Dragon09/odtu_chatbot huggingface dataset:
dissecting the molecular regulation of hematopoietic stem cell emergence using pluripotent stem cells to improve ex vivo therapies

although hematopoietic stem cell hscs transplantation is routinely used to treat blood disorders immune incompatibility and donor shortage remain critical clinical barriers likewise since high number of hscs are needed for successful transplants the absence of reliable expansion protocols prevents the wider application of this cell therapy in fact while hscbased gene therapy represents a revolutionary treatment also for novel and unexpected indications the ex vivo manipulation required for hscs engineering results in loss of their stemness potential patientspecific induced pluripotent stem cells pscs could serve as a solution to these problems as they would provide a potentially unlimited easy to engineer source of immunologically matched hscs however despite recent advances the robust de novo generation of hscs remains unrealized due to an incomplete understanding of how hscs are generated during embryonic development a process that as such cannot be accurately recapitulated in vitro to tackle these issues in this proposal we will leverage on our proven expertise in psc differentiation and hematopoietic development in particular we will use innovative in vitro assays and systematic measurements to determine at the molecular level how hsc precursors control their gene expression to generate blood cells aim 1 combining the study of the highly proliferative emerging embryonic hscs with a crisprbased gainoffunction screen we will uncover the molecular regulators of the extensive embryonic selfrenewal thus enabling robust specification of hscs from pscs aim 2 we will design strategies to resurrect this embryonic selfrenewal program in postnatal hscs for their in vitro expansion aim 3 the successful completion of these studies will accomplish the longstanding goals of generating and expanding hscs in vitro allowing the fully exploitation of the transformative therapeutic potential of hscbased cell and gene therapies
empowering physicians to provide every stroke treatment with the right treatment in time with strokeflow

stroke patients represent the most time critical field of emergency medicine every minute counts when it comes to stroke every minute delay in treatment leads to 22 healthy days lost no comprehensive solution exists that solves the lifethreatening bottlenecks in the complex stroke acute care chain resulting in 13 of patients dead and 13 becoming disabledthe main challenge is that stroke care specialists are essentially treating in the dark they lack the speed to share accurate patient data in realtime with colleagues and they have no readily accessible information at all about the blood clot causing the stroke all stroke patients are inevitably treated ineffectively in a one size fits all approach as physicians go in blind every intervention it is our mission to empower physicians to treat every stroke patient in time with the right treatment with strokeflow we for the first time enable this with groundbreaking technology and innovative solutions
6g short range extreme communication in entitites

the 6gshine project will pioneer the main technology components for inx wireless subnetworks short range low power radio cells to be installed in a wide set of vertical and consumer entities like robots vehicle production modules classrooms for the sake of supporting extreme communication requirements in terms of latency reliability or data rates 6gshine will leverage the opportunities offered by the peculiar deployment characteristics of such short range subnetworks for a highly performant yet costefficient radio design that allow to bring wireless connectivity to a lever of pervasiveness which has never been experienced earlier 6gshine copes with topics new iot components and devices and new physical layers and associated protocols of strand b0103 in the sns work programmeresearch will span physical layer medium access control protocols radio resource management of these inx subnetworks as well as connection with a broader 6g network of networks the performance of the designed solutions will be analyzed via simulations and for selected technologies over demonstrator platforms the project will result in a broad set of technology solutions that will be disseminated via scientific publications also the designed solutions will be brought to future 6g standardization and will be used in future telecommunication equipment and networks the consortium consists of 12 partners that together bring essential expertise to each of the identified technologies with a mixture of academic institutions and industry players with a strong research department representing the essential parts of the value chain of wireless short range communications
extinction replacement and trade tracking 100000 years of horse evolution in iberia

horses provided humans with the ability to travel well above their own speed and changed the way they made war as such the domestication of the horse 5500 years ago represents a historical turning point in human history throughout the whole upper palaeolithic period and right into the holocene iberia has always offered favorable climatic conditions for equine populations to thrive much remains to be discovered on the horses that once roamed the region for instance the true nature and diversity of the iberian horse represented in the famous cave paintings of altamira remains unknown the exact dynamics underlying their replacement by foreign domestic horses during the bronze age is also debated similarly while the muslim expansion of the c7thc9th is known to have reshaped the genetic makeup of horses across europe the exact impact of this expansion in iberia is unknown despite muslim kingdoms being maintained there up until the c15th the same holds true for previous equine civilizations such as the phoenicians who traded in the area or the romans who largelly expanded into the region finally the true extinction timing of the iberian zebro an european wild ass closely related to asian hemiones is contentious with some scholars advocating survival up until the middle ages by focusing on a single region iberia the zephyrus project provides the unique opportunity to solve many longstanding debates in horse evolution and prehistory through the development of innovative genotyping solutions and stateoftheart approaches in ancient dna research zephyrus will genetically predict how the physical traits of iberian horses have changed since the upper palaeolithic and how different equine civilizations have remodelled the iberian horse through space and time reciprocally zephyrus will unveil the influence that iberian horses have had an how they contributed to reshaping the genetic makeup of other european regions
exploring wooden materials in hybrid printed electronics a holistic approach towards functional electronics with net zero carbon emissions

reshaping the lifecycle of electronics from raw materials to endoflife is inevitably one of the fundamental steps to accomplish towards a sustainable economy and society the ambition of the hypelignum project is to propose and demonstrate a holistic approach from sourcing of raw materials until the endoflife of devices for the manufacturing of electronics with net zero carbon emissions centred around additive manufacturing and wooden and wood derived materials ie bioderived or biopolymers from wood waste wood has been identified since it is a largely available and technically versatile material which has and will keep having a key relevance in constructions and households new european bauhaus initiative furthermore its biogenic nature makes it pivotal in the european community effort toward a carbon neutral society hypelignum pillars are i implementation of the biogenic material wood as substrate for the additive manufacturing of electronic ii implementation of lignocellulosic materials from wood production waste bioderived resins and abundant and low impact transition metals in the needed functional materials iii the development of highly energy efficient chip for driving integrated sensing systems iv exploring new avenues for allowing the recycling of wood and recovery of electronic materials importantly in addition to the technical development the project will also dedicate a significant effort in the sustainability assessment life cycle toxicity and biodegradability to i contribute actively to the consolidation of the definition of green and circular electronics and ii to propose a decisionmaking tool for assessment of green and circular electronics
next generation internet for all evolution growing a sustainable and inclusive ecosystem

ngi4alle aims to support ngi communication marketing and community building helping the ec to engage a diverse community of stakeholders spanning from researchers and innovators to policy makers and end users by building on the experience gained by running the ngi outreach office ngi4alle will guarantee continuity of several essential activities while injecting new ideas tools and actions based on the evolution of the demand and of the overall ngi context it will strengthen and grow the ngi ecosystem in a sustainable and impactful way maximizing and amplifying work and results of ongoing ngi projects while attracting to the initiative newcomers especially from underrepresented groupsareas ngi4alle will help sharpen the ngi vision and tie it to broader conversations about the development of ethical humancentred digital technologies improving ngi visibility accessibility and relevance towards nontechnical audiences in larger and more diverse contexts
the roman turn among jews greek pagans and christians

romana aims to unveil the ubiquitous presence of rome in jewish greekpagan and christian texts and to expose the strategies of cultural interaction between imperialist forces and a range of minority groups it will explore how intellectual discourses that have defined the west namely those of greek elites christian groups as well as hellenistic and rabbinic judaism were constructed through a series of contested hidden and disavowed interactions with the dominant force of empire the project will redraw the traditional map of the roman empire to challenge its sharp dichotomy between rome and the provinces and demonstrate the deep entanglements of each group of provincial elites despite their claim to cultural purity the starting point is firstcentury hellenistic judaism as its main representativesphilo and josephusbecame active in rome as prolific authors writing in greek who combined philosophical literary and legal interests with a keen appeal to roman audiences their modes of acculturation will serve as a compass to unlock similar cultural entanglements in the second sophistic early christianity and rabbinic literaturethe project objectives entail a focused study of three trajectories philosophical literary and legal to be exposed as doubly entangled namely with each other and with roman discourses the method will be a close comparative and culturally aware reading of whole corpora of texts in greek hebrewaramaic and latin based on the available manuscripts moving through greekchristian writing into rabbinic judaism and the texts that contest the space between them we will reach insights of a new order in fields which have thus far been overwhelmingly studied in double isolation or on the limited basis of digital searches of keywords the results will be published in 6 monographs special issues in leading journals a consultation at an international conference and wide dissemination in israel up to changes in school curricula
entangled flying electron quantum technology

the elequant project proposes a paradigm shift in quantum technology by exploiting flying qubits presenting a transformative alternative to mainstream approaches such a superconducting or semiconducting qubits while photonbased flying qubits face challenges in realtime manipulation and interaction due to their fast propagation speed and weak photonphoton interaction elequant aims to harness the potential of electronic charges for superior scalability and connectivity through pioneering research in the manipulation of electronic wavepackets in semiconductor nanostructures the project strives to achieve the ambitious goal of realizing highfidelity flying charge qubits and demonstrating entanglement between them key objectives include the development of novel quantum materials platforms based on strained ge and multilayered graphene by establishing a comprehensive roadmap for solidstate flying qubit technology elequant seeks to accelerate innovation in quantum technology and foster collaborative partnerships with industry stakeholders on a european scale with a focus on scalability connectivity and coherence elequant aims to propel quantum technology into a new era of unprecedented capabilities and applications
population medicine and sustainable development european opportunities in collaborating with china to improving global health

the overarching objective of this staff exchanges se program is to form an international network of organizations from spain germany slovenia and china working on a joint research program in the fields of health development economics and anthropology population medicine is a new medical paradigm that aims to improve the aggregate and longterm population health by mobilizing available resources through various care responsibilities the principles of population medicine are aimed at forcing doctors and physicians to shift from a reactive model that treats ill individuals to a proactive model that focuses on the populations health this se program focuses on how economics as a collection of theories models techniques and values might enable practitioners in providing better and more efficient treatment to the population they serve the peoples republic of china has become a global leader in largescale preventive screening and the digitalization of healthcare making essential strides towards a population medicine paradigm23 researchers will conduct 144 pms of secondments in training data collection and research work in the four countries to develop an economic framework for population medicine estimate the causal impact of renewable energy and digital telecommunications infrastructure on sustainable development outcomes and conduct a social and cultural analysis of the effects of health and sustainable development policies on european immigrants in chinathe results will enable european and international medical training institutions to develop better programs and solutions to target and improve the aggregate health of their respective societies it will bring together these existing collaborating partnerships into an interdisciplinary consortium that synergizes the intersections of their complementary research lines of health sustainable development and cultural integration through the training and staff exchange programs
engineering biological signaling pathways using synthetic cells

facing the challenges of the xxist century related to climate energy and health requires the development of new biotechnologies synthetic approaches of biology represent an opportunity for applications where living cells are inefficient inadapted or undesired yet only cells can make cells remains to date an unrefutable fundamental reality and constructing de novo living systems represents the new frontier of biotechnology the it industry developed over the years highly complex and integrated microsystems based on building blocks such as the transistor and fundamental principles of electrodynamics and quantum physics the analogon for biology must still be unraveled to develop the biotechnologies of the next century our aim is to produce lifelike systems of synthetic cells in interaction with their environment we will train doctoral candidates to develop a toolbox of experimental building blocks based upon soft microcompartments molecular transporters dna nanotechnologies optical technologies and microtechnologies for the construction and integration of large population of interacting synthetic cells because they are built from scratch with a highlevel of functional characterization and control these cells will allow to unravel fundamental principle in life complexity and at the same time become integrable building blocks analogon of the transistors of the it industry of a new type of biotechnology they will pave the way for applications of synthetic cells addressing the pressing needs of the xxist century in energy harvesting biomass and raw matter transformation bioremediation or therapeutics our network based upon interdisciplinarity in research and innovation will train the next generation of independent and responsible scientists to address pressing global challenges through the build up of fundamental knowledge and sustainable innovations
which factors drive macroevolutionary rates of speciation and extinction

biodiversity is modeled by the process of speciation and extinction there is clear evidence both from living and extinct species that biodiversity is extremely variable through time and among species however we still do not know what factors eg environmental or species intrinsic drive speciation and extinction rates on a macroevolutionary level to complicate matters species diversification models are not identifiable that is there are infinitely many combinations of continuous speciation and extinction rate functions that are statistically indistinguishable first i will extend previous diversification models to jointly infer timevarying and lineagespecific diversification rates using phylogenies of extinct and extant taxa second i will tackle the nonidentifiability problem and explore which patterns eg rapid increases in diversification rates and mass extinctions can be inferred third i will use a combined paleophylogenetic approach and estimate diversification rate from phylogenies with extinct and extant taxa thus i will combine statistical computational neontological and paleobiological approaches to study macroevolutionary dynamics i will produce specieslevel phylogenies each carnivora cetartiodactyla crocodyliformes and squaliformes using novel morphological datasets and models i will test if diversification rates are correlated with environmental factors eg co2 or temperature or species specific traits eg body size and life history traits ultimately we will test if specific traits are correlated with mass extinction survival probabilities as for example the lilliput effect predicts smaller species to have higher survival probabilities
diversify ccam by integrating the european cultural and regional variations in the design and implementation of citizenfriendly systems to foster mobility equity

ccam solutions face a significant challenge characterized by decreased societal demand due to their difficulty in effectively conveying their advantages within existing mobility systems and adapting to the diverse environments where citizens live work and conduct their daily activities diversifyccam has the clear objective to promote fair and accessible mobility in european regions by integrating cultural geographical and policy aspects into the design development and implementation of ccam solutions this initiative encompasses 6 european countries czech republic greece italy germany spain sweden collectively hosting 12 pilot sites dedicated to data collection and evaluation in each country there are two distinct areas under examination one focusing on mobility of people within urban environments equipped with existing ccam solutions and another focusing on mixed transport people and small goods solutions within rural or touristic areas primarily reliant on private cars diversifyccam will deepen our understanding of the diverse social contexts that influence the acceptance adoption and utilization of ccam moreover the project will study the surmount challenges and barriers hindering the effectiveness of shared services especially in regions with unique geographical and cultural demands the methodological approach involves the engagement of various user groups and stakeholders at the local level extending their involvement to the european and international spheres through pave and our distinguished stakeholder board this multifaceted involvement aims to positively influence public perception and reimagine the overall design and offerings of ccam solutions ultimately the project will develop a ccam diversification tool ccam dtool for transportation planners and a ccam diversity observatory for the entire ccam value chain both focusing on achieving inclusiveness and equity within the european mobility ecosystem
transculturality and social innovation in frontier areas of preroman italy

fundamental transitions in societies can be caused by several factors amongst those human connectivity can have a pivotal role the tular project focuses on human mobility and transculturality the coexistence of diverse culture in archaeological sites investigating their impact on cultural and political dynamics in ancient populations of preroman italy the project will combine traditional archaeology the analysis of funerary ritual and material culture and cuttingedge scientific tools multiisotope adna and data analysis to provide a new understanding and novel instruments for interpreting the dynamic of interaction formation and development of emerging complex society in the mediterranean the etruscans of preroman italy are optimally suited to exploring this phenomenon having woven webs of networks across the peninsula and experienced considerable sociopolitical changes eg the passage from villages to cities in their formative phases tular etruscan for border examines principal protoetruscan frontier sites where fluctuation in transculturality is commonplace despite all being initially part of the same network those sites experience diverse cultural and political outcomes suggesting variation in network development and offering the optimal dataset for the study tular will revise the traditional narrative of the etruscan civilisation so important for contacts in temperate and mediterranean europe providing a compelling reworking of our understanding of the european iron age meanwhile it will offer a methodological blueprint for studying transculturality and sociopolitical development globally framing new directions in research on mobility and its impact on ancient societies