Dragon09/odtu_chatbot huggingface dataset:
redefining the landscape of ammonia electrooxidation utilising molecular electrocatalysts

fuel cells represent highly efficient and nonpolluting power devices that convert the chemical energy of a fuel into electrical power ammonia as a fuel is considered a potent alternative to the commonly used hydrogen because it has a lower cost per unit of stored energy and benefits from a wellestablished production and distribution infrastructure the electrochemical nh3 oxidation reaction eaor typically relies on ptbased electrocatalysts due to their low overpotential and remarkable selectivity for n2 however their susceptibility to durability problems exacerbates their already high cost and limited availability a few recent studies have reported molecular eaor catalysts but evaluate them under homogeneous conditions which are rarely relevant to energyrelated applications to make feasible catalytic systems out of molecular catalysts their heterogenisation on electrode surfaces is necessarywithin the msca postdoctoral fellowship elmar i aim to construct catalytic films for eaor by encapsulating nonnoble metal molecular complexes in carbonbased supporting materials those hybrid electrocatalysts will undergo electrochemical assessment to determine their efficiency and durability and will be compared to a reference ptc catalyst the performance of each electrocatalyst will be optimized by tuning the microenvironment of the molecular complex inside the film and rationalized based on spectroscopic and spectroelectrochemical investigations overall i aspire to establish an exemplary methodology for constructing optimizing and rationalizing electrocatalysts based on simple nonnoble metal complexes my ultimate goal is to create robust eaor catalysts capable of competing with ptbased ones this endeavour can significantly contribute to the development of fuel cell technologies that are expected to play an important role in the decarbonization of the eus energy system
core dynamics on millennial timescales

paleocore will provide the first comprehensive observational constraints on the dynamics of earths core on multicentennial to millennial timescales such constraints are essential to understand the core processes responsible for the rapid decay of earths dipole field strength over the past century and to forecast future field changesgenerated through convective motions in the liquid iron core earths magnetic field acts as a shield against harmful cosmic radiation and plays a crucial role for the habitability of our planet the past two decades of satellite monitoring of the magnetic field in combination with major advancements in numerical simulations of the geodynamo have generated a wealth of knowledge on relatively rapid processes in the core however due to the lack of reference data with adequate resolution the dynamics of the core on timescales longer than the convective overturn time 130 years are still poorly understood observational constraints of core dynamics on these timescales are crucial to evaluate proposed driving mechanisms of the geodynamothrough recent technical innovations models based on indirect paleomagnetic observations of earths magnetic field are providing information on past field changes with unprecedented resolution these models suggest that the recent dipole decay is part of a millennialscale recurrent pattern associated with weak field anomalies like the presentday south atlantic anomaly the aim of paleocore is to construct the first ever integrated corefield coreflow model over millennial timescales to study such ancient analogues and reveal the underlying core dynamics responsible for driving these changes this will be achieved through a combination of i strategic paleomagnetic data acquisition and key modelling innovations solving bottlenecks in the current approach ii incorporation of independent radionuclide data and iii adaptation of data assimilation algorithms for paleomagnetic data
dependence of nucleosome transactions on sequence

eukaryotic genomes are packaged into chromatin which restricts access to the dna key genomic processes therefore involve the rearrangement of chromatin by atpdependent chromatin remodelling enzymes remodellers which actively place and reorganise nucleosomes the precise positioning of nucleosomes plays a crucial role in regulating transcription replication and dna repair dna sequence impacts this nucleosome architecture by affecting the activity of remodellers however what mechanisms underlie this critical sequence dependence in remodelling remains unknown here we propose to address this longstanding question based on the following rationale the nucleosome represents a highly constrained substrate with many histonedna interactions remodeller action therefore involves multiple sequential catalytic cycles and a series of transient structural intermediates of the nucleosome we hypothesise that the nature and stability of these intermediates determine the effects of dna sequence on remodelling probing this hypothesis requires the direct observation of transient remodelling intermediates as a function of sequence at the genome scale which cannot be achieved with currently existing methods we aim to address this major challenge by developing a novel highthroughput platform that combines for the first time singlemolecule measurements of complex dynamics with nextgeneration sequencing this platform will enable the comprehensive profiling of sequencedependent processes at the singlemolecule level we will leverage the platform in combination with molecular simulations and in vivo experiments to gain groundbreaking insights into the mechanisms of sequencedependent remodelling and its role in the establishment of chromatin architecture ultimately we expect to decipher how the dynamic landscape of nucleosome intermediates encoded in the sequence wrapped around the histone core impacts nucleosome function in vivo
the ontogenesis of abstract thought higherorder representations in the maturing brain

thinking about the worldwhat is and what might beis fundamental to human life the foundation for this worldunderstanding is laid in the preschool years of childhood around the age of 4 children begin to reason not only about the real world but also about what is possible or what people believe about the world the acquisition of these abstract representations of the world is reflected in a major developmental breakthrough across domains of human cognition the mechanisms that drive this breakthrough however are unknown represent aims to clarify the cognitive and neural foundation of how we in early childhood come to represent the world in abstract termsbased on novel findings i propose that the maturation of a core network of the human brainthe default mode networkallows children to decouple representations from sensory input and thus entertain several different representations of the world simultaneously increased connectivity to prefrontal regions and coupling to other cognitive networks are proposed to enable children to compute the relation between these representations providing the foundation for abstract reasoningrepresent will for the first time connect multivariate and connectivity methods in early childhood combined with novel task designs to reveal the precise neural representations that underlie reasoning about a different beliefs and b possibilities and their functional interplay in maturing networks of the brain wp1 targets change in these representations and networks in preschoolage as mature abstract reasoning emerges wp2 aims to reveal how infants compared to preschoolers represent situations involving multiple beliefs or possibilitiesthis new approach will allow represent to resolve longstanding questions of how uniquely human abstract thought develops and how it is implemented in the human brain this has myriad implications for developmental and cognitive theory and for our understanding of the human brain
dynamic mapping of epigenetic regulation during embryogenesis using in vitro stem cell model

this proposal aims to decipher the dynamic regulatory landscapes of chromatin modifiers during embryogenesis in particular i envision to unravel their mechanism of action at unprecedented resolution using singlecell based techniques and provide novel insights on the molecular deregulation that leads to diseases such as cancer the originality of this approach is to simultaneously address the function of hundreds of chromatin modifiers in early development by using a higher throughput stem cellsbased in vitro screen in order to achieve this we will take advantage of a recently established culture system that faithfully recapitulates embryonic development up to somitogenesis in the dish the combination of various cuttingedge techniques with this model cas9based screening targeted protein degradation low input cutrun and single cell rnaseq and our sophisticated computational strategies will allow a precise understanding of how various chromatin regulators act on specific targets in individual cell in particular we will resolve gaps of how two essential global modifiers polycomb repressive complex 1 and 2 cooperate to regulate distinct cell identity decisions ultimately we will hope to reconstruct the hierarchal dynamics of chromatin regulators at a temporal and spatial resolution of single cells through embryogenesis the result of this action will be shared with scientific community by openaccess peerreviewed journals conferences analytic codes and sequencing data and with general public through open science days the meissner laboratory will provide the ideal environment not only to carry out this project but also expand my scientific expertise and train my skills to better prepare me to become an independent group leader in the future
targeted delivery of lipid nanoparticlemrna formulations modified with ligand pattern to dendritic cells based on dna origami

mrna vaccines have gained considerable attentions in prevention and treatment of virus infections cancer and genetic diseases especially in the application to the covid19 pandemic in recent years due to the immunogenicity and instability of mrna the in vivo delivery of mrna plays a crucial role in vaccine efficacy among various materials lipid nanoparticles lnps have shown to be one of the most potent carriers for mrna delivery and successfully enter the clinic to further improve vaccine efficacy dendritic cells dc uptake can be optimized by decorating mannose ligands on lnpmrna formulations for targeted vaccine delivery however the effect of ligand density spatial distance and organization pattern on cellular uptake remains poorly understood due to the addressability of dna origami nanoparticles and small molecules can be spatially organized into prescribed pattern with nanoscale precision therefore we propose to develop designed ligand patten on lnpmrna formulations by transferring ligand pattern distributed on dna origami to lnps with ligands modified on surface lnpmrna formulations will be used to investigate the effect of ligand pattern on dc uptake which is not accessible to other targeted delivery system the results of the project will promote the development of vaccine delivery field in addition it will influence the health care and biomaterial industries which are central to europes ongoing and future economic success
user driven climate applications empowering regional resilience

climempower will empower five southeuropean regions with high climate change cc risk and exceptionally low adaptive capacity to enhance their ccresilience establish the regional communities of practice cop and cocreate the resilient development strategies adapted to the regional needs and potentials we will achieve this through combination of userdriven climate applications capacity building and best practices transfer from other european projects and regionsthroughout the project the climempower team will aid the regional administration in organizing the regional cops where representatives of quadruple helix stakeholders will discuss their climate adaptation needs and capabilities assess potential pathways towards ccresilient societally just and sustainable future and elect sustainable and ccresilient regional development pathways that are best suited to their needs and capabilities this activity will be supported by provision of the data driven decision support services for strategic ccadaptation planning as well as through provision of easy to understand educational materials illustrating the cc risks and possible technological natural and societal adaptation options and strategies explaining the use of the project tools as well as knowledge transfer on existing data tools and best practices in climate adaptation from successful eu projects and regions with higher adaptive capacityclimempower will develop new generic interface to c3s climate data store data driven cchazard and risk assessment services and semisemiquantitative screening services allowing the users to compare different adaptation strategies these services will primarily rely on open data and open service infrastructure and on crosslinking of such data with data that can be sampled locally during the project to complement the paneuropean data improve granularity or to validate the predictions
neuronal control of fine movement components of egg laying in fruit fly

a short summary to be written shortlyinsect reproduction has a large impact in human wellbeing through the dissemination of disease and crop failure here we propose to study insect egg laying using drosophila melanogaster as a model system we will focus on the ventral nerve cord and its role in executing egg laying behaviour commands we will take advantage of lines previously generated in the laboratory that label small groups of neurons in the ventral nerve cord to establish how different neurons contribute to egg laying motor elements and explore how they communicate with each other and other identified egg laying neuronal elements to coordinate the execution of the different egg laying steps for this we will pursue the following aims aim1 development of automated tracking of each element of egg laying behaviour this will allow a precise quantitative and fast description of behavioural phenotypes aim2 probe the contribution of different motorcontrolling neuronal populations to different elements of egg laying behaviouractivation phenotypes will be recorded classified and clustered for each ventral nerve cord line aim3 establish the connectivity of different neuronal populationsthe power of drosophila genetics will be used determine through anatomical and functional means the connectivity between different sets of neurons including descending neurons from the brain and other local ventral nerve cord neurons we will also determine how octopamine modulates the functional connectivity between the neuronswith the results of this project we expect to produce important insights into the mechanisms of control and execution of egg laying behaviour
engineering lipid nanoparticles to target and escape the endosome deliver their cargo and perform better as breast cancer therapies

there is a strong need for personalised genetic medicines for the treatment of advanced breast cancer lnpmrna nanomedicines have already been proven as safe and cost effective in the sarscov2 vaccines however cancer treatments often require i repeat dosing ii controlled immune response iii adaptability to combat drug resistance there are several lnprna clinical cancer trials ongoing many of which have reported challenges with toxicity performance and specificity off target effects for an lnprna cancer therapeutic to function they need to localise in the correct organ enter the cancer cells and escape the cellular endosomal processing pathway to release their rna cargo in current lnprna formulations only a small fraction 10 of lnps successfully escape the endosome however these null lnps can still contribute to toxicity which places huge restrictions on their clinical application and performance the aim of this proposal is to provide mechanistic insight into the endosomal escape of lnps and use nanoscale engineering to target the endosome and improve lnp endosomal escape this is particularly relevant in breast cancer as the majority of lnp systems are optimised for liver applications and designed to undergo fusion under healthy endosomal conditions in breast cancer the composition lipid protein and environment ph of the endosome differ significantly between healthy and cancer cells objectives use omics approaches to quantify key differences in the endosome in healthy and breast cancer sub type cells and develop breast cancer sub type endosome models design lnps with enhanced fusion to endosomes using i lipid composition ii protein protein lipid interactions iii ph mediated fusion validate novel lnps with increased endosomal fusion and lower toxicity for breast cancer treatment
earlylife urban environmental exposures and childhood multimorbidity an exposomewide approach

urbane addresses an important and timely question how does the urban environment impact the developmental origins of multimorbidity neurodevelopmental cardiometabolic and respiratory adverse health outcomes are increasingly prevalent at young ages with diseases such as obesity and asthma affecting up to four out of ten children in europe multimorbidity the cooccurrence of two or more health conditions in childhood is thus becoming a major public health problem with short and longterm consequences although it is well known that environmental hazards play a role in the development of diseases the contribution of the complex environment in which we grow up and live on the development of multimorbidity remains unclear urbane addresses this knowledge gap the project will leverage the resources of the portuguese populationbased birth cohort generation xxi and follow an exposomewide approach to the study of urban environmental impact on childhood multimorbidity for that the project will use a wide range of geospatial urban exposure data eg air pollution and characteristics of the urban natural and built environment and multiple adverse health outcomes eg high blood pressure obesity asthma behavioral problems collected at the vulnerable early stages of the lifecourse pregnancy and childhood the project will explore socioeconomic status and gender differences and also assess whether dna methylation changes and dysregulation of hormone leptin explain the urban environmental impact on multimorbidity urbane will contribute to the discovery of urban environmental priorities vulnerable subpopulations and aid in the identification of underlying mechanisms urbane is highly interdisciplinary and fosters knowledge exchange the project aligns with major eu strategies related to the urban environment and noncommunicable diseases prevention and thus its results are expected to be of high relevance for researchers policy makers and society
an anthropological study of conspiracy theories from marginalized standpoints

conspiracy theories acquire a particular significance when they are voiced by social actors who are socioeconomically disadvantaged andor subjected to processes of dispossessiondecript will introduce theoretical and methodological innovations into conspiracytheory studies to expand current understandings of the nexus between conspiracy theories and socioeconomic disadvantage comparing four paradigmatic communities subject to longstanding or newlyemerging processes of marginalization across four different countries of western europe the project seeks to understand the conflictual dimension of conspiracy theories in the online sphere and in everyday offline interactions the conditions that make conspiracy theories acceptable or appealing among disadvantaged groups connections and disconnections between the communicative intentions of online conspiracy propagators on the one side and the pragmatic uses of conspiracy theories by ordinary social actors in everyday life on the other theoretically decript will introduce into conspiracytheory research 1 the philosophical tradition of pragmatism with its linguistic and sociological legacies in order to focus on social actors pragmatic uses of conspiracy theories to justify their practices andor produce specific effects and 2 a feminist epistemological lens which examines processes of knowledge production and circulation by paying attention to different forms of oppression in order to expand current understandings of the conditions of acceptability of conspiracy theories among lowstatus groupsmethodologically it will be the first comparative study whose empirical focus will encompass both conspiracy narratives and the narratives opposing them across both digital and nondigital environments by combining critical discourse analysis of online sources and feminist ethnography
circularprorobust ai and robotics for the weee recycling sector

the world is facing a tsunami of ewaste in 2019 7m tonnes of screens and monitors were disposed of un equivalent to 3bn of valuable commodities including crms if recycled properly fpd recycling led by an experienced team of innovators offers the circularpro a deep tech solution with intelligent automation and robust ai technologies to disrupt the flat panel display fpd recycling industry and beyond it will capture both reuasable components and crms for onward remanufacturing while managing toxic materials circularpro promotes crm recovery and reuse by certifying carbon credits based on reduced emissions and capturing data insights our innovation is a firsttomarket holistic solution creating a circular economy for fpds and recyclers we offer circularpro on a technologyasaservice model realizing new and sustainable income streams for recyclers its time to look at ewaste as a source of valuable materials and to capture its circularity with circularpro
somowalk communicating walking movement through sonification

in the eu stroke is the second most common cause of death and a leading cause of adult disability affecting the ability to walk in 6080 of people suffering a stroke in 2017 the cost associated with stroke was estimated at 45 billion as populations continue to live to an older age the corresponding costs are expected to increase dramatically new noninvasive motor learning techniques based on sensorybased rehabilitation are needed movement sonification implies a translation of movement signals into sound thus allowing communication of movement performance through sounds the longterm goal of the present project is to open new avenues for introducing a new sensory rehabilitation approach based on sonification which will allow for inducing body illusions and creating virtual environments treating motor disorders as well as for inducing changes in distorted body representation after a brain injury to date none investigated the impact of sonification associated with a walking movement on the motor and sensorimotor cortex on a neural level eeg can be used to measure motor learning and bodily sensory integration which is linked to body representation our shortterm goal is to develop a deeper characterization of the type of sounds that can be used for motor learning through sonification and how this will impact the sensorimotor and motor cortex focusing on the rehabilitation of the walking ability the project has the following specific aims 1evaluate the impact of sonification on walking ability as indexed by neural markers on the sensorimotor and primary motor cortex in healthy subjectswp2 2characterize the specific sounds that will be tested for walking rehabilitation through an interactive shoe interface system in patients with strokewp3 3investigate the possible correlations between the improvement in gait parameters and changes in body representation and bodily experience in patients with stroke when using sonificationwp3