Dragon09/odtu_chatbot huggingface dataset:
catalytic htl coupled to microwave pretreatment for low nitrogen microalgal biocrude

the transport industry is going through a revolutionary moment in its quest to reduce its carbon footprint with biofuels being one of the viable options high productivity lipid content and its ability to capture co2 make microalgae a competitive biomass new technologies such as hydrothermal liquefaction htl has recently attracted the attention in research as it avoids the energycostly drying step and produces biooil at mild temperatures nonetheless conventional htl process suffers from biocrudes high nitrogen content mainly caused by protein content furthermore the biocrudes high oxygen content reduces its calorific value making biocrude unattractive in addition to its high nox emissions during combustion since nitrogen and oxygen in biocrude respond differently to processing temperature an approach that would favor simultaneous reduction of both would be revolutionarythe nitrogen removal before the main htl process could be the solution in this perspective the combination of microwave pretreatment and htl process can be promising however this nonselective method may compromise biooil yield in microwcathydron we investigate nitrogenselective catalysts to specifically target nitrogen compounds and maintain the tradeoff between desired biooil yield and properties the catalytic activity of nickel can promote hydroisomerization and deoxygenation reactions thereby improving biooils cold flow properties and heating value overall this green chemistrycompatible route is economically and technically feasibleindustrial scaleup of algae conversion requires a complete characterization of its complex degradation mechanisms and phenomena occurring during the process in order to understand how nitrogen compounds are formed and consumed in this sense microwcathydron aims to develop a new chemical kinetic model for parachlorella kessleri liquefaction in conclusion research is expected to increase the production of highquality biooil
systematic and orchestrated deployment of safety solutions in complex urban environments for ageing and vulnerable societies

the emergence of complex urban mobility environments where unknown interactions between different types of vulnerable road users vrus and between vrus and motorised vehicles poses the need for a clear understanding of user behaviours fair and optimised use of public spaces as well as age friendly urban safety action plans and assessments capitalising on the benefits that technological innovations and the plethora of available data can offer in advanced accident analysis towards achieving eus vision zero for zero fatalities in road transport by 2050 soteria aims to accelerate the attainment of this vision for vrus through a holistic framework of innovative models tools and services that enable data driven urban safety intelligence facilitate safe travelling of vrus and foster the safe integration of micromobility services in complex environments at the operational level soteria uncovers unexplored behavioural characteristics of vrus and engages living lab communities in social innovation activities for the cocreation of urban safety solutions and infrastructure designs simulation models and explainable ai driven analytics are developed for supporting policy decisions and informing interconnected services that support vrus in safe and clean travelling onvehicle sensors and connectivity are fostered enabling minimisation of risky situations and behaviours the approach is validated in four thematic demonstrations and through the soteria network of eight cities addressing different types of vrus
remote controlling biological systems by sonopharmacology and sonogenetics

to date light has been employed as a widespread trigger to achieve control over the activity of drugs and protein function establishing the fields of photopharmacology and optogenetics respectively both techniques led to promising new therapies the elucidation of brain function or understanding of neural disorders however serious limitations resulting from the low penetration depth of light into tissues are severely hampering progress in these fields in contrast to photons ultrasound deeply penetrates tissue and can be applied with submillimeter resolution and consequently has been widely established in the clinic over many decades for therapy and diagnosticsin this erc advanced grant i will develop a radically new approach to control the activity of drugs proteins and genes by biocompatible ultrasound polynucleic acid carriers which can bind a wide variety of bioactive payloads will be designed to be sensitive to different ultrasound sources which can be applied in clinical settings and do not harm cells or tissues upon ultrasound irradiation these carriers liberate their bioactive payloads by mechanochemical principles to switch on drugs and control cellular functions to achieve this aim i will investigate the effect of ultrasound us on nucleic acid architectures study the loading of polynucleic acids with different payloads and their release by us develop a technology platform to activate small molecule drugs proteins and oligonucleotides and showcase the huge potential of these technologies for cancer immunotherapy diabetes research and tissue engineeringthis project will boost sonopharmacology and sonogenetics its outcomes will enable spatiotemporal control of drug action to minimize side effects in pharmacotherapy like cancer the remote controlled orchestration of protein and gene function by us will strongly advance medicine and the life sciences by answering fundamental questions in these fields
solving the bz problem in heliospheric weather forecasting

a major unsolved problem in space weather involves predicting the solar wind at the sunearth l1 point specifically its speed and the northsouth bz magnetic field component knowledge of the future solar wind time evolution would allow us to drive any models for magnetospheric processes such as the aurora the radiation belts the ionosphere or the currents induced in power lines with much higher reliability and forecast lead time than currently possible our modern society increasingly depends on space borne technology and predicting extreme space weather conditions at earth is therefore of pivotal importance our hypothesis is that we can predict the strongest bz fields in magnetic flux ropes in solar coronal mass ejection cmes with a novel combination of hyperfast semiempirical models in our new helio4cast simulation capable of running millions of ensemble members within minutes due to the coherence of flux ropes it will be possible to forecast geomagnetic storms with lead times of 12 hours or more additionally for clarifying unsolved problems on the cme global shape and magnetic structure a window of opportunity has opened at the start of solar cycle 25 with the successful launches and operations of solar orbiter parker solar probe and bepicolombo forming an unprecedented fleet of spacecraft to study cmes groundbreaking numbers of multipoint lineup events solar orbiter imaging for the first time from higher latitudes and novel in situ data from parker solar probe close to the sun will lead to new discoveries these unique observations in the solar wind will also deepen our knowledge of stellar cmes the team is lead by an accomplished pi with the necessary broad scientific expertise this erc project provides an unconventional direct feedback loop between answering open scientific questions and the application of forecasts in real time that will bring decisive progress in making a reliable space weather prediction part of our daily lives
thz industrial mesh networks in smart sensing and propagation environments

future wireless networks are envisioned to support novel applications that require similar performance as wired networks in terms of data rate tbps ultralowlatency well below 1 ms sensing eg mmlevel localization accuracy and reliability eg 1 in a billion transmission error the current 5g approaches have a hard time keeping up with such envisioned applications times addresses this problem by combining novel radio channel propagation measurements and modeling approaches spectrally efficient and reliable communications at terahertz thz spectrum bands with intelligent mesh networking protocols and smart sensing and shaping of the propagation environment through reconfigurable metasurfaces while the fundamental technologies developed will be applicable to different beyond5g scenarios times will focus on an industrial setting since many of the envisioned applications in this complex scenario eg cooperative robots predictive maintenance realtime closedloop control require concurrent high performance reliability and sensing capabilities to tackle the challenge times extends the stateoftheart on three fronts 1 propagation channel measurements and characterization in thz bands including measurement and modeling of metasurfaces and electromagnetic leakage in complex scenarios 2 developing technological enablers for reliable thz communications eg smart beam management ultramassive mimo thztailored phy and mac design metasurfaces and new meshbased architecture and 3 implementation of a thz mesh network prototype including design and fabrication of both active transceivers and passive metasurface nodes to validate selected technological enablers developed in times
epigenetic memory by communication across chromosome scales

the ability of cells to specialize and maintain their identity through multiple cell divisions is critical for development tissue renewal and diseases avoidance a key frontier is therefore to understand how genome organization and function is inherited to daughter cells epichs targets a new paradigm for how epigenetic information is propagated in which communication between the 2d epigenome and 3d genome organization maintains cellular identity inheritance of epigenetic states involves the copying of modifications on dna and histones in cis on replicated dna however this model lacks a spatial dimension integrating that similar chromatin types separate spatially in the nucleus and replicates in a coordinated fashion dna replication severely disrupts the 2d epigenome but it is unknown how replication locally impact on 3d organization and how spatial context shapes replication of the epigenome epichs will interrogate chromosome replication across scales we will develop new technology to address the interplay between 2d and 3d epigenome in epigenetic inheritance across replication we will combine these technologies with machine learning proteomics and fastacting degrons to manipulate chromatin replication functionally we will explore replicationinduced 2d3d dynamics and inheritance mechanisms in regulation of transcription and stem cell plasticity together this will 1 provide the first knowledge of interdependencies and directionality in propagation of 2d and 3d organization 2 reveal functions of dna replicationinduced plasticity in cell fate transitions and 3 unveil spatiotemporal epigenetic mechanisms and their synergy with cisbased memory in maintaining cell identity
gn52

under gn5fpa gn52 continues delivering expanded cost effective secure and resilient connectivity for unconstrained capacity ahead of demand in the backbone network and nren access in multiples of 100gbps targeting terabits connectivity where needed gn52 will scale its digital service portfolio to changing environments by prototyping piloting and where appropriate procuring new online abovethenet services to enable researchers and students access to applications that support multidomain datadriven evidencebased and effective collaboration across virtual research teams worldwide it will deliver pervasive innovative and distributed trust and identity infrastructure and services taking into account open science and eidas to achieve strategic positioning of ti as a key enabler of research and education collaboration within europe gn52 will reinforce the network security and its operation in a federated approach and foster collaborations to innovate and strengthen europes sustainable connectivity with other world regionsgn52 will address horizon europes priorities in areas such as data security and access control innovation inclusion and dnsh and will expand nrens users beyond traditional scientific and research communities enabling networking and access to the common european data spaces and preparing nontraditional use of fiber sensing technologies quantum timefrequency distribution gn52 will ensure access to the valued services required for open science disseminate learning and training and build community as well as align with eu policies and ongoing participation with standardisation bodies gn52 can offer its distinctive services due to its human network of professionals in a consortium with a deep understanding of evolving user requirements knowledge and experience are shared within this community to constantly enhance quality and security of services indispensable to the era instrumental to eu strategic autonomy
living therapeutic and regenerative materials with specialised advanced layers

skin is a living interface with layers of specialised functions sensing regeneration protection the level of complexity in skins is currently unreached in engineered living materials elms here we will create skininspired elms with layers with living cells specialised properties and functions our living skins are based on a grown matrix hosting engineered multicellular consortia that build and functionalise different layers spatiotemporal patterning is realised by genetic control and the physicochemical properties of cells and biomolecules our aim is to generate platform technologies to advance biological elms and make two proofofconcept engineered living skins with different applicationswe will fabricate a selfencapsulated living therapeutic skin lts made of a bacterial cellulose hydrogel matrix with senseandrespond cells lts will have an interactive layer with sensing functions a core layer for responsive living cells and a barrier layer for biocontainment and hydration an example lts will be designed to sense pathogenic skin bacteria in eczema and release biosynthesised therapeutic moleculesa dry and tough living regenerative skin lrs consisting of biomineralized biopolymers hosting bacterial spores will be fabricated as an alternative to traditional inert materials ceramics plastics in protective garments the lrs biomineralized core will arrange in microscale layers like tough biominerals in nature nacre bone dentin lrs will be encapsulated in an activator shell engineered to prevent water penetration and to memorize local mechanical experience giving local selfreinforcement of mechanically stressed regions a unique property compared to current materials and other elmsas a powerful strategy to accelerate the adoption of our living materials in society we will systematically involve the potential endusers and designers in our research for the materials and product development to happen in synergy
learning the dynamic statistical folding of bacterial chromosomes

the physical organization of bacterial chromosomes is inherently variable with large conformational fluctuations both from cell to cell and over time yet chromosomes must also be structured to facilitate processes such as transcription replication and segregation a physical description of this dynamic statistical folding of bacterial chromosomes remains largely elusive hic experiments probe chromosome organization by measuring average contact frequencies of chromosomal loci pairs despite the rapidly expanding database of highresolution hic data for many bacterial species and conditions these data are still mainly interpreted on a casebycase basis and with qualitative or heuristic methods my goal is to develop a principled unifying approach to infer and analyze the dynamic organization of chromosomes from bacterial hic data this datadriven approach aims to unravel the dynamic statistical folding of chromosomes and its impact on functional processes in growing and replicating bacteria we will infer a bacterial chromosome model from stateoftheart data using learning methods at the intersection of information theory and statistical mechanics by combining datadriven with mechanistic modelling approaches we aim todecode information contained in hic data by learning both 3d steadystate and 4d dynamic models for the statistical organization of chromosomes provide a unifying statistical mechanics analysis of the dynamic statistical folding of chromosomes across bacterial species under both steadystate and replicating conditions develop theoretical methods using pairwise and multicontact statistics to study the topology of statistical chromosome folding my research will advance the field by providing a conceptual understanding of the physical and mechanistic principles that underlie chromosome organization in developing bacteria this work could shed new light on vital functional processes such as chromosome segregation
supporting policy regulations and interventions to negate aggravated global diarrheal disease due to future climate shocks

background global warming and climate extremes such as heavy precipitation flooding and drought are increasing risks for waterborne diarrheal disease while these effects already burden low and middleincome countries where diarrheal diseases are the second leading cause of childhood deaths europe has shared and underappreciated vulnerabilities there is an urgent need to prepare and protect our water and communities from these threatsaim to inform key climate environmental and health adaptation policies in order to support and prepare citizens communities and governments by better measuring the impact of future climate shocks on the burden of waterborne diarrheal diseasesapproach we bring together scientists from climate environment health and social sciences to collaborate with communities industry public authorities and policy makers across socioeconomic settings we will model the future impact of global climate change on local water quality and quantity and diarrheal disease outcomes in case studies in ghana tanzania italy and romania we will measure current interactions of climate behaviour and water quality on pathogenspecific diarrheal disease risks and the safety of water supply systems we will engage individuals and communities to understand situated understandings and practices to improve risk communication and ownership with policy makers we will design appraisal structures to assess the economic impact and value of planetary health interventions to prevent climaterelated diarrheal diseaseimpact springs will improve integrated climate and health surveillance create climateresilient water supply systems engage citizens and stakeholders and use evidencebased value assessments to prioritise interventions to prevent climateinduced diarrheal disease long term adaptive capacity and climateresilience will increase in europe and beyond preventing unnecessary illness and deaths from waterborne diarrheal disease
if you are not healthy you are out how honey bees develop resilience towards invasive species events with an immune system at the colony level

honey bees apis mellifera have experienced the full impacts of globalization including the recent invasion by the parasite varroa destructor this deadly mite has rapidly become one of the main causes of colony losses worldwide with a huge economic impact on beekeeping despite the lethal effects of varroa some colonies survive infestation in such colonies honey bees are able to work together to selectively remove highly parasitized brood thereby limiting mite spread defensive hygiene plays a role at society level that parallels that of an immune system and the social immunity it confers provides the basis for colony resistance to varroa and other brood diseases how compromised individuals are accurately diagnosed and how the collective actions of hygienic bees are regulated at colony level pose central but yet unsolved challengesthe bee healthy project aims to decipher the mechanisms that underpin collective behavioural defences against unhealthy brood in honey bee colonies four key breakthroughs support my highrisk highgain and widescoped approach 1 a new conceptual framework postulating that bees maintain the integrity of the colony by constantly assessing the wellness of conspecifics 2 a new hypothesis that considers distinct hygienic behaviours as components of a single suite of defences that must be considered together 3 a cuttingedge experimental strategy that tightly associates studies at the individual bee and superorganism colony level 4 an integrative biology approach that combines chemical ecology and neurophysiology this ambitious project promises an unprecedented journey in the understanding of social immunity in the face of increasing threats from invasive species events revealing how hosts adapt to detrimental foes has never been more pressing this research also opens avenues to deliver tools for a more sustainable beekeeping and agriculture through preserved pollination ecosystem services
eatrisconnect

since the establishment of eatris as an eric in 2014 the infrastructure has developed a growing portfolio of services and collaborative projects serving several user groups including industry large pharma and sme academia research funders and patients eatris has progressed from proposing a strong proof of concept service portfolio to building and delivering innovative tools for translational research and is now advancing its strategy to further exploit these tools for the extended research and innovation communityeatrisconnect will accelerate this strategy by focusing specifically on advancing the digital readiness of eatris to support biomedical challenges in europe and provide translational solutions for the benefit of personalised medicine through curated access to novel digital tools and services as well as node strengthening eatrisconnect will equip eatris across the entire distributed research infrastructure to address bottlenecks and challenges for the application of digital solutions in the context of use moreover the project will ensure this digital transformation is environmentally sound by improving energy resource and material efficiency supporting the environmental goals of the european green deal the project will promote the crossborder alignment in the adoption and application of digital tools and help consolidate the european ri landscape by fostering interdisciplinary collaborations between crosssector ri and exploring how ri can together unlock innovation in the digital domain eatrisconnect will provide the pathway for the evolution of eatris all 14 national eatris nodes form the central pillar of eatrisconnect facilitating the alignment of strategic national priorities across the infrastructure and empowering eatris widening nodes to strengthen their digital competencies ultimately ensuring the longterm sustainability of eatris