Dragon09/odtu_chatbot huggingface dataset:
geo and weather multirisk impact based early warning and response systems supporting rapid deployment of first responders in eu and beyond

gobeyond is an innovation action that will develop and test multirisk impactbased early warning system mriews platforms for geohazards and weatherclimate events adapted to support civil protection authorities and first responders in their situational awareness and rapid deployment in europe countries of the union for mediterranean ufm and beyond for this end gobeyond will capitalise on the legacy of ews for highimpact geo and weatherclimate events and on the impactforecasting algorithms from previous projects of the consortium gobeyond will identify most innovative algorithms for geohazards and incorporate them with available weatherclimate impactbased algorithms into a common iews these algorithms will be integrated with highresolution vulnerability exposure and risk information at regional and local levels to describe the severity of the hazards in terms of the expected socioeconomic impacts to evolve towards a realtime dsss mriews will be codesigned in a participatory framework in which authorities citizens and civil society representatives can feel listened to and actively engaged in codesign and cocreation roles gobeyond will test the mriews platforms developed for international europe and ufm countries regional and municipal environments this will be done through the 5 regional demonstrations in andalusia es attica el campania it a canton in switzerland and the al hoceima province morocco a sixth demonstration in 4 eu municipalities will test advanced capabilities as communication services based on the latest developments on site specific warnings crowdsourcing techniques artificial intelligence sms cell broadcast and capacities to trigger actions from regional emergency and selfprotection plans the platforms will run in 6 realtime 247 operational demonstrations during 24 months of the project to test them in realtime under conditions of operational use achieving trl 7 and 8
hydrogen from renewable energy for commercial building heating a full supply chain demonstration

the overall aim of the h2heat project is to demonstrate the full value chain for green hydrogen h2 heating for commercial building heating 40 of total energy consumed and 36 of greenhouse gas emissions in eu correspond to buildings with 79 of that energy used for heating of water and air conditioning h2heat in exciting alliance with the canary health service scs wish to create a full demonstration of green h2 for heating and later energy this will serve as the replicable model to be rolled out across the scs hospitals enabling the scs fulfil its ambitious health zer0 net emissions strategy delivering deep decarbonizationh2heat will use offshore wind renewable energy re to produce h2 from esteyco 6mw eu funded wheel project the centralised onshore h2 facility will produce h2 initially with a 1mw electrolyser to be used to substitute conventional fuel by the large enduser hospital chuimi with substantial heating requirements 05mw using a novel combination of an advanced combustion technology burner specifically designed for h2 operation h2chp and a heat pump the h2chp will produce heat and energy and the energy will power the heat pump for substantial heat provision to the hospital with no waste full endtoend infrastructure for h2 transport and use will be planned installed and commissioned comprehensive and complementary mixture of expertise and knowhow provided by the consortium partners will ensure an efficient realization of the technical objectives of the project reduce total cost of ownership tco of h2 fuel for consumers and develop replicable business models for widescale commercial usage of h2 as a direct heating alternative across gran canaria h2heat will contribute to enabling gran canaria become part of the h2 valley economy through locally produced h2 from re
blood flow induced thrombosis and stenosis due to cannulation an interdisciplinary study

in extracorporeal organ support ecos one or more organ functions fail and are replaced by an artificial device kidney failure requires hemodialysis at least until transplantation temporary lung andor heartfailure may be treated by extracorporeal membrane oxygenation ecmo about 15 million patients require hemodialysis worldwide ecmo has an essential lifesaving role during the ongoing covid19 pandemic as during the influenzae h1n1 pandemic in 2009 in ecos two or more accesses are used one for blood drainage and another to return oxygenated blood the flow rate in the cannula and the cannulated blood vessels is often significantly higher than physiologically experienced the high flow velocity implies larger forces stress acting on the blood cells and the vessel walls thromboembolism and morphological and mechanical changes in the affected blood vessel are common complications in ecos this project focus on the impact of blood flow on these complications patientspecific data ct mri and ultrasound based will be used to construct laboratory and simulation relevant frameworks setups for measurement of flow and mixing invitro will be used simulations will include modeling of transport of chemical species and blood cells along with modeling of platelet activation and risk for thrombus formation the different tools will enable a considerably better understanding of the underlying pathological processes the results will support further model development of these processes and facilitate improved cannulation techniques and new devices these propositions are to be assessed by our clinical partners therefore the project group includes fluid mechanical expertise and also clinical specialist in nephrology intensive careecmo and radiology the outcome of research will enable device development and clinical decisionmaking reducing overall treatment complications
testing solid earth climate connections through mid ocean ridge time series

a central problem of understanding the earth system is quantifying climatesolid earth feedback that requires timeseries studies one important time series is the climate sea level record that shows transitions between ice ages and warm periods for the last millions of years involving vast mass transfer between continents ice load and oceans volcanism is sensitive to such pressure changes but its response to glacial cycles is largely unknown for the global midoceanridge mor system where 80 of earths volcanism occurs models of mor response to sealevel fluctuations predict changes in crustal thickness chemistry of lavas and hydrothermal activity establishing highresolution time series on mors however has previously not been possible because the sea floor is rapidly covered by sediment as it moves away from the mor and thus cannot be directly sampled recent studies however show mor eruptions deposit samples of lava as glass on nearby sediments for up to 100 ka these carbonaterich sediments can be precisely dated by oxygen isotope stratigraphy and provide an archive of ridge eruptions glasses and hydrothermal activity trace metals in the sediments that can be sampled by gravity coring through closely spaced new cores to be retrieved during multiple research cruises a highresolution time series of volcanism and hydrothermal activity can be achieved and directly linked to the climate record whereas seismic techniques can be used to determine variations in crustal thickness over time we propose to obtain integrated data sets for all these processes from slow intermediate and fast spreading ridge segments over the past 15 ma in unprecedented detail the results of these glass sediment and crustal thickness time series will allow us to unequivocally test the influence of glacial cycles on mor processes and will provide the first highresolution time series of ocean ridge magmatism opening up a new frontier of scientific exploration
connecting mitochondrial defects to reduced autophagy in metabolic liver diseases through fatp2

hepatic mitochondrial dysfunction is a common clinical feature of several metabolic disorders including type 2 diabetes t2d and nonalcoholic steatohepatitis nash mitofusin 2 mfn2 a transmembrane protein necessary for mitochondriaendoplasmic reticulum tethering is decreased in t2d and nash moreover its liverspecific ablation promotes the manifestation of nash and increases the susceptibility to developing liver cancer in mice recently the zorzano lab has identified several interactors of mfn2 involved in lipid transport the mitotua project focuses on the study of fatp2 a fatty acid transporteracylcoa synthetase predicted to participate in mitochondriaassociated autophagosome formation during starvation we plan to perform a battery of in vitro and in vivo experiments to properly characterize the mechanistic implications of mfn2fatp2 interaction to autophagy activation and mitochondrial function the mitotua project will also investigate the relevance of fatp2 to the hepatic alterations connected to the metabolic syndrome by using murine models of liver steatosis obob and dbdb mice and nash cdahfd diet and analyzing liver biopsies of patients with fatty liver disease the combination of my strong background in complex metabolic syndromes and the wellrecognized expertise of the zorzano lab in the study of autophagy and mitochondrial metabolism will undoubtedly result in a wellconducted scientific project and a successful reciprocal transfer of knowledge overall this fellowship represents a unique opportunity to enroll in a prolific research group of a distinguished institution taking advantage of an ecosystem shaped to maximize the potential of this proposal and acquire new competencies that complement my scientific preparation reaching the professional maturity necessary to become an independent researcher in the forthcoming years
a unifying principle underlying social bonding towards a psychobiological theory

imagine a first date where partners feel an immediate bond versus an awkward date where partners feel disconnected biobond asks whether there is a biological mechanism that is set to differentially favour bonding in the first date over the second despite substantial research on social bonding we are still without an understanding of what drives social animals to bond and prefer selected individuals biobond aims to provide for the first time a novel and empiricallyvalidated biological theory of sociality tying fundamental physiological processes like glucose metabolism arousal or temperature to social bonding where physiological efficiency during interactions impacts bonding probability this is not limited to romantic partners but rather is suggested as a unifying principle that explains bonding any social interaction that advances physiological gains reinforces bonding empirically validating such a unifying principle would demonstrate how complex behaviour emerges from a simple biological feature importantly since physiological gains are quantitative they can implement selective bonding where interactions with higher physiological gains are more strongly reinforced my approach is interdisciplinary lying at the intersection of neuroscience biology and psychology with four mutuallyinformative lines of research 1 demonstrate how social interactions impact physiology by quantifying glucose metabolism arousal and temperature during interactions v alone in two major human bonds parental and romantic 2 map the neurobiological pathway via which interactions impact physiology in realtime social interactions 3 demonstrate a causal effect of physiological gains on bonding by altering physiology during interactions 4 provide an evolutionary perspective by demonstrating it in an additional social species biobond is ground breaking in offering a novel theorybased testable biological mechanism for bonding across bonds and species
reusable battery module and management system development for reliable 2nd life

reborn project aims to promote the utility of second life battery packs by engaging sophisticated safe and costefficient software and hardware architectures towards achieving this goal the consortium tends to enhance the assembly and disassembly process by providing solderless mechanical interconnections and wireless rf communications among the cells and the bms also a cybersecured and optimal data transfer is achieved with cloud based storage the data analytics are performed based on novel physicsbased and ai algorithms in order to obtain ageing performance unique cell indicators with respect to a battery passport conceptreborn aims to minimize the postcharacterization process on the battery packs received from 1st life and achieve faster screening and sorting based on smart strategies that combine the cell data identifiers from the cloud and ml sorting algorithms the project will target to mobility and stationary applications and it will provide an agnostic and technology neutral regardless of cell chemistry or form factor modular design methodology an enduser demonstrator will be built and evaluated in the relevant environment accounting for reconfigurable battery packsthe consortium will deploy semiautomated robotic dismantling strategy based on virtual reality control of the battery packs that will enable a safer and rapid process a prospective lca method will be carried out to understand and quantify the benefitsimpacts of using 2nd life battery with the proposed methodology ease of use and adaptivity costeffectiveness and accelerated processes along with optimal performance and ecofriendliness are among the major objectives of reborn project to uptake the second usage market
european parntership driving urban transitions

the dut partnership builds upon and steps up the ambition and efforts of the joint programming initiative urban europe jpi ue with its partners from 28 countries it dut aims at developing and implementing a transformative research and innovation ri programme to strengthen urban transitions towards climateneutral inclusive and sustainable urban areas with national and regional ri programme owners funders and urban policyrelated public authorities dut is strongly building upon and aligning with national and regional strategies and policies in order to support cities along their specific strategies the partnership focuses on three critical urban sectors energy mobility and circular economy and their interrelations three transition pathways tps positive energy districts ped the 15minute city 15minc and circular urban economies cue will be addressed with a longterm perspective dut will not only provide funding for transnational ri projects in and across these areas through implementing cofunded jcs but establish a comprehensive programme management to support capacity building and enhance the policy impact of these projects and their results in this regard programme activities will address capacity building and empowerment of all urban stakeholder groups to engage in urban ri and codesign solutions urban living labs ulls will be fostered as an important concept to support local experimentation and inter and transdisciplinary collaboration new approaches towards dissemination and mainstreaming of research results will be developed with the ambition to bring results into our cities strategic synthesis as well as recommendations and references for policy making will be provided with particular focus on contributions to the urban agenda for the eu uaeu the european mission for climateneutral and smart cities cnsc and the european green deal egd efforts will be taken to position the dut partnership internationally and mobilise international partners to join forces in dutthis grant agreement ga covers activities implemented during the first seven years 20222028 of the dut partnership planned duration of 12 years 20222033 the commitments included in this ga are dedicated to the first 2 calls and are based on the indicative commitments given by countries for the entire dut duration 20222033 in the early preparatory phase
empire of solidarities a connected history of private charity across a decentred romanov empire 18551914

by the late nineteenth century the romanov empire stretched halfway across the globe turning inhabitants of the territory stretching from todays tallinn to vladivostok into subjects of one and the same empire yet we know little about whether the population felt any impulse to help one another in times of need under what circumstances did people feel compassion towards distant others and how farranging did their sympathies extend what did these solidarities mean how were they enacted and expressed through ideas emotions and lived experiences if solidarities could reach across such a multiconfessionally and multiethnically heterogenous empire how does the romanov experience enrich our understanding of empire and solidarity as seemingly irreconcilable notions empsolid applies an unconventional lens to answer these questions it pioneers a new history of affective practices that for the first time focuses on private charity as a method to make solidarities visible and allow us to study them in action the projects objectives are to 1 trace the conceptual history of solidarity in the empire 2 gather and analyse examples of grassroots private charitable initiatives benevolent and charitable associations fundraising campaigns and private donations across four regionally distinct romanov imperial border regions baltic provinces southwestern provinces south caucasus turkestan from 18551914 on behalf of beneficiaries outside of the givers vicinities and 3 digitally map flows and networks of donations to generate insights into larger trends and spatial patterns in charitable practices the projects ambitious decentring perspective aspires to envision a longoverdue new spatial history of the romanov empire in the long nineteenth century founded on horizontal threads of solidarity linking regions and postulates that these charitable entanglements formed a crucial part of the social fabric holding together nineteenthcentury empires
more effectively using registries to support patientcentered regulatory and hta decisionmaking

while randomized controlled trials rcts remain the mainstay in drug development approval and reimbursement the potential of real world data rwd to contribute to the understanding of drug effects is increasingly realized evidence based on rwd real world evidence rwe can contribute significantly to the evidence to support decision making throughout all phases of clinical drug development as well as improve efficiency in design and conduct of clinical trial programs the aim of this project is to develop implement and establish evidentiary standards and methods to address the data and evidentiary needs of regulatory authorities and hta bodies towards a more efficient use of rwd for the development registration and assessment of medicinal products in europe moreeuropa
magnetoionic datasecurity device integrated on flexible substrates

traditional methods of safeguarding data often fall short in todays rapidly evolving information technology landscape passwords are vulnerable to hacking and while encryption offers enhanced security it significantly increases data processing costs and slows performance storing secret keys in batterybacked memory is also inefficient in terms of energy consumption the advent of physical unclonable functions pufs which create unique device fingerprints based on random physical properties marked a significant leap in hardwarelevel data security despite recent progress in puf technology challenges such as energy efficiency cost scalability randomness and reconfigurability remain overcoming these hurdles requires innovative materials and designs securefleximag aims to strengthen data security and promote technology transfer by building on the pis recent research in three key areas i magnetoionics ii exchange coupling to lock access to data and iii stochastic magnetization reversal phenomena in arrays of magnetic dots these effects can be synergistically combined to develop an advanced datasecurity device that will largely surpass conventional password methods and current puf approaches the project will explore market prospects and business development strategies in collaboration with various stakeholders and potential end users
novel diffuse optical method to combat skin color bias in noninvasive optical biomarker sensing devices such as pulse oximeters

during covid19 skin color bias in optical biomarkers sensing obs devices eg pulse oximeter was suspected to have contributed to the loss of lives in darkly pigmented people the continuous wave cw technology used in these devices is limited in accuracy and results are biased by skin color and light scattering in tissuenobias aims to break through frontiers to create foundational multilayer fast time domain diffuse optical spectroscopy tddos to eliminate color bias and inaccuracy shortcomings of current cw technology and revolutionize the future of biasfree accurate optical biomarker sensing to achieve this ambition nobias will create a multilayer tddos dynamic skin tissue model based on monte carlo to investigate the effect of skin type and anatomy on color bias to optimize the concept device and probe design to compensate and eliminate color bias and inaccuracies wp1 obj1 2 groundbreaking approaches i intermediate hybrid cwtddos fusion approach phase 1 is envisioned to compensate for skin color bias followed by ii an ambitious new frontier fast tddos approach phase 2 to eliminate color bias wp2 obj2 and provide faster 100250x real time measurements at wearable footprint 100x a firstofakind compensation algorithm based on realtime instrument response function irf and phantom arm aims to deliver groundbreaking accuracy 14x wp3 obj3 early benchtop testing and feedback across work packages will mitigate risks of ambitious objectives nobias paradigm devicealgorithm will be validated on tissuemimicking phantoms and biasfree sensing will be demonstrated on blood biomarkers haemoglobin hb hbo oxygen saturation sto2 spo2 sensing at wrist location on healthy i adults ii infants wp4 obj4 nobias breakthrough lays the foundation for the worlds first biasfree and accurate obs devices and sets its legacy to be the gold standard for biasfree clinical and personal biomarkers sensing applications
fair earth sciences environment services

earth and environmental sciences require a large panel and volume of data from satellite insitu observations models omics experiments earth system domains are interconnected and even if interfaces between domains appear of primary importance for several studies with large societal impacts such as climate change agriculture and food human safety and health the present digital architecture is based essentially on distributed and domaindependent data repositories inducing real difficulties for integrated uses of all the environmental datato go beyond this stateoftheart the overall objective of fairease is to customize and operate distributed and integrated services for observation and modelling of the earth system environment and biodiversity by improving the trl of their different components implemented in close cooperation with usercommunities the european open science cloud and research infrastructures in their design and sustainable availability the project will 1 improve a fairease data discovery and data access service relying on preoperational existing services in order to provide users with an easy and fair tool for discovery and access to environmental multidisciplinary and aggregated datasets as managed and provided by a range of european data infrastructures 2 set up a fairease earth analytical lab with eosc connectivity supporting through webbased interfaces predefined processing tools and ondemand data visualization services for remote analysis and processing of heterogeneous data facilitating the crossdisciplinary collaboration reducing the time to results and increasing productivity and 3 develop a number of multidisciplinary use cases ucs to contribute requirements for the fairease system components and to validate and demonstrate the capabilities of the fairease service for supporting open science