Dragon09/odtu_chatbot huggingface dataset:
statistical theory and methodology for the combination of heterogeneous and distributed data

data is now collected at unprecedented scales across many industries meaning that there is huge potential for evidencebased advances in science technology and public policy however to harness this potential we must navigate repositories that are often a far cry from the idealised datasets carefully collected and curated under perfect conditions that are usually imagined when new statistical methodology is introduced data are often gathered quickly and cheaply patched together from multiple locations with limited regard to enforcing experimental standards we may have the large sample sizes we desire but there will be missing values misaligned datasets contamination and depending on the sector there may be noise added purposefully to satisfy individuals and regulatory bodies privacy concernswe propose to address such difficulties through the development of new statistical methodology and theoretical frameworks that explicitly incorporate various forms of data heterogeneity and measurement error this will be divided into four main areas1 accounting for sampling bias when a complete dataset is complemented by additional incomplete datasets this will be studied through the lens of semiparametric theory for functional estimation2 combining two or more datasets that record overlapping but distinct sets of variables where few or no complete records of all variables are available these file matching problems will be studied using new developments in statistical optimal transport3 examining the effect of the violation of missing data assumptions here we will introduce techniques from robust statistics to mitigate the error due to misspecifying assumptions about sampling bias4 securing individuals private data through the intentional use of noisy measurement here we contribute to the growing field of differential privacy specifically the userlevel local variant where distributed batches of observations are privatised simultaneously
an ontological reconstruction of gaming disorder a qualitative metaphenomenological foundation

videogames have become one of the most prevalent forms of cultural production around the world while their role in teaching and physical culture esports keeps growing the health debates on videogame play or gaming culminated in 2019 with the world health organizations historical decision to add gaming disorder to the international classification of diseases this made gaming next to gambling the first and only cultural product with a diagnostic category of addictive use the above echoes a greater conflict between culture and human development how can science address potential problems in intensive technology use when intensive use is also globally integrated into healthy everyday living to build a foundation for answering this question i pursue a metaphenomenological taxonomy of intensive gaming on three levels of lived experience play health and design interaction the taxonomy is metaphenomenological in the sense that it is structured on the experiences of intensively gaming individuals these experiences surface in distinct sociocultural contexts in interaction with specific videogame designs which are the studied metaareas this interdisciplinary project is crosscultural longitudinal and qualitative participants with and without health problems n240 will be followed for three years in south korea slovakia and finland in collaboration with clinical experts phenomenological interviews are carried out with diaries that include gaming activity logs the design structures of the videogames in the participants lives are analyzed to map out the phenomenological forest of health and play with specific design interactions the elements are refined into a taxonomy that not only serves as a new foundation for gaming disorders but also situates such instances in the colorful spectrum of diverse lives and designs at largeproviding grounds for sustainable future theory development at the intersection of health culture and design
characterising the molecular and cellular basis of enteric nervous system alterations in the inflamed gut

inflammatory bowel disease ibd encompasses two gastrointestinal conditions crohns disease and ulcerative colitis which currently lack satisfactory treatment ibd is associated with alterations to the enteric nervous system ens of the gut including the formation of new neurons neurogenesis and changes in the properties of existing neurons neuroplasticity growing evidence suggests an interplay between acute inflammation and ens pathology despite this detailed characterisation of ens alterations their underlying molecular mechanisms and how inflammation may induce them during ibd is not well understood the marklund laboratory has recently uncovered a stepwise diversification model of enteric neurogenesis suggesting that during embryonic development subtype identities are specified through identity conversions in postmitotic neurons this work leads to the intriguing possibility that the identity of terminallydifferentiated enteric neurons may in fact be flexible however whether stepwise diversification is present during adult inflammationinduced neurogenesis and whether neuronal identity can be altered by extrinsic stimuli such as inflammation remains to be assessed using a colitis model of ibd single cell rna sequencing of ens and immune cells and spatial transcriptomics neurogensity will characterise the composition of the inflamed ens revealing the cellular changes occurring as a result of acute inflammation pseudotime trajectory analysis in combination with lineage tracing experiments will address the nature of adult enteric neuronal identity specification ensimmune interactions which may underlie neurogenic and neuroplastic alterations will be identified and their relevance assessed using cell depletion assays together neurogensity will identify mechanisms underlying inflammationinduced alterations to the ens paving the way for targeted treatments of ens dysfunction during ibd
aienhanced fibrewireless optical 6g network in support of connected mobility

the 6gewoc project aims to contribute to the development of future 6gai based networks by ending with trl4level developments on critical technologies and devices for expanding the reach of 6g especially in high mobility scenarios it is addressing key societal value indicators kvi defined by the work programme and developing kv enablers such as services for coordination precise positioning and localization multiagent supporting network architecture and joint communication and sensing the three ambitions of 6gewoc focus on amb1 optical wireless communications owc for v2v and highrate gbs v2i applications chipscale optical beamformers and developing connected laserradio detection ranging and communication lidarradar amb2 pic and asic for tuneable transmitter and receiver concepts for fiberbased fronthaul supporting 50 gbps and 100 gbps per wavelength over dwdm fiber links and sdnenabled photonic switching amb3 focuses on aiassisted control and orchestration of resources for the multiband heterogeneous 6gewoc network concept and aibased applications development for autonomous vehicles up to 17 kpis are expected to be validated at three final demonstrationsin conclusion 6gewoc search to develop an aienhanced fibrewireless optical 6g network in support of connected mobility by creating a new access network for high mobility scenarios and expanding the reach of 6g through the integration of optical and wireless technologies free space optics and joint communication and sensing it is supported by a fast reconfigurable highly dynamic and customizable optical fiber fronthaul infrastructure minimizing optoelectronic transitions by tuneable and programmable devices and low energy photonic switching of packetoptical spectrum and spatial resources controlled by aibased sdn providing endtoend connectivity between aibased edge computation units supporting connected mobility in a fast reconfigurable network architecture
endorsing safeguarding protection and provenance management of cultural heritage

enigma shall achieve excellence in the protection of cgs and artefacts from manmade threats by contributing to identification traceability and provenance research of cgs as well as by safeguarding and monitoring of endangered heritage sites enigma objectives are designed to help the involved stakeholders better respond to this complex and multidimensional problem and leverage active collaboration by fostering and enabling interlinking of databases and evidencebased deployment of preventative measures
worldtrans transparent assessments for real people

there are a few important working hypotheses that lie behind our choice of approach to this call for europe to deliver on its green deal ambition to make europes economy climate neutral by 2050 we believe that citizen engagement stakeholder engagement may be as important as dry facts and figures people not economies react to climate change people make decisions to act or not to act such is the nature of a democratic process it is this realization that has made us choose to address transparency openness engagement and to work with models of the system not its parts worldtrans will focus on three key limitations of the stateoftheart of iams namely1 weak representation of social human and economic heterogeneity 2 limited representation of feedbacks between the domains of nature and humans and 3 lack of transparency with respect to the inner workings of the models as well as with respect to the uptake of results and involvement of citizens and stakeholders including limited assessment and traceability of uncertainty we will address systemic structural deficiencies in current iams rather than making incremental improvements in doing so we sacrifice details of any particular sector or process instead capturing the essences of their functions in order to focus on how those processes affect each other within and across domains worldtrans will use system dynamics methods and modelling to deal transparently with multiscale issues and policy response options and bridge gaps between models experts and user communities by developing attractive learning environments that allows for simulations of decisionmaking processes and joint reflections of meaning and implication as such worldtrans will deliver actionable results in support of the expected impacts and outcomes requested by the call
maternal and infant safety and immunogenicity in a phase 3 openlabel randomised vaccine trial of a twodose mpox vaccine

mpox can cause severe complications in vulnerable groups such as pregnant women and children necessitating targeted public health interventions and vaccine trials in these populations limited data suggest the mvabn vaccine is safe for pregnant women and likely poses no risk to breastfed infants but comprehensive human data are lacking trials in endemic areas are crucial for evaluating the vaccines safety and efficacy in realworld settingsvaccine hesitancy exacerbated by misinformation and distrust in healthcare systems poses a significant challenge especially in the democratic republic of the congo pregnant women are particularly affected by concerns about vaccine safety which influences their willingness to vaccinate addressing these concerns through targeted communication and community engagement is vitala proposed phase 3 randomized trial will assess the safety and immunogenicity of the mvabn vaccine in healthy pregnant and postpartum women and in infantschildren 624 months old additionally a qualitative study on vaccine hesitancy will inform the trial design and implementation aiming to enhance vaccination uptake in these highrisk groups
european core technologies for next generation communicationcomputing hardware

the corenext project aims to build a computing architecture and digital components for sustainable and trustworthy b5g and 6g processing this architecture must support an open multivendor and multitenant disaggregated ran by employing virtualization technology a step forward in digital component design must be made to address the compute throughput and energyefficiency requirements this is addressed by the development of powerful and efficient heterogeneous accelerators purposebuilt for ran computation and signal processing as well as ultrahighspeed and lowpower interconnects to support disaggregation of compute resources a cornerstone of the project is trustworthiness the pervasiveness of b5g and 6g use cases requires deeply embedded hardware trust anchors to fulfil the vision of secure disaggregated compute systems to realize these goals the project brings together major telecommunications and microelectronics players as well as academic research partners a strategic roadmap will offer a transparent path towards future exploitation of the generated research results fostering a continuing european strategy for the emergence of european digital capabilities in this communicationcomputing domain
the evolution of logic

our ability to reason by logic is exceptional in nature we are the reasoning animal like all animals we evolved during a long natural process unlike other animals we developed sophisticated minds and a complex language that contains logical structure yet it is remarkably unclear how logic became part of nature where does logic come from the goal of this project is to understand the origins of the human capacity for logical reasoning merging philosophical logic and evolutionary linguistics the general hypothesis is that logic evolved to support social interactions and efficient communication the particular focus will be on the evolution of quantificational reasoning which is key to the ability to generalize and to count there are three parts to this project first to explain what we have the grammar of natural language includes simple words to express quantification every always what were the conditions for the emergence of the cognitive abilities thereby manifested in speech second to explain what we dont have no language of the world includes simple words for concepts such as not every and not always these quantifiers have to be expressed compositionally by combining simpler building blocks not with every and often this is not a coincidence the difference between what can be expressed as a lexical item and what must be expressed by composition is the difference between what can be memorized by the child acquiring a language and what must be generated by the grammatical engine third to explain how it all comes together is logic the result of natural selection cultural inheritance or something else the study of logic from an evolutionary perspective will provide a window into the origins of the human mind with a wideranging impact on philosophy and neighboring disciplines
the financial gender gap

the financial gender gap ie the wellestablished gender differences in financial decisions has been the subject of much recent discussion and debate we know little about what drives this gap though because the financial decisions of individuals play an extensive role in determining welfare in all stages of life the identification of the contributing factors is of crucial importance this is the pioneering goal of genderinfinance the overall concept and central contributions of genderinfinance are the following 1 the project innovates by creating a unique panel data set comprised of a rich set of experimental measures including beliefs expectations preferences and the decisionmaking abilities of individuals merged with a panel of detailed highfrequency transactionlevel bank data capturing both realworld financial decisions and constraints of individuals no comparable data set exists and it enables the identification of the factors that contribute the most to the financial gender gap in reality 2 using this data set the project offers groundbreaking evidencebased understanding of the gender differences in financialchoices along several dimensions that contribute to financial wellbeing 3 by identifying the factors that contribute to the gender gap in financial choices the project informs the development of models of financial decision making ultimately this research agenda will shed light on what drives gender differences in financial decision making as well as which policies may be effective in narrowing these gaps specifically the novel insights i aim to provide is expected to lead to substantial improvements in the methods used to fight the financial gender gap as the better understanding of the forces behind the financial gender gap will inform the current debate on this issue and provide important lessons to policy makers who have gender equality on their agenda
minority rights towards effective european enforcement

ongoing crises like the return of war to europe economic hardships and the illiberal challenge raise worries about minoritymajority relations anew while one can hardly expect the adoption of strong prominority reforms in the short run innovative solutions are needed that strengthen minority rights while remain politically realistic minotee builds on the trend that faced with limits of current approaches to legal enforcement european institutions have been experimenting with forms of collective redress the logic and benefits of this type of remedy are relevant to guarantee minority rights but its potential is understudied i argue that more reliance on collective redress should ensure better enforcement and can work independently from major prominority reforms by drawing from methods in legal studies and political science minotee would open up novel understandings of how opportunities shaped by ethnic bargaining positions and perceptions of power relations play out in legal procedures and beyond openended this new approach should gauge the impacts of aggregation while delving into the actorbased dynamics that empower minorities against the lack of rights enforcement the research will explore how collective enforcement shapes questions of representation and costs improves evidence triggers organization builds agency building on insights from early cases of minority reparation eg holocaust cases and seeking to develop solutions that are applicable for a range of minorities the research will focus on a limited set of cases roma and hungarian minorities in slovakia hungary and romania will be studied also allowing to assess how collective redress mechanisms can play out amid rule of law challenges minotee will develop proposals on how european institutions could adopt regulation on collective redress mechanisms to mark a leap in minority rights enforcement ultimately promoting effectiveness in ways that are tangible in local settings
learning sharing and codesign in innovation procurement between innovation suppliers and buyers

innobuyer aims to become a testing ground and benchmark towards the implementation of a demanddriven methodology that brings together procurers and innovation suppliers notably eic smes to jointly cocreate solutions to a common challenge proposed by the procurer while also facilitating the procurer adoption and the innovation supplier commercialization of the solutionthe project will foster the development of an ecosystem to promote collaborative innovation between the best european public and private procurers and innovation suppliers in particular eic projectscompanies launch and validate a support programme to cocreate innovation between buyers and suppliers the programme will be demanddriven and geared to adoption by design demonstrate the increase of efficiency of eu public but also private services via piloting 15 innovative solutions notably the ones from the eicfunded projectscompaniesit will do so by executing four sequential actions action 1 recruitment and aggregation of procurers partners will launch a dissemination campaign to recruit unmet needs from procurers and then select the 15 best candidates other interested public and private procurers will be aggregated to the selected challenge so they can also acquire knowledge along the projectaction 2 buyersme matching partners will support buyers to launch an open market consultation to receive feedback on their challenges then they will recruit and award suppliers to answer to the proposed challenges action 3 pilot cocreation procurers and suppliers will jointly cocreate solutions to the challenges the solutions will be tested and evaluated suppliers will receive support towards future commercialization of their solutionsaction 4 terms of reference delivery support the creation of tors in collaboration with external experts as the base for a future tender for the solution by the procurers
intermittent androgen deprivation therapy in the era of androgen receptor pathway inhibitors a phase 3 pragmatic randomised trial

prostate cancer is the most common cancer in european men despite dramatic improvements in early diagnostic and local treatment one out of five prostate cancer patients will die from their disease despite progress in the past years it remains critical to improve on the present strategy for advanced and metastatic prostate cancer within the proposed project we will evaluate whether intermittent intensified androgen deprivation treatment iadt in metastatic prostate cancer is not inferior to continuous treatment in terms of oncological benefit while minimizing side effects and resource utilization and improving patient quality of life the proposed clinical trial is designed to detect early if iadt has a negative impact on overall survival compared to continuous therapy if successful the outcomes of the project will define a new evidencebased standard of care for metastatic hormone sensitive prostate cancer the proposed research could lead to improved patient survival and quality of life but also improve health system sustainability this is a multidisciplinary and multistakeholder consortium involving clinical oncologists surgeons health economists and patient representatives the study design was successfully discussed with patients this action is part of the cancer mission cluster of projects on diagnosis and treatment
model reduction for complex systems with exponential nonlinearity via geometric singular perturbation theory

important aspects of nonlinear complex systems like the earths climate gene regulatory networks or the global telecommunication network can be modelled mathematically by systems of ordinary differential equations however the dynamics of such systems can rarely be understood by direct numerical simulation due to significant problems including high dimensionality strong nonlinearity and processes occurring over a wide range of timescales this leads to the necessity of model reduction ie the identification of reliable methods for discarding unnecessary details to obtain a simpler reduced system whilst preserving the salient dynamical features of the original system existing approaches to model reduction rely on a combination of methods which i exploit multiscale structure in order to decompose the problem into lower dimensional subsystems and ii reduce nonlinearity by replacing highly nonlinear terms by piecewisesmooth pws approximations despite substantial progress in particular applications a sound mathematical basis is often lacking and existing methodologies sometimes lead to qualitatively different resultsthis project addresses a number of limitations to existing model reduction techniques by developing a mathematical formalism which we call gsptexp we begin by building upon recent developments in geometric singular perturbation theory with the aim to formalise recently identified connections between pws systems and multiscale systems with exponential nonlinearities via multiple novel adaptations of a geometric method known as blowup the gsptexp formalism will be developed and used as a mathematically sound method for model reduction of i classical model problems from combustion and ii gene regulatory networks finally in an ambitious interdisciplinary collaboration with systems biologists we aim to couple gsptexp with emerging techniques based on tropical geometry to study and simplify iii biochemical networks