Dragon09/odtu_chatbot huggingface dataset:
understanding the complex biology of ahr activation in cancer

the aryl hydrocarbon receptor ahr is a critical regulator of tumor progression by modulating both tumor cell intrinsic malignant properties as well as antitumor immunity however depending on the context the ahr can exert either tumorpromoting or tumorsuppressive effects thus limiting its potential as a drug target to exploit the ahr for cancer therapy a comprehensive understanding of its activation and biological outcomes is necessary the opposing effects of the ahr in cancer likely stem from the complexity of its activation and biological functions which are cell type ligand and contextspecific moreover recent results from our laboratory suggest that nutritional stress conditions also affect ahr activity the detection of ahr activation in tissues mainly relies on the quantitation of ahr target gene expression however until recently the context specificity of ahr target gene expression had impeded systematic investigation of ahr activity across human cancers our team has developed a pantissue ahr signature that detects ahr activity irrespective of cell type or ligand and enables the analysis of the biological functions mediated through ahr activation the combination of the ahr signature with iterative cycles of computational biology analyses and laboratory experimentation puts us in a unique position to investigate ahr activation and its downstream effects cancahr will hence systematically delineate how the ahr is activated in cancer why ahr activation is cell typespecific and which ahr downstream mediators drive clinical outcomes the identification of the molecular mechanisms underlying the diverse outcomes of ahr activation in cancer will enable i the identification of patients in which ahr activation contributes to clinical outcome ii the development of clinical interventions tailored to the specific mechanisms of ahr activation and iii stratification of patients to precision therapies modulating ahr activity
mystical italy the contested side of holiness

worshipped contested abandoned this downward spiral marked the fates of dozens of mystics and aspiring saints who lived in italy in the first half of the twentieth century neglected today by the majority of the faithful condemned by the ecclesiastical authorities and ignored by scholars the memory of these figures risks falling into the haze of history and with it also the devotional practices and popular cults developed around them by forgetting them we are renouncing any understanding of a significant part of the lived religion of the recent past as well as ignoring the heterogeneous dimension of venerations shaped from below vox populi and the importance of minority and marginalised groups such as emulators of holiness in contemporary catholicism following this path means flattening research to the dominant narrative vox cleri and feeding the main historiographical mainstreams based on the topdown perspective officially approved saints and politicised cults against this scenario mystical italy the contested side of holiness quasisante aims to go beyond the institutional and formal approach to the religion to focus on the popular and potentially contested dimension of holiness through the analysis of aspiring saints who during their lifetime attracted veneration and suspicion and catalysed public attention through quasisante we will get innovative insights into 1 the ordinary peoples perception of holiness 2 the features that mystics had to embody or the skills they had to display to gain the social reputation of living saints 3 the devotions judged problematic for the clergy 4 and how the media science and authorities religious civil and medical fit into these dynamics supporting or opposing them quasisante will develop scientific articles international workshops a database on contested holiness social and multimedia content and an exhibition aimed at the scientific community and a wider audience
estimation of the prehistoric population of eurasia based on a large number of records

understanding population trends over the past 12000 years is crucial for unraveling the complexities of social development population size influences social structures exchange systems environmental interactions cultural transmission and societal resilience current global population figures derived since the 1970s are educated guesses based on limited data and deductive methods hindering accurate prehistoric assessments regional studies emerging data sources and innovative methods offer new possibilities exemplified by the xronos database a significant contribution from our research groupthe ester project proposes a groundbreaking approach employing hierarchical bayesian modeling and data assimilation techniques to integrate heterogeneous big data into population development models this method evaluates data reliability compensates for missing information and facilitates regionalized estimates balancing varying data availability focused on europe and western asia from 12000 to 2000 bp the project aims to provide the first bigdatabased regionalized population estimate subprojects investigate climatic shifts societal collapses and the impact of innovations like agriculture on population dynamics the project aligns with ester boserups theories reflecting her positive vision of humanity capable of changethe ester project introduces a novel methodology offering valid bases for investigating cultural and social configurations dependent on population numbers it provides confidence intervals 50year temporal resolution and absolute population numbers these results can test causal relationships with climatic changes and volcanic eruptions beyond archaeology they offer indicators for human impact and land use aiding various palaeosciences in investigating humanenvironment relationships with unprecedented quality and reliability fostering awareness of our past and its connection to ongoing global change
island ecosystem ecology from deep prehistory to the anthropocene

humans are fragmenting ecosystems into habitat islands causing an unprecedented global collapse of large mammal populations just as science is discovering their essential ecological roles the impact of these losses is such that our understanding of the contemporary biosphere is clearly shaped by a world artificially depleted of terrestrial giants however the causes of megafaunal extinctions over a much deeper 50000year timeframe remain strongly contested how did specific anthropogenic andor climate factors interact to transform and collapse megafaunal ecosystems and what implications did this have for human societies at different points in time the feedbacks and ecological legacies of these older extinctions have important lessons for the current biodiversity crisis yet the dearth of good quality fossil and contextual data from many regions settings and species has prevented robust appraisal islandlab will explore these questions using the maltese islands as a frame of reference for the effects of anthropogenic ecosystem fragmentation pilot work has already uncovered an unprecedented deeptime record of pristine natural systems successively interrupted by waves of humans direct interaction between humans and the endemic megafauna begins with a likely neanderthal presence and ends with the first monumental civilizations with exponential losses and subsequent faunal reintroductions lasting until the midholocene by building highresolution ecological climatic and archaeological characterisations of malta before and after human arrival and subsequent alteration of biotas islandlab will therefore document longterm legacies and feedbacks between ecological changes societal responses and ecosystem resilience more broadly the results will shed light on extinction processes in current anthropogenic landscapes elucidating the ecological and human dimensions of restoration pathways from an island paradigm at a pivot between europe and africa
deciphering signalling pathway dynamics during cellfate commitment in stem cells

understanding the identity and intensity of the specific extracellular signals that a cell experiences at different times during its differentiation is essential to develop advanced cellular therapies however uncovering the sequence of these signaling events their intensities timing and relevance in development and disease is proving to be very challenginghere i propose to build isignaltrace a crisprcas9based molecular recorder with the capacity to store both lineage information and signalling pathway activity for multiple signals over time in single cells by performing kinetic experiments and mathematical modeling i will use isignaltrace to extract the probability of signalling pathways to be activated in stem cells when subject to different extracellular signals and reconstruct the lineage tree of pathway activities during differentiation with singlecell resolution in combination with singlecell rna sequencing isignaltrace will make it possible to characterize transition and intermediate states along differentiation trajectories and quantify the integration between extracellular signals and autonomous programs of gene expression these results will allow predicting the differentiation trajectories that stem cells follow when subject to external perturbations and deciphering the role of heterogeneity in signalling pathway activity during cellfate commitmentusing isignaltrace i will identify missing or redundant signalling pathways induced during in vitro differentiation protocols therefore i expect that exploitation of isignaltrace will allow establishing new criteria to design protocols to differentiate stem cells on demand as a proofofconcept i propose a framework to improve the functionality of monolayerderived cardiomyocytes taken together i signaltrace will find applications in both fundamental developmental biology and translational regenerative medicine which will benefit a much wider scientific community
polymer informatics tools for sustainable 3d printing

polymer informatics supports sustainable development goals by implementing versatile computational tools which allow users to move the polymer design from the laboratory to the digital worldto connect the links between the structure properties and performance of the polymer materials many pieces of puzzle need to be collected over a wide range of time and length scales starting from the quantum and progressing hierarchically towards continuous methods due to their relative novelty systematic bottomup approaches for biodegradable polymers are in short supply owing to their rich structure stemming from the natural origin they need to be simulated with a great detail what leads to an increased computational complexity and researchers frustration consequently the computational studies struggle to keep pace with the emerging applications and technologies such as additive manufacturing pits3d project aims to speed up the progress in the field by proposing a systematic bottomup study of two biodegradable polymers widely used in 3d printing techniques the atomistic description of the local processes of the selected samples represents the first pillar of the approach in the second stage the computational study is extended to longer time and length scales while going beyond the stateoftheart by mimicking the characteristics of commerciallyproduced biodegradable polymers by providing the simulation input files as opensource starting packs pits3d aims to encourage the further development of these computational tools another objective is to bridge a gap between the theoretically studied systems and those used for the 3d printing by establishing an iterative passage of properties between the computational and experimental techniques the combination of both approaches optimizes the use of resources providing economic and ecological benefits and represents a unique training opportunity for the fellow as well as for the students of the host institute
aienabled tactical fmp hotspot prediction and resolution

various air traffic flow and capacity management atfcm measures are implemented during the pretactical and tactical flow management phases to resolve traffic congestion aka hotspots however these are generally based on flight plan data on the day of operation an aircrafts actual trajectory may differ significantly from its flight plan and as a result hotspots still occur and these have to be resolved by air traffic controllers atcos without sufficient advance notice with todays atfcm tools tactical air traffic control atc hotspots are only identified up to around 20 minutes in advance the aim of astra is to bridge the gap between the flow management position fmp and the planner controller working position cwp by developing a aibased tool to trl2 for fmp personnel which can predict and resolve hotspots earlier than today before they are within the scope of the sector planner the objectives of the project are to a develop an fmp function to predict hotspots at least 1 hour in advance and to propose strategies to resolve them b develop human machine interface hmi concepts to allow interaction between operators and the tool and c demonstrate and validate the tool by conducting humanintheloop realtime simulations rts in a representative operational environment the benefits of this tool would include increased capacity at atc unit level better adherence to efficient and green business trajectories reduced atco workload and more predictable operations the project will be carried out by a multidisciplinary consortium of 5 partners from 4 countries malta spain italy and switzerland including an academic institution an ansp an air traffic management atm technology provider and two consultingresearch entities the partners are complementary to each other and bring a combination of academic technical human factor and operational skills and expertise to the project
piloting novel costcompetitive bifacial ibc technology for vertical integrated european gw scale pv production value chain

the ibc4eu project will develop cost effective and sustainable bifacial interdigitated back contact ibc solar cell and module technology on pilot line level based on business cases from the whole value chain ingot wafer cell and module we will demonstrate that ibc technology is the most promising choice for a fast launch of gw scale pv production in the eu cost competitiveness not only against future heterojunction hjt and tunnel oxide passivated contact topcon technology but also presentday perc and perc technology will be demonstrated for the polyzebra and polo ibc cell designs to reach this goal costeffective production equipment will be developed and ecodesign approaches will be employed to reduce the need for scarce materials such as silicon metal and silver and to maintain indiumfree design pilot lines interlinked on all levels of production will help to reach gw scale mass production not only on cell but also on ingot wafer and module level until 2030 the advantage of the chosen ibc technology is that it is based on existing production technology thus the project will focus on improving existing processing steps on already available equipment introducing some novel equipment to reduce the cost of ownership and employing industry 40 solutions for predictive maintenance quality control and traceability the feasibility of the chosen technologies and the innovative products will be evaluated by businessrelated parameters as well as performance characteristics which will be tested according to the relevant standards and in demo sites the environmental impact will be monitored closely and ecodesign approaches will be used to reduce the co2 footprint increase the resource efficiency and recyclability and improve in terms of circularity potential
development of an organic photovoltaic module that generates energy from ambient light

lithiumion batteries libs are one of the most important electrochemical energy storage system for iot devices in 2015 56b libs were sold worldwide however lithium mining is extremely damaging to the environment and it harms the soil and causes air contamination furthermore the typical estimated life of a lib is about very short 23 years or 300 to 500 charge cycles whichever occurs first dracula technologies has developed the layer the green alternative to libs the layer is an opv module produced through inkjet printing that generates energy from ambient light and that is specifically designed for iot devices such as smart home tools it consists of 2 electrodes2 interfacial layers and the active layer made of organic raw materials semiconducting organic molecules or polymers fullerene derivatives nonfullerene derivatives it is less than 5mm thick and its power conversion efficiency pce under outdoor and indoor illumination is respectively 12 and 25
deciphering the internalization profiles of mglu receptors

g proteincoupled receptor gpcr are membrane proteins targeted by around 30 of all marketed drugs gpcr internalization is a mechanism that tunes the cell surface versus intracellular receptor ratio a parameter that plays an essentig proteincoupled receptor gpcr internalization is a mechanism involved in the tuning of cell surface versus intracellular receptor ratio a parameter that plays an essential role in controlling receptor physiological responses this process is very well described for many gpcrs but surprisingly not for metabotropic glutamate receptors mandatory dimeric gpcrs that are ubiquitously expressed in the brain to regulate neuronal transmission deciphering which are the internalization pathways related to mglus emerge as a strategy for the regulation of their response to not only drugs but also endogenous neurotransmittersi propose to examine the internalization profiles of mglus in brain cells and to unravel the structural and molecular mechanisms involved in the process i will use a biophysical technique optimized by the host team that allows the realtime and quantitative measurement of receptor internalization in both recombinant cells and brain cells in combination with a microscopy approach that will complement the analysis on top of that i will use nanomolar range affinity nanobodies single domain antibodies that have already been developed by the host team as a tool for ultimately elucidate which are the internalization profile of mglus in brain cellsas a consequence of this project the internalization profile of mglus in neurons and astrocytes and the cell machinery responsible for this process will be clarified for the first time this knowledge will allow the finetuning of mglus localization in the cell as well as the validation of the nanobodies as a tool for studying endogenous mglus these outcomes will upgrade the current resources that the scientific community has to modulate mglu receptormediated responses
sepsis diagnosis via integrated breath sensing system with changepoint detection for realtime pointofcare

every 28 seconds someone dies from sepsis 11 million people annually out of which children under 5 years old septic shock is the potentially fatal bodys dysregulated response to pathogens that spread through blood circulation including viruses like sarscov2 half of sepsis cases happen in icus with 42 morality with costs of 30 000 per case and 20 billion per year current diagnosis protocols rely on observation of the clinical symptoms to initiate regular monitoring of patients vital signs blood analyses and other tests identify the source of infection within 25 days during which broadspectrum antibiotics are administered contributing to antibiotic resistance every hour of delay increases the mortality rate by 510 hence early diagnosis of the infection source is a major step towards treatment preclinical and commercial pointofcare devices reduce the analysis time to few hours but still rely on the manifestation of clinical symptoms and invasive bloodbased assays sepsisensor will advance the sepsis diagnosis protocol by noninvasive realtime monitoring of icu patients breath to detect presymptomatic signs of sepsis based on transient changes of gas biomarkers in early sepsis stages this will be achieved by a integrating commercial gas sensors with fabricated preconcentrators on a single chip for high sensitivity efficient and scalable multiple gas sensing b using online changepoint detection cpd on the breath signal to identify temporal variations of single and multigas concentration c validating the system with gases released from in vitro and in vivo models of sepsis sepsisensor will go beyond the stateoftheart by reducing diagnosis time and in turn reducing time in icus cost and sepsis fatalities this aligns with pillar i excellent science msca fellowship under the european research council and key strategic orientation a with cluster 1 of the work programme on technologies for healthy society
scale smart charging alignment for europe

scale will enable and facilitate the mass deployment of electric vehicles and the accompanying smart charging infrastructure to do so scale will systematically assess customer expectations identifying evusers preferences existing obstacles and potential incentives to charge smartly by this scale ensures cocreation and optimisation preparing for an open smart charging v2x ecosystem that equally benefits users cities regions businesses and society at large scale brings together leading existing research innovation initiatives and smart charging demonstration testbeds from across europe forming a unique knowledge collaboration platform the consortium builds upon existing technologies standards and protocols as much as possible and focuses on research and developments of the missing andor incomplete elements and links the 29 project partners and associated organisations have been carefully selected and have all the necessary scientific practical and technical expertise to develop test validate and exploit smart charging v2x solutions partners cover the entire value chain and comprise of leading european oems dso tsos cpos emobility service providers public authorities research knowledge partners ev user associations and european networks multipliers multiple scale consortium partners are directly involved in ecs european alternative fuels observatory other important european emobility initiatives stf clean bus europe scale creates a critical mass to develop the technological regulatory organisational and legal readiness that is needed for a massmarket scale will initiate a joint european procurement for v2x chargers based on open standards run by 5 european cities the open v2x alliance ensures scales legacy during and after the projects lifetime