Dragon09/odtu_chatbot huggingface dataset:
novel fiber cotton coloration for a revolutionary sustainability breakthrough in textile applications

cotton is the worlds most important nonfood crop accounting for 35 of global fiber production but it is environmentally demanding and resourceintensive its production especially the dyeing process pollutes and depletes water and soil resources the current strategies for cotton dyeing still rely on old manufacturing processes that yield large quantities of chemical and water waste thus it is urgent to seek sustainable alternatives to meet acceptable environmental and social standardsthis proof of concept poc project aims to prepare the commercialization of novel molecules able to modify cotton fibers in planta for textile applications providing them with color this innovative approach minimizes chemical waste associated with dyeing plus achieving up to a 90 reduction in water usage through hydroponic cotton growth by growing cotton fibers with builtin colors in hydroponic settings we seek to pioneer a zerochemicalwaste dyeing process while significantly reducing water consumption our innovation addresses the fashion industrys need for distinctive ecofriendly textile products presenting exciting opportunities to meet the growing consumer demand for more sustainable productsfor this endeavor our objective is to craft a diverse set of molecules strategically designed to navigate and surpass inherent biochemical barriers moving forward we will seek to demonstrate the efficacy of these novel molecules on cotton plants simultaneously we aim to evaluate the commercial viability and potential market of hydrocoltons groundbreaking innovation within the cotton value chain we will validate our business model and commercialization plans with the constant engagement of relevant market stakeholders
spectroscopy for strainmodulated terahertz magnonics

motivated by the recent discovery of a giant straininduced blueshift of terahertz antiferromagnetic spin waves magnons in the spinorbit mott insulators sr2iro4 and ca2ruo4 by the pi and his group the spectera project will explore whether strain modulation can be harnessed to confine and guide thz magnons to probe magnetic order and magnon excitations in inhomogeneous strain environments with high energy and momentum resolution we will develop a combination of raman brillouin and resonant xray scattering instruments including a new momentum microscopy facility that will generate momentumspace images of magnetic order and excitations with microfocused xray beams to establish a materials platform for spectera we will use these instruments for surveys of the strain response of different spinorbit mott insulators including compounds with antiferromagnetic order above room temperature the magnetic ground state and excitations of selected model compounds will be mapped out in carefully tailored strain environments in thermal equilibrium followed by experiments to probe their response to controlled nonequilibrium situations including thermal gradients and local excitation of magnons by intense subthz sources inspired by methods developed in semiconductor physics we will pattern strain profiles by electron beam lithography and assess their ability to serve as magnon conduits finally we will explore the interaction of magnons in spinorbit mott insulators with dynamic strain generated by surface acoustic wavesspectera will create a new nexus between the rapidly evolving research fields of terahertz magnonics and correlatedelectron physics and harness the resulting synergies to explore pathways towards a novel architecture of magnonic devices
digitally empowering citizens to deliver the twin transition

the energy transition of homes toward the eu decarbonisation targets involves many options and choices the average citizens cannot navigate this maze and identify the best solutions for them professionals providing relevant services encounter substantial costs in tailoring their services to individual potential customers due to unavailability of essential data from actual households decodit will develop digital services to support citizens on decision making for participated in the energy transition through cocreated services and customer journeys decodit will deliver tools that clearly present concrete personalised comparable propositions to citizens for futureproofing their homes based on federated datadriven services from multiple diverse service providers thus citizens will be able to compare and select the options that best fit their specific situation and personal needs via apps supporting natural language interfaces so that citizens with low energy or digital literacy can benefit also decodit will facilitate financing for the selected interventions through crosssector datadriven loan underwriting approaches to reduce entry barriers for capital providers hence unlocking consumer investment in home upgrades decodit will contribute in shaping the smart energy landscape with critical enablers such as enabling business models and market regulatory conditions project results will be demonstrated in four european countries latvia spain greece switzerland that are very diverse in terms of building characteristics cultural and regulatory frameworks climate conditions economic capabilities etc piloting activities will be held under the supervision of market actors that span the value chain needed for exploitation energy suppliers esco dso energy communities
training alliance for novel microbiomemodulating therapies

talents aims to build up an international programme for interdisciplinary and transsectorial training of 15 doctoral candidates dcs as needed for the next generation of drug researchers research projects are structured in 3 clusters pcs pc1 will investigate the microbiome by transcriptomic and metagenomic analysis of diseases to identify and isolate microorganismsmetabolites for therapeutically modifying the microbiota pc2 will focus on pathoblockers targeting virulence factors as alternative to traditional antibiotics with lower risk of resistance development pc3 will address the delivery needs across biological barriers to achieve efficient and targeted transport to the site of action throughout the pc structure of 15 individual but interconnected research projects we aim to develop and exchange disease models analytical methods and microbiomerelated results by generating knowledge on correlations and causalities between microbiota and disease talents will advance the development of novel microbiomemodulating therapies talents is builds on an earlier joint venture of saarland university university clinics saarland and helmholtz institute for pharmaceutical research saarland to foster transdisciplinary doctoral training between different faculties and institutions in addition talents is intersectorial by implementing a unique supervision structure for each dc with an external expert advisor and translationoriented training for individual career development also including secondments in a complementary industrial or clinical sector working on challenging research projects the candidates will acquire specific knowledge and skills at the interface of clinical medicine microbiology and pharmaceutical science pivotal for stateoftheart infection research and microbiome interventions by collaborations of experts from natural sciences medicine and bioinformatics talents provides highlevel multidisciplinary and intersectorial training
revealing the wiring rules of neural circuit assembly with spatiotemporally resolved molecular connectomics

the human genome contains several thousand genes that play a key role in the development of the brains connectome a precise assembly of neural connections with billions of neurons and trillions of synapses how is genomic information translated into synapsespecific connectivity underlying behavior and cognition answering this fundamental question will provide important insights about the principles underlying nervous system development and is relevant for neurodevelopmental disorders such as autism however current approaches to measure neuronal connectivity have intrinsic limitations that prevent combined analysis of connected neurons and their gene expression profiles at a scale that matches the complexity of the mammalian nervous system here i propose to develop a novel approach for massively parallel neural circuit tracing with barcoded rabies virus and 3d intacttissue rnasequencing this will permit a comprehensive understanding about neural network architecture via the largescale measurement of molecular cellular and circuitlevel mechanisms in the mouse brain compared to current efforts that require vast scientific resources to map synaptic connectivity among a few cells or small tissue volumes my approach will enable routine measurements of connections among thousands of single neurons with molecular detail based on my expertise in in vivo barcoding i will conduct a longitudinal study to reveal the wiring rules underlying the spatiotemporal development of neural circuits from diverse neuron types in the mouse prefrontal cortex a brain region that plays a key role in cognition i will follow a crosssectional approach to unravel the effects of distinct mutations on neuronal wiring in the prefrontal cortex in two mouse models of autism cntnap2 syngap1 my work will provide an innovative experimental platform and provide mechanistic insights into the developmental algorithms that the genome uses to encode the connectome
revisiting the origin of intrinsic cellular autofluorescence in metabolic imaging

metabolic dysregulation is a hallmark of numerous diseases multiphoton microscopy mpm combined with fluorescence lifetime imaging flim of the metabolic coenzymes nadh and fad has emerged as a key method for monitoring metabolic processes in live tissue with subcellular resolution however recent data demonstrates that spectral crosstalk from other cellular components such as keratin is substantial yet the contributions from endogenous proteins are often neglected bringing into question the validity of earlier studies to address this issue we propose to systematically scrutinize the fluorescence properties of nadh fad and keratin in different states and combinations this will be done by meticulous investigation of the fluorescence lifetime spectra and related photophysical properties using mpm and timeresolved spectrophotometry under a range of conditions ph temperature viscosity protein binding and in combination with computational chemistry based on this knowledge we will develop approaches that can accurately determine the concentration diffusion and binding state of nadh and fad even in the presence of spectral crosstalk from keratin the strategy is to implement phasorflim analysis fluorescence lifetime correlation spectroscopy flcs and raster lifetime image correlation spectroscopy rlics to separate the fluorescence contributions of bound and unbound nadh and fad from the protein background and quantify the spatial distribution of each species with unprecedented spatiotemporal resolution the developed methodologies will be validated by monitoring cellular metabolism in human primary cells and tumour cell lines this study will solidify our understanding of nadh and fad autofluorescence in complex cellular environments and substantially expand the analytical toolset by which quantitative information about metabolic dysregulation can be obtained thereby advancing mpmflim as a research and diagnostic tool for metabolic diseases
mobilising and professionalizing transnationally the health ncp community skills and services

the objective of hnn30 is to facilitate the transnational cooperation between national contact points ncps for the cl1 in order to achieve a consistent and harmonized level of ncp support action will last 7 years to bridge ncps to next programme next to developing support for the facilitation of daily challenges for all ncps we put the focus on lowering the entry barriers for new ncps and offer particular support services for widening country ncps and applicantsthe role of the ncp has become progressively more visible and consistent alongside the 7th and 8th framework programmes moreover since more than a decade the ec is providing funding to develop joint actions that helps ncps getting organized in international networks thus contributing to best achieve its ri and outreach objectives ncps are again an essential component for the brand new programme horizon europes implementation they can be envisaged as the ambassadors of the worlds greatest collaborative research programme in the member states ms associated countries ac and third countries tc by spreading awareness giving specialist advice and providing ontheground guidance they must ensure that the new programme becomes known and readily accessible to all potential applicants irrespective of sector or discipline hnn30 health ncp net has been made to give continuity to the previous network set up under h2020 and to maintain its identity and recognizability within both the ncp community and the wider applicants community and because cl1 is sometimes referred to only as health for shortening and simplification reasons four major target groups are addressed in the 7 years project activities i appointed cl1 ncps ii their clientsapplicants iii other ncps and important stakeholders and iv the european commissionhadea
transforming bone cancer therapy with composite biomaterials encapsulating plasmagenerated rons

improving the survival of patients with osteosarcoma has long proved challenging osteosarcoma is a rare bone cancer less than 02 of all cancers however it affects mainly children and young adolescents the standard therapy for osteosarcoma consists in the surgeon removing the entire tumor with negative margins resection of larger areas of bone than the tumor itself to ensure that no cancer cells are found at the edge of the tissue removed this means that in some cases these surgeries associate limb amputation and even when it is not the case most patients that undergo limbsparing surgery need reconstructive surgery to regain limb function the aim of transformer is to bring closer to the market a solution that will allow to simultaneously treat bone cancer in absence of side effects while allowing bone regeneration the product to be developed in transformer puts together for the first time bone regeneration biomaterials with an innovative therapy for cancer that in contrast to chemotherapy up to now has shown no secondary effects cold atmospheric plasmatreated hydrogels the technology is protected by two pct transformer value proposition the product focused in in transformer will have a double advantage for the patients and clinicians it will be a local therapy that will allow simultaneous bone cancer treatment and bone regeneration transformer is structured along several objectives i to preclinically validate the plasmatreated biocomposite as a potential therapy against bone cancer and towards bone regeneration advancing the technology from trl of 3 to 5 subsequently making it ready for clinical development and transfer to a spinoff or a third party company ii to consolidate our ip position iii to adapt the development roadmap to the regulatory requirements iv to build a comprehensive business case for the exploitation of the technology and subsequent strategy for knowledge transfer
strategic energy technologies plan annual 2023 conference in barcelona spain

fecyt as a foundation in charge of supporting the ministry of science of spain presents a proposal to host the set plan conference 2023 in barcelona spain during the spanish presidency of the eu the conference will take place in barcelona on 13 14 november 2023 the agenda includes 3 highlevel panels dedicated to technological sovereignty energy system resilience and the european solar strategy where we expect the attendance of commissioners simson and gabriel in addition to this 4 thematic sessions dedicated to energy storage energy efficiency offshore technologies and biofuels will take place as well as interactive sessions for crosscutting issuesthe event will count with the attendance of the spanish minister of science and innovation the minister of industry trade and tourism and the spanish minister for ecological transition the first day will be closed by a formal dinner the conference will promote energy research and innovation across the eu and enable discussions among different public and private stakeholders the results will include among others recommendations for the set plan implementation working groups and for the future of the eu research and innovation programmes
new european bauhaus stavanger

in nebstar 16 partners will join forces to make the transition to climateneutral cities inclusive beautiful and sustainable for by and with all stakeholders stavanger as the firstgeneration neb lighthouse will provide experimentation demonstration insight and guidance on neb principles in urban transitions in cooperation with twinning cities prague and utrecht and peers in europe and the nordics the project will demonstrate how territorial transformation plans can be operationalised with neb principles to accelerate the journey towards climate neutrality in nebstar neb principles will be used to address four emblematic challenges 1 cocreating a new sense of aesthetics for climateneutral cities and communities that captures places unique qualities history and potential and generates a sense of belonging pride and ownership 2 reconnecting with nature to boost resilience and a sense of community giving new life to the spaces in between buildings through food and nature 3 creating temporary meeting spaces in urban transition areas that embrace diversity and strengthen the identity and uniqueness of people and places that need it most 4 cocreating cobenefits for the neighbourhood and city through multifunctional use of spaces and infrastructures the project will deliver a detailed roadmap for fullscale implementation of stavangers territorial transformation plan supported by an extensive cocreation process a portfolio of policy strategies and tools financial and partnership models the plans will be cocreated with local stakeholders and partners tested in demonstrators in the three cities jointly evaluated with stakeholders and experts and exploited and replicated in cooperation with nordic and european neb and missions communities the nebstar impact model will capture the social cultural financial governance and technical impact on the built environment and the stakeholders that affect are affected by them
harnessing ai and dataintensive technologies

the objective of harness is to train a multidisciplinary cohort of 13 phd students in an international doctoral network specialising in ethics law and technology the network will offer comprehensive training supervision and secondments allowing individuals to become experts in their specific disciplines while gaining practical knowledge across various fields the program is supported by an excellent team of partners who are world leaders in their respective domains the ethical and sociotechnical impacts of the current and forthcoming ai and dataintensive information systems eg common european data spaces require careful multidisciplinary consideration and foresight techniques regarding their alignment with eus values sovereignty and economic and societal goals the new european regulations on data and ai should be supported by robust methods and tools to empower citizens and civil society to swiftly comprehend navigate and address emerging threats to fundamental rights harness will analyse the joint impact of new ai and dataintensive technologies and their regulation considering legal entanglements new legal compliance tools and the consequences that can be anticipated from ethical societal and economic perspectives ai and data legislation will be formalised and operationalised under the law as code paradigm using international standards and semantic web technologies specific cases such as ai foundational models impact of new regulations on competitiveness and the interplay of selfsovereign identity in common european data spaces will be analysed in detail harness will utilise and build upon the state of the art in open information systems and knowledge engineering to develop appropriate methodologies tools and taxonomies to assist with regulatory compliance deliberation and agreement on ethical norms this will involve charting the constellation of possible systems anticipating new risks and developing effective mitigations
social cohesion and subjective wellbeing an exploration of their dynamic interplay amongst migrants in vienna and budapest

wellcoh seeks to explore the relationship between social cohesion sc and subjective wellbeing swb in the case of immigrants in vienna and budapest its innovative approach is not simply the strong linkage of the two concepts but rather the attempt to understand their twoway causal relationship within one research frameworkthe aim of the project is to answer the following questions how do immigrant communities perceive social cohesion social exclusion perceived tensions intergroup trust etc and subjective wellbeing life satisfaction happiness eudaimonia in comparison with the nativeborn population and the european statistics has immigrants wellbeing improved linearly with their material gains or has it failed to reach the expected level due to the immaterial factors what role do social relationships play in this process and how does swb influence their migration intentions stay permanently return to the country of origin or leave for another country how do the groupspecific swb differences influence the strength of social cohesion in vienna and budapest and what are the main differences between the two cities regarding the social cohesionsubjective wellbeing nexusthe project applies a mixed methods approach including secondary analyses literature review statistical data international and national surveys eqls eusilc vqls and the hungarian microcensus and the combination of qualitative and quantitative methods focus groups interviews and two additional surveys in vienna and budapest the empirical findings will contribute to improving the existing theoretical literature and they are expected to facilitate more effective evidencebased policies in both countries the challenge of urban futures research platform at the university of vienna will host the project under the supervision of prof yuri kazepov an internationally renowned expert in urban sociology