Dragon09/odtu_chatbot huggingface dataset:
design of catalytic processes with deep eutectic solvents

the decades doctoral network will conduct innovative research while training 10 phd candidates with the interdisciplinary skills intersectoral experience and entrepreneurial mindset to implement sustainability concepts in the european biotech sector making a significant contribution to achieve the green deal objectives of european union decades will focus on solvents as central part of the sustainability of biotechnological processes deep eutectic solvents dess are biobased and biodegradable solvents that hold potential to revolutionize the chemistry of the 21st century aim is to apply these safe and sustainablebydesign solvents to increase efficiency and sustainability of industrial biocatalysis decades will bring to fruition the benefits of dess by bridging current proofofconcept knowledge from academia to industrial applications and by a holistic exploitation considering solvent design and application through multiple aspects catalyst substrate environmental impact and along the whole pipeline upstreamdownstream decades will greatly contribute to the transition to synthetic processes based on circular economy by establishing biocatalytic synthesis of several valueadded biobased chemicals decades emphasizes particularly the engineering of multistep catalytic reactions in dess the scientific approach of decades is highly interdisciplinary and brings together biology chemistry and process engineering to achieve significantly increased productivities and diminished waste commercial relevant processes will be upscaled together with industry for which continuous processing will be of main focus 10 nonacademic partners ranging from hightech smes to large producing companies and 6 academic institutions offer an intersectoral and interdisciplinary environment to provide 10 phd candidates with outstanding employability profiles for the european biotech sector both in academia and in industry
v a l i d a t e validation of a trustworthy aibased clinical decision support system for improving patient outcome in acute stroke treatment

based on previously developed models and an existing prototype of a clinical decision support system patent pending we set out in this project to further develop test and validate this clinical decision support for the treatment stratification of acute stroke patients to improve patient outcome machine learning mlenabled artificial intelligence ai methods are increasingly adopted in the medical field implementing mlbased cdsss have the potential to be go beyond the current clinical stateoftheart as ai excels at finding complex and nonlinear relationships across a multitude of prognostic variables ai also has the promise to combine different modalities such as imaging and clinical values leading to powerful stratification tools accounting for a multitude of patient subpopulations our consortium combines excellence in technical and medical machine learning development with the clinical expertise of three leading stroke hospital partners additionally our consortium benefits from the special expertise in the development of trustworthy ai software design and the translation of ai models to the clinical setting with focus on the regulatory process by leveraging the available medical data and exploiting technological opportunities in the field of ai and developing and validating trustworthy ai solutions to be implemented in the clinical workflow we are seeking to surpass the clinical stateoftheart by making a significant and sustainable impact on the treatment of acute stroke that will improve patient survival outcome and quality of life the results of our work will serve as a pathway for future projects and we will make our experiences public in the form of standard operating procedures sops in the areas of development testing validation and regulatory processes
deception in democracy political lying accusations and their effects on democratic citizenship

in todays age of misinformation politicians are frequently accused of bending the truth to their advantage as citizens rely on accurate and accessible information to meaningfully engage with politics political lying violates the contract between citizens and their elected representatives political lying accusations therefore have the potential to erode citizens trust in and commitment to representative democracy as a system of governancewhile political lying accusations may be as old as politics itself we know little about when accusations of political lying take root how accusations of political deception are perceived by citizens and what their effects are on citizens democratic citizenship to shed light on the issue of political lying accusations and its implications for democratic citizenship this project 1 describes the historical trends in political lying accusations 2 identifies the conditions under which politicians accused one another of deception and characterizes the attributes of both the accused and accusers of political lying 3 studies citizens perceptions of accusations of political deception by exploring the individual and contextual factors that influence these perceptions 4 investigates the consequences for democratic citizenship by examining how exposure to lying accusations affects citizens trust in democracy their support for liberal democracy as a system of governance as well as their active engagement with politics the empirical analyses focus on 20 european countries and rely on an integrated multimethod approach including automated text analysis qualitative interviews observational and experimental surveys and longitudinal survey evidenceby addressing these critical knowledge gaps this project will provide invaluable insights into the dynamics of political deception and its consequences for democratic citizenship
hydrogen production from waste

hyway aims to synthesise hydrogen rich syngas from low cost carbon source and eliminate the environmental issues from conventional waste management eg landfill or incineration hyway advances the stateoftheart in carbonaceous waste management especially plastic waste waste tires waste biomass and crude glycerol for hydrogen production the overall aim of the hyway is to establish longterm consolidated research collaborations between the participating institutions with complementary expertise and knowledge to design and develop carbonneutral scalable and socially acceptable pathways to sort and convert waste to hydrogenrich syngas as part of next generation sustainable fuels through secondments workshops training webinar series and industryfocused events hyway produces multiple avenues for career development crosssectoral experiences and academic training in a multicultural and interdisciplinary environment research results are translated into training materials including formal academic and industry courses on waste sorting chemical recycling technologies process modelling machine learning technoeconomic analysis and life cycle analysis for postgraduate students earlystage and experienced researchers and industry training tutorials for industrial and technical staffs and creating the basis for developing academic textbooks for the wider research community and possibly in undergraduate module delivery there is also a focus on transferable skills with dedicated training activities specially designed to facilitate personal development technological and communication skills hyway delivers through the effective collaboration of 7 member stateassociate country universities and companies and eight third country universities and companies from china japan and australia
gene therapy of rare diseases

more than 300 million people worldwide are suffering from more than 6000 rare diseases nearly all of these rare diseases are caused by a single inherited mutation and cannot be treated effectively repair of the defective gene by gene editing is the only possible curative therapy however only for very few rare diseases such gene editing therapy has reached the clinic the gene therapy of rare diseases getradi consortium aims now to contribute strongly to the establishment of more gene therapies for rare diseases this will be accomplished by training of future leaders in gene therapy of rare diseases preforming ambitious research projects with the following objectives i improving transfer of genome editing tools to target cells ii improving gene editing efficiency and iii improving safety of gene therapy strong participation of the pharmaceutical industry to research projects and training development of novel in vitro and in vivo models for rare diseases to test gene therapies in relevant settings and application of several unique genome editing tools developed by the applicants to the treatment of rare diseases are hallmarks of the network getradi brings together strong industrial beneficiaries astrazeneca miltenyi biotec supervising 3 esr highly innovative academic beneficiaries supervising 7 esr 3 additional industrial partners and 4 student enrolling universities professional outreach training with access to widely used social media channels will be provided by the partner european consortium for communicating gene and cell therapy information complementary unique expertise that is spread efficiently by networkwide training and secondments excellent quality of supervision and intersectoral interactions innovative transferable skill training and efficient consortium management will result in an exceptional training of future leaders in gene therapy of rare diseases
entrainment and production in children with dyslexia

dyslexia is often thought of as a deficit that causes someone to transpose letters within a word or to see letters backwards however decades of research have shown that people with dyslexia do not have issues with seeing letters but rather with how they process the sounds associated with these letters the purpose of the current project is to broaden our understanding of the underlying deficits in dyslexia and to identify clinical markers that can help with early identification most studies have focused on how individuals with dyslexia perceive speech sounds using behavioral or neurophysiological paradigms however little is known about speech production ability in this population therefore there is a critical need to examine production in this population which can later be used as an early diagnostic marker by speech language pathologiststhe current project combines both speech production and neurophysiological paradigms to better understand the underlying sources of dyslexia and to identify new markers associated with reading disorders which we can be implement clinically in the first experiment i examine the relationship between phonological processing skills and speech production in typically developing children this will inform how we can use speech production patterns to identify children at risk of developing dyslexia in the second experiment i examine whether neurophysiological brain data is associated with speech production markers in children with dyslexia this project has important clinical implications on diagnosis and earlier identification of dyslexia
x20 driving deeptech growth

the x20 is a sustainable legacy project of xeurope ict332019 and aims to leverage its predecessors established ecosystem network proven innovation actionstartup europe methodology and learnings to generate a nextgen coordination action mechanism x20 project establishes a framework anchored by external service providers also known in this proposal as industry impact builders the framework will deliver a trifecta of key impact drivers namely i upskill and upscale the future deeptech leaders of europe ii connect and nurture relationships between moderately innovative and highly innovative regions and iii reinforce and contribute to the eic offer the x20 will upskill its beneficiaries by providing needbased custom industryfocused growth services corporatestartup opportunities and pathways to private and public funding the project will distribute 15m in innovation and scaling up services to 50 deeptech startups to increase their individual capacities and enhance their longterm competitiveness the project will establish an x20 impact hub of 350 validated impact builders external service providers able to deliver crossborder services and 75 corporations seeking partnerships with startups finally the project will close with a white paper providing insights into the eu deeptech scene the project will run for 24 months establishing a sustainable collaborative ecosystem across the eu and increasing the delivery of deeptech products to market
a holistic flagship towards the 6g network platform and system to inspire digital transformation for the world to act together in meeting needs in society and ecosystems with novel 6g services

to deliver on our european 6g vision for the 2030s and to tackle opportunities and challenges of increasing magnitude eg sustainability trustworthiness green deal efficiency digital inclusion there is need for a flagship project towards the elaboration of a holistic 6g network platform and system to fill this need hexaxii is proposed with the ambition of being this flagship project and of inspiring the world for digital transformation through novel 6g services hexaxii will work beyond enableroriented research to optimized systemization early validation and proofofconcept work will progress from the 6g key enablers that connect the human physical and digital worlds as explored in hexax to advanced technology readiness levels including key aspects of modules protocols interfaces datahexax ii includes a the provision of advanced refined use cases services and requirements ensuring value for society b the delivery of the 6g platform blueprint which will encompass enhanced connectivity for 6g services mechanisms realizing the networks beyond communications vision sensing computing trustworthy ai efficient network management schemes c the realization of extended validation at system and component level d actions for global impact while assuring strategic autonomy in critical areas for the eu europe is starting from the pole position with 6g research and is leading wireless network technologies today now is the time to leverage our joint research ambition with a flagship project that will lead the rd effort towards endtoend systemization and validation the hexaxii flagship is a unique effort and a holistic vision of a 6g system of integrated technology enablers which accomplish beyond the sum of the parts and of a network beyond communications platform for disruptive economic environmental societal impact these are vital for establishing the european 6g technology leadership
search for the missing unicellular relatives of animals

how animals emerged from their unicellular ancestors remains a major evolutionary question work done on diverse unicellular relatives of animals demonstrated that the unicellular ancestor of animals had a larger repertoire of genes associated with multicellularity than previously thought these include animalspecific genes such as protein tyrosine kinases integrins and brachyury this suggests a latent genetic potential in place at the origin of animals and hints at a much more gradual transition in their emergence however a comparison of extant earlybranching animals and their unicellular relatives still reveals an abrupt difference between protists and the body plans of extant animals this gap could be due to intermediate lineages going extinct or that descendants of key lineages have not been found yet recent dna environmental surveys suggest the latter revealing several novel kingdomlevel lineages that branch close to animals and remain unknown we will not make progress in understanding the origin of animals until we have explored the real diversity of animals closest relatives and isolated the major lineages that remain uncharacterized indeed some of the answers to animal origins that we can not currently address with our taxon sampling are likely hiding in hindsight in those unsampled lineages notably a targeted survey of animal relatives has not been done i propose to do this by exploiting recent developments in longread metabarcoding we will screen different environments and isolate the novel lineages using fixationfree labeling methods we will culture them and get their genomeswe will provide a complete picture of the diversity among animal relatives which will also be relevant to ecologists notably the novel lineages will allow us to address fundamental questions about the origin of animals that cannot be answered with the current taxon sampling including the origin of embryogenesis and spatial cell differentiation
visualizing microbial societies exposing the principles of singlecell phenotypic heterogeneity via massively multiplexed imaging

bacteria are social organisms that interact and coordinate their behaviors to shape our world whereas their clonal populations are genetically identical they contain phenotypically distinct members this diversity provides resilience to unpredictable environmental changes such as antibiotic exposure or nutrient depletion it also facilitates cooperative interactions between different subpopulation via specialization in costly activities such as virulence factor production forming an extended basis for sociality yet the phenotypic landscape in any given species remains largely unexplored due to the technical challenges of profiling individual bacteria particularly in spatially structured biofilms and host tissues recent breakthroughs in microbial singlecell transcriptomics developed by the pi of the current proposal dar et al science 2021 now provide a unique opportunity to illuminate this hidden complexitythis proposal seeks a systematic and experimentally derived view of phenotypic variation we will comparatively study pathogenic and nonpathogenic pseudomonas species in three settings each illuminating distinct core principles of cellcell variability in objective 1 we will focus on freeliving populations building on the massive multiplexing capacity of our method to comprehensively map phenotypic cell states outline their interplay with physiological and environmental factors and study their evolution we will characterize the spatiotemporal dynamics of cell states directly within 3d biofilms in objective 2 and contextualize our results in vivo during infection in objective 3 simultaneously measuring hostandmicrobe spatial expressioncomprehensively studying phenotypic heterogeneity is a critical next step for understanding how microbes survive in complex environments socially interact and subvert their hosts during infection if successfully executed this proposal will shed light on the plasticity that defines microbial li
preterm brainoxygenation and metabolic eusensing feed the brain

prometeus introduces a newparadigm for personalized nutrition of prematurely born neonates in neonatal intensive care unit nicu by developing a groundbreaking technology for realtime adjustment of glucose and nutrients intakes to target neonatal brain needs the brain of a baby born prematurely is highly susceptible to early neonatal injuries that in turn increase the risk for neurodevelopmental disability provision of adequate nutrients and oxygen is essential for proper brain development and growth however current nutritional strategies are unfit to target realtime brain necessities and are driven by prespecified non personalised nutritional charts in the absence of contemporary cotside monitoring of both brain health and metabolic supplies as a consequence sudden changes of brain fuelrequirements cannot be promptly addressed by realtime adjustment of glucose and nutrients provision prometeus will develop a metabolic model of the interaction between the three key brain fuels glucose lactate and betahydroxybutyrate bhb and their effect on regional cerebral blood flow cbf oxygen saturation sto2 and metabolism cmro2 the model will serve to individualize brain nutrition targeting brain health according to the inputs derived from two novel minimally invasive metabolic sensing systems a wearable cap measuring regional cbf sto2 and cmro2 and a subcutaneous miniaturized metabolic sensor for glucose lactate and bhb the system will create a metabolic womb to feed the brain of preterm neonates prometeus will be paralleled by a parentdedicated interface exploiting a purposely developed family adjusted visual language that will inform parents of preterm babies during their nicu admission and stay prometeus will dramatically reduce the risk for prematurityassociated disability in europe and worldwide with a consequent incalculable ethical social and economic impact
stable and efficient alkaline water electrolyzers with zero critical raw materials for pure hydrogen production

the eu hydrogen strategy sets the goal of installing at least 40 gw of renewable h2 electrolysers by 2030 which imposes significant challenges for waterelectrolysis technology although current zerogap alkaline water electrolysis awe has potential for costeffectiveness and scalability it needs further optimization in activity stability and gas crossover to increase efficiency and system lifetimethis project will develop a new class of awe combining proven benefits of classic systems with cuttingedge innovations in materials science catalyst design and process engineering driven by an industrialfeasibility vision a system that is both technically advanced and economically viable for largescale commercial deployment is pursued the proposed innovations include highly efficient and earthabundant twodimensional layered double hydroxides ldh obtained through a starightforward synthetic route offering a sustainable and costeffective alternative to noble metalbased catalysts an innovative technology for upscaling the production of ldh layers by direct growth of catalysts in porous transport electrodes will be implemented and explored on commercial separators the interplay between the substrate catalyst and separator will be thoroughly optimized through the development of triplephase boundary electrodes catalystsupportionomer structures with improved thermomechanical stability a reliable method based on raman spectroscopy will be developed for the precise determination of electrode stability offering an appropriate quality control of great interest both in research and industry the optimal design will be assembled and tested first in single cells of 5 cm then in 25 cm and finally scaled to a 6cell stack of 300 cm to demonstrate a next generation technology with improved performance stability and durability aimed to accelerate the commercial uptake of water electrolysis and turn green h2 into an economically viable solution