Dragon09/odtu_chatbot huggingface dataset:
understanding monitoring and remediating the spread of chemical microbiological and plastic pollution in drinking water treatment plants

niagara compiles all the necessary approaches to provide a comprehensive response to the phenomenon of spread of pollution chemical microbiological and plastic from drinking water sources to human exposure through the driking water treatment plants these approaches and their solutions are1 realtime monitoring niagara will develop multianalyte biosensors able to quantify simultaneously 4 highly concerning pollutants of very different chemical nature bpa imazalil h pylori and paracetamolibuprofen using preconcentration units detection limits will reach pgml for chemicals and 10100 viable cells for h pylori which are below harmful levels for human exposure2 remediation a removal and disinfection system based on a tandem formed by two ieds biofilters immobilizedenzymes degradation systems and a uvtio2 photoreactor with this solution we will achieve total removal of the 4 analytes concentrations below detection limits of water laboratory techniques and a total organic carbon removal of 70 exceeding current state of art the dbps formed will be identified and their appearance mechanisms and toxicity will be predicted3 a fast and costeffective method for realtime monitoring of the propagation of these 4 contaminants using a hydraulic model that exceeds the performance of current methods seconds vs weeks 60 accuracythese solutions will be validated up to a pilot scale trl5 in a case study in the city of valencia in a dwtp and using the drinking water supply system of district 9 jess with the participation of the municipal drinking water company and accomplishing safety and sustainabilitybydesignfinally the communication and exploitation plan has been specially designed to have an clear projection ouside eu to enhance its competitiveness in the water sector and to foster its position and role in the global water scene with the participation of previously established eu and noneu networks
mapping the brainspinal cord interaction towards understanding and treatment of movement disorders

movement is one of the most important activities in our everyday life it is an essential element for maintaining overall health and wellbeing with more than 1 billion people globally suffering from a neurological disease that directly affects their movement each year more than 15 million people experience a stroke in the eu alone leading to death paralysis or some kind of disability this is a significant burden on healthcare systems with no cure we must address the questions how do we move what is the underlying physical mechanism of the brainspinal cord interaction that orchestrates the generation of movement to be able to answer those a highperformance bidirectional interface is required move2treat explores disruptive science by developing a new brainspinal cord interface to investigate the associated neuronal circuits in fact move2treat has 3 distinct breakthroughs 1 a novel theory on movement generation by rotating ensembles validation the neuronal population activity across central brain regions and the spinal cord 2 a bidirectional softfiber platform as neural interface to brain and spinal cord in freely behaving species 3 validation of theory 1 and neural interface 2 in the disease models the developed theory and implant enable the nextgeneration pacemaker of the nervous system based on the first complete minimally invasive wireless biocompatible and soft multifunctional fiberbased neural interface to map the brainspinal cord activity by simultaneous stimulationrecording in vivo and realtime with high spatial and temporal resolution move2treat is a european approach to establish technological sovereignty delivering the nextgeneration precision sensing for neurological science
enabling decentralised digital twin era in existing research infrastructures for predictive preventive personalised and participatory health

in the face of a rapidly advancing digital healthcare terrain the dtrip4h project emerges as a momentous effort to revolutionize predictive preventive personalized and participatory health paradigms within the eu amid significant incidence of chronic conditions and cancer there is a pressing need for a proactive shift in health strategies yet the full potential of european research infrastructures ris is curtailed by investment deficits fragmentation and the intricacies of data management digital twin dt technology introduces a new age of precision by enabling sophisticated simulations and analyses of intricate biological processes in dtrip4h we start a new initiative in europe decentralized health digital twin ecosystem consisting of ris using dts we aim to resolve critical challenges around data harmonization equitable access and stringent privacy safeguards incorporating technologies such as federated learning generative ai and virtual reality vr the project aspires to create a decentralized digital twin environment ddte this will empower both internal and external ri users such as researchers innovators and smes to craft dt applications that address specific scientific challenges utilizing a blend of realworld and synthetic data in compliance with regulatory frameworks ie gdpr we will develop 7 innovative proof of concept thematic healthrelated use cases fulfilling the needs of scientists smes and industrial end users particularly in health topics related to cancer treatment drug development human environmental exposome precision treatment for schizophrenia and personalized medicine through artificial intelligence ai arvr empowered dts utilizing ddte while adhering to fair data principles dtrip4h adopts a humancentric methodology to elevate research efficacy narrow the skills gap and align with the objectives of the european research area era and the sustainable development goals sdgs by 2030
empowering the geopolitical eu in the eastern neighbourhood and the western balkans

geopowereus main objective is to contribute to the empowerment of the eu to manage security threats within the deteriorating geopolitical environment that lies in its eastern neighbourhood and in the western balkans the projects main ambition is to go beyond thestate of the art and articulate a proposal for a comprehensive eu strategy towards these regions that will employ new and reformed means and policy instruments taking into consideration foresight concerning the strategic ambitions of other geopolitical actors to address this ambition geopowereus workplan builds on 6 specific objectives i propose ideas for the adaptation of eu enlargement policy to the new realities ii interrogate the continued relevance of the eap and articulate policy prescriptions for its reform iii assess the influence of other geopolitical actors united states russia china and turkey in the two regions iv provide strategic foresight about the prospects of geopolitical competition in the two regions v explore the growth of the eu ability to contain military threats from the deteriorating geopolitical environment beyond its borders vi propose a comprehensive and multidimensional eu strategy that will guide relations with the wbeap countries the projects research results will go beyond the state of the art to advance a new conceptual framework and an innovative policy framework built on the use of quantitative and qualitative methods in the policy cycle in terms of methodology the project is mobilizing cuttingedge expertise from different disciplines to implement a multistage plan grounded in a participatory and inclusive approach with all partners contributing to data collection and processing the projects participatory and co creation methodology relies on the systematic involvement of researchers from third institutions decisionmakers stakeholders and citizens including in the regions being analysed throughout the project cycle
gatbio next advancing grts 1st oral biologic gbaf004 to clinical demonstration and outlicensing

gat biosciences gatbio is a womenled biotech sme targeting the exploitation of its proprietary grttm technology as a novel solution for the development and production of complex biologic drugs for biopharma and veterinary markets specifically we are developing a gamechanger next generation of accessible and noninvasive oral topic inhaled biopharmaceuticals through proprietary and sustainable microalgae biofactoriesour first candidate for the biopharmaceutical market gbaf004 will enter preclinical demonstration in 2023 gbaf004 is an antiinflammatory biologic for the oral treatment of inflammatory bowel diseases and disorders ibds the term ibds includes a range of chronic and painful autoimmune diseases affecting localy the intestine affecting patients from their youth and throughout life and of unknown causess more than 6 million people are affected by ibds globally and their global treatment market is estimated by 2029 at 37 billion euros per year gbaf004 has the potential to be a gamechanger in the treatment of this high prevalence and chronic inflammatory intestinal diseasesgatbio has been recently granted a seal of excellence from the eic accelerator program supporting disruptive european smes for their acceleration to the market the related funding will allow us to enter the preclinical development of gbaf004 early in 2023 in this frame additional support related not to scientific development per se but to reinforcing our strategic business management and vision could be key to success in our next steps and culminate gbaf004 outlicensing specifically to access expert mentoring and biomed advice related to i clinical positioning in the ibd market and ii outlicensing strategy would be key to success in the arrival of our 1st candidate to the regulated market and would translate into gatbios consolidation and exponential growth based on innovation outlicensing
future availability of secondary raw materials

the future availability of secondary raw materials futuram project seeks to 1 develop knowledge on the availability and recoverability of secondary raw materials srms within the european union eu with a special focus on critical raw materials crms to enable factbased decision making for their exploitation in the eu and third countries and 2 disseminate this information via a systematic and transparent secondary raw materials knowledge base srmkbthe futuram project will establish a methodology reporting structure and guidance to improve the raw materials knowledge base up to 2050 and facilitate the exploitation of srms with a particular focus on crms the project will integrate srm and crm data to model their current stocks and flows and consider economic technological geopolitical regulatory social and environmental factors to further develop demonstrate and align srm recovery projects with the united nations framework classification for resources unfc the project will address the following waste streams batteries waste electrical and electronic equipment endoflife vehiclesmining waste slags and ashes and construction and demolition waste futuram will further develop and test the unfc methodology through 18 case studies across the six futuram waste streamsfuturam research into the future availability of raw materials is relevant to the specific aspects of the work plan it will contribute to atransition to climateneutral circular and digitised economy develop an understanding of anthropogenic resources develop thenecessary criteria to establish a resource classification approach combine new existing data and present it in a unfc formatdevelop a proposal for eu statistics for srms and contribute to raising awareness of raw materials supply challenges in the eu andthe possible solutions
a novel noninvasive and nonionizing medical device for monitoring patients with implanted stents

susana amors is the cto and cofounder of nimble diagnostics a medtech company developing a first in class microwavebased medical device for the continuos noninvasive nonionizing monitoring of patients with implanted stentsstents are one of the most implanted devices worldwide and are used to restore the correct flow of blood or other fluids they are especially useful to prevent heart attacks or to treat their lasting symptoms but once implanted can become blocked or damaged which occur in 30 of the cases the symptoms only appear after a stent is already 90 dysfunctional which increases the incidenceof serious complications including strokes heart attacks or sudden death the standardofcare is still symptomdriven and is based on an invasive procedure called catheter angiography involving anesthesia xray exposure and 24h hospitalization recovery this complex procedure is not standardized for recurrent monitoring not allowing clinicians to act upon the problem until it has already manifestedthe nimble system can read the electromagnetic signature of the stent noninvasively providing information on stent satus and malfunction that can be correlated with relevant clinical outcomes thus nimble enables early treatments to prevent negative outcomes and personalization of pharmacological therapy shifting from reactive to proactive care our technology is currently at trl5 with an mvp that has shown and excellent results in ongoing validations however before we can offer our solution to cardiologists and primary care clinicians we must complete key activities in our action planwomentecheu will help us to better understand pricing and reimbursement strategies for the nimble system in european markets gain visibility with investors and collaborators and support and mentoring from being one of the growing numbers of female entrepreneurs susana expects that this program supports her in bringing nimble system to the market
a university partnership for acceleration of european universities

aupaeu is based on the collaboration of five academic institutions from two european alliances under the european universities initiative epicur and unite who are working together to integrate and implement acceleration services in the context of a coordinated support system for higher education institutions heis networks alliances of universities and their umbrella organisationsthe partners are experts in identifying effective approaches for ri modernization that might serve as a model for other european heis networks and partnerships each partner has made significant internal efforts to advance their institutions has sought new development routes through the european university alliances and has contributed to a variety of european and regional university networksaupaeus ultimate purpose is to develop methodologies sustainability plans coaching services and tangible digital technologies to give an acceleration agora heis university networks and alliances will achieve integrated shared and longterm ri transformations through this accelerated agora these transformations are intended to focus on six major areas of the hei transformation agenda capacity infrastructure and resource sharing researcher career attractiveness collaboration with ri ecosystem actors open science societal outreach and gender equalityfollowing the greek concept of the agora the project will attempt to build a shared space where all stakeholders can give and consume accelerated services while also contributing their knowledge and experience access to this place will be accessible diverse and inclusive promoting the reduction of all sorts of disparities including economic gender and other inequalitiesfinally the project will deliver this agora which will be evaluated by the user groups of two alliances and will serve as a model for other heis networks or university alliances to emulate
computer aided de novo design of nanobodies

antibodies have become major players in the pharmaceutical industry and were valued at 016 us billion in 2023 traditionally antibodies are obtained after immunisation of different animals and then produced in relevant cells for use in research diagnostics and therapy in recent years there is a growing public opinion in europe to ban the use of animals for biomedical research and therefore there is an increasing pressure to move from animal produced antibodies to design and produce them in vitro antibody engineering has another important advantage which is the possibility of targeting a precise epitope and not rely on serendipity as when injecting an animal with an antigen in recent years there have been significant advances in protein design based on the use of artificial intelligence and precise force fields despite this the majority of the companies that work on antibody design combine rational engineering with massive proprietary screening methods and so far there are no reported cases of fully de novo design of an antibody with nm affinity against a defined epitope using an interleukin receptor as a case study we have shown that we can indeed fully design de novo a nanobody that recognizes the target with nm affinity using our proprietary protein design software foldx and modelx experts consulted to date indicate that the results obtained so far are truly impressive prompting us to continue validating and optimising our process our proposal has two main objectives first to fully automate our pipeline that involves epitope selection antibody framework selection and docking backbone move and side chain search second demonstrate that our optimised pipeline can design fully de novo nanobodies against a defined target in a fast and costeffective way success in both objectives will open the way to fully de novo antibodies with desired properties and position ourselves in the search for funding and spinoff incorporation
the long emergency the postcolonial state labour and the railway strike of 1974

the railway strike of 1974 the last general strike on the indian railways involved over two million workers and brought the national economy to a standstill at once the strike became a visible and powerful symbol of india in crisis in june 1975 prime minister indira gandhi of the congress party declared the state of emergency marking a turning point in indias postcolonial history yet the two events have not been placed in one historical frame the historical processes that congealed to produce a profound break in indian politics from democracy to authoritarianism remain largely unexamined through a long history of the emergency with a central focus on railway labour this msca project will unfold one of the multiple crises of the postcolonial state of which the emergency was symptomatic that of nationbuilding visavis the labour question in doing so it clarifies the place of labour in postcolonial politics at the same time as illuminating the character of the developmentalist state in india as a historical formation more broadly it includes a comparative perspective and thus illuminates the dynamics of the expansion of postcolonial states ambit towards labour welfarism as well as its recourse to open authoritarianism the project stands at the interface between modern south asian history global labour history and the history of crisis and dictatorship in the third world
a new light on isocyanide synthesis

susisocyanide is an ambitious project that aims for the sustainable synthesis of isocyanides by combining biobased feedstock visible light and flow chemistry the aim is to accomplish an economically viable and ecofriendly large scale synthesis of this fundamental and highly versatile building block that has already found widespread appreciation in academia but suffers from underutilization in the pharma finechemicals and materials industry in accordance to the european green deal the devised methodologies will provide an expedient synthetic platform to achieve the automatic synthesis of isocyanides without the need of toxic and hazardous reagents and avoiding substantial waste production this will constitute a groundbreaking improvement far beyond the current stateoftheart especially considering that the traditionally employed synthetic procedures towards isocyanides have hindered largescale preparation and therefore industrial utilization in light of the main goal susisocyanide will constitute a launching platform for the fellow since the interconnection between his expertise in photoredox catalysis and flow chemistry and the experience of the host group maastricht university in isocyanide chemistry provides fertile soil for fruitful collaboration and success because of the close collaboration in this project with brightland chemelot campus the fellow is trained in the industrial utilization of isocyanides in polymer synthesis and advance functional material applications this highly complements his academic knowledge with industrial application of the developed ideasoverall susisocyanide will provide a sustainable alternative for the synthesis of isocyanides taking into account further implementation through industrial applications the use of simple green feedstock in combination with enabling technologies is the key element that makes the difference to achieve the overall aim and objectives presented
elastocaloric cooling and heatpumping

decarbonization of the heating and cooling sector with renewables is a crucial step for the eu to achieve its energy and climate goals although heat pumps are considered renewable technology they are all as well as cooling and airconditioning devices based on relatively inefficient vaporcompression technology that still uses environmentally harmful refrigerants the kigali amendment mandates phasing out highglobal warming potential refrigerants such as hydrofluorocarbons in the eu by 2036 and replacing them with ecofriendly natural refrigerants however natural refrigerants have their own limitations including flammability toxicity high operating pressure and lower efficiency in hot climates recently elastocaloric technology has emerged as the most promising nonvaporcompression alternative it is based on safe environmentally benign solidstate refrigerants and may offer higher efficiency than vaporcompressionthe erc poc ecoheat project evolved from the erc stg supercool project in which we explored fundamental aspects of elastocaloric technology based on this research we have developed a fatigueresistant elastocaloric regenerative cooling and heating device with breakthrough performance and an efficient drive mechanism this device serves as the foundation for the ecoheat project with the main objective to elevate the readiness level of elastocaloric technology in various areas including technical aspects customer engagement business strategy and ipr after fine tuning the elastocaloric device it will undergo industryrelevant testing to achieve technology readiness level 5 and ip protection of the most innovative solutions these achievements will form the basis for disseminating the results to our future potential industry partners elaborating a comprehensive business model and pursuing laterstage funding opportunities to further improve the readiness level of the elastocaloric technology and bring it closer to the market