Dragon09/odtu_chatbot huggingface dataset:
ecoshipyard

ecoshipyard is a research and innovation project aimed at promoting sustainable shipbuilding practices and material circularity in the european union the project is focused on developing solutions to reduce the environmental impact of shipyards increase energy efficiency and optimize operations and also measure and reduce the nonoperational impacts the project team consists of shipyards research organizations and technology providers from different eu member statesecoshipyard will explore innovative ways to manage materials circularity by developing and implementing an eumaterial passport for ships this passport will track the origin and use of materials in shipbuilding maintenance repair and disassembly providing valuable information for the circular management of materials the project will also examine technologies and processes to reduce the environmental impact and improve energy efficiency in shipbuilding and operation these include the use of renewable energy sources electrification of ports and optimization of logistics and operations ecoshipyard will also develop digital tools to support sustainable shipbuilding practices these tools will enable shipyards to monitor and manage their environmental impact assess their carbon footprint and identify opportunities for improvementthe project aims to contribute to the eus environmental and climate goals by effective monitoring of shipyard environmental performance reduce emissions from processes and promote a circular economy in the shipbuilding sector the outcomes of the project will provide valuable insights and best practices for sustainable shipbuilding benefitting both the industry and the environment
the fleet of autonomous robots and fleet management software

advoard robotics produces fully autonomous mobile robots that are aware of each others location and route information and develops software to prevent inefficient picking and labor losses in logistics and ecommerce warehouses these robots can be monitored through an advanced web interface remote accident support and data analysis can be done at the same time data can be exchanged with the warehouse management system this solution includes mapping positioning path planning autonomous driving capability of each robot and sharing this information robots moving in fleets work with maximum efficiency at minimum route length thanks to algorithms based on artificial intelligencethe technology we have developed includes mapping positioning path planning autonomous driving capability of each robot and sharing this information robots that move in fleets work with maximum efficiency at minimum route length thanks to algorithms based on artificial intelligence the most important technologies used are slam simultaneous positioning and mapping and fms fleet management system the slam process uses a complex set of calculations algorithms and sensor inputs to navigate a previously unknown environment or to revise the map of a previously known environment and find a location fleet management system fms is applied to manage and control more than one robot working within the units fms provides complete centralized and decentralized management of the robot fleet allowing users to manage different mobile robotic systems from a variety of devices via standard communication protocols in fms robots share route and location information with each other in the light of this information our algorithms determine the routes in which the robots will perform their tasks without colliding according to our traffic rule sets
lightdriven molecular motors to trigger transmembrane transport of anions

anion transport through membranes mediated by transport proteins is one of the most important processes in living cells recently a number of synthetic transmembrane anion transporters have been developed however unlike proteins they usually do not display responsive behaviour making their function unspecific there are only a few methods known for controlling the transport function of these receptors by physiochemical stimuli with using light being one of the most wellknown these stimuliresponsive receptors however only alternate between distinct on and off states while biomolecular systems are able to use the motion of motor proteins to regulate the passage of ions two first studies have shown that rotating molecular motors can enhance cation transport through membranespanning channels possibly by influencing conformational dynamics however there have been no detailed studies that take advantage of subtle changes in membrane characteristics it would be very promising to enhance and regulate anion transport across the membrane by integrating molecular machinelike entities into lipid bilayers and synthetic transport systems mototrans is a multidisciplinary project that aims to develop transmembrane anion transport systems containing lightdriven molecular motors the outofequilibrium rotational dynamics of lightdriven molecular motors could influence either membrane carrier or channel properties resulting in enhanced transport activity which will be investigated in work packages 13 respectively the project will have three major impacts an innovative approach with profound implications in molecular machines and transmembrane anion transport
controlled transport of water and ions in nanoconfinement

a new technology is emerging based on controlled transport of matter through channels with dimensions from ngströms to nanometres on these scales the macroscopic description of transport phenomena breaks down and it is necessary to integrate experiments with fully atomistic model calculations and control nonequilibrium dynamics recent exciting developments in experimental and theoretical methods mean that we arefinally at a stage where exploration of key processes is viable for this focus it is essential to train a new generation of earlystage researchers in diverse multidisciplinary and intersectorial skills required this in a few words is the aim of fluxionic network which spans four european countries and brings together europes and worlds leading scientists and entrepreneurs precisely because the topic of fluxionic bridges physics chemistry and materials science and necessitates close collaboration with emerging nanoscale industries our major objective is to offer integrated supradisciplinary training and a strong program of secondments with seamless crosssectoral interactions the dn program provides an ideal framework for creating such collaborative researchtraining platform the impact of fluxionic will be broad we will train young researchers with unique and diverse profiles who might become future leaders in the rapidly growing fields of nanoscience and nanotechnology our research willimpact core challenges of modern society clean water disease treatment sustainable energy productionstorageusage investing in training the new generation of researchers in this emerging field of science and technology is determinant for europes future position as the worldleading power promoting sustainable development
ai enabled artistic solutions for sustainable food systems

agriculture has been a nursery for practical solutions to global challenges for a long time eu agriculture is the only major system in the world that reduced greenhouse gas chc emissions by 20 since 1990 nonetheless even though the eus transition to sustainable food systems has started in many areas food systems remain one of the key drivers of climate change and environmental degradation and there is an urgent need to transition to sustainable food systems to realize this ambition actors of the food chain must play their part in achieving sustainability within their food chains to obtain a new quality of sustainable innovation and transform we need another approach including a more diverse and multidisciplinary perspective that enables barriers between science technology industry and the arts to be removed and enabling synergies along the value chain hungry ecocities takes inspiration from the 2008 book by carolyn steel where a core question of civilization social phycological and sustainability impact is put forward how do we feed a city to answer this question in this project growers and agricultural specialists team up with artists designers and creative thinkers to come up with new ideas for the future food system hereby we start from a european approach centered on human needs and values hungry ecocities puts forward a highlevel alliance between science technology and the arts to effectively explore how digital technologies applications can lead in turn to reduced food waste more sustainable value chains ecofriendly attitudes and a more ethical food consumption hungry ecocities brings together some of the worlds most renowned art studios with leading ai and agricultural experts and a network of over 40 leading european agricultural companies to develop ways of creating a more healthy sustainable and affordable agrifood system for all
the next generation ms spidocs

spidocs dn stems from the need to prepare for emerging viruses enabling a fast response as became evident lately basically better knowledge of the dynamic nature of viral structures is required and fundamental to combat with appropriate treatments in this perspective several technologies were developed for structural biology including a cuttingedge approach combining mass spectrometry ms and xrays for single particle imaging spi in ms spidoc despite these advances a major bottleneck that the scientific community will face in coming years will be the lack of expertise with a broad knowledge from theory instrument development and application relevant to structural biology with msspidocs therefore aims to train the next generation of scientists with such expertise by a dedicated intersectoral training programme spidocs projects are highly interlinked and the proposed training programme aims to provide the doctoral candidates with the basic and advanced knowledge to build a common interdisciplinary language to work in teams and to acquire deep knowledge by a combination of lectures and practical sessions an important aspect will be given to data management and the establishment of currently lacking standards for native ms metadatathe research training is complemented by transferrable skills courses setting the basis for progressing through the doctoral studies as well as for future career progression within these modules training on equal opportunities and unconscious bias are included shaping the future generation towards creating fair workplaces special attention will be paid to greenpractice measures from the everyday practice in laboratories and offices up to the institutional level by including developments from computational theory to instrumentation the spidocs beneficiaries and associated partners will closely work together to advance cuttingedge technologies and apply them towards fast response
human skeletal muscle platform for disease modelling and highthroughput drug screening

neuromuscular disorders nmds are a collection of pathologies that affect the skeletal muscle skm function and lead to reduced mobility breathing issues and death most nmds are incurable and existing therapies are generally ineffective the major contributor for the lack of nmd therapies is the absence of human nmd research models applicable for the screening and validation of therapeutic candidates our goal for this project is to develop an in vitro platform containing highly biomimetic and functional skm analogues where nmds can be modelled with the aim of testing drug candidates in a reliable highthroughput ht and quick manner the platform will consist of 96 individual 3d tissue units generated from the myogenic differentiation of human induced pluripotent stem cells hipscs to induce biomimetic and mature tissue formation the platform will combine a unique topographical design with a lightstimulation system for optogenetic control of skm contraction using imagebased assays and computational algorithms we will be able to automatically extract and quantify the skm phenotypical eg intracellular structure and functional eg contraction speedforce parameters to show nmd modelling ability within the platform we will knockout bin1 a gene whose mutated form is involved in the onset of centronuclear myopathy cnm a fatal and incurable nmd the validity of the nmd model as a drug discovery platform will be demonstrated by testing compounds with known therapeutic activity this proof of concept project will lay the ground work for a spinoff company devoted to ht drug screening for nmdsthe successful development of this platform will provide an invaluable tool for pharmaceutical research allowing accurate convenient and costeffective identification of novel drugs and therapeutic targets for nmds and ultimately contributing to the acceleration of novel therapies for nmd patients
comprehensive platform for the functional characterization of cancer epigenetics and diagnosis

epigenetic regulation of gene expression the mechanism responsible for establishing and maintaining cellular identities during development is frequently deregulated in cancer our working hypothesis is that this deregulation confers upon cells phenotypic plasticity resulting in intratumor heterogeneity which is key to tumor development metastasis and drug resistance in epicancer we seek to provide the technological means to address fundamental issues concerning epigenetics in cancer namely we intend to develop apply and validate singlecell and singlemolecule epigenetic analysis methods that can parse the function of this network and its heterogeneity in human cancer and utilize it for cancer diagnosis we will build a rich arsenal of tools to profile the combinatorial epigenetic network in primary tumors and blood taken from cancer patients at multiple scales of resolution aims 1 2 we will apply these systems to elucidate the function and connectivity between epigenetic modifications in breast cancer and lymphoma and link epigenetic heterogeneity to tumor biology and clinical outcome aim 3 we will also establish revolutionary systems for cancer diagnostics and monitoring leveraging the unique advantages of our singlemolecule tools for multimodal analysis of epigenetic protein biomarkers and micrornas originating from both the tumor and its microenvironment in patients blood aims 1 3the epigenetic technologies we intend to provide the scientific community are set to profoundly impact our understanding of the epigenetic determinants of cancer as well as our ability to detect cancer at early stage from a routine blood test and identify early disease recurrence the analysis of a large cohort of tumor and blood samples from the same patients will generate novel datasets that are expected to reveal cancerspecific and patientspecific epigenetic modules and shed light on the contribution of epigenetic plasticity to tumor biology
womens health tech scaleup in europe

there is a gender gap in healthcare and womens health suffers from lack of prioritization preforma as is a deep tech company wanting to close this gap and improve womens health our short term objective is to introduce our product in europe develop our platform further and position ourselves for scaling up with europe as our home market preforma as has a female founder and a majority of women in managementpreforma as is founded by maria rder a researcher and gynecologist who over a number of years has systematized best practices and developed tools to improve gynecological examination diagnosis and treatment in interaction with more than 40 000 patients and healthcare personnel weve developed a dynamic medical history collector and started conceptualizing a deep tech platform for a wider range of servicesour main challenges are limited international network market acceptance international commercialization experience people management business plan and market entry strategy and investor relationswe propose a work plan with a duration of 12 months with two work packages 1 a business work package focusing on product market technology and funding and a 2 people package focusing on talent and network the work packages will go in parallel and will have common administrative processes the main participants from our company are maria rder founder and ceo and madeleine andresen ctoeven if weve come a long way already we are certain that the women techeu programme will enrich our project to include activities that gives us a better insight in the european market a better understanding of legal and customer requirements and also of possible competitors and partners we also need help to improve our internal competences and enhance our network
new medical cybersecurity assessment and design solutions

the european health care system is moving toward personalised distributed and homebased services this is made possible via new and improved connected medical devices mds and in vitro diagnostic devices connected to the internet together cmds and will benefit health care providers in terms of reduced cost fewer hospital beds and improved service patients will see improved quality of life in terms of reduced travel time and reduced stress via treatment at home or where they want it however for these benefits to be fully realised the cybersecurity of cmds needs to be ensurednemecys will benefit practitioners such as cybersecurity communities md manufacturers cmd scenario system integrators and cmd scenario operators eg health care providers with downstream benefits to patients and the wider public through more costeffective and efficient care enabled via effective and streamlined cybersecuritynemecys helps practitioners to 1 comply with md regulations 2 to be able to apply proportionate md cybersecurity too little security risks exposure too much is costly and can obstruct clinical care and 3 build in cybersecurity by design for both mds and the connected scenarios they operate in this is achieved by 1 providing recommendations for best practice and guidelines for md cybersecurity by design along with compliance assurance tooling 2 providing a riskbenefit scheme to address cybersecurity risk balanced with clinical benefit and 3 providing a set of specific tools to address md cybersecurity by design and their deployment in connected scenariosthe nemecys team has cybersecurity risk experts two hospitals who are already implementing iot and remote carebased scenarios three medical device manufacturers major computer science research players and experienced systems integrators this team is ideally placed to ensure that nemecys can enable practitioners to apply the right security at the right place at low cost
characterization of spinal learning in a repetitive yet skilled locomotor task

animals adjust movement throughout their life to adapt to a changing environment and to learn new motor skills the underlying mechanisms have been studied for decades almost exclusively as a function of the brain interestingly however the spinal cord adapts and learns motor sequences without the brain using only spinal sensory feedback therefore the spinal cord must contain adequate neuronal circuitry for motor learning this project aims to characterize brainindependent mechanisms of learning that take place within the spinal cord with a complete thoracic transection i will functionally isolate the lumbar spinal cord from the brain and enable hindlimb locomotion on a motorized treadmill with pharmacological stimulation using a skilled yet repetitive locomotor paradigm i will identify celltypes indispensable for obstacle learning through circuit manipulation our preliminary data indicate that mice learn to avoid obstacles and improve their performance over weeks we will test the integrity of this performance upon specific and acute inhibition of a selected neuronal population during the behavioral task furthermore using invivo awake eletrophysiological recordings i will characterize circuit dynamics that underlie motor learning capacity attributed to the spinal cord while mice perform the obstacle task this project maximizes the synergies of the host labs expertise ie kinematic analysis circuit dissection and the use of highdensity neuropixel probes and my expertise in electrophysiological recordings in mouse spinal cord in addition to implementing an innovative system of multichannel recordings of spinal circuits in behaving mice knowledge gained from this project will enable linking celltype specific activity profiles in the spinal cord to a motor learning behaviour for the first time this link is an essential yet currently missing piece to understand how the spinal cord contributes to the acquisition of a new motor repertoire
digital modelling and simulation for design processing and manufacturing of advanced materials

european materials industry is considered a key enabler for industrial development and the eu has a historically strategic position in this sector however there is a low uptake in european materials industry for digital technologies hereby it is crucial to provide all stakeholders of the eu with advanced digital technologies to evolve towards an agile european materials industry with intelligent enterprises that maximise and integrate the utility of digital materials sciences knowledgedimat will develop open digital tools with a set of advanced technologies for offering european smes and midcaps an affordable in terms of cost implementation and usability full modelling simulation and optimisation system in each stage of the material value chain design processing and manufacturing for improving quality sustainability effectiveness and competitiveness of materialsdimat will deploy 3 integrated suites 1 dimat data and assessment suite digital technologies for storing sharing representing and assessing materials data 2 dimat dimat modelling and design suite digital technologies for material design in terms of their internal structure properties and performance in order to predict the material behaviour before manufacturing 3 dimat simulation and optimisation suite digital technologies for creating efficient materials manufacturing simulation processes and determining the behaviour of the material mechanical characterization models to be used in the ai training and predictionthe dimat suites will be demonstrated in 4 pilots of european designers and producers of different materials textile composite glass and graphite