Dragon09/odtu_chatbot huggingface dataset:
interactive tools for the study and the enhancement of music iconography

while music is undoubtedly a primary expression of any civilization western society seems to have moved further and further away from the music of its past thus missing a great wealth of its own identity rethinking how we approach historical music is essential to bridge this gap and inmusic intends to make an innovative contribution in this direction the project will focus on a particularly interesting yet littleaddressed branch of cultural heritage music iconography addressing it through a multidisciplinary approach that combines iconological methodology with the application of digital technologiesdue to the very nature of music iconography digital technologies represent a tool with enormous potential for both its study and enhancement in fact only in a virtual context is it possible to reconstruct the original ideal multisensory nature of musical images while digital means allow the socialization of highly specialized musicrelated contents in a dynamic and engaging way nonetheless little has been done to fully explore this potential especially in terms of interactivity inmusic will address early modern spain music iconography and will delve into different digital approaches and communication strategies in order to devise replicable and versatile instruments a semantic database based on cidoccrm and a set of prototypes of digital devices will be elaborated resorting to the use of different opensource software all the prototypes will be submitted to different targets of public who will be asked to fill out a specifically designed survey to collect useful data for the evaluation of the effectiveness of such tools in communicating knowledgethe success of the action will therefore increase our knowledge on spanish musical imaginary in a crucial historic context while providing scholars and cultural stakeholders with efficient means to study teaching and enhance an unconventional heritage
control of rna polymerase ii and transcription factors via idrs

rna polymerase ii pol ii plays a pivotal role in human cellular function carrying out the complex transcription process a unique domain sits at the end of pol ii the cterminal domain ctd the phosphorylation of which offers a mechanism of interaction for transcription factors tfs that regulate the transcription process the spatial organization of tfs around pol ii is moderated by the intrinsically disordered regions idrs of the tfs and ctd and high specificity is required to avoid disease causing defects however the exact mechanisms that maintain this environment and their importance are still unknown here we suggest a method for determining crucial pol ii tf interactions by relating electromagnetic imaging to computer simulations results will be able to delineate individual amino acids responsible for maintaining the spatial organization of the proteins in vitro the simulationbased study will be leveraged to explore the tolerance of maintaining these interactions when encountered with different phosphorylation states of ctd a proofofconcept study is then described which will demonstrate an ability to actively target idrs to stabilize the protein interactions while the results here will be comprehensive for four tfs of interest recql5 scaf4 scaf8 and the soss1 complex the methodology can then be expanded to characterize a library of over 400 tfs such a project has the potential to not only further our understanding of ctds function but also pave a way for designing synthetic treatments that can regulate the transcription process
novel boronbased two dimensional materials as heterogeneous catalysts

the proposal 2dborocat addresses synthesis characterization and catalytic applications of borophene new wonder material thathas attracted extensive attention from the scientific community due to its intriguing properties despite the attractive properties ofborophene lack of facile lowcost and efficient production method restricted its industrial applications therefore major focus have been given in developing a synthetic route to borophene that outclasses the limitations of existing methods and modifies the present stateoftheart synthesis further its use as catalyst in various industrially relevant transformations is suggested for the first time especiallythe proposal addresses one of the defining environmental energy and societal challenges of 21st century the conversion of co2 tovalue added chemicals especially lpg both thermal as well as plasma reactors will be used to accomplish the target of co2 reduction plasma catalysis has the distinct advantage that the conversion can be achieved at a lower temperature and pressure compared to pure thermal catalysis the proposal is highly novel and timely in the present context of global warming due to increasing anthropogenic co2 emissions and diminishing fossil fuel reserves in addition to this other important reactions such as oxidative dehydrogenation odh and ammoniaborane hydrolysis etc will also be investigated 2dborocat is expected to create huge scientific economical and societal impact in terms of co2 mitigation strategies
bringing eusolaris eric to its zenith

the solarize project intends to enhance the longterm sustainability of the eusolaris eric by successfully achieving its general objectives enlargement of the membership further involvement of rd institutes and national funding institutions at the national nodes educating new researchers to make appropriate use of the ris reinforcement of international cooperation and of science diplomac improvement of the managerial skills of its staff strengthen the interaction between industrial stakeholders and cst researchers increase of the general awareness of other possible applications of cst ris eg industrial process heat development of new standards and testing protocols creation of the first einfrastructure providing remotevirtual access to the rd centres study of best ways to combine cst with other energy sources and last but not least targeting the greening of technologies and methodologies used by the cst ris
metal matrix nanocomposite coatings utilization as alternative to hard chromium

the mozart project proposes sustainable coating solutions for replacement of hard chromium in specific applications based on nanocomposite electroplating processes nanocomposite coatings are potential candidates as durable protective coatings in applications where high wear and corrosion resistance is needed their significant advantage compared to other alternative solutions to hc is that they can be produced from the existing infrastructure of plating shops by applying lowcost modification in the lines for the safe integration of nanoparticles keeping thus the investment level low the mozart project proposes a multidisciplinary approach for achieving high quality durable composite coatings as replacement to hard chromium the proposed technologies have been already validated in the lab scale trl 3 on previous ec national or institutional projects and will reach trl 5 by the end of the project validated in pilot scale and real demonstrators the proper integration and combination of these technologies will bring the nanocomposite coatings to the desired technology maturity more specifically during the mozart project a combination of technologies will be used under a safe sustainable by desing strategy insilico method artificial intelligence and simulations online monitoring technologie chemical functionalization of nanoparticles and advance electroplating techniques the novel nanocomposite coatings will be tested in demonstrators introduced from companies smes or les in the field of manufacturing automotive and machinery
marine munition in europe solutions with economic and ecological profits for efficient remediation

the mminesweeper project will advance knowledge capability and capacity in europe for dealing with marine munition in the nonmilitary aspect of uxoclearance 21 partners from 7 eu and 2 associated countries bring experience and capabilities from the civil science community 9 military research 3 coastborder guards or eodservices 4 as well as industry 3 and intergovernmental organizations 2 jointly they will work in 8 technical work packages to a advance automated munition detection identification and data analyzing technologies and software b environmental monitoring of chemical contaminants c predictions of uxoburial contaminants spread and the stateofcorrosion and will d enable secure exchange of sensitive data 64 of person months three additional wps will compile existing knowledge learn about the legal responsibilities and technical approaches assess remediation and mitigation measures and create training material for building european capacity 14 pm two wps will engage in an intense stakeholder dialog and disseminationoutreach activities by utilizing capacities already existing at helcom and jpio 14 pmoutcomes with respect to specific technical advancements will include a aisupported detection of munition in hydroacoustic spatial mapping data mbes sss sas b detection of buried munition objects magnetic sbp lfsas c aisupported object identification in optical and acoustic cameras and d implementing trained aimodels into smartauvs and usvs for adaptive and cooperative mission execution all this will utilize secure data exchange possibilities through a demonstrator data platform that will be refined during the project industry partners see a great benefit in developing technologies that later can be advanced further to become commercial products at the end of the project most trls will be at 5 to 6 meaning they have been applied under real conditions and proved their applicability
simulationenhanced highdensity magnetomyographic quantum sensor systems for decoding neuromuscular control during motion

being able to decode neural signals that control skeletal muscles with high accuracy will enable scientific breakthroughs in diagnostics and treatment including early detection of neurodegenerative diseases optimising personalised treatment or gene therapy and assistive technologies like neuroprostheses this breakthrough will require technology that is able to record signals from skeletal muscles in sufficient detail to allow the morphofunctional state of the neuromuscular system to be extracted no existing technology can do this measuring the magnetic field induced by the flow of electrical charges in skeletal muscles known as magnetomyography mmg is expected to be the gamechanging technology because magnetic fields are not attenuated by biological tissue however the extremely small magnetic fields involved require extremely sensitive magnetometers the only promising option is novel quantum sensors such as optically pumped magnetometers opms because they are small modular and can operate outside of specialised rooms our vision is to use this technology and our expertise in computational neuromechanics to decode for the first time neuromuscular control of skeletal muscles based on in vivo highdensity mmg data for this purpose we will design the first highdensity mmg prototypes with up to 96 opms and develop custom calibration techniques we will record magnetic fields induced by contracting skeletal muscles at the highest resolution ever measured such data combined with the advanced computational musculoskeletal system models will allow us to derive robust and reliable source localisation and separation algorithms this will provide us with unique input for subjectspecific neuromuscular models we will demonstrate the superiority of the data over existing techniques with two applications signs of ageing and neuromuscular disorders and show that it is possible to transfer these methodologies to clinical applications
web3 platform for formal mathematics

mathematics is today on the verge of a revolution formal computerverified proofs become ubiquitous and largely adopted as the new means of communication and collaboration this led to landmark proofs such as haless verification of the kepler conjecture and scholzes condensed mathematics recently validated by computers generating considerable momentum in the mathematical community simultaneously there is growing industrial demand for formal proofs of software and hardware similarly web3 constitutes a transformation of how data and collaboration are realized in a decentralized intelligent and interconnected wayin this project we will develop a web3 platform for formal proofs designed to establish connections between mathematicians researchers in formalization communities and businesses this platform will also integrate stateoftheart verification ai and autoformalization tools to assist in the creation of computerunderstandable proofs the proposed work will include the development of a wiki for formal mathematics with integrated blockchainbased tokens that reward users for their contributions we will provide translations for various logics and proof systems and investigate the safety and security of the protocols on the business side we will conduct market research engage potential customers clarify intellectual property rights and formulate licensing solutionsthe project builds on the success of our erc project smart where we have already developed software that harnesses artificial intelligence for advanced logical reasoning and proposed novel approaches to decentralizing proof verification using blockchain technology in the current proof of concept project we aspire to expand these software capabilities into a holistic web3 platform that will serve as a collaborative hub enabling diverse stakeholders to collaboratively address practical verification and formalization challenges while rewarding users for their contributions
targeting mechanisms of thromboinflammation

the recent covid19 pandemic dramatically illustrated i the clinical relevance of thromboinflammation the interplay of coagulation and inflammation and ii our limited understanding of molecular mechanisms of thromboinflammation thromboinflammation is a frequent diseasedriving mechanism impairing outcome of viral or bacterial infection cardiovascular disease cancer and other diseases the lack of mechanistic insights hampered the development of specific therapies my group recently discovered a new molecular link between coagulation and inflammation that addresses this enormous unmet medical need the initiator of coagulation tissue factor tf f3 cd142 forms a previously unknown heterodimer with the cytokine receptor ifnar1 interferonalphabeta receptor alpha chain on resting cells in this heterodimer tf and ifnar1 are both inactive upon stimulation eg fviifviia lps polyic the heterodimer dissociates activating tfmediated coagulation ifnar1mediated inflammation and cellular metabolism this provides a novel yet simple molecular switch simultaneously controlling coagulation inflammation and metabolism this switch is expected to provide a new conceptional framework for thromboinflammatory diseases to enable future translation of this novel mechanism i aim to address the following open questions i how is this molecular switch regulated in an organ and context specific fashion in vitro work cellspecific inducible tfifnar1 deficient mice ii what are the consequences of this molecular switch for intracellular signaling inflammation mitochondrial metabolism omics with bioinformatic analyses and iii what are the molecular structures required for the tfifnar1 interaction crosslinking crystallography phage display computational modeling i expect that answering these questions will lead to new diagnostic and therapeutic approaches revolutionizing the way we detect and treat thromboinflammatory diseases
uncovering the inner workings of galaxies at cosmic noon

lookback studies have assembled a fairly complete census of galaxies over 85 of cosmic time and established that the bulk of stars which today reside in massive ellipticals and spirals formed rapidly at redshift z13 most of this star formation took place in massive gasrich turbulent disks which already followed tight scaling relations in their global properties and in which dense bulges fast growing central black holes and galactic winds were ubiquitous the next frontier is to uncover the physical mechanisms inside galaxies that govern the buildup of stars and the emergence of galactic structure this goal can only be reached by resolving gas motions and distributions on the toomre scale of 1 kpc at z1 requiring 25 times sharper views than typically achieved so far revolutionary improvements in observing sensitivity and resolution now make this possible the advent in 2022 of the most advanced nearir adaptive opticsassisted integral field spectrograph eris at the very large telescope galphys centers on an ambitious 900hour eris guaranteed time program led by the applicant and exploits key synergies with cuttingedge submillimeter interferometry at iramnoema and alma of which the applicant is a core member of guaranteed and open time programs the requested 3 postdoc and 2 phd positions are required for the pi to establish a research group to execute the program galphys will produce breakthroughs in the most important outstanding issues in galaxy evolution 1 mass and angular momentum transport 2 the origin of gas turbulence 3 the evolution of giant starforming complexes and 4 the physics of outflows powered by stellar and agn feedback galphys will provide excellent training for junior scientists and an unmatched benchmark of lasting legacy in galaxy evolution
development of novel integrated sequencing methods to explore translation and its regulatory mechanisms in single cells

in recent years novel singlecell sequencing methods have allowed an indepth analysis of the diversity of cell types and states in a wide range of organisms due to the continuous optimization of experimental and computational methods by many research groups it is now possible to sequence the transcriptomes of thousands to millions of individual cells albeit an exciting development transcription only covers the first step in the central dogma the second step the process of translation is currently much harder to explore in single cells building upon existing ribosome profiling protocols our laboratory recently majorly increased the sensitivity of these assays allowing ribosome profiling in single cells however currently no methods exist to determine the translation efficiencies in single cells and to correlate translation efficiencies to trna levels and their modifications rna bound proteins and m6a methylation of mrna all major regulatory mechanisms of translation the overarching goal of this proposal is to develop several novel multiomics approaches to quantify translation in single cells by integrating information on ribosome position along the transcript trna expression levels trna modifications rnabound proteins and the m6a methylation status of the transcript these technologies will open novel avenues to start exploring translation and its regulatory mechanisms with singlecell resolution whereas major discoveries have been made during the last decade by exploring the genome the epigenome and the transcriptome using singlecell sequencing approaches translation the major second step in the central dogma is still very much unexplored at the singlecell level i hope that the tools presented in this proposal will provide the community with methods to explore and ultimately understand how translation contributes to the astonishing heterogeneity among single cells
identification of best practices for biodiversity recovery and public health interventions to prevent future epidemics and pandemics

epidemics and pandemics most of them caused by zoonotic and vectorborne emerging diseases are globally threatening our health and welfare at an alarming pace prevention of future disease outbreaks will be pivotal to secure human welfare and demands transformative change biodiversityisgoodforourhealth has become a new paradigm in disease risk mitigation consequently nature restoration targeting biodiversity recovery isolated or in combination with public health interventions has been identified as a major disease risk mitigation tool while there are thousands of ongoing and planned nature restoration projects globally we lack knowledge a if such restorations indeed interrupt the infectshedspillspread cascade and mitigate disease risk b or if they rather amplify the risk and c on success factors characterizing restorations that mitigate disease risk beprep will fill this lack in knowledge and provide practical guidance in spatially and temporally replicated field studies and experiments in case studies in europe and the tropics we will study ac and reveal the causal mechanisms of infection dynamics and of drivers along the infectshedspillspread cascade bepreps participatory and transsectorial approach by actively involving indigenous and local communities will enable the identification of success factors of best practice restorations and interventions incl naturebased solutions to guide future biodiversity recovery measures that promote healthy ecosystems these success factors will contribute to a interrupt the infectshedspillspread cascade and b ultimately prevent disease outbreaks the results of beprep help to create a european society prepared and responsive to disease risk beprep will hence accelerate the ecological transition required to meet eus biodiversity strategy for 2030 as a core part of eus green deal and support a green recovery following the covid19 pandemic
circadian control of systemic metabolism in physiology and type 2 diabetes

type 2 diabetes is a global epidemic with prevalence of 500 million the current obesogenic environment favoring high caloric foods and physical inactivity is a major driver of this epidemic an evolutionarily conserved mechanism by which environmental factors impact whole body physiology is through internal biological clocks and the control of circadian rhythms this machinery is a transcriptiontranslation feedback loop that anticipates daynight cycles to optimize organismal physiology however the underlying mechanisms regulating metabolic rhythmicity and its role in type 2 diabetes pathogenesis remain enigmatic cellular energy sensors relay information about the environment to the circadian clock machinery but the extent to which this biology can be modified to improve systemic metabolism is unknown we will uncover mechanisms that underpin the relationship between the circadian clock energy sensors and metabolism and their dysfunction in type 2 diabetes our overarching hypothesis is that synchronizing energetic stressors to the molecular circadian clock may maximize the health benefits on metabolism we will elucidate the mechanism by which the timing of energetic stressors acts on peripheral tissues controlling energy homeostasis we will study temporal dynamics of cell and organ physiology rather than snapshots in time we will integrate omics analyses with rigorous physiological phenotyping of genetically modified mouse models and clinical investigations in people with type 2 diabetes to temporally resolve dynamic networks of transcription protein signaling and metabolites which synchronously control metabolism in doing so we will come closer to understanding the dynamic changes that occur with metabolic dysfunction the work has the potential to make a breakthrough in clarifying underlying mechanisms for molecular regulation of metabolic rhythmicity how this is perturbed in type 2 diabetes and ultimately insight into new treatments