Dragon09/odtu_chatbot huggingface dataset:
dissecting macrophage mechanobiology to engineer immunoregenerative biomaterials

there is an increasing clinical demand for sophisticated medical implants and the scientific field of implant technology is exponentially growing the main challenge is to harness the immune response to such an implant in this research we use the immune response to our advantage by using bioresorbable synthetic biomaterials that are gradually replaced by living tissue inside the body one of the key immune cells are macrophages which are the gatekeepers for successful implant integration strategies to harness the macrophage response focus on isolated biomaterial design features such as biochemical or microstructural modifications one major neglected factor is how macrophages sense and respond to mechanical loads such as cyclic stretch or macrophage mechanobiology without an indepth understanding of macrophage mechanobiology rational engineering of biomaterials is not possible leading to unpredictable outcomes and ineffective trialanderror work with macxercise i will leverage my unique multidisciplinary expertise in bioengineering biomaterial science and macrophage biology to address these scientific challenges from a new angle in which macrophage mechanobiology is placed center stage the main aim of the macxercise program is to systematically dissect how macrophages respond to dynamic mechanical cues and to establish how this affects biomaterialdriven tissue regeneration the transformative strength of macxercise lies in the concerted spatial and temporal manipulation of the macrophage microenvironment using sophisticated engineering tools to decouple the mechanical and physical cues to systematically pinpoint how synergistic or conflicting cues dictate key macrophage functions in the biomaterial microenvironment with macxercise my vision is to catalyze the establishment of an exciting new research field across the boundaries of biomaterial science immunology mechanobiology and tissue engineering
circular economy for the sustainable earth spheres geosphere biosphere hydrosphere atmosphere

one of the main building blocks under the green deal policy is the circular economy action plan focusing on sustainable resource use design and production for a circular economy with the aim to ensure transform the eu into a modern resourceefficient and competitive economy ensuring economic growth while improving the wellbeing and health of citizens and future generationsincreasing the number of expert researchers and key profiles in the field of circular economy within the scope of the eu green deal is of great importance for the fulfilment of the determined policy objectives ecosphere is a cofund postdoctoral programme focusing on circular economy for sustainable product design and resource efficiency offering 24 postdoctoral fellowships of 24months length in diligently designated research areas on ecodesign energy waterwastewater material recovery waste management economic policy climate change sustainability and business models ecosphere is coordinated by the department of environmental engineering at yildiz technical university in collaboration with dokuz eylul university the 5year programme will be executed in a broad range of research areas incorporating circular economy weighing european union circular economy action plan european green deal united nations sdgs and paris agreement circular economy studies for resource and energyintensive sectors will be carried out in order to ensure sustainable development together with all stakeholders in which people planet and profit are handled in an integrated manner ecosphere will concentrate on industries with high circularity potential such as electronics and information technology automotive packaging plastics textiles construction food water and energy moreover ecosphere will have a humancentric approach and focus on empowering consumers and providing them with costsaving opportunities making circularity work for people and cities
roles of cytoplasmic bridges in cellcell cohesion and communication

during development cells divide and make fate decisions canonically cell division ends with the severing of the link between daughter cells in the process called abscission yet across the tree of life cells can remain connected through cytoplasmic bridges by delaying or inhibiting abscission curiously while bridges are important conserved structures sustaining cellular function there are little evidence to explain how bridge impact cell function the aim of the proposal is to investigate the hypothesis that bridges are conserved organelles critical for cell function by providing unique mechanical connexion and an important intercellular communication channel in particular we will leverage our expertise in live imaging of cell division and biophysics as well as a combination of newly developed genetic and optogenetic manipulations to determine 1 the role of bridges as a mechanical coupling between connected cells we will test the contribution of cytoplasmic bridges in creating a physical link between cells and the consequences of disturbing this cohesion for cell function2 the role of bridges as an exchange route between connected cells we will investigate how the regulated exchange of cellular material through bridges impacts cell functionas bridges can have a simple or a complex structure that could be critical for their function we will use 2 model systems the choanoflagellate salpingoeca rosetta where a structurally simple bridge sustains cellcell cohesion and mouse embryonic stem cells where bridges are structurally more complex while traditional models of bridges are difficult to manipulate both our models are easy to culture and provide an experimentally tractable system that can shuttle from a unicellular to a multicellular organisation the comparison between these two model systems will allow us to understand how a fundamental step of cell division could crucially impact the function of cells in a multicellular context
the ultralow frequency universe

the ulu project will explore the largest scales of our universe mapping one of the last uncharted observational windows of the cosmic electromagnetic spectrum the ultralow radio frequencies 10100 mhz although these frequencies are crucial to unveil the nature and evolution of galaxy clusters the complexity of such observations prevented their exploitation until now techniques i developed to analyse low frequency array lofar data were able to overcome this limitation with ulu we will survey the northern sky producing ultralow frequency images that are 100 times more sensitive than the stateoftheart the legacy of ulu will be long lasting with a far reaching scientific outcome from galaxy evolution to ionospheric science from exoplanet habitability to the detection of the first galaxies at cosmic dawnwithin the ulu project i will combine the survey with my expertise on the study of galaxy clusters my group will adopt an innovative approach based on unveiling the full picture of the cosmic ray cr lifecycle in the intracluster medium effectively combining diverse topics historically studied independently such as the growth of structures agn activity and galaxy evolution while conventional radio frequencies are sensitive to emission generated by highly energetic crs with ulu we will explore the far larger domain of lowenergy crs that can be accelerated by still unexplored microphysical mechanisms furthermore their emission can be observed over gyr time scales revealing the longterm actions and interactions of radio sources in cluster environments with a full picture of the cr lifecycle we will 1 unveil how cluster merger energy is deposited in the intracluster medium through shocks turbulence and other mechanisms 2 measure the longterm effect of agn feedback up to the age of cluster formation and 3 make a realistic attempt at the characterisation of the whim properties and constrain the origin of cosmological magnetic fields
ur4energy underwater robots for efficient ocean energy harvesting

the renewable energy input in the grid is not sufficient to cover the european energy demand which largely still depends on fossil fuels to reach the goal of climate neutrality by 2050 europe needs to diversify and improve the adoption of renewable energy technologies a yetuntapped source of energy can be found in the ocean while wave and tidal energy have been explored the reliable and predictable vortex wake energy has not been harvested yet as a renewable energy source ur4energy will tap into this energy source by developing an efficient way to harvest it by using underwater robots in this project prof pettersen will prove the technical and commercial feasibility of an underwater robot for ocean energy harvesting prof pettersens group will integrate the expertise of two partners ie inventas as and ntnu technology transfer as for the development of the prototype and the monitoring of the patent landscape respectively ur4energy contributes to the ocean energy market one of the fastest growing renewable energy markets cagr 20222030 335 with a versatile technology that has the potential to support the eus independence from fossil fuels while contributing to research on robotics and autonomy for underwater robots
direct selective laser trabeculoplasty dslt accessible glaucoma care in seconds

our novel laser technology direct selective laser trabeculoplasty dslt is an automated laser procedure for accessible primary treatment of glaucoma and ocular hypertension our eagle device has the potential to revolutionize glaucoma care as it is noncontact intuitive and quick the technology is groundbreaking as the procedure doesnt require expertise and involves simply pressing a button and delivering treatment in seconds dslt technology is poised to achieve widespread acceptance as it is not limited to glaucoma specialists or bound to glaucoma medication compliance in addition our technology is supported by promising firstinhuman clinical trial results as well as the expertise and guidance of key opinion leaders in the field of ophthalmology eic funding will support belkin laser rebranded recently as belkin vision in commercializing this sightsaving technology by establishing the commercial value chain market launch and scaleup
pyrolysis of biomass by concentrated solar power

pysolo pyrolysis of biomass by concentrated solar power project aims at preparing the ground for a novel groundbreaking and fully renewable process combining concentrated solar power and biomass pyrolysis thanks to the use of solar heat in the pyrolysis process the production of valuable products biooil biochar and pyrogas can be maximized and the associated co2 emission minimized with economic and environmental benefits compared to conventional pyrolysis the proposed system uses particles heat carrier ensuring operational flexibility and avoiding the need of heat transfer surface in the pyrolysis reactor that facilitates the system scaleup specifically pysolo process aims at developing at trl4 the two key unit operations of this novel solar pyrolysis system namely i the solar particle receiver and ii the pyrolysis reactor with the associated particlechar separator the very innovative feature of pysolo lies in its innovative and unique coupling of pyrolysis technology with high temperature csp system this groundbreaking feature can potentially offer the following main advantages delivering solar biooil electricity or pyrogas and biochar for many energy and nonenergy uses when solar energy supplies the heat necessary for the pyrolysis process either in sunny hours or by exploiting high temperature stored solids run in selfmode the pyrolysis process ie with electric heating or burning pyrogas and biochar when solar energy is not sufficient and the tes unit is discharged providing balancing services to the electric grid 1 from the conversion of the available pyrogas when solar energy or tes are sufficient to maintain the pyrolysis process running and the grid requires the generation of additional electric power 2 by using lowcost excess electricity from nonprogrammable res ie pv and wind and converting it in high temperature thermal energy via the induction electric heating system
engineering vascularized implants for personalised osteochondral tissue regeneration from medical imaging to preclinical validation

osteochondral injuries oci is a challenging yet common clinical problem for orthopaedic surgeons worldwide and is associated with multiple clinical scenarios ranging from trauma to osteonecrosis strategies for functional tissue regeneration at still far from the clinics and should endeavour to heal the subchondral bone and joint interface and hyaline cartilage enhancing the understanding of the mechanisms that underlie oci holds the potential to unlock groundbreaking advancements in therapeutic interventions engvipo tackles current challenges in the realm of biofabricated patientspecific implants with enhanced vascularity and functionality concerning scientific expertise and collaborations with renowned institutions for oc tissue engineering within the interdisciplinary domains of 3d computational modelling advanced manufacturing 3d in vitro models and nanotechnology and boosting clinical translation of the tissue engineered products the project is focused on catapult knowledge exchange and create research synergies on the development of innovative biomaterials and bioinks emerging technologies biobanks and personalized medicine for the complete regeneration and establishment of normal function of injureddiseased oc tissue this will range from advanced biomaterialsscaffolds incorporating bioactive ions with osteogenic function implementation of innovative manufacturing technologies spheroidsorganoids integrated into microfluidics therapeutic biologicals and biobanks in silico modelling in vitro immunocompatiblity to in vivo evaluation such innovative approach represents a significant advancement in the field of orthopedics leading to improved participation of biobanks towards the development of advanced implants and patient outcomes and setting new standards for personalized implant solutions
the eu navigating multilateral cooperation

how should the eu navigate the increasingly complex and conflictladen institutional spaces of global governance to advance a rulesbased international order and what factors should be emphasized when considering which institutions to strengthen which to reform and which to bypass when revitalising multilateralism navigators main objective is to answer these questions and deliver a readytouse search mechanism and associated pathways of action that the eu and its member states can use as it seeks to strengthen a rulesbased international order to achieve this navigator comprises a strong global and interdisciplinary team of researchers who explores institutional variation on six policy issues climate change digitalisation financetax health migration and security to identify what institutional mixes that enables the eu to have optimal impact in a given policy issue we explore variation in formality formal to informal accessibility open to closed and normativity expressed purpose is technical to openly normative drawing on these data and complementing these with content analysis social network analysis semistructured interviews and european and global surveys navigator develops a search mechanism that allows the eu and member states to compare strengths and weaknesses of existing multilateral organizations determine which can be reformed and which are too costly to reform identify and assess alternatives and on this basis develop action strategies to reform multilateralism navigator will be very relevant to the work programme as it will assess the effectiveness of multilateral institutions and arrangements identify the optimal pathways of action of eu support to multilateral minilateral private and publicprivate initiatives to further global governance in a given policy domain and provide recommendations for eu engagement strategies in the context of the war in ukraine threats of nationalism and antieu populism
performance precision annotator ppa aiassisted annotation and analysis of music performance

in the internet era vast troves of sound recordings and musical scores have become available to virtually anyone but drawing connections between these two mediums to develop insights about performance style and artistic expression has remained a difficult and timeconsuming task currently music scholars rely on generalpurpose sound editing tools for annotating musical elements in recordings such as downbeats pitch or note onsets however these annotations often must be entered manually and these tools do not incorporate one vital element needed for analyzing recordings musical score information this approach can be labor intensive and inefficient and limits the scope of the data that can be analyzed to help address this need we seek this fellowship to develop ppa a prototype opensource software tool for annotating and analyzing recorded music performances bringing innovations from the interdisciplinary music information retrieval mir community to scholars and musicians in the humanities provided with a digital musical score and a performance of that score the software will automatically generate meaningful aidriven annotations about eg note onsets dynamics articulations or tempo fully integrated with the score with an easytouse graphical user interface the software will display and visualize the score the audio and the selected annotations in intuitive ways designed to streamline performance analysis besides developing the prototype we propose to conduct usecase studies gathering evidence to illuminate ways ppa can be used to assist musicology scholarship and to inform future development of the software
sample complexity for inverse problems in pde

this project will develop a mathematical theory of sample complexity ie of finite measurements for inverse problems in partial differential equations pde inverse problems are ubiquitous in science and engineering and appear when a quantity has to be reconstructed from indirect measurements whenever physics plays a crucial role in the description of an inverse problem the mathematical model is based on a pde many imaging modalities belong to this category including ultrasonography electrical impedance tomography and photoacoustic tomography many different pde appear depending on the physical domain currently there is a substantial gap between theory and practice all theoretical results require infinitely many measurements while in all applied studies and practical implementations only a finite number of measurements are taken we argue that this gap is crucial since the number of measurements is usually not very large and has important consequences regarding the choice of measurements the priors on the unknown and the reconstruction algorithms many safe and effective modalities have had very limited use due to low reconstruction quality within a multidisciplinary approach by combining methods from pde theory numerical analysis signal processing compressed sensing and machine learning we will bridge this gap by developing a theory of sample complexity for inverse problems in pde this will allow for the deriving of a new mathematical theory of inverse problems for pde under realistic assumptions which will impact the implementation of many modalities guiding the choice of priors and measurements consequently emerging imaging modalities will become closer to actual usage as a byproduct we will also derive new compressed sensing results which are valid for a general class of problems including nonlinear and illposed and sparsity constraints collaborations with experts in the relevant fields will ensure the projects success
terminal airspace digital assistant

tada is a project aimed at improving terminal airspace tma performance through the use of atco generated historical data and ml to provide the atco with decision and action selection for future situations presented in a human centric waytmas especially those serving major airport hubs andor multiairport systems are areas of heavy congested traffic busy tmas could benefit from further automation that would improve capacity flow and trajectory efficiency and safety the current atc paradigm in tmas consists of having flights and their intentions identified by the air traffic controllers atcos supported by a series of information acquisition and analysis tools such as aman providing a sequence trajectory predictions safety nets and instruction adherence monitoring most of which are integrated into the atm system in use atcos assimilate the information available incorporate other background information make decisions and instruct the flights they also interact with the atm system to keep it up to date with the decisions and the feedback received from the flightsthis atco data gathered through this interaction is currently barely used beyond the immediate information update cycles and possibly post ops investigations this wealth of bigdatatogether with the introduction of machine learning ml algorithms that will learn to predict patterns and atc instructions can be taken advantage of much more to improve capacity efficiency and safety by providing decision making support to atcos and delegation of certain tasks a digital assistant and corresponding hmi will be developed through tada and aman will benefit from an improvement through the use of the same data and mltada will be carried out by a consortium of 6 partners from 6 different eu countries including academia ansp atm system provider and an expert company in ai bringing complimentary academic technical human factors and operational skills and expertise to the project
immersive games for museums as vehicles to engage visitors in empathetic responses

mementoes will build immersive video games to service the needs and facilitate mass audience affection for museums engaged in the topics of memorialisation and transitional justice the goal is to create authentic storytelling experiences where people places and original items are used to maximum effect to fulfill the museums responsibility to provide immersive deeply personal experiences that aim to demonstrate empathy toward their communities through cuttingedge technology such as virtualmixed realityhighquality digitisation techniques ai for explorative procedural content generation and accessible interaction techniques mementoes will deliver a universal experience where distant people and places will become palpable and present to the players mementoes will involve a multidisciplinary team of museum curators designers and exhibit developers as well as technology providers and visionary game developers so as to uncover the types of connections museum visitors are making enabling the game makers to understand the types of education techniques and behaviors that foster historical empathy and tangential learning outcomes and draw appropriate parallels to game storytelling frameworks three game will be developed each targeting an authentic museum recognised internationally as a site of conscience to help get deliver the museum messages to wider audiences from around the world transcending even the boundaries put in place by the recent covid19 pandemic mementoes will further facilitate a liaison with the outcomes of horizoncl2heritage20210109 games and culture shaping our society contributing with its evidence on games as a vehicle to engage cultural institution visitors in empathetic responses