Dragon09/odtu_chatbot huggingface dataset:
searching recent cryomagmatism in ceres and europa astrobiological targets

the motivation of this project is to contribute to the search and characterization for potentially habitable planetary environments during the two last decades missions to the outer solar system such as galileo to the jupiter system cassinihuygens to the saturn system and dawn to the main protoplanets of the asteroid belt have discovered several ocean worlds jupiters moon europa saturns moons titan and enceladus and the dwarf planet ceres show signs that indicate the presence of liquid water in their interiors potentially interacting with organic compounds and hot rocks these ocean worlds are now considered as prime astrobiological targets by the major space agencies esa and nasa this project proposes a strategy to identify freshly erupted materials at the surface of these icy bodies and provide informations on their composition and on the subsurface source specifically it is focused on europa and ceres the most accessible targets for insitu landing missions for this purpose we will experimentally study the processes that aqueous solutions of diverse compositions undergo from their emplacement in the interior of the crust at mediumhigh pressure and relatively low temperature to their subsequent arrival at the surface at high vacuum and much lower temperature infrared and raman spectroscopies and mass spectrometry instruments will be used to characterize the different processes from the source conditions to the surface emplacement and subsequent alteration these techniques are within the science payload of past current and future missions therefore the data obtained in the laboratory will be used as public databases to assist in the interpretation of spectra taken on space missions
tackling fibrosis and inflammation in lama2rd by in vivo modulation of a novel modifier gene

merosindeficient congenital muscular dystrophy lama2rd is caused by mutations in the lama2 gene coding for the 2 subunit of laminin211 merosin typically lama2rd patients with absent merosin are clinically severe and unable to walk while those producing a partially functional merosin are clinically milder i identified a unique family in which the oldest of two affected siblings shows a novel and extremely mild phenotype despite the complete lack of merosin this patient is still ambulant at 33 years with no respiratory insufficiency or cardiomyopathy notably this patient carries the same lama2 lossoffunction mutation as the sibling who followed the typical severe disease course hypothesizing that genetic modifiers in the atypical patient mitigate the consequences of complete merosin deficiency via a novel mechanism i isolated unique ultrarare polymorphisms in genetic factors related to genes expressed in the atypical patient muscle but not in muscle of nonrelated lama2rd patients and i identified a novel candidate modifier controlling both fibrosis and inflammation key drivers of lama2rd pathogenesis given that this modifier is severely upregulated in the control lama2rd patients but highly downregulated in the atypical patient i will decrease its expression in the severely affected lama2rd mouse model dywdyw by using the crisprinterference tool delivered by a single aav9 i will then assess motor strength and endurance in treated mice finally i will isolate highly affected muscles and sciatic nerve to characterize any molecular and morphological change occurring in these tissues upon modulating the modifier gene expression i expect to observe functional improvement in lama2rd animals thus ameliorating their phenotype the proposed project will elucidate novel mechanisms attenuating lama2rd severity and will allow me to design new therapeutic approaches for this disorder for which to date there is no approved treatment
temporary intraluminal bypass device designed to reduce the rate of diverting stoma and its related complication by at least 70

anastomotic leakage of colon content into the abdominal cavity is the most devastating complication associated with colorectal surgery leaks occur in 22 of cases leading to increased hospitalization time higher reoperation rates increased patient mortality additional costs to minimize the risk of a leak surgeons create a loop of the small bowel which is diverted outside the abdominal wall connected to a stoma bag to collect patients feces for 46 months diverting stoma significantly diminishes patients quality of life increases cost of care requires an additional invasive surgery to reverse the stoma our novel device cg100 is an elastic tubular sheath that is positioned at the anastomosis site during the primary colorectal surgery creates an internal bypass for all colon content cg100 is removed nonsurgically 10 days after primary surgery cg100 addresses will improve patient quality of life save 1350 pa lives reduce healthcare costs by 4b pa in eu
pyrepax past present and future of the pyrenean pastures

for centuries the relationships between pyrenean valleys were regulated by pacts called paceras these agreements were intended to maintain peace between valleys hence their name which derives from the latin word pax and to regulate the ownership and use of the natural resource which was at the basis of the pyrenean communities grassland the paceras between valleys on the same side of the frontier have received little historiographical attention and their environmental dimension has barely been studiedpyrepax focuses on the agreements regarding two mountain pastures in the aragonese pyrenees guarrinza and cerbillonar each of them was a common of two valleys the former of ans and echo and the latter of panticosa and broto the project examines the paceras the practices associated with them and their role in shaping the environment since the mideighteenth century more widely pyrepax studies the reciprocal influences between society and nature and the coevolution of those relationships across time the project intends to explain why and how the relationships between human societies and nature have changed by examining the evolution of the paceras and the practices related to themfurthermore pyrepax examines the current situation of the pastures and the communities from a historical perspective and through an interdisciplinary approach ecology and environmental economy by carrying out fieldwork surveys and interviews in the last phase the project will put into dialogue the ancient pacts with local actors natural scientists and regional management authorities with a view to redesigning some paceras thus creating permanent fora for debate based on interdisciplinary scientific knowledge providing tools for bettter management of the pastures promoting economic activity such as extensive livestock breeding fixing population in rural areas and in short achieving social scientific economic and environmental benefits
automated manufacturing production line for integrated printed organic photovoltaics

fleflex2energy is a 48month project with the ambitious goal to manufacture reliable integrated photovoltaics ipvs with differentiated product design through the development of the firstofeachkind automated rolltoroll r2r manufacturing line for organic pvs the f2e manufacturing line consists of the r2r printing automated assembly machines enhanced with robust metrologies for inline quality process control under artificial intelligence ai analysis implementing industry 40 concept f2e ipvs will comply with all the standards codes and product requirements of use in buildings agriculture and automotive sectorsthe novel idea of flex2energy will be realized by 5 objectivesdevelop and upgrade manufacturing tools for design and aesthetics of opv products inline process quality control techniques and easily adaptable equipment design for printed pv technologiesintegrate tools qc equipment to machines to build demonstrate automated pl manufacturing of ipvsmanufacturing high efficiency durable printed ipv products at competitive cost demonstrate and validate ipvs in energy efficient buildings automotive and agriculture industries with minimum environmental and landscape impactdeploy market strategy and bridge the gap between pv and building sectorsf2e will implement innovative ipv products in three dedicated business cases to promote their early adoption and boost the new market demands bipv products will be installed on a public and a heavy industry building façade as energy efficient windows while agripvs will be installed on the roof of a med gh working as a shade curtain system for growth of tomatoes and as energy generator making the gh energy autonomous finally vipvs will be installed on the roof of a commercial ev to increase mileage and also on the roof of a solar carport to provide energy to electric vehicles the ipv products will be evaluated in terms of performance durability social and industrial acceptance
collaboration and pseudepigraphy facing the anonymous in imperial greek literature

in classical philology a discipline which has long relied on the figure of the author authorless texts are an elephant in the room in antiquity however long before the introduction of copyright texts were the universal commons of all those who drew on them authorship was frequently faked forged or anonymized because authorless texts resist the authorbased gravitational structure of literary history they continue to pose a challenge to scholars in the field and have often been marginalizedcollapse tackles this problem by providing a new methodological basis for situating authorless texts in greek studies imperial greek literature in particular serves as a fertile ground to rethink anonymized text productioncollapse aims 1 to reinterpret the forms of anonymization as forms of fan fiction or as attempts to rewrite previous authors 2 to analyze how boundaries between model authors and their subsequent imitators collapsed in greek literature 3 to explore the relation between poems that were ascribed to alleged authors and unattributed texts thus differentiating forms functions and contexts of anonymization 4 to develop a nonnormative terminology and classificatory system that moves authorless texts from various fields to the center of greek literary history three of collapses work packages investigate the centripetal power of the authors name in the attribution of greek texts the other three analyze the dynamics of anonymization and examine the centrifugal forces of anonymitycollapse attempts to subvert the classificatory binary of genuine and authentic texts versus forgeries moreover the inclusion of different fields of knowledge aims to break down theoretical boundaries to neighboring disciplines overall collapse will rethink the processes of anonymization in a groundbreaking way and contribute to a better understanding of interauthorial mechanisms in imperial greek textual production
reducedorder topology optimisation of highresolution microstructures with internal contact

exploiting the full potential of additive manufacturing methods requires a leap forward in advanced modelling and computing techniques while additive manufacturing enables the highprecision fabrication of architectured mechanical metamaterials its design is currently driven by human experience as such it could greatly benefit from numerical topology optimisation to techniques the fftto project addresses two challenges of insilico design of highresolution architectured microstructures first stateoftheart finite element computational homogenisation approaches even when accelerated with highly efficient fast fourier transform fft techniques are too costly for microstructures discretised into billions of voxels i will significantly reduce their cost by developing a novel mesh coarsening technique based on lowrank tensor approximations second as the manufacturing resolutions reach micrometre accuracy and the surfacetovolume ratio increases surface effects including adhesive contact need to be accounted for in the to formulations this project will incorporate adhesive interaction into the lowrank fftbased computational homogenisation scheme as a result the fftto project will deliver computationally and memory affordable algorithms for microstructure to on regular grids which account for internal contacts with adhesion and are directly transferable to contemporary fabrication techniques the project will be conducted in cooperation with leading experts on multiscale modelling and additive manufacturing from the livmats cluster of excellence university of freiburg germany with an emphasis on future collaboration with and knowledge transfer to the czech republic and slovakia
using singlecell transcriptomics to identify the diatom silica morphogenesis machinery

diatoms are a large group of unicellular eukaryotic microalgae that biosynthesize sio2 silicabased cell walls frustules they are ubiquitously present in aquatic habitats and key primary producers in the oceans contributing 20 of the annual photosynthetic co2 fixation on earth the architectures of frustules are species specific displaying intricate patterns of nano and microscale features and are believed to be of prime importance for the ecological success of diatoms furthermore in biomineralization research diatoms serve as model systems to reveal the mechanisms by which organisms are able to generate inorganic materials with complex architectures such insight holds the promise of gaining advanced capabilities to synthesize minerals with tailored properties using an environmentally benign processes during the past two decades numerous candidate proteins potentially involved in diatom silica biogenesis have been put forward but only a small number of these have been confirmed to be required for this process the diamorphy project aims to identify the complete set of proteins required for silica morphogenesis in the model diatom thalassiosira pseudonana to achieve this the project will inverse the conventional approach by analyzing silica biogenesis in induced morphological mutants of t pseudonana rather than in the wildtype for the first time singlecell transcriptomics will be applied to study gene expression at specific stages during silica biogenesis comparative analysis of the resulting highly refined transcriptomics datasets is expected to crystallize a comprehensive core set of silica morphogenesis genes in proofofprinciple experiments selected proteins from this core set will then be functionally characterized in vivo using stateofthe art genetic engineering techniques
criminal and state governance in the time of the covid19 pandemic evidence from mexico

hundreds of million people live in areas that are controlled by criminal organized groups ocgs suffer from their violent actions and receive governance from both state and criminal actors the recent covid19 pandemic required governance such as the enforcement of containment restrictions to combat its spread notably during the pandemic apart from national governments ocgs engaged in emergency response activities eg delivered aid to people in need or enforced curfews in their controlled territory the role of criminal governance particularly in emergencies is however still largely unknowncovidcrimes fills this research gap and studies the role of ocgs in emergency response during the covid19 pandemic in mexico combining geographical information on the location of ocgs before covid19 with performance measures concerning covid19 containment policies excess mortality and covidrelated death rates covidcrimes estimates the causal effect of the presence of ocgs on the emergency response performance in a monthly panel of mexican municipalities using a fixed effects model in combination with several instrumental variable approaches that account for differences in covid19 exposure and endogeneity concerns related to the location of ocgs by gathering novel digital information on criminal and state governance activities at the local level and analyzing their interrelation and effectiveness covidcrimes will shed light on the mechanisms how ocgs influence emergency response additionally covidcrimes will assess the societal consequences of criminal governance by quantifying to what extent ocgs gained power and local support with their emergency response activities understanding whether and how ocgs act in emergencies and influence emergency response and its consequences is crucial for the design of effective policies to manage crises and for the stability of political institutions a core element of a functioning society that is in any case challenged
assessing the impact of urgent measures in protecting atrisk detainees in latinamerica

urgent measures ums are granted by international human rights hrs bodies to protect persons in a situation of extreme gravityurgency in latin america ums are mostly granted to protect detainees when their right to life integrity andor health are in danger of being violated when a um is granted the state is requested to provide detainees with eg immediate access to medical care drinking water or sanitation in such cases ums may prompt emergency protective actions that can in the most extreme circumstances save the life of the beneficiary of these measures though ums have been issued on thousands of occasions they have attracted little academic attention the few studies that exist focus on a doctrinal analysis on compliance such studies have several shortcomings in that they primarily examine only procedural legal aspects and often excessively rely on information provided by hrs bodies themselves as ums often face practical financial and political constraints that shape and limit their implementation it is crucial to establish a better understanding of how these measures are applied in practice impactum moves beyond the traditional legal research questions and methods of analysing ums it instead proposes an interdisciplinary study of ums that 1 considers the context in which ums are enforced and how they are applied on the ground 2 assesses the impacts of ums on detainees legalinstitutional systems and international actors 3 discusses their strengthslimitations 4 analyses their wider learning effects with reference to ums granted by 4 hrs bodies to protect atrisk detainees in 6 latin american countries impactum will develop a critical normative impact framework useful to provide a deeper theoretical analysis as well as insight into how to formulate ums to maximise their practical protective effects impactum will thus uncover and present new knowledge on emerging issues with ums that are currently unaddressed in academia
identification of novel diagnostic predictive and therapeutic strategies in chronic kidney disease

chronic kidney disease ckd represents an important medical social and economic burden with high morbidity and mortality the prevalence of ckd has reached 10 in the developed world and ckd globally accounts for more years lived with disability than all neoplasms combined therapeutic strategies to treat ckd or tools for risk stratification of patients are limited and the field has produced the fewest translational randomized clinical trials in medicine while diagnosis is still based on invasive tissue biopsies targetckd aims to establish a holistic understanding of cellular and molecular mechanisms that drive disease to develop novel diagnostic predictive and therapeutic options concrete objectives are 1 the development of a platform for identification of novel predictive markers and therapeutic targets in kidney biopsies 2 the identification of conserved spatiotemporal mechanisms and cellular crosstalk events driving ckd 3 the validation of mechanisms and therapeutic targets in human 3d organoid systems and development of therapeutics and 4 the development of a noninvasive diagnostic platform from urine targetckd will utilize a broad interdisciplinary expertise with various novel single cell and spatial genomic and computational technologies combined with transgenic mouse models and cuttingedge in vitro platforms the integration of all these technologies in clinical relevant specimen with follow up data and large independent validation cohorts will allow targetckd to radically transform nephrology towards a better understanding of kidney diseases development of novel diagnostics and risk stratification tools for patient allocation and clinical testing as well as urgently needed therapeutics for patients suffering from ckd the passion that drives this project results from a simple emerging hypothesis it is possible to predict ckd and develop therapeutics by an indepth systems approach utilizing emerging genomic technologies
the viral imaginary between crisis and routine

this action interrogates the social and cultural interpretations and narratives of viruses in asia it focuses specifically on how viruses have been historically narrated interrogating the framings of viruses as routine versus viruses as crisis to examine these framings this action will interrogate the historical layering mobilized in asian popular culture by analyzing these reflections of viruses alongside how people respond to them the action will query how historical parallels are used to narrativize the virus making the virus a knowable entity the overall goal of this action is to elicit the lessons learned from these social and cultural interpretations that can be compared to europe and the world
unlocking the secrets of remote memories dissecting the corticohippocampal engram

every day we form memories based on experience these memories undergo a selective process during which some become longlasting memories while others fade awaymemory age can be distinguished based on the neuronal systems engaged during different stages recently acquired detailed memories rely on the hippocampus especially ca1while remotely acquired more generalised memories depend on cortical activationspecifically the anterior cingulate cortex acc however our understanding of how certain information from the original event is selected to migrate from one region to the other while other is lost remains limitedwe aim to explore whether these two regions attend to different information during memory acquisition to accomplish this we will employ flicre an innovative optogenetic tool that offers precise temporal control over the tagging and manipulation of cells through both calcium signalling and light activation this groundbreaking technology allows us to attain an unprecedented level of temporal precision enabling differential labelling of cells that encode distinct information such as when a mouse is exploring an environment versus experiencing a footshock or freezingby tagging and manipulating these diverse populations in ca1 and acc we will track their recruitment at different time points this investigation seeks to shed light on why memory age influences our perception of the original experience differently by understanding the underlying neuronal mechanisms we may find ways to reverse this effect offering a potential approach to help treat maladaptive memories our research holds promise in unravelling the complexities of consolidation and its implications for memory therapies