Dragon09/odtu_chatbot huggingface dataset:
heals effects of the implementation of the interdisciplinary topic health and life skills in schools

mental illness is a major health burden worldwide and the health problems with the heaviest financial burden in norway half of chronic mental disorders emerge before the age of 14 and mental health problems in youth are increasing the norwegian government has implemented the interdisciplinary topic health and life skills hls in primary and secondary education to provide pupils with competences to promote health and selfefficacy schoolbased interventions may improve mental health and academic performance but their effects depend on the quality of implementation there are large variations in how hls is implemented within and across schools due to lack of national guidelines and a reliance on teachers professional judgement delayed implementation for some grades and longitudinal nationwide registry linkages forms a natural experiment and rare opportunity to investigate the impact of diverse implementation methods of a politically determined longterm and populationwide measurethe aim of this interdisciplinary study is to evaluate how variations in the implementation of hls relate to the interventions effect on pupils mental health quality of life school environment academic performance and dropout we will collect new hls implementation data from 5000 teachersemployees 1000 school principals and 180 school owners information from these key samples will be combined with prior linked data for 750 000 pupils from existing national registries and large surveys including educational health and background informationthe research group includes researchers specialized in education mental and public health health promotion classroom research school surveys registerbased studies and advanced multilevel methods the evaluation may affect further implementation and practice of hls nationally and globally and thereby promote pupils mental health and academic performance and thus also their future
astrovalues of work at the observatories in kazakhstan

space exploration is driven by work and values awokaz investigates the role of work and values in creating maintaining and disrupting social relations in and around the observatories and laboratories of the fesenkov institute of astrophysics fai in kazakhstan the research aim of awokaz is to advance understanding of how astronomers herders and tourist guides value and construct their lives in relation to space and space research infrastructures astrovalues in this research are the multifaceted economic imaginative and moral forces that motivate actors everyday practices of engagement with cosmic events and processes these diverse forms of engagement include but are not limited to scientific passions of abstraction touristic forms of commodification and consumption of the night sky and various relations to the stars as guides or mythological figures the project will provide a robust analysis of how the work of astronomers guides and shepherds is mediated by the economic forces of the free market as well as the moral sociocultural values of relating to cosmic processes awokaz will focus on the histories contemporary practices and biographical trajectories of the astronomers tour guides and shepherds who live and work in or around the astrophysical observatories of the fesenkov astrophysical institute fai
singleclone multiomics sequencing for cancer diagnosis

cancer led to one in six death worlds wildly by nature cancer is characterized by abnormal and uncontrolled cellular growth caused primarily by genetic mutations despite of the high cellular heterogeneity only a small number of somatic mutations shown to be directly associated with tumorigenesis hence driving cancer growth the first hurdle in the cancer diagnosis is to identify these rare populations that have the potential to develop drug resistance a second hurdle is to be able to associate mutations in the genetic level to the rna expression level which will improve the chance of pinpointing a specific mutation with the relevant activity therefore it is of crucial importance to develop a singlecell multiomics sequencing tool to simultaneously study the heterogeneity of expression and dnabased regulation of cancerassociated genes recently several multiomics tools have emerged that allow for the interrogation of both gene expression and open chromatin regions however there are some notable limitations constrain the capability and applicability of these tools 1 the expensive and disposable apparatuses and reagents of these methods is extremely expensive and thus limits their extensive application and potential as a diagnosis tool 2 the transcriptome derived from all these technologies only captures the 3 rna termini of polyadenylated transcripts it excludes the capture of nonpolyadenylated transcripts which plays a vital role in cancer development and the interrogation of somatic mutation from full length rna 3 the low input of singlecell material leads to the sparse data to overcome these hurdles our novel technology is based on three methods that we have developed leveraging the power of microfluidics 1 singleclone sequencing 2fulllength rna and 3 a cost efffective open chromatin extraction method multicloneseq will be the first method providing lowcost and fullscale multiomic profiling with high resolution
earthquake risk platform for european cities cultural heritage protection

the seismic movements of the ground have a strong impact on the structural stability of the cultural heritage very often characterized by old construction methods and materials but still with a consistent density of population to have an idea of the dimension of the phenomena the damage on the ch asset declared by the italian ministry of ch caused by the recent earthquakes in centre italy has been assessed in 2 billion euro plus the death toll caused by the collapse of several buildings authorities responsible for the preservation of ch to the future generations are well aware of the huge costs required by rehabilitation intervention compared to preventive ones risk information becomes fundamental to reduce the vulnerability of heritage and to minimise the economic losses helping disaster managers and cultural heritage professionals to design mitigation measures set priorities and invest in resilient cultural heritage to mitigate the restoration costs and the death tollthe project era4ch addresses the development of a series of tool combining artificial intelligence with structural stability models advanced remote sensing techniques image processing geotechnics and cadastral data sets in a gis application for damage assessment and longterm monitoring of historic centres this innovative methodology and tools will enable effective monitoring and management of the historic centres to mitigate the effects of the catastrophic events by enabling preventive intervention in the areas where the majority of the damage is expected three representative test cases are proposed the historic city of narni italy candidate to the unesco site list the historical centre of chania crete greece and strovolos nicosia cyprus
climateresilient regeneration and renaturing for by and with vulnerable neighbourhoods striving towards netzero

climagen will demonstrate how climateresilient regeneration and renaturing for by and with vulnerable neighbourhoods can help cities and regions in their transitions towards netzero 5 demonstration cities belgrade gdask tartu torino and trondheim will implement 25 increased share of newly created andor restored public green spaces in each city 4 replication cities clujnapoca eindhoven gernika and thessaloniki will experiment with shorterterm cocreative measures with the same objectives and methods to plan for future implementation of the measures all 9 cities will run their own work packages in climagen supported by 5 crosscutting concepts and 4 transversal wpsclimagreens will nurture integrated renaturing measures that create resilience at several scales and avoid maladaptation in the journey to climateneutrality climalabs will provide local and regional collaborative governance with arts culture and youth entrepreneurship and financing and organisational resilience in longterm planning strategies climaimpact will generate evidencebased decision support and valuation of cobenefits in easytounderstand and where possible visualised formats climavalue will offer outreach capacity building and policy guidance with strategic advocacy together with sister projects and close collaboration with missionsneb communities while an evidencebased climagen guidance package will disseminate results and knowledge to cities city dialogues and crosscutting sensemaking sessions will support local implementation and common learning together these define impact pathways to knowledge sharing scaling and replication the climagen games will tie these activities together with a portfolio of participatory gamified citizensciencebased methods to engage all partners and stakeholders in an inclusive manner and to use their diversity as a strength
european researchers night in sweden 20222023 forskarfredag 20222023

forskarfredag researchers friday is swedens most widely dispersed science festival forskarfredag 2022 and 2023 ff202223 will consist of events arranged in 26 cities and an online programme open to anyone in total ff202223 will engage around 109000 attendees and 1360 researchers the nonprofit association va public science has coordinated ff annually since 2006 ff202223 builds on previous years drawing on experience contacts and an everincreasing profile the ff motto is researchers are ordinary people with extraordinary jobs at ff202223 members of the public will meet researchers and participate in activities designed to stimulate dialogue and show that research is exciting and relevant to everyday life debates science cafes competitions shows experiments and handson activities common themes around eu priorities will inspire activities exploring the role of research in tackling societal challenges a collaboration with 6 other ern projects will deliver a set of europeanwide activities highlighting the european dimension of research young people aged 619 are a key target group a school programme will offer numerous opportunities for encounters with research the borrow a researcher concept will enable 9000 pupils across sweden to meet a researcher in school or virtually a national mass experiment citizen science project inviting pupils to work with researchers will involve appr 50000 people local events physical and digital expected to reach around 25000 attendees annually will be organised by 11 partners and 21 external partners each event builds on local strengths and networks to give the highest possible impact all event organisers share experiences in a national network va is responsible for the coordination quality assurance common activities national identity awareness campaign and impact assessment of ff2223
groundbreaking biocontrol solutions for a resilient agriculture

pertinent is developing products that combine the effectiveness of chemical pesticides with the safety of biocontrol productspertinent is applying to a blended funding program combining 25m of grants and 6m in direct investment to cover commercialization of its first products and its accelerated growth journey in the crop protection market the funding coming from the eic accelerator challenge 2023 novel technologies for resilient agriculture will be critical to help pertinent accomplish the following steps conduct the final studies to lock the product formulation for eu and the us register the active substance and get market authorisations build a commercialization organization in the eu and us successfully launch the selected products in the targeted crops for eu usa and brazil and mexico build production capabilities in france to supply the growing demand 10m in capex build a rd lab to formulate the new products test them and conduct analytical studies 2m in capexthe main milestones of the project are2024 launch of first crop protection biocontrol products in california grape vines and berries2025 temporary market authorisation in eu for sugar beets and grape vines first launch in mexico2028 launch in europe under full market authorisation pertinent has already established a network of partners in europe and in the usa that will support its business efforts and have written letters of support in rd universities testing labs manufacturing suppliers and contract manufacturers field testing and validation technical institutes and commercialization distribution agreement already signed for europe with de sangosse prominent investors have also expressed in written loi their strong interest in participating in the next round of funding along the eicthe expected outcomes of the program are the successful launch of one or two products in the eu the usa and brazil and mexico generating 247m of sales in 2028
testing nuclear coalescence with nucleiantinucleon antinucleinucleon balance measurements at the large hadron collider

a hot topic at the large hadron collider lhc is the production of antinuclei in ultra highenergy collisions at the lhc nuclei with very low binding energies are not expected to survive the dense and hot final state environment this project aims to investigate the nuclei and antinuclei production in relativistic hadronic collisions at the lhc to test the microscopic mechanism of their production which is still under debate in particular this project would focus on the first experimental measurement of how quantum numbers in particular baryon number of produced deuterons are balanced by other hadrons in protonproton pp collisions one can in this way experimentally test the coalescence hypothesis of nuclei production directly by measuring if the proton in the deuteron is balanced by an antiproton exactly the same way as for a free proton if this is the case then it indicates that the proton in the deuteron is formed in the same way as a free proton the idea to perform these measurements is presented in this proposal for the first time and has never been performed before the same measurements can also be compared with the predictions from the famous pythia8 model whose development and maintenance are centered around the lund university theory group the balance is expected to depend on transverse momentum and could depend on multiplicity as this controls the number of final state interactions to make the highest precision differential measurements the analysis will use 136 tev pp collision datasets to be taken in run 3 20222025 with the recently upgraded alice detector that can handle rates that are 10100 times larger than before the upgrade the ability to perform the measurements takes advantage of the expertise of the fellow and the supervisor who both have a long association with alice collaboration at the lhc and has the necessary expertise and network to carry out the measurements
novel functionalization of liposomic nanovehicles for stronglyenhanced drug delivery

delivery to diseased cells or tissues of therapeutic agents attached or encapsulated in nanoparticles nanomedicine presents many benefits and comprises a rapidlygrowing multibillioneuro market lipidbased drugdelivery nanovehicles where drugs not least the recent verywidelyused mrnabased covid19 vaccines are encapsulated in lipid vesicles liposomes or lipid nanoparticles form a substantial part of that market nearly all fdaapproved liposomic vehicles are functionalized with polyethylene glycol peg moieties the current goldstandard these act both to stericallystabilize the vesicles and importantly increase their bloodretention time and thus their therapeutic efficiency at the same time such pegylation has several drawbacks including reduced cellular uptake accumulation of peg in tissues and accelerated blood clearance on repeated intravenous dosage due to heightened immune response we use novel functionalization approaches to overcome these drawbacks the present project explores the innovation dimension of our new approach in particular is it effective is it efficient how widely applicable is it what is the ipr position for future exploitation of this new strategy these questions illustrate the highriskhighgain nature of this proposal and are addressed here through several interrelated work packages success of our project in demonstrating that our novel approach is significantly superior to the current universallyused pegylation would not only have a therapeutic advantage for many diseases but also tap into a large and growing market
softexoskeleton suit to restore autonomous locomotion

imagine putting on a pair of pants it feels soft like ordinary clothing fabrics but unlike any other this one is made of highperformance robotic soft actuators and soft sensors this is my vision of future exoskeletons being just like everyday clothing light soft and powerful enough to fully support the wearerthe loss of the ability to walk is devastating for many suffering from stroke spinal cord injury and alike an ergonomic lightweight exoskeleton can surely help these patients to walk again autonomously this is challenging due to large gaps between conventional rigid body dynamicbased walking control and soft structures because such an exoskeleton has to integrate highperformance soft mechatronics to perform walking to an unprecedented extent i am uniquely qualified to achieve this due to my extensive experience in the fields of robotics and neuroengineering as well as my leading role in the engineering of worldleading highperformance humanoid robots which incorporate control modelling and experimental evaluationstroll will develop a soft wearable robotic exoskeleton to restore the walking capability of patients with lowerbody paralysis the soft wearable exoskeleton that i propose to develop will combine groundbreaking innovations in advanced highperformance textilebased actuators lowerbody tactile sensors and advanced locomotion control stroll will investigate new control strategies and methods for tactilebased control for balancing and walkingas its ultimate goal stroll will take on the ambition to enable a lowerlimb paralysed person to take a stroll in the park with an autonomous soft textile exoskeletondespite the methodological difficulties and the uncertainty of the results the project is more than worth pursuing as the payoff is highly significant to benefit the lives of millions of patients suffering from lowerlimbs disorders
heritage protocols for architectural european crossbordering sites evaluations

hephaestus develops digital information models and reliable 3d databases for cultural heritage routes chrs across european border territories defining collaborative intersectoral protocols to enhance the architectural cultural heritage and improve sustainable planning and management processes it bears on the physical materiality and critical role of fortifications and military architecture as building complexes that usually embody the emblem of historical geopolitical and societal limits to turn them into digital systems that unify administrative models across european borders military architectures paradigms transcend regional characterisations and are based on models that coexist in different countries lending themselves to generating management systems that overcome bordershephaestus brings together historians surveyors 3d modelling experts software developers and urban planners in a partnership of universities research centres small and mediumsized enterprises and cultural institutes from italy germany poland and croatia the specific and complementary expertise of partners enables the structuring of a multiphase methodology that includes digital data acquisition 3d semantic modelling models and databases association digital twins development open data platforms development and definition of standardised multiscale databasesthis project structures a novel way to investigate fortification chrs according to a scientific model promoting the digital transition and on a european level the development of a programmatic charta of documentationforintervention which can be applied on a broader scale through digital twins based on informative systems hephaestus codifies a novel and cuttingedge representative language for the widespread heritage of chrs moreover it creates potential market opportunities for nonacademic participants thus bringing significant benefits also for european societiescultures
exploring neuronal functions of nalcn in health and disease

the resting membrane potential of a cell is a crucial element of signal transduction across cell membranes and temporary changes are the basis of neuronal excitability the key ions in the process are unequally distributed intra and extracellularly and ion channels are regulating the transport one of the main ions involved in this process are sodium ions the depolarizing sodium influx on the resting membrane potential is primarily mediated by the sodium leak channel nalcn the neurological syndromes ihprf1 and clifahdd originate from nalcn gainoffunction gof and lossoffunction lof mutations yet patients have overlapping or highly similar symptoms therefore a genotypephenotype correlation for these symptoms remains unclear here we aim to understand genotypephenotype correlations by establishing gof and lof patient mutations in a human induced pluripotent stem cell system and characterizing these mutants impact on neurological activities and comparing these to the wild type to further expand our understanding of the patient mutations i will use computational approaches such as molecular dynamics to characterize nalcn wt compared to the above nalcn missense mutations together with the already available clinical data and the data obtained by the pless lab in heterologous expression systems this will provide the first comprehensive overview over the detrimental effects of nalcn gof and lof mutations to date no negative or positive nalcn modulators have been found or developed to fix patient gof or lof mutations respectively we aim to identify nalcn modulators using both in silico docking and in vitro tevc and patch clamp screening approaches to treat these neurological phenotypes pharmacologically and thus potential drugs to rectify the effects of nalcn dysfunctions potentially serving as drug therapy for patients suffering from clifahdd and ihprf