Dragon09/odtu_chatbot huggingface dataset:
solid state battery smart structural modular integration into vehicle through flexible module to chassis design

s4mile project aims to support the largescale introduction of electric vehicles by simplifying the vehicle structure and integrating the nextgeneration solidstate cells into the vehicle structure based on a disruptive and innovative virtual moduletochassis concept vm2c based on large structural alu casting and composite unibodies the size of the permanently installed battery is reduced using a novel swappable module design to increase the gravimetric and volumetric energy density of the unit in a safe and robust design the solidstate technology coupled with advanced thermal and pressure management systems enables fast charging and longrange based on a reconfigurable battery management system bms which facilitates maintainability reparability and second life and ensures modularity and scalability of the design applicable to a range of small to medium size vehicles through a safe and efficient communication and operation with the vehicle controller advanced battery models based on a battery passport coupled with a thermal management system in a digital twin of the battery will ensure optimal operation and life and range extension while ensuring safety in all operating conditions s4mile builds upon large experience and prior projects to meet outstanding results capable of boosting the eu landscape in evs and related sectors
how the physical environment shapes the human brain

brainscape constitutes a timely approach to study a widely unexplored aspect in the neurosciences namely whether and how the physical environment that surrounds us day in day out impacts our brain wellbeing and mental health brainscape aims to spearhead the emerging field of environmental neuroscience and will make an impact by building a knowledge base for evidencebased urban planning to promote healthy living environments with significant practical implications given that our environment is undergoing rapid changes urbanization climate change understanding how these changes may impact humanity is a crucial challenge of our time first evidence suggests that longterm as well as daytoday variations in exposure to solitary environmental factors eg air pollution may be relevant the goal of brainscape is twofold 1 to identify the active ingredients of the environment by introducing a more holistic understanding of the environment as a multilayered complex phenomenon and 2 to gain insight into the pathways and mechanisms by which the environment affects the brain and mental health to accomplish this brainscape will utilize existing largescale crosssectional and longitudinal neuroimaging data sets uk biobank nako hchs imagen to identify the most important features of the physical environment these features will be at the core of prospective controlled studies including a discordant monozygotic twin study here we will combine the assessment of objectively experienced eg wearable sensors and subjectively perceived environment with brain plasticity measured using 7 t mri the identification of the most influential environmental salutogenic features will inform a targeted intervention study and experiments in highly controlled lab environments using innovative vr technology combined with fmri and fnirs the results will unravel the active ingredients of nature and the neural mechanisms by which they affect human beings
palladium recovery for co2 valorisation

critical raw materials crm incl platinumgroup metals pgm are key to enable europe to meet its 2030 climate and strategic autonomy objectives global demand is constantly growing for crm the diversification of eu supply is thus imperative to reduce dependencies and improve eu capacity to rely on sustainable value chains parcovals aim is to leverage the recognised catalytic capabilities of radioactive pgm specifically the palladium pd to demonstrate their potential for use and market parcoval will create 2 circular loops from 2 wastes 1 recover pd from spent nuclear fuel today vitrified and considered a nuclear waste and 2 reuse the co2 produced by an existing industrypd will be extracted from streams generated in a spent nuclear fuel recycling plant and valorised as catalyst to perform co2 electroreduction into co performances achieved into co conversion will be compared between radioactive pd and natural pd catalyst at industrial scale 100cm2 electrodes integrated in electrolyser catalytic mechanisms involved will be studied to explain the contribution of radioactive radiation during co2 reduction the co2 will be supplied by industrial production units of anaerobic digestionfocus will be on the characterisation of the co generated and the nonradioactive gas contamination to consider a transfer into a nonnuclear environment plant will also be demonstrated a use case to valorise the co will be studied to produce succinic anhydride which can be incorporated in polyesters through copolymerisationparcoval will conduct a life cycle analysis to compare environmental impacts of using radioactive pd and mining extracted pd to produce succinic anhydride moreover a preliminary business model will be performed and the market potential of target group will be defined parcoval will also issue bestpractice framework to ensure the safety and security of pgm use in the industry including radioprotection traceability and collection after use
testing the paradigm of a single plastid origin in eukaryotes

photosynthesis was acquired by eukaryotes through endosymbiosis with cyanobacteria which resulted in new cellular organelles the plastids from the origin of plastids evolved the first eukaryotic algae giving rise to land plants but also triggering the evolution of most photosynthetic eukaryotes by subsequent endosymbioses between these first algae and other eukaryotes thus the origin of plastids profoundly changed the course of eukaryotic life by being the launching point that shaped the biological diversity of most primary producers despite this importance our understanding of how plastids originated remains largely uncertain the current paradigm describes this transformative event as a single primary endosymbiosis but i argue here that critical data is lacking notably from the vast hidden environmental diversity of microbes to adequately test this hypothesis in this project i propose to gain insight into the origin of plastids by addressing the main questions 1 what is the currently hidden diversity of highranked taxa related to primary photosynthetic lineages 2 what are the feeding behaviors of these taxa and are they aplastidic 3 are some lineages genetically predisposed to establish plastids from the acquisition of foreign genes 4 what was the composition size and origin of the ancestral primary plastid proteomes to answer these questions i will link third generation environmental sequencing transcriptomics and genomics to cell structure and behavior of novel key lineages related to primary algae and produce crucially missing plastid proteomes to allow comprehensive comparative proteomic analysis my project will not only have immediate implications on our understanding of the origin of plastids and more generally the fundamental process of endosymbiosis but the approaches developed will be a test bed for future global studies aimed at understanding the evolution and ecology of the microbial majority of complex life
ancient irrigation detection and analysis using advanced remote sensing methods

ancient irrigation systems are probably the first human largescale landscape modifications the analysis of the ancient irrigation systems that gave rise to and sustained the first urban civilisations goes wellbeyond the study of ancient irrigation to touch topics such as climate change sustainability population dynamics and ancient economy all at the core of urbanisation as a deeply human phenomenon perhaps the most important change in the history of humanityfor many decades ancient water management research in archaeology was mainly focused on the near east and surrounding regions with similar hydroclimatic conditions the political situation in that region and as a consequence the lack of new data nearly stopped further scientific activities the relevance of this research topic however did not decrease and many methods for the study of ancient irrigation and water management using remote sensing haven been developed during the last yearshowever most previous approaches are regionfocused lacking applicability to other environments and have mostly detected isolated channels which complicates the study and understanding of the network that constituted ancient irrigation systemsunderthesands will employ a combination of novel remote sensing techniques including multiscale relief model seasonal multitemporal vegetation indices hybrid machinedeep learning algorithms archaeomorphology spatial correlation indices and historical analyses and sources including multispectral imaging synthetic aperture radar and tandemx to produce a workflow for the detection and analysis of ancient irrigation networks in diverse environments these methods and the training provided during their implementation by a team of leading international researchers will enhance the candidates profile with cuttingedge techniques that will situate him at the forefront of research in ancient irrigation and boost his career
building bridges between earth observation and environmental sciences

unprecedented humaninduced changes in climate and biodiversity are increasingly threatening nature human life and wellbeing around the world earth observation eo has become one of the most important methods for regularly obtaining standardised information about the earths environment and is therefore essential for addressing climate change biodiversity loss and other societal challenges however the full utilisation of eo is still limited this is especially due to 1 a lack of experts in the field of eo with background in environmental sciences as well as 2 a lack of general awareness of the potential of eo in the field of environmental sciences or policy support and implementation universities play an essential role in bridging such knowledge and communication gaps by conducting research developing new methods and training new professionals the proposed project earthbridge aims to i substantially increase the interdisciplinary research capacity of the czech university of life sciences prague czu in the field of environmental eo ii and to further improve the use of environmental eo tools by a wider community through twinning with three internationallyleading universities technische universitt dresden tud and rheinische friedrichwilhelmsuniversitt bonnc ubo in germany and alma mater studiorum universit di bologna unibo in italy earthbridge focuses on the development and application of environmental assessment methods for monitoring restoration and conservation of biodiversity in agricultural landscapes a research topic of high relevance to europe the project will benefit from ongoing research activities that will feed into it existing eo data ways to achieve the bridging will include staff exchanges scientific training and training to prepare research proposals organisation of summer school and scoping for a joint study programme a synthesis project for earlycareer researchers and involvement of regionalnational institutions according to their needs or requirements
geometric and lowregularity integrators for the matching and preservation of structure in the computation of dispersive equations

if mathematics is the language of physical sciences differential equations are their grammar yet to understand them we need computational algorithms some of the most intriguing phenomena in nature arise when the underlying physical laws can be described using nonlinear dispersive partial differential equations this means that waves of different frequencies travel at different speeds a mechanism that is for instance responsible for the breaking of ocean waves near the shore when a computer is asked to approximate solutions that exhibit discontinuities lowregularity as is the case for instance in shock waves these nonlinear frequency interactions pose a significant challenge which has recently been addressed by the development of socalled resonancebased numerical schemes in many applications it is desirable to apply geometric numerical integrators algorithms that preserve geometric structure of the underlying equation such as conservation of energy or time reversibility however there is only a very limited set of methods available that can address both challenges in unison ie perform well in lowregularity regimes and preserve geometric structure of the underlying differential equation such algorithms if more widely developed would provide a valuable tool for a range of applications including extreme events in ocean waves and atmospheric models the goal of this proposed research is to address this need for structurepreserving lowregularity integrators for dispersive partial differential equations the proposed project lies at the interface of computational mathematics analysis and physical applications and if successful the results of this proposal have the potential to enhance both our current understanding of numerics for dispersive equations and in the medium term improve practical simulations which are used in weather forecasting and efficient disaster prevention from extreme ocean events
harnessing a novel crispr nuclease for programmable counterselection in human cells

crispr technologies have revolutionized genome editing in medicine agriculture biotechnology and lifesciences research with their ability to generate virtually any dna edit at any genomic site in any organism however editing frequencies can be restrictively low requiring extensive screening to identify cells harboring desired edits what remains elusive is a way to greatly boost the frequency of editing while characterizing crisprcas systems bacterial defense systems and the source of crispr technologies we discovered a new mechanism that could kill unedited cells yet spare edited cells regardless of the type of gene edit this versatile and sequencespecific approach can be described as programmable counterselection as undesired cells are targeted for removal and those cells can be targeted in a programmable way if proven this capability could radically boost the effective editing frequencies by removing unedited cells regardless of the underlying edit providing muchneeded relief to the burden of screening imposed on diverse genomeediting applications here we propose to perform proofofconcept experiments demonstrating this capability in human cells while exploring which editing applications would best benefit from this capability the associated tasks build on my extensive work at the interface of crispr biology and technologies and leverages his numerous academic and industrial contacts i ultimately aim to translate a novel biological insight from my groups erc consolidator project into an innovative foundational technology with a clear path toward its broad use in genome editing
cluster for innovative energy clusterinn

energy generation and use obtained new urgency the last year when russia invaded ukraine european and other countries encountered harsh realities when problems related to energy availability and affordability had to be tackled an urgent need for faster and more efficient transitioning towards renewable sources is evident the project proposal lies within priority research and innovation it intends to bring together the scientists and practitioners and involve experienced researchers and earlystage researchers in social sciences electrical engineering physics and environmental sciences scientists will interact with managers of largescale solar park clusters in egypt and morocco which would allow understanding specifics and scale of problems related to renewable energy production use and trade an interdisciplinarymultidisciplinary approach here may lead to novel solutions which may have important policy implications we intend to build a cluster for innovative energy which will involve other clusters already created in the former horizon 2020 and other projects the cluster for innovative energy would be a cluster of clusters allowing broad engagement of scientists practitioners policymakers ngos and other stakeholders in the context of the war innovative solutions stemming from the intersectoral cooperation of geographically remoted partners can become resilience drivers the project is based on previous work but goes beyond since it generates and strengthens longterm collaborations via training researchers encouraging geographical mobility and fostering exchange between sectors and disciplines
art of darkness as cultural heritage of urban landscape

the art of darkness as cultural heritage of urban landscape art of darkness project aims to preserve and develop cultural heritage sites throughout europe with a better understanding of the cultural aesthetic and sustainability values of darkness which are important to the wellbeing of humans and nature the project raises awareness of and explores wellconsidered darkness with highquality architectural lighting design and light art as an asset in relation to cultural heritage which can be cherished and harnessed to boost culturalled innovation and attract strategic investments to cultural heritage and cultural and creative industries cci this is achieved through creating a europewide collaborative network of 3 cities 5 research institutions and 2 societies which conduct 5 artistic pilot trials in cultural heritage sites in 5 countries the pilot trials develop design strategies and solutions for more sustainable aesthetic and socially feasible darktime experiences through codesign with local stakeholders the piloting process which consists of context mapping codesign pilot production and evaluation processes brings together researchers ccis professionals eg artists lighting designers architects citizens local societies and municipality actors thus methodology of the project is transdisciplinary participatory and integrative the disciplines included in the project consortium are architecture lightart cultural heritage urban design and planning lighting design photometrics engineering media and neurotechnology environmental psychology cultural anthropology scenography and performing arts importantly the evaluated results are integrated into the art of darkness piloting model to be replicated in other cities and regions and translated into roadmaps and policy briefs for further impact all values and working principles of the neb compass are implemented in the project work with the highest ambition level
defusing minichromosomesthe achilles heel of the wheat blast pandemic

pandemic is an ambitious highriskhighgain program to deliver an innovative pathogenguided strategy for crop disease resistance the wheat blast pandemic is a clear and present danger to global food security it is caused by the blast fungus magnaporthe oryzae which after emerging in brazil only 35 years ago has spread over the last 5 years to southeast asia and africa we discovered that all isolates of the pandemic wheat blast fungus belong to a single asexual clonal lineage these pandemic isolates carry a supernumerary minichromosome mchr of 2 mb which encodes 19 secreted effector virulence proteins and renders the pandemic lineage highly virulent we propose that this mchr is the achilles heel of the pandemic fungus in pandemic my team and i will target the mchr virulence properties by gene editing and engineering of disease resistance genes that target mchrencoded effectors the central hypothesis of this project is that detailed knowledge about the biophysical properties of pathogen effectorhost target interactions can guide bioengineering of nontransgenic disease resistance in wheat to achieve our goal we will employ a multidisciplinary approach combining genetics structural biology and gene editing specifically we will pursue the following objectives1genetics determine the mchrencoded effectors conferring high virulence on the pandemic wheat blast fungus 2biophysics define the biophysical properties of effectorhost target interactions3immunity apply crisprcas gene editing to deliver innovative nontransgenic solutions for blast disease managementat the completion of this project my team and i will generate a detailed understanding of the biophysical properties of mchrencoded effectortarget protein complexes and deliver novel traits and nontransgenic solutions for developing resistance against the pandemic wheat blast fungus
fostering artificial intelligence trust for humans towards the optimization of trustworthiness through largescale pilots in critical domains

the increasing requirement for trustworthy ai systems across diverse application domains has become a pressing need not least due to the critical role that ai plays in the ongoing digital transformation addressing urgent socioeconomic needs despite the numerous recommendations and standards most ai practitioners and decision makers still prioritize system performance as the main metric in their workflows often neglecting to verify and quantify core attributes of trustworthiness including traceability robustness security transparency and usability in addition trustworthiness is not assessed throughout the lifecycle of ai system development so developers often fail to grasp a holistic view across different ai risks last the lack of a unified multidisciplinary ai data and robotics ecosystem for assessing trustworthiness across several critical ai application domains hampers the definition and implementation of a robust ai paradigm shift framework towards increased trustworthiness and accelerated ai adoption to address this critical unmet needs faith innovation action will develop and validate a humancentric trustworthiness optimization ecosystem which enables measuring optimizing and counteracting the risks associated with ai adoption and trustworthiness in critical domains namely robotics education media transport healthcare active ageing and industrial processes through seven international large scale pilots notably crossfertilization actions will create a joint outcome which will bring together the visions and specificities of all the pilots to this end the project will adopt a dynamic risk management approach following eu legislative instruments and enisa guidelines and deliver tools to be widely used across different countries and settings while diverse stakeholders communities will be engaged in the each pilot delivering seven sectorspecific reports on trustworthiness to accelerate ai takeup