Dragon09/odtu_chatbot huggingface dataset:
understanding the molecular basis of protein folding disorders and protein quality control in muscle

mutations in certain proteins can cause their misfolding and aggregation posing a potential threat to the health of an organism protein aggregation is counteracted by protein quality control pqc mechanisms that reduce the amounts of damaged molecules as we age however the crucial surveillance mechanisms weaken and become less effective leading to protein misfolding diseases the most wellknown protein disorders or proteinopathies alzheimers huntingtons and parkinsons diseases are characterized by the formation of toxic protein aggregates known as amyloids current research focuses on such amyloid diseases however there seem to be many other hidden protein disorders in principle every mutation in a protein can affect its folding and stability and may become pathological only when pqc mechanisms are compromised to better understand this kind of proteinopathy we will generate novel pqc tools and study muscle protein disorders in the nematode caenorhabditis elegans we will design dualcolour fluorescent protein reporters to monitor the misfolding and aggregation of diseaselinked myosin variants our model proteins the myostate library comprising hundreds of mutants with a broad range of folding defects will allow us to study the pathological impact of individual myopathy mutations and investigate cellular rescue mechanisms in c elegans myosin disease mutations cause characteristic defects in motility and muscle structure which can be rescued by dietary restriction this animal model thus provides us with a unique opportunity to perform genomewide screens that will define the pqc network in muscle cells by performing structural and functional analyses of key factors in this network we aim to reveal the fundamental mechanisms of myosin quality control and its regulation our ultimate goal is to understand how the misfolding of functional proteins whether due to mutation or age impairs cell function
fair food and trade systems for africa through food convergence innovation

the fci4africa project champions a holistic approach to african agriculture promoting fair sustainable climateneutral and healthpromoting trading practices while ensuring economic prosperity at all levels and respecting human rights it bridges the gap between technical compliance and social justice by empowering smallholder farmers and small and mediumsized enterprises facilitating trade compliance through a digital platform and enhancing food safety by evaluating the impact of certification criteria like deforestationfree organic and fair trade and guiding policymakers fci4africa fosters a just transition for african farmers processors and traders expanding their intraafrican and eu trading opportunities leveraging past projects and cuttingedge technologies fci4africa connects stakeholders across diverse regions and jurisdictions paving the way for a more sustainable and equitable african agricultural sector
explore the role of nk cells in posttreatment control of hiv1 infection impact of genetic background and early treatment initiation

antiretroviral therapy art blocks hiv replication but cannot eliminate viral reservoirs that originate viral rebound if art is discontinued however the host laboratory originally described some individuals posttreatment controllers ptc capable to durably control viremia after art discontinuation more recently the group has found that hla b35 alleles usually associated with rapid progression in the absence of art are paradoxicaly overrepresented in ptcs and are accompanied with an mhc immunogenetic fingerprint termed bw4ttc2 by the lab related to kireducation of nk cells the proposed work aims to better characterize transcriptional and functional signatures of nk cells in ptc and other people with hiv pwh their evolution since primary infection during art and after art discontinuation and in regard of immunogenetic factors these will be done in three different settings i crossectional analysis in groups of people with wellcharacterized hiv status ii longitudinal samples from the biobank of the primatevisconti study pvisconti iii prospective study of samples from individuals on art since primary hiv infection and carrying b35 bw4ttc2 who will undergo art interruption ati in the context of the anrs rhiviera01 clinical trial overall this proposal should unveil the phenotype and functional activities of nk cell subsets more relevant to posttreatment control the influence of early art initiation and of immunogenetic factors this information may provide important insight for the development of new immunotherapies aiming hiv remission
women in science night celebrate science sustainability and gender diversity

with this project belgian women in science a brusselsbased nonprofit organisation aims to bring women researchers closer to the general public and stimulate the interest in scientific careers among young people with a special focus on gender diversity and inclusiveness citizens of all ages will be able to discover research related to nature space and the 5 eu missions cancer soil deal ocean waters adaptation to climate change climateneutral smart cities allowing them to exchange ideas and experiences with scientists about their careers and breakthroughs to achieve this we will organize over 100 activities engaging the audience like demonstrations focused on climate change and evolution art science exhibitions portraying female scientists workshops focusing on new trends in science and technology such as water and solar power and food of the future the european researchers night night events take place in two inspiring locations in brussels the capital of the european union also enabling the discovery of historic and natural landmarks where research has been conducted for almost two centuries the researchers at schools schools workshops take place in schools with a special focus on reaching vulnerable children in addition some workshops will be organised at a brussels university campus where students can become researchers innovators and in the two musea museum of natural sciences museum and the planetarium of belgium planetarium our awareness campaign will be one of the successful key points in this project a dedicated media plan has been designed and a specialized press office will be involved to promote the activities at national level also promoting our outreach events throughout the whole year on social media channels in order to evaluate the impact we will analyse the target audience reached measure the increase of knowledge and promotion of the researchers figure and understand the level of appreciation
phytoplankton towards valorization of ammoniacontaining liquid for upgraded economy

unicellular small plants microalgae and cyanobacteria have a great potential to valorize wastewater by producing highvalue biomaterials using the contained nutrients however a high concentration of ammonia in wastewater exhibits strong toxicity to microorganisms and prevents the successful cultivation of algae while dilution is the most prevalent solution large consumption of freshwater resources is costly and not sustainable therefore this project aims to develop a novel method to detect algal ammonia inhibition by fluorescence monitoring which will enable direct feeding of undiluted ammoniacontaining wastewaters by controlling the feeding rate in this project appropriate fluorescent methods will be screened first and the screened methods will be applied to algal cells exposed to various types of inhibition a multivariate statistical model will be constructed to distinguish ammonia toxicity from other inhibitions for improvement of feasibility a lowcost fluorescent monitoring device shall be also developed finally the developed methods and devices will be integrated into a longterm ammonia feeding control experiment to evaluate the feasibility during the implementation of the research project the candidate will receive training both from the host institution universidad de valladolid uva and from the centre algatech ca where the external advisor belongs to the candidate will further develop skills in process engineering in the training from uva and learn the mechanisms of fluorescence from ca the expected results of the project include a fluorescent algal toxicity identification tool a lowcost fluorescent monitoring device and the ammonia toxicity control protocol all of which have a strong impact on the field of wastewater treatment aquaculture and algal mass cultivation successful development of proposed methods will enhance the utilization of waste for value creation leading to the establishment of a sustainable society
establishing european production of hydrogen from renewable energy and integration into an industrial environment

ephyra will demonstrate the integration of a firstofitskind renewable hydrogen production facility at industrial scale in southeastern europe by employing an improved electrolysis technology at a scale of 30 mw the largescale electrolysis will be integrated with industrial operations within mohs corinth refinery one of the top refineries in europe and the largest privatelyowned industrial complex in greece it will be operated for at least 2 years under commercial conditions and will supply renewable hydrogen to the refinerys processes and external endusersthe industrially integrated renewable hydrogen production will be developed around a circular economy industrial symbiotic approach as the electrolyser will be coupled with i renewable electricity production ii renewable electricity storage iii an innovative waste heat harvesting technology iv water use environmental optimisation v valorisation of produced oxygen in current moh refinery operations vi a digital twin and vii a dedicated energy management system ephyra will contribute to all electrolysis technology kpis as detailed in clean hydrogen partnership sria objectives therefore the project will demonstrate its reliability for green hydrogen production at the lowest possible cost thus enabling the eu renewable hydrogen economy industry decarbonisation and zeroemission fuels uptakeephyra will be implemented by a strong consortium with robust research innovation and industrial capabilities able to successfully deliver the project within time budget and detail objectives the aim of ephyra is to enhance european synergies on the globally expanding hydrogen market and build a unique value proposition on industrial symbiotic renewable hydrogen production
social industrial collaborative environments integrating ai big data and robotics for smart manufacturing

global economic crises and the covid19 pandemic have dictated manufacturing firms to rethink their production and business models production systems need to adopt both human and automated resources that can work together seamlessly as a response converging aims to develop deploy validate and promote smart and reconfigurable production systems including multiple autonomous agents collaborative robots agvs humans that are able to act in diverse production environments the diversifying factors will be a multilevel ai based cognition line station resource levels which will exploit the collective perception digital pipeline of these resources allowing them to interact with each other and seamlessly coexist with humans under a social industrial environment that ensures trustful safe and inclusive user experiencethe project proposes the development of systems that can1 perceive identify and recognize processesresourcesenvironment and their status by introducing big data real time integration communication architecture digital twins and human in the loop techniques2 reason analyze the production system status and autonomously formulate plan of actions using ai planning and reconfiguration algorithms as well as resource autonomy solutions3 adapt automatically modify hw and control systems to execute the formulated plans through the use of robotics and autonomous systems smart devices and adaptable mechatronics 4 collaborate seamlessly work with humans or other resources establishing a social industrial environment which exploits smart human machine collaboration user experience assessment and user centric workplace design 5 innovate expand its capabilities and openness via an open pilot network as well as links to local and international innovation ecosystemsconverging will demonstrate its results in the automotive aircraft production white goods and additive manufacturing products processing sectors
high performance hydrophobic suberin nanoparticles for the generation of liquidair biphasic droplets with application in food and therapeutics

an antibubble is a droplet of liquid with a shell surrounded by a thin film of gas antibubbles have many potential applications eg drug delivery with application in a clinical setting and the food industry the major challenge is to develop antibubbles with a long life time essential for industry usage the gas shell can be stabilized using hydrophobic nanoparticles to create a particle shell surrounding the air the use of particles instead of surfactants to stabilize dispersed systems is an attractive sustainable solution for the food industry our demonstration of the ionic liquidcatalyzed purification of the polyester suberin from plant materials in the form of hydrophobic nanoparticles led us to investigate their potential application for the generation of high performance antibubbles
innovative sorting facility for the circularity of aluminium scraps

as the second most widely used metal in the world only after iron aluminium plays a key role in realizing the circular economy and the climate neutrality of both eu and our world in essence aluminium has the potential to be a fully circular material that can be repeatedly recycled without losing its properties however many recycled aluminium scraps of eu are currently contaminated with highlevel impurities which make them not suitable for reuse this causes a loss of around one million tonnes of scraps per year in eu and hinders the achievement of circularity this project will develop an innovative facility for the automated sorting of highquality aluminium scraps the facility will be based on three innovative technologies ie singulation multisensor system and ejection it will be developed with an interdisciplinary approach that combines particle technology computational modelling advanced sensors artificial intelligence ai and automation through a close collaboration with an industrial partner reukema the developed technologies will be carefully validated and integrated into a sorting facility at an industrially applicable scale eg at least 4 tons per hour of clean sorted and specified scrap alloys the completion of the project will constitute a big advancement in the circularity of aluminium scraps and will contribute to the substantial reduction of resource consumption and greenhouse gas emissions
seaweed based market applications

seaweed is a valuable and underutilised resource that has large potential for exploitation in a variety of markets seaweed cultivation is a natural solution for mitigating climate change the european seaweed industry remains in its infancy and requires significant growth in order to become commercially viable seamark will utilise recent groundbreaking selective breeding technologies within eu seaweed crop genetics to increase biomass yield seamark aims to upscale circular ocean seaweed cultivation and landbased integrated multitrophic aquaculture imta systems and develop novel processing methods involving fermentation and biotransformation into twelve innovative seaweedbased products the entire value chain will be analysed for technoeconomic feasibility and socioeconomic impact seamark will also identify and quantify ecosystem services provided by seaweed cultivation this will feed into a strategic development plan for upscaling seaweed production and addressing the carrying capacity of seaweed cultivation in europe due to the need to build more resilient food systems and decrease reliance on fossilbased products it is necessary to grow the blue bioeconomy through seaweed cultivation and product innovation seamark will help fulfil the united nations sustainable development goals 3 8 9 12 13 14 by developing this industry and simultaneously providing a positive impact on people and the planet
teaching science in the colonial era knowledge weaponization and cultural integration from europe to the jesuit missions

the tescco project aims at offering a comparative study on the methods for teaching science implemented by the jesuits at the end of the 17th century during their missions in china and north america to show that the harmonization between religious motives and motives connected to cultural dissemination found in their activities couldnt have been possible without a serious and wider philosophical reassessment of the role of science and its teaching throughout europe this study will cast a new light on the domination strategies adopted during the colonial era connecting consistently for the first time the scientific developments of the early modern period with the many attempts of subjugation and cultural appropriation made at that time on behalf of a supposed superior and exclusive knowledge the interdisciplinarity of this project which combines the history of science and science teaching history of philosophy and sociology is further complemented by a theoretical part that aims at rising awareness of the overlooked connection between the foundation of science and how it is taught to others by promoting a healthy distinction between raw scientific data and the historical context in which it has been collected the tescco project has the ambition of becoming relevant nowadays as a starting point for a discussion on the role of science as a byproduct of the european culture and on how this assumption is seen in the exchanges with other culturesthis project hosted by ca foscari university of venice and by the department of philosophy at harvard university will be crucial to expanding my knowledge and my expertise as a researcher thanks to the collaboration with my supervisors and the exchange with other researchers involved in groundbreaking projects on early modern science it will also be a fundamental step in the development of my career helping me obtain a permanent position at ca foscari university or another european institution
cooling with electrocaloric polymers

cooling our food and houses requires today 20 of all the energy needed in the residential sector this share will grow to 40 by 2040 as a direct consequence of the world population increase and the global warming effect but the existing cooling technologies are overwhelmingly dominated by the vapourcompression systems which is a 150 yearsold technology relying on greenhouse gases and exhibiting an average efficiency around 50 the latter figure means that half of the energy used to run fridges and air conditioning ends up in waste heat we clearly need to come up with cleaner and more efficient cooling principles electrocaloric cooling has become a more and more realistic alternative to vapour compression cooling this principle is based on a reversible variation of temperature induced in specific materials when voltage is applied list recently showed that a few grams of electrocaloric ceramics can generate a variation of temperature of 209 k and a cooling power of 4 w besides electrocaloric polymers have a cooling potential one order of magnitude larger than ceramics this is what we intend to develop in this project with a clear assessment of scale up capabilities thanks to an ad hoc consortium hence arkema world leader in electroactive polymers will investigate electrocaloric polymers able to reach a variation of temperature larger than 5 k kemet european industrial partner will prepare thousands of multilayer capacitors based on optimized electrocaloric polymers the pi from ustutt who recently published the most efficient energy recovery circuit for electrocalorics will build electronic modules able to increase the efficiency of electrocaloric devices up to 60 and finally thanks to its extensive experience in making electrocaloric coolers list will assemble the multilayers and the electronic modules in a proofofconcept aiming at reaching a cooling power of 1 kw and an efficiency of 60 if successful this project will revolutionize cooling
european heterogeneous cloudedge infrastructures for next generation hybrid services

higher brings together 11 partners from industry and academia to jointly develop and validate opensource designs for highdensity rackscale systems capable of supporting cloud and edge services at scale in standardsbased data center environments starting with the arm rhea2 and riscv epac processors from epi and the riscv eupilot processor chip higher adopts the open compute project ocp server family of standards to build processor modules for computation and acceleration alongside a system securitycontrol module all operating with fullyfeatured operating systems and runtimes higher aims to design ocp server mechanics to provide modular rack systems incorporating reusable standardsbased infrastructure encompassing hardware lowlevel firmware and systems software ensuring trustworthy functionality for managing securing and controlling servers the projects opensource hardware and software outcomes will enhance european digital autonomy and facilitate wide adoption furthermore the project will assemble representative software stacks supporting a range of use cases including accelerated data processing and analysis for converged cloud and hpc platforms infrastructureasaservice with standardized management and monitoring platformasaservice facilitating largescale data processing for ml inference and data analytics and memory pool management at the server rack level with access control safeguards aligned with maturing cxl standards
continuous digitalized processes for producing biopharmaceuticals

biopharmaceuticals are essential for the medical treatment of diseases like immune deficiencies cancer and diabetes and provide an indispensable component to the health care system worldwide as showcased by mrna vaccines in the recent pandemic despite this success manufacturing is still based on traditional outdated batch production technologies and on process development procedures based on historical experience and empiricism leading to many inefficiencies like very long values of timetomarket there is an urgent need to introduce modern integrated continuous and fully digitalized production processes to also cope with the upcoming cell and gene therapies and the emerging personalized medicine i develop here revolutionary process development and operation methodologies to enable thisthese are based on a digital twin which includes the first continuous integrated and fully digitalized plant for producing mrna the engine are innovative hybrid models for each unit of the plant which are updated on real time through continuous learning techniques these provide the predictive capabilities needed for monitoring and control knowledge transfer scenario analysis and experimental planningi will develop a new generation of hybrid models and innovative machine learning algorithms and provide the experimental evaluation and validation of my methodologies other high precision continuous processes like flowchemistry for sustainable catalytic processes or microfluidics for the controlled synthesis of nanomaterials will benefit from these resultsi am a recognised pioneer in the scientific foundations of continuous operation in biopharma this inspired me in developing this disruptive digitaltwinbased methodology and cope with the associated high risk with about 110 phd students advised in my career and now active in academia and industry i know how to inspire a new generation of scientists with the novel science emerging from this project