Dragon09/odtu_chatbot huggingface dataset:
towards an excellence centre on quantum photonics in latvia

the field of quantum technology is experiencing rapid development with groundbreaking advancements by establishing the quantum flagship initiative the european union has taken a proactive approach to quantum technologies this initiative aims to explore and expand the frontiers of quantum technology quantum photonics plays a critical role within this framework in light of this our project seeks to chart a roadmap for the establishment of a centre of excellence of quantum photonics in latvia this endeavor holds significant importance as quantum photonics research remains underrepresented in latvia and the other baltic states despite their untapped potential in materials synthesis and research notably the institute of solid state physics at the university of latvia issp ul stands as one of the most esteemed institutes in the baltic states renowned for its expertise in studying optical properties of materials and conducting research on photonic elements by leveraging the expertise of issp ul and fostering collaborations with scientific partners from latvia and the baltic states we envision the creation of a europeanlevel competitive quantum photonics centre centered around issp ul recognizing latvias latent potential in this field it becomes imperative to develop a comprehensive roadmap for establishing such a centre of excellence to achieve this ambitious goal and facilitate the transfer of knowledge about quantum photonics technologies we have strategically chosen two esteemed western europe universities as our partners the university of trento and the university of technology of troyes both institutions boast a rich history of involvement in quantum photonics research and possess the necessary expertise to bridge the knowledge gaps at issp ul through the organization of conferences schools and workshops our partners will lay the foundations for further research and inovation development at the institute
differential diagnosis of autoimmune hepatitis by cfchipseq liquid biopsy

the identification of the causative agent and mechanism of liver disorders is essential for effective treatment the diagnostic challenge is differentiating autoimmune hepatitis drug induced liver damage and other nonviral causes of liver disease current diagnostic guidelines require in many cases liver biopsy followed by monitoring response to treatment before conclusive diagnosis our objective is to replace liver biopsy in the parenchymal liver disease settings with a minimally invasive liquid biopsy from a blood samplewe have developed cfchipseq a liquid biopsy that enables detection of gene activity in the cells contributing to cellfree dna cellfree dna is mostly chromatin fragments dnaprotein complexes these carry posttranslational epigenetic marks that are closely connected to gene regulation and activity in the cell of origin by capturing fragments marked with active transcription and sequencing their dna we map genomewide activity of genes in the cells contributing to circulating cellfree dnaliver damage results in increased contribution of liver cells to circulating cellfree dna moreover our preliminary results show that we can detect differences in the cfchipseq signal from different liver pathologies and that these differences involve genes associated with the relevant liver damage mechanisms we plan to develop methods for differential diagnosis of autoimmune liver diseases such as autoimmune hepatitis and other parenchymal liver diseases this will be supplemented by a multicenter cohort of patients to train and validate these tools together these will establish a preclinical evaluation of the capabilities of the assay in differential diagnosis and enable development of a product that would change the way we diagnose these diseases this product will improve the quality of diagnosis reduce the number of liver biopsies risk to patients and costs and provide more detailed followup during treatment
the impact of chromatin on the evolution and adaptation of eukaryotes

main hypothesis changes in chromatin drive evolution and adaptation in eukaryotesmain objective this project aims to understand the impact of epigenetic regulation on the evolution of eukaryotes adapted to extreme environments to achieve this objective i will use two approaches involving extremophilic eukaryotes 1 identify chromatin signatures to evaluate the potential roles of chromatin in adapting to extreme environments 2 use experimental evolution to examine how chromatin affects their capacity for adaptationbackground my previous research identified genome size reduction as a broad signature of adaptation strategies in extremophilic eukaryotes in particular an unanticipated loss of several canonical epigenetic pathways took place during the evolution of extremophilic red algae i hypothesize that global changes in chromatin features have influenced the adaptation to extreme environments in eukaryotes strategies i will apply orthogonal strategies to investigate the function of chromatin in environmental adaptability i will use multiomics to reveal adaptation signatures based on the comparison of the composition and maps of chromatin features between extremophilic and mesophilic groups genetic engineering in model red algae will identify the chromatin machinery that impacts adaptation to extreme environments finally experimental evolution will be used to characterize how the specific chromatin composition of extremophilic red algae impacts adaptation capacityimpact this work will establish how chromatin influences the evolution of eukaryotes with direct experimental evidence it will demonstrate how specific chromatin components impact eukaryotic adaptations and eventually identify some macroevolutionary trends that participate in the emergence of new eukaryotic lineages
computing strategy for dataintensive science infrastructures in europe

the amount of data gathered shared and processed in frontier research is set to increase steeply in the coming decade leading to unprecedented data processing simulation and analysis needs in particular the research communities in high energy physics and radio astronomy are preparing to launch new instruments that require data and compute infrastructures several orders of magnitude larger than what is currently available and entering in the exascale era to meet these requirements new dataintensive architectures heterogeneous resource federation models and it frameworks will be needed including largescale compute and storage capacity to be procured and made accessible at the paneuropean level additionally the emergence of highend exascale hpc and quantum computing systems provides new opportunities for accelerating discoveries and complementing the capabilities of existing research htc and cloud facilities addressing key questions around scalability performance energy efficiency portability interoperability and cybersecurity is crucial to ensuring the successful integration of these heterogeneous systems in this context the spectrum project aims to deliver a strategic research innovation and deployment agenda srida and a technical blueprint for a european compute and data continuum with a consortium composed of leading european science organisations in high energy physics and radio astronomy and leading einfrastructure providers covering htc hpc cloud and quantum technologies the project will work with a community of practice composed of external experts the ultimate goal is to pave the way towards dataintensive scientific collaborations with access to a federated european exabytescale research data federation and compute continuum
support to all stakeholders from the photovoltaic sector and related sectors to contribute to the setplan

the etip pv secretariat proposal eupv is designed to restrengthen the european technology and innovation platform for photovoltaics etip pv by implementing a strong and proactive secretariat which will provide effective support to the etip pv governance structures and the working groups it will also further work to ensure that the etip pv becomes the point of reference for all stakeholders especially pv industry but also european and member state officials the project shall continue integrating national or regional pv platforms and strengthening the relations with other organizations supporting the same goals such as eera but also national pv associations and all trade bodies aiming at supporting the development of the european pv industry not forgetting the other etips
inspace manufactured solar array providing highly costefficient power generation for smallsats and inorbit servicing enabling european nondependence and competitiveness in space technologies

inspace manufacturing ism is the key for overcoming the tyranny of launch ie the restriction that all space subsystems are prebuilt on earth and thus must be made to withstand the extreme mechanical loads at the launch of the rocket all while fitting into tight volumetric restrictions ism will save material and circumvent the limits in dimensions and massdcubed leverages ism for making solar arrays for satellites directly in space this is especially important for small satellites smallsat such as in internetfromspace constellations to satisfy increasingly high power demands at a fraction of the cost of conventional solar arrays smallsats play a big role in the growing newspace economy and the global space market which is expected to reach 1879b by 2032with our advanced ism technology for building solar arrays inorbit we will become technology and market leader based in europe thus ensuring european competitiveness and nondependence in space technologies
breakthrough technologies for an implantable artificial kidney

chronic kidney disease is a worldwide and evergrowing health crisis in which endstage patients largely depend on intramural dialysis placing a heavy burden on their life and on european health care systems kidnew develops groundbreaking and modular technology to enable an implantable artificial kidney with better functional kidney replacement therapy krt than currently available without need for immunosuppressive drugs and at reduced costs it provides proof of concept on three breakthrough technologies 1 solidstate miniature ultrahigh flux silicon sibased filter with a highdensity of uniform nanopores through novel block copolymer selfassembly and with novel hemocompatible biomimetic polymer polymer brush coating connected to a photonic clotting monitoring sensor and thrombolytic cleansing tool 2 solidstate bioreactorgrown kidney tubule cell monolayers on novel biomimetic siwafer based membrane with bioimpedancebased monolayer integrity monitoring and monolayer repair functionality using growthfactors 3 solidstate integrated functional biohybrid filter and tubule exchange units stacked in parallel in a multichip to demonstrate functional implantable krt in goatsan implantable bioartificial kidney will provide more effective more physiological and economical sustainable krt than dialysis ecofriendliness of proposed technologies in line with the eu green deal has recently been highlighted by the european kidney health alliance on the short to midterm the filter andor tubule unit may enter nichemarkets for extracorporeal use in complementing rather than replacing current dialysis solutions kidnew brings together scientists from the fields of clinical and regenerative nephrology umc utrecht nl regenerative pharmacology university utrecht nl chip technology imec nl and imec be optical sensing optofluid technologies oü ee blood compatible coatings cnrs fr and membrane technology mesep pl
new directions for deep learning in cancer research through concept explainability and virtual experimentation

deep learning dl is rapidly transforming cancer research and oncology dl can extract subtle visual features from preclinical and clinical image data in my junior research group i have developed endtoend dl methods to predict molecular biomarkers and clinical outcomes directly from histopathology slides because histopathology slides are ubiquitously available for any patient with a solid tumor dl is a broad tool for translational studies enabling researchers to extract molecular information and make predictions about clinical outcomehowever the potential of dl in cancer research is fundamentally limited because it is purely descriptive and in many cases a blackbox system also dl is currently disjoint from the vast amount of biological mechanistic knowledge in cancer research and from the world of experimentation in nadir i will close this gap my hypothesis is that dl models can not only make predictions but can be used to verifyexisting biological knowledge and to make new mechanistic discoveries the main tools that allow me to address this are concept explainability and counterfactual virtual experimentation for both there exists a nonmedical proof of concept but no systematic biomedical application yet i approach this problem as a biomedical cancer researcher with training in programming medical image analysis and biomedical engineering as such i will develop dl systems that can extract biological concepts can elucidate biological mechanisms and can be used to create and answer mechanistic hypotheses nadirs tools will be synergistic with and can be used together with other biological highthroughput experimentation pipelines such as transgenic animal experiments or tumor organoid cultures the main use case of nadir is focused on tumorimmune interaction in colorectal and gastric cancer and through the educational and outreach program in nadir it will be made available as a general tool for cancer researchers in biomedicine
noncorrosive polymer electrolyte with preferential al3 transport for rechargeable aluminum batteries

rechargeable aluminum batteries rabs are extremely promising due to inherent safety high theoretical volumetric energy density 4x of li and low cost of al metal 10x cheaper than li rabs can play a crucial role in ensuring and securing an affordable and safer eu energy supply in line with the eu green deal however the development of rabs is hindered by a lack of practical electrolytes the current stateoftheart soa ionicliquid electrolytes are extremely corrosive moisture sensitive expensive and do not offer al3 cationic species relying on the synergy between the researchers background and the hosts expertise the ncpepa project introduces an innovative and beyond the soa concept to develop a noncorrosive polymer electrolyte with preferential al3 cationic transport with high ionic conductivity objectives of the project address overall issues of the soa electrolytes this project will have a significant scientific and societal impact as ncpepa electrolyte promises the development of safer affordable and highenergy density rabs that will be pivotal to clean and green energy transition additionally it contributes to the enhancement of the eus scientific excellence being the leader of the energy storage materials subgroup within the multifunctional nanocomposite group at imdea and with a proven track of contribution in the field dr pendashteh a is the most appropriate supervisor the host institute imdea is also acknowledged as one of the best research institutes in spain with proven experience in developing materials and systems for batteries and immense experience in marie curie fellows hosting and project management the project will advance the researchers professional development and career growth by providing multidisciplinary skills along with access to management and related training that will equip the researcher to achieve his longterm goal of establishing a research group focused on developing sustainable batteries
renewable energy sources power forecasting and synchronisation for smart grid networks management

renewable energy sources power forecasting and synchronisation for smart grid networks managementrenewable energy sources res play a major role to the eus aspiration to transform to a climateneutral economy their integration into the power grid is pivotal to the green transition and to the decarbonisation of the energy sector however as the most commonly used res solar wind and hydropower are also weatherdependent their power generation capacity varies according to the local microclimatic conditions this power production variability makes res difficult to integrate into the power grid and to provide seamless stable and secure amounts of power on the other hand power demand also affects the power grid operation since there must always be a supplydemand balance in the power grid grid power imbalances can cause frequency fluctuations and other unwanted transient phenomena which can compromise grid stability and operation for that matter advanced grid monitoring techniques have been developed employing phasor measurement units pmus to measure the electrical signals in a precise and synchronised way based on a reliable timing reference yet currently no galileobased applications on pmu timing exist in the above framework respondent comes to address the challenges of res power generation forecasting demand forecasting and smart power grid monitoring and supplydemand balancing an aiml res power generation forecasting algorithm is proposed exploiting both copernicus eo and sitespecific weather data along with renewable energy power conversion models furthermore an aiml multiphysics model for power demand of certain communities is also developed lastly respondent will build a galileoenabled pmu and develop a monitoring module in order to test and verify the advantages offered from the galileo timing and synchronization services in smart grid monitoring power balancing and overall operation
counterfeit detection validating the artdetect approach with stakeholders in the loop

forged paintings pose an urgent challenge to international law enforcement agencies and the art world both the quantity and the quality of the works are alarming in practice however this type of art crime is notoriously difficult to detect and combat the cog project artdetect is generating new knowledge about significant anomalies that betray forged paintings as well as into key characteristics of comparable originals and is developing thinslicing tools ie computer programs and checklists that help to quickly and effectively select potential forgeries for indepth analysis however in order to ensure the practical application of the new knowledge and tools it is crucial to engage with stakeholders at an early stage in order to 1 gain access to a wide range of current cases 2 test the validity of the preliminary conclusions and 3 identify the challenges and opportunities in this restricted part of the marketthe team has a unique opportunity to collaborate with stakeholders and gain access to a large number of potential forgeries in the styles of more than 100 modern painters we are also setting up our own lab these circumstances allow us at relatively low cost to build an extensive curated image database of real cases to carefully annotate the images and to rigorously validate our preliminary conclusions through indepth confidential research with stakeholders codes will provide an extensive test dataset and useroriented guidelines that have the potential to revolutionize counterfeit detection
the evolution of new organs during insects conquest of the sky

the history of life on earth has been defined by key gamechanging events in animals this has often been driven by the appearance of novel organs conferring new capabilities to explore new niches and adaptive landscapes completely changing the subsequent evolution of certain lineages this proposal will focus on one of the most fascinating and revolutionary events in animal history insects conquest of the skies first by addressing the origin of the morphological change responsible for this revolution the origin of wings second by studying one of the multiple cascading effects set off by this initial event that continued shaping flying insects anatomy and boosted their diversification the turbanate eyes of mayflies a sexspecific extra set of eyes that males use to find mates during flight we still know very little about these two events due to the lack of data from key species and the need for multilevel and quantitative approaches my lab will overcome these difficulties by using a unique experimental platform that i have built over the last five years the setup of mayflies a key group to study insect evolution as a new experimentally tractable modelwe will study the genetic basis and key factors underlying the origin of these two organs with a multidisciplinary view combining single cell omics developmental and functional approaches and in the case of new eyes their impact in physiology and diversification by comparing these two evolutionary processes we will unveil key common and specific events in the evolution of the gene regulatory networks behind the origin of these two new organs this project will generate the most comprehensive picture of two novel organs with huge impact in the evolution and ecology of winged insects and mayflies answering longstanding evolutionary questions on morphological novelties this will have a major impact in the way we study and understand the origin of new forms and their transformative nature
development and commercialisation of a next generation sports head guard embedded with clinically validated sensors for the detection of sports induced brain injuries

10 of all contact sport athletes in rugbyfootballbaseballboxing sustain regular concussions mild traumatic brain mtbis injuries due to linear rotational head impacts globally 4mannum mtbi incidents are reported in contact sports with 201 concussions per 1000 player hrs concussion is the most common reported match injury occurs in 81 of the matches currently concussionsmtbi managementtreatment costs eu 17bannumno existing headgear is clinically approved to provide protection against linear and rotational impacts hence fail to reduce concussion incidentscontego sports are developing worlds first clinically approved headgear for contact sports nprosend which will reduce all linear impacts by 75 rotational by 55 as compared to existing headgear nprosend will also provide early detection of concussionmtbi by processing cumulative effect of head impact data collected by embedded iot enabled triaxial sensors and processed by ai algorithms