Dragon09/odtu_chatbot huggingface dataset:
a sustainable small scale model for formulation absorption screening

in this project our aim is to validate a small scale absorption model for sustainable and animalfree screening of pharmaceutical formulations intended for oral use the model will use small volumes and low quantities of drugs and excipients contributing to the sustainable approach taken the advanced model will enable companies to early on identify the best formulation which enable and increase absorption after oral intake the model can replace animal models directing the research to few proofofconcept studies in vivo in higher preclinical species rather than making use of formulation screens in rodents and higher species hence our technology is a gamechanger in the drug development process and significantly contributing to the reduce and replace focus areas of the 3r principles the company has a strong scientific foundation and the key people of enphasys ab have extensive network with leading pharma and biotech companies as well as scientific key opinion leaders currently the company has validated its business with regard to our services to customers making use of prime examples from big pharma in this women tech eu project our aims are to explore a new small scale innovation building on the knowledge acquired on the patented technology own by enphasys ab here we will analyse the market value extend and validate our business plan including the new small scale innovation analyse the ip landscape for the new innovation and identify sustainable manufacturers preferably located in europe
boosting taltech capacity in reliable and efficient aichip design

building on taltechs expertise in the field of computer engineering and its highlevel capacity in the domain of diagnostics and testing of nanoelectronic systems this project aims at establishing in taltech with the strong support of the advanced partners the capacity to rdi a complete customised aichip design flow the research ambition of the taichip taltech aichip action is a leadingedge forwardthinking rd framework for reliable and resourceefficient custom aichips based on open hw architectures eg riscv nvdla open eda electronic design automation tools methodologies and implementation technologies satisfying the requirements of ai applications of tomorrow taichip project also allows building at taltech the necessary scientific knowledge research skills administrative and management skills as well as strengthening its advanced training and education capacity evenly related to the central goal are the additional measures that focus on building the supporting capacities as well as dissemination exploitation and communication and public policy focused activities
fast and versatile realtime balancing of electricity demand flexibility shaping a clean and levelled power grid in europe

our solution prepares the electricity grid for a 100 renewable future it manages the power consumption of connected electric devices in realtime to ensure that electricity supply and demand remain closely matched this is achieved by temporarily curtailing advancing or postponing the electricity usage of these devices depending on the availability of electricity in the grid importantly by using relatively simple and lowcost hardware to integrate the devices into a large network that is driven by our powerful cloudbased intelligent software platform our technology can costeffectively control large and diverse networks of electric devices even those with relatively low power consumption down to 10kw the owners of these electrical devices in turn get paid for contributing to grid stability as our solution will exist of a modular framework it allows rapid expansion to different flexibility products and adjustment to national technical and regulatory requirements in europe
era chair life sciences program to empower molecular and structural biology initiatives at upat

upat is the third largest university in greece and widely recognized as an excellent knowledge and research hub the upat departments of medicine and pharmacy reached their high standards by combining efforts of their cell biology biophysics and structural biology research teams in fact their broad set of stateoftheart equipment was recently combined into a national research infrastructure also operating albeit at modest level in european biomedical and structural biology initiativesthus far the huge research and innovation potential of these upat groups are not yet fully exploited the esperance project therefore aspires to expand and intensify their concerted actions by adding a parttime era chair holder this new group for integrative molecular biophysics and structural biology will glue together the current research and education environment by boosting collaborative science and providing synergy he will participate in training and be instrumental in developing upats national and international visibility by boosting translational research and open access opportunities for the upat research facilities to achieve such ambitious goals a very talented respected internationally operating greek biophysicist structural biologist and research facility architect from the netherlands cancer institute has been attracted supported by his skilled local staff he will participate in many activities to optimize local strategies for the upat research groups and infrastructure towards future sustainabilityesperance incorporates elaborate programs for training early career scientists for attracting funding and talent for collaborative actions with industry and for institutional restructuring the development and enhanced capacity for the upat equipment will form an example for other local and nationwide research infrastructures and extent upats excellence visibility and competitiveness to benefit greek research in the european research area
sustainable secure and competitive energy through scaling up advanced biofuel generation

europe is on an ambitious path to becoming climate neutral by 2050 aiming to cut 55 of greenhouse gas ghg emissions by 2030 transport is a sector where so far it has proved harder to reduce emissions while being one of the main energy users and source of emissions transport sectors such as aviation heavily depend on high energy density fuels for which sustainable biofuels are the best near term lowcarbon renewable alternative biofuel production based on algae is being considered as a main clean energy alternative and one of the most promising solutions however there are several challenges that hinder development and application of algaebased biofuel ranging across the entire value chain susteps main overall objective is to improve key knowledge identify systemic constraints and opportunities and propose solutions for the scaling up of a sustainable algaebased biofuel value chain it aims to contribute to costeffective and more sustainable largescale production of sustainable algaebased biofuels by developing and validating a biorefinery concept that efficiently produces sustainable biofuel from nonfoodfeed microalgae via co2 fixation from highemission facilities and through feeding on nutrientrich wastewater thereby minimising biomass production costs and utilising harmful co2 emitted from energyintensive activities the process will be coupled with green hydrogen to be used in upgrading of microalgaebased fuel and smart integration of processes that also produce valueadded chemicals valorising all side streams effectively based on international collaboration susteps will build a more efficient less costly co2tobiofuels process identifying systemic constraints opportunities and solutions for scaling up the value chain of algaebased sustainable biofuels which will support the development of best practices and concepts along the entire value chain and accelerate the scaleup of sustainable biofuels worldwide
quantum engineering of superconducting array detectors in lowlight applications

optical measurements are fundamental to experimental science and observations of nature at the single photon level superconducting nanowire singlephoton detectors snspds are wellestablished as the gold standard in measurement due to their nearunit efficiency negligible noise and ultrafast response building snspd arrays and simultaneously extracting intensity spectral and spatial resolution from a device at the single photon level will revolutionise astronomical measurements spectrometry in chemistry and life sciences and quantum imaging key to unlocking this potential is to marry concepts from detector tomography with robust highyield detector fabrication the integration of complementary optical technologies and low heatload scalable readout schemes quesadilla tackles these challenges headon with a series of experiments demonstrating the groundbreaking potential of quantum detector engineering in contrast to engineering quantum states of light for metrology quesadilla will shift that paradigm by engineering the quantum mechanical response of the detector itself quesadilla introduces the concepts of a modal decomposition of the positive operator valued measure povm and quantumenhanced povm engineering in lowlight applications to do so arrays of snspds in combination with lithographicallywritten etalons and dielectric coatings will be developed in concert with stateoftheart scalable approaches to large scale quantum tomography quesadilla will exceed the state of the art in many areas performing the first modal decomposition of detector tomography and the largest tomographic reconstruction of a quantum detector the first demonstration of quantum detector engineering using nonclassical ancilla states the first demonstration of etalon array reconstructive spectrometry with single photons and exploit the fastest electronic shutter speed of any optical sensor to enable the highest dynamic range detection of continuous illumination
deconstruction of complex crosslinking damage

cells are constantly challenged by complex crosslinking damage which is caused not only by endogenous metabolites such as reactive aldehydes but also by various exogenous sources while crosslinking damage to dna has been studied extensively almost all reactive agents act pleiotropically and also damage rna and proteins however due to the complexity of the damage it is difficult to determine which components of the damage are responsible for specific cellular outcomes therefore it is unknown how crosslinking damage to rna and proteins affects cellular homeostasis and how it is detected and resolvedhere i propose to exploit novel experimental model systems that deconstruct complex crosslinking damage into distinct toxic components i will combine metabolic labelling with photoactivatablecrosslinking approaches to mimic aldehydeinduced rna or protein damage in the absence of dna damage we will combine these model systems with genetic and proteomic approaches to define the molecular mechanisms that detect and resolve rnaprotein crosslinks and proteinprotein crosslinks to this end we will capitalize on preliminary work indicating the existence of an entirely uncharacterized translationcoupled quality control mechanism that ubiquitylates and degrades proteins crosslinked to mrna ultimately i will build on these mechanistic insights to explore the physiological role of rna and protein damage in 1 the response to endogenous formaldehyde generated during cellular differentiation and 2 the mechanismsofaction of chemotherapeutic crosslinkersmy work will provide a comprehensive view on how complex crosslinking damage affects cellular homeostasis and will challenge the current paradigm that dna damage is solely responsible for the cytotoxicity of crosslinking agents as such my work will address a major blind spot in the fields of cellular quality control and genome stability with wideranging implications for cancer therapy and ageing
a drug screen for enhancers of adult neurogenesis in ageing drosophila as a new translationallyrelevant platform

ensuring a healthy lifespan in an increasingly ageing society represents a priority and a challenge for research and innovation particularly irreversible neurodegenerative conditions are becoming hallmarks in the elderly imposing a severe socioeconomic burden and ultimately threatening quality of life promoting adult neurogenesis has the potential to rejuvenate neural circuits restoring cognitive functions highthroughput models of adult neurogenesis can expedite the identification of mechanisms and compounds for the development of neuroregenerative therapies i have evidence for physiologic and druginduced adult neurogenesis in the genetically conserved and highly tractable model drosophila melanogaster here i aim to i characterize adult neurogenesis across drosophilas lifespan ii identify drugs promoting neurogenesis in ageing in vivo using the drosophila olfactory circuit as an experimental platform iii test primary drug hits for their potential to promote neurogenesis on hipscnsc in vitro host ugoe de secondments mpice de weizmann il dzne de next during a nonacademic placement in a translational drug discovery company i aim to profile prioritized hits promoting neuronal regeneration ldc de my unique background in chemical engineering and biosciences will be pivotal to successfully complete this project by leveraging stateoftheart tools and support from experts in the field droscreeneuro represents an innovative ambitious and translationallyrelevant approach towards the development of regenerative therapies aimed at counteracting agerelated neurodegenerative diseases dissemination of results between specialized and general audiences will make science open to all ultimately exposure to highquality training in the academic and nonacademic sectors will substantially enhance my skills and career perspectives to conduct research in academia and industry to promote societys wellbeing
efficient and novel waste streams coprocessing to obtain biobased solutions for packaging and agricultural sectors

ellipse project will address the valorisation of two heterogeneous waste streams generated in significant amounts in europe slaughterhouse waste bellygrass and paper and pulp sludge to produce costefficient phas for agricultural and packaging sectors by the coprocessing with other organic waste streams such as glycerol from the biodiesel industry and sludge from the dairy industry the integration of these waste streams as biorefinery feedstocks will allow reducing the volumes of waste destined to landfill or anaerobic digestion opening new avenues for platform chemicals and bioplastics production while creating additional revenue for the related industries generating the waste with added advantages of water recycling decreased soil degradation groundwater pollution and methane emissionsthe selected ellipse feedstocks are locally available and renewable leading to close to 100 renewably sourced personal care packaging and agricultural products ellipse project will be able to cope with at least 100 tonnes of slaughterhouse waste and 20 tons of wastewater sludge derived from pulp and paper industry the ellipse technology will impact in the european bioeconomy by valorising 20000 tons of rumen content waste and 50000 tons of paper sludge per yearellipse has a multiactor approach including all the relevant actors in the biobased system from the waste stream production and management gg and hepa to technology developers aimplas univr cartif best and industrial actors both smes biot biomi zer0e hp and bigger companies bbepp nvmt plus the expertise of enco for the market development perspective zer0e will contribute with the enduser and consumers perspective so that all inputs from the relevant actors are taken into account
cap analogs with a photocleavable group as a general reagent to produce lightactivatable mrnas as tool for fundamental and medical research

messenger rnas mrnas have recently entered the stage as therapeutic modality examples are the mrnabased vaccines against infection by sarscov2 hundreds of research groups in academia and industry aim to better understand the multiplicity of the mrna technology and its possible applications however at present researchers are unable to control when and where the mrna is translated into proteins which then have a pharmacological effect this is a bottleneck that severely limits the research needed to further develop mrna as a therapeutic modalitywe present flashcaps the first applicable solution that allows mrna studies to be driven by light without altering the structure or sequence of the natural mrna light is an excellent external control element that can be applied with high precision in space and time and without interfering with cellular processes flashcaps prevent the translation of the mrna until activated by light flashcaps are compatible with all standard mrna production and application procedures and thus of interest to all research groups and companies working on mrna to date in this proof of concept we will determine the innovation potential of flashcaps with a team of highly qualified scientists and innovation managers technological research to ensure reproducibility stability scalability and quality of flashcaps will be performed userfriendly applicability of flashcaps is achieved through the involvement of betatesters innovation management research including market analyses data analytics and consumer interviews is conducted to define the potential customers and their needs to analyse the market potential and to investigate our competitors based on the research results and the agile exchange between the technological and innovation management research we will decide on the best way of knowledge transfer to make flashcaps available to the growing number of mrna researchers
endogenous retroelements as transcriptional parasites and modulators of host immunity

almost half of our genome is occupied by ancient viral sequences that can be mobilized under certain conditions and either jump or copy themselves from one location to another a group of these mobile genetic elements is called endogenous retroelements mobilization of retroelements like line1 has been shown to cause cancer via insertional mutagenesis in recent years line1 activation has also been associated with the development of inflammatory diseases and inflammationdriven ageing this means we collected substantial evidence that half of our genome can potentially make us sick nevertheless we keep replicating these sequences with every cell division at great energetic cost suggesting that keeping them provides an evolutionary advantage in my project i will investigate if sporadic retroelement transcription in healthy cells serves a physiological role in priming the immune system through the constant sensing of retroelementderived nucleic acids by intracellular nucleic acid sensors my team and i will investigate how retroelement transcription is regulated in response daily life stresses like virus infections or dna damage i propose that instead of regulating transcription themselves retroelements are largely regulated by canonical gene expression in mouse models we will investigate how retroelements are sensed by the innate immune system and if this has functional consequences for establishing protective and pathologic immunity furthermore we will investigate the exact molecular mechanism by which retroelementderived single stranded cdna activates the innate immune system which is currently not understood our project involves the development of a new deep sequencing workflow for identification of the genomic origin of retroelement transcripts and a new mouse model to study endogenous line1 elements in vivo i believe that my project can fundamentally change our view on the role of endogenous retroelements as modulators of host immunity
memory in times of crisis argentina spain and greece 1998 to now

metc examines how people in networked societies recall the recent past rep in times of economic recession through the lens of social media som it explores the connections between crises and memory politics by investigating facebook instagram and internet forums in argentina spain and greece asg three countries which transitioned to democracy between 1974 and 1982 and experienced optimism and prosperity in the proceeding years before they suffered from economic crises metc is a comparative interdisciplinary historical and digitalethnographic project which links two methods of digital ethnography invisible observation immersive cohabitation with oral history and intermedial and multimodal analysis the project aims to a analyse memories of the rep during crises in som in asg b employ its own som to trigger discussions on the relationships between the present and the rep on the basis of stimuli gathered through archival research c scrutinise the politics of these somdriven mnemonic communities through oral interviews from people engaged in the formation of the politics of digital collective memory in asg metc provides an adaptable model for how historians and media scholars can turn embarrassment in the face of the somdriven explosion of amateur historical storytelling on the web into a source of inspiration and a channel of communication among these two communities of scholars and the public drawing on the hosts interdisciplinary capacity and synergies with experts in asg metc promises to provide a bold academic and social impact in these ways a publication in journals and the delivery of a hybrid workshop and seminars b interaction with popular audiences through som a photo exhibition and open public speaking events organised with immigrants from asg in sweden ultimately metc will enable research on digital memory to be a vehicle for interaction between the academy and society through culture and education
laboratorybased imaging of microstructure in polymers

polymers are increasingly used as a lightweight and more sustainable alternative to traditional materials like steel however product developers are not using the polymer materials to their full potential since they dont fully trust the models of strength and longevity having information about the material properties in the bulk of the components during the product development stage will provide this trust based on decades of experience from xray characterization and instrumentation our team has developed an xray diffraction method to generate this bulk data for semicrystalline polymers through the erc poc project we will improve the technology by extending the measurement to 3d maps of the sample from the current 2d capability the increased time in 3d scans will be alleviated through the use of focusing optics to improve the effective opening angle from the xray generator and with energy resolving 2d detectors with optimized absorption efficiency in the used energy rangein the project we will furthermore implement the technology in the development process of already selected companies through proto sales of a minimum viable product the sales will be based on a business model of providing the information from diffraction measurement to the customer as a service rather than through a sale of hardware this business model lowers the barrier of entry both for the customers and for us as a startup the lower barrier will help us reach a broader market of sme producers of polymers and aid in the establishing the technology as a generally recognized technique