Dragon09/odtu_chatbot huggingface dataset:
understanding individual heterogeneity in ageing from stochastic dynamics of sigma factor regulatory network in bacteria

ageing is controlled at the molecular level via genetic and metabolic pathways ageing rates and patterns vary substantially even with fixed genetics and environment however molecular mechanisms of ageing generating individual heterogeneity are poorly understood stochastic dynamics of gene expression can be a main source of the variation in cellular damage dynamics leading to individual heterogeneity in ageing the sigma factor regulatory networks constitute the core part of the bacterial gene expression networks and therefore play important role in deciding the fate of bacterial cells in this project i focus on exploring the role and interplays of four major sigma factors rpod rpos rpoh rpon in individual e coli cells i plan to 1 obtain these sigma factors expression dynamics and the demographic fates at individual e coli cells in microfluidic platforms under fluorescent microscope 2 process and analyze big image data in an automated manner 3 develop mathematical models to interpret expression and demographic signals for damage and ageing i will combine the knowledge and methods from the disciplines of molecular biology genetics fluorescent microscopy and microfluidics machine learning population and evolutionary dynamics and mathematical modelling to shed light on the link from stochastic expression dynamics in sigma factor regulatory network towards individual variations observed in ageing fates
advanced power conversion technologies based on onboard ammonia cracking through novel membrane reactors

through a holistic approach apolo aims to tackle the challenges of power conversion from ammonia and develop an efficient and flexible ammonia cracking technology this technology will be coupled with fuel cells and engines to achieve complete decarbonization of the maritime sectoras the main objective of the call is to demonstrate scalability beyond 3mw the consortium will focus on showcasing the following demonstration units i a 125kw power conversion system that utilizes an ammonia cracker coupled with a pem fuel cell system achieving an overall system efficiency of 51 to 54 the ammonia cracker will be customized to work with different pressure conditions and efficiency levels of pem fuel cells a comparison of efficiency levels will be conducted to evaluate the flexibility of the cracking system for all types of pem fuel cellsii a 125kw partial ammonia cracker coupled with a 4stroke engine exhibiting an overall system efficiency above 45apolo is dedicated to minimizing the ecological footprint of transportation and energy focusing on the maritime sector to achieve this were actively developing innovative power conversion technologies such as cracker fuel cell and engine and utilizing life cycle assessment lca at various stages of product developmentthe technologies developed in apolo are capable of targeting the first 30000 ships in the market initially the focus will be on vessels with 1 to 10 mw propulsion with a significant number of them being around 3 mw in the next decade as these are the first vessels relevant for ammoniapowered solutions
our sustainable future the values that drive it and how to get there

grand and persistent socialecological challenges such as climate change push forward a rapidly growing discourse on how sustainability science can support society in dealing with todays global crises between studying change and contributing to change sustainability science seeks both to analytically understand sustainability problems but also to design interventions that can contribute solutionoptions to these problems however knowledge about how to intervene in order to reach a desirable vision ie transformation knowledge is typically missing especially how to deliberately engage with values as places of intervention leverage points as proposed by the intergovernmental sciencepolicy platform on biodiversity and ecosystem services remains a critical knowledge gap to fill these gaps lever aims to critically develop and apply a transformative theory and practice to support the coproduction of transformation knowledge including a focus on transformation knowledge necessary to investigate and unleash values as leverage points for sustainability transformation to this end lever originally combines transdisciplinary research with the empirically rigorous methods of social science experiments the scientific breakthrough consists in delivering an integrated theory of transformative research capable of representing the many coevolving links between its design principles philosophy of science normative assumptions and ethical dimensions methodologically lever opens new avenues on how to produce transformation knowledge by experimenting with testing and evaluating novel transformative methods finally lever seeks to answer the globally relevant and timely question of how to unleash values using a treatment and control group experimental design lever assesses the impact of valuestargeting interventions and demonstrates the potential of values as leverage points lever pioneers a salient conscious sciencesociety relationship in europe
global change impacts on cyanobacterial bloom toxicity

harmful cyanobacterial blooms produce toxins that are a major threat to water quality and human health blooms increase with eutrophication and are expected to be amplified by climate change yet we lack a mechanistic understanding on the toxicity of blooms and their response to the complex interplay of multiple global change factors bloom toxicity is determined by a combination of mechanisms acting at different ecological scales ranging from cyanobacterial biomass accumulation in the ecosystem to the dominance of toxic species in the community contribution of toxic genotypes in the population and the amounts of toxins in cells i will develop a fundamental understanding of bloom toxicity by revealing the combined effects of nutrients elevated pco2 and warming at each scale and integrate these responses using a unique combination of ecological theory technological advances and methodological innovations specifically i will use first principles to scale from cellular traits like carbon and nutrient acquisition cellular toxin synthesis and growth rates to population and community dynamics to enable rapid assessment of numerous cyanobacterial traits i will setup a highthroughput flowcytometry pipeline also i will develop a novel labonachip experimental platform to allow massive parallel screening of key competitive traits in various phytoplankton species and cyanobacterial genotypes to scale from these cellular traits to population and community interactions i will study genotype selection and interspecific resource competition in stateoftheart chemostats i will further scaleup to natural communities in the field and in largescale indoor mesocosms to assess global change impacts on the mechanisms underlying toxicity of near reallife blooms with this unique combination of scaling approaches i will provide a breakthrough in our mechanistic understanding on the toxicity of cyanobacterial blooms and their response to global change
economic manufacturing process of recyclable composite materials for durable hydrogen storage

ecohydro aims to develop a new energy efficient filament winding process of hydrogen storage tanks using recyclable materials we will improve the thermoplastic acrylic resin for insitu polymerization which has been used for wind energy and marine applications so far for the highspeed filament winding process by optimizing the uv polymerization of the resin and developing new filament winding tools and equipment especially we will develop multifunctional resin with fireresistance thermal insulation and selfhealing capacity which are expected to enhance the safety of hydrogen storage and hybrid tows to reduce microcracking we will develop a recycling technology to recover 100 of carbon fibres and resin from hydrogen tanks after their endoflife these recovered materials will be used for the rewinding process for new tanks manufacturing this recycling and rewinding technology will contribute to significant reduction of the cost and of carbon footprint of hydrogen storage tanks to improve the safety and durability of hydrogen tanks a new structural health monitoring technology via sensor integration into the tanks in service life will be developed in combination with data science using ai algorithm these sensors embedded into the tank during the manufacturing process will be used to monitor the soundness of filament winding process in real time to improve the yield ratio the developed technologies will be validated by four different types of industrial demonstrators trl4 using either compressed gas hydrogen storage cryogenic liquid hydrogen storage such as aboveground station tube trailor truck and bus and aviation the industrial partners of ecohydro tier 1 endusers will validate the demonstrator development and prepare a future plan for a higher trl 48 development in terms of the kpis dissemination and communication activities will be performed in relation with other eu projects as well as general public and scientific community
cryamabe problem khler metrics and kstability

one of the main questions in differential geometry is the existence of special metrics that is a way to measure distances on smooth manifolds they are the basic objects in differential geometry and can be thought of as geometric objects that can be locally approximated by the usual flat space the goal of cryamkmetkstab is to investigate the existence of these special metrics on complex manifolds from the point of view of complex differential geometry by employing techniques that come from differential geometry algebraic geometry and geometric analysis more precisely we propose a novel way to approach constant scalar curvature khler metrics by drawing a connection between the socalled cryamabe problem and kstability of the manifold
elucidating the functionspecific response of marine phytoplankton to climate change in the southwestern atlantic ocean and its influence on regional co2 fluxes an aibased approach

phytoplankton is the base of the trophic marine ecosystem and a main regulator of global co2 fluxes climaterelated shifts in the dominant phytoplankton functional types pfts their blooming periods and overall productivity are expected to have major implications on oceans carbon cycle the southern atlantic ocean sao renowned as one of the worlds most biologically productive regions and the largest carbon sink is already experiencing profound environmental changes due to climate change using aitechniques aiphytoclim seeks to analyze how climatedriven changes in physical forcings influence the functioning and structure of phytoplankton and the implications these changes have in surface ocean partial pressure pco2sw and co2 fluxes this study is founded on the analysis of a comprehensive dataset encompassing 26 years of satellite data ocean color numerical modeling results and in situ data the first goal is to establish quantitative relationships between climatedriven physical forcings in the sao and phytoplankton responses at the pft level employing neural network pattern recognition and classification algorithms 2ssom ai the second goal aims to assess the impact of the climate variabilitychange on the pfts and the influence on regional co2 fluxes the responses each pft to climate variability and interconnections between each pfts variability and the pco2sw and co2 fluxes will be explored through timeseries analysis census x13 and statistical approaches eg crosswavelets correlations knowing the coupled physicalpfts relationships over the last 26 years and using the forecasted environmental changes during the next decades cimp6 model i will assess how pfts are likely to evolve in the future ocean and the resulting implications for regional co2 fluxes the methodologies developed in aiphytoclim will provide important new insights on the oceanclimate nexus and on its influence on global climate
intelligent breast cancer diagnosis and monitoring therapeutic response training network

candoit will show how a smart multimodal multiphysic sensor array associated with dna oligonucleotides and their peptide nucleic acid pnas analogues dedicated for liquid biopsies analysis has the potential for more accurate diagnostic and treatment monitoring of bc through the study of cuttingedge technologies in bionanomaterials sensors and transducers design fluidics systems and artificial intelligence the candoit objectives are to 1 train the excellent next generation researchers for interdisciplinary careers in basic applied and especially translational bc research and with raising awareness on social issues 2 develop cuttingedge technologies for bc diagnosis and monitoring therapeutic response by bringing together eminent experts from both industry and academia including engineers computational scientists chemists physicists and clinicians 3 pursue key biological targets through intelligent methods all the way from early stage to preclinical and clinical investigation 4 in addition to respond to the bc issue the intelligent biosystems proposed will be a real technological advance breakthrough thanks to the association of different transducers to go towards a multimodal platform the association of structured nanomaterials inspired by living world and an implementation of intelligent algorithms for optimal analysis 5 build a highimpact structure ensuring multilevel dissemination and exploitation of all results
sexual conflict in the sexually cannibalistic springbok mantis miomantis caffra

sexual cannibalism which occurs when a female eats her mate before during or after mating is a classic example of sexual conflict since females gain a meal but males lose their life the risk of premature death is expected to select for cautious mating tactics that help males to secure matings and avoid being eaten although such tactics are common in cannibalistic species males of the springbok mantis miomantis caffra take a far more aggressive approach wrestling females to coerce them to mate males that win wrestling bouts are more likely to secure matings and avoid cannibalism but wrestling severely wounds females whose abdomens are punctured by males weaponised forelegs while this harmful male behaviour appears to be a classic manifestation of sexual conflict the exact causes and consequences of male coercion and female injury in this species are yet to be elucidated my project aims to use field laboratory and modelling approaches to investigate the role of sexual conflict in the evolution of cannibalistic and anticannibalistic behaviour first to determine rates of female injury in the wild i plan to use markrecapture techniques to track sexratio and injury incidence through time in wild populations of m caffra in auckland new zealand where the species is widespread second i plan to run a series of laboratory experiments to explore whether males increase their fitness by injuring females or whether injury is an incidental sideeffect of males drive to mate third i plan to run a mesocosm experiment to examine whether an increase in the intensity of sexual conflict reduces female survival and population productivitya key theoretical prediction that has rarely been tested finally i intend to use modelling techniques to investigate more generally the role that sexual conflict over mating decisions plays in shaping male and female behaviour in sexually cannibalistic taxaa relationship that is currently poorly understood
climate resilient and environmentally sustainable transport infrastructure with a focus on inland waterways

it is the key objective of the project cristal 36 months to increase the share of freight transport on inland water transport iwt by a minimum of 20 and to demonstrate on its three pilot sites italy poland and france strategies to improve reliability by 80 cristal project will assure iwt capacity at 50 even during extreme weather events towards that cristal will cocreate test and implement integrated cooperative and innovative solutions in its three pilot partners areas identified in italy france and poland the project will include the aspects of technological innovationdevelopment and digitalization further advancement towards the physical internet governance solution and business models will be proposed while targeting sustainability and infrastructure resilience requirements
does hybridization facilitate explosive speciation of lake baikal amphipods

the adaptive radiation of amphipods in lake baikal has brought forward more than 340 species 20 of the worlds freshwater amphipods making it one of the largest species flocks after the famous african cichlid radiations and one of the only large radiations in temperate climates despite this iconic status the radiation has not yet been subject to detailed genomic investigation during my phd i was able to demonstrate excessive amounts of parallel adaptation among the transcriptomes of species of this adaptive radiation in this project i will use genomic approaches to test whether the previous results could be explained by hybridisation and adaptive introgression these processes have been shown to occur in other adaptive radiations but their functional role in rapid diversification is still debated my preliminary results indicate that hybridization between two independent lineages of baikalian amphipods emerged in the period when fast speciation started furthermore i found intriguing signals of positive selection on introgressed lociadditional data and specific methodology developed in this project will enable me to disentangle the processes governing speciation in this group profiting from strong relevant experience of the host laboratory i will reanalyze available transcriptomic datasets together with newly sequenced genomes i will map precise directions of hybridization at the phylogenetic tree describe functional associations of introgressed loci test selection signatures associated with introgression and estimate the extent to which repeatable ecomorphological traits are underpinned by reusable elements of ancestral genomes this research has groundbreaking potential in providing a direct test of a potential catalysing role of hybridization in fast speciation in this system
a robust standardization roadmap towards boosting innovation to market for swappable battery systems for lcat vehicles deployment as a major contribution to safe secure resources and environmental

a robust standardization roadmap towards boosting innovation to market for swappable battery systems for lcat vehicles deployment as a major contribution to safe secure resources and environmental friendly and interoperable decarbonization solution of the mobilitytransport sector
neuronal circuits for sensorybody state integration

thermal homeostasis is essential to survival but how our brain processes thermosensory information and triggers behaviors that help maintain our physiological body state remains a mystery the neural circuits responsible for perception of sensory stimulation and those for regulation of body state have been studied independently yet body state has a profound impact on sensory perception what is more animals constantly adapt their behavior to maintain homeostasis with momentbymoment sensing of the environment current models suggest that the insular cortex plays a key role in integrating internal information about body state with external sensory information about the environment to generate signals that represent the difference between internal and external inputs such sensorystate difference signals allow us to navigate and adapt to a dynamic environment to test this model our aim is to leverage distinct features of the thermal system and examine species with and without the ability to thermoregulate my team has recently located the primary cortical representation of temperature a thermal cortex in a posterior region of the insular cortex we will examine its activity as we monitor and manipulate the internal core body temperature and external thermal input during robust and sensitive thermal behavior we will compare human and mouse which are warmblooded to naked molerats which are nearly coldblooded to identify the cellular mechanisms of sensorystate integration we will use a combination of cuttingedge techniques including neural recordings anatomical tracing and activity manipulations during a thermal perceptual task and thermoregulatory behavior our holistic and comparative approach will provide insight into a fundamental question regarding cortical function and may help tackle disorders of body state associated with insular cortex dysfunction
lagrangian climate risk and impact attribution

under a continued increase in global warming extreme events such as heatwaves will further rise in frequency intensity and duration over the next decades climate change impact studies routinely assess hazard and exposure change across discrete time windows but thereby fail to grasp how vulnerability and climate risk evolve across a persons lifetime conversely demographic research has a long tradition of assessing population processes and vulnerability from a cohort perspective but generally ignores climate impacts this project will develop novel concepts and methodologies to express climate change impacts and risk from a cohort perspective more specifically the project pursues i to reconstruct two iconic climate change impacts on people around the world using machine learning heatrelated mortality and burned area ii to uncover agespecific vulnerability to climate extremes including heatwaves wildfires river floods droughts tropical cyclones and crop failures iii to detect and attribute changes in lifetime extreme event exposure and climate impacts on mortality across generations and regions iv to quantify how these attributable cohort impacts change countrylevel life expectancy around the world under a range of warming scenarios and finally v to project how lifetime exposure to extreme events including compound events may trigger irreversible impacts under scenarios of temporary overshooting of longterm warming targetsby bridging physical climate science demography and planetary health lacrima will comprehensively identify whether and where people will live an unprecedented life in terms of climate impacts and how collective mitigation choices can alter the climate change burden on current young generations around the world