Dragon09/odtu_chatbot huggingface dataset:
critical geopolitics of nuclear fuel supply in europe

how do countries build their nuclear fuels supply policies the ongoing political renaissance of nuclear power through the world raises concerns about european union states ability to fill their needs despite efforts to build a common strategy eu members follow diverging paths to secure their supplies however energy security studies are so far unable to explain this heterogeneity creating miscomprehensions between countries and illinforming energy policies first we lack any empirically informed works on the geopolitics of nuclear power second all theoretical frameworks studying supply security were built over hydrocarbons but if we want to decarbonize our societies we will first have to decolonize these tools from the grip of fossil fuels third while critical security studies have called for more spacesensitive approaches engagement with political geography theories remains limited geonufe aims at filling these gaps by questioning the variables behind the spatial heterogeneity of nuclear fuel supply strategies to do so i develop an innovative analytical framework bridging critical security studies and critical geopolitics through their ongoing turn to new materialist approach and assemblage geonufe will compare four countries france finland the uk and hungary following three steps 1 ill confront the current fossilfuel informed theories to actors of the nuclear sector to build the first ever analytical framework of objective supply security adapted to it and apply it to the four countries 2 ill identify the influence of eu membership by digging into how the euratom supply agency who is responsible for allowing supply contracts to member states produces and performs security 3 i will trace and compare the geopolitical assemblage which explains the supply strategies in each country expected results will provide essential knowledge of the geopolitical dimensions of energy transitions to better inform eu energy policies
the transversal social impact of gold metallurgy in ancient societies a diachronic approach from prehistoric iberia

goldenimpact aims to understand the social impact of gold technology implementation in all sectors of society and surpass outdated traditional narratives that solely understand gold as a consolidator of elite power hence the project targets the study of gold production by 1 characterising existent technological traditions 2 understanding the social consequences of metal crosscraft interactions affecting gold production and 3 evaluating the extent and degree of novelty of the structural changes necessary to sustain gold production iberia was selected as case study 31001500 bc for being an archaeologically rich area with an autochthonous development of metallurgy and outside of the traditional research loci of ancient gold technology in eurasiato accomplish these objectives this project uses a radically interdisciplinary methodology that combines knowledge from archaeology anthropology and geology with computational tools r qgis and materials science techniques optical microscopy pxrf icpms to analyse selected gold items and deposits as a result it will be possible to reverse engineering and socially contextualise ancient gold production strategies and explore the links between technological and social change from a previously overlooked perspective ie gold production this will contribute to resignify gold as a symbol of the achievements of nonelite people and ultimately generate a more balanced narrative within the european history of technology taking into account all society sectors and europes eastern periphery
digital finance reaching new frontiers

a competitive european financial sector is vital for the modernisation of the european economy across sectors and to turn europe into a global digital player we have identified the five most pertinent areas within this domain towards a european financial data space artificial intelligence for financial markets towards explainable and fair aigenerated decisions driving digital innovations with blockchain applications sustainability of digital finance for this purpose we have gathered an internationally recognized network consisting of nine leading european universities wu vienna university of twente bucharest university of economic studies babesbolyai university bern business school kaunas university of technology university of naples university of poznan university of kaiserslauternlandau all ranked among the top 200 universities globally in their fields three major international corporations swedbank deutsche bank and raiffeisen bank with a significant rd presence across europe two smes cardo ai and royalton partners being some of the most innovative ones in their field three large and internationally renowned research centres arc greece eit digital and fraunhofer institute germany the bank for international settlements and the european central bank as one of the seven principal decisionmaking bodies of the european union and the euratom as well as one of the worlds most important central banks the results of the research carried out within digital are of substantial interest to three leading europeanwide research networks that our members either lead or serve on the management committee for cost action ca19130 240 researchers across 39 european countries ecmi and the european consortium of innovative universities 13 european universities it is only through a network that incorporates the expertise of all distinct shapers of the financial industry that we can see a comprehensive shift towards innovation and digitalization of a sector that is notoriously averse to change
universal description of the bose gases

in unibogas my aim is to prove universal expansion formulas for the low energy levels of the dilute bose gases showing their dependence on just one parameter namely the scattering length of the potentials between the particles i am going to work out to which order of precision of the expansion the universal description still holds and for which kind of systems the classification of the systems that satisfy the universality is obtained through studying the expansions in three directions by paradigmatic examples i am going to evaluate the energy for systems with potentials with repulsive and attractive parts i am going to approximate the energy of systems composed by two kinds of bosons by the energy of effective nonlinear models and i am going to evaluate the low energy levels of the hardspheres hardcore potential systemthe methodology used includes both the improvement of preexisting techniques in the bogolubov theory and the introduction of new methods of localization semiclassical analysis and variational methodsother than on mathematical physics the results of unibogas will have an impact also on disciplines like functional analysis experimental physics and quantum chemistry for the bose gases and will contribute to further understand the phenomenon of bose einstein condensation
experimental aircraft for european leadership in aviation

the objective of exaelia is to investigate and to answer the needs for novel flying testbeds for derisking the development of disruptive future longrange aircraft accelerating the reduction of all aviation emissions and its climate and environmental impacts in 2050exaelia investigates through advanced multidisciplinary digital methods the potential emissions reductions of longrange air traffic offered by promising blended wing body aircraft configurations and by hydrogenpowered tubeandwing configurations including their constituting radical new technologies critical uncertainties are identified in particular those requiring flight validation for derisking the future aircraft development for those flight test requirements which go beyond the capabilities of existing assets novel flying testbeds are developed towards their preliminary design and demonstrated to answer the flight validation needs efficiently combining these needs in potentially costly largescale modular flying testbeds roadmaps are prepared for the further development of the exaelia flying testbeds and their use in the development of the future longrange aircraft entering into service before 2050 with a maximum contribution to reducing aviation impact and emissions 49 of air transport system emissions in 2019 came from long range aircraft operational and business plans for these indispensable test bed assets are provided as wellthe exaelia consortium consists of the major european research centres and academia in future aircraft conceptual design and analysis flight testing and flying testbed development and 4 smes all with a strong record in collaboration an advisory board including european aircraft and engine manufacturers and further industries will provide guidance to achieving the objective and to obtaining their support to the roadmaps the total grant request of this 42month action is 16 233 889 euros
integrating terrestrial and aquatic archaeozoological studies venice and the northern adriatic lagoons between antiquity and the early middle ages

the inter aquas project aims to investigate humananimalenvironment relationships at the romanearly medieval transition along the northwestern adriatic coast by highlighting elements of continuity and discontinuity the project aims to contribute precious knowledge to the archaeology and history of this transitional period the project will analyse archaeozoological assemblages from three studyregions the venetian lagoon the maranogrado lagoon and the coast of romagna these regions are characterised by the presence of wetlands with lagoons rivers and canals influencing the nature of human settlement and activities the archaeology of the late antiquity and middle ages in the northwestern adriatic represents a very active field of research current archaeozoological analyses however are sitespecific while largescale reviews touch these regions only lightly and marginally without focussing on their peculiar environmental contexts the chronological and spatial comparisons proposed by the inter aquas project the combination of terrestrial and aquatic faunal studies and the functional implementation of biometrical and stable isotope analyses will provide a holistic approach taking into account the complex changing relationships between humans other animals and the environment my experience in archaeozoology and in particular my familiarity with biometry and the romanearly medieval transition in europe make me the ideal candidate to conduct a project such as inter aquas ca foscari university of venice is a leader in the study of the late antiquity and middle ages in italy and the project will ultimately fill the existing gap in largescale and methodologically targeted faunal analyses in addition to informing on key aspects of past economies and environments this study will boost my knowledge on the archaeology and history of the periods considered and substantially advance methodological skills required to optimise my career prospects
synaptic resilience in tauinduced neurodegeneration

dementia is an enormous burden on society patients require lifelong care and there is no cure or symptomatic treatment at early phases dementia is closely associated with synaptic degeneration and this correlates well with tau pathology in 20 tauopathies interestingly historic observations in hamsters and squirrels show that when they enter into hibernation they also display tau pathology and synaptic loss pathologists have pointed to these similarities however there is an important difference synaptic loss is progressive in dementia but reversible in hibernating animals capitalizing on recent technological advancements i will unravel the mechanisms of this remarkable yet understudied process of synaptic remodeling in hibernation and then use the pathways that reverse synapse loss in hamsters to counteract tauinduced synaptic decline in models of dementia we will achieve these goals by first defining and studying the molecular and cellular drivers of synaptic remodeling during cycles of hibernation this is based on innovative spatial transcriptomic and synaptic proteome analyses in hamster brains we will then identify the human homologues of the hamster genes that reverse synaptic loss following hibernation and use a selection strategy in xenotransplanted human neurons and functional assays on customdesigned multielectrode arrays to isolate genes rescuing tauinduced neurodegeneration this approach is bold but feasible my lab has a record of accomplishment in synaptic and neurodegeneration research and we already have strong preliminary work implicating specific presynaptic pathways in the types of taudependent synaptic remodeling that we will study here the gain is that we will uncover the mechanisms of a remarkable process of synaptic resilience and apply this to rescue the synaptic loss in neurodegeneration this project will define a conceptually new and unexplored class of therapeutic targets to tackle tauinduced neuronal decline
ecoloop

ecoloop project develops and demonstrates a set of solutions to optimise the combination of different energy distributed sources biogas biomass agripv geothermal meeting the local needs for electricity heating cooling transport and waste and land management in rural areas fostering regional development and creating benefits for farmers and foresters the project solutions will focus on promoting the reduction of carbon footprint in rural areas by means of the higher penetration of distributed renewable energy sources selfconsumption and an optimal agriculturalforest waste management while creating positive effects in biodiversity and soil health and reducing the risk on groundwater contamination following this approach ecoloop objectives areto optimise the production of biogas from agriculture and forestry wastes in situ to combine in an efficient and sustainable way different distributed renewable energy sources biogas biomass agripv geothermal meeting the local needs for electricity heating cooling transport and waste and land management in rural areasto develop innovative renewablebased agricultural protocols and advance bioproducts to increase sustainability and circularity while creating positive effects on biodiversity and soil health and groundwater pollutionto foster regional development in rural areasecoloop project will move towards a circular economy in rural areas focusing on agriculture and forestry sectors contributing to job creation gender equality biodiversity and climate resilience and adaptation all the benefits provided by ecoloop solutions will be demonstrated in 4 pilot sites in spain estonia bulgaria and slovenia involving different forest and agriculture natural conditions climate soils size and types of crops trees management techniques degree of mechanisation geographic location and socioeconomic factors and considering the interaction of different types of energy sources
effective codelivery of therapeutic peptides and intestinal permeation enhancers using a double pickering emulsion oral delivery system

therapeutic peptides tps are one of the fastest growing classes of therapeutics with clinical applications in severe andor chronic diseases like cancer therapy hormonal or immune disorders and infectious or metabolic diseases to date most tps can only be administered by invasive injection which greatly influences treatment costs as well as patient compliance and wellbeing as eg diabetic patients rely on regular insulin injections oral delivery of tps poses a convenient alternative to circumvent these problems but it is highly challenged by i the harsh gastric environment detrimental to tps and ii the poor permeability of the intestinal epithelium to tps to tackle these problems i propose a novel oral delivery system for tps based on a unique gastric stable pickering double emulsion which is able to i protect tps from degradation in the gastric environment and ii codeliver hydrophilic tps and hydrophobic permeation enhancers pes to the absorption site the intestinal epithelium surface simultaneous codelivery of tps and pes is crucial but not often achieved as key deliverables orapickering will establish pickering double emulsions for the encapsulation of hydrophilic tps and hydrophobic pes explore their stability under gastric conditions and confirm their efficacy and safety for intestinal tp delivery in vitro and in vivo to implement orapickering i will join forces with prof nielsen from ucph combining my background in material and interface sciences with her expertise in tp delivery and intestinal permeation models and mechanisms i consider this the ideal environment for my further career development to learn relevant techniques for drug delivery and gain further experiences to emerge as an independent group leader in summary orapickering provides a novel avenue for oral tp delivery and thereby contributes to a more facile safe and costeffective administration of tps in the future
clinical validation of the first implantable sensor system for wireless detection of stent occlusion restenosis

globally over 237 million people suffer from peripheral artery disease pad an abnormal narrowing of the arteries the implantation of stents spiral wire protheses is the firstline therapy for pad with 35m stents implanted worldwide every year restenosis the gradual reclogging of the blood vessel after stent implantation is a major problem leading to high morbidity and mortality which occurs within 6 years after implantation in 23 of all cases and is often detected when it is too late more frequent surveillance of pad patients to avoid unnecessary amputations and death is an unmet clinical challenge vesselsens is developing the stentguard a smart therapeutic monitoring device that enables rapid low cost early diagnosis of restenosis noninvasively and reliably this device allows stent monitoring at high frequencies with low cost by nonspecialist medical practitioners solving the problem of unchecked disease progression and saving the eu economy over 1bn year
avifauna in archaeoecological networks

we love birds but probably do not worry enough about our relationship to them across the world we are threatening their critical ecosystem functions including birds positive impact on our wellbeing and poultry has become our favourite meat yet industrialscale breeding has consequences for human and bird health arguably this lack of concern is due to our ignorance of the deep historical roots of these relationships our interaction with birds for their plumage eggs meat song or spirit extends back to prehistory at the same time avifauna responded to climate shifts and to our modifications of the landscape this has created a tangled archaeological record which makes understanding birdhuman relationships all but impossible building upon and moving beyond my expertise in biomolecular archaeology aviarch will explore from a birds eye view the transition to agriculture in epipalaeolithicneolithic southwest asia and the emergence of urban life and trade routes in bronze age crete aviarch will reveal the variety of birds in past human systems by using new techniques for the identification of avifauna integrating zooarchaeology palaeoproteomics and ai my sites have been carefully chosen to target biodiversity hotspots with a rich archaeological record intersecting socioecological changes of humanbird relationships we will combine ecological morphological and behavioural traits for each bird to produce the most refined exploration of humanavian relationships yet attempted in archaeology using network analysis and underpinned by multispecies theory aviarchs archaeoecological models will discover how environmental shifts affected people and anthropogenic and climatedriven changes affected birdsby transforming the ways in which past birdhuman interactions are studied aviarch promises to improve human adaptivity avian conservation strategies and make us worry and marvel about these beautiful creatures a little more
exploiting the multifunctional properties of polyphenols from wastes to high value products

phenocycles is addressing the environmental concern derived from agroindustrial wastes proposing their exploitation for obtaining important bioactive molecules polyphenolic compounds pp to be utilized for different purposes with a typical circular economy approach phenocycles aims at exploring innovative uses of pp and at validating methods for their extraction with a green chemistry approach pp extracted from agroindustrial wastes grape apple berry pomaces and herbs with therapeutic value will be purifiedfractionated with pilotscale nanoultrafiltration membranes to recover different pp fractions to be employed in four distinct sectors human health synthesis of substances for photodynamic therapy pdt and drug delivery dd development of innovative phytocarrier systems formulation of pp loaded micronanoscale systems development of new food supplements nutraceutics and hypoallergenic cosmetics plant production ppbased nanomaterials for plant protection against soilborne pests to increase plant resistance to stresses impacting on plantorganisms trophic interactions environment protection use of pp as sensitizer or intermediate in the synthesis of materials for water disinfection and advanced oxidation processes aops material sciences synthesis of metal based oxide nanostructures useful for photocatalytic applicationsto foster future exploitation of the innovations a thorough assessment of the stakeholders perception of their adoptability will be performed applying a participatory approach together with several innovative dissemination activities based on visual media the interdisciplinary exchanges planned in phenocycles are thus expected to increase the knowledge of researchers particularly young ones on the different methods utilized by the partners fostering further developments in medicine pharmacology crop protection food preservatives nutraceuticals cosmetics and other industrial applications
reconstructing the pagan religion of tibet

buddhism was introduced to tibet in the 7th century ce and became the official national religion in the 8th a small percentage of tibetans are followers of a religion called bön which its adherents bönpos and buddhists alike consider to be the countrys indigenous faith bön came to acquire many buddhist features but retained a strand of more archaic traditions since there is no evidence that these traditions were actually called bön prior to the establishment of buddhism we refer to them collectively as tibetan pagan religion until now all we knew about this religion came from a small number of early mainly 811th c manuscripts from the silk road a small cache from southern tibet and some ritual narratives in the literature of reformed bön this situation changed dramatically in 2005 with the discovery of a large number of manuscripts constituting the ritual repertoire of a class of priests called leyu in the sinotibetan borderlands although facsimiles of some 35000 folios of these manuscripts have now been or are due shortly to be published in china other than the pi and members of his team no one has worked on them owing to difficulties of script language and the concepts conveyed preliminary investigations suggest that these texts contain genuinely archaic nonbuddhist rituals and narratives closely resembling those of the early sources that are already known using stateoftheart computational humanities tools such as handwritten text recognition and natural language processing in conjuction with the methods of philology comparative religion and anthropology pagantibet proposes to undertake a systematic study of the leyu manuscripts producing a searchable database of the entire corpus an annotated catalogue of its contents as well as translations and extended summaries of a selection of its works to provide the firstever reconstruction of tibetan pagan religion