Dragon09/odtu_chatbot huggingface dataset:
photoinduced electron dynamics at the transitionmetal oxidewater interface from timeresolved liquidjet photoemission

photocatalytic water splitting using transition metal oxides tmos has the potential to play a key role in the sustainable largescale production of hydrogen due to their activity costeffectiveness and stability tmos are viewed as attractive materials to catalyze water splitting by harnessing solar energy a major challenge is effectively preventing the recombination of electrons and holes in the tmos produced upon solar light absorption while these charge recombination processes occur on the picotonanosecond timescale the whole water splitting process is almost 12 orders of magnitude slower this huge difference urgently demands a better understanding of the underlying mechanisms and chargedriven chemical reactions involving electron transfer reduction reaction or hole transfer oxidation reaction that take place at the tmo semiconductorliquid interface in my waterx project i will investigate these sub10picoseconds processes at the interface of tmo nanoparticles in bulk water by using timeresolved femtosecond laser photoelectron spectroscopy by applying liquid microjet setup the objective is to measure the earlytime molecular intermediates and their associated electronicstructures their lifetimes energetics photoelectron angular distributions and decay mechanisms of the shortlived molecular intermediates with this knowledge we can determine the exact mechanisms of lightinduced water dissociation and will pave the way to manipulating lightinduced interactions to the solidaqueous interface for improving the efficiency of lighttoenergy conversion these novel experiments will be performed for four nanoparticle photocatalysts hematite titanium dioxide cerium oxide and nickelironoxyhydroxide with manifold electronicstructure properties bandgap charge carrier dynamics and energetics which make them attractive for future applications
training the nextgeneration of european glioblastoma translational researchers to resolve precision targeting of the brain tumour microenvironment

isocitrate dehydrogenase wildtype idhwt glioblastoma gbm is the most frequent aggressive and lethal brain tumour it has a universally fatal prognosis with 85 of patients dying within two years effective precision medicine therapies are thus urgently required this can only be achieved by focused multisectoral collaborations in innovative research disciplines overall glioresolve will exploit the intractability of gbm to address european applied biomedical research training needs and will train 10 innovative entrepreneurial doctoral researchers drs the research objectives of glioresolve are i to extend immunotherapy options to idhwt gbm patients and identify novel tumour microenvironment tme subtypespecific therapeutic targets ii develop and optimise state of the art preclinical models that recapitulate gbm tmesubtypes and iii test novel rationally selected available drugs drug combinations for precision treatment of idhwt gbm based on tme subtype assignment cumulatively the programme seeks to generate sufficient data to support a postproject phase 2 clinical trial the consortium brings together leading european academics clinicians private sector and notforprofit partners and incorporates disruptive research methods including multiomics exvivo tumouronachip assay development computational modelling and systems biology overall glioresolve provides a comprehensive translational research strategy that goes significantly beyond the current stateoftheart in neurooncology to establish a new tmetargeting precision medicine platform for this incurable disease the glioresolve network addresses current needs in academia and the private sector to train doctoral researchers in an environment that spans multiple disciplines thus glioresolve drs will be able to navigate confidently between clinical academic and private sector environments to progress applied research findings towards improved patient outcomes
a continuous process of the direct mechanocatalytic suzuki coupling

the major contribution to chemical waste accumulating in chemical industry is made by solvents often organic solvents potentially toxic or harmful for the environment my ercstg mechanocat targeted this challenge by removing solvents entirely from chemical processes using a concept called mechanochemistry in mechanocat i applied mechanochemistry and targeted the famous suzukicoupling reaction being one of the most popular catalysis in chemistry the breakthrough of the project was the utilization of a principle to this reaction that we denoted as direct mechanocatalysis dm applying dm the catalyst neither must be added as molecule or complex as in homogeneous catalysis nor as solid powder as in heterogeneous catalysis the milling ball itself served as catalyst because it was made from the catalytic material this allowed for the easiest everpossible way of catalyst separation and reutilization simply taking the milling ball out of the milling vessel despite its great economic and ecological advantages our principle has only been demonstrated on the scale of milligrams using conventional laboratory mills running in batch modeto advance dm from lab curiosity to true innovation the ercpoc project mechanoextrusion will thus transfer dm to a continuous process at larger scale by giving the experimental evidence that one of the most popular reactions in pharmaceuticalmedical chemistry the suzuki coupling can be conducted in a pdcoated extruder applying 100 times upscaled substrate quantities in order to show that dm can become a true alternative to conventional catalysis mechanoextrusion will further on quantify the economic and ecological metrics using lifecycle assessment and market analysis it will target ip protection create industrial partnership to establish a first joint project and elaborate a business plan for potential spinoff foundation
infant nutrition cognition and health

the complementary feeding period ie the time when infants are introduced to foods and liquids different from milk has important implications for childrens longterm social physical and cognitive developmentwhile a large number of studies have surveyed the types of weaning foods provided there is still a significant lack of research on the behavioural aspects involved in this important transition period in terms of outcomes existing studies have mostly focused on health effects with very little attention paid to cognitive or language developmentlastly most of the existing research is based on data from western industrialized countries leaving us with a very incomplete picture of infant feeding practices and the resulting outcomesusing a bottomup approach my project aims to fill these gaps by developing standardized tools for measuring infant feeding practices in rural and urban african settings and investigating the impact of different feeding practices on childrens health and developmental outcomesbuilding on local contacts and relevant experience from a decade of research in africa i will 1 use focus group discussions to create a culturesensitive questionnaire for measuring infant feeding practices 2 use the questionnaire for a survey of infant feeding practices across rural and urban communities in kenya 3 collect detailed data on infants nutrient intake 4 assess childrens motor cognitive and language development using tools which have been validated in similar african contexts and correlate my data from 2 3 and 4 to 5 identify feeding practices which relate to positive outcomes and can form the basis of future interventions
innovative approaches for an integrated use of algae in sustainable aquaculture practices and highvalue food applications

the farm to fork strategy of the european green deal has acknowledged the potential of algae to become an important source of alternative lowcarbon footprint protein and contribute to improve the sustainability and competitiveness of the aquaculture sector nonetheless the european algae industry is still at an early phase lagging behind the overall increase seen at a global level mostly driven by asia within this context innoaqua aims to pave the path towards the upcoming sustainable and diversified eu inland aquaculture industry by leaning on the demonstration and mainstreaming of innovative algaebased foods and solutions and ecology circularity and digitalization concepts to this end the project will address main barriers hindering the growth of the sector starting with the demonstration at a precommercial level trl67 of the operational technical and socioeconomic robustness of digitally enhanced integrated fish and algae rasimta cultivation systems continued by the piloting of optimised processing techniques following biorefinery principles and the formulation of high added value seafood products all this accompanied by a dedicated waste minimisation and valorisation strategy to help optimizing and increasing its economic and sustainability performance moreover innoaqua will also work on understanding how consumer perceptions and social norms influence the consumption of innovative seafood products by cocreating the products together with endusers and simulating their uptake in digital models of communities to identify effective market deployment and penetration strategies lastly innoaqua will be enhanced by the adoption of a multilevel outreaching strategy which will the development of robust dissemination communication and exploitation plans materials for skills development and activities to foster international cooperation aimed at fostering knowledge transfer and ultimately helping maximize the projects scope and impact
a transcatheter functional valve replacement for tricuspid valve insufficiency

tricuspid regurgitation tr is a cardiac disorder in which the tricuspid valve leaks during systole causing blood backflow resulting in decreased cardiac output tr is the most common valvular heart disease affecting 6585 of the global population in its mild form however mild tr can progress to severe tr leading to heart failure or death if left untreated today the only option for treatment is valve repair or replacement through openheart surgery which is associated with high mortality rates risks and costs over 3m patients suffer from tr in europe and for the majority their condition is too severe for surgery therefore there is no effective treatment innoventric has developed the trillium a transcatheter tricuspid valve replacement solution the whole procedure is minimally invasive and can be completed in 30mins within the eic project innoventric will finalize the clinical validation of its device ensuring safe and timely intervention for tr patients
building more reliable and performant batteries by embedding sensors and selfhealing functionalities to detect degradation and repair damage via advanced battery management system

phoenix aims to develop battery cells with integrated sensors mechanical enhanced impedance spectroscopy temperature gas reference electrode and selfhealing sh functionalities magnetically activated polymers thermally activated polymers metallic organic frameworks coated separator coreshell nmc composites tailor made triggering devices to activate sh mechanisms will be developed prototyped and demonstrated in generation 3b and 4a li ion batteries a battery management system bms capable of detecting defective operations and of triggering sh functionalities will be developed with inline communication the degradation detection and quality reliability and life qrl will be tested through dedicated profiles fast charging extreme temperatures calendar life the novel batteries manufacturing will be studied from a recycling and mass production point of view phoenixs objectives1develop sensors to detect healable degradation mechanisms2develop materials with sh functionalities triggered by external stimulus to eliminateavoid failure mechanisms in battery cell components3develop triggering devices to activate sh mechanisms4demonstrate proof of concept for coupling sensors and sh agents via bms 5detect critical degradation processes during cell ageing and estimate the qrl over the life span6assess the environmental sustainability and demonstrate the competitive advantage over alternative approaches such as replacement recycling or second use7adopt an adaptable approach towards battery cells mass production processes which do not hinder the subsequent recycling process and enables an economic evaluation of the developed cellsphoenix will collaborate with the battery 2030 initiative and will contribute to europes competitive and sustainable battery manufacturing industry phoenix consortium is a partnership of 4 rtos 1 university 4 smes expert in materials sensors modelling bms recycling and battery manufacturing
coastal fishing vessels powered by zero emission hydrogen fuel cell

h2seas initiative is an innovation action targeting the overarching objectives of the topic horizonmiss2023ocean0105 the initiative proposes a novel fullyintegrated hydrogenelectric fishing vessel to accelerate a sustainable and accessible transition to clean and efficient power for smallscale fishing fleets based on hydrogen fuel cell technology the prototype will demonstrate increased energy efficiency and an environmentally friendly solution for the marine environment zero emissions and low sound pollution the project will be implemented by the design construction and operational demonstration of a hydrogenelectric fishing vessel to test and validate its resilience in the harsh marine environment the outcome will be complimented by the gathering of technical competencies provided by the latvian maritime academy riga technical university and the latvian shipyard atoz which are in charge of major activities of hull design engineering building and testing genevos a french sme leader in the integration of hydrogen technologies in the maritime sector will provide the complete energy system engineering including certified hydrogen power modules gas integration design and installation in parallel survey and research activities will be undertaken by the estonian tallinn centre of the stockholm environment institute and the latvian vidzeme university of applied sciences to report on regulation and barriers for smallscale fishing ship decarbonisation and to assess the environmental impact of the h2seas initiative on the marine environment the distance education study centre riga technical university will implement and maintain effective project management to create and lead dissemination and exploitation of results forming longterm synergies to broaden hydrogen fuel cell energies for smallscale fishing ships perspectives and meet the european green deal objectives and the eu biodiversity strategy for 2030
disruptive drug free treatment of knee osteoarthritis using novel materials and minimally invasive catheter delivery

embosure is a breakthrough treatment for knee osteoarthritis it acts directly on the mechanism of osteoarthritis delivers long term pain relief and stops the progression of the disease for up to 5 years the solution involves embolising or blocking the tiny blood vessels of the knee with patented bioresorbable particles developed by crannmed the bioresorbable embolic particles are tightly calibrated 200m particles made from naturally occurring biocompatible materials which block the small blood vessels of the knee over a five day period this disrupts the osteoarthritic degradation before the particles are completely reabsorbed into the body the particles are delivered through a minimally invasive microcatheter specifically designed by crannmed to reach the tortuous vessels of the knee as the maintenance of blood supply to the knee and the lower leg is critical the bioresorbable particles and microcatheter are key to our paradigm to treat without leaving anything behind
creation of a group of excellence on engineered biofilms

biofilms are complex and dynamic structures of interfaceassociated microbial cells enclosed in a matrix of extracellular polymeric substances they are ubiquitous both in nature and humanbuilt environments greatly affecting the progression of clinical infections environmental sustainability and industrial processes the complexity of these structures renders the apparently simple goal of engineering and growing reproducible biofilms as an elusive task the main objective of this proposal is to setup a group of excellence on engineered biofilms ebiofilm at the faculty of engineering of the university of porto uporto ebiofilm will build upon the expertise and network of experts from the prospective era chair holder darla goeres and her current employee the center for biofilm engineering of montana state university msu the most wellestablished centre in biofilm research in the world in addition to research excellence in engineered biofilms ebiofilm will include a thriving educational and training program a technology transfer program that promotes innovation and adequate communication and dissemination strategies that establishes links with the scientific community industry regulatory entities and the public in general in the european research area
electrically driven dnaorigamibased machines

inspired both by nature and the success of macroscopic machines molecular engineers have been exploring various approaches for the realization of nanoscale artificial molecular machines amms ie molecular constructs capable of controlled mechanical actuation despite the great promise of amms and the tremendous progress in the field especially on the synthesis side multiple conceptual and technical challenges and open questions eg related to amms fabrication implementation of actuation and most important amms functionality still remain here i will combine i the dna origami technique with its ability to construct welldefined complex threedimensional nanostructures and guide the assembly of functional nanoscale objects with unprecedented precision and ii electromechanical actuation to build fast remotely controlled artificial molecular machines with functionalities far beyond the state of the art first i will fabricate amms that translate external stimuli into welldefined spatial reconfiguration of metal nanostructures i will use such amms to build i active plasmonic surfaces with fast remote modulation of optical responses and ii plasmonics probes with singlemolecule detection sensitivity second i will design amms that can exert forces on single molecules such amms will be used to fabricate i nanoscale robotic arms ie devices that can pickup transport and release cargo molecules andor nanoparticles in multiple cycles and ii molecular motors ie devices capable of performing useful chemical or mechanical work and driving chemical systems out of their intrinsic equilibrium fabrication of artificial nanoscale molecular motors has been a longstanding dream of molecular engineersresults of this project will pave the way towards practical applications of dnaorigamibased machines and might lead to a paradigm shift in approaches to fabrication of artificial molecular machines and motors
tessellationbased analysis of dynamic protein structures and their complexes molecular motions meet tessellations marmotte

this year has seen a breakthrough in structural bioinformatics deep learningbased methods most notably google deepminds alphafold2 have demonstrated nearexperimental accuracy of protein structure predictions however even the best protein structure prediction methods do not automatically provide knowledge about protein dynamics and protein interactions which is often essential to understand or predict the biological functions of proteins those functions are performed via intermolecular interactions and such interactions almost always involve conformational changes of engaged partners the problem of modeling dynamic protein structures and their complexes is still largely unsolved this project aims to significantly contribute towards its future solution by exploring the link between computational geometry statistical physics and machine learning the postdoctoral researcher will develop novel methods that given a dynamic moving molecular structure efficiently compute tessellationderived contact areas given a starting structure and its tessellationderived contacts areas predict using a graph neural network how the interatomic contact areas will change upon motion given a protein complex model generated by docking use the predicted statistical properties of the contact areas to estimate using a graph neural network the proteinprotein binding energy score if successfully developed such methods will provide unique data about the dynamics of tessellationderived interatomic contact areas most importantly they will provide effective dynamicsaware scores for assessing and ranking structural models of protein complexes
the unusual role of a highly divergent arp23 complex in the mosquito stages of malaria parasites

the malariacausing plasmodium parasites often use highly divergent proteins to regulate fundamental biological processes such as sexual replication in the mosquito therefore the molecular and cellular biology underlying parasite development is often little understood especially during the mosquito stages a major bottleneck in the plasmodium life cycle recently i identified an unconventional plasmodiumspecific actinrelated protein 23 arp23 complex that mediates dna segregation during male gamete formation and is essential for development of the main replicative mosquito stage the oocyst understanding the regulation and function of this structurally and functionally divergent actin nucleator could provide targets for new antimalarial strategies here i propose to elucidate the molecular mechanism of the plasmodium arp23 complex on three levels 1 i will uncover how arp23 is activated during gamete formation revealing the likely unusual mode of regulation of this complex 2 i will explore the hypothesis that arp23 is linked to a cryptic spindle assembly checkpoint a mitosis regulator so far thought to be absent in plasmodium 3 i will reveal why arp23deficient parasites arrest in oocysts which will shed light on the unusual cell division mode of this elusive stage to address these ambitious aims i will combine molecular biology methods single cell transcriptomics and imaging and i will engineer a new genetic tool to dissect gene function specifically in the oocyst a stage that is notoriously difficult to study plasmoarp will thus not only give insight into the molecular biology of plasmodium development in the mosquito and advance our understanding of arp23 and actin biology across the eukaryotic kingdom but it will also expand the toolbox to study the neglected oocyst as plasmodium arp23 is essential for malaria transmission this research will pave the way for new intervention strategies to mitigate malaria infections
diagnosis of large vessel occlusion lvo in acute stroke for improving access to treatment

lvocheck is a portable diagnostic solution providing fast identification of large vessel occlusion lvo in acute stroke just by analysing a blood drop from the patients fingerpick lvocheck allows rapid triage of stroke patients already in the ambulance so patients suffering a lvo can be directly driven to the closest thrombectomy centre to get the clot removed without the need of a cranial ct scan at the nearest hospital it avoids unnecessary patient transfers and waiting times saving thereby an average of 2 hours from symptom onset to treatment our pilot studies have shown a clinical benefit of 1520 more patients becoming asymptomatic or functionally independentlvocheck is a costeffective worldwide scalable innovation that will transform the triage and treatment of stroke patients lessening the enormous economic and social burden of stroke the use of lvocheck will dramatically shorten the time from stroke onset to therapy reducing disability and saving lives