Dragon09/odtu_chatbot huggingface dataset:
additive manufacturing of molecularlevelengineered sicn ceramic modified with carbon nanofiberstransition metal carbides towards nextgeneration structural electromagnetic metamaterials

ceramicbased hightemperature structural electromagnetic absorption materials emams is playing an increasingly important role in combating the em pollution however ceramicbased emams always suffer from poor mechanical strength due to the intrinsic high brittleness and unsatisfactory em performance limited by the material characteristic as well as the monotonous loss mechanism of absorbents in this project advanced sicn matrix modified with one dimensional 1d carbon nanofibers2d transition metal carbides eg tic vc and mo2c cnfstmcssicn ceramicbased structural em metamaterials will be innovatively developed by combining molecularlevelengineered polymer derived ceramic pdc and additive manufacturing am techniques novel 2d tic vc and mo2c nanoabsorbentsreinforcements will be developed via a precursorderived method outstanding em performance is expected to be realized by the establishment of multiloss mechanisms ie interface defectinduced and dipole polarization loss and conductive loss via nanomicrostructure engineering of cnfstmc absorbents and realization of novel metastructures using am improved mechanical strength will be achieved by strengthening of the sicn matrix by cnfstmcs the main idea of the present proposal is to merge material type and nanomicrostructure innovation of absorbentsreinforcements as well as metastructure innovation of materials to innovatively develop the cnfstmcssicn structural em metamaterials as the next generation hightemperature structural emams the general relationship between nano and microstructure macrostructure by design and loss mechanisms em and mechanical properties will be revealed this project will pave new avenue for the development of next generation emams
next generation integrated floating wind optimized for deep waters

nextfloat aims at reducing the lcoe and increase the competitiveness of floating offshore wind fow to accelerate largescale deployment the project will demonstrate an integrated system composed of x1s lightweight floating platform with its proprietary pivotbuoy connection system a novel design for offshore wind platforms that optimizes the structural design reduces weight of the structure and greatly improves mooring and installation techniques and costs and 2bes 2bladed downwind turbine an advanced rotor that requires less material fewer components reduced capital and operational costs and improved environmental benefits the project also proposes innovations to bring costefficiency improvements to the dynamic cable by using aluminium as a conductor material this innovative concept will be demonstrated in mistral site in the mediterranean seathe design of a 14mw fully integrated system will be developed with a strong focus on optimizing the technological solutions for deep waters and making it suitable for different eu offshore sites in parallel this design will take into account mass production and largescale deployment as key elements to make floating offshore wind a competitive renewable energy source the project will develop an industrialization roadmap for this fow concept in order to facilitate the mass productionfinally nextfloat will define a commercial plan for future largescale deployment that integrates crosscutting aspects to ensure a sustainable replication based on the analysis of costs life cycle assessment and socioeconomic factors
waves in the inner magnetosphere and their effects on radiation belt electrons

the magnetosphere is a natural plasma laboratory radiation belts in the magnetosphere are full of high energy particles the energetic electrons in the earths radiation belts can be hazardous to earthorbiting satellites and astronauts in space many of the space systems on which modern human society depends operate in this region the fluxes of radiation belt electrons are very dynamic which is not fully understood due to the delicate balance between various acceleration and loss processes waveparticle interactions are believed to play a crucial role in the acceleration and loss of these particles to quantify the effect of different waves on the dynamics of radiation belt electrons comprehensive wave models are needed currently there are some wave models based on satellite measurements however the space coverage of these wave models is not sufficient due to the orbit limit of satellites in this project combining stateoftheart measurements from multiple satellites comprehensive wave models will be developed we will improve our sophisticated physicsbased radiation belt dynamic model by using the wave models developed in this project and calculate diffusion coefficients using more realistic background magnetic field and plasma density models for the first time furthermore fundamental acceleration and loss of energetic electrons caused by different waves in the earths radiation belts will be quantified we will systematically validate simulation results against satellite measurements to understand the competition between acceleration and loss caused by various mechanisms all these improvements will be critically important for answering the overarching scientific question why do the earths radiation belts respond differently to geomagnetic storms which have approximately the same intensity the knowledge gained in this project can be useful for basics plasma physics and astronomy physics because the similar fundamental processes exist
bestinclass cancer diagnostic chip for patient stratification

through advanced microengineering and nanotechnology we have developed a proprietary microfluidicbased liquid biopsy device the rubychip pctep2016078406 this technology allows for the isolation of all types of ctcs keeping them viable and enabling the analysis of their phenotypic genetic and functional characteristics enabling unprecedented frequent monitoring of cancer progression in a minimally invasive and costefficient way our chip isolates 70 of the very scarce ctcs from a 75ml blood sample of a cancer patient in less than 3 h and without the need of sample preprocessing this dramatic improvement in the sensitivity compared to competition is enabled by a unique microfilter network embedded in a microfluidic device that separates the ctcs from the healthy cells based on their size and deformability furthermore the rubychip enables automation reducing interlaboratory and interuser dependence and ensuring reproducible analysis of ctcs
comparative physiology of adaptation to coldextremes in boreal ants

the acquisition of coldtolerance is one of the most ecologically relevant processes for ectotherms inhabiting temperate and boreal climates given the fundamental importance of coldadaptation in shaping ectothermic species distribution much effort has been put into deciphering the physiological mechanisms constraining the plasticity of their coldtolerance however we still know little about how evolutionary pressures have shaped coldtolerance acquisition in some key and ecologically relevant models for colderecosystems such as ants ants are among the most represented and abundant insects in temperate and boreal climates providing unprecedented amounts of ecosystem services by their sheer biomass some higherlatitude species further display the striking ability to survive prolonged exposure to temperatures of 40c yet to this day we still lack a clear and comprehensive understanding of the molecular mechanisms supporting this impressive feat considering this central gap in our knowledge we propose here to explore the molecularlevel mechanisms associated with the temporal acquisition of coldtolerance in ants inside a consistent study system made of groups of boreal temperate and mediterranean closely related species using this phylogenetic framework we will i compare species potential for coldhardiness and link coldtolerance acquisition with the ii genetic response and iii metabolomic reorganization in models overall this project proposes to explore important yet unanswered aspects of insect cryobiology that are located at the frontier of our current understanding of ecophysiology it will explore the comparative physiology of coldacclimation in boreal ants allow for the potential discovery of novel coldtolerance mechanisms in insects and ultimately feed data into our integrated understanding of how from gene to organisms the acquisition of coldtolerance has shaped the success of insect life in colder environments
connecting greek and portuguese innovation ecosystems to develop a hub for infectious diseases diagnostic solutions at the pointof care tackling crossborder threats

the aim of dxhub is to develop a strong ecosystem that mutually reinforces actors from two widening countries to consolidate individual efforts and allow for rapid and on the spot accurate diagnosis of infectious diseases within onehealth the ecosystems in crete gr and the oeiras region pt have already demonstrated a rich portfolio of activities to tackle the problem of efficient diagnosis outside a centralized lab the dxhub will bring the two isolated regions together and through a common ri plan accelerate innovations in diagnostics into impactful solutions by embracing the quadruple helix of main innovation players cuttingedge ris will be promoted based on joint research innovation and investment plans pilot projects will be used to interlink academia with business providing solutions addressing the health veterinary and agrifood sectors all in line with both regions strategic priorities in parallel the efficient communication dissemination and exploitation of the dxhub outcomes to the broad ecosystem will ensure high societal impact as a result of the codevelopment and acceptance of the new innovations by all actors of the quadruple helix we expect that by building strong links between all payers of dxhub will foster knowledge transfer leading to the creation of new jobs and of attractive and sustainable placebased innovation ecosystems
importance of human and endothelial cell cooperation for the maturation organisation and functionality of islet organoids

to cure diabetes functional cell mass must be restored transplantation of human islets has seen significant progress over the past decades however organ donor shortage is a major obstacle for transplanted patients poor graft revascularisation and a recurrent autoimmune attack ultimately result in the loss of the graft human induced pluripotent stem cell ipscderived cells are a promising alternative source of cells that is inexhaustible and allows genetic interventions prior to transplantation to stimulate revascularisation immunoprotection and ultimately graft survival ipsc cells retain an immature phenotype in vitro and only in vivo acquire mature function equivalent to that of native human islets intraislet endothelial cells ecs form a necessary niche for pancreatic endocrinogenesis and adult cell function and they improve islet survival after transplantation this proposal aims to test the hypothesis that ecs are crucial to generate mature and functional human ipscderived islet organoids in vitro and to promote revascularisation function adaptation to metabolic challenges and survival in vivo to this end we will generate vascularised islet organoids containing ipscderived endocrine and ecs by combining genetic interventions and cuttingedge technologies such as whole tissue threedimensional analysis and transcriptomics we will characterise the impact of ecs on islet organoids this project will broaden the knowledge on the essential relationship linking structure to function in human islet organoids paving the way for new human cell therapies
microbial soil colonization and structure formation by fungal hyphae mediated transport

microbes in soil drive ecosystem services defining life on the earth translocation of these microbes is key features in the spatial exploration of soil this directly impacts major ecological processes such as niche colonization and the development of soil structure but knowledge of how microbes migrate in soil is scarce a potential universal mechanism is fungal hyphae mediated transport fhmt where bacteria use hyphae of fungi as a route to translocate in a directed manner however this has been solely observed in the laboratory but not in soil where singlecell level studies are restricted by technical limits micolfuntrans overcomes these limitations by developing and exploiting a novel system combining microfluidics microbiological and microscopical methods to i observe microbial movement in soillike systems and ii identify single involved organisms microchannels will provide treatments to compare soil colonization and structure formation with and without fhmt ultimately findings will be upscaled to an ecological level in a dedicated field study using a glacier forefield in the arctic which constitutes a unique natural laboratory to study initial soil development as ongoing climate change melts glaciers and frees vast areas of barren soil at present the results of this project will foster an integrated view on the soil biome and push research on bacterialfungal interactions to the centre of attention in soil microbiology and related industries specifically knowledge of migration rates of microbes in soil will impact models on nutrient distribution and efforts in bioremediation of contaminated soil a better understanding of the initial stages of soil structure formation at the microscale will impact efforts in soil quality and health preservation related actions a topic of highest societal and economic interest as the degradation of soil is one of the most pressing environmental threads we are currently facing
dendritic activity and neuromodulators in active learning

neuroscience research tries to tease apart how brain circuits work together to give rise to behaviour namely cognitive flexible processes such as reinforcement learning rl rl requires neurons to be tuned to relevant inputs in order to maximize behavioural performance most of the excitatory synaptic inputs in pyramidal neurons are located in the thin dendrites where the majority of the spines are located thus thin dendrites play a crucial role in synaptic integration and experiencedependent plasticity they mediate local computations that endow single neurons with a variety of inputoutput transformations and change their information transfer in agreement individual dendrites have been proposed as the fundamental computational unit of neurons and the substrate for increasing the computational power of the brain on the other hand the neuromodulatory systems are known to be critical regulators of brain states and of adaptive responses relevant to rl different neuromodulators acting through their receptors can alter intrinsic properties of dendritic ion channels and receptors and synaptic efficacy having a direct impact on dendritic computations thus in order to understand how the brain allows to quickly improve behavioural performance during rl it is critical that we 1 gain insight about the activity on thin dendrites 2 to systematically understand the activity of different neuromodulatory inputs on those and 3 their impact on rl this proposal aims at identifying how neurons change their properties during rl by observing and manipulating the neurophysiology of behaving mice using interdisciplinary approaches and stateoftheart methods the work will address several original questions 1 what is the role of tuft dendritic activity to implement an adequate rl 2 what is the role of different neuromodulators in shaping the tuft dendritic activity and on rl
hunting ghost neurons in the neuroendocrine hypothalamus

the hypothalamus contains heterogeneous neurons that dictate behaviours and physiological functions through crosstalk mechanisms with peripheral hormones neuronal diversity is the key to enabling hypothalamic functions and according to the neuroscience dogma is mainly preset during embryonic life but what if this model is incorrect can neuronal heterogeneity be plastically modulated throughout adult life as well here based on my published work and solid preliminary results i propose that special ghost neurons in the hypothalamus display plastic mechanisms of cellidentity reprogramming to accommodate neuroendocrine functions in adult life under physiological conditions such identity plasticity can become maladaptive and contribute to neuroendocrine disorders such as obesity my central hypothesis is that atypical ghost neurons are hidden within mature populations of neuroendocrine brain neurons the ghostbuster project will hunt down these brain cells and uncover their role in physiology and metabolic disease a multidisciplinary approach will be used toward this goal uniting lineage tracing strategies nutritional interventions singlecell profiling of hypothalamic neurons bioinformatic analyses and viralbased tools for targeting ghost cellrelated genes these strategies will be combined with behavioural metabolic and hormonal assessments of mice models of ghost neuron loss or gain of function the project will overturn the dogma that postmitotic neurons have negligible cellreprogramming capacity and revolutionise our understanding of how brain functions are plastically regulated throughout life we will shed light on key molecular targets that allow the reprogramming of neuronal functional identity for therapeutic use and provide a novel framework for understanding the fundamental biological mechanisms that cause neuroendocrine disorders such as obesity infertility and beyond
encouraging farmers towards sustainable farming systems through policy and business strategies

enfasys aims to stimulate a just and robust transition to sustainable productive climateneutral biodiversity friendly and resilient farming systems sfs by improved policies and business strategies that encourage farmers to change their production systems in current food systems farmers are challenged by multiple lockins that prevent them to move to sfs to overcome this and thus to support the green deal and in particular the farm to fork ambitions strengthening public strategies policies should go hand in hand with strengthening private strategies business models social innovations to reach this aim enfasys goals are 1 an improved understanding of lockins and levers in farming and food systems2 an improved understanding of behavioural factors of farmers consumers and other food chain actors3 more and better evidence on the potential effectiveness of interventions4 a more structured approach to link knowledge to action to do so enfasys will frame current transitions to sfs and screen 160 cases for current interventions through systems analysis behavioural and experimental studies enfasys will uncover lockins from a systemic and behavioural point of view the potential of policy and business interventions will be tested in 1215 countries across europe through experimental studies discrete choice experiments framed field experiments and randomized trials and system dynamic modelling to link systemic and behavioural insights to action and to understand the impact of the interventions on systems level results of these studies will be combined into system and behavioural based theories of change together with stakeholders and enriched by the research results enfasys will codesign policy mixes business strategies and social innovations and stimulate their implementation strategic communication dissemination exploitation and tailored capacity building towards all our target groups will maximize enfasys impact
agile and flexible construction materials standardization for boosting the twin transition

over the past decades european standards have delivered great benefits for companies and consumers on the single market in the light of the social and environmental ambitions of the new growth strategy the eu green deal and the twin transition europes competitiveness technological sovereignty and ability to reduce dependencies will directly depend on how successful european actors are in standardisation at international level the eu standardization strategy from 2022 calls for more flexible and focused approach to standardization processes which can respond to the fast pace of twin transition innovating the agile and flexible construction materials standardization for boosting the twin transition afcos project aims to set up recommendations for more agile standardization processes for construction materials based on prenormative research performed horizontally in a collaborative fashion between key ecosystem players research standardization and industrial actors from four member states bulgaria romania italy and belgium afcos will focus on identified standardization urgencies within the industrial ecosystem of construction and more specifically on standards supporting low carbon cement building on a set of activities combining research work with stakeholder engagement educational activities and ambitious exploitation initiatives afcos will produce roadmaps for prestandardization educational and training courses strategy for education and skills development in the field of standardization of new building materials and exploitation models for the benefit of the european standardization organizations esos national standardization bodies educational institutions and industryafcos brings together 7 full and 5 associated partners from 9 eu countries encompassing research capacity standardization expertise and industry representation and ecosystem actors ensuring eu coverage and exploitability of the project results to a high level
evaluating and programming intelligent chatbots for any language

intelligent chatbots ics such as chatgpt have revolutionized the generation of content for a few languages such as english but there are 7099 currently spoken languages in the world epical will for the first time determine how to add new low resource languages lrls to ics we will make six advances to revolutionize the capabilities of ics unifying different areas of research that are incorrectly studied separately we will 1 determine how to generate hallucinationfree text using ics and how to enter a virtuous cycle where lrl text is created using crosslingual knowledge from ics and then quickly postedited and trained upon resulting in a better lrl representation in the ic 2 develop more powerful encoding and language adaptation approaches which combine the benefits of finetuning and adapters taking full advantage of linguistically related languages to model lrls 3 enable ics to reason about their own lrl capabilities and determine what they know and do not know 4 unify research on machine translation and ics to obtain ics which can translate to lrls with stateoftheart accuracy 5 enable high quality texttospeech and automatic speech recognition of lrls with ics thereby unifying the research on low resource speech processing with research on lrl text processing 6 develop a novel evaluation methodology including a robust method for automatically measuring fact hallucination my research group is wellknown for lrl research which differs from large commercial labs focusing only on the top 200 languages our work is critical for a multilingual europe which values the role of minority languages culture and heritage our innovations will benefit natural language processing beyond text generation and machine translation and strongly impact other areas of machine learning research suffering from data bottlenecks