Dragon09/odtu_chatbot huggingface dataset:
2d nano hybrid systems interfacing biomolecular motors with nanopores in 2d materials

interfacing the solidstate electronics with biological systems has been a longstanding challenge in nanobiotechnology creating nanobio hybrids would enable harnessing the remarkable capabilities offered by solidstate materials and biological molecules such as proteins enzymes dna etc at the same time twodimensional 2d materials are among the most prospective building blocks for futuregeneration electronic and biosensing devices due to their exceptional optoelectronic and mechanical properties combined with their atomic thickness their ultimate thinness has been considered as a remarkable advantage for nanoporebased sensing and they have been widely investigated as 2d solidstate nanopore platforms for singlemolecule sensing the goal of this proposal is to push further the development of 2d nanopores by developing new protocols for creating interfaces between 2d materials and biomolecular motors attaching the enzyme motor such as dna helicase to a nanopore made in 2d material would introduce an active control in nanofluidic transport of singlemolecules and ions such hybrid platforms presents a step forward in uniting biological inspiration and nanoscale engineering offering unprecedented levels of control precision and versatility at the nanoscale the future direction holds promise across a wide spectrum of applications from fundamental scientific research to transformative technologies that could impact fields as diverse as nanobiotechnology personalized medicine and diagnostics environmental sensing nanorobotics and many more
making migrant voices heard through literature how collaboration is changing the cultural field

as initiatives for more diversity and inclusiveness in the cultural field are gaining ground and migration becomes an increasingly important issue on the political agendas of many countries around the world this project examines the ways in which transnational collaborations create spaces for literary participation of migrants situated at the intersection between international relations comparative literature and business economics collab analyzes the notion of collaboration from a threefold perspective 1 as a political strategy in civil society that enhances intercultural exchange and the social integration of migrants through collective storytelling 2 as a form of coauthorship between migrants and other writers with different cultural backgrounds that gives voice to stories of migration that would often be lost without their translation 3 as an alternative economic model consisting in peertopeer support that brings new voices to the publishing industry focusing on a broad range of nonprofit organizations collaborative texts by amateur and professional writers and crowdfunding platforms that help make migrant voices heard through literature the project seeks to understand how collaboration changes the cultural field and impinges on migrants agency it shows how social actors and institutions that are traditionally perceived as belonging outside the cultural field have become crucial players in redefining notions of authorship rooted in individual and national singularity challenging strict distinctions between textual and contextual dynamics collab highlights the social embeddedness of literature and builds an original framework for understanding the thematic and formal implications of transnational collaboration in literary texts while borrowing theories and methods from other disciplines collab confidently reorients the social sciences towards the projects center of gravity the literary text and shows that literature is an important tool to understand broader societal transformations
immunestromal crosstalk in inflammation and fibrosis exploiting the spatiotemporal dynamics of the osmosmr axis in inflammatory bowel disease to develop novel antifibrotic therapies

intestinal fibrosis is a common and serious complication of inflammatory bowel disease ibd while intestinal inflammation can be treated pharmacologically based on our current understanding of the underlying pathogenesis little is known about the mechanisms driving fibrogenesis thus no approved therapies exist for intestinal fibrosis while stromal cells lie at the heart of fibrogenesis our knowledge of how immunederived signals instruct aberrant tissue repair and fibrosis is limited we recently highlighted that the immunestromal cell axis is a crucial component of ibd pathogenesis our research discovered that the il6 family cytokine oncostatinm osm plays a central role in immunestromal crosstalk in human ibd and drives proinflammatory responses in patients with refractory disease genetic deletion of osm significantly reduced acute intestinal inflammation furthermore our current findings suggest that osm is required for intestinal remodeling and the regulation of collagen homeostasis by controlling immune cell recruitment thus the osmosmr axis serves as a rheostat for tissue inflammation and repair we will investigate how osm modulates intestinal fibrosis and identify upstream and downstream signaling events controlling intestinal fibrosis i will use i newly generated reporter and conditional knockout mice ii contemporary mouse models of intestinal inflammation and fibrosis iii primary human tissue samples from carefully clinically annotated ibd patients with intestinal fibrosis and iv cuttingedge technologies including singlecell sequencing and imaging mass cytometry to dissect the crosstalk between the immune system and stromal cells driving intestinal fibrosis this project will deepen our understanding of the intestinal aberrant tissue repair mechanisms acting in ibd and other fibrotic diseases define novel biomarkers to identify patients at risk of fibrosis and provide the means to prevent and treat fibrotic disease
creating legitimate emission factors for verified ghg emission reductions in transport

clever aims to overcome barriers by developing new harmonised ghg emission factors for transport sector freight passenger encompassing uncovered categories new and conventional fuels and production paths while taking up the full energy lifecycle welltowheelwake and providing clearer guides for calculating and accounting emission factors covering ghg emissions co2eq of the entire transport chain in all modes clever framework ensures consistent calculation of new energy carriers remaining effective as the industry evolves and emission calculation method for accurate quantified and accounted emissions ensuring policy and business relevance clever applies multiactor approach engaging global stakeholders through a codesign cocreation and coassessment process clever reviews existing emission factors derived from global sources aligned with scientific advances and gaps identification the framework is a concise guide created upon recommended input parameters fuelenergy specifications and assumptions it ensures a understanding and proper application of consequential and attributional methods b clear boundaries calculation to avoid biases aligning data labels and values for consistent emission factors and c document how fuelbased emission factors feed into default emission intensities considering operational parameters and integration in databases the framework contains a new harmonised ghg emission factors b common rules for calculating climate impact and c decision tree based on these rules this guide helps stakeholders making informed ghg emissions calculations and mitigates conflicting approaches the framework undergoes validation in different industrial uses through personalised coaching for enhancing market uptake regulatory engagement certification standardization iso14083 review and training are planned greater consistency and reliability of ghg calculation leads to transport decarbonization supporting eu goals
future proof efficient and sustainable deployment of zewt

trustee project aims at supporting the european roadmap to deploy the zewt providing the decision makers and the wide stakeholders community with a comprehensive and sciencebased set of knowledge and recommendations built on an evidence based approach founded on clarity and comprehensiveness of foresight scenarios in 2030 and 2050 where zewt will be deployed a comparative multidimensional assessment framework incorporating environmental social technological financial and operational aspects including safety and security aspects for workforce and citizens a robust validation roadmap with an equitable representation of direct and indirect stakeholderstrustee is built on the following objectives define and validate future european zewt wide ecosystem at 2030 and 2050 time horizons through foresight scenarios detail and validate the most promising zewt use cases for the 2030 and 2050 target horizons build and validate a multistakeholders and crosssectorial assessment framework for system components and overall ecosystems underpinning the zero emissions target in the european water transport sector identify systemic and sectorial barriers challenging the zwet targets and defining recommendations for its timely deployment create a common knowledge background among all direct and indirect stakeholders for zewt targets timely achievement thanks to a consortium with relevant expertise and strong institutional liaison with all the zewt stakeholders trustee will achieve the desired impact delivering actionable open access results zewt 2030 and 2050 foresight scenarios zewt technology readiness review comparative analysis framework for zewt use cases assessment combining environmental technical integration operational societal and financial indicators zewt barrier analysis most promising zewt use cases recommendations for zewt standards regulations and policy development zewt open access learning pack
synergizing neural network theory and combinatorial optimization via extension complexity

artificial intelligence is changing our lives artificial neural networks are present and entering various fields of modern technology such as medicine engineering education and many more even a smallscale theoretical understanding of why and how neural networks succeed in practice can have a considerable impact on the future development of such technologiesin contrast combinatorial optimization is a wellestablished discipline at the intersection of mathematics and computer science dealing with classical algorithmic questions like the shortest path or traveling salesperson problems a powerful tool to study structural and algorithmic properties of combinatorial optimization problems is polyhedral geometry for example the geometric notion of extension complexity classifies how well a specific problem can be expressed and solved via an extremely successful generalpurpose technique called linear programmingrecent developments show that polyhedral theory can also be a powerful tool to achieve a better mathematical understanding of neural networks the overall goal of this project is to significantly intensify the connection between neural networks and polyhedral theory using the concept of extension complexity this new symbiosis will advance both the theoretical understanding of neural networks as well as the fundamental understanding of classical combinatorial optimization problems on the side of neural networks we expect to obtain new bounds on the required size and depth to solve a given problem serving as an explanation of why large and deep neural networks are more successful in practice furthermore we expect contributions to a more refined understanding of the computational complexity to train a neural network on the side of combinatorial optimization we expect that generalized notions of extension complexity inspired by neural networks lead to new structural and algorithmic insights to classical problems like the matching problem
nanoplastic transport in groundwater environments

groundwater is the largest drinking water resource on earth and 75 of eu residents depend on groundwater as water supply plastic contamination of drinking water supply wells has recently been documented plastic particles are a vector for pollutants interfere with biogeochemical cycles and nutrient transport while particular nanoplastic np is shown to cause adverse effects on human health hence drinking water contamination by np is a serious threat to human health to protect the earths largest freshwater reservoir and guarantee a sustainable use of water resources within europe for future generations we need to understand np behavior in groundwater aquifers in this mscaction i will study the transport behavior of np particles in complex mineral and biogeochemical groundwater settings from lab to field scale in order to embrace the natural complexity of aquifers the following msca objectives address four major knowledge gaps of np transport in groundwater systems ihow does np shape affect transport in groundwater iican flow rates modify np transport in complex mineral and biogeochemical porous media settingsiiiare fungal communities able to retain np under realistic aquifer conditions ivcan findings from laboratory studies be upscaled to field scale studies i will answer these objectives by conducting laboratory experiments combining nanotechnological methods with novel microfluidic chips as well as field scale experiments using a tracer injection method with these approaches we generate tracer breakthrough curves inferring sediment specific retention rates while they also enable us to gain better mechanistic understanding of np transpor in porous media this msca will be a steppingstone in understanding np transport in groundwater environments more systematically such knowledge will inform the development of new environmental models to enhance the predictive capability of np pollution in drinking water reservoirs
circular systemic waterenergyfoodecosystems wefe nexus ccri demonstrator for regions facing severe water stress

contributing to the ccri project portfolio ciswefenex will demonstrate the implementation of a circular systemic wefe nexus an innovative fully integrated sustainable approach applying the principles of circular economy for closing loops in the key value chains of food water nutrients in severely water stressed regions1 water a net positive freshwater balance to the water cycle jrc 2021 will be achieved through combining olive mill wastewater reuse as a coproduct from biophenols extraction with saltwater desalination at scale without using fossil fuels for use as drinking irrigation water waste streams from desalination brine bitterns will be repurposed in naturebased solar saltworks as table epsom salt made possible because of zero chemical use in the desalination process2 energy cuttingedge renewable energy technologies will be developed demonstrated to achieve a netzero direct fossil ghg emissions process agriphotovoltaics crops under pv panels and biogas from advanced ultrasonic cavitation assisted anaerobic digestion fed from olive mill other biowastes3 food innovative naturebased techniques will be demonstrated to enable truly sustainable healthy and fresh food seaweed containing bioactive compounds for pharma use production at scale saltwater integrated multitrophic aquaculture free of growth hormones antibiotics synthetic fertilisers preservatives regenerative agriculture organic permaculture reusing precious water nutrients and extractive reuse of biophenols from olive mill waste as bioactive products of very high nutripharmaceutical value4 ecosystems monitoring of traditional emerging micropollutants using cuttingedge analytics will prevent harmful impacts on the environment food grown from it with predictive alerts remedies through a mobile controlled cavitation unit providing wastewater treatment services advanced oxidation processes disinfection
expanding concept and methodology for human past studies in the eastern baltics countries

echo consolidates the existing academic excellence and creates new synergies in the eastern baltics by bringing together humanitarian scholars archaeologists historians natural scientists geneticists bioinformaticians and experts from the intersection of those disciplines anthropologists from the region to enhance and promote research in the human past within the interdisciplinary framework the motivation of the echo is to understand the processes behind the current diversity of peoples and cultures the role and mutual interaction of demographic developments and environmental changes in those processes and to share this knowledge with societythe echos paneastern baltic network of archaeogenomic research will link the resources of the three baltic countries estonia latvia and lithuania to conduct internationally competitive research on the human past within echo the knowledge of stateoftheart analytical tools and interdisciplinary project and data management skills transferred from advanced eu partners will be tested for addressing timely questions about the human past with the focus on currently understudied local evolutionary developments during the postbronze age period in the eastern baltic regionthe synergistic science conducted within echo will help to increase the visibility of the research done in the eastern baltic region on the human past at both european and global scales and to contribute to the common knowledge about the processes that have shaped the present diversity of human populations in the eastern baltic region in the spatiotemporal context of europe echo will contribute to sustainable interdisciplinary research on archaeogenomics in the eastern baltics supported by the consolidated network of regional research centres enhanced concepts and enriched methodology
from immigrants to colonialists italians in egypt and the others fragments of subaltern agency in a colonial sea 1861 1911

what was the shared experience of global cities in the southern and eastern mediterranean during the second half of the 19th century how did the subaltern classes experience the processes of modernization and colonialism the aim of subcolonialmed is to offer new insights into sociohistorical questions regarding the link between migrations and colonialism in the late 19th early 20th centuries the project is based on the italian migration to egypt but seeks to broaden its analysis to encompass the entire mediterranean italian diaspora it examines the hypothesis that italian colonies in the mediterranean region were pivotal to the foreign and colonial policy of the kingdom of italy contributing significantly to the shaping of national identity i argue that even before the occupation of lybia the communities in territories subject to the capitulations legal system served as laboratories for the construction of italians as national and white political subjects however it is a mistake to perceive a direct correlation between metropolitan colonial politics and mass migrations operating under the assumption that social transformations arise from global and local processes this research regards migration as a socialhistorical phenomenon involving specific and autonomous dynamics of appropriation hybridization and rejection methodologically it strives to break new ground by proposing a interdisciplinary study with three components consular archives judicial documents and qualitative biographical data all used to explore these connections combining the micro historical approach with postcolonial theories and intersectional method the project want to test how italian subalterns in egypt appropriated nationality becoming colonial actors the goal is to arrive to fundamental new insights about the interethnic relations of ordinary people in the cosmopolitan cities of egypt and in the rest of the region
photopatternable electrolytes for solidstate organic electrochemical neurons

future advanced braincomputer interfaces wearable and implantable bioelectronic devices prosthetics and intelligent soft robotics will require the ability to process signals in a highly personalized and localized manner which will involve fully integrated electronic circuits within the nervous system and other living tissues to achieve this goal it is imperative to develop energyefficient intelligent electronics that have minimal devicecircuit complexity and ionbased transducing and operating mechanisms akin to those observed in biology the use of siliconbased devices and circuits presents several limitations organic electrochemical transistors oects represent a rapidly advancing technology that plays a pivotal role in the development of nextgeneration bioelectronic devices however a notable limitation of oects is their typical operation in aqueous electrolytes which can lead to undesired crosstalk between different devices on the same substrate impeding their seamless integration into largearea arrays therefore it is hard to develop neural networks based on the current oects solid electrolytes offer a promising solution to these challenges in this proposal i design a photopatternable solid electrolyte to develop solidstate oects the aim is to directly pattern the electrolyte using sequential ultraviolet lighttriggered solubility modulation we plan to use uvsensitive pegda to directly pattern the hydrogel without requiring photoresist or liftoff processes the pegda network will be covalently crosslinked after uv exposure to form a hydrogel network the strong intermolecular interaction between the two networks will allow the uvexposed regions to resist subsequent water development while the uvunexposed regions will remain watersoluble this approach will enable the creation of smallersize largearea processing oect devices ultimately facilitating the development of oecns with sizes approaching that of biological neurons
indoor photovoltaics towards an energy and climateneutral world

the mentor research initiative will provide a comprehensive and versatile technical platform for the development of nextgeneration indoor photovoltaics ipvs that efficiently reuse energy from artificial illumination to power electronics eventually contributing to an energy and climateneutral future mentor aims to unlock the full potential of ipvs taking into consideration growing concerns about sustainability through the establishment of the first international network of 8 universities 7 industrial partners and 5 research centers the consortium will cover all the key aspects and technologies related to ipvs including sustainable design organic and inorganic materials synthesis photovoltaics manufacturing and characterization device physics and modelling theoretical and machine learningdriven approaches photovoltaics recycling and industrial processing mentor will establish an interdisciplinary intersectoral and global program of doctoral training and research that propels the development of new leaders capable of directing academic and industrial rd on renewable energy electronics and sustainability through the successful implementation of 16 doctoral candidate dc individual projects this research initiative will amplify the recently recognized importance of ipvs for the sustainable powering of the iot by advancing novel material designs processing methods device architectures theoretical models and characterization standards across disciplines and sectors