Dragon09/odtu_chatbot huggingface dataset:
boryl radicalsbased strainrelease startegies for the divergent assembly of polyfunctionalised 3d building blocks

borylated molecules are some of the most used tools to aid molecular construction in both academia and industry generally via the nobel prize winning suzukimiyaura crosscoupling the invention of methods to form cb bonds is of strategic importance to discover and evolve molecules with direct implications on our lives central to this quest is designing synthetic strategies able to explore novel areas of chemical space as the pharmaceutical sector is now aware of the greater clinical success of molecules with 3d architectures developing methods able to assemble 3dshaped and saturated building blocks is a topic of continuous scientific endeavour the bicyclo111pentyl motif has been identified as a valuable bioisotere to replace flat 2d aromatics and improve the potency of lead molecules however difficulties in preparing and modifying this structural element have severely limited its use in synthesis there is an urgent need to develop novel methods that can effectively manipulate and introduce this motif into organic compoundsthis project seeks to substantially expand the fields of photocatalysis and borylradicals by introducing the concept of borylation by strainrelease a novel reactivity that explores the unprecedented ability of borylradicals to react with 111propellane and enable a unique preparation of polyfunctionalized bicyclo111pentanes this reactivity will allow the modular and divergent 1step construction of many important borylated 3dbuilding blocks that cannot be prepared by any other methodthis research capitalizes on recent developments of the host group that has disclosed a novel way to generate and utilise boryl radicals and has also experience in radical strainreleasethe completion of such an innovative and ambitious project at rwth aachen university will be facilitated by generating transferring sharing and disseminating knowledge and will enhance my future career following the training plan envisioned
categorical homological and noncommutative methods in geometry

this proposal is primarily interested in algebraic geometry a field that underpins geometric intuition with the precision brought about by calculation from algebra the algebraic information of an algebraic variety the set of common zeros of polynomial equations is packaged in sheaves and organized in categories which makes it possible to study these objects by importing the tools of homological and noncommutative algebra this categorical approach is natural for many of the current leading questions in mirror symmetry birational geometry representation theory and theoretical physics because it serves as a bridge between the geometric and algebraic language it is also fundamental as many properties and even classification results are not possible without it the proposal is deeply interdisciplinary and it connects broad areas of algebra and geometry it naturally splits into three parts the first aims to investigate one of the most fundamental properties of curves namely contractibility with noncommutative deformation theory it will generalize classical results using modern language at the same time producing many new explicit examples of rational curves in threefolds linking contractibility and noncommutative algebra will bring deep consequences for the birational and enumerative geometry of calabiyau varieties advancing areas of string theorythe second part studies surfaces with mild positive curvature fano but with ineffective anticanonical bundle the main objective is to prove a mirror theorem packaging physical information with tools of homological algebra the new heuristics definitions and techniques will open up an avenue to investigate higher dimensional settingsthe third part involves reconstructing varieties from associated categorical data i will tackle some hard open cases developing new tools and combining them with classical methods
novel drug for dry age related macular degeneration

ophtimedrx is an ophthalmic drug development startup company led by a team of exceptional women physicians and scientists led by dr dana rabinovich ophtimedrx is developing a novel drug for treating dry agerelated macular degeneration amd a leading cause of vision loss there is no available treatment for dry amd which affects 87 of the population and a further 2 million diagnosed yearly the occurrence of amd steadily increases with age affecting 2 of the population at age 40 and 20 of people over 75 our drug candidate delivered by intravitreal ivt injection in a clinic setting without hospitalization targets cellular aging termed cell senescence our product addresses the underlying cause of dry amd allowing for early intervention targeting the disease at early stages will halt or significantly slow dry amd progression preserving vision and maintaining quality of life we are currently performing preclinical rd studies and plan to be ready for phase i clinical trials by the end of 2024 a crucial step toward clinical trials is conducting a preinvestigational new drug ind meeting with the fda and a scientific advice meeting with ema officials these meetings are an opportunity to gain the agencys feedback on the design of the proposed nonclinical and clinical studies additionally these meetings will help us determine the budget and timeline for transitioning towards phase i clinical trials as well as set a goal for the next fundraising round the financial contribution of this grant will go towards consultant fees a specialized regulatory firm and fdaema fees in addition as a new ceo i would greatly benefit from the mentoring and coaching provided by eics business acceleration services which will help me improve my professional skill set particularly in investor relations and assist me with my various management and leadership challenges
inequalityaware market design

policymakers often introduce rules constraining transactions in individual marketssuch as rent controlor even choose to distribute scarce resources by circumventing markets completely as is frequently the case for health care or transit yet traditional economic intuition opposes these sorts of policies becauseunlike wellfunctioning marketsthey introduce allocative inefficiencyin this project i will explore the optimal design of marketplaces in the presence of underlying inequalities between participants developing a theory of inequalityaware market design imd my approach is to deploy a mechanismdesign framework that identifies the optimal way to structure the market in the baseline framework the designer maximizes a welfare function whose welfare weights reflect her redistributive preferences induced by the inequalities between participants market participants may have private information both about their willingness to trade and their welfare weightsresearch will focus on testing the validity and scope of the main hypothesis when inequalities are sufficiently pronounced and can be detected based on agents behavior in the market it becomes optimal to sacrifice allocative efficiency to achieve a more desirable split of surplus for example optimal market designs may involve inefficient rationinginequalityaware market design provides a novel way to address the growing problem of inequality in marketdesign settings the redistributive objective distinguishes this theory from the traditional mechanismdesign literature that has focused predominantly on efficiency and revenue as design goals the focus on optimal allocation rules in a single marketplace complements the publicfinance approach to redistribution through the tax system imd provides policy guidance by explaining whether and how policymakers concerned about inequality should resort to distortionary market interventions
the cosmic web from erosita and galaxy surveys synergy

the cosmic web cw is a complex network of structures composed of galaxies dark matter and gas formed of galaxy clusters connected by filaments lowmass groups and largescale superclusters have yet to find a place in the context of the cw the best way to trace the cw is to use optical galaxy surveys to detect the filaments and xray data to detect the hot gas of clusters the detection of groups and superclusters requires highsensitivity xray instruments due to the low density of their gas content and has so far been very difficult the new xray telescope erosita has however produced xray data of unprecedented sensitivity which allow the discovery of thousands of groups and hundreds of superclusters erosita opened for the first time the possibility for statistical studies of these structures in the context of the cw my goal is to exploit the synergy between erosita and galaxy surveys to shine new light on the place that groups and superclusters occupy in the cw this study will improve our understanding of how filaments channel accretion onto groups and will show how a physical definition for superclusters whose definition has so far been empirical can be achieved in the cw context the study of the cw is entering a phase of increased interest thanks to recent widearea galaxy surveys and new xray data investigations like this project are those that will pave the way for future experiments eg euclid athena this research will provide a significant advancement to our understanding of the cw structure formation and galaxy evolution with this research i will gain deep insight on how to integrate xray and optical data in the context of a large collaboration this project will prepare me to better deal with the outcome expected from future galaxy surveys and xray telescopes and will make me more suited to become a group leader at an european institution
revolutionising allergies diagnostics with the next generation of ultrasensitive highly multiplexed diagnostic tests based on micropearls

the who predicts that half of the european population will suffer from allergies allergies are a growing burden for our society our healthcare system and companies that have to take staff off work due to disabling symptomsthanks to fluorescent pearls and the discovery of quantum plates nexdot is developing a highly multiplexed diagnostic test that will allow to assay ige on 500 allergens and up to 1000 at once using only one drop of blood this innovation will revolutionize the way allergies are treated by reducing drastically the time to diagnostic and its associated cost x1020 reductionour technology could also be extended to serology tests for detection of patients antibodies against infectious agents or cancer markers it can be extended for global health for the easy and costeffective detection of antigens as infectious or toxic agents in human animals or environment for global health or food for industry
motorized nanomachines fundamentals innovations applications

monalisa a pioneering european consortium is at the forefront of artificial molecular machine research setting the stage for breakthroughs in chemical synthesis nanotechnology medical treatment and smart materials building on the foundational work recognised by the 2016 nobel prize in chemistry monalisa aims to make groundbreaking discoveries in the design and functional control of molecular machines that will lead to first demonstrations with practical relevance at the heart of monalisa is an innovative training programme fifteen doctoral candidates will receive comprehensive mentoring and training to become future leaders in the field the programme is designed to foster not only academic excellence but also entrepreneurial skills enabling these professionals to translate scientific breakthroughs into innovations and support evidencebased decisionmaking the strength of monalisa lies in its joint vision and collaborative framework bringing together top scientists including four nobel laureates prestigious institutions and a wide range of industry partners the nonacademic support ranges from dynamic smes to large global players supported by leading organisations that act as multipliers fostering new programmes and partnerships looking to the future monalisa is committed to developing sustainable educational structures that integrate the nonacademic sector to cultivate skills essential for the academic and nonacademic workplaces of the 21st century this initiative will increase collaboration research intensity and innovation capacity within the european chemistry ecosystem in doing so monalisa is poised to secure europes leadership in science and technology driving economic growth and societal benefits
potentials of agroecological practices in east africa with a focus on circular waterenergynutrient systems

praectice will provide a novel agroecology indicator set for east africa aimed at helping smallholder farmers in their agroecological transition the project goes beyond the existing indicator frameworks by putting the concept into action with a decision support tool for agroecology advisors supporting the selection of the best suited combination of agroecological practices in a local context in addition it puts a focus on circular waterenergynutrient systems of integrated aquaagriculture an practice with high potential for efficient farming with minimal climate impacts which has not been sufficiently explored in previous indicator work through a multistakeholder approach new insight on agroecological practices in east africa will be gathered to inform on existing successful practices as well as the barriers and drivers of east african smallholder farmers this insight will help develop an indicator framework for agroecology which while building on existing frameworks is adapted to the east african context and captures integrated aquaagriculture practices in detail the praectice decision support tool will then at the farm level help assess environmental and socioeconomic impacts with a particular focus on impacts on climate change mitigation and adaptation as well as financial viability the tool will be validated in three living labs situated in kenya uganda and tanzania covering different integrated aquaagriculture farming setups knowledge sharing activities through trainings student exchanges and events ensure the dissemination of results across east africa and between au and eu to reach practitioners at every level a cascade training mechanism with a trainthetrainer course will help agroecology advisors train farming representatives at the local level who then will help the farmers in their agroecological transition policy recommendations for au and eu policies will round off the project
sustainable intelligent management of indoor air quality for the culture and creative industries

climate transition is imposed to all sectors of the eu economy including cci especially through more efficient use of resources amongst ccis galleries libraries archives and museums glams require large quantities of energy for controlling volatile organic compounds vocs nitrogen oxides nox hydrogen sulfide h2s and humidity for cultural heritage ch artifacts conservation due to the absence of smart and efficient indoor air quality iaq control technologiessimiacci improves traditional iaq solutions such as ch storageshowcases conditioning heating ventilation and air conditioning hvac by developing a portfolio of innovative solutions reducing related energy demand by 3050 and extent ch conservation time simiacci will demonstrate i metal organic framework mofs adsorbents to efficiently capture noxious vocs ii mofs to mitigate nox in real scenarios iii mofs to capture h2s iv predictive modelling to forecast contaminants concentrations evolution coupled with monitoring sensors and conservationmaintenance recommendations v modular designs that fulfil the technical and environmental requirements of controlling iaq vi new business models for the solutions portfolio that integrate the developed pillars supported by market analysis and economic environmental and social sustainability analysis by demonstrating firstofakind energy and resourceefficient solutions for strict iaq management cci will inspire climate transition of 5 new sectors where transferability potential will be assessed and disseminated including through the creation of the simiacci label dedicated exhibitions reaching 30000 visitors will consolidate glams leadership for climate transitionsimiacci brings together world renowned academic materials and conservation scientists deep tech smes bigsized companies and one association to develop 20 prototypes demonstrated in 7 glams of different sizes in different contexts in europe and beyond
the caesar ibd project developing therapeutic antibodies for pets

inflammatory bowel disease ibd in dogs is a common but poorly managed chronic condition causing immense emotional and financial distress to pet owners based on the positive results of antibodies to treat ibd in humans they have been proposed for dogs however instead of investigating a new drug specific for them some antibodies developed for other purposes and species has been adapted petization which can trigger immune responses in pets yielding ineffective therapies and causing further health complications at adivo we have developed and validated caesar platform which is the first fully canine phagedisplay library to generate therapeutic antibodies specific for dogs overcoming the limitations of current petization techniques now we aim to use this technology to develop and validate an effective drug to treat ibd in dogs this project will bring a cumulative profit of 41 m in the first five years of commercialization an roi of 14 and to hire over 15 professionals
portal range monitoring in mixed ion beam surgery

half of the approximately 4 million annual cancer cases in europe receive radiotherapy while many cancer patients have benefitted from technical improvements in recent years widespread diseases such as pancreatic and lung cancer still have dismally low cure rates with median survival of less than 2 years carbon ion radiotherapy cirt offers unprecedented precision in delivering tumour dose and can be the much needed game changer for these patients however cirt is vulnerable to uncertainties in patient positioning anatomy changes and organ motion the current clinical approach is to increase the high dose volume to ensure target coverage counteracting the primary advantage of cirt novel strategies for image guidance and beam range assessment are crucial to unlock the full potential of cirt for the best possible patient carepromise for the first time will produce mixed ion beams that enable concurrent treatment and image guidance carbon ions deliver the dose to the target while helium ions simultaneously accelerated to the same velocity traverse the patient and monitor tumour location and beam range promise realizes true portal imaging providing realtime information on the target anatomy as seen by the treatment beam coupled with innovative detectors aibased image recognition and online dose reconstruction this technique will enable to drastically reduce safety margins and achieve the full potential of cirtthe gsi accelerators are uniquely suited to develop the first mixed beam of carbon and helium along with strategies for their costeffective translation to existing and future clinical cirt centres the method will be validated experimentally in gsis former cirt treatment room patient simulation studies will highlight clinical benefit and characterize ideal use cases a demonstration in an animal model will pave the way for clinical transition the mixed beam image guidance of promise will lead to a paradigm shift in cirt
ict standardisation observatory and support facility in europe

standicteu 2026 builds on the success of the previous two editions 202023 201819 standicteu initiatives delivered by the original partners who prepared the first proposal back in 2017 obtaining the recognition of the goto project on ict standards in europe standicteu 2026s principal goal is to strengthen its global reach in the european ict standardisation ecosystem by a launching managing a robust and efficient facility supporting the fellowship programme with 2925000 funding earmarked over 36 months with 9 open calls b euos eu observatory for ict standardisation and technical working groups twgs empowering contributions from ict standardisation experts c training the next generation of ict standardisation experts engaging with national standardisation bodies ppps through the standards education group euosseg d ensuring hilevel steering of standicteu 2026 by means of an authoritative expert group the eag who tap directly into the wgs tcs of sdos tackling eu priorities challenges gaps e creating an engaging influential forum on eu strategy for ict standards to identify early warnings around sensitive issues in ict standardisation foresttrustit srl it coordinates the effort with 5 highly experienced partners dublin city university ie open forum europe be australo es digital sme alliance be and fraunhofer institute for systems and innovation research isi de principal outputs fellowship programme with open calls 1000 proposals received over 400 funded experts 50 external evaluators 4000 significant ict standards uploaded in the observatory 18 webinars 5 workshops training lectures 2 impact events impact reports policy recommendations 10twgs 25 signed mous 1000 participants in trainings sustainability strategy and a truly engaged well represented multistakeholder ict standardisation community
continuous submk refrigeration by demagnetization of atomic nuclei

the proposed erc poc project is to construct the first continuous nuclear demagnetization refrigerator cndr reaching temperatures near 10 mk has become relatively easy in the last decade this cryogenic advance has driven an explosion in industrial efforts to build quantum computers based on superconducting qubits as well as rapid progress in fundamental physics experiments around 10 mk however cooling condensed matter below 1 mk remains challenging furthermore there is no continuous cooling technology at this temperature the cndr will solve this problem by maintaining the sample temperature below 1 mk indefinitely while providing a large experimental space and eliminating the need for a liquid helium supply we expect the cndr to allow rapid investigation of qubits whose coherence is enhanced at temperatures 10 mk and to propel work in fields ranging from nanomechanics to topological superconductivity