Dragon09/odtu_chatbot huggingface dataset:
unique collaborative ecosystem and programme for promoting the transatlantic cooperation in ngi technologies

the eu the us and canada share the values of democracy human rights the rule of law and economic and political freedom and have overlapping foreign policy and security concerns close cooperation and strategic relations with the us and canada remain a priority for the euthe next generation internet ngi initiative supports this vision of building bridges internationally especially with the us and canada in fact there have been many initiatives since 2016 focused on enhancing collaboration and cooperation in the development of ngi technologies services and standards with the us andor canada the advancement of emerging topics for the eu ngi and corresponding us and canadian programmes such trust and data sovereignty digital identity internet architecture renovation decentralised technologies and standards it is of outmost importance to shape the future internetin this context ngi sargassos mission is to catalyse transatlantic collaboration on the development and experimentation of new ideas implementation of prototypes and contribution to standards and opensource communities on technology trends with the potential to reshape tomorrows ngi technologies and services the project will run five open calls for proposals attracting 300 eu us andor canada teams working on emerging topics for the next generation internet and will support up to 96 projects that will be benefited from both equityfree funding and capacity building services in a 9month programmethe consortium is led by the european science foundation an eu association with a network of over 40000 experts across all scientific disciplines and over 83 countries and counts with the support of mwcb an ecosystem builder driving the digital advancement of society sploro whose team has been part of different ngi projects including the euus fellowship programme ngi explorers and australo leader of the community building in ngi explorers and think nexus as core partners
towards an ecosystem of usercentric devices and services for multisport training and remote healthcare enabled by an artificial intelligencebased network of sensors

eutrains aims to reinforce the supply chain on sensors for biomechanics and cardiovascular system realtime monitoring targeting applications in the fields of fitness and healthcare it leverages from the strength of eu digital microsystem and design to support a 100 madeineurope supply chain of solutions which encompass smarttextile integration as well as advanced aibased edgecloud data processingin details the following outcomes are foreseen textile integrated electronic systems for realtime monitoring of hearth respiratory and movement parameters ontheair and inwater through an interdisciplinary approach semiconductor technologies which allow the reuse of micronano systems both in the sports and in the healthcare sectors miniaturized devices allowing the capturing of biochemical parameters able to withstand harsh ambient conditions such as salt fogs chlorine detergents high and low temperatures etcthe following key activities are targeted development prototyping and demonstration of versatile sensors with edge ai features for improved precision and reliability that can also be integrated in textiles as well as in smart wearable wristwatches and in sport equipment and gears targeting also underwater applications cloudedge artificial intelligence combined approaches for reliable diagnosis of body parameters this will comprise sensors selflearning remote update multisensing approaches based on sensor arrays novel materials that support electronics printing in textiles with stretchability and selfhealing capabilitiessocietal benefits are foreseen in the transition to a healthier lifestyle by promoting regular physical activity through affordable tools and services for a large audience including people with disabilities moreover this will impact the smartremotehealthcare sector which will benefit of the availability of lowcost microfabricated solutions for intelligent versatile connected body sensors
the insulabody loop for neural control of gut physiology

the brain and body are in a continuous dialog our brains constantly receive sensory information from within our body as well as from the external environment and then use it to regulate bodily function brainbody communication is essential for our physical and mental health yet little is known about how it is achieved at the neurobiological level a large corpus of work implicates the insular cortex as a central node in the brains interoceptive network current models suggest that insular cortex integrates internal and external sensory information to regulate bodily physiology yet direct experimental evidence has been scarce i propose a research program that focuses on the insular cortex as part of a dynamic loop with the gastrointestinal system which regulates peripheral metabolic function and feeding behaviour two fundamental questions form the core of this proposal 1 how do the sight smell and taste of a savoury dish or a sweet dessert enable our brains to predict the postingestive nutrients they will supply 2 how are these predictions relayed to our body to preemptively prepare it for consumption eg by inducing salivation and insulin release to answer these questions we need to understand both cortical predictive computations as well as peripheral physiology i therefore propose to build on my expertise and use an interdisciplinary approach combining cuttingedge neuroscience and computational methods with recordings and optogenetic control of peripheral physiology this will reveal 1 how insular cortex represents internal sensations 2 how insular cortex forms associations between internal and external sensory information and 3 how these associations are relayed to the body to maintain homeostasis this study will provide a conceptual and methodological foundation for future elucidation of how different internal sensory modalities act together within the brainbody loop to maintain our physical and emotional health
oral oxytocin for abdominal pain

chronic abdominal pain is a widespread debilitating condition commonly associated with gastrointestinal disorders such as irritable bowel syndrome ibs and inflammatory bowel diseases ibd ibs and ibd affect more than 10 of the global population leaving a severe and steadily growing socioeconomic burden on society 115 billionyear in europe in direct and indirect health care costs adequate pain management for these conditions is imperative but remains challenging since classical analgesics are poorly effective associated with adverse effects and can even exacerbate disease progressionin this project we will advance a new class of gutstable peptide analgesics to target abdominal pain at its origin in the gut this represents a highly innovative treatment strategy with a large safety window due to its gutspecific action and negligible risk of systemic offtarget effects it also addresses a longstanding problem in the peptide therapeutics industry namely the lack of oral peptide drugs the objective of this project is to optimise our patented lead compounds towards oral drug candidates and generate robust and supporting preclinical data for clinical translation the proofofconcept data will then be used to engage with industry partners and other supporters to advance these drug candidates into the clinic for the treatment of chronic abdominal pain our gutspecific treatment approach along with this new class of analgesics could induce a highly desired paradigm shift in how to treat chronic abdominal pain and gastrointestinal disorders an area with unprecedented unmet medical need this could benefit millions of people worldwide improve their quality of life and help reduce the substantial socioeconomic burden that chronic abdominal pain has on society
biosensing by sequencebased activity inference

the ability of cells to sense and respond to signals is an essential requirement of life genetically encoded biosensors meet this need by detecting for example chemicals and triggering gene expression in response this concept is used across the life sciences to sense molecules in basic research diagnostics and treatment crucially biosensors can be used to isolate and engineer microbes that sustainably produce valueadded chemicals and thus play a key role in the transition to a circular economy however native biosensors are mostly unfit for synthetic applications in terms of molecules and concentrations they respond to moreover little is known about the relationship between biosensor sequence and resulting function which prohibits rational biosensor engineering and enforces tedious often unsuccessful trialanderror approachesi propose to build a pipeline for the rational engineering of biosensors with tailored sensory properties to overcome these limitations building upon an ultrahighthroughput dnarecording technique we have recently invented we will generate hitherto inaccessible datasets linking over 108 transcriptional and translational biosensor sequences with their sensory properties and use these data to train deep learning models that infer biosensor function directly from sequence this will enable straightforward biosensor design which we will capitalize on to build a versatile biosensing platform to specifically detect and discriminate molecules from three metabolic compound classes with high potential for biobased production finally we will apply designed biosensors to engineer new enzymes for co2fixation and build dynamic metabolic controllers to obtain superior bacterial strains for the production of flavors and pharmaceuticals our novel datadriven approach will break new grounds in biosensor engineering through synergies between synthetic biology and artificial intelligence paving the way to novel sustainable bioprocesses
novel health care strategies for melanoma in children adolescents and young adults

in childhood adolescence and young adults caya melanoma is understudied and nonexisting tailored clinical guidelines and standardized approaches lead to a very low diagnostic accuracy the melcaya project aims to understand risk factors and determinants of melanoma to improve the prevention diagnosis and prognosis of melanomas in cayas through a strong international consortium with experts from 10 countries in different disciplines eg oncology paediatrics ethics policy making and sectors eg academic centers smes hospitals patient associations melcaya will work on different approaches 1 by integrating existing reference european cohorts and registries studies of genetic and environmental risk factors and progression of melanoma in caya will be performed through different omic methods and a novel taxonomy of caya melanoma will be generated 2 melcaya will also develop imagebased robust and trustworthy machine learning tools and a paneuropean secondopinion platform for better diagnosis specifically designed for caya 3 moreover the validation of minimally and noninvasive disruptive tools based on artificial intelligence and volatilomics detection from exhaled breath and skin will lead to earlier detection and more accurate prognosis of melanoma in caya 4 finally through the evidence gathered melcaya will design and implement public health strategies and will actively involve patients and the general population the results of melcaya will maximize its impact by making its data and results accessible and reusable through integration into uncaneu this action is part of the cancer mission cluster of projects on understanding
city buzz quantity quality and variety implications of the urban environment

this research project aims to understand the changing landscape of cities these are cities where facetoface interactions happen less around office water coolers and more on the streets where individuals not only produce differently by location but also have heterogeneous consumption and where beyond the adoption of working from home the transformation of work involves a reorganisation of firms establishments and hierarchies across locationsto capture facetoface interactions accurately we use anonymised cellphone records to identify spatial and temporal overlaps among users who also have phone conversations by combining location and call data meaningful interactions are distinguished from passing strangers while quantifying social connectivity and distinguishing between strong and weak ties the project examines variations in quantity quality and diversity of facetoface interactions across spatial contexts it isolates the effects of the urban environment from personal characteristics by studying individual changes following shocksthe project also investigates consumption differences across locations it uses anonymised credit card data to examine the quantity quality and variety of consumption venues going beyond locally available venues to explore how individuals utilise them and accounting for endogenous amenities and location choices we consider coconsumption evidence residence and job information to understand leisure interactions among neighbours coworkers and friendsfinally we explore changes in the hierarchical organisation of firms across space using matched employeremployee data and a model of cities and hierarchies we investigate how firms organise establishments and managerial hierarchies across locations moreover we examine the relationship between systematic differences in firms hierarchies across cities and workers progression to explain the citysize earnings premium
bioinformatics for genomics in malta

biogemt will merge the strengths of the university of malta um in ict and genomics by hosting an expert bioinformatician and team within the centre for molecular medicine and biobanking that will forge collaborations with existing highly specialised molecular genetics research groups the goal is for um to sustainably develop the field of bioinformatics and the knowledge base and machine learning skills required to translate patient derived multiomic and clinical data into a better understanding of disease the advancements made in high throughput omic technologies are locally hampered by a lack of bioinformaticians there are benefits to rapidly developing bioinformatics in malta the populations genetic background and availability of large families is advantageous in elucidating the genetic basis of disease the um has expertise in biobanking genetics genomics and epidemiological research enabled through strong ties with mater dei hospital biogemt complements and builds on previous investments erdf twinning local ri funds used to train researchers build specialised labs and set up highly phenotyped diseaseoriented sample collections with multiomic data one with 2000 whole genomes and rnaseq data sets bioinformaticians would unlock the full potential of ongoing studies helping to overcome the problematic lack of genetic data from populations other than those of northern european origin biogemt would boost the international attractiveness innovation and ability of the um to compete successfully for international research funding including imi horizon europe charity foundations and industrial grants by creating a highly specialised bioinformatics centre in southern europe in the long term this will increase the attractiveness of malta to bioinformatics companies in line with the national smart specialisation strategy to expand into ict for health counteract brain drain generate jobs and enable collaboration with untapped noneu regions
brain endothelium targeted gene therapy to improve a clearance in alzheimers disease

alzheimer disease ad is the most common cause of dementia 6080 of cases with a prevalence near 50 million people there is no cure available and there are only two classes of approved drugs that are effective in treat some of the cognitive symptoms and potentially delay the clinical decline despite the considerable progress achieved in the research of best performing diseasemodifying agents the main clinical challenge remains the accomplishment of an efficient and safe therapeutic option that can arrest the disease progression and prevent cognitive failure in this project i am proposing an innovative approach to improve ad pathophysiology by targeting the brain endothelium to improve the amyloid a clearance using gene therapy i will use superselective nanocarriers to carry relevant genes for the enhancement of the a clearance mechanism these nanocarriers will be functionalised to allow the specific targeting of brain endothelial cells and to increase its potency to deliver the therapeutic gene into these cells this project will combine for the first time the use of superselective binding strategies and gene therapy for brain endothelium targeting and modulation in the context of ad overall i will develop an innovative therapy for ad treatment capable of reaching the bbb in a noninvasive way being able to target the brain endothelium overcome the defective a transendothelial clearance and potentially arrest the disease progression and prevent cognitive failure therefore this project will reach a global impact by substantially contributing with a novel avenue to change the clinical course of ad pathogenesis
inositol pyrophosphates in phosphate homeostasis increasing nutrition value in rice

phosphorus p is one of the most important molecules having a role in almost every aspect of plant metabolism so a constant supply of p and its efficient use as pi are necessary to sustain plant growth development and yield however in most of the agricultural lands pi is poorly available to plants in order to overcome the consequences of pi deficiency farmers have adopted excessive and routine application of p fertilizers causing serious impacts on the environment there are two main concerns regarding the excessive use of p fertilizers on one hand erosion by water and wind results in p runoff into open water bodies causing a major threat to planetary health on the other hand p deposits represent a limited resource on our planet additionally some p forms within the plant such as phytate are crucial to determine micronutrient availability for the human nutrition and animal feed therefore there is an urgent need to understand the functional aspects of pi sensing transport signaling and remobilization and thus it is imperative to develop crops with enhanced pue p use efficiency and micronutrient availability to support a more sustainable agriculture system although rice counts for the thirdmost produced cereal crop in the world it is limited to have only 25 pue providing an enormous scope for improvement in p nutrition in this line we propose to investigate the synthesis and physiological roles of inositol pyrophosphates ppinsps in pi signaling and homeostasis to improve the nutritional value of rice the proposed research will help to better understand how ppinsps control pue and will provide the knowledge to reduce phytate content in rice seeds thereby increasing micronutrient bioavailability without compromising plant immunity health and yield in short the discoveries will help to enhance pue preserve pdeposits mitigate the detrimental consequences of excessive pfertilization and improve the nutritional value of rice
photonhub factory for nextgeneration photonics innovation support boosting european industrial competitiveness and securing technological sovereignty

phactory is a unique paneuropean consortium operating as a onestopshop virtual factory for photonics innovation support of european industry phactory brings together over 30 partners representing europes top competence centers in photonics together the phactory partners offer open streamlined access to the full spectrum of photonics technologies expertise and supply chain activities from trl27 including pilot lines and pic foundries combined with specialist partners in business investment intellectual property and eu manufacturing support services to maximize the commercial impact from the project phactorys ambitious work plan builds on the proven track record of over 20 years of successful collaboration between the consortium partners in previous similar eu projects and aims to go well beyond the current stateoftheart in terms of its impact phactory will reach out broadly to european industry especially smes startups and scaling companies predominantly as first users and early adopters to generate a critical mass of 125 carefully selected support cases with the highest potential for commercial impact phactory will work closely with the selected support cases providing deep technology support interventions for trl acceleration through intensive crossborder collaborative innovation projects combined with tailored business supports to accelerate the investment readiness levels irl of the supported companies as a result phactory expects to achieve a quantified impact of at least 1250 new eu jobs 937m in new company revenues and 190m in new venture capital on aggregate within the supported companies directly related to the delivered phactory innovation supports the phactory project will simultaneously strengthen the european photonics innovation ecosystem with more complete and mature value chains linked to eu manufacturing which are integrated into the photonhub association for sustainability of the innovation support services
heterogeneitiesguided alloy design by and for 4d printing

superior highperformance materials and co2free production technologies are key enablers to solving europes current and future societal challenges 1 in this context additive manufacturing am as one of the disruptive green production technologies of our time is expected to become a key manufacturing technology in the sustainable society of the future 2however alloys specifically designed for am are rarely available which prohibits am from reaching its full potential in contrast to conventional alloys and processing alloys processed by am are highly microstructurally heterogeneous it is the aim of heterogenius4d to use the processinherent conditions of highly precise bottomup am approach to tailor these heterogeneous structures eg grainsphases and their boundaries and orientations chemical gradients etc locally and spatially on various length scales this is the basis for the novel design concept of heterogeneitiesguided alloy design for am the potential to print local microstructures and properties in am adds a 4th dimension to the design of 3d printed components ie enables 4d printingamprocessed metals with increasing degree of heterogeneity from pure element over solid solutions with chemical gradients to multiphase alloys with further phases and gradients are studied systematically the processstructurepropertiesperformance linkages are identified and quantified by combining highthroughput material synthesis using extreme highspeed laser material deposition and characterization with physicsbased simulation tools enabling a comprehensive integrated computational materials engineering icme framework the generated data serves as a basis for sophisticated datadriven machine learning ml materials modelling and enables the establishment of an experimentsicmeml optimal design approach for metal am finally the concept of heterogeneitiesguided alloy design is generalised and transferred to graded components