Dragon09/odtu_chatbot huggingface dataset:
spinmomentum locking and correlated phenomena in chiral topological materials

chiral topological semimetals are a new class of quantum materials at the intersection of structural and electronic chirality we discovered the first example of this material class three years ago and have since demonstrated that they host new fermionic quasiparticles without analogue in highenergy physics which carry large and controllable topological charges chiraltopmat will go beyond these initial works and aims to discover new extraordinary properties that have only been predicted for these materials but for which experimental evidence remains elusive 1 a new form of isotropic parallel spinmomentum locking that can be considered the natural counterpart of rashba spinorbit coupling 2 new electronic phases that are both correlated and topological and 3 interface effects with magnetic materials that could be exploited for new energyefficient information technology applications we will achieve these research goals by employing spin and angleresolved photoelectron spectroscopy on various energy scales probing these materials surface bulk and interface electronic structures whilst the proposed experiments are challenging our prior work and recent preliminary results have demonstrated their feasibility if successful chiraltopmat will build on these discoveries to search for structureproperty relationships that can be used to control these new phenomena by chemical and structural modification we envision that this new understanding will be the basis for future devices that exploit chiral topological semimetals for energyefficient magnetic memory devices which use multifold fermions for fieldfree switching of magnets with perpendicular magnetic anisotropy
targetting neutrophilmediated neurotoxicity for the treatment of alzheimers disease

with the neutrad erc poc project we present the first diseasemodifying alzheimers disease ad drugs that abrogate leukocytemediated neurotoxicity and represent a novel class of drugs in the treatment of adad is a neurological disorder characterized by progressive deterioration of cognitive function and leads to death within 39 years after diagnosis ad is highly prevalent in elderly and it is estimated that 35m patients suffer from the disease worldwide as a result ad has tremendous social and economic impact this is aggravated by the lack of diseasemodifying drugs as current therapies only provide shortterm symptomatic benefit hence novel therapeutic approaches are of critical importance to resolve this urgent and growing health crisis our novel antiad drug candidates use a neutrophiltargeted approach and unlock a novel avenue for the millions that suffer from ad growing evidence supports the role of inflammation in the development of neurodegeneration in ad for example our previous research has demonstrated a role for neutrophils in the induction of memory decline and neuropathological hallmarks of ad furthermore our data shows that a highly activated and degranulating neutrophil phenotype induces neurotoxicity in an in vitro ad context preliminary results have also demonstrated that our novel drug candidates rescue neuronal death and have diseasemodifying potential in adlike mouse modelsin neutrad we will explore the technical and commercial potential of our drug candidates as the first diseasemodifying drugs against ad specifically we will optimise and subsequently test the technical feasibility of our two drug candidates in adlike in vitro and in vivo models in parallel we will explore the commercial opportunity of our novel ad drugs and analyse the ip position and strategy as well as the market and existing and emerging competitors finally we will consolidate the project outcomes in an investorready business plan
designing longterm systemic transformation frameworks for regions accelerating the shift towards climate neutrality

the ambition of the transformer project is to design longterm systemic transformation frameworks for regions across europe in order to accelerate the shift towards climate neutrality at the onset of the project a conceptual framework will be developed by mapping defining and categorising transition superlabs tsls actual tsls will be piloted in four regions the ruhr area de emilia romagna it lower silesia pl and western macedonia gr the project will develop a roadmap blueprint a toolkit incl matchmaking mechanisms and a knowledge hub on the one hand to support the pilot regions but also to be applied by other regions across europe moreover an evaluation framework will be developed in order to evaluate the impact of tsls in the transformer pilot regions as well as the respective tools and structures applied by the pilot regions project activities will be accompanied by comprehensive communicate and disseminate activities providing intermediate results of the project and the activities in the pilot tsls providing a hub with information and offering training and capacity building activities for various target groups and stakeholders finally an exploitation plan will be prepared for a longlasting impact of the project
modification of liposomic nanocarriers a novel strategy for improved drugdelivery and eradication of bacterial biofilms

bacterial biofilms are widespread both as infections in humans and on devices that have come in contact with infected tissue and pose a major health and economic burden such biofilms are difficult to treat as they present strong resistance to drug delivery due to a dense hydrated polysaccharideprotein matrix in which the bacterial communities encase themselves and from the bacterial membrane itself liposomes stabilized by polyethylene glycol peg moieties the current goldstandard and most commonly used means of stabilization are versatile drugdelivery vehicles but such pegylation is associated with significant shortcomings greatly reducing the efficiency of pegylated liposomes for biofilm treatment here we explore a novel strategy to improve such drug delivery and treatment of biofilms in particular is it effective is it efficient can it be readily applied both in vitro for which we have some promising preliminary indications as for infected biomedical devices and crucially in vivo what is the ipr position for future exploitation of this new drug delivery strategy these questions illustrate the highriskhighgain nature of this proposal and are systematically addressed in this proposal through several interrelated work packages success of our project in demonstrating that our novel drugencapsulating vehicles can efficiently treat and eradicate bacterial biofilm infections would not only have benefits affecting large populations but also tap into a large drugdelivery market
immunometabolic regulation of microglia function in stroke recovery

stroke is one of the leading causes of death and disability worldwide despite recent improvements in stroke prevention and acute treatment there is still a very urgent need for promoting stroke recovery to improve patients quality of life microglia are the predominant brain resident immune cells in charge of brain homeostasis through immune surveillance emerging evidences suggest that poststroke microglial reactivity remains incompletely resolved and persists chronically immunomet aims to study the impact of persistent inflammatory and dysfunctional traits of microglia during stroke recovery through metabolic reprograming a set of essential processes key to satisfy the high energetic requirements of immune activation to fulfill this goal immunomet will use novel and cuttingedge methodologies including sophisticated imaging techniques multiparametric flow cytometry metabolomics and singlecell rna sequencing to investigate the time course evolution of microglia immunophenotype and the potential shifts in microglial metabolic pathways over the course of stroke immunomet will also evaluate the effects of an acute manipulation of microglia cellular metabolism on the stroke recovery as an approach to tackle chronic neuroinflammation and improve brain functional recovery after stroke to this end immunomet aims to assess microglia immunophenotype in two scenarios 1 a transgenic mouse line with altered microglia type i ifn signaling which may regulate energy metabolism and 2 after administering an itaconate derivate a modulator of immune cell polarization immunomet is expected to contribute novel and valuable insights into the immunometabolic adaptations to stroke this research will be a crucial for future development of therapies aimed at enhancing the longterm recovery of stroke survivors addressing a significant sociohealthcare challenge immunomet will be a major step in my academic career as an international independent researcher
overcoming the sign problem in lattice gauge theories using tensor networks

tensor networks and particularly projected entangled pair states peps are special quantum manybody states that describe stronglycorrelated systems well due to their entanglement structure they have been successfully applied in various scenarios and recently to lattice gauge theories lgts where they outperformed conventional montecarlo calculations and overcame the sign problem in some examples but mostly in singlespace dimensions due to limitations of tensor network methods a fundamental analogy between peps and gauge theories suggests that peps are suitable for studying lgts and that gauge symmetry often seen as complicating the numerics can help in overcoming the sign problem and perform efficient tensor network computations in higher dimensions the overarching goal of this project is to use this analogy in analytical and numerical ways aiming to 1 analytically devise a comprehensive new formalism for lgt peps and the physics they describe by allowing one to construct the optimal peps to be used as variational ansatz states when combined with numerical techniques 2 devise numerical methods for studying lgts with such peps thanks to the analogy based on sign problemfree variational montecarlo 3 apply these methods numerically to challenging nonperturbative models culminating in su3 in 31d with finite fermionic density towards quantum chromodynamics this is expected to overcome the sign problem of such models thus closing an important challenging and longstanding gap in the field of nonperturbative physics in general and gauge theories in particular the developed methods can be generalized for studying realtime dynamics of quantum field theories models of quantum gravity thermal quantum field theories and many other puzzling questions they will also advance the parallel contemporary approach to lgt quantum simulations and computations as some open problems are shared by both approaches
feedback between population dynamics and evolution of interactions in a tritrophic system

predicting ecosystems response to ongoing environmental shifts is a major challenge in ecology and evolution which is tightly linked with the ecoevolutionary feedback loop however we lack studies that thoroughly examine the whole loop of ecology to evolution and back moreover there is a dire need for comprehensive studies on the mechanisms involved in this feedback that integrate different biological levels with dynamictrio we will perform an indepth and multilevel analysis of the ecoevolutionary process by combining experimental evolution and theoretical modelling of a tritrophic system composed of plants arabidopsis thaliana herbivores tetranychus urticae and predators amblyseius swirskii first we will quantify the impact of ecosystem productivity and environmental stress on ecological dynamics aim 1 second we will address how the interplay between ecosystem stability and population dynamics determine trait and genomic evolution aim 2 third we will examine how the evolution of direct and indirect interactions affect species evolution and ecosystem resilience aim 3 finally using the huge body of experimental data produced we will examine how population dynamics system stability and interspecific interactions shape the genotype to phenotype to fitness map of each population this will allow us to incorporate the ecologyevolution feedback loop into fitness landscape models aim 4 by building on the combination of powerful empirical and theoretical approaches which i have been developing throughout my career dynamictrio provides an extensive multidisciplinary understanding of the mechanisms underlying ecoevolutionary dynamics the longterm goal of dynamictrio is the development of statistical and theoretical tools that properly integrate the different components of the ecoevolutionary loop and generate the muchneeded predictions on how a broad range of ecosystems persist in a fastchanging world
monolithically integrated reram and inchip cooling for emerging neuromorphic applications

heat generation and removal thereof is one of the main challenges for the realization of many future high performance electronics the heat wall is one of the biggest obstacles to processing large amount of data using the conventional computing architectures to address this formidable challenge smart architectural approaches that consider codesign of electronics and thermal management as well as emerging solutions beyond cmos are needed a resistive switching memory cell reram is a promising candidate for such a technology which offers performance improvements in digital circuits without a need for aggressive device scaling when combined with transistors ultimately the solution may come from monolithic integration of novel electronics and cooling within the same substrate inchip cooling has been recently demonstrated to be promising in gan power electronics on silicon however the multistep and complicated process flow adopted for fabricating the inchip heat sink in the stateoftheart could pose a big challenge for the wide adoption of this new scientifically and technologically interesting concept 3d laser lithography is a currently unrealized opportunity to fabricate inchip microchannels for cooling with substantially simplified fabrication and without a need for cleanroom facilities complex 3d structures can be fabricated by this method through a twostep process that includes femtosecond laser irradiation followed by wet chemical etchingin view of the above mentioned we target to develop memristive arrays integrated with lasermicromachined inchip cooling this offers an immediate and rapid path to overcome the thermal challenges facing todays computing architectures and is of relevance to other technologies that suffer from heating during operation we seek to exploit the highly efficient embedded cooling to pioneer agenda setting advances in addressing the wellknown thermal limitations of future logic and memory technologies
tracing virusspecific cd8 t cell clonotype zonation and function in humans

the current covid19 pandemic highlights the need to gain better understanding of precise mechanisms that enable immune control of viral infections although it is established that cd8 t cells are required to suppress viremia most view these cells simply as killer t cells based almost exclusively on studies of blood i recently discovered that efficient immune control of hiv is mediated primarily by nonkiller resident memory cd8 t cells whereas cd8 t cells with high killer instinct are mainly confined to the vasculature these observations force a reevaluation of how antiviral cd8 t cells are distributed anatomically and function in the tissue spaces where most viruses replicate using cuttingedge singlecell technologies on unique paired tissue samples from human organ donors my aim here is to challenge prevailing concepts in the field of adaptive immunology and reassess how and where cd8 t cells actually target viruses in the human body my group will first use singlecell barcoding techniques to establish a reference map of cd8 t cell clones specific for multiple viruses across tissue sites we will then dissect this information to determine whether distinct resident memory cd8 t cell clones andor subsets exhibit differential antiviral functions across tissue sites in parallel we will use more mechanistic approaches to define the epigenetic imprints and functional properties of antiviral cd8 t cells aiming to determine to what extent these features are shaped by subset fate anatomical location andor the nature of the expressed t cell receptor a specific emphasis throughout this project will be to translate the emerging knowledge to the field of covid19 aiming to understand how cd8 t cells control sarscov2 this ambitious but technically feasible project will establish a systematic foundation for future studies of antiviral t cells in humans and inform the development of more effective vaccine platforms to combat future viral threats
from light fueled selfoscillators to light communicating material networks

online aims to develop new concepts of communication between inanimate materialswhat is meant by communication in biological context communication refers to interactive behaviour of one organism affecting the current or future behaviour of another in the context of bioinspired materials online will develop lifelike material structures that communicate with each other via physical contact fluidic medium or optical beams these inanimate materials will be coupled to form networks that communicate autonomously through lighthow to make them the core concept behind the communicative materials is selfoscillatory selfsustained motions in lightresponsive liquid crystal elastomers lces selfoscillation is a responsive structure that can selfsustain its own mechanical motion in a constant energy field it captures the key concepts of living organisms ie functioning out of thermodynamic equilibrium and energy dissipation my goal is to scale down the selfoscillator concepts to the microscale and realize soft material robots that can communicatewhy is this important there exists an increasing need for artificial materials that can interact alike biological systems however all the dynamic features of stateoftheart responsive materials are based on internal material properties and making individual materials interact with each other is a huge challenge online proposes three new model systems for material communication i microscopic walker swarm in which the locomotion and patterns of interactions between individuals can be fully programmed ii cilia array that move cooperatively and selfregulate the fluidics at low reynolds numbers iii homeostasislike lightcommunicating coupled network that provides a full set of tunable parameters to mimic the complexity of biological oscillators
harmonization of advanced materials ecosystems serving strategic innovation markets to pave the way to a digital materials product passport

the overarching objective of digipass is to enhance the digital maturity of the european communities that develop materials and intermediate products the project will develop recommendations and clear routes toward digitalized circular business models the overarching key result of digipass is to create a sustainable platform which includes support for digital materials product passport and for collaborative innovationbydesign processes in a circular economy served by advanced materials a business model for operating such a platform completes the overarching objectivedigipass is harmonizing and synergizing collected materials data sources and digital infrastructures this will enable interoperability of data exchange and standardization of advanced materials knowledge representation at all maturity levels accelerating the design development and production of advanced safe and sustainable chemicals and materials as they are necessary for innovative products calls for a collaborative approach involving different stakeholders to support durability repair and overhaul reuse and recyclability of products digipass project impacts all materials development communities over the whole circular value chain
gn51

as one of the first in a series of projects foreseen under gn5fpa gn51 aims to provide faster more resilient and secure connectivity infrastructure and collaboration services to enable researchers and students access to applications that support evidencebased and effective collaboration across virtual research teams worldwide gn51 will continue the development of stateofthe art costeffective secure and resilient connectivity to provide unconstrained capacity ahead of demand in the backbone network and nren access in multiples of 100gbps delivering terabit connectivity where needed gn51 will prototype pilot and where appropriate procure new online abovethenet services and deliver pervasive innovative and distributed trust and identity infrastructure and services to achieve strategic positioning of ti services as a key enabler of research and education collaboration within europe trusted access to data sources and services and authentication and authorisation infrastructure services such as eidas will also be included the project will address horizon europes priorities in areas such as data security and access control innovation and dnsh and will expand nrens users beyond traditional scientific and research communities enabling networking and access to the common european data spaces gn51 will ensure access for researchers and students to the valued services required for open science it will disseminate learning and training and build community as well as align with eu policies and ongoing participation with standardisation bodies gn51 can offer its distinctive services due to its human network of professionals in a consortium with a deep understanding of evolving user requirements within this community knowledge and experience is shared between partners to constantly enhance the quality of the services offered making it an indispensable element of the era
betacell recovery to counter diabetes

globally 875m people with t1d rely only on insulin administration to manage the symptoms of their disease the treatment is complex since it requires injecting insulin 24 timesday and adhering to a restrictive lifestyle eg following a strict diet reducing patient qol even with insulin less than 20 of patients achieve their target glucose level which eventually leads to vascular complications eg stroke renal disease reducing life expectancy by 1015 years diogenx aims to withdraw insulin dependency and cure t1d by regenerating pancreatic betacell to allow autonomous insulin release in response to blood glucose levels increaseswe expect to outlicense our drug to a pharma company some of them have already manifested their interest and invested in the capital of diogenx this may materialize as soon as clinical proof of principle is demonstrated in humans which will be reached in 2026 with the proceeds from series a to be raised in 2023 which is 80 secured