Dragon09/odtu_chatbot huggingface dataset:
my first body bodilyself representation in normal and pathological developmental context

the representation of ones own body as a distinct entity from the environment ie bodilyself representation bsr is a fundamental component of our sense of self neuropsychological literature has provided an important contribution revealing that brain damage can selectively disrupt bsr myfirstbody starts from my wellgrounded expertise in bsr pathological alterations and aims at providing the first comprehensive account of the ontogenetic development of bsr by translating from a neuropsychological to a developmental perspective first i will look for implicit signatures of the bsr emergence in prenatal and postnatal life by describing the maturation of the crucial components identified through the study of neurological patients wp1 then i will move to a causative level by challenging i the neural mechanism that underpins the bsr emergence wp2 and b the developmental context that leads to its normal and pathological growth wp3 i expect to describe a clear picture of bsr development wp1 and its underlying network dynamics wp2 starting with a primitive coding of the bodilyself in space which likely emerges in the maternal womb and proceeding to further specializations along postnatal life until the maturation of a more abstract knowledge of the bodilyself from the comparison between congenital and acquired motor deprivations wp3 i expect to provide the proof that early motor experience represents the crucial context for bsr development myfirstbody pioneers a new area of research at the intersection between neuropsychological and developmental research by addressing different levels of analysis cognitive and neural in foetuses infants and clinical populations all while combining advanced neuroimaging techniques foetal fmri eeg fnirs the final outcome will result in original theoretical insights innovative methods and translational impacts that will represent the optimal foundation for future investigation in the field
understanding the processes underlying societal threats using novel clusterbased methods

social scientists are eager to answer questions about relations between constructs like beliefs or values for example do values affect climate change beliefs do perceived threats predict political beliefs do risk perception and susceptibility to misinformation determine vaccine hesitancy polarized beliefs about climate politics and vaccination are a societal threat and it is important to study what drives them largescale survey data is gathered to do sousing regression to answer the questions ignores that constructs are not directly observable but measured by survey items containing measurement error challenge 1 not correcting for this causes the studied effects to be underestimated and conclusions to be misguided when many groups are involved such as many countries in the european social survey the underlying processes likely differ across groups for example drivers of climate change beliefs may differ for countries experiencing extreme weather groupspecific or multilevel analyses result in numerous groupspecific regression slopes or random effects making it hard to find which regression effects are different or similar for which groups challenge 2 across many groups the constructs measurement is often inequivalent or noninvariant for example due to translation challenge 3 a measurement model indicates how items measure a construct and disregarding noninvariance in this model invalidates the comparison of effects among constructs ie one may find differences that are actually due to noninvarianceby tackling challenges 13 the proposed mixture multigroup structural equation modelling framework provides the tools to break new ground in understanding what drives constructs like polarized beliefs a clustering finds subsets of groups with common processes flexible measurement models account for noninvariance so that the clustering focuses on the processes i will implement the methods in freely available software
inhibiting resistance to immunotherapy in oncology by targeting netrin1

immune checkpoint inhibitors icpis have recently revolutionized the treatment and management of cancer yet progress recorded and impact on longterm survival affect only a limited fraction of patients as most of the cancer patients do not or incompletely respond to icpis due to primary or secondary resistance to these treatmentsnetris pharma is an innovative biotech company based in lyon the company has developed np137 a humanized monoclonal antibody targeting netrin1 able to drive tumor growth inhibition and alleviate resistance to icpis both impacts already confirmed in preclinical models the objective of the immunonet project is to conduct a proofofefficacy clinical trial assessing the efficacy of np137 to alleviate suspected resistance to icpis the increased response rate to icpis with np137 would have a major impact on patients having limited treatment options beyond immunotherapies and create significant growth opportunities for netris
revisiting rainfall extremes with ensembles of convective objects and their continuum of interactions with the largescale environment

as climate changes weather becomes more severe this has been of longstanding concern and difficulties arise in connecting the two different ranges of scales involved hail rainshowers and strong winds result from the local dynamics of cloud updrafts while the general circulation determines the relative occurrence of convective regimes to maintain energy balance historically limitations in computing power mostly led to separate analyses of cloud dynamics and the largescale circulation the mesoscales inbetween host a rich ecosystem of weather features organized in a diversity of shapes and morphologies but overly simplified in traditional climate modelsthis scale separation leads to large uncertainties in the projection of future extremes the dynamic adjustment of weather systems to the largescale flow is unconstrained and smallscale perturbations may feed back onto the global climate statereconcile revisits how the multiscale character of extreme precipitation emerges from the interaction between storms and the largescale circulation it introduces a novel approach by focusing on the dynamics of storm populations rather than individual storm objects this paradigm of populations is borrowed from ecology and scarcely used in climate physics it allows to overcome strong biases present in operational climate models by allowing for a diversity in the represented cloud structures and an explicit twoway interaction across the continuum of scalesthe current emergence of global stormresolving models is an unprecendented opportunity to investigate this dynamic coherence across multiple scales of motion reconcile proposes a way forward at the intersection of two wcrps grand challenges weather and climate extremes and clouds circulation and climate sensitivity with strong implications for climate model evaluation
the evolution of host manipulation by bacteriophage

the idea of parasite manipulation is well known in animal behaviour with famous examples like the cordyceps zombie fungus of ants yet the most abundant and diverse parasites on earth do not target animals but rather bacteria they are the bacteriophages or phages my hypothesis is that it is in phages that we will find the most important examples of parasite manipulation examples that will help us both understand and control bacteria and their impacts i will focus on the recentlydiscovered regulatory switch rs phage which reversibly excise and reintegrate into the bacterial chromosome to shift the host between different physiological states i and others have shown that rs phages influence a wide variety of bacterial traits including sporulation biofilm formation mutation rates or bacteriocin production however we do not understand when how or why these viruses cause such large changes to bacterial behavior the goal of my project therefore is to understand how and why rs phage evolve as a new candidate model of parasite manipulation specifcally i will answer 1 when and how do rs phages alter host behavior 2 what is the molecular basis for the effects of rs phage 3 why have rs phage evoved to change bacterial behaviours and is there evidence of counter strategies in their bacterial hosts i will work with the bacterium bacillus subtilis which is strongly affected by rs phage and a model organism allowing me to employ the very latest molecular methods my goal is to demonstrate that parasite manipulation is a major factor in the ecology and evolution of bacteria whereby many bacteria are essentially puppets of their phage masters understanding how phage achieve this manipulation also has the potential for broad impacts in an era when the need to find new ways to control bacteria becomes ever greater
smart battery manufacturing research and development assistant based on augmented reality technology and powered with the artistic project computational models

the smartistic project aims at developing and demonstrating a first prototype of a smart and interactive augmented reality ar software designed to assist in the decisionmaking of battery scientists engineers and operators while they are working in electrode formulation and manufacturing in laboratories or in production lines the software will be usable from tablets and ar glasses by touch gesture and hand gesture respectively the software will blend holograms with the real world manufacturing equipment such holograms will be powered with the unique physical and machine learning ml models developed and validated experimentally in my erc cog artistic project and which can predict the impact of manufacturing parameters on the final electrode properties by interacting with the holograms and without the need of programming skills a user can in realtime create databases from herhis ongoing experiments launch computations for analysis of experimental results or request ml predictions about the impact of herhis intended formulation and manufacturing process on the electrode properties shehe can also use the software to analyze possible deviations between the experimental results and the predictions to identify more easily factors that could explain unexpected experimental results the prototype will be developed by accounting for the users needs and from the observation of work situations once developed we will perform tests and demonstrations to assess the software usability and ergonomics for its improvement while used in real situations they will be carried out in the battery manufacturing platform of our laboratory and in companies and in institutes which already manifested interest in our proof of concept the assessments will permit improving the software to ensure its wide acceptance we will also analyze the ip technology transfer and market opportunities to valorize the intended software also thanks to networking activities
the biodiversity nexus transformative change for sustainability

bionext will develop knowledge tools and guidance for mainstreaming biodiversity into policy making and provide concrete options on how to initiate accelerate and upscale biodiversity relevant transformative change in society it will deliver an innovative nexus modelling framework that will integrate scenarios and pathways in a coproduction process with stakeholders while modelling interlinkages between biodiversity water food energy transport climate and health and enabling simulation of the impacts of indirect and direct drivers on biodiversity through its database of transformative change cases bionext will involve policy and decisionmakers and allows them to explore the concept of just transformative change plausible futures and desirable naturepositive visions for europe and multiple just transition pathways will be cocreated in workshops and focus groups taking place in various cities around europe with the involvement of diverse stakeholders the bionext pathways app will be delivered as a novel decision support tool that allows users to explore transformational building blocks for formulating policies and implementation pathways for the biodiversity nexus the results will contribute to science brokerage capacity building and networking to ipbes eu policymakers and civil society
elucidating the structural origin of niremission from agdna

the interest in atomically precise metal cluster systems has grown over the last decades due to the physicochemical properties that emerge at the nanoscale compared to the bulk regime despite promising features stability often hinders their use in reallife applications since stabilization is critical dna has been proven to be a functional and versatile scaffold for luminescent silver clusters dna oligomers are intrinsically biocompatible and are able to tune the emission color and promote high photoluminescence efficienciesnearinfrared emitting dnastabilized silver nanoclusters niremitting agdnas are promising candidates for several potential applications such as bioimaging and sensing due to improved cell and tissue penetration of nir light the development of nir emissive agdnas currently needs to be improved by three main challenges extremely limited structural information only one is available absence of a rationale for designing niremitting agdnas with high luminescence yield and poor understanding ofthis project aims to address these gaps by first synthesizing and screening a wealth of niremitting agdnas and then employing stateoftheart techniques such as pair distribution function analysis and xray absorption spectroscopy to characterize the bestperforming candidates structurally establishing a structureluminescence rationale for niremitting agdnas will be the ultimate goal of the project such findings are paramount to performing electronic structure calculations and it is the needed input for machine learning algorithms to predict niremitting agdnas with tailored optical properties the results of this proposal will thus pave the way for a myriad of different applications
aneuploidy and its impact on blood development context matters

many childhood leukaemias start to develop before birth due to accumulation of mutations during foetal development children with trisomy of chromosome 21 ts21 also known as downs syndrome ds have a 500fold increased chance of developing acute megakaryoblastic leukaemia it is well known that aneuploidy an abnormal number of chromosomes is often associated with leukaemia and is likely to be driving this increased incidence of blood malignancies in children with ds however the mechanisms that control differentiation of haematopoietic stem and progenitor cells hspcs and patterns of mutation acquisition in these cells during early human development are not well understood this study will provide novel insights into two important questions i what is the impact of aneuploidy on blood formation in the context of specific tissue and ii how it affects mutation accumulation and clonal selection in hspcs here i aim to reveal cellular and mutational processes active during human ts21 foetal blood development by 1 performing comprehensive singlecell transcriptomics and spatial transcriptomics analysis of human ts21 and healthy foetal liver and bone marrow combined with singlecell in vitro differentiation assays and 2 generating a catalogue of all somaticallyacquired mutations in hundreds of ts21 foetal haematopoietic progenitors using whole genome sequencing the approach i propose derives its power from the close integration of stateoftheart experimental data generation and computational analysis using novel methods by examining cell intrinsic vs extrinsic processes in ts21 haematopoiesis as well as mutation accumulation in individual stem cells this study will provide unprecedented insight into the mechanisms by which cellular changes induced by aneuploidy affect and possibly drive leukaemia a better understanding of early events in human development in health and disease will open new routes for diagnosing monitoring and treating disease
upstream synergies to overcome lockedin effects in widening regions and broaden internationalization pathways for sustainable innovation and competitive grant applications

milestone will attempt to establish strong collaboration links among three widening academic institutes from greece upat slovenia nic and czech republic mu as well as with an advanced partner amu fr to overcome lockedin institutional effects build synergies and create a pathway to excellence producing new knowledge in antiviral research and pandemic preparedness upat nic and mu all acknowledged nationalregional research actors funded by erdf share common interests in biosciences and will collaborate with a worldclass expert in biochemistry virology and infrastructure management the amuthe milestone strategy seeks to internationalise widening partners to boost their access to eu ri consortia in joint applications under pillars i ii as well as to unlock reinforce and improve the utilization of existing ri capacity a key project module is training knowledge sharing and the acquisition of transferable skills for ri personnel to increase performance in research research management fundraising and communicationmilestones implementation is based on welldesigned wps with specific tasks and roles for each partner to have a large impact at the scientific societal and economictechnological levels and to increase the competitiveness and reputation of all partners in the direction of future sustainable developmentfurthermore milestone is guided by the principles of gender equality open research and data management project progress will be communicated to all prospective stakeholders as well as the public through ecommunication channels and live eventsoverall milestone aims to establish an effective collaborative network among participating partners to achieve synergies between horizon europe and cohesion policy programmes erdf interreg to allow widening partners to catch up in their ri performance and to reduce the innovation gap among eu regions
metamaterials for vibration and sound reduction

metavision aims to reconcile two conflicting trends on the one hand people become increasingly aware of the negative health impact of excessive noise and vibration exposure on the other hand every kilogram of mass removed from the logistics chain has a direct economic and ecological benefit current noise and vibration solutions still require too much mass or volume to be practically feasible particularly for lower frequencies there is thus a strong need for low mass compact material solutions with excellent noise and vibration characteristics for which recently emerged socalled metamaterials mm have shown immense potential the goal of metavision is to provide highquality training on these innovative solutions to a new generation of high achieving doctoral candidates and to provide them with the scientific and transferable skills needed for successful careers in this key area which brings together scientific technological and societal challenges this will be achieved by combining a research programme which aims to i develop novel design and analysis methods in view of broadening the performance and applicability of mm ii revolutionize the manufacturing of mm towards largescale and versatile solutions and iii advance academically proven mm concepts towards industrially relevant applications with an interdisciplinary training programme composed of scientific and transferable skill courses and intersectoral and international secondments both programmes are brought together in unique industrial demonstrator projects metavision gathers universities research institutes and small and largescale industry from manufacturing construction transportation and machine design sectors with the relevant expertise to create the coordinated research environment needed to bring mm from academic concepts to largescale manufacturable and industrially applicable noise and vibration solutions paving the way towards a quieter and greener europe
ultrasoft microrobots for tumour penetration

softinvaders aims at advancing the technology readiness of the microrobots prototypes developed in the ercfunded project celloids paving the way to their future clinical translation in celloids we have developed the first ultrasoft microrobots and observed that they can move through gaps narrower than their size under magnetic actuation the microrobots have a celllike body consisting of a giant unilamellar vesicle an aqueous liquid interior enclosed by a nanometresthin membrane made of a phospholipid bilayer this allows them to deform substantially and even form thin protrusions squeezing through narrow gaps and between obstacles such ultrasoft microrobots have the potential to traverse body tissues mimicking the interstitial migration of leukocytes softinvaders will challenge our microrobots with the daunting task of penetrating a solid tumour this could open new opportunities for administering anticancer therapeutics in situ the translation from research towards innovation will be achieved by addressing three main objectives i enhancing the capabilities and magnetic actuation of our microrobots to make them suited to tumour infiltration ii developing realistic invitro tumour models for the validation of microrobots iii establishing a research collaboration with a clinical partner to guide the design of anticancer ultrasoft microrobots and define an innovation strategy if successful softinvaders will provide a preliminary validation of tumour infiltration by synthetic magnetic microrobots this will represent the first innovation step towards the realisation of microrobotsenabled insitu administration of anticancer therapies potentially leading to improved therapeutic outcomes and better life quality for millions of patients worldwide
ultrafast molecular chirality twisting light to twist electrons on ultrafast time scale

chiral molecules are characterized by specific stereo arrangements of their nuclei underlying their key function in chemistry and biology yet little is known about chiral molecular interactions at the level of electrons occurring on the ultrafast time scale developing extremely efficient enantiosensitive ultrafast alloptical approaches to track electronic dynamics is an important unsolved challenge we aim to address it in ulisses a multidisciplinary project at the interface of physical chemistry strongfield physics ultrafast and nonlinear opticswe plan to take advantage of the chiral electron currents which arise naturally in chiral molecules interacting with sufficiently intense ultrafast light the chiral nature of these currents is dictated by the molecule itself we will structure laser polarization in space and time endowing light with local chiral and global topological properties to control these electron currents enabling new orders of magnitude more efficient enantiosensitive alloptical effects gaining access to the ultrafast electron dynamics and physical mechanisms underlying the chiral function we will also develop a framework for describing geometrical magnetism generated by the electron currents in chiral molecules and introduce a new class of enantiosensitive phenomena enabled by these geometric conceptswe aim to establish 1 novel highly efficient alloptical ways of enantiodiscrimination 2 enantioresolved movies of chiral electronic dynamics 3 chiral topological light a new tool for chiral interactions and 4 bridges between lightdriven electron dynamics in chiral gases and topological effects in solids ulisses will dramatically expand fundamental understanding of the dynamical response of chiral systems to light and lay the foundation for innovative applications of alloptical methods to chiral discrimination in lowdensity samples with extraordinary sensitivity and molecular specificity