Dragon09/odtu_chatbot huggingface dataset:
immunological mechanisms of respiratory coinfections

despite the concept that infectious diseases are usually caused by a single pathogen in reality we are constantly challenged by multiple pathogens and growing evidence indicates that coinfections are a much more common event than clinically perceived the respiratory tract is the first point of contact with airborne pathogens and the most common site for infections hence human respiratory infections contribute to substantial morbidity and economic losses worldwide resulting in approximately 25 million deaths each year recent findings have shed light on a crucial factor in the severity of respiratory infections the role of coinfections considering the public health importance of respiratory infections and the scarcity of research on the impact of coinfections in the balance of immune defences this project proposes to study the in vitro and in vivo effects of diverse parasitic viral and bacterial coinfections on different types of immune cells in the lungs and comprehensively characterize tissue local microenvironment and hostpathogen interactions additionally we will investigate the immunomodulatory effects of protozoan infections on vaccines and chemotherapy treatments and their impact on the protection against targeted pathogens objectives include elucidate the molecular mechanisms underlying immunological responses in the lungs and the susceptibility to coinfections investigate altered immune responses of vaccines and the changes in the response to coinfection after chemotherapy of the primary infection in the end this study will allow deeper understanding of respiratory coinfections that could pave the way for the development of improved diagnostic and prognostic techniques as well as the potential for proposing supportive treatments and vaccines notwithstanding the development of this project will open up new avenues for future coinfection research and propel the fellow towards establishment as a successful independent researcher
innovative solutions for mediterranean ecosystem remediation via monitoring and decontamination from chemical pollution

the mediterranean sea and its surrounding regions support a diverse variety of essential socioeconomic activities it is one of the highly exploited water ways and the influence of anthropogenic activities on its marine habitats and ecosystems has grown significantly since the industrial revolution because of this the mediterranean sea basin is very vulnerable to chemical contamination and buildup to safeguard the mediterranean sea basin from contaminants for emerging concerns coec imermaid will integrate coordinate and synergize innovative preventive monitoring and remediation solutions imermaid will build an evidencebased multidimensional framework that will guide policymaking and transform societal perceptions to reduce coec usage emissions and pollution furthermore next generation sensor and remediation solutions will be developed within imermaid to monitor and remove prioritized chemicals from its source while reducing upstream pollution imermaid builds an ideal interdisciplinary team by bringing together prominent smes researchers regulators and innovation professionals who have been essential in improving the knowledge and awareness of coec beyond stateoftheart techniques imermaid will strive to strengthen regulations against coec expand economic possibilities and competitiveness improve the standard of living for eu residents while preventing the accumulation of chemical pollution in the mediterranean sea basin imermaid will empower the efforts to create a zero pollution contaminant free waters by enabling the chemical strategys goals to become a practical reality
hydrogen production by innovative solid oxide cell for flexible operation at intermediate temperature

according to longterm goals of eu renewable hydrogen will become an energy vector for decarbonisation of the eu economy the technology of solid oxidebased electrolysers soel can become a key technological advantage for eu to become a world leader in hydrogen economy the hyspire project aims at further boosting the potential of soel by lowering the operating temperature below 700c and increasing its flexibility in order to fit with res generation profileswithin the project novel cells will be developed towards achieving strict kpis such as low degradation equal to or lower than 075 per 1000 h operation at high current densities ca 12 acm2 and ability to operate dynamically and fast ramping the goal will be reach by the means of developing and applying new materials advanced manufacturing techniques and optimized cell and stack designs the hyspire project will aim at developing oxygen ion and protonconducting cells osoe and psoe respectively on both ceramic and metallic supports therefore analysing broad range of technological possibilities the new cells and stacks will go beyond the soa technology in terms of designs performance and operation the consortium of the project brings together a recognized european stack manufacturer solydera top players in the development of materials for socs expertise in fabrication as well as unique testing capacities and knowhow in technology assessment technoeconomic analysis supported by the lca will be used for the evaluation of project novelties and the market potential the project will cover definition of barriers and research directions to achieve sria objectives such as reduction of hydrogen production cost to 3 kg by 2030 reduction of capex 520 kgkw and opex 45 kgkw moreover the technology of cells and stacks the effects of hyspire will be designed for largescale production and tailored for coupling with res and other industry sectors
next generation zerowaste dynamic multivalorization route biorefinery for sustainable botanical ingredientsshowcasing a replicable and versatile model from extremadura to biobased industry in eu

sustainext is led by natac and brings together 21 partners from europe and spain 7 of them from the extremadura region the project will start in june 2023 and will last four and a half years in summary the technological objective of the project is to implement on an industrial scale a digital dynamic versatile disruptive and multiproduct biorefinery with a processing capacity of 20000 tonnes per year and following a netzero carbon strategy this firstofitskind flagship will transform the plantbased ingredients sector while showcasing and deploying a firstof its kind model likely to be replicable by the whole european biobased industry sustainext aims to transform natacs current production plant located in hervs in the north of extremadura into the most modern digital innovative and sustainable plant extracts factory in the world placing the company and the region at the forefront of the sector at a global level the model is based in the integration of the whole supply chain from feedstock to end users applying a disruptive circular model based on a smart dynamic analytical biorefinery dyana a smart dynamic biorefining process for the cascade valorisation of feedstocks which is optimized batchwise according to the initial composition of the feedstock to deliver maximum value with minimum environmental impact and ensure resource efficiency dyana will allow to achieve the complete valorisation of the processed feedstock with a zerowaste and zeroemissions ambitionsustainext will be industrially deployed with six sustainably and locally sourced european feedstocks three medicinal and aromatic crops rosemary camomile and lemon verbena will be cultivated in extremadura in disused tobacco fields as an alternative towards healthier crops and also between solar panels agrivoltaics enhancing soil use three agroindustrial side streams olive artichokecardoon and pomegranate will showcase how biomass upcycling represents an opportunity to give a new life to certain underexploited biobased feedstockssustainext flagship will deliver 46 plantbased healthy extracts and functional ingredients out of which 13 are totally new on the market and 12 are newly produced in europe it will generate a revenue of 271 m will create more than 5000 new green jobs direct and indirect and will have a decisive socioeconomic impact in extremadura
understanding the age pattern of mortality from gestation to age five years in india

the prevention of stillbirths together with ending newborn and child deaths are firstorder human development priorities sustainable development goals sdg aim to end all preventable deaths before age 5 years by 2030 the research project aims to contribute to this goal by radically enhancing our understanding of human mortality at the beginning of life using novel data and methods suited to study mortality by detailed age before and after birth the innovation of this project lies in its ambitious goal to 1 identify the ages at which fetuses and children are the most vulnerable and 2 identify the underlying factors of such vulnerability the research project is focused on india the home of the highest number of stillbirths and neonatal deaths ie deaths before 28 days of age in the world respectively 340000 and 490000 in 2020 india is also the only large country where under5 mortality is higher for girls than for boys using public and nonpublic data i aim to identify for the first time and with focus on gender discrimination 1 the causes of excess neonatal mortality 2 potential excess fetal mortality and 3 the agespecific impact of climate change on under5 mortality the central hypothesis that i propose to test is the large impact of fetal growth restriction through maternal malnutrition on excess fetal and neonatal mortality the research project also calls attention to the vulnerability of older children above age 1 year to infectious and parasitic diseases that are increased by climate change by providing new scientific evidence and policy recommendations about the agespecific vulnerability of fetuses and children the project will be of significant value to researchers policymakers but also actors involved in field trials of health interventions in india the results of this project will also have policy relevance in a broader context including south asia and subsaharan africa
a land of joiners a gender history of volunteer fire departments in a threeborderregion of east central europe in times of political transformation 19181989

this project looks at east central european ece history by focusing on nonstate actors and particularly on voluntary associations challenging the received view that western europe we and the atlantic world are the authentic cradle of associations and of an appropriate and healthy civil society eg the usa often epitomised as the nation of joiners this project interprets voluntary associations in ece as variation of and not deviation from a uniquebutuniversalized we and atlantic model new studies on associational life in ece suggest that wellestablished theoretical dichotomies like statenonstate governmentalcivil publicprivate need to be overcome and argue that voluntary associations always actively interacted with the political context and contributed to shaping it giomipetrungaro 2019 this research seeks to revisit these theses by focusing on a particular voluntary association voluntary fire departments vfd which in ece exists almost uninterruptedly since the mid19th century under democratic authoritarian or dictatorial regimes alike focusing on social history from below and transnational connections this research will interrogate the question in what way did political ruptures from the end of the first world war until the end of the cold war in ece alter membership structure and gender policies of vfds as well as how did vfds interact and react with the political ruptures in regard to social inclusion and exclusion along the lines of gender the project covers the territories of todays austria hungary and slovenia but more specifically three regions burgenland vas and prekmurje where the concentration of vfd is the largest worldwide by seeking to counter the marginalisation of volunteering within the social histories of ece and of ece within the global histories of voluntary associations the project contributes to the current debates about gender equality and equal participation in the european union
mechanisms of tissue size regulation in spinal cord development

how the organs of a developing organism achieve their correct size and shape is a fundamental unresolved question in biology mammalian embryos possess a remarkable ability to regulate restore the correct size of their tissues and organs upon perturbations during early development yet how this is achieved is unknown addressing this question has so far been challenging because it requires a multiscale approach that integrates precise measurements with theoretical frameworks we are now in an excellent position to unravel the mechanisms by which the mouse spinal cord regulates its size and shape during development by building on our experience with quantitative studies in this system we previously obtained quantitative spatiotemporal data of growth pattern and morphogen signalling dynamics in the spinal cord we showed that there is a critical period during which morphogen signaling is interpreted to specify cell fates uncovered a mechanism that allows precise pattern formation and identified a link between the growth rate and tissue anisotropy our expertise now enables us to address the following new questions 1 how is size regulation in the spinal cord achieved at the tissue and cellular level 2 what is the molecular mechanism of size regulation in particular the role of morphogen signaling 3 how is the regulation of spinal cord size linked to the regulation of its shape to address these questions we will combine precisely controlled ex vivo assays in organoids and whole embryo culture and in vivo advanced mouse genetics and mosaic analysis we will obtain highly resolved dynamic data and interpret it in the context of rigorous theoretical frameworks the project will advance our understanding of the fundamental mechanisms of tissue size control and the constraints they impose in regeneration and disease our results will have implications for in vitro tissue engineering and research on multiorgan coordination and robustness during development
digitallyenabled flexible industries for reliable energy grids under high penetration of variable renewable energy sources vres

flexindustries builds upon a holistic multidisciplinary device process and valuechain and multiscale operating tactical and strategic approach fostering its 6 multisector automotive biofuels polymers steel fertilizers pharmaceuticals energy intensive industries design and deploy the most suitable energy efficiency measures and process flexibility methods for their industrial environments along with a positive impact onto their interconnection with the electrical heating networks flexindustries develops and demonstrates a dynamic energy process management platform to monitor analyse and optimize the most energyintensive industrial processes by managing properly emerging demand response mechanisms and providing plant and process flexibility as well as offering grid services the unique premise of flexindustries is the optimal integration of i innovative energy generation storage and conversion assets eg bess and waste heat recovery solutions based on novel hps orc and heat exchangers systems ii smart and digital tools for optimised operation and control all supported by iii novel business models and market mechanisms for enhanced industrial flexibility overall flexindustries has the potential to save a 159 gwh y of primary energy in total b 60 my life cycle costs on demo scale and c 33111 co2eqy emissions at project level demonstration will take place in 6 industrial facilities in 5 reference countries turkey greece poland bulgaria and italy and will feature a energy efficiency and operational flexibility along with process redesignmodification b increased levels of electrification digitalisation and automation c enhanced user satisfaction and grid flexibility services and d decreased environmental footprint a highly competent team of 16 large enterprises 6 research institutes 8 smes 2 universities and 3 nonprofit organizations are assembled to ensure flexindustries success
sustainable resilient dataenabled offshore wind farm and control codesign

wind energy is crucial for realizing climate neutrality energy independence and energy security with the increased penetration of renewables in the electricity grid there is a strong need for control technology to determine the number of electrons to produce and their destination eg grid storage hydrogen for maximum value to the energy system whereas the technology available on the market exclusively maximizes the energy yield the future lies with optimization for cost of valued energy cove which considers energy security storage fluctuating electricity prices turbine component wear and turbine lifetime therefore sudoco will develop opensource technology for resilient and dataenabled offshore wind farm control and codesign we will use key aspects and insights in wind farm operation to develop the control room of the future that will allow operators to control wind farm output and loads by minimizing the cove sudoco will combine novel dynamic control algorithms hybrid physicsbased and datadriven models for the design of physical farms considering their governing control laws which are safeguarded against adversarial threats and thirdparty fraud our data driven integrated control tool chain will be trained validated and optimized using several highfidelity datasets these include data from fullscale dedicated wake steering control experiments performed at the 69 11mw turbines in the hollandse kust noord wind farm we will also perform unprecedented wind farm control experiments with scaled wind turbine models in the largest boundary layer wind tunnel in europesudoco will target a cove reduction of 10 and includes means to minimize environmental impact as well as address the variability of the wind resource sudoco will deliver the first intelligent integrated wind farm control and design solution for reliable safe and cost effective operation of large bottomfixed and floating offshore wind farms
women entrepreneurs in renewable innovative and sustainable enterprises

the european union leads globally in sustainable and climate technologies yet maintaining this leadership necessitates ensuring broad accessibility across all member states for greentech agritech and climatech innovators despite significant potential disparities persist in gender inclusivity and resource distribution risking the exclusion of certain regions and stakeholders without interventionthe werise project addresses these challenges by empowering underrepresented female entrepreneurs in greentech agritech and climatetech through a strategic blend of funding and tailored support the consortium aims to amplify the market presence of highpotential womenled startups particularly from emerging european economiesthe projects pillars include amplifying market presence through targeted funding and investor matchmaking integrating startups into the ecosystem through crossborder acceleration activities and providing a holistic growth program by prioritising inclusivity diversity and systemic change werise seeks to enhance the impact and visibility of greenwomenled startups contributing to the broader advancement of the european innovation ecosystem towards sustainability
macroeconomic trends and the efficiency of financial markets

financial markets constitute the backbone of modern economies intermediating resources from those who have them ie lenders to those who can put them to productive use ie borrowers a defining feature of these markets is that lenders give up goods today in exchange for a promise to receive goods in the future clearly these promises are only valuable if they are expected to be honoured we can think of promises as being backed by collateral which for the purpose of this proposal i use as a generic term to denote the stream of future income that borrowers can credibly pledge it is an economys stock of collateral that determines the amount and type of promises that can be traded and thus the ability of financial markets to intermediate resources efficiently in past research i have studied the key determinants and effects of an economys total stock of collateral but there is a crucial aspect of the problem that deserves further study in a world of heterogeneous agents what matters for the allocative efficiency of financial markets is not just the overall stock of collateral but also its distribution across firms sectors and countries moreover this distribution is largely endogenous as it is shaped by general equilibrium forces and is bound to change when the economy does in this proposal i focus on three major ongoing shifts in the global economy and their effects on the distribution of collateral and the efficiency of financial markets i declining interest rates ii rising market power and iii shifting distribution of power across countries
de sitter space holography and quantum information

new approaches to de sitter ds space holography open a promising avenue for quantum gravity in ds space simultaneously newly developed quantum information tools allow us to study those proposals and their properties it is the objective of this project to study holography in ds space using quantum information toolsi would like to use quantum information to find an alternative description of ds space in terms of an exact quantum mechanical model for this i will explore different recent approaches to ds space holography including the idea of defining a holographic theory on the stretched cosmological horizon and the use of holographic flow geometries i will use novel measures from the world of quantum information entanglement complexity out of time ordered correlation functions chaos and thermalization and compare their behavior to numerical results for possible candidates of a quantum mechanical dual theory this detailed study will allow me to identify a precise quantum mechanical dual for ds spacethe project will have a major impact on the way we understand quantum gravity in ds space bringing holography from the theoretical realm where gravity lives in a box to a realworld applicable scenario it is further expected that extending holographic quantum information beyond antide sitter ads space to a larger class of theories will draw new and important lessons for quantum information and quantum computationit is the perfect time to conduct this line of research while ds space holography has been a longtime endeavour in theoretical physics progress in lowdimensional holography and quantum information makes it now possible to address it from a novel and concrete point of view i have been a pioneer in applying quantum information tools in ads space and have worked on the new approaches to ds holography i therefore believe that i am the right person to carry out this promising line of research