Dragon09/odtu_chatbot huggingface dataset:
open autonomous programmable cloud apps smart edge sensors

the massive increase in device connectivity and generated data has resulted in the proliferation of intelligent processing services to create insights and exploit data in a multimodal manner currently the most powerful data processing operates in a centralized manner at the cloud which provides the ability to scale and allocate resources on demand and efficiently centralized processing and cloud hosting bound and limit their services and applications to operate in a resource restricted manner relying usually on large single entities to provide i authentication ii data storage iii data processing iv connectivity v vendorlocked environments for development and orchestration this significantly limits the user from its data governance and even identity management similarly existing solutions for edge device authentication require a centralized entity to trust them and authenticate them rendering a nonportable identification paradigm oasees aims to create an open decentralized intelligent programmable edge framework for swarm architectures and applications leveraging the decentralized autonomous organization dao paradigm and integrating humanintheloop hitl processes for efficient decision making the oasees vision is to provide the open tools and secure environments for swarm programming and orchestration for numerous fields in a completely decentralized manner an important aspect in this process is identification and identity management in which oasees targets the implementation of a portable and privacy preserving id federation system for edge devices and services with full compliance and compatibility to gaiax federation and idsa trust directives and specifications this situation solidifies the need for an integrated enabler framework tailored to the edges extreme data processing demands using different edge accelerators ie gpu npu snn and quantum
atomically precise graphenebased nano architectures for gas sensing

the dramatic effect of air contaminants on global health and earths climate change require a reliable realtime monitoring of pollutants for their effective reduction the limitation of existing sensing technologies for this need in terms of production cost fabrication processes miniaturization sensitivity and selectivity push the search for new materials and sensing concepts to address the challenge of ultrasensitive gas sensors in this framework graphene appears as the most promising candidates due to its large surfacetovolume ratio low electronic noise miniaturization capability and costeffectiveness however its semimetallic nature limits its application in the most sensitive fieldeffect transistor fet architecture and its inertness severely limits its selectivity this project aims at overcoming these limitations by developing fet sensors using a new class of graphenebased nanomaterials where sensing units with atomically precise analytespecific functional groups are covalently linked to the transductor channels constituted by a semiconducting graphene backbone the multidisciplinary strategy proposed in this project covers the whole value chain from the synthesis of the nanomaterial to the characterization of the sensing devices by merging synthetic chemistry advanced nanomaterials characterization and device fabrication the proofofconcept of such devices will pave the way towards ultimate 4s sensor performances selectivity sensitivity speed and stability thus having a profound impact on the next generation eu challenges of environmental protection and pollution prevention and control
composite conformal liquid h2 tank

alternative fuels such as hydrogen h2 are seen as playing a central role in a zeroemission future for aviation but the level of penetration for h2 will depend heavily on scientific and technological breakthroughs to overcome the challenges posed by h2 powered aircraft the safe and efficient storage of h2 onboard future aircraft is the essential enabler of h2 technologies and will be one of the most complex aerospace engineering challenges that the industry has ever faced improvements to existing stateoftheart solutions includes a better utilization of the available space for fuel storage adequate insulation techniques to minimize heat leak continued safe operations and a weight reduction through lowweight materials such as thermoset or thermoplastic composites all while addressing those materials inherent challenges permeability microcracking thermal fatigue cocolih2t consortium led by collins aerospace is proposing a disruptive concept focused on reducing the impact of the tanks weight and volume within an aircraft while ensuring system safety cocolih2t will not only develop a safe composite and vacuum insulated lh2 tank for the aviation sector but has the ambition to go beyond by designing and manufacturing a conformal tank through novel fabrication technologies enabling a reduction of more than 60 in production energy consumption at least 50 in production time leading to significantly lower manufacturing costs additionally the proposed structure of the tank based on a multimaterial thermoplastic composite concept is intended to facilitate aircraft structural integration to support overall system weight reduction compared with conventional tank configurations the key challenge that cocolih2t will tackle is the generation of a feasible and affordable design of a conformal variable section boxshape tank while minimizing the boiloff leakages wherever possible cocolih2ts overall system will be demonstrated at trl4 by 2025
probing the cell ion channels with functionalized atomic force microscopy tips and electrodes tested on biomimetic membranes embedding ionophores

the main goal of probioncell is to broaden my expertise by performing stateoftheart scientific research in the fields of applied physics and cell biology by implementing functionalized afm tips with natural andor synthetic ionophores incorporated into biomimetic membranes for electrochemically testing their ability to detect target ions in cellular cultures so that to probe and localize cell membrane ion channels gapjunction and focal adhesion on mouse primary cardiac fibroblast cells advancing the characterization of biological cells allows for a deeper understanding and modeling the physiological behavior of biological tissues with huge potentials in biomedicine for improving the management of cardiovascular diseases and their treatment from a personal perspective this project contributes to my first international mobility which is fundamental for unlocking new career perspectives towards a permanent research position and will be implemented at the national institute of materials physics nimp of bucharestin order to achieve the main goal of probioncell some specific objectives are foreseeno1 membrane synthesis and ionophores incorporation bilipid membranes hydrogels and liposomes will be synthesized and the incorporation of ionophores investigatedo2 functionalization of electrodes and afm tips this objective involves the deposition or bottomup construction of the membrane with embedded ionophores at the surface of electrodes and afm tipso3 development of suitable control healthy and pathological fibroblast cell cultures test the membrane capacity for the detection of target ions by electrochemical methods in the absence and in the presence of inhibitory compounds and localize ion channels gap junctions and focal adhesions by afm
controlling gene expression with synthetic cellpenetrating transcription factors

the overarching goal of syntra is the engineering of synthetic transcription factors stfs that can enter cells and activate or deactivate specific genes traditional drugs target only a small fraction of the human proteome while compounds that can be programmed to target specific genes could address many relevant disease mechanisms right at their basis in aim 1 i will engineer stfs that can 1 bind to any given dna base pair triplet and 2 enter cells to achieve these goals i will develop design rules for preparing minimized helical scaffolds derived from zinc finger protein domains via peptide stapling i will stabilize the structure of these stfs and boost their cell internalization i will use a high throughput combinatorial screening methodology developed by me to optimize the stfs properties in aim 2 i will prepare multimeric stfs consisting of multiple monomeric stfs from aim 1 that can target unique genes within the entire human genome with high specificity i will obtain them with a combination of solidphase and bioconjugation strategies with a hexameric stf recognizing 18 dna base pairs i will target a specific gene promoter and trigger globin production as a promising strategy for sickle cell disease treatment in aim 3 i will use stfs to disrupt cancerrelated liquidliquid phaseseparated transcriptional condensates transcriptional condensates rely on a network between transcription factors dna and coactivators and they play a crucial role in gene transcription with stfs i will displace the oncogenic transcription factor myc from its dna binding site i expect this interference to lead to a condensate disruption and to downregulation of oncogenic mycdependent transcription syntra will deliver powerful and practical synthetic tools for studying and targeting disease mechanisms researchers at the interface of biology and chemistry will use the stfs developed in syntra for basic research and drug development
cultural literacies value in europe

the cultural literacies value in europe clivie project develops and applies a theory of change toc methodology and social return on investment sroi framework to increase our understanding of the value of cultural literacy through artsbased education on social cohesion it will be delivered through four main phases it maps artsbased education within the context of cultural literacy learning across different learning environments and over different stages of a young persons education it evaluates artsbased education to help identify and assess their actual outputs and outcomes it values artsbased education activities through calculating its impact to further contribute to our understanding of the where when what and how young peoples cultural literacies are developed and differentiated in various learning environments and it practices pedagogies through developing an innovative set of practices and materials to support artbased educators to develop social justice and inclusion and improve the lives of young people through collaborative pedagogy it has been designed to meet the three main research outcomes of the work programme topic the toc methodology and sroi framework for cultural literacies will directly increase our understanding of the value of cultural literacy on social cohesion the evidencing of value in artsbased education and the collaborative pedagogy practices in cultural literacy through the cocreation of communities of practice cops and a professional development programme pdp for arts educators will support the targeted commissioning of activities that will increase cultural literacy in europe and the innovative methodology for data gathering and engaging through emotional cartography allows young people to find a voice through more effective initiatives to foster cultural literacy around european cultures
together for riscv technology and applications

tristans overarching aim is to expand mature and industrialize the european riscv ecosystem so that it is able to compete with existing commercial alternatives this will be achieved by leveraging the opensource community to gain in productivity and quality this goal will be achieved by defining a european strategy for riscv based designs including the creation of a repository of industrial quality building blocks to be used for soc designs in different application domains eg automotive industrial etc the tristan approach is holistic covering both electronic design automation tools eda and the full software stack the broad consortium will expose a large number of engineers to riscv technology which will further encourage adoption this ecosystem will ensure a european sovereign alternative to existing industrial players the 3year project fits in the strategy of the european commission to support the digital transformation of all economic and societal sectors and speed up the transition towards a green climate neutral and digital europe this transformation includes the development of new semiconductor components such as processors as these are considered of key importance in retaining technological and digital sovereignty and build on significant prior investments in knowledge generation in this domain development strategies leveraging public research funding that exploit opensource have been shown to boost productivity increase security increase transparency allow better interoperability reduce cost to companies and consumers and avoid vendor lockins the tristan consortium is composed of 46 partners from industry both large industries as well as smes research organizations universities and riscv related industry associations originating from austria belgium finland france germany israel italy the netherlands poland romania turkey and switzerland
mucinasebased innovative therapy to enhance cancer treatment

colorectal carcinoma crc is one of the leading causes of cancer death in women and men crc can be broadly subdivided into adenocarcinomatype and mucinoustype crc characterised by an overproduction of mucin proteins which is the primary component of mucus these mucins form a physical barrier that impedes the accessibility of current crc therapies to their target receptors limiting what would otherwise be promising cancer drugsdr karin strijbis group has discovered a compelling mucinase enzyme that can effectively degrade the mucin barrier preliminary research performed by dr strijbis group revealed this mucinases therapeutic potential to enhance the effectivity of approved anticrc drugs ie antiegfr antibodies and small molecule inhibitors by demonstrating the removal of obstructive mucin proteins and a decrease in crc cell proliferation in mucbite we present nanomucase a novel biological based on the conjugation of this mucinase with a nanobody to selectively target crc tumours for optimal delivery and removal of the mucin barrier during this poc project we will determine the technical and commercial feasibility nanomucase through the following activities 1validate the capabilities of the nanomucase to target crc tumours and reduce mucin interference of anticrc drugs in organoid samples and in vivo2define an ip strategy by performing a thorough ip landscape and patentability analysis3conduct market research to discover potential customersindustrial partners analyse competitors and identify a feasible roadmap to commercialisation4formulate a detailed business case to guide the commercialisation of the nanomucase to penetrate the market and deliver a new therapeutic strategy to benefit crc patients
eit culture creativity business plan 20242025

the european institute of innovation and technology eit has launched the 9th knowledge and innovation community kic dedicated to the cultural and creative sectors and industries ccsi founded in 2023 in cologne with 25 partners from 19 nations eit culture creativity eit cc aims to address the global challenges faced by the ccsi which employs 62 of the european union eu workforce but struggles with skills gaps slow innovation and limited scalability and growtheit cc will be cofunded by the eit potentially for up to 15 years with an initial grant of 25m to support education innovation and business creation its 20242025 business plan bp2425 marks the beginning of a journey towards financial independence this is underpinned by a growing community of members some 350 by 2025 who will invest to innovate in their own sectorsthe partnership aims to create a sustainable ecosystem that promotes competitiveness resilience and longterm economic growth through collaboration it seeks to strengthen industry practices support innovation and encourage environmentally responsible approaches all the while enhancing the overall economic landscape for the future in a partnership with purpose by 2025 eit cc will train 1500 students support more than 90 companies startups scaleups and smes incubate more than 10 startups through our incubation and acceleration programmes it will also implement some 25 innovation projects across various cultural and creative fields architecture audiovisual media fashion cultural heritage and games eit cc will also spearhead efforts to enhance the resilience of the ccsi by developing modular resilience plans for organisations across europe by 2025 60 pioneering stakeholders will be involved in the creation and adoption of these plansultimately eit cc aims to become a holding company by 2027 investing in 50 of europes top cultural and creative businesses the focus is not just on creating a network but on fundamentally transforming the ccsi through facilitating longterm partnerships moving beyond publicly funded projects and turning innovation into impact the goal is to secure a competitive edge for the european ccsi on the global stage while fostering ethical practices the preservation of cultural heritage architectural sustainability and the competitiveness of the european games industry and addressing challenges such as fast fashion and media ethics
social transformation for water stewardship through scaling up citizen science

otters will aim at promoting and scaling up successful citizen science cs initiatives in the marine and freshwater domains via 1 accelerating the cocreation of standards in data collection semantics data quality and data management making sure to abide by all ethical and legal standards 2 promoting and scaling up successful waterrelated cs initiatives by clustering them under codesigned springtosea campaigns to foster agency and increase ocean literacy 3 connecting the citizengenerated data to other eufunded projects and portals including the european marine observation and data network emodnet and digital twins of the ocean iliad to ensure the accessibility and reuse of the data and abide by all fair principles 4 demonstrating the effectiveness of citizen science in participatory research environmental monitoring and changing peoples behaviors to ensure the sustainability of water ecosystems and reach the goals of the eu water framework directive and un decade of the ocean
creating a sustainable functional food chain a pathway to eu climate neutrality and improved health

pathfood aims to revolutionise the field of seleniumenriched functional food aligning with the european unions strategic objectives for sustainable development public health improvement and socioeconomic growth thereby strengthening the university of warsaws uw standing as a leading institution in this research domain it is a conduit for knowledge transfer and capacity building with internationally leading partnersthe project integrates multiple facets from selenium sourcing with robust traceability systems to innovative crop cultivation methods that enhance selenium content while minimising environmental impact additionally the project focuses on optimising food processing techniques to preserve selenium content and develop consumertailored functional food products advanced analytical methods such as highperformance liquid chromatography hplc and highperformance thinlayer chromatography hptlc will be utilised to scrutinise selenium content and its speciation regulatory compliance forms a cornerstone ensuring consumer health and instilling confidence in seleniumenriched food productsadding to these dimensions pathfood is committed to achieving gender and diversity balance within the consortium throughout the projects activities all participating partners established policies gep designed to foster gender equality diversity and inclusion amongst employees enriching the projects social impactfurthermore the project espouses an open science approach aiming to make the research process more transparent and collaborative this will facilitate the sharing of methods data and findings with the broader scientific community thereby accelerating the pace of discovery and ensuring that the research benefits are distributed more widely the collective goal is to advance the frontiers of functional food development and foster global cooperation and innovation in the pursuit of healthier and more sustainable dietary choices
the ebopep project ebola zare postexposure prophylaxis preparedness and efficacy evaluation during outbreak in central and westafrica

ebola virus disease evd outbreaks represent significant threats to public health and require effective countermeasures to minimize transmission and reduce mortalitythe rvsvzebov vaccine ervebo demonstrated efficacy in protecting contacts and contacts of contacts and has since been widely used in ring vaccination strategies in the democratic republic of congo drc outbreaks however its efficacy for highrisk contact is more and more debated furthermore two monoclonal antibodies mabs ansuvimab ebanga and regneb3 inmazeb have demonstrated their efficacy as treatment in reducing mortality in patients with evd with the availability of these management and prevention tools the question of their use in postexposure prophylaxis pep to protect individuals from contracting evd after a highrisk contact is more important than ever to effectively control evdthe ebopep consortium built on a highly successful collaboration between african and european institutions and ngos and allow to maintain a network for knowledge sharing and consortium collaboration to fight against evd in africathe overall objective of the ebopep project is to increase the portfolio of therapeutics tools against evd by evaluating a pep strategy for highrisk contact this will be accomplished through a multiepidemic multicountries phase iii clinical trial to test the efficacy of mabs used as pep during outbreak period to address this objective we focus our activities on 3 specific objectives to set up a multiepidemic multisite and multicountries phase iii clinical trial in africa to test the efficacy of mabs used as pep for evd highrisk contact ebopep study to strengthen the capacities of clinical researchers and increase the knowledge and engagement of the community on evd research to define the best pep strategy for highrisk contact and to advocate for pep implementation in the countries affected by evd