Dragon09/odtu_chatbot huggingface dataset:
twoloop renormalization of the smeft and the wet

the matching of the smeft onto the wet ie expressing the wet parameters in terms of the smeft wilson coefficients is known since recently up to the oneloop level these matching conditions depend however on unphysical entities and can therefore not be used in a consistent phenomenological analysis in order to remove this scheme dependence the twoloop renormalization of the wet parameters needs to be taken into account since it cancels this scheme dependence and therefore makes the results physical again one objective of the current research project is to compute the full twoloop renormalization of the wet wilson coefficients and implement the results in the public code wilson a second objective of the research project is to conduct the full twoloop renormalization for the smeft parameters performing the twoloop renormalization is motivated by the fact that at this order many more smeft wilson coefficients become phenomenologically accessible through running effects which therefore allows for a broader and more precise np search another goal of this computation is again to remove unphysical dependencies that are present in the matching conditions although the full oneloop matching from general bsm theories onto the smeft is currently unknown it is however expected to be available in the very near future together with the proposed calculation these matching conditions can then be used to perform a consistent and completely general nlo analysis of smeft parameters
network synergies in tissue homeostasis and stromal prevention of inflammatory disease

inflammation has evolved to protect us from the outside world however in doing so it consumes large amounts of energy and causes collateral damage thus requiring strict control on multiple levels while the mechanisms that govern inflammation once ongoing are well defined we lack basic knowledge of the processes that regulate its actual onset in vivo only by understanding the mechanisms that orchestrate tissue stress responses and defend against unwanted inflammation will we pave the way for new therapeutic approaches in future precision medicine not only treating inflammation once it is active but preventing inflammatory disease from developing in the first placei hypothesise that prevention of inflammation can be accomplished at the level of tissue homeostasis and cooperative stromal biology the stroma that underlies any given tissue is not a passive scaffold instead it comprises a functional network that regulates key aspects of tissue physiology as an adaptive and selforganising system homeostat resident tissue macrophages rtm the tissues very own regulators of inflammation are physically connected to this homeostat and thereby directly integrated into its cooperative signalling grid hardwired communication mechanisms and synergies allow rtmstroma networks to operate as a functional syncytium a hitherto unknown operating system that coordinates stress responses and actively prevents the onset of inflammation here i propose a pioneering tissue biology approach to decipher the stromal homeostat by combining unique bioimaging with computational 3d reconstruction and multidimensional profiling i will quantitatively unravel complex cell interactions to explain the mechanisms and implications of stromal network communication in a living tissue thereby i aim to elucidate homeostatoperating principles and establish topdown control of inflammatory tissue checkpoints in order to apply them to clinically relevant inflammatory diseases
two isotopes for neutrinoless double beta decay search

the tiny experiment will focus on the investigation of neutrinoless double beta decay 0n2b with 96zr and 150nd isotopes the search for 0n2b is a hot topic in particle physics as the discovery of this rare nuclear process would establish the majorana nature of neutrino fix the neutrino mass scale and prove lepton number nonconservation setting the grounds for new physics beyond the standard model the current and nearfuture largescale searches for 0n2b do not include the nuclei chosen for the tiny project due to the unavailability of an appropriate scalable detector technology for these candidates both 96zr and 150nd have the crucial advantage of very high transition energy for the 0n2b process which would allow obtaining a higher sensitivity to the effective majorana mass compared to other isotope candidates bolometric detectors with high energy resolution and active particle identification will be developed during the project execution 96zr will be embedded into zro2 crystals measured with thermal sensors and coupled to auxiliary light detectors for active alpha particles rejection 150nd will be studied with magnetic ndgao3 absorbers and athermal phonon sensors particle identification will be achieved via pulse shape discrimination the first ever efficient measurement of a magnetic compound as a bolometer will open the way to new opportunities in lowtemperature particle detection the tiny pilot experiment consisting of afewkg scale underground demonstrator will be able to set the best limits worldwide on the 0n2b halflives for both 96zr and 150nd isotopes very low background in the region of interest will be obtained thanks to high transition energy and alpha rejection not only will this project be competitive in the international context on a short time scale but also it will open up new perspectives for tonscale experiments that can surpass any existing technology in terms of sensitivity to the majorana neutrino mass
translational research and innovation in ophthalmology vision centre of excellence

eye diseases affect the daily lives of 22 billion people globally and have a significant socioeconomic impact however recent advances have rapidly progressed our understanding of the mechanisms of ophthalmic diseases opening unprecedented opportunities in the field of eye therapeutics the development of new technologies robotics ai and health services virtual clinics offers new solutions to improve the quality of life of ophthalmology patients and to reduce the costs and burdens for national healthcare systems in the triovi project we address these challenges focusing on translating the latest advances in science and technical research into practice in vision care together with strategic partners from ucl and sorbonne we create a centre of excellence the international center for eye research icter coe in warsaw a subunit of the institute of physical chemistry of the polish academy of sciences unlocking scientific and translational potential of icter coe guarantees tremendous impact on society science education and health by accelerating introduction of therapies and new solutions in vision care it will boost the rapidly growing biophotonics and biomedical engineering industry in poland by introducing new devices in ophthalmology as a result of triovi we anticipate a considerable improvement in rdi capabilities in ichf and icter through enhanced education training and integrated skill development for all employee groups with a focus on excellence gender equality and multidisciplinary collaboration thus we aim to strengthen the ri system in poland attract eu funding increase visibility of polish rd institutions in eu and beyond and substantially become a gamechanger for paradigm of ophthalmology in central europe by boosting the changes icter coe will become a lighthouse for the polish academy of sciences the largest research institute network in the country and the scientific landscape in poland and in the region
robot manipulation of deformables through dynamic actions

robot handling of deformable objects such as textiles is a research topic that has hit fertile ground with the advancement and accessibility of robot hardware a change in thinking of application of robotics also outside of factories and especially novel control and perception methodologies stemming from ai approaches the topic has sprouted different independent research efforts all over the world and in europe at jsi after some initial experiences we recognize the potential impact in academia and society of this new research area and believe we can become an important player we want to combine and bring forward separate efforts on this topic by making a network of academic and industrial stakeholders in combination with policy makers and regulators create a roadmap for the future and become a center of excellence coe in robot manipulation of deformables in the truest sense of the definition as a network of institutions collaborating with each other to pursue excellence in a particular area the proposed twinning project initiative romandic robot manipulation of deformables through dynamic actions will provide the means to promote this novel and exciting field of research at jsi and internationally but more importantly facilitate and consolidate the managing and leading capabilities of jsi through knowledge transfer and exchange of best practice so that it can indeed act as an informal coe the three participating institutions have the complementary expertise required to succeed in the research aspect of romandic and also the infrastructure and organisational experience required to create and promote best practices and lead initiatives at the national and international levels the three institutions collaborated already in the past in several eu projects
dependable smart energy systems

the dn dense is addressing individual research projects and training of doctoral candidates dcs in the innovative dependableengineering of smart energy systems sess with the main focus on robustness as well as preventive and corrective actions under uncertaintywithin this concept the term smart energy systems sess refers to a holistic crosssectoral approach eg electricity heating coolingindustry buildings and transportation aimed at excelling the transformation towards sustainable and achievable future energy systems hence it both covers but also extends beyond the smart grid approach which is mainly focused on the electricity sector consequently sess exhibit the following attributesi complex interactions on subsystem and crosssectoral systemsofsystems levelsii cyberphysical characteristics with digital and physical network connectionsiii ability to operate in nonstationary uncertain and severe environmentsdependability of complex networks such as sess characterizes their ability to deliver service that can justifiably be trusted thus dependability comprises system attributes such as availability reliability safety integrity and maintainability a key requirement of dependability is the desire for providing justifiable trust in the system performance hence rigorous systems engineering yielding provable performance guarantees throughout the systems life time is already required at the design stage this challenge is tackled in dense with a focus on operational robustness as well as preventive and corrective actions in sess as a consequence dense is wellaligned with the eu commissions headline ambitions on the european green deal as well as the strive for grasping the opportunities from the digital age while increasing social fairness and prosperity
research facility 20 towards a more energyefficient and sustainable path

research in many cases requires large infrastructures which often use significant amounts of energy in particular research at some of the largescale facilities such as particle accelerators which are either hosted or used at european level are very energy intensive power usage may reach 100 mw or more with energy consumptions comparable to small towns to make progress in science these largescale infrastructures are essential despite their energy consumption requirements at the same time our society is faced with the enormous challenge to transition into a carbonneutral economy and to minimize our footprint in terms of energy usage from nonrenewable sources and our output of substances which burden the environment for this reason research infrastructures need to develop and use energy efficient technologies the way we operate our infrastructures needs to be reevaluated intelligent solutions which reduce energy consumption need to be developed through intelligent algorithms the energy usage of our infrastructures needs to be adjusted to the available resources such as renewable energy and should help in providing an overall stable energy supply to societythe rf20 consortium vision is to design and operate accelerators in the way that they can run safe and stable anytime on 100 renewable energy supply ie almost independently from the public power gridto achieve this vision comprehthis projects originality lies in the comprehensive analysis of large research infrastructures energy management problem from component to system level both at experimental physics and energy engineering level and in developing and testing in realistic environments of possible corrective actionsthe rf20 project will involve 6 world renowned research infrastructures for the acceleration of particles of which 5 of european interest an energy technology lab and 4 smes focused on the codevelopment and technology transfer of new energy solutions
neutrinai energyfrugal internet of things networking with generative ai modules

this project aims to design energyefficient communication technology and protocol for the 6th generation 6g internet of things iot communication system in which energy efficiency is one of the essential key performance indicators kpis to realize sustainable iot networking the energyefficient protocol designs for iot devices serving 6g applications are more challenging than conventional wireless sensor networks as we need to consider the energy cost caused by the introduction of the artificial intelligence ai machine learning ml model as well as that of the primary radio circuit however most related works do not consider the energy cost of introducing the ml model which affects the overall energy efficiency of the communication protocols in order to realize the reduction of the overall energy consumption of aiempowered iot devices this project newly introduces generative ai modules and wakeup radio technology into iot devices operating with batteries by which iot devices can suppress unnecessary data transmission and communication is taken place in an energyefficient manner by cooperatively transmitting signaling informative data and ml model from devices to devices this project will design a new communication framework integrating generative ai modules investigate the systemlevel performance of gaibased communication systems and clarify the gain brought by the introduction of gai modules in terms of energy efficiency and accuracy
engineering and delivering b cells using biomaterials against breast cancer

breast cancer bc is the most diagnosed cancer worldwide and despite treatment availability the disease remains challenging to treat causing substantial adverse side effects and fatalities globally the lack of efficacy and inaccessibility of standard care supports this demand for better treatments this is demonstrated by resection surgery and current neoadjuvant therapies such as chemotherapy exhibiting inadequacies resulting in 30 of bc patients having metastases these percentages are even higher in low human index regions due to inaccessibility cost and growing populations adoptive cell therapy act such as cart is a category of emerging immunotherapies expected to impact oncology by transferring engineered immune cells into a patient to eliminate cancer cells however these treatments are currently ineffective in bc and costlyendbc will complement research into b cells to produce an act that improves treatment efficacy against breast cancer while reducing side effects and costs from effective therapy our research developed novel biomaterial to overcome significant obstacles to successfully enhance b cell functions against cancer using a lowcost method in endbc we will research the commercial and technical feasibility of tailoring the b cell act with biomaterials to determine its potential to treat bc
taking action to prevent and mitigate pollution of groundwater bodies

groundwater is a key resource for water supply which is currently jeopardised by i saline intrusion ii pollution with pesticides and nutrients agriculturefarming pharmaceuticals and antibiotic resistance genes from wwtp effluents hydrocarbons and heavy metals runoff and microplastics both iii global and climate change effects although several initiatives have developed actions and tools towards groundwater monitoring and protection additional knowledge is needed to understand the synergistic effects and risks of multiple stressors and pollutants and to develop costefficient groundwater monitoring strategies pollution preventionmitigation technologies and earlywarning dss ninfa will provide a novel strategy based on an earlywarning dss and knowledge database ninfa platform and innovadiffuse pollution affects 35 of the area of groundwater bodies with contaminants such as pesticides herbicides and nutrients leading to eutrophication and lack of oxygen other pollution sources including sewage from wastewater treatment plants wwtps and runoff infiltration in cities especially during storm events contaminate groundwater with contaminants of emerging concern cecs such as pharmaceuticals microplastics and antibiotic resistance genes and with hydrocarbons and heavy metals respectively moreover aquifer exploitation for water consumption leads to increased pressure on groundwater resources which may be aggravated by climate change lack of aquifers natural recharge in coastal aquifers this problem is worsened due to saline intrusion mainly caused by water extraction which affects the quality of the groundwaterthe innovative concept of ninfa is to facilitate the transition to a more effective decisionmaking system in groundwater management by widening the knowledge on water flows the insitu mobility and transformation of cec and establishing predictive models to promote the treatment and reuse of water and its quality
advancing measures to reduce aviation impact on climate and enhance resilience to climatechange

the interconnection between aviation and climate is very tight on the one hand air traffic contributes to greenhouse gas emissions that alter the composition of the atmosphere globally hence driving climate change on the other hand atmospheric processes significantly impact the whole chain of aviation changes in temperature affect infrastructure and aircraft performance variable wind and precipitation patterns increase delays and cancellations etc in recent years researchers put a strong effort in investigating the impact of aviation on climate and ways to mitigate it putting these knowledge advancements into practice requires further development of the climate impact assessment methodology towards the deployment and implementation phases in addition to these efforts new adaptation measures are necessary to make the aviation sector less vulnerable to the unavoidable changes in climate conditions which we are already experiencing such as heatwaves and other highlyimpactful weather phenomenaobjectives the project aims at developing a toolset for reducing the aviation impact on climate and to enhance the sectors resilience to climate change the idea is to advance the knowledge and operationalize the monitoring on the impact of aviation on climate and concurrently to assess the resilience of the aviation sector to the exacerbation of extreme events due to climate change
control of host mechanics by a bacterial pathogen and functional impact

mammalian cells sense and exert forces on their environment and their responses to mechanical signals regulate their growth motility and behavior within tissues however little is known about the forces at play during microbial infections and their impact on tissue homeostasis and disease progression i recently found that binding of the extracellular bacterium neisseria meningitidis nm on the endothelium leads to the generation of large traction forces on the extracellular matrix this is due to the formation of a new structure that i called ancreopodia linking the bacterial colony on the apical side of the host cell to the basal side and underlying substrate i hence hypothesize that nm induces longrange force transmission throughout the infected cells leading to alterations in tissue functionin this project i propose to dissect how host cell mechanics is affected by nm infection and how mechanical forces globally impact tissue barrier physiology in epithelia and endothelia by developing quantitative tools to directly measure forces while imaging host cells during infection both in vitro using 2d and 3d models of tissue barrier with increasing complexity and in vivo i will 1 identify the key molecular mechanisms involved in host cell structural remodeling and their regulation in space and time 2 characterize the mechanics of the infected host tissue using biophysical tools and theoretical approaches to link signaling to the forces involved and 3 study the functional consequences of infectioninduced mechanical imbalance on cell fate and host tissue integrity this study has a double interest to better understand the impact of mechanics in the process of infection for the development of new therapeutic strategies and to bring new fundamental knowledge on the mechanical homeostasis of tissue barriers by integrating extracellular pathogens as new tools to shed light on complex feedbacks between cell architecture mechanics and function
plantpowered energy harvesting system for iot solutions

plante is the worlds only company harvesting energy from living plants without harming them a womenled startup plante launched in 2009 as a spinoff of wageningen university based on the phd research of marjolein helder our ceo plantes team has 20 years of commercial experience multiple phds and 10 years of rd experience in this field pushing our growth to 2 granted patents and 3000 prototypes tested so far with a business model based on device sales and maintenance fees we entered the smart lighting and sensoring market with custom projects the park of tomorrow in rotterdam nl is an interactive lighting system in a park and together with esa data was collected and sent into space by pmfc power plante technology doesnt emit any greenhouse gases such as co2 or methane on the contrary it acts as a carbon sink capturing up to 2 kg of co2kwh produced as such plante contributes to the zero pollution and carbon neutrality ambitions set by the eu