Dragon09/odtu_chatbot huggingface dataset:
expressing value in language

evaluative adjectiveswords like good ugly tasty and eleganthave interpretations that appear to depend on the context if you describe a knife a bear or an act of charity as good you do not seem to be saying that it has some fixed property of goodness rather the context in which you are speaking affects the interpretation of good evaluative adjectives are closely linked to concepts of central importance in philosophy such as moral goodness beauty and value hence their apparent contextdependence has troubling consequences for many philosophical debates for example an act of charity could count as good when we are talking about it in one context and as not good when we are talking about it in another context due to different interpretations of good this startling conclusion is difficult to reconcile with most ethical theories while philosophers and linguists have shown increasing interest in evaluative adjectives a full analysis has remained out of reach for several reasons first philosophical and linguistic investigations often proceed in isolation from each other second the scope of analyses can be overly specific by virtue of focusing on a single casestudy or overly general by focusing on features that supposedly unify all evaluative adjectives third the predictions that emerge from different analyses are rarely subjected to empirical assessmentthe project aims to give an account of the meaning of the word good and other evaluative adjectives along with the nature of goodness and other forms of value it will be the first fully integrated analysis by incorporating philosophical and linguistic perspectives generalisations about evaluative adjectives and particular casestudies along with empirical results the novelty of the project lies in this integrative and interdisciplinary aspect the results will resolve central and longstanding issues in both philosophy and linguistics
highresolution cryoem structures of the human and yeast sin3 histone deacetylase complexes

histone deacetylase hdac complexes are the main transcriptional repression machineries in eukaryotes disruption of their functions can lead to various diseases such as cancers inflammatory diseases and neurological disorders hdac complexes are composed of multiple subunits that assemble around hdac enzymes which have been the most exploited targets for developing small molecule therapeutics to expand the diversity of targets and inhibitors available to study hdac complex biology and fight hdacrelated diseases the applicant developed phenotypic screens focused on the sin3 hdac complex in human and yeast during his phd training he also used proteomics approaches to study the global cellular effects of new compounds and predict their targets however the absence of highresolution 3d structures for the sin3 hdac complex has hampered the precise understanding and validation of how drugs bind to specific subunits and perturb the overall architecture of the complex to reprogram its biological functionshere we are combining the expertise of the applicant in hdac complex biology and druggability to that of his host laboratory in cryoelectron microscopy cryoem to solve the 3d structures of the human and yeast sin3 hdac complex at near atomic resolution this complex is highly conserved between species and is formed by a dozen proteins making it an ideal candidate for singleparticle cryoem the applicant has already acquired promising preliminary data including partial purifications of both human and yeast sin3 hdac complexes the pioneer structures that will emerge from this work will have a high impact in the fields of transcriptomics and epigenetics since they will improve our understanding of hdac complex arrangements while helping validating longstanding hypotheses on transcriptional repression mechanisms the proposed 3d models will also serve as starting points for further systematic structurebased design of new hdac complex inhibitors
multimodal brain imaging gene relationships in alzheimer disease risk and resilience

the list of genes contributing to increased risk of developing alzheimers disease ad grows every year to date large casecontrol genomewide association studies have found 98 genetic loci associated with lateonset alzheimers disease load however apart from a small number of genes related to familial cases it remains largely unknown the direct relationships between genes amyloid and tau misfolding protein accumulation hallmark of ad and neurodegeneration of the human brain even more striking current knowledge of mutations potentially conferring genetic resilience is sparse a better characterization of each genetic risk loci and identification of protective genetic variants could lead to development of effective therapeutical targets actually unavailable for ad the goal of this project is to characterize associations between the 98 load genetic risk loci in vivo tau and amyloid pet and mri neurodegeneration including an examination of potential genetic variants conferring disease resilience hypotheses genetic loci will show distinct spatial patterns of tau and amyloid spreading and neurodegeneration helping us to better understand ad biological heterogeneity i expect to find different subtypes of ad with different molecular mechanism and different therapeutical targets for each subtype i will use pet imaging of 3000 participants from the harvard aging brain study and the a4 and adni databases 35000 participants from the uk biobank with genetic and functional and structural mri will also be used to study the impact of genetic loci on neurodegeneration importantly as a first analysis we will search for the effects of each risk loci and protective variants conferring resilience secondary analyses will also explore the contributions of sex and ethnic minority factors
biodiversity change across time and space in the anthropocene leveraging metacommunity modelling landuse change and open data to achieve deeper understanding

despite connections between metacommunity level processes that maintain biodiversity and anthropogenic pressures that erode those processes these have not been well integrated i propose a multifaceted approach that1 builds on metacommunity theory to develop expectations for the influence of anthropogenic drivers on scaleexplicit biodiversity change2 uses this theory to develop an analytical pipeline to disentangle local and landscape factors driving this change3 use the derived results to develop scaleexplicit projections of future biodiversity change that can aide biodiversity policy decisionswith theoretical expectations and analytical procedures in hand we will synthesize biodiversity change across scales and the relative influence of local versus landscapelevel drivers on those changes we will apply our analytical pipeline to the largest compilation of metacommunity time series to provide a comprehensive analysis of biodiversity change we will complement this with a data collection campaign to resurvey zooplankton metacommunities from ponds that had been surveyed 1050 years previously but which have experienced different levels of background change eg loss of nearby habitat we will also compile a database to explore the potential influence of habitat restoration via local and landscape processes and its influence on scaleexplicit biodiversity change we will analyse these synthetic datasets together with geospatial driver data using our novel analytical pipeline finally we will develop a unique pipeline integrating metacomunity theory with our synthetic results and machine learning to develop projections of biodiversity change in the face of scenarios of anthropogenic change with the information gained we will contribute not only to a better understanding of the most important feature of life on this planetits biodiversitybut by developing this understanding we can provide an avenue to mitigate the changes
twin wind tunnels for energy and the environment innovations and excellence

tweetie aims to upgrade the wind tunnel wt testing activities of the widening member national technical university of athens ntua the ntua wt will be rendered on par with other world class facilities for hosting a variety of research applications in the field of external aerodynamics primarily focusing on cleantech energy and transport applications tweetie is conceptually based on three distinct pillars i enhancing administration and management capacity ii upgrading technical competence and iii improving visibility and profile of the facility it includes knowledge transfer and networking activities with 4 leading european universities which have all been successfully operating their own large wts for decades and have remarkable scientific and research track recordsrenewable energy sources cleantech and energy efficiency in the urban environment will be the cornerstones for accomplishing eus energy and climate ambition to render europe the first energy neutral continent by 2050 and wt experiments are indispensible for analyzing issues related to wind energy and environmental flows this is one reason that upgrading the inhouse wt has been prioritized as a research goal of paramount importance for both the school of mechanical engineering ntua and the labs involved in the wt management and operationstweeties primary goals will be achieved through systematic work and seamless communication between project working groups comprising key personnel from all partners and a series of networking training and research activities and events in which all leading members of the consortium play an equally important role tweeties strategic research goal is to address the challenge of measurement conformity among different wt four identical stateoftheart test campaigns will be repeated in different tunnels serving the strategic goal the improvement of ntuas technical capacity and also stimulating research innovation and excellence per sen
evolutionary mechanisms in the milky way the gaia data release 3 revolution

the understanding of our home galaxy stands at a crossroads thanks to the gaia mission of the european space agency combined with groundbased surveys previously unexplored portions of the milky way have recently been mapped opening a new era in galactic astronomy and astrophysics in 2022 gaia data release 3 will publish the largest chemical and radial velocity stellar catalog ever created for the first time chemical abundances of stellar atmospheres will be linked to the positions and motions of stars over the entire sky taking advantage of the unprecedented wealth of chemodynamical data the emmy project aims to tackle outstanding questions about the mutual interplay of different evolutionary mechanisms in the galactic disc including the influence of the milky ways satellite galaxies along with secular evolutionary processes specifically the emmy project aims to 1 map chemodynamical inhomogeneities in the galactic disc 2 determine the extent to which the observed inhomogeneities can be attributed to internal processes such as the actions of the spiral arms or the bar 3 constrain the role of external influences such as satellite interactions on the disc evolution the objectives will be assessed through an optimised galactic cartography which will link inhomogeneities in stellar density velocity chemistry observational results will be then compared to cosmological simulations and chemical evolution models to constrain spiral arms formation scenarios and disc heating processes the multidisciplinary nature of the project is strong combining interdisciplinary knowledge of astronomy physics statistics data mining and big data analysis the results of the proposed project are expected to give a cohesive statistically robust accurate and informative picture of the physical processes in the galactic disc which have the potential to represent an important contribution to our understanding of the galaxy and its place in the universe
global value chain law constituting connectivity contracts and corporations

ongoing struggles over vaccine supplies forcefully illustrates the extent to which global value chains gvcs serves as central infrastructures of the global economy and global society while the covid19 pandemic might have been a revelation in this respect the centrality of gvcs dates back to the dawn of colonialism both historically and in contemporary times gvcs produces profound environmental and socioeconomic externalities in jurisdictions often incapable of or unwilling to effectively regulate abhorrent working conditions and environmental degradation hence the question of how to legally regulate crossborder economic processes including the capability of democratically organised political processes to effectively regulate gvcs is a central legal problem within fields such as competition contract and corporate law as well as environmental human rights and labour lawuntil recently voluntary soft law measures were the preferred regulatory tools in relation to gvcs in the last few years a decisive move towards hard national and eu regulation has however taken place thereby raising the question to what extent this changes the rules of the game on the backdrop of this development globalvalue develops a novel and systematic sociolegal approach to gvc law this is done in a threefold manner firstly through a historical sociological reconstruction of gvc law going back to colonial law countering the currently dominant ahistorical approaches to gvc law secondly through three comprehensive case studies in relation to the global pharmaceutical wine and trade fairs industries spanning five continents and nine national jurisdictions the case studies will illuminate the effects of contemporary hard and soft law practices of gvc law thirdly through the development of a new concise conceptuality of gvc law with direct implications for our understanding of core legal concepts such as contract legal order and economic constitutionalism
advanced securityforsafety assurance for medical device iot

advances in healthcare it systems have resulted in complex sociotechnical architectures which deliver integrated and patientcentered services all these transformations in addition to clinical benefits they also introduce risks including security risks that need to be understood and managed reduced to acceptable levels there are numerous reports of new types of security vulnerabilities for this kind of architectures which challenge the effectiveness of the current security tools medsecurance will conceive novel methodologies infrastructures and technologies that enable an effective harmonious and continuous development and evolution of secure system engineering management activities in internet of medical things iomt our objective is to advance knowledge and basic understanding of decision making in diverse iomt threat landscapes based on different system and component level interactions this is accomplished via the development of a novel holistic strategy that considers the interdependence of several iomt subsystems information exchange risk thresholds and regulatory ramifications we provide scalable and verifiable secure system engineering management solutions that capture communicate and act on these complexities in order to improve decisionmaking in cyber defence while automating cybersecurity assurance our solutions will be codeveloped and validated with our medical industry user partners and complemented by engagement of healthcare industry stakeholders in support of the recommendations to existing guidelines that will also be developed in the project
enhancing robustness and security of edge ai systems for safetycritical applications

the guardai project seeks to enhance the security of edge ai systems addressing their critical vulnerabilities emphasis is placed on highstakes domains as outlined in the eus ai act where these systems including drones connected and autonomous vehicles and network edge infrastructure are becoming widespread and will play a pivotal role in making crucial decisions these cuttingedge applications heavily rely on realtime decisionmaking and the processing of sensitive data rendering them susceptible to various security threats and adversarial attacks therefore the overarching objective of guardai is to develop the next generation of resilient ai algorithms tailored for edge applications leveraging cuttingedge technological advancements the project will develop innovative solutions to ensure the integrity security and resilience of these systems fostering trust and accelerating the safe adoption of aidriven technologies a holistic contextual understanding will be integrated enabling systems to adapt and make informed decisions in dynamic environments through a multidisciplinary and multifaceted approach by bringing together researchers industry experts government agencies ai practitioners and advanced threat analysis methods and robust ai algorithms guardai aspires to create a paradigm shift in ai security the development of standardized evaluation criteria forges a path to certification frameworks and realworld insights facilitate a systematic approach to ensuring securitybydesign concepts embracing a holistic approach guardai also examines ethical considerations in ai technology development to promote ethically sound digital landscapes overall the project will strive to elevate the standards of secure ai systems through cuttingedge advancements and a comprehensive collaborative approach
framework for defining climate mitigation pathways based on understanding and integrated assessment of climate impacts adaptation strategies and societal transformation

according to the eus climate adaptation strategy com2021 82 improving knowledge and managing uncertainty is key for realising the vision of a climate neutral and climateresilient union as climate change is having such a pervasive impact that our response to it must be systemic thus there is an urgent need for an integrated approach for an enhanced understanding of the interaction complementarity and tradeoffs between adaptation and mitigation measures especially regarding the expected increase in regional mean temperature precipitation and changing soil moisture ipcc ar6 wg i furthermore this understanding and knowledge needs to be provided to a broad audience to support local authorities in eu partner countries in developing regional programmesknowing aims to develop a modelling framework to help understand and quantify the interactions between impacts and risks of climate change mitigation pathways and adaptation strategies the framework will be used to assess thadvancing climate science and further broadening and deepening the knowledge base is essential to inform the societal transition towards a climate neutral and climate resilient society by 2050 as well as towards a more ambitious greenhouse gas reduction target by 2030 there is a need for research that furthers our understanding of past present and expected future changes in climate and its implications on ecosystems and society closing knowledge gaps and develops the tools that support policy coherence and the implementation of effective mitigation and adaptation solutionscurrently there is a lack of knowledge of the earth system and the ability to predict and project its changes under different natural and socioeconomic drivers especially regarding complex interrelations rebound effects and behavioural aspects therefore a holistic systemaware and behaviour centred approach is needed to identify and implement realistic and effective climate mitigation pathways
strengthening the research capacity of turkey in innovative business models for the hospitality sector

remodel aims to strengthen buu ri capacity and skills through leveraging the experience and stateoftheart knowledge and digital tools made available by twinning partners ule and atu in business model innovation bmi buu staff will significantly enhance their management and administration skills thanks to the capacitation and networking activities a novel bmi laboratory bmi lab will be created leveraging and combining the strengths of ule consumer behaviour analysis laboratory and atu dicelabs and will become instrumental for the execution of the ri part of the project by applying the acquired knowledge and skills in consumer behavioural analysis neuromarketing research management business innovation leadership and entrepreneurship developing business models for 10 turkish smes in the hospitality sector in the context of covid19 pandemic the bmi lab will be an ri pole for buu academic staff and will bring benefits to sme in all sectors contributing to business sustainability and employment creation a longterm scientific strategy will be developed including staff exchanges the definition of common joint ri programmes related to bmi and the creation of an international master on business management in the hospitality sectorremodel goals are perfectly aligned to the expected topic outcomes and impacts as will increase staff capacitation and scientific excellence and will provide a stateoftheart bmi lab to transform buu in a leading institution in turkey on bmi in the hospitality sector boosting heindustry cooperation the preparation and leadership of eu funded proposals increasing its reputation within a defined network collaborators under a longterm cooperation strategy and advocating novel ri incentives schemes to turkish funding agencies and policy makers this strategy will sustain ri facilitate the exchange of students researchers and academic staff and increase the mobilization of resources at national and eulevels
missionary engagements extractive histories and indigenous land

this research project aims to study the entanglements and discrepancies between indigenous understandings of history and colonial narratives created by missionary intervention amongst the shuar people of lowland ecuador it will examine how history indigenous memory and cultural transmission have been developed and produced in the context of missionisation and colonial pressure it aims to understand how colonial history still impacts indigenous politics today shaping current indigenous engagements with largescale resource extraction and allowing extractive capital to endure and perpetuate over time to achieve these objectives this research reviews the historical archives available in the region from the salesian and franciscan missions since the late 19th century will collect and archive film footage of testimonial memories from indigenous participants on their complex relationship with the missionary endeavours and boarding schools and will map how missionary presence shaped indigenous land the use of these three different methodologies will be combined to provide a clear ethnographic study that aims to understand and describe the longterm effects of colonial entanglements on peoples attitudes thinking and current political developments overall this research project is concerned with colonial residues and proposes to look at land demarcation history and cultural transmission to understand not only the impacts of colonialism in its tangible political ubiquity but also in its pervasive and intangible influence over concepts that help people define their worldview