Dragon09/odtu_chatbot huggingface dataset:
unified modeling and automated scheduling for manufacturing as a service

manufacturing in europe should urgently address the following challenges towards the adoption of the manufacturing as a service paradigm product customisation circularity and sustainability minimal downtime predictive maintenance seamless communication reliability and robustness to uncertainties in demand and variability of resources and cost reduction and performance optimisation unified modeling and automated scheduling for manufacturing as a service unimaas project will develop a platform with a set of advanced technologies for offering flexible and decentralized manufacturing resources and supply chains as a service to european smes and industries to realize this vision the proposed platform will deploy 3 integrated suites i data modelling suite offering manufacturing dataspaces cloudbased resource monitoring trusted crosscompany data exchange and digital product passport ii modelling suite offering modular modeling of manufacturing resources intentbased servitization aibased estimations and zerox analysis and iii decisionmaking suite offering scheduling and planning of manufacturing resources circularity and sustainability optimization the platform will adopt advanced digital technologies such as cloud computing digital twins and trustworthy ai as key enablers towards fulfilling its objectives unimaas platform will provide easy access to customized manufacturing service chain and will support the entire lifecycle management of processes and products the unimaas suites and the platform will be demonstrated in 4 pilots including aircraft maintenance automotive seating 3d construction printing and logisticswarehouse management
aluminum steam combustion for clean energy

metal fuels are emerging as a zerocarbon highenergy density replacement for fossil fuels due to their availability and recyclability using renewable energy aluminum al powder has been investigated mostly in airo2 as an additive in solid rocket engines recently al continuous pressurized combustion in steam has attracted considerable interest for ondemand coproduction of hightemperature heat and h2 combustion in pressurized steam lowers flame temperatures and minimizes emissions of undesirable and hardtocollect al2o3 nanoparticles quantitative understanding of the dynamics of multiphase and multiscale alsteam flames driven by microscopic transport processes phase changes as well as homogeneous and heterogeneous chemical reactions at the particle level is largely lacking asteam will unravel the fundamental properties of pressurized alsteam flames for the entire scientific chain from single particles to turbulent flames with millions of particles through a wellorchestrated combination of highfidelity simulations advanced modeling and tailored experiments we will combine and develop our unique computational capabilities in fully resolved direct numerical simulations frdns at the particle level novel particleincell pic models considering particleattachedparticledetached flames and al2o3 nanoparticle formation carrierphase dns cpdns and large eddy simulations les of turbulent confined flames the unique combination of numerical studies and tailored experiments will lead to a substantial breakthrough in knowledge by quantifying physicochemical processes in alsteam combustion bridging the gap between single particles and turbulent flames our numericalexperimental database of reference alsteam flames together with sciencebased best practice guidelines for future al burners will also empower the broader metal fuel research community and guide future system design and implementation of this carbonfree technology
metabolic optimisation of intratumoral t cell motility

backgroundthe tumor microenvironment markedly limits intratumoral t cell motility and the contact with tumor cells such a defective intratumoral motility of t cells is one of the main reasons explaining why current treatments based on reinvigorationinfusion of t cells to fight human solid cancers are unsuccessful metabolic reactions support t cell migration although t cell metabolism is severely deregulated within different tumor areas how this specifically affects intratumoral t cell motility is unknown this aspect is important since the metabolism of tumorinfiltrating t cells could be in principle easily modulated opening a window of opportunity to improve current immunotherapy approaches against solid cancers whose ineffectiveness is often associated with a poor intratumoral t cell motilityobjectivesi want to understand i which are the metabolic determinants of t cell motility ii how the metabolic alterations within the tme affect t cell motility and iii how to manipulate the metabolism of t cells and car t cells to improve their intratumoral motility and anticancer responsemain methodologiesviable tissue slices from human and murine tumors will be used to measure intratumoral t cell motility realtime imaging microscopy and metabolism multiparameter imaging approaches spatial gene expression histocytometry and to assess the consequences of the manipulation of the metabolic milieu on t cell distribution and motility also car t cells will be engineered with new metabolism modules to improve their infiltration into solid tumorexpected resultsthe findings of this project will provide new insights into i how to improve the metabolic regimen of human solid cancer patients to increase t cell infiltration into tumor islets and ii how to improve the infiltration of car t cells during adoptive cell immunotherapy approaches by modulating their metabolism
role of fluids in rock deformation and the earthquake cycle

the dynamics of the solid earth eg the initiation of plate tectonics the strength of plate boundaries and the formation and evolution of mountains is directly controlled by the chemical and physical action of water in the shallow brittle part of the lithosphere fluid pressure counteracts the lithostatic pressure and weakens faults at greater depth the chemical activity of water makes rocks plastically weaker and is also responsible for metamorphic reactions that induce weakening fluids have been invoked to explain observations of tremor and slow slip at depth and a large fraction of crustal seismicity is attributed to upward fluid flow inducing earthquake swarms yet we still have very few quantitative constraints on either fluid pressure or chemical activity of water at depth in the lithosphere in addition fluid pressure and transport are coupled to deformation and the mechanisms by which fluids induce fault slip and seismicity are not well understood crustal fluids are very mobile and rock physical properties evolve in response to both fluidrock interactions and deformation the aim of this project is to identify and quantify the coupled mechanical hydraulic and chemical processes occurring across the lithosphere from slow creep to rapid earthquake slip and determine the role played by fluids on deep and shallow seismicity slow slip and longterm evolution of plate boundaries i propose to conduct laboratory rock deformation experiments with stateoftheart instrumentation and data processing methods to determine the spatiotemporal evolution of fluid flow and seismicity during faulting quantify the evolution of rock physical and transport properties during longterm healing and test how chemical water activity and metamorphic hydration reactions impact deep fault rheology the laboratory data will allow us to establish the geophysical signature of fluids in the lithosphere and how they impact the dynamics of faults
regulation of gene dosage on the mouse x chromosome

differences in gene dosage can be as powerful as to drive species evolution eg wholegenome duplications and as harmful as to lead to human diseases eg aneuploidies or haploinsufficiencies regulating the effects of genedosage differences is thus extremely critical and this is paradigmatically illustrated by what happens to the x chromosome in mammals in xx individuals one of the x chromosomes is transcriptionally silenced as a result of a developmental and epigenetic process called xchromosome inactivation xci which is presumed to have evolved to compensate xlinked gene dosage between xx and xy individuals since its discovery in 1961 by mary lyon we have learnt much about xci developmental dynamics and molecular underpinnings however very little is understood about the developmental and molecular reasons at the basis of its evolution reguladosix aims to gain a functional and mechanistic understanding of the need of xlinked dosage compensation in mammals we will i determine the developmental and molecular consequences in the absence of xci in mouse embryogenesis and ii functionally identify genes on the x chromosome that are dosagesensitive as well as their functions which would have dictated the emergence of xci in mammalian evolution building on my previous expertise i propose a multidisciplinary approach at the intersection between development and genetic engineering which includes cuttingedge genomic technologies epigenetic screens functional transcriptomics and proteomics and novel approaches that we will develop to tune levels of expression in mouse embryonic stem cells and in mouse models besides bringing new insights into the need for dosage compensation between the mammalian sexes reguladosix will contribute to a quantitative understanding of gene expression and pave the way to establishing fundamental principles of gene dosage regulation in development and disease
reptis responsible extraction and processing of titanium and other primary raw materials for sourcing eu industrial value chains and strategic sectors

reptis offers a sustainable and energy efficient solution for responsible extraction and processing of titanium and other primary raw materials from strategic partner countries to eu supply chains with a net zerowaste approach the project will demonstrate the capability of titanium extraction and processing as a critical raw material in collaboration with strategic partnership country ukraine in all stages of the value chain ranging from open pit ilmenite ore mining and carbonfree ti powder production to fullscale deployment in the eu thanks to the commitments of the industrial partners after the end of the project demonstrating an approach towards zero waste manufacturing by means of energy and resource efficiency and by a validation using real parts from the industry the project will go beyond the stateoftheart in terms of maturity from trl 5 to 7 and hence contribute to the european green deal
usercentered data privacy and utility

personal data are constantly collected and shared via web cites mobile applications like social networking and navigation apps smart home devices like smart tvs and voice assistants and iot devices personal data are then monetized to support targeted advertising personalized services differential pricing risk assessment and influencing public opinion this happens at the expense of privacy and fairness for individuals and the society to address this governments around the world are enacting privacy laws eg gdpr european union and ccpa california unfortunately since profits can be at odds with privacy considerations industry players have an incentive to circumvent the law what is more the technical concepts and associated tools developed so far and used by the laws are neither strong enough nor wide enough in scope last users themselves are conflicted they enjoy the plethora of personalized services but are alarmed by the loss of their privacy in this proposal we advocate for a usercentered approach to privacy where each user may dictate how much privacy is willing to trade in exchange for services we will systematically investigate the efficiency of state of the art privacy mechanisms both formal eg differential and information theoretic privacy and datadriven eg generative adversarial privacy in terms of how well they protect data privacy while maintaining some utility of the obfuscated data and the services that depend upon them we will do so not only via analysis but also via real world experiments in the context of applications at the forefront of personal data privacy leaks we will also introduce novel privacy tools for real world use cases which allow users to select the desired level of data privacy and utility of service use cases of interest include mobile smartphone data leaks online tracking via web browsing and apps usage and user profiling within popular apps like video sharing
horse power interactions between china mongolia and the steppe 20000 bce

horse power will examine the complex interactions between the eastern steppe and china from the second millennium bce to the formation of the xiongnu empire in mongolia and the qin state in china after 300 bce from the second millennium bce two great worlds formed traded and fought across eurasia from mongolia to the european steppe great horse and herding cultures coalesced across thousands of kilometres of grassland to the south a string of states existed from egypt to the chinese central plains some already ancient and others newly created interaction between these worlds was constant and profoundly formative for all parties a fact we are only starting to fully appreciate to examine the connections between the steppe mongolia and chinas central plains we will combine the latest scientific techniques in genetics and metallurgical analysis with theory concerning politics and power within and between china and its northern neighbours three principal empirical elements underpin the project ancient dna from horses the characterization of bronzes to throw light on their movement and recycling the structure and contents of archaeological sites mainly graves in china mongolia and the steppe we will develop theory on the nature of leadership and power particularly in mobile societies science will meet social science in a mutually informative manner and we will work across linguistic boundaries chinese mongolian russian english in a spirit of the coproduction of knowledge with important partners including the emperor qin shihuangs mausoleum site museum in china and mongolian universities we will reflect on our working practices engaging a broader public in how a complex research project works an innovative artistic programme will engage a range of local communities horse enthusiasts and local artists in the work and results of the project working together we will create a picture of this complex region impossible if we had worked alone
spin glasses and random polynomial systems structure algorithms and connections

the project focuses on two areas in the study of random functions in highdimensions mathematical spin glass theory and random systems of polynomial equations research in these fields is currently conducted by two separate mathematical communities the study of algorithms for solving random systems has so far mostly focused on the wellknown 17th problem of steve smale posed in 1998 which originally concerns complex polynomials meanfield spin glass models on the other hand deal with real random polynomial functionshowever smale also posed a real version of his problem even more difficult and much less understood the polynomials in the real version of the problem are exactly the spherical pure pspin models of spin glass theory this creates a bridge between the two theoriesone part of this project sets out to investigate how this can be exploited by using the theory of spin glasses to gain insights into real random polynomial systems and the real 17th problem of smale we offer a new perspective by viewing the problem of solving a system as a problem of minimizing an appropriate energy function a common general problem in statistical physics most importantly this approach allows us to build on recent important developments on optimization of spin glasses and specifically to adapt a hessian descent algorithm originally developed for the spherical models to variants of the real 17th problem of smalethese recent advances on algorithmic optimization were inspired by a new geometric analysis for the celebrated thoulessandersonpalmer tap approach to the mixed pspin models from 1977 in another part of the project we wish to extend this analysis to various other spin glass models and use it to design new optimization algorithms other geometric problems we seek to solve concern the structure and critical points of fullrsb models relations of the tap approach to pure states and properties of the gibbs measure
development of an easytouse interactive platform to renovate training experiences and networking for farmers in the field of sustainable crop management

the renovate project will develop an attractive knowledge sharing platform that provides farmers and agroforesters with unique access to both new and existing training tools and renovated educational programs this platform is designed to increase the exchange of practical knowledge and enhance farmers capacities to achieve sustainable crop management through the uptake of innovationbuilt on attractive and motivating technologies such as serious games and gamified contents therenovate platform will provide farmers agroforesters and advisors with a centralized access to new and existing training resources legislative information applicable best practices practical and real data including costs info about the implementation of innovations in the field of plant protection optimisationrenovate will feed the platform with resources from tools and materials developed by previous eu projects including 14 eip agri operational groups moreover renovate will implement 15 differentadvanced knowledge transfer actions aktas around europe which will generate knowledge ready for practice to be shared through the platformrenovate will then be aligned with the green deal the farm to fork strategy and the new cap as well as the un sdgs for 2030 the consortium involves 16 partners from 8 eu countries that will work together for 48 months with a total budget of 2999998requesting an equal amount of eu contributionwith a total of 444 person months the renovate platform as a unique source for practical knowledge sharing and training material is expected to become a reference for local and national administrations encouraging local farmers and agroforesters to adopt innovation and new technologies for sustainable crop management
food provision through sustainable farming systems and value chains

visionary wants to make a difference in food system transitions by identifying what factors underlie the path dependencies and lockins in current unsustainable food systems and showing how these can be overcome visionary will tackle both policy and business shifts as drivers that are necessary to make a change at the system level the project aims to improve the sustainability of agriculture by promoting practices in food production systems that are more environmentally friendly economically viable and socioculturally appropriatevisionary focuses on existing initiatives practices and policy interventions case studies that are still niche or smallscale and investigates the barriers to scaling up and out case studies cover value chain examples with a differing complexity different environmental policy transitions pathways and existing agrifood system examples namely the shift to organic farming and more plantbased protein production and consumptionat its core visionary uses methods from experimental and behavioural economics to identify barriers and appropriate behavioural interventions nudges education incentives for farmers and consumers the novelty of visionary lies in the combination of experimental methods with a systems thinking approach considering the whole agrifood system as an influence on farmer decisions the innovative combination of quantitative and qualitative data from a variety of methods is our important methodological contribution to more system based research comparability will be achieved by applying the same or similar methods across case studies in germany poland hungary romania italy spain denmark and the ukin order to achieve improved capacities for researchers in behavioural and experimental research as well as for policy makers and value chain actors to utilise such research visionary will work with these actors in sciencepolicyinterfaces set up alongside the case studies
exploring sexbased prey selection during the middle to upper palaeolithic transition in southwestern europe

the extinction of neanderthals after a brief period of coexistence with homo sapiens is a key topic in human evolution and palaeolithic studies to date there is still no consensus on whether differences in diet and hunting strategies between both human populations could have influenced the outcome traditionally archaeologists have addressed this topic by studying faunal skeletal remains determining species variability age of prey and seasonality of human occupations ethnography shows that in addition to these aspects animal sex plays a key role in huntergatherers prey choice procurement decisions as the biological sex of an animal has major implications on its nutritional value its presence in the landscape alone or in a group and its vulnerability the assessment of this factor has not yet been addressed in palaeolithic research but it is essential to understand whether there were strategic differences in hunting behaviour among both human species paleohunters aims to determine the influence of ungulate sex on the hunting strategies of late neanderthals and the first anatomically modern humans groups of northern iberia and southwestern france as both species overlapped in those regions for thousands of years this interdisciplinary project will implement biological sex determination of ungulates by analysing amelogenin a protein present in tooth enamel the resulting ancient protein data will be combined with zooarchaeological and ecological information to reevaluate palaeolithic human subsistence behaviour from the perspective of the biological sex of hunted animals furthermore integrating biomolecular methods has the potential to contribute to address longterm debated issues in archaeological research from new perspectives by achieving these goals paleohunters will put the fellow on an innovative research path where palaeoproteomics becomes an integral part of pleistocene zooarchaeological investigation