Dragon09/odtu_chatbot huggingface dataset:
children of the barbaricum short lives early deaths on the eastern fringes of the roman world

children have vulnerability to morbidity and mortality which in turn influence the social structures around these especially susceptible periods the study of past childhood frailty and survival is still very much relevant today especially for children from the edges this project examines the health status of the sarmatian children from the barbaricumthe area beyond the roman frontier the written sources of classical antiquity paint the sarmatians as nomadic people of the steppes between the ural mountains and don river who migrated west and settled in the carpathian basin and on the great hungarian plain occupying parts of modern romania and hungary for over four hundred years while the greek and roman authors described these populations as skilled equestrian warriors hostile and destructive caught in a cycle of war and peace with the roman empire little is known about the biocultural challenges their children had to face living in the barbaricum during the roman age by utilizing interdisciplinary investigations this project integrates data models and theories from bioarchaeology archaeology palaeoproteomics growth and development and ethnohistory in order to deliver a life course approach to childrens health offer a bioculturally informed perspective on gendered differences in direct and structural violence and reconstruct dietary habits at different life stages as children transition into socially adult roles with the onset of puberty according to the who of the 52 million deaths that still occurred among children 5 years of age in 2020 many were concentrated in vulnerable populations by adopting a life course approach within a biosocial framework the project hopes to highlight how the past can inform the present and hopes to show how work carried on precious ancient tiny bones and teeth could contribute to the global efforts to improve the health and wellbeing of children and adolescents today
growing long distance rna control of neuronal extension

neurons are the longest cells extending axons over distances that can reach four orders of magnitude larger than their cell body diameters how can they achieve such long distance growth after initial engagement with target cells neurons undergo stretchinduced elongation as the nervous system matures with the growth of the organism the molecular mechanisms enabling such prodigious growth are unknown based on strong preliminary evidence we tested the hypothesis that both the initial elongating and later stretchinduced axon growth act via a shared rna localization mechanismvery strikingly we identified a specific subset of polyadenylated repeat element rnas hereby termed growthinducing sines gisines as key growth regulators gisines are induced from ap1 promoterassociated extragenic loci and interact with ribosomal proteins and the axon growth regulating rna binding protein nucleolin in neuronal cytoplasm we will elucidate how this intrinsic mechanism controls neuron growth determining 1 how known elongating growth regulators affect stretchinduced growth 2 how local and global protein synthesis regulate neuron growth control and 3 how growth regulates the gisines and how they regulate different growth modalitieswe will apply a multidisciplinary suite of techniques and approaches to these challenges including a new technology for characterization of nascent proteomes developed inhouse the proposed project will provide groundbreaking and fundamental mechanistic insights on neuronal growth and will establish novel methods that will be widely applicable moreover establishing that a repeat element rna is an intrinsic effector linking ap1 transcription to translation regulation is a breakthrough finding that opens new horizons for cell biology and neuroscience
european union contest for young scientists 2023

the present proposal is relevant to the organization of the 34th edition of european union contest for young scientists eucys to be held in brussels belgium in september 2023 since 1989 eucys has been organised in countries across europe with the aim of promoting science and research in different countries and bringing research and young talents into spotlight in these countries the young scientists also have the chance to meet others with similar abilities and interests and to be guided by some of the most prominent scientists in europe this way eucys seeks to strengthen the efforts made in each participating country to attract young people to careers in science and technology the jeunesses scientifiques de belgique jsb the belgian eucys national organiser shall host eucys 2023 and be responsible for the organisation of the event jsb objective is to take on the great opportunity to welcome the european brightest young scientists in europe the organising committee has built a large experience hosting for 37 years the belgian national exposciences eucys 2016 the milset exposciences europe 2000 and the milset exposciences international 2015 esi2015 event that brought together 1000 participants from 60 different countries it will be a unique opportunity to welcome this prestigious event in brussels the european capital and to interact with all european dimension of the host city and region by activating jsb large network of schools professors and students and as well promoting the vent within the european institutions eucys will contribute to greatly enlarge the impact and visibility of the eu science promotion
green engineering analysis reskilling for unbounded production

the gearup proposal is a comprehensive initiative to revolutionize the manufacturing sector through sustainable practices and advanced technologies the projects central objective is to develop digital tools and methodologies that address recycled materials variability it covers stainless steel aluminum alloys and fiberreinforced plastics for additive manufacturing am it employs simulationdriven approaches for optimizing various am processes including laser beamdirected energy deposition metal laser beam powder bed fusion and fiberreinforced polymer material extrusiongearup also emphasizes environmental conservation by using recycled materials in engineering design significantly reducing virgin resources energy consumption and greenhouse gas emissions the project intends to overcome challenges associated with secondary materials such as performance variability through resilient design and lifecycle environmental impact assessmentmoreover the proposal outlines ambitious objectives for enhancing sustainable product design using innovative simulation and modeling software it also implements the digital product passport initiative and fosters human involvement in advancing circularity and sustainable technology adoption this is done through training and global collaborative networks gearups approach represents a paradigm shift in engineering design focusing on the circular value chain and developing universally adaptable am technologies resilient to material variability this endeavor is expected to directly impact the highperformance consumer products green energy hightech robotics markets the key outcomes arecost savings 25 increased productivity 2050 extended fatigue life 5080 defects reduced 5080 material waste reduced 2530 co2 emissions reduced 2550 reduced quality failures 7090 reduced design time 2050 reduced component weight 2530
novel bipolar membraneelectrode assembly designs for simultaneous co2 capture and reduction

the discovery of efficient technologies for mitigation of the rising co2 level and the associated energy and environmental issues isthe grand challenge of our time electrochemical co2 reduction eco2r is one promising approach to convert co2 into valuableproducts but the practical realization is still limited by material and systemlevel challenges on top of this the pathway to bring co2captured from a point source to an eco2r site involves energyintensive practically difficult intermediate steps often overlooked bythe research community the battlecapco2 project introduces a new pathway to fully integrate co2 capture and co2 reductionco2cr in a unit flow reactor this will be achieved by a unique design of bipolar membraneelectrode assemblies obtained bycoupled 3d printing and photolithography techniques an attempt will be done to elucidate the impact of bpm interfacemorphologies and electrode surface properties on the efficiency of co2cr the conceptual flow reactor design allows forsimultaneous co2 capture in situ regeneration and subsequent electroreduction into useful chemicals presenting an energy efficient and costeffective technological solution the action will broaden the knowledge and expertise of the researcher through highquality research training in the field ofcarbon capture and utilization involving multidisciplinary investigation approaches and intersectoral secondments this will allowhim to expand his professional network with leading scientists in academia and industry from across europe and the globe andacquire key skill sets towards professional independence the project will provide new technological solutions with a significantimpact on the ambitious europan green deal aiming to transform eu into a resourceefficient and competitive economy ensuring aclimateneutral society
a genetic engineering approach for lignification of cell walls from moss to develop novel woodlike biomass

in the current context of climate change transitioning from a petroleumbased economy to more sustainable alternatives is of top priority wood is one of the most abundant renewable resources with established roles in the furniture construction paper and energy sectors because of this demand for wood is increasing as policies around the world promote energy generation from wood risking increased deforestation and exchange of diverse forests for monoculture plantations the industrial applications of wood depend on its composition specifically that of lignin in the secondary cell wall scw although much is known about lignification through extensive research on arabidopsis thaliana and other vascular plants there are still knowledge gaps involving the initiation and control of lignin polymerization that remain to be addressed in order to outline the core set of genes associated with the emergence of ligninin these lines the longterm goal of this proposal is to engineer innovative woodlike biomass by introducing ligninbiosynthetic genes in fastgrowing moss to establish new types of biomaterials potentially reducing the use of wood in certain applications and alleviating increasing pressures on forestsmosses are land plants lacking lignified vascular tissues but have homologous genes to most steps in lignin biosynthesis we hypothesize that the lack of lignin in mosses makes them potential model systems to determine how lignin polymerization and scw formation occur in plantsin this proposal we will systematically transform the model moss physcomitrium patens with genes from vascular plants until canonical lignin is observed in its cell wall the outcomes of this work will pave the way for innovative biomass sources and potentially provide insights into tailoring lignin composition and transferring such knowledge to existing agricultural biomass this approach also promises to become a powerful tool for basic research in the study of lignin
regulatory frictions as spaces of innovation frictions centring the transformative administrative practices of smallscale cultural initiatives as empowering tools to engage with the climate crisis

frictions investigates the substantial gap between european policy commitments for a climateneutral economy and the reality on the ground for small initiatives across europe who are making transformative endeavours for climate action in their own communities but face regulatory systems that do not fit the visionary work they do frictions engages with this impasse at a practical level through the daytoday practice of administration as a place where new innovative procedures relations and ways of thinking about regulation can be imagined and forged the research approach departs from notions of progress and modernity that characterise much of transition discourse to concentrate instead on systems change at the microlevel of habit everyday process and experience with particular focus on procedural spaces and relationships where things often feel stuck drawing on my research practice as an artistactivist working across art business and social fields the research objectives are to 1 unearth illuminate and negotiate the kinds of regulatory frictions that small sustainablyminded organisations regularly encounter and the innovative actions they are already making 2 design creative experiments in administrative practice for how such organisations can prefiguratively navigate complex regulatory systems across different eu jurisdictions and 3 establish new channels procedures and vocabulary to promote innovative administrative practice as a transformative means to strengthen and sustain cultureled innovation for the eus critical ecological transition to achieve these objectives frictions will engage methods from participatory action research and tactical art working collaboratively with 3 exemplary smallscale cultural initiatives nlsihr and establish a new research centre the institute for experiments with business ibex as a platform to continue this work beyond frictions
non binary genius intellectual hermaphroditism and androgyny in spain 18921939

geniuses have fascinated generation after generation whether for their artistic achievements or their political work however what really constitutes genius is a question that remains undetermined though it is associated with a high level of intelligence scholars from the 19th and 20th centuries argued that it took something else to be a genius intellectual hermaphroditism and androgyny were considered key aspects for the development of genius because of the benefits that both male and female traits could have for the equilibrium of the mind this project focuses on the relationships between sex and genius in spain from 1892 to 1939 i will explore how experts conceived sex differences for the explanation of genius and analyse the case of hildegart rodrguez a famous spanish child prodigy who was specifically conceived and raised to become a genius and was later murdered by her own mother there have been studies on genius and child prodigies that worked on the importance of genius for social progress and the lack of women genius this project will go beyond these studies by shedding light on a nonbinary conception of the mind through the approach of intellectual history cultural history and gender studies i will work on three research objectives 1 examine intellectual hermaphroditism or androgyny in the study of sex differences in relation to intelligence 2 discuss how a nonbinary conception of genius contributed to the nature vs nurture debate 3 analyse correspondence and personal writings by hildegart rodrguez overall this project aims to empower women and nonbinary folk by investigating their historical role in the production of scientific knowledgemy strong background in history of psychology particularly in the study of intelligence and the circulation of psychological knowledge combined with my supervisors expertise and the host groups work will ensure the successful implementation of this project
superresolution magnetic correlation microscope

over the past several decades the microelectronics industry has revolutionized nearly every aspect of our lives the evergrowing need for faster and more efficient devices recently emphasized by the extreme computing requirements of artificial intelligence techniques is pushing traditional device architectures to their limits prompting the search for novel physical realization of such devices currently the most promising approach involves magnetic materials as can be witnessed through the recent advent of magnetic memories as well as development of logic devices based on hybrid electronicmagnetic structures and the flow of magnetic charge referred to as spintronicsdespite the tremendous progress achieved the field of spintronics is held back by both fundamental and practical open questions related to issues such as magnetization switching and excitation dynamics effects of magnetic and topological defects and local conductance properties of magnetic devices a major obstacle encountered in addressing these important open questions stems from limited measurement and characterization techniques highresolution sensing of dynamic response and conductance cannot be achieved with existing nearfield toolsi propose a new kind of microscope a farfield superresolution magnetic correlation microscopy platform building upon progress in the field of magnetic microscopy using defects in diamond including our recent results studying chiralmagnetic hybrid devices this unique platform will constitute a leap forward over stateoftheart magnetic sensing techniques it will enable for the first time local nanometer scale magnetic correlation data unattainable by other means i will employ these groundbreaking capabilities to reveal the dynamics related to excitation creation and control in 2d magnetic materials and currentspin conductance leading to breakthrough magnetic device architectures
carbonhydrogen bond activation via a new charge control approach

organic synthesis stands as the beating heart of technological and societal advancement driving breakthroughs in drug discovery agrochemistry materials design and the pursuit of a more sustainable world in a world where ch bonds are the main functional groups available the field of ch functionalisation has experienced exponential growth over the past two decades while stateoftheart methods have led to remarkable achievements they remain confined by the dominance of substratecontrolled reactions driven by directing group logic and by being largely reliant on precious metal catalysts chance proposes to open a new page in ch functionalisation exploiting the emerging concept of charge control as a mode to influence and steer reactivity of ch bonds this will usher in a new logic for ch bond functionalisation where reagent control can address substrates devoid of directing groups and where entirely novel reactions will emerge this will not only reshape our fundamental understanding of ch functionalisation but also yield valuable products for downstream applications given my unique expertise and documented trackrecord of achievements especially in the exploration of outofthebox nonmainstream fields of synthetic chemistry i am in a unique position to lead in the unfolding of this new era
nextgenbiopest next generation biopesticides for the control of the most difficulttomanage pests and pathogens in fruits and vegetables

plant pests and pathogens damage agricultural production and endanger food security their control relies heavily on the use of synthetic insecticides leading to a negative environmental impact developing new methods for pest and pathogen control is therefore essential to safeguard human health and meet the challenge of increasing crop yields while reducing the use of chemical pesticides the overarching objective of the nextgenbiopest project is to meet this need by delivering novel and improved products methods and practices for the rational control of the most difficulttomanage arthropod pests and pathogens with substantially reduced pesticide use the project will provide a new toolkit for plant protection in key vegetable and fruit crops including diagnostics for pest and pathogen identification and incrimination novel biological control agents and methods to augment their performance in the field rnabased pesticides low riskgreen chemicals plant resistance inducers and innovative agronomic and ecological practices these innovations will be integrated with existing approaches to achieve effective environment friendly and sustainable crop protection they will be validated in large field studies with both their efficiency and socioeconomic impact assessed demonstration fields extensive training and modern targeted communication channels will enable the appropriate dissemination and uptake of the outcomes to the stakeholders and end users data protection and commercialization strategies will ensure their exploitation these goals will be achieved by integrating leading institutional and industrial partners with drivers of pest control programs the multidisciplinary and multiactor team will exploit their diverse expertise access to extensive preliminary data and resources and strong networks to meet the project objectives and ensure the knowledge and tools generated deliver economic ecological and societal impact
nextgeneration models for advanced battery electronics

nemo project aims at advancing the state of the art of battery management systems bms by engaging advanced physicsbased and datadriven battery models and state estimation techniques towards achieving this goal the consortium tends to provide efficient software and hardware to handle host process and execute these approaches within highend local processors and cloud computingnemo benefits from a wide range of sensor information acquired at high frequencies in addition to dedicated electrochemical impedance spectroscopy eis sensors which allow for the identification of ongoing electrochemical reactions inside each individual battery cell capable hardware for storing and processing such measurements will be provided by the tier1 members of this industry onboard the consortiumthe availability of such diverse physical information on batteries onboard makes room for developing cuttingedge performance lifetime and safety battery models and state estimators within nemo and validating them on two different bms configurations physicsbased performance model parameters continuously get updated as the battery ages so that performance and safety state indicators maintain the least possible error the datadriven approaches exploit mathematical algorithms to be trained upon the large datasets made available from historical or laboratorygenerated battery information combinations of coupled physicsbased and datadriven approaches are also foreseen to be implemented within nemo as another innovation of the project to propose nextgeneration bmssolutions offered by nemo considerably extend battery life and make the battery system safer within longterm operation since every individual cell is monitored controlled and studied nemos ambitious solutions for stationary and automotive use cases are expected to be validated by industrial partners and to take a considerable share of the market in later years