Dragon09/odtu_chatbot huggingface dataset:
fully numerical strategy for surrogate modelling of monopile offshore wind turbines

the main objective of funny sumo is to develop a highly accurate 3d numerical model of monopile offshore wind turbines mowt considering simultaneously all the environmental loads current waves wind to be used as a highfidelity model for the definition of a surrogate model that enables the application of datadriven design in the next generation of mowts this project will set the playground for the next generation of offshore datadriven wind turbines and will have an impact on the european industry while boosting the candidates appliedresearch career the cfd and surrogate models will be validated with a recent experimental study by funny sumos secondment the method will be divided mainly into two parts first is cfd modeling where a cfd model will be developed for each load acting on the mowt and then integration in a complete cfd model of the current waves wind effects on the mowt aiming at 80 accuracy relative to experimental measurements the second is developing three surrogate models using the cfd results this project is divided into 5 work packages wps to efficiently achieve the specific objectives of this proposal wp1 deals with management the specific objectives will be addressed within wp24 where wp2 considers meshing and model settings wp3 is the validation of numerical models wp4 deals with the surrogate model definition and wp5 addresses the dissemination activities the results of the project will facilitate europes energy independence by bolstering innovative design processes in mowts based on the application of surrogate models sm furthermore advanced mowts will be manufactured and deployed in the eus geographical area
dynamics of nanoelectromechanical waveguides a computational multiphysics framework

the remarkable electrical and mechanical properties of heterogeneous nano waveguides make it a promising material for nanoelectromechanical devices such as resonators constructed by nanotube and graphene the investigation of heterogeneous nano waveguides can advance the development of the existing energy and wave controlling systems thereby contributing significantly to the exertion of device performance and the reduction of energy consumption however the integration of nano waveguides into functional architectures requires the development of advanced manufacturing approaches which leads to a significant increase of research costs here we present a novel perspective on dynamic analysis of heterogeneous nanoelectromechanical waveguides through a computational multiphysics framework which is based on the homogenization approach equipped with second strain gradient theory this research project will extend the homogenization techniques used in simple waveguides to the heterogeneous nano waveguides and provide a way to considerably reduce the computational effort on the other hand this research project will give new insights on the sizedependent characteristics and enrich the explorations of dynamic properties for nanoelectromechanical waveguidesthis project will be carried out by a talented and dedicated researcher who worked during his phd thesis on wave computational simulation method of heterogeneous nano waveguides through second strain gradient theory the researcher will collaborate with a supervisor who has a very strong background in homogenization approach and in correspondences between second strain gradient theory and programming languages working in sweden where homogenization of nano waveguides is a subject of intense research by many experts in the field the researcher will benefit from his experiences in france and italy which have strong communities on second strain gradient theory and wave computational simulation method
planetaryscale indexing of sequencing data

nowadays a huge amount of planetary dna and rna sequencing data is available and continues to double every two years however efficiently analyzing this data is impossible due to its size measured in petabases many highimpact biological discoveries could be made but are prevented by the lack of fast search algorithms i recently demonstrated this potential by discovering an order of magnitude more rna virus species within all public rna samples a global index ie a planetary genomic search engine would unlock instant and inexpensive search within petabasescale datai hypothesize that i can create a searchable index for all of the public dna and rna sequencing data leveraging my unique expertise across algorithms and data structures for biological sequences my plan is to design efficient methods to assemble and compress all available sequencing data and then construct an externalmemory index that will support versatile biological queriesa planetary sequencing data index will enable a myriad of bioinformatics analyses that are currently out of reach i will demonstrate the utility of the index by constructing a database of human transcripts with novel diseases associations discovering novel microbial species and providing a search engine for environmental metagenomes the resulting unprecedented collection of assembled genomes and compressed reads will lift a major challenge in data accessibility improving its efficiency by several orders of magnitude revolutionizing the scale of future bioinformatics analyses
industrial manufacturing as a service strategies and models for flexible resilient and reconfigurable value networks through trusted and transparent operations

manufacturing industry faces the challenges of driving competitiveness resilience sustainability and circularity in the context of a volatile uncertain complex and ambiguous environment a vuca world calls for new capabilities on the manufacturing systems demanding humanufacturing systems to evolve from industrial automation towards industrial autonomy maas technologies still lack a solid foundation for more active resilience mechanisms that can respond with increased agility to more volatile and uncertainty scenarios m4estro envisions to create an endtoend trustworthy and transparent platform for manufacturing as a service offering active and predictive resilience and timely preparedness to disruptive events m4estro will foster an interactive collaborative and dynamic ecosystem where these stakeholders will operate in a hyperdistributed way to manufacture products by providing and receiving services in a secure and trusted manner it will offer response actions to foreseen risk based on the intrinsic networks flexibility while offer preparedness to unforeseen risks based on the documented resilience to switch action plansto do so m4estro will focus on four 4 pillars offering hw and sw components pillar 1 resilient transparent and flexible manufacturing processes in value chains pillar 2 resilient equipment ai and trusted data for adaptive manufacturingpillar 3 resilient simulations to the industrial metaverse for responsive manufacturingpillar 4 human centred manufacturing resilience and sustainabilitythe impact of m4estro for the european manufacturing industry but also the society itself can be summarised in the following with a horizon of 4 years after project ends i process rampup time 26 ii oee 14 iii yield cpk 11 24 iv product cost reduction 9 v cost per piece 38 vi energy consumption 26 vii about 305 new jobs created and viii over 4289 meur roi for the consortium
leadership for climate resilient buildings

europe has witnessed a significant rise in the frequency and severity of extreme weather events and especially the broader mediterranean region showcases the devastating consequences of climaterelated disruptions climres aims to foster a leadership foeurope has witnessed a significant rise in the frequency and severity of extreme weather events and especially the broader mediterranean region showcases the devastating consequences of climaterelated disruptions unseasonably warm temperatures during the winter months are increasingly becoming a pattern disrupting traditional weather patterns and ecosystems climres aims to foster a leadership for climate resilient buildings by addressing the identification and systematic categorisation of buildings vulnerabilities and estimating their impact in the buildings ecosystem considering the interlinkages within the urban context the project will deliver vulnerability assessment and impact evaluation methodologies along with an inventory hub of measures for building materials and design against climate risks and a decision support toolkit addressing three levels of decision making at strategic tactical and operational levels climres solutions will be tested in 3 large scale pilots in spain greece italy and slovenia evaluating their efficacy against heatwaves extreme flooding fires and earthquakes and one multihazard replication multiplier pilot in france the experiences and lessons learnt from the extensive pilot evaluation will consult the replication roadmap of the project as well as a capacity building programme that will train the next frontier leaders for climate resilient buildings overall the climres leadership will provide valuable insights and guidance for building owners policymakers and stakeholders involved in building climate resilience and sustainable development through the cocreation development deployment and demonstration at trl 68 highly costeffective and replicable solutions
from hodge theory to combinatorics and geometry

we propose an approach to the dodziuksinger conjecture a central conjecture in geometric topology specifically concerning the great challenge that understanding aspherical manifolds can pose based on newly developed tools from combinatorial commutative algebra and combinatorial hodge theory and discuss several intermediate problems along the way the main idea is based on a connection tocommutative algebra via the partition complex an interpretation of local cohomology that allows for a translation between data contained in the l2 cohomology of a manifold and lefschetz properties of toric varieties associated to themadditionally we outline connections to other approaches to the dodziuksinger conjecture as well as special cases such as the hopf and charneydavis conjectures and propose ideas to connect the different aspects of the viewpoints into onefinally we discuss problems related to the methods proposed in particular focussing on unrealised and unexploited relations between combinatorics hodge theory and geometry we discuss in particular deformations of polyhedra and metrics as well as expansion and connectivity
structural basis for membrane protein biogenesis at the endoplasmic reticulum by the snd pathway

onethird of eukaryotic genes encode for integral membrane proteins imps with the majority being assembled at the endoplasmic reticulum er after being translated by the ribosome the srpindependent snd targeting pathway was recently identified as a new route for er targeting and insertion of imps it was found to recognise a subset of imps with a central transmembrane domain yet it also serves as an alternative route to deliver a broad range of substrates to the er when their canonical pathways are impaired the yeast snd pathway comprises three components snd1 snd2 and snd3 the cytosolic snd1 is a putative ribosomeassociated factor and receptor for nascent imp substrates snd2 and snd3 are proposed to form a heterodimeric complex at the er membrane that together with the sec61 translocon mediates membrane insertion of substrates however direct evidence for the roles of the snd components and their physical interactions with each other and complexes such as the ribosome and the sec61 translocon is lackingthis project aims to elucidate the molecular interplays between snd components and other targeting and insertion factors using a combination of structural biology biophysics and biochemistry first i will establish a genomic tagging system to purify snd complexes from chaetomium thermophilum i will integrate mass spectrometry and different biophysical tools to identify and subsequently characterise the interactions between snd components and their associated proteins involved in er membrane targeting and insertion or potentially other novel biological functions ultimately i will solve the structures of endogenous snd complexes by cryoelectron microscopy this work will provide comprehensive insights into how the snd complexes capture a broad range of substrates and execute their er membrane targeting and insertion and will thus have farreaching impacts on our current understanding of membrane protein biology
human ai teaming knowledge and understanding for aviation safety

the aim of the haiku project is to deliver prototypes of ai digital assistants for different aviation segments and users commercial aviation pilots urban air mobility and sky taxis remotely piloted drones remote towers and air traffic controllers it is essential both for safe operations and for society in general that the people who currently keep aviation so safe can work with train and supervise these ai systems and that future autonomous ai systems make judgements and decisions that would be acceptable to humans haiku will pave the way for humancentricai by developing guidance and assurance procedures and by exploring humanai teaming via several interactive prototypesthree main research questions will be addressedwhat is the recommended humanai relationship for each of the different ai applications in aviation what does it mean for ai to be explainable and hence trustworthy in each of these applications how do we best teach ais via humanintheloop ai learning for each of the potential aviation applications the following main outputs are foreseen1new human factors design guidance and methods hf4ai capabilities on how to develop safe effective and trustworthy digital assistants for aviation2a set of aviation use cases controlled experiments with high operational relevance illustrating the tasks roles autonomy and team performance of the digital assistant in a range of normal and emergency scenarios3new safety and validation assurance methods for digital assistants to facilitate early integration into aviation systems by aviation stakeholders and regulatory authorities 4continuous engagement with relevant stakeholders eg policy makers professional associations passengers associations and general public to deliver guidance on socially acceptable ai in safety critical operations and for maintaining aviations strong safety culture record
ads2cft1 holography via quiver quantum mechanics

identifying the nearhorizon black hole microstates which produce the correct black hole entropy formula is a fundamental open problem in theoretical physics and at the same time it is the ultimate aim of adscft holography quiver quantum mechanics captures the bound states of dbrane constituents of 4dimensional extremal black holes it is a unique description compared to all previously known examples of cfts in the context of adscft correspondence because it allows a direct interpretation of its ground states as bound states of bps bogomolnyprasadsommerfield black holes in fourdimensional supergravityconformal symmetry appears in the scaling limit of the effective coulomb branch quiver mechanics we recently developed a geometric gauged sigma model reformulation for this model as a typeb superconformal mechanics it is a powerful interpretation because it provides a differential geometric description for the hilbert space using this formulation as our groundwork we will obtain a definitive result for the ground state degeneracies of the scaling quiver quantum mechanics by applying regularisation and atiyahbott localisation techniques that were applied before for typea superconformal mechanical models furthermore this computation will provide the firstever superconformal index computation for typeb models through the microscopic entropy computation we will obtain an identification of the ground states of quiver dbrane quantum mechanics with pure ads2 black hole microstates and hence the first ever evidence for the pure ads2cft1 holography we will use this result to resolve longstanding problems about the ads2 bps black holes in the supergravity regime for example we will determine the existence of a possible topological quantum hair for ads2 scaling black holes thereby obtaining concrete evidence either for the traditional emptyspace or the fuzzball picture for the horizon neighbourhood of this class of black holes
hydrogen efficient purification using membranes in industrial gas streams

the hermes project advances hydrogen separation and purification technologies through the development scalingup and industrial demonstration at trl7 of innovative membrane systems while conducting comprehensive evaluations for safety environmental impact social acceptance and cost reduction in industrial settingsthe project aims at developing and scaling up two membrane technologies pdbased and carbon based membranes to design and build 2 prototypes at trl7 and to prove the technologies at two industrial sites in italy and in turkey for separation of pure hydrogen for 5 different streams of industrial interestthe prototypes will allow the separation of hydrogen with energy consumptions well below 35 kwhkg and costs below 1 eurokg the project will also evaluate the environmental impact of the processes with detailed lca analysis hermes will also contribute to safety studies of the system and to the public awareness of the technologiesthe project counts with 1 university 2 research institutions and 4 large industries and smes
welfare systems and labour market policies for economic and social resilience in europe

four megatrends technological transformations globalisation climate warming and demographic changes reshape labour markets redefine opportunities and risks and pose new challenges for welfare states in the eu welar aims to fill knowledge gaps about these processes by pursuing two main goals i provide a comprehensive and comparative diagnosis of the effects on megatrends on labour market risks and challenges for welfare states ii develop policy recommendations to adapt welfare states welar contributes to the destinations goal of promoting inclusive growth fair distribution of its productivity gains and boosting economic and social resilience in measuring effects we account for interactions between megatrends and disentangle their impacts of on labour supply labour demand and labour market allocations which are also shaped by institutions we pay particular attention to groups that often face higher labour market risks women young workers people in atypical jobs or in inwork poverty in developing policy proposals we combine simulations with lessons from recent welfare state interventions and social innovation experiments while accounting for political economy of reforms we use an interdisciplinary approach that combines quantitative and qualitative methods and adopts a crosscountry perspective covering the entire eu which allows us to understand the role of countryspecific institutional settings for the effects of megatrends and challenges for welfare states to ensure relevance of policy ideas we engage in extensive consultations and set up feedback loops with stakeholders which complement and validate the quantitative and qualitative studies these stakeholder consultations help to develop concrete policy proposals aimed at resilient inclusive growth we deliver research papers and policy briefs to maximise welars impact we disseminate the lessons learned and policy proposals to policymakers stakeholders and the public
innovative cultivation methods for marine biodiscovery

despite their wellrecognized potential marine bioactive molecules are still difficult to source due to a lack of controlled culturing and processing infrastructures and their chemical synthesis is hampered by their chemical complexity the marine environment is largely affected by global change and wild harvesting of marine bioresources does not represent a sustainable supply of these biomolecules the main sources of the highvalue biomolecules are corals sponges algae involving industrial endusers in the medical and pharmaceutical food and cosmetic sectors therefore new approaches are urgently needed in marine biotechnology as microbial engineering has not fully met the expectations for producing the marine bioactives identified in invertebrates and seaweeds recent advances in thesynthetic biology of terrestrial natural products are offering unique opportunities to supply bioactives of terrestrial origin omics technologies have also transformed the way the complexity of the marine holobiont can be viewed and today the integration of omics data such as genomics and metabolomics can increase our understanding of the functioning and processes of living organisms including their metabolic pathways combo will allow the transfer of knowledge from terrestrial to marine biotechnology through the engineering of marine metabolic pathways using omics approaches the rationale behind combo lies in the power of synthetic consortia of host cells and microbial cells based on the concept of holobiont and auxotrophy to this end we will exploit the recent advances in cocultures systems indeed the development of synthetic consortia has been shown to support specific ecological dynamics promote microbial species growth and syntheses of valuable chemicals combo will therefore expand the potential offered by underused marine sponges and seaweeds known to produce bioactives such as terpenoids and alkaloids for the cosmetic and pharmaceutical markets
law economy and seeing womans work knowledge production and the ilos domestic workers convention in global migration governance

this project will investigate how knowledge production takes place within the context of an international organization io the international labour organization ilo it will look into how what we know about domestic work has developed in the context of the establishment of the ilos convention on domestic work c189 the latter is a landmark global treaty that seeks to set employment standards and norms for domestic workers to date c189 has only been ratified by 33 countries the low ratification rate belies the demand for this kind of worker worldwide this is an indicator of a global care deficit and crisis of social reproduction this demand will not only increase in volume but also scope as the global population continues to age the increasing complexity of these mobilities demand collective action and provision of global public goods this project will examine how various actors engage with an international institution in making knowledge claims about domestic work it will illustrate the contingency of these claims to show that the process by which knowledge about domestic work is created is highly contentious as actors compete over definition of terms scope jurisdiction etc by investigating how science or the authoritative production of knowledge claims informs politics and vice versa this project aims to illustrate what sheila jasanoff calls civic epistemology the institutionalized practices by which members of a given society test and deploy knowledge claims used as a basis for making collective choices this project draws from the sociality of knowledge production in feminist interventions in science and technology studies that attend to different sources of epistemic authority including voices from below the project will proceed in two stages an analysis of the runup to c189s adoption and an investigation of how the ilos normsetting activities diffuse to and from a regional organisation the european union