Dragon09/odtu_chatbot huggingface dataset:
support to the vicepresidents of the erc scientific council 2023

the european research council erc provides a competitive platform for investigatordriven frontier research at the european level it is led by a scientific council scc consisting of 21 eminent scientists and their president and it is this council that independently establishes and oversees the ercs scientific management and the implementation of its work programme this project aims to support the erc vicepresidents who act on an honorary basis in the efficient and timely achievement of the sccs goals in 2023 this project will provide local administrative and advisory support to the three erc vicepresidents the staff supported by thisproject will provide analysis of the output of the erc and the scc to the vicepresidents preparatory work for the meetings of the scc support with scientific outreach and representation as well as maintaining a clear and efficient channel of communication between the vicepresidents and the ercs executive agency a key duty of the vicepresidents is maintaining the integrity of the ercs evaluation panels and the staff supported by this grant will facilitate this by providing detail information and analysis of potentialpanel members to the vicepresidents to allow them to take informed decisions on recruitment the staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process the impact of the project will be to ensure the efficient and wellmanaged operation of the scc this support is required as the duties of the vicepresidents demand a considerable portion of their time by allowing the vicepresidents to effectively and efficiently perform their duties this project willcontribute significantly to the continued implementation of the erc under horizon europe
artificial intelligence for the simulation of severe accidents

the assas project aims at developing a proofofconcept sa severe accident simulator based on astec accident source term evaluation codethe prototype basicprinciple simulator will model a simplified generic westerntype pressurized light water reactor pwr it will have a graphical user interface to control the simulation and visualize the results it will run in realtime and even much faster for some phases of the accident the prototype will be able to show the main phenomena occurring during a sa including invessel and exvessel phases it is meant to train students nuclear energy professionals and nonspecialistsin addition to its direct use the prototype will demonstrate the feasibility of developing different types of fastrunning sa simulators while keeping the accuracy of the underlying physical models thus different computational solutions will be explored in parallel code optimisation and parallelisation will be implemented beside these reliable techniques different machinelearning methods will be tested to develop fast surrogate models this alternate path is riskier but it could drastically enhance the performances of the code a comprehensive review of astecs structure and available algorithms will be performed to define the most relevant modelling strategies which may include the replacement of specific calculations steps entire modules of astec or more global surrogate models solutions will be explored to extend the models developed for the pwr simulator to other reactor types and sa codes the training database of sa sequences used for machinelearning will be made openly availabledeveloping an enhanced version of astec and interfacing it with a commercial simulation environment will make it possible for the industry to develop engineering and fullscale simulators in the future these can be used to design sa management guidelines to develop new safety systems and to train operators to use them
enabling laser powder bed fusion for large scale production of multimaterial components

while laser powder bed fusion lpbf inherently allows the production of complex geometries it isnt yet introduced to mass markets due to prohibitive cycle times and uncompetitive product precision and quality a hybrid production where complex components using lpbfs flexibility are built on top of conventionally manufactured substrates at nearnetshape geometry can speed up the production process dramatically especially if applied to small component volumes globalam aims to advance and combine existing stateoftheart approaches namely beam shaping beam splitting insitu geometry correction and process monitoring control in an advanced machine concept that allows fixation of multiple substrates and laser beam positioning to produce components on a large scale as a demonstrator a cooling device for power electronics is chosen because it combines typical challenges in a prototypic way complex metal geometries made from challenging materials such as copper are built on a ceramicbased substrate with a required precision in the low micrometer scale if the technological barriers towards the demonstrator can be solved globalam will introduce but not limit lpbf to the multibillion euro mass market of power electronics with highly attractive technological economical and environmental benefits to make this project successful experts from renowned universities and worldleading companies in the disciplines of production technology laser systems process developmentmonitoringcontrol and modeling as well as powder production for advanced multimaterial powders join their efforts in close multinational cooperation
artificial intelligence for in vitro fertilisation

at mim solutions we are using artificial intelligence and machine learning to address the worldwide fertility disorder occurring in an increasing number of countriesspecifically we are developing two solutions embryoaid httpswwwmimsolutionsaiembryoaid and folliscan httpswwwmimsolutionsaifolliscan that utilize ai to help couples struggling with infertility to conceivewe have been developing those technologies for 2 years now and we have developed our mvp that are ready to be certified and commercialized however this is an enormous organisational financial and startegic challenge for mim solutions short about the company the company is the first spinoff of the faculty of mathematics informatics and mechanics of the university of warsaw we are committed to combining rigorous scientific research with solutions to realworld problems we provide organizations with the most efficient and at the same time the safest ml technology remaining at the forefront of scientific research in this field founderled and with the majority of phds mim solutions has one of the most experienced teams of ai and ml experts in polandawards innovator of the year award awarded by the university of warsaw 2022 central european bioforum award 2022 in the biodigital category
evidence driven indoor air quality improvement

indoor air pollution an emerging threat recognized by european society is claiming millions of lives annually in the heat of current covid19 pandemic elevated exposure to indoor air pollutants due to increased time spent indoors further faces a significant increase in negative effect on both physical and mental health and wellbeing not only in europe but also worldwide when it comes to indoor air quality itself serious knowledge gaps remain in understanding complex nature of indooroutdoor pollution relationships pollution sources and exposure pathways health effects of emerging pollutants ventilation of indoor spaces on wide spatial and long temporal scales this is mainly because air quality monitoring in european union eu is primarily focused on outdoor air quality which paradoxically is a result of regulatory target compliances which is lacking for indoor environments to increase the resilience of eu for emerging threats of indoor air pollution and to promote living and working in healthy environments project ediaqi aims at conducting characterization of sources and routes of exposure and dispersion of chemical biological and emerging indoor air pollution in multiple cities in eu quantification of the main properties of pollutants and processes that governs its fate in indoor environments will be investigated on two levels a thestateoftheart smallscale highintensity scientific focus measurement campaigns and b longterm largescale monitoring of target indoor air pollutants the chosen project strategy for developing characterization and deployment of costeffectiveuserfriendly monitoring solutions together with thestateoftheart scientific instrumentation will allow to create new knowledge on sources routes of exposure and body burdens of indoor multipollutant
dissecting the neutrophilcancer cell interactome in the metastatic bone niche

bone is one of the most common organs for solid tumour metastasis 75 of patients with latestage breast cancer develop recurrence in bone current treatments are palliative leaving this condition incurable with an unmet need to identify new therapies inflammation is an important player in cancer my pilot data show that depletion of a specific immune cell type neutrophils impairs bone metastasis in vivo suggesting that neutrophils have tumoursupporting functions however the role of neutrophils in the metastatic bone niche remains largely unexplored it is unknown whether they contribute to the seeding or the expansion phase of bone metastasis and if tumour cells regulate neutrophil plasticity therefore skewing the balance towards protumourigenic neutrophil subsets i hypothesise that neutrophils acquire protumourigenic phenotypes when in close proximity to cancer cells and support metastatic progression by regulating the tumour niche by using a liposoluble fluorescent protein expressed by cancer cells neighbouring neutrophils will be characterised neutrophil subsets will be identified by spectral cytometry their transcriptomic signature analysed using rna sequencing and their protumourigenic role functionally assessed in vitro and in vivo by employing a combination of maldimsi and multiplex antibodybased imaging neutrophilcancer cell interactome will be established in order to identify candidate molecular mechanisms regulating neutrophil protumourigenic functions by using in vivo models of neutrophil extracellular traps nets blockade neutropenia neutrophilia and enhanced neutrophil retention in the bone marrow neutrophil candidate mechanisms shaping the metastatic niche will be determined dissecting the molecular mechanisms regulating protumourigenic neutrophil subsets is fundamental to identify novel means of inhibiting bone metastasis without affecting neutrophil critical functions in inflammation
sea straits and biogeography the role of the strait of gibraltar in shaping europeanafrican heathland plant biodiversity

the strait of gibraltar is a unique hotspot of plant biodiversity within the mediterranean basin considered as both a glacial refugium and a relatively permeable biogeographical barrier for plant biodiversity due to its geological edaphic and climatic singularities at both sides of this strait two heathland habitats of high conservation value and shared edaphic features acid infertile and sandy soils deserve attention mediterranean dry heat herriza and temperate atlantic wet heath whose floras present a peculiar population genetic structure pointing to ecoevolutionary processes such as successful colonisations across the strait of gibraltar and isolation by ecogeographic barriers as main drivers in shaping heathland plant biodiversity nevertheless the knowledge about this is still limited in the present project a multidisciplinary approach integrating genomics phylogeography phylogenomics demographic inference and community ecology is proposed to contribute to a proper understanding of the role of the strait of gibraltar as biogeographical bridgebarrier for both heathland habitats although particularly relevant for the forgotten but threatened wet heath flora likewise the proposed project will enable to detect key biodiversity areas probable glacial refugia and the potential response of heathland plant biodiversity to climate change essential information for its effective management and conservation
she sense an accurate and noninvasive test that enables simpler earlier and more costeffective diagnosis of patients with endometriosis

endometriosis is a chronic inflammatory disease defined as the presence of endometriumlike tissue outside the uterus establishment and growth of such endometriotic tissue is estrogendependent thus it is mostly found in women of reproductive age it is estimated that currently at least 190 million women and adolescent girls worldwide are affected by the disease during reproductive age although some women may suffer beyond menopauseshe sense is an accurate and noninvasive test that enables simpler earlier and more costeffective diagnosis of patients with endometriosisproject scope experimental proof of principle for the novel digital biomarker has been demonstrated using early generation prototypes for research purposes in a preclinical model and exploratory human volunteer study sision medical seeks to mature this technology and validate its use as a clinically acceptable diagnostic test therefore the scope of this project will focus on the advancement of the she sense test to investor readiness byfurther refinement of the signal processing to optimise the digital biomarker performancevalidation of the biomarker in a clinical settingdevelopment of a sustainable business case and business model towards commercialisationthe end point of the project is the compilation and evaluation of data obtained in a prospective clinical study eic funding will enable sision medical to enhance the technology efficacy and validation in a clinical setting this will pave the path for larger studies which will demonstrate clinically acceptable sensitivity and specificity of the she sense diagnostic test
a next generation high level sensing system to enable safe and high level automation of industrial vehicles

the problem with todays autonomous system architectures is that minimal changes in the camera alignment of less than 1 mm can lead to significant misalignments and invalidate measurements of the surrounding environment leading to major safety concerns in autonomous vehicles tripleye has invented the cop circular optical perception to solve this issue the cop is a next generation camera only computer vision system that uses proprietary algorithms named kiev and rubberstereo together with a fisheye camera to triangulate and capture high level 3d spatial components needed for advanced automation specifically cop offers a revolutionary solution for the safe and efficient operation of earthmoving material handling and automated guided vehicles during the proposed eic project tripleye will look to upgrade its software stacks integrate the system into material handlingearth moving machines in a real working environment for iterative testing
holographic nanoscale imaging via femtosecond structured illumination

solutionprocessed organic and hybrid materials have immense promise for lowcost photovoltaic devices their intrinsically heterogeneous morphology directly impacts the photophysical processes that happen over multiple timescales down to femtoseconds and which ultimately define functionality such as carrier diffusion charge separation and recombination currently experimental techniques that can simultaneously study the nanoscale morphology and the ultrafast photophysics are limited ultrafast microscopes are restricted to single point or very small fields of view lacking the large sample area coverage needed to place observations in their proper statistical context moreover they are generally incompatible with superresolution imaging preventing the required nanoscale spatial resolution from being achieved recently i introduced a widefield transient holographic microscope using offaxis holography that has shotnoise limited performance and can image large sample areas importantly this approach is compatible with nonlinear structured illumination a widefield superresolution technique based on combining a spatially structured illumination pattern and a nonlinear sample response with the spatial resolution being only limited by how many nonlinear terms can be acquiredin holofast my team and i will combine the new ultrafast holographic microscope with nonlinear structured illumination to bring unprecedented photophysical knowledge of organic photovoltaic materials with temporal resolution down to 10 femtoseconds spatial resolution down to 50 nm while simultaneously imaging 100 micron areas correlating morphology with excited state dynamics this will enable us to finally reveal the heterogeneity of charge separation and extraction processes over large sample areas holofast will create a photophysical and morphological database that will be valuable to understand and solve the problems that currently limit device efficiencies and lifetimes
bacteria biofilm as biofactory for tissue regeneration

bioaction aims at developing a new methodology in implant technology based on functionalized biohydrogels that will convert the negative occurrence of biofilmassociated infections the primary cause of implant infections and failure into a positive resource the main goal of bioaction is to transform implantassociated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration exploiting gene sequences loaded on engineered liposomes and phages bound to hydrogel scaffolds bioaction will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues it will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and periimplant infection treatments the proposed approach will be validated in two clinically relevant animal models dental implant and permanent transcutaneous bonebioaction would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care health outcomes and to achieve huge socioeconomic benefits the project isstrongly interdisciplinary in nature involving expertise biomaterials synthetic biology phage and liposome technology medicineas a results this innovative approach will bring the research and knowledge far beyond the current stateoftheart and will lead through the planned validation as proofofconcept of new materials and technique with a broader application in regenerative medicine
thermography ai cornerstone in future preventive healthcare

it is estimated that more than 230m people worldwide suffer from peripheral arterial disease pad and each year more than 22m of them develop critical limb ischemia a lifethreatening condition with 50 combined incidence of amputation andor death in a 3year period timely pad diagnosis is the most important factor to avoid complications by treatment procedures revascularization and proper disease management daily walks change of dietary habits etc unfortunately half of the padsuffering population is asymptomatic and therefore lately diagnosed recent technology advancements in thermography portable highresolution and precise hardware and artificial intelligence scalable infrastructure and highly accurate computer vision analysis can support much needed progress towards continuous and preventive and valuebased healthcarekelvin health develops a clinical decision support system based on thermography ai for noninvasive costefficient populationwide screening and diagnosis initially addressing pathology related to pad blockage or narrowing of limbs blood vessels the system applies a portable thermal imaging camera that captures body thermodynamics and generates a series of thermograms which are then thermally segmented and analyzed temporarily using ai image recognition algorithms the ml model is trained to detect anomalies related to the vascular system using stateoftheart machine learning algorithms such as deep neural networks and in particular convolutional neural networksaicare proposal aims at addressing the challenges we meet to structure clear regulatory pathway for market approval at initial target markets design a clinical validation study and assess the patentability of our method at the same time promoting women entrepreneurship especially in deep tech healthcare where women are highly underrepresented successful project implementation will lead to kelvin healths success in rd capital fundraising
waves for energy in magnetized plasmas

the interplay between energetic particles and magnetohydrodynamics mhd fluctuations plays a paramount role in a modern society with growing energy demands and active interaction with the space weather the prediction of space weather and viability of fusion as a virtually unlimited source of energy rely on a good understanding of fundamental waveparticle interactions although the sources of energetic particles are quite different for space astrophysical and laboratory plasmas the main challenges remain the same 3d multiscale physics and nonlinear waveparticle interactions in the framework of smartwaves a potentially revolutionary plasma regime for future burning fusion plasma devices with tailored mhd activity will be developed novel diagnostic techniques to monitor the temporal evolution of the energetic ion distribution in phasespace will allow the identification of the fundamental waveparticle resonances responsible for the experimental observations combined with the next generation of electron fluctuations diagnostics i will provide a complete physics basis of currently inaccessible wave phenomena this will pave the way towards a highconfinement plasma regime that closes the burning plasma performance and exhaust gap simultaneously maximizing the fusion gain and minimizing the plasmawall interaction advanced 3d nonlinear codes validated in tokamak plasmas will be applied to relevant solar events paving the way to a space weather forecast station i will apply the basic knowledge gained in tokamaks with advanced insitu diagnostics to test and further develop hybrid models and numerical tools shared by the fusion space and astrophysical communities this project will represent a gateway between the space astrophysical and fusion communities opening new horizons for a common ground science
inducing trionic gain in twodimensional semiconductors by local strain and charge manipulation

the ability to manipulate excitonic complexes in 2dmaterials is of fundamental importance for the development of excitonic based optoelectronic devices operating in lowcarrier density lowpower regimes correlating locally variable quantities with emission properties of excitonic complexes on subdiffraction length scale could enable ondemand control of the mutual conversion between excitons and trions in particular control over trion density upon photoexcitation in a functionalized 2dmaterial disclose the possibility to achieve trionic optical gain that is a condition of optical gain sustained by the difference between trion and predoped electron density as a peculiarity trionic optical gain does not require global population inversion common to optical gain mechanisms of conventional semiconductors therefore trion density control could enable optical amplification and lasing at unprecedented low levels of excitation to this end we aim to understand the photoexcitation dependent trion formation process their abundance and stability upon variation of local quantities such as carrier doping defects density and strain fields in 2dmaterials to pursue this goal we will implement a structural spectroscopic correlated approach based on hyperspectral nanoimaging and farfield cryomicroscopy of 2d monolayers transferred on a plasmonic nanopillars array with controlled levels of charge doping and strain demonstration of trionic optical gain in such conditions will provide the necessary requirement for achieving trionic lasing laser feedback will be then realized by engineering the surface lattice resonance of a plasmonic nanopillar cavity to match the trionic peak gain wavelength