Dragon09/odtu_chatbot huggingface dataset:
mitigating environmental disruptive events using peoplecentric predictive digital technologies to improve disaster and climate resilience

despite digital predicative systems improving our ability to foresee the impact of disruptive climate events on our cities the complexity of these environments coupled with the lack of data to assess the impacts of such events leaves large swathes of urban areas exposed to future events these conditions are exacerbated by climate change growing urban populations and vulnerable illequipped building stocks designed for a shifting climate thus not guaranteeing occupants safety and resilience of the interconnected built environment minority report will develop and implement a cocreation framework to support the delivery of a peoplecentric technology platform integrating 1 innovative predictive digital technologies 2 rigorous models 3 for risk including vulnerability and uncertainty assessment and categorisation 3 advanced weather forecasting and early warning for climate events 4 bim digital twins monitoring systems and dss 5 energy simulations and behavioural models based on ai including evacuation models 6 newly developed approaches from ssh 20 cocreation events 7 and deep renovation passports 3 efficiently combining 10 deep retrofit solutions the final objective is to deliver the minority report technology platform for a functionally sustainable circular value chain for construction and renovation of built environments for improved climate change mitigation heat waves category 5 storms wildfire and disaster resilience floods earthquakes etc through unprecedented environmental targets 70 energy savings 30 carbon footprint reductions 60 environmental impact reduction minority report will apply its universal cocreation framework across three demo sites representing three distinct climatic areas situated in eu and the indopacific dublin ie patras gr wellington nz these demo sites share both common and local environmental and societal challenges which enriches the proposals scope and scalability
dynamic cell wall remodeling during plantmicrobe interaction

plants have a strong yet extensible wall as their outermost layer which is indispensable for the survival of the cell and permits cell adhesion the plant cell wall cw plays an essential role in response to biotic stress as it constitutes the first contact substrate for microbes our findings using the model pathosystem consisting of the plant arabidopsis thaliana and a root pathogen that can infect it fusarium oxysporum fo confirm that the plant cw is not the static barrier it has been seen as until recently on the contrary based on our preliminary data we hypothesize that plant cw remodeling at the subcellular level plays an essential role in the outcome of the plantmicrobe interaction which might explain the sophisticated mechanisms of plantendophyte pathogen neutral or beneficial coevolution our work has established a foundation of tools that provide a timely and unprecedented opportunity to test this idea we aim to elucidate the role of rootspecific cw composition and its dynamic changes in rootfo interaction then we will use this knowledge to modulate the cw properties of the root cell layers to reduce fo pathogenesis while maintaining beneficial endophytism through a unique combination of wellestablished and highriskhighgain molecular biochemical bioimaging and genetics approaches this project will provide groundbreaking insights not only into the molecular mechanisms underlying cwdependent establishment and regulation of innate immune signaling in plants but also into general mechanisms that control plantmicrobe interaction outside the plasma membranes the knowledge gained from this work will advance our current understanding of plantmicrobe coevolution in addition we will generate innovative methodologies that will be applicable in designing strategies to reduce damage caused by vascular pathogens in crops
understanding local adaptations to marine heatwaves

marine heatwaves mhws are prolonged extreme oceanic warm water events which can have devastating impacts on coastal ecosystems the observed and projected future increase in mhws intensity and frequency is a growing threat for island societies that strongly depend on oceanic conditions and resources mhws cannot be prevented but their socioeconomic impacts could be limited with sustainable adaptation strategies such adaptation will only be efficient if guided by inclusive placebased but scalable knowledge on the vulnerability of different groups of coastal resource users i will use the theory of gender equity and social inclusion to develop a comprehensive understanding of values for nature natures contributions to people ncp and anthropogenic capitals to support sustainable climate change adaptation mhwadapt has three objectives to 1 understand the relationship between decisions regarding adaptations and values for nature and ncp 2 identify and characterise the anthropogenic capitals that underpin coastal resource users decisions and 3 to gain indepth knowledge of the feedback loops between values for nature anthropogenic capitals and ncp coproduction with climate change adaptation mhwadapt differs from existing approaches that concentrate on topdown or natural science based approaches to climate change adaptation which overlook that social and ecological outcomes are interdependent and cannot be understood separately using novel methods eg photovoice participatory gis in study areas in new caledonia and fiji i will develop placebased yet scalable scientific and transformative knowledge the implementation of mhwadapt will draw on my skills in social science and the hosts research excellence on mhws including their ongoing fieldwork in my study regions this setup ensures a theoretical and empirical foundation for my research and a forum for communicating my results to nonacademic actors in the south pacific and europe
future hydrogen assisted gas turbines for effective carbon capture integration

the achievement of the eu targets established for 2030 for a more sustainable costeffective and environmentallyneutral energy production will not only require increasing the penetration of renewable energy sources res into the actual mix but necessarily point to reduce the carbon footprint of the conventional technologies based on the use of natural gas which is required to complement and compensate intermittent availability of res transition objective is to pave the way for carbonneutral energy generation from natural gasfired power plants using gas turbines gt by enabling a highly efficient carbon capture and storage ccs process in the postcombustion phase this will be achieved by the development of advanced hydrogen assisted combustion technologies capable to permit stable engine operations with high exhaust gas recirculation egr rates leading to high co2 content in the exhaust gas sent to the ccs unit two distinct scenarios will be considered by i validating up to trl4 retrofit hydrogenbased burners targeting 50 egr rate and ii proving up to trl 3 more aggressive technologies adopting hydrogenoxygen flame piloting to reach 60 egr experimental tests from atmospheric up to fullengine pressure will support the technology assessment and the validation of highfidelity numerical cfd models overall ccsgt system integration will be also carried out with technical and economic analysis the global sustainability of the proposed technologies will also be investigated to assess environmentalsocialeconomic impactstransition outcomes will enable the decarbonisation of gtbased power plants which are among the most efficient energy thermal generators adopted in several energyintensive applications the multifuel capabilities and the retrofit opportunity of the developed systems will allow targeting hardtodecarbonize sectors enabling an efficient transition to a net greenhouse gas neutral eu economy
neural stem cell coordination a developmental evolutionary and circuit perspective

the adult mammalian brain exhibits a remarkable capacity of adaptation which has long been thought to result from synaptic remodeling of neurons born during development importantly the discovery that new neurons can be generated in the adult by neural stem cells nscs revolutionized our understanding of brain plasticity in the adult mouse brain nscs reside in two specialized niches the dentate gyrus dg and the ventricularsubventricular zone vsvz lining the lateral ventricles although anatomically and functionally different these two neurogenic regions share several cell types including the glial nscs and their lineage and are sensitive to similar environmental stimuli this raises the exciting possibility that nscs within and between niches could coordinate their behavior under specific contexts i recently showed that in the vsvz regionallydistinct nsc pools can selectively and transiently respond to specific physiological states however such spatial and functional stem cell diversity in the dg remains to be investigatedhere we hypothesize that the two brain niches form a single plasticitygenerator system comprising multiple stem cell subpopulations some of which may be interdependent we will first investigate whether some nsc pools across both niches share unexpected molecular features and developmental trajectories to determine whether and how this vsvzdg system evolved to sustain a plasticityoriented regionallyrestricted and transient process in mammals we will perform comparative transcriptomics with a contrasting model of adult neurogenesis in zebrafish which is regenerationoriented widespread and continuous finally we will test whether the recruitment of specific adult nscs in the mammalian brain is orchestrated by neuronal circuit activity outside the nichealtogether our work will uncover the molecular cellular and circuit logic of adult mammalian neurogenesis in light of nsc heterogeneous identities
unraveling the functional complexity of cancer genomes through chromosome engineering

cancers arise through genetic and epigenetic alterations that drive the transformation of single cells into malignant tumors among genetic changes copy number alterations cnas are recurrent chromosomal events that increase or decrease the dosage of specific regions of dna can affect up to 30 of a cancer cell genome and are associated with poor clinical outcomes despite their pervasiveness the functional effects of specific cnas on cancer phenotypes remain largely unknown as current approaches cannot faithfully recapitulate the unique properties of these chromosomal alterations indeed cnas can uniquely affect the expression of hundreds of linked genes and change dna topology which in turn can promote intratumor heterogeneity as illustrated by random segregation of oncogenes in extra chromosomal dna ecdna in order to study the functional role of cnas in cancer this proposal employs machete a novel genome engineering toolkit that enables the generation of megabasesized deletions gains and oncogene amplification in ecdna using pancreatic ductal adenocarcinoma pdac as a disease model we will engineer the major cnas in this lethal tumor to dissect their role in immune evasion metastasis and response to therapy additionally through sequential engineering we will study whether the order of cna acquisition leads to divergent or convergent phenotypes a highly relevant yet unexplored aspect of cancer biology overall by combining the machete genome engineering platform with in vivo cancer models and molecular approaches this proposal will begin to systematically dissect the function of recurrent cnas in pdac with direct implications for therapy importantly the methods and conceptual framework of this proposal are broadly applicable to other cancers and diseases characterized by similar chromosomal alterations where understanding their underlying biology may lead to a new class of cnabased clinical targets
sciencebased brain training at the comfort of your home medically certified

brainhero provides the first medically certified homebased eeg neurofeedback product with personalized therapy for children with asd and adhd it integrates portable low productioncost hardware with its software providing mobile training and advanced features for therapists the set offers simplicity and readiness to use reducing the setup time from 15 to 2 minutes in addition brainhero reduces 10x the cost of the eeg hardware and 60 of the cost of therapy enabling scaling up to many patientswith home therapy our users gain convenience eliminate travel and other logistic problems enable adaptation of individual scheduling and benefit from the comforting and known environment furthermore personalization of the training software according to a patients individual brain profile optimizes training towards neurotypical levelsbrainhero increases 10x adequate training time compared with clinical 1to1 sessions once a week and drastically reduces overhead for parents
personalized drug response implementation and evaluation in ckd

chronic kidney disease ckd is one of the major causes of death in high income countries and its prevalence is growing rapidly new therapies for the treatment of ckd have shown clear efficacy at a population level yet individual patients respond differently with many patients showing suboptimal efficacy this indicates that a one size fits all approach is no longer sustainable currently there are no validated pharmacodynamic biomarkers in ckd that aid in guiding optimal therapy for individual patients furthermore there remains a large gap between biomarker research and actual implementation of biomarker based care in daily clinical practice thus there is an urgent need to validate and translate biomarkers as tools for daily clinical practice primeckd has a unique advantage to address this challenge as it builds on recently discovered pharmacodynamic biomarkers for ckd treatment and has access to a vast amount of clinical data biosamples prime ckd will 1provide a breakthrough in the pharmacotherapy of ckd with the validation and implementation of pharmacodynamic biomarkers which will advance personalized medicine 2scientifically validate innovative clinical trial elements pipelines and qualification procedures that can be used by researchers diagnostics industries and regulatory authorities 3establish a stakeholder network to truly engage patients clinicians and other stakeholders in implementation of personalized medicines4develop a roadmap for biomarker use in daily clinical practice for the optimal treatment of ckd these results will enable clinicians to match patients with ckd with the most effective available drug within the shortest possible timeframe leading to less disease burden and progression of disease enhanced quality of life and increased costefficiency primeckd results will thus unlock the potential of biomarkers in healthcare and close the gap between biomarker research and clinical use in daily practice
decoding communication between mobile genetic elements

communication between organisms is one of the most sophisticated forms of social interactions it has been recently discovered that bacterial viruses phages show multiple social attributes including the ability to communicate extracellularly with their progenies through a peptidebased system called arbitrium this system is utilized by phages to guide lifecycle decisions such as the transitions between their quiescence and virulence states it has subsequently become clear that this system is not exclusive to phages but is also present in other mobile genetic elements mges and that its underlying design and function has diversified considerably despite the wideranging impact of these discoveries the molecular basis of these new systems of communication and their function in different mges remain to be deciphered more importantly although it has been proposed that phages only communicate with their progeny our preliminary results indicate that the arbitrium system can be used by phages and other elements to communicate with unrelated mges sometimes present in different bacterial species however the prevalence and ecological role of this unprecedented intermge communication is unclear in the talkingphages project well explore all these questions and establish the molecular basis used by arbitrium systems to shape mge diversity interactions amongst mges and bacterial ecology and evolution our team combines expertise in mges and communication systems using tools from genetics penads biochemistry marina and ecoevolutionary dynamics eldar by exposing the multilayered network of communications between mges which is amenable for exploration on multiple levels of resolution this project would set a milestone in understanding the complex ecoevolutionary dynamics of mges and the relevance of their sociality with potential impact on our understanding of virulence and resistance in clinically and agriculturally important bacterial species
developing tree ring genomics to understand the genetic basis of and predict forest response to climate change

economically important and ecologically dominant conifers are succumbing to drought disease earlybudding and other challenges globally because mature trees are no longer adapted to their current environment under climate change if we can understand how individual trees respond to different environments we can match seed sources to an appropriate environment existing approaches for understanding adaptive responses to variable environment are effective but agronomic approaches are limited by both long generation times and the genetic diversity they can evaluate and significant variants discovered in environmental gwas in natural populations are often associated both with adaptation but also demographic structure confounding inference we propose a system for quickly estimating adaptive responses for any forest tree focusing on annual growth measurements measured from increment core samples provides replication of a given genotype across hundreds of experienced yearenvironments this allows us to partition growth variation into generalizable environmental responses for years with historical weather or biotic information using quantitative genomic and ecological approaches to control for correlated responses we focus on the economically and ecologically important conifer norway spruce picea abies to 1 develop models and infrastructure to understand the fraction of annual growth that can be attributed to genotype environment and genotypebyenvironment interactions gxe 2 map the genetic basis of adaptive response using estimates for gxe as a response in genomewide association studies gwas and 3 predict genetic responses to novel environments this approach will enable estimation of the genetic basis of adaptive responses in any population providing the means to evaluate a trees performance in any modelled environment as environments shift under climate change this will provide a powerful tool to select parents for healthy resilient forests
noninvasive detection of interictal epileptiform discharges ieds in the mesial temporal lobe mtl during sleep

interictal epileptic discharges ieds are pathological brain activities involving sharp spikes in electrical field potentials that occur preferentially during sleep in epilepsy ieds occur between seizures and often in deep brain regions such as the medial temporal lobe mtlieds during sleep disrupt memory and are associated with cognitive impairments importantly mtl ieds occur not only in epilepsy but also in multiple neuropsychiatric conditions including alzheimers disease ad autism adhd and following traumatic brain injury tbi a major unmet need is to automatically detect sleep ieds noninvasively when they occur in deep regions such as the mtl a task that was believed to be nearly impossible until now we recently developed a novel machine learningbased tool to reliably detect a subset of mtl ieds noninvasively with high precision for the first time ieds originating in the mtl can be detected even when goldstandard visual inspection by clinical neurologists is impossible we will first conduct research to optimize and validate ied detection in epilepsy patients and in mild cognitive impairment mci and ad patients we will then work to commercialize the tool so that it can be widely used to improve diagnosis prognosis drug titration and riskstratification not only in epilepsy and dementia but in diverse neurological conditions including tbi adhd autism and psychiatric disorders together with the technology transfer office of tau and with business partners already on board we will work to consolidate and extend the systems patent family and bring our detection tool to the market
fishing architecture the ecological continuum between buildings and fish species

to what extent can fish produce architecture this project sets out to trace a socioecological history of north atlantic architecture in relation to fisheries elucidating the relationships between marine environments and terrestrial landscapes and assessing the ecological impact of fishing constructions and the natural resources they depend upon fishing architecture covers a broad spectrum in terms of both geography and time a choice that was made to avoid deterministic analysis and engage with transnational phenomena thus the focus is on the north atlanticits shores housing diverse architectural cultures and its waters home to a wealth of fish speciesand follows a time frame that runs from the industrialization of fisheries in the early 19th century to the full globalization of the industry at the end of the 20th the extant scholarship on marine ecology fisheries and fishing communities includes extensive research on fish populations navigation systems technology bioeconomics architecture and cultural practices yet comprehensive interdisciplinary analysis of the field is hindered by its own specialization facing the impending challenges of the environmental predicament this project will use the material history of architecture as a powerful tool for advancing interdisciplinary research and along with it our understanding of the ecological impacts of human activity the assessment will be organized along five analytical axes 1 marine ecosystems 2 fishing technology 3 food processing 4 politics and 5 consumption habits effectively avoiding the conventional architectural approach to understanding the built environment this strategy allows us to identify critical knowledge gaps to be worked on and most significantly fosters a fresh perspective on construction in which fishing landscapes and buildings are understood as material traces of dynamic socioecological relationships and as part of the continuum between land and sea