Dragon09/odtu_chatbot huggingface dataset:
novel human chaperone mechanisms counteracting protein misfolding and aggregation in the cell

molecumolecular chaperones are vital for maintaining proteostasis by protecting our cells from the deleterious effects of protein misfolding and aggregation the diverse 50chaperone jdomain protein jdp hsp40 family acts as cells first line of defense binding and remodeling nonnatively folded proteins and facilitating their transfer to downstream chaperones recent discoveries from our lab have shown that jdp function is far more complex than previously described identifying both a novel mode of regulation by which dnajb1 coordinates amyloid disaggregation and a new mechanism by which class a jdps recognize destabilized proteins based on these findings and the sheer diversity of human jdps we propose that these chaperones employ many additional yettobediscovered mechanisms to carry out their vital cellular roles obtaining a structural and functional understanding of these chaperones is further crucial as mutations in jdps have been linked to many pathologies including myopathies neurodegenerative diseases and metabolic disorders here we aim to uncover these novel jdp functional mechanisms determine their role in addressing diverse proteomic challenges and characterize how their malfunction leads to disease study of jdps has proven challenging due to the dynamic nature of these chaperones their transient interactions with clients and the instability of misfolded proteins the advanced methyltrosy nmr techniques used in my lab are however ideally suited for such large and dynamic systems furthermore we have developed new nmr and biophysical assays allowing the monitoring of chaperone interactions with misfolded and aggregationprone substrates in real timeusing these approaches this project will unveil the structures and functional mechanisms of the diverse human jdps introducing fundamental new concepts into the chaperone field and paving the way for therapeutic strategies targeting protein misfolding and aggregation diseases
naturescapes naturebased solutions for climate resilient nature positive and socially just communities in diverse landscapes

naturescapes addresses the pressing challenge of realising the transformative potential of naturebased solutions nbs for climate change biodiversity loss and social justice despite progress in the field our knowledge of the synergies and tradeoffs from implementing nbs at scale across diverse and interconnected landscapes is limited at the same time there remain challenges in designing the governance arrangements finance and forms of citizen engagement are needed while the value nbs for diverse social actors is increasingly contested especially where they seem to bring benefits to some and new forms of inequity and exclusion to others advancing the transformative potential of nbs requires that we address these underlying challenges together ensuring they are both effective and just naturescapes will advance our understanding of how nbs across interconnected urban rural and coastal landscapes generate benefits for diverse communities particularly in areas of socioeconomic disadvantage inequity and risk we will analyse the synergiestradeoffs emerging for climate biodiversity and communities in 30 naturescapes across europe latin america and the caribbean lac and the usa including 12 indepth casestudies focusing on the dynamics of implementation creating new insights and tools in 7 of these cases we will codesign interventions with local collaborators that test transformative theories and practices of change and identify how these can be replicated led by utrecht university the naturescapes consortium brings together expertise across the sciences social sciences and humanities from five european universities the nature conservancy wwf and grupo laera a leading consultancy in nbs and ecosystem services in lac and an international collaboratory of stakeholders together we will adopt a transdisciplinary approach to take forward the realisation of nbs that are transformative for climate change biodiversity and communities
architecture colonialism and labour the role and legacy of mass labour in the design planning and construction of public works in former african territories under portuguese colonial rule

the discipline of architecture when dealing with public works associated with colonialism and territorial occupation still focuses on the analysis of the constitution of the design teams of the colonial public works offices of the architects and engineers themselves this focus on the designing elite misses a critical input to these public works namely the labour force responsible for realising these structures as such critical questions about the labour force engaged in the spatialization of architectural plans are still missing who were those workers what ethnic groups did they come from how did they emerge in contingents that could aggregate a few thousand individuals what was their recruitment like what expectations did they have how were they paid what training did they receive what repercussions did these mostly compulsive work experiences have what conflicts did they provoke in colonial societies how did they resist recruitment how did they collaborate how to deal with this legacy in answer archlabour will develop a new theoretical framework for assessing mass labour in order to shine a spotlight on these invisible workers thus establishing a connection between historical subalternity and the inequality that still haunts communities inheriting this past through the study of the diverse colonial experiences of the african countries that have portuguese as one of their official languages cape verde guineabissau so tom and principe angola and mozambique and covering a wide period from the modern colonization that begins after the berlin conference through the industrial capitalisms exploitation praxis up to the years immediately following african independence the project will cross the history of colonial architecture and the subject of labour with the history of science applied to construction and postcolonial studies in architecture
infant feeding decisions in two cultural locations

the aim of the project is to critically examine the factors influencing mothers decisions on infant feeding in two different cultural locations ireland and finland and to provide innovative research on womens experiences of breastfeeding and bottlefeeding the project highlights that infant feeding decisions are not made independent of social and cultural context there are two specific objectives 1 to explore and identify the cultural expectations and policies concerning infant feeding in ireland and finland this objective is the groundwork for ro2 and informants are people working and volunteering in breastfeeding associations and midwife organizations 2 to research infant feeding as a contextual practice that has personal cultural and social levels this is achieved by analysing the interview narratives conducted with mothers from both countries while being sensitive to intersectional differences and socially constructed subject positions the research method is qualitative and has an interdisciplinary approach combining content analysis and narrative analysis methods with gender studies media studies and sociology an intersectional reading is used while analysing the data the project contributes to the research of infant feeding and breastfeeding which is set as a health priority throughout europe the reasons behind breastfeeding or bottle feeding are various and this research adds knowledge and understanding to the different levels of infant feeding the breastfeeding rates in selected countries are very different in finland over 95 of mothers initiate breastfeeding while in ireland the rates are much lower and little more than 60 are breastfed this makes irelands breastfeeding rates one of the lowest in the eu still both countries are affected by the savings targeted to maternity services the lack of support in the early days of mothering the pressures of profit gaining formula industry and the constant sexualisation of breasts
aienabled data lifecycles optimization and data spaces integration for increased efficiency and interoperability

pliades advances the soa dataspaces reference architectures towards a step change on the use of data as key enabler of technological advances in ai and robotics to this end pliades researches into novel aienabled tools to advance full data life cycles integration both within and between data spaces sustainable data creation methods through data compression filtering and normalization will be developed to allow efficient and greener storage in a dataoriented future data privacy and sovereignty will be further ensured through standards and decentralized protocols to protect dataproducing organizations and citizens alongside data sharing will be revolutionized through novel aibased brokers and connectors using extended metadata shaped through the projects best practices and domain experts knowledge on top of these active data discovery services through cross domain ai connectors will allow creating linked data spaces enabling interoperability between previously disconnected entities while data quality assessment services will facilitate real time data evaluation extended synergies with eu initiatives will be established in order to contribute models strategies and technologies for a common european data space our outcomes will be evaluated in six use cases focusing on direct advancements in key ai and robotics technologies for everyday use oriented around multiple data spaces mobility healthcare industrial energy and green deal our use cases provide a challenging validation suite involving vast heterogeneous data creation management and sharing while addressing full data lifecycles in multiple major domains through the developed ecosystem ccam and adasad car technologies will be enhanced hri for robot operators and healthcare patients will be reshaped while further advanced integrated data spaces will be deployed in the healthcare manufacturing and green deal sectors aiming to reduce carbon footprints and shape a greener future
open innovation platform for optimising production systems by combining product development virtual engineering workflows and production data

nowadays european manufacturing enterprises are facing a number of challenges in a turbulent globalized market facing unprecedented and abrupt changes in market demands an everincreasing number of product variants and smaller lot sizes intensifying the worldwide competition and causing a continuous pressure on production costs product quality and production efficiency therefore novel product development strategies for ensuring and optimising the manufacturing of new products or variants in lowvolume production systems must be implemented pioneer aims the development of an open innovation platform and interoperable digital pipeline for addressing a designbysimulation optimisation framework for that pioneer implements inline feedforward control strategies for enhancing the efficiency of the industrial systems in highmixlowvolume production schemes based on the connection between materials modelling and materials characterisation simulationbased digital twins and datadriven models updated through distributed production data from embedded iot edge devices and product qualitypioneer is built over five pillars for development a common methodology deployed in two demonstrators by involving multidisciplinary optimisation for ensuring certified path planning strategies for the manufacturing of topology optimised structural elements through wirearc additive manufacturing waam in construction ie lowvolume production schemes as well as for ensuring an efficient design and manufacturing strategy for the manufacturing of carbon fibre sheet moulding compound cfsmc components in automotive ie highmix production schemespioneer is built on the knowledge and results gained in i previous h2020 eu projects ii associations ie emmc asbl iof vmap standard community idta and iii commercial products from project partners
consolidating plans for the atacama large aperture submillimeter telescope

the landscape of future groundbased european astronomical research infrastructures expected to start in the 2030s is broad and diverse ranging from lowfrequency radio skao to the optical elt est all the way to cosmic rays ctao and gravitational waves einstein telescope there are two glaring omissions however the first is a sensitive high resolution nextgeneration facility operating at submillimeter wavelengths 03510 mm a crucial observing window for the study of a broad range of astrophysical objects from our solar system to the milky way nearby galaxies and the distant universe the second is that currently planned facilities are not truly prepared to operate in a low carbon emissions future meeting the needs of the research community and the aspirations of the eu for carbonneutrality this project consolidating the plans for the 50meter atacama large aperture submillimeter telescope atlast directly addresses both needs providing solutions that will inform other observatories along the way especially our partners esfri landmark esoelt and project est our ambition is to harness european knowhow and cooperate on a global scale to revolutionise our understanding of the submm universe while pushing observational astronomy towards a greener future strengthened by a h2020funded design study and an engaged community of about 200 researchers worldwide we have produced science cases telescope conceptual designs and plans for a sustainable offgrid power system we are now ready to consolidate the atlast concept prototype and test our technology solutions perform a full lifecycle assessment of the facility and to expand our user community by the end of this project atlast will have increased the technology readiness level of its crucial components and undergone preliminary design review ready to move the project to its implementation phase
mystical emotions and the limits of language in contemporary italian french and english literatures

this project will contribute to an emerging research field dealing with mysticism in contemporary literature and represents the first attempt to study contemporary mystical literature from both an interdisciplinary and comparative standpoint the framework addresses the connections between mystical emotions and language pushing the boundaries between literary analysis the philosophy of emotions and the philosophy of language unlike many contemporary studies in literature and religionthat mix or interchange concepts such as mysticism sacred epiphany etcthis project advocates for an accurate definition of mysticism from both a historical and a philosophical perspectivethe overall objective of this project is to map and examine the phenomenon of mystical experience through a multilingual and contemporary literary corpus that transcends the limitations related to the timespan and the religious context of even the most important academic research in this field the key outcome of this theoretical and literary inquiry will consist of a classification of mystical emotions in contemporary literature in different languages english french and italian including a description of the main features and attributes of mystical emotions and experiences the research outputs will be crucial additions to the current stateoftheart and will represent an essential contribution to enhance interreligious dialogue as well as map spiritual imaginaries in contemporary european culture
mindguide improving the mental health of adolescents with digitized screening process and feedback loop optimisation

there is a significant societal challenge of high levels of mental illness in adolescents aged 1320 as many as 70 of young people with mental health conditions do not receive adequate professional help negative stigmas associated with being mentally ill overburdened healthcare systems with long waiting times and a traditional approach that is largely undigitized are some of the largest barriers to adolescents accessing help zamax founder and ceo dr lina klanek is a specialist in adolescent psychiatry she is acutely aware of the obstacles that prevent young people from accessing mental health support and is using her knowledge in the field to develop mindguide mindguide is a unique interactive platform for youth mental health we are developing a chatbot to detect likely mental health conditions in the user based on these results mindguide will offer a clinical treatment suggestion providing connections to access these following the treatment process mindguide will conduct a followup with the user within this it discovers whether the suggested treatments were engaged with if they were successful and if not why the data collected in this stage will create a feedback loop to inform and optimise the entire platform particularly the screening process and the treatments suggested leveraging the proposed bes support the objectives of the project include developing and incorporating feedback loop further understanding and developing the market opportunity in the context of latest conditions and drivers and alongside final technical solution development refining a detailed and rigorously reviewed business plan clearly defining the product offer and most effective routes for dissemination to target markets establishing clear plans for scaling the business opportunity and operations
optimized upscaled technology for nextgeneration solid oxide electrolysis

the main aim of outfox is to remove scale as limiting factor in the deployment of soel technologies while proving their potential to become the preferred option for green hydrogen production by combining experimental results up to 80 kw scales with identification of optimal cell and system designs outfox will prepare soel for industrial scale systems of 100 mw with an lcoh as low as 27kg hydrogen and applicability to mass manufacturing linesthe industriallydriven outfox consortium will combine expertise on cell stack and module development manufacturing and full system evaluation to advance the maturity of soel and contribute to the targets of the clean hydrogen ju sria outfox will achieve current densities of at least 085 acm2 through the use of cells with 25 less thickness than current high volume stateoftheart improving sustainability through reducing total materials requirements scaleup will be approached from two sides 1 development and validation of cells with geometric areas up to 800 cm2 that are compatible with atscale manufacturing techniques and 2 validation of optimized design concepts with increased numbers of stacks per module the partners will validate high current density operation with reference scale 144 cm2 industrial scale 300 cm2 and nextgeneration cells 900 cm2 in single repeating units short stacks of 15 cells and 80 kw prototype systems leading to more than 10000 hours of soel operation two separate 80 kw testing campaigns with two different stack configurations and a total of more than 4000 operating hours to be tested onsite at the shell facilities in amsterdam will go beyond the scope of the call text to provide a comprehensive validation of the outfox technology thus providing key data for design of a full scale 100 mw soel system including the module configuration and all balance of plant requirements and preparing the technology for a multimw demonstration following the project end
eu advisory networks to reduce the use and risks of pesticides

the eu farm to fork strategy which is at the heart of the european green deal aims to make food systems fair healthy and environmentally friendly to achieve the objectives of the farm to fork strategy the commission proposed among other new targets to reduce the use and risks of pesticides rurp the main objective of advisorynetpest is to establish and upgrade a network of advisory services across the eu increasing the knowledge sharing between advisors and among the whole akis and the adoption of innovative solutions to rurp by farmers the project will achieve this by 1 developing a eu network of advisors to rurp based on existing networks and national akis covering the 27 eu members states mss and the uk to cover all mss the project will adopt a twinning approach 14 national networks will be created by the project partners and these will engage with 14 associated networks through a twining program the network will cover all european pedoclimatic areas integrating four eu regional clusters and the most relevant crop sectors 2 identifying selecting and shaping novel approaches nas which are technically economically socially and environmentally viable that will be adapted and replicated across the eu 3 exchanging knowledge and training advisors and students to promote the adoption of the nas 4 connecting the project with other national and eu projects initiatives and policy makers 5 scaling up the nas fostering the adoption of innovative solutions by farmers and the whole value chain the project will embrace a multiactor approach gathering 19 partner organisations with a vast experience in advisory and crop protection the consortium will also represent a diversity of akis stakeholders including advisors researchers and other value chain actors as the cornerstone of a regional national and eu level network that will allow a wide sharing of technical and practical expertise to rurp in the longterm
explaining individual lifespan change

the eilisch project will focus on linguistic variation and change in icelandic syntax and it will be the most ambitious attempt so far to model understand and explain individual lifespan change in linguistic behavior drawing on recent advances in sociolinguistics quantitative syntactic theory clinicial linguistics as well as resources recently made available by language technology the project will harness these ingredients and the experience of the pi and the infrastructure present in his language and technology lab in order to facilitate a new kind of a large scale project that will yield substantial progress towards important empirical theoretical and methodological goals as well as benefits for society i will track hundreds of members of parliament via their speeches over their entire political career and interview dozens of current and former mps to establish an even deeper profile of how they use language carrying this research out in iceland is important because of the unusually easy access that researchers have to public figures in this small language community the kind of precise modelling that i describe in this proposal is only possible in a project that builds on substantial preexisting language resources and takes place in a setting where extensive knowledge of the linguistic data and the required technological tools is present my language and technology lab at the university of iceland is the right place to do this and the experience i have gathered in several previous projects will be essential for my teams success however the scale of this enterprise is beyond the means of national funding agencies in iceland thus i turn to the erc so that together we can redefine the state of the art in the study of individual lifespan change