Dragon09/odtu_chatbot huggingface dataset:
a 21st century approach to study chytrid fungal infections in an amphibian hybrid zone

worldwide declines in amphibian populations have led to many local and global extinctions and are connected to the global spread chytrid fungus bd because few animals survive infection bd poses a strong selection pressure in infected populations hybrid zones where two species meet and reproduce are an ideal setting for research on adaptation as different combinations of gene variants are tested however two contrasting hypotheses exist on the role of hybridisation in infection resistance genetic incompatibilities between diverging populations limit gene flow between closely related species and cause lower fitness in hybrids thus the first hypothesis postulates that the negative impact of pathogens is higher in hybrid zone populations than in populations comprising a single species the second hypothesis proposes that the resistance of a hybrid population towards pathogens is strengthened by the coexistence of multiple immune gene variants in comparison to populations comprising a single species the two species of yellowbellied and redbellied toads bombina are an ideal system to investigate these hypotheses as 1 their hybrid zone has been wellstudied before using various but few genetic markers and 2 toads of these species have previously been found to be infected with bd on a side note the skin microbiome of amphibians is different between healty individuals and individuals infected with bd to date little is known about the interaction between bd infection and the skin microbiome and even less is known about this effect in bombina with this action i aim to investigate the role of hybridisation in pathogen resistance in amphibian populations i will also explore changes in composition of the amphibian skin microbiome in response to bd infection i will use the genus bombina as a model system employing 21st century sequencing technology
palliative care yields cancer wellbeing support

challenge many patients with advanced cancer in the final phase of life leave the hospital without continuity of information and certainty about further treatment and care provision often communication between healthcare providers in different settings is suboptimal and this leads to poor continuity and coordination of care negatively impacting the quality of life and increasing preventable hospital admissions solution the palcycles programme a transitional palliative care programme for patients with advanced cancer adaptable to local cultures and healthcare systems the programme contains an intervention aiming for a smooth transition from hospital care to community care consisting of five cornerstone components 1 identification of a patient with palliative and supportive care needs in collaboration with the oncologist and the hospital palliative care team 2 compassionate communication towards the patient and their family 3 a collaborative multidimensional care plan and followup in the home care setting 4 periodic evaluation of the care plan with patients and relatives 5 identification of the terminal phase if there based on the periodic evaluations with appropriate intensification of care and endoflife talks depending on local possibilities and habits including consultation with patient and families about ethically and legally sensitive issues plan we intend to develop adapt implement and evaluate the palcycles programme in seven european countries using a stepped wedge randomized controlled trial design patient relatives and health care provider experiences as well as ethical and equity issues will be addressed with qualitative methods impact the palcycles programme will facilitate patientcentred communication and continuity of palliative cancer care in the community care setting reducing unplanned hospital admissions and improving quality of life for patients with advanced cancer at the end of life
autonomous aerial inspection of gnssdenied and confined critical infrastructures

the 50k large vessels across the world must be regularly monitored for corrosion and defects by human surveyors including dangerous and dirty confined gnssdenied areas such as ballast water tanks and cargo holds one person is killed every week from accidents in these enclosed spaces which despite having large surface areas consist of many smaller confined compartments with narrow passages 40cmx60cm however a radical new approach is possible using unmanned aerial systems uas or drones by combining the latest developments in 1 collisiontolerant uas 2 multimodal slam 3 path planning 4 autonomous drone racing 5 aerial manipulation 6 miniaturized ndt sensors and 7 mlbased defect identification only through a complete integration of these technologies is it possible to address the challenges of deploying aerial robots in these challenging conditions equipped with automated aibased scanning mapping navigation and contactbased ndt this has the potential to completely remove the need for human inspection using a digital twin approach brings superhuman results comprehensive semanticaware detailed 3d mapping 1 cm resolution of large structures 300 m high resolution visual and ndt analysis 100um and improved traceability with automatically generated trend analysis the ml for system mapping and ndt is trained with sociotechnical inputs from experienced human inspectorscurrently a typical inspection costs 1m and requires 15 days 8 days inspection and 7 days travel to low cost far eastern docks a uasbased inspection will take 1 day with 12 days travel to an eu port at a cost of 200k saving the industry 9b pa with 24mt of co2 reduction this consortium includes many of the world leaders in the field of uasbased inspection teamed with vessel owners and inspectors enabling an endtoend survey solution which would save 50 livesyr and provide safer more reliable and accurate inspection data
toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders

since the ancient egyptians the fluid in the brain has been considered a product of spirits a pathological signature or inert liquid even at the turn of the 19th century when the cerebrospinal fluid csf was first described as a physiological substance the csf and the interstitial fluid isf the fluid surrounding all the cells of the brain were considered solely as a cushion only more recently studies have begun to show that the compositions of these fluids can have a marked impact on brain development and animal behaviour a number of studies have employed omics to demonstrate that the isf and the csf are rich in secreted proteins rnas and metabolites however it is still unclear how these factors influence the development and the function of the brain here we will take a systematic approach to advance our knowledge about the role of extracellular proteins in the brain in health and disease using knowhow in studying the causes of autism spectrum disorders asds my lab will study the effects of changes in the composition of the extracellular space of the brain at unprecedented resolution and scale specifically we aim to 1 functionally identify proteins of the extracellular space that modulate neural development 2 study proteins that are packaged into extracellular vesicles and whose mutations are considered high asdrisk factors 3 analyse in vivo the function of hnrnp u an rnabinding protein which we identified in brain extracellular vesicles and whose mutations are tightly linked to neurodevelopmental disorders this endeavour will represent an important step toward a better understanding of the role of extracellular factors in brain development and function my work will highlight an entire class of protein encoding genes that crucially contribute to neural development by a previously underappreciated pathway ie through the extracellular parenchyma and that when altered lead to forms of asds which may be more amenable to treatment
mechanosensitive proteins as a pathway to mechanotargeted drug delivery

biophysical research over the last two decades has revealed that an impressive number of mechanical signals are key regulators of cell behavior so far the focus has been on understanding fundamental mechanosensing and transduction mechanisms in health and disease as increasing numbers of molecular players and signalling pathways are identified the time has come to utilize this knowledge for diagnosing and treating diseases where mechanical processes play a role in this proposal i aim to target integrins to deliver reporter molecules and drugs to cells with a distinct mechanical phenotype integrins are transmembrane receptors through which cells can sense transmit and discriminate biomechanical forces during cell adhesion and migration integrins engage with specific ligands in the extracellular matrix and undergo integrin recycling through continuous endo and exocytosis this known endocytic pathway integrin clustering during adhesion and overexpression in disease states has made integrins a prime target for drug delivery however the chemical and physical factors governing integrinmediated uptake of drugs and their intracellular fate are unknown i propose to utilize molecular force sensor mfs technology to deconvolute the key factors in integrinmediated drug delivery using rational protein design a series of coiled coil mfss with distinct chemical charge and hydrophobicity and physical mechanical and thermal stability properties will be produced the molecular constructs will be appended with the integrintargeting rgd motif a fluorescent protein to investigate the intracellular fate and an actinbinding protein as a model drug that may potentially interfere with the cytoskeleton architecture this mfsbased drug delivery system will enlighten the pivotal factors of integrinmediated delivery provide a diagnostic assay for discriminating cells based on their mechanical phenotype and open up the road towards mechanotargeted drug delivery
aiinformed holistic evs integration approaches for distribution grids

the ahead aiinformed holistic electric vehicles integration approaches for distribution grids project will create a simulation environment capable of predicting the most convenient location to place the electric vehicle ev charging stations and optimise both the usage of the power grid resources and the charging stations located in urban and rural areas this simulation environment will exploit the unique features of currently available ai models and include two layers the spatial mapping one placing the chargers where the people need them to be and the power grid one placing the chargers where the grid can support them innovative smart charging algorithms will be designed and tested in the model to minimise the impact of ev charging pools on the network and ensure the consumers have economic benefits moreover these smart charging algorithms will be tested in three demonstration sites dedicated to assessing the technical and economic feasibility of smart charging light and heavyduty evs and boats to this end ahead gathered relevant partners from all the ev valuechain technology providers who want to test their equipment in the real world grid operators who want to optimise the usage of the grid resources and mitigate the ev charging impact and research institutions who aim at advancing the knowledge on the topic and producing value for society particular attention is going to be placed on the user experience and cybersecurity part of the demonstrators with specific partners who focus their efforts on understanding how to minimize the impact of smart charging on the user experience and on creating a model to represent cyberattacks on the chargers to suggest efficient defensive mechanisms for system protection
chirality and spin selectivity in electron transfer processes from quantum detection to quantum enabled technologies

chirality is a key property of molecules important in many chemical and nearly all biological processes recent observations have shown that electron transport through chiral molecules attached to solid electrodes can induce high spin polarization even at room temperature electrons with their spin aligned parallel or antiparallel to the electron transfer displacement vector are preferentially transmitted depending on the chirality of the molecular system resulting in chiralityinduced spin selectivity ciss the longterm vision of the castle project is to transform the ciss effect into an enabling technology for quantum applications this will be accomplished by achieving four key objectives 1 the occurrence of ciss will be studied at the intramolecular level by photoinducing rapid electron transfer within covalent donorchiral spaceracceptor molecules to generate longlived radical pairs rps 2 direct detection of rp spin polarization will be performed using timeresolved and pulsed electron and nuclear magnetic resonance techniques in addition polarization transfer from one of the radicals comprising the spinpolarized rp to a stable molecular spin q will be used to initialize the quantum state of q making it a good qubit for quantum applications particularly sensing 3 quantum mechanical studies of the ciss effect will provide predictive models for molecular qubit design 4 the ciss effect will be used to control readout and transfer information in prototypical devices embedding hybrid interfaces based on semiconducting or conducting substrates thus dramatically advancing the use of molecular spins in quantum information technologies targeting hightemperature operation these devices will be used also to prove moleculebased quantum error correction the knowledge acquired with castle will impact a wide range of fields including magnetless spintronics dynamic nuclear polarization for nmr signal enhancement catalysis and light harvesting
unravelling the impact of radiofrequency in liver surgery the key to decrease local recurrence

colorectal cancer crc ranks fourth in cancer deaths worldwide between 20 and 30 of patients with advanced crc have liver metastases crlm liver cancer ranks second in cancer deaths worldwide including hepatocellular carcinoma hcc despite recent advances liver resection offers the only chance of cure for patients with liver metastases however the recurrence rate of these tumours is high even after postresection the presence of positive margins in the remaining liver after resection correlates with increased local recurrence and decreased overall survival the only factor where prognosis could be influenced by the performance of surgery however at present the extent of an rnegative status remains debatable and varies widely from one publication to another currently there are radiofrequency ablation studies that based on preliminary retrospective human clinical trials are able to correlate an additional coagulation of tumor margins with a reduction on local recurrence however there is no prospective and pragmatic controlled study that accurately measures this additional margin and its impact on oncological outcomes the aim of liveration is to conduct an ambitious pragmatic multicenter clinical trial with 720 patients with crlm and hcc at 24 clinical centres in 6 different countries to determine whether additional ablated margin produced by radiofrequency can decrease the recurrence rate and improve patient survival we will also evaluate the patientcentredness of the intervention and its comparativeness with other therapeutic alternatives in terms of quality of life and patient experience in realworld settings to this end the consortium has been formed by highly experienced highly qualified and multidisciplinary entities to carry out the project successfully the results will not only have a major impact on a social and scientific level but also on an economic level for the eu this action is part of the cancer mission cluster of projects on diagnosis and treatment
highpressure nitride materials towards the controllable and scalable synthesis in a diamond anvil cell

over the past decade a branch of solidstate inorganic chemistry has emerged that aims the discovery of novel atypical compounds at highpressure conditions nevertheless the need of modern technology in new materials which are available only from the highpressure synthesis can be fulfilled only if these materials are produced in measurable quantities via a controlled and reproducible process within hipmat i will focus on the synthesis of nitride materials a class of compounds with outstanding and diverse physical and chemical properties which find applications as ultrahard materials as well as in semiconductor technology the overarching aim of hipmat is to address the challenges of highpressure synthesis which lie beyond simple material discovery we will use new opportunities provided by the european xray free electron laser for studying mechanisms of highpressure nitridation reactions using the combination of pulsed laserheating and ultrafast xray probing knowledge of the reaction mechanisms and kinetics will allow to choose reaction conditions favoring maximum amounts of desired products next we will focus on the upscaling of the synthesis of the most promising highpressure nitrides by developing novel precursors and by performing the synthesis in newly developed largevolume diamond anvil cells hipmat will not only result in the discovery of plethora of novel highpressure materials but also will provide deep understanding of mechanisms underlying the chemical synthesis at highpressure conditions and will enable controllable largescale synthesis of new functional materials the methods developed within hipmat will be applicable to other classes of materials and will be an important contribution to the field of solidstate inorganic chemistry and materials science
geometric analysis and surface groups

we propose to study links between curves in flag manifolds surfaces solutions of geometric partial differential equations in some affine symmetric spaces and functions on the moduli space of curves we will consider the relevant energy functions on the moduli spaces of those curves or on the moduli space of anosov representations for periodic data in particular in the context of positivity amongst our concrete ambitious goals are obtain topological invariant through quantising anosov deformation spaces define and compute volumes of anosov deformation spaces and prove recursion formulae for them find surfaces in symmetric spaces associated to opers and the relevant higherrank liouville action solve special cases of the auslander conjecture using foliated spacesmore specifically the backbone of this project is to explore a general class of functions on moduli spaces of anosov representations and beyond of uniformly hyperbolic bundles then we propose to identify the family of curves that will be possible asymptotic boundaries in the spirit of quasisymmetric curves in the sphere the periodic ones corresponding to anosov representations we will prove the existence and uniqueness of surfaces bounded at infinity by these curves going back we will consider the area of such a surface both at critical points on the moduli space and as a renormalising function allowing to consider volumes of these moduli spaces finally we will consider the space foliated by surfaces solutions of the asymptotic datum and define entropy
advanced remote continuous patient health management solution

patients die because deteriorations are missed there is a huge unfulfilled need for better patient monitoring diagnostics and reaction everywhere in healthcare a reason is that despite advancements with remote monitoring devices the current care model still relies on short snapshots examinations which leave a lot of dangerous conditions missed untackled or tackled too late at checkpointcardio we are enabling the switch from a snapshot model to a full movie model where patients and carers are fully and constantly connected we have set up the first of its kind 247 remote observation medical centre that thanks to a wearable device and the use of ai constantly monitors and manages healthcare delivery for more than 50 000 critically ill patients already saving hundreds of lives we now want to replicate the model for patients suffering from chronic diseases multiplying both our business opportunity and the impact we have on peoples lives
investigating virusinduced morbidity in filarial infections

filarial parasites cause over 200 million infections globally filarial morbidity was presumably limited to the skin eyes and lymphatic vessels however my research generated evidence that onchocerca volvulus infection also induces neurological disease including onchocerciasisassociated epilepsy oae however the causal mechanisms for neurological symptoms linked to o volvulus infection are still unknownrecently my research group codiscovered a virus ovrv1 within o volvulus being related to the rabies virus family ovrv1 could potentially cause oae i will investigate the clinical implications of this virus in 1600 persons from 3 affected countries casecontrol studies will verify whether ovrv1 is a risk factor for oae in a cohort study of onchocerciasisexposed children with neurological symptoms i will investigate the presence of ovrv1 in cerebrospinal fluid and assess its neurotoxicity by seeding ovrv1positive samples on neural organoids viral metagenomics on mansonella perstans most common filarial disease 110 million infections will determine if it also harbours ovrv1 or other viruses finally i will establish a prospective pregnancy cohort n900 and followup their children to investigate the maternofoetal consequences of in utero exposure to filarial parasites andor virusesthis project is expected to unveil new disease mechanisms and may lead to new diagnostictreatment options if ovrv1 is shown to be associated with oae it could serve as a biomarker to diagnose this condition however if ovrv1 is found to be an o volvulusspecific endosymbiont it could be used to improve the performance of the current onchocerciasis diagnostic tests it could even become a target for the development of new macrofilaricidal drugs demonstrating that filarial infections can adversely impact pregnancychild health will justify research on safe approaches to treat pregnant women and underfives with ivermectin during mass drug administration
conductive minerals as electrical conduits in methane cycling

this proposal aims to gain a fundamental understanding of the impact of anthropogenic conductive particles on methane emissions we recently showed that conductive particles are vital for the interspecies crossfeeding of a methaneproducing consortium from the baltic sea previous to that we showed that conductive particles accelerate methane production in synthetic dualspecies consortia that typically function via direct electron transfer others showed that conductive particles may also stimulate anaerobic methane oxidation for the latter the reports are scarce and contradictory it is mysterious how microorganisms interact with the conductive particles and how conductive particles affect the methane cycle in the environment these knowledge gaps we will study here we will use synthetic consortia enriched environmental consortia and whole sediment cores we will identify marker genes for microbeparticle contacts by combining expression studies with targeted genedeletion and physicochemical cell surface studies the marker genes we can then use to track similar microbeconductive particle associations in the environment we will examine the link between increased anthropogenic particle input and methane emissions in environments from the mediterranean to the arctic where higher particle input is likely i expect to deliver fundamental knowledge about the microorganisms involved in methane transformations by anthropogenically derived conductive particles