Dragon09/odtu_chatbot huggingface dataset:
mainstreaming integrated assessment models by embedding behavioural change and actor heterogeneity and increasing their outreach to citizens communities and industrial actors

the integrated assessment models iams are an invaluable instrument for modelling climate stabilization pathways and for supporting the policy makers in taking better informed decisions nevertheless the mitigation options traditionally focused on in iams are the supplyside measures whereas less attention used to be paid to demandside and food system representation due to the inherent complexity and actor heterogeneity choice aspires to mainstream iams embedding them into the lifestyle choices and decision making process of consumers producers and actors of the food agriculture and land use sectors this ambition is leveraged by a more realistic representation of behaviour change and actor heterogeneity aspects in iams and supported by an approach that bridges social science and marketing tools with the aim of accelerating climate action this approach will be supported by the largescale adoption of choice digital immersive tools data storytelling and gamification whose design is underpinned by notions of emotional appeals and social incentives using these digital enablers choice will orchestrate large scale engagement and green marketing campaigns that have a wide geographical and societal dispersity thus starting from a bottomup analysis of individual consumers and actors of the food supply chain and understanding their behavior and their potential for change choice will use this information in order to consistently feed into a new generation of iam models that will correctly reflect the underlying heterogeneity accounting for multiple representative consumers and actors the iamgenerated impacts from highly influential 15occompatible mitigation actions shall highlight besides emissions the cobenefits of their changes in behaviour or practice in terms of health biodiversity and food security aspects in familiar scales
incitedem inclusive citizenship in a world in transformation codesigning for democracy

incitedems experienced consortium aims to enhance inclusive participation and civic engagement while expanding democratic innovation and dynamic feedback mechanisms between citizens and institutional actors in representative democracies currently wicked problems relating to ecological crises but also media developments and digital divides create unprecedented pressures on democracies next to related socioeconomic challenges were witnessing a decline in political trust and the formation of new societal cleavages incitedem will offer a unique contribution to the future of democracy in europe by harnessing historical and quantitative and qualitative social science research agentbased modelling design thinking and advanced analytical methods for the purpose of expanding inclusive participation and engagement and fuelling democratic innovation furthermore we will implement democracy labs dlabs in six countries where citizens representatives of democratic innovation initiatives policymakers and other stakeholders come together to cocreate imaginaries of inclusive democratic innovations the new solutions and democratic futures envisioned are the objects of design fiction products all innovations cocreated in the dlabs are then validated through a choice experiment survey with citizens and interactive fora with policymakers to check their feasibility and the potential for implementation lastly a set of policy roadmaps for a sustainable inclusive and innovative democracy in a world facing deep societal technological and ecological transformations are produced and presented to a broad range of stakeholders at multiple levels of governance in europe
light for controlling reactive interactions in cold molecules

ultracold molecules are the next frontier of quantum technologies their rich internal structure and tunable longrange interactions enable the exploration of new regimes unattainable with atomic platforms achieving this control requires cooling to ultracold temperatures however ultracold molecular interactions are dominated by lossy chemical reactions chemical reactions hamper the quantum applications of molecular gases and our strategies to reach the ultracold temperature limit including the realization of the holy grail of ultracold molecular physics a boseeinstein condensate of polar molecules recently i successfully developed several shielding mechanisms to protect polar molecules from chemical reactions and exploited them to realize the first quantum degenerate fermi gas of molecules by direct evaporation in lirico i will leverage on these previous results to control the chemical reactions of ultracold molecules and thus unlock the full potential of molecular quantum gases a highfinesse optical cavity will be the fulcrum of lirico to tame chemical reactions strong lightmolecule coupling will create new hybrid lightmolecule states so called molecular polaritons that will display the ability to turn onandoff a chemical reaction by simply controlling the moleculecavity resonance the addition of finalstate sensitive detection methods such as an ionmass spectrometer will allow to fully resolve the microscopic mechanisms that underpin ultracold reactions i will steer the reaction dynamics at will and control the reaction product distribution with the cavity vacuum thus realizing a paradigmchanging fully quantummechanical catalysis method for controlling the transformation of molecular materials cavitycontrol of ultracold chemical reactions will open new avenues in the dissipation engineering of inelastic and outofequilibrium processes which is crucial for the development of molecular quantum technologies
hide and seek exploring pfas accumulated in urban sludge

per and polyfluoroalkyl substances pfas threats to human health as forever chemicals and a key issue addressed by the european commission urban sludge in wastewater treatment plants has become a sink from pfas the final end of the pipe however the accumulation process of pfas in urban sludge and the intricate interplay between pfas and sludge components are still unknown here the hasps project aims to comprehensively investigate the binding of pfas with various structural features to individual eps components such as proteins polysaccharides humic acids and nucleic acids a task previously unexplored to achieve this we will comprehensively characterize the eps present in sludge samples from different countries such as denmark and singapore and its importance on pfas adsorption in sludge a new extraction method for each eps component will be established through a combination of physical and chemical treatments further we will unveil the interaction mechanism between each eps component and pfas with diffident chains and functional groups using extracted eps and model eps components a novel adsorption mechanism approach will be established based on spectroscopy mass spectrometry surfactant techniques and computational models this new knowledge of exploring pfas accumulated in sludge is essential for implementing effective pollution control strategies to minimize the entry of pfas into the environment with this project i am aiming to combine my background in organic pollutant control with the distinguished expertise of the host research group focusing on pfas and eps in sludge at aarhus university
model atmospheres of the progenitor stars to supernovae and black holes finally in 3d

stars with masses many times that of our sun are the direct progenitors to cosmic phenomena such as supernova explosions black holes and gravitational wave gw sources through electromagnetic observations we obtain empirical information of such massive stars however decoding the radiation reaching us through our telescopes is a highly nontrivial exercise to constrain fundamental properties like temperatures radii chemical abundances and mass loss the observed radiation is fit by means of model stellar atmospheres observations and theory show that the radiationdominated atmospheres of massive stars are highly complex multidimensional systems however although 3d model atmospheres of sunlike stars have already been on the market for a while for hot massive stars we still rely solely on results derived from inadequate 1d simulations this severely limits our knowledge of the basic physics of massive stars and our capacity to correctly interpret observations thereby preventing progress also in the large number of astronomical fields eg black hole and gw progenitor models that rely on a firm understanding of the massivestar lifecycle the time is now ripe to change thisbuilding on the unique expertise of the pi and his team in a groundbreaking effort we will here develop the very first 3d model atmospheres for hot massive stars with winds superstars3d will fundamentally improve our physical understanding of massive stars and revolutionize analysis and interpretation of their observed radiation by further confronting our pioneering simulations directly to stateoftheart observations we will derive unprecedented constraints on evolution and endoflife models we will develop all new models in an opensource fashion and make them easily accessible for a broad community as such superstars3d will also provide the critical cornerstone from which a large number of future scientific programs undoubtedly will be built
rnabased cancer immunotherapeutics to enhance crossprimming

cancer immunotherapy achieves unprecedented efficacy against a number of malignant diseases preclinical experiments in mouse models conclude that type1 dendritic cells cdc1 that present tumor antigens are an absolute requirement for most immunotherapy strategies to be efficacious including those routinely applied to cancer patients at present cdc1 cells are specialized in redirecting engulfed cellassociated antigens to the class i mhc antigenpresentation pathway in the context of il12 production and costimulation at least when cdc1 cells are in the presence of moieties denoting viral infection such phenomena are key to prime antitumor t lymphocytes through a mechanism known as crosspriming the ripecrop project will test immunotherapy agents that enhance the numbers and performance of cdc1 in the tumor tissue microenvironment the strategies will be based on mrna constructs that will encode engineered forms of the cdc1 growth factor sflt3l singlechain interleukin12 cdc1 specific chemoattractants and bispecific costimulatory ligands targeted to surface proteins of cdc1 cells the new therapeutic agents in the form of coding mrnas will be expressed in vivo either intratumorally or using the mrnatransferred liver as an internal biofactory to systemically produce the encoded proteins and their combinations innovative invivo screenings based on hydrodynamic gene transfer of the liver with various expression plasmids encoding heterodimerization systems will be performed to identify suitable new mrnabased immunotherapeutic chimeric constructs to enhance antitumor tcell crosspriming overall a novel mrnabased toolbox will be studied both in terms of antitumor efficacy and regarding the mechanisms of action in such a manner that crosspriming will become exploitable in combinatorial approaches for cancer immunotherapy
in situ structural basis of human axonopathies

myelinated axons propagate action potentials across otherwise unsurmountable distances the overarching hypothesis of the cryonerve project is that membrane morphology crucially determines axonal health and function mutations in genes coding for membraneshaping proteins are the major cause of familial axonopathies like hereditary spastic paraplegia hsp and charcotmarietooth cmt disease however current techniques lack the resolution to ascertain the functions of these proteins and their pathological dysfunction within native nerves at the same time the highly specialized architecture of axons and their delicate interplay with glia can only be studied in situi have shown how cryoelectron tomography cryoet reveals the structural basis of neuronal function and disease within intact cells however cryoet imaging of tissues remains a major challenge in cryonerve we will develop cryoet workflows to image native nerve tissue at unprecedented resolution we will build on these advances to study the function of hsp and cmt proteins within truly physiological environments specifically we will investigate i how these proteins shape axonal organelles and their crosstalk ii the mechanisms allowing myelin sheath formation and neuronglia communication and iii the alterations introduced by axonopathycausing mutantslastly we will pioneer the first cryoet analyses of vitrified human tissues frustratingly peripheral nerve biopsies from axonopathy patients often cannot be diagnosed with existing methods we will examine patient biopsies at molecular resolution and capitalize on our findings in flies and mice to reveal hitherto obscured pathological abnormalities thus cryonerve will provide a holistic molecular and structural basis of human axonopathies like hsp and cmt pave the way for highresolution analyses of native human tissues and explore the potential of cryoet as a diagnostic tool with nanometric precision
revival of the powerhouse how mitochondrial remodelling controls the energy metabolism of the malaria parasite to enable survival in different hosts

the mitochondrion of the malaria agent plasmodium falciparum is critical for parasite survival and a confirmed drug target the dynamic organelle undergoes a plasmodiumspecific membrane remodelling process to adapt to changing metabolic conditions in different hosts this remarkable transformation is thought to be driven by the arrangement of divergent atp synthase and respiratory chain complexes into supramolecular assemblies which shape the internal cristae membranes however the structures of both oxidative phosphorylation oxphos protein complexes and the underlying molecular mechanism are unknown having recently pioneered parasite oxphos complex structure determination i will tackle this longstanding enigma by combining stateoftheart parasitology highresolution and in situ structural techniques and functional analysis to reconstruct a stageresolved molecular model of the parasites bioenergetic membrane and reveal the mechanism of membrane remodellingin aim 1 we will adapt cuttingedge cultivation methods to unlock structural studies of p falciparum oxphos complexes by generating enough sexualstage mitochondria to perform electron cryotomography and visualize the reorganisation of the inner membrane in situin aim 2 we will develop a stageresolved molecular model of the p falciparum inner membrane and reveal its architecture by determining highresolution cryoem structures of both oxphos complexes investigating their membraneshaping properties and revealing binding mechanisms of investigational cytochromeb inhibitors to inform antimalarial drug discoveryin aim 3 we draw on new structural insights to perform functional characterisation in parasites and understand the role of parasitespecific subunits in mitochondrial remodelling energy conversion and parasite fitnessthis integrated approach will deliver novel insights into the plasticity and smallmolecule modulation of mitochondrial energy metabolism in malaria parasites
implementing primaquine single low dose in africa

the 2021 world malaria report estimates that the number of clinical cases in 2020 was 241 million and the number of deaths was 627000 an increase of 69000 compared to 2019 a timely reminder to maintain good malaria control and introduce novel elimination strategies in 2012 to further reduce malaria transmission and possibly reach elimination the who recommended adding single low dose primaquine sldpq to artemisinin based treatments acts in low transmission settings and more recently in areas where artemisinin resistance is emerging sldpq kills mature gametocytes blocking the transmission between humans and mosquitoes and should see a reduction in the malaria burden with widespread deployment compounding the poor uptake of sldpq is the lack of childfriendly formulations of primaquine and lingering anxieties regarding primaquinerelated acute haemolysis in patients with glucose6phosphate dehydrogenase deficiency building on the good progress of the developing paediatric primaquine edctp2funded project aiming at prequalifying paediatric formulations we have conceived the imprima project to support the adoption of sldpq by conducting a reallife implementation study using our flavoured primaquine for children key to our success is the unique triangle of interconnecting activities clinical communitysociological and policy all within a matrix of capacity building and strong coordination by all seven partners our ambitious proposal aims to demonstrate the safety acceptability and community benefit of sldpq in 3 african countries with different malaria epidemiologies engagement with the communities and policy makers are fundamental to effect a positive change in drug policy and contribute to malaria elimination in parallel capacity will be enhanced for conducting clinical trials and monitoring the evolution of antimalarial drugs resistance we believe the imprima project fits extremely well with the priorities of this call
boosting excellence in environmental epigenetics

the epiboost project joins a widening partner and two internationallyleading partners that will steer a solid capacitation strategy towards tackling the challenges to the recently proposed uptake of epigenomics by environmental assessment frameworks capacitation activities cover for 5 specific objectives the 1st is to optimize research protocols enhancing the practical skills and research profile of the widening partner for the development of excellent science in the field of environmental epigenetics this constitutes the nurturing stage where we will be twinning exchanges and training sessions under an overall philosophy of learning and advancingbydoing allowed by a preparatory research project which will build knowledge on the suitability of dna methylation signatures as informative biomarkers of environmental contamination and effects the 2nd objective is focused on the seeding of the talent that will sustain the european critical mass at the best worldclass standards in the field through the organization of several training events advanced courses summer schools and short courses in scientific meetings targeting young eu researchers the 3rd and 4th objectives regard the absolute need of a capacitated science management and administrative support to effectively grow worldclass research in the field these will be tackled through an immersive training programme focusing key core facilities ethics animal housing sequencing managers exchange for onsite training professional training and realtime funding application preparation the fifth addresses network growing and will be achieved through a systematic strategy for involving international flagship experts in capacitation activities and stakeholders in the project which will strengthen the consortium for new research and innovation ventures
activate repair in stroke

the brain exhibits remarkable capacities to initiate selfrepair mechanisms after brain injury as a prerequisite for the recovery of lost functions arise will unveil fundamental yet not understood principles how brain repair mechanisms are orchestrated and how they can be further enhanced due to technical constraints it was previously impossible to uncover 1 how individual neurons rewire and reconnect after cns injury 2 why some surviving neurons participate in repair processes and others do not and 3 how neuronal rewiring could be further stimulated to promote the restoration of impaired functions but now with technological advances at hand i am in a unique position to tackle these major questions by examining causal relationships between neuronal rewiring and behavioral outcome i have recently developed a mouse model for vascular dementia that enables the monitoring of the same neurons in the hippocampus over several weeks under healthy conditions and after induction of multiple microstrokes in relation to the spatial memory of the animal using sophisticated closedloop experiments combining chronic 2photon imaging invivo with optogenetics and machine learning i will characterize neuronal recoding in relation to the behavioural performance of the animal i hypothesize that principles of learning are key to understand how surviving cells are recruited to participate in new neuronal ensembles to restore lost memory engrams using local light stimulation i will manipulate surviving neurons to unveil their role in rewiring network dynamics and repair processes and to enhance their engagement in restorative operations with arise i will establish a novel experimental pipeline to identify the cellular mechanisms of neuronal repair that are linked to distinct behavioural outcome parameters this approach will also allow me to train generalized linear models glms to assess the efficiency and predict the outcome of novel restorative therapies in stroke
robust automated driving in extreme weather

complex environment and traffic conditions have major impact on the safety and operations of connected and automated vehicles cavs weather affects not only the vehicle performance but also the roadway infrastructure thereby increases the risk of collision and traffic scenarios variations so far most automated vehicles have been primarily trained and tested under optimal weather and road conditions with clear visibility however the systems will have to prove that they are equally reliable and accurate under any weather and road condition before they can see widespread acceptance and adoption roadview integrates a complex invehicle systemofsystems able to perform advanced environment and traffic recognition and prediction and determine the appropriate course of action of a cav in a realworld environment including harsh weather conditions roadview develops an embedded invehicle perception and decisionmaking system based on enhanced sensing localisation and improved objectperson classification including vulnerable road users roadview groundbreaking innovations are grounded on a costeffective multisensory setup sensor noise modelling and filtering collaborative perception testing by simulationassisted methods and integration and demonstration under different scenarios and weather conditions reaching trl 7 by the end of the project roadview implements the coprogrammed european partnership connected cooperative and automated mobility ccam partnership by contributing to the development of a more powerful failsafe resilient and weatheraware technologies the consortium is a perfect combination of leading universities in the field and research institutes hightech smes and strong industry leaders beyond their research excellence the consortium members bring a unique portfolio of testing sites and testing infrastructure ranging from hardwaretesting facilities and rain and wind tunnels to test tracks north of the arctic circle