Dragon09/odtu_chatbot huggingface dataset:
the queens post the form function and power of early tudor queens correspondence

the queens post project provides the first largescale analysis of the form function and power of early tudor queens correspondence this project investigates the letters of nine important early tudor queens including the wife of henry vii d1509 elizabeth of york d1603 henry viis daughters margaret tudor d 1541 and mary tudor brandon d1533 and the wives of henry viii d1547 katherine of aragon d 1536 anne boleyn c1536 jane seymour d1537 katherine howard d1542 anne of cleeves d1557 and katherine parr d1548 using an innovative interdisciplinary methodology employing methods from linguistics literary studies archival studies material culture gender studies and diplomatic history the queens post will advance our understanding of the nature and power of royal womens voices and writings of the past and reconsider the power and position queens held in early modern politics and diplomacy the results of this project will have distinctive scientific and societal impact which will be disseminated via a range of outputs aimed at both academic and nonacademic audiences this includes a project monograph an edited collection a symposia a podcast and various other outreach activities the project will also provide a significant methodological contribution to letterwriting studies by developing a cuttingedge interdisciplinary framework of analysis to investigate the language materiality and delivery of historical correspondence across a network of writers
resilient industry supply chain enhancement for smes

risesme aims at developing a model that can assist companies in detecting and anticipating disruptions in their supply chains the main outcome of risesme is to build a methodology for different industrial ecosystems that can identify disruptions and technological opportunities for the uptake of advanced technologies in smes so as to enable flexible agile and resilient supply chains that can easily be adapted in order to do so the following activities will be deployedmapping of existing industrial ecosystems and its associated supply chain models in order to identify critical dependencies and weaknesses in specific industrial ecosystemdeveloping a methodology for detecting and anticipating disruptions with long term effects on the supply chain to reduce strategic dependencies on critical products especially on advanced technologiesmapping and scouting advanced technologies and their associated solutions from technology suppliers that can help supply chain processes to be less uncertain and complexanalysing existing technology gaps in several industrial ecosystems leading to a matchmaking tool with techsavvy and traditional smesbuilding alliances among traditional and techsavvy smes through cluster organisations and dihs in the industrial ecosystem resulting into the launch of a pilot in each one of the ecosystemsthe project consortium will leverage their knowledge on supply chain and their reach to key supply chain actors traditional smes and technology suppliers the involvement of technology partners and entities representing techsavvy smes will ensure a thorough consideration of the following advanced technologies robotics ai iot blockchain edge computing arvr solutions b2b digital platforms big dataanalytics technology 3d printing advanced materials micro and nanoelectronics nanotechnologies and photonics among others
circletech twinning partnership to deliver enhanced networking for circular technological and socioeconomic impact raising research excellence and strengthening management capacity

the present proposal is to respond to multiple programme priorities firstly to enhance the participation of underperforming member states in the framework programme together with contributing to solutions for the major challenges of the european union in research fields as defined in the horizon europe programme with a focus on challenges connected to the transition towards a sustainable circular economy and specifically technological and socioeconomic aspects of the transition of relevance are challenges under cluster 4 digital industry and space destination climate neutral circular and digitized cluster 5 destination crosssectoral solutions for the climate transition destination efficient sustainable and inclusive energy use the project proposes measures to offer practical responses to barriers for participation in horizon europe and achievement of excellent research results increasing scientific visibility of the university of miskolc um with the networked support of technische universiteit delft tudnl and lappeenrantalahti university of technology lutfi increasing scientific excellence in the traditional sense will be the aim of this joint exercise where um with its excellent partners will develop new promising research actions and test novel approaches in this research domain opening future perspectives in the field of research for sustainable circular economy the university of miskolc has a special interest in materials sciences and is focusing on excellence in research for a more sustainable circular economy our primary objective will be raising scientific excellence of the university of miskolc in the field of sustainable circular economy research forming a long lasting research hub circletech hub across northern hungary the creation of the operating framework of joint research will help setting up the basis of long lasting research cooperation in the field of sustainable circular economy for joint research ideas
geometric algorithms for transport network graphs

graphs have been used to analyse transport networks for hundreds of years however graphs are general structures and many graph algorithms are very slow specialised algorithms are much more efficient but can only be applied to restricted graph classes transport network graphs suffer from a lack of efficient specialised algorithms since most graph classes are too restrictive and do not accurately represent realworld transport networks recent developments have led to geometric graph classes that are tailored to realworld transport networks one of these geometric graph classes philowdensity graphs captures the property that there are more connections between geographically nearby nodes than geographically distant ones unfortunately the fundamental properties of philowdensity graphs are not well understood which has prevented the development of a wide range of specialised algorithms my objective is to fill the acute need for a simple and versatile graph class that accurately represents realworld transport networks my research will allow experts to finally harness the power of specialised algorithms on a wide range of important transport network problems i will achieve my objectives through two subobjectives 1 to build fundamental structures for philowdensity graphs and 2 to design provably efficient specialised algorithms for philowdensity graphs i will be support by my host institution university of copenhagen my host group basic algorithms research copenhagen my primary supervisor mikkel abrahamsen and my secondary supervisor rasmus pagh
futuring peace the politics of water conflict in a posttruth age

the international peace and security architecture is undergoing urgent change to accommodate a conflict environment that will be increasingly shaped by the quality of environmental governance in a context of climate change water problems with its associated drought wild fires and flooding are at the centre of changing conflict dynamics the 2021 report of the independent panel on climate change ipcc devoted 200 pages to this issue alone highlighting the vulnerability of weak states and agricultural communities within them to water conflict stemming from poor regulation of access to scarce resources in addition to a rise in water conflict peace and security policy and practice is also adjusting to a global context of rapid technological geopolitical and normative change climate change and advances in technoscience are intricately linked in the uns futuring peace initiative which explores the possibility of using big data machine learning and social media to inform climate conflict prevention activities the digital expansion of public space has also facilitated posttruth politics which denotes the use of digital technologies by rising illiberal authoritarian and populist powers to question or fabricate scientific facts about global issues including both climate change and military conflict climate conflict narratives have placed peacebuilding practice between the objective truth claims of big data and the ontological condition of ambiguity or multitude of truths regarding climateconflict risk this project will focus on how the interrelated issues of climate change technology rising illiberal global powers and posttruth politics cohere around water resources to influence conflict dynamics and the norms that underpin international peace and security intervention it will involve a qualitative case study of international intervention water governance and water conflict in the ferghana valley in central asia
microscopic mesoscopic and macroscopic approaches to mitigate micro and nanoplastics in the food and environment

the proposal microscopic mesoscopic and macroscopic approaches to mitigate micro and nanoplastics in the food and environment 3m2mnpfe is an msca pf proposal to be hosted by the university of malta for 24 months wherein dr floirendo flores will be supervised by dr sophie marie briffa following the 24month fellowship a nonacademic placement nap has been secured with commitment from dr adrian c love acl from aquabiotech group abt dr flores conducts research on microencapsulation of bioactive compounds and simulated digestion whereas dr briffa specializes on nanoparticles chemistry synthesis characterization and environmental behavior the comentor dr melissa marie formosa has in vivo studies involving zebrafish larvae and currently has supply agreement with abt plastic packaging polymers are a necessary component of food products that are often discarded in municipal solid waste treatment plants and landfills resulting in varying levels of degradation products the degradation products are usually recalcitrant micro and nanoparticles mnps that enter aquatic environments and contaminate biota with potentially adverse health outcomes in view of the pressing need to mitigate the environmental risks upon exposure to mnps an interdisciplinary approach combining polymer chemistry food nutritional and animal sciences is being proposed to develop an environmentally sound enzymatic technology to treat mnps enzymatic treatment can change mnp size and enhance biodegradability new knowledge will be generated on in vitro and in vivo changes on enzymebased gastrointestinal and antioxidant systems following exposure to enzymatically treated mnps implementation of the work packages will help answer the research question does exposure to enzymatically treated mnps codigested with food reduce the toxicity risks of mnps results of this project can lead to a new sustainable pollution control strategy
driving the future of water resource recovery facilities through data intelligence

the wastewater sector is going through a profound transformation with energy efficiency and resource recovery as key priorities in wastewater treatment plants wwtp and these installations started to be perceived as water resource recovery facilities wrrf under this context the exploitation of data through artificial intelligence tools with the objective of accelerating the transition of wwtp to wrrf has not been fully addressed yet when compared to treatment technologies the deployment of aipowered tools in production is much faster and therefore provides immediate benefits in that sense three main barriers have been identified in this domain i mechanistic mathematical models involve complex formulations and specific terminology that are difficult to understand for plant operators ii wrrf are harsh environments with strong impact on the quality of data iii essential information in wrrfs is limited and not continuously availablein particular to overcome these challenges darrow will build and demonstrate into an operational environment an innovative optimised modular and flexible datadriven ai solution to make existing wwtp more autonomous more energy efficient and better prepared for their transformation into wrrf darrow will take advantage of existing ai data analysis techniques with the final objective of contributing to a greener planet by i reducing energy consumption of wrrf ii reducing greenhouse gas emissions of wrrf iii increasing resource recovery iv improving water qualityto do so darrow gathers the necessary experience knowledge and resources through a multistakeholder approach that covers the whole value chain of the project it consists of a multidisciplinary team of 8 entities from 4 different eu countries spain belgium germany and netherlands among which 3 rtos 1 university1 npo and 3 smes to ensure market exploitation 2 industrial companies and 1 water company
stedenabled superresolution multimodefibre based holographic endoscopy for deeptissue observations of neuronal connectivity

neurological disorders have emerged as a significant global societal burden exemplified by afflictions like alzheimers and parkinsons impacting over one billion individuals globally and surpassing the combined economic burden of cancer and diabetes this has spurred a concerted global effort with increased support for neuroscience research these disorders often target deep brain regions and profoundly influence the structural connectivity of neuronal cells within functional circuits synapses where neurons exchange information exhibit plasticity altering information transmission efficiency shape and position understanding the mechanisms underlying these structural changes especially in neuronal circuits remains limited in both healthy and affected individuals the erc poc project stedgate seeks to advance our understanding of neuronal connectivity and plasticity by developing stedenabled holographic endonanoscopy for neuroscience this groundbreaking technology promises atraumatic nanoscale invivo imaging of deep brain structures reaching depths up to 5 mm beneath the brains surface collaborating with the startup endeavour deepen the team aims to facilitate the commercial transition of this technology making deeptisue nanoscopy available globally will revolutionize our ability to monitor and understand neurological disorders and ultimately offer new avenues for intervention and treatment
interconnecting 4 helix innovation ecosystems in european regions

focused on challengedriven promotion of healthy living integer will bring forward three important innovations for the development of more robust sustainable inclusive and integrative eu innovation ecosystems 1the integer 4 helix collaboratory model to implement the next generation of living labs the collaboratories 2a eu healthy living collaboratory a true network of networks community with capacity to work on real social tech and businessdriven projects and 3 a new professional profile the collaber or collaboratory manager as a multiplying agent of change of these integrated innovation ecosystems the 3 integer reinforcing innovations will push fivefold breakthrough capacities for the integration of social innovation in eu innovation ecosystems 1boost winwin games between business and social oriented innovations addressing common challenges 2transform cocreation dynamics into disruptive and tangible new products services or competencies 3codesign jointly public innovation policies 4develop capacity building of the new generation of sociodigital entrepreneurs and ecosystems enablers the collabers and 5devise funding and investment mechanisms for social innovation startups and smes to develop and scale up game changing innovations collaboratories and collabers aim to embrace economic and socialdriven innovation communities across eu as novel 3h and 4h socialbusiness innovation integration structures these labs without walls are becoming the common open house of all kinds of innovators and entrepreneurs interested in producing new products and services that come from business or social oriented innovation based on a peertopeer approach between businessdriven and socialdriven innovations integer seeks to accelerate transformative integration outcomes by creating new winwin games local missiondriven synergies groundbreaking coordination of actions governance implementation uptaking and exploitation dynamics
social cognition in 22qll2 schizophrenia mouse model role of mpfc dysfunction and oxytocin

schizophrenia is associated with impairment of social cognition and social function medial prefrontal cortex mpfc is crucial for processing of social cues and regulation of social behaviour altered connectivity within mpfc in schizophrenia patients compared to healthy controls could explain patients poorer ability to differentiate between individuals and impairment to emotion recognition 22q112 deletion syndrome is one of the largest know genetic risk factors for developing schizophrenia and is associated with impairments to social recognition and emotion processing however the changes to mpfc neurocircuitry in 22q112 causing the social cognition deficits remain poorly understood oxytocin oxt is pivotal to social recognition and social function inactivation of mpfc oxt receptors impairs social recognition in mice comparable to social cognition deficits in schizophrenia the 22q112 deletion mouse model lgdel displays impairments to social memory and emotion recognition and mice display altered mpfc neuronal activity patterns during cognitive tests and brain oxt levels are lower in lgdel compared to wild type mice these findings suggest that social cognitive deficits in schizophrenia could be caused by disruption to mpfc neurocircuitry possibly mediated by altered oxt availability or by oxt modulation of dopamine within mpfc using a combination of cutting edge electrophysiological recordings and measurement of oxt and dopamine realtime dynamics during a battery of nonsocial and social cognitive tests i aim to deliver detailed information about neuronal activity and synchrony throughout the mpfc in during social cognition tests in wt and lgdel mice this will provide insight into the microcircuitry underlying changes to neurofunction and cognition in schizophrenia cause impairments which could aid the improvement of treatment of social cognition deficits in schizophrenia
phagosomal lc3s alternative role

the opportunistic fungus aspergillus fumigatus is an emerging cause of lifethreatening respiratory infections in an expanding group of patients with acquired innate immune defects dissecting the molecular dynamics of fungalhost interplay mediating sterilizing immunity against a fumigatus is crucial to gain insight in disease pathogenesis and develop novel immunomodulatory therapies physiologically aspergillus fumigatus conidia are eliminated inside alveolar macrophages ams via activation of the lc3 associated phagocytosis lap pathway a fumigatus cell wall melanin blocks lap to promote pathogenicity intracellular germination of a fumigatus conidia results in exposure of immunostimulatory fungal molecules concomitantly with melanin removal and triggers nadph oxidasedependent activation of lap the molecular mechanism of lc3 conjugation on a fumigatus phagosome membrane and the physiological function of lap on am biology and antifungal host defense remain elusive of interest pilot studies in the host lab demonstrate that infection of ams and other types of macrophages with live conidia of a fumigatus results in a unique pattern of pulsatile lc3 recruitment on the phagosome membrane which is accompanied by waves of increased phagosome permeability these findings imply for a novel mechanism of lc3 phagosome laposome formation via cytosolic sensing of fungal vitapamps and suggests for an unconventional function of laposomes in regulation of membrane repair mechanisms in response to damage induced by aspergillus infection this research project aims to understand the precise host and pathogen molecular determinants of laposome formation and exploit the intriguing role of lc3 on regulation of phagosomal membrane repair during a fumigatus infection using a fumigatus as a model pathogen this project with provide fundamental insights on the role of lap in macrophage biology paving the way for new hostdirected strategies
extremely highspeed laser processes for sustainable and flexible manufacturing

recent events such as the covid pandemic and the ukraine war have increased global uncertainty and prompted european companies to rethink their global supply chain and production methods given the unpredictable nature of potential shocks it is crucial for european industry to maintain a high degree of flexibility and adaptability in order to swiftly respond to sudden changes whenever they may occurthe laserway project aims to revolutionize the manufacturing industry by replacing conventional inefficient and environmentally harmful methods with highly flexible production lines based on highspeed laser technology laser blanking laser microdrilling and extreme highspeed laser material deposition ehla are the three laser manufacturing technologies selected for their potential to create more sustainable manufacturing processes and productsthe project focuses on developing wayfaster machines to improve the performance of the laser technologies through lightweight designs vibration control techniques and program optimizations tailored for highspeed laser applications wayfaster photonics aims to ensure precise delivery of the laser beam at extreme speeds targeting three laser technologies with unique demands the waystronger integration concept aims to enhance the sustainability resilience and flexibility of current manufacturing processes by integrating new technologies mechanically and digitallythe projects success will provide a competitive edge for industries such as automotive and aerospace by reducing processing times improving material usage and enhancing endproduct quality the advancements made through the laserway project will drive innovation in highspeed laser processing solidifying europes position as a global leader in advanced manufacturing technologies