Dragon09/odtu_chatbot huggingface dataset:
activating learning paths holistic artsbased education and training for inclusion and cultural awareness

alphabetica aims to provide effective solutions that allow children and young people at risk of poverty or social exclusion to access arts and artsbased education through cocreative participatory research actions for some young people access to art is limited often understood as a luxury or a leisure activity that may feel inaccessible or irrelevant for others their creative endeavours might not be recognised from their own perspective as being art alphabetica will carry out 12 pilot actions across 8 european countries aimed at enhancing the transformative effect of active participation in communitydriven artistic cocreation activities collectively the research pilot actions cover a range of school settings and outofschool community settings with children from 3 to 18 as well as young people and adults of various ages the project is informed by a synthesis of theories of youth participatory action research theory of change pedagogies of care love and enchantment pedagogies of past present and the imagined future and the morethanhuman approach this conceptual framework invites a reflexive and indepth exploration of children and young peoples complex everyday realities while offering opportunities for creative selfexpression and meaningmaking participation skillsdevelopment and relationshipbuilding alphabetica will take a transformative approach by providing qualitative and quantitative data on attitudes towards and perceptions of arts by children families educators and policymakersusing participatory and caring approaches and pedagogies to provide an evidencebased assessment of the instrumental outcomes of artsbased education their transformative impact and their transferability to children and young peoples other life domainstaking and teaching a caring approach that through artsbased education will sustain a commitment to lifelong learningproviding evidencebased recommendations for policy action
smooth muscle cell modulation by the mar1lgr6 duo novel role in the resolution of human cardiovascular inflammation

atherosclerotic cardiovascular disease ascvd is a progressive disease characterized by aberrant immune activation and chronic vascular inflammation as a result from a failure in the resolution phase however the mechanisms responsible for this dysregulation are not well understood little is known about the role of smooth muscle cells smcs in regulating resolution of inflammation an active process orchestrated by endogenous specialized proresolving lipid mediators spms these include the maresin family and in particular maresin 1 mar1 which was recently shown to be a specific activator of lgr6 despite the potent antiinflammatory and proresolving actions of mar1 in murine models and human cells its role in ascvd remains uncovered hence this proposal aims to elucidate the role of smcderived resolution of inflammation in ascvd and the impact of mar1lgr6 in stimulating resolution specifically i will focus on the molecular mechanisms of mar1lgr6 signaling mainly on the phagocytic capacity of smcs i will employ mechanistic and functional assays in human smcs as a proxy for its potential in plaque clearing and plaque stabilization i will characterize the expression of lgr6 by mass spectrometry imaging and the biosynthesis of mar1 in human atherosclerotic tissue local and identify indicators in blood samples systemic by lcmsmsderived lipidomic profiling of human samples in to obtain a profile of systemic lipid biomarkers that reflects the local abundance of spms or their receptors this could be used to design personalized proresolving prevention in pronetocvd individuals lastly i will investigate the smc phenotypic modulation by mar1lgr6 in a lgr6specific smcdeletion ascvd mouse model deciphering the smcmediated resolution programs in inflammation a novel concept in ascvd and the involvement of mar1lgr6 in this process will be a major advance in understanding chronic cardiovascular inflammation and its mechanisms
highenergy microsupercapacitors based on lowcost materials

miniaturized energy storage solutions are key to powering the modern era of connected devices which is at the heart of internet of things iot concept microsupercapacitor electrodes with 3d architectures have drawn increasing interest in recent years due to their better energetic performances while maintaining a reduced footprint occupancy thin films of pseudocapacitive ruo2 active materials deposited onto highly porous pt current collectors sculptured via the hydrogen bubble templated electrodeposition have led to energy storage microdevices with extremely high power long lifetime and with energy densities competing with that of microbatteries these microsupercapacitor electrodes stand miles ahead from previously reported studies both in terms of their surface area and surface capacitance making them suitable for embedded electronics demanding high energyhigh power density per footprint areahowever the cost of ru and pt considerably limits their commercial applications on a large scale relegating rubased microsupercapacitors to niche applications the substitution of ruthenium with alternative transition metal electrodes characterized by lower cost and higher abundance is therefore a requirement to reduce the price of electrochemical microstorage systems and enable longterm sustainability for a wide range of applications in everyday lifethe eufunded 3dapp project will address this challenge in producing mno2 deposited on porous ni using simple and scalable processes that result highenergy electrodes that are economically feasible these electrodes will be combined with innovative ionic liquidbased electrolytes in solid form to achieve collective and scalable fabrication of lowcost prototypes onto silicon wafers or flexible polymer substrates
enhancing synchrony in autism introducing the mirrorpodsintervention platform

autism a neurodevelopmental disorder affecting millions globally severely impacts the quality of life of individuals diagnosed with this lifelong condition and that of their families it imposes an immense financial burden on health and educational systems projected to grow alongside increasing diagnosis and prevalence rates the magnitude of this crisis calls for more effective therapies that incorporate a nuanced contemporary understanding of autism recent research and therapies point to a core deficit of autism that has by and large been overlooked in existing clinical protocols and assistive technologies at temporal synchrony temporal synchrony refers to the harmonious alignment of actions behaviors or language over time autismsync introduces a pioneering intervention platform the mirrorpods that targets temporal synchrony the mirrorpods combine sophisticated technology with reallife human interaction and are tailored for autistic childparent dyads the dyad on opposite sides of a transparent touch sensor produce synthesized sound through hand movements using closedloop sensory feedback the sounds become more rewarding as the users movements become more coordinated the reward scheme is optimized to each users difficulty level to best promote improvement autismsync aims to explore the innovation potential through extensive user engagement and development the management plan includes establishing a private healthtech startup with long term plans for future commercialization this multidisciplinary venture aims to deliver a costeffective scientifically supported product poised to transform the landscape of behavioral interventions and at for autism under the management of a leadership team renowned for their expertise and dedication the mirrorpods which blend interactive technology personalization and direct human interaction pave the way for setting a new standard for care and support within the autism community
integrated assessment models with circular economy and material balance

for most of history economic growth has gone hand in hand with increased material use for a sustainable future we need to break this relationship we can reduce the material impact of the economy through less intensive use of materials longer use of materials over time and develop a circular economy where material loops to reduce losses the circular economy implements a more sustainable economic paradigm as opposed to the current linear economic model which is based on the extractconsumediscard tryptic the european union eu and member states also promote the circular economy as a political and economic target to inform policy makers on how to address sustainability issues researchers develop models such as integrated assessment models considering longterm growth and linking economic variables to biophysical features such as climate change however these models rarely include full material consistency and thus have limited say for circular economy innovations the objective of this project is to bridge the existing scientific gap between economic modelling and material flows to this end iamcirc will develop an integrated assessment model that combines macroeconomic characteristics with growth and circular economy features through material use constraints building economic theory and running calibrated scenarios with the model will allow to contribute to scientific research on circular economy and identify policy measures that combine socioeconomic objectives circularity and environmental strategies to be implemented at national and eu levels
democratizing cryogenic measurements for the quantum ecosystem

in the rapidly evolving landscape of quantum technology europe faces a critical gap in access to professional testing characterization services with a growing number of players entering the quantum ecosystem the need for a centralized advanced accessible facility to perform cryogenic measurements on sensitive devices is more pronounced than ever kiutra has a breakthrough solution to this challenge a stateoftheart lowtemperature characterization service leveraging our cuttingedge cryostat hardware this places us in pole position to offer rapid precise testing for an affordable fee cryogenicsasaservice reducing test result times from weeksmonths to days and lowering the bar to startups smes researchers without capitalexpertise to acquiremanage specialized lowtemperature hardware with our solution poised to transform markets kiutra presents a timely opportunity for eic support propelling our innovative european company to global quantum industry leadership
engineering cart cells to overcome glycosylationdriven tumour resistance

t cells engineered to express tumourspecific chimeric antigen receptors car proved effective against bcell tumours however as the technology moves to solid cancers clinical responses have not been as robust in this setting several barriers need to be overcome including poor tumour recognition and a highly immunosuppressive tumour microenvironment tme altered glycosylation is a hallmark of cancer often manifesting as incomplete synthesis of oglycans and increased branching of nglycans glycosylation can mask epitopes to antibodies recognition and suppress anticancer immunity my unit was the first to report that nglycans protect tumours from cart cells and that pharmacological inhibition of nglycosylation improves efficacy of cart cell therapy in solid malignancies with the aim of generating a single cell product able to safely offset multiple barriers of tumour resistance i propose to engineer cart cells to locally express an enzyme able to deglycosylate tumour and tme cells this goal will be achieved through the selection of a mutant able to deglycosylate the surface proteome of target cells to regulate its function in cart cells i plan to test different systems based on the use of specific promoters the inclusion of artificial mirna target sequences or the generation of a transmembrane variant a deep characterization of the selected product will be performed in mice reconstituted with a human haemopoietic system this model will allow to study the efficacy and safety of the proposed approach and to assess its ability to remodel the tme toward a proinflammatory state i believe that this project will have an immediate impact on cancer immunotherapy will fuel the development of antiviral approaches and will provide new technological platforms i have a deep knowledge of cart cell therapy and have established a great network in the field despite ambitious i believe i have the right skills and tools to make this project a reality
placebased innovation of cultural and creative industries in nonurban areas

the in situ project combines research and experimental actions to advance the innovationrelated practices capacities and potential of ccis based in nonurban areas of the eu a constituency of the cci sector that has grown in visibility and significance over the last decade in europe and internationally but which is still vulnerable due to the lagging attention of research and policy to its needs characteristics and potentials the project aims to advance understanding of the forms processes and governance of innovation involving cultural and creative industries ccis located in nonurban areas of europe and to advance the ability of nonurban ccis to act as drivers of innovation competitiveness and sustainability for the locales in which they are located in situ brings together leading approaches to investigating economic evolution and diversification a challengeoriented approach to processes of innovation nonurban placebased planning and development and creative industries entrepreneurship to investigate the situation of ccis in nonurban areas the project couples this with a pragmatic capacitybuilding programme to enable ccis to address some of the key issues of their communitiesregion and of our time the core defining aspect of in situ is the interlinking of research and practice through placebased in situ labs hubs for projects in 6 nonurban regions across europe located in portugal ireland iceland finland latvia and croatia involving both europewide research and placebased experimentation in situ will provide an indepth knowledge of the direct and indirect effects crosssectoral connections and spillovers innovative strategies and systems and needs of cci practitioners in nonurban areas complementary to this the project will assess and advance the multilevel innovation and culture policy and planning frameworks that contextualize and can enable this work
methodology of psychopedagogical big data and commercial video games procedures for the european skills agenda implementation

according to the importance of soft skills in the european skills agenda transversal skills in the document the eu has tackled this gap by working with competency and skills definition models such as entrecomp lifecomp and esco classification however there are still at least two important gaps between soft skills and both the education and the labour market high atomization and the absence of rigorous and affordable training and assessment methodsmegaskills is a project whose main objective is to help bridge these gaps between education and the labor market through the research and design of an innovative and affordable methodology for training and evaluating soft skills through 3 main research tasks to figure out how to 1 reach a consensus pact for soft skills taxonomy and normalization based on the manifest needs of industry and education 2 training and evaluation techniques through the use of the massive amount of data from the interactions of players with their favorite video games considering the very high penetration of video games among workingage citizens in europe and the use of ai and machine learning algorithms and 3 implement methodologies and educational designs that will build an affordable strategy for the new educationallabour paradigm at a european level thanks to this approach megaskills will intend to respond to at least six different actions within the european skills agendathe only way to address the gap between education key productive sectors and their skills in demand and at the same time to comply with several of the points of the european skills agenda is from a perspective that is all rigorously scientific multidisciplinary and disruptive as megaskills is for the megaskills consortium this disruptive approach must come from techniques and methodologies that can be both affordable and massive enough so that the impact on the labour and educational sectors is remarkable and sustainable both socially and economicall
a long duration and cuttingedge thermochemical heat storage and upgrading technology for heat and power applications

this project aims to develop and validate to reach trl 4 a novel thermochemical technology that not only can store midtemperature heat 250400 deg cthis project aims to develop and validate to reach trl 4 a novel thermochemical technology that not only can store heat at competitive cost and very high efficiency but also may upgrade that to considerably higher temperatures this way the technology enables the upgrade of mediumtemperature heat to drive hightemperature and more efficient power cycles eg supercritical the heat is stored in the form of chemical bonds making it suitable for a longduration and seasonal storage solution for power and heating applications this novel and outstanding heat storageupgrading concept offers some further important features that make it even more promising these are its i competitive costeffectiveness compared to other technologies due to its expected long lifespan and designoperation simplicity ii compatibility with a variety of heat sources solar collectors industrial waste heat electricity etc and power blocks upon the right material selection iii capability of continuous discharging with periodic charging as a requirement for many power cycles upon proper sizingdesign iv scalability up to severalhundred mwhs of capacity and storage duration from several days to even seasonal with minimal losses v no environmental impacts toxicity and human health issues and vi many more potential applications upon further and casespecific developments in the future the consortium consists of 9 partners from all corners of the eu including 3 universities 1 research center 2 smes 2 large enterprises and 1 ngo ensuring that all required expertise exists for the successful accomplishment of the project and future exploitation and also the partners optimally supplement each other the technology will be demonstrated in different designs and integrations at 5 kw heat capacity at the dlr laboratory
integrated design of the components of the energy system to plan the uptake of renewable energy sources an open source toolbox

gathering 22 partners from the eu norway switzerland and ukraine idesignres aims to provide public authorities and network operators with opensource toolboxes allowing to plan and to optimise the uptake of low and zero emission energy sources at regional national and european scales with these opensource tools idesignres provides latest multiphysics component energy models comprehensive energy system modelling in particular assembling of component models longterm multicarrier grid planning and optimisation of investment and operation idesignres embraces a new degree of openness transparency and accessibility to use energy system models and their components it delivers a harmonized data structure compatible with all modelling approaches ie standardized in a common modelling language idesignres relies on an already built database compliant with these standardized data formats based on this modelling and data infrastructure idesignres will develop a unique and innovative cloudhub platform to run any energy system model online this will facilitate research collaboration easier software testing and version control and increase computational performance open licenses cloud services and supercomputing for average users to demonstrate and validate the tools idesignres has five reallife cases two macro region cases north sea area and south east europe two industrial clusters basque and lombardy regions and one expansion case in ukraine the models and scenario results are combined in the final idesignres visualisation tools aimed to inform policy makers and grid operators the outcome is that the public and relevant authorities can design a renewable energy system entirely online with easily accessible suite of tools capable to model at high spatialtemporal resolutions subhourly nuts level2 regions to represent detail energy system physics and to assemble models with a high degree of modularity
woodderived hybrid particles for stabilized dispersions

aqueous particle dispersions are elemental to many aspects of everyday life from food and pharmaceuticals to construction materials however todays dispersion science faces a grand challenge in developing colloidal particles with outstanding functionality in a sustainable manner to enable societys transformation from oilbased economy to bioeconomy there is an urgent need to develop sophisticated biocompatible materials such as particle dispersions from biomassderived precursors through sustainable conversion routes current biobased alternatives to synthetic dispersions are entering the market rather slowly primarily because key technologies to achieve superior functionality to justify industrial adaptation of biobased polymers are lacking i will promote the findings of my fundamental erc cog project on hierarchical particles from two of the most abundant but underused biopolymers lignin and hemicelluloses partipersion will establish a green route to sophisticated hierarchical architectures hemicellulosecoated lignin particles utilizing abundant bioresources the project will lead to a breakthrough in colloid and interface science and contribute to more sustainable use of earths resources
feynman graph expansions for high precision

to an astonishing degree the laws of physics are described by the standard model of particle physics having discovered its final mito an astonishing degree the laws of physics are described by the standard model of particle physics having discovered its final missing piece the higgs boson cerns large hadron collider has now entered its highprecision phase challenging not only the sm but also our abilities to draw sufficiently precise predictions from it a formidable challenge will be to bring the accuracy of theoretical calculations to the percent level and if possible beyond there are various bottlenecks associated to the different ingredients entering these predictions an enormous challenge will be to improve the accuracy of partonic cross sections which describe the scattering of the protons constituent quarks and gluons in perturbative quantum chromo dynamics to reach the required precision we already now desire nexttonexttoleading order nnlo predictions for 2to3 processes nexttonnlo n3lo predictions for 2to2 processes and even n4lo predictions for 2to1 processes at the same time further improvements to n4lo will be required for the splitting functions which are needed for a systematic treatment of parton density functions with the high luminosity phase of the lhc commencing in 2029 we can expect however that predictions of even more complicated final states will be required it is clear that our current methods are not be up to the task this project aspires to fill this gap through a new methodology based on very recent advances i made in feynman graph theory and its applications to asymptotic expansions and infrared subtraction schemes this methodology will allow for the efficient automation of expansions around kinematic limits leading to new pathways to obtain reliable and systematically improvable approximations for scattering amplitudes and the cross sections to which they contribute which are currently out of reach