Dragon09/odtu_chatbot huggingface dataset:
multisystem imaging of wholebody emotion circuits with totalbody positron emission tomography

the goal of the totalbody project is to establish the interacting biological networks supporting human emotions and their disorders across the brain and periphery using novel totalbody positron emission tomography pet approach the bodytobrain axis maps visceral signals onto emotions driving complex motivated behaviours negative emotions are risk factors for cardiovascular diseases cvds conversely cvds are associated with anxiety highlighting the link between negative emotions bodily functions and somatic health systemslevel interaction between brain and peripheral organs could thus be a key pathway underlying psychiatric disorders but it remains poorly understood totalbody tackles this question from groundbreaking viewpoint by implementing novel totalbody pet approach for measuring the physiology of the emotion circuits across the brain and body creating an innovative multisystem biology approach for studying emotions we simultaneously map activity in the brain and peripheral organs during pharmacologically and psychologically induced emotions in a large sample n240 of healthy volunteers and patients with generalized anxiety disorder gad links between cvds gad and wholebody emotion circuit activation are mapped in a clinical study involving 300 patients with suspected cvd the data are analysed using stateofthe art multiorgan modelling framework developed in the context of the project advanced pattern recognition techniques implemented on the whole dataset 540 subjects are used for discerning the centralperipheral pathways associated with future onset of anxiety and cvd anxiety and cvds constitute a major burden for health and wellbeing worldwide this unique largescale analysis of the centralperipheral axis of anxiety and cardiac functioning enables delineating biological and psychological mechanisms that generate the central and peripheral anxious state and burden the cardiovascular system predisposing individuals to cvd
mitochondrial precursor proteins in the cytosol as major determinants of cellular health

mitochondria are made of 800 to 1500 proteins which represent up to 30 of the cellular mass owing to their posttranslational mode of import mitochondrial precursor proteins explore the cytosol before they are imported into mitochondria these reactions are of utmost importance for cellular functionality since cytosolic precursors pose a major threat of cellular proteostasis and are major drivers in aging and for the pathogenesis of neurodegenerative diseases still the biology of cytosolic precursors is largely elusivein vitro import assays governed the experimentation platform of the mitochondrial community which enabled exquisite breakthroughs in understanding translocation but are unsuited to elucidate cytosolic reactions mitocyto aims to break out of these experimental walls to elucidate the biology of cytosolic precursors with an interdisciplinary research team that leaves the comfort zone of biochemistry to utilize genetic and cell biology approaches but also develops novel cuttingedge techniques from high throughput approaches through microfluidicsassisted microscopy to synthetic biology from this innovative combination detailed mechanistic insights into three so far largely elusive aspects of cell biology will be possible for the first time 1 what are the cytosolic interactors of mitochondrial precursor proteins 2 what are the direct and indirect physiological consequences of cytosolic precursor accumulation 3 how does the rerouting of mitochondrial proteins to the nucleus control growth and fitness of eukaryotic cellswe are convinced that mitocyto will break grounds to a comprehensive understanding of how eukaryotic cells maintain a healthy proteome over a lifetime despite fluctuating metabolic conditions while these goals are conceptually deeply rooted in a comprehensive understanding of basic biological questions they are of immediate relevance for cancer cell metabolism neurodegeneration and aging
secure design and deployment of trusthworthy continuum computing 6g services

rigourous project aspires to identify and address the major cybersecurity trust and privacy risks threatening the network devices computing infrastructure and next generation of services rigourous will address these challenges by introducing a new holistic and smart service framework leveraging new machine learning ml and ai mechanisms which can react dynamically to the everchanging threat surface on all orchestration layers and network functions rigourous new smart service framework is capable of ensuring a secure trusted and privacypreserving environment for supporting the next generation of trustworthy continuum computing 6g services along the full deviceedgecloudcontinuum on heterogenous multidomain networks this includes establishing compliance with the design of software sw protocols and procedures as well as aigoverned mechanisms to cope with the securityrelated requirements in the full devops lifecycle from the service onboarding up to the day2 operations further the devops lifecycle spans from the prevention and detection of anomalies andor intrusions at different levels physical or cyber based on violation of policies or rules up to their mitigation and policy enforcement it also comprises the incorporation of the human factor starting from the design until the humanintheloop concept in the whole orchestration additionally extensive research devoted to realizing advanced security enablers is carried out to bring automation and intelligence to the smart but also secure orchestration conceptin brief rigourous targets the following key objectivesholistic smart service framework for securing the iotedgecloud continuum lifecycle managementhumancentric devsecopsmodelbased and aidriven automated security orchestration trust management and deployment advanced aidriven anomaly detection decision and mitigation strategiesdemonstration of a set of industrially relevant use cases in operational envi
unravelling the molecular evolution of plantmicrobiome interactions in drylands

how plants evolved to shape their microbiota is a longstanding question in ecology and evolution i posit that the microbiome forms a crucial part of how plants adapt to changing environments and that this microbiota optimization should be manifested in a strong genomic and phenotypic signature of adaptation i propose to use natural plant variation and biogeography to dissect how plants evolved along with their microbiota to cope with aridity eight withingenus pairs of brassicaceae species have been identified distributed vicariously across a steep precipitation gradient these species pairs represent eight independent instances of adaptation to aridity this natural distribution offers an excellent framework for studying the evolution of plantmicrobe interactions under arid conditions my team will carry out an ecoevolutionary common garden experiment to compare the microbiomes of all 16 of these species under drought stress by combining this experimental design with microbiome deconstruction and gene deletion experiments my lab will i test the hypothesis that microbiallyinduced drought resistance in plants is an evolutionary trait encoded in plant genomes ii identify the mechanisms that bacteria employ to protect plants from drought and desert plants employ to attract beneficial bacteria the sessility of plants dictates a particularly strong need for microbiota optimization in order to respond to a dynamic environment when there is no option to flee microbes are known to protect plants from drought stress and plants are known to enrich particular microbes when stressed but how these processes are linked remains unknown this proposal is designed to establish this link by using our extensive knowledge on plant distribution to guide the study of the plant microbiome successful implementation will establish if and to what extent plants evolved to supplement their own genomes with those of their microbiota to cope with challenging environments
industrialising esmr to supply the next shipping fuels

the basis of our innovation is to pilot a novel approach to producing methanol never before piloted beyond our project partners lab scale prototype where we use an electrically heated stream methane reformer esmr instead of present firing of natural gas in the fired reformer used in conventional methanol synthesis the scientific background of the innovation is solid we have a successful lab prototype and many publications describing parts of the work in journals including science the esmr technology can allow very compact reactor designs up to 100 times smaller than current smr plants which combined with higher energy efficiency and no directly associated co2 emission makes the esmr reactor extremely commercially attractive for synthesis gas production the technology is also well suited to add additional hydrogen and co2 to increase production the costefficient we target a similar cost level as biogas and scalable in addition relevance or thousands of biogas sites we can scale through adding hydrogen and co2 solution can be built as a realistic alternative to fossil methanol production in the project topsoe delivers the process plant to gasnor both a biogas owner and norways largest provider of lng that in turn want to market sustainable ship fuels we have a first customer in the project that are currently building two feeder container vessels running on methanol one of europes leading ship owners wilhelmsen participating through their sustainable shipping unit topeka with the assistance on leading research groups covering both optimizing resource streams ntnu and ecosystem simulations certh we develop a comprehensive plan to pathways of bringing esmrbased plant designs to efficient and widespread use in europa
polistability comprehensive assessment of stability in pollination communities

species and ecological interactions are disappearing at alarming rates with unknown effects on key ecosystem functions basic for human well being as pollination project polis comprehensive assessment of stability in pollination communities aims to combine the forces of an expert in the study of stability in complex networks researcher and a world leader on pollination services supervisor to address one of the most relevant problems in ecology nowadays how plantpollinator communities respond to environmental changes by bridging the classical divide between the empirical and theoretical frameworks to study ecological stability and using as case study detailed data on 12 communities in the doana natural reserve southern spain across a gradient of landscape fragmentation monitored over seven years this project put forwards solutions to comprehensively quantify the response of pollination communities to environmental perturbations and elucidates the mechanisms by which pollination communities withstand global change pressures and achieve different axes of stability the novelty and high transferability of the methodology in addition to the relevance of the question make of this project an unique opportunity to advance in the prediction of how pollination communities will respond to a changing world
organocatalytic enantioselective dearomative photocycloadditions for the synthesis of polycyclic heterocycles

the photostereo action provides a general synthetic platform for the organocatalytic enantioselective dearomatization of heteroaromatic compounds by means of 22 photocycloadditions to obtain complex saturated polycyclic compounds in one step under mild conditions the proposed strategy relies on the direct excitation by means of visible light of organocatalytic heteroaromatic intermediates to access their excited state reactivity furthermore the implementation of this methodology into a flow system will enable the collaboration of the host institution with an industrial partner offering to the fellow a valuable experience of the dynamics in industrial rd photostereo will merge the expertise of the group of prof dellamico in photoredox catalysis with the expertise of the fellow in asymmetric organocatalysis overall this project promotes the efficient use of sustainable resources such as light and inexpensive heterocyclic feedstocks while bringing innovation into the fields of synthetic organic chemistry and medicinal chemistry this project will ultimately contribute to the eus scientific excellence and at long term to scientific innovation with a positive impact in the society and eus economy importantly all the competences acquired during the realization of this fellowship together with the creation of new connections with industry and academy will allow the fellow to reach a position of complete professional maturity while providing her with fruitful opportunities for gaining a permanent position as senior scientist in both academic or industrial settings
fluid texts and scholars digests reproduction of law in medieval ireland

flexi investigates how the fluid multifarious law texts were reproduced and accepted as sources of law in medieval europe using four sets of late medieval irish law texts called the digests as its main object of study the digests contain texts quoted from diverse sources and organise them into a systematic review of the legal tradition they represent the law in operation in the form of highly variegated and complex intertextual networks and therefore are an ideal sample for studying the dynamics between fluidity and unity in medieval law texts flexi focuses on how law texts were reproduced studied and transmitted in medieval ireland it is not only the first indepth study of the irish digests but also a groundbreaking attempt to synthesise philology comparative legal history network theories and digital techniques to revolutionise the research of medieval law textsflexi traces and measures the sources used in these digests quantitatively using linked data model and network analysis to reveal their compilatory principles and text reuse patterns this is an innovative approach to probe the intellectual universe of the jurists it evaluates the variation within the digests and examines the interpretative techniques by which the jurists justified and harmonised the variation flexi also looks for possible influences from other legal traditions such as the canon law and the civil law on the compilatory principles of the digests and makes comparison with medieval welsh law on how inherited materials were treated and updated in ireland and wales finally flexi tests and develops software for automated detection of parallel texts text reuse for early irish texts the toolkit and software developed by flexi will offer a longneeded digital solution to the processing of early irish texts because it can quickly identify similar texts from the vast corpus of irish materials thus revealing intertextual relationships hidden from the human eye
optimization demonstration of natural biodegradable packaging from wood in desired shapes for various industries

every year over 400 million tonnes of plastic waste is produced globally of which plastic packaging waste accounts for about 46this waste accumulates in waste dumps landfills and ends up in oceans and water bodies causing alarming threats to ecosystems this calls for sustainable alternatives for plastic usage worldwideraiku has developed a proprietary cleantech manufacturing technology for the creation of novel green packaging alternatives to bubble wrap for the packaging industry the process utilizes one raw material wood with zero chemicals and compostable end of life raikus novel material needs 10 times less wood than papercarton industry decelerating deforestation drastically even more energy and water and making it a high valueadded productraiku is poised to generate the needed disruption in the packaging market enabling manufacturers to transition to a circular economy paradigm and contributing towards eu and un green goals
coordination of the european research community on nuclear materials for energy innovation

connectnm is a cofunded european partnership on nuclear materials for all reactor generations that applies modern digital technologies to materials science practices for the acceleration of innovation it implements plans elaborated in the orientnm csa with 5 strategic goals 1 nuclear materials nm acceleration platforms 2 nm testbeds for accelerated qualification 3 intelligent materials health monitoring 4 advanced methodologies for prediction of materials behaviour in operation 5 nm knowledge organisation system accordingly the work will be organised in 5 research lines 1 advanced materials development manufacturing 2 materials component qualification testing standardization design rules 3 nondestructive examination materials health monitoring 4 advanced materials modelling and characterization 5 nuclear materials knowledge data management each research line will coordinate callselected projects connectnm will centralize transversal activities for the benefit of all projects eg coordination management et and infrastructure access communication dissemination result exploitation interaction with stakeholders data management collaboration is foreseen with international organisations and bodies dealing with safety standardisation data management as well as with fusion nonnuclear energy communities all activities align with national and european initiatives on nuclear materials strengthening rdi and avoiding fragmentation and duplication with direct involvement of industry tsos and regulatorsas active partners and endusers
in silico modeling of multidomain proteins in biological condensates

neurodegenerative disorders are one of the leading causes of disabilities and death in elderly populations worldwide to this date no established treatment can either prevent or slow down the progression of these diseases their occurrences and progression are strongly correlated with insoluble biological condensates composed of nucleic acids and proteins where the latter are multidomain proteins with both folded and disordered domains the formation and the existence of biological condensates can be described through a combination of density eg liquidliquid phase separation and network percolation transitions these phase transitions are highly contextdependent ph temperature etc and compositiondependent ie the presence of other biopolymers where these system variations can either enhance or suppress transitions or have a profound effect on the material properties of condensates formed currently we lack computational approaches that can account for such system variations and predict the phase behavior of biological condensates in this project i will develop for the first time a quantitative computational model that will enable scanning a large chemical space as well as be temperaturesensitive next i will use this model to identify the role of folded and disordered domains in the formation of condensates for two protein families related to amyotrophic lateral sclerosis frontotemporal dementia and autism spectrum disorder through largescale molecular dynamics simulations lastly i will deliver a microscopic understanding of how certain system variations are linked to neurodegenerative diseases eg ph the presence of other biopolymers and changes in protein sequence affect the properties of biological condensates i will carry out this project in the research group of prof kresten lindorfflarsen at the university of copenhagen ucph
exploring life narratives of violence among refugees from africas great lakes region aglr

this project aims to map and examine to what extent and under what conditions the life narratives of the africa great lakes region aglr refugees evolve travel and transform across time and space it will explore how these narratives shape relationships among refugees and communities in countries of transition and destination it examines how life narratives change as the aglr refugees encounter preconceived notions about themselves and their communities in host countries the study will rely on innovative methodological approaches that will include multispatial and multitemporal oral narratives developed via an african orature and artsinspired approach respondents will include refugees from aglr in both the global north and global south the project will produce new theoretical and methodological knowledge combining memory studies and migration studies this approach is designed to overcome limitations in global scholarship on the neglected narratives of millions of aglr refugees who continue to move through the global north and south due to insecurity in their home countries through both academic outputs and those aimed at a general audience tmss studys findings will challenge policymakers to think differently when designing programs geared towards refugees insights gained from studying these narratives will inspire new community visions and projects that shape relationships between refugees and their host societies in countries of transition and destination life narratives of refugees have been an object of scholarly and policy studies before but existing literature fails to engage with the subjective experiences of refugees as they navigate global contexts
enhancing the power conversion efficiency of monocrystalline nitrogendoped silicon solar cells

silicon solar cells are the most commercialized photovoltaic devices due to their highpower conversion efficiencies pce over the different types of silicon substrates for solar cells monocrystalline silicon is the one with the highest pce reported monocrystalline silicon is commonly grown by the czochralski method a process in which a small seed crystal is dipped into a melt in a crucible pulling the seed upwards to obtain a single crystal nonetheless by the same process two types of intrinsic defects can be incorporated additional atoms interstitials or missing atoms vacancies additionally the crucible used is generally silica so the result is an oxygen contaminated ingot oxygen tends to react with vacancies seriously affecting the pce of the synthesized solar cellsnitrogen has long been known to simultaneously suppress interstitial and vacancy related defects the higher the nitrogen concentration the lower the defect size which is highly favourable for defect annealing besides strongly enhances oxygen precipitation unfortunately quantitative data on the chemical and physical properties of nitrogen in silicon are rare so the mechanism through which it reacts with intrinsic defects and oxygen is still relatively unknown in consequence it is not possible to know what variables should be modified to improve the quality of the crystalthe main idea of this project is to investigate the effect mechanism of nitrogen on grownin oxygen precipitates a complete understanding would lead us to find the ideal conditions to dope silicon with nitrogen in order to reduce defect sizes and the oxygen amount to a minimum so as to reach the maximum pce in a monocrystalline silicon solar cell