Dragon09/odtu_chatbot huggingface dataset:
youthdecide 2040 visions of democracy with and for future generations

democracies in europe have demonstrated resilience and modernisation in the face of various social and technological challenges democracy in the age of the anthropocene will necessitate radical shifts in values power relations and modes of governance while also being built on the present in all its diversity paradox and insufficiency innovating to meet these challenges will require reimagining how people living in democracies become equipped and supported to cocreate resilient democratic futures in europe and beyond clear visions are needed to build strategies that allow for rethinking and redesigning spaces institutions instruments and ways to represent and include people in democratic governance youthdecide 2040 aims to support european union democracy to rise to these challenges through evidencebased historical and contemporary knowledge strategic foresight and robust deliberation specifically youthdecide 2040 has the main objective to cocreate with european youth and older generations political and institutional actors and organised civil society coherent pathways to desired futures of democracy in the european union in 2040 we translate our main objective into a series of research questions that need to be answered to support the work each question is connected to a key objective and corresponding work packages to support cocreation the questions and objectives presented below are in order of workflow not in order of importance all activities are planned to be inclusive and open processes transparently documented along the way to enable repetition and implementation beyond the life of the project the projects ambition is to reinvigorate democracy in and across europe with visions and pathways made with active and inclusive citizen participation for becoming more resilient to current and future challenges
modelling trajectories and mechanisms of childhood hip dysplasia

with 40 million patients in europe osteoarthritis oa is the most common chronic and disabling disease oa is incurable and symptomatic treatments have limited effect therefore prevention by identifying and targeting asymptomatic persons that develop a clear oa risk factor is sorely needed hip dysplasia is the strongest risk factor for hip oa hip dysplasia is a condition of mechanical instability of the hip caused by insufficient coverage of the femoral head ball by a shallow or obliquely oriented acetabulum socket this results in high cartilage stress and subsequent hip oa in europe we screen for developmental hip dysplasia in infants prevalence 2 enabling early treatment however we discovered that hip dysplasia can further develop during skeletal maturation and thus remains unrecognized in 1100 dutch 9yearold children we found a 6 and 26 prevalence of marked and mild hip dysplasia respectively hip dysplasia can be influenced until the stage where hip growth plates close at about age 13 i propose a novel research program hipstar where i will uniquely unravel the mechanisms behind late childhood hip dysplasia in order to pave the way for devising preventive measures that reduce the prevalence of adult hip dysplasia and thus hip oa in a birth cohort of 8000 children followed from foetal life until adulthood i will first uniquely built a 5d growth model on how hip shape develops over time from age 218 years i will gain novel knowledge regarding causal factors of dysplastic growth and whether there are various phenotypes that have different underlying mechanisms i also will study how and when dysplastic growth will already impact on the integrity of the young adult joint and discover very early signs of joint aberration leading to oa finally in a computational model i will test the influence of loading factors on dysplastic growth mechanistically and provide detailed information regarding the potential remedial options
adaptive microcombs for innovative connectivity in datacenter applications and optical clocks

the rampant growth of ict applications such as ai is moving an increasing amount of computing resources to datacentres datacentres are responsible for approximately three quarters of the internet protocol data in the world the continuous increase in data traffic and bandwidth demands are challenging the status quo of the datacentre interconnect architecture the outstanding challenge for the next decade is finding scalable and efficient solutions to enable the bandwidth density that will be neededcopackaged optics cpo is the enabling technology to drive this shift in the computational efficiency paradigm and the market in silicon photonics with largest forecasted cagr in 20222026 with potential multibillion dollar revenues beyond 2030 cpo is based on decreasing the distance of powerhungry electrical interfaces by cointegrating optoelectronic modules on the same interposersin order to drive the scaling in optical edge bandwidth density multiwavelength laser sources for densed wavelength division multiplexing will be needed but state of the art commercial solutions face fundamental scaling issuesamica builds upon a breakthrough waferscalable superefficient microcomb technology to realize critical demonstrators in wdm cpo aiming at petabitpersecond aggregate speeds in a massmanufacturable platform with unprecedented combination of channel count efficiency line spacing and power per line the consortium brings a synergetic effort among an industrial leader in datacentre interconnects and highperformance computing academic partners with complementary expertise in integrated photonics and an emerging startup that owns the intellectual property rights for commercialization the team is complemented with an innovation office to lead the tech to market transition and two associated partners who will help testing the technology for emerging markets beyond telecom
cure for miniature brittle bones treatment of osteogenesis imperfecta patientderived bone organoids with innovative aavmediated ultimate geneediting system

osteogenesis imperfecta oi also known as brittle bone disease is a prevalent rare skeletal condition with limited treatment options available and no known cure individuals with oi endure numerous bone fractures throughout their lives to address the urgent need for an oi cure morbius aims to create a gene therapy employ a cuttingedge aavmediated gene editing to curatively repair the genetic defect in a model of patient bone tissue mini brittle bone within morbius i will 1 construct mini brittle bones an oi patientderived induced stem cellbased bone organoid system and 2 repair the genetic defect in the mini brittle bones with the aavbased crisprcas and generide strategy to this end with access to one of the largest oi cell line biobanks in the world i will combine highly innovative induced stem cell development techniques with the existing expertise in fabrication of bone organoids of the hosting team and genome modification competence of secondment hostspecifically i will optimize a method of oi patientderived induced mesenchymal stem cells embedding in a decellularized extracellular matrix to promote their natural differentiation and formation of mini brittle bones crafted mini brittle bones will be transduced with bonedirected aav vector carrying crisprcas and generide systems to correct patients genetic defect by targeted insertion of a donor sequencein synergy with gene therapy research during a nonacademic placement with an oi patient organization an interactive multilingual educational webapp on oi gene therapy and genetics will be developed this will ensure early knowledge sharing awareness building of trust and encouragement of oi individuals to actively engage in gene therapy advancements morbius outcomes will enhance the quality of life for individuals with oi and other rare bone disorders but introduction of effective gene editing bone organoid modeling and knowledge sharing methods
zof zona franca ideas of territory in the carolingian empire

the project zof zona franca ideas of territory in the carolingian empire will investigate and visualise early medieval ideas of territory specifically in the southeastern regions of the realmzof will use a new and unique twopart approach firstly investigating early medieval source texts using theories of critical and discourse theories as well as cultural geography and secondly applying techniques and methods from digital humanities critical geography and gis to analyse the sources and visualise the research findings this will permit a fresh view on early medieval territories and territoriality as represented in the written sources one important step towards this is the inclusion of spatial narratives and terms that hitherto were cast aside as not plausible all early medieval discourses on territory in the broadest sense will be included in zof the resulting data will be stored in an openaccess database and visualised in an interactive map application zofmap this application will use new and more accurate methods of visualising medieval territories than traditional historical maps or gis zof will be using methods of critical cartography mental mapping and deep mappingas an open access online application zofmap will reach a wider public and thus give a broader audience access to cutting edge historical research
longrun inequalities in health and survival between families and across generations

worldwide life expectancy has increased strongly over the past decades but social inequalities in health and mortality are large and increasing in contrast to trends in socioeconomic inequality and social mobility longterm developments in inequality in health and mortality have been poorly documented relative health aims to quantify the level of inequality in health and mortality from a family perspective 1800today characteristics that affect health and mortality accumulate in families and thus the level of inequality in health and mortality can be quantified by addressing similarities within families in health and mortality samegeneration relatives and intergenerational persistence of health and survival ancestors and descendants the project has four main objectives1develop new ways to measure inequality in health and mortality using a revolutionary new perspective inequality between families and intergenerational persistence 2using these describe for the first time longterm trends in health and mortality inequality 3identify mechanisms that shape these inequalities between families and across generations4identify the role of contextual characteristics in shaping inequalities between families including the level of social mobility and social inequality stateoftheart population reconstructions cover up to 9 generations of relatives grandparents parents children in sweden netherlands and us 1800today and contain lifespan and health information the project lays the groundwork to generalize these estimates of family health inequality to many contexts with less abundant data sources using survey data these contain indicators of health and mortality for focal individuals their siblings and children for a range of low and middleincome countries covering 4 decades dhs 19842018 overall the project seeks to transform our understanding of social inequality in health and mortality across time and space
restoring a normal life and dignity for women and men suffering from severe stress urinary incontinence

severe stress urinary incontinence affects hundreds of millions of women and men in the world it is an ignored public health problem as it is often hidden for those who suffer from it it turns their lives into a living hell existing solutions are unsatisfactory for men manual artificial urinary sphincters aus require the scrotum to be manipulated for each voiding sometimes with the help of a relative for dependent people its humiliating these devices are associated with a significant rate of revision and explantation notably because of manually manipulated implantable components and the constant pressure exerted on the urethra often leading to erosion and atrophy the patient is plunged back into the hell of incontinence for good for women the most commonly used solution is mesh sling initially developed for cases of prolapse this solution leaves 15 of women incontinent with a further 5 suffering serious irreversible damage to such an extent that they are the subject of over 100000 lawsuits in the usa women are left without a safe convenient and effective solutionsevere incontinent people urgently need a safe and decent solution we are developing the first smart artificial urinary sphincter designed to solve all the drawbacks of current devices uroactive is connected voiding is done by remote control or by gently tapping on the abdomen no more genitals manipulation selfadjusting the occlusive pressure is automatically adjusted depending on patients position and activity personalized the surgeon can wirelessly adjust device parameters after implantation secure if the patient cannot control the device or loses consciousness the device automatically opens to prevent overpressure in the bladder and kidney injury uroactive will provide an efficient reliable easy to use and safe solution to minimise the risk of side effects and gives their lives and dignity back to patients
developing crispr activationcrispr interference toolset for finetuning production of metabolites in plants

plants produce a great variety of specialised metabolites in plants they are often involved in interactions with their environment but many of them have applications in pharmaceutical cosmetic and food industries making them targets for metabolic engineering efforts aiming to increase their production plant metabolic engineering is usually based on metabolic pathway reconstitution in microbes but recently direct activation of biosynthetic genes has been done in plants using crispr tools metabotune aims to develop a crispr toolset for simultaneous activation and inactivation of metabolic genes to finetune biosynthesis and maximise yields of specialised metabolites first i will develop a crispr interference crispri tool for inactivating genes that channel metabolites into undesired metabolic pathways second i will identify genes involved in the biosynthesis of a coumarin metabolite with medicinal properties esculetin finally crispri will be applied together with the already available crispr activation crispra tool in development of plant cell cultures specifically producing esculetin and the minimal amount of other coumarins to achieve these objectives i will combine my expertise in molecular biology genetics specialised metabolites and biochemistry with the expertise in metabolic engineering and coumarins available at the host institute allowing precise channelling of metabolites into pathways of interest as proposed here will open new venues for highly specific plant metabolic engineering efforts and allow a shift from production in microbes to increasing production in plant species that already have genes required for biosynthesis of highvalue specialised metabolites
urban cocreative sustainable and inclusive ecosystem for the recycling of reinforced polymers onthetruck

yourban cocreates an active urban ecosystem for the recycling and upcycling of objects and materials in relation to reinforced polymers coming from local environment the project activates an urban setting of citizens artists designers architects smallscale producers artisans and urban factories yourban is engaged in the new european bauhaus and the green deal principles of aesthetic and environmental balance alongside sustainability and inclusion parameters through regenerative design and manufacturing encouraging dialogue across cultures disciplines professions genders and ages a local and flexible decentralized production system is generated in two european cities both linked to the climateneutral and smart cities eu mission milan and barcelona two complementary pilots will cocreate new objects through a neighbourhood participatory approach supported by collaborative digital tools the material recycling and reprocessing experiences will go through a 10day event around a mobile plant on board of a truck that will be placed in the city and open to all actors experts will be available to provide knowledge and training citizens will be involved to provide needs and expectations artists will be engaged through artistic residences to provide solutions inspired by art and culture beyond functionality urban factories will participate thanks to a cascade funding mechanism yourban performs social sustainability inclusion worklife balance humancentered innovation involvement of marginalized groups knowledge sharing job skills generation employment opportunities environmental sustainability waste and transportation impact reduction benefits in terms of co2 emissions no dependency on critical raw materials economical sustainability relevant market opportunities and related economic returns to european manufacturing companies which will enable the sustainability of the initiatives in the city even after the end of the project
laserpatterned hierarchical porous electrodes for the foreseen iontronics technology

laserions main objective is to develop robust and efficient hierarchical porous laserpatterned film lpf carbonized electrodes ce for unprecedented ion sensing by electrochemistry laserions ambition aligned with the eu green deal 2050 carbon neutrality roadmap and united nations goal 9 is to contribute simultaneously to climate neutrality while proposing a new technological path to reinvent the modern electronical industry for that purpose the research fellow rf will conjointly with the host scientist prepare sustainable electrodes through valorization of biobased polymers via three material engineered strategies centered at the co2laser carbonization namely porogen agents before wp1a controlled atmosphere during wp1b and conductive polymers after wp1c the resulted carbonized based electrodes using lignosulfonates as the carbon source will be characterized with an extended portfolio of routine wp3a and advanced wp3b techniques listed in section 31 the same lpfce will be tested via electrochemistry in a newly engineered designed cell wp2 such electrochemical tests are divided in two configurations standard wp4a threeelectrodes cell working counter and reference and a more sophisticated cell wp4b with an additional potentiostat to provoke an electromagnetic stimulus combinedly wp5 deals with training communication dissemination and strategic network building finally wp6 is dedicated to project management specifically in the technical administrative financial and ipr aspects by accomplishing these ambitious work packages tasks and objectives towards unprecedented lpfce evaluating their ion sensitivity capacity in liquid using a new custom bipotentiostat electrocell laserion attempts to provide a qualified training to the rf while delivering a potential technological readiness level 3 with an untapped modern co2laser pyrolysis conversion of ligninbased pulping residues for a needed circular economy
legitimate crisis management and multilevel governance

legitimult assesses the impact of the measures taken by various international national and subnational governments on multilevel institutions and intergovernmental relations in the wake of the covid19 pandemic the project analyzes the effect of these measures on democratic governance highlighting to what extent multilevel governance influences their impact on democracy favoring a model of legitimate crisis management it assesses all measures taken by 31 european countries in relation to their impact on multilevel governance through the creation of a new dataset highlighting how these procedures link to multiple orders of governance who and eu above the states and regional and local governments below the national level the impact of these measures is analyzed through the lens of a variety of dimensions that characterize functional democratic governance rule of law and democratic participation human and minority rights trust economic sustainability legitimult qualifies the different tradeoffs required within and across these dimensions in order to effectively and quickly deal with a crisis such as covid19 while at the same time maintaining a level of democratic governance and ensuring that any limitations to democratic standards are limited these final tradeoffs within and between the different dimensions of democratic governance in crisis management are gathered in a set of policy recommendations tailored to different recipients and developed through extensive consultation with stakeholder groups throughout the project citizens policy makers and practitioners are involved in the experimental phase of the project where interactive learning and practical tools are tested but also codesigned and corefined with relevant stakeholders in a participatory way policy recommendations and practical tools merge into a toolkit for legitimate crisis management ready for use in possible future crises
neffa new fashion factory is increasing business opportunity 4 scaling

neffa is the first sustainable automated manufacturing method to create customfit textile products from biomaterials starting with mycotex first we grow mycelium the root structure of mushrooms we use liquid fermentation and only work with food grade ingredients then the mycelium is filtered mixed with ingredients and pigments and robotically applied around affordable recyclable moulds after drying and finishing the product is ready to be worn we can grow and make the product from scratch within only 7 days this patented process gives you unprecedented design freedom to create silhouettes and textures that were never possible before with traditional manufacturing processes all while guaranteeing a perfect fit we offer a supply chain based on automation and make local and ondemand production possible and it is circular as our method is based on natural materials and the elimination of waste with this project neffa is looking to increase their business opportunity in order to become the next manufacturing method next to cutting sewing it is based on 3 parts the first part is focusing on reaching fast fashion pricing the second part on creating larger products and the third part is on business development and training when approaching male dominant companies and investors