Dragon09/odtu_chatbot huggingface dataset:
zero emission electric vehicles enabled by harmonised circularity

zevras main objective is to improve the circularity of lightduty evs throughout their entire value chain from materials supply and manufacturing to endoflife eol processes which aligns with the european unions goal of achieving zero co2e emissions by 2035 particularly in the ev value chain to do so zevra will develop a design for circularity dfc methodology and a holistic circularity assessment aimed at improving the production of electric vehicles evs based on the 9rs this methodology will be validated by developing zero emission solutions for the most important automotive materials covering 84 material mix steel three versions of aluminium wrought casting and foam thermoplastics composites long and continuous fibrereinforced unfiledshort fibre plastics glass tyres and rare earth elements ree these solutions will be supported by a set of digital tools to support the manufacturing of the use cases the assessment of circularity traceability and the virtual integration of components into a full replicable vehicle to maximise the outreach of our methodology and zero emission solutions zevra will develop a dedicated training upskilling programme for the automotive workforce and academia together with activities aimed at increasing awareness acceptability of the proposed zero emission solutions lastly circular business models targeting eol and logistics aimed at improving the economic feasibility of circularity in evs are advanced zevras innovations aim to improve zero emission approaches in the life cycle and value chain of at least 59 of european evs by 2035 through the 5 oems and tier 1s that are part of the consortium which includes industry and academia covering the entire automotive value chain
welldefined silicasupported titanium catalysts for introducing nitrogen functional groups

amines are commercially valuable compounds used in a wide range of products including pharmaceuticals agrochemicals and polymers global market usd 166 billion but their industrial synthesis is inefficient and expensive alternatively nitrogen functional groups can be synthesised by green 100 atom efficient reactions hydroamination and hydroaminoalkylation that are catalysed by earthabundant homogeneous ti complexes these reactions are not yet industrially viable due to high costs of catalyst recovery and product purification we need to develop catalysts for these processes that exhibit the high activity and selectivity of homogeneous ti catalysts but are industrially viablethis project will develop new heterogeneous catalysts for introducing nitrogen functional groups by immobilising ti complexes based on homogeneous catalysts for hydroamination and hydroaminoalkylation onto silica surfaces it will blend the disciplines of chemical synthesis homogeneous catalysis and surface organometallic chemistry by using the expertise of researchers and specialist facilities in canada and france i will synthesise novel catalysts featuring welldefined ti metal centres supported by ligands immobilised on silica surfaces optimise their activity for hydroamination and hydroaminoalkylation on industrially important substrates and investigate the mechanism of the reactions to optimise and enhance industrial applicabilitythis project will transform green processes to manufacture nitrogencontaining chemicals from academic research into industrial routes knowledge and key skills in chemical synthesis catalyst development and surface organometallic chemistry will be shared between european and canadian researchers resulting in a synergic partnership impacting academic and industrial fields i will apply my previous experience and learn new technical and transferable skills which will advance me to my goal of becoming an independent academic researcher
understanding the role of diversity in european research

the recent intensive sociopolitical debates on racism and the colonialism which created a wave of protests across the global north has broken the ordinariness of the racial status quo endemic to the modern social institutions in academia it has enforced a series of initiatives asking for reconsidering curricula and diversity quotas the urder project takes a step back from these societal debates to understand how practices of diversity are understood and applied by those who have a central impact on academic knowledge production and science more generally the reviewers of academic grants by studying the evaluation practices of the review panelists of the european research commission grant awards the project will explore how scientific excellence is linked with diversity practices in the european research space bringing together a science policy studies b cultural sociology and c postcolonial critique the urder project seeks to investigate how the european academic elites in social sciences and humanities understand the role of decolonial antiracist and diversity initiatives in european research the proposed project will allow for training the fellow in science policy research management and research evaluation while the fellow will offer her valuable knowledge in postcolonial theories feminist epistemology and intersectionality to provide conceptual overlaps between these fields of research will allow for critical assessment of diversity initiatives and propose effective solutions to address diversity in academia
quantitative hypoxia imaging for charged particle radiation treatment guidance an improved strategy for aggressive brain cancers treatment

glioblastoma and skull base chordoma are two of the most aggressive types of brain cancers and have an extremely poor prognosis with most tumours recurring within months of surgical and chemoradiation treatments recurrence is caused by tumour heterogeneity as regions of the tumour with different biological properties respond differently to treatment tumour hypoxia low oxygenation is the leading cause of resistance to radiotherapy in heterogeneous cancers and is linked to poor patient prognosis effectively counteracting tumour hypoxia requires delivering higher doses of radiation selectively to hypoxic tumour regions this is hard to achieve with conventional radiation treatment where a uniform moderate radiation dose is delivered to the entire tumour target and doseescalation strategies are limited by toxicity constraints established to limit damage to important surrounding brain structures standard radiotherapy plans do not incorporate any measure of tumour hypoxia due to limitations in imaging techniques currently used for planning the work proposed in this fellowship aims to improve radiation treatment for heterogeneous cancers by combining quantitative mripet imaging to noninvasively characterise regions of tumour hypoxia and carbon ions radiotherapy to deliver higher doses of radiation to those regions whilst sparing surrounding healthy tissue this strategy will deliver a more effective radiation dose distribution providing an opportunity to improve local tumour control and patients survival outcomes and quality of life
the gut and bias benefits the investigation on urolithin metabotypes producer strains isolation and multiomicbased description of ellagitannin biotransformation

ellagitanninrich herbal remedies are used traditionally because of their antiinflammatory activity this is connected not to ellagitannins themselves but to their metabolites produced by the gut microbiota urolithin a uroa is recognized as the most significant of all ellagitannins metabolites however not everyone is able to have it produced in their gut the uroa production is exclusive to the hosts of urolithin metabotype a uma and b umb and is most probably dependent on the gut microbiota composition and activity preliminary trials showed that uma hosts have a lower risk of cardiovascular disease moreover the transition from uma to other metabotypes is also connected to aging which might suggest losing certain beneficial abilities the identity of microorganisms that differentiate uroa producers were not yet revealed if recognized new probiotics might be designed providing nonuma hosts with the possibility to produce uroa efficiently would grant them an advantage due to reports of a wide range of proven and indicated uroas biological activitiesthe project aims to isolate characterize and preserve bacterial strains able to produce uroa from the fecal samples of uma and umb donors this will be possible due to innovative substrate conversion screening strategies and novel metabolomic and sequencing techniques utilization results will provide missing insights about urolithin metabotypes for further explanatory studies focused on the elucidation of umdependant features moreover bioinformatic tools will be developed to obtain multiomic descriptions of the studied processes combining metabolomic and targeted metagenomic data the project will deliver protocols and data analysis methods that will enable us to run advanced projects in the field of natural products biotransformation research the established pipelines will be suitable also for dysbiosis xenobioticmicrobiome interaction and pre and probiotic design studies
commoditizing data analytics in the cloud

the goal of this project is to commoditize largescale data analytics in the cloud which means a to reduce query processing cost to close to what the available hardware is theoretically capable of and b to prevent vendor lockin by making it easy to move data between different clouds and systems to achieve this we will design and develop an open and costefficient analytical database system for the cloud called codacthe codac system consists of three main components first an intelligent control component that automatically and transparently selects and manages the cheapest hardware instances for the given workload and makes migration to other eg european cloud vendors possible second a highlyefficient and scalable query processing engine that is capable of fully exploiting modern cloud hardware third a data lake storage abstraction based on open data formats that enables cheap storage as well as modularity and interoperability across different data systems the resulting system therefore has the potential for making largescale data analytics both cheaper and easier boosting datadriven instruct and science
the upcycled clinic a global ethnography of material creativity in contemporary medicine

as the world wades through covid19 pandemic debris it becomes harder to ignore that medicine is a distinctly wasteful enterprise hospitals in particular have become nodes of disposability solutions to this problem has to date attracted mostly the attention of medical technology companies promoting circular economies a model still reliant on production and technological innovation the upcycled clinic takes a different direction this ethnographic project focuses on creative practices such as repurposing in the clinic involving making the most of existing materials five subprojects have been carefully selected with illuminating examples around the world including antarctica ghana the netherlands the us and uk a team of ethnographers will conduct fieldwork and interviews with a range of actors many often overlooked such as cleaners and laundry staff and look at open datasets of pandemic improvisations the overarching objective is through comparison to better understand conditions which cultivate and curtail creative material engagement in the clinic this inventive and timely contribution to the social study of medicine will advance the field in at least three directions first by attending more closely to materials it moves hospital ethnographies beyond current focus on the patient encounter second it will offer the first globally orientated study of improvisation in the clinic third it breaks new methodological ground in the social sciences by developing novel ways of reusing and sharing research material in ethnography that adopts sensory methods and rethinks data waste these contributions from the rich case of the clinic will add empirical insights to theories of materiality and help address long standing questions regarding resilience and innovation in the workplace practically the study will articulate conditions under which healthcare can leverage creativity and pay better attention to local solutions to wastefulness and shortage
sustainable welfare rethinking the roles of family market and state

sustainwell addresses the longterm socioeconomic impact of population ageing on european society sustainwell aims will be to identify i opportunities arising from longer and healthy life expectancy and in general from the silver economy ii resilient responses from individuals and households in market and nonmarket outcomes and from other actors in society facing the challenges posed by ageing iii the impact of ageing on inequality both within and between generations knowing that social cohesion is crucial to face the ageing challenge iv gender and lifecycle balanced policies helping the sandwichgeneration to sustain babyboomers entering retirement without decreasing fertility nor investment in education particular attention will be devoted to the role of job design to foster intergenerational complementarities in the labour market to better understand the benefits of living longer sustainwell will take a holistic perspective by a investigating the behavioural reactions in key lifetime decisions along the lifecycle education skills fertility work effort home production savings and retirement and the decision process itself leading to prosocial behaviour and b accounting for the three ways to provide welbeing along the lifecycle market family and welfare state both dimensions will be analyzed by extending the national transfer accounts method using comparable eu datasets to be incorporated as inputs in a dynamic microsimulation comparative model quantifying the future of ageing societies sustainwell will take a new multidisciplinary approach in different basic neuroscience and social sciences economics demographics sociology and political science sustainwells results will be pursued in permanent contact with stakeholders to deliver knowledge and evidencebased policy measures by applying a participatory design and cocreation activities
cycling to care integrating emotional wellbeing for proenvironmental behavior change

in an era marked by the global boiling phenomenon theres an intensifying emotional toll from concurrent crises manifesting in heightened anxieties and depressive feelings they are especially palpable among the youth where the intersection with rising climate anxieties often stymie proactive environmental actions due to a nexus of psychological complexities societal dynamics knowledge disparities and infrastructural impedimentsresponding to this multifaceted predicament the cycling to care c2c project intertwines emotional resilience with ecoconscious actions the project anchors its philosophy on the understanding that emotional health and environmental awareness can be mutually reinforcing central to c2cs approach is the cycling without age cwa initiative a unique program that bridges generational divides by enabling young volunteers to offer trishaw bike rides to older individuals in urban green spaces through a longitudinal study held at the institute of global health isglobal c2c assesses the evolution of mental health states and environmental perceptions among young cwa participants in barcelona drawing from these findings the project then crafts and tests an avantgarde sustainability education module at the polytechnic university of catalunya upc enriching cwa encounters with ad hoc seminars and facilitated safe spaces to foster emotional robustness and sustainability literacy in young participants envisioning them as the torchbearers of a better tomorrow ultimately cycling to care stands out as an inventive confluence of mental health support and environmental stewardship holding promise for scalability and adaptability across various cwa chapters and academic institutions across europe
personalised treatments and pain management for repair of aged bone tissue with quantum molecular resonance

regeneration aims to i build a multidisciplinary research network involving experts of technical and medical disciplines to merge their expertise and exploit possible synergies for the development of reliable and sustainable in vitro cell models of healthy and aged bone tissue treated with or without qmr quantum molecular resonance and ii train a cohort of scientists and technologists in exploiting the model features to increase knowledge on the effects of aging on bone biology and mechanobiology and on bone response to qmr to leverage the use of cell models in clinics and basicindustrial research labs bone aging reduces the quality of life of the elderly and puts social and economic burden on society aging bones fail more easily when challenged mechanically or with toxicants or pollutants and respond differently to drugs than healthy bone to personalize therapies and enable better preventive care for the elderly it is essential to develop reliable and sustainable in vitro models of aged bone tissue alternative to animal tests which often fail to capture humanspecific features regeneration will involve 7 participants from 4 countries italy france greece and switzerland and with 3 academic partners and 4 smes the networking activities planned in regeneration will generate new knowledge about the mechanisms of bone growth regeneration and aging about drug and technologies development for bone pathologies and will study the effect of qmr stimuli in cell proliferation differentiation and trasfection by in vitro and computational models
the global war on civilians 19051945

this may be one of the most ambitious efforts to apply the methods of global history to the study of war and society in several countries around the world we explore the evolution of types of warfare that explicitly targeted the enemys civil population waroncivilians focuses on 1 aerial bombardment and civil defense against it 2 food blockades and home front campaigns to ration food and 3 efforts to demoralize enemy civilians while boosting morale at home this is much more than a comparison of discrete case studies global or transnational history emphasizes the connections between nations here we investigate how the circulation of knowledge and practices culminated by world war ii in systematic attacks on civilians and the creation of home fronts that mobilized civilians the spatial sweep is global going well beyond conventional eurocentric accounts we will connect japans long world war ii in china and asiapacific with that in britain germany france and usaplus the seldomintegrated cases of italy spanish civil war and soviet union the pi is uniquely positioned to direct the project a leading historian of japan he also writes transnational histories based on extensive archival research in britain germany and france and in its temporal sweep waroncivilians breaks new ground by researching transnational developments going back to 1905 when japan demonstrated new forms of mobilizing civilians in defeating russia and the british admiralty began planning a wartime blockade of the german food supply we examine the lessons of world war i smaller wars and developments in the oftneglected interwar decades that led to the assault on cities in world war ii the project analyzes the impact of political regimes bombing blockade and civilian morale became common features in a variety of warring statesfrom democracies to authoritarian regimes on right and left despite important differences
fast and accurate solubility for sustainability

solubility measurement is a standard test that is required for every chemical that is produced or tested however measuring solubility is a timelabourintensive process that requires substantial quantities of chemicals stateoftheart solubility measurements are either fast but inaccurate or slow but accurate and require excess of chemicals fass is based on highefficiency second harmonic scattering that combines the analytical advantages of current solubility measurements fast and accurate while achieving cutting edge performance in sensitivity and reliability fass saves 90 of cost 90 of measurement time 99 of chemicals and 97 of electricity and 80 of compounds compared to the gold standard as an optical light scattering technique fass is nondestructive and combined with analytical advantages and sustainable use of chemicals and compounds provides a disruptive innovation in solubility measurement the consortium is composed of a dedicated startup to bring the instrument to market a research and technology organization to support technology maturation a european research consortium to enable customer development and instrument demonstration and a center for pharmaceutical research to explore valueadded applications of fass in drug discovery and development the goals of the project are 1 to develop a demonstrator with optimized and robust performance suited for instrument demonstration and application exploration 2 to validate the technology with early adopters in early stage drug discovery and development and chemical synthesis companies 3 to develop a feasible business model and gotomarket strategy to be implemented by the startup fass brings a sustainable solution to the pharmaceutical and chemical industries reduce chemical and electrical consumption and through a dedicated startup will create jobs foster competition and contribute to the growth of the pharmaceutical industry and the european economy
reconstruction of specialized metabolite evolution through molecular switches

novel traits can provide fitness advantages and drive evolution new specialised metabolites are traits that arose in different plant lineages and even replaced existing metabolites why and how almost universal metabolic pathways can be replaced in entire groups of species by biochemically distinct pathways without persistence of any species producing both metabolites remains unknown components of gene regulatory networks that control such pathways might act as regulatory switches that flip between pathwaysthe replacement of the widely conserved red pigment anthocyanin by the biochemically distinct betalains offers a unique opportunity to understand the integration of novel traits into existing regulatory systems notably no plant species producing both anthocyanins and betalains has yet been identified but both show similar environmental responses the unification of systems biology with population and molecular genomics allows to elucidate the role of gene regulatory networks and regulatory switches in metabolite evolutiongiven the great importance of understanding evolutionary innovation and the potential use for metabolic engineering our work promises to be groundbreaking and have profound impact on many different fields of evolutionary and genetic researchspecifically our work plan includes the following aimsi identify regulatory networks and switches that enabled the exchange of metabolic pathways ii analyze the fitness consequences of reciprocal pathway exchange and regulatory switchingiii reveal the shortterm selection consequences of metabolites during the domestication of food cropsunderstanding how metabolic pathways can be exchanged in plants will provide insights into the important embedding of evolutionary innovation into existing systems with potential practical applications for crop improvement and bioengineering