Dragon09/odtu_chatbot huggingface dataset:
where are the humanities in the medical humanities how comics can improve healthcare training practice and dissemination

the last decade has seen a steady increase in the number of medical schools offering courses in the medical humanities an interdisciplinary field that promotes the study of the humanities in healthcare education as engendering greater awareness in practitioners in training and thereby better healthcare practice and dissemination while research in the field is rapidly developing it problematically remains largely theoretical based on a single case study andor presents humanities scholarship as merely additive to rather than integrated in education it is therefore crucial to comprehensively examine how the medical humanities worksand can workin and through practice this project will critically elaborate the benefits of further integrating the humanities in the medical humanities by examining and expanding the discourse on graphic medicine a flourishing field attentive to the study and production of comics about health and healthcare graphic medicine utilizes theoretical and artistic research practice in productive reciprocal exchange as such it is well suited to evaluate and develop the aims current applications and potential of the medical humanities to positively affect not only healthcare scholars and practitioners but also comics artists patients their families carers and the public through crossnational crosscultural and crosslinguistic analyses of graphic medicine from healthcare education to online information and from individual artistic practices to collaborations between comics artists and healthcare institutions this projects five work packages will offer unprecedented comparisons and unprecedented reach to multiple stakeholders who can use the projects findings for future research in an era of global pandemic and rampant disinformation the importance of improving healthcare training keeping the public informed about healthcare and creating new healthcare knowledge from the perspective of patients cannot be undervalued
targeting long noncoding rnas for novel treatment strategies in vascular diseases

the perception that rnas are passive carriers of genetic information has been overturned due to the diverse targeting abilities and extensive research in rna modification and delivery systems nucleic acidbased therapies have emerged as suitable treatment options for many diseases targeting rnas offers opportunities to modulate numerous cellular processes including those linked to the large portion of undruggable proteins currently approved proteintargeted therapies interact with 700 gene products meaning that only 005 of the human genome is presently utilized for treatment on the contrary a large fraction of the human genome 70 is transcribed into noncoding rnas humans produce more than 15000 long noncoding rnas lncrna with a substantial subset of these likely being druggable via rna interference strategies such as antisense oligonucleotides and sirnas in my current longtx proposal we aim at identifying suitable lncrnas with relevance to vascular disease development and progression to be successful we made sure that we have identified suitable lncrnas by profiling diseased human tissue from patients with carotid artery disease and stroke as well as abdominal aortic aneurysms both diseases are currently being treated with suboptimal surgical interventions and the growing affected patient population would tremendously benefit from novel treatment strategies that enable stabilization of advanced vulnerable atherosclerotic lesions and also limit the risk for acute aortic ruptures and dissections the two lncrnas we have identified in preliminary studies using singlecell bulk and spatial transcriptomics are called crnde and nkila we propose to study these lncrnas in diseaserelevant preclinical in vitro arteriesonchips and in vivo genetically mutated mice and minipigs models with a strong focus on novel local delivery concepts for antisense oligonucleotide inhibitors that sitespecifically target both transcripts
planning for sustainable ocean use in antarctica under global environmental change

planning of marine areas is being developed worldwide to support ocean sustainability however few existing marine spatial planning msp initiatives consider climate change explicitly this is a critical oversight in a rapidly changing worldat the same time no formal msp initiatives are envisioned for antarctica it is the only ocean basin globally without msp under development antarctica is changing rapidly with potential repercussions around the planet particularly for sealevel rise climate regulation and marine ecosystems functioning developing integrated sustainable msp for antarctica is now more fundamental than everexcluding climate effects from msp will lead to plans that are maladaptive and inefficient in sustaining marine ecosystems and their use under change by contrast if designed with climate objectives msp can provide substantial benefits while requiring few tradeoffs efforts must be thus put together to effectively move towards climatesmart msp in antarctica and globallyyet contextual idiosyncrasies political social economic limit the effectiveness of such efforts understanding what challenges hinder the development of climatesmart msp in antarctica and globally and pointing ways to overcome such challenges is key plant will take up for the very first time such critical task it will assess socialecological vulnerabilities build future scenarios support areabased climate action and dynamic solutions conduct governance analyses and foster a paradigm shift on how to plan for sustainability and equity under changeresearch on complex socialecological systems rarely leads to onesize solutions and there is a risk that solutions identified in plant are context specific still plant will inspire nations worldwide to finding pathways and solutions to support ocean sustainability at a time when the latter is firmly established in the international agenda taking a leap forward on this topic is groundbreaking
theory and principles of luminescent organic radical materials for oled and sensor applications

organic luminescent radicals olrs are quite rare emitters demonstrating doubletdoublet fluorescence and having a number of advantages towards practical applications in organic light emitting diodes oleds ratiometric fluorescence sensors and anticounterfeiting labelling the doubletdoublet fluorescence by olrs is a spinallowed process similarly to the common singletsinglet fluorescence but in contrast to closedshell molecules for which bright excited singlet states are higher in energy than dark triplet states the doublet excited states of olrs are always lower in energy than the quartet states that is why the theoretical limit for internal quantum efficiency of olrbased oleds is expected to be 100 and why the quartet excited states in general have not been considered for olrs however recent experimental studies indicate that quartet states of olr emitters indeed can be populated in oleds so reducing their efficiency thus in the current project i aim to develop general theory and principles of olrs in order to involve quartet states into the emission process and to boost the efficiency of oleds beyond stateofart resultsanother challenge for this project is design of olrs for sensor applications most of olrs possess lowlying first excited doublet state that makes them perfect antikasha emitters for which emission occurs from higher excited states something that is rare for closedshell systems but required for ratiometric fluorescence sensors in this project i aim to extend the principles of antikasha emission for olrs to make a breakthrough in stateofart ratiometric detection of radicals finally the special kind of sensing called twostep anticounterfeiting labelling will be developed in this project based on photoresponsive aromatic carbonyls these compounds are environment friendly they can easily generate stable olrs upon uv irradiation that i will utilize for innovative anticounterfeiting application
challenging the stateoftheart of low intensity noise single frequency fiber lasers

the focus of this project is the development of stateoftheart kwclass low noise single frequency sf fiber laser sf lasers operate with a single longitudinal mode emitting quasimonochromatic light with khzclass linewidth and low intensity noise this class of lasers are in great demand for precision timefrequency metrology atom cooling coherent lidar and laser spectroscopy however power scaling sf fiber lasers while maintaining its low noise properties and high beam quality has been a challenge due to the onset of stimulated brillouin scattering sbs and transverse modal instability tmi that disrupt the stable system operation beyond a certain power level known as threshold but highpower 500 w lowintensity noise sf lasers with high beam quality are quintessential for building next generation interferometric gravitational wave detectors gwds and efficient neutral beam injector systems for fusion reactors the current stateoftheart for these systems is limited to 400 w in an allfiber architecture we intend to challenge it by developing kwclass lownoise sf fiber laser by using optimized laser design novel ytterbiumdoped fibers commercial and customized and efficient techniques to suppress the undesirable nonlinear and thermal effects such a system would also be valuable in understanding the dynamics and interplay between sbs and tmi and developing an accurate system model for optimized laser parameters and threshold levels for this we seek to combine the expertise of the applicant roopa prakash in building kwclass narrow linewidth 10 ghz polarizationmaintaining fiber lasers with the expertise of giorgio santarellis group in developing stateoftheart lowintensity noise sf lasers using specialty fibers the interdisciplinary nature of this project will generate advances beyond the stateoftheart not only in the fields involved in its development but also in those where this laser can be applied
fastmas solidstate nmr as a bypass to highmolecularweight proteins in solution

my objective is to establish methodology expanding the detailed characterization and exploitation of backbone dynamics in complex proteins up to 80100 kda monomer molecular weight experimental elucidation of protein motion is imperative for fundamental understanding of enzymatic and regulatory features however with a limit of regularly around 4050 kda maximum total mass the more complex targets of current scientific interest usually evade solution nmr backbone resonance assignment and remain inaccessible for the majority of sophisticated methods for protein dynamics this paradigmatic shortcoming has led to serious limitations in the understanding and exploitation of protein dynamicshere i aim to achieve a twofold expansion of the accessible molecularweight range by an unprecedented hybrid strategy based on the unmatched prospects of 4d and 5d solidstate nmr ssnmr assignment data for a 2x72 kda protein i will establish protondetected higherdimensionality ssnmr methodology as a powerful framework for nmr assignment in an unprecedented size range subsequently developing strategies utilizing ssnmr assignments as a springboard to solution nmr will enable detailed characterization of those targets under closetophysiological conditions this fundamentally new bypass strategy will allow understanding of intramolecular regulatory circuits and coupled motional networks in innumerable previously inaccessible complex proteins with a transformative impact for dynamics in particular allosteric regulation in structural biologyfueled by my role as a key player in revolutionizing solidstate nmr via protondetected fast magicangle spinning nmr methodology my achievements will be paradigmatic for the accessibility and utility of dynamics for the structuredynamicsfunction relationship of proteins and will have widespread consequences for a wide range of structural biology and downstream applications such as pharmacology and biotechnology
hybrid intelligence to monitor promote and analyse transformations in good democracy practices

false rumors fake news or hate speech against vulnerable minorities through social media are becoming one of the main threats against democracies a global strategy against disinformation is crucial as open democratic societies rely on free citizens with the ability to access verifiable information so that they can build their own opinions on different political issues the main scientific objective of hybrids is to provide researchers with the knowledge necessary to design strategies and tools to response to disinformation on the basis of a deep analysis of public discourse there have been interesting advances in the automatic detection of disinformation by making use of natural language processing and new artificial intelligence techniques in the specific field of machine and deep learning however this is a very complex task that requires a high degree of natural language understanding inference and reasoning to improve the strategies to deal with disinformation hybrids will integrate the structured knowledge provided by social and human sciences into natural language processing tools and deep learning algorithms so as to develop new hybrid intelligence systems the concept of hybrid intelligence consists of combining machine and human intelligence to overcome the shortcomings of existing artificial intelligence methods even though hybrid systems are likely to become more and more decisive in the immediate future there are very few experts who can design and develop such systems this is mainly due to the multidisciplinary nature of the hybrid strategy and the difficulty of finding researchers with full training in traditionally separate disciplines such as computer engineering social sciences or linguistics we believe it is time to launch a dn with the necessary requirements to train researchers in hybrid methodologies for their application in social studies with an impact on the sustainability of good democratic practices in europe
exometeorology probing extrasolar atmospheres

the exploration of worlds beyond our solar system aims to answer one of the most fundamental questions are we alone in the universe studying a diverse range of exoplanets is critical for investigating earthlike exoplanets in the longterm as we develop the tools facilities and techniques necessary for understanding their atmospheres in detail advanced telescopes such as the james webb space telescope jwst and 30metre telescopes eg the extremely large telescope elt
the cognitive primers of human culture a comparative approach to the emergence of innovations

a hallmark of human culture is our unsurpassed innovative ability which allowed us to expand into almost all environments on the planet and build the cultural world we inhabit today by identifying the conditions driving innovations across primates we can provide new insight into when and how humans developed this unique culture primers will address this need by adopting a systematic and holistic approach to testing the catalysts of a watershed behaviour in our evolutionary history the ability to make and use sharp stone tools flakes the advent of intentional flakes in the human lineage marks the first clear divergence between animal and human technology with tools to access highvalue calories our ancestors now had the physical and cognitive resources to lay the groundwork for our culture primers will use a triangulation approach to follow the emergence of flaking in appropriate proxy models wild and captive chimpanzees capuchins and macaques objective 1 will define the baseline stone manipulation propensities of these species using novel artificial intelligence coding methods objective 2 will test two other major drivers of innovations exposure and experience an experimental paradigm with inbuilt controls large sample sizes n 350 and longterm testing protocols approx 4 years will be used to empirically evaluate the cognitive and developmental primers of innovations objective 3 will systematically compare primate assemblages to some of the oldest human stone tools allowing for inferences to be made on when cognitive capacities diverged between humans and other primates structural equation models will then determine the relative contributions and interactions between the measured factors by testing three species combining and upscaling experimental paradigms and implementing powerful modelling tools primers will radically enhance our understanding of the conditions required for innovations and with it the primers of human culture
a sensor for autonomous navigation in deep space

the space revolution is expected to become the biggest industry in history during the last decades space exploration has contributed to the development of various technologies ie gps weather predictions solar cells reliable power grid earth observation services that feedback into the economy and improve our lives in 2020 the global space economy was valued at about 4469 b with the advent of deepspace cubesats nanosatellites that disrupted this industry space agencies are planning to launch tens of cubesat in deep space per single launch the number of deepspace probes is bound to thrive yet their growth is unsustainable with current practice humanintheloop operations are particularly relevant for flightrelated procedures in cruise phase the spacecraft position is determined from ground with a consistent involvement of resources and assets it is acknowledged that a sustainable deepspace exploration requires enabling selfdriving spacecraft the sense project forges an autonomous navigation sensor for the selfpositioning of spacecraft in the solar system the project stems from the ercfunded project extrema erccog2019 sense aims to elevate the celestial triangulation method conceived in extrema to a proofofconcept sensor at trl 4 our autonomous navigation sensor nanosense is a disruptive innovation that will change the modus operandi for spacecraft navigation sense will revolutionize the way spacecraft travel in space by cutting the cost of ground control of the whole cruise phase and unlocking the new space mission concept the project follows a suitably devised pathway to cover technical validation activities and assessment of exploitation opportunities sense has raised the interest of leading sectoral players see letters of interest
investigating the impact of risk of automation on health outcomes of employees evidence from germany

the proposed research project aims at contributing to the literature on workrelated determinants of health and innovates previousstudies by investigating the impact of risk of automation proxied by a percentage of routine tasks in the occupation on bothsubjective and objective measures of health of employees by merging survey data from the german socioeconomic panel gsoepwith expert data from berufenet and adopting the methodology proposed by dengler et al 2014 the project addresses thefollowing research questions i to which extend does risk of automation affect health outcomes of german employees ii what arepossible transmission mechanisms behind the health differences of german employees related to risk of automation iii is selectioninto occupations at a higher risk of automation determined by a health status of individualsthe project will have a meaningful impact on society to begin with the scientific community can benefit due to promoting gender specificmultidisciplinary research which adopts methodologies from social sciences eg mediation analysis structural equationmodeling and implements them innovatively in the field of economics in addition the project shows how to use different types ofdata eg surveys expert databases to properly address modern challenges and enrich evidence on established topics furthermorethe project serves as a testing ground for a novel methodology of measuring the risk of automation for a variety of occupationsfrom the economic and societal perspective the project estimates the magnitude of the social costs of digitalization and providesguidance to policymakers and companies to decrease negative spillover effects of technological change on population health lastbut not least the social impact of the project is related to analysing new trends in the development of society and assessing actualthreats for public health due to ongoing digital transformation
strainfree all heusler alloy junctions

spintronics is anticipated to replace current semiconductorbased memories and sensors based on fastoperating times ns and low power consumption pj per readwrite operation the spintronic devices typically consist of a magnetoresistive junction with a free ferromagnetoxide barrier or nonmagnetpinned ferromagnet trilayer and may suffer from edgedomain formation and leakage current through the barrier by further miniaturisation 10 nm in cell diameter to avoid such obstacles antiferromagnetic spintronics has recently been developed by introducing spinorbit torque which can reduce the power consumption by over two orders of magnitude but contain critical raw materials in this transformative project we aim to develop a ferrimagnetic heusleralloy film in which the magnetic properties will be controlled by substituting the constituent element to achieve compensated ferrimagnetism effectively the same as antiferromagnetism sandwiched by weak and strong ferrimagnet in a singlestep deposition this will be achieved based on our heusleralloy database developed recently through existing collaborations the selected alloys without using critical raw materials will be grown by dedicated combinatorial sputtering under low pressure and characterised by conventional structural and magnetic analysis as well as nondestructive imaging we have developed and synchrotronbeam imaging at the paul scherrer institute such atomic engineering can offer a new way for material development for lowpower electronics the simplified growth process for a junction without any interfacial scattering is adoptable for future spintronic devices as will be demonstrated using the 200mmwafer production line at imec by the end of this project hence this proposed project will reveal both fundamental magnetic coupling in a ferrimagnetic alloy and atomic control of the alloy for new growth process which can revolutionalise spintronic device production