Dragon09/odtu_chatbot huggingface dataset:
fcaecc fellowship programme for talented researchers in cancer

the scientific foundation of the spanish association against cancer from now on fcaecc is a philanthropic private entity that aims to finance excellent cancer research in spain for the benefit of the general public and patients ranging from basic research to clinical application fcaecc is the entity that devotes the most funds to promote and support cancer research in spain in its strategic plan fcaecc states its firm commitment to finance the best cancer research in spain aiming at promoting talent stabilizing the professional career of researchers fostering the globalization of spanish cancer research and involving society fcaecc has a national fellowship programme that supports experienced researchers to develop their own research lines and currently is funding 525 cancer research projects worth 92 million eur which resulted in 316 publications in 2021 with an average impact factor of 8with aecc talent new fellowship programme fcaecc opens its fellowship programme for transnational mobility aiming to attract to spain the most talented experienced researchers from abroad aecc talent will contribute to improve prevention early diagnosis monitoring and treatment of cancer patients which are key intervention areas of the horizon europe mission on cancer aecc talent will fund 30 fellowships divided into two callshost organisations participating in the programme are accredited by fcaecc as excellent in cancer research by means of a rigorous assessment process that guarantees their quality impact and leadership in cancer research at national and international level fellows will have a wide choice of entities and multidisciplinary teams in which to carry out the project of their interest following a bottomup approach the 15 host organisations report a high number of international collaborations and participation in european and international projects and endorse the principles of the charter code for researchers
spreading open and inclusive literacy and soil culture through artistic practices and education

soilscape harnesses the power of cultural and creative industries ccis artists and civil society organisations csos to promote soil preservation across europe and beyond working with experts from the worlds of soil sciences arts decisionmaking and humanities this project coordinated by afes seeks to cultivate soil literacy and celebrate soils through creative approaches engaging citizens professionals on this journey soilscapes objectives include understanding humansoil relations building a network of more than 120 relevant actors in 8 countries onboarding at least 320 individuals from the society providing 1850000 as financial and technical support to csos ccis schools artists and institutions distributing 375000 as awards and 80 soil literacy certifications to inspiring initiatives and reaching international scales through unesco and coalition of action for 4 soil health to achieve these objectives soilscape uses a multilingual and multiactor approach focusing on cultivating artistic soil intelligence promoting contextbased soil literacy enhancing awareness through innovative communication strategies and a soil literacy portal organising 2 editions of national soil festivals across europe and extending its actions to 30 regions by 2028 the project unfolds through 4 key stages 1 contemplation consulting stakeholders to understand individual perception on soils arts and links with societal values investigating soil narratives and the potential of arts and artsbased methodologies to engage in soils 2 preparation developing peoplecentric transformative strategies including an artistic and creative international soil network 3 action conducting and monitoring the soilscape creative activities including the support to 28 artssoils initiatives led by third parties 4 sustainability validating and replicating the soilscape initiatives at large scale
decipher how mrnas are captured at specific subcellular locations to support local translation in neurons

brain function requires precise regulation of the neuronal proteome which involves localizing thousands of mrnas to neurites where specific subsets are translated at the required subcellular locations although local translation is wellestablished the mechanisms that ensure the capture and translation of specific mrnas at the correct subcellular location remain elusive a better understanding of this process is urgent since dysregulation of mrna localization and translation is emerging as a key pathological event in neurodegenerative diseases such as amyotrophic lateral sclerosis alsin rnaorg i aim to define at a molecular level how the coordination between mrna transport capture and local translation occurs to support neuronal functionrecent work from my lab and others has shown that multiple organelles interact with mrna and translational machinery this raises the exciting possibility that organelle interactions coordinate mrna distribution local capture and selective translation i have developed tools to visualize and manipulate organelle position and contacts at nanoscale resolution here i will leverage these tools and directly control mrna positioning to elucidate the importance of mrna capture in neuronal function and intervene in its dysregulation in alsin combination with livecell and superresolution imaging rnasequencing and proteomics this project will address the following key objectives1 resolve the subcellular distribution and dynamics of neuronal organellemrna contacts2 unravel the functions of organellemediated mrna capture at specific subcellular locations3 determine the role of dysregulated mrna capture in amyotrophic lateral sclerosisrnaorg will elucidate novel mechanisms on the subcellular capture and translation of specific mrnas in neurons and will provide new insights into the role of local mrna positioning in neuronal development physiology and pathology
environmental impact of genotoxicants

the eu2030 biodiversity strategy com2020380 aims to ensure europes biodiversity will be on the path to recovery by 2030 freshwater fish are among the taxa mostthreatened by extinction in europe with a decline proven in abundance and biomass in most common european freshwater fish speciesfor europes biodiversity to be on the path to recovery researchers environmental managers and policy makers must identify and mitigate environmental factors and anthropogenic pressures that impact freshwater fish populations chemical pressures are impacting 38 of european surface water among the 56 priority hazardous substances monitored in the euregulation in surface water more than one third of them are classified as carcinogenic or suspected to be carcinogenic for humans these substances may induce embryotoxicity abnormal development metabolic disorders and longterm initiation and promotion of carcinogenic pathways in fish species there is a need to ascertain what ecological risks result from the exposure of aquatic organisms to genotoxicants in the environment as well as a need to urgently develop innovative diagnostic tools to assess ecological risks in eu surface wateras proteins play a critical role in tumorigenesis oncoproteomics has become a growing field in medical cancer research in this project we aim to develop nextgeneration biomarkers for two european endemic freshwater fish species by leveraging emerging highthroughput proteomics methods through lab and field experiments we aim to identify toxicity pathways and relevant biomarkers in fish exposed to genotoxicants as well as relevant biomarker responses that are induced early before individuals survival is threatened this project will not only pioneer the use of diagnostic tools developed for medical research in the discipline of freshwater fish ecology but will also apply these tools in the field by measuring genotoxicant exposure of native fish populations in the rhone river basin
the impacts of climate protection on agricultural productivity and food security

the european unions goal of achieving climate neutrality by 2050 is crucial for transitioning to a lowcarbon economy however ambitious reductions in greenhouse gas emissions may lead to unintended consequences notably from current eu policies on one hand increasing food production for zero hunger sdg 2 can escalate greenhouse gas emissions responsible for about 34 of total anthropogenic emissions predictably direct carbon emissions from agriculture will rise in the coming decade yet mitigating these emissions especially in the short term may reduce production and raise food prices potentially limiting access especially in foodinsecure regions this could lead to increased poverty and stunting balancing emissions reduction with agricultural productivity and global food security is a critical challengeto avoid unintended negative consequences and optimize climate protection policy benefits interactions between different objectives must be considered in policy formulation the cliagrosec project aims to create a framework exploring synergies between agricultural productivity food security and climate protection objectives while acknowledging tradeoffs in multiobjective policy development this involves crafting comprehensive sustainable policies encompassing environmental economic and social dimensionsthe project has three specific objectiveselaborate on potential synergies and tradeoffs between climate protection policies agricultural productivity and food security propose a theoretical framework to identify negative externalities of climate protection policies within global climate agreementsdevelop a comprehensive integrated empirical model combining a global computable general equilibrium cge model with an agrienvironmental model assess the effectiveness of climate protection policies across countries and scales capturing the intricate dynamics of agricultural systems and their environmental implications
the heterogeneity of lewy bodies in single cells

parkinsons disease pd is the second most common neurodegenerative disease affecting millions worldwide pd pathophysiology is associated with protein aggregates called lewy bodies lbs and aggregation is impacted by cellular environment posttranslational modifications and genetic predispositions heterogeneity in the composition of lbs across the brain has consequences for neuronal cytotoxicity and although lbs are a main focus in pd research only a limited number of projects have explored their heterogeneity i will investigate lb heterogeneity at the single cell level for the first time enabled by technological developments of my host lab the mann group namely deep visual proteomics dvp dvp combines highresolution microscopy aiaided image analysis and ultrasensitive msbased proteomics to analyse the proteome in a spatiallyresolved manner i aim to identify proteins whose levels correlate with lb heterogeneity thereby classifying different lb phenotypes and finding tipping points in lb maturation that drive cell death i will first apply dvp to cell culture models overexpressing alphasynuclein a main component of lbs to investigate the composition of lbs and determine candidates promoting various types of lb phenotypes such candidates eg the already known tubulin polymerisation promoting protein tpppp25 will be expressed in cells to confirm effects on the lb phenotype in parallel i will apply dvp to human brain tissue to identify differences in aggregates across stages of the disease and to distinguish between healthy and sick cells within the same tissuethis analysis will provide unique insights into the progression of the disease and may yield new therapeutic candidates
virtual design of flexoelectric sensor for electronic skin

soft electronic devices are indispensable for the development of artificial skin due to their high stretchability and sensing functionality conventionally to mimic touch and temperature sensing of mechanoreceptors and thermoreceptors compliant structural design accompanied with signal transduction mechanism such as piezoresistive capacitive piezoelectric pyroelectric sensing have been utilized so far the design of these pressure sensors requires highly flexible and robust electrical properties of materials as active and supporting components in addition strategically engineered microstructure is employed to enhance the sensing performance in this spirit flexoelectric material which relates straingradient and electrical polarization emerges as a naturally suitable candidates for flexible pressure sensors the straingradientinduced polarization does not only distinguish flexoelectricity from the commonly used piezoelectricity but also widen the choice of electromechanical coupling materials especially leadfree and biocompatible materials that are crucial for the development of biomedical devices furthermore flexoelectric effect exhibits sizedependent behavior particularly at submicron and nanoscale so that proper design of microstructure can open an opportunity to a new type of pressure sensor therefore this project aims to propose a novel design for electronic skin eskin based on flexoelectric effect specifically a comprehensive virtual design framework including simulation characterization and experimental testing of flexoelectricbased sensor will be employed to evaluate key parameters such as sensitivity limit of detection linearity response time and power consumption
dynamical recurrent visual perceiver

reallife applications of computer vision often require highquality visual sensors with current technology such sensors are expensive empirical evidence from our ercfunded research of biological vision suggests that eye motion enhances recognition capabilities beyond what could be expected if the eye was functioning as a static camera motivated by these findings here we aim to perform the major computer vision tasks required for many reallife applications including segmentation classification and identification with lowresolution cameras the idea is to use a series of lowresolution frames from a moving camera rather than using a single highresolution image this novel algorithm termed here drvis can be implemented in software or hardware unlike existing solutions that use multiple frames to reconstruct a high resolution image from low resolution ones drvis does not need to learn all the particularities needed for reconstruction instead it focuses on extracting the necessary features per the given task the goals of the poc project are to scale up and diversify our current software system implement the system in hardware and demonstrate its performance in field conditions and develop the ipr strategy and explore the commercialization potential of our solution we expect it will be applicable to a wide spectrum of image processing tasks in settings where sensor quality is low but multiple time samples are available including smart agriculture drone navigation and visual aid devices
a new look at prostitution in medieval europe exploring the potential of ancient pathogen genomics with individuals buried in red light districts

sexwarc contributes to a paradigm shift in the archaeology of prostitution the discipline has thus far mainly been limited to a description of the structural features of which brothels are constituted but struggles to make meaningful observations when it comes to the people who have worked in these environments this project aims to put female sex workers back at the centre of our scientific work by focussing on human remains as a new source of information for the study of past sex workthe main objective is to get a grip on the health and living conditions of these women in the middle ages i will do this by combining for the very first time recent advances in ancient dna research of pathogens with some unique skeletal populations excavated in identified red light districts of medieval cities in the county of flandersas a crossover between the archaeology of sex work and ancient pathogen genomics i will integrate both the division of medieval archaeology and the archaeo and paleogenetics group at the university of tübingen under the supervision of prof dr natascha mehler and mentoring of prof dr cosimo posth globally acknowledged as experts in their respective domains this action will allow to establish myself as an independent scholar with a highly strategic profile and as a future leader of an interdisciplinary research group in historical archaeology
dealiix an exascale framework for digital twins of the human body

dealiix an exascale framework for digital twins of the human body is a pioneering project aimed at developing a scalable highperformance computational platform using the dealii library to create accurate digital twins of human organs with emphasis on the human brain this framework will leverage exascale computing capabilities and existing lighthouse applications to simulate complex biological processes in realtime aiding in personalized medicine and advancing the diagnosis and treatment strategies of neurological disorders the computational complexity to solve the underlying mathematical models has previously prevented the simulation knowledge from being translated into clinical practice by integrating cuttingedge hpc technologies with multiphysics and multidisciplinary approaches dealiix will deliver unprecedented computational efficiency and fidelity in biological modeling the project represents a significant leap toward the future of medical diagnostics and treatment planning offering a robust tool for researchers and clinicians alike
rational nanoparticle design for efficient transmucosal crispr delivery in cystic fibrosis crisprgels

cystic fibrosis cf is the most common genetic lung disease monogenic autosomal recessive disorder worldwide and currently there is no cure the emergence of powerful gene editing tools like crisprcas clustered regularly interspaced short palindromic repeatsassociated protein 9 now provides the opportunity to correct the diseasecausing mutations which can potentially cure cf the present research project proposes the development of coremultishell nanogels ngs yielding efficient transmucosal delivery of crisprbased gene editing tools which can address the challenges for treatment of cf at european level this project brings together a talented highly motivated and young researcher dr krishan kumar with background in polymer chemistry phase transition temperatures understanding structure of colloids biomacromolecular interactions and protein science structural stability immobilization enzymatic activity and an innovative institute polymat in developing biomedical solutions for treating cf diseases based on nanogels mediated controlled release of crisprcas9 complex crisprgels will focus on advancing the young researchers career through development and manufacture stages of nonviral gene delivery systems facilitating the curative gene editing approaches for treatment of cf patients the host supervisor prof marcelo caldern is globally recognized researcher working in area of transmucosal delivery using nanogels ngs the behavior and interactions of the ngs will be systematically investigated in cf patientderived sputum and cf bronchial epithelial models most efficient ngs will be validated on preindustrial scale multidisciplinary expertise required for crisprgels will be complemented by highly experienced research teams responsive polymer therapeutics group rptg translational organ models group tomg and imed company
twinning for excellence in reliable electronics

reliable electronic systems are crucial in a wide range of applications such as space missions avionics automotive smart industry medicine banking nuclear power plants high energy physics research with the introduction of advanced semiconductor technologies the design of reliable electronic systems has become more challenging requiring novel analysis and design methods and tools the ultimate goal of twinrelect project is to boost the scientific and innovation capacity of uth in the design of reliable electronic systems through strategic networking with three advanced partners ihp institute for high performance microelectronics from germany national center for scientific research cnrs from france and university of manchester from united kingdom the twinrelect collaboration will employ a set of actions grouped into five main components i joint exploratory research aimed at the development of a novel tool for simulation of reliability effects and design of reliable integrated circuits ii knowledge transfer through staff exchanges joint training experiments supervision of early stage researchers and organization of training schools iii knowledge transfer in relation to research management and administration iv enhancement of networking capacity through organization or workshops business events special sessions at conferences webinars with related projects and international symposium and v establishment of conditions for long term collaboration between uth and advanced partners as well as interested stakeholders
metabolic regulation of the skeletal stem cell niche

the continued health of many of our organs including the skeleton relies on the function of specialized stem cells these stem cells reside in niches that support their longterm maintenance disruption of the niche due to aging injury or genetic mutations can lead to declines in stem cells and a failure to maintain and repair tissues compared to our understanding of the stem cells that maintain and repair our skeleton we know much less about the cell types that constitute their niche my prior largescale genomics studies have uncovered a novel niche cell type for the skeleton intriguingly these niche cells are defined by a unique metabolic profile highlighting in particular enzymes for phenylalanine phe tyrosine tyr metabolism and glycogen synthesis traditionally it has been thought that phetyr are degraded primarily in the liver and the skeletal malformations in patients with phenylketonuria mutation in pah tyrosinemia iiii mutations in fah tat hpd and alkaptonuria aka black bone disease mutation in hgd has been interpreted as the results of systemic intoxication by accumulated metabolites my dogmashattering result suggests that local regulation of phetyr degradation might be a critical strategy to support the skeleton i will establish a research group that leverages the powerful genomic genetic and highresolution imaging strengths of zebrafish to test the requirements of niche cells in skeletal stem cells homeostasis and the roles of metabolism in stem cell maintenance findings from my proposed studies will inform future therapies aimed at correcting metabolic diseases and restoring stem cell function and skeletal health by modulating the niche