Dragon09/odtu_chatbot huggingface dataset:
spying on ultrafast structural changes through three sets of eyes

modern ultrafast laser technologies have initiated a femtosecond revolution revolution in chemical physics allowing the motion of nuclei within molecules to be visualised on the femtosecond millionth of a billionth of a second timescale the insights from femtochemistry experiments allow detailed probing of the mechanics underpinning chemical reactions and are therefore invaluable for fundamental investigations into molecular structure and reactivity this proposal aims to advance understanding of how carbonyls a key class of organic molecules found within the earths atmosphere with important implications for understanding radiative forcing and climate change react upon excitation by ultraviolet light using stateoftheart ultrafast experimental techniques whilst this crucial photochemistry has been studied by other techniques previously a deep understanding of the complex electronic and nuclear dynamics which control the outcomes of the possible photoreactions is so far elusive throughout the grant three different experimental techniques ultrafast electron diffraction ultrafast xray diffraction and coulomb explosion imaging each offering complementary structural information will be exploited to gain an exquisitely detailed view of this important fundamental photochemistry by studying a series of related carbonyl molecules insights will be gained into the broad class of carbonyl molecules as a whole furthermore the results will also assess the relative applicability of these experimental techniques which have only been facilitated by recent technological advancements in the field of freeelectron laser science to probing complex molecular photochemistry on the shortest timescales consequently the results will be of widereaching impact both in the fields of atmospheric science and within the evergrowing multidisciplinary community which utilizes modern freeelectron lasers to record socalled molecular movies
combination therapy for the treatment of metastatic melanoma using magnetic nanoparticles

metastatic melanoma is a hardtotreat disease and it remains as one of the most worrisome cancer there is an urgent need to improve the current therapies chemotherapy radiotherapy that have a limited efficacy a single therapy is not efficient to tackle metastatic melanoma and a combination of therapies is thus emerging as a necessity to efficiently eradicate all cancer cells recently the development of immunotherapies has shown promises in particular chimeric antigen receptor cart cells nevertheless the physical barriers represented by cellular and noncellular components of the tumor microenvironment combined to the abnormal tumor vasculature and high interstitial fluid pressure hamper an efficient tumour infiltration of cart cells in this context thanks to a network of 18 partners including 10 nonacademic partners melomanes aims to train doctoral researchers for the development of a combined therapy exploiting the properties of magnetic nanoparticles to induce damage on the tumor microenvironment by magnetic and optic hyperthermia in order to facilitate the infiltration of cart cells this therapeutic approach combining hyperthermia and immunotherapy is versatile as it could be also applied to other types of solid tumors research and transferable training of the doctoral researchers will be performed in a highly interdisciplinary intersectoral and international environment in addition to acquiring skills related to the research project they will be trained also in open science communication and dissemination responsible research and innovation circular economy ethics data management entrepreneurship marketing intellectual property and gender dimension in research their competences will be validated through certification and qualification examination allowing a new generation of highly skilled doctoral researchers to emerge with a highlevel training in particular in the multidisciplinary field of nanomedicine
chaperone action a thermodynamic view

the goal of the proposed study is to obtain a fundamental understanding of the molecular mechanism and thermodynamics of chaperone action chaperones are critical components of all organisms and serve to ensure a healthy state of the proteome the proposal concerns a class of chaperones that increases the solubility of client proteins the activity of these chaperones exhibits a number of crucial but poorly understood features for instance there is a remarkable specificity in action combined with promiscuous recognition across sequence space these features are challenging to achieve through molecular design and raise the question of the general physical principles which govern chaperone activity our research aims to reach a general understanding beyond specific effects and we will study nine binary combinations of three chaperones and three client proteins our strategy is to first characterize in detail the aqueous solubility and selfassembly of each chaperone alone including the phase behaviour with this knowledge and our existing deep understanding of client selfassembly we turn to chaperone action to study the thermodynamics of chaperoneclient mixtures to determine the phase behaviour structure of chaperoneclient coassemblies the mixing stoichiometry and quantitative equilibrium parameters we use stateofthe art scattering spectroscopy and microscopy methods and develop new methodologycommon to the field is a mechanical view and search for specific sites in chaperone and client proteins that mediate their mutual interaction but the promiscuity makes us question whether such sites exist we take a new approach not pursued by others in the field in that we search for general molecular and thermodynamic principles of chaperone action our results may guide the design of small molecules that operate according to the same principles which can serve as therapeutics toward some of the most devastating diseases affecting humans
resilient manufacturing lines based on smart handling systems

manual and automated production lines must evolve to produce more and diverse with less however they need to address shortcomings such as high product variants requiring tool level dexterity and resource level reconfigurability lack of cognitive perception systems to allow autonomous reasoning and operation absence of adaptable control to accurately handle a variety of workpieces and materials and inefficiency of planning systems in addressing holistically all hierarchical production levelssmarthandle will research technologies to address these needs and support european industry by implementing a intelligent reconfigurable agents to provide dexterity in a range of handling applications b ai based reasoning enablers to optimize the flexibility potential of these agents and c higherlevel planning and coordination mechanism to allow the successful and scalable deployment of such solutions in real life use casessmarthandle is a research and innovation action ria nevertheless it acknowledges that such technologies can be meaningful only if they lead to solutions that address real life needs thus it has engaged 3 use cases from the consumer goods meniconhandling of deformable delicate and high precision parts contact lenses metal industries alumil packaging of large variable section materials aluminum profiles and automotive tier1 suppliers abee disassembly of complex products batteries involving dexterous operations that are not possible to implement with the existing technologiesssh aspects will be addressed demonstrating benefits for workers by reducing their involvement in unsafe and unhealthy tasks improving their working conditions when working in areas where the smarthandle reconfigurable solutions will operate
towards an evidencebased model for big data policing evaluating the statisticalmethodological criminological and legal and ethical conditions

big data policing is an innovative strategy that uses historical data to forecast when and where there is a high risk of new crime events in order to use police resources more efficiently and proactively and ultimately reduce crime rates big data policing models can consist of variables based on crime data available in police databases eg previous crime events socioeconomic data eg poverty index residential mobility opportunity characteristics eg the presence of shops distance to nearest highway data from new technologies eg intelligent cameras and other known predictors of crime eg police patrol intensityhowever there are several research gaps that need to be addressed first knowledge about and expertise in big data policing in europe is currently fragmented second there is a lack of interdisciplinarity with regard to big data policing studies and yet the involvement of several disciplines is required when studying the issue third there is a lack of scientific evaluations of big data policing modelsthe overarching objective of this erc project is to unite and integrate the statisticalmethodological criminological legal and ethical dimensions of big data policing in an evidencebased model that will be tested by different randomized controlled trials and built on the principles of an international ie european and interdisciplinary approach the latter aim should be enabled by incorporating and conducting different phd tracks focusing on these specific dimensions which should allow better knowledge insights and understanding of big data policing to be developed this approach is innovative and radically different from the existing commercial and economic initiatives which lack transparency on their predictive reliability and validity effectiveness and legal and ethical safeguards
agroecological crop protection towards international coinnovation dynamics and evidence of sustainability

acropics addresses the need for sustainable agricultural practices that use little to no harmful crop protection inputsacropics 1 reinforces 12 placebased coinnovation initiatives involving local actors implementing agroecological crop protection acp 2 connects these initiatives to each other and to research innovation teams worldwide 3 produces scientific evidence of the sustainability of acp systems 4 supports these initiatives via international research and innovation actions 5 highlights these initiatives at the international level and 6 contributes to creating and training an intersectoral network of teams and future experts promoting acp acropics associates 15 organisations 12 academic 3 nonacademic with biological ecological and social science expertise it plans staff exchanges among academia biocontrol industries and 12 sustainable agriculture systems sas in 10 countries collaborative activities will 1 codesign and implement innovation strategies coupling ecological technical and organisationalinstitutional innovations in an innovation pushpull approach 2 produce knowledge enabling acp innovations certification schemes ecological infrastructures etc and 3 produce sustainability assessments and communicate them to a wide range of stakeholders from growers to policymakers and investors expected results and impacts are the creation of a core team of an emerging largescale international initiative on acp drastic increases of sustainability in 12 systems covering main crop types and further impact on 100 similar systems worldwide via dissemination in connected networks stateofthe art research results promoting acp training of future researchers with hybrid expertise adapted to the challenges faced by acp engagement of a large number stakeholders across food value chains demonstration and exploitation of new innovations ranging from certification schemes to biocontrol products and services
unravelling the nitrogen fixationprimary production feedback loop implications for carbon cycling and oceanic health

the project niprofeed delves into the vital interplay between primary producers nitrogen fixation and particle dynamics in aquatic ecosystems primary producers play a crucial role in capturing roughly one third of excess carbon dioxide and converting it into organic particles central to the oceans biological pump this process however contributes to oxygen depletion as sinking particles lead to organic matter respiration and subsequent deoxygenation of bottom waters diazotrophs specialised microbes capable of nitrogen fixation provide a significant portion of nitrogen input into oceans supporting primary production niprofeed introduces the hypothesis that diazotrophs supplying nitrogen to primary producers can amplify particle formation initiating a positive feedback loop that impacts carbon export and oxygen levels to explore this feedback loop niprofeed will employ cuttingedge techniques including highthroughput sequencing singlecell rate measurements and biogeochemical modelling this will unravel the composition and functional role of freeliving and particlebound diazotrophs shedding light on their contribution to nitrogencarbon fixation by implementing these parameters into an integrated model the intricate relationship between nitrogen fixation and primary productivity will be investigated addressing this hypothesis niprofeed aspires not only contribute significantly to scientific advancements in the field of marine science but also aligns with eu sustainability goals by shedding light on climate change impacts on our ocean
solar energy to power co2 reduction towards c2 chemicals for energy storage

sorec2 aims at developing a breakthrough technology for a direct transformation of sunlight and co2 into chemicals such as ethanol or ethylene for a safe energy storage sorec2 brings expertise in photonic structure design for optimal sunlight harvesting together with expertise in catalysis to reduce co2 into products that can store chemical energy or with a high economical interest on the light harvesting side icfo will develop a system composed of three complementary lightabsorbing elements in order to obtain the largest possible broadband sunlight harvesting this system will rely on newly developed light trapping nanoconfigurations and will enable fine tuning of the potential energy needed for the reduction reactions via an innovative arrangement of the low middle and high bandgap materials caltech will develop a hybrid catalyst system exploiting a novel combination of co2 reduction catalysts with a redoxproton mediator to lower overpotentials and enhance selectivity towards c2 products such as ethanol or ethylene for the photoanode where the chemistry and the optics in a photoelectrochemical cell pec are interwoven uab and icfo will design a multilayer configuration to achieve an optimal electrochemistry while not undermining the optical performance of such pec to ensure a transformation of the scientific research into a technology breakthrough with substantial economical and societal impacts sorec2 incorporates unife to define the pec upscaling roadmap and the companies gem saule and vitsolc for the creation of new markets finally to identify nontechnical barriers such as political economic and societal that sorec2 may encounter and to engage relevant stakeholders and citizens on the route towards market uptake sorec2 incorporates dbt a nonprofit organization whose mission is to ensure that technology development is shaped and informed by cooperation between citizens experts stakeholders and decisionmakers
assessing efficacy and safety of genome editing approaches for sickle cell disease

sickle cell disease scd is one of the most prevalent monogenic diseases in europe a single amino acid substitution in the betaglobin chain of the adult hemoglobin hb drives red blood cell sickling and multiorgan damage the clinical severity of scd is alleviated by the coinheritance of mutations causing expression of fetal gammaglobin in adult life a condition termed hereditary persistence of fetal hemoglobin hpfh transplantation of autologous genetically modified hematopoietic stemprogenitor cells hspcs is an attractive therapeutic option for scd patients to this end genome editing approaches based on the use of sitespecific nucleases or more recently base editors have been explored by many groups including teams in our consortium these approaches either correct the single point mutation causing scd or reactivate fetal gammaglobin expression by mimicking hpfh mutations on the other hand preclinical data from scd patients or scd mouse models as well as preliminary data from our labs suggest that scd hspcs are characterized by a high mutational burden oxidative stress and expression of inflammatory genes this can alter hspc properties as well as their interactions within the bone marrow niche in the context of gene therapy it is essential to understand the mechanisms underlying scd hspc dysfunction and assess the impact of genome editing approaches on scd hspcs in this proposal we have assembled a multidisciplinary team to i understand the molecular and cellular mechanisms underlying scd hspc autonomous and noncellautonomous dysfunctions and ii evaluate the impact of established and novel genome editing approaches on scd hspc properties and genome integrity this study will lay the foundation of an improved gene therapy strategy to treat scd and provide best practice tools and protocols for genome editingbased therapies in hspcs
sensorita data driven waste management

sensorita is developing a cuttingedge radar sensor system to help waste companies better monitor their container fleet we are combining our hardware sensor specially designed to endure extreme environments with our machine learning based software platform to analyze and predict how our customers can automate and streamline waste management and cut costs and emissions we are targeting construction waste the largest source to waste in europe and large open waste containerssensorita spins out of the sensor and data science community at the norwegian university of life sciences and the technology is based on research of the masters thesis of the female founder and ceo ulrikke lienthe objectives of this proposal is to strengthen the commercial and organizational aspects of sensorita the activities in the work plan are related to activities within sales organization building and business development sensoritas funding so far is linked to the grant from innovation norway which covers our technical development however succeeding as a deep tech company is a lot more than the technological development
detox satdrive propulsion

satdrive is based on an entirely new paradigm use of safe abundantly available propellants and simplified direct ignition system increasing throttability compared to other technologies satdrive module is the key enabler for esas science missions to benefit society it also supports adoption of civil space systems such as worldwide internet connectivity bridging the digital divide and earth observation for monitoring climate change and methane emissionssatdrive is simplifying operations through its bipropellant thruster for small satellites between 100500 kg this proposal is centred on the developments needed to bring this product to marketdawns safe reliable and affordable propulsion technology was first developed for the nanosatellite industry an industry that is rapidly growing adverse to use hydrazine quickly gaining international traction we are expanding this technology to the midsized satellite market with a larger thruster and supporting system
decarbonising energyintensive industries with renewable synthetic fuels

the future energy mix will include a variety of fuels efuels allow to store the excess renewable energy into high energydensity chemical compounds representing the ideal candidates for energy transition in energy intensive industries eiisthe desire network will train the next generation of specialists in exploring the use of efuels in existing combustion devices to better guide the energy transition and to help the decarbonization of eiis in europe the academic and industrial partners of desire will work synergistically to generate a cohort of 15 welltrained young scientists with interdisciplinary skills in combustion science mechanical and chemical engineering computer science and modelling that will be ready to propel and advance future engines towards pollution control fuelflexibility and higher efficiencies such a broad spectrum of training is currently lacking due to the fragmentation of the emerging field of sustainable combustion across europe perhaps more importantly the need nature and magnitude of these new skills is only now emerging the desire network will equip its doctoral candidates with a unique combination of skills essential to become future research leaders or entrepreneurs in the sustainableenergy sector they will drive this research field forward and accelerate the energy transitionthe main scientific goal of desire is to develop predictive tools including mathematicalnumerical models and experimental measurement techniques able to describe the combustion of efuels that can then assist engineers in designing new technologies andor modifyingadapting existing combustion equipment and technologies to be suitable to use these powerful fuelsthe program is heavily supported by keycompanies in the transport sector rollsroyce safran fuel and chemicals production distribution air liquide and electricalmechanical power technology condevo engie mitis
ship clones characterization and search for biomarker of marine transmissible cancers

ship clones characterization and search for biomarker of marine transmissible cancers clonally transmissible cancers are cell clones that are transmitted between individuals via the transfer of living cancer cells there are only three known types of naturally occurring clonally transmissible cancers one of which is a disseminated neoplasia dn found in marine bivalves dn is a leukemialike cancer characterized by the proliferation of hypertrophied cells in later stages of the disease these cells spread throughout all tissues destroying their normal architecture and causing the death of their host organism a polyphyletic origin of the dn has been detected in the common cockle cerastoderma edule dn has appeared on at least six different occasions and the six clones currently known coexist in cockle populations of the european atlantic coast in the present proposal high resolution lipidomics and proteomics will be used to screen for clonal biomarkers of dn and help to better understand the biological systems of transmissible cancers marine transmissible cancers are interesting biological models to better understand cancer transmissibility and metastasis marine clones likely ship using ocean currents to colonize new hosts in different regions it is likely that they may also be unintentionally introduced by the action of man in diseasefree regions hence these cancers represent a potential threat for marine ecosystems as they negatively impact keystone species bivalves that also have important socioeconomic value for fisheries as such it is paramount to successfully identify monitor and characterize the prevalence of clonal dn in marine bivalves before any successful prevention and mitigation actions can be applied