Dragon09/odtu_chatbot huggingface dataset:
advancing safe and sustainable by design practices in pharmaceutical manufacturing

pharmeco is supported by the innovative health initiative joint undertaking ihi ju the ju receives support from the european unions horizon europe research and innovation programme and cocir efpia europa bo medtech europe and vaccines europe the projects overall objective is to revolutionize pharmaceutical manufacturing towards sustainability by integrating environmentally friendly technologiesprocesses and harmonized sustainability assessments methods into healthcare industry practices this encompasses early design phase operation and eventual use and disposal the projects first objective is to enhance the earlystage development of pharmaceutical products by implementing sustainablebydesign ssbddriven processintensified platforms eg continuous manufacturing this involves designing sustainable processes based on socalled select safety environment legal economy control and throughput criteria and setting up ecofriendly systems for producing small molecules peptides oligonucleotides proteins and ribonucleic acid rna with advanced control measures next pharmeco aims to scale up and demonstrate environmentallyfriendly processes for industrial manufacturing and decontamination which includes creating infrastructure for studying key unit operations with sustainable technology and for ssbddriven process intensified manufacture at a scale sufficient for clinical testing and a manufacturing process that is easily transferred to a good manufacturing practice gmp environment pharmeco also aims to steer the development of biomanufacturing processes towards sustainable production through digital decisionmaking tools this involves creating a modular digital tool for assessing sustainability from multiple perspectives evaluating practices finally the project seeks to establish a standardized approach for assessing the environmental sustainability of pharmaceuticals which involves collaboration with various stakeholders to create scientifically robust guidelines applying consistent life cycle assessment lca methodologies and facilitate regulatory adoption of standardized lca practices by integrating sustainability considerations into every phase of manufacturing pharmeco will positively revolutionize pharmaceutical industry
somatostatin receptor inhibitors for sustaining muscle and bone mass following pharmacologically induced weight loss

obesity affects 1 in 6 adults in europe driving demand for therapy agonists of the glucagon like peptide 1 receptor glp1ras such as semaglutide novo nordisk and tirzepatide eli lilly have led to substantial weight loss in millions of patients however a large fraction of lost weight is attributed to loss of lean mass muscle and bone a reduction in lean mass increases the risk for sarcopenia and osteoporosis loss of muscle and bone our analysis of 748667 patients using glp1ras has shown that most are women over the age of 50 a population already at risk for muscle and bone loss sarcopenia and osteoporosis cause pain fatigue limit the ability of patients to perform daily activities and increase their risk for fractures with millions of glp1ra users and an annual direct cost of 5000usdosteoporosis patient loss of lean mass can cost billions to health care systemsgrowth hormone gh is the natural signal in adults for sustaining lean mass results from our erc project identified pathways that may sustain gh signaling during and after weight loss we propose to develop novel molecules that will lead to an increase in natural gh secretion we will test the efficacy and safety of a library molecules we designed for their ability to maintain lean mass during glp1rainduced weight loss the results will secure the intellectual property surrounding the novel molecules and their useby addressing the underlying causes of muscle and bone loss we aim to develop a comprehensive solution to the obesity crisis our innovative biochemical approach targets the aging population struggling with obesity and has the potential to prevent disease in millions of patients and alleviate a significant burden from healthcare systems
active producttoprocess learning for improving critical components performance

the manufacture sector is and will continue experiencing an evolving trend marked by the exponential growth of additive manufacturing the ongoing 4th industrial revolution industry 40 and an increasing demand of customization of the manufactured products however the production and economical growth of the manufacturing sector needs to meet unpostponable sustainability guidelines and criteria already in 2010 the international energy agency identified the critical areas that should lead to the undelayable reduction of c02 emissions by 2050 the area that will have the largest impact is the socalled enduse energy efficiency sector directly linked to the manufacture sector where the aim is doing more with less this means minimizing the energy losses as much as possible to be ready for the upcoming challenge there is a need to create a critical mass of highly skilled young engineers and innovators who will enhance europes position in the engineering sciences specifically these future engineers and innovators need to get familiar with two key technical challenges within the manufacturing sector the uncertainty induced by the production process eg human errors geometrical and material variabilities caused by the manufacturing process andor by the machine setup and the increasing complexity of the manufactured goods characterized by the critical parts or componentsthe ambition of the active producttoprocess learning for improving critical components performance apriori training network is to train the next generation of doctoral candidates dcs to fully sustain the ongoing transition of the eu manufacturing sector this will be achieved by developing the skills and new technologies that will enable for the first time the development of a unique integrated product design strategy that will drastically improve the performance of critical parts or components under uncertainties
smart ultraviolet radiation filters

over 3m new cases of skin cancer occur annually with 85 related to sun exposure hence widely preventable sunscreens are key players for skin cancer prevention protecting us from the uvr due to their active ingredients uv filters regrettably existing filters have limitations fast degradation toxic to humanssea environment limited exposure time require combination of multiple filters for full uv spectrum protection roka furadada has developed and patented smart uv overcoming all those limitations nontoxic longlasting uvrdose dependent and eco sustainable lignin as raw material promoting circular economy our goal is to make smart uv the first choice for sunscreen manufacturers and users that wish to protect their skin without harming the environment the eic acc will help bring smart uv to market optimizing scalability sustainable synthesis completing lab tests and obtaining cosmetic ingredient certifications roka expects to breakeven by 2024 with sales of 4m
extreme analytics for mining data spaces

exa4mind will build an extreme data platform that brings together large scale data storage systems and powerful computing infrastructures by implementing novel automated data management and effective data staging this will enable integration with extreme data sources and support complex and advanced data analysis pipelines for knowledge extraction involving three large universities and a research centre small and mediumsized enterprises smes and the industrial sector exa4mind uses interdisciplinary toplevel expertise to create a modular extreme data database edd analytics environment driven by four representative extreme data application cases from the fields of molecular dynamics autonomous driving smart agriviticulture and healthsocial big data exa4mind will support data ingestion and versatile preprocessing develop an advanced query and indexing system with convenient interfaces and leverage highperformance storage and computing infrastructure we will make big data from heterogeneous storage systems and database management systems available in a uniform way for processing on european preexascale supercomputers cloud and aiprocessing systems further to providing automatised staging caching or direct access to these systems the results and relevant data from our project will be made available to the european fair data ecosystem including european data spaces eudat and the eosc therefore standardised modules and automated procedures will be implemented in our edd the project will constitute a leap forward towards common european big and extreme data techniques in science industry and smes offering advanced data workflow orchestration the edd will be validated proven and sustained in collaboration with application partners generating internationally recognised results exa4mind will thus lay the technological foundations for future european data analytics and computation taking into account the whole digital continuum
zoonoses emergence across degraded and restored forest ecosystems

ecosystem degradation and biodiversity loss may facilitate the emergence of zoonotic diseases the 4year zoe project will analyze the links between landcover and land use changes in tropical biodiversity hotspots facing loss of primary forest and biodiversity and in temperate regions that have undergone ecosystem degradation and deforestation over historical timescales in areas experiencing different levels of ecosystem degradation biodiversity assessments will be based on remote sensingbased gis analysis of landscape structures geobotanic plant mapping and targeted trapping of rodents ticks and mosquitoes as prototypic reservoirs and vectors of zoonotic diseases macroorganism scale host and soilassociated microbiome and virome highthroughput sequencing will be combined with assessment of human exposure to prototypic zoonotic pathogens using highthroughput serological analyses microbiological scale zoe will link with local communities and stakeholders to address perceived land use and land cover changes disease occurrence coping strategies and risk behaviour results will be synthesized in modelling and risk mapping frameworks linking biodiversity loss and zoonotic disease risks and tested in forecasting scenarios to feed into costefficient monitoring schemes and early warning systems an online knowledge platform will be created to link all relevant stakeholders of the biodiversityhealth nexus including other eufunded consortia national and supranational organizations stakeholders local communities and the public a joint stakeholder conference will be organized and community engagement workshops will specifically cocreate and advance knowledge in local communities involved in zoe the zoe project is proposed by an interdisciplinary consortium with expertise in geography geobotanics ecology virology immunology epidemiology sociology psychology anthropology and science dissemination from 7 eu and 4 american countries
brain20 a paradigm shift in acute ischemic stroke ais patient management

acute ischemic stroke ais represents 85 of strokes and is the 2nd leading cause of death and the leading cause of disability worldwide today ais patient management lies on imaging tools multimodal ctmri and scores to select patients for endovascular treatment evt the gold standard still its efficacy is limited to 46 due to the lack of tools to guide decisionmaking brain20 is a noninvasive medical device class iib that provides realtime monitoring of ais patients brain viability thereby predicting who will benefit from evt time is brain has the exclusive right to the ipr of a neurophysiological biomarker n20 a sep and surrogate of cerebral blood flow tib aims to implement the clinical trials to validate brain20 acquire cemark and fda clearance and bring it to market by providing realtime and continuous monitoring of brain viability brain20 will accelerate stroke management and predict evt outcome and offer tailored care for each patient
the possibility of artificial life at subzero temperatures the role of water in cellmimicking compartments

in the last few decades researchers have come to believe that where there is liquid water there is life regardless of the physical conditions of the surroundings indeed living organisms have been discovered in environments with extreme temperatures radiation or high salinity in terms of temperature the lowest limit to sustain the metabolic activities of bacteria is reported to be 20 c in permafrost yet the survival mechanism of life below the freezing point of water is still not fully understood though it has important implications for origin of life studies and the search for life in the universethe prerequisite of life at subzero temperatures is the existence of liquid water intracellular liquid water not only serves as solution medium but also plays a crucial role in biological processes such as metabolisms in cells therefore understanding the physical state of intracellular water at subzero temperatures is important in artwater we will employ synthetic compartments as model system to investigate the physical state of compartmentalized water at subzero temperatures the project will be conducted through a bottomup approach from pure water in compartments to crowded compartmentalized solutions that mimic cytoplasm in natural cells the crystallization diffusion and dynamics of water will be studied by differential scanning calorimetry nuclear magnetic resonance and broadband dielectric spectroscopy respectively several types of stateoftheart synthetic compartments will be employed including polymersomes liposomes and complex coacervates furthermore we will develop artificial cells equipped with liquid water enabling biological activities at subzero temperatures the artwater project will not only open the window for understanding the survival mechanisms at extremely low temperatures but also provide a new platform for tunable bioengineering processes such as cryopreservation and cryoenzymology and shed light to astrobiology
cell factory on chips make cell therapies affordable and accessible to all patients

sarcura gmbh an austrian deeptech company founded in november 2019 will develop and market a machine platform for the industrial gmp manufacturing of personalised cell therapeutics such as cart therapieswe will contribute to scale the global cell therapy manufacturing capacity of these lifesaving treatments from currently thousands of doses per year to hundreds of thousands of doses cost effective and safe for all patients sarcura envisions to transform existing manufacturing paradigms by using leadingedge semiconductor technologies such as integrated photonics embedded in microfluidic liquid processing systems to bring bioprocess control to cellular levelwe believe that only by bringing together automation integration of additional functionality miniaturization and modularity we can achieve the required 100fold increase in manufacturing capacity the cell therapy industry requires our initial focus is the development of a gmp ready fully automated industrial cell isolation device for the manufacturing of cell therapies the device will include all necessary processing steps to handle the typical starting material of clinical cell therapy as well as provide integrated process analytics and quality control such as cell count viability phenotype characterization and other analyticsafter launching the first single unit operation device for the cell isolation further devices performing the formulation gene transfer and expansion followed by an integrated endtoend device will be developed finally we aim to market an autonomous selfoptimising manufacturing system based on realtime manufacturing optimisation via ai driven artificial intelligence predictive process controlour product offer will include a desktop instruments b singleuse microfluidic cartridges and c software and algorithms
momentum premium postdoctoral fellowship

the momentum premium postdoctoral fellowship programme momentum ppdf has the ambitious goal to attract 35 highquality postdoctoral fellows in two subsequent calls to the research performing host institutions and research groups of hungarys most prestigious pi focused research grant the momentum programme managed by the secretariat of the hungarian academy of sciences mta secretariatthe pis and research groups of the momentum programme represent the best selection of emerging talents in hungary in all research fields and offer a great opportunity for the msca fellows to engage in their research at the forefront of science in a research environment committed to scientific excellence with the support of the msca cofund programme this widely acknowledged flagship scheme in hungary will be further elevated by increasing its international visibility enhancing its european and global outreach and improving interdisciplinary and intersectoral collaboration dimensions the momentum ppdf will play a catalytic role in the creation of a vivid ecosystem comprising momentum research groups and their academic and nonacademic partners in hungary and abroad by promoting networking and inspiring new interdisciplinary cooperations with a potential to achieve breakthrough scientific resultsthe postdoctoral fellows supported under momentum ppdf will not only benefit from researchrelated trainings but will also acquire knowledge from a wide range of courses to develop key transferable skills and competences essential for the development of their career a particular emphasis will be placed on exploiting the potential of networking between the momentum host organizations and associated partners from academia and industry by encouraging new collaborative approaches we aim to foster joint initiatives spanning various disciplines embracing not only interdisciplinary endeavours but also promoting extensive intersectoral and international cooperation
new implicitsurface finite element methods to discover universal mechanisms of animal embryo development

all living organisms emerge from a single cell the zygote in early embryo development of animals the interplay of cell surface dynamics polarity proteins and intracellular flows forms distinct polarity domains which the cell uses to specify the fate of its daughter cells a classical biological model to learn how animal cells polarise is the 1mm long c elegans roundworm establishment of cell polarity in the c elegans zygote is well studied yet the biophysical mechanisms controlling cell polarity beyond that stage remain largely unexplored biophysical experiments and finite element fe models could together elucidate this matter however fe models of multicellular morphogenesis other than rare rely on explicit surface descriptions explicit methods are not ideal to simulate cell polarity at the multicellular scale because they can hardly deal simultaneously with 3d foamlike geometries coupled surfacebulk physics and topology changes conversely fe methods based on implicit surfaces have recently shown convincing potential to bypass this weakness in this project i will launch a new implicitsurface fe paradigm to simulate early embryo development and i will apply it to gain new insights on the patterning of c elegans embryos to this end i will pioneer implicitsurface fe methods for coupled surfacebulk dynamics in foamlike geometries the success of the project is ensured by joining leading expertise in implicitsurface fes from myself biophysics of morphogenesis from my supervisor and patterning in c elegans embryos from my external collaborator i will be based at the center for interdisciplinary research in biology of the cnrs located at collge de france a unique and ideal place to create new synergies between a fe researcher like me biophysicists and cell biologists as well as to grow and diversify my scientific and transferrable skills to become one of the few independent leaders in fes for multicellular morphogenesis in europe
scribal understandings of norse eddic metres

old norse poetry particularly the corpus of narrative and gnomic verse known as eddic poetry forms one of the richest contributions from scandinavia to the literary heritage of europe this poetic corpus survives only through a chain of manuscript copies which separate our extant texts from the original compositions the aim of sunem is to investigate the changing understandings of metrical forms possessed by the scribes who copied and recopied eddic poetry specifically the project will create digital texts and metrical annotations of the poems in one particular source hervarar saga and use the various surviving manuscripts of this work 14th17th centuries as a testcase to evaluate scribal engagement with metrical norms during the late norse and early modern periods these poems are in three different alliterative metres each of which shows specific rules concerning features such as syllable weight or the placement of unstressed syllables as scribes make changes to the texts they copy they are sometimes careful to continue to adhere to these rules and sometimes disregard them sunem will investigate these patterns of change with respect to these rules in order to assess copyists varied understandings of and commtiments to older rules of eddic metres these models of how scribes copied eddic texts and conceived of the poetic forms they reproduced will be of practical use to future editors of norse poetry extend our understandings of traditional norse metres beyond the classical norse period and provide new perspectives on the transmission of verse
new copernicus capability for trophic ocean networks

the oceans biodiversity supports the livelihoods of over three billion people providing vital services including food and nutrient cycling however marine policy and resource management do not yet consider the latest scientific advances even when the stateoftheart operational models of the european copernicus marine service cmems are usedour objective is to enable cmems to deliver novel products that inform marine biodiversity conservation and food resources management by fusing new data into innovative ecosystem models that integrate biological and abiotic components habitats and stressors of marine ecosystemsneccton will interlink new models in the cmems systems thus building novel capacities to simulate highertrophiclevels benthic habitats pollutants and deliver projections of climate change impacts we will develop and exploit new dataprocessing chains supporting cmems use of novel ecosystem observations including new hyperspectral data from satellites as well as available acoustic pollution and omics data we will fuse these new data and models by using innovative machinelearning algorithms to improve models and data assimilation methods these developments will be applied in thirteen case studies codesigned with fisheries and conservation managers as part of our pathwaytoimpact resulting in the demonstration of technological readiness level 6 of neccton productsthe project objectives will be achieved by a team of twentythree worldclass organizations with track records for all the key project components it includes the cmems entrusted entity and core developers who will promote the final uptake of neccton by cmemson project completion neccton will provide cmems with the scientific and technical capabilities to sustain twentyfive new products in their operational portfolio ultimately enabling users to make informed decisions on the exploitation of marine services enhancing sustainability and conservation