Dragon09/odtu_chatbot huggingface dataset:
acceleration of photocatalytic green hydrogen production to market readiness through valueadded oxidation products

with rising anthropogenic co2 emissions resulting in climate change solutions to rapidly bring green hydrogen to market are required ph2otogen aims to build a scalable photocatalytic flow reactor for green hydrogen production with parallel production of valueadded oxidation products which will contribute to the revenues of the overall system the ph2otogen consortium will use advanced characterisation techniques to determine promising and novel combinations of semiconducting materials to achieving an average solartohydrogen efficiency of 5 over 500 hours in a 500 cm2 demonstrator
blood in the theater gladiatorial and other associated spectacles in roman and late antique greece

the aim of this project is an analytical study of one of the most spectacular kinds of roman cultural performance namely the gladiatorial games and other associated spectacles in the eastern mediterranean the candidate will use the geographical area of modern greece as a casestudy and will approach the phenomenon of the presence of these new for the greekspeaking east spectacles from the point of view of the economic and the cultural dynamics during the roman period in the cities of this areathe project will address three particular subjects a the geographical and chronological distribution of these spectacles in relation to the total number of cities that were active during the roman period in the area of modern greece b the type of venues in which these shows were staged and c the transformations that the gladiatorial and associated spectacles underwent from the late 3rd to the 6th centuries ce intention of the candidate is to conduct a synthetic research embracing all the available sources of historical information literary sources epigraphic evidence and archaeological data the results of which will be quantified and visualized ultimate scope of the project is to push forward the knowledge concerning issues of roman economy imperialism cultural influence and identitythe project will be led by dr michail karambinis under the supervision of dr athanasios vionis associate professor 2009today and director of the archaeological research unit at the university of cyprus 2020today dr karambinis is familiar with the historical and archaeological context of modern greece and he has a published record concerning the two basic axes of the project the urban systems and the gladiatorial spectacles in roman greece dr vionis has worked extensively on late antique and byzantine urbanism rural landscapes material culture and daily life
accelerating local innovation ecosystems in europe

europe has been in the forefront for research and innovation even though at different paces depending on specific location in this context accelero accelerating local innovation ecosystems in europe aims at contributing to reverse the unbalanced business activity in europe by increasing the attractiveness of less advanced ecosystems making modest and moderate innovation ecosystems more attractive to local startups that will benefit from a strong local support and avoid relocation to eu hubs as well to international companies interested in setting up their businesses outside the established and wellknown centres it also aims at tapping into the potential of local ecosystems through codesigned programmes of activities proposed jointly by business acceleration entities located in less connected innovation ecosystems modest and moderate and innovation hubs strong innovators and innovation leaders to improve the quality of business acceleration services their network outreach and scaleup support accelero has the ambition of creating a paneuropean community of business support organisations bsos as the onestop shop for all bsos and its customers the startups and smes as well as for peertopeer exchange networking and connectedness for all stakeholders engaged in the broader innovation ecosystem this will be achieved with an initial accelero extended community apart from consortium members to cocreate and pilottest highquality business acceleration services with european bsos from emerging and moderate innovators together with experts from strong and leader innovation regions or member states followed by the launch of the community inside euroquity platform
high gains high risks for whom a holistic approach to the inequalities of working while studying trajectories grow

across europe 11 million university students 80 combine their studies with paid employment a highly relevant question therefore is how students lives are affected by student employment in the long run yet existing segmented research has failed to provide a comprehensive approach to assess the implications of student employment for students later in life it has remained unclear who gains and risks when working while studying and under which conditions grow will break with these previous conventional approaches by taking on a holistic approach which will jointly analyse the positive and negative effects of student employment for educational and labour market outcomes grow will bridge segmented theoretical views from psychology sociology and labour economics by implementing a life course approach creating a more comprehensive nuanced and interdisciplinary understanding about the implications of student employment for students lives to do so it uses multichannel sequence analysis and mixture hidden markov modelling to jointly analyse educational and labour market trajectories based on highquality longitudinal data from four carefully selected european countries belonging to three different welfare states liberal uk conservative the netherlands germany and social democrat finland it emphasises gender and social origin differences in patterns and implications of student employment as well as differences across students fields of study and national contexts the project includes an ambitious dissemination and communication plan targeting academic scholars policy makers managers of european higher education and higher education students as such the grow project aims at strengthening the social dimension of the european higher education area and contributes to the un sustainable development goals 4 quality education and 10 reduce inequality
isolation of bacteria and extracellular vesicles from body fluids for improved diagnostics

this project aims to deliver a microfluidic platform capable of isolating bacteria and extracellular vesicles evs at high throughput and high recovery rates from clinical samples and perform the necessary downstream analysis for the diagnosis of diseases requiring earlierurgent treatment currently long incubation steps required for identification and susceptibility testing of pathogens make clinicians to prescribe broadspectrum antibiotic treatments in sepsis cases upon hospital admission and in nearly half of cases this treatment fails on a different timescale the lack of symptoms until late stages of some cancer types such as pancreatic cancer means a high mortality rate profiling molecules contained in evs most importantly dna rna proteins and lipids promises a powerful diagnostic tool as biomarkers for cancer but current ev isolation methods relying on ultracentrifugation are lengthy and can potentially damage the information enclosed microfluidics could provide a high yield high throughput solution for isolation and enrichment of such particles however current approaches do not meet requirements of throughput andor detection limit and lack insightful physical understanding i propose to use novel fluid dynamic and electrokinetic models for particle manipulation in microfluidics with stateoftheart fabrication methods to deliver a device capable of rapidly isolating and enriching samples containing a bacteria at low concentration few hundreds per ml to be integrated in a platform with the potential to identify and perform asts in possible bacterial infections in body fluids that avoid culture steps in current gold standards and potentially allow a tenfold time reduction from sample to answer b evs to replace current ultracentrifugation methods thus a future clinical implementation of the project outcomes will have large economic and societal impact
strengthening regulatory capacities for clinical trials oversight in southern africa southsouth and southnorth collaboration initiative for regulatory bodies

the southern africa regulatory for clinical research search is a consortium established in 2020 under the second program of the edctp designed to develop and promote a framework for collaboration harmonization process and support regulatory capacity and develop technical expertise in southern african countries to support the conduct of clinical trials ct it is composed of four institutions from southern africa and one european in this proposal search ii eight institutions come together to strengthen and increase the capacities for the clinical trials review process in southern africa built from the search i project including the issuance of relevant permits ct oversight and clinical research pharmacovigilance and posttrial market authorisation by nras however insufficient access to quality safe efficacious and affordable medical products in southern africa has imposed significant challenges on public health for decades this in part is attributed to weakness or absence of technical expertise lack of policies guidelines and regulatory systems a lack of competent regulatory professionals in the national medicines regulatory authority nmras and ineffective regional collaborations among the nras and necs in response to these regulatory challenges the search i project initiated a process of regional harmonisation efforts and conducted swot analysis among the southern african members and developed a comprehensive common plan for continuous improvement and overcoming gaps at the beneficiary country level and effective harmonization of regulatory and ethical review processes the search ii project aims to support the national regulatory capacity system develop technical expertise and continue promoting the southsouth and northsouth collaboration built from the search i project while also enhancing and advocating the establishment and structuring of nras and necs in botswana eswatini lesotho mozambique namibia and zambia
rhemediation responsive hub for long term governance to destress the mediterranean sea from chemical pollution

the rhemediation lighthouse aims at establishing a responsive hub deploying longterm governance centred on the mission to destress the mediterranean sea from chemical pollution including peak concentrations in known hot spots in particular the most impacting components that currently affect mediterranean resources and threaten its survival in the short term if no action is taken like heavy metals pesticides and pfas forever chemicals should be stopped and removed from the fresh and waste waters before they enter the sea the rhemediation hub governance at the base of this transformation will a deploy chemical pollution remediation technologies based on microalgae solutions to enhance relevant trl when integrated in existing water wastewater treatment systems practises and assessed in their benefits with the involvement of the local communities
geneedited t cells combating iga nephropathy a blueprint approach for safe efficient genome editing of t cells to sustainably combat several immune diseases and cancers related to bcell pathology

there is an increasing prevalence of chronic diseases caused by undesired immune reactions 10 with high burden for the both patients chronicity organ failure early death decreased qol and society eu100 bn a direct health costs as current therapies are limited in efficacy and do not reshape sustainably the disturbed immune balance our ultimative goal is to develop a safe and efficient cell therapy based on genomeedited t cells with redirected specificity to sustainably combat iga nephropathy igan the most common glomerulonephritis and one of the most common causes of endstage renal disease with unmet medical need our specific cell therapy approach is also suitable for other diseases with selective bcell pathogenesis such as iga myeloma iga related celiac disease and rheumatoid arthritis but as a blueprint also for diseases of other ig classes eg igg4 our novel concept offers a specific form of immunosuppression via igsubclass targeting glycosylation targeting with redirected t cells in autoimmune diseases methodically we benchmark three promising genome editing technologies develop new standards for safety assessment and preclinical performance evaluation at the end we will have a lead candidate of a new living drug product envisioned as a onetime treatment for igan and other igaassociated that will be ready to enter clinical fih trials entry into trl6 in addition genetiga delivers enabling technology toolboxes with exploitation options beyond of the core project they might derisk and accelerate the development of nextgeneration gene and cell products in general the project has thus besides its scientific value a high impact not only on the affected patients with igan and related immune diseases but also for the european society by reducing the health economic burden caused by progressive chronic kidney disease as well as by triggering innovation and business options in europes biotech and pharma field
spectrally stable and highperformance perovskite pure blue lightemitting diodes

in this project we aim to develop metal halide perovskitesbased spectrally stable highperformance pure blue lightemitting diodes leds this research objective is crucial for the development of perovskitebased solutionprocessed costeffective nextgeneration solidstate lighting and display technologies despite achieving perovskite green and red leds with eqes 25 and luminance l 100000 cdm2 the soughtafter perovskite pure blue leds 455 nm peak emission 470 nm have been lagging far behind in their performance with max eqes 8 and l 1000 cdm2 and typically suffer from severe spectral instability due to ion migration and phase segregation these inefficient perovskite pure blue leds hold back the perovskites integration into nextgeneration solidstate lightingdisplay technologies here i will design spectrally stable and efficient mixed clbr halide quasi2d perovskite q2dpe pure blue emitters through compositional engineering in particular by using chlorinated bulky organic cations bocs and introducing a small fraction of large size asite cations the resultant q2dpe will comprise of clrich surface with homogeneous halide distribution and localized lattice distortions within the unit cell and are speculated to possess elevated ion migration activation energies which will suppress ion migration and phase segregation thereby ensuring spectral stability further i will design and fabricate leds with interface engineering and study led test device structures htlonly and etlonly devices to find out suitable pairs of htletls to achieve efficient and balanced charge carrier injection eventually resulting in spectrally stable highperformance pure blue leds the project outcomes will be spectrally stable efficient q2dpe pure blue emitters and highperformance pure blue leds with eqe 15 luminance 50000 cdm2 and lifetime 500 h at 500 cdm2 which largely exceeds the current stateoftheart
leverage synergy by cyberphysical systems for the convergence of the eco systems mobility infrastructure and energy in the circular economy for the society 50

cynergy4mie is a visionary project poised to revolutionize europes industrial landscape by bridging the gap between foundational technology layers crosssectional technologies and key application areas the project addresses the pressing need for efficient resource utilization and synergy creation across ecosystems by actively managing requirements from various key application areas cynergy4mie aims to steer developments in foundational technology layers and crosssectional technologies enabling unparalleled collaboration and resource optimization this approach promises faster timetomarket efficient resource utilization and enhanced technological exchange between key application areas cynergy4mies strategy aligns with the eus agenda and emphasizes urgency resilience technological partnerships and crossdomain integration to champion european competitiveness the projects longterm impact rests on embracing urgency fostering competitive resilience strengthening technological partnerships harnessing ecosystem synergies promoting crossdomain integration advancing ai competence prioritizing sustainability enhancing productivity and ensuring usercentric digitalization while forming strategic alliances cynergy4mie envisions a future where emergent cyberphysical systems serve humancentric needs drive domain convergence and secure europes position as a global technology leader
nanostructure formation during food protein digestion and influence on intestinal transport

the global food system is currently facing great challenges which are mainly motivated by environmental and healthrelated concerns i the existing food resources are not efficiently utilized while some of them are overexploited causing watersoil shortage biodiversity losses etc others are not properly valorized eg seaweeds ii moreover the unhealthy dietary habits of modern societies are leading to a dramatic increase in the incidence of dietrelated chronic diseases eg obesity diabetes etc in this context the food industry is actively looking for novel food sources with added health benefits however to design strategies for a sustainable production of nutritious food products from alternative sources and to predict their potential metabolic responses eg satiety allergenicity etc it is essential to understand how food structure digestibility and bioavailability are correlatedprodigest seeks to investigate this topic from a novel perspective focusing on the mechanistic and structural aspects of the gastrointestinal digestion of food proteins and studying their implications on bioavailability the type of structures formed by the assembly of the digestion products through intermolecular associations or by interactions with physiological medium components as well as the effect of dietary fibres which are abundant in alternative protein sources will be studied and linked to their intestinal transport and susceptibility to trigger metabolic responses to address this challenge a set of advanced structural characterization tools including xray and neutron scattering techniques peptidomic analyses and rheology as well as intestinal transport studies will be combined through a multidisciplinary approach interconnecting structural characterization food science and biotechnology the project outcomes will find potential applications to diverse research areas such as nutrition food technology pharmacology and medicine
endpd slowing down parkinsons disease pathological progression

patients and society expect that technical and scientific advances can provide novel improved answers to address unmet medical needs parkinsons disease pd is the 2nd most prevalent neurodegenerative disorder in the world with profound economic and social impacts the absence of preventive therapies to tackle pd requires the development of new therapeutic strategies for pharma companies aiming to develop molecules for parkinson disease pd and other neurologic disorders fastprinciple is developing a new drug candidate to be used as a future therapy to slowdown pd progression unlike alternative solutions such as the ones commercialized by bial acadia pharmaceuticals abbvie lilly and others which target the symptoms we expect to slow down the disease progression increasing current therapies effectiveness overtime pd affects more than 10 million people globally and has an enormous social and economic burden current treatments manage the symptoms of the disease but do not offer the patients the possibility of a cure unfortunately as the disease progress to higher debilitating stage the patient stops responding to the current symptomatic therapies ending without therapeutic options we have identified a molecule that with the companys patented reformulation technology will improve the drug efficacy and slowdown the disease progression of the disease the current proposal aims to establish fastprinciples strategic monetization plan by securing ip strategy and to ameliorate our business and exploitation plan
golexic transforming intervention for dyslexic children

golexic is an app that helps children with dyslexia and reading challenges improve their reading and writing skills thanks to an innovative accessible effective and affordable solution it leverages a structured teaching approach developed for dyslexic learners and uses speech recognition to drive reading practice and assess childrens skills and challenges this in turn drives the personalisation of the programme for each child this combination of speech recognition and personalisation is a differentiator for golexic compared to other digital learning programmes for children with dyslexia the goal is to scale personalised reading intervention so that parents and teachers have easy access to a robust tool that helps children improve their literacy skills
adaptable technological solutions based on early design actions for the construction and renovation of energy positive homes

the legofit project aims to design implement and validate an advanced and dynamic integrative approach to accomplish eph based on smart and innovative solutions with a high scalability and replicability for building construction and renovation through i developing an innovative holistic design platform that encompass not only passive and active technologies but also their integration for smartest exchange of information and interoperability of systems based on building information modelling bim available for both professionals and endusers ii integrating active and passive strategies eg envelope hvac systems integrated solutions including nature based solutions etc with smart management technologies bas bms for climate neutral and high energy building performance providing maximum flexibility to users iii investigating innovative routes for promoting minimum environmental impacts by the smart use of solid and liquid residues generated during building life cycle stages and iv fostering sustainable stock of buildings by guaranteeing not only the fulfilment of sustainable criteria economic social environmental but also according to the enhancement of smart readiness of buildings this innovative and integrated approach is demonstrated in 3 demos across a range of geographical cultural and construction stagestechnological market maturity scenarios the building typology focus is the residential sector multifamily houses and dormitories including both new and existing constructions the involvement of professionals in the sector is ensured through the development of a community of stakeholders and an open innovation community for building energy system bes professionals training courses focused on the new positive energy house approaches will ensure a new generation of multidisciplinary team of experts on the topic