Dragon09/odtu_chatbot huggingface dataset:
science from the large scale cosmic microwave background polarization structure

observational cosmology is moving towards its next major milestone highprecision measurements of the cosmic microwave background polarization with the goal of detecting and characterizing the primordial bmodes these polarization patterns would provide a unique picture of the early universe shedding the light on the conditions at that time be it cosmic inflation gauge fields or more exotic possibilities in a regime of energy where standard models are expected to break such observations could revolutionize our current picture of cosmology and high energy physicscharacterizing such signal requires 1 reaching extremely low instrumental sensitivity levels and 2 controlling instrumental and astrophysical systematic effects with unprecedented fidelity while 1 is about to be reached with the planned deployment of funded cuttingedge observatories such as the simons arrayobservatory cmbs4 and litebird 2 is already limiting the current constraints and will be studied and uniquely mitigated by scipolmy project is an opportunity to claim a leadership role for europe in one of the most active and impactful research areas in physics complementing the hardware efforts led by the us and japan i will construct accurate opensource and versatile models for the instrumental astrophysical signals and noise properties develop and exploit new general algorithms adjusting previous models from observations and producing a unique set of instrument and foregroundcorrected maps make a statistically robust cosmological inference of these especially on the large scale implementing a gravitational lensing correctioni have been at the forefront of this research for the last 10 years made key contributions to the analysis and scientific exploitation of the polarbear data sets and to preparations and scientific optimization of the forthcoming efforts i am consequently uniquely positioned to deliver the objectives of the proposed work
nanoengineered particles for enhanced cancer radiotherapy

current cancer research efforts are focused on obtaining targeted therapies with greater precision that lead to improved patient survival with fewer adverse effects to ensure a better quality of life encant nanoengineered particles for enhanced cancer radiotherapy will contribute to this aim by developing new therapeutic agents based on biocompatible nanoparticles bearing high atomic number z elements which will enhance external beam radiotherapy ebrt effect on cancer tissue this will allow the use of a lower radiation dose consequently lowering adverse effects related to radiotherapy lack of specificitythe physicochemical properties of the nps can be rationally designed according to different needs nps will be functionalized to increase their blood circulation time and facilitate their accumulation in the tumoural tissue nps will be tested in vivo to describe toxicity ranges targeting efficiency and their therapeutic effect with external beam radiotherapy using in vivo cancer modelsencant will initially focus on highz nps for prostate cancer pc nevertheless their adaptability should allow to use them for other tumour types thus expanding their range of application encant aims to improve and expand oncology treatment options available to cancer patients thus providing them a more personalized treatment
innovative artificial intelligence methodologies for monitoring and maintaining large scale complex infrastructures and obtaining greener more resilient and smart societies

over the past 2 decades the use of artificial intelligence ai has exponentially increased toward complete automation of structural inspection and assessment tasks this trend will continue to rise in image processing as unmanned aerial systems uas and the internet of things iot markets are expected to expand at a compound annual growth rate of 575 and 26 respectively from 2021 to 2028 it is generally accepted that ai will drive the next revolution in autonomous inspection and health monitoring of civil infrastructure the possibility of complete automation of the inspection process resulted in a lot of attention from the scientific community leading to a plethora of research in this area fourier intends to establish a network of individual research projects working towards breaking through and innovative system state monitoring stm techniques via the use of ai for largescale autonomous systemic monitoring inspection and proactive testing including respective explicit identification of information gaps and uncertainties information quality of complex engineering systems to improve their resilience against failures accidents sabotage disruptions and disasters the objective of fourier is to offer innovative research training as well as knowledge exchange opportunities for doctoral candidates dcs through crossborder and crosssector mobility for future growth in europe fourier is an intermultidisciplinary and intersectoral programme as it includes seven academic partners three research centers and seven private companies and two end users from seven different european countries
a pragmatic clinical study of neoadjuvant chemotherapy followed by surgery versus surgery alone for patients with high risk retroperitoneal sarcoma

retroperitoneal sarcomas are rare diseases refractory to treatment with dismal prognosis surgery is the only standard approach to primary disease we are proposing an innovative pragmatic approach supplementing a standard phase iii clinical trial with an observational cohort it is proposed to amend the ongoing phase iii eortc clinical trial strass2 investigating the added value of neoadjuvant chemotherapy before surgery for highrisk retroperitoneal sarcoma and to add an observational arm strexit2 that will capture real world data from patients not participating to strass2 we will compare the clinical outcomes between strass2 and strexit2 and explore the possible combination of strass2 and matched strexit2 patients to strengthen the results of the randomized clinical trial data and increase the power of subgroup analyses if conclusive the proposed research will help to understand the clinical added value and costseffectiveness of neoadjuvant chemotherapy before surgery for highrisk retroperitoneal sarcoma we will perform health economics analysis assessing the economic value of different treatment scenarios based on strass2 and strexit2 if successful the outcomes of the project will define a new evidencebased standard of care for highrisk retroperitoneal sarcomas the proposed research could lead to improved patient survival and quality of life but also improving health system sustainability this is a multidisciplinary and multistakeholder consortium involving clinical oncologists surgeons health economists and patient representatives the study design was successfully discussed with patients this action is part of the cancer mission cluster of projects on diagnosis and treatment
resilient enhancement for the silicon industry leveraging the european matrix

the general objective of project resilex is to demonstrate 7 industrydriven technological and business innovative solutions covering the full silicon value chain in order to contribute to improving the resilience and sustainability of this critical raw material value chain in europe resilex resilient enhancement for the silicon industry leveraging the european matrix will assess the economical social and environmental impact of these solutions and identify roadmap provide open source policymaking recommendations to accelerate the replication of the ones with the highest potential while also addressing transversal challenges from the european mining industry as a whole with a 8th pilot transversal demonstration
phytobacterial vesiculation regulation cargoes and function

phytopathogenic bacteria are of substantial economic importance threatening the quantity and quality of food production reducing crop losses from disease epidemics caused by bacterial pathogens is critical for the supply of agricultural produce on the other hand colonisation of plants with beneficial bacteria can stimulate plant growth by increasing the nutrient uptake by roots or prime plants for enhanced defense against biotic and abiotic stresses which can help to improve or bring new approaches to efforts to reach sustainable agriculturecelltocell communication which is ubiquitous in all biological systems plays a critical role in plantbacteria interaction recently it has been considered that one of the significant ways to achieve celltocell communication is through extracellular vesicles evs these cytosolcontaining membrane spheres provide selection storage and protection against degradation of enclosed cargoes in a highly dynamic and environmental cueresponsive manner evs also offer the opportunity for directed cargo delivery to dedicated recipient cells and serve as a quick adaptation strategy to react to a changing environment 1this project proposal aims to shed light on the vesiculation process of phytobacteria and the role of evs in plantbacteria interactions the missing detailed understanding of vesiculation and evs properties is a critical gap in our complete knowledge of celltocell communication especially in plantbacteria interactionsat its completion this project will lead to new insights into the crucial tool celltocell communication contributing to the virulence of pathogenic phytobacteria and the mechanism for how bacterial symbionts promote plant growth and fitness
cochlear implants and spatial hearing enabling access to the next dimension of hearing

the loss of inner hair cells in the cochlea causes deafness since the first trial of a cochlear implant in 1957 cochlear implants have been developed to the point where they can rerestore hearing and speech understanding in a large proportion of patients although spatial hearing is central to controlling and directing attention and to enabling speech understanding in noisy environments it has been largely neglected in current implants matching of binaural information a basic prerequisite for spatial hearing is not yet implemented furthermore intensive rehabilitation programs are lacking the here proposed interdisciplinary doctoral network in which physicians psychologists and engineers collaborate aims at the improvement of spatial hearing in cochlear implant users in ten different interconnected projects spatial hearing will be improved by 1 applying machine learning algorithms to identify sounds sources and to provide the information to ci users through visual or tactile spatial cues 2 examining physiological impairments of spatial hearing in ci users and matching the imbalance of the binaural inputs and by 3 patientcentered training programs that make use of virtual environments the doctoral training network will provide the next generation of researchers and engineers that will have a good understanding of the multifaceted problems of spatial hearing and that will be equipped with expertise and skills to come up with innovative solutions in this field the collaboration between academia and the private sector enables the realisation of new solutions for spatial hearing with cis thus enabling deaf patients to substantially improve their hearing
cold sintering process for fabrication of biodegradable drugeluting ceramics

drugcer proposes a paradigm shift in drug delivery for bone restoration by making drugs an inherent part of a biodegradable ceramic implant such a new approach would require drug loading during ceramic sintering which in turn requires multidisciplinary research and development of lowtemperaturecold ceramic processing accordingly the main research goal of drugcer is to apply a novel pressureassisted cold sintering process csp for cosintering of biodegradable ceramics with drugs to achieve the goal the researcher will receive advanced training in csp and develop the cosintering process by establishing a relationship between the processing parameters and properties of the resulting bioceramics she will train in and master cryofocused ion beam milling and cryoscanning transmission electron microscopy to investigate the process kinetics and densification mechanisms finally she will train in and develop methods for complex shaping to adapt the method for potential translation to preclinical studies coldsintering will decrease energy consumption in bioceramics fabrication it will also enable bioceramic cosintering with other temperaturesensitive materials eg polymers opening paths to innovations in fields beyond orthopedics or even medicine eg construction ceramicsmultidisciplinary supervising teams at fraunhofer ikts host and penn state university secondment will support training through research and transferrable skills development grant writing teachingmentoring project management networking and horizontal skills intersectoral communication with charit hospital short visits will ensure highquality guidance in developing prospective biomedical technology from its very beginning thus drugcer will equip the researcher with unique expertise skills and a professional network for establishing an independent group in the niche of lowtemperature energyefficient ceramic processing
european data as a product value ecosystems for resilient factory 40 product and production continuity and sustainability

as part of the green circular and digital transformation of the european manufacturing community it is extremely important that datadriven digital manufacturing processes urgently incorporate innovative and active resiliency strategies at production and supply chain levels to maintain their sovereignty and competitiveness levels respecting european digital values excellence privacy trust to improve individual and value chain flexibility in order to achieve longterm resilience to reorganise supply chains or speed up decision making to dealt with any disruption it is imperative to ensure the implementation of distributed dataintensive intelligent and dynamic industrial decision support augmentation and automation processes integrating artificial intelligence smart anticipation and intelligent automation rapid response capabilities in humanautomation symbiosis hence only businesses that can articulate their data based on ai digital thread and digital twin solutions will be able to react rapidly to external shocksre4dy mission is to demonstrate that the european industry can jointly build unique datadriven digital value networks 40 to sustain competitive advantages through digital continuity and sovereign data spaces across all phases of product and process lifecycle proposing data as a product core concept to facilitate the implementation of digital continuity across digital threads data spaces digital twin workflows and aimldata pipelines this concept leverages resiliency on top of advanced manufacturing digital processes and value ecosystems supporting the development and implementation of digital continuity so distributed data management solutions implemented to deal with factory resiliency can be immediately and seamlessly reused to enhance connected factory and value network level processes
a new approach to sustainable development of airport and seaport territory through citizen science hubcities

airport and seaport territories are special types of areas they are hubs centers of transport or transshipment activities and centers of territories and networks that consume resources land water and air in europe there are 347 airports and 3024 seaports the challenges they face are at the heart of the eus policy frame of referenceconfirmed for example by the driving urban transitions partnership which guides muchneeded urban change toward a sustainable future these challenges are addressed by a novel approach the main aim of the project is to train a new profile of urban planner that is able to use citizen science in such difficult urban planning situations engaging residents in codesign citizen participation and citizen science is a bottomup approach that is still underused in applying a bottomup approach any further spatial development of these territories would include the perspectives of their inhabitants thus an important step would be taken toward a longterm spatial future strategy to be better understood these territories need to be named as hubcities and decoded as an urban resource three supporting instruments will make it possible to develop a methodology hubcities platform as a communication instrument hubcities labs as an event engaging citizens and hubcities toolkit as a planning tool for citizens the paradigm shift caused by such an approach would be applicable in practice research and education three selected hubcity regions will serve as a testbed the airport and logistics center of graz austria networked passenger airport at the koper seaport slovenia regional passenger airport of trieste port city italy as a result of the project my career prospects as a researcher will grow decisively i will become the leading figure in adapting urban planning procedures with citizen science approached by colleagues and actors for transfer of the skills acquired and highquality planning solutions
alternatives for an effective transition to sustainable reusable and recyclable construction products by the innovative production of user and ecofriendly biobased materials

the building and construction sector is a key area that has significant impacts on the economy and environment this sector contributes to the economy about 9 of the eus gross domestic product gdp provides direct and indirect job opportunities 18 million direct jobs at the eu and satisfies the peoples needs for buildings and facilities therefore any effort concerning global climate change and cleaner production should include this industry as a major playeratrium exploits the potential of combining natural fibres leftovers of european crops mainly hemp second and third generation of bioplastics biopepapu and myceliumbased biotechnology to produce biocomposites intermediates that can be integrated in construction products outdoor and indoor floorings acoustic panels green wall systems and building block to be easily used by professionals and amateurs in building and renovation actuations in this way atrium will not only provide more safety and nontoxic construction solutions but also boost the creation of sustainable biobased value chains and the integration of efficient biotechnology to develop the circular economy and bioeconomy sectors to do this atrium will develop production pilot lines that integrate efficient and flexible technologies coextrusion foaming injection moulding additive manufacturing and biofabrications and engage the key actors for the design acceptance and certification of the new products atrium will also promote the public engagement dialogue to bring the eu closer to citizens and local urban and rural areas through appropriate communications local initiatives and actions
location location location the repositioning of regulatory elements in the mammalian genome

in mammalian genomes the enhancers e that control a promoter p are often scattered over tens to hundreds of kb and frequently interdigitate with es that control other nearby ps how such apparently haphazard linear arrangements can result in specific gene regulation is a major puzzle three main constraints are thought to be involved first biochemical compatibility of es and ps may ensure that not all ps respond equally strongly to a given e second chromatin loops may either facilitate or curb particular ep interactions third es and ps are controlled by the local landscape of chromatin modifications much is still to be learned about these constraints and their interplay to unravel the logic of this linear arrangement of ps and es it is necessary to systematically alter the positions of es ps and elements that control looping so far no efficient method has been available for this purpose we propose to develop and apply relocate a scalable broadly applicable technology to transplant selected dna elements to hundreds of alternative positions within a 2 mb region and track the functional consequences we will employ relocate in combination with a highthroughput combinatorial reporter assay to systematically study how biochemical compatibility may dictate how es choose and activate the correct target ps furthermore we will adapt relocate to precisely map how loop extrusion shapes ep interactions by insertion of hundreds of unidirectional road blocks throughout a locus finally we will use the method to finemap the repressiveactivating chromatin landscape of selected regions at high resolution and elucidate how es and ps may respond differently when inserted throughout this landscape this work will reveal how the ordering and spacing of regulatory elements along the genome contributes to optimal gene regulation and will yield a powerful perturbation tool with many applications in genome biology and human genetics
supervised mechanisms for locomotor learning in the cerebellum

motor learning is essential to move in a continuously changing environment but the underlying neural circuit mechanisms are still poorly understood this is critical for locomotion a fundamental but complex behavior which requires precise control of wholebody movements at the same time the cerebellum plays a key role in motor learning supposedly generating corrective movements through supervised errorbased mechanisms in response to perturbation for simple tasks climbing fibers originating in the inferior olive drive supervised learning generating changes of cerebellar activity and corrective responses during locomotion perturbations cause gait asymmetries which can be externally induced in a splitbelt treadmill with belts running at different speeds the host laboratory developed a splitbelt treadmill to study locomotor adaptation in mice showing that it is similar to humans occurs through motor corrections with complex spatiotemporal dynamics and is driven by the cerebellum however the underlying neural bases are unknown superloco aims to identify supervised mechanisms for locomotor learning exploiting the synergy between cuttingedge technologies to interact with neural circuits and computational neuroscience tools specifically we will i record climbing fiber and cerebellar activity during locomotor learning in mice with highyield electrophysiology ii simulate locomotor learning in a bioinspired spiking neural network of the cerebellum with climbing fibersupervised plasticity iii optogenetically stimulate climbing fibers to induce locomotor learning based on model predictions our main hypothesis is that the timing of climbing fiber signals determines changes of cerebellar activity through supervised plasticity driving locomotor learning superloco outcomes will shed light on neural mechanisms for complex wholebody movements fundamental in neuroscience and crucial for treatment of movement disorders