Dragon09/odtu_chatbot huggingface dataset:
future proofing health and care systems safeguarding health care workers in hospital settings

background healthcare professionals working in hospitals and those in training to embark on hospital careers experience high levels of stress especially in the surgical pathways while interventions to improve wellbeing and resilience exist not much is known about the right combination of interventions for this specific setting aim keepcaring aims to rebuild wellbeing and resilience of healthcare workforce in eu hospitals by cocreating a multifaceted nondigital digital and aisupported solution package to prevent burnout among aspirant healthcare professionals on the individual team and organisational levelapproach our multisector and interdisciplinary consortium will 1 study stress and stressors experienced by aspiring health care providers in their specific setting 2 evaluate digital and nondigital solutions to reduce stress at an individual and team level 3 study job crafting among aspiring health professionals as a way to reduce stress and 4 finally develop a change management platform that using explainable ai helps hospital managers as well as surgical caregivers to choose the solutions that match their context all solutions as well as the portal will be developed in cocreation with end users including 2 professional associations in our consortium in addition legal and ethical expertise is provided across partners and in advisory board to ensure privacy and ethical guidance in this sensitive context impact keepcaring will provide solutions to improve wellbeing among health care professionals and students thereby reducing burnout and improving the number of health care students entering the workplace our organisational solutions will empower individuals and employers to understand and act on stressful situations in their specific setting costeffectiveness analyses will be used for policy recommendations to ensure sustainable uptake among policy makers funders and employers
scriptural networks digital exploration of quotation culture in origen of alexandrias exegesis

in the ancient world knowledge production was based on the use of quotations so much so that scholars commonly refer to it as quotation culture this culture of quoting extended across various ancient civilizations including greek near eastern hebrew and chinese societies early christian communities were no exception as their theologies were drawn from the biblical texts analysing their citation patterns is essential in unravelling their thought processesmy project aims to redefine our understanding of early christian quotation culture by employing digital network analysis na techniques applied to the extensive works of the renown theologian origen of alexandria 3rd century origens focus on biblical interpretation and his enduring influence makes him an ideal casestudy i will conduct an analysis of origens whole corpus using na graphs and social network analysis thus uncovering relationships and patterns within his biblical quotations by looking at origens use of biblical quotations as sets of interconnected relations the project seeks to investigate how he derived his theological doctrines particularly his doctrine of religious freedom from the bible the proposed na methodologies have never been applied to ancient texts representing a groundbreaking approach that opens new research directions into the study of quotation culture this innovative methodology holds promise not only for the study of early christianity but also for a wide range of textrelated disciplinesin collaboration with au department of theology and the centre for humanities computing chc the project will achieve two objectives o1 develop a novel digital approach for studying quotation culture resulting in the creation of an openaccess and opensource custombuilt graph database for visualizing clusters of biblical references in origens work o2 explore the concept of religious freedom in origens work using the newly developed na methodology
nextgeneration of interior models of exoplanetsstudying the interior structure of giant planets and its effect on their evolution atmospheres and observations

the prevalence of metals in exoplanet atmospheres is considered an important tracer of the formation of gas giants however the current theoretical framework is founded on the critical assumption that such planets are composed of a core surrounded by a homogeneous and wellmixed envelope recent data from cassini and juno show differently resulting in a paradigm shift in the interiors of jupiter and saturn jupiters envelope is now shown to be nonhomogeneous leading to new pathways for studying the interactions between giant planet interiors with their atmospheric constituents this new knowledge desperately needs to be incorporated in exoplanet studies this is the aim of nginewe are in a unique time for this study we have extraordinary data to study the giants in the solar system and the jwst will provide exceptional data on exoplanets atmospheres now is the time to gather the stunning amount of exoplanet data and the detailed insights supplied by our solar system and get integrated knowledge coming from all giant planetsi have unique expertise in these fields to fill this gap and lead a team of 3 phd students and 2 postdocs to work at the frontier of exoplanets and solar system science we will provide the community with the first opensource retrieval tool for exoplanet interiors based on my stateoftheart models for jupiter use jwst to compile the first database on refractory species in exoplanet atmospheres indicating the solids accreted during formation study atmosphereinterior interactions with selfconsistent atmospheric radiative transfer and interior models and go beyond the stateoftheart with new interior models for jupiter saturn uranus and neptune with nonhomogenous interiors and using neural networks the impact of the new interior models developed in ngine will also affect atmospheric chemical and retrieval calculations revolutionizing the way of interpreting observations in exoplanets and learning about their origins
differential effects of dietary potassium intake on blood pressure

as the primary risk factor for the onset of cardiovascular disease hypertension is a major contributor to premature death and disability high dietary sodium na consumption is often considered a primary culprit for hypertension but evidence exists that increasing dietary potassium k consumption may lower blood pressure bp however a number of studies in humans indicate that higher k intake is not always beneficial for blood pressure effects that the host lab recently confirmed in rodents reducing and maintaining a lower bp based on dietary intervention requires understanding of the long term andor accumulated effects of the intervention and the underlying molecular basis this project will increase our understanding of the differential effects of dietary k on bp the role of the kidney and potentially the vasculature the project objectives are to 1 determine the optimum dietary k intake that reduces and sustains lower bp 2 identify factors in the kidney that drive k sensitivity of bp 3 assess if sustained high dietary k intake changes vascular function 4 investigate the molecular basis of any vascular remodelling that promotes or is consequential to increased bp during prolonged high dietary k intake to address these questions i will apply a broad range of interdisciplinary skills and methods telemetric monitoring of bp in vivo assessment of kidney and vascular function in animal models and gene modified mice rna sequencing including singlecell and bioinformatics optical clearing and innovative 3d multiplex imaging of tissues successful completion of the research in this proposal provides an excellent opportunity to uncover new targets and strategies for the management of hypertension from a personal perspective it represents a major step towards establishing myself as an independent researcher in the area of renalvascular crosstalk
epithelial exchange surfaces from organizing principles to novel culture models of the gatekeepers of the body

epithelia are sheets of interconnected cells that cover the surfaces of our body and internal organs they form physical barriers that protect our body from external insults and control the exchange of materials with the outside to perform these functions epithelial cells establish a specialized apical top exchange surface that faces the exterior defects in epithelial functioning contribute to many diseases such as cystic kidney diseases inflammatory bowel disease and susceptibility to infection moreover loss of epithelial organization is a hallmark of invasive tumourssurfex will tackle two urgent interlinked problems that hamper progress in combatting epithelial diseases 1 the need for highlyskilled scientists who can bridge basic research in small model organisms and cell culture with translational research using advanced 3d culture models that mimic the organization and physiology of human epithelia and 2 the need to improve our understanding how the apical exchange surface is formed and functions in health and diseasesurfex brings together academic and private partners from 8 european countries to establish a multidisciplinary intersectoral training and research programme that will study how epithelial cells form a functional apical exchange surface surfex unites fields ranging from genetics to materials science microfabrication and advanced 3d cell culture techniques this provides an opportunity to train doctoral candidates in a unique combination of experimental approaches and methods including breakthrough organoid and organonchip technologiestight collaboration with nonacademic partners will strengthen the technological base of different projects and provides the fellows with insights into the translation potential of the studies and career development opportunities in biomedical industry extensive training in transferable skills will round off the training of the fellows into creative critical and autonomous professionals
an advanced surveillance platform to improve the european multi authority border security efficiency and cooperation

security risks and threats in the maritime domain are becoming increasingly more complex day by day within the eu there have been significant increases in irregular migration flows and human trafficking and smuggling but also of other illegal activities such as drugs and arms trafficking and illegal unreported and unregulated fishing and according to the frontex risk analysis for 2021 report the challenge becomes even bigger the european union maritime security strategy and other eu initiatives such as eurosur and cise highlight that closer collaboration between authorities at national regional and eu levels can constitute the key action to increase both situational awareness and operational efficiency in particular there is increased interest in assessing the viability of multiauthority cooperation in especially high altitude sensing and capability advancement for enhanced wide area surveillance of land air and sea borders eurmarss groundbreaking vision is to expand the common risk assessment practices currently deployed by authorities to enable the development deployment and evaluation of a secure multitasking surveillance platform that improves sensing capabilities for a wide range of security risks and threats in wider border areas by clustering high altitude platforms technology satellite imagery uxvs and groundbased sensors into a novel joint surveillance capability as part of the eurmars framework the various existing and future systems for maritime surveillance will be integrated to allow for the collaborative operation and the provision of the sensing results to related authorities the open architecture will build on the lessons learnt of previous initiatives assimilate the knowledge of the stakeholders and their practice on cise and other relevant systems exploit the latest ai risk assessment and visualization innovations and undergo extensive technical and user acceptance tests and ethical and legal impact assessments
a training network for the design of synthetic carbohydratebased vaccines in the fight against multidrug resistant nosocomial pathogen acinetobacter baumannii

bacterial infections are a societal burden with profound medical and socioeconomic impacts although antibiotics can be effective the continuous emergence of bacteria with antimicrobial resistance calls for the introduction of novel therapeutics in this regard glycoconjugate vaccines gv hold a prominent role in the fight against amr bacterial strains they are based on the chemical conjugation of one or more pathogenassociated saccharide antigens to immunogenic carriers leading to a longterm protective immunity acinetwork will focus on the development of gv against severe and lifethreatening infections caused by antimicrobial resistant acinetobacter baumannii strains which are a major cause of nosocomial diseases and for which no vaccine exists acinetwork wants to overcome the limitations of currently licensed gv due to highly heterogeneous composition and batch wise variability by innovatively using structurallydefined synthetic oligosaccharide antigens to develop gv with welldefined composition higher purity and better safety profiles the manufacturing of such gv is also more rapid and costeffective thus this project will set synthesis and testing pipelines that will serve as the prototype for the development of gv against other bacteria the acinetwork consortium comprises universities and smes with a unique complementary expertise ranging from carbohydrate chemistry to nanotechnology immunology and microbiology which garantees the realization of the new gv the goal of acinetwork is to also forge 10 young experts in the design of these novel medical solutions with an integrated training program which will equip them with a large battery of scientific and transferable skills the multidisciplinarity of the consortium ensures a fertile and stimulating environment in which these young researchers will acquire unique competencies in vaccine design development and production which will be central at putting europe at the forefront of gv
securing local supply chains via the development of new methods to assess the circularity and symbiosis of the biobased industrial ecosystem enhancing the eu competitiveness and resource independence

the symba project aims at creating a new and innovative is method to be replicated within eu according to the localregional biobased industrial ecosystem symba will implement a userfriendly and accessible ai database suggesting regional is innovative processes to create zerowaste value chains ensuring more local supply chains a better distribution of economic and social benefits among the stakeholders and an increase in the economic value of final products symba solution aligned with the eu bioeconomy strategy is based on a threefold approach1creation and validation of new is methodology for the biobased sector starting from existing knowledge and lessons earned from symba consortium partners2individuation of criteria to select regional hubs3ai database including monitoring tools waste relation matrix networking and cooperation with ongoing eu and local networks the partnership has been intentionally selected by its expertise network with key external stakeholders and geographical reach bringing together 5 eu countries it es be nl de to consolidate the maximum outreach of the initiative it consists of 9 partners with complementary competences 4 rtd centers circe ctb aimplas cet 1 large industry nvmt 1 pilot facility bbepp 1 innovative sme enco and 2 networks ckic and iclei with a valuable background in applying is approach in the biobased sector providing services to companies and creating awareness and networking among citizens policy makers eu initiatives through the involvement of different industrial sectors agrifood nvmt packaging aimplas wastewater cet textile ctb waste valorisation bbepp symba will demonstrate how to shift from a linear to a circular economy contributing to deliver biobased solutions with reduced environmental impacts on soil water and air quality
demonstration of sustainable hydropower refurbishment

hydropower and storage capacity need to increase to meet the need for renewable and dispatchable power generation according to iea worldwide hydropower capacity should increase from 1360 gw in 2021 to 15631782 gw by 2030 and up to over 2500 gw in 2050 at the same time hydropower refurbishment projects must implement modern sustainability standards that preserve biodiversity and contribute to climate change mitigation and adaptation the main objective of rehydro is to demonstrate how european hydropower can be refurbished and modernized to be fit for a leading role in the future power system respecting sustainability requirements and societal needs in a climate change context a suite of monitoring and digital tools performance cavitation machine health implemented at demonstration sites will improve hydropower efficiency innovative concepts like retrofitting with pumped hydro and hybridization will make hydropower fit for future marketsrehydro will demonstrate how biodiversity can be improved with new fishfriendly turbines reestablishment of environmental flows and monitored using new tools such as edna smarter use of water resources will also be implemented so that more services can be delivered to the power markets while multipurpose use of the water resources for navigation and recreation can be expanded and the ability to mitigate flooding and droughts is strengthenedthe results from rehydro will achieve all the expected outcomes specified in the call the solutions will give european hydropower industries commercial advantages to utilise the global need for hydropower expansion it is expected that rehydros exploitable results will create 7001150 new jobs in the manufacturing industry increasing the global market by 275 mill eurosrehydro will introduce a new paradigm to boost european leadership and competitiveness in the hydropower industry and provide new sustainable solutions that are replicable at european and global levels
harnessing ammonia reactivity via photoelectrochemical splitting by molecular catalysts

with the global production of ammonia playing a pivotal role in food and chemical industries the nitrogen cycle is essential for sustaining modern life however the challenging nitrogen redox chemistry demand innovative solutions for sustainability harvest aims to advance our understanding of the ammonia oxidation reaction aor by designing molecular catalysts for efficient nh3 splitting with only incipient progress made in aor molecular catalysis harvest will systematically target new iron and manganese catalysts for the aor these will be integrated into dyesensitized photoelectrochemical cells dspec for solar conversion thus harvest not only promises to advance our knowledge on nitrogen chemistry but also holds potential for carbonneutral fuel production and energy storagefor the postdoctoral candidate harvest marks a critical phase in career development with prior multidisciplinary experience the focus now shifts to building a solid profile in molecular electrochemistry and photoelectrocatalysis harvest includes a flexible training program targeting teaching management and supervision roles vital for future research leadership positionsoverall this research not only will advance sustainable technology but will also nurture a versatile and skilled researcher ready to contribute significantly to both academia and industry research units
impact of the gut microbiota on host cells energy metabolism role in health and in inflammatory bowel disease

inflammatory bowel diseases ibd including crohns disease and ulcerative colitis are immunerelated disorders characterized byinappropriate gut inflammation their incidence has increased dramatically in western countries in recent decades supporting a rolefor environmental factors despite the development of new treatments ibd are insufficiently controlled in a large proportion ofpatients inducing an alteration in quality of life and a socioeconomic burden a better understanding of the pathogenesis andidentification of new therapeutic targets are therefore urgently needed in this context the gut microbiota has been recognized as astrong actor in ibd additionally an alteration in intestinal and immune cell energy metabolism has been suggested in thepathogenesis classical hostmicrobe interaction concepts rely on the recognition of conserved microbial motifs by innate immunitysensors or on the action of microbial molecules on a host cell receptor however energy metabolism plays a crucial role in mountingthe appropriate cellular response and emerging data indicate that the gut microbiota may directly affect it i hypothesize that thealtered gut microbiota in ibd contributes to the impairment of host cell energy metabolism and pathogenesis the aims ofenergised are to i identify the microorganisms and microbiotaderived metabolites impacting host cell energy metabolism and themechanisms involved and ii decipher the consequences of gut microbiota alterations on host cell energy metabolism in ibd anddesign new microbiotabased therapeutic strategies to manipulate the host cell energy state in ibdthis challenging project involves multidisciplinary aspects from microbiology to immunology metabolism and medicine the use ofmultiple cuttingedge technologies and translational analysis from mice to humans in addition to its scientific importance it willhave societal impacts due to the identification of new therapeutic strategies
dipolar superfluid of diatomic molecules and boseeinstein condensate of tetramers

dimobecte will explore the rich phase diagram of a degenerate fermi gas of polar molecules near a fieldlinked scattering resonance including the longsought dipolar pwave superfluid of fermionic diatomic molecules the boseeinstein condensate bec of tetermer molecules and the crossovertransition in between for this purpose we will first create a new species of 6li87rb polar molecules in the quantum degenerate regime this new kind of bialkali molecules is promising for its highly tunable interaction and its potential to reach unprecedentedly cold temperature both are essential to realize the dipolar superfluid and the bec of tetramers specifically we will realize a deeply degenerate fermi gas of new species of 6li87rb molecules with flexible control of dipolar interactions via fieldlinked resonances that was recently demonstrated in my group realize and explore dipolar pwave superfluids featuring anisotropic pairing with nonzero angular momentum in polar molecule systems realize and explore the boseeinstein condensate of tetramers which exhibits both strong dipolar and quadrupolar interactions including the crossovertransition from a dipolar superfluid to a tetramer becwe propose dimobecte at an exciting time when degenerate fermi gases of polar molecules have finally become available in experiments including degenerate nak molecules attained in my group it will provide a brand new platform to understand and design unconventional pwave superfluidity with highly controllable interactions and to realize majorana modes in polar molecule systems and therefore pave the way towards topologically protected quantum computation furthermore it will for the first time bring polyatomic molecules into the quantum degenerate regime by creating a bec of tetramer molecules