Dragon09/odtu_chatbot huggingface dataset:
recycling locally produced biowastes to ensure affordability and availability of innovative biobased fertilisers

several studies have identified 3 main waste streams that are the most promising for being valorised to obtain biobased fertilisers bbfs 1 manure 2 sewage sludge and 3 food chain waste from these manure is the largest waste stream representing more than 70 of the nutrients but several studies have been conducted in the last 10 years aimed at its valorisation as bbf and have shown that it is a feasible feedstock for obtaining nrich streams and organic amendments that can be used directly as bbf but most of them are not suitable to be used as ingredients for centralised high quality fertiliser production due to the presence of pollutants such as heavy metals mainly zn and cu and organic matter sewage sludge and food chain waste have not yet been deeply investigated at the levels required for industrial implementation such that their fertilising potential is still underexploitedthe releaf project is based on the advancement and widespread demonstration in 5 technology demonstration sites of a suite of extraction techniques to produce key bbf ingredients from waste streams prevalent across europe sewage sludge fish processing waste and wastewater mixed food waste and agrifood residues the formulation and production in 2 sites of costeffective bbfs will address the serious issues of externalities ie dependency on foreign supply chains p and k and petroleumbased resources n from fertiliser production and use in european soils together with security of supply and waste valorisation investigations of the effectiveness and replicability of the bbfs within the varying climate conditions and soil ecosystems of 4 different field demonstration sites in addition to cocreation activities will allow for regional engagement with stakeholders to promote widespread acceptance while industrial involvement will facilitate a rapid scale up and industrialisation of proposed technologies
innovative sediment management framework for a sustainnable danube black sea system

the danube river has played a vital role in supporting both human and animal life for centuries since the late 19th century human interventions have significantly altered the natural flow of the river to optimize its utility these interventions have included actions such as straightening the riverbed constructing hydropower plants collecting freshwater establishing nuclear power plants engaging in agriculture and facilitating navigation the combined effects of climate change and extensive river regulation have led to a significant disruption in the natural balance of sediment in the danube river increasing flood risks altering hydropower production decreasing navigability of the river and affecting in biodiversity within the danube basinsundanse willcarry out a conceptual driverpressurestateimpactresponse with multiple levels of analysis catchment level water body level etc to understand and address environmental issues of the uniqueness of danube river lighthouserealize maps for observation of critical points for excessive sedimentation andor excessive erosion sediment transport and flow restorationperform innovative actions of measurements using cuttingedge portable onvessel equipment prototypes for the direct analysis of microplastics and toxicityachieve an advance numerical prediction model of sediment transport process in the danube river basin to have a comprehensive overview of river dynamicsdevelop an innovative sediment management framework for enhanced and sustainable sediment management within the danube river basinproduce an action plan and roadmap for associated regions to upscale demonstrated sustainable and effective solutions for sediment managementfulfil interconnections synergies with danubesediment and simona projects and icdpr initiativesimprove the trans national and cross sectorial cooperation contributing to a better governance in region and to implementation of eu strategi
role of reactive microglia and intraneuronal amyloids on neuronal vulnerability in early alzheimers disease

the recently approved drugs for alzheimers disease ad targeting amyloid plaques removal only mildly slow patients cognitive decline as neuronal loss starts decades before plaque deposition to delay ad onset before symptoms development prevention of neuronal death should be prioritised instead an early ad pathological event is intraneuronal accumulation of amyloids intraa which can cause neuronal death at the preplaque stage intraa is only found in specific neuronal subtypes first to be lost in ad suggesting it might underly their selective vulnerability reactive microglia could contribute to intraa as blocking neuroinflammatory processes in early ad reduces its accumulation whether microglia also contribute to intraa neurons selective loss is still unknown but could suggest repurposing of already available microglia targeting drugs for early neuroprotective therapies i will test this hypothesis in 5xfad mice first confirming intraa accumulates in the neuronal subtypes selectively lost as it occurs in humans i will analyse the contribution of reactive microglia to intraa neurons death by pharmaceutically rescuing their reactivity and determine if intraa neuronsassociated microglia express ad highrisk genes which drive late ad pathology because ad affects women more possibly due to their higher inflammatory response the sexspecificity in the previous analyses will also be tested finally i will establish microgliacontaining human brain organoids to recapitulate this synergy in a in vitro human ad model providing a foundation for future drug testingby determining the potentially detrimental interplay between microglia reactivity and intraa neurons using both in vivo and in vitro models my project will lay the basis of extensive future work while defining my research niche in the long term my results will impact development of novel neuroprotective therapies for treating ad before neuronal loss
electrifying peptide synthesis for directed evolution of artificial enzymes

global climate and energy challenges require efficient robust and scalable catalysts for the conversion of renewable energies nature has evolved extremely active catalysts enzymes for the conversion of small molecules relevant to energy h2 co2 n2 the scalability of these enzymes offers distinct advantages over the rare precious metals that are currently used in energy conversion unfortunately the enzymes are unable to tolerate the extreme conditions of operating fuel cells or electrolyzers directed evolution is a powerful approach for improving enzymes but is mostly restricted to natural amino acids and biological conditions with limited compatibility for evolving enzymes toward enhanced resistance in abiotic systems here i aim to establish directed evolution in fully abiotic systems using artificial amino acids to make artificial enzymes that are stable even in extreme conditions towards this i will establish new electrochemical peptide synthesis platforms to enable the generation of enzymelength peptides using both natural and artificial amino acids extended libraries of artificial enzyme variants will be produced and screened directly on electrode microarrays top enzyme candidates for the conversion of h2 will be selected using fuel cellelectrolyzer conditions as the evolutionary criteria by the end i will have a new procedure for synthesizing libraries of fulllength artificial proteins enabling the creation of thousands of enzyme variants using artificial building blocks the generation of highquality datasets will be transformative to drive future machine learningbased evolution steps for both full size enzymes and smallmolecule catalysts with applications beyond h2 evolution we will have discovered highly active catalysts able to sustain conditions of largescale energy conversion devices accelerating breakthroughs toward the economically competitive use of renewable energies for fuel and chemical production
a function for sleepdependent tau dynamics

dysfunction of protein tau is the main cause of dementia dementia associates with synaptic failure and sleep disturbances but their connection remains elusive in dementia tau becomes hyperphosphorylated ptau causing synaptic loss temperature fluctuations also associate with tau phosphorylation for example in hibernating animals intriguingly my work demonstrates that brain temperature decreases during sleep and further evidence suggests there are tausites phosphorylated during sleep my hypothesis is that sleep and temperatureinduced tau phosphorylation drives synaptic plasticity changes during sleep to investigate this i will map the dynamic changes in ptau during sleep and then delve into the mechanisms by mimicking brain temperature changes that naturally occur during sleep in humaninduced neurons and mouse primary neurons employing genome engineering i will interfere with ptau during sleep in mice in vivo and evaluate its impact on sleep sleepdependent synaptic plasticity and hippocampal longterm potentiation this research challenges the notion that ptau solely drives disease progression exploring a physiological function for ptau in regulating synaptic plasticity during sleep the result of this project can challenge our understanding of taus function and open a new therapeutic avenue the development of sleepwake mechanisms to reverse the pathological ptau state observed in dementia with my host labs prior track record of uncovering critical insights into tauinduced synaptic dysfunction it stands as the perfect platform to tackle these questions additionally i find myself in an ideal position armed with exciting preliminary data that bolsters the validity of this proposal and a robust technical and scientific background that empowers me to embark on this ambitious research journey the plan i propose brings us closer to breakthroughs in effective dementia treatments
disaster resilience knowledge network promoting innovation technology uptake and multistakeholder cooperation

the number and severity of disasters are increasing in europe due to climate change ageing of industrial facilities and infrastructures geopolitical instability poor knowledge management for critical activities and the vulnerability of the population exposed density age migration to face these challenges firefighters rescuers emergency medical responders and civil protection staff have to implement effective and affordable solutions to support their operations the direktion project will establish and implement mechanisms and procedures to enhance knowledge sharing by directing the development of innovative technologies answering the needs of practitioners and policymakers the steering role of international organisations ctif feu and endusers will guarantee useful and practical resultsthe project starts with the deployment of tools assessing the relevance and interoperability of innovative technologies developed by eu horizon projects a structured analysis of needs and gaps and the screening of potential solutions will then be undertaken the procedures will use the outcomes of projects like firein driver cmine medea the pilot for the network of european hubs for civil protection and crisis management and will follow the taxonomy of the eu security market study to ensure a structured use of results based on the capabilitydriven evaluations and a detailed analysis of the opportunities and constraints for the uptake of innovative solutions direktion will establish priorities for future research programming and capacity building moreover the project will further establish networking and dissemination opportunities of interest for the drs community in close collaboration with industry smes startups research organizations and practitioners at eu and national levels direktion will strengthen current practice and future research and innovation planning in disaster resilience
disentangling and preventing economic violence against women

violence against women is a violation of fundamental human rights and substantially compromises womens health wellbeing and empowerment globally more than one in four women experience physical andor sexual violence by a partner in their lives this risk is considerably higher among women in low and middleincome countries and in cultures with pronounced patriarchal gender norms however existing research has so far neglected an important dimension of intimate partner violence ipv economic abuse this form of abuse includes denying women the right to participate in financial decisions taking away their income or preventing them from seeking employment the consequences are profound economic ipv compromises womens economic welfare and independence traps them in abusive relationships and adversely affects their mental health to tackle this major global health concern ecovi has three objectives first to establish the prevalence of different forms of economic ipv second to develop a theory of economic abuse by investigating drivers of economic ipv and linkages with other forms of ipv and third to design and test a communitybased prevention approach to this end i will focus on india which is home to 670 million women and girls and exhibits high levels of gender discrimination that exacerbate womens vulnerability to economic ipv i will capitalise on a mixedmethods approach including i systematic reviews and metaanalyses ii conducting qualitative indepth interviews and focus groups and iii implementing a cluster randomised controlled trial and innovative survey experiments with husbands and wives in 150 indian communities ecovi will generate the largest existing database on economic ipv and establish an evidenceinformed prevention approach this has the potential to yield groundbreaking scientific and programmatic evidence on how to alleviate the economic violence and associated economic hardship that women worldwide are facing
past solar storms the links between solar storms and solar activity

our sun is a remarkably stable energy source which is crucial for life on earth however we know that the sun exhibits variations on a wide range of time scales occasionally violent eruptions on the suns surface socalled solar storms release energetic particles that can damage our modern society nowadays the sun is constantly monitored and a wealth of information has been obtained about its variability from groundbased and satellite observations however our sun exhibits variations that exceed the range measured during the space era as evidenced from sunspot observations over the past 400 years similarly as demonstrated by historical observations and indirect proxy data the sun can produce solar storms orders of magnitudes larger than anything observed during the space era presently we do not know the recurrence rate of large solar storms and how these are linked to solar activity mapping out the linkages may help to understand underlying processes and to predict the risks for future eventsto achieve this we can take advantage of the natural detector of past solar activity cosmogenic radionuclides in highly resolved and welldated natural archives i am proposing to develop this natural cosmic ray detector to increase its detection limit resolution and reliability for assessing solar storms and solar variability in the past this involves an assessment of the complete chain from solar energetic particles to cosmogenic radionuclide deposition for groundtruthing of the natural cosmic ray detector furthermore novel ice core sampling and improved analytical methods will allow us to produce an unprecedented database for these studies we will test hypotheses of the recurrence rate of solar storms and their relationship to solar activity our results will extend space weather research to millennial time scales and lead to a ground breaking new understanding of the temporal variability of our star
the last formation dating recrystallisation events of evaporites using lyoluminescence

sufficient knowledge of the timing and dynamic of quaternary last 258 million years climate phases through palaeoenvironmental studies is indispensable for accurate risk assessment and decisionmaking towards climate resilience of our modern societies geochronological frameworks are the backbones of such studies and new and innovative chronological tools can further boost their impact and value towards a better adaption to climate change our project lyoluminescence is about innovation in geochronology designed to contribute to the mission goals of horizon europe adaption to climate change lyoluminescence is the emission of light while dissolving a previously irradiated solid such as sodium chloride into a liquid solvent water due to the production of free radicals in the solution the amount of light increases proportionally with the radiation dose absorbed by the material after crystallisation therefore the process is a suitable candidate to be exploited as a dating method the signal resetting through dissolution and recrystallisation renders lyoluminescence a potentially dating tool for the last 10 thousand to 5 million years the aim of this project is the breakthrough development of lyoluminescence as a dating tool on salts sodium chloride and potassium chloride for application in geography earth sciences we hypothesise that lyoluminescence naturally occurring in salt minerals such as halite and sylvite will allow dating the last recrystallisation event beyond the age limits of conventional luminescencedating methods and that these features can be exploited for routine use in quaternary geochronology our project will 1 design develop and test a new portable lyoluminescence reader 2 apply the newly developed device to natural salt sites to develop dating protocols and analysis routines and 3 if successful map out a commercialisation plan the project will be hosted at the ruprechtkarl university of heidelberg germany
the mathematics of quantum propagation

strongly interacting and strongly correlated quantum manybody systems are at the forefront of modern quantum physics experimentalists have obtained unprecedented control on the interaction parameters and are able to reliably produce striking fundamental phenomena these problems demand a rigorous mathematical treatment but analytical methods are extremely scarce outside of special scaling limits the gold standard are liebrobinson bounds lrbs which provide an a priori bound on the speed of information propagation with broad physical implications however for the important classes of a lattice bosons and b continuum fermions and continuum bosons the standard derivations of liebrobinson bounds break down because these systems have unbounded interactionsthe first goal of this project is to establish propagation bounds including lrbs for lattice bosons and to identify the true behavior of information propagation for these systems this is the missing puzzle piece to develop a quantum information theory of lattice bosons that is on par with the revolutionary findings for quantum spin systems the second goal is to develop propagation bounds including lrbs for continuum fermions and bosons these systems present even more fundamental challenges due to ultraviolet divergences as an application i aim to close a glaring gap in our understanding of continuum quantum manybody systems the existence of the thermodynamic limit of the dynamics i recently developed the astlo method which uses bootstrapped differential inequalities microlocalinspired resolvent expansions and multiscale iteration to pioneer particle propagation bounds for the paradigmatic bosehubbard hamiltonian this resolved longstanding problems in mathematical physics my new astlo method is a robust proof template in combination with the technique of truncated dynamics it enables me to now tackle even more challenging open problems about information propagation
consolidating research and policy along the cognitive computing continuum

the transition from h2020 to he reflects an ongoing megatrend in ict the convergence of cloud edge and iot this tendency has significant impact in europe at scientific technological socioeconomic and geopolitical levels as these traditionally separated fields are now converging into a much larger ecosystem now sharing a number of common challenges and key priorities upcoming rias should integrate and capitalise on ongoing efforts with a vital aspect for europe in this whole process being to successfully combine and consolidate the technology priorities defined by eu industry through the european alliance for industrial data edge and cloud and the advancements that the ipceicis will provide in the coming years this transition and the move of the whole community of ecfunded projects and related initiatives towards a closer cooperation with industry is what the nexusforumeu project aims to support and facilitate by focusing on consolidating research and policy along the cognitive computing continuum something crucial to effectively expand what the ongoing csas particularly eucloudedgeiot are working on thus providing a clear consistent vision for future research and innovation topics in this eu strategic area nexusforumeu through its unique consortium will be able to effectively undertake a number of crucial activities such as producing annual research roadmaps and policy recommendations fostering collaboration between industry and academia creating solid links with the ipceicis and the european alliance for industrial data edge and cloud collaborating with past and present rias in order to promote a diverse eu research and innovation community identifying relevant issues such skills development gaps analysing the relationship with crucial topics such as open source and open standards and engaging with forwardlooking research and innovation communities and strategic initiatives outside europe starting with japan south korea
reconstruction of global redox transitions based on an evolving precambrian biological carbon pump

the history of life on earth is intricately tied to the story of molecular oxygen o2 given that we breath o2 every day the quest to understand its rise over billions of years is inherently tied to the fundamental question of our existence however critical turning points in our planets oxygenation including the great oxidation event continue to escape our full comprehension o2s narrative involves a complex interplay of microbial life biogeochemical processes and geological factors all intricately woven into the carbon cycle within the web of transformations a black hole persists the biological carbon pump bcp the bcp is a crucial component of the earths carbon cycle sequestering carbon from the atmosphere and transferring it to the ocean depths for burial over geological timescales this burial process directly impacts global o2 levels making the understanding of the ancient bcp crucial for unlocking earths oxygenation mysterieshowever deciphering how the ancient bcp functioned is challenging as insights from the modern bcp which is predominantly shaped by complex life forms offer limited guidance when it comes to understanding its ancient counterpart which operated in a world ruled by microorganisms retropump sets out to unveil the secrets of the precambrian bcp by reconstructing an ancient and evolving bcp with the goal of unravelling its regulation of o2 levels it challenges the conventional view of a less efficient precambrian bcp and explores uncharted relationships between microbial carbon cycling and major o2 transitions this journey follows a simulated ocean pipeline from the sunlit photic zone to the deep ocean culminating in an integration of insights into a numerical framework by tackling the drivers behind earths oxygenation retropump has substantial implications for understanding how the interplay of biological and geological factors ultimately paved the way for the rise of complex life as we know it today