Dragon09/odtu_chatbot huggingface dataset:
a novel multifunctional elastinlike recombinant hydrogel for the prevention of scar tissue formation following a myocardial infarction elrscar

the elr scar project aims to complete preclinical validation of a novel biomaterial an elastinlike recombinant elr hydrogel to prevent scar tissue formation in the heart following myocardial infarction mi commonly called a heart attack mi is the endpoint of ischaemic heart disease ihd in europe the highest rates of ihd worldwide equal 265 million patients standards of care interventions after mi have serious limitations in treatment efficacy many patients are still at risk of developing heart failure and patient safety there is a clear medical need for new treatment solutions that prevent scar tissue formation and irreversible cardiac remodelling our robust preclinical dataset so far indicates that the elr hydrogel has this promising functionality via multiple unique characteristics it provides selective cell adhesion to the endocardium providing a barrier to scar tissue formation it offers high biospecificity to the ischaemic microenvironment and it has an enhanced biodegradability allowing for safe disintegration in the body to facilitate endocardial delivery of the elr hydrogel we will develop a minimally invasive endocardial catheter in this project both components hydrogel catheter will be advanced to the preparedness level for a firstinhuman fih validation study for the application as therapeutic intervention postmi to be performed after the project in addition we will develop the regulatory and ipr strategies in preparation for this clinical validation step considering the high societal impact of ischaemic heart disease ihd and mi we will also develop a solid health economic evaluation of possible savings and patient benefits elrscar will transform and fundamentally improve clinical practice resulting in reducing the enormous burden that mi and its leading cause ihd place on society and the individual patient
deepbody wireless bioelectronics enabled by physicsbased bioadaptive wave control

wireless medical devices can be implanted in the body to monitor health and to deliver therapies recent advances in biosensors neural interfaces biotechnology microelectronics and improved surgical techniques enable a vision of minimally invasive batteryfree bioelectronic implants that can perform a wide range of medical and research tasks examples include biosensing for an early detection of health anomalies recording and precision stimulation of central and peripheral nervous systems implantable labsonachip surgical microbots and so on a key scientific challenge lies in how these devices can be powered and controlled from outside of the body existing wireless solutions remain limited in their ability to transfer energy and data these limitations result from the difficulty in controlling electromagnetic waves in the human body a dynamic heterogeneous and lossy medium the objective of this proposal is to develop bioadaptive wave control technologies that overcome these challenges to enable efficient powering and precise control of mmmscale deepbody bioelectronics to accomplish this we will 1 focus on the fundamental studies of waves and their control in complex and dynamic anatomical media 2 develop new reconfigurable architectures of conformal radiating surfaces for the practical implementation of the developed wave control methodologies and 3 demonstrate clinical utility by fully wireless recording and modulation of the pancreatic nerve activity in an anesthetized porcine model through dynamic wave control the proposal relies on interdisciplinary trackrecord of the pi in bioelectronics and neural interfaces wave physics and computational electromagnetics conformal radiating structures and wireless power transfer bessel consolidates these skills and enables conducting research on highly capable deepbody wireless bioelectronics with high translational potential
support to reinforce the european strategy forum on research infrastructures 3

the key objective of stresfri3 is to provide highquality and flexible support to esfri in achieving its goals based on the white paper 2020 strategy increasing its visibility operational and analytical capacity along with its impact on developing a consistent and dynamic european research area era policy for research infrastructuresthe project builds on the experience of the previous esfri support projects having successfully supported esfri in the realisation of a series of esfri roadmaps 2016 2018 2021 and corresponding landscape analyses of the esfri white paper 2020 making science happen and of a series of related communication actions and events including workshops for the exchange of experiences eoe among ris and for the interconnection of ris in eosc stresfri3 aims at reviewing and enhancing its current support activities in the areas of the esfri roadmap process and the landscape analysis the ri monitoring and the mos platform and in the area of eosc liaising with the eosc association with emphasis on researcher engagement and ri federation in eosc furthermore stresfri3 aims at expanding its activities to new areas in particular to support esfri in its european research area erarelated activities including the upcoming era policy agenda where ris is one of its key actions this is also linked with the development of a sustainable support structure esfri office for which an analysis of possible scenarios for related support structures including the creation of a legal entity will be performed with the support of external contractorsthe project will support esfri during a 4 year period 20222025 the consortium builds on the experience and expertise of the partners in previous stresfri projects athena hipc and umil incorporating the support institutes of the elected chairs for 20222023 ul and 20242025 csic for the latter dedicated budget was planned under the coordinators budget transferred to csic as part of the amendment
european platform for accessing nuclear rd facilities

the overarching objective of offer is to support the snetp association to establish an operational scheme facilitating access for rd experts to key nuclear science infrastructures hereinafter referred to as user facilities through the channelling of financial grants provided by the euratom programme the beneficiaries of the scheme will be first the user facilities to be funded directly from the offerr project for their services provided to selected projects selected through offerr calls and second the research teams that have successfully applied through the calls and were allowed to use the user facilities for their project purposes
research analysis identifier system

the mission of raise is to provide the infrastructure for a distributed crowdsourced data processing system moving from open data to open access data for processing raise will provide the mechanism for sending the algorithm to the dataset instead of sending the data to the algorithm the real value of open data for the research community is not to access them but to process them as conveniently as possible in order to reduce timetoresult and increase productivity raise aims at promoting a transparent way of sharing and processing data enabling the research community to publish their work with evidencebased authenticity of the dataanalysis performed ensuring at the same time the accreditation of their work raise will be grounded on the fundamental principle defined in the fair guiding principles for scientific data management and stewardship findability accessibility interoperability and reusability to do so raise brings the processing algorithm small size to the dataset large size instead of downloading the dataset to the computer where the processing algorithm is to increase the processing capacity of the dataset repositories raise borrows the crowdsourcing concept where researchers can easily integrate in the existing workflows computers serving both their datasets and the processing capacityraise will produce the following outputs1a trustworthy crowdsourced network of rai certified nodes offering data storing and processing resources 2the rai cloud platform to orchestrate the data sharing processing and finding3the research analysis identifier rai a unique identifier of any result along with the dataset information and the processing script without disclosing any source code or raw data4dataset plagiarism identification and dataset proofoforigin services to maximise the level of trust of the raise system5the rai synthetic data generator
models with cross interactions between partial dynamical processes aiming to understand significant or abrupt dynamic changes

bifurcation analysis of nonlinear models is a powerful tool that has a practical use since it detects and explains dynamical changes it allows a description of generally emerging phenomena dependent on parameters this project aims to understand significant or abrupt changes in dynamics of models related to crossinteractions between partial dynamical processes and study how these crossinteractions affect the systems behavior as a whole the project covers three fields of applied nonlinear dynamics population biology neuroscience and epidemiology uncovering the dynamics of coupled preypredator models population biology which includes persistence and extinction of the populations in crossinteracting patches the emergence of periodic and aperiodic attractors emergence of chaos comparison of dynamics of the coupled model and the uncoupled one uncovering the dynamics of coupled neuronal subsystems with respect to possibleimpossible abrupt dynamical changes and synchronized dynamics uncovering dynamics of coupled epidemic subsystems with emphasis on dynamics of covid19 epidemics to understand connections between dynamics of local and global outbreaks interacting of subpopulations of various mutations and even seasonal effects i expect following exploitation of the results theoretical in mathematical biology new knowledge in population biology neuroscience and epidemiology applied new knowledge of suitableunsuitable models with respect to bifurcations qualitative dynamical changes and emerging nonlinear phenomena in real world systems educational models attract attention of students and facilitates study of difficult passages of abstract mathematics and practical in applied mathematics part of the project is to strengthen the team of prof pibylov mu including connection with the research group of prof meijer ut in the field of applications in models of neuronal synchronization towards their focal epilepsy research
implantable microrobot

smallscale medical robotics was born from a science fiction vision shrinking down a group of surgeons and letting them swim to the brain to save a patients life this vision calls for precision efficiency in delivering force and noninvasiveness conversely the microrobots proposed so far are only able to perform drug or cell delivery furthermore their capability to keep an active configuration is strictly dependent on the presence of a certain external stimulus in this erc project i aim to tackle these challenges by devising new actuation mechanisms control and imaging strategies allowing the microrobots to exert suitable forces and prolonging their lifetime ibot proposes the first generation of implantable microrobots featured by a multimaterial structure including a liquid perfluorocarbon core and a shape memory polymers magnetic composite skin by exploiting magnetic material programming microrobots will be capable of multimodal locomotion under magnetic guidance upon target reaching low intensity pulsed ultrasound and alternated magnetic fields will trigger acoustic droplet vaporization and magnetic hyperthermia this will produce simultaneous volumetric expansion of the internal chamber and deformation of the surrounding skin to allow fitting the implant site shape memory polymers will ensure shape locking upon removal of the triggering signals thus stable implant ultrasound acoustic phase analysis will allow microrobot tracking over the entire implant procedure and prolonged lesion monitoring upon implantationthe ibot approach will be validated in three relevant validation scenarios ulcer filling vascular graft and long term tumoral lesion monitoring to demonstrate the flexibility of the approach and to unveil the potentialities and the impact of implantable microrobots as a final step the most promising validation scenario will be tested in vivo in large animals as a step forward in moving microrobots from the bench to the bedside
naturebased solutions for demonstrating climateresilient critical infrastructure

as climate disruptions become more frequent and intense the resilience of europes infrastructure is crucial as it supports economic flows human wellbeing and social stability throughout the continent however this challenge provides a historic opportunity to revolutionise infrastructure by integrating it with nature hence naturedemo creates validates and spreads naturebased solutions nbs for protecting infrastructure against climate threats it covers critical sectors eg transport and energy and engages an alliance of infrastructure owners scientists from industry and academia and public authorities naturedemo aims to shift decision management from reactive measures to proactively designing holistic systems that are resilient by design through four actions create validate scale and sustain naturedemo will create an advanced digital decision support platform that will integrate climate projections asset exposure nbs catalogue portfolios and advanced simulations to optimise the efficiency of selected nbs implementations to enhance resilience and deliver cobenefits naturedemo will validate its methodology with realworld demonstrations of optimised nbs across 5 sites in the alpine biogeographic region successful nbs will then be scaled as replicators in 4 other sites in the alpine and other biogeographic regions naturedemo will sustain its solutions beyond its timeframe by focusing on exploitation pathways that include tailored guidelines that disseminate nbs knowledge across infrastructure professions a taskforce available to provide technical expertise and a financial observatory for nbs fundsby pioneering a scalable digitallyenabled and validated framework for implementing nbs naturedemo will help realise the eus vision for a climateresilient and sustainable economy optimised for the realities and demands of the 21st century a vision for posterity
training for a hydrogen economy based renewable energy society in the anthropocene

thanks to the long standing collaborations among the universities of rovira i virgili spain groningen the netherlands and eastern finland finland theresa proposes the first european doctoral programme for legal specialists in the field of the hydrogen economy in the context of climate emergency and socioecological transition of the anthropocene green hydrogen is a promising energy carrier to facilitate the transition to an energy system based on renewable energies hydrogen can replace natural gas as a feedstock and help fossilbased economic sectors for which electrification is not possible or excessively burdensome to lower their greenhouse gas emissions yet the development of a hydrogen market is characterized by uncertainties and associated economic societal and environmental risks the few existing scholarly legal studies on this subject matter highlights the fragmentation of the regulatory framework applying to hydrogen theresa combines the focus on three specific themes of regulatory intervention in the hydrogen economy 1 reducing sectoral fragmentation to spur socioenvironmental sustainability 2 enabling sustainable circular use of hydrogen and 3 societal engagement in the hydrogen economy with three methodological approaches doctrinal constructivism empirical legal research and legal comparativism to advance scientific knowledge and form the doctoral experts needed to contribute to the development of a hydrogen economy theresa encompasses a fullyfledged training programme offering substantive theoretical methodological and transferable skills to the early state researchers theresa addresses the gender dimension and other diversity aspects not only in the esrs selection but also in its theoretical framework
centaur copernicus enhanced tools for anticipative response to climate change in the emergency and security domain

within horizoncl42021space0143 copernicus security and emergency services evolution the objective of centaur is to respond to societal challenges deriving from climate change threats by developing and demonstrating new service components for the copernicus emergency management service cems and copernicus service in support to eu external action service sea aiming to1 improve situational awareness and preparedness around climate change and its impact on complex emergencies and multidimensional security crises2 anticipate the occurrence and possible knockon effects of crisis events in particular those triggered by climatic extremes thus contributing to resilience and effective adaptationin the emergency domain centaur will address the floodrelated threats to population assets and infrastructures in urban areas in the security domain centaur will address water food insecurity the two work streams will be connected via a crosscutting component focusing on exposure and vulnerability to climate change as well as resilience and societal capacity for managing environmental risks and social conflict across work streams indicators and models will be validated by different methods centaur will integrate data coming from multiple heterogeneous sources with a specific focus on those generated by other copernicus services and in particular those of the climate change service it will combine these with meteorological data socioeconomic data and data coming from new sensors eg traditional and social media thus it will enhance current capacities to produce composite risk indexes and to perform multicriteria analyses in the emergency and security domains
hamiltonian dynamics normal forms and water waves

kam and normal form methods are very powerful tools for analyzing the dynamics of nearly integrable finite dimensional hamiltonian systems in the last decades the extension of these methods to infinite dimensional systems like hamiltonian pdes partial differential equations has attracted the interest of many outstanding mathematicians like bourgain craig kuksin wayne and many others these techniques provide some tools for describing the phase space of nearly integrable pdes more precisely they give a way to construct special global solutions like periodic and quasiperiodic solutions and to analyze stability issues close to equilibria or close to special solutions like solitons in the last seven years i developed new methods for proving the existence of quasiperiodic solutions of quasilinear onedimensional pdes this is an important step towards treating many of the fundamental equations from physics since most of these equations are quasilinear in particular this is the case for the equations in fluid dynamics the water waves equation being a prominent example these novel techniques are based on a combination of pseudodifferential and paradifferential calculus with the classical perturbative techniques and they allowed to make significant advances of the kam and normal form theory for onedimensional pdes on the other hand many challenging problems remain open and the purpose of this proposal is to investigate some of them the main goal of this project is to develop kam and normal form methods for pdes in higher space dimension with a particular focus on equations arising from fluid dynamics like euler navierstokes and water waves equations by extending the novel approach developed for pdes in one space dimension i have already obtained some preliminary results on pdes in higher space dimension like the euler equation in 3d which makes me confident that the proposed project is feasible
renewing the world a philosophical history of early modern ecology

this project undertakes the first comprehensive investigation of early modern ecology newworld counters the standard historiographical argument that ecological concern is a recent phenomenon a key element in that claim is the assumption that the terminology of environmental care is recent the term ecology was invented in the 19th century by ernst haeckel sustainability is a 20thcentury coinage the environment was used for the first time in english by thomas carlyle in 1827 yet these terms that now help to define ecological sensibilities arose from longlasting debates the leading claim of this project is that early modernity was a particularly fertile period for ecological reflection newworld proposes an innovative methodology to capture the breadth and philosophical substance of early modern ecological debates it proceeds from presentday terms to construct terminological and conceptual constellations in early modern texts it uses a technique that historians of philosophy label controlled anachronism and which this project aims to fully exploit for the first time on a large scale the objectives subdivided into the four main areas environment pollution sustainability and ecological justice involve tracing a symbiotic connection between metaphysical naturalphilosophical religious and ethical ideas newworld will both reveal the specificities of early modern thought on ecological matters and pioneer a dialogue with ecological debates as we know them today the projects main output will be a multivolume philosophical history of environmental care in the early modern period this will be complemented by the curation of an exhibition featuring 3d models of cosmographical images and projections of early modern plans for ideal cities showing them to be laboratories of ecological views newworld seeks to offer a new paradigm for the intervention of the history of philosophy in presentday debates on ecology and beyond
ultralight selfcorrecting live mirrors lowering the areal density of mirrors and maximizing performance with nonabrasive additive 3dprinted novel technology

we propose to develop ultralight selfcorrecting mirrors for use in the next generation of large optical telescopes and solar energy concentrators presently the best mirrors have a density of about onehalf a metricton per squaremeter or more in order to provide the stiffness which is necessary to keep the optical shape under the variable conditions given by the changing gravity vector as the telescopes track a position on the sky as well as to withstand variable wind conditions we intend to replace such a massive mirror with a sandwich of very light optically perfect fireglass window pane coated sheets stiffened with layers of electroactive polymers that can be deposited through additive manufacturing 3d printers the sheets of glass will be heated to 800o c in a pressurized tailored made kiln and allowed to relax their backside onto a suitable mould cast to a predetermined offaxis aspheric parabolic shape while keeping the temperature below the devitrification temperature of the glass thus preserving the excellent optical surface quality of fireglass window pane using the addressable energy of the electroactive polymers will provide not only dynamically selfcontrolled stiffness but also variable pushpull action realtime multisensing controlled and calibrated in order to keep the optical surface to a liveperfect shape under general operating conditions these livemirrors shall provide optical surfaces of as high a quality as those of the current best telescopes but with larger dynamic range and a reduction in weight and cost of more than one order of magnitude such mirrors will allow the development of 50100 meterclass telescopes as well as of the next generation of space telescopes on the ground they will also offer very low cost options for the next generation of solar energy concentrators and for antennas used for optical communications