Dragon09/odtu_chatbot huggingface dataset:
photo switchable activation of sigmahole

governing intermolecular interactions is crucial for i controlling how molecules communicate within a molecular assembly and ii finetuning the physical and chemical properties of ordered materials halogen bonds xb and chalcogen bonds chb are two sigmahole interactions that are garnering significant attention across various fields such as supramolecular chemistry crystal engineering anion recognition and catalysis owing to their directionality and strong predictability among the numerous factors influencing the molecular organization of interacting partners interaction strength plays a significant role its increase or decrease is pivotal in activating or deactivating recognition phenomena current strategies to optimize the recognition process are limited to strongly activated xbchb donors the switching onoff reversible control of xb and chb interactions has never been explored and could have valuable implications in virtually all fields where these interactions occur this seems to be the next essential challenge in the realm of sigmahole interactions and will be addressed by halo halo aims to a photoinduced manipulation of the inherent electrostatics of heavier halogenchalcogen atoms to toggle their involvement in electrophilenucleophile interactions on or off b exploit this control over interactions to develop new strategies for timehonored recognition processes eg sensing of toxic anions like cn no2 aso43 while sigmahole interactions have been known for decades their photochemical activation has not been addressed until now notably the hydrogen bond the most utilized molecular interaction across interdisciplinary fields does not offer any means for such electrostatic control the breakthrough of this project lies in introducing reversibility to the stateoftheart xbchbbased recognition strategies paving the way for a new generation of xbchbbased lightresponsive materials for green processes and devices
gravitational interferometry with entangled states in optical fibers

the four known interactions that occur in nature can be described either by einsteins general relativity or by quantum field theory over the last decades physicists have tried to put these two pillars of modern physics on a common foundation in doing so they have been limited by a lack of experiments at the interface of these two frameworks both theories have been independently verified with astonishing precision but all verifications to date have come without drawing on concepts from the other theorythe goal of gravites is to perform experiments at the interface of quantum physics and general relativity for the first time we will measure gravitational properties of single and entangled photons in the background of einsteins gravity to this end gravites aims to combine four complementary disciplines quantum photonics and precision interferometry guided by expertise in general relativity and quantum field theory the synergy among the research groups will realize a largescale fiber interferometer with unprecedented precisionsince the sensitivity of gravitess apparatus must exceed present largescale fiberbased quantum interferometers by orders of magnitude the two experimental teams must combine cuttingedge technologies in their respective fields for advancing singlephoton interferometry these developments are also of direct relevance for many other applications such as quantum metrology and quantum sensing in parallel the theory teams will investigate the combined effects of gravitation and field quantization in dielectric waveguideswith this united effort gravites is in the position to explore new physics that determines the gravitational properties of quantum superposition and quantum entanglement this will allow us to create a unique experimental platform for probing how gravity interacts with the quantum world
developmentalities islamic and islamist views of state society and economics in yemen

how applicable are economic development models approaches and policies of the eu to the ideational political and structural conditions of middle eastern societies this project provides answers to this question by examining islamic and islamist views on state society and economics in yemen the poorest country in the mena region the project contrasts divergent ideas of development among yemens islamistsinexile focusing on the houthis the salafis and members of alislah living in turkey saudi arabia the united arab emirates 8ua and oman comparing local developmentalities with those prevailing among western donors it leverages the momentum of the slowdown of hostilities enabled by the recent iransaudi deal and the ongoing saudihouthi negotiations through an innovative methodology that combines concepts and approaches from oral history ethnography economics and politics academically the project breaks new ground in the field of islamic and islamist economics by enriching our understanding of how political actors in the global south think about state modernity globalization and capitalism it thereby contributes to yemens history since 2011 while enriching our understanding of mena geopolitics with new subaltern perspectives of the southern arabian peninsula it further sheds light on the intersectionality between the epistemic universes of western development theory and practice and its applicability and receptivity in a complex wartorn society that is dominated by tribalism and power politics the secondary objective is to make a tangible contribution to the eus current efforts to transition beyond humanitarian and towards economic forms of development policy by creating an unofficial line of communication between yemens islamists and eeas officials the project intends to yield pragmatic and actionable policy outcomes while adding a critical but constructive perspective on the eus current development efforts in yemen
a path towards ethical spectatorship

the project a path towards ethical spectatorship will analyze ethical approaches to media consumption developing a theory and a practice of individual ethical engagement with entertainment crucially this will be addressed from the perspective of the audience member rather than society at large so displacing the traditional focus on the ethics of the author of the content grounded in 20th and 21stcentury philosophical and sociologic analyses of the ways in which meaning is constructed found and extracted from the materials we read listen to and consume a path towards ethical spectatorship will build upon the researchers decadelong work on inheritance and legacy in the cultural space adapting the framework of reception theory to the sphere of contemporary entertainment media the project will create a new model for the critical discussion of ethical spectatorship for secondary schools that will be presented to two of the schools involved in the access ucc plus programme upon analysis of the results of these activities the model lesson plan on ethical spectatorship will be perfected and made available to schools beyond cork as well as to members of the general public in their lifelong learning the goal is to provide terminology and conceptualization to help the audience make sense of instances of cancel culture author denunciation and cultural boycotts and to understand whether these correspond to a responsibility of the individual audience member as they participate to the development of an inclusive and peaceful society
solving conformal field theories with the functional bootstrap

conformal field theories cfts have a wide range of experimental and theoretical applications describing classical andquantum critical phenomena where they determine critical exponents as low or high energy limits of ordinary quantumfield theories and as theories of quantum gravity in disguise via the adscft correspondenceunfortunately most interesting cfts are strongly interacting and difficult to analyse on the one hand perturbative andrenormalization group methods usually involve approximations that are hard to control and which require difficultresummations on the other hand numerical simulations of the underlying systems are difficult near the critical point and canaccess only a limited set of observablesthe conformal bootstrap program is a new approach it exploits basic consistency conditions which are encoded into aformidable set of bootstrap equations to map out and determine the space of cfts a longstanding conjecture states thatthese equations actually provide a fully nonperturbative definition of cfts in this project we will develop a groundbreakingset of tools analytic extremal functionals to extract information from the bootstrap equations this functional bootstraphas the potential to greatly deepen our understanding of cfts as well as to determine incredibly precise bounds on thespace of theories our main goals are a to fully develop the functional bootstrap for the simpler and mostly unexplored onedimensional setting relevant for critical systems such as spin models with longrange interactions and line defects inconformal gauge theories leading to analytic insights and effective numerical solutions of these systems and b to establishfunctionals as the default technique for higher dimensional applications by developing the formalism obtaining generalanalytic bounds and integrating into existing numerical workflows to obtain highly accurate determinations of criticalexponents
open music europe openmuse an open scalable datatopolicy pipeline for european music ecosystems

openmuse brings together music industry stakeholders and researchers from 11 eu countries and ukraine our consortium recognises that placing european music ecosystems on a more competitive fair and sustainable footing requires evidencebased policymaking business planning and accuracy we provide the data needed for these actions using transparent methods and tools openmuse maps the policy and data landscape bridges data gaps and empowers stakeholders and policymakers to take datadriven actions our project is grounded on principles of open policy analysis open science and opensource software development we work with stakeholders to identify data gaps on the eu national and regional levels cocreate indicators and methods for bridging them develop free software tools for data collection and analysis and report not just our findings but every step taken to reach them this is the logic behind our open music observatory omo an opensource platform that provides 360degree intelligence on the music industry by integrating numerous data sources the omo is highly automated providing living policy documents that refresh when the backend datasets are updated these datasets include official statistics on music goods and services data on musical participation via paneuropean surveys rightsholder data voluntarily shared by industry partners and streaming service data sampled using novel algorithms developed by our consortium using the omo and our opensource software music msmes without technical departments or expertise will be able to access and analyse open data model volume and value including of zeroprice uses create better business models and generate corporate social responsibility and sustainability reports all at a fraction of current costs we validate these tools in four pilot studies that will bring concrete benefits to stakeholders within the project lifespan
hidden metastable mesoscopic states in quantum materials

nonequilibrium states of matter have become of great fundamental and practical interest in recent years because of their wide importance in diverse areas of physics with the rapid development of new timeresolved techniques the temporal dynamics of competing processes and interactions were recently elucidated in a wide variety of complex condensed matter systems however the physics of metastable mesoscopically nonperiodic quantum textures emerging from phase transitions has been largely experimentally inaccessible till now current state of the art timeresolved methods using xrays electron diffraction photoemission thz and optical spectroscopy all average over multiple transition outcomes moreover they cannot resolve irregular nonperiodic nanoscale structures thus a large field of mesoscopic quantum physics of metastable quantum states remains largely unexplored here we propose to develop a unique set of tools to investigate mesoscopic metastable irregular textures created under controlled nonequilibrium conditions in quantum materials with focus on topological transitions and quantum jamming phenomena temporally tempered excitation techniques combined with timeresolved scanning tunnelling microscopy will be used to studying single and multiple transition outcomes with atomic spatial resolution on timescales from picoseconds to hours experiments supplemented by new theoretical approaches will address the creation processes relaxation dynamics and quantum decoherence of metastable mesoscopic structures as well as manipulation and control theoretical approaches for addressing resulting quantum states include fractonderived models and quantum annealing on a quantum computer the project opens the path to detailed exploration of a new class of physical phenomena of wide fundamental interest in different areas of physics while opening new avenues in nonequilibrium solid state quantum systems technology
identifying molecular features of potent antibody and memory bcell responses associated with rtss malaria vaccine efficacy

malaria is the most important parasitic disease being a leading cause of death among young children particularly in subsaharan africa in the context of the world health organization who strategic goals for a world free of malaria there is a strong need of highly efficacious vaccines despite the rtssas01 rts vaccine candidate was recently approved for use in african children it demonstrated a modest efficacy during phase 3 clinical trials hence a better understanding of the determinants of longlasting immunity induced by the rtss is required to support improved nextgeneration vaccines aiming to provide the maximum coverage to target populations in this regard previous serological analyses demonstrated that high antibody levels and avidity are associated with vaccine efficacy in african children recipients however the molecular mechanisms and the cellular immune phenotypes supporting such potent antibody responses have not been fully deciphered to fill these knowledge gaps we propose to develop an indepth humoral immunoprofiling within the large multicenter rtss phase 3 clinical trial using already collected samples from african children participants by generating a collection of antigenspecific monoclonal antibodies i will investigate the molecular features of the rtssinduced memory bcell response and the most relevant target epitopes in parallel i will identify the lymphocyte populations mobilized upon highly responding serological profiles to subsequently develop a multivariable analysis integrating clinicalepidemiological serological and cellular datasets to elucidate hallmarks of potent antibody responses and vaccine efficacy
roman making and its meanings representations of manual creation in the literature and art of imperial rome

how did the ancient romans respond to the material world around them this project facere proposes a new way of approaching this question it studies making the processes by which the objects and buildings which surrounded romans in their daily lives were produced how things were made in ancient rome is usually studied as a practical or technical process however making also has a wide range of culturally specific aesthetic and moral implications facere breaks new ground by asking not how making was done but what making meant to the inhabitants of the roman empire to answer this question we analyse the roman discourse of making literary texts poetry and prose in greek and latin and visual art works such as paintings reliefs and mosaics which represent processes of making and can tell us how romans thought felt and spoke about them facere aims to achieve two key objectives first we will write a new cultural history of roman making adding to our understanding of the technological logistic and economic dimensions the crucial new dimension of the cultural values involved in making in particular its aesthetic and moral complexities how did making relate to roman notions about the environment how did roman writers and artists depict the ability and agency of different kinds of makers and how does this relate to their gender ethnicity and social status were certain ways of making considered superior to others and why second facere proposes a new way of investigating the impact of material culture on roman viewers how things were made and how their stories of making were presented or imagined was deeply relevant to what they meant to their ancient viewers owners and users facere introduces the innovative analytical concept of madeness which allows us to bring making and meaning together
business plan optimisation and preparation for scaling of a transcatheter heart valve replacement manufactured using automation

lifelet medical is on a mission to deliver one valve for life for patients suffering from heart valve disease lifelet is developing a disruptive polymeric heart valve replacement to transcend the limitations of mechanical and animal tissuebased devices available to patients today combining the durability of mechanical valves with the blood compatibility and minimally invasive delivery of animal tissue valves lifelets fully synthetic device aims to enable improved patient outcomes and reduced complications with easier deliverability enhanced durability and cost savings for healthcare systems through automated manufacturing and processingthere are 12 million patients in the us with severe aortic valve stenosis and over half of these patients are symptomatic requiring a heart valve replacement the transcatheter aortic valve replacement tavr market size is 4b expected to growth to 7b by 2024 with a doubledigit cagr thanks to recent clinical trials indications are being expanded for younger patients asymptomatic patients and those at low and intermediate risk for surgery driving growth of the market cardiologists will lifelets device with existing reimbursement in place as a platform technology the lifelet polymer may also offer clinical benefits in the treatment of obesity gastrointestinal diseases and incontinence elle sander female ceo and cofounder is a biomedical engineer who has led the company to a proofofprinciple in chronic sheep studies and is a lead inventor of the material technology with one patent granted in the eu already cofounder and cmo dr faisal sharif consultant interventional cardiologist has a trackrecord of implanting new devices and a extensive experience of clinical trial development and operations the team have a passion to commercialise this deep tech and have the vision to execute on what is required from technical clinical regulatory and commercial perspectives
metamorphosis of cultural heritage into augmented hypermedia assets for enhanced accessibility and inclusion

shift is strategically conceived to deliver a set of loosely coupled technological tools that offers cultural heritage institutions the necessary impetus to stimulate growth and embrace the latest innovations in artificial intelligence machine learning multimodal data processing digital content transformation methodologies semantic representation linguistic analysis of historical records and the use of haptics interfaces to effectively and efficiently communicate new experiences to all citizens including people with disabilities the development of shift tools will be carried out in close consultation with the stakeholder communities represented in the project the two ch networks bmn anbpr will launch open consultation to aggregate views from their members while together with the cultural heritage institutions somkl smb and heritage professionals heritage management will provide requirements based on the cultural assets being maintained within each organisation the diversity of digital media transformation and the semantic formalisation of the cultural assets will be individually demonstrated across each museum and library additionally the inclusion by design principles adopted within the project will be evaluated by ch networks and vulnerable group partner dbsv who will engage with the various tools developed in the project in complementary to the stakeholders and endusers the shift project also brings together leading industrial simavi and academic institutions forth uau qmul the consortium is complemented by smes mds aud with hightech product development teams and ethical expertise erc collectively the project will release 12 technology solutions clustered into five thematic areas computer vision audio texttospeech haptics semantics and linguistics that support accessibility and inclusion by design to overcome the shortcomings and limitations of cci sector to enable growth and stimulation
development of reconstructed electron energy loss techniques for elemental mapping in macromolecular structures

a perfect macromolecular structure would provide an allatom description of the molecule including not only the wellordered polypeptide or polynucleotide framework but all other species metals and other ions cofactors lipids substrates and inhibitors however current structural data include no or very little information on elemental composition leading to significant errors and omissions in atomic models to address this issue i propose to develop a method reconstructed electron energy loss elemental mapping reelem that will map elemental distribution within macromolecular complexes by bringing together wellestablished principles in analytical electron microscopy em and biological cryogenic ematomicresolution elemental mapping in the electron microscope is well established for dosetolerant samples electron energy loss eel techniques capture information from inelastic scattering events in the sample and energy losses are characteristic of the element and chemical state of the scattering atom these techniques require a high electron dose to achieve useable signaltonoise ratio severely limiting their application to biological samplesour novel approach combines the image processing tools of singleparticle cryoem with eel techniques allowing us to add eel signal in the 3d particle space effectively dividing the dose required for sensitive elemental analysis between many images preliminary work in my research group confirms that our proposed approach is valid we are able to generate maps of specific elements in the 3d particle space i propose to extend this early work to achieve singleatom detection at 1nm spatial resolution in the course of this fiveyear project our work will characterise and optimise all aspects of data collection and processing for reelem we will apply our methodology to two important macromolecular complexes the skeletal muscle ryanodine receptor and the mitochondrial ftype atp synthase