Dragon09/odtu_chatbot huggingface dataset:
probing the finelyresolved 100 tev gammaray sky for ultraheavy dark matter

dark100 will shine a light into an underexplored dark matter particle mass range driven by recent theoretical developments both in tools and motivation dark100 will search for dark matter particles between 100 tev and several tens of pev leveraging novel costeffective telescope technology dark100 will deploy an array of telescopes capable of probing dark matter annihilation improving on the sensitivity of currently operating and planned gammaray instruments by an order of magnitude with unprecedented energy and angular resolutiondark100 will build a unique dataset of deep gammaray observations of darkmatterrich astrophysical systems dark matter will potentially be detected or in the event of nondetection limits on its velocityweighted annihilation cross section will be set for a nondetection dark matter will be ruled out for part of the probed mass range and theoretical models constrained for the full probed mass rangethe impact of dark100 will be felt beyond the dark matter community by demonstrating a new gammaray telescope paradigm dark100 will enable a range of possible astrophysical studies with gamma rays above 100 tev including searches for galactic pevatrons and transient events its public data archive will encourage synergy with other gammaray instrumentsdark100 takes advantage of a unique moment in theoretical and technological development that enables its pioneering science goals while the theoretical motivation is fully developed and the technology is welltested the deployment of the dark100 array and collection and interpretation of its observations is an ambitious project that demands the resources of an erc consolidator grant the pis leadership in dark matter searches and gammaray analysis and simulation make her ideally suited to direct this program
living too long republican time in american literature

how do you nurture democracy in a republic today as republics around the world are straining under the pressures of authoritarianism this question becomes almost overwhelmingly urgent in helping to draw the blueprints for united states republicanism thomas jefferson gave his answer in temporal terms the us would remain democratic as long as each generation was given power to repair the constitution to suit their era but also the obligation of handing on that document with the entire republic in a peaceful and timely manner to the next generation this pattern of generational succession which jefferson believed would prevent any one generation from permanently stamping their likeness on the country became essential to nineteenthcentury americans sociopolitical outlook to be a truly democratic republic they believed required living in this new temporal order which has yet to be identified by scholarship and which i am calling republican time the goal of my research project executed under the cosupervision of hlne quanquin and hlne cottet university of lille france is to investigate the relationship between republican time and the workings of democracy in nineteenthcentury america i will accomplish this goal through a program of close reading of american literature informed by theories of political science history race and gender and sexuality
concomitant reversal of adrenal insufficiency and muscle weakness to enhance recovery from prolonged critical illness

sepsis complicated surgery or extensive trauma cause hyperinflammationinduced critical illness which requires vital organ support in an intensive care unit icu in order to avoid imminent death although modern intensive care has reduced mortality a large number of survivors continue to require such supportive care in the icu sometimes for weeks or months once in this prolonged phase typical icuacquired morbidities such as lingering organ failure muscle wasting and weakness and vasopressor and ventilatordependency become the main drivers of poor short and longterm outcome irrespective of the initial diagnosis upon admission research from our group has focused on two of these unresolved problems namely icuacquired muscle weakness and icuacquired adrenal insufficiency for which there is either no treatment or treatment has deleterious offtarget effects that may fuel a vicious circle impairing short and longterm recovery today intensivists see these conditions as two separate pathophysiological entities an assumption we think is false we hypothesize that icuacquired adrenal insufficiency shares upstream underlying mechanisms with icuacquired muscle weakness pathways that are currently unexplored and that can be manipulated with the potential to reverse both problems together we will test this hypothesis via an experimental and a clinical track the proposal starts from a novel controversial idea developed via experiments in a unique clinically relevant and validated mouse model of sepsisinduced critical illness and via the study of human patients and aims to close the loop with a proofofconcept randomized controlled trial our ambition is to identify and test a novel compound or combination of compounds to concomitantly reverse adrenal insufficiency and muscle weakness in prolonged critical illness while avoiding deleterious sideeffects and aiming for synergy reaching this ambitious goal would represent groundbreaking progress
nanomaterials for infrared silicon photonics

printed optoelectronics based on solution processable colloidal semiconductor quantum dots qds can make available a muchneeded small footprint low cost and flexible platform for optical sensing imaging and spectroscopy in the technologically relevant short and midwave infrared ir spectrum 15 m 5 m however while this revolution took place in the visible spectrum and is happening at the side of detection for ir light qd ir light source technology is currently expensive lacking performance and is based on restricted chemical elements moreover final device assemblies have large footprints limiting their functionality in consumer devices requiring large scale deployment in nomiss i will therefore explore a route towards printable ir optoelectronics by developing a new class of solutionprocessable qds based on nonrestricted elements with efficient ir emission i will study both their fundamental ir lightmatter interactions aimed at increasing light emission efficiency and the possibility to incorporate them with smallfootprint photonic integrated circuits pics to this end i will first extend the bottomup chemical synthesis of tunable iiiv inassbp qds next i will study their nonlinear optical properties using a novel ultrafast and broadband ir optical spectroscopy methodology in particular focusing on the fundamental questions related to the qds organicinorganic interface and how to optimize spontaneous stimulated ir emission finally i will develop a framework to combine these materals with silicon based pics to realize cheap smallfootprint ir light sources in particular optically pumped lasers after nomiss the new crossdisciplinary and highimpact field of printable ir optoelectronics will be available to meet these high risk challenges i will lead a multidisciplinary team with experts in nanochemistry nanophysics and nanophotonics engineering
autonomous exploration and extraction of deep mineral deposits

the continuous effort and increased demand of the raw materials are directing the mining companies to excavate minerals at greater depths this trend is challenging the current mining operations and the existing traditional technologies towards the objective to retain profitability while achieving the latest green deal environmental vision and securing human workers safety a key enabler to address these challenges and to foster a sustainable development of the mining industry is the development and deployment of innovative technologies for resource efficient extraction of the eus raw materials as well as near mine exploration of critical raw materials in currently nonextracted ore bodies in existing or abandoned ones persephone is aiming to address these challenges by developing of the pioneering technologies for pushing the limits of eu mining industry and embodiment of autonomous and integrated near mine exploration capability to access deep deposits of critical raw materials through hardtoreach deep and abandoned mines the overall concept and vision of persephone will be achieved by reducing the size of mining machines currently adapted to the human scale and embedding autonomy for riskaware navigation and full digitalization of the extraction process by digital twin creation and key enabling technologies validation at trl 5 additionally persephone is introducing completely novel approaches in online near mine exploration core analysis and overall integration of related data analytics to the mine expansion thus persephone allows to foster green transition by reducing the cost and waste generated from deepmining operations and foster the vision of zero human presence in highly hazardous areas these will allow to achieve persephones overall goal to digitalize and automate extraction value chain by creation of new concepts of energyefficient autonomous drilling machines with advanced perception capabilities for navigation face drilling and core extraction which will enable datadriven digital twin creation and geological modelling for further enhanced decision support and optimal extraction planning
evolution on the nile faunal regionalization and continuity in the pleistocene of sudan

over a century of paleontological investigation in africa has revealed a rich pleistocene fossil record that includes the evolution of hominins and their material cultures however the vast majority of fossil sites are located in the east african rift valley earv and our knowledge is heavily skewed by this geographic bias poor continental geographic sampling means we lack an understanding of faunal regional variations and the role of dispersal and geographic variation in the emergence of modern ecosystems furthermore many have questioned the role of the nile the longest river in the world in promoting faunal and cultural dispersal between subsaharan and north africa and beyond to eurasia for decades such questions have been answered speculatively with little data to stand on paleonile is an ambitious project that will address these major gaps in our knowledge through largescale surveys to reveal a new fossil record from the middle nile river basin in sudan this project will test an overarching hypothesis of pleistocene zoogeographic regionalization in the nile basin with respect to the earv and surrounding areas and will use an interdisciplinary array of paleontological geological geochronological and archaeological approaches to reach its objectives the geographic scale of the project is large and the techniques are cutting edge including highrisk experimental methodologies such as paleobiomolecular recovery and new developments in sedimentary dating paleonile forms the first ever largescale systematic paleontological project to be conducted in sudan where the cenozoic fossil record remains largely undiscovered and its potential overlooked paleonile will generate a new paradigm of zoogeographic dynamics and evolution in the african pleistocene that represents a new synthesis of hydrographic phylogenomic archaeological and paleontological evidence
vital elements and postcolonial moves forensics as the art of paying attention in a mediterranean harbour town

for more than a decade the dead bodies of people who had hoped to cross the mediterranean have been washing ashore on the beaches of zarzis a coastal town in southern tunisia this research program starts out from the question how did these bodies end up herewhile in europe people who are adrift may be seen as evidence of a migration crisis from the african side of the mediterranean they point to the chronic neocolonial depletion of livelihoods to map how life is enduringly made unliveable this program develops the method of forensics as the art of paying attention this method will allow us to trail exemplary vital elementsresources crucial for fostering life and livelihoodand the relations between them our cases include the extraction of phosphate the fishing of sea sponges the cultivation of tomatoes the extraction of water and the leaving behind of industrial wasteto better understand the complexity of and material semiotic relations between vital elements we focus on zarzis as a nodal point this will make it possible for team members to visit each others sites and to work together in a method lab as well as to collaborate with local artists who will help to sensitise us to local concerns in a vital elements atelierthe research program is innovative in three ways it 1 contributes to a decolonial shift of attention from the migration crisis befalling europe to the chronic depletion of life afflicting africa 2 develops the method of forensics as an art of paying attention to ethnographically study the complexity of and the relations between vital elements and the ways they impact on living and dying 3 advances the concept of vital elements for materialities that are active make connections and foster life or spur on death
imaging fear of painful touch unraveling relationships between neural correlates of painrelated fear somatosensory neuroplasticity and sensory impairments in the context of chronic pain

chronic pain affects 20 of people worldwide leading to enormous personal suffering and economic burden a key factor contributing to chronic pain disability that thus far has been neglected is fear of painful touch a core symptom in people with complex regional pain syndrome crps fabric fear of painful touch in the brain in chronic pain is a functional magnetic resonance imaging fmri study using a novel tactile fear conditioning paradigm i will examine the neural correlates of acquisition generalization and extinction of fear of painful touch and interrelationships with somatosensory neuroplasticity and sensory impairments in individuals with crps compared to healthy controls also i will investigate how individual differences in vulnerability and resilience factors can modulate fear learning and how they affect painrelated outcomes this msca project is groundbreaking and can yield novel insights in hypothesized intertwined underlying neural mechanisms of painrelated fear and relations with symptoms i will uniquely and necessarily bridge the gap between different disciplines and pain researchers from physiotherapy neuroscience and psychology fields studying the same complex chronic pain disorder persons with crps endorsed the relevance of this project which provides opportunities to alleviate the crps stigma and improve treatments based on newly gained insights maastricht university and the interdisciplinary outstanding research groups are ideal to perform this fellowship the host developed and pioneered the tactile fear conditioning paradigm this fellowship will provide the exceptional chance to synergistically combine my expertise of chronic pain and quantitative sensory testing with neuroscientific neuroimaging and threatsafetylearning expertise at the host thereby crucially contributing to the establishment of my own independent chronic painbrain research line my career development and sustainable scientific collaborations
from caterpillar to butterfly supporting transformation of dcs in a paediatric oncology network

every year around 600 children in the netherlands get cancer and one in four children dies from this illness more than ten years ago a group of parents and healthcare professionals in the netherlands started working towards one national childrens cancer centre that could accelerate advances in treatment by centralizing all patient care and research in one building those efforts led to the creation of the princess mxima centre for paediatric oncology a unique centre that brings together all the highly complex care and research for children with cancer in the netherlands this concentration and integration of specialized paediatric oncology reflects our mission to provide a cure for every child with cancer while maintaining an optimal quality of life only with innovative research we will be able to improve survival and quality of life for children with cancer our research covers the entire spectrum from fundamental research to expose genetic and molecular characteristics of tumour cells to clinical trials to test improved treatment options and from translational experiments to develop personalized therapy to psychosocial studies that monitor the wellbeing of the whole family collaborations within our center between researchers and clinicians but also partnerships with other institutes nationally and internationally are crucial to reach our goals to contribute to this effort the maximabutterfly programme will train the next generation of multidisciplinary scientists in the field of paediatric oncology for a successful implementation and to achieve a radical change in the society the work needs to be translated to the academic community the industry health policy makers regulatory authorities insurance companies doctors patients patients advocates and the general public therefore a multidisciplinary research team of scientists based in the princess mxima centre are applying for a marie skodowskacurie cofund grant for 28 dcs
temporalities histories and methods of philosophy rethinking the canon of history of philosophy and political thought

temporalities histories and methods of philosophy thime intends to contribute to the studies on the critique of the western canon through specific reflection on the history of philosophy and its political nature the objective is to produce a new methodology of the history of philosophy and political thought to deconstruct and rethink the consolidated canon that determines the way the history of philosophy is taught and studied nowadays the ambition is to produce a method capable of fostering emancipatory practices through the recovery of interrupted histories and neglected legacies of thought challenging the intrinsic limits of the logic of the western canon and encouraging a reformulation of the history of philosophy in inclusive and emancipatory terms through the comparative synthesis of m gueroults g deleuzes l strauss and r kosellecks methods and categories thimes will provide an innovative conceptuality to renew the idea of history of philosophy and challenge the exclusionary nature of the canon it will craft a methodology to investigate the problem of plural temporalities and alternative histories on the specific level of the production of philosophicpolitical concepts this approach will produce a knowledge framework that will detect exclusionary biases and flaws hidden in the assumption of a linear and progressive history of philosophicalpolitical thought in general this framework will be able to unearth and empower philosophicalpolitical possibilities concealed within historical contexts ultimately proposing a politics of the history of philosophy capable of bolstering emancipatory endeavors in contemporary society thimes innovative methodology will result from an original combination of the historicalconceptual method and dialectical method which will make visible the production of concepts and philosophical historiographies as polemical products of sociopolitical historical conjunctures
accelerating the translation of virtual twins towards a personalised management of fatty liver patients

the artemis project aims to consolidate existing computational mechanistic and machinelearning models at different scales to deliver virtual twins embedded in a clinical decision support system cdss the cdss will provide clinically meaningful information to clinicians for a more personalised management of the whole spectrum of metabolic associated fatty liver disease mafld mafld with an estimated prevalence of about 25 goes from an undetected sleeping disease to inflammation hepatitis to fibrosis development cirrhosis andor hepatocellular carcinoma hcc decompensated cirrhosis and hcc being the final stages of the disease however many mafld patients do not die from the liver disease itself but from cardiovascular comorbidities or complicationsthe artemis will contribute to the earlier management of mafld patients by prognosing the development of more advanced forms of the disease and cardiovascular comorbidities promoting active surveillance of patients at risk the system will predict the impact of novel drug treatments or procedures or simply better life habits the system will therefore not only serve as a clinical decision aid tool but also as an educational tool for patients to promote better nutritional and lifestyle behaviorsin more advanced forms of the disease therapeutic interventions include tipps to manage portal hypertension partial hepatectomy partial or complete liver transplant artemis will contribute to predict per or postintervention heart failure building on existing microcirculation hemodynamics modelsthe model developers will benefit from a large distributed patient cohort and data exploration environment to identify patterns in data draw new theories on the liverheart metabolic axis and validate the performance of their models the project includes a proofofconcept feasibility study assessing the utility of the integrated virtual twins and cdss in the clinical context
improving user experience longterm sustainability and services of euopenscreen

euopenscreen euos the distributed european research infrastructure for chemical biology and early drug discovery provides worldclass services in highthroughput compound screening and medicinal chemistry to users from academia and industry as one of the largest openaccess initiative globally euopenscreen plays an increasingly important role in facilitating early stage drug discovery in europe it recently integrated fragmentbased drug discovery and chemoproteomics as two new services but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies to ensure that euos continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research impulse will develop validate and integrate new services in aiml new chemical modalities and innovative diseaserelevant cell models combined with crisprcas9rnaibased genetic screening impulse will work towards the implementation of common operational and data standards to increase data reproducibility and fairness bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in preclinical drug discovery new models for precompetitive drug discovery with industry or charities and growing eric member community will reinforce the sustainability and accessibility of euopenscreen