Dragon09/odtu_chatbot huggingface dataset:
clinical validation of artificial intelligence for providing a personalized motor clinical profile assessment and rehabilitation of upper limb in children with unilateral cerebral palsy

unilateral cerebral palsy ucp is the most common neurological chronic disease in childhood with a significant burden on children their families and health care system aincp aims to develop evidencebased clinical decision support tools dst for personalized functional diagnosis upper limb upl assessment and homebased intervention for children with ucp by developing testing and validating trustworthy artificial intelligence ai and costeffective strategies the aincp approach will i establish a clinical diagnosis and accurate prognosis for treatment response of individual ucp profiles by employing a multimodal approach including clinical phenotyping advanced brain imaging and reallife monitoring of upl function and ii provide personalized homebased treatment from advanced ict and ai technologies the aincp will build upon personalized diagnostic and rehabilitative dst ddst and rdst to be developed and validated through large observational and rehabilitation studies including at least 200 and 150 children with ucp respectively using data driven and ai approach ddst and rdst will be combined for developing a theranostic dst tdst that will allow the redesigning of an economical ethical sustainable decisionmaking process for delivering a personalized and validated approach focused on the care monitoring and rehabilitation of upl in children with ucp aincp is a significant example of a transdisciplinary approach where all project collaborators clinicians data scientists physicists engineers economists ethicists smes children and parent associations will work closely together in building the aincp approach this approach will therefore hinge on transdisciplinary contributions multidimensional data sets of innovative devices and fair aibased algorithms clinically effective and able to reduce users and market barriers of acceptability reimbursability and adoption of the proposed solution
building a european community of practice of hubs for circularity

h4c europe project will create a european community of practice ecop it will provide a community knowledge platform and exchange structures that will help the existing and future hubs in creation management and growth by overcoming barriers to isiusc the ecop is set up to be selfsustaining 10 existing hubs have committed to join as ecop founding members the ecop will preserve the findings of isiusc research and innovation projects especially those funded by the ec and member states it will organize a continuous exchange of ideas and best practices and facilitate indepth exchanges between experts to identify bottlenecks evaluate the outcomes of related projects and propose innovative approaches to overcome bottlenecks possible topics include the financing and operation of is infrastructures matching demand and supply in is and ius sharing benefits crossborder exchange of materials water and wastewater systems regulatory issues in the use of secondary raw materials the tension between reuse and use of waste as feedstock to name a few digitalization is a transversal enabling aspect of isiusc and the usage of digital tools will be an important aspect of each expert group in line with the call and to achieve its vision the csa will work along four axes 1 sustainable community building and establishment of an it knowledge platform as a tool 2 consolidation and creation of available knowledge by analysis of the state of the art indepth discussions of leading experts and field trials of business models and financial strategies ao for largescale demonstrators 3 development of a kpi toolkit for the assessment of the maturity of isiusc regional initiatives towards h4c and independent evaluation of h4cs as candidates for lighthouse projects as well as the elaboration of policy recommendations 4 promotion of the h4c concept societal engagement and policy recommendations
novel design of offshore wind farms by employing highfidelity computations to mitigate their acoustic impact on marine life

whalenoise emerges as a timely and essential initiative born from a dual sense of purpose driven by two pressing concerns firstly with the urgent need to achieve ambitious targets in clean energy generation the european union set forth its 2020 strategy on offshore renewable energy aiming for a remarkable 300 gw of offshore wind capacity in response to this accelerated timeline the development of offshore wind technology has seen rapid advancements to meet the escalating demand for clean energy secondly over the past 20 years the world has witnessed a remarkable surge in awareness regarding acoustic pollution in the oceans this awareness is evident through the increasing number of scientific publications on the subject and the implementation of new regulations aimed at protecting the hearing thresholds of marine animals two commonly cited problems with respect to marine renewable devices are collision risk and noise impact the former is concerned with marine life being unable to determine the locations of devices also known as the masking problem and may be alleviated by introducing specially designed warning devices the latter regards the damaging effect of acoustics generated by the turbine on marine animals eg noise masking communication between individuals and can be reduced only via a redesign of energy farms whalenoise aligns with these environmental imperatives as it addresses both challenges in a synergistic manner its core mission is to understand and predict the acoustic emissions from offshore wind farms fixed and floating seeking to evaluate their detrimental impact on marine life by striking this delicate balance between clean energy generation and ecological conservation whalenoise promises to contribute significantly to a sustainable and harmonious future for our oceans and the life they nurture
holographic assembler for 3d cell cultures

cell cultures are essential for biomedical research and drug screening the environment and the arrangement directly affect cell function it has become clear that biological cells behave differently when cultured on a surface as opposed to a 3d environment this discrepancy between 2d in vitro studies and the 3d environment found in vivo is critical for cancer research most notably patientspecific therapy and highthroughput drug screening and discovery almost 90 of all drug candidates fail during the trial phases and one of the main reasons identified is the low physiological relevance of 2d cell cultures technologies are needed that enable the fast and efficient culturing of 3d cell assemblies with high repeatability and control over size and morphology here we use our recently developed technology and fabrication knowhow together with the expertise from our ercfunded research to realize the first 3d bioassembler where the shape of the cell aggregates can be precisely defined by the user within this ercpoc grant we plan to develop a fully operational standalone benchtop bioassembler that instantly aggregates biological cells spheroids particles or hydrogel capsules into fully defined 3d structures using acoustic holography our device will be an easytouse and affordable instrument that is fully compatible with established biological procedures and laboratory equipment and which allows scientists to culture the specific cell structures they need the grant will allow us to protect our knowhow identify further markets and develop a commercialization strategy for our technology overall this project will generate the first 3d cell assembler that permits the generation of userdefined cell spheroids and custom shapes at a press of button and thus presents an innovation with a sizeable market potential
fast electrooptic fluorescence lifetime microscopy eoflim for superresolution microscopy and brain surgery

fluorescence lifetime imaging microscopy flim is a powerful method for monitoring physicochemical parameters of cells and tissues as well as biomolecular interactions with applications in science medicine and industry however its use is currently limited due to technological constraints regarding frame rate and sensitivitywe have developed a flim detector that enables highly sensitive highspeed flim it is based on the use of electrooptical elements as temporal gating units electrooptical flim eoflim enables frame rates beyond 100 hz for megapixel images singlemolecule sensitivity and highresolution imaging numerical aperture 13we will demonstrate the innovation potential of our detector in two key applications superresolution flim and surgical flim superresolution flim will be done in collaboration with prof huser univ of bielefeld we will apply our eoflim detector to superresolution microscopy at high frame rates in live cells and tissues surgical flim will be done in collaboration with prof unterhuber medical univ of vienna and will aim at diagnosing cancerous tissue in brain biopsies superresolution flim and surgical flim will demonstrate the wide applicability of eoflim in research and medicine
rebuilding the foundations of planet formation protoplanetary disc evolution

with thousands of exoplanets known we have truly entered the exoplanet era explaining the huge diversity of observed exoplanetary systems remains however a big challenge the only way we have to study planet formation is to study the environments in which they form protoplanetary discs to understand planets we have to understand discs and the physical processes happening in themthe field of protoplanetary discs is currently being shaken by the crumbling of viscous theory the traditional paradigm used to describe how discs evolve in time the paradigm relied on the presence of turbulence which affects a myriad of processes of planet formation the crumbling of viscous theory thus has ramifications across our entire understanding of planet formationhow can we rebuild the foundations of planet formation thanks to advances in observational capabilities we can now perform large surveys of protoplanetary discs and study the evolution of their properties mass radius mass accretion rate over the last few years i played a leading role in showing how to use this information to guide and constrain models of disc evolution computing quantities from the models that can be directly compared to observationsbuilding on my expertise at the convergence of theory and observations i propose a to develop quantitative models of an alternative paradigm of disc evolution in which discs evolve under the influence of disc winds rather than viscously the longlasting impact of discevol will be to deliver a new standard model of disc evolution tested against the existing data from observational surveys discevol will also b reassess how crucial steps of the planet formation process such as the accretion of solids onto growing planetary cores and planetary migration differ in a disc evolving under the influence of winds altogether this program will bring the link between models and observations of planet formation in discs to a new level
multiscale modelling of aberrant phase transitions in biocondensates

the spatiotemporal organization of the cell material represents one of the great wonders in physics chemistry and biology compartmentalization plays a key role in such precise molecular coordination and enables cellular function over the past decade transformative experiments have revealed that most intracellular compartments are not enclosed by membranes but instead they are dynamical assemblies termed condensates and thought to occur via liquidliquid phase separation of biomolecules nevertheless the misregulation of these condensatesmostly formed by proteins and nucleic acidscan give rise to deleterious solidlike aggregates which are associated with the proliferation of agerelated and neurodegenerative disordersinphase aims to develop an innovative computational approach to resolve the dynamical behaviour of molecules inside functional condensates that drift their complex physicochemical behaviour into pathological solid aggregates to this end we plan to develop a multiscale modelling platformcombining coarsegrained force fields and atomistic simulationswhich will address the following critical questions what are the encoded molecular features in rna and protein sequences regulating phase behaviour what pushes biomolecular condensates to shift their material properties over time can we prevent the proliferation of pathological aggregates induced by condensate misregulation the overarching goals of this project are 1 to understand the thermodynamic and intermolecular forces driving condensates outoffunction and 2 devise potential strategies for preventing rnaprotein aberrant phase transitions in biomolecular condensates this alone is groundbreaking because it will reveal the underlying mechanisms and interactions by which the structure and sequence of rna and proteins dictate the material properties of intracellular condensates and their implication in cellular dysfunction
magnetic energy conversion for waste heat

the production and use of energy account for more than 75 of the eus greenhouse gas emissions decarbonising the eus energy system is therefore critical to reach our 2030 climate objectives and the eus longterm strategy of achieving carbon neutrality by 2050 obviously solar and wind power will play an important role in any future energy scenario but such intermittent sources present significant challenges in energy transport and storage at the same time a vast amount of lowgrade heat is generated eg in datacentres food pulp and paper industries and is available 247 even converting only a small percentage of this heat into electricity is significant due to the sheer amount of heat wasted just above ambient temperature however efficient technologies to convert this lowgrade heat in an economically sound way are lacking within this project we will develop thermomagnetic harvesting from current trl 34 proofs of principle to an efficient and cost competitive trl 67 technology our interdisciplinary consortium of 9 academic institutes and 4 industrial partners address all major challenges for this emerging technology which requires innovative designs of more efficient thermomagnetic generators that are intimately connected with tailored thermomagnetic materials our team consists of engineers who invented thermomagnetic systems at various sizes and power ranges materials scientists with ample experience in advanced magnetic materials bulk or film preparation and characterization and physicists who cover modelling from the ab initio scale via micromagnetism at the mesoscale up to the macroscopic device scale this rich multidisciplinary environment will allow training of 10 young professionals by crossfertilization with fresh ideas they will obtain the interdisciplinary competence required to bring this green technology to a mature level and career perspectives in both the academic and nonacademic sectors delivering the green deal
cryptogam biodiversity dynamics under climate change in the arctic and antarctic poles

earths polar regions are warming at unprecedented rates antarctica is experiencing rapid regional warming and the arctic has warmed up to four times the global average in response vascular plants have experienced shifts in species abundance and distribution polar regions host large richness of cryptogam species bryophytes and lichens which are essential ecosystem regulators that contribute to nutrient cycling soil moisture and energy balance despite these crucial roles and expectations that cryptogams can be seriously affected by climate change taxonomical challenges hinder our understanding of their current trends bipolar will tackle this knowledge gap by quantifying polar cryptogams climatic niches to understand their potential for climate change adaptation both poles contain similar habitats shaped by extreme conditions but the arctic is warming more rapidly than antarctica and ecological processes have been more extensively documented there bipolar is an interdisciplinary project that will provide a window into the future of antarctic cryptogams by using the arctic as a sentinel region via bipolar cryptogam species ie present at the two poles bipolar will combine a variety of methods and data ie palaeoecology openaccess datasets fieldwork and bayesian statistics and employ historical and current data to inform future projections the three objectives of bipolar are 1 compiling and standardising bipolar cryptogam data from multiple sources 2 quantifying past present and future macro and microclimatic niches and identifying winner and loser cryptogam species and 3 validating species occurrence and climate data through fieldwork this research will provide a foundation for conservation as these regions become progressively more ice and snowfree while strengthening currently fragmented arctic and antarctic research links and bringing together the polar research community
minimum environmental impact ultraefficient cores for aircraft propulsion

building a sustainable and climate neutral future for aviation is an inevitable requirement for a society with increasing mobility needs if we are to stabilise the global temperature below the 15c threshold set by the paris agreement rapid action is to be taken minimal will contribute to a radical transformation in air transport by providing disruptive ultraefficient and lowemission technologies that will in combination with the aviation ecosystem sustainably reduce the climate impact of aviation the minimal project will through an unprecedented effort between european engine oems world leading atmospheric physics scientists and lead researchers in combustion and propulsion attack the major sources of nonco2 and co2 emissions in aeroengines this will be accomplished with the introduction of climate optimised new propulsion systems based on composite cycle engine technology that provides unparalleled flexibility with respect to operations and that has the potential to eliminate the large sources of effective radiative forcing by 2035 80 reduction from contrails 52 reduction from netnox and 36 fuel burn reduction resulting in 36 to 100 co2 reduction depending on the fuel usedresults will allow assessing the interdependencies between nonco2 and co2 effects already during the early stages of aerothermalmechanical design and converge into engine options that have minimum climate impact the findings are supported by numerical trl 2 and experimental trl 3 proof of concept of lownox opposedpiston constant volume combustion technology with premicromixing of hydrogen in minimal we understand the urgency and aim for maximum impact aggressive but realistic roadmaps will be outlined together with regular exchanges in major industry research centres to develop these technologies into products and bring them to in 20352040
noninvasive conduction velocity mapping in brain networks a novel imaging framework for axonal fingerprinting of brain connections in health and disease

axonal bundles in cerebral white matter form the structural basis of functional brain networks enabling effective integration of neural activity the axonal connections are not homogenous structures axons differ in diameter and myelination enabling signal conduction at different velocities this axonal diversity is a clinically relevant microstructural feature as neurodegenerative or neuroinflammatory processes can affect axon diameters differently recent advances in magnetic resonance imaging mri have enabled the noninvasive mapping of the microstructural properties of brain network connections in live brains but attempts to correlate these structural features with brain function have not yet been successful i have pioneered the mapping of axon diameters that are directly linked to the conductive properties of axonal connections by using diffusion mri in living human brain also i have established an unique crossdisciplinary validation setup for such methods by combining nanoscopic 3d synchrotron radiation imaging and functional cellspecific targeting techniques by conduction velocity mapping in brain networks combrain i will be able to unravel the altered functional dynamics of the microstructural connections in the diseased brain methodologically i will push the frontiers of mri by creating a new translational combrain framework for noninvasive and invivo studies in animals and humans clinically combrain will provide a new window into the characterization of neuropathological changes in the diseased brain and contribute to the identification of structurefunction fingerprints of psychiatric and neurodegenerative disorders that are thought to be a major pathogenic factor in many brain diseases
druggability of gquadruplexes promising modulators for antimicrobial resistance

the antimicrobial resistance amr is an underrated problem promoted by widespread misuse and massive use of antibiotics thus the health systems are facing enormous costs to treat nosocomial infections due to amr bacteria in particular six highly virulent bacteria eskape are the main responsible for worldwide nosocomial infections in the last years our research strategies to discover and develop new clinically relevant antibiotics lacked effectiveness as a result we are unable to efficiently treat amr infections and are unprepared to face an amr bacteria outbreak one possible strategy is to target bacteria gquadruplexes bgqs which are highly conserved dnarna secondary structures pivotal for bacteria duplication transcription and translation this strategy is particular effective because when a new pathogen emerges its dnarna genome is first disclosed through sequencing hence the ability of quickly designing new drug candidates based only on this information will be a powerful tool to face a new epidemicpandemic furthermore the human gqs hgqs were largely investigated as possible target for anticancer treatment thus the interest in bgqs raised later and with less intensity than hgqs in addition most gqs modulators bind gquartets top by stacking interactions and the druggability of gqs loopsgrooves was still not addressed in this context the multidisciplinary of gqreat eskape project aims to provide a novel and effective strategy to contrast amr by targeting bgqs and to expand the knowledge on bgqs