Dragon09/odtu_chatbot huggingface dataset:
the onestopshop of accessible circular solutions for sustainable tourism

the european tourism sector plays a pivotal role in driving economic growth employment and social development however it faces challenges deriving from its predominant reliance on linear models causing significant environmental impacts and resource depletion recognizing the necessity for a paradigm shift the verne project aspires to accelerate the transition of local and regional tourist destinations toward sustainable and circular models across europe verne aims to provide an integrated framework for analysing the feasibility and impact of circular interventions in tourism destinations offering recommendations for authorities tourism industries and citizens for the sectors transition into more sustainable business models in collaboration with public administrations dmos private sector services industries citizens and tourists ngos and other stakeholders verne will create and validate a range of systemic replicable and scalable solutions tailored on the real needs and attitudes of these actors these solutions will encompass diverse approaches and technologies ie digital solutions improved waste and food waste management wastewater treatment use of electric vehicles etc and will cover several sector and services for tourism the verne solutions will be implemented and demonstrated in 5 european representative tourist destinations verne pilots the projects outcomes will be incorporated into new business models providing a quantified demonstration of their effects on the competitiveness and sustainability of existing tourism services finally verne will have the ambition to emerge as onestopshop for sustainable tourism serving as a comprehensive hub of expertise tools and best practices on sustainable tourism facilitating the adoption and replication of circular systemic solutions across europe
deciphering circulating signatures of infected pancreatic necrosis

acute pancreatitis is a common disease that can progress to gland necrosis necrotizing pancreatitis np np imposes significant risk of morbidity mortality and substantial healthcare costs especially when infected infected pancreatic necrosis ipn a preemptive approach with early ipn recognition is suggested to improve patient outcomes however existing diagnostic tools fail to distinguish ipn from sterile np early in the disease course furthermore related studies on potential serum markers lack sufficient methods of assessment the aim of this project is to develop a simple reliable and costeffective biomarker panel for accelerated and improved decisionmaking validated on real patient results first we use information theory and machine learning to select the bestperforming combination of available serum cytokines for detecting ipn the accuracy and prediction abilities of the biomarker panel are then verified in an independent cohort using the standardized prospective specimen collection retrospective blinded evaluation study design for pivotal evaluation of biomarkers finally the net benefit to patients and costs by incorporating effects of clinical decisions based on the panel is assessed through a multicenter randomized controlled trial the project creates a critical step in the improvement of care and clinical management in millions of patients worldwide moreover the systematic phased approach facilitates open science and reproducibility as the panel moves from research to application it offers potential for commercial exploitation in the longer term if clinically validated the test can be adopted by the larger clinical community for further research and more personalized care
cmxsafe a novel cloudbased secure communication architecture to simplify emerging iot regulatory compliance

security in internetofthings iot environments has become a major concern this is partly due to a large number of remotely exploitable iot vulnerabilities in service authentication and access control combined with the lack of timely technical support furthermore emerging regulations require changes in iot deployments difficult to apply in a generalisable fashion this difficults reusability and scalability and increases development and management costs therefore the objectives of cmxsafe are twofold a provide a proxylayer communication architecture devised to offload security communications functions from iot applications into applicationagnostic proxy modules this simplifies iot device application designs and the deployment of security updatesb devise cmxsafe components abiding by the security evaluation standard for iot platforms sesip methodology accepted by the european committee for standardization to facilitate composite cybersecurity certification schemesto accomplish this i will describe the technical requirements according to the sesip standard and implement a testbed comprising 8 iot devices and the cloud side of cmxsafe architecturethese activities will take place at the university college of dublin school of science at the aseados lab where i will be supervised by prof anca delia jurcut cmxsafe will allow me to improve my competencies in cybersecurity regulations cloud architectures and valuable transferable skills required to succeed in the industrycmxsafe will guarantee a successful twoway transfer of knowledge because cmxsafe combines my background experience in security decoupled communications with the hosts experience in cybersecurity regulations and business relations with industry partners therefore cmxsafe will contribute with an iot proxybased communication architecture that facilitates security updates and regulation compliance
car t cells rewired to prevent exhaustion in the tumour microenvironment

although immunotherapy of select hematological malignancies using chimeric antigen receptor car redirected t lymphocytes has recently gained regulatory approval successful treatment of solid tumors using car t cells remains elusive one salient problem is the limited efficacy and untimely exhaustion of car t cells in the tumor microenvironment tme combining innovative methods of genome editing chemistry and immunology car trex proposes to explore a novel concept of building autoregulated genetic circuits into car t cells to selectively circumvent their exhaustion upon activation in the tme genetic rewiring will be achieved by precisely inserting artificial mirnas under endogenous exhaustionrelated driver promoters to downregulate target genes that cause exhaustion proprietary technology enables specific replacement of the driver gene without risking offtarget mutations further advantages of combined insertion and silencing are i the ability to regulate when a gene is turned onoff by biologically and clinically relevant cellular cues and ii multiple geneknockdown with a single dsdna cleavage and rnasilencing of both alleles these genetic modifications will be implemented using a novel highperformance peptidebased gene delivery platform with unlimited loading capacity allowing combination of several types of cargo as well as economical large scale gmp production rewired her2neu erbb2 redirected car t cells will be tested on preclinical breast and gastric carcinomas and variants that eliminate tumors resistant to conventional 2nd and 3rd generation peers without adverse events will be developedmanufactured following qualitybydesign principles under gmplike conditions thus accelerating the pathway towards clinical translation these approaches will also constitute a proofofconcept for modifying therapeutic cell products with the potential to considerably improve their safety specificity efficacy scalability and cost
ismile integrated scalable microled engines

todays microelectronics is suffering from the fact that silicon cannot emit light otherwise technological road blockers like the communication bottleneck of microprocessors or like bulky displays hindering the rocket start of augmented reality could easily be overcome the eic accelerator project ismile will bring light to microelectronics our goal is to be an enabler for a natural integration of microelectronics with microphotonics ismile will establish a gan cleanroom in order to be completely independent from noneuropean manufacturers customized microled modules for arglasses will be a first product beyond that ismile will be the basis for establishing the worldwide first gan foundry making gan technology fully accessible to european innovators leading to a democratisation of microled technology much like tsmc from taiwan who is now the worlds largest foundry for silicon cmos technology we dream of qubedot developing into the tsmc for gan in the futureafter completion of the project qubedot will be able to produce microled displays and customerspecific microleds with the highest precision within its own clean room environment using iso9001 certified process flows with singleshift utilization the pilot line will be able to generate an output translating into potential annual sales of up to 25 m with an estimated margin of 30 while other very large companies do not adapt their production processes for mediumsize batches qubedot has understood the interaction of essential parameters in the processing of gan through intensive research and development work this enables the production of a wide variety of microled architectures in terms of quantity size shape emission color and packagewhile other very large companies depend on semiconductor manufacturers with production sites especially in asia or are themselves manufacturing in asia qubedot produces in europe at competitive conditions
superstition material religion and hıdrellez in turkey

this project will investigate the history of turkey in terms of religion rather than islam to understand the roots of the normative understanding of religiosity as sunniislamic the aim is to comprehend the western influence on religion and islam in turkey and to illuminate the history of material forms of religiosity by focusing on hıdrellez a religious practice that was and still is celebrated in a convivial manner by people of different ethnic and religious backgrounds while recent critical approaches in global religious history and material religion aim to overcome any eurocentrism that still persists in religious studies the case of turkey still remains largely unexplored situated at the intersection of religious studies and history this project will break new ground by bringing together a postcolonial history of superstition with the historical analysis of material religion and will advance global debates on how religion is discussed today through its critique of essentialist definitions of muslim majority nations the research objectives are 1 to examine the role of superstition in the categorisation of islam during the 1950s as a form of global entanglement between turkey and the west 2 to investigate the research on the history of religions and superstitions as a form of entanglement between turkey and germany 3 to empirically analyse the history of the diversity of religious life by focusing on hıdrellez 4 to analyse the transformation of hıdrellez from a religious practice to intangible cultural heritage superstitious will generate international collaborations and foster vibrant cooperation between scientific communities civil society representatives and citizens in the early years of the second centenary of the republic of türkiye it intends to lay the foundations for an awareness of religious pluralism and tolerance among its citizens and diaspora communities
eosc track implementing the european open science monitoring mechanism

eosc track will develop and operate the european open science observatory a policy intelligence tool that will monitor policies investments digital research outputs skills and infrastructure capacities related to the open science and the european open science cloud eosc its mission is to simplify and streamline monitoring in the european open science ecosystem to bring a common understanding on how to collect and interpret data appropriate for monitoring as well as to assist policymakers and research executives across europe in understanding shaping and aligning open science and related policies and their implementationstarting from the current eosc observatory developed during the eosc future project trl7 eosc track will transform the service into trl9 making it an open secure and trusted platform to serve as the goto place for open science monitoring europe it will enhance it with features to improve usability engagement and collaboration automate data ingestion from trusted sources such as the openaire graph incorporate collaborative editing and validation of data add interactive navigation and search visualisations it will complement with the eos resources registry which will serve as a learning tool by including narratives from experts to demonstrate the internal processes towards the os implementation in a country and stories for impact or best practiceeosc track will explore the sustainability of the eos observatory by fostering a codesign process with the eosc tripartite partnership and other interested stakeholders the objective is to align various monitoring initiatives offer practical assistance in data collection and generate 360o reports to establish a defacto hub for all information around monitoring open science and eosc in europe fast forwarding to 2027 eosc track will facilitate a dialogue with the eosc tripartite governance to develop a roadmap for ensuring longterm sustainability
quantum information science and ultrafast nonlinear coherent control at the attosecond timescale

understanding the interaction between electromagnetic radiation and matter is crucial for unravelling the internal structure and processes of materials electromagnetic waves exhibit both wavelike and particlelike behaviour with the quantized nature of light becoming apparent in the realm of quantum technologies the quatto network aims to merge the fields of quantum optics and quantum information science with attosecond physics this involves focusing on experimental campaigns to highlight quantum aspects in the interaction of intense laser fields with matter and advancing theoretical descriptions for a comprehensive understanding of the quantum state of light associated with intense laser fields traditionally attosecond pulses have been generated using tabletop femtosecond lasers however recent experiments performed at freeelectron lasers fels have demonstrated the production of isolated attosecond pulses and precise control of attosecond waveforms for pulse trains leading to remarkable advancements in attosecond science the network also aims to leverage recent advances in seeded fels and highintensity highharmonic generation hhgbased attosecond sources to demonstrate the coherent control of electronic dynamics in systems of increasing complexity the quatto network represents a comprehensive effort to advance the understanding and control of the interaction between electromagnetic radiation and matter with a specific focus on merging quantum optics quantum information science attosecond physics and freeelectron laser science the doctoral candidates dcs in the network will receive multifaceted scientific training encompassing experimental and theoretical aspects of quantum information science strongfield physics and soft xray and xray science as well as extensive training in transferable skills and selfmanagement techniques
cold organic chemistry

this proposal ventures into organic chemical reactions under notsocommon conditions namely in the cold at insufficient energies and under the action of hard radiation as many organic molecules have been discovered in space or brought to earth in meteorites they must have formed under such conditions through hitherto largely undisclosed mechanisms one key hypothesis is that quantummechanical tunneling qmt and novel reactions with exceptionally low barriers are at work hence one of the key objectives is to uncover how qmt where reactions occur through and not over barriers controls chemical reactivity and selectivity a second goal is the examination of cryogenic reactions of hydroxycarbenes or enols with carbonyl compounds our methods include organic synthesis of starting materials also isotopically labelled and products infrared as well as ultavioletvisible matrixisolation spectroscopy ab initio computations of structures spectra and potential energy surfaces as well as qmt rate calculations we will examine isotopeselective reactions of competing qmt reactions that can be made selective through strategic isotope incorporation qmt also offers new ways to activate carbon dioxide and even to catalyze reactions we propose a unifying synthesis of carbohydrates and alphaamino acids through a common mechanistic scenario namely a newly discovered heterocarbonylene reaction of carbenes or enols in the gas phase finally chemistry far from thermodynamic equilibrium is explored with probing the activation and reaction of highly stable molecules under irradiation with energetic electrons thereby mimicking conditions of the interstellar medium exposed to galactic cosmic rays this should shed light on the formation of larger complex organic molecules found in this medium and often considered as building blocks for life
animal abidings recovering from disasters in morethanhuman communities

what and how can we learn from animals about recovering from disasters how can we hear them in their own terms translate their stories and include their perspectives in human knowledge about disasters this project explores the resilience of multispecies communities and their capacities for healing and bouncing back from disasters through the point of view of nonhuman animals it departs from the current context of acute climate crisis which sets the stage for dantesque scenarios of impending climatedriven disasters such as wildfires floods tornados and hurricanes with related extensive loss of both human and nonhuman lives liveable dwellings and species extinction focusing on wildfires as disasters that challenge previous expert knowledge due to climate change and human exploitation of natural resources we propose to compare three countries where wildfires have taken on increasingly critical proportions every year brazil australia and portugal we address a species gap in our knowledge of disasters and wildfires in particular by exploring the possibilities of learning with animals how to live and cope with extreme change and uncertainty in wildfireprone areas drawing on contributions from sociologists anthropologists ethologists biologists and geographers abide aims at attuning to translating and including the voices stories and experiences of animals into our knowledge of how multispecies communities can better recover from the traumatic experience of wildfires in the end we seek to build the foundations for a new interdisciplinary framework for addressing humans and animals ability to build and abide in multispecies communities that are more resilient to wildfires and other disasters in so doing we aspire to identify the landmarks of a postspecies episteme and thus push forward the frontiers of knowledge of humananimal relations as well as contribute to a morethanhuman governance of disasters
releaf paper breakthrough technology for sustainable production of leavesbased fibre disrupting paper production and eco packaging industries

releaf paper is the first and the only producer of cellulose from fallen leaves in the world with a patent for the technology based on a unique method of combining mechanical chemical and thermal processes using standard equipment and a special drying procedure which allows obtaining a solid durable cellulose fibre for paper productionreleafs approach provides a solution of mass cutting trees for paper production and reduces co2 emissions by 78 in comparison with traditional paper productionreleafs paper production is sustainable at all stages of the production process 1sulphatesulphitefree reagents are used 2the process requires 15 times less water and 3 times less electricity 3paper products may be recycled up to 5 times without loss of quality or decomposed within 3060 daysthis solution is also costefficient due to the availability of raw materials and resourceefficient production thus the price for the consumer is lower in comparison with other alternatives
leaf heal the planets future

starting from the encouraging results of the leaf heal the planets future project in 2021 night edition we are now proposing a step forward to increase the awareness on the importance of research and innovation to improve trust in the researchers work by effectively involving the society in experimenting science through 600 events all activities will cover eu green deal topics farm to fork biodiversity circular economy zeropollution toxicfree environments health wellbeing energy and resource efficient buildings secure energy sustainable and smart mobility the main goal is to make science accessible and fun to everyone thus generating a practical understanding of how to cope with climate change issues the leaf project will be developed in 21 cities in italy involving 39 partners with a series of events happening during the last week of september 2022 and 2023 thus including the night leaf 2223 project will include a series of specific activities dedicated to schools to permit researchers to engage with teachers and pupils on challenges related to climate change sustainable development health and other issues related to the european commission priorities such as the european green deal in particular in this edition we will reinforce the experience at school through a dedicated work package on researchersschool involving institutes located in small towns with difficulties in reaching night events first year will be devoted to fulfill the achievements reached in last editions while in 2023 our main goal will be the improvement of project kpis thanks to the validation of the researchersschool activity the overall result will be a relevant increase in the awareness of why and how the researchers work is relevant for the benefit of our current and future planet as well as effectively encouraging young people in embarking in scientific careers by generating a real impact on science
sst networking security data sharing horizon europe top5

this horizon europe grant is to be understood within a wider context on eusst where other grants are being executed simultaneously with the common objective of improving the eu autonomy on space surveillance and trackingin particular this top focuses on support the upgrade development and security issues of eusst infrastructure based on the european network of assets sensors operation centres front desk the eusst infrastructure will remain under national control meaning mainly sensors and operation centres but increased coordination is needed due to the increased number of assets contributing to the european sst system sst networking of sensors operation centres eu sst network command control considering the increased number of objects to be handled an increased number of events and users is expected the european sst system has to evolve to a coordinated scheduling of the resources and assets ensuring that the events are covered in an optimum way while the current survey and tracking of the space objects population continues to be performed research on eusst network hardening against external threats the research concerns securitycritical aspects of the existing eu sst network next generation exchange protocols solutions for ssa enhancing interoperability and security robustness information assurance intrusion detectionthe starting point of these activities is the output of 23sst201820 which constitutes the state of the art on sst matters