Dragon09/odtu_chatbot huggingface dataset:
development of a scalable respiratory diagnostic platform

chronic respiratory diseases affect 10 of people and are the third cause of death worldwide they cause significant disability and social exclusion a key problem is the large under and misdiagnosis of such diseases late diagnosis of the diseases leads to lack of treatment and a rapid decline of the disease causing severe exacerbation frequent hospitalization and high mortality with huge costs to the healthcare systemsthrough design thinking and lean methodology we discovered a market opportunity the current tools in primary care are not suited for nonspecialists to tackle lung disease diagnosis they require difficult breathing procedures from the patients leading to inaccurate tests and incorrect diagnosis it also creates mistrust in the technologies leading to underdiagnosis through lack of testingour solution is a quick easy and accurate tool that doesnt require patient effort it can be used in any clinical setting but is particularly suited for nonspecialists in primary care for disease diagnosis and monitoring the output is trained on the lung experts decisions providing a diagnostic support tool for quick and effective decisionmaking where it is needed most early diagnosis and followup allows clinicians to intervene and educate the patient when treatment can still have a positive effect on their lung function and reduces the huge burden to the healthcare system due to avoidance of the severe stages of the disease saving an estimated 5 bn in the eu from hospitalizations alonethe womentecheu program provides the unique opportunity to test our technology in the clinical setting to reach a trl56 from current trl4 and protect our intellectual property it also means we can strengthen our gender and diversity hiring processes and develop our leadership skills the project achieves a major milestone and creates the required evidence to add significant value to our company and attract private seed investment to move us closer to market
photoredox catalytic metathesis of ttsalts and aryl bromidechloride via multicatalysis

sulfonium salts emerge as unique synthetic intermediates in recent years versatile exciting transformations have been developed since the breakthrough works by procters and ritters group progress made within just 4 years since thesee seminal works showcased their broad utilities surpassing that of organic halides depending on the conditions sulfonium salts engaged in various types of transformations such as suzuki coupling sonogashira coupling negishi coupling heck reaction carbonylation boronation chlorination iodination cyanation photocatalysis etc and realize the constructions of various cc cn co cx and cs bonds therefore they are considered skeleton key in late state functionalization thanks to excellent compatibility however compared with organic halides that widely exist in nature and are commercially available the synthetic methods for thiananthenium salts are still very limited currently the direct ch activation is the rare method showing efficiency for constructing aryl thianthranium salts although this synthetic method showed a remarkable advantage in exquisite remote regioselectivity it also uncovered a challenge in making other sulfonium salts with other substitution patterns impossibly such as on ortho and metapositions herein i propose to explore the potential of preparing synthetically omnipotent diversative aryl thianthranium tt salts from available aryl halides via functional group metathesis attractively the method will overcome the current limitation to the paraderivatives of ttsalts giving access to any substitution pattern of ttsalts ortho meta para bissubstituted etc the target ttsalts will open up a vast realm of transformations and construction of useful skeletons in fine chemical synthesis and development
development and clinical evaluation of an endtoend heart failure management solution powered by predictive ai

heart failure is a serious chronic medical condition that impairs the hearts ability to effectively pump blood globally it has a prevalence of 64 million people heart failure patients often have to be hospitalised to manage symptoms exacerbation these hospitalisations are preventable with databased insights and tailored therapies but no holistic data platform for heart failure patients exists todayimplicity is set to change this situation with its suite of datadriven insights for managing heart failure implicity already provides a heart failure remote monitoring platform with symptomsbased decompensation detection features in this project we are developing a second module that focuses on aibased prediction of heart failure events based on cardiac implantable electronic devices data combined with an endtoend software suite managing alerts treatments patient engagement and workflow optimisation enabling better care and decreasing the hospitalisation burden
eit food business plan 20232025

our business plan drives deep systemic transformational impact through innovation to tackle key challenges facing the agrifood sector today through four priorities missionsdriven approach aligning with our three missions our plan directly addresses the complex and critical challenges of sustainability and climate change noncommunicable diseases and poor nutrition and consumer trust scarcity and transparency designing for impact our calls seek out innovations with the most potential for systemic change through our new partnership and community we will bring together unique consortia who can accelerate innovation speedingup and scalingup solutions to market transforming our partnership around purpose our transformed partnership will have a depth of strategic expertise a core of delivery capability which will consistently bring innovation to market and a broad community providing insight energy and ideas marketready innovation we will create an ecosystem to accelerate marketready innovation leveraging the pillars of knowledge triangle integration innovation education and business creation catalysed by public engagement to create the foundations for the plan over the next three years we will deliver a wealth of innovations to market trained students new startups and deep engagement with the people who are part of the whole food value chain from farm to fork we will make a material difference to halys by enabling more consumers to make better choices through access to healthier products and actionable information we will be closer to a net zero food system reducing co2 equivalent emissions by tackling co2 hotspots reducing the footprint of proteins through diversification and creating new markets for food waste and we will see the benefits of more resilient trusted food supply chains with people experiencing greater food security and safety through widespread digitally enabled food supply chains
capacitation of a portuguese ri centre of excellence for plant pathogens detection and control

biomehealth aims to strengthen european and portuguese ri on agrofood systems that face climate change and newrecurrent pathogens with the support of wageningen univ research wur nl and bologna univ unibo itglobal trade and climate change favor the establishment of new pathogens in europe portugal needs to boost ri and educationtraining to empower a new generation of researchers in this field biomehealth has two ri objectives and four capacitation objectives aligned with the twinning call wur precision pathogens detection and unibo vocbiosensors biological control agents and syncoms will develop ri and capacitation of the widening partner requimteup that leads the national research in agrifood this capacitation networking will use groundbreaking concepts of plant microbiome precision detection and engineering of synthetic communities syncoms of bcas supported by artificial intelligence aibiomehealth structure has six interdependent wps wp1 is for coordination and management wp2 deals with ri on precision detection and control of phytobiomes also challenged by climate change as a case study we will use pearapple trees under an rcp85 climatic scenario and challenged with erwinia amylovora and stemphylium vesicarium new detection toolsmatrices eg aerobiomes dynamics hostmicrobiomepathogen and syncoms will be unveiledtested for the rcp85 condition wp3 precision detection and wp4 control using syncoms are dedicated to the capacitation of requimteup with dedicated shortterm visits trainingadvanced courses summer schools etc wp5 will build a sustainable structure through a ri roadmap of requimteup for 2030 and the creation of a centre of plant pathogen detection and control finally wp6 deals with disseminationcommunicationthis 36month twinning will boost the precision detectioncontrol of diseases in portugal increasing its networking competitiveness and international recognition
knowledge management and models of interoperability in peace operations

un peacekeeping operations constitute a complex endeavor to prevent conflict and protect civilians which often can only be achieved through close collaboration of different nations functions and services both military and civilian although interoperability is crucial for the success of integrated missions no previous study has systematically examined differences in models of interoperability along national lines furthermore until now the taxonomy of knowledge requirements for effective interoperability remains disorganized and undertheorized in scholarly literature previous experiences in missions have demonstrated that military peacekeepers even when operating under the same mandate may have different understandings of the abilities and skills required to interact with other contingents and services in missions this project sheds light on such unexplored issues through case studies and comparative research it aims to identify and assess how knowledge management across different national peacekeeping organizations affects variations in models of practices of interoperability in peace operations as case studies i have selected four national peacekeeping training organizations located in different nations and regions india brazil netherlands and ethiopia given the projects focus on the field of peace and conflict studies it adopts a strong interdisciplinary approach to ensure the successful development of the purpose of this project i will conduct my research at the netherlands defense academy under the guidance of professor dr ren moelker a leading scholar in the field this project will prepare me to become a tenured scholar refine my research skills strengthen my scholar profile and enable me to establish myself as an experienced researcher
geneindependent combination therapy for rodcone dystrophy

rodcone dystrophies are inherited retinal diseases whose clinical course begin with the degeneration of rod photoreceptors and evolve with the progressive loss of cones that in turn leads to complete blindness these diseases affect 12500 individuals worldwide with many underlying gene defects although gene replacement therapy has been very successful in treating inherited retinal degenerations in the clinic with one fda approved product on the market and over 30 clinical trials it is costly and time consuming to develop a gene replacement therapy for each mutation moreover gene replacement can only be helpful if the underlying mutation is known and recessivedespite the genetic heterogeneity of these diseases as well as their inherent complexity all rodcone dystrophies converge on a common phenotype of rod cell loss followed by cone cell degeneration first in the periphery and then in the fovea leading to complete blindness a gene therapy approach aiming to counteract the symptoms of rodcone dystrophy rather than the individual genetic causes has the potential to be helpful in the highest number of affected patientsin this action we propose to develop a combination gene therapy to restore light sensitivity in mouse models of rodcone dystrophies aavmediated expression of optogenetic channels in cone photoreceptors will restore light sensitivity and maintain downstream retinal circuitry processing the optogenetic therapy will be combined with the aavmediated delivery of rod derived cone viability factor rdcvf a factor normally secreted by rods to promote cone survival lost in rodcone dystrophies rdcvf expression in combination with optogenetic channel expression will promote survival of newly lightsensitive cones furthermore this action proposes to deliver optogenetic channels and rdcvf to human retinal organoids showing expression and photoreceptor activation in human tissue in vitro
between the sacred and the mundane a historical inquiry into travel and travelling practices on the ottoman pilgrimage road from üskudar c 15171800

the hajj caravan was likely the largest and most regular flow of peoples and commodities through the arteries of the ottoman empire yet surprisingly little is known about the experiences of ottoman pilgrims who took the overland route to mecca and medina each year ottohajj will investigate early modern c 15171800 ottoman travel through an indepth study of the material and human aspects of the caravan from skdar to mecca the project has four main objectives undertaking research in manuscript libraries in order to build a corpus of ottoman hajj guidebooks authored by pilgrims classification and analysis of these sources exploring intertextuality authorship and milieu of authors investigating the infrastructure of pilgrimage in order to produce a typology of locations including sacred sites facilities and places of leisure rest and relaxation constructing a typology of social profiles and associated traveling patterns of pilgrims the use of guidebooks will be supplemented by other ottoman turkish and arabic sources including travelogues chronicles documents objects and images the project will provide data on the diverse territories of the former ottoman empire and traveling practices within them a crucial undertaking since climate change and rapid urban transformations continue to irreversibly alter the landscape and diminish ecological diversity this data will allow us to better understand the social religious cultural ecological and scientific history of the early modern empire the project will also make important contributions to the study of manuscript cultures and the application of digital humanities in ottoman studies project outputs include a monograph on traveling practices and mobility a critical edition of a latesixteenthcentury manuscript guidebook digital maps of locations and network maps of guidebook authors a project website promoting open science and open access and participation in conferences and symposiums
bioengineered microbes as a platform for discovering chemical rescuers of diseaserelated misfolding of integral membrane proteins

protein misfolding diseases pmds are a large group of human disorders caused by the misfolding of specific proteins they include conditions with high socioeconomic impact such as alzheimers disease cystic fibrosis obesity and type 2 diabetes and the majority of them remain incurable among the 70 pmds about 13 are caused by misfoldingprone membrane proteins mismps despite their significance and mainly due to the difficulties associated with mismp overexpression isolation and characterization the pmd scientific community has largely overlooked mismpassociated pmds thus limiting opportunities for drug discovery in promisme we will develop engineered bacteria and yeast which can function as broadly applicable discovery platforms for compounds that rescue mismp misfolding these compounds will be selected from libraries of druglike molecules biosynthesized in these microbes using a technology that allows the facile production of tens of millions to tens of billions of different test molecules these libraries will then be screened in the same microbial cells that produce them and the rare molecules that rescue mismp misfolding effectively will be selected by ultrahighthroughput screening the effect of the selected molecules on mismp folding will then evaluated by biochemical and biophysical methods while their ability to reverse mismpinduced pathogenicity will be tested in appropriate mammalian cell assays the molecules that rescue the misfolding and associated pathogenicity of the target mismps will become therapeutic candidates against the corresponding diseases this procedure will be applied for different mismps to identify potential therapeutics for two serious pmds usher syndrome iii and charcotmarietooth disease successful realization of promisme will provide invaluable therapeutic leads against major diseases and a more widely applicable framework for drug discovery against diseases caused by membrane protein misfolding
material decomposition in xray phasecontrast imaging with coherent sources

xray microtomography is increasingly popular at synchrotron sources worldwide the high flux and excellent beam properties allow for a fast threedimensional visualization of various kinds of specimens at micrometre spatial resolution and exceptionally high image quality but all these imaging instruments use the unique synchrotron sources merely to depict the objects internal structure all further quantitative information encoded into the data remains unused the reason is a lack of an image retrieval method which accurately models the whole image formation process with highlycoherent radiation on the micrometre scale to extract all contained information from a single exposure consequently these microtomographic images always contain a mixture of different signals based on various interaction effects namely attenuation refraction and scattering accurately separating all the signals will allow to quantify concentration and microstructure of materials of interest and to locate them inside the object which is unattainable in a single exposure at the moment the main goal of this project is to enable simple and fast xray microtomography at highlycoherent sources to fully exploit the disregarded information contained in the imaging data my team will develop a robust algorithm for accurate signal separation modelling all interaction effects and demonstrate the benefit of material decomposition for highlighted applications with this tool at hand our ambition is to fundamentally change the way of imaging at modern synchrotron sources imaging will no longer be solely a morphological method as quantitative and materialspecific information will become standardly available in fast microtomography at all coherent sources worldwide
modeling misspecification incorporating information processing biases into economic models

differences in how individuals interpret the same information have proven to play an important role in societal decision making yet most economic models assume individuals not only interpret information correctly but fundamentally agree on how information should be interpreted in modelmisspec i will develop a unified framework that links two approaches to modeling information processing biases i plan to i develop a unified framework to model information processing biases ii develop tools both theoretical and empirical that can be applied to the analysis of problems this framework and iii bring this framework to bear on applied models to study to the role of biases in price dynamics learning reputation and other applicationsthe proposed project has theoretical empirical and applied components in the theory part i will develop a unified framework that bridges two common approaches to modeling biases this approach provides a transparent and general framework for modeling information processing biases ill then use this framework to explore the implications of information processing biases for decision making in the second part i study misspecification empirically in the first empirical component i will experimentally elicit a key part of this framework the forecast this object is an key piece of decision making that has gone unstudied i also will study misspecification in the field through a survey of finnish drivers beliefs about the penalty schedule for speeding this section will focus on both developing tools for studying misspecification empirically and its implications for decision makingfinally i plan to explore the economic applications of this framework including timing games social learning reputation markets etc
biomass to bioemethanol by breakthrough soecbased process the bebop innovation

methanol is a crucial commodity in the chemical sector and a potential building block of the future sustainable chemical industry to date the majority of methanol is produced from fossil fuels either natural gas or coal with associated co2 emissions of 03 gtyear about 10 of total chemical sector emissions biomass is a sustainable alternative to conventional hydrocarbon feedstocks however due to its high carbon and oxygen content conventional secondgeneration biomasstomethanol processes achieve 4045 of carbon efficiency and result in venting most of the carbon back to the atmosphere as co2bebop is a 4year project that aims to develop a novel versatile disruptive and multiproduct biomass and power to methanol plant that can transform the methanol industry thanks to the integration of an electrolysis cell within the syngas conditioning line the bebop concept can double the methanol productivity ans achieve 95 of total carbon efficiency and recover high value components from biomass gasification residuesthe bebop project will showcase a firstofakind trl6 pilot plant ready to be scaledup and replicated by the european biomassbased industry bebop will enhance market opportunities in the short to medium term bringing the methanol production costs below 250 t with longterm lowcost renewable electricity and including 150 tco2 carbon credits and shifting the 10 of the production from fossilbased to bebop configuration allowing to avoid the emission of more than 30 mt of co2 per year 3 of co2 emissions in chemical industry preserving the quality of the end product at competitive costs decreasing the ghg emissions decreasing the costs of methanol production and creating new direct and indirect jobs bebop will have a decisive impact in increasing the circularity of the european chemical sector