Dragon09/odtu_chatbot huggingface dataset:
using deep neural networks to understand functional specialization in the human visual cortex

over the last few decades neuroscientists have identified multiple brain regions that perform distinct often highly specialized functions such as processing faces understanding language and even thinking about what other people are thinking despite our increased understanding of the computations performed in these regions the precise causes and origins of functional specialization in the brain are still a mystery and not accessible to direct experimental approacheshere we propose to combine cuttingedge computational modelling largescale sampling of naturalistic behaviour and human neuroimaging to overcome these limitations focusing on visual perception we will exploit the latest advances in artificial neural networks to probe three critical aspects of functional specialization in the ventral visual pathway first by training networks on natural and artificial visual categories and identifying which features result in functional specialization we will characterize what it is about a visual category that leads to functional specialization second we will leverage largescale egocentric datasets of infant and adult visual input to test how visual experience and natural input statistics shape functional specialization during development third we will ask why certain neural features become specialized for highlevel visual categories in the human visual cortex in the first place critically for each of these aspects we will close the loop and directly test and validate its predictions in the human brainour project will shed light on functional specialization from a new angle by relating functional specialization to the computational constraints of performing tasks in the real world using this novel approach our project tackles some of the most fundamental questions about the functional organization of the human mind and brain the what how and why of functional specialization
batteries europe secretariat

batteries europe secretariat best proposal aims to enrich strengthen and extend the key role of batteries europe by gathering academia industry and research expertise within the secretariat to consolidate the battery ri community and assist the existing platform in the achievement of their ambitious goals best consortium will engage in its experts working groups industry stakeholders academia policy makers researchers and citizens from all the value chain especially broadening involvement on underrepresented domains and countries best will contribute to gain synergies among battery ri stakeholders landscape consolidate the workflow among the initiatives facilitate free and inclusive access to information strength industryresearch collaboration to push technology developments to reduce time to market of new solutions reinforce european talent attraction capacity and provide factbased orientations to policy makers the secretariat will gather expertise to develop strategic ri agenda design updated roadmaps establish kpis per application transport stationary portable etc to nurture the set plan contribute to standards and reporting methodologies harmonization promote education on battery fields and rise social awareness the secretariat will organize workshops per objectives complemented with experts interviews discussion forums scientific papers review etc to confront current state of the art with future trends considering international tendenciesbest is formed by 11 partners and 4 affiliated entities led by innonergy with zabala clerens sintef vdivde innovation cicenergigune instm unimib unipv polito eera ease and enea the partners are promoters of main european initiatives related to batteries that has facilitated the establishment of collaboration flows to bring batteries europe platform to next stage in 36 months with a budget of 2999889
investigation on the vaccination potential of il4i1 deficient dendritic cells in chronic lymphocytic leukemia

chronic lymphocytic leukemia is a common leukemia in adults characterized by an extremely immune suppressive microenvironment which leads to the failure of otherwise effective immunotherapy regimens including dendritic cell dc based tumor vaccines recent attempts to understand immune suppression in cll provided substantial evidence and identified that overexpression of amino acid catabolizing enzyme interleukin4induced 1 il4i1 in cll and immune cells as key phenomenon in cll mediated immune suppression il4i1 is secreted by dcs in the immune synapse and downregulates cd8 t cell effector functions while presenting antigens which perfectly explains failure of dc vaccines in cll treatment addressing this the important objectives of the present project are 1 to investigate the negative impacts of il4i1 on dc functions which are in particular relevance to dc vaccines and 2 to analyze the potential of il4i1 deficient dcs in cll vaccination in this project i will first study ex vivo the dc and cd8 t cell dysfunctions associated with dc secreted il4i1 by assessing antigen presentation immune synapse formation cd8 t cell activation and proliferation using both model antigen siinfekl and whole cll cell antigens next i will feed il4i1 deficient dcs with whole cll cell antigens and study using cuttingedge techniques their potential in eliciting anticll immune responses in vivo using etcl1 adaptively transferred cll mouse model tcl1ati obtained my phd in 2021 and presently working as research associate at the department of biochemistry and molecular biology university of szeged hungary i propose this project for marie curie postdoctoral fellowship european fellowships this project will be carried out in the division of molecular genetics german cancer research center deutsches krebsforschungszentrum dkfz heidelberg germany under the supervision of dr martina seiffert
processinginmemory architectures and programming libraries for bioinformatics algorithms

low cost high throughput dna and rna sequencing hts data is now the main workforce for various genomics and transcriptomics applications hts technologies have already started to impact a broad range of research and clinical use for the life sciences these include but are not limited to 1 largescale sequencing studies for population genomics and diseasecausing mutation discovery including cancer 2 metagenomics 3 comparative genomics 5 transcriptome profiling and 6 outbreak detection and tracking including covid19 ebola and zika hts also impacts the whole health care system in several directions although there is still much room for improvement sequencing of personal genomes is now becoming a part of preventive and personalized medicine as hts technologies make it possible to 1 identify genetic mutations that enable rare disease diagnosis 2 determine cancer subtypes therefore guiding treatment options and 3 characterize infections and antibiotic resistance currently all genomics data are processed in energyhungry computer clusters and data centers which also necessitate the transfer of data via the internet which also consumes substantial amounts of energy and wastes valuable time therefore there is a need for fast energyefficient and costefficient technologies that enable all forms of genomics research without requiring data centers and cloud platforms in this project we aim to leverage the emerging processinginmemory pim technologies to enable such powerful edge computing we will focus on codesigning algorithms and data structures commonly used in bioinformatics together with several types of pim architectures to obtain the highest benefit in cost energy and time savings biopim will also impact other fields that employ similar algorithms our designs and algorithms will not be limited to cheap hardware and they will impact computation efficiency on all forms of computing environments including cloud platforms
the spectrum of fluctuations in living matter

living matter is active it is driven far from thermodynamic equilibrium by irreversible microscopic processes such as the action of molecular motors and cell division this microscopic activity generates nonequilibrium fluctuations which overwhelm thermal noise and impact biological processes across scales from intracellular transport to tumour formation however unlike in the case of thermal fluctuations we have no theoretical framework like the fluctuationdissipation theorem to predict the statistical properties of active fluctuations here i propose to address this knowledge gap by means of theoretical research combined with experimental collaborations organized in two aimsin the first aim at the subcellular scale we will predict the spectrum of active noise based on the nonequilibrium binding kinetics of cytoskeletal proteins to this end we will coarsegrain a cytoskeletal network model in which detailed balance is explicitly broken at the molecular scale we will then use the predictions to analyse experimental data and infer features of molecular activity in living cells and in the mitotic spindlein the second aim at the tissue scale we will predict the statistical properties of active pressure fluctuations due to stochastic cell proliferation which is itself regulated by pressure we will establish how this mechanical feedback affects the spectrum of the pressure field in a growing tissue to this end we will generalize tools from the renormalization group that were originally developed to study nonequilibrium critical phenomena through the kardarparisizhang equation we will then collaborate with experimentalists to test our predictions by measuring the spectrum of pressure fluctuations in living tissues for the first timeoverall this research will lay the basis of a stochastic hydrodynamics of living materials and at the same time reveal how active fluctuations promote biological functions in cells and tissues
novel ecocementitious materials and components for durable competitive and bioinspired offshore floating pv substructures

the green transition strategy of the eu aims to a climate neutral economy by increasing the use of renewable energy sources being offshore floating photovoltaics pv one of the target technologies although floating pv is already used in shallow inland waters its use in offshore environments is not common due to the harsh marine conditions and thus requires a revamping of the technology the main objective of naturseapv is to improve the overall lifetime reliability and maintainability of marine substructures for offshore floating pvs and thus reduce its lcoe for this naturseapv will develop innovative structural designs capable of handling the marine conditions at the same time ensuring the durability and minimizing uninstallation costs the substructures will be built using newly developed environmentally friendly low carbon ultra high performance concrete and will be coated with new biobased antifouling and anticorrosive coatings a specific predictive simulation toolkit will be developed to assess the mechanical and chemical durability of the new materials under marine conditions and will be validated against experimental data the new materials and structural design will be first validated in the laboratory testing then integrated in prototypes to check the buildability and to be validated in relevant environments naturseapv will codevelop and covalidate the project results with external stakeholders while assessing the potential environmental and social impacts and perception to verify that the proposed solutions compatible with existing regulations and socioeconomic activities taking part in the sea to maximize the impact of offshore floatingpv solutions the results and knowledge from the project will be managed to have the most effective exploitation eg ip and widest possible communication and dissemination to forward the implementation of successful floating pv substructures with circular materials and low competitive lcoe
rethinking emergency from a legal historical perspective contexts actors practices 19142020

rule of law and human rights are under pressure worldwide the political and legal landscape is dramatically changing with situations of crisis becoming a recurrent presence in the life of our polities we thus witness a resurgence of emergency legislation and measures that states employ to tackle the nefarious effects caused by numerous disruptions from financial instability to terrorist activity pandemics or military threat traditionally emergency has been understood as a mechanism that has only temporary and limited effects on legal systems once the crisis recedes fundamental rights and constitutional process are restored emerge argues that emergency has longlasting effects subsisting the crisis they affect our understanding of human rights the rule of law principle and constitutional practices emerge will advance a paradigmatic shift in the study of emergency by offering an original reevaluation of the impact emergency has on the operation of the law it will provide a muchneeded legal historical explanation of how the historical experience of emergency has shaped constitutional and political cultures across europe in the past century delivering a chronological examination and a timeline of the practice of emergency in relation to economic social and political crises it will critically reevaluate key moments in european constitutional history from 1914 to 2020 emerge will offer a comprehensive analysis of emergency by forging a unique multidisciplinary approach drawing on comparative legal history contextual legal history legal theory law in action law in context narrative jurisprudence and digital humanities similarity network and sentiment analysis rather than focusing exclusively on legal rules it will study the agency of individuals actors and subjects of emergency legislation and reconfigure emergency as a multilayered sociolegal phenomenon involving social actors and political choices shaping constitutional cultures
collaborative innovation in 3d vlsi reliability

the overarching goal of coin3d is to foster strategic networking and knowledge exchange between uth and leading european research institutions to enhance research management and commercialization capacities in the area of 253d chiplet architectures to achieve this objective the project will establish strong partnerships with european counterparts and create a space for collaborative learning and experience sharing additionally the project will develop tailored training programs and resources to equip uth researchers and administrative staff with the necessary skills for effective research management and successful commercialization endeavours the main target of the coin3d project is to enhance the research capacity of an entity being active in a widening country with the assistance of more developed countries trying to expose the pathways for innovation and research excellence through these initiatives the project aims to elevate uths research profile stimulate innovation and contribute to the institutions strategic positioning within the global research community in addition our vision aligns seamlessly with the objectives of the european chips act as we work towards cultivating a vibrant ecosystem for semiconductor research development and commercialization a wide number of twinning activities are foreseen and a strong interaction plan is already in place together with core research activities that can be beneficial for the entire consortium our core research plan is moving around one of the most significant research directions in the area of 253d vlsi systems reliability ie the provision of novel eda reliability tools for 3d vlsi designs through the integration of innovative algorithms for physicallevel and systemlevel reliability assessment optimizing power delivery networks and modelling aging phenomena thereby advancing the stateoftheart in semiconductor system design and ensuring longterm reliability
lomustine with or without reirradiation for first progression of glioblastoma a pragmatic randomized phase iii study

recurrent glioblastoma is an invariably fatal refractory cancer with dismal prognosis patients suffer from low quality of life and very burdensome symptoms this project is proposing an investigatorinitiated phase iii randomised pragmatic clinical trial we will assess whether the addition of radiation treatment to lomustine chemotherapy has superior efficacy as compared to lomustine chemotherapy alone for treatment of patients with recurrent glioblastoma the study will apply minimal patient eligibility criteria and thus be as close as possible to the routine clinical setting costeffectiveness analysis will be performed to investigate the economic value of adding radiation treatment to lomustine chemotherapy in different countries to support evidenceinformed policy decisions if successful the outcomes of the project will define a new evidencebased standard of care for recurrent glioblastoma the proposed research could lead to improved patient survival and quality of life but also improving health system sustainability this is a multidisciplinary and multistakeholder consortium involving clinical oncologists radiation oncologists health economists and patient representatives the study design was successfully discussed with patients this action is part of the cancer mission cluster of projects on diagnosis and treatment
integrated models for the development and assessment of high impact chemicals and materials

safe and sustainable by design ssbd chemicals and materials are crucial to address the challenges of modern society however lack of stakeholders coordination limited access to relevant data and absence of standardised methods have thus far hampered the emergence of a comprehensive approach to ssbd insight will overcome these challenges by developing an innovative framework for mechanistic impact assessment of chemicalsmaterials the insight framework will consist of a multilayered approach that integrates data models and impact outcome pathway iop graphs insight will also provide curated and userfriendly fair data and computational modelsworkflows insight aims to foster a paradigm shift in the assessment of sustainability and safety of chemicals and materials from a fragmented situation to a holistic and integrated approach insight will provide decision maps as a part of its integrated framework to guide users through the decisionmaking process aiding them in evaluating the social economic health and environmental impacts of chemicalsmaterials in a more efficient and comprehensive mannerthe insight project is fully aligned with the eu principles of safety and sustainability and the european green deal insight will support the development of policies in the areas of neutrality biodiversity protection public health and circular economy thus aiding the development of a dynamic economy respecting planet earth as a whole avoiding harm to humans and the environmentby democratising the use of cuttingedge ai methods to ssbd insight will drive innovation towards a digital circular climateneutral and sustainable economy insight will help the industry to optimise development and production of chemicalsmaterials and derived products support regulators and policymakers in informed decisionmaking towards safer and more sustainable society and pave the way for a comprehensive approach to ssbd
biodiversity local knowledge and zoonoses in austronesia ethnography of bats and related interspecific communities

the proposed research lies at the juncture of the anthropology of nature the cultures of austronesia and the study of interspecific relationships considering that a fundamental link exists between biodiversity and the health of individuals populations species and ecosystems and that microbes bacteria and viruses are key to the evolution of civilisations and living beings we will address two questions 1 in a world going through a livestock revolution to what extent can local and scientific knowledge jointly inspire efforts to preserve biodiversity and biosafety and rebuild sustainable relationships with living beings 2 to what extent and on what conditions can humans have contact with bats and coexist with them and other animals incriminated in the spread of zoonoses either as reservoirs or as intermediate hosts conversely at what point do these species endanger human communities we wish to answer those questions through research within several indigenous groups who have lived for millennia in contact with such animals specifically we will conduct ethnographic research at several sites across the large cultural and linguistic region of austronesia which coincides with the range of flying foxes also known as fruit bats to see how different interspecific communities interact and how narratives of vulnerability and immunity operate the project aim is to document and understand how certain peoples maintain relationships with bats and see them and their worlds in the sense used by the biologist von uexküll and the extent to which such knowledge helps them live safely with these animals the general hypothesis is as follows knowing that fruit bats are one of the links in the transmission of zoonotic diseases to humans and also a part of the ecosystem used for food and trade we hypothesise that local practices have led people to maximise use of this resource while developing measures to prevent epidemics
science odyssey research missions under starry skies

science odyssey brings researchers night to six major greek cities in 20242025 its goal is to make science more accessible promote interaction between researchers and the public and highlight the important role of science in our societythe night events will feature engaging exhibitions interactive experiments dedicated spaces for eu missions projects and exciting scientific demonstrations along with a variety of fun learning activitiesunder the researchers at schools initiative researchers will connect with students in classrooms fostering a dynamic exchange of knowledge and ideasalso in line with the projects commitment to inclusivity several innovative activities have been planned such as the chat lab and the find me a mentor initiatives that will facilitate virtual interactions between researchers and students in remote or underserved communities thereby bridging geographical and social divides the digital comic drawing science equality is another initiative to promote inclusivity by tackling gender disparities in science and promoting a more equitable scientific communityresearchers will be given numerous opportunities to showcase their work and further develop their science communication abilities additionally the project will provide them with a masterclass in science communication equipping them with the necessary skills to effectively engage with the publicthe project aims to reach millions of greeks and expects an annual participation of 28000 individuals in the night events to do so it will use digital platforms like social media and podcasts to expand its reach and engage diverse audiences especially young teenagers and parentsby the end science odyssey aims to have a lasting impact on the general public youth researchers participating organisations and the eu by advancing science literacy encouraging stem vocations and fostering an appreciation for research that shapes our collective future