Dragon09/odtu_chatbot huggingface dataset:
jumbo phages in translational enzyme research

jumbo phages are large viruses of prokaryotes with 200 to 800 kilo basepair kb genomes well beyond the size of small phages that average around 50 kb while investigation of small phages over the last century has transformed fundamental and translational biosciences jumbo phages research is only in its infancy the majority of jumbo phage genes are uncharacterized and cannot be annotated by comparative genomics thus it is unknown how the genes function in jumbo phage biology importantly jumbo phages generally carry genes to take over their hosts transcriptional and translational machinery in addition to harboring factors that may modify and degrade nucleic acids many of the unannotated genes might have similar characteristics which could be exploited for translational enzyme research however those genes remain experimentally underexploredthe jupiter project tests the hypothesis that some of the uncharacterized genes have properties that affect their hosts transcriptional and translational machinery and that some of the gene products could modify or degrade nucleic acids using an innovative highthroughput in vitro characterization strategy i will experimentally annotate gene products of unknown function according to their ability to catalyze the abovementioned reactions known and novel jumbo phages will be isolated and characterized to expand our current knowledge of jumbo phage biology promising candidate factors will be characterized in vitro and in vivo to understand their function and to facilitate translational enzyme researchmy results will provide i an innovative method for experimental gene annotation unraveling new mechanisms in jumbo phage biology ii an expansion of the available jumbo phage diversity and iii detailed insights into the function of novel factors unlocking future translational applications in biotechnology
a 100 sustainable and infinitely scalable electrical energy storage system

aquabattery is a revolutionary battery storage technology that offers unlimited storage capacity inexpensive scaling and is 100 sustainable aquabattery is based on a simple principle input renewable energy store it in seawater then return electricity when there is energy demand the core innovation is the use of seawater as a sustainable safe and scalable energy storage medium this is enabled by the companys patented membrane stack technology that utilizes bipolar membrane electrodialysis and reverse electrodialysis for energy storage and discharge during the charging phase saltwater flows through the membrane stack and produces an acid and base stream that is stored in tanks during discharge the solutions flow back through the membrane stack to generate salt water and release energy with this disruptive solution aquabattery aims at revolutionizing the energy storage world fostering the growth of renewable energy technologies and stopping the use of toxic materials
the trail of sulphur from molecular clouds to life

sulphur is the tenth most abundant element in the universe and is known to play a significant role in biological systems moreover some sulphur compounds have been proposed as necessary catalysts to form amino acids in the interstellar medium however while the carbon and oxygen budgets have been extensively studied sulphur is the only element whose gasphase abundance is still uncertain by several orders of magnitude hindering the usage of elemental sulphur abundance as a reliable tool to probe planet formation this lack of information is due to the scarcity of observations specially in protoplanetary disks and the still large uncertainties in the sulphur chemical network this project takes a decisive step to fix our knowledge of the sulphur chemistry with an innovative methodology that rests on three pillars i to create an unprecedented database of high quality observations of sulphurbearing molecules which allows us to trace the sulphur content from the natal molecular clouds to protoplanetary disks observations of the awarded iram large program gems have already provided part of this database ii to perform ab initio calculations and laboratory experiments to estimate the key reaction rates that are needed to fix the sulphur network and make chemical models reliable now we know that the chemical composition of planetforming disks is to a large extent inherited from the earliest phases of star formation iii to perform bifluid gasdust 3d magnetohydrodynamics simulations with chemistry coupled chemomhd to follow the chemical evolution of the material from the natal cloud to the planetforming sites and hence to obtain accurate chemical predictions this can be extensively done by using artificial inteligence to reduce the computing time at the end this project will disentangle how sulphur was delivered to protoplanetary disks which is an essential step to understand planet formation and the emergence of life
shared heritage early modern colonial forts in the south china sea scs bordering communities

forts of the south china sea bordering countries built between the sixteenth and nineteenth centuries are a notable remain of the long and complex history of encounters and exchanges with european powers practically forgotten by scholars and local administrations it is time to enhance their value with a new discourse as a shared heritage between european and local communities this project aims to 1 show how the local practices in the south china sea bordering countries mingled with the european theory of fortifications 2 raise the value of the shared fort heritage to create joint forces to preserve it 3 digitalize forts to make them publicly available as captured memory of current state it is planned to begin with traditional methods of study among which are a historical analysis using archival documents and morphological analysis also the tls methods will be used for digitalization as it allows a continuous recording of objects with a high level of accuracy for further analysis and modeling then an entirely new interdisciplinary research methodology will be introduced namely the transcultural interpretation of shared heritage that involves hbim novel typomorphological analysis finite element analysis fea material analysis and statistics the main foreseen results are the change of societal views on colonial forts the new shared view on the valuable structures and their digitalization for universal public access during centuries to come
agile exploration and geomodelling for european critical raw materials

new environmental economic and societal requirements in the eus transition to a lowcarbon and digital economy call for innovative methods technologies and techniques to be developed and applied in mineral exploration to unlock the crm potential in europe agemera will conduct local stateofart geological and geophysical surveys over a total of 4700 km2 in order to detailly map crm resources in 6 eu countries and 1 third country zambia the geophysical field trial surveys will demonstrate three novel noninvasive survey methods at up to a trl5 based on remote sensing and related data analysis 1 passive seismic methods 2 multisensing drone system combining magnetic radiometric and electromagnetic sensing and 3 muonbased multidetector density detection system the project will use data from openaccess databases eg european geological data infrastructure egdi the data collected from the field by project geoscientists and various geophysical survey methods to refine and improve the genetic mineral system models of the various deposit types known to contain lithium cobalt molybdenum vanadium pgms niobium tantalum bauxite and ree the project will introduce the existing guidance for the application of unfc for mineral resources to the partner countries through stakeholders courses and public events the project will survey citizens in the project countries create a crm educational package targeting schools and universities publish an online crm serious game organise public events as well as online news flashes with the aim to reach 5000000 citizens by 2030 the project will create an openaccess softgis analysis and database on peoples social cultural environmental and economic concerns related to mining and mineral exploration these data enable the creation of socioeconomic potential maps to be used in parallel with the geological potential maps consequently ensuring a basis for socially accepted and sustainable mining
a strategic roadmap towards the next level of intelligent sustainable and humancentred smes

over the last ten years many efforts have been made to transfer industry 40 from research to practice recently great progress has been made to introduce also smes to the use of industry 40 the next big challenge for smes will be to implement the dual or twin transformation in sense of a digital transformation towards more intelligent manufacturing while tackling and accelerating the sustainability transformation to enhance economically socially and environmentally sustainable processes factories and value chains in this project we aim to take smes to this next level by developing a strategic roadmap for making them not only intelligent but also sustainable resilient and humancentric this next level of smes will be data and intelligencedriven thus using available data to acquire new knowledge and to apply it for optimization purposes using artificial intelligence in a secure way further a great attention is paid to how manufacturing and value chains in smes can become more circular green and resilient by considering ethical human and societal values for more sociocentred factories in this next level of sme 50 factories the human will play a much more important albeit changing role besides identifying emerging future work profiles and competencies of sme employees we will develop guidelines for rendering sme workplaces in industry more inclusive and diverse and for empowering them for increased wellbeing and attractiveness of sme jobs the main outcome of the project is to develop and propose a strategic guideline and roadmap that will facilitate smes in europe and worldwide to achieve the above mentioned goals to expand the impact and exploitation an sme 50 stakeholder training network will be build the applicability of the results and guidelines is ensured through a close collaboration with nonacademic partners smes in the partner network and the aim to validate the results through demonstrators and case study research
implementing cationic paths in aliphatic ch oxidation

finding new reaction paths and establishing new frontiers in ch bond oxidation represent breakthroughs in organic chemistry going beyond preliminary findings discovered by the fellow dr marco galeotti this project will focus on the unprecedented implementation of cationic paths in ch bond oxidation diverging from the ubiquitous radical paths the proposed objective represents a change of paradigm in ch functionalization from a mechanistic perspective and in a broad perspective in organic chemistry because it will deliver a novel methodology to access unique and intriguing cyclobutane structures by singlestep functionalization of aliphatic ch bonds these transformations will be carried with a view to sustainability through the employment of earth abundant 3d catalysts and an ecofriendly oxidant such as hydrogen peroxide this proposal will benefit from the accumulated wealth of experience of marco galeotti in organic chemistry and in the mechanistic aspects of the factors governing reactivity and selectivity on aliphatic ch bond functionalizations this in combination with the supervision of prof miquel costas an internationally recognized expert in the chemistry of biologically inspired oxidation catalysis applied to organic chemistry will offer the possibility to uncover valuable mechanistic insights of this new oxygenation pathway the proposed project will represent a milestone in synthetic organic chemistry because it will deliver a wide variety of stereo and enantioselective fourmembered carbocycles in the oxidation of cyclopropyl derivatives for a broad spectrum of aliphatic ch bonds this transformation will be also applied in latestage csp3h diversification of natural product and pharmaceutical by placing this proposal in the realm of societychanging outcomes
secondmodelocking for a universal materialprocessing laser

lasers are ubiquitously used to cut drill mark texture 3d print materials materialprocessing lasers remain divided into cw nanosecond and ultrafastpulsed each excelling and falling short differently cw lasers reach the highest powers cost the least and are far more common but cause heat damage and their utility is materialspecific ultrafast lasers achieve supreme precision on any material but remain niche as they are inefficient and expensive nanosecond lasers fall in between we propose to overcome this categorisation by inventing a universal laser that can process any material from metals to living tissue exceed the efficiency limit of equilibrium thermodynamics approach the quantum mechanical limit and surpass the speed of industrial cw lasers it will do so by taking our invention of ablationcooled lasermaterial removal nature 2016 to uncharted territory where electrons and atoms will be kept perpetually far from mutual equilibrium even between successive pulses the same laser will perform 3d printing or tissue welding by switching to quasicw operation to this end we need the unprecedented combination of 30fs pulses at 1kw average power and onthefly tunable repetition rates of 011 thz the latter implies an impossibly short laser cavity the alternative is to support multiple pulses in the same cavity but this has long suffered from poor performance due to fundamental reasons regular modelocking generates ultrashort pulses by locking cavity modes via nonlinear feedback but it has no mechanism to mutually lock multiple pulses we fill this conceptual gap by introducing a nonlinear time filter this innovation underlies the new laser concept of second modelocking which will create thousands of ultrafast pulses in perfect periodic arrangement to reach extreme repetition rates with a disruptive potential for not only material processing and laser surgery but also microwave thz generation beyond5g communications laser ranging
foodigit computational food science and digital transformation era chair programme

the eu agrifood industry is facing major challenges related to food security safety and sustainability european ri actors can significantly contribute to addressing these challenges and support competiveness of eu food sector the aristotle university of thessaloniki auth the largest university in greece is widely recognised as an excellent food science ri centre a swot analysis reveals that due to the fragmentation of food research across different schools the huge ri potential of auth is not yet fully exploited hampering progress in research excellence and talent attractiveness in line with the new era for research and innovation the european green deal and the eu4digital strategy at the heart of this proposal is the ambitious vision to establish the computational food science and digital transformation foodigit centre at auth under the guidance of a distinguished era chair foodigit aims to bridge food science across auth and ri excellence by integrating current food research with data science cuttingedge digital tools and information technology it solutions this integration will attract toptier talents and act as a transformative force boosting research and infrastructure synergy across auth the foodigit centre is also poised to be a cornerstone for reshaping the relationship between academia and society through the creation of foodigiteco a new innovation and knowledge transfer ecosystem based on an extensive partnership network with ri organisations food industry federations regulatorscompetent authorities and consumer associations foodigiteco will transfer cuttingedge research results and knowledge from academia to the food industry but also act as a conduit for industry needs identifying challenges and requirements directly from the food sector and integrating them into auths education programme overall foodigit will enhance auths visibility and competitiveness in the european research area
preventing groundwater contamination related to global and climate chanpreventing groundwater contamination related to global and climate change through a holistic approach on managed aquifer recharge

the impact climate and global change cc and gc is endangering human health food security and biodiversity urgent action is needed to achieve 2030 zero pollution goalsmar2protect will provide a holistic approach to prevent groundwater gw contamination from gc and cc impacts based on a newgeneration managed aquifer recharge mar the core of the innovative mar is the mair dss that will incorporate technological and societal engagement information using an aibased evaluation to improve gw quality to ensure a high replication potential mair dss will collect information from 5 demo sites in eu pt it es nl and 2 in noneu countries tn za which were carefully chosen by their degree of maturity from previous successful projects and a wide range of settings in terms of climatic conditions water sources type of pollution mar scheme and politicalsocietal context all technologies will be tested and validated until trl5 mar2protect will ensure a strong engagement of civil society in gw prevention actions up to a srl equal to 6 the project will involve national and eu policy makers that in collaboration with a community of practice formed by worldwide experts will guarantee the strengthening eu policy for the prevention of gw contaminationthanks to its holistic approach and to the high replicability of its results mar2protect will lead to a marked enhancement in gw protection across the eu and beyond and to the generation of knowledge for the transition to a sustainable water management the consortium includes 8 partners and 1 affiliated entity from 6 different eucountries and switzerland and 2 international partners from tunisia and south africa 2 universities unibo ktu 7 rtos novacoo ciimar cetand aqua ihe it issbat suwi and 1 association feuga in addition the inclusion of 3 large water utilities as associated partners and a policy maker from za will lead to a relevant enhancement of the project impact
new isotope tracers of rocky planet forming environments

the plethora of earthlike exoplanets indicate that planetformation is efficient highlighting the need for unravelling the pathways to forming habitable worlds the new planetformation paradigm ie pebble accretion suggests that mmtocm sized pebbles are the main planetary building blocks as opposed to colliding protoplanetary bodies bulk samples of meteorites from asteroids leftovers from the early solar system have been long used to infer the nature of earths precursor material however pebble accretion predicts that pebblelike components of primitive chondrite meteorites provide a more accurate record of the precursor material to terrestrial planets including the source of volatiles critical to life the most abundant chondrite constituents are mmsized chondrules hypothesized to be the pebbles driving planet formation chondrules formed within 5 myr of the solar system thus represent timesequenced samples that can probe the nature of the matter including its environments that accreted to rocky planets we will elucidate the origin and history of the matter precursor to terrestrial planets by studying chondrules matrix and refractory components in chondrites this information is key for understanding the initial conditions allowing the formation of earthlike planets combining isotope fingerprinting agedating and petrology our data will be obtained using stateoftheart techniques including next generation collision cell and thermal ionization mass spectrometry as well as highresolution imaging we will identify the precursor matter to terrestrial planets and probe how its composition varied in space and time identify the disk environment where the primordial population of planetesimals seeds formed and evaluate the role of thermal processing and outward recycling in modifying inner disk matter with these goals including highrisk highgain ventures we are in a strong position to make step change discoveries in cosmochemistry
enhancing efficiency and effectiveness in education

highquality education is a key driver of economic growth and social progress despite large investments in education over the past few decades the quality of education in some eu countries has stagnated or even deteriorated marginalized populations are particularly vulnerable to the negative consequences arising from inadequate educational policies understanding the efficiency and costeffectiveness of investment in quality education is crucial for allocating resources to where they could have the largest economic and social impacts the effect research project has been established as an impactdriven initiative that aims to provide evidencebased policy recommendations to improve the quality of education by investigating the effectiveness and efficiency of education systems and specific policies in eu countries by using quasiexperimental evidence effect advances knowledge in several critical areas including diversity equity and inclusion teachers trainers and digital transition instruction and adultlearning effect has four interrelated objectives objective 1 offers novel insights on diversity equity and inclusion by investigating targeted programs for disadvantaged students as well as religious and elite schools objective 2 investigates how teacher shortages can be mitigated and examines the role of digital environments objective 3 evaluates policies related to instruction admission standards and upskilling and reskilling of adults finally objective 4 analyzes how the efficiency of eu educational systems has changed since the covid19 pandemic and establishes the main policy levers and qualitative insights that may explain efficiency changes effect brings together a multidisciplinary research team of economists sociologists neuropsychologists teacher trainers education scientists mathematicians and sustainability and operational research experts from four european research universities a research institute and a ngo