Dragon09/odtu_chatbot huggingface dataset:
untying the knot of creep and fatigue behaviour of uhpc for sustainable design of infrastructures enabling the carbon neutrality transition

concrete as the most widely used construction material is responsible for about 7 of global energyrelated co2 emissions addressing this environmental challenge within the construction sector necessitates urgent development and adoption of multibeneficial materials characterized by low carbon emissions superior durability and excellent mechanical properties ultrahighperformance concrete uhpc emerges as such a material offering a 26 reduction in carbon emissions and a 24 cost advantage according to comparative lca and lcc analysis on benchmark structures uhpc is the ideal candidate material for broad application particularly in construction of new and retrofitting existing aging infrastructure subjected to cyclic and sustained actions including bridges tunnel linings wind turbine towers roads and aircraft runwayshowever the lack of knowledge regarding uhpcs longterm performance including creep and fatigue behaviour hinders its widespread use in infrastructure projects the objective of this project is to unlock this critical knowledge gap and develop structural design guidelines aimed at driving the construction sectors transition towards carbon neutrality through the use of highperformance materials that enable us to build better for longer and employing lower material volumes which all imply reduced consumption of raw resources and reduced environmental impacts in the short and long term employing multiscale experimental tests multiphysics and mesoscale numerical methods the project aims to comprehensively characterize and predict uhpcs response to creep and fatigue and the creepfatigue coupled effect cyclic creepincreeguings breakthrough will fill the current knowledge gaps in understanding uhpcs longterm performance this initiative will enhance europes competitiveness in constructing ecofriendly resilient and durable infrastructure by providing practical design tools to expedite their widespread adoption
ethical and privacypreserving big data platform for supporting criminal investigations

this proposal aims to develop an innovative and privacypreserving decisionsupport system for european law enforcement authorities leveraging advanced big data and ai technologies to effectively combat crimes and terrorism the proposed system integrates federated learning user and entity behavior analytics ueba and other big data and ai techniques to monitor social network data deep and shallow web information and police databases in a secure collaborative privacyaware and ethical mannerthe primary objective is to help law enforcement authorities leas fighting cybercrime and terrorism by identifying key communities and users involved in activities such as hate speech child sexual abuse terrorism or drug trafficking and to use this information to better allocate police resources preserve will leverage federated learning a decentralised machine learning approach that allows model training on distributed data sources while preserving data privacy by collaborating with multiple leas across europe preserve will collectively combine social network data deep and shallow web information and police databases to analyse large amounts of spatial and temporal data related to criminal activities to identify patterns and correlations to provide better policeresource management on critical areas
gate2brain towards sme designation and paediatric investigational plan

gate2brain g2b is a biotech company focused on the development of therapeutics that efficiently cross biological barriers such as the bloodbrain barrier bbb using this radically innovative peptidebased patented technology platform g2b has developed a novel therapy g2b002 for pediatric brain tumors such as diffuse intrinsic pontine glioma dipg and glioblastoma currently without a cure or poor prognosis small and mediumsize enterprises smes represent 99 of all business in the eu g2b will apply to obtain sme designation to have access to finance and eu support programs which include research competitiveness and innovation funding another potential benefit that g2b could obtain is the fewer requirements or reduced fees for eu administrative compliance g2b is mainly focused on pediatric brain cancer a rare but mostly lethal central nervous system disease after obtaining sme designation g2b will develop the paediatric investigational plan pip included in the eu paediatric regulation thus g2b expects also to benefit from i reduction of registration taxes ii tax deductions iii access to financial support iv assistance in the drafting of clinical trial protocols v ease of access to procedures to accelerate marketing in europe vi right to marketing exclusivity for 10 years in europe and vii 6month extension patent protection initiative of medicines for childrenthe health economics market access outcomes strategy that g2b will also perform will include a willingnesstopay and productmarket fit analysis between others the final report will help to estimate the economic value of the company considering relevant alternatives for both the healthcare system and pharmaceutical industrythe rd strategy of g2b is focused on the therapeutic validation of its platform to demonstrate its safety and efficacy with sme designation and pip g2b will be able to successfully initiate first in human clinical trials in pediatric population
conceptualising intercultural mediation in the greekroman antiquity a multidisciplinary approach

intercultural mediation is a social practice that creates bonds between individuals or groups from different cultural background through the agency of a third party the agent or mediator can be either an individual or a group of people eg an ambassador a translator a salesman immigrants pilgrims tourists and so on whose activity often unintentionally reinforces international relationships and fosters social cohesion especially for what concerns culturally distant andor hostile groups the practice exists from ancient times prompt by various political and economic factors and the understanding how and why it occurred and why it succeeded or failed in the past can greatly impact the studies related to intercultural exchange by amplifying our understanding of social mechanisms that may promote cultural tolerance and manage conflicts however current studies related to multicultural coexistence overlook this issue and the research is further impeded by the lack of a universal theory on mediation or a valid methodology of its study the cima project aims to fill this gap by studying a reallife phenomenon in a historical perspective in order to enable the use of past sociocultural experiences to address current social issues namely cima will examine a series of case studies that emphasize the activity of the ancient greeks as diplomatic mediators trading agents andor transmitters of concepts and ideas between foreign communities statestribes and will develop an adaptable model of analysis of this phenomenon applicable in various disciplines and fields inthis manner the project will transcend the conventional boundaries between disciplines and open new interdisciplinary directions for future research the outputs of the project will be disseminated both in written form in journals conference proceedings and social media and as oral presentations targeting researchers students and the general public
multiattribute values ontologies to improve built heritage information assessment in clustered territories

moebhios multiattribute values ontologies to improve built heritage information assessment in clustered territories aim is to develop an innovative valuebased decisionmaking approach on historical built heritage on the crossborder contexts of clustered territories the improvement of information systems for territorial geomapping with multiattributes values from social sciences fields will be pursued developing advanced information ontologies specifically suited for landscape and built heritagethe project is tested on the pilot case study of historical built heritage in palestine assuming a key example of complex heritage ecosystem at the territorial scale envying societal and landscape developing programs similar to other contexts at european bordersto achieve the goal the research project provides a path of theoretical studies onfield direct training and practical activities social surveys technical dialogue sessions for the collection of data concepts and logical structures referring to 4 main macroareas concerning built heritage analysis social archaeological economic and cultural fields the researcher will participate to a creative research training program across europe and middle east in contact with excellent research laboratories and chairs in cultural heritage social palestine and economic germany fields the researcher will reintegrate the advanced social sciences skills to architectural and built heritage research considering the horizon of digital practices of documentation and 3d modelling experimented at the beneficiary sending institution italy the scientific quality of resulting information ontologies for historical built heritage is envisaged by development agencies for territorial governance and the strengthen of local communities in third countries fostering the establishment of goodpractices and standard protocols on dynamic representation and monitoring of tangible heritage through eu and above
synergizing enhanced radiotherapy with tumorassociated macrophagestargeted immunotherapy in glioblastoma with multimodal therapeutic nanoparticles

in glioblastoma gbm intrinsic and environmental factors are limiting the efficacy of radiation therapy rt and immunotherapy these factors include intrinsic cancer cells resistance hypoxia and the presence of immunosuppressive cells such as tumorassociated macrophages tamsconsidering these current limitations for rt efficacy and the specific deleterious role of tams in gbm i designed an original therapeutic strategy combining enhanced rt and tams reprogramming with tolllike receptors tlrs agonists to synergize direct cytotoxicity to tumors cells at low radiation doses with immunotherapy for both local and recurrent tumor rejection for this i will use relevant radiosensitizing moieties for gbm high z atoms which can efficiently absorb scatter and emit radiation energy and catalase an enzyme capable of converting h2o2 to oxygen in the tumor microenvironment tme it will be simultaneously applied with the combination of the tlrs agonists polyic and resiquimod which will be used to reeducate tams and prepare the tme to a strong antitumoral immune response the selected molecules will be incorporated in a new multimodal therapeutic nanoparticle mtnp based on a nanosized zeolite structure allowing to combine the two approaches in a unique particlethe mtnps will be tested in vitro and in vivo in murine model of gbm and patientderived samples to verify their effectiveness in enhancing rt and reeducating tams and their effect on tumor growth the present multidisciplinary research program aims at supporting greater progress in the treatment of brain tumors and ultimately leading to improved outcomes for cancer patients
digital technologies acting as a gatekeeper to information and data flows

tango will establish a stronger crosssector data sharing in a citizencentric secure and trustworthy manner by developing innovative solutions while addressing environmental degradation and climate change challenges the overall outcome is a novel platform exhibiting the following capabilities userfriendly secure trustworthy compliant fair transparent accountable and environmentally sustainable data management having at its core technology components for distributed privacy preserving and environmentally sustainable data collection processing analysis sharing and storage this platform will promote trustworthy and digitally enabled interactions across society for people as well as for businesses tango will leverage the power of emerging digital technologies to strengthen the privacy for citizens and privatepublic organisations reduce costs and improve productivity it will unlock the innovation potential of digital technologies for decentralised privacypreserving applications while making accessible and demonstrating this potential within the gaiax and eosc ecosystem with 37 key partners from 13 countries tango is uniquely positioned to provide a high impact solution within the transport ecommerce finance public administration tourism and industrial domains supporting numerous beneficiaries across europethrough the provision of tango technologies a trustworthy environment will be designed acting as a gatekeeper to information and data flows citizens and publicprivate organisations will be empowered to act and interact providing data both online and offline tango will focus its activities on 3 main pillars i the deployment of trustworthy accountable and privacypreserving datasharing technologies and platforms ii the creation of data governance models and frameworks iii the improvement of data availability quality and interoperability both in domainspecific settings and across sectors
earlystage organocatalysis

organocatalysis has drastically advanced stereoselective chemical synthesis from an underdeveloped niche area it has become the most frequently applied approach to asymmetric synthesis organocatalysis is also developing into a technology which can be used to make pharmaceuticals scents and other fine chemicals however the early stages of industrial chemistry the upgrading of hydrocarbonbased alkenes arenes and alkanes are still largely dominated by heterogeneous and transition metal catalysts here we will address the question if a selective earlystage organocatalysis eso can be developed that directly delivers highvalue substances from abundantly available hydrocarbon feedstock chemicals while significantly saving energy and other resources during the last few years we have developed confined organic acids as a new catalyst class that features enzyme and zeoliteinspired active sites with welldefined pockets for selective substrate recognition and catalysis these catalysts offer a widely tunable reactivity range reaching extreme levels with turnover numbers exceeding 106 in challenging asymmetric carboncarbon bond forming reactions and approaching magic acid reactivity toward the activation of olefins we now aim to take confined acid catalysis to another level by designing new even more reactive acids that enable the utilization and valorization of steamcrackerbased hydrocarbons in selective organocatalysis specifically we propose three aims 1 developing asymmetric olefin hydrofunctionalizations including hydrations and hydroarylations 2 an early stage functionalization of simple arenes such as benzene and toluene via highly stereoselective and regioselective electrophilic aromatic substitution reactions and as the ultimate test of extreme reactivity 3 we propose organocatalytic asymmetric reactions of alkanes the allunderlying goal will be the design and development of organocatalysts of the next generation
making migration and migration policy decisions amidst societal transformations

paces offers a groundbreaking approach to studying and understanding peoples decisions to migrate and explores how this knowledge can better inform migration policies paces focuses on two parallel research components the factors shaping migration decisionmaking and the mechanisms underpinning migration policies synthesizing theoretical and empirical knowledge from a broad array of academic disciplines and methodological paradigms the project systematically investigates the interactions between migration decisions migration policies and broader social transformation as manifested in interconnected processes of economic political demographic technological and cultural change based on a theoretical synthesis and qualitative and quantitative data collected in algeria ethiopia italy tunisia niger slovakia and spain paces will elaborate a heuristic model that identifies different constellations of conditions that shape decisions to stay and migrate at different stages of individual life trajectories and migrant journeys in addition by adopting a theories of change approach paces will systematically investigate identify and track the assumptions on migration decisions used by policymakers to formulate policy designs and objectives by exploring the evolution of eu and national policies towards labour and family migration paces investigates the extent to which current migration policies are evidencebased and areas where policies will benefit from valuable insights provided by migration decisionmaking research by doing so paces seeks to contribute to elaborating more effective models of eu migration governance that also account for the uncertainties of future social transformations supported by an interdisciplinary consortium of experienced partners paces engages in coparticipatory research with policymakers stakeholders citizens and migrants to generate maximum scientific political and social impact
digitising smell from natural statistics of olfactory perceptual space to digital transmission of odors

this proposal is framed by a technological goal we aim to digitize smell achieving this is currently prevented by gaps in basic science we aim to fill these gaps culminating in a proof of concept for our model the primary gap we identify is lack of data on what humans typically smell phrased conceptually in aim 1 we ask what are the natural statistics of human olfactory perceptual space we address this in a series of three experiments highlighted by one where we equip participants with a wearable sampling apparatus we designed and built for this proposal the apparatus measures sniffing behaviour to identify odor sampling measures neural activity to verify olfactory perception takes video of the visual scene analyses total levels of volatile organic compounds in real time and collects odor samples for detailed analysis off line in other words we generate an olfactory equivalent of google street view with the addition of chemical perceptual and neural data using this we will characterise the natural statistics of human olfactory perceptual space moreover a major contribution of this proposal will be in posting this massive data as a publicly available recourse next in aim 2 we will use this data to digitize human olfactory perceptual space we build on a model that allows us to recreate odors using a restricted set of odor primaries we will test our model in two frameworks one we call smellovision where we develop the algorithmic framework to generate an odor to match any digital image and one we call tellesmell where we develop a device to sense the environment the algorithmic framework to transfer the data and a device to generate the corresponding odor remotely we provide pilot data for aim 2 where we sensed an odor in mainz germany transmitted the data over ip to rehovot israel where we successfully recreated the smell this was as far as we know the first transmission of odor over ip
triad enhancing synergism on telomere function in health and disease

over the years the eu investments ie erdf and rrf have played a crucial role in advancing biomedical research in underperforming eu member states however in competitive research fields erdfrrffunded labs face significant challenges including mismatches between regional and european approaches disparities between horizon thematic priorities and nationalregional smart specialization strategies as well as variations in funding allocation between consortia and single beneficiaries the absence of coherent internationalization strategies limited training programs and skilled personnel fragmented research endeavors and funding constraints further hinder the development of sustainable research synergies with leading research institutes to address this pressing need we propose triad a program utilizing the upstream synergy model under pathway a to enhance collaboration among three erdffunded labs in greece portugal and the czech republic with a scientific focus on the functional role of telomeres in health and disease leveraging erdf funding the three research teams have developed complementary expertise in research tools platforms and approaches at a regional level the core objective of triad is to enable the individual erdf beneficiaries to overcome isolation through crossborder collaboration and successful participation in horizon europe calls this will be achieved through a comprehensive collaborative strategy to share methodologies an extensive human resources development plan a set of activities to enhance innovation capacity and improve access to european ri networks as well as to increase competitiveness in research funding and establish effective management and administrative structures on site we anticipate that this strategy will establish a lasting legacy benefiting erdf beneficiaries and the wider community by fostering a collaborative ecosystem that will extend well beyond the projects duration
social economy for resilience inclusion and good life in rural areas

european rural areas face societal demographic economic and environmental pressures due to global transformations and crises they are in need of a renewal by social innovation that increases their resilience and reduces the adverse effects on their socioeconomic and environmental sustainability unbalanced development impacts their populations livelyhoods and wellbeing in general but it affects the most those people who are already in precarious and fragile positions serigo produces evidencebased theoretical and practicable knowledge on how the social and solidarity economy sse can support resilience social inclusion and good life in european rural areas based on the research results produced the aim is also to provide insights and recommendations on what framework conditions and policy arrangements are necessary to promote this as well as to trigger constructive debates and collaborations around this issue involving diverse set of stakeholders in europethe project applies an intersectional perspective to vulnerability as well as implements critical systems thinking in combination with communitybased participatory research to investigate potentials of the social economy in promoting social inclusion and in enhancing the quality and accessibility of services in rural areas empirical data is gathered in a high number of qualitative case studies from 13 countries on social economy solutions implemented in local contexts using the multiactor approach serigo benefits from more nuanced and live insights into the drivers of social exclusion offered through the lenses of local stakeholders working together with researchers on cocreated experimental pilots in five european regions serigo ensures also with a system of deliberate feedback loops dedicated multilevel policy workshops and a sustained thematic community of practice that the new knowledge generated is pertinent and applicable and all its outputs have high exploitable potential