Dragon09/odtu_chatbot huggingface dataset:
developing novel inhaled bioengineered extracellular vesicle rna based advanced therapeutics delivered by tailored aerosol delivery technology for the treatment of lung cancer

lung cancer lc treatments have advanced in recent years with the advent of genetic profiling and immunotherapy however lc is a complex heterogeneous disease and survival rates remain poor rna mrna microrna other noncoding rnas and nucleic acid based modulators of same and gene therapies dna or gene editing for delivering nucleic acidbased therapeutics have curative potential for a host of indications previously untreatable they have yet to enter the mainstream due to safety concerns and difficulties delivering them efficiently to areas other than the liver kidney and circulatory system aerosol delivery allows direct targeting of lung tissues but viscous mucus in the lung is a significant barrier to gene transfer to the target cells of the lungs even if the mucus layer can be penetrated inefficient penetration through the cell membrane further impedes access of these vectors to the underlying target cells thus preventing successful gene transfer delivery is a major barrier to successful pulmonary gene therapy for competing viral and nonviral gene transfer vectors and the vast promise of gene therapy has many challenges to overcome omnis novel solution is pioneering the use of genetically modified msc evs with a proprietary surface engineering technology to further enhance delivery through the mucus barrier and into the targeted lung cells this platform technology also combines efficient aerosol delivery of the evs via aeros proprietary state of the art vibrating mesh nebulizer technology this unique solution solves the problems associated with lung targeted delivery of rna based advanced therapies
deciphering cellular and viral determinants of lytic hsv1 infection latency and reactivation

herpes simplex virus 1 hsv1 is an important human pathogen which infects the majority of the worlds population and inflicts a substantial burden of disease over the past 10 years systems biology approaches to which my lab has provided seminal contributions have substantially broadened our understanding of the complex interaction of this common pathogen with its human host however the underlying molecular mechanisms remain poorly understood and their importance for virus latency and reactivation remain elusive furthermore currently available technology lacks the temporospatial resolution to decipher the cellular and viral determinants that govern the virus life cycle the main goal of decipherhsv is to close these knowledge and technology gaps and decipher novel mechanisms and their functional interplay by which hsv1 manipulates its host cells throughout the virus life cycle accordingly the three primary objectives of decipherhsv are to i decipher the full complement of viral elements that govern productive infection ii decipher how and why hsv1 manipulates pervasive transcription within the host and viral genome and iii decipher the cellular and viral determinants of hsv1 latency and reactivation alongside i will develop new computational approaches and integrative analysis tools and employ artificial intelligence to exploit the wealth of information that is provided by the novel single cell rna sequencing approaches which i will pioneer heterogeneityseq and perturbscslamseq thereby i will deliver new leads for novel therapeutic approaches targeting hsv1 latency and reactivation this will provide a paradigm for the study of other herpesviruses and their complex hostpathogen interactions
bioinspired singlet fission photon multipliers

the european union eu revised renewable energy directive 20232413eu states the need of advancing renewable energy sourcesto meet the commitments of the paris agreement while keeping the eu a global leader in renewables among the existing renewableenergy technologies photovoltaics are one of the most mature promising to reach a worldwide production of 8519 gw by 2050siliconpvs sipvs are the most advanced approach to reach the above goal at low costs however they still face the problem ofthermalization an energy loss mechanism by which the excess energy of the absorbed photons with respect to the si band gap islost biosinfin will tackle this issue developing the first bioinspired photomultiplier coating based on singlet fission a multiple excitongeneration process here singletfission active chromophores and redemitting materials are bioconjugated to protein scaffolds withnm precision and used to fabricate a coating to sensitize si solar cells promising up to an additional 5 to the absolute powerconversion efficiency of commercial si pvs ie about 25 improvement using a lowcost and sustainable coating leading a revalueof sipv market of up to 15 this multiphoton protein family and its respective coatings will allow to realize a lowcost sustainable environmentally friendly and highly performing new generation of multiphoton lowenergy biohybrid emitters of great interest for photonics with a final proof on overcoming thermalization in silicon solar cells helping the eu to fulfil the revised renewable energydirective
understanding the working mechanisms of quaternary blend organic photovoltaics opvs

in response to recent climate tragedies european union eu is taking rapid action with its ambitious european green deal egd to transform our economies and societies greener as a result the eu is encouraging the transformation of our buildings and vehicles from energy consumers to energy producers by installing lightweight flexible colourful transparent lowcost and environmentally friendly solar panels these are precisely the features of organic photovoltaics opvs despite the benefits the commercialization of opvs has yet to occur with power conversion efficiency pce being the primary impediment in recent years significant advancements in developing novel design architecture such as quaternary blend systems qopvs that employ cuttingedge nonfullerene acceptors nfas helped achieve pce of over 18 however a lack of understanding of the fundamental mechanisms behind novel qopvs has impeded further advancement as a result dr arunagiri lingeswaran experienced researcher er intends to solve this issue by employing advanced spectroscopic techniques to develop a new design rule for fabricating oneofakind and highly efficient qopvs that go beyond the stateoftheart er intends to bring an efficiency breakthrough in the opv field by utilizing the intermultidisciplinary aspects of research involving physics chemistry materials science and device engineering to achieve this ambitious goal using the host institutions excellent infrastructural resources the proposed project qubics complements the ers expertise in fabricating cuttingedge qopvs and the host scientists knowledge of studying device physics overall the new skills and expertise obtained via this fellowship will help er mature into a better researcher capable of managing his research group in a few years ideally in europe his desired career path
next level quantum information processing for science and technology

quantum computers are extremely promising emerging technologies with interdisciplinary teams around the globe working on their development and implementation yet progress is hampered by fundamental difficulties in scalability enduser friendliness certification of components and algorithms and limited application scope to realworld problems to overcome these urgent challenges neqst leverages an extended quantum information processing paradigm based on multilevel carriers of quantum informationqudits both the quantum hardware at the fundamental level and many problems of scientific and technological relevance are expressed in terms of multilevel systems making this approach the most efficient choice to unlock the full potential of quantum computers and simulatorsneqst will generate foundational breakthroughs in the full value chain of qudit quantum information processing these include qudit based firmware with scalable characterization and automatized design tools harnessing a larger hilbert space an enduser friendly highlevel control and simulation software enabling nonspecialists to utilize the qudit hardware the efficient simulation of quantum models of scientific relevance such as gauge theories the solution of optimization problems in academia and industry naturally phrased in terms of multilevel variables and certification tools specifically designed for multilevel quantum information enabling a deviceindependent validation of data neqst results will therefore elucidate the role of dimension in quantum physics and its use as a resource for quantum information processingto achieve its ambitious goals neqst has assembled an interdisciplinary team of leading academic and industry partners and has developed a wellrounded work plan as well as detailed dissemination and exploitation strategies
gap resolution in safety nutritional allergenicity and environmental assessments to promote alternative protein utilization and the dietary shift

accelerating the transition from animalbased to alternative dietary proteins the dietary shift is key to reducing the footprint of our food system in terms of greenhouse gas emissions ghg energy water and land use and other relevant environmental impacts and for improving the health and wellbeing of people animals and the planet giant leaps delivers the strategic innovations methodologies and openaccess datasets to speed up this dietary shift in line with the farmtofork strategy and contributing to the green deal target of reaching climate neutrality by 2050 achieving the dietary shift in practice is inherently complex due to the diverse set of actors involved and further hindered by major knowledge gaps scattered across the various alternative protein sources and the domains of health safety allergenicity and digestibility environment ghgs and other environmental and climate impacts biodiversity circularity andor barriers to adoption technological sensory and consumer acceptance the giant leaps consortium consists of the key actors and spans all expertise to address relevant knowledge gaps and proactively engages to arrive at optimized future diets based on alternative proteins that are broadly accepted across stakeholder groups in order to deliver required insights for short mid and longterm decision making and impact giant leaps protein sources have been selected for either targeted or full assessment based on their current level of specification the innovations and improved methods combined with accessible and comprehensive information generated for a wide collection of alternative proteins will enable policymakers to prioritise changes in the food system towards the dietary shift based on desired impact value chain actors to make strategic scientific business and investment choices and the general public to make more sustainable and healthy dietary choices
flexible channel coding for 6g short packet communication

the emerging sixthgeneration 6g of mobile networks will be a key part of the solution to the constantly increasing problem of urbanization and the digital divide 6g has aligned its focus to the united nations sustainable development goals sdgs and aims by 2030 to achieve the following targets a empower people by providing services and solutions to individuals and society b sense the environment by performing extensive hyperlocal measurements and c strengthen the world by reinforcing the ecosystem according to the sdgs key 6g use cases such as wireless factory automation and autonomous driving will require ultrahigh reliability and ultralow latency highresolution localization and highaccuracy interdevice synchronicity these requirements are well beyond the capabilities of existing mobile standards including the fifthgeneration 5g mobile short packet communications play a key role in meeting the low latency requirements of many 6g applications despite recent progress the design of effective channel coding and decoding techniques for short packet communications is still far from sufficiency 6g communication systems require flexibility in the blocklength and coding rates short and moderate blocklength codes approx from 100 bits to a few thousand bits with closetooptimal performance are required for 6g a promising solution is rateless codes carefully optimized for short blocklength and able to provide flexibility in code rates blocklength and decoding complexity the main objective of this project is to develop new rateless coding schemes and decoding algorithms to address the flexibility and bitgranularity for finite blocklength channel codes and to design lowcomplexity decoding algorithms to address the latency issue in 6g short packet communications it is expected that our results can largely improve the performance of 6g networks in terms of latency reliability flexibility and complexity
surgical optogenetic bioprinting of engineered cardiac muscle

heart failure remains a leading cause of mortality worldwide taking an estimate of 16 million lives each year cardiac tissue engineering solutions that can improve the quality of life of those with advanced heart disease have proved challenging so far bioprinting is an exciting technology that holds promise to fabricate tissues and organs labgrown engineered cardiac muscle requires at least four weeks to maturate in a bioreactor in lightheart an offtheshelf solution will be developed for treating injured myocardium in vivo an unconventional combination of bioprinting and optogenetics will be used to surgically fabricate engineered cardiac muscle directly at the patients heart a surgical bioprinting tool will be constructed to achieve vascularization and cellular architectures as that observed in native cardiac muscle induced pluripotent stem cellderived cardiac cells will be the basis of the bioinspired biomaterialfree ink that will be printed optogenetic expression of different lightsensitive proteins at the cell surfaces will be the sole trigger of cellular assembly thus omitting the need to embed cells in hydrogels or printing in a supporting bath surgical optogenetic bioprinting will be first tested ex vivo using a silicone human phantom with a mimicking beating heart and later in vivo in a large animal model in accordance with the 3r principles lightheart opens up new horizons in the way heart failure can be clinically treated and brings hope to patients who are desperately waiting for a heart transplantation the disruptive nature of lightheart will unite engineers surgeons and scientists to change the future of transplantation medicine with modular bottomup technologies that allow for in vivo tissue and organ restoration or replacement directly at the operating theatre
nanoengineered coionic ceramic reactors for co2h2o electroconversion to light olefins

as a major contributor to the global co2 emissions the commodity chemical industry should be urgently coupled with renewable electricity to become independent from fossil fuel resources ecolefins aims to establish a new allelectric paradigm for the electroconversion of co2 and h2o to light olefins the keyintermediates for polymers and other daily life chemical products the proposed concept reverses the heavy co2 emissions associated to the petroleumbased light olefins production to massive co2 capture and valorisation for carbon negative ethylene propylene and butylene the concept introduces coionic ceramic membrane reactors and shortstacksmodules that merge the anodic steam electrolysis for hydrogen production with the cathodic co2 electrolysis and hydrogenation to light olefins over tailored and nanoengineered electrodes aiming to develop a substantially more effective technology for the singlestep respowered artificial photosynthesis of co2 to valuable chemicals this ambition entails a multidisciplinary task requiring highly tuned synergies among cutting edge research in the fields of i advanced materials science engineering for coionic composites perovskite exsolutions and organometallics ii electrochemistry and electrochemical process engineering iii catalysis science and engineering iv computer aided materials design and atomic scale modelling and v digital realscale process modelling and economic evaluation along with a comprehensive sustainability assessment applied social research for impact framing and marketization planning
early interception of inflammatorymediated type 2 diabetes

the overall concept of interceptt2d is to establish whether an inflammatorymediated profile contributes to the onset of type 2 diabetes t2d complications thus enabling the identification of patients most at risk of complications and the design of personalized prevention measurest2d is a heterogeneous disease which is an obstacle to the delivery of an optimal tailored treatment consequently patients individual trajectories of progressive hyperglycemia and risk of chronic complications are so far difficult to predict in this context onset of diabetic complications represents the most important transitional phase of t2d development toward premature disability and mortality chronic systemic inflammation has been suggested to be a major contributor to the onset and progression of t2d complications interceptt2d will bring a new and clinically relevant dimension in t2d care considering at diagnosis inflammatory parameters that are of importance for the transition to t2drelated complications the combination of stateoftheart genomics and cellbiology technologies with targeted clinical interventions should lead to potent patients stratification it should allow the identification and prognosis of a novel class or subclass of patients characterized by an inflammatorymediated t2d endotype the project has access to the bestdocumented longitudinal human european cohorts of patients with t2d with reliable clinical and biological data allowing to trace the transition and evolution towards organ complications this added to the exploitation of an extensive health data warehouse will enable us to establish the inflammatory trajectory of citizens with t2d from diagnosis to the development of complications to explore the ability to prevent the transition phase of t2d towards organ complications interceptt2d will conduct a phase ii clinical trial with an antiinflammatory therapy targeting nlrp3 inflammasome activity in patients with t2d
a comprehensive translational research and training pipeline harnessing lipid metabolism to improve prostate cancer management and educate young researchers in tackling complex disease

prostamet is an immersive doctoral network dn that aims to train the next generation of researchers tackling complex multifactorial diseases including cancer that are typically characterized by an outspoken inter and intrapatient heterogeneity and that increasingly face our ageing society despite unprecedented technological advances to dissect disease into its smallest details the translation into costeffective and personalised treatment approaches is one of the timeliest challenges that face the scientific community and that require a specific transdisciplinary mindset and education focusing on prostate cancer as a key paradigm of such a complex disease and as one of european health unions new focus areas for organised screening prostamet aims to bridge current gaps in translational research capitalising on the underexplored clinical potential of altered lipid metabolism in cancer through a close collaboration among wellselected academic and nonacademic partners with highly complementary expertise prostamet aims to set up a unique lipidfocused translational research pipeline from cuttingedge spatiallyresolved molecular discovery through validation in goldstandard models all the way to innovative drug development through its modular and bidirectional nature with multiple entry points this pipeline is expected to generate outputs at multiple levels of the drug development chain for sustainable downstream valorisation through a combination of highlevel technological handson research nonacademic placements and coursesworkshops on scientific and complementary soft skills facilitated by the academicnonacademic composition of the consortium prostamets ambition is to provide young researchers with a creative and holistic view on translational research along with strong transferable skills to prepare them to take up thriving careers in a transformative health care system focusing on personalised precision medicine
port solutions for efficient effective and sustainable multimodality

multireload focusses on the specific role and challenges of inland ports as multimodal freight nodes in reaching europes greenhouse gas ghg reduction target of at least 55 by 2030 thereby shifting a substantial part of the 75 of inland freight carried today by road in the eu to inland waterways and rail and by increasing operational efficiency safety and reliability of existing infrastructures through digitalization inland ports are key for multimodal transport chains both continental and maritime transport without efficient nodes in the hinterland multimodal transport is not possible however the constraints and barriers are much higher in inland ports space urbanisation demand investments than in seaports multireload enhances the collaboration between different freight nodes in europe to jointly test innovations and create favorable market conditions for multimodal freight transport solutions multireload will demonstrate solutions in three innovation areas with specific aims by 2025 mirroring measures of the eus smart mobility strategy a smart multimodal logistics facilitate a shift from road to rail iwt of 5 b digital automated multimodal nodes and corridors increase operational efficiency by 20 raise of handling capacity c innovative business models leading to an average cost reduction of freight transport by 10 multireload involves highly ambitious logistics hubs including the multimodal node duisport de duisburgs highly ambitious port and the worlds largest and most advanced trimodal inland hub terminal and the trimodal nodes ports of vienna at and basel ch the project is backed up by additional funding financing for better integration of the freight transport nodes into overall logistic chains of about 450 mio eur multireload involves a total of 22 partners comprising of highly innovative technology logistics and service providers leading european research institutions and wellconnected networks