Dragon09/odtu_chatbot huggingface dataset:
science and innovation to empower eu industrial resilience and economic security

the european union eu is actively pursuing a rapid shift towards environmentally sustainable lifestyles and economies this green transition is designed to promote sustainability address climate change and combat environmental degradation european industry plays a pivotal role in this twin digital and green transition the main objective of this proposal is to contribute to ri policies that will strengthen european industrial leadership and economic security our proposal aims to make indtech24 a forum bringing together all stakeholders to exchange around specific ri and policy challenges and stimulate networking an overarching question we would like to address is how rd policies could be better integrated to recent ambitious european initiatives to make sure the future of our industry is made in europe innovative materials are key to achieve the ambitious policy objectives of the european green deal taking place following the release of the coordinated action plan with member on advanced materials indtech24 will fall within a context of intense reflection on the ri priorities and specific objectives we will address ri challenges and opportunities in innovative materials showcasing best practices will be done by involving stakeholders from various kind to gather good examples and shed light on success stories following the objectives of the step initiative we aim to engage discussion on the ways we could build more bridges between different instruments horizon europe cluster calls and partnerships erdf ipceis to avoid the duplication of investments and contribute to reducing the fragmentation of the ri landscape in the eu we will also discuss policies that could unlock the innovation potential of european smes notably from lessons learned from the implementation of oitb for material science the final outcome of these sessions will feed into a ri and policy recommendations for eu member states and the european commission
highpower hydrogen fuel cell system balance of plant component upscale and optimization

proton exchange membrane fuel cells are considered as one of the solutions enabling longterm sustainable transport however incumbent systems provide electric power outputs below 200 kw to cater to the need of the heavyduty transport sectors the development of next generation of fuel cell systems aims at durable pemfc stacks offering power output between 250 and 500 kw to support this development the h2upscale project aims to design build test and validate key bop components for pemfc systems generating more than 250 kw electric power suitable for heavyduty transport applications aviation maritime onroad longhaulh2upscale brings together 3 research organisations 2 academic and 11 industrial partners including bop manufacturers and oems the project will identify applicationspecific requirements that will then drive the requirements development and optimization of 3 standards for modular and scalable pemfc architectures 250kw electrical power supply architectures waste heat management system designsthe bop components in focus include the hydrogen ejector h2 recirculation pump h2 leakage sensor air compressor cathode air filter and air humidifier water separator exhaust resonator coolant heat exchanger and coolant medium the targeted advancements for bop components include efficiency and durability improvements weight and volume reduction and architecture simplification the components will be designed to be compatible with both single and multistack platforms with scalability and modularity in mind facilitating their integration into multimw scale systems selected fullscale bop components will be validated on a hardwareintheloop test bench and a technoeconomic analysis of the potential impact of the developed bop components on the hd markets will be performed with these main targets the aim for h2upscale is to provide critical technological bricks enabling the creation of a trl7 demonstrator from 2027 onwards
catalytic atroposelective synthesis for revealing elusive bioactive conformations and shapes

atropisomeric molecules atropisomers are separable conformational isomers arising from restricted rotation around a single bond atropisomers have revolutionized the treatment of several deadly diseases the principal goal of atropshape is to create pharmaceutical leads with unusual conformations and shapes by developing catalytic stereoselective atroposelective synthesis methods toward difficulttoaccess druglike atropisomers because atropisomers are chiral they give rise to two or more isomers that have different pharmacological properties these attributes relate to a crucial yet minimally investigated and poorly understood fundamental question of how conformational changes from achiral and relatively planar to chiral and more tridimensional atropisomeric forms impact a molecules ability to interact with biological receptors but to study such range of atropisomers and related concepts one must first of all create them therefore i will introduce three new catalytic atroposelective methods 1 we will develop unprecedented atroposelective amidebond formations and apply them to synthesis of the first examples of peptidomimetics with an atropisomeric amide moiety 2 we will efficiently generate by alkyne cyclization strategies sphereshaped atropisomers this rarely investigated area of molecular shape is much soughtafter in drug discovery 3 we will introduce the first instances of atroposelective decarboxylation of esters the proposed methods will offer direct access to an assortment of bioactive atropisomers which will be easily modifiable to generate by diversityoriented synthesis approaches libraries of druglike molecules which will be tested broadly in medicinal chemistry collectively the resulting knowledge will shed light on key differences between pharmacological properties of achiral compounds and chiral atropisomeric molecules constituting an invaluable insight for drug discovery and development
a post growth deal

how can we sustain human wellbeing within planetary boundaries what policies and provisioning systems could enable societies to prosper without growth what politics and alliances are necessary for seeing postgrowth policies through and how can the public be engaged in them what new scientific paradigm could answer such questions societies face multiple intertwined crises bold alternatives are sorely needed this project develops frameworks for postgrowth deals from empirical research through to practical applications first we develop equitable northsouth convergence scenarios modelling human wellbeing achievement in all countries within planetary boundaries second we articulate postgrowth policy packages for the global north and south assessing their political acceptability and modelling their effects third we develop models of provisioning systems to ensure future populations have adequate energy food shelter health and social security fourth we learn from political movements studying politics and alliances that could bring postgrowth transitions forward fifth we identify practical steps to bring postgrowth deals to life working with four representative communities to coproduce knowledge and action on the groundthe potential gains of this research are immense postgrowth transitions may unlock a far more ecologically stable and socially prosperous future than current trajectories lead to real brings a paradigm shift moving postgrowth science from economics to sustainability studies we propose a new transdisciplinary 5ps of postgrowth science grounded in resourceenergy modelling politicaleconomy and sociopolitical analysis a skillset that no single researcher or team presently possesses the pis are leaders in their fields and bring complementary expertise in modelling of provisioning systems jst political economy and northsouth relations j and the politics of socioenvironmental transformations gk
lymphoid organoids to study immune synapse in lymphoma therapies

diffuse large bcell lymphoma dlbcl is the most common type of nonhodgkin lymphoma nhl in europe and worldwide with more than 463100 000year activated b cell abcdlbcl represents the more aggressive and chemoresistant subtype to the frontline therapy rituximab rchop doxorubicin vincristine prednisone mechlorethamine with 40 of patients experiencing no response or relapse therefore new treatments are needed to improve the clinical outcome of abcdlbcls a newly defined characteristic feature of the abcdlbcl subtype is the concurrent constitutive activation of b cell receptor bcr and tolllike receptor tlr pathways that result in the upregulation of the nfb through cooperative signaling in abcdlbcls the nfb signal is mediated from the downstream regulator mucosaassociated lymphoid tissue lymphoma translocation protein 1malt1 paracaspase that is upregulated in 70 of these tumors for this reason malt1 paracaspase has become an attractive therapeutic target and malt1 inhibitors have been developed however previous studies indicate that approximately 63 of patients respond to bcr pathway inhibitors and therefore understanding factors such as the intricate survival signals imparted by the lymph node tumor microenvironment lymphtme in abcdlbcl is critical for clinical translation of malt1 inhibitors two key elements of the lymphtme are the infiltration of t helper cell th and the activation of ecm mediated pathways the aim of loise project is to establish an ex vivo organoids that will mimic the t immunological synapse and ecm features with the purpose to elucidate their role on abcdlbcl survival and signaling response to bcr pathway inhibitors these organoids will be used to designed a combinatorial targeted therapy for abcdlbcl
breaking the barrier an integrated multidisciplinary approach to kill gramnegative bacteria through existing antibiotics by making their outer membrane permeable

antimicrobial resistance which is caused by multidrugresistant bacterial pathogens is a global health emergency gramnegative bacteria gnb notably hinder effective treatment because of their impermeable outer membrane om consequently many standardofcare soc antibiotics cannot access intracellular targets in gnb the objective of the breakthrough european training network etn is to sensitise gnb to these antibiotics by making their om permeable to this end we will develop inhibitors of three protein machineries that are responsible for om maintenance importantly many known antibacterial agents have characteristics different from drugs that are directed against targets in mammalian cells to define better rules for antibacterial drug development a data hub will be created to assemble information on the physicochemical characteristics of molecules that can pass the omto achieve these goals a multidisciplinary academicindustrial consortium has been assembled with organic chemists computational chemists and specialists in highthroughput drug screening zebrafish infection models bacterial morphogenesis and the molecular biology of the three targets the expected outcomes of the breakthrough etn include i the development of new chemical space rules for drugs that need to cross the om ii the discovery of new inhibitors that interfere with om maintenance to overcome the insensitivity of gramnegative pathogenic bacteria towards soc antibiotics and iii providing 10 early stage researchers with scientific technical business and transferable skills to become professional drug developers with a keen eye for the hurdles in the development of these drugs in an industrial context
maximizing the use of a first clinically viable myc inhibitor

even though the myc oncogene is a mostwanted target in cancer therapy no myc inhibitor has yet reached clinical approval the applicant has developed omomyc the first mycinhibiting miniprotein to have successfully completed a phase ia clinical trial the goal of this proposal is to maximise the use of this compound as both a therapeutic and study tool opening new lines of research in different aspects of myc biologyto start with since omomyc cannot efficiently cross the blood brain barrier excluding it from use in brain malignancies or brain metastases in aim 1 we propose to validate its efficacy when delivered intracranially by different means including osmotic pumps and hydrogels as well as to test its delivery by intracarotid injection in glioblastoma and brain metastasesthen in aim 2 and 3 we will explore its combination with personalized medicine namely parpi and krasi respectively these 2 aims are derived from two pillars of myc biology its role in dna damage response and the paradigm of oncogene cooperation aim 2 will allow us to shed light on the role of myc in homologous recombination and resistance to parpi while aim 3 will deliver on the molecular mechanisms underlying the cooperation of ras and myc in multiple tumour types where their combined inhibition could represent an unprecedented therapeutic opportunityfinally aim 4 will focus on the characterisation of cancers such as small cell lung cancer and gastrointestinal stromal tumours that have the peculiarity of being defective for max mycs natural partner but that recapitulate a mycdependent tumour phenotype likely driven by other members of the myc network whose function could also be hindered by omomyc treatmentnotably each of the aims explores new aspects of myc biology tracing new lines of research around the most deregulated oncogene in human tumours as well as having immediate translational applicability in upcoming clinical trials of omomyc
ferrimagnet powered memristors for neuromorphic computing

neuromorphic computing nc represents a groundbreaking approach to computation drawing inspiration from the human brain to enhance power and efficiency compared to traditional computing methods however to achieve even greater efficiency nc requires hardware that also mimics the behavior of neurons and synapses memristive synapses are pivotal components in emulating the synaptic plasticity observed in biological neural networks nevertheless the implementation of spintronic memristors compatible with stateoftheart computing is challenging due to the large current density needed the long switching times present in ferromagnets and the need of small applied magnetic fields the objective of this project is then to design fabricate and characterize fieldfree memristive synapses using gdbased ferrimagnets we will use two approaches alloptical magnetic switching and the use of multiferroics to switch the magnetization by the application of electric fields by taking advantage of the unique properties of ferrimagnets ultrafast and energy efficient magnetic switching we aim to develop highly efficient synapses that exhibit memristive behavior without the need for an external magnetic field
advancing fertility and reproduction through dedicated and innovative technological applications

the development of assisted reproductive technologies art has provided an alternative for people with difficulties conceiving naturally and over 9 million babies have been born through art since 1978 moreover the use of art has increased dramatically 53fold during the last two decades and this trend will continue while art have undoubtedly made a positive impact on the lives of couples and individuals dealing with infertility numerous studies reported potentially negative artderived effects on the health of offspring the mechanisms involved and their consequences are poorly understood and there are critical unanswered questions including whether the manipulations and the artificial environments in which gametes and embryos are cultured or the increased paternal and maternal age at the time when the treatments are applied entail artderived health risks thus there is a growing need to advance research on art consequences and propose holistic solutions as well as to develop innovative training programmes to prepare new researchers to deal with such concerns the afrodita advancing fertility and reproduction through dedicated and innovative technological applications consortium takes up this challenge and aims to implement jointly an innovative international multisectorial and multidisciplinary research and training programme joint doctorate by bringing together key scientific staff from the academia 5 european universities and 3 excellent research centres the largest hospital in denmark and the corporate world 8 enterprises with a history of fruitful collaboration that will guarantee excellent training and effective supervision for afroditas 15 doctoral candidates to enhance their career opportunities for different professional paths
photoassisted light alkanes dehydrogenation to olefines under mild conditions with trimetallic clusters confined in zrbased mofs as the catalyst

light olefins have been considered fundamental feedstocks in the chemical industry for decades current industrial processes for the synthesis of light olefins include naphtha cracking and light alkane dehydrogenation in thermochemical processes are under harsh conditions and therefore energyintensive in the last decade the solartochemicals conversion process has attracted great attention as it is deemed that the utilization of solar energy for the replacement of traditional fossil fuels is an ideal solution to the energy crisis and global warming however even though several reaction processes have been extensively studied and progress has been achieved such as photocatalytic water splitting and photothermalphotocatalytic co2 reduction lightassisted alkane dehydrogenation reactions for the sustainable production of alkenes has not been explored yet the objective of this research proposal is twofold 1 developing new catalyst based on trimetallic clusters confined in zrbased mofs tmcmof for the photoassisted light alkane dehydrogenation under mild conditions 150oc and 2 understanding the mechanism of the photoassisted process providing principles for design more efficient catalysts the present project represents a significant step forward by showing the applicability of the solarassisted alkane dehydrogenation process presenting a significant advantage in terms of co2footprint
german arithmetical treatises in manuscripts of the late middle ages 14001522 a study on philology history and culture based on a digital edition of the treatises

how was the practice of arithmetic developed and spread during the transition between the middle ages and the modern period we know a lot about the evolution of mathematical theory and its diffusion in latin but little about the way in which arithmetic knowledge spread in the vernaculars in the 15th and early 16th centuries translation and adaptation of arithmetic treatises and manuals provided access to mathematical knowledge for new groups of people shaped the practices of reckoning and opened new ways of teaching arithmetic skills to persons without higher education these efforts also endowed european vernaculars with new linguistic forms of abstraction and thus enhanced their potential to serve as a tool in the modern scientific revolution arithmetic will study handwritten german arithmetic treatises from their first appearance around 1400 until the time when printed reckoningbooks became easily available at the beginning of the 16th century these texts have not been studied before although they are important witnesses of the vernacularization of mathematical knowledge of the interdependence of vernacular and latin pragmatic literacy and of the links between mathematics sciences and commerce the treatises will be transcribed digitally edited and analyzed from a historic literary and linguistic perspective an assertive edition relying on semantic enrichment will be one product of arithmetic a detailed linguistic analysis focusing on semantics syntax the vocabulary and the transmission context will lead to the reconstruction of an arithmetic discourse give information on the orality underlying didactic texts and allow tracing writerscompilers and users and their educational and social background this research aims at a new understanding of how arithmetical knowledge and practices of calculation were transformed in late medieval europe and how an abstract and scientific language emerged in the german vernacular
advanced research on viroid pathogenesis and control for agricultural sustainability

viroids the smallest infectious pathogens cause crop losses in the millions of euros every year and affect crop yields and quality worldwide climate change allows viroids to invade new geographical areas and hosts posing a threat to global food security viroidoc is an international multidisciplinary and crosssectoral phd network that aims to thoroughly understand and tackle viroids in line with the european green deal and the farmtofork strategy for sustainable crop production and food security to achieve this viroidoc will i fill knowledge gaps in molecular pathogenesis and host interactions of viroids ii assess the impact of climate change on viroid infection iii characterize emerging viroids and viroidlike rnas in plants and fungi iii develop innovative crisprcas and sensorbased diagnostics for early detection of viroid infections and iv provide viroid interventions including breeding targets antiviroidal agents and rnabased biopesticides viroidocs mission is to prepare 10 doctoral students dcs for careers in molecular biology bioinformatics research product and service development in european agriculture and innovation development the viroidoc consortium composed of researchers with complementary expertise in basic research molecular biology biotechnology genetics bioinformatics applied sciences nano and sensor technologies and innovation development plant protection plant diagnostics plant breeding will provide dcs with excellent scientific methodological and soft skills exposure to an international environment and different industries will allow them to build a valuable network of contacts providing a solid foundation for future research collaborations and direct employment opportunities finally viroidoc will contribute to european research excellence foster technology transfer and raise awareness of viroid issues thus improving food safety and the sustainability of agriculture in europe and beyond