starting grant my team and i have developed new magnetic resonance technologies and contrast agents based on body own metabolites these metabolic contrast agents can not only visualize overall metabolism of observed tissues but also show differences in the rate of resulting metabolites further increasing the potential diagnostic accuracy before the developments made in my erc project especially a fast and simple approach to obtain such contrast agents was out of reach in first experiments we provided evidence that my approach can be used to detect the onsets of parkinsons disease one severe neurodegenerative illnesswith the project outlined in this poc we now aim to determine the feasibility of our technology as a clinical solution and a business opportunity to enable timely straight forward fast and noninvasive diagnosis for neurodegenerative diseases the success of this project will be the first important step to bring our technology into the clinics and improve patients health on a global scale in the future
driving agroecological transitions in the humid tropics of central and eastern africa through transdisciplinary agroecology living labs canalls

the humid tropics of central and eastern africa hold much promise for enhancing food and nutritional security within and beyond africa with a rich variety of agroecological zones and diverse farming systems they are home for a great part of the rural population and a large diversity of living organisms offering vital ecosystem services and potential for sustainable development still if we are to tap into this potential we need to address the complex environmental social and economic challenges they face which in cases are exacerbated by conflict and high vulnerability in this context canalls aims to drive agroecological transitions in the humid tropics of central and eastern africa via multiactor transdisciplinary agroecology living labs alls we start with 8 alls in drc burundi cameroon and rwanda working alongside and enabling over 20000 farmers and value chain actors to cocreate and benefit from optimal combinations of agroecological practices focusing on crops that are vital for subsistence and economic development cocoa coffee cassava rice maize in parallel we engage in solid multiactor collaboration with rural communities advisory services and governments to develop a holistic assessment framework and evaluate the socioeconomic and environmental performance of the cocreated practices accounting for tradeoffs and synergies we use the comprehensive evidence generated to build capacity and share knowledge practice abstracts replication guidelines policy recommendations as well as to deliver fair inclusive and sustainable business models along with services and tools for facilitating access to markets and enhancing demand for agroecological products our vision is to create a growing network of alls that leverages euau cooperation to conduct transdisciplinary research offer scientific support and drive coordinated action for delivering holistic solutions that help shape enabling conditions for agroecological transitions
design and creation of a yeast platform for synthesis of chiral amines by enzymatic cascades

the development of green and robust technologies for the conversion of renewable feedstock into highvalue chemicals is of great interest and challenging for the chemical industry although lamino acids can be sustainably produced from renewable feedstock by fermentation these amino acids are rarely being used as starting material for the chemical synthesis of highvalue chiral molecules due to the lack of efficient and highly selective biocatalytic methodologies in this project i will design and develop a modular approach for biocatalysis in vivo enabling the conversion of natural amino acids into enantiopure alphachiral amines and aminoalcohols which are important intermediates or final products for the pharmaceutical agrochemical and fine chemical industries saccharomyces cerevisiae will be selected as the host organism for the biocatalytic pathway because its genome is wellknown is suitable for large scale operation and will allow to obtain higher productivity than using bacterial strains a library of integrative plasmids expressing the enzymes will be constructed and transformed to s cerevisiae to obtain a yeast cell factory the system will be optimized both on the genetic level and on the bioprocess level the working plan will include an interdisciplinary approach involving molecular biology techniques together with metabolic engineering as well as optimization of conditions for biotransformation additionally analytical chemistry methodologies for determination of yield purity and enantiomeric excess of the products and intermediates will be required while the stateoftheart proves the feasibility of the project by using our proposed approach with resting s cerevisiae cells we expect to make a major breakthrough in the field in terms of increase productivity eg spaceyield spacetimeyield total yields from substrate and moreover a wider applicability of the resulting platform due to the modularity approach
rescue pacing for congenital complete heart block

congenital heart block is the most commonly observed type of foetal bradycardia occurring in one in 15000 live births a significant subset of foetuses develops towards congenital complete heart block cchb ie complete failure of the electrical excitation wavefront to be conducted over the atrioventricular av node cchb is the most severe and lifethreatening cardiac arrhythmia in utero current medicinal treatments cannot significantly alter the cause of cchb and therapeutic attempts at human foetal cardiac pacing have been unsuccessful for cchb patients at high risk for lifethreatening disease progression and death due to severe bradycardia before 34 weeks of gestation this project develops a gene therapy medicinal product gtmp that is based on adenoviral vectormediated ion channel overexpression to transiently increase heart rates over the course of several months when successful such a gtmp would rescue these patients and allow for permanent pacemaker implantation in the first months after birth
unveiling the nature of superconductivity in moir quantum matter

graphene moir materials constitute a new paradigm in condensed matter physics for the study of superconductivity and other collective electronic phases given their chemical and structural simplicity as well as large tunability as compared to other manybody systems however a comprehensive picture of the fundamental properties of superconductivity in graphene moir materials is still missing due to the limited information attained so far at the microscopic level therefore the need for local probe techniques that enable the exploration of superconductivity in moir matter with outstanding energy and spatial resolution is pressing and constitutes the main motivation of this projectthe ultimate objective of this project is to unveil the microscopic mechanisms driving superconductivity in graphene moir materials to this end i propose the local characterization of the superconductivity in various twisted graphene systems with unprecedented resolution few ev by means of stmsts measurements at milikelvin temperatures here i aim to unveil i the symmetry of the order parameters in unambiguous connection with the valley orbital and spin degrees of freedom ii the origins of the attractive interactions governing cooper pairing and iii the nature of the neighboring correlated phases as well as their interplay with the superconducting state the intellectual merit of this project lies in the fact that will provide groundbreaking insights to longstanding questions in condensed matter physics initially posed in complex unconventional superconductors here instead tackled using simple highly tunable moir materials furthermore this project has the potential to unveil forms of superconductivity never seen in nature before by using stateoftheart microscopy technology that combines atomicscale spatial resolution with the finest energy resolution
micromacro secure control of infinitedimensional transport systems

although transport may imply different notions for different scientific fields the feature of incorporation of interacting system components through which information is propagated remains invariant biological transport systems is an example whose significance has become evident with the recent outbreak of covid19 spreading blood transport in cardiovascular systems falls also under this category the urgent need of design of efficientsafe epidemics spreading suppression and congested blood transport monitoring strategies is apparent considering the potential significant socioeconomic impact however the continuum spatiotemporallyvarying nature of such interconnected systems in addition to dynamic complexity and limited available control authority hamper development of systematic feedback control design and analysis methodologies cnora aims at introduction of a pioneering holistic framework for systematic computationally tractable control design and analysis of largescale interacting distributed parameter transport systems which i harmonizes control at micromacro levels ii accounts in design for all essential dynamic phenomena iii compensates adverse effects of limited control authority in design and iv develops ad hoc tools for systemspecific analysis cnora new control design and analysis tools will be demonstrated in distributed parameter epidemiologicalcardiovascular transport systems and will be validated in numerical simulation cnora high risk lies in unification and complexity of heterogenous unexplored infinitedimensional systems whose treatment requires rethinking of fundamental controltheoretic tools cnora high scientific gain lies in that on the way of executing its key ideas novel interdisciplinary concepts and groundbreaking controlanalysis methodologies will be introduced while unprecedented research arenas will open for systems and control transport mathematicians and systems biologists
driving manufacturing sme transformation towards green digital and social sustainability

manufacturing is among the key driving forces of the european economy and their engagement is a must to achieve green deal goals greensme project aims to drive manufacturing sme towards green digital and social sustainability to achieve this main goal the project will strength sme capacity for advanced technologies adoption to become competitive and climate neutral maximising the benefits for all parts of society this vision implies smes to develop a strategic approach to sustainability the project vision eu manufacturing industry sustainability shift will be achieved through greensme hub which gathers sustainability awareness and industry engagement activities ecosystem networking space and tailored advisory services to smes through the sme sustainability transformation pathway the greensme hub will become a knowledge sharing area that gathers resources activities and stakeholders to enable the uptake of at by smes for sustainability sme sustainability transformation pathway the pathway gathers the whole process of guidance that will be given to the smes for their shift towards sustainabilitythe smes that have developed a greensme sustainability assessment will be eligible to apply for financial support the project will dedicate a budget of 3 meuros for supporting smes in the implementation of the sustainability strategy action plansgreensme project is firmly committed with open science policy and project exploitable result will be shared and disseminated project main outcomes are 1 eu manufacturing sme sustainability roadmap 2 greensme hub a knowledge sharing community that gathers manufacturing ecosystem stakeholders and all the developed sustainability communication material within the project 3 greensme sustainability assessment tool and advanced sustainability action plan asap definition methodologyand 4 sme sustainable pathway and at implementation good practices white book
dealing with a resurgent china

this consortium recognises the resurgence of china as a top tier great power is changing the world and the eu needs to develop a longterm approach based on knowledge to engage strategically with the resurgent and increasingly assertive china as well as the global changes unleashed thereby including the process of selective decoupling and persistent uschina tension to assist this this consortium will bring together some of the best researchers across seven countries to work in a synergetic way to build up a world class independent knowledge base on china in europe we will do so by engaging in critical scientific research nurturing a generation of younger scholars and building up a collaborative network that endures the key subjects we will address will cover all the key areas identified in the horizon call namely society and culture politics economy and foreign policy furthermore this consortium will prioritise impact and dissemination for the eu the corporate world the media and the wider public across europe the building up of independent knowledge on a resurgent china will enable the eu to better deal with it
locating intergenerational ties rematriating late19thcentury unpublished photographs of smi women and children

employing a decolonial approach inspired by critical museology and indigenous studies lit aims to initiate a visual restitutionrematriation process fostering attention to smi peoples experiences during colonial encounters and to illuminate individual lifestories of women and children photographed by italian anthropologists mantegazza and sommier between 1879 and 1886 it wishes to generate dialogical knowledge of unpublished visualwritten materials enabling smi communities of interest to gain access to these scholars photographs in complex sociohistorical indigenoussettler contexts such as spmi the smi homeland smi peoples control over their own heritage has proved essential to processes of cultural and ethnopolitical selfdetermination part of the smi visual heritage consists of photographs taken often through mild violence and coercion by academics engaged in physical anthropological practices involving smi individuals of all ages and genders the resulting academic and divulgative publications circulated in europe for decades shaping and reinforcing stereotypes of smi peoples and cultures photos taken in colonial encounters by late19thearly20th century scholars to visualize smi peoples supposed biologicalcultural inferiority until a few decades ago inaccessible to the smi have become important means of decolonization and empowerment through art and activism the visual restitution of such photographs is of the utmost importance not only from a cultural heritage perspective but is also considered by smi institutions and individuals as an urgent necessity lit proposes an innovative approach based on the coconstruction of knowledge and with a gender dimension i shall reconstruct life stories of women and children photographed by italian ethnologists locating their descendants and returning their photographs to their communities lit would benefit my career making me a leading researcher in sami studies and museology
innovative modelbased plasma algorithms for control of spherical tokamaks

the huge mass of a star and its associated gravitational forces make the nuclei of hydrogen atoms collide and fuse releasing energy in the form of energetic neutrons this process called nuclear fusion has a very high energy density and does not produce co2 or longlived radioactive waste for these reasons nuclear fusion has attracted the attention of scientists since the 1950s who have tried to reproduce the conditions of a star in their laboratories so far tokamaks are the most promising prototype for a nuclearfusion power plant on earth in particular spherical tokamaks provide an attractive configuration due to their compactness and lower cost than conventional tokamaks this would provide a means to mitigate the actual climate and energy crisis using nuclear fusion to complement other renewable energies in a greener futurecontrol of the tokamak plant and associated systems whose final goal is to confine a plasma by means of magnetic fields is critical to attain the necessary conditions for nuclear fusion to happen however plasma control in spherical tokamaks requires specific solutions due to their challenging plasma shapes and pressures which often trigger plasma instabilities under the marie sklodowskacurie actions the impact project innovative modelbased plasma algorithms for control of spherical tokamaks will design a stateoftheart plasmacontrol system for spherical tokamaks and will deploy it on the small aspect ratio tokamak smart under this project novel algorithms based on plasma dynamical models will be developed to tackle the newest control challenges in spherical tokamaks including negative triangularity plasma shaping to enable higher plasma confinement and ensure safety of the tokamak reactor this project will ensure the realization and sustainment of the plasmas needed in smart thus enabling and accelerating its scientific and technological mission to make nuclear fusion a reality