Dragon09/odtu_chatbot huggingface dataset:
the fusion and coherence of majorana bound states

the advent of topological materials has shaken the field of quantum physics bringing with it the prospect of nonlocal states that exhibit nonabelian exchange statistics a promising candidate for a topological state is a majorana bound state mbs whose nonlocal nature makes it impervious to local noise and whose state can be manipulated by changing the topology of multiple mbss this topological protection brings with it potential gamechanging quantum computing applications the last decade has been marked by significant advances in the field which have resulted in many observations through dc transport that are consistent with the presence of mbs however the dc transport characteristics of mbss are very similar to trivial andreev bound states and consequently clear evidence of mbss has thus far not been observed the fusiorana project aims to unambiguously demonstrate the existence of mbss by probing their coherent properties moving past dc transport timedomain techniques will be employed to observe the lifetime of mbss their behavior when fused together and finally to control their quantum state and measure their coherence the findings of this project will reignite the field of topological quantum physics spurring a next generation of experiments exploring coherent properties of nonlocal mbss it will also place mbss as a prime candidate for a future quantum computer the combination of expertise and infrastructure make the university of copenhagen an ideal host institution for the proposed research project the project will be supervised by c marcus and cosupervised by f kuemmeth their combined knowledge on dc transport majorana physics and timedomain control and readout perfectly match the topics of this project the project also builds upon the existing mbs experiments in the group of c marcus which have thus far been responsible for many of the key developments in the field of mbss
protacdriven protein degradation by proteasome during antigen processing and presentation proapp

proteolysis targeting chimera protac is a new and attractive therapeutic approach that regulates a target protein by channeling it to the proteasome for degradation an energydemanding pathway concurrently proteasomes also play a central role in generating the peptide repertoire for antigen presentation on the human leukocyte antigeni hlai molecules a few years after protac was invented proteasomes were found to catalyze not only canonical peptide bond hydrolysis but are also capable of cutandpaste events ie generating spliced peptides which have been shown to be frequently presented n hlai immunopeptidomes it is unclear how protacdriven proteasome degradation modulates the spliced and nonspliced peptide repertoire derived from a targeted protein alterations in peptide variety and quantity produced by proteasome may lead to strong implications on the hlai immunopeptidome and hence could result in immune implications therefore using the key oncoprotein kras as a protacs target this study intends to understand i how protacdriven kras degradation affects cellular pathways on a systemwide level ii the impact of protac on kras derived peptide repertoire generated by proteasomes iii to what extent protac enhances kras derived peptide presentation on hlai molecules through the combination of a multidisciplinary approach molecular biology biochemistry proteomics bioinformatics and cellular immunology this study will provide a better fundamental understanding of the effect of protackras on the cellular proteome proteasomederived peptide repertoire spliced and nonspliced peptides and hlai immunopeptidome landscape thus provide insights into the suitability of protackras application as a therapeutic approach for anticancer therapies additionally this project will deepen our understanding of the role of spliced peptides in the antigen processing and presentation pathway
crystalline oxides for next generation computing and emerging photonic technologies

continued evolution of ict is stalling as a result of inherent limitations in traditional silicon semiconductor technology still the needfor more powerful and less energyhungry electronic devices remains fastgrowing at the same time new technology needs toadhere to a higher standard of sustainability we need new materials new devices and new deployment of technology to overcomethese obstaclesconcomitantly european rleadership within electronic components and systems ecs is at a low underpinned by the chip crisis duringthe last few years and confirmed by the launch of the european chips act europe is at a crossroad should it remain a passive playerin global ict or take a leading role in the development of new technology the concept team strongly believes that we need totake a new perspective and strengthen the whole value chain of european ecs from research to industry securing an active andleading role in future paradigmsconcept aims to take a leading role in this endeavour utilizing the strengths of excellent european partners within chemistrymaterials science device physics and device engineering we choose an innovative and unexpected approach by proposing the useof atomic layer deposition ald to enable lowtemperature integration of epitaxial functional complex oxides in neuromorphic andphotonic devices concept will confirm the vital place of ald in the ict value chain by constructing proofofconcept neuromorphicand photonic devices that will boost development innovation and entrepreneurship in the field sepcifically targetting kso c andkso a as laid out in the horizon europe work programmeconcept will furthermore encourage participating smes and industry to take a leading role in this development directly building onproject outcomes this will generate growth create value and secure european entrepreneurship and leadership within ecs
boosting circular systemic solutions through virtual regional circular economy spaces

cssboost aims to overcome technological and nontechnological ce barriers minimise css application and operational risks and decisively stimulate and maximise the circular economy and bioeconomy transition in any eu cityregion or group of regions to pursue this cssboost develops a novel css application framework that views a css as a composite living entity that operates and evolves within a cecss ecosystem and market an open physical space of city regional or multiregional scope encompassing an areas existing ce market its value chains and its entire external environment even extraregional entities and markets it also introduces the methodological concept of the cssboost integrated solution that involves the integration of one or more css within a digital environment enhanced by tailored methodology and procedures this physical system is virtualised monitored analysed and assessed by developing the key cssboost innovation the virtual regional cecss ecosystem and market vcem cssboost designs a set of diverse exemplary csss both as transition tools and to validate and promote its ideas by applying and demonstrating them in five city regional and interregional pilot cases the exemplary csss respond to different challenges barriers needs and feasibilities across eu and target different product value chains as delineated in the eus circular economy action plan water food and nutrients plastics batteries vehicles cssboost develops both its innovations and pilots by applying a rigorous sota cocreation environment and instruments and ssh methods and procedures it also develops replication organisational business and exploitation plans for the uptake replication and upscaling of its solutions as well as education and training programs and social innovation actions
laser biofabrication of 3d multicellular tissue with perfusible vascular network

building 3d vascularised organs remains the major unsolved challenge to be overcome in biofabrication and tissue engineering establishing blood vessels capable of efficient transport of gas nutrients and metabolites to and from cells is a prerequisite for the survival of tissue constructs both in vitro and when transplanted in vivo high resolution multiscale constructs are necessary to replicate the complexity of functional vascular perfusion from large scale arteries and veins to micron scale arterioles venules and capillaries using a unique combination of advanced laser bioprinting with twophoton polymerisation technique a full vascular system may be generated by exploring different scaffoldbased scaffoldfree sacrificial and hybrid approaches for the generation of a complex vasculature with functional layers and extracellular matrix the connection of artery and vein with engineered vascular tree including capillaries have received little research attention despite the crucial requirement to reliably connect perfusion inlets and outlets to a pulsatile flow system this is essential not only to perfuse tissue but to stimulate and control maturation of engineered tissue in reaching the condition required to function with realistic biophysical characteristics of thick tissue outside of a closed incubation chamber computercontrolled generation of a 3d vascular capillary tree and achieving its perfusion in centimetre scale cardiac and skin tissue constructs using the developed biofabrication methodologies will represent a seminal breakthrough in organ regeneration with widespread longterm impacts across the field of regenerative medicine
medieval appetites food plants in multicultural iberia 5001100 ce

the islamic conquest of iberia in the 8th century brought in profound changes in the political social and economic realms that transformed the everyday life of local rural and urban communities technological innovations and the arrival of new crops impacted their agriculture diet and culinary practicesplants were present in almost all aspects of medieval peoples ordinary lives food crafts medicines etc however they have been commonly sidelined in discussions of the past most of what we know about plants in this multicultural period in iberia is based on a limited number of archaeobotanical studies and on written sources which despite their undeniable value they often reflect issues related to the elites by contrast archaeology and more specifically archaeobotany and their associated sciencebased techniques are placed in an extraordinary position for approaching issues related to plant production processing preparation and consumption and how these connect to broader societal changes by integrating archaeobotany and written sources as well as applying groundbreaking techniques plant genomics and food remains analyses medapp aims to disentangle what range of plants were used in medieval iberia 6th11th ce where new species came from and when were they introduced who brought them and how people engaged with them through different practices the project sets a new holistic agenda for understanding the impact of the new political economic and social system on agriculture eating habits and culinary practices of iberian medieval communities this project aims at providing a stepchange in the way agriculture plant production preparation and consumption have been studied in medieval iberia it represents a golden opportunity to fill the voids of texts looking for clues in the archaeobotanical record an occasion to approach with a suite of scientific and innovative methods the unspoken information contained in these silences
tunisian wellbeing through inclusive science

following the green night project in 2020 and lila jemila which gained associate event status in the 2018 european researchers night twise night is tunisias third initiative the idea for twise tunisian wellbeing through inclusive science night was put forth by an assortment of scientific researchers and scientific communication specialists from the research and innovation community as well as key players in ri and organizations the primary objective of the project is tofollowing the green night project in 2020 and lila jemila which gained associate event status in the 2018 european researchers night twise night is tunisias third initiative the idea for twise tunisian wellbeing through inclusive science night was put forth by an assortment of scientific researchers and scientific communication specialists from the research and innovation community as well as key players in ri and organizations the primary objective of the project is to promote public awareness of research and innovation initiatives that contribute not only to environmental sustainability but also to the enhancement of societal wellbeing and the fostering of inclusivity the arsii association a key participant in the initial two ern editions with the ministry of higher education and scientific research collaborates closely with the react association and four prominent tunisian universitiesnamely the university of sfax the university of carthage the university of sousse and the university of monastir they share a profound understanding that researchers play an essential role in the community and their work is not only engaging and stimulating but also rewarding and worth pursuing in order to accomplish these goals twise night 2024 will take place in sousse which is known as the pearl of the tunisian sahel followed by twise night 2025 in tunis preevents and researchers at schools will also be hosted in sousse monastir and mahdia as well as in sfax and tunis
an integrated approach to enhance food systems resilience advocating for food security and uninterrupted food supply

securefood adopts an integrated systemsthinking approach that acknowledges and embraces the complexity of food systemsaddressing them as an interconnected network of actors elements activities processes infrastructures and essential services related to the production and delivery of food based on this approach it brings together as consortium partners multiple actors of the food supply chain itself such as producers food and beverages industries retailers and consumers but also actors supporting the functioning of the supply chain such as bulk carriers and road transport carriers the actors network also includes ministries and entities operating under their auspices responsible for coordinating national resiliencebuilding effortsthe ultimate goal is to address the aforementioned food security challenges by creating an ecosystem of scientific knowledge collaborative processes and digital tools this ecosystem will provide evidencebased indications on the risks and vulnerabilities of different value chainsgrainfruits vegetablesfish aquaculture productsmilk dairy productsin different geographic contexts and will contribute in a structured manner to the safeguarding of food security before and during crises and to the reinforcement of food systems resiliencethe cornerstone of securefood will be a food systems resilience management framework with interlinked resilience and sustainability orientations as well as a resilience governance framework that draws on collaborative principles and adopts inclusive and participatory processes to ensure successful cooperation between experts and stakeholdersthe securefood ecosystem will be developed tested and demonstrated for different case studies one of which addressing a currently ongoing food security crisisie ukraines grain value chain that has been severely impacted by russias invasion and the disruption in grain shipments that has pushed millions people into poverty or food insecurity
truth in ancient and medieval philosophy

while it is sometimes suggested that we are living in a posttruth age wherein the concept of truth is increasingly less relevant truth nonetheless remains a central concept in science ethics and ordinary life however what precisely is truth one common view the socalled correspondence theory of truth maintains that truth is simply correspondence with the facts however such a view faces a number of difficulties and potential objections for instance what exactly is correspondence and what exactly are facts moreover if truth is simply correspondence then why it is the case that correspondence comes in degrees whereas truth is usually agreed not to and how should we deal with certain semantic paradoxes such as liar paradoxes which suggest that our conceptions of truth are internally inconsistent the notion that truth consists in correspondence goes back to antiquity and the middle ages however although past philosophers discussed the nature of truth in significant detail and with considerable philosophical sophistication our understanding of past theories of truth is surprisingly limited and we lack a clear idea of how notions of truth developed in later antiquity or in the arabic and latin medieval traditions this project will offer the first focused and systematic examination of philosophical conceptions of truth in ancient and medieval philosophy it will examine the origins motivations and challenges faced by conceptions of truth in this period and how these challenges led to the development of alternative theories of truth by holistically examining both major and minor figures and texts in this period and combining metaphysical approaches to truth with logical and semantic approaches this project will offer us a better understanding of a central philosophical issue across the greek arabic and latin traditions and greater insight into an extremely rich but often neglected period of philosophy
what determines the hierarchy of vsg antigen switching in t brucei

pathogens use antigenic variation to evade host antibodies and cause diseases in humans interestingly in many species antigen switching occurs nonrandomly in a hierarchical manner with specific antigen genes selected in succession trypanosoma brucei is a key model organism for the study of antigenic variation in which antigen switching hierarchies of its variant surface glycoprotein vsg genes operate however how exactly this hierarchy is determined is unknown studies in t brucei have indicated that the spatial positioning of vsg genes within the nucleus is important for controlling their activation however to date no systematic investigation of vsg gene nuclear positioning and antigen switching hierarchies has been performed in this project i would test the hypothesis that antigen switching hierarchies in trypanosomes are mediated by the spatial positioning of vsg genes in the nucleus using t brucei cell lines in which different antigen switching pathways can be induced i will determine whether silent vsgs in close spatial proximity to the active vsg before switch induction are selected next in the antigen switching pathway this will be investigated by integrating a combination of microc to monitor vsg nuclear positioning before and after switching followed by scrnaseq i will also develop a dcas9 artificial tethering system to tether silent vsgs either towards or away from the active vsg before switch induction to create a synthetic vsg switching hierarchy these experiments will generate important insights into the mechanisms which control antigen switching and provide valuable tools for studying nuclear organisation in kinetoplastid parasites
dynamical tests of dark matter in local group galaxies shortcomings and new avenues

the distribution of dark matter in the milky way and neighbouring local group galaxies is an important indicator of the nature of dark matter accurately determining the smooth distribution of dark matter in these galaxies and the degree of clumpiness abundance of luminous and dark satellites encodes information about the properties of dark matter and the interplay between the baryonic and dark sectors in the formation and evolution of galaxies as well as being auxiliary quantities in interpreting the results of multichannel dark matter searches thanks to significant investments in observational resources by international and in particular european countries we now have access to an enormous amount of detailed highquality astronomical data that allow us to view local group galaxies as complex systems in interaction with their environment the dialogues project will help harvest these exquisite datas full potential in interdisciplinary dark matter searches with a hybrid approach on the one hand we will address biases in the smooth galacticscale distribution of dark matter in current chemodynamical models of the milky way and neighbouring dwarf galaxies on the other hand we will search for peculiar features in the spatial distribution and kinematics of individual stars in local group dwarf galaxies which will then be confronted with signatures of luminous and dark mergers in stateoftheart hydrodynamical simulations in this way the theoretical link between observations and the accretion history of the host dwarf galaxy will be provided dialogues will be a transferofknowledge agent between the astroparticle and astrophysics communities contributing to the interdisciplinary endeavour to constrain the underlying particle physics model that governs dark matter at the microscopic scales
novel digital components for international renewable energy value chains

the orion vision is to strengthen the european leadership in science and technology and accelerate the twin energy transition of theenergy value chain stakeholders with a quintuplehelix model by delivering a modular toolbox of digital breakthrough componentsby validating these components in the unique use cases of hydro solar and wave energy operations across four continents and byintegrating and presenting these novelties in a humancentric digital twin applications to enable a higherdegree of digitalisation ofrelevant operational and business processes increase the renewables share in the electricity grid globally and reduce fossil fuelsconsumption in the context of an increased demand for energy resources and uncertain geopolitical and climate conditions in thelong termthe developed digital components will help the stakeholders to tackle different limitations of the energy value chain with the goal tomake energy more sustainable affordable and safer and thus solve pressing prioritised political business and societal problemsthe humancentric digital twin will empower better informed decisionmaking of the stakeholders including policy makers allowingthem to share insights in a collaborative and virtual environment the digital twin will help to address the energy stakeholders needsin a comprehensive manner and will include the latest knowledge and best practices from the existing eu platforms eg enersharegaiax and fiwaretoplevel research and innovation entities from 8 countries france germany norway portugal slovenia brazil canada and capeverde spanned across 4 continents will jointly contribute to high impact ri implement testing and validation activities in fiveunique use cases contribute to a better education output and develop new multidisciplinary knowledge to be translated intosolutions services and products to be applied across the energy valuechains globally