Dragon09/odtu_chatbot huggingface dataset:
ai in parkinsons disease

in response to the growing need for specialized data scientists in healthcare our initiative aims to establish an international interdisciplinary graduate school that educate the next generation of medical data scientists with a strong translational focus bridging academia and industry this is strengthened by the active involvement of leading global pharmaceutical and medtech companies as well as smes in the ai field thus ensuring that our research and training remain at the forefront of industry and healthcare we propose a comprehensive training program offering phd students not only a robust foundation in data science including aiml and digital health but also a deep understanding of ethical legal and regulatory frameworks including gdpr the european health data space and the ai act our curriculum is unique in its integration of entrepreneurial thinking and a focus on parkinsons disease pd as an application field at the same time the methodologies and insights gained will have broader applications in various disorders thus applicable to other areas of healthcare we will move with our research program clearly beyond the state of the art by developing new aiml models spanning the entire journey of a pd patient to support medical decisionmaking on a more individual basis pioneering the use of recent causal aiml techniques in pd research investigating the optimization of future clinical trials providing novel insights into digital and neuroimaging markers developing innovative algorithmic solutions to enhance the generalizability of aiml models providing understanding of the ethical legal and regulatory basis of the use of ai in medical practiceall participants are highly committed to the research teaching supervision and management activities in this program and this commitment is supported by existing working relationships through other projects such as era permed digipd ihi predictom and ihi iderha
pressurized efficient alkaline electrolyser peace

among the different electrolysis technologies ael is very competitive because of its low investment costs and good scalability the levelized cost of hydrogen lcoh produced by ael can be reduced by enhancing the efficiency maximal current densities and by enabling better integration with downstream processes a welltuned design of highpressure stack and system improve the performance and overall efficiency by eliminating the need for further compression for downstream processes as compressors for hydrogen represent a significant share of capex and opex of electrolysis systems those can be reduced or eliminated in this project the consortium will design and develop an ael system demonstrator 50 kw capable of operating at a pressure up to 90 bar achieved by a novel concept in which the pressurization is done at two stages by applying up to 60 bar hydraulic pressure using a pressure vessel in which a stack operates at additional 30 bar resulting in up to 90 bar gas pressure integrating advanced components innovative design and optimizing operation strategies through modelling and experimental testing a system with an efficiency of 70 lhv at a current density of 1 acm2 will be demonstrated with this technology an ael system will be provided that may lead to major cost reduction of green hydrogen production the main scientific aims of the project are further supported by sustainability and circularity aspects as well as dedicated outreach activities and jointly addressed by 2 mediumsized enterprise smes 4 rd centres with established expertise in alkaline stack system and life cycle assessment lca and one of the largest hydrogen production and utilization companies in the world lastly use cases and the concept of the integrated plant will be proposed together the new developments will target a technology breakthrough with a clear commercial perspective placing europe at the lead of highly pressurized ael technology in 3 years
precision climate resilience for agriculture and forestry sectors in the european boreal regions

climate change affects boreal regions and their communities severely as these areas are warming three times faster than the global average primary producers such as farmers and forest owners actors face a significant challenge when it comes to adapting to these changing conditions they need tested proven solutions to help them adapt and so become a resilient primary production sector we need to bridge the gap between science which has the knowledge and solutions and targeted practical implementation with local actors who will use them precilience therefore applies an inclusive and collaborative approach to test and demonstrate various solutions for increasing climate resilience in the eu boreal region the most effective measures are tailored to their location we will collaborate regionally including with authorities to find the most relevant risks and suitable naturebased solutions together we will cocreate the most impactful adaptation portfolios for changing conditions in the agriculture and forestry sectors of 11 focal regions in denmark estonia finland norway and sweden 4 replicating regions will also benefit from the lessons learned and demonstrated solutions dkfinose we demonstrate handson solutions with local actors under 8 themed demonstrations a cocreate adaptation strategies b diversify agricultural production c sustainable water management and recycling d soil function enhancement by closertonature management and improvers f assess vulnerable forest types g innovative forest regeneration in droughtprone sites h closertonature forest management i use climateconsiderate tree material to replant forests we work with local stakeholders to further develop certain demonstrations this involves targeted collaborations based on stakeholder mapping and categorisation we involve all levels of stakeholders from small fast reacting units for localised fast impact to large organisations with longterm impact
deciphering stringent response proteins and toxinantitoxin systems in the arms race between bacteria and phages

bacteriophages viruses of bacteria are the most abundant life form on earth the prospect of using them in the fight against pathogenic bacteria has long been recognised but their very high specificity and unpredictable reproduction limits their use in medicine the mechanisms phages use to fight bacteria are attractive candidates for the development of novel antimicrobial applications but are still very poorly understood indirect evidence exists of toxin antitoxin systems tas and stringent response involvement in phage defence the constant coevolution of phages and bacteria suggests that phages have a way of overcoming all of the wide variety of bacterial defence systems yet no direct phage mechanisms targeting bacterial stringent response have been identified we hypothesise that as the bacterial toxinantitoxin systems and stringent response play a part in the arms race between bacteria and phages we can provide direct molecular evidence and identify phage proteins involved in these interactions by 1 creating and characterising morphologically and molecularly a novel library of phages infecting pseudomonas putida paw85 2 uncovering the stringent response and tasmediated phenotypic effects and their molecular mechanisms on p putida phage tolerance 3 discovering and characterising functionally and structurally the antitas and antistringent response phage effectors 4 determining the toxicity and specificity of the identified phagederived toxins by testing them on different bacterial species this study will bridge several gaps in the phagebacteria interaction research advance the research of phagetolerant bioremediation strains and give crucial basic knowledge that can lead to the development of novel efficient phage therapy solutions that target bacterial stressmechanisms
reframing european gastronomy legacy through innovation sustainability and heritage

through an innovative and systematic approach to the understanding and use of traditional eu recipes via digital and aipowered technology relish embarks in the production of a visual and verbal food storytelling web platform that aims to mediate social cohesion reinforce eu cultural heritage transmission at home and abroad through education and public engagement while addressing sustainable practices in the eu hospitality sector
systematic mapping of the chloroplast protein import system

protein import into a membranebound organelle in eukaryotes has been intensively studied leading to the discovery of the central intracellular import machineries yet this field has undergone a fundamental paradigm shift following recent discoveries of noncanonical import pathways in the mitochondria and er while the chloroplast is still thought to have but one import machinery tictoc accumulating evidence indicate it too has noncanonical pathways technological constraints have so far barred the systematic search for alternative import pathways as well as the exploration of central aspects relating to this import system are there additional import pathways other than the canonical chloroplast translocon apparatus what ensures correct targeting of proteins in the highly crowded cytosol to the chloroplast what mediates between quality control processes and protein importin chloroimport we will go beyond the stateoftheart by implementing multipronged genomewide unbiased approaches we developed or adopted to elucidate all the targeting pathways en route to the chloroplast in chlamydomonas specifically we will use advanced genomewide screening to comprehensively elucidate chloroplast import pathways aim1 uncover the functional organization of import pathways using geneticinteraction profiling and proteinproteininteraction mapping aim2 and conduct an indepth biochemical investigation of the function of unstudiednovel import factors aim3 to the best of our knowledge this is the firstever study of this scale in a photosynthetic eukaryote cell the outcome will be a complete map of the chloroplast proteinimport system pathways components regulators and a genetic platform for this systems indepth characterization it will further offer insight into basic questions in chloroplast functioning and may also pave the way to the synthetic engineering of crops that are more efficient for projected climate changes
mediterranean critical infrastructure resilience engineering with nature based solutions

the mediren project aims to provide actionable demonstration on how to climate proof the mediterranean critical infrastructures across critical sectors by introducing nbs both in terms of improving climate risk management and sustaining their business continuity to extreme climate change the project will be showcased in five lighthouse regions across the mediterranean each corresponding to a present day challenge that are aligned with regional policies and can constitute the eu as a global leader in the fieldmediren will cover different and diverse types of ci energy transport water ict social priority climate hazards within the mediterranean which is a climate hotspot and nbs interventions in parallel the interventions and solutions will be replicated into four more regions across the eu covering the mediterranean black sea and boreal regions mediren will also provide evidence how key enabling conditions such as participatory governance and citizen engagement novel forms of financing innovative urbanlandscape planning and capacity building will support regional systemic transformation nd provide the upscaling and replication mechanism within mediterranean regions and beyond a highend digital decision making support toolset will be developed integrating data from multiple sources both insitu and eo applying stateofthescience models as well as providing unprecedented visualization and sensemaking capabilities for understanding and quantifying resilience throughout the infrastructure and nbs lifecycle mediren will rely on the integration of the research output of more than 15 european and national projects that focused on the climate resilience of infrastructures regional adaptation and implementation of nbs mediren is conceived as a powerful showcase of the eu twin green digital transition and an immediate success story of the eu green deal
risk assessment innovation for lowrisk pesticides

low risk pesticides lrp including i plant extracts ii semiochemicals like pheromones and allelochemicals iii microbial pesticides are gaining ground in the global market as substitutes of synthetic pesticides in addition new microbial solutions phages protists microbial consortia and dsrna pesticides are emerging lowrisk solutions expect to reach the market in coming years despite ongoing regulatory efforts by the european commission we are still lacking a concrete risk assessment ra scheme relevant to lrps a point which blocks lrps reaching the eu market ration timely comes to address these regulatory constraints and aims to develop a novel ra scheme supported by the necessary guidance on methods and tools tailored to the specific characteristics of established and emerging lrp solutions this main goal will be achieved through a series of interrelated wps aiming i to map the current status of lrps in europe and identify main regulatory constraints wp1 in this quest it will be supported by a stakeholders forum composed of all relevant actors industry regulators academics famers general public ii to develop and validate through a proofofconcept exercise innovative ra and associated tools for microbials wp2 plant extracts semiochemicals pheromones wp3 and dsrna wp4 and from there iii build a harmonized ra for all lrp and determine its socioeconomic impact wp5 iv to effectively communicate and disseminate the new ra knowledge and its associated tools developed by ration to relevant actors ensuring sustainability beyond project duration wp6 ration will benchmark eu regulatory science uplift blockers holding back lrp uptake by the eu market and motivate research innovation in plant protection to achieve these goals 22 partners from academia industry and regulatory bodies representing 10 member states and 2 noneu member states will join forces in a multisectoral and multidisciplinary effort
lowering transport environmental impact along the whole life cycle of the future transport infrastructure

liaison provides knowledge and technical solutions to limit transport infrastructures ti emissions both caused by transport infrastructure itself and to which transport infrastructure contributes liaison covers the whole life cycle of ti to which extent ti design can influence and limit the overall emissions from construction maintenance operation and decommissioning of the infrastructure in a digital environment for next future ti liaison adopts a holistic approach to tackle this challenge because the development of particular technical solutions is not sufficient to achieve low environmental impact ti if they are not part of a broader strategy the only effective way to ensure the implementation of paradigmshifting technical solutions in the ti sector is to implement a governance framework as the dynamic multiinfrastructure governance framework dmigf that activates articulates and monitors compliance with circular economy principles throughout the life of the infrastructure when developing and implementing these solutions liaison will develop a collection of innovative technological solutions to reduce the environmental impact of the ti materials consumption emissions and footprint minimize their lcc and optimize energy management becoming prosumers which will based on in the industrialization of the construction process circular economy and digitalization of the operation maintenance and decomissioning tasks specifically the solutions to be developed are smart and sustainable beams rigid road pavements and improved ballast bioasphalts and smart pavement inspection system intelligent tunnels control system and photovoltaic guardrails liaison developments will be demonstrated in different ti roads and railways and in different european countries spain poland slovenia and italy
green borophene sensing

air pollution is the biggest environmental health risk according to the eu and it is responsible of several millions of premature deaths per year worldwide in consequence there is a growing demand for novel miniaturized affordable and reliable sensing devices able to detect pollutants at trace levels the environmental monitoring market is estimated to grow at a cagr of 41 to reach usd 1710 billion by 2025 within this market the air quality monitoring market size was valued at over 35b in 2018 and is expected to grow at a 7 cagr noteworthy through biogeochemical processes ie acid rain air pollutants released to the atmosphere can create a second pollution mechanism due to deposition in water surfaces thereby increasing the potential threat to human healthwithin this perspective grebos lies in the development of a comprehensive sensing strategy employing innovative tailored functionalised borophene as a versatile nanomaterial for detecting trace levels of pollutants in both water sers substrates and air chemoresistors samples this nanomaterial is at the forefront of research due to its superior and promising properties in addition borophene functionalisation with fluorine and phosphorous via lowenergy ion irradiation will be studied for the first time enabling novel studies about their changes in the electrical properties and surface chemistry besides pollutants as nitrogen oxides and ammonia will be detected in both matrices below the threshold limit values established by the european commission according to the directive 200850ec air quality and 9883ec quality of the drinking water
recycling of lithium from secondary raw materials and further

current recycling technology is focused on recovering li from battery scrap while hardly much focus and technological development is going towards other li sources hence the aim is to recover li from potential secondary sources in order to reduce unrecovered li from its waste generation which is estimated to be approx 2733 of the current global li production relief proposes an integrated recycling facility for li from secondary raw material sources with continuous processing to produce battery materials li wastes will be reduced by more than 70 which will instead be recycled into high value batterygrade material the results of the integrated and continuous process up to battery precursor recovery will be demonstrated at trl 5 and battery active material closedloop process will be demonstrated at trl4 with a 15 25 kgweek output of battery active materials and a new business model will be developed for the materials acquisition and processing taking into account environmental and social sustainability the expected results will contribute to decreasing the dependency of the eu on imported battery chemicals and raw materials relief will greatly strengthen the eus competitiveness in the battery storage value chainthe relief consortium consists of 12 partners six of which are smes abee ext eurice ist peg tc four are nonprofit rtos imnr inegi zsw nova and further two are universities lut ulb and one associated industrial partner lanx thus it a very high amount of industry involvement entirely in the form of innovative smes covering the technological and also the impact maximization related aspects of the project a perfect combination of basic research methodologies chemical process and analysis capabilities technology development in an industrial environment and strong ties to the recycling and battery industry and policymaking entities inside the eu
the afterlives of contract and enslavement narratives on indentured labour between cape verde and s tom and prncipe

this project provides the first comprehensive study on the entangled cultural memories of plantation indentured labour under portuguese colonialism in cape verde and s tom and prncipe from the 20th century onwards ghost addresses a gap in global plantation studies predominantly focused on the americas by exploring how and why the narratives of indentured labour known as contrato change over time in these two african archipelagos drawing on original and detailed empirical research ghost analysis is based on a diverse set of visual oral and written sources among others literary texts music cinema interviews newspapers articles photographs letters laws reports and other official documentation through which the project will trace the multiple and sometimes divergent cape verdean and santomean narratives linked to plantation work and contrato how they are mobilized and their changing symbolic and political uses through time the originality of this project derives from a groundbreaking interdisciplinary approach to colonial indentured labour underdeveloped experiences using the conceptual framework of haunting it argues for three distinct readings of ghosts and hauntings as spectral agents or the return of the dead as spirits that by transcending fixed boundaries of time and space through ritual possession or other mechanisms can disrupt dominant narratives of the past as a rhetorical device for addressing colonial violence and its persistent legacies in the present discussing notions of historical injustice and representation and as an active process of ghosting concrete subjects regarded as unworthy of social recognition by disqualifying and dehumanizing them suggesting a move towards decolonising haunting the project interdisciplinary in nature enables a critical dialogue between memory studies cultural history and postcolonial theories contributing to contemporary efforts of decolonising colonialimperial pasts
thermite reactions assisting satellite demise

this project develops a new method to manage the decommissioning of satellites through the use of onboard heat generation systems based on nonexplosive thermite charges called thermitefordemise t4d thermites are mixtures of metal and metal oxide which can undergo spontaneous exothermic reactions even in vacuum according to composition and production pioneering projects have demonstrated that t4d may be used to damage space components and support their demise during atmospheric reentry however its real world application needs the filling of knowledge gaps and practical problems a the powdered form is not the best way to obtain localized reliable heat release b the expected life cycle in a space mission has never been considered c a strategy for t4d use is not available the project targets the maturation of t4d technology in three major steps 1 new thermitebased composite materials granting thermite a structural consistency will be developed and their behavior characterized environmental stress tests will secure their use across satellite lifecycle 2 with these building blocks heatgenerating shapes and devices will be developed supported by the experience of a large spacecraft integrator the heat transfer behavior of thermitebased objects will be modeled and validated under representative reentry conditions in hypersonic wind tunnel results will support the update of systemlevel reentry simulation tools and the definition of application strategy further validated on demise test in wind tunnel with hardware of representative or simplified geometry from the selected usecases supplied by a space company 3 all previous outcomes will support a costbenefit analysis for t4d industrial implementation and its long term evolution the results of the project will demonstrate with new experiments and modeling approaches that t4d has the potential to become an engineering standard for the space community