Dragon09/odtu_chatbot huggingface dataset:
selfpowered conductimeter for digitalization of rapid molecular diagnostics

despite huge progress in prevention and treatment over the past century infectious diseases still impose a great health burden for this reason labcentralised immunoassays and nucleic acid tests that allow for specific pathogen identification with limits of detection reaching few copies per ml of sample are readily available and supported by both national and private health systems in the developed world however these tests are neither affordable nor accessible to patients in low and mediumincome countries fortunately lateral flow antigenbased have proven to be a fast reliable and affordable tool to detect a wide range of pathogens however such tests suffer from crossreactivity with related bacterial or viral species and more importantly they often require 105 pathogens per ml to yield a positive result it becomes clear that there is a clinical and technological need to develop rapid tests that combines pcr sensitivity able to detect one copy per ml with lf affordability pronto proposes a novel low cost sustainable and selfpowered readout system for nucleic acid detection based on conductimetry the key component consists on a paperbased and single use selfpowered conductimetric sensor developed during erc consolidator grant supercell the sensing approach is unique and minimalistic as it breaks the classic paradigm sensorelectronicsbattery as the sensor and the power source are merged into one element while making the detection system energetically autonomous the simplicity of the approach will enable the deployment of highly sensitive and digital tests for infectious diseases at affordable prices and in a sustainable manner at a global scale
the fundamentals of cardiovascular calcification from cells to therapy

with this project i propose to identify fundamental mechanisms of cardiovascular calcification cvc and new therapeutic targets using zebrafish as a model systemcvc characterised by progressive calcification of the soft tissue causing impaired blood circulation is a frequent form of cardiovascular disease because the pathophysiology of cvc is highly heterogeneous the exact cell types and signalling pathways triggering tissue calcification are still unknown thus limiting therapy options most studies on cvc rely on in vitro systems which fail to reproduce the multicellular environment or mammalian in vivo models limited for liveimaging and highthroughput analyses by combining my expertise in cardiovascular research and bone biology i propose to use zebrafish as a model to elucidate the multifactorial mechanisms of cvc focusing on different developmental stages and cardiovascular tissues in aim 1 i will use a broad array of zebrafish genetic models to characterise the cellular dynamics molecular mechanisms and functional impact of cvc in vivo i will also study the role of specific cell populations present in regenerating valves and human valve implants with cvc in aim 2 i propose to identify new local and systemic therapeutic strategies to blockreverse cvc taking advantage of the zebrafish amenability for genetic manipulation and highthroughput screening i will recruit bonedegrading cells to the cvc site and determine their potential to reverse tissue calcification moreover i will select a short list of small molecules identified in a largescale screen in zebrafish and will test their therapeutic potential in cardiovascular cells derived from hipscs of cvc patientsaltogether with this interdisciplinary approach i expect to bring a new perspective on the mechanisms and therapeutic targets to blockreverse cvc which could have a considerable impact on the european population severely affected by these diseases
understanding and improving choices investigating the role of stressrelated neuromodulators and psychiatric diagnoses in decisionmaking and precommitment

everyday decisions such as deciding what to eat or whether to exercise have a profound effect on our longterm health both stress and a diagnosis of certain psychiatric disorders are two factors which can impact these decisions often resulting in detrimental health outcomes betterchoices will investigate the biological mechanisms of this altered decision making and test the effectiveness of a behavioural strategy which aims to improve decision making in study 1 i will investigate how pharmacological increases in two key stress related neuromodulators cortisol and noradrenaline affect participants willingness to exert effort to obtain rewards ro1 additionally i will test whether precommitment can buffer the detrimental effects of increases in cortisol and noradrenaline action on effortbased decisions ro2 precommitment involves preemptively restricting ones future choice set to improve decision making yet we do not know how or if people use this strategy under stress or in psychiatric disorders in study 2 i will develop a novel task the precommittoeat paradigm to precisely quantify the individual effectiveness of precommitment when participants make food choices ro3 this paradigm will then be used to test the effectiveness of precommitment in patients with a diagnosis of depression or schizophrenia during a nonacademic placement in a psychiatric clinic during the nonacademic placement i will also implement a psychoeducation program to help patients make better health decisions using behavioural strategies such as precommitment by using an interdisciplinary approach and combining methodologies from psychopharmacology and behavioural economics betterchoices will provide novel insights into how we make decisions under stress the project will also help to improve everyday decision making both in healthy participants and in psychiatric disorders thereby promoting better health outcomes
closedloop and multisensing delivery tool for controlled laser ablation of tumors

the need of a minimally invasive alternative to traditional cancer surgery is pushing the global market of thermal ablation devices mainly for treating delicate organs brain prostate breast pancreas lung in inoperable patients with its fine and flexible applicator laser ablation la was successfully used in lesions difficult to access with conventional surgery and its market is expected to show the highest growth rates in the next 5 years however crucial aspects and clinical needs are still unsolved for la the poor reproducibility of the procedure outcome and the lack of miniinvasive and accurate intraprocedural control make la strongly relying on the doctor experience the lack of control causes subtotal tumor coverage thus bringing cancer progression and recurrence to solve this issue in the erc laser optimal project that i lead it was developed the first platform which integrates a closedloop control strategy of la with multiplexed fiber optic sensors foss at the millimetricscale and modulates the laser power based on the measured tissue temperature leila is the integration of this control platform with a novel smart applicator embedding the laser delivery and the temperature monitoring with foss in this poc proposal the technicalcommercial feasibility study will be performed to move the leila system to the market the poc will allow prototyping the system establishing contact with stakeholders for testing and integration of leila in existing medical systems and preparing a readytouse tool the poc will also set the market and health technology assessment the business model and the ip protection strategy with identification of the best exploitation strategy for valorising the knowhow
bio inspired geotechnical applications to launch paneuropean solutions

bigalps aims at creating a market breakthrough in the soil stabilization field by offering a unique biotechnology for soil treatment a complete environmentally friendly solution with the capacity to treat some of the most critical soil stability problems related to current societal challenges landslides erosion foundation soil stabilization etc biocementation is an innovative natureinspired soil improvement technique based on the metabolic activity of microorganisms to produce calcium carbonate that binds the soil particles together the technology has the potential to substitute energyintensive and polluting soil improvement methods currently available that are hazardous to the natural environment thereby contributing to climate change mitigation and adaptation the project builds up on two previous erc projects advanced erc and proof of concept that allowed among others the development of three patents bigalps is the natural continuation of previous accomplishments and will further mature and validate the biocementation technology to achieve full compatibility with real environment existing norms and industry standards while explore the most efficient business model the work will address two interconnected objectives 1 mature and validate the biocementation technology in solving real engineering problems related to current society needs landslides erosion and foundation soil stabilization and 2 achieve the market uptake as an alternative to traditional cementbased soil improvement techniques three pilot sites will be used to mature and demonstrate the technology in real environment as well as to introduce the technology in specific markets of europe with direct feedback and help from main players of the industry the goal is to have a marketready solution which will be investment ready and derisked to ultimately create a market breakthrough and grow into the next big thing in geotechnical and geoenvironmental engineering
the shrinking stock market investibility and creative destruction

there are ever fewer listed firms in the us and europe and listed firms produce an ever shrinking share of innovation over the past 25 years the number of firms listed on a stock exchange has dropped by 41 in the us and 55 in europe at the same time listed firms account for a shrinking share of the highly disruptive inventions that have the most potential to boost productivity and growth in the us for example listed firms account for only 8 of the most groundbreaking patents today down from a peak of 34 in 1969 these two mega trends combine to make an ever increasing share of innovation uninvestible for most individuals who owing to investorprotection rules are barred from investing in unlisted firms the objective of my project is to study the economic consequences of this increasing wedge in access to the financial rewards of breakthroughs in science and technology between the few and the many disruptive innovation creates winners and losers workers and savers can in principle hedge against the risk of losing their jobs or savings due to creative destruction by investing in the winners whether everyone or only the few can hedge depends on the extent to which disruptive innovation is publicly investible i will measure the investibility of disruptive innovation over the period 1841 to today taking into account that a disruptive innovation that is born private can become publicly investible as its creator goes public is acquired by a listed firm or sells the patent to a listed firm armed with this measure of riskspanning i will investigate how the economywide cost of capital is affected when limited investibility results in an unequal sharing of the benefits of disruptive innovation between the wealthy and the many finally i will test if differential access to highexpectedreturn investment opportunities as more and more economic activity takes place in private markets can help explain the rise in wealth inequality
music processing for cochlear implants based on auditory and neural modelling

cochlear implants cis have been tremendously successful in restoring speech communication for deaf people however the enjoyment of music through cis is still quite limited the objective of the proposed project music processing for cochlear implants based on auditory and neural modelling musician is to extract and transmit the most prominent features of music rhythm pitch timbre such that the listening effort of ci users is reduced and their music appreciation is improved to this end we propose to perform fundamental research into measuring and modelling the ci users music perception and to develop improved processing methods capable of simplifying music signals to their most essential aspects the project thus addresses the information bottleneck composed of the electrode array and its interface with the auditory nerve and will help to reduce the perceived distortions of music in ci listeners within the proposed programme two labs with extensive experience in signal processing and audiology the institute of communication acoustics at ruhruniversitt bochum beneficiary residing in bochum germany and the auditory engineering laboratory at mcmaster university associated partner residing in hamilton canada will host the experienced researcher dr anil nagathil who is a pioneer in the development of music processing methods for cis the proposed interdisciplinary project will enable dr nagathil to acquire knowledge from several scientific domains and to integrate this expertise into the methods of auditory modelling and music processing the outcome of this project has a substantial commercial impact and the potential to improve the quality of life of hundreds of thousands of ci users worldwide
transmission of the human microbiome and its impact on health

the human microbiome is a key component of our own biology and has important biomedical applications but while its composition has been studied in depth and linked with several lifestyle and disease factors it is still highly unknown how its members are acquired spread and transmitted across hosts our preliminary results suggest that persontoperson microbiome transmission mt is extensive and shapes the microbiome according to host interaction networks leading to the hypothesis that microbiomelinked diseases that are considered noncommunicable are instead partially communicable microtouch will i develop the methods needed to model mt in human populations from metagenomic sequencing ii unravel the features of microbial transmissibility and iii detail the contribution of mt to host conditions that are currently considered noncommunicable we will first empower metagenomics with the ability to track and model the transmission of known and unknown members of the microbiome and will then apply these methods to specific case studies of mt in humans children and adults and nonhuman primates across diverse family social and interaction networks metaanalysis of mt integrating publicly available datasets will unravel the factors impacting mt the most and the degree of transmissibility of each microbiome member exploiting the large and deeply phenotyped metagenomic datasets available to the pi microtouch will characterize the role of mt in shaping the connections between the gutoral microbiome and i nutrition and cardiometabolic health ii oral diseases iii cancer and cancer immunotherapy iv autism and v the westernization process microtouch will advance our understanding of the epidemiological forces shaping the human microbiome and will link mt with host conditions and risk factors thus enabling the development of biomedical strategies promoting or limiting the transmission of specific diseaseassociated microbiome components
effects of climatic extremes on ecosystem stability

ecosystems provide many key services essential for our wellbeing these services depend on the temporal stability of plant communities in turn stability depends on resistance which is the capacity of plant communities to withstand exogenous perturbations and on recovery from their impact extreme climatic events disrupt the stability of ecosystems with unpredictable consequences on ecosystem services as the intensity and frequency of climatic extremes is expected to rise understanding how ecosystems respond to extremes is an extremely urgent taskprevious studies exploring the stabilityclimatic extremes relationship suffer from different limitations i lack of insitu data on vegetation stability to conduct worldwide analyses ii scarce focus on the joint influence of taxonomic and functional diversity in affecting stability mechanisms under extreme climate moreover few investigated if extremes cause critical transitions of ecosystem functions this has prevented understanding of how different ecosystems react to climatic extremesthis project aims at addressing these limitations and improving our fragmented knowledge on the relationship between extremes and stability combining cuttingedge analytical tools with extensive and novel global databases of timeseries of insitu vegetation and climatic extremes data the project will analyse the relationship between stability and climatic anomalies and how it varies in different ecosystems results will provide worldwide predictions of ecosystemspecific resistance and recovery to climatic extremes and new approaches for anticipating critical transitions of ecosystem functions these outputs will be essential for i guiding future policies aimed at reducing the impact of extremes on society ii mitigating economic loss due to extremes in crucial sectors such as agriculture and food production iii providing new methods for investigating how climatic extremes affect ecosystem services
holography in the gravitational wave era

the revolution unleashed by the discovery of gravitational waves will gradually unfold over the coming decades the detection of a neutron star merger by ligo and virgo opened a new era in multimessenger astronomy future groundbased interferometers such as the cosmic explorer and the einstein telescope will extend the range of detection to the entire universe and the frequency to millions of detections per year spacebased missions like lisa may discover gravitational waves from phase transitions in the early universe reaping the benefits of this experimental revolution requires a theoretical understanding of quantum matter coupled to dynamical classical gravity the fact that the relevant physics is often outofequilibrium andor strongly coupled makes this a challenging regime for conventional approaches the purpose of this project is to use holography also known as gaugestring duality to make essential contributions in this direction i have recently pioneered and provided proof of concept that this line of research is both powerful and feasible in the next five years i will turn these initial investigations into a fullyfledged research program to improve our understanding of i cosmological phase transitions in particular of bubble dynamics and baryogenesis ii neutron stars with a focus on outofequilibrium physics in binary mergers iii spacetime singularities specifically in the presence of quantum matter effects these three main objectives are interconnected by two horizontal lines i identification of universal observables which hold the best potential to make contact with experiment ii communication with other fields which is crucial for the success of an interdisciplinary proposal
sustainable european sodiumion batteries for stationary applications featuring improved processes inherently safe and nontoxic materials

sodiumion batteries offer enhanced costeffectiveness and sustainability challenging the dominance of lithium batteries in the stationary energy storage sector the sprint project will gather 8 industries 2 smes and 8 academic partners incl one associated partner for 46 months to optimise and demonstrate two sustainable technoeconomically viable and safe quasisolidstate sodiumion batteries better meeting the requirements of stationary energy storage applications this will be achieved relying on abundant nontoxic safe and competitive materials available in eu supply chains brought to scale within sprint ie optimised nfp cathode materials relying on novel synthesis hardcarbon materials derived from a validated forest residues supply chain in northern europe and quasisolidstate polymer and polymer composite electrolytes with a solventfree synthesis and which are major advancements vs flammable liquid electrolytes strategic interface optimisations will be leveraged to meet endusers requirements in terms of cells cycle life sprint also aims to bring to scale dry electrode processing incl using pfasfree binders to enhance the sustainability of battery manufacturing batteries encompassing such solutions will be demonstrated on two demonstration sites in austria portfolio hybridisation balancing services and lithuania residential pv increased grid capacity for ev chargers and sprint will also engage with international usecase providers eg morrocco tunisia kenya sierra leone etc all in all it is foreseen that sprint will reduce costs 004kwhcycle enhance energy density 200whkg 420whl and power metrics 500 wkg improve cells cycle life projected 5000 cycles while ensuring safe operation leakfree technology for a high market penetration the consortium will accompany all solutions to commercialisation supported by the created exploitation board to facilitate their uptake
a revolutionary approach for maximising process water reuse and resource recovery through a smart circular and integrated solution

r3volution r3v project will revolutionize industrial water management in the eu providing key innovations that can enable economically environmentally and operationally water reclamation projects by addressing solutes and energy recovery challenges and generate significant impact for the eu in the next decadeto pave the way towards sustainable and efficient water and resource consumption r3v takes on the challenge of developing and demonstrating a resource recovery solution that will enable 90 water reuse across most intensive water industries applicable upstream and downstream whilst recovering 45 effluents solutes 50 waste heat reuse and eliminate 100 of hazardous substances r3v will investigate develop and demonstrate tailored membranebased treatment trains coupled with waste heat and a digital process assistant dpa to support the design phase to achieve optimal configuration for different industrial settings minimising risks in implementation and provide critical support in operation with the aim to demonstrate r3v solution capabilities and replicability potential across varied process industries the project includes 4 physical demo cases at pilot scale targeting several up and down streams in a variety of industries with high water discharges and complex effluents petrochemical biobased chemical pulp paper and steel each led by renowned technological partners the project will also assess the transferability of the results by evaluating one additional industry mining in chile and its replicability in 3 additional streams via the dpa tool developed within the project the consortium perfectly maps the triangle of competences required to develop r3v solution membrane technologies and design of treatment trains energy recovery and digitalisation considering also transversal competences such as economic environmental and social assessment together with the exploitation plan of the developments
the first total artificial heart tah that truly mimics the human heart and has the potential to revolutionise the market

the realheart tah system rts is the first total artificial heart designed to mimic the structure and function of the human heart its unique patented construction of two atria and two ventricles is separated by an atrioventricular plane which contains the valves enabling to pump blood naturally whilst reducing the risk of blood flow complications rts is designed to be efficient 12h battery silent lightweight 25kg easy to implant and automatically adapt to different physiological activity levels it consists of two identical artificial heart pumps a drive line and an intelligent control unit rts is connected via a cable through the skin to a controller carried together with two batteries in a belt around the waist rts is aimed as a permanent solution for endstage heart failure patients but also for patients waiting for a transplant realheart will complete glp animal trial clinical trial preparatory activities and firstinman efs trial during the eic project