Dragon09/odtu_chatbot huggingface dataset:
unmet uncovering mechanisms and establishing strategies to target vessel coopted colorectal cancer liver metastases

an estimated 2550 of colorectal cancer patients will encounter liver metastasis during their illness tumor vessel cooption is a nonangiogenic mechanism whereby tumors rather than forming new blood vessels a process known as angiogenic growth hijack preexisting blood vessels in the affected organ standard antiangiogenic therapy aat is ineffective against vessel cooptioned tumors this process has been linked to unfavorable patient outcomes the exact mechanisms distinguishing vessel cooption remain elusive preliminary data suggest that metastatic cancer displaying the vessel cooption phenotype increased in gene expression regulated by lymphoid enhancer binding factor 1 or lef1 protein which is a key mediator of the wntcatenin signaling the dysregulation of the wnt pathway can activate target genes that promote cell proliferation and survival in this proposal i hypothesize that inhibition of the wnt signaling eg by blocking lef1 will change the properties of vessel cooptioned tumors and improve the effectiveness of conventional treatment for liver metastases patientderived organoids obtained from hospitals will be used to validate whether the inhibition of lef1 will impact the vessel cooption phenotype making it more susceptible to aat advanced microscopy techniques like atomic force microscopy and scanning ionconductance microscopy will facilitate monitoring the decreased stiffness of vessel coopted tumor cells leading to improved aat delivery by using humanized patientderived organoid xenografts with inhibited wnt signaling i will monitor tumor growth its phenotype and the response to aat in vivo furthermore i aim to pinpoint diagnostic markers for vessel cooption tumors using blood tests and computed tomography ct scans utilizing artificial intelligence tools i plan to analyze ct scans of liver patients to better predict metastatic tumor subtypes and treatment responses in the future
metamaterials for laminar flow control on a wing

achieving extensive laminar flow can reduce aircraft drag by up to 15 offering breakthrough potential for curbing polluting emissions in aviation and other energyintensive sectors to achieve this wavelike flow instabilities growing in laminar boundary layers need to be controlled and attenuated to delay transition from laminar to turbulent flow however their complex multiscale and broadband nature makes these instabilities extremely challenging to controlin metawing i propose a new disruptive concept for flow control first born in classical wave physics metamaterials these are engineered composite structures invoking dispersive wave phenomena to gain exotic properties that go beyond what is considered possible in nature the main such property i want to explore is the bandgap a range in which waves are suppressed when interacting with the metamaterial my team and i have recently found key evidence of dispersive wave suppression in boundary layers however wavelike flow instabilities have key differences from classical waves forming a new regime of dispersive wave interactions thus the nature of bandgaps in boundary layer flows remains unclear and unexplored i aim to reveal and understand the formation of bandgaps in transitional fluid flows and use them to suppress wavelike boundary layer instabilities thus delaying laminarturbulent transition to achieve this i propose the first holistic intersection of metamaterials and laminar flow control using theory numerical simulations novel fabrication methods and stateofart experimental measurements the combined results will uncover the complex dynamic behaviour of flow instabilities under dispersive interaction with metamaterials and will help us understand and fully exploit bandgap mechanisms in transitional flows metawing will create a new class of metamaterials for flow control and pave the way to ultralow drag wings for the next generation of emissionfree aviation
ontological diversity in environmental education

working as an environmental education ee facilitator i can attest to the fact that a feeling of urgency detachment helplessness and lack of alternatives tends to be a common reaction when working with ee in the european context this has led me to question the factors that influence the learning process within ee building on my past work on ideological and epistemological blockages to effective social change this project will utilize the concept of ontology as a more encompassing term for social analysis based on analytical frameworks on secularism religion and climate change developed within the faculty of theology and religious studies at groningen university together with transdisciplinary currents of thought such as political ontology and agroecology in the proposed research i will study the role of ontological diversity in environmental education ee utilizing concepts and methods from the field of theology and religious studies trs framing the research within trs will allow us to find a critical perspective on the dominant secularscientific tradition behind ee policy and implementation as well as the presumed secularitybased ontological homogeneity of ee in western and westernized contexts in this research we will explore if the effectiveness of european environmental education is being hindered by lack of ontological diversity together with ways in which trs can contribute to fostering ontological diversity od within ee i will be focusing on ee in the contexts of barcelona spain and havana cuba using literature review expert interviews critical discourse analysis grounded theory good practice analysis and participatory actionresearch par in order to develop four scientific articles on od in ee a handbook for ee practitioners a handbook for policy makers and policy recommendations for eu greencomp implementation
streamlining the optimisation of sustainable thermal energy systems and prototype technologies in process industries

european process industries face significant challenges in a changing geopolitical landscape under the threat of climate change and against fierce international competition in this context boosting the resilience and competitiveness of process industries while taking surefooted steps towards climate neutrality is of existential importance streamstep is the vision of 31 organisations across eu switzerland norway and uk aspiring to trigger significant improvements of how heating energy is managed within industrial processes the project will address processes that generate waste heat across all temperature grades from 135oc to over 1400oc deploying five innovative heat exchanger prototypes for challenging applications and achieving flexible operation across multiple heat sinks heat upgrade will be managed through high temperature heat pumps achieving outlet temperatures at 150oc and at 215oc with improved performance through ejector technology and the capacity to operate dynamically across a range of required temperatures enablers of these innovations are advanced manufacturing techniques achieving superior material performance through novel material alloys the system will be demonstrated across five sectors nonferrous metals ceramics minerals plastics and refining the demonstrators will be supported by impact boosting resources derisking the investment and accelerating commercialisationa holistic process digital twinning pipeline will be integral to these advancements as it will provide the infrastructure to deploy powerful optimisation agents addressing energy balance intermediary storage ghg avoidance and datadriven lcathe effects of the streamstep project will be significant as the recovery and efficient reutilisation of the majority of waste heat 50over 90 will be achieved with systems boasting a payback below 3 years with the added effects of increasing productivity in selected processes as well as energy flexibility
hydrogen demonstrator for aviation

the hydea project which stands for hydrogen demonstrator for aviation proposes a robust technology maturation plan to develop an h2c hydrogen combustion propulsion system compatible with an entry into service of a zeroco2 lowemission aircraft in 2035 consistently with the expected timeframe of the european green deal and ca sria objectives the project aims to address fundamental questions related to the use of hydrogen as an aviation fuel concentrating on the development and testing in relevant conditions of an h2 combustor and h2 fuel system also including emission studies and further technologies which will serve as an outlook to future engines ie nox optimization studies potential contrails emissions and investigating integration aspects between engine and aircraft hydea results will be core for the zeroe technology exploration project launched by airbus in 2020 the revolutionary technologies in scope call for an early engagement and dialogue with easa european union aviation safety agency within hydea starting from phase 1
nmr relaxation tools for improving and protecting quality of dairy products

nmrimprov proposes a radically new approach to investigating properties of dairy products by exploiting nuclear magnetic resonance nmr relaxation including fast field cycling and timedomain nmr methods the core of the concept is to acknowledge that macroscopic properties of dairy products are largely determined by dynamics of individual molecular fractions from macromolecules to water present in the system revealing and understanding the dynamics and arrangement of molecular fractions consisting dairy products is essential for providing a foremost guideline for designing products of required rheological properties and texture avoiding effects such as aggregation or phase separation and assessing authenticity of the products the goal of nmrimprov is to form an interdisciplinary and intersectoral network including physicists chemists mathematicians food scientists and engineers and software and electronic engineers to develop nmr relaxation based means to gain knowledge on dynamical properties of dairy products on the molecular level relationships between nmr relaxation parameters and macroscopic properties of dairy products investigated by conventional methods will be established the knowledge is meant to be exploited to address challenges of dairy technology associated with development and storage of products that are fermented plantbased personalized and manufactured from local raw goods moreover nmrimprov aims at establishing nmr relaxation as a tool for evaluating quality and authenticity of dairy products nmrimprov builds a bridge between specialists from academia with deep expertise in nmr relaxation and food scientists and engineers for the ultimate goal of transferring nmr relaxation from academia to dairy industry this is to be achieved by profiting from the synergy and transfer of knowledge between the parties involved and intensive training of young researchers and industry members
adaptive virtualization for aienabled cloudedge continuum

as of today 80 of the data processing and analysis occurs in cloud data centers and only 20 of processing occurs at the edge this incipient exploitation of edge resources increases time to value and prevents business processes decisions and intelligence to be taken outside of the data center which prevents europe to unlock an entire set of new opportunities to serve different industries and use cases in europe in the next years to help to materialize the european bid on a true continuum in the next few years cloudskin pursues to build a cognitive cloud continuum platform with three main innovations 1 the cloudskin platform will leverage aiml to optimize workloads resources energy and network traffic for a rapid adaptation to changes in application behavior and data variability reconfiguraing the sweet spot between the cloud and the edge in the face of the rapid varying conditions
improving crop productivity by relieving the inhibitory effect imposed on photosynthesis by the redox regulatory network

while the global demand for crop production is constantly increasing and a significant increase in agricultural yields is required we have witnessed stagnation in yield improvement of major crops hence there is an urgent need for new strategies to ensure food security in a sustainable manner it is becoming appreciated that improving photosynthetic efficiency is one of the most important ways to increase yield while the dependence of photosynthesis on the reductive activation of the calvinbenson cycle enzymes is well established the role of oxidative signals in counterbalancing the reductive activity is just beginning to be explored by developing genetically encoded 2cys peroxiredoxinbased biosensors we identified the simultaneous activation of reductive and oxidative signals during the photosynthesis induction phase and showed that 2cys peroxiredoxin activity attenuates carbon assimilation rates these results demonstrated the restrictions imposed on photosynthesis performance by oxidative signals thus laying the foundation for developing new approaches for increasing photosynthesis efficiency through redox modulations the central goal of this proposal is to extend our mechanistic understanding of oxidative signal generation and perception and to develop new strategies to improve photosynthesis in crop plants by relieving the inhibitory effect of oxidative signals under fluctuating light conditions we suggest applying advanced redox biology methodologies to discover the molecular components involved in regulating the oxidative pathway and to decipher the oxidationsensitive proteome moreover we suggest translating the gained knowledge into technologies that improve photosynthesis in potato plants one of the worlds most important crops this project aims to provide the necessary knowledge to enhance photosynthesis through redox modification in crops and to produce new potato lines with higher productivity and adaptability to modern agriculture
batteries reuse and direct production of high performances cathodic and anodic materials and other raw materials from batteries recycling using low cost and environmentally friendly technologies

rhinoceros will develop improve and demonstrate in an industrially relevant environment an economically and environmentally viable route for reusing repurposing reconditioning and recycling of eol ev and stationary batteries rhinoceros will first develop a smart sorting and dismantling system enabling the automated classification and dismantling of libs and the reassembly of still working modules in new repurposed batteries for second life applications such as batteries for energy storage systems when direct reuse and repurpose of batteries is not possible a circular recycling route of all the materials present in libs eg metals graphite fluorinated compounds and polymers active materials will be followed to close the materials loop this route is based on a set of cost efficient flexible and environmentally friendly routes targeting the pretreatment refining and the recovery of materials through product qualification by industrial endusers rhinoceros will demonstrate the direct production of high performances cathodic and anodic materials and other raw materials at competitive costs from battery recycling the achievements will bring europe to an increased independence level from foreigner manufacturers and raw materials suppliers
an environmentalfriendly alternative to recovery rare earth elements from spent ndfeb permanent magnets by electrochemical recycling process

the european union eu has the ambitious target to reach net zero greenhouse gas emissions by 2050 the current energy transition is playing a crucial role in achieving a greener future by electrification of industries and the use of renewable resources for energy many greener applications rely on electric motors or generators that contain ndfeb permanent magnets pm in large quantities the composition of these magnets is about 30 of rareearth elements rees mainly neodymium nd the worldwide supply of rees is controlled by china 85 as the demand of rees is increasing due to energy transition it is important for the eu to ensure a continuous supply of rees recycling endoflife magnets is a feasible alternative to obtain rees from secondary resources with reecycle research project my objective is to determine for the first time the leaching mechanism of rees in ndfeb magnet scrap aiming at selective recovery of rees by means of electrochemical leaching in organic acids i will combine different electrochemical approaches at different scales to evaluate the electroleaching efficiency in organic acids aiming at the selection of the most suitable acid and process conditions for a high dissolution rate of rees then to determine the leaching mechanism under electrochemical effect i will use a recently developed local electrochemical technique scanning electrochemical cell microscopy seccm which will indicate the dissolution parameters for each element present in the ndfeb matrix finally with the findings from seccm i will be able to promote a controlled electroleaching in organic acid followed by oxidation of fe2 to selectively recover the rees from the magnet scrap with my project the use of organic acids and an electrochemical approach will bring the realisation of a sustainable recycling of permanent magnets a step forward thereby contributing to the eus knowledge in ree supply from secondary sources
high voltage room temperature singleion polymer electrolyte for safer all solid state lithium metal batteries

the greatest challenges towards the worldwide success of batterypowered electric vehicles revolve around the safety energy density and cost of the battery technologies solidstate polymer electrolytes and lithium metal anode address these challenges by replacing the flammable and unstable liquid electrolytes and enabling dendritefree cycling of highenergy lithium metal cells manufactured by sustainable and costeffective processing the psionic project advances the development of allsolidstate battery technology by employing amorphous crosslinked polyethylene oxide peo laminated on the thin lithium foil at the anode and high voltage cathode coated with a singleion conductive polymer this will allow to replace the flammable and unstable liquid electrolytes and enabling dendritefree cycling of highenergy lithium metal cells manufactured by sustainable processing special attention will be devoted to the optimization of interfaces between the active material and polymer electrolyte materials selection will enable the use of the manufacturing technology available at bluesolutions which is readily scalable based on sustainable processing using solventfree extrusion psionic is aiming to develop cells with a safety hazard level 2 since no liquid component will be in the cell at the end of the project the research and innovation actions carried under the psionic project will not only just contribute to the technological advancements of allsolidstate liion batteries in terms of safety reliability performance cost and sustainability but will also enable higher uptake by the electromobility sector and end consumers paving a pathway towards climate neutrality and green energy transition
seamless integration of efficient 6g wireless technologies for communication and sensing

6gsenses proposes the integration of novel 6g ran technologies such as cellfree cf massive multipleinput multipleoutput mimo and joint communication and sensing jcas to support the 6g vision that is sustained by the current and future architectural framework based on 3gpp and oran the project considers a multitechnology ran ecosystem with technologies that are able to offer sensing functionalities these technologies are sub6 wifi millimeter wave and 5g nr which will coexist in a jcas framework whose goal is to retrieve as much information as possible from the surrounding environment to improve energy efficiency reduce power consumption and favour communication at high data rates additionally some of these technologies will be amenable to be integrated in the first implementation of a fully distributed cfmmimo scheme using mmwave and sub6 technologies with the aim to enhance availability and coverage and to improve sensing performance will leverage reconfigurable intelligent surfaces riss making use of the distributed nature of the access points and availability of multiple antennas an optimization of distributed signal processing and resource allocation schemes tailored for risassisted cf network architecture is proposed this framework will make use of new phy technologies to increase the cooperation among access points and their inherent capabilities to improve the precisionaccuracy of the sensing capabilities sensing information stemming from these technologies will be pushed to the oran framweork for optimization purposes using the radio intelligent controllers rics a total of three proofofconcept demonstrations will be showcased which encompass the proposed objectives of the project in a single infrastructure
dependency of future climate projections on south atlantic heat and salt transport modulated by interocean exchanges

the atlantic meridional overturning circulation amoc is a complex system of upper and deep ocean currents that redistributes heat between the southern and northern hemisphere changes in the amoc modulate european and global climate and represent a key uncertainty for future climate projections over the last decades climate scientists have related changes in the amoc mainly to oceanic changes in the northern hemisphere though there is increasing evidence for additional southern hemisphere origins conceptual studies with numerical ocean models and paleoclimate records suggest that changes in the south atlantic heat and salt transport due to altered exchange processes with the indian and pacific ocean can impact the strength and stability of the amoc however it is unclear how these processes are represented in current climate modelsthe overall goal of climsate is to unravel how future climate projections depend on the simulated heat and salt transports in the south atlantic with a focus on the role of interocean exchange processes to achieve this i will develop an advanced framework for analyzing the simulated south atlantic heat and salt transports based on virtual particle tracking methods and then apply it to a representative ensemble of stateoftheart climate models i will elucidate the processes that determine the mean heat and salt transport in the south atlantic and their changes under anthropogenic climate change and how the heat and salt transport changes in the south atlantic are linked to the strength of amoc the project results will improve future climate assessments and hence directly contribute to the adaptation to climate change mission of horizon europe the training activities eg in software development and targeted career development measures will allow me to consolidate my research profile and skill set in view of my ambition to become an independent and impactful research leader