Dragon09/odtu_chatbot huggingface dataset:
montenegrin center for underwater sensor networks

underwater sensor networks usns are becoming increasingly popular due to their advanced capabilities in oceanographic data collection pollution monitoring exploration of natural undersea resources disaster prevention assisted navigation and tactical surveillance applications the monusen project will increase research and innovation capabilities of the university of montenegro uom via links with the internationally leading eu research institutions university of zagreb unizg newcastle university unew and national research council of italy cnr the project will reduce the gaps and deficiencies between the uom and its eu research counterparts and improve staff research profiles in the usn field it will strive for scientific excellence based on the transfer of knowledge and expertise improved creativity strong partnerships with the leading research institutions and industry and improved research management and administration at the uomthese objectives will be reached through a set of strategic measures staff exchanges and expert visits for providing knowledge transfer onsite trainings for providing handson experience joint research actions research and innovation management trainings organization of researchindustry workshops for strengthening links to marine robotics industry joint organization of hackathons on topics dictated by industry needs within the scope of the joint research actions and joint organization of summer schools with strong emphasis on strengthening links to usn endusers from marine biology marine archaeology oceanography marine security etc
spacetime visualization of photoexcited carrier dynamics in ferroelectric solarenergy converters by ultrafast electron microscopy

giant bulk photovoltaic effect in noncentrosymmetric ferroelectric materials is currently gaining tremendous research interest due to its abovebandgap photovoltage and the observed output voltage is around 34 orders of magnitude higher than the sisolar cells hence the ferroelectric photovoltaic response is considered the nextgeneration photovoltaic device however researchers currently lack a profound understanding of the exact mechanism of the bulk photovoltaic effect and the proposed mechanisms are contradictory to each other this in turn restricts the progress of the field towards efficient solar cells the difficult part of finding the exact mechanism is due to ultrafast carrier dynamics and atomic relaxation times are of the order of 01 to 10 femtoseconds which made it experimentally inaccessible at present the excellent infrastructure and facilities of my host institute dealing with the ultrafast carrier dynamics can record the meticulous dynamics in spacetime resolution and hence can provide the exact mechanism towards the above bandgap photovoltage in the ferroelectric system therefore through this project we are going to investigate the origin of the anomalous bulk photovoltaic effect in perovskite ferroelectric oxides by filming the ultrafast photoabsorption and subsequent photoexcited carrier relaxation dynamics with femtosecond time resolution and nanometre spatial resolution using laserdriven electron microscopy in contrast to the spectroscopic approach ultrafast electron pulses in a femtosecond electron microscope or diffraction apparatus can provide nanometre spatial and femtosecond temporal resolutions at the same time and hence can provide a movie of evolving electromagnetic field in space and time based on the data generated a comprehensive physical mechanism will be put forth which will act as guidance for the selection and design of future ferroelectric systems for an improved photovoltaic response
ab initio prediction of material synthesis

ab initio simulation techniques have evolved to the point that we can reliably predict many properties of materials before they have been synthesized this paradigmatic change has led to databases that contain millions of theoretically predicted materials with desirable attributes however all this information is of little use if we cannot predict if these novel materials can be made at all i will develop a framework based on firstprinciples computer simulations to predict if and how a material can be made the proposed approach will boost the success rate of materials by design expedite experiments to create novel materials and thus greatly enhance the speed of materials discovery to achieve this goal computational methods that combine crystal structure prediction advanced statistical sampling and stateofthe art machine learning techniques will be designed the whole framework will be benchmarked on model systems with known properties the resulting software will be made generic and opensource the computational framework will be used to gain mechanistic insight into the physical processes that control the formation of specific functional materials including highpressure phases of matter perovskites and molecular crystals
mechanoregulation of alternative splicing a multiomics and single cell approach to improved cardiac function

to adapt cardiac function in response to mechanical load a network of splice factors concertedly regulates multiple target mrnas that affect biomechanics electrical activity metabolism signaling and growth it includes the splice regulator rbm20 with mutations causing severe cardiomyopathy as well as its substrate titin whose 350 exons are differentially joined to adjust the elastic properties of the sarcomere and thus ventricular filling in the spliceosome diverse rnas and rna binding proteins interact in macromolecular complexes but how their activity is regulated to adapt cardiac isoform expression and sarcomere mechanics has remained elusivewe have adapted localization proteomics to study macromolecular complexes in vivo at physiological expression levels which has previously not been possible our titinbioid knockin mice have provided the first census of the sarcomeric proteome and uncovered a previously unknown connection between sarcomeric mechanotransduction and mrna processing in the nucleus this unexpected link is the basis of our hypothesis that altered strain of the titin filament is communicated to the nucleus where the spliceosome adapts titin isoform expression to adjust sarcomere elasticity this proposed regulatory feedback loop would elegantly resolve the question of how sarcomeres adapt to mechanical loadhere we will explore how the mechanoregulation of cardiac splicing contributes to heart disease in a functional multiomics approach and develop technologies that combine single cell isoform sequencing and mechanics to examine how heterogeneity of the mechanical microenvironment determines isoform expression in the individual cardiomyocytethe overall scientific goal of the proposed work is to investigate the functional interaction of two macromolecular machines the sarcomere and the spliceosome and to evaluate mechanotransduction as a potential therapeutic target in heart failure with increased ventricular stiffness
combinatorial neuromodulation of internal states

being sleepy hungry afraid or happy impacts our daily experience and defines our behavior and actions such internal states are characterized by unique signatures of activity across neural circuits and are actively shaped by neuromodulators such as dopamine serotonin acetylcholine and norepinephrine that are released widely throughout the brain to alter the function of target neural circuits at any moment distinct combinations of neuromodulators are being released in each brain region changes in the neuromodulator balance have a powerful impact on the brainwide configurations that underlie internal and behavioral states while most mood disorders are associated with neuromodulator imbalance and most therapeutic strategies attempt to restore this balance however how combinations of neuromodulators define distinct brain configurations and shape internal states remains unknown the prefrontal cortex and the hippocampus are two interconnected regions which are essential for cognitive processing and memory they receive converging neuromodulatory inputs and synaptic alterations in these regions are critical for learning while dysfunction of this pathway is involved in most mood disorders despite the vital role of these circuits for brain function little is known about how combinatorial neuromodulation regulates circuit configuration and coordinates information flow between these regions in this project we will combine neuromodulator monitoring with largescale in vivo electrophysiology optogenetics and in vivo genome editing to answer the following questions and resolve the contribution of neuromodulators to the organization of neuronal ensembles and information gating in the hippocampusprefrontal circuit in behaving mice1 what is the neuromodulatory landscape across behavioral states2 how does statespecific neuromodulation sculpt neuronal dynamics3 what are the circuit elements underlying combinatorial neuromodulatory action
computational study of onsurface catalysis induced by ligh

on surface synthesis is an emerging field that aims to adapt traditional organic chemistry reactions to the fabrication of atomically precise lowdimensional nanostructures this has been made possible thanks to the catalytic properties of surfaces and their 2d confinement despite the rapid development of this field there are still key fundamental aspects that require additional efforts one of the main problems is the strong interaction of nanostructures with the catalytic metal surface that results in a real impeachment for applications due to the difficulty of decoupling the nanostructures from the surface to solve this the community and the host group have turned its attention to the use of photoreactions on an insulator for the formation of these nanostructures and lowdimensional materials without the use of thermal catalyzed processes on a metal surfacethe scientific objective of this fellowship is to develop computational tools to rationalize and finally predict possible photochemical reaction pathways of organic molecules deposited on surfaces in particular we have three main objectives create a virtual screening method for the study of molecular selfassembly on surface study the effect of surface substituent and selfassembly in the absorption spectrum of the molecule and a computational study of the photo reaction that can takes places on the surface for these objectives we will take advantage of the computational tools developed during the phd and postdoc of the applicant for others fields like biochemistry and wet chemistry and apply them and develop new ones for the field of onsurface photochemistry together with the hostgroup this synergistic approach together with the experience and facilities of the host and collaborators will lead to the successful completion of the project and to the strengthening the career development of the researcher
exploring transnational challenges climate change migration and energy insecurity in the mediterranean

transnational challenges are pressing issues in any region they transcend national borders and defy unilateral remedies multilateral efforts and capacity building remain fragmented regional efforts rarely bear fruit as a result despite twodecades of effort transnational challenges cannot be understood and responded effectively there has already been a growing call to rethink the existing approaches arguing for the need to understand the nature and scope of transnational challenges better why the existing approaches and frameworks for cooperation collaboration and coordination do not work and how they can be responded transnational challenges hit the mediterranean particularly hard unilateral multilateral and regional responses to them in the region remain fragmented and ineffective trachmed is a research and staff exchange programme intended to contribute to the global regional and national efforts of understanding and responding transnational challenges by conducting research in mediterranean on three such issues climate change migration and forced displacement and energy insecurity it brings together an international intersectoral and interdisciplinary research team to 1 collect interpret and process original empirical data on selected transnational challenges with a transnational perspective 2 engage with the existing conceptual and theoretical debates and contribute to the conceptual and methodological approaches for studying comprehending and responding to transnational challenges 3 develop and sustain a transnational network of researchers practitioners and institutions in the mediterranean thus increase the research capacity and shared knowledge and cooperation 4 update scientific knowledge on these issues for relevant eu policies political and economic actors interested or already working in the region and to inform international organizations and decisionmakers in the region
rohs compliant high luminescence heterostructure nanocrystals for near infrared leds and bioimaging

colloidal nanocrystals ncs that absorb and emit in the nearinfrared nir region are of paramount importance in the field of optoelectronics leds lasers solar cells telecommunication and biological imaging however most of the nir emitting ncs are based on heavy metals pb cd hg which are highly toxic and are restricted from widespread use by the european regularity concerns therefore the development of nir emitting environmentally friendly cdpbhg free ncs are of interest nirlumin proposes a strategy to develop high nir 1135um luminescent stable ainte2gain2s3znsse coreshellshell css nc heterostructures with controlled bandgap and size in which the outer shells will protect the surface of the core and enhance the photoluminescence quantum yield by passivating the dangling bonds and surface traps while the intermediate layer will stop diffusion to prevent the undesirable bandgap enhancement further the advantages of these ncs will be directly translated into device performance in the led for biological imaging these nanostructures will be overcoated with a ceramictype alumina shell and transferred to the aqueous phase the whole work will be conducted in five major steps i synthesis of css ncs characterization and study of their structural and photophysical properties ii surface functionalization to investigate the surface ligand chemistry on their optical and electrical properties and to make the ncs compatible for devices and bioapplication iii cytotoxicity study and bioimaging using the alumina coated ncs iv optoelectronic characterization to understand the optical and electronic characteristics of the ncs on film finally v fabrication of led using these ncs as an active layer and optimization to achieve an efficient nir emission
nomad management of urban development the complex value of temporary communities

empty and vacant spaces constitute a significant waste of resources in european cities at the same time ways of inhabiting cities are changing and becoming more flexible in this context urban nomads are people who experiment with temporary ways of living and working inhabit places for a short period of time and eventually have to movethe research nomad nomad management of urban development the value of temporary communities intends to explore and operationalise the urban values produced by temporary usescurrently local communities wellbeing is increasingly promoted by european policies and the new european bauhaus temporary uses are realized by different kinds of urban communities in urban regeneration processesbut although they generate urban values the values they produce for urban development are still not evidentthe main objectives of the research are to identify the urban values of temporary communities and to boost temporary reuse practices through a valuedriven approachfor this purpose nomad will focus on the significant experience of two pioneer cases stad in de maak in rotterdam and communa in brusselsthe research will follow a crossdisciplinary approach to get the nomadic urban values nuv generated by the temporary uses by changing the urban atmosphere and the urban ecosystem services the field research and workshops will be conducted in a van both for the field research and for the disseminationthe research will consist of two phases the first phase includes the nuv monitor and map collecting peoples perceptions sounds images and statistical information that will be analysed and collected in multimedia mapsthe second phase of the research will involve the nomad catalogue and platform collecting nomadic practices in a catalogue of temporary reuse alternatives and a platform with multimedia maps and results to facilitate different stakeholders in temporary use planning
interactionseeds

interactionseeds partners have joined forces to facilitate and connect different worlds industry citizens arts through the development of a repository of 50 locally proven and easy to replicate interaction schemes the repository wp1 expected to turn into a platform at exploitation stage will ultimately take the form of a twosided platform connecting a network of stakeholders providers of societal and cultural interaction schemes that have proven their value and that have a potential for replicability beyond their geographic range organisations having missions in fostering connections between industry society and art willing to explore adapt and test locally proven interaction schemesduring the project 20 test cases of interaction schemes will be implemented wp4 to support ri knowledge valorisation these test cases will notably involve ri stakeholders previously engaged and trained thanks to the development of a training kit wp2 protocol for the test cases implemented will be designed and adapted to the local context in wp3 finally a set of recommendations wp4 on why and how to facilitate the implementation of new test cases these recommendations will be largely disseminated to 100 ri representative stakeholders such as clusters edih incubators etc to support the projects replicability and large use of the repository
a theory of memory causation

on the causal theory of memory remembering an event requires a causal connection to a past experience i can remember my last birthday because i have experienced it before on the simulation theory in contrast remembering a past event is very much like imagining a future one in both cases a causal connection to a firsthand experience of the event is not necessary the debate between causalists and simulationists has been at center stage in the thriving new field of philosophy of memory despite this there has been no systematic analysis of the notion of causation relevant to memory as a result the nature of memory causation has remained largely unexploredthis project aims to fill this significant lacuna it will develop the first comprehensive theory of memory causation bringing together results from the philosophy of causation and the interdisciplinary study of memory it will aim to clarify what it means to say that memories are caused by past experiences and to establish whether such causation is necessary the projects core thesis is that claims about memory causation should be relativized to causal models mathematical models that represent the functional relationships between variables in a system a memory is caused by a past experience iff relative to an appropriate model of the memory system it is counterfactually dependent on it but only in precisely defined contexts if all memories are so dependent then causation is necessary for remembering with a proper formulation the causal necessity thesis can be assessed the working hypothesis is that the thesis faces substantial difficulties and is likely false hence causal theories fail and the simulationist rejection of the necessity of appropriate causation is warranted the project will make an innovative and muchneeded contribution to the central debate of contemporary philosophy of memory helping us understand what memory is
mucosal breaks of bacteria trigger pathogenic bcell responses in ancaassociated vasculitis

ancaassociated vasculitis aav is a rare and severe autoimmune disease characterized by inflammation of the small blood vessels ancas autoantibodies against proteinase3 pr3 or myeloperoxidase mpo play a central role in the pathogenesis they induce excessive activation of neutrophils resulting in necrotizing injury of small vessels the loss of tolerance in aav is thought to be the result of genetic environmental and ageing factors although infectious triggers are implicated their exact role in the pathogenesis of aav remains unclear previous studies demonstrated that aav patients with chronic nasal carriage of staphylococcus aureus or corynebacterium tuberculostearicum exhibited a higher relapse rate and eradication treatment reduced relapses we hypothesize that pathogenic sinonasal mucosal breaks of bacteria activate autoreactive bcells through molecular mimicry resulting in autoimmune responses that mediate aav this proposal is to investigate the role of sinonasal mucosal breaks in aav through repertoire sequencing of peripheral blood and tissue bcells of aav patients combined with 16s sequencing of the sinonasal bacterial microbiome subsequently representative monoclonal antibodies will be expressed and reactivity towards ancas and sinonasal bacterial antigens investigated lastly the findings will be validated by studying serum antibody reactivity in large cohorts of aav patients success of the proposed studies would transform our understanding of the autoimmune responses in aav and potentially elucidate a mechanistic role for sinonasal mucosal breaks of bacteria in triggering disease initiation and progression further success could lead to novel therapeutic approaches focused on preventing mucosal breaks andor clearance of pathogenic strains through this fellowship i hope to develop myself into an independent reseacher expert of aav and obtain a position as future academic clinician and principal investigator
deep genetics to study and uncover hidden biology

human genes are organized in complex networks to produce thousands of proteins to perform a myriad of functions whereas we have detailed maps for most biochemical pathways the wiring of genetic networks in human cells is poorly understooddevelopment of powerful human genetic tools crispr rnai haploid cells to which i made crucial contributions have proven invaluable to study genetic networks however they face two major limitations first they provide information at the gene level whereas it will be much more informative to understand genetic regulation at the level of protein domains or individual amino acids second important biology can be masked for example by the cell state or interfering activity of other geneswith deepgenetics we will bring our understanding of the genetic regulation of cellular phenotypes to the next level and mine hidden biology that even impacts on wellstudied cellular traits we will i counterbalance the use of lossoffunction and gainoffunction genetics to obtain a solid genelevel inventory on the regulation of cellular phenotypes ii identify genes that mask unknown biology and use modifier screens to expose and define these processes as we have recently exemplified in my group leading to the discovery of important new cellular pathways and iii connect phenotypes to the functional protein domains and ultimately to the amino acid level thus deepgenetics will provide precise views on the regulation of key cellular phenotypes at the amino acid level and will cross the boundaries of our knowledge by exposing hidden biology