Dragon09/odtu_chatbot huggingface dataset:
physical unclonable anticounterfeit tags using nanotechnology

the problem 119 billion eur worth of counterfeit and pirated goods were sold in the eu in 2022 europoleuipo counterfeiting of goods remains a challenge for our society increasingly so in a globalised world with long supply chains concurrently the market for sensitive goods such as medicine has also increased further exemplifying the need for anticounterfeit measures the who estimates 100000 children under five die annually from taking counterfeit pneumonia medication current anticounterfeit measures include tamperproof seals security numbers rfid tags colourshifting inks as well as holograms etc however current strategies to prevent counterfeiting of authentic goods are proving inadequate the lack of a simple and robust way of verifying the authenticity of a product is causing economic and human harm simply put the features in current physical authentication tags are clonablethe solution we propose first steps towards the commercialization of nanotechnologybased unclonable physical tags which can be attached to product packaging and authenticated via a 3dprinted portable microscope this will result in cheap reliable and foolproof encryption and cheap reliable and foolproof decryption our work having advanced in the past years from a visionary idea to a prototype offers an anticounterfeit packaging solution and can become a part of the supply chain logistics in industries from pharmaceuticals to luxury goods and even for currency
linking time encoded in neural stem cells to neuronal networks through development and evolution

several neurodevelopmental disorders such as autism spectrum disorder and schizophrenia have their roots in aberrant circuit formation hence understanding the principles underlying neuronal connectivity bears fundamental implications for the treatment of these diseases however these principles are not well understood partly due to the lack of information about how developmental processes affect connectivity while previous research has primarily relied on the study of wiring genes it has become increasingly clear that expression of these alone cannot explain circuit formation and hence developmental time ie when neurons are born is likely to play an important role to address the role of developmental time in circuit formation i will perform the first comprehensive study of how birth date relates to connectivity in an entire neuronal structure to do so i will use the genetically accessible drosophila visual system and study how neurons generated at the same time from two different progenitor regions connect to each other during development i will use cuttingedge singlecell rna sequencing of one of these regions at neurogenesis stages to determine the identity of the neurons generated and their birth order taking advantage of the existing whole fly brain connectome i will identify their synaptic partners from the other progenitor region for which the birth order is known performing precise genetic manipulations to uncouple birth date and molecular identity i will address the role of both components in correct partner matching moreover i will generate the first scrnaseq datasets of musca domestica and aedes aegypti visual systems during neurogenesis and perform circuit mapping to determine whether the mechanisms uncovered in drosophila are conserved this ambitious project will shed light into the mechanisms of circuit connectivity during development and evolution likely providing insights into the regulators that go awry in disease
knowledge graphs ai services and next generation instrumentation for research and development in social sciences and humanities

social sciences and humanities ssh provide essential knowledge to society informing our shared cultural economical and ethical decisions however ssh knowledge remains largely disconnected and poorly available impeding its full potential in research and societal applications the graphia project aims to build the first comprehensive ssh knowledge graph kg that integrates currently disconnected data into a single entry point leveraging existing infrastructure and data resources graphia aspires to significantly improve ssh data visualisation and analysis capacities pioneer advanced ai solutions tailored for ssh and develop reusable cuttingedge digital tools graphia addresses the unique opportunities posed by the qualitative diverse and contextrich data typical of ssh research where existing solutions fall short graphias innovative approach centered around the kg provides an expansive representation of ssh knowledge while leveraging ai for its enrichment access and deeper analysis including an llm4ssh graphia aims to empower researchers to uncover patterns and insights from unstructured data illuminating social phenomena and cultural trends with unprecedented clarity a key component of graphia is the ssh citation index an innovative framework for citation data extraction and enrichment across all ssh disciplines that dramatically speeds up access and understanding of previous literature on any topic graphia transcends traditional research approaches by integrating industry partners into a cohesive partnership which is pivotal to amplify the projects impact drive forward innovations that are not only academically significant but also commercially viable provide access to new markets and technologies and foster an environment of coinnovation graphia is committed to open science and increasing eu research infrastructures capabilities enhancing global competitiveness while facilitating broad and longlasting impact of project results
novel fibre value chains and ecosystem services from sustainable feedstocks

in order to stimulate the rural bioeconomy and industrial competitiveness achieve climate mitigation and biodiversity targets and increase the resilience of production systems the european union needs forerunners both in primary production and industry despite the widely recognised and urgent need to substitute fossil raw materials with renewables underdeveloped biomass processing methods and business models and poor understanding of the multiple benefits of wellplanned novel applications currently restrict the implementation of sustainable value chains with balanced environmental economic and social outcomes every step in the novel biobased fibre value chains targeted by fibsun need to be optimised from cultivation practices industrial processes and business models through to understanding the needs of consumers the use of novel industrial feedstocks must not lead to undesirable landuse changes such as the conversion of forest or land currently used for food production into land used for fibre biomass production instead the related land use must be designed to alleviate the harmful effects of desertification contamination flooding or mining by using degraded soils and marginal land to cultivate underutilised biomass feedstocks which can restore soil productivity and enhance the provision of diverse es fibsun will address these challenges using a multidisciplinary and multiactor approach involving research organisations companies and a wide range of stakeholders in a cocreational process aiming at outcomes and longterm impacts promoting green transition in the eu
new technologies to integrate plastic waste in the circular economy

nowadays only 20 of the whole plastic production is recycled due to barriers such as the presence of complex fractions in the waste streams including contaminants or multilayer materials or the mix of plastics with other types of waste that cannot be sorted in a feasible way this situation implies a high environmental impact when plastic waste is landfilled or incinerated so new solutions other than mechanical recycling must be developed to significantly increase the amount of plastics being valorized into new feedstocksplastice was conceived to solve this need by developing a set of new valorization processes that are aligned with the most relevant roadmaps of chemical recycling technologies at european level therefore main efforts will be devoted to the design development and demonstration under real conditions together with eu waste managers of four valorization technologies i mwassisted pyrolysis ii hydrothermal liquefaction iii combined gasification and chemical posttreatment and iv cascade enzymatic hydrolysismoreover plastice overall approach will deploy innovative elements along the whole value chain with the objective of integrating green technologies for the new processes to become sustainable and closing the loop to deliver circular value chains around plastics including textiles with plastic content therefore plastice works both upstream and downstream the valorization processes integrating new sorting systems quality upgrading technologies digitalization tools and ecodesign principles together with new business models linked to each step of the circular value chainsfollowing this approach plastice will impact on the amount of landfilled plastics and ghg emissions linked to process operation and fossil fuelsbased feedstock its replication will be supported by contributing to the development of new standards and regulations and by creating a community of followers supported by plastice tools and consortium
climate action to advance healthy societies in europe

despite clear signs that the impacts of climate change are escalating the global response has been inadequate traditional scientific efforts have fallen short of providing knowledge and tools that have been broadly applied in decisionmaking and innovative approaches to knowledge translation are needed to catalyse climate action in europe to protect public health our overarching goal is to provide new knowledge data and tools on i the relationships between changes in environmental hazards caused by climate change ecosystems and human health ii the health cobenefits of climate action iii the role of health evidence in decision making and iv the societal implications of climate change for health systems this will be achieved through five specific objectives 1 to develop an integrated indicator framework and repository to track the status of healthrelevant outcomes of climate actions 2 to quantify the health cobenefits and full social and environmental costs and benefits resulting from mitigation measures outside of the health sector 3 to develop innovative surveillance and forecasting tools that facilitate effective response to environmental health hazards eg heat stress allergenic pollen caused by climate change and the design monitoring and evaluation of interventions to mitigate climate change 4 to investigate how stakeholders engage with evidence regarding the health impacts of climate change and to develop strategies and tools to facilitate engagement and 5 to provide evidence and training on the most effective strategies for climate change adaptation and mitigation for health systems with specific focus on vulnerable populations including those occupationally exposed to hazards induced by climate change catalyse is a powerful interdisciplinary consortium with a mission to further develop and communicate evidence of the health impacts of climate change and respond to the urgent need for solutionscatalyse is part of the european cluster on climate change and health name and acronym to be decided
resolving magnetic origins of the hot solar atmosphere

the outer atmosphere of the sun the corona is a unique plasma laboratory it provides key insights into fundamental universal processes such as magnetic reconnection and particle acceleration yet the very existence of the corona in itself is not well understood it is composed of million kelvin hot plasma trapped by magnetic fields and overlies the much cooler 6000 k photosphere the visible surface of the sun all sunlike stars possess such magnetically dominated hotter coronae overlying cooler photospheres how do magnetic fields regulate mass and energy transport from the cool photosphere to sustain the overlying hot corona this is a longstanding problem in astrophysics which lacks a comprehensive explanation despite proposals of different coronal heating models over the past five decades the progress is hampered due to the lack of a solid observationally validated framework of how the corona is magnetically coupled to the photosphere we propose a holistic strategy to tackle this challenging problem of developing a framework for coronal heating by probing the elusive photospherecorona connection and comprehensively testing the importance of different magnetic processes in the heating of the outer solar atmosphere through this strategy we will identify key magnetic processes in the cool photosphere that regulate the hot atmosphere project origin will achieve this timely goal by exploiting unique multiwavelength observations from the recently launched solar orbiter mission in combination with realistic radiation magnetohydrodynamic mhd simulations and thus gain groundbreaking new insights into the magnetic origins of the hot solar atmosphere
using biotechnology to create the next generation of sustainable foods from the roots of mushrooms

mushlabs is a biotech company that produces meat replacement from mushroom roots called mycelium we have developed our proprietary fermentation technology to create mushroom biomass a meat replacement ingredient revolutionizing plantbased alternative proteins our mission is to change the way people eat by producing tastier healthier and more sustainable foods we take pieces of mycelium and cultivate them in a controlled and optimal environment these serve as the seed for the mushroom biomass we harvest we feed the mycelium with side streams of agroand food industries in large bioreactors the mushroom mycelial cells ferment the side streams and multiply this biological process accumulates biomass rich in protein dietary fiber and micronutrients with a savoury flavour which serves as the main raw ingredient for all of our products with very few ingredients and little food processing we create delicious healthy and sustainable everyday foods that replaces meat
bayesian inference of massive black hole binaries formation and evolution scenarios with gravitational waves

the massive black holes mbhs that we currently observe in the center of galaxies are the final stage of a complex evolutionary path in which seed bhs at high redshift grow in protogalaxies through episodes of merger and accretionif mbhs are brought sufficiently close during a galaxy collision they can merge emitting gravitational waves gws in 2034 the laser interferometer space antenna lisa will observe the gws from merging mbhbs across the entire universe providing exquisite estimates of the binary parameters as astrophysical processes such as gas accretion supernova feedback and dynamics leave an imprint on the mbhbs masses merging redshift spins and eccentricity distributions detecting mbhbs will provide us indirectly information on mbhbs formation and evolution scenariosthe scope of the project is to asses lisa ability to constrain the mbhbs astrophysical and formation mechanisms combining stateoftheart simulations to predict the mbhbs population with reverse gaussian process and hierarchical bayesian analysiswe plan to implement a semianalytic model sam to describe the complex processes shaping the mbhbs distribution and to model astrophysical processes and formation scenarios with population hyperparameters we will construct a grid in the hyperparameter space where each node will correspond to a realistic population of mbhbs these points will serve as a template bank for a gaussian process interpolator which in turn will be the backbone of a hierarchical bayesian inference framework this framework will be employed to extract the posterior distributions of the population hyperparameters with the final goal of inferring the contribution of different astrophysical processes to the mbhbs population
discovering collagen i degradation process in chronic diseases with fibrotic component

fibrosisrelated chronic diseases cds are amongst the biggest societal burdens in europe with fibrosis being recognised as the main driver of morbidity and mortality extracellular matrix ecm is a key player in fibrosis with an excessive accumulation of type i collagen col1 being a predominant component of the fibrotic tissue while the increase in col1 production is considered a main driver of fibrosis respective drugs had limited efficacy new evidence indicates that attenuation of col1 degradation is highly relevant contributing to onset and progression of fibrosis ambitious early stage researchers esrs will join forces within a multidisciplinary comprehensive and intersectoral doctorate training programme embedded in an existing network of excellent research groups across europe to investigate the outsidethebox idea on impaired col1 degradation being a key driver of fibrosis the main scientific goal is to improve the understanding of molecular mechanisms associated with col1 degradation in major fibrosisrelated cds and investigate the disruptive hypothesis of attenuated col1 degradation being the key driver of fibrosis and a major contributor to onset and progression of cds this will be achieved through multidisciplinary research and training combining stateoftheart omics approaches and data peptidomics proteomics and transcriptomics in a bioinformatics framework followed by in and exvivo investigation complemented with esrs training on translational skills and competences such a programme will train a new generation of translational researchers able to covert ideas into products and will have a profound impact on their employability and competitiveness the project will progress beyond the state of the art and provide the currently missing fundamental knowledge on the molecular pathophysiology of col1 degradation setting up the stage for novel biomarkers and antifibrotic therapies
biointelligent production sensor to measure viral activity

we aim to transform virus biomanufacturing processes and enable new quality control strategies by a continuous realtime capable biohybrid sensor technology to detect cellbased virus infection cycles biopros sensor concept makes use of an optical sensor technology in combination with cellbased measurement principles in this context a platform technology will be developed that can be adapted to multiple specific analytes which enables its applicability in different industries and production settings the development of such platform technology together with its technological complexity requires the involvement of multiple stakeholders throughout europe and across disciplines biology engineering science data science manufacturing experts digitalisation has to extend from the very beginning of the process into the whole manufacturing chain utilising all advances achieved in smart and lotsizeone manufacturing in recent years this leads to the closely intertwined interaction of technical informational and biological systems also referred to as biointelligent systems this new paradigm opens up a large new space for innovations recognised as a strategic field in america asia and europe based on the manufacturing excellence leadership of europe biopros will significantly contribute to all expected impacts of the destination digital and emerging technologies and explicitly to each of the four expected outcomes of this call topic the consortium aims to gather all required expertise and set the basis for international partnerships in close cooperation with paneuropean initiatives and with the support of an industry advisory board project partners aim to transform the vision of biointelligent manufacturing and demonstrate the applicability of disruptive technologies in an industrial setting we will promote the research community for biointelligent methods and applications worldwide and at the same time create technology sovereignty for europe
nitrecercat la nit europea de la recerca

the catalan european researchers night nitrecercat project consists in a two years proposal for 2022 and 2023 centered on two main activities the european researchers night ern and researchers at schools rs the wellknown ern will be held on september 30th 2022 and 29th 2023 during these two years eight different partners will bring research and researcher closer to more than 30000 people and 10000 a part of ern the present proposal also includes the researchers at schools rs which adds a much better and longer interaction of pupils with the research from the catalan institutions 15 schools and near 4000 students will become niteducat schools with twoyears of stable collaboration between a team of researchers and the schools primary and secondary the will focus on making the general public aware about the present missionoriented program of european commission eu mainly in the idea of how researchers can help to change the world researchers for change nitrecercat is divided in two main activities spread throughout the catalan territoryocatalan european researchers night nit europea de la recerca ern la recerca va a lescola during friday morning researchers are going to schools to show their research and vice versa la nit catalana de la recerca friday eveningnight main activity women in science based on the exhibition cientfiques catalanes 20 will be shown in all the locations and venues online esopegat amb la recerca during saturday morning research will be found in everyday locations from markets to museums malls etc oresearchers at school rs niteducat schools going beyond single dissemination activities this part of the project aims to develop 15 mediumlongterm projects that promote stable collaboration between a team of researchers and primarysecondary school researchers visiting schools during the whole year many activities will be addressed to students
paneuropean management of biological toxin incidents through standardisation initiatives for crisis response enhancement

biotoxins pose significant challenges to current crisis management approaches existing concepts of operation derived from chemical biological radiological and nuclear doctrines and union civil protection mechanism initiatives do not address the distinctive and highly complex attributes of a biotoxin crisis embrace aims to improve europes capacity to respond effectively to biotoxin incidents we will consolidate and apply scientific and clinical knowledge of biotoxins to revise response protocols and deliver innovative solutions specifically tailored to address gaps and needs identified in current provision highlights include analysis of biotoxins not previously addressed in this context riskbased recommendations for ppe and novel decontaminants in vitro studies to identify human biomarkers of exposure novel samplers portable biosensors and field diagnostics devices and software tools to assist responders in biothreat risk assessment to ensure intersectoral and crossborder interoperability of these solutions and successful commercialisation of our exploitable assets we will prioritise a carefully planned standardisation and valorisation programme embrace will engage with existing initiatives and projects to create a vibrant biotoxin knowledge network a multisectoral community of stakeholders on the basis of which a sustainable biotoxin task force will be established as a source of expertise and guidance on biotoxin incidents both for embrace and the wider community the network of stakeholders and embraces ambitious programme of scientific technological and operational advances will be supported by the creation of a biotoxin reference and stakeholder hub designed to facilitate knowledge exchange and provide users with direct access to widely distributed and expertise finally embraces innovative sustainability strategy will ensure that its solutions and the biotoxin community continue to thrive beyond the duration of the project