Dragon09/odtu_chatbot huggingface dataset:
demonstrating a hydrogenpowered gasturbine engine fuelled with up to 100 h2 hypowergt

the hypowergt project aims at moving technological frontiers to enable gas turbines to operate on hydrogen without dilution the core technology is a novel drylow emission combustion technology dle h2 capable of handling mixtures of natural gas and hydrogen with concentrations up to 100 h2 the combustion technology has been successfully validated at trl5 early 2021 retrofitted on the combustion system of a 13 mwe industrial gas turbine novalt12 besides ensuring low emissions and high efficiency the dle h2 combustion technology offers fuel flexibility and response capability on a par with modern gasturbine engines fired with natural gasthe new technology will be fully retrofittable to existing gas turbines thereby providing opportunities for refurbishing existing assets in industry chp and offering new capacities in the power sector for load levelling the grid system unregulated power and for mechanical drives the dle h2 technology adheres to the strictest specifications for fuel flexibility nox emissions rampup rate and safety stated in the strategic research and innovation agenda 20212027 system prototype the new dle h2 combustion technology will be further refined and matured and towards the end of the project demonstrated at trl7 on a 169 mwe gasturbine engine novalt16 fired with fuel blends mixed with hydrogen from 0100 h2 within this wide range emphasis is placed on meeting preset targets for a fuel flexibility and handling capabilities b concentration of hydrogen fuel during the startup phase c ability to operate at varying hydrogen contents d minimum ramp speed and e safety aspects pertaining to any level with regard to related systems and applications targeting industrial gasturbine engines in the 1020 mwe class a digital twin will be developed to simulate performance and durability characteristics emulating cyclic operations of a real cogeneration plant in the italian paper industry
targeting eicosanoid metabolism to overcome tumor immunosuppression

the field of cancer immunotherapy has witnessed exciting therapeutic advances in the last decade but still a large fraction of patients is not responsive and several cancer types are refractory to this therapy the presence of a strongly immunosuppressive environment is a likely explanation for the suboptimal efficacy of immunotherapy one of the most abundant and immune suppressive population in the tumor microenvironment tme is represented by tumorassociated macrophages tams therefore several strategies that sculpt the tam phenotype away from their immunosuppressive state are expected to become the next generation immunotherapies supported by the erc consolidator grant immunofit we recently unveiled that the metabolic editing of the tme via the pharmacological and genetic inhibition of hpgds in macrophages an enzyme involved in the production of prostaglandin d2 from arachidonic acid represents a novel therapeutic strategy to sculpt tams away from their immunosuppressive state increase infiltration and fitness of cd8 t cells and nk cells and promote tumor vessel normalization this change in the tme upon hpgds inhibition overcomes resistance to current immunotherapeutic regimens in melanoma and other cancer indications this proposal aims to derisk hpgds targeting by delivering a lead compound with proven efficacy in several preclinical models the deliverables of this project will openup a window of opportunities in immuneoncology and lead to novel combination therapies by increasing the potency of the current therapeutic approaches
the role of transposable elements in human brain evolution

the human brain is the largest and most complex of all primates possessing unique cognitive functions but also suffering from neurological disorders however little is known about primate brain development and the modifications enabling brain enlargement as primate tissues are not available at early developmental time points only few changes occurred in proteincoding genes thus significant differences must be present in gene regulatory processes it is essential to analyse primate models to identify and understand molecular features unique to the human braintransposable elements tes are mobile pieces of dna comprising 50 of primate genomes they can contribute to genome evolution as they carry regulatory sequences and have been found to serve for example as enhancers and alternative promoters moreover tes are insertional mutagens leading to genetic disease they are silenced by repressive marks including dna methylation interestingly methylation can sometimes spread and impact adjacent regions making tes noteworthy candidates for methylome evolution due to their challenging analysis and lack of primate material the role of tes in primate brain development and human brain evolution has not been investigated thoroughlyhere i propose that humanspecific te insertions have the capacity to act as repressors and silence genes in brain development exploiting human and nonhuman primate cerebral organoids as a model for brain development and oxford nanopore technologies longread dna sequencing to detect dna methylation i will analyse locusspecific te methylation spread to nearby genes using differential expression analysis and crisprcas9 genome editing i will assess the effect of putative repressor tes on gene expression revealing if the repression of specific loci contributed to human brain enlargement and gain of cognitive functions
3d printed membrane and bioremediation for the reduction of per and polyfluoroalkyl substances pollution in aquatic ecosystems

the presence of per and polyfluoroalkyl substances pfas in water bodies has adverse impacts on human health and ecosystems and is one of the main concerns regarding the eu green economys growth based on zero pollution because pfas can resist conventional water treatment processes it is essential to develop alternative technologies based on advanced materials for their complete mineralization into co2 and h2oamong several approaches photocatalysis using nanoparticles can degrade many recalcitrant pollutants but presents a lower capacity for their mineralization and a timeconsuming and expensive recovery process of particles in contrast bioremediation has successfully achieved the defluorination of some pfas compounds but it is a relatively slow processin this context this proposal intends to apply 3d printing technology to produce novel and reusable multilayered polymer membranes incorporating photocatalysts and then develop a forefront hybrid water treatment technology combining for the first time photocatalysis and bioremediation to solve the urgent environmental threat ensuring the effective degradation and maximum mineralization of pfas in different aquatic matriceshence this project aligns with the european green deal 2030 agenda and eu missions to reach a nontoxic environment it will be completed in multidisciplinary research environments such as nanotechnology additive manufacturing photochemistry and environmental biotechnology using interdisciplinary efforts to engineer a revolutionary environmental remediation technology the applicant brings photochemistry environmental and materials science knowledge to the research group and will acquire expertise in 3d printing technology bioremediation and ecotoxicity the proposed work will expand the applicants experience competencies and professional networks enhancing her career development as an independent environmental remediation researcher
cooperation and agreements enhancing global interoperability for aerosol cloud and trace gas research infrastructures

the goal of cargoact is to deliver a clear roadmap for sustainable global cooperation between keygroundbased aerosol cloud and trace gas research infrastructures each having invested in infrastructure and services to support their observing networks with a longterm perspective with a view to consolidating into a sustainable global research infrastructure in the future there is a strong desire for global integration from the research community including weather climate and air quality monitoring and modelling and in particular from space agencies since global networks of groundbased observations are an essential component complementing earth observation from space providing calibration and validation of the remote sensing information collected by current and future satellite missions the integration of the current groundbased networks which may have different interests and priorities requires cooperation and agreements at the global level including engagement with relevant stakeholders their service provision is not limited to data services but includes access to the measurement facilities reference instruments reference standards and laboratories all of which are topics to be assessed in cargoact the specific objectives of cargoact are to develop sustainable partnerships and decision making processes with relevant partners demonstrate the benefits of converging interoperability and standards to stakeholders and the global research community establish the mechanisms for providing international access to distributed research infrastructures and develop a roadmap for upscaling towards an integrated global research infrastructure for aerosol cloud and trace gases
design protonconducting metal organic frameworks based membranes for proton exchange membrane fuel cell applications

proton exchange membrane fuel cells pemfcs converting chemical fuels into electricity are a promising electrochemical technology for the sustainable energy production using clean energy sources thus addressing the global challenge of energy demand and pollution control however drawbacks of the current polymer electrolyte materials ie degradation and efficiency limit their application metalorganic frameworks mofs a class of hybrid porous materials have recently found potential applicability in this emerging crossdisciplinary energy area mofpems project aims to prepare new cost effective mofbased membranes gathering good stability and high proton conductivity over wide range of humidity and temperature conditions supported by theoretical calculations toward understanding their protonconducting pathways which is an important step to industrially efficient pemfcs mofpems will thus overtake the current bottleneck of most commercial pems by developing new electrolyte materials with high proton conductivity comparable or even surpassing nafion and affordable price filling the gap between basic research and marketable applications key opportunities envisioned from mofpems include mitigation co2 emissions and alternative sustainable energyconversion and energy storage systems that are reliable lowcost and environmentally friendly we believe that the results of mofpems will attract large industrial interest derived by the need of society and governments for continued energy supply associated with rapid population growth
measuring uspace social and environmental impact

the goal of muse is to develop a set of key performance indicators methods and tools for the comprehensive and rigorous assessment of the impact of uam operations on the liveability and quality of life in european cities with particular focus on dronegenerated noise and visual pollution this general goal translates into the following specific objectives1 to define a set of uspace social and environmental kpis able to capture the full range of uams impacts on citizens quality of life with the highest possible level of geographical temporal demographic socioeconomic and behavioural resolution2 to develop new methods and tools for the measurement and forecasting of the proposed kpis the new toolset will provide accurate drone 4d trajectory generation in urban areas modelling of uams noise and visual footprints highresolution dynamic population mapping and calculation of population exposure indicators segmented by type of day and time of the day citizens sociodemographic profile type of activity being performed and other relevant variables3 to showcase and evaluate the capabilities of the new methods and tools developed by muse through their application to a set of case studies in one or more european cities4 to create the conditions for the transfer of the project results to the subsequent stages of the ri cycle by outlining a new sesar solution the muse uspace environmental and social impact assessment framework that serves as an enabler of a future uspace service aimed at optimising the social and environmental performance of uam operations
evaluation of the icleareu intervention to integrate palliative care in the treatment of people with advanced copd and their family caregivers an international stepped wedge cluster rct in six european countries

chronic obstructive pulmonary disease copd is a devastating lifelimiting lung disease with a high personal and societal burden worldwide copd is the third leading cause of death the symptom burden of people with copd is as severe and burdensome as the symptom burden of people with lung copd while palliative care in many countries is available for people with lung copd palliative care and good endoflife care for people with copd are not well integrated into their treatment by respiratory hospital teams in europethe eu palcopd project is a multidisciplinary interprofessional international and intersectoral project aiming at evaluating the clinical and costeffectiveness of the icleareu intervention for people with advanced copd in different healthcare systems in europeicleareu is a personcentred and familycentred nonpharmacological service intervention in which respiratory teams in the hospital collaborate with interdisciplinary palliative care teams and with primary care to promote shared decisionmaking and advance care planning improve symptom treatment and comfort care and prevent rehospitalization after an exacerbation icleareu is based on an existing intervention developed and pilot tested in the ukin eu palcopd the effectiveness of icleareu will be assessed with a stepped wedge cluster rct in 1224 people with advanced copd in 18 hospitals across six european countries it is hence the first largescale international trial on systematic integration of palliative care in respiratory care for people with advanced copd costeffectiveness robust mixed methods subgroup analyses and indepth process and implementation evaluations are also includedeu palcopd will improve the wellbeing and empowerment of people with copd and their families and advance the state of the art by providing an innovative service model to the complex palliative and endoflife care needs user and stakeholder involvement is crucial throughout the project
development and commercialisation of a novel needle tract sealant system for pneumothorax prevention during lung biopsy

every 30sec someone somewhere globally dies of lung cancer eu records 320000 pa new lung cancer cases early lung cancer diagnosis can save lives through timelyefficient interventions ct guided lung biopsy is the gold standard for lung cancer screening however it comes with 62 inherent risk of lifethreatening complication pneumothorax ptx a complete or partial lung collapse ptx sufferers require further radiological scans needle aspiration chest tube insertion or surgery requiring additional hospital stay 15k costofcare currently no method or device prevents ptx during the percutaneous needle access of lungour patented selio system will be worlds first system specifically designed to prevent ptx occurring before biopsy even takes place used by an interventional radiologist before lung biopsy procedure in a 2 min addon to the current standard of care selio system preseals the needle tract in tissue thereby preventing air blood leak from those organs
microbial ecosystems biology in the human gut

the gut microbiota has wideranging effects on host health and represents a promising target for therapeutic manipulation particularly in early life imbalances in the gut microbiota precede the dthe gut microbiota has wideranging effects on host health and represents a promising target for therapeutic manipulation particularly in early life imbalances in the gut microbiota precede the development of conditions such as overweight and immunological diseases which exert a significant burden on society and on individuals early identification and treatment of gut microbiota imbalance in childhood thus offers great potential in combatting these problems and will become an important part of health care in the future however achieving this goal will require a highlevel understanding of the processes that regulate the microbial populations currently our knowledge of the principles governing gut microbiota responses to treatments is insufficient for reliable and targeted microbiota modification i hypothesize that conceptual limitations are a significant reason for the current inability to reliably predict microbiota responses to treatments and to modify the microbiota in this interdisciplinary project based on daily multiomic time series of child gut microbiota and diet and health diaries i integrate the theoretical and analytical framework of population ecology novel nextgeneration metagenomicsbased highresolution quantitative microbiota profiling and genomescale metabolic reconstructions into an ecosystem model of the child gut microbiota the result will be an unprecedented level of understanding of how the gut microbes interact and respond to external forces the concept can be applied widely to study the numeric and functional microbiota responses to any treatment and to design targeted interventions based on the predicted responses the project represents the important next step in microbiota research from description to mechanistic understanding
aerobic and resistance exercise training for improving brainrelated outcomes

problem coronary heart disease chd patients have a 45 higher risk of cognitive impairment and dementia currently there is no effective therapy to prevent or cure those brainrelated diseases recent studies showed that physical activity is associated with better cognitive functioning and a risk reduction of cognitive impairment and dementia in the general population however studies in chd patients are largely absent evidence about the brainrelated health benefits of physical activity are mostly based on aerobic exercise but recent studies showed that resistance exercise also provides potent health benefits art4brain the overall aim of the art4brain project is to explore the effect of exercise and physical activity on cerebral blood flow as a potential mechanism of cognitive decline and executive functioning in chd patients physical activity levels can be an important target in the chd population since the prevalence of physical inactivity is high accordingly i will study the following scientifically and clinically relevant objectives 1 examine the effects of aerobic vs resistance exercise on global cerebral blood flow and other brain health outcomes such as cerebral vascularisation brain structure and function using innovative mri techniques 2 examine the association of objectively assessed combinations of behaviours across the full physical activity spectrum physical activity sedentary behaviour and sleep on executive functioning cognitive flexibility working memory inhibitor controlattention 3 translate scientific knowledge into a digital exercise training program by visiting the commercial partner exi relevance for science and candidate i will use innovative approaches to investigate the potential of exercise and physical activity to improve brainrelated outcomes in chd patients the studies and training are performed in a worldrenowned research group which will greatly expand my expertise and boost my scientific career
einfrastructure reflection group support programme 7

eirgsp7 will provide the core support services to the einfrastructure reflection group eirg the project will support eirg in providing advice on policymaking towards inclusive federated userdriven and resilient einfrastructures and their related services the main activities include the operation of the eirg secretariat ie organisation of eirg events and provision of secretarial support to eirg its chair and executive board and the provision of policy support towards the development and publishing of policy papers and recommendations on the einfrastructure spectrum as well as the support to related eirg working groups and task forces which are also vital for eirg the eirg analytical capacity for its policy documents will be strengthened with external experts both from the eirg delegates and their countries and from wellknown experts in the filed who are invited as speakers in the eirg workshops the communication and outreach activities include the dissemination of the outputs of eirg throughout the european research area era the external and internal eirg web presence and maintenance of the social media outlets liaison activities are also planned with targeted stakeholders such as esfri related ones to jointly underpin the interworking of einfrastructures with the thematic infrastructures through these supporting activities by eirgsp7 and in its capacities eirg will contribute to the implementation of eosc including better coordination among national entities eg nrens national computingclouds infrastructures and to a more inclusive einfrastructure ecosystem the consortium is very experienced and wellconnected in the field through long involvement in previous eirg support projects and other eosc key projects and can contribute towards better einfrastructure coordination and the digital transformation in the era a new partner tuwien is also joining bringing experience from the eosc secretariat
digital observatory of political discourse

at a time when online discourse is increasingly controlled by private platforms like twitter and facebook and when fake news risks affecting elections and public health in europe and the united states there is a growing need for more transparency in online discourse digipol argues that misinformation is one attribute of a larger digital information ecosystem over which we urgently require oversight it launches a digital observatory of political discourse in the form of an online dashboard that tracks twitter discourse in realtime it is highly innovative instead of an opinion poll it models political science and media studies concepts populism expertise echo chambers and political identity to present complex information on online discourse to policymakers citizens platforms and researchers