Dragon09/odtu_chatbot huggingface dataset:
engineered particles for chemical communication

this project aims to the development of communication at the nanoscale and to advance in the understanding of how abiotic micronanoparticles can communicate between them and how micronanoparticles can communicate with living systems in this context an approach for establishing communication at the nanometric level is to mimic how nature communicates chemical or molecular communication based on transmitting and receiving information by means of molecules chemical messengers is one of the communication forms used by living organisms moreover many swarm systems found in nature communicate by modifying the environment using a concept called stigmergy the advantages of nanoparticles that communicate each to another are immediately obvious they constitute the basis of a dynamically interacting network eventually resulting in certain autonomy of the system if we would be able to raise the bases for communication between micronanoparticles and between micronanoparticles and cells the potential future applications in the biomedical field environmental research and industry technology are almost unlimited the project will establish firm handholds for the use of nanoparticles able to communicate from one to another and with cells in different applications the project will trace optimise and adapt all single steps from the idea to its implementation into applicable final systems with the aim of targeting issues that are difficult to address with conventional single particles the project is divided into three wps the first work package wp1 will create the basic elements for chemical communication in a more complex situation wp2 will use the tools of wp1 to develop systems able to establish communication between nanoparticles and living systems finally wp3 will generate nanosystems integrating gated nanoparticles and uptodate electronics to develop new communication structures
accelerating dc dynamic cable technology for sustainable european electricity grid

offshore wind generation is critical to realizing the european green deal and the broader eu ambition to reach climateneutrality by 2050 a third of all the offshore capacity installed could be floating since this technology unlocks wind potential in deeper waters at greater distances offshore technological trends have advanced towards highvoltage direct current hvdc as a mature solution over longdistance transmission dynamic export cables float in the water and carry power from the moving platform to the grid a key challenge is these cables need to accommodate combined electromechanicalthermal stresses no hvdc dynamic export cables currently exist and industry views this as a critical bottleneck for floating offshore wind development therefore this is a key enabling technology for secure grid integration of largescale and longdistance floating offshore wind power plantshvdc dynamic cables for floating offshore applications present unique challenges and risks from technical environmental operational and economical perspectives to address these complex interdisciplinary issues this project brings together a consortium from academic experts manufacturers users and insurance advisors the project will i validate the insulation reliability of a new dynamic hvdc export cable ii establish fundamental understanding of combined electromechanicalthermal aging mechanisms facilitating the development of test protocols that qualify and verify the integrity of hvdc dynamic cables iii identify routes for material sustainability for the cable to meet the eus circular economy ambitions and iv use the underpinning technical knowledge gained to reduce risk and build confidence for deploying the new cable technology and thus enhancing the insurability and financial viability of future floating offshore infrastructure as a result a prototype 320 kv dynamic hvdc export cable core will be designed manufactured and validated in this project
exact results from broken symmetries

symmetries serve as our main guide in studying physical phenomena the more symmetric a system is the more constrained are its degrees of freedom and the better prospects we have to understand and solve it significant progress has been achieved in the study of theories with high amounts of symmetry in the last decades supersymmetry and conformal invariance are the main reasons why the beautiful idea of holography materialised into the adscft correspondence and the discovery of hidden symmetries integrability in gauge theories was possible thanks to supersymmetry modern mathematical techniques allowed the evaluation of the otherwise unfathomable path integral and the comprehensive study of a long list of physical observables finally the successful revival of the conformal bootstrap program is based on conformal invariance these breakthroughs are unfortunately applicable only to theories with unrealistic amounts of symmetry brokensymmetries will break this impasse by applying the aforementioned ideas to more realistic theories where some of the supersymmetry andor conformal invariance are broken the key innovation of brokensymmetries is to still make use of a broken symmetry symmetries are captured by ward identities which we can still derive in various cases of symmetry breaking broken symmetries also imply powerful nonperturbative relations that observables obey we will combine these with the developments mentioned above producing novel exact results our approach will give a handle on otherwise insoluble problems the objectives of brokensymmetries are to obtain exact results while breaking1 conformal invariance spontaneously keeping supersymmetry intact2 supersymmetry explicitly keeping conformal invariance intact3 both supersymmetry and conformal invariance turning on the temperature4 supersymmetry generators in the context of integrability which get upgraded to quantum groups generators
interdisciplinary model for understanding climate change adaptation

social scientists have generally treated climate change cc vulnerability as homogeneous across social space underestimating the serious social distortions and conflicts it produces previous research conducted by the fellow suggests that cc impact is unevenly distributed even within small social units such as indian villages and fijian islands this project is guided by a hypothesis based on the fellows earlier work economic and social relations class gender ethnicity religion caste etc have an overwhelming impact on cc vulnerability and adaptation practices examining one of the regions in the world where the impact of cc is most advanced rural india the proposed project aims to generate detailed empirical data for tracing the connections between cc and existing social hierarchies under the supervision of a leading expert in modelling the result of empirical project will be turned into a generalisable model that can be used to understand and predict other agrarian societies experiences of cc and their differential modes of adaptation drawing on debates in economic sociology socioecology and environmental economics the projects empirical research will take place in two villages in maharashtra india where agriculture is in the midst of an ongoing crisis caused by biophysical processes the fellow will employ mixed methods using structured quantitative household surveys and semistructured qualitative interviews which will be collected during two visits to india the development of an evidencebased framework will be a pioneering contribution to our knowledge about the differing ways in which different members of a society are impacted by and respond to cc as such it addresses core eu objectives such as preparedness for the impact of climate change to protect lives and assets so helping confirm the eu as leading developer of knowledge solutions for the most pressing problems of humanity
giantleaps during tumorigenesis dissecting saltatory evolution in cancer in the making

tumorigenesis is an evolutionary process driven by gradual mutation acquisition to confer selective advantages to somatic cells dna rearrangements are the most common cancer driver mutation outnumbering base substitutions rearrangements amplify disrupt and fuse genes or alter their gene regulation ultimately driving adaptive changes to initiate cancer metastasis and therapy resistance cancer genomics has revealed that most of these alterations arise as complex genomic rearrangements cgrs where a multitude of changes arise in a short time while in most cases deleterious to the cell in rare cases cgrs confer an adaptive malignant phenotype in one giantleap through saltatory evolution events sees reminiscent of the hopeful monsters theorised by goldschmidt given their potential to overcome strong selective barriers it has been proposed that sees draw the line between benign lesions and lethal cancer and understanding their mechanisms is thus fundamental to tumour biology however the identity of cells undergoing sees has remained elusive with cancer genomics studies focusing typically on longestablished cancers rather than early or even initiating cancer cells intriguingly cgrs are largely explained by cascades of atypical cell nuclei ie nuclear atypias fueling rearrangement formation providing an opportunity to study seesbuilding a novel automated aidriven framework that couples imaging and singlecell multiomics we will leverage nuclear atypias as a phenotypic indicator to dissect principles and mechanisms of sees in the making and advance fundamental cancer biology using highly controllable cell lines and organoid models of colorectal cancer crc a tumour thought to be driven by sees we will unravel pathways genetic contexts and chromosomelevel constraints determining sees finally via validation in patient samples we will pave the way to determining sees in future clinical studies to advance precision oncology
integration of citizen science best practices to upscale and maximise projects impact related to green deal and eu missions

the main objective of the proj is to generate a eu wide network of connected citizen science projects a combined support program of direct funding and support services will be delivered to a group of high potential citizen science initiatives a strong set of communication dissemination and knowledge transfer will be implemented to engage all actors in the quadruple helix around the citizen science networks the project will consist of 5 work packages to be implemented for 36 months wp1 lead uam is devoted to coordinating the project in an efficient and transparent manner for the whole consortium wp2 lead sur with significant participation of uam will do a benchmarking on citizen projects to identify the barriers needs and challenges of the new era and eu missions to implement best practices on citizen science wp3 lead ut with significant participation from ulb and amu will focus on selecting and supporting the best citizen science initiatives to be upscaled to other eu regions from europe wp4 lead ulb with significant amus participation will be devoted to analyze the impact of the project and the transfer of the results to policy makers and regulators wp5 lead nkua will focus on communication dissemination sustainability and exploitation the expected results of the project are 1 tool kits training materials and methodologies about best practices on citizen science available to all stakeholders 2 network of connected citizen science initiatives sharing activities data and synergies 3 approach from cs subprojects to all actors of the quadruple helix to citizen science initiatives 4 interest by funding bodies in the cs subprojects supported 5 materials developed policy briefs or similar for the review of policies impacted the team is formed by the civis university alliance and mfn that brings to the project its expertise and networks generated thanks to its predominant role in eucitizenscience projects
green nudges for sustainable forestry and agricultural practices post 2027

behavioural and cognitive biases reduce the ability of decision makers to adopt the best solutions among the alternatives available borrowed from preexisting knowledge in psychology on priming nudges are defined as gentle interventions in a decision makers choice architecture default choice information presentation framing etc which enhance the likelihood of optimal choices forestagrigreennudges will first review initiatives and projects which explicitly or implicitly use green nudges to promote the use of sustainable practices in farming and forestry it will then assess each type of nudge according to two types of criteria 1 criteria associated with efficacy in promoting the use of the desired practices over a sufficiently long period and 2 criteria dictated by ethics and good practice principles transparency nudgee awareness participationselfregulation actorspecificity etc that guarantee the quality of the implementation process nudges will then be tested in the field and assessed on a grid reflecting the desiderata of efficacy and implementation quality the set of successful nudges will be enriched by innovative nudges based on information regarding attitudes and strategies of actors along the entire value chain the resulting set of nudges together with their corresponding implementation guidelines and the business models and market conditions which favor their application in agroforestry will be collected on an online tool inudge academy whose target audience will include policy makers wholesalers retailers farmers and foresters the tool will associate each nudge with implementation rules possible domains of application and possible risks in terms of efficacygood practice tradeoffs diffusion of the results among farming and forestry experts policy makers and actors along the value chain will maximise the impact of the project enhancing the adoption of sustainable practices in the farm and in the forest
transient inactivation of hypothalamic hormone release to prevent posttraumatic stress sensitization

stress is the foremost consequence of human life and became a pressing societal burden through the many sensory and societal pressures that have evolved during the past decades severe stress induces maladaptive changes in the brain that clinically manifest as posttraumatic stress disorder ptsd despite 4 of the population presenting ptsd only symptomatic therapies are available in the secretcells erc award we have identified a multimodal neurocircuit that induces brainwide sensitization to stress through the sequential recruitment of hypothalamic midbrain and then cortical neuronal circuits particularly we identified protein targets that can simultaneously affect hormone and neurotransmitter release within this circuit and whose knockout makes mice stress resilient therefore we used unbiased proteomics to select protein interactors that participate in the related signaling cascades determined the biochemical parameters of any such interaction and the xray structures of the relevant protein complexes moreso a highthroughput screen was established to identify inhibitors here we will apply this knowledge to use interacting proteins as templates for smallmolecule inhibitor discovery and hit optimization subsequently we will profile the pharmacology and cytotoxicity of the candidates in vitro thus we will take critical steps towards developing a circuit breaker that can inactivate the neuronal contingents that are causal to the development of ptsd thereby we will offer a fundamentally novel framework for pharmacotherapy
treasures digging into dwarf galaxies

the milky way is an environment rich with satellite galaxies stellar streams and accreted systems encoded in these structures is the formation and evolution of the galaxy through cosmic time fortunately these nearby relics can be studied in extraordinary detail star by star revealing the properties of the first stars the buildup of chemical elements in the universe the nature of dark matter and hierarchical galaxy formationto unlock these treasure troves of hidden information i designed a largescale survey 4dwarfs pi skladttir 520000 fibre hours that after a very competitive 2year selection has now been accepted as a 5year 4most survey starting in 2024 4dwarfs will collect highquality spectra of individual stars in close to 50 dwarf galaxies and dozens of stellar streams from systems currently undergoing disruptionthe goal of treasures is to execute and exploit this large 4dwarfs survey to its highest scientific potential treasures will provide the community with stellar ages radial velocities and chemical abundances for over 130000 stars and thus increase the number of stars with detailed abundance information in dwarf galaxies and streams by several orders of magnitude ensuring the farreaching impact of this project furthermore treasures will use stateoftheart models to contrast these new large data against theory and put in context with the milky way through an ambitious combination of modelling and data of unprecedented magnitude and completeness treasures will quantify and put fundamental constraints oni the properties of the first stars mass and energy distributionsii the origin of the chemical elements physics of stars supernovae and neutron star mergersiii hierarchical galaxy formation at the smallest mass scales and structure of dark matter halostreasures will thus paint a comprehensive picture of the formation and evolution of the milky way environment from cosmic dawn until the present day
climatization of eu policies the case of maritime transport

the objective of the research project titled climatization of eu policies the case of maritime transport euclimt is to explore in what ways climatization influences eu governance and impacts the power of the institutional actors to do so the case study of maritime transport will be employed as it is one of the main policy areas indicated in the fit for 55 package as crucial for the decarbonization of the european continent in more detail the project will analyze first the role of the supranational actors in promoting climate policies within the eu with a focus on maritime transport second the implementation of the new green maritime transport policies by key stakeholders within the eu member states and third the impact of the said new policies on the eus diplomatic positions at the international level and how these are perceived by third actors the deliverables of the project will cover a broad array of outputs such as scholarly articles policy briefs podcasts seminars and public lectures in order to ensure the maximum possible dissemination of the results the project will be hosted at leiden university
twinning to develop eltes research and innovation capacity in quantum reservoir computing

quests primary goal is to amplify the scientific prowess and innovative capabilities of eötvös lornd tudomnyegyetem elte alongside its esteemed twinning partners linköpings universitet loughborough university aalto university justinmind sl and intelligentsia consultants sarl they collectively aim to create a quantum reservoir computing qrc system leveraging silicon carbide sic defect qubits over three years quest plans to roll out a research and innovation strategy centered on five core objectives each associated with eight interrelated work packagesobjective 1 is geared towards pioneering research to construct a qrc system based on sic defect qubits this avantgarde technology could potentially enhance computational speed and diminish power usage by over 100 times compared to traditional machine learning modelsobjective 2 emphasizes knowledgesharing between eltes seasoned researchers and the twinning partners facilitated via shortterm staff exchanges seminars and training sessions all complementing the research from objective 1objective 3 focuses on nurturing the career aspirations of earlystage researchers associated with both elte and the twinning entities they propose strategies like brief and intermediate exchanges workshops summer training sessions and a collaborative phd schemeobjective 4 aims to refine eltes administrative and managerial proficiency for european rd initiatives specifically this entails enhancing the expertise of eltes education support office and research support office in aspects like project management proposal drafting intellectual property management and scientific communication concerning european rd funding programmesobjective 5 is dedicated to bolstering the research stature and academic credibility of elte and its twinning counterparts this will be achieved through extensive communication outreach and dissemination efforts
fuelling the future advancements in trifunctional catalysts for renewable biofuel synthesis

the adventurous project harmonizes with the european green deals 2030 climate targets and the broader eu ambition of reaching carbon neutrality by 2050 it is firmly rooted in the pursuit of catalytic trifunctional systems for the transformative synthesis of sustainable advanced fuels saf derived from renewable feedstocks the crux of this endeavour rests upon the innovation of two core facets the integration of catalysts that can seamlessly host diverse catalytic sites and the genesis of an entirely novel synthetic avenue for the production of sustainable aviation fuels saf this project sets forth on a path towards sustainable development poised to chart a course marked by a nearzero emission co2 cycleadventurous leverages the expertise of dr camilla maria cova in organic synthesis and green synthesis complemented under the supervision of prof svetlana ivanova with broad experience in multifunctional heterogeneous catalysis at the university of seville use the fruit of this necessary collaboration will be the advanced design and application of a multifunctional catalyst able to revolutionize the biofuel synthesis what is more advanced technologies such as ultrasoundassisted reactions will be tested for an environmentally sustainable catalyst production and the success of the project will opens a completely new pathways not only to saf production but also to a numerous starting molecules for fine chemical synthesisadventurous is aligned with the msca green charter emphasizing environmental responsibility and sustainable development by developing sustainable biofuels and innovative catalysts it contributes to achieving the objectives of decarbonization energy efficiency and increased use of renewable energy sources in the transportation sector moreover it addresses key challenges of the current energy landscape as supply scarcity and environmental pollution by exploring alternative and renewable pathways for fuel production