Dragon09/odtu_chatbot huggingface dataset:
buddhism diplomacy and travel identity and nationbuilding in bhutan

this research project is an investigation of identity and nationbuilding in eighteenthcentury bhutan with a particular focus on the agency of buddhist masters as important diplomats and bhutans entangled history with tibet this will enable a novel understanding of bhutans religious and political history particularly its buddhisminduced development model of gross national happiness gnh that has not yet received systematic historical analysis in religious studies in europe despite its global popularity as an example of alternative sustainable economic models furthermore for the first time bhutans historical role in linking south asia the british raj and east asia will be systematically addressed the research output will significantly advance both fields that of tibetology and religious studies the innovative research design combines historicalphilological methods by analyzing a thus far untranslated corpus of bhutanesetibetan primary sources with a theoretical framework from religious studies focusing on identity and social differentiation therefore the project is in its methodology output and impact interdisciplinary the researcher will produce a draft for a single monograph publication for habilitation in germany the proposed project involves as the researcher a german tibetologist trained in germany canada india and bhutan reintegrating to germany to work with a religiousbuddhist studies scholar at leipzig university this will enable substantial training for the researcher in religious studies and impactful twoway knowledge exchange between the researcher and the host institution due to the international experience of the researcher an intersectional secondment at the british library endangered archives programme london will provide further tibetological training in digital archival work palaeography and codicology and produce globally accessible research data about this digitized bhutanesetibetan primary source corpus
surrogate modelling for 3dprinted achromatic high numerical aperture metafibres

with the proposed research project i aim to revolutionize optical metasurface design leveraging surrogate modelling techniques obj1 towards the development of 3dprinted achromatic high numerical aperture na metalensenhanced fibres called metafibres obj2 the proposed methodology consists of three interconnected phases firstly wp1 constructing a supercell metaatom library consisting of threedimensional metaatoms through iterative optimization the simulated designs will be 3dprinted and the simulation model updated based on the results of the experimental characterization ensuring precise and realistic control of metaatom responses secondly wp2 a gaussian process regression gpr will be implemented as a versatile surrogate model using the established supercell library this machine learning technique enables the efficient prediction of complex optical meta supercell responses facilitating rapid prototyping and customization with reduced computational overhead notably gpr models allow to consider fabrication tolerances straightforward in combination with data augmentation techniques lastly wp3 i will exploit the gpr model for the design of highperforming achromatic metafibres utilizing 3dprinting technology to directly print the metalenses on the tip of optical fibresi have chosen a top research centre leibniz institute of photonic technology jena germany to develop my msca project under supervision of a worldleading expert in optical fiber photonics using my knowledge in engineering photonics and numerical simulation tools this msca project will pave the way for metafibres promising versatile and broadband optical solutions with the potential to transform fields like microscopy telecommunications and medical imaging this research aligns with sustainability goals by minimizing material waste and energy consumption in the fabrication process marking a significant advancement in metasurface and optical system design
a cyanobased consolidation technology for a green conservation of stone heritage

outdoor stone monuments in europe and beyond cant be preserved with conventional consolidation methods without risking shortlongterm drawbacks from detrimental interventions or compromising the environment and the health of the curators in response to this need and in line with the green deal objectives i will develop a novel cuttingedge user and environmentalfriendly cyanobacteriabased consolidation technology cyatech to restore and preserve monumental and ornamental calcareous stones in a sustainable waythus i will i establish an effective formulation for the cyanobased consolidation technology ii set up ondemand and precision bioconsolidation through the use of different artificial light sources and the prediction of the genemetabolite network in response to these physical switches iii prove the performance of the novel cyanobased technology insitu comparing it with the most advanced bioconsolidation strategy available so far cyatech will achieve sustainable management of stone heritage sh an essential component to culturerelated economic activities sociopolitical development urban sustainability education and environmental protectionthe msca fellowship will jumpstart my career in the biotech sector applied to the conservation of sh it will enrich my professional profile with i critical knowledge in cultural heritage ch microbiology by combining an indepth understanding of the stone ecosystem with material analyses and diagnostic tools to identify green conservation strategies ii communication and management skills that transcend benchtop expertise and technical proficiency iii increased employability and visibility as a female scientist fostering my selfempowerment as well as the empowerment of women in science and vi a shift to translational research developing biotechnologies that would impact the environment and the society in agreement with the green deal and the new eurupean bauhaus initiative
grounding through the lens of backchannels in signed conversation crosslinguistic insights

1 in 1000 deaf or hardofhearing individuals in the eu communicates in one of 31 national or regional signed languages sls as their first language understanding how deaf signers of different sls coordinate their interaction to build and maintain mutual understanding known as grounding is thus a key issue in unveiling the highly cooperative nature of human communication however research on the interactional infrastructure of sls is still understudied combining insights from comparative linguistics computational and conversational analysis signback describes how deaf signers from two unrelated sls namely norwegian sl nts and french belgian sl lsfb achieve mutual understanding in conversation to achieve this i will analyse one core mechanism recognised for providing positive evidence of understanding in interaction namely backchannels this project will be the first crosslinguistic study to adopt a synchronic corpusbased approach to sls by combining quantitative statistical processing with a qualitative interactional view on language to achieve a better understanding of human interaction in context the integration of these methods across sls will provide key insights into the interactional practices of two linguistic minorities thereby further contributing to a more dynamic and semiotically diverse view of language signback will make a major contribution to the field of sl linguistics by further documenting two under described sls it will provide vital implications to a range of domains including i curriculum design for sl interpreters ii effective development of slbased humancomputer interaction and iii baselines for clinical research investigating impaired social functioning the innovation of this project therefore lies not only in its object of study which includes an overlooked side of linguistics but also in its crosslinguistic scope by being more socially inclusive towards two endangered linguistic minorities
bridging disciplines unraveling the morphological alterations in the shoot apical meristem during flowering

the life cycle of flowering plants includes a major developmental change known as floral transition which occurs in response to endogenous signals or environmental variables 1 during this transition the shoot apical meristem sam which contains a stemcell niche transitions from a vegetative meristem that generates leaves to an inflorescence meristem that initiates flowers this identity change is accompanied by substantial morphological alterations which transform the sam from a small flat structure to a larger domed one 2 increasing sam size at floral transition is proposed to allow more properly spaced flowers to be formed in the inflorescence but the mechanisms underlying sam doming remain poorly understoodi hypothesize that sam doming results from an extensive internal reorganization to test this i will characterize sam morphology at the tissue and singlecell levels from confocal images of the sam throughout floral transition this analysis will provide a timeresolved morphological characterization of the internal organization this will be complemented by an examination of reporter gene expression domains within the meristem the studied genes will include wuschel and clavata3 which maintain the stemcell niche and genes related to floral transition such as apetala2 which contributes to doming subsequently i will develop a multicellular model of the sam during floral transition and of the expression domains of those genes and investigate their relationship with tissue organization and the doming process this study will provide an unprecedented quantitative characterization of the internal organization of the sam and will elucidate how tissue internal reorganization affects morphogenesis
electrothermal spatial light modulator for neuronal tissue imaging in depth

in the current era of images spatial light modulators slm are essential building blocks to improve the performance of new photonic devices all the way from the consumer market with displays and cameras to the research and clinic environments with advanced microscopy however spatiallight modulation that is capable of generating submillisecond phaseshifts without artifacts and polarization dependence is challenging the etslm neurons project leverages on a concept based on an electrothermooptical effect recently introduced by the host laboratory institut de la vision paris in collaboration with the quidant lab eth zurich and on a set of innovative knowhows of temporal pulseshaping and thermal properties engineering developed by the fellow the proposed approach relies on the temperature dependence of the refractive index of materials physical effect involved in mirages by engineering the temperature landscape in a thermooptical material one forms a distribution of refractive index associated with a desired optical function like a lens or a more complex freeform element nat photonics 2019 however this concept coined as smartlens is still in its infancy with limitations in terms of response time and heat confinement those problems have been recently overcome by the fellow nat communication 2021 taking advantage of the transient heat state and using heat sink the project aims at combining these innovations by first developing a tunable multiplane focusing and imaging system for microscopy and applying it to monitor neuronal activities in 3d its validation will pave the way to developing an electrothermal et slm featuring a sub s response time such performances would particularly improve the domain of wavefront shaping to image through dynamic scattering media such as invivo brain cells in this context we aim to combine the use of the etslm with advanced microscopy systems to perform indepth live neuronal imaging
machine learning the microbiome for identification of novel antimicrobial peptides

abuse and overuse of antibiotics has led to antimicrobial resistance amr which is a major global health concern in the eu there are around 30000 amrrelated deaths per year and the incidence of amr is on the rise experts have predicted a loss of 10 million lives by 2050 one of the reasons to find alternatives to tackle this grave and complicated health challenge is that only very few antibiotics are discovered and those in the pipeline do not have the ability to circumvent amr development in microbes thus there is a need for discovery of novel antimicrobial agents that can take the place of conventional antibiotics in comparison to conventional antibiotics antimicrobial peptides amps especially bacteriocins are effective in rapidly eradicating microbes thereby reducing amrrelated issues hence the proposed project aims to identify ideal amps that can eradicate pathogens and reduce the emergence of amr the approach will be to mine the sequences of the most dominant commensal genomes to identify suitable candidate amps the identified amps will be stored in an online catalogue which can be leveraged by researchers working in the same field furthermore the antipathogenic ability of the selected amps will be confirmed through invitro techniques followed by studying their amr developing propensity additionally genes leading to amr will be identified and knocked out to study the effect on amr furthermore the synergistic activity of the identified amps along with antibiotics will also be studied these objectives will be achieved by using advanced computational and machine learning techniques followed by invitro techniques the project will lead to discovery of amps with least amr developing propensity and will also provide information about putative amps that can be developed along with toscana life sciences tls foundation industrial placement to explore their therapeutic potential
fluorinated lipid nanoparticles for gene delivery and diagnostics

the formulation of drug nanocarriers has attracted increasing attention over the last decades in particular the possibility to combinetherapeutic and imaging functionalities in a single nanoplatform theranostic has been widely explored to advance therapeuticapproaches and promote the transition from conventional medicine to personalized medicinedrug nanocarriers holding the potential to produce a revolution in medicine are lipid nanoparticles lnps for gene delivery theyhave proven versatility and efficacy even though today it is still not possible to predict and control their cellular uptake and targeteddelivery one of the main unmet challenges of lnp formulations is increasing their cellular uptake and gene release into the cytosolcurrently it is possible to follow the fate of lnps after administration only with the addition of labels eg fluorophore or specificribonucleic acid rna sequence encoding for fluorescent protein this results in the lack of possibility to follow the fate of lnps onceadministered in vivo with a noninvasive imaging technique theranostic strategies to deliver rna and simultaneous imaging oftarget organs is an important unmet goalrecently it has been demonstrated that fluorination of components in gene delivery vehicles strongly improved their cellular uptakeand most importantly their gene endosomal escape the fluorination strategies investigated so far use either cf3 groups or longlinear perfluoroalkyl chains but a tailored design of the fluorinated group could also endow the nanocarrier with excellent imagingfunctions in this context fluoneed strategy is to tailor fluorination of lnps in order to i improve their therapeutic efficacy byenhancing lnp cellular uptake and promoting gene endosomal escape ii render lnps trackable in vivo by 19fmri and in vitroex vivo by raman microscopy
antiviral antibacterial antifungal nanocoating platform

the nanobloc consortium of 4 leading universities institutes and 5 companies 3 smes 2 large enterprises will develop upscale from trl3 to trl6 new alleuropean antimicrobial antifungal antiviral coatings made by industrially scalable green technology suitable for application on a variety of substrates porous filter materials air filtration units face masks textiles protective clothing mattress covers aprons wallpaper on a variety of hightraffic solid surfaces door knobs handles handrails sanitarywaretaps etc a research line will focus on thin coatings 200 nanometers deposited by physical vapour deposition formed by a glass andor ceramic matrix eg silica capable of incorporating silver or other metal nanoparticles which can be applied on countless substrates these coatings allow a gradual release of ions without dispersing the nanoparticles in the surrounding environment have demonstrated their effectiveness toward proliferation of bacteria fungi viruses including respiratory syncytial virus influenza virus a with demonstrated virucidal effect towards sarscov2 on face masks they can withstand temperatures up to 450 degrees celsius without altering their antimicrobial properties thereby suited for thermal regenerationin addition the project will build on previous work in obtaining coatings effective against a range of pathogens using technologies such as uv cured lacquers solgel and electrophoretic deposition a key strength in our approach is in merging these research lines to obtain innovative products that will be brought to market by our industry participantsnew knowledge generated in the project on antiviral mechanisms coating durability in operating conditions will be used to select the most suitable technology for each application to develop and upscale effective durable biocidalvirucidal coatings to relevant demonstrators with no toxic effects for health environment
eupraxia doctoral network

eupraxia is the first european project that develops a dedicated particle accelerator research infrastructure based on novel plasma acceleration concepts and laser technology it focuses on the development of electron accelerators and underlying technologies their user communities and the exploitation of existing accelerator infrastructures in europe it was accepted onto the esfri roadmap for strategically important research infrastructures in june 2021 as a european priorityto fully exploit the potential of this breakthrough facility advances are urgently required in plasma and laser rd studies into facility design and optimization along a coordinated push for novel applications eupraxiadn is a new msca doctoral network for a cohort of 10 fellows between universities research centers and industry that will carry out an interdisciplinary and crosssector plasma accelerator research and training program for this new research infrastructure the network focuses on scientific and technical innovations and on boosting the career prospects of its fellows
enlightened demonstration of integrated rolltoroll assembly of light energy harvester and flexible hybrid electronics to produce iot devices

currently most internet of things iot devices and low power consumer electronics devices are powered by primary nonrechargeable batteries which require periodic replacement and maintenance owing to their relatively short lifespans as power sources considering the advancement of iot ecosystems for smart homes offices factories and retail by 2027 an estimated 30 billion iot devices will be in use powering a huge number of iot devices solely from primary batteries would not be practically sustainable from an environmental resource safety and cost perspectiveenergy harvesting technology has the potential to overcome these issues through providing selfsufficient autonomous lowpower for iot electronics by harvesting available unused energy a promising energy harvesting technology is through light energy harvesting leh of ambient indoor light using photovoltaic technology which is capable of generating power even under indoor lowlight conditionswithin this class of photovoltaic devices are organic photovoltaics opv which unlike inorganic silicon have various inherent advantages such as lightweight flexibility solution processability and costeffective large area manufacturing capabilities moreover opvs can convert weak indoor light into electricity more efficiently than other pv technologies due to their spectral tunability and higher optical absorptivity as well as low leakage currents which are desirable for efficient operation of pv cells as they minimise power losses and improve the fill factor especially at lowlight intensitiesthe main focus of the enlightened project is to increase the potential of pv technology for lowpower lowlight applications by demonstrating the viability and potential of opvbased leh technology to meet the power and energy requirements of a diverse range of customers representing retail property tech and consumer electronics
european bus rapid transit of 2030 electrified automated connected

the ebrt2030 project will create a new generation of advanced full electric urban and periurban european bus rapid transit brt enhanced with novel automation and connectivity functionalities to support sustainable urban transport by reducing costkmpassenger tco ghg and pollutant emissions and traffic congestion the ebrt2030 project is developed through three main lines 1 the development of technologyfocused key innovative solutions for brt both at system and subsystem level at level of vehicle infrastructure operation and iot connectivity 2 7 demos of brt system innovative solutions in realoperation both cityoperatorled and brt systemfocused or focused on specific technology innovation at subsystem level that are ready for brt operations in europe and outside europe in latin america and eastafrica and fully integrated in the whole urban mobility scenario 3 the definition a new european concept of bus rapid transit for year 2030 benefitting of evaluation multiplication and replication of the realoperation test of innovations that improve the performance of the whole european urban bus systemall cities in ebrt2030 have brt lines already in operation or launched within 2023 and strongly committed to innovate with electrification automation connectivity technology tailored to the characteristics of european bus operations
old and young star clusters tracing evolution and assembly

in the standard framework of galaxy evolution galaxies form in a twophase scenario that comprises a quasimonolithic formation of an insitu population followed by the accretion of of lowermass galaxies as these merger processes significantly alter the morphology and kinematic state of a galaxy reconstructing the assembly history of galaxies is a challenging but fundamental task to understand galaxy evolution in that context dense star clusters such as globular clusters young massive clusters and nuclear star clusters that still contain information of their birthplace and subsequent evolution imprinted in their stellar population are potentially powerful tracers of galaxy assembly while ancient globular clusters are fossil records of early star formation and galaxy accretion young massive star clusters trace recent star formation episodes and interactions and nuclear star clusters provide an unique window into the evolution of a galaxys central region the odyssey action aims to fully unlock the potential of these star clusters as tracers of galaxy evolution by employing a comprehensive framework that combines for the first time the insights provided by globular clusters young massive clusters and nuclear clusters to achieve this odyssey has two main objectives 1 exploring the complex interplay between galaxies and the star clusters they host and b constructing a flexible semianalytical model that constrains the assembly history of individual galaxies from their star clusters the proposed research programme will greatly advance our understanding of the mechanisms that shape star clusters and of how they are connected to the evolution of their host galaxies while at the same time providing a new methodology of how galaxy evolution can be studied