Dragon09/odtu_chatbot huggingface dataset:
2d topological superconducting single photon detector devices

superconducting single photon detectors are critical components for emerging quantum technologies due to their high detection efficiencies short jitter photon number resolution high maximum and low dark count rates these devices may enable new groundbreaking applications in topological quantum computing and quantum internet niobiumbased nanowires nb nbn are some of the most used superconductors for photodetection but their material characteristics device jitter and efficiencies cannot be effectively tuned or reproduced for scalable quantum technology deployment the structural and electronic properties of these nanowires are not suitable for scalable cryogenic or room temperature readout the challenges in growing highquality quantum materials consistently provide a significant bottleneck against the development of quantum technologies that might efficiently interface with conventional microelectronics in my erc grant 948063 we are using our pulsed laser deposition pld and molecular beam epitaxy mbe expertise for magnetic topological insulators mti and garnets for spintronic and superconducting devices with high conversion efficiency between electronic spins and charges here i propose to develop three prototypes and obtain their patents 1 three mti superconductorbased single photon detector prototypes with beyond stateoftheart high efficiencies and ultralow jitter owing to the unique properties of mti such as ultrafast subps magnetization reversal ballistic transport of dirac electrons along the interfaces and integrated spin logic 2 we are going to provide a steady supply of highquality superconductor and spintronic films nbn mti and magnetic garnets to accelerate basic and applied research which is a market growing with about 20 annual rate 3 a custom lowcost cryostat for 23k detector tests will be prepared with fiber optical and rf cable feedthroughs electromagnets readout electronics and software
integrated niche theory linking environmental compositional and functional change on coral reefs

idea coralint aims to deliver the ability to predict spatiotemporal change in biodiversity and the consequences of this change for ecosystem function to achieve this aim i will develop an integrated niche theory linking three niche concepts grinnells niche what a species needs eltons niche what a species does and niche construction how the species function changes the environment the key to this integration lies in how species are sorted along each of the niche axes environmental gradients functional rates and niche construction rates i will map the dynamic implications of different types of bivariate sorting to the development of positive and negative feedback loops this new theory will allow predicting the indirect consequences of selection on one axis to change along the other two axes i will test int with environmental compositional and functional data extracted from 3d maps of coral reefs and its coral inhabitants ground breaking features coralint sits at the interface between theory development and cuttingedge empirical data i anticipate coralint will produce 3d maps for a total area of 26600 m2 with mm scale resolution distributed among 100 sites along a 2000 km latitudinal gradient within these maps we will follow 100000 coral colonies through time measuring and inferring structural and demographic rates across 200 species and environmental variation in space and time working at organismal and ecosystem scales will enable coralint to develop mechanistic understanding of the processes connecting environmental compositional and functional change objectives develop a new integrated niche theory quantify the effects of the environment on corals distribution and functional rates determine if function can be predicted from coral and reef structural traits quantify the prevalence and evolutionary implications of coral niche construction feasibilitywe have collected proof of concept data for each data type
developing multifunctionally optimal composite structures for construction and transportation applications with an emphasis on environmental sustainability

due to unmitigated global warming the eu has suffered unprecedented heatwaves in 2022 resulting in over 12000 deaths and europes worst drought in 500 years this is attributed to the heavily fueldependent construction and transportation sectors collectively responsible for around 60 of eus greenhouse gas emissions in 2020 the chief reason lies in these industries overreliance on legacyoutdated component architectures with limited lifecycles and nonoptimal functional performance consequently there is an urgent ecologicalsocietal need and associated research challenge for tailoring alternative optimized composite structures that are sustainable ecofriendly and suited for commercial deployment multiopstruct aims to deliver an integrated design environment capable of addressing these concerns by adopting a highly interdisciplinary methodology inspired by the materialbydesign outlook and greatly expanding the current stateoftheart by coordinating cutting edge research on the modelling side the work will develop a novel rapid and highfidelity physicsbased method custom fit for analysing such complex components on the design side the project will deliver the first ever hybrid multiscaleartificial intelligence topology optimization toolbox for multifunctional lightweight additively manufactured am composite structures with increased durability and thermalvibroacoustic isolation and decreased netcosts this will reduce fuel dependency and associated emissions and subsequently alleviate problems induced by climate change eg glacier retreat these goals are strongly aligned with the circular economic action plan european green deal and fit for 55 policy for succesful completion the proposed research plan brings together an enthusiastic and talented researcher with expertise in computational mechanics with an interdisciplinary team of internationally recognized research groups in applied mechanics and additive manufacturing
scalable solutions optimisation and decision tool creation for low impact saf production chain from a lipidrich microalgae strain

cocpits ambition is to enhance the saf production chain by bringing groundbreaking innovations at each thread of it it aims also to provide investors with a human centred decision tool in a test before invest spirit with a high confidence level to derisk investmentsa lipid rich microalgae strain is cultivated in an intensified reactor coupled to semitransparent photovoltaic panels transforming harmful light spectrum into electrical power the transformation of algal biomass into saf is studied using two alternative pathways the most mature one hefa and a very promising one htl the project focuses on the circularity productivity sustainability and economic viability of the chain for hefa pathway efficient low impact and regenerable ionic liquids are used to extract lipids and to catalyse hydrotreatment for htl pathway a continuous reactor tailored to saf production from the chosen strain is designed and constructed to reduce clogging issues and to size with higher precision the heat exchangers furthermore the mechanistic models that are developed and used in the design increase the scalability of the htl biocrude upgrading is led to give a high flexibility between saf and shipping fuel production the system is designed in a circular way to reduce byproducts feed system with endogenous hydrogen recirculate nutrients and reduce its water intensivenessthe whole integrated system is simulated with unism software and all technical economical environmental and life cycle indicators are calculated under the cocpit decision tool and typical scenarios are compiled the decision tool is delivered within a marketplace that puts at investors service a range of required technological solutions equipment and skills it helps them also to choose the best technology that fits their project specificities the ambition of this tool is to continue growing up after the end of the project to include all certified and promising saf production pathways
anticipate disease outbreaks in fish farming

with a growing demand for protein sources aquaculture is postulated as a sustainable solution to meet this market need however fish farms are facing serious problems of fish mortality andor the need to treat diseases with antibiotics as there is a lack of technological solutions to anticipate the appearance of infectious pathogens among the different sectors that suffer from this problem aquaculture is the vertical whose market is estimated to have the greatest growth potential within the food industry regardless its little technological development current solutions in the market cannot detect pathogens onsite in a continuously and autonomous manner without giving farmers the chance to prevent undesired bacterial growth lowering down reaction times as a result of this lack of capacity to anticipate pathogen infections aquaculture companies face the following problems 1unwanted fish mortality due to late diagnosis of infections 2the need to use antibiotics decreasing the quality of the product produced and increasing the environmental impact 3increased production costs due to low productivity and increased technical costs associated with sanitary controls and treatments 4sustainability problems caused by the generation of food waste loss of animal welfare and the use of chemical products that are harmful to the environment all these problemas resut in economic cost of 6 byear and losses of between 20 and 30 of production in response to these problems koa was founded with the aim to develop an integral device that autonomously monitors pathogen concentrations in fish tanks and keep track of its evolution over time leading to relevant economic and production savings
towards understanding human consciousness how internal brain states and environmental context shape our subjective experience

consciousness is subjective experience the what it is likeness for example to perceive a certain scene or to feel joy in the last three decades tremendous progress has been made in identifying the neural correlates of consciousness at the level of whole brain regions meanwhile outside the field of consciousness rapid progress has been made in understanding neural biochemical and psychological factors that have to be accounted for to further understand human consciousness most importantly we know much more about the neurotransmitter systems underlying basic sensory processes in animals eg neurobiology the mechanisms responsible for fluctuations in wakefulness and arousal eg anestheticsneurobiology and how perception is constructed by the brains predictions about regularities in the world eg neurosciencepsychology this research has however been performed in relative isolation from studies of human consciousness and clear opportunities to link these different fields remain largely unexplored here i will establish this crucial link by combining stateoftheart neuroimaging techniques with pharmacological interventions and computational modelling in humans performing novel experimental tasks gauging subjective perceptual experience my project has 3 main aims i will first test the hypothesis that excitatory and inhibitory neurotransmitters play central albeit different roles in recurrent neural processes crucial for conscious experience second i will test how subjective experience is shaped by spontaneous fluctuations in arousal and levels of physical activity third i will test how conscious experience is modulated by the interplay between predictions and sensory input this research promises to provide an integrative framework for understanding the neural and biochemical mechanisms of consciousness and will reveal how it is shaped and determined by being a human agent that interacts with acts in and predicts its environment
3d screening system to cultivate tissue and automatically stimulate and quantify its mechanical properties

the way from potential drug candidates to clinically approved new medication is long and expensive to improve this we will provide the tissmec system that can create 3d human tissue while providing an automated and scalable way to quantify potential problems of drugs and other compounds of interest our tissmec system can not only measure the force generation of muscles and other contractile tissue but also continuously determine the viscoelastic tissue properties while mimicking mechanical situations that are known hallmarks of several critical diseases up to now obtaining such information is either not possible or requires slow and expensive manual work hence an automated scalable and standardized 96 well system that can quickly screen properties on human tissue can become a gamechanger as it identifies problematic drugs and compounds very early in the drug development process we have a laboratory prototype trl4 that already demonstrates these capacities and the proposed poc project will develop this lab version into a userfriendly trl6 prototype that we can give to our partners in pharmacology and toxicology and to already wellestablished industry partners our team is composed of 5 scientists spanning physics biology chemistry data science and economy hence we not only have invented a new technology to greatly improve an urgent current problem but also have a powerful network and outstanding team to ensure the success of our project
linguistic texts of roman antiquity collecting fragments sources and lexicon in a digital environment

all modern histories of western linguistics start with its greek origins 5th 3rd cent bc and then after mentioning the latin republican polymath varro 1st cent bc jump several centuries to explore only some prominent late figures 4th 6th cent ad the aim of the litera project is to provide a holistic perspective on the birth and configuration of roman linguistic science 2nd cent bc 3rd cent ad an essential moment in the evolution of western culture although we have inherited valuable sources from the late latin grammatical tradition this project will shed light on the overlooked works of the preceding republican and early imperial periods a vast body of texts which have not survived in their entirety but have been excerpted and quoted in late normative handbooks commentaries and lexica literas three interrelated objectives illuminate how the history of ancient roman linguistic thought can be substantially rewritten by mobilizing a heuristic step to collect all of the foundational fragmentary texts of latin grammar written by a hundred authors and transmitted in the sourcetexts of late antiquity a hermeneutic step to contextualize the interpretation of the lost texts extending the sources of latin grammar to the wider context of ancient roman scholarship a historical step to reconstruct the evolution of latin grammatical terminology from its historical roots in the reference corpus of sourcetexts to its modern conceptualizationliteras unique approach to decipher the internal correlations between these related corpora which are not at all mutually exclusive will necessitate new methodologies that consider their textual polyphony and intricate technical vocabulary litera demonstrates that examining these interconnected issues can only be accomplished in a digital environment that guarantees the interoperability of its objects
semantics of software systems

what if we had software bots that tirelessly test debug and monitor our software systemsit workers are expensive and scarce so why cant we further automate boring repetitive activities such as testing and debugging the problem is that we lack computerreadable specifications socalled oracles for what the system should do or not do for decades this oracle problem has been a roadblock to automated test generation trusted software repairs and accurate monitoring of software building on groundbreaking research to infer input languages of systems s3 introduces a unified approach to learning oracles automatically it takes a given software system
sobigdata ri preparatory phase project

sobigdata ri with its tools and services empowers researchers and innovators through a platform for the design and execution of largescale data science and social mining experiments open to users with diverse backgrounds accessible on cloud aligned with eosc guidelines and also exploiting supercomputing facilities sobigdata ri will render social mining experiments more efficiently designed adjusted and repeatable by nondata scientists domain experts by pushing the fair findable accessible interoperable and fact fair accountable confidential and transparent principles sobigdata ri will orient resources from multiple perspectives einfrastructures and online services developers big data analytics and ai complex systems focussed on modelling social phenomena elsec ethical legal socioeconomic and cultural aspects of data protection as defined by the hlegai privacypreserving techniques sobigdata ri ppp will move our ri forward from the simple awareness of ethical and legal challenges in social mining to the development of concrete tools that operationalize ethics with valuesensitive design incorporating values and norms for privacy protection fairness transparency and pluralism
the role of social presence on moral decisionmaking realistic settings for the understanding of utilitarian and deontological preferences

in our modern societies moral situations often refer to saving hurting condemning or sparing peers the direction of our moral preferences eg utilitarian deontological is inherently shaped by social norms and social context however current experimental research on moral cognition suffers from two main limitations first while a wealth of research has examined individuals moral preferences in single settings no research to our knowledge has examined individuals moral preferences in reallife social settings second because of the longstanding paradigm involving the use of hypothetical and sacrificial dilemmas to measure decisionmaking ie save or sacrifice lives we assume there is a discrepancy between hypothetical and realistic moral decisionmaking compared to the current stateoftheart yourmorals will allow for the first time to assess the role of social presence on individuals moral preferences shedding light on both cognitive and neural processes underlying responses to realistic scenarios this research will combine behavioural and neurophysiological paradigms by using a unique experimental system allowing to mimic social context through dyadic interactions the proposed experiments will permit to clarify the role of social presence through 1 indirect exposition to others moral choices single setting 2 direct presence of other social setting the latest innovative eegbased hyperscanning techniques will be used to measure multiple brains activity we will also construct an open standardized and realistic moral dilemmas dataset as well as opening new perspectives in social neuroscience and psychology this project will add theoretical and methodological expertise to my skillset by providing the most suitable research environment for my career development at the moral and social brain lab in one of the topranking universities of europe ghent university under prof emilie caspar supervision
functionalized lowcost graphene sponge electrodes for sustainable water treatment and complete defluorination of per and polyfluoroalkyl substances pfas focus4pfas

the presence of toxic carcinogenic and bioaccumulative per and polyfluoroalkyl substances pfas in our water cycle is one of the major challenges that the humanity is facing in the 21st century and there are no established wastewater treatment technologies capable of their degradation here we will address this challenge by developing lowcost graphene sponge electrodes tailored to achieve efficient electrosorptionadsorption and subsequent electrochemical degradation of pfas emphasis will be placed on the removal and degradation of more polar shorterchain eg c6 pfas as well as pfas more recently introduced by the industry preliminary experiments performed in the host group demonstrate that graphene sponge electrodes are capable of defluorinating pfas even in lowconductivity water given that they are electrochemically inert towards chloride thus effectively overcoming a major limitation of electrooxidation processes formation of toxic chlorinated byproducts the progress made in this project on the functionalization and tailoring of graphene sponge electrodes for pfas removal from water will enable a major leap towards a widescale implementation of electrochemical processes and allow treatment even of the complex brackish pfasladen waters the applicants background on target and nontargetunknown analysis of organic contaminants in wastewater using lchrms besides qsar tools for the identification of toxicity alerts and the host groups expertise on nanoelectrochemical system using lowcost reduced graphene oxide rgobased electrodes for water treatment will ensure the success of this project focus4pfas will strengthen the research on chemicalfree water treatment technology for complete defluorination of pfas including the very polar homologues and their removal from the contaminated water focus4pfas will provide new opportunities for decentralized wastewater treatment reuse and source control of contaminated waste streams
new prime editing and nonviral delivery strategies for gene therapy

genome editing technologies based on crisprcas systems allow targeted genomic modification with unprecedented precision and have emerged as powerful alternatives to the conventional gene therapy approaches for various human diseases with a series of clinical trials in progress however some crucial challenges remain to be addressed to enhance efficiency and safety and decrease costs of treatments current viralbased delivery systems are associated with high risk of toxicity and immunogenicity and remain highly expensive we will develop a new generation of nonviral delivery systems for gene editing tools based on the use of modified nanoparticles with humanderived protein moieties that will allow targeting the tissue and cells of interest in vivo with minimal adverse effects prime editors have raised exciting possibilities for doublestrand break free genome editing however a major limitation of current prime editors is highly variable efficiency both from one target to another and between cell types we will design and evaluate novel prime editor tools in order to both increase activity per se and overcome cellspecific limitationswe will test our approach on the hematopoietic system to treat sickle cell disease avoiding the challenges and risks of hematopoietic stem cell manipulation associated with current gene therapy approaches and thus providing a treatment much simpler safer and costeffective to implementour technological breakthroughs address two key obstacles in cell and gene therapy gene editing efficiency and systemic delivery the novel prime editors and targeted nanoparticles that we will engineer will be combined to make unprecedented offtheshelf recombinant biologics for gene therapy the versatility of the design of these novel recombinant biologics makes them suitable for the treatment of a vast majority of genetic diseases