Dragon09/odtu_chatbot huggingface dataset:
decisionmaking framework and processes for holistic evaluation of environmental and climate policies

the dual climate change and biodiversity crises put an urgency for implementing inclusive just and effective policies while their inextricable nature calls for integrated assessment approaches that capture synergies and tradeoffs mainstream economic methods currently used in the appraisal of environmental policies fail to capture the complexity of the climatebiodiversityeconomy nexus even though uncertainty disruption and irreversibility are inherent to environmental challenges these are overlooked when designing and evaluating the performance of policies policy effectiveness and resilience against other impact areas such as quality of life financial stability political feasibility innovation is not included in policy appraisal rather policy evaluation is informed by a narrow set of metrics falling short of encompassing broader considerations of sustainability and wellbeingdecipher employs a systems and multidisciplinary approach using a diverse set of models methods and processes to significantly improve decisionmaking on climate change and biodiversity and enhance policy resilience and feasibility moving beyond stateoftheart we will establish a holistic and operational decisionmaking framework that integrates advanced economic and biophysical models empirical methods and stakeholder participation tools the novel framework incorporates environmental damages in the economic decisions of agents and introduces a riskopportunity approach for decision making to offer critical insights on system dynamics and risks the models developed will be equipped with innovative features including improved representations of agent behavior technology innovation financial risk valuation and the capacity to assess extreme events and critical tipping points the new decisionmaking framework will be the endresult of an iterative cocreation process with stakeholders and applied under realworld conditions in the assessment of flagship eu policies
unravelling evolutionary responses of lagomorphs to climate perturbations geohistorical data integration for presentday biodiversity conservation

the lagomorphs rabbits hares and pikas are a successful mammalian group which play key roles in many ecosystems sustaining other species communities and populations the ongoing climate change is pushing most of their species into the extinction and their demise can entail the decline of their communities and ecological systems consequence of a dramatic knockon effect the present project revobbit aims to contribute to search solutions to this severe challenge from an unexplored perspective in this mammalian group the conservation palaeontology through the study of the bone and teeth of extinct lagomorphs it is possible to reveal the biological strategies and evolutionary shifts of those species or populations that were resilient and survived to past global warmings and coolings this is a very significant knowledge to be considered in the conservation decisionmaking process of extant relatives with this ultimate goal revobbit will study the extinct rabbits and hares from sierra de atapuerca pleistocene which endured important glacial and interglacial periods using trusty morphological methods and frontier molecular and geochemical techniques teeth and postcranial bones will be assessed disclosing their weight diet genetic size and diversity as well as the past environmental conditions where they lived temperature humidity etc the subsequent statistical analysis will let to identify the most significant ecological stressors and drivers that were involved in the evolution of lagomorphs the results obtained in revobbit will be the first step to build a big deeptime database of the lagomorph palaeobiology and to develop predictive models of biotic response at present the significant knowledge gap in the palaeobiology and palaeoecology of this mammalian group prevents that palaeontological data will be considered in the protocol conservation design of extant relatives
strengthening epidemiological genomic and community surveillance of mpox virus mpxv at the congo river border for drc and roc

the spread of mpox virus mpxv in subsaharan africa specifically democratic republic of congo drc and republic of congo roc presents an urgent public health concern with global implications mpxv cases have been reported across 114 countries with 89752 confirmed reports and 150 deaths it has the highest prevalence in drc and has resulted in twice the number of deaths in the african region compared to europe roc a drc bordering country is also experiencing a surge in positive cases highlighting an urgent need for datadriven efforts to identify transmission routes and implement public health initiatives mpoxprobe is responding to this call for action with an international consortium and activities in three main pillars 1 improving epidemiological surveillance of mpox with new diagnostics and sampling efforts including highrisk areas and vulnerable populations 2 capacity building to improve diagnostic and research capacities of researchers and public health workers in drc and roc 3 strengthening public health response by sharing surveillance data and newly developed spatiotemporal risk and transmission models for mpox through mpoxprobe this consortium will create actionable data to uncover mpxv transmission routes and natural reservoirs facilitating development of effective interventional packages the transmission and risks models will allow prediction of future or emerging outbreaks and develop initiatives to prevent further spread together these efforts will benefit vulnerable populations and general public in subsaharan africa alike while also performing groundbreaking research to understand transmission mechanisms
marte marine technology excellence hub for sustainable blue economy in baltics

the marte project aims to facilitate sustainable blue growth in the baltic region by establishing estonian and latvian marine innovation excellence hub this will be achieved through the collaboration of diverse stakeholders including academic institutions taltech university of tartu ventspils university of applied sciences latvian institute of aquatic ecology public sector environmental investment centre kurzeme planning region saaremaa development centre latvian investment and development agency industry association of estonian marine industries port of ventspils and coastal communities wwf baltijas krasti saarte koostkogu by leveraging quadruplehelix collaborations marte will create a crossborder innovation strategy and supportive network for fostering new technologies throughout the marine industry value chain project objectives include collaborative rd ecosystem empowerment and policy influence for advancing marine technologies reinforcing stakeholder linkages improving ecosystem capacity building closing the knowledge gaps supporting smes and startups and elevating the visibility of the regional blue economy innovation ecosystems in alignment with eu green deal and regional smart specialization strategies the strategic framework focuses on marine technology innovation uptake in areas like offshore energy smart vessels and ports sustainable use of marine resources and marine ecosystem protection through a comprehensive approach encompassing stakeholder engagement and capacity building marte strives for a significant impact on the sustainable blue economy in baltics
singlechip integration of mems micropumps with optical waveguides for laser absorption spectroscopy

microbiological research is concerned with studies of microbial gas consumption and production which is tightly linked to natural greenhouse gas emissions but also sinks currently such studies require large and expensive instrumentation like gas chromatography systems which also sacrifice the sample during each measurement this affects the conditions of the sample and yields unsatisfactory temporal resolution due to the need for sample handling in this project i propose to leverage the latest advances in mems and nanophotonics to develop the first chip platform integrating optical waveguides with micropumps which will facilitate tuneable diode laser absorption spectroscopy tdlas under vacuum and in closed valume without sacrificing the sample gas with the addition of lasers and light detectors it will enable inexpensive low weight portable devices for realtime in situ trace gas detection such device will not only impact microbiological research but also sensor networks much needed eg in cities for controlling the air quality
role of tissueresident folr2 macrophages as organizers of the tumor immune microenvironment

the infiltration of cd8 t cells in tumors is crucial for the development of immunity against cancer we have recently identified a tissueresident macrophage population expressing the folate receptor 2 folr2 and infiltrating human and murine breast tumors we have shown that tumorinfiltrating cd8 t cell form lymphoid aggregate around folr2 macrophages in a perivascular niche the abundance of folr2 macrophages associates with lymphocyte infiltration the onset of tertiary lymphoid structures tls and favorable prognosis the abundance of tls in cancer correlates with better prognosis and clinical response to immunotherapy yet the molecular and cellular cues underlying tls formation in tumors are ill understood here we hypothesize that folr2 macrophages locally shape the compartment of tumorinfiltrating cd8 t cells mechanistically we will address if folr2 macrophages spark local cd8 t cell responses directly by interacting with t lymphocytes or indirectly by fostering tls formation to this end we will 1 develop a high dimensional analysis of the folr2 macrophageperivascular niche using tissue imaging spatial transcriptomic and singlecell rna sequencing 2 implement a new murine genetic model developed in the lab enabling the inducible ablation of folr2 macrophages and conditional gene inactivation 3 deliver a mechanistic analysis of cellular crosstalks involving folr2 macrophages and supporting the development and maintenance of tls lastly we will explore new immunotherapy strategies harnessing the immunogenic function of folr2 macrophages purposed to induce antitumor cd8 t cell responses to this end we will use antibodymediated targeting of folr2 macrophages to increase antigen presentation andor innate activation this study will provide fundamental insights on how tissueresident macrophages regulate tumorimmunity and a proof of concept for macrophage subsetspecific therapeutic interventions to treat cancer
fishx providing a european fisheries dataspace through a consultative approach

developing a fisheries dataspace fishx and insight platform based on smart orchestrated architecture and open interoperable technology via gaiax that will enable users to implement data to improve fishing methods increase yields protect endangered fisheries stocks and streamline mcs processes supporting the implemntation of the cfp the project will also be developing a series of industry and fisheries agency to consultatively participate in developing and refining new technologies in light of the changes and review of cfp
identifying cellular and molecular features of protective antimalaria b cell response

malaria is one of the leading lifethreatening diseases with a reported 627000 deaths and 241 million infections in 2020 mostly in lowincome countries despite the advances gained by control measures malaria incidence by plasmodium falciparum pf has plateaued in the last decade intervention through vaccines and antibody therapy shows promising results yet longlasting protective immunity remains unattainable antimalaria memory b cells comprise transcriptionally distinct subpopulations but their contribution to protective immunity is unclear here i plan to combine stateoftheart strategies to identify the cellular and molecular features of protective immunity offered by b cells and encoded antibodies respectively to that end i will use the unique samples from controlled human malaria infection trials to isolate memory b cells reactive to pf antigens obtain transcriptome and immunoglobulin ig gene sequences at the single cell level and measure antibody inhibitory properties at the monoclonal level transcripts signifying resting activated or exhausted phenotype will allow memory b cell clustering whereas ig gene features will help define clonal expansion and selection strength of antibodies by cloning and testing antibodies in specialized in vitro and in vivo assays i aim to discover potent inhibitory antibodies targeting different parasite developmental stages i will reveal the protective antibody molecular properties defined by ig gene features affinity and epitope specificity by singlecell level integration of transcriptome and antibody functionality for the first time this project will not only deliver potent parasite inhibitory antibodies of therapeutic potential but also lay a clear blueprint for attaining protective immunity through future vaccine designs this fellowship will support me in acquiring interdisciplinary expertise and advancing my career as a leading scientist in b cell immunology and malaria vaccinology
innovative and safe microwavebased imaging technology to make breast cancer screening more accurate inclusive and femalefriendly

breast cancer bc is the most common cancer in women worldwide affecting 1 in 8 women the figures from whos international agency for research on cancer estimate that in 2020 worldwide cases of breast cancer accounted for 24 of all cancers in women 226 million women and 685000 deaths globally mammography is the gold standard technology for breast screening which has been demonstrated through different randomized controlled trials to reduce breast cancer mortality however it has limitations and potential harms such as the use of ionizing radiation breast compression and performance restrictions due to the intrinsic nature of xrays in particular breast density is a restrictive property that can prevent breast cancer detection in mammograms of women with radiographically dense breasts other existing techniques mri ultrasound biopsy also suffer from drawbacks the overall aim of the mammoscreen proposal is to generate evidence about the use of mammowave a technology developed by ubt as screening technique in populationbased programs promoted by national or regional health systems to reach a revolution in breast screening to do so the consortium aims to confirm that mammowave reaches sensitivity90 and specificity95 in bc detection on 10000 study participants undergoing regular screening programs mammowave uses safe noninvasive and nonionizing microwave signals does not apply any compression to the breast and is very effective with dense breasts hence it can extend the breast screening to younger women aged 2049 98 million women in europe this group accounts for 30 of breast cancers in 2020 a comprehensive health economic assessment will be undertaken in this project and innovative way to implement patient engagement approaches is sought an effective policy makers engagement plan will be carried out to ensure that mammowave is recommended as screening approach due to the benefits that it brings to women and healthcare systems this action is part of the cancer mission cluster of projects on prevention including screening
health safety and ergonomics for the future humancentric factory

msds are inflammatory andor degenerative ailments affecting all sectors and all categories of workers and are by far the most common workrelated health problem in the european industry the biggest europewide occupational health survey found 46 of european workers reporting back pain while 43 had painful shoulder neck and upper limb muscles the social and economic consequences of this pandemic are now becoming clear msds accounted for 53 of workrelated diseases in the eu15 affecting 100 million people and causing half the absences from work and 60 of permanent work incapacitytotal cost of lost productivity attributable to msds is 2 of gross domestic product in the eu 240 billionhego is an innovative solution based on a proprietary set of motion capture algorithms able to recognize the workers gender age posture and movements in realtime and monitor ergonomics to adapt both workspace and workload according to workers personal profile to inform about potential msds risks and to provide insights for improving the work environments without the use of wearable devices and thanks to an automatic analysis of ergonomic risk factors hego can detect any incorrect posture of the worker or risky situations suggesting to operators the corrective actions the performance of the system is outstanding and has been validated in industrial facilities accuracy in recognition of skeleton points and movements 85 true positives and true negative in the recognition of an incorrect posture 90 data synchronization times 05 sec hego contributes to promote health and safety in industrial workplaces humancentered manufacturing concept by providing a low cost and reliable solution
2d materialbased multiple oncotherapy against metastatic disease using a radically new computed tomography approach

perseus intends to implement a novel nanotechnologybased cancer therapy for deepseated clinically unmanageable drugresistant and metastatic tumours practical use of nanotechnology in clinical cancer care is still in its infancy with a full potential yet to be realized the therapy is based on a novel nanosystem ns made of multifunctional 2d layered nanocrystals the ns enables under activation by computed tomography ct an effective multimodal therapy with minimal or no adverse effects this novel paradigm uses ct not to eradicate cancer but to trigger and to image the ns that locally activates nonmutagenic oncotherapies the therapies delivered are excited by the conversion of low energy xrays ie ct into heat reactive oxygen species and radiosensitizing agents xray irradiation can also induce immunogenic cell death with the exposure or release of neoantigens to trigger an anticancer immune response the use of xrays makes it possible to reach deepseated tumours that are inaccessible by visible or nearinfrared lightbased therapies in other words ct is the spark that lights the match this is a radical vision for an ambitious and highrisk project the current proposal targets a range of cancer types including metastatic triple negative breast cancer hepatocellular carcinoma colorectal cancer pancreatic ductal adenocarcinoma the ns is biocompatible and also totally inactive in absence of ct radiation ie the ns becomes active only where the ct beam is delivered so minimizing side effects at distal sitesthe therapy is agnostic to the type of cancer and to gender incidence because it doesnt affect the body biochemistry this is a second change of paradigm perseus vision is pursued by a multidisciplinary team composed of physicists chemists chemical engineers biologists physicians pharmacologists and radiologists working together to develop an innovative nanotechnological approach to address unmet clinical needs
sensitive periods for audition teenagers with normal hearing hearing loss

orienting oneself in a crowded playground understanding the teachers explanation despite the surrounding chatter lipreading to support auditory perception in noisy backgrounds these are all complex but essential skills for navigating lively schools in children with normal hearing the auditory system is functionally mature by 6 months of age yet complex auditory processing remains immature until mid to late adolescence strikingly adolescence is characterized by the onset of puberty which triggers a cascade of hormonal changes that drive neural plasticity and viceversa the overarching hypothesis of sensationahl is that adolescence might present a second sensitive period for complex auditory processing just like puberty is a gradual process spanning years sensitive periods unfold over time in this project i propose a multimethod approach to advance our understanding of maturation of complex auditory processing at adolescence specifically i will combine neuroendocrinology neuroimaging and psychophysics to identify the mechanisms that govern sensitive periods as they unfold over time first i will zoom in on the onset of puberty as a potential trigger for heightened plasticity associated with sensitive periods next i will investigate the effect of altered auditory input due to hearing loss noise exposition or auditory training on maturation of complex auditory processing in adolescents last i will focus on the braking factors that contribute to a decrease in plasticity observed at the end of adolescence sensationahl uses an innovative multidisciplinary perspective to tackle a remaining challenge in the field of developmental auditory cognitive neuroscience it will have significant impacts on public health ie prevention and clinical management of hearing loss language education ie speech perception in challenging backgrounds in children and theoretical understanding of sensitive periods across the lifespan
increasing excellence in utilizing xray research and neutron scattering techniques at the university of tartu

university of tartu utartu is the top research university in estonia and the baltic states the twinning project exanst increasing excellence in utilizing xray research and neutron scattering techniques at the university of tartu is concerned with further raising the research profile of utartu in the field of materials science by enabling researchers from utartu to take full advantage of the best european facilities for materials characterizationin particular the aim of this twinning project is to develop local expertise at utartu in the xray research techniques and neutron scattering techniques that are available at leading european synchrotrons and neutron facilities another aim of the project is to enhance expertise at utartu in the complementary computational methods that are used for materials modelling and analyzing the data generated in xray and neutron experimentsin order to achieve these aims utartu will team up with three advanced partners max iv sweden an advanced partner in synchrotron science forschungszentrum jülich fzj germany an advanced partner in neutron science and imperial college london icl uk an advanced partner in materials modelling besides the researchorientated endeavours the advanced partners will also provide guidance to utartu on research management strengthening cooperation between different institutes within utartu and tackling gender and diversity issuesas part of the twinning project utartu and the advanced partners will jointly carry out three pilot research projects concerned with i solidelectrolyteinterphases formed in energy storage devices based on ionic liquids ii photoactive proteins that can serve as optical switches or tuneable fluorescence markers and iii scintillator materials for radiation detection devices the pilot projects will give researchers from utartu an opportunity to gain firsthand experience in specific xray and neutron methods and modelling techniques