Dragon09/odtu_chatbot huggingface dataset:
sustainable renewable energy value chains for answering farmers needs

in order to defossilise the agricultural sector in line with the eu green deal the local incorporation of renewable energy technologies matching local farmers needs in terms of electricity heat mobility waste and land management is key in this context the value4farm project will gather 14 partners including 7 researchoriented partners 3 smes and 3 associations in a 42month project to demonstrate at trl67 the effectiveness sustainability and replicability of three renewablebased local value chains based on biogas and coupling sustainable food and renewableenergy production in denmark addons to the traditional biomethane pathway will be brought for answering the local specificities of largescale farms in belgium a pathway towards better use of alreadyexisting residual streams will be demonstrated for efficient production of electricityheat and fuel thus answering mobility needs for smallscale farms in italy hybridisation compatibilities will be investigated towards the creation of an efficient offgrid biomethane plant sustainable agricultural crop protocols will be developed based on at least 200 farmers specifications meeting the challenges of the agricultural sector while matching renewable energy production all value chains will promote circularity through nutrient recovery the uptake of the demonstrated value chains will be facilitated by a strong involvement of farmers from the very beginning of the project three replication sites in iceland italy and poland have already been selected in the project the assessment of the economic environmental and social benefits of the value4farm value chains will be widely shared and disseminated to relevant stakeholders in particular to encourage the wider farming community across europe to benefit from producing both food and energy from their land and showcasing the lessons learnt in the demonstration sites an online decision support tool will be made available in openaccess
babots the design and control of small swarming biological animal robots

we aim to establish a fundamentally new technology of biological animal robots babots consisting of small animals with a genetically modified nervous system enabling the execution of a desired repertoire of behaviors beyond their natural abilities we will implement the first babot system in c elegans a 1 mm long nematode worm these worms will be programmed to act as a collective and to detect locate and attack invading pathogens in an agricultural setting being 100 biological babots are highly compatible with the natural environment selfproducible and fully degradable they will also be agile and highly sensitive to surrounding signals to control babot behavior we will genetically insert specific new synaptic connections and synthetic gene circuits in c elegans to produce artificial aggregation dynamic sensorimotor switching and other functional building blocks to ensure a safe and controlled deployment we will genetically implement a multilayered biocontainment apparatus to gain tighter control over the babot collective behavior we will exploit heterogeneity in the population blending for example leader and follower babots based on their differential access to information the science behind this innovative technology includes a synthetic neurobiological approach to modifying individual worm behavior the study of collective behavior in engineered worms and the development of a theory of heterogeneitybased swarm control we also dedicate a substantial effort to establish a firm and effective safety ethical and regulatory framework under which current and future babots can be developed this project will generate a radically new approach to biorobotics that could contribute to precision agriculture industry and medicine improving over a previous proposal we significantly enhanced i the methodology ii the safety and ethical aspects and iii the demonstration and exploitation by implementation in an agricultural setting
secured satcombased solution enhancing emergency services and search rescue missions sat2rescue

the aim of the sat2rescue project is to strengthen the use of satellite communication by government institutions and nongovernmental organizations in particular in the areas of response to natural and manmade disasters optimization of emergency services activities and telemedicine in humanitarian aid infrastructure and services under the govsatcom initiative will be usedas part of the project a telecommunications satellite terminal will be built which it is portable and mobile compact dimensions flat electronic antenna and rugged durable form allow it to fit in a vehicle boat or carry in a backpack it allows you to establish reliable communication voice and data transmission even in the absence of a cellular network signal or outside the range of a terrestrial radio communication system it is fully automatic when turned on it locates itself using gnss including galileo locks on to a satellite in both geostationary and low earth orbit and controls the antenna to track it it can also dynamically switch between satellites without interrupting the connection enables you to establish and maintain a connection even while on the move eg while driving it is resistant to gnss signal jamming and spoofing provides the ability to divide a single satellite communication channel into independent virtual networks software defined networkingusage scenarios will be defined including mountain and sea rescue and rescue operations in urbanized areas after disasters application software will be developed for rescue operations management centers providing a situational picture of the operation integrating geoinformation and weather data image data from the copernicus system and geotag data collected via the galileo system the system will be demonstrated according to usage scenarios
restoring organ microphysiology via intravital ultracompact biopriniting endoscope

minimally invasive diagnostic and surgical tools have become a staple in modern medical routines worldwide endoscopes a few millimeters in size are inserted directly into the organ or cavities inside the body allowing for high precision and fewer traumacontaining procedures so far these minimally invasive procedures have been limited to conventional microoptical imaging and micromechanical surgical routines such as cutting and making small incisions ideally any medical intervention should be capable of recreating intact biological ultrastructure and function directly at the target site following the most relevant cytocompatible approaches this proposal seeks to implement noninvasive methods yield to obtain safeguarded integrated and improved cuttingedge additive and subtractive 3d manufacturing technologies for developing a miniaturized endoscopic device for organ structure and function intravital regeneration
expand flow accessing new chemical space via a combined flash and photochemical flow chemistry approach for the functionalisation and ring expansion of heterocycles

with everincreasing costs for the development of new drugs the call for the development of more costeffective and efficient methodologies to streamline the access to new drug candidates is imperative to access new chemical space the ringdistortion strategy latestage modification of rings to a variety of different functionalized cyclic and acyclic motifs has proven a particularly successful approach recently numerous ringexpansion and functionalisation protocols to cyclopentanones tetralones functionalized butanones from cyclobutanols have been developed using classical batch processes despite the advances the translation to pharmaceutically relevant applications is still outstanding mainly due to three factors1the application of heterocycles in these protocols has been very limited or even impossible 2the twocarbon ring expansion has only been successful on arylsubstituted analogues yet not on alkenesubstituted analogues 3scaleup to practical quantities is often difficult due to the requirement for conditions difficult to realise using batch processing expand flow presents a multidisciplinary project that lies in the intersection of flash chemistry and synthetic photocatalysis with microfluidic engineering and computational chemistry for the development of a selective sustainable and applicable methodology for the ring deconstruction and functionalisation of heterocycles ultimately its applicability to the pharmaceutical industry will be proven by the total synthesis of thc and its hitherto unexplored heterocyclic analoguesoverall this project will add a valuable tool to the synthetic chemists repertoire for the rapid environmentallyfriendly and costeffective development of new drug candidates by the versatile functionalisation of various heterocycles this innovative approach will have a high scientific technological and societal impact reinforcing the european competitiveness in the development of lifesaving drugs
blocking baff signaling to treat proliferative kidney disease pkd in trout

pkdcontrol is aimed at validating the use of a recombinant protein to reduce the pathology and mortality produced by proliferative kidney disease pkd in salmonids pkd is caused by the myxozoan parasite tetracapsuloides bryosalmonae that affects both cultured and wild salmonids in north america and europe it can eventually lead to mortalities of up to 90 generating great economic loses every year to the aquaculture industry this problem may be aggravated by global warming since the incidence and severity of pkd are exacerbated by rising temperaturesduring my erc consolidator grant we have demonstrated that the cytokine baff b cell activating factor mediates the dysregulation of diverse b cell subsets present in the kidney during pkd we have shown that the intramuscular injection of a plasmid coding for the extracellular domain of baff receptor baffr led to secretion of this truncated baffr tbaffr that in turn sequestered circulating baff blocking baff signalling preliminary field tests in spain and usa demonstrated the potential of this approach in reducing the pathology and mortality of the infected stocks in this project we will recombinantly produce tbaffr in yeast to facilitate its uptake by the industry and test its bioactivity in both lab and field experiments in parallel to these technical activities we will reinforce the ipr position based on a pct international patent application that has received a very positive patentability report by the patent office we will also design a longterm ipr strategy and develop a knowledge transfer strategy through the recently initiated collaboration with a fish health management company willing to reach commercialization of tbaffr under a license and to contribute with their own funds to the activities carried out under this project a business case will also be elaborated to support the commercialization of the recombinant tbaffr to ensure that the innovation potential of our results
failoperational safety making autonomous vehicles a reality

we have seen a revolution in autonomous driving technology today more than 75 of newly registered vehicles have some level of driver assistance however despite vast strides in new ai and sensing technology fully autonomous vehicles are yet to be realized because the actuator technology for the safetycritical steering and braking systems are not mature enough to guarantee failoperational capabilitychassis autonomy has developed the first failoperational steerbywire system which is suitable for fully autonomous vehicles it is the final step toward fully driverless vehicles ie no steering wheel and will unlock the next wave of automotive drivingwe have completed a series of early prototyping and validation activities and we are now seeking the support of the eic to finalize our technology and go to market in two years to meet the roadmaps of the leading autonomous mobility developers
implications of genderaffirming hormone therapy for psychosocial functioning and social relationships of transgender people

transgender health is an area of increasing focus for researchers and medical practitioners across europe in part due to rapidly escalating numbers of people identifying as transgender a crucial oversight in this area is that very little research has examined how genderaffirming hormone therapy the most common form of medical intervention for transgender people shapes psychosocial functioning and ultimately social relationship experiences given the paramount importance of social relationships to health and wellbeing evidence for psychosocial effects of genderaffirming hormone therapy is vital to ensuring health equity for transgender people who suffer from alarmingly high rates of social disruption and suicide risk i draw together independent strands of research on biological effects of hormones from social neuroendocrinology and health influences of psychological and sociocultural factors from social psychology and epidemiology to propose a novel biopsychosocial model linking genderaffirming hormone therapy to psychosocial functioning in transgender people drawing upon this model i propose a programme of research involving four complementary work packages triangulating across a variety of novel and cuttingedge research methods this work will be guided by three key aims a to isolate causal pathways from a biopsychosocial model linking genderaffirming hormone therapy to psychosocial functioning b to empower transgender people to give voice to their own personal and relational experiences in the context of genderaffirming hormone therapy and c to guide policy and practice for gender identity services in line with the informed consent model directing focus to the improvement of psychosocial functioning and social relationship outcomes this interdisciplinary programme of research will sit at the forefront of genderaffirming healthcare and treatment for transgender people
isolation observation and quantification of mechanisms responsible for hydrogen embrittlement by tritium based micromechanics

hydrogen is an indispensable element in the energy transition and expected to be key for decarburization of the european society hydrogen embrittlement recognized and in focus of materials science since almost 150 years still causes catastrophic failure until today it is wellunderstood that all mechanisms of hydrogen embrittlement materialize at the scale of individual defects such as dislocations grain and phaseboundaries but we are still missing a correlative measurement of the mechanical behaviour of individual defects and the local hydrogen content which is urgently needed to assess the occurrence importance and magnitude of mechanisms playing a role during hydrogen embrittlement in aid of this tritime for the first time facilitates the isolation observation and quantification of hydrogen embrittlement mechanisms by tritium based micromechanics the mechanisms of hydrogen embrittlement will be isolated by small scale mechanical testing on samples containing only a few crystal defects the defect properties are observed and measured by in situ micromechanical experiments in the scanning electron microscope and at synchrotron beamlines simultaneously tritime will monitor the local hydrogen content by observing the decay of tritium with high spatial resolution for which a unique tool will be developed in addition post mortem analysis using atom probe tomography and secondary ion mass spectroscopy take advantage of the reduced mobility of tritium tritime will provide unprecedented insights into the local hydrogen content of newly formed slip bands mobile and immobile dislocations and fracture surfaces consequently if successful tritime will obtain a mechanismbased quantitative understanding of hede help and their interplay in doing so tritime sets the base for a mechanismbased optimization of microstructures used in distribution and storage of hydrogen and therefore is an indispensable tool towards europes hydrogen society
deciphering the role of regulatory factors driving epigenetic inheritance of alternative chromatin states

epigenetics the study of molecules and mechanisms that perpetuate alternative gene activity states in the context of the same dna sequence is an exciting field with important epistemological and biomedical implications but the molecular mechanisms underlying epigenetic inheritance are still little understood polycomb group proteins are pleiotropic chromatin components that have been suggested to be capable of driving epigenetic inheritance and their dysregulation leads to cell fate changes and is associated with cancer recently we discovered that a transient decrease in expression of a polycomb gene can drive the formation of tumors of epigenetic nature ie in the absence of dna mutations the goal of waddingtonmemory is to decipher how epigenetic components can lead to stable changes in cell fate specifically we willaim 1 identify the molecular steps leading to epigenetic cell fate derailment following transient polycomb protein depletion in drosophila we will perform a timecourse study using bulk and singlecell multiomic and imaging approaches in order to dissect the dynamics of cell fate transformationaim 2 identify the polycombtargets leading to cell fate dysregulation and decipher their mechanistic role we will test candidate factors identified in aim 1 in order to identify those that drive cell fate derailment and to elucidate their mode of actionaim 3 test the role of epigenetic inheritance in mammalian cell differentiation we will analyse the role of epigenetic inheritance in mouse gastruloids an in vitro system that reflects cell differentiation events typically found in early embryogenesistogether this groundbreaking project will reveal how epigenetic components drive cell fate derailment and it will establish robust paradigms that can be utilized by the scientific community to discriminate between epigenetic inheritance and dna sequencemediated cell transformationlli
realworld evidence for decisions in diabetes

randomised controlled trials are the cornerstone of evidencebased medicine however the digitisation of realworld data rwd including data from devices wearables and electronic health records in large national registries provides opportunities to demonstrate efficacy and safety of innovative technologies including drugs devices diagnostics and digital health these data are particularly relevant to longterm conditions such as diabetes mellitus where drugs lifestyle interventions and digital technologies often work together to better utilise rwd in diabetes for regulatory decision making a development of standards guidance and an assessment of the efficacy to effectiveness gap is neededreddie realworld evidence for decisions in diabetes aims to explore how rwd can complement rcts to improve efficacy safety and value for money of technologies to prevent and treat diabetes the overall aim of reddie is to support the use of rwd in diabetes and healthrelated research which will maximise europes scientific expertise and knowhow to benefit people with diabetes resulting in safer more efficient and costeffective interventionswe thus aim to engage with stakeholders such as regulatory and hta authorities and codevelop evidentiary standards for the collection assessment and acceptability of rwd we will then develop and validate stateofthe art modelling techniques using synthetic data derived from large national registries to better assess outcomes of interventions using rwd we will use data from four large national registries to elucidate the gap between outcomes in rcts and rwd studies and understand the factors that affect this gap finally we will test the ability of machine learning to facilitate the better use of rwdreddie will generate standards for rwd use for the evaluation of medicines and other interventions by regulatory authorities and hta bodies
superconducting radiofrequency switch for quantum technologies

despite the high expectations and numerous announcements that have been made over the past ten years the spread of quantum computers qcs is still in its infancy the major factors limiting the diffusion and market penetration of qcs are their low scalability and high cost both issues are connected to the bulkiness and complexity of the signal lines that operate the qc the required large amount of cables undermine the scalability and decrease the thermal stability of the quantum processing units qpus with this project we aim to increase the scalability and reduce the thermal issues of qpu developing a radiofrequency rf switch quest that allow to simultaneously control the state of multiple qubits through the same cable quest goes well beyond what is achieved with stateoftheart electronics that typically provide bulky slowly and energy inefficient solutions the core component of quest is an allmetallic superconducting transistorcontrolled via gate voltages this transistor exploits the peculiar characteristics of a superconducting material to work at frequencies 1 thz unachievable with classical semiconductor electronic components and with nearly zero power dissipation during spectrum we are going to build a complete test platform quest devices the stateoftheart nanofabricated prototype of quest will be tested in a custom made cryostat able to unleash the true potential of this technology furthermore ultrafast fpgabased electronics will take the case of the control of multiple switches providing an affordable and performant control over the prototype this platform will be the environment in which quest will be studied at strict contact with the state of the art quantum processing units the experiments performed in real quantum computer under the eufunded spectrum project will be the first step to the true quantum revolution
linking ketone metabolism and signaling in heart failure with preserved ejection fraction

heart failure with preserved ejection fraction hfpef is a burgeoning public health problem for which there are little to no evidencebased therapies this syndrome has proven particularly challenging because of the limited insight into its underlying molecular mechanisms metabolic adaptations are critical for cardiomyocyte response to stress ketones are metabolites actively produced in heart failure and their role as metabolic rheostat capable of modulating cardiac metabolism and cardiomyocyte signaling pathways has been postulated however there is fundamental open gap in understanding how ketones are utilized as source of energy in hfpef and how hydroxybutyrate ohb the most abundant ketone plays a role as nonenergy carrier governing cardiomyocyte function in this project proposal i hypothesize that ketones are major regulators of cardiomyocyte biology representing an alternative source of fuel in hfpef energy role and act as protein modifiers trough hydroxybutyrylation a lysinebased posttranslational modification ptm thereby regulating chromatin architecture gene transcription and metabolic signaling in cardiomyocytes nonenergy role the overall aim of ketocardio is to define mechanisms integrating ketone metabolic adaptation with signaling pathways and epigenetic changes in hfpefstressed cardiomyocyte coupling proteomics transcriptomics and genomics approaches together with cardiac and systemic metabolic evaluation and rigorous preclinical experimental modeling of hfpef i will be able to define the previously unrecognized roles of ketones as energy substrates in hfpef and as substrate for proteins ptm impacting on cardiomyocyte function in summary focusing on metabolic pathways that govern cardiomyocyte abnormalities in preclinical hfpef this project will provide a transformative molecular understanding of ketones biology in cardiomyocyte fostering innovation in the field and beyond