Dragon09/odtu_chatbot huggingface dataset:
ion mobility mass spectrometry training network

ion mobilityhigh resolution mass spectrometry imhrms is the nextgeneration analytical platform in research and industry unlocking its full potential across applications as varied as biotherapeutics environment and food safety requires not only pushing back the frontiers of instrumentation fundamental understanding and applications but harmonisation is essential to achieve this current shortcomings in data collection analysis and reporting across instrument types laboratories and research areas need to be scrutinised and overcome the mobilitrain doctoral network will form 13 doctoral candidates dcs who will bring a new fundamental understanding of imhrms provide reference materials and guidelines for standardisation develop stateoftheart methods for the application of imhrms in biopharmaceutical development biological omics studies and nontarget screening of contaminants and lay the foundations for imhrms adoption in industry through an interdisciplinary research programme including an open science approach and training in technical business and transferable skills the mobilitrain dcs will become leading experts in ion mobility with a unique skill set to successfully advance their careers while supporting europes innovation capacity building on existing collaborations and research excellence covering the entire innovation chain of imhrms development and application mobilitrain unites 10 academic institutions 3 leading instrumentation companies 1 regulatory agency 1 pharma industry leader and 5 smes from 8 countries with complementary expertise knowhow and mentoring experience our consortium is ideally suited to unveil the potential of imhrms as a key technology for safer therapeutics better understanding of complex disease progression and improved monitoring of food water and public health safety
common standards for security privacy and cost of the surveillance of public gatherings

local surveillance assemblages can be broken down into three constitutive and interrelated parts technologies used stakeholders involved and the data transfer between them this project uses the notion of the surveillant assemblage proposed by haggerty ericson 2000 and inspired by deleuze guattari 1988 as the starting point to provide a better understanding of how surveillance technologies are governed surveillance practices threaten the privacy of citizens and visitors of public gatherings but they also have a social impact and economic cost the first overarching purpose of the gatherings project consists of three ambitions to improve the efficacy of surveillance in order to render public gatherings safer to increase the fairness and transparency of surveillance by making it more privacyfriendly to boost feasibility of surveillance for involved stakeholder by making it more costeffective both economically and sociallythe second overarching purpose is to identify gaps in terms of awareness among professionals and citizens and bringing about international harmonisation of good practices and common standards with regard to the privacyfriendly socially sensitive costeffective surveillance of safer public gatheringsin order to respond to the call priorities the gatherings project will develop common standards to maximise privacy and data protection in surveillance practices develop an accessible matrix to be used by surveillance professionals local administrations and event organisers to weigh security against privacy economic cost and social impact set up an international network of surveillance professionals administrations experts policy makers and citizens develop an awarenessraising programme for citizens and civil society develop an awarenessraising programme for surveillance professionals formulate policy recommendations search for synergies with other ongoing security research projects
advancing nucleosynthesis predictions with modern supernova simulations

corecollapse supernova ccsn explosions mark the end of the life of stars heavier than 10 times the mass of our sun they play a crucial role for our understanding of the chemical composition of the universe and they are ideal laboratories for effects of neutrino and particle physics current research in astrophysics astronomy and cosmochemistry that requires theoretical ccsn models still however relies predominantly on onedimensional ie spherically symmetric parameterized calculations this project aims at advancing the stateoftheart by calculating the composition of ccsn material based on the most recent firstprinciples 3d simulations and by providing the results to the community in accordance with fair data management principles the researchers background in nuclear and neutrino physics will also allow him to study the implications of uniquely multidimensional asymmetries in the neutrino emission and the consequences of neutrino flavor conversions a quantum effect that changes the particles spectra for nucleosynthesis both of which have never been explored and may lead to observational signatures to achieve the goals a new and innovative framework for nucleosynthesis calculations at the maxplanck institute for astrophysics in garching will be developed based on an opensource reaction network code which the researcher has contributed to and that he will apply to unique cuttingedge models the fellow will obtain indepth knowledge about supernovae and learn stateoftheart techniques from the worldclass team of prof janka and apply them he will broaden the scope of his work complemented by a career development plan training courses and coaching as well as detailed dissemination and public outreach plans to maximize the impact of the projects outcome the completion of the project will allow the fellow to become a mature and independent scientist wellrecognized in his field of research
magnetic resonance at the scale of a cell

the hypercell project merges two groundbreaking technologies to validate a benchtop tool for cell metabolic analysis promising to revolutionize cell research it empowers researchers to explore individual cell metabolic profiles unveiling hidden disease mechanisms understanding organism development and revealing treatment responses this innovation fills a crucial gap in the field as current methods struggle to provide reliable metabolic data at the micro to picolitre scalehypercells standout feature is its noninvasive approach to deliver quantitative metabolic information at the singlecell level without disrupting cell metabolism this unique capability positions annaida and nvision as global leaders in nmr technology offering an unmatched solution in the market the initial application for this technology is embryo analysis addressing infertility a widespread issue affecting one in six couples globallythe project will focus on the optimization integration and validation of nvisions quantumbased platform which enhances nmr spectrometers sensitivity to metabolites via hyperpolarization enabling realtime monitoring of intracellular metabolic activity with annaidas embryospin sensor technology tailored for microscale nmr
developing a surgical infection treatment to reduce amputations healing times and hospital stays for diabetic foot patients

xtremedy medical is a surgical ablation company founded in 2018 to commercialize technology treating deep wound infections including diabetic foot infections dfi our pulsed field ablation pfa system is the first to deliver electrical currents noninvasively to achieve superior clinical outcomes including faster cure of infections reduced surgeries and shorter hospital staysthe problemdeep tissue and bone infections are life threatening infections that affect a millions of europeans every year immunosuppressed patients are particularly vulnerable with diabetic foot ulcer infections a leading cause of amputations in europe these patients are incredibly difficult to treat requiring multiple surgeries lengthy hospital stays and longterm antibiotics in 20 of patients an amputation is required to control the infection surgical intervention to remove infected tissue is the cornerstone of treatment but surgeons must balance removing infected material whilst preserving healthy tissue required for healing treatment landscapecurrent treatment modalities either only treat the surface of the wound or use mechanical forces to treat below the surface surface treatments fail as they leave infection below the wound bed untreated mechanical devices can cause more severe infections by damaging the integrity of the wound bed and propelling the infection deeper as a result these treatments are often ineffective with 50 of patients requiring additional surgeriesxtremedy solutionxtremedy medical have developed a surgical device that delivers electrical signals through the wound this device treats both the surface and below to zap any residual infection the technology is nonthermal and preserves the integrity of the wound during treatment helping reduce the time required for healing patients benefit from reduced surgeries shortened hospital stays and antibiotic durations following surgery
sustainably and digitally driven hierarchical laser texturing for complex surfaces

syntecs brings together a consortium of industry leaders and academic and research organisations that are at the forefront of laserbased processing syntecs is designed to tackle the multiple challenges experienced with current chemical and mechanical surface treatments the overall aim of syntecs is to develop and demonstrate a digital and green laser texturing approach to generating complex multifunctional surfaces a machine platform will be developed trl6 that enables interchangeable direct laser writing dlw direct laser interference patterning dlip and laser induced periodic surface structuring lipss with a multiaxis motion stage for processing complex geometries and an inline monitoring and control system the combined system will streamline the generation of hierarchical surface textures ie textures which combine at least two significantly different sized features the surface multifunctionality enabled by these hierarchical textures will be demonstrated in three industrial case studies an injection moulding tool a hip implant system and a complex shaped vapour chamber surface textures and texturing processes for these demonstrators will be designed using a design for surface engineering software module which will incorporate lca guidance combined with predictive performance modelling to enable sustainablebydesign decision making syntecs will demonstrate that hierarchical laser surface texturing provides a highly efficient and flexible route to replacing multiple typically chemical and mechanical energy and resources intensive surface treatments steps with a single digitally controlled chemical and wastefree process
probing gauge symmetries and gaugematter interactions using tensor networks

we are in the midst of the second quantum revolution highly entangled quantum matter is being discovered engineered controlled and probed across a wide range of scales and conditions quantum platforms are being used to emulate other quantum systems the ability to simulate the quantum world on classical computers has been instrumental in guiding validating and diagnosing these exciting developments as the quantum world is probed beyond regimes of weak coupling and nearequilibrium novel computational methods are required that can faithfully parameterise the peculiar entanglement patterns of physical quantum states in a scalable manner the central goal of gamaten is the design and application of tensor network methods for studying quantum lattice systems with gauge symmetries the universal paradigm that governs highenergy particles as well as lowtemperature condensed matter a computational framework will be developed for targeting interacting gauge and matter degrees of freedom in conditions that are beyond the reach of the ubiquitous monte carlo sampling techniques equilibrium properties of phases with high baryonic densities as well as nonequilibrium dynamical effects such as the phenomenon of string breaking or the spontaneous particle production in strong external fields will be investigated at the conceptual level a unique entanglement perspective on the nonperturbative realspace scaling behaviour of gauge theories will be provided furthermore the advancements in this proposal are essential in order for tensor networks to uphold their instrumental role in assisting and benchmarking future quantum simulation proposals and experiments the tensor network algorithms developed in the gamaten project will be optimised for high performance and will maximally exploit symmetries they will be released as a generalpurpose opensource library which offers the potential for a lasting impact far beyond the scope of this proposal
qutest

qutest brings together 13 service providers for a federated network of testbeds and 11 industrial users from the european quantum community the network brings together competences and infrastructures across europe to offer testing and validation services a first goal of this cooperation is to support the creation of a trusted supply chain through the validation of quantum devices chips components and systems by the testbed network as an independent third party a second goal is to discuss and agree on unified sets of parameters to characterize quantum devices methodologies and procedures will be harmonized among the partners of the testbed network in a step towards establishing standards for quantum technologies qutest is aligned along three testbeds quantum computing quantum communication quantum sensing in more detail the quantum computing testbed will measure characterise and validate cryogenic quantum devices cryogenic qubits such as superconducting and semiconducting qubits photonics qubits and ion traps the quantum communication testbed will characterize devices for quantum key distribution qkd and quantum random number generation qrng and provide design and prototyping services to support innovation in the supply chain of quantum communication technologies finally the quantum sensing testbed will benchmark sensing and metrology instruments provided by industry and use a large suite of quantum sensors clocks gravimeters magnetometers imagers to validate industrial use cases aiming at generating new business cases for quantum sensing and metrology devices with additional services of ipr support business coaching and innovation management qutest supports the european quantum industry with a holistic onestopshop to move the full ecosystem forward
satisfiability and group rings

group rings are key objects in many fields of mathematics including algebra topology operator algebras and representation theory fundamental questions about them remain unanswered in particular several conjectures attributed to kaplansky for torsionfree groups and field coefficients the zero divisor conjecture predicts the absence of zero divisors and the idempotent conjecture predicts that 0 and 1 are the only idempotents in the group ring the direct finiteness conjecture says that leftinvertible elements are invertible in group rings of arbitrary groups over fields these conjectures have a history spanning more than 80 years although special cases are known resolving any of the conjectures in full generality seemed intractable until the recent disproof of the closely related unit conjecturethe goal of this project is to construct counterexamples to the zero divisor and direct finiteness conjectures the latter will give the first example of a nonsofic group we also seek to resolve the unit conjecture in characteristic zero key to our approach is the application of modern solvers for boolean satisfiability this paradigm shift which was successful against the unit conjecture shows that these problems are substantially more vulnerable to computational techniques than previously thought constructing our counterexamples will require both developing our understanding of candidate groups and their properties and building a toolkit for the effective application of existing computational machinery the unique product property obstructs the existence of counterexamples to these conjectures and is thus of great interest we will answer fundamental questions about this propertyalthough we focus on the positive characteristic case this project will lay serious groundwork towards the construction of counterexamples in characteristic zero to the zero divisor and idempotent conjectures and thus to the atiyah baumconnes and farrelljones conjectures
in silico trials for cartilage regenerative medicine applications

osteoarthritis oa is a highly prevalent disease affecting 1 in 8 adults worldwide and is projected to increase by 60 in the next two decades due to the intricate interplay between multiple influencing factors such as mechanical loading and inflammation playing out over multiple length scales and tissue compartments currently no diseasemodifying drugs are available on the market the instant carma project aims to harness the power of in silico trials to study oa onset and progression as well as design endogenous drugs and exogenous tissue engineered therapiesa multiscale multifactorial in silico model of the knee joint will be established and validated with dedicated in vitro and in vivo experiments a continuous effort following targeted and untargeted approaches will take place to explore biological hypotheses and implement relevant model extensions in parallel computational upscaling tools will be implemented to prepare the model for execution of in silico trial simulations on virtual patient cohorts the first in silico trial will investigate the effect of modelpredicted drug combinations after experimental confirmation in a rodent model the second trial will seek to optimize tissue engineered constructs for deep osteochondral defect regeneration followed by experimental validation in a small and large animal model to realize its goals instant carma can build on the wellreceived and published work on a wide range of in silico in vitro and in vivo tools developed by the applicant and her team additionally the work will benefit from the applicants extensive network and involvement in regulatory science for in silico medicine this project will further accelerate the uptake of in silico testing strategies in the development of medical therapies in general and osteoarthritis in particular
solarbased membrane reactor for syngas production

sommer will develop and demonstrate a novel carbonneutral pathway for syngas production by integrating solar energy directly into a catalytic membrane reactor for the splitting of h2o and co2 eg captured from high carbon emitting industries or by direct air capture this will allow sommer to overcome the fossilbased energy requirements for the production of syngas and to consume co2 instead of natural gas as feedstock syngas the mixture of h2 and co is a crucial intermediate product in the chemical industry thus sommer will consider the entire valuechain from co2 provision from a cement plant to syngas formation and further processing syngas to valuable and shippable products such as dme or methanol the core of the sommer technology lies in the optimized energy integration of an emerging singlestep co2 and h2o thermochemical conversion process supported by highly selective catalysts and a dualphase composite membrane and a concentrated solarthermal plant to supply the thermal energy demand the main outcomes of sommer involve the experimental demonstration and evaluation of the innovative solarpowered membrane technology and the development of high performance and costeffective membranes as key components thereby bringing the technology to the next level sommer will advance membrane manufacturing via slipcasting as a more mature approach and via additive manufacturing to optimize the effective membrane surface area in the reactor the concept is expected to have the future advantage of prolonged and flexible operation by switching between two operational cases i purely solar approach at 1500 c and ii a biogassupported approach at 900 cin addition the identification of technological ecological and economical potential for a flexible and highly efficient solar syngas production will contribute to the development of a detailed roadmap and provide the basis for the precommercialization through followup rd development activities
foldable reconfigurable jagged devices for enhanced drug absorptionseeding

oral delivery of proteinpeptide drugs is extremely challenging and the majority of research in the field is based on exploring new formulations for instance using permeation enhancers in recent years some research has been done on ingestible devices for internal injections here i propose an entirely new approach based on what we have named selfconfigurable proximity enabling devices speds the idea is that these devices the simplest ones will be rolledup foils will unfold in the gut embed in the mucus layer and align to the intestinal wall it is essential that the sped has close proximity to the intestinal wall and is retained for a while in order to ensure efficient drug delivery the proximity will additionally allow us to study and explore the influence of nanotextures embedded in the sped on the interaction with the intestinal wall as well as micromotorbased delivery the speds will be developed and characterized with the following specific objectives i understanding the sped properties needed to penetrate mucus ii investigating the mechanisms for enhanced retention time iii exploring the sped as a carrier for selfpropelling cargo iv unraveling the overall behaviour of sped and v demonstrating antidiabetic drug formulation delivery with at least 5 systemic uptake and show feasibility of a wider range of applications deliveringseeding eg peptide and proteinsvaccinesprobiotics the work will include simulations of soft materials device design micronano fabrication development and use of techniques for mechanical characterisation of devicetissue interaction bio imaging and in vitro and in vivo studies the major novelty lies in the sped concept providing tissue alignmentcontact and unidirectional drug release further the speds provide a unique platform for studies on micromotors as well as nanotextures interaction with the epithelium