Dragon09/odtu_chatbot huggingface dataset:
a lifechanging pressure sensor system for urodynamics to solve global urinary storage and voiding problems

900 million patients globally suffer from urinary dysfunction setting the right diagnosis and deciding upon the right treatment medication assistive devices rehabilitation andor surgery can sometimes be very challenging todays technology provides a limited 15 min snapshot based on the artificial filling of the bladder there is a clear need for a technology that can provide high resolution accurate and realistic bladder pressure data over time based on natural filling pressuro is a revolutionary micro and nanotechnology pressure sensor system based on more than 10 years of research at sintef the sensor will be inserted directly into the bladder and enable continuous measurement based on natural physiology for up to 30 days this solution will provide a completely new understanding of bladder function and enable better diagnosis and treatment for millions of patients
proteaseguided tumor targeting tools to revolutionize cancer diagnosis and treatment

europe has a high cancer burden in 2020 27 million eu citizens were diagnosed with the disease and 13 million lost their lives to it this toll is expected to increase further mainly because europes population is ageing by 2035 cancer will be the leading cause of death in the eu in 2021 the ec published its europes beating cancer plan ebcp calling for a big push in cancer research cancer diagnostics and therapeutics should rapidly become more effective and selective patientfriendly and personalizedall these goals are directly addressed by developing better tumor targeting strategies typically they consist of equipping diagnostics and therapeutics with a vector unit the vector unit binds to a protein that is overexpressed on cancer cells or in the tumor microenvironment tme causing the diagnostic or therapeutic payload to accumulate in the tumor over the last decades huge effort has gone in approaches that use antibodies as vectors but returnoninvestment has overall been rather poor exciting recent innovations rely on small molecule vectors that target tme proteases proteases are ideal candidates for tumor targeting they are often strongly overexpressed in the tme and possess an active site that allows highaffinity anchoring of vectors members of this consortium have played a leading role in these developmentsoncoprotools wants to force breakthroughs in cancer diagnosis and therapy by1 exploring innovative venues for protease targeting in car t cell therapy 2 discovering novel vectors that bind to other tme proteases cathepsins s b l and granzyme b3 personalize applications of protease targeting deliver innovative diagnostics through deeper understanding of tme biologyat the same time oncoprotools will deliver a training program that truly captures the msca values to 10 doctoral candidates they will be provided with all capabilities to become leaders of tomorrows ri in europe
participation and representation in the digital age participation repertoires in an era of unequal representation

this project addresses the question of how people incorporate increasingly prevalent nonelectoral political acts into individuallevel repertoires of participation and how well represented these different types of political participators are at a time of growing concern about unequal representation in democracies two conflicting global trends over the last several decades highlight the importance of these questions a clear decline in voter turnout especially among lower status groups and evidence of increased nonelectoral participation especially among higher status groups to assess how these trends in political participation affect patterns of representation prds theoretical framework integrates new approaches for investigating the links between individuals participation repertoires ie how individuals combine voting protest online activism and objective and subjective representational outcomesprds work packages employ a multimethod approach political acts and political participators wp1 analyzes separate surveys and a harmonized dataset and includes methodological innovations using new techniques for identifying participation repertoires participationrepresentation connection wp2 investigates the connections between the political acts and political participators analyzed in wp1 and representational outcomes and integrates these findings with qualitative fieldwork with activists who focus on unequal representation finally mobilizing and organizing lowstatus groups wp3 conducts novel experimental studies using twitter panel data and field experiments to identify interventions with the potential to produce more equal representational outcomes in the future by combining an original theoretical framework and methodological innovations prd will conduct a uniquely comprehensive empirical investigation of participation repertoires with a focus on mechanisms that can reduce inequalities in participation and representation
new systemdriven bioremediation of polluted habitats and environment

the objective of nymphe is to develop bioremediationrevitalization strategies based on the assembly of systems of available and new biologics enzymes microorganisms bivalves and earthworms plants and their holobiont developed and applied on matrices from different eu contaminated sites groundwater sediments hyporheic zone wastewater as well as industrial and agricultural soils the assembly of systems is guided using predictive microbial interaction models in the microbiome of the actual site matrix to be decontaminated the best systems of biologics are reintroduced at the contaminated sites 4 plus 1 site for confined tests using genomically edited biologics nymphe target at least 90 removal of the pollutants occurring at the sites eg plastics and pesticides in the agricultural soil and chlorinated solventstotal petroleum hydrocarbon in groundwater and sediments of the industrial site besides biologics and systems benefit from the development of platform technologies to assemble stable consortia adhesincomplementary auxotrophies accelerate the evolution of the microorganisms increase mobility of degradative plasmids genomically edit bacteria to produce evolved enzymes produce enzyme systems with recycling of cofactors control the spatial distribution of biodegraders 3dprinting protect them in harsh environments facilitate redox processes by electromicrobiology design selfsustaining redox biocatalysts the bioremediationrevitalization strategies undergo a full assessment ecological and environmental risk analyses chemical ecotoxicological and supportive analyses eg function and biodiversity of the microbiomes technology risk analysis life cycle assessment life cycle cost costefficiency analysis biosafety regulatory constraints analysis and societal analysis to be finally benchmarked with current solutions the ecological status of the bioremediated sites shall be closer to natura 2000 specifications
lifting design drawings to 3d

building on the outcome of the erc starting grant d3 erc2016stg 714221 the objective of dlift is to demonstrate how our technology for reconstructing drawings in 3d can streamline the computeraideddesign cad workflow and to take the first steps in industrializing this technology drawing is a fundamental tool of product design however while 2d drawings are easily understood by humans they are currently not interpretable by computers to confront their ideas with physical reality designers have to separately create 3d models that form the necessary input for digital engineering tools skilled 3d modelers often need several hours to convert a drawing into a 3d model at an hourly rate of 50 euros on average making 3d modeling a major bottleneck that hinders rapid iterations between ideation and prototypingthe erc starting grant d3 aimed at bridging design exploration and design engineering by offering the first algorithm capable of automatically lifting 2d design drawings to 3d the objective of dlift is to optimize our algorithm to integrate it within leading cad software this objective will be achieved through three iterative steps1 feature development based on preliminary discussions with cad users and software editors we have identified a set of key features to unleash the potential of our technology2 user testing we will hire professional designers and 3d modelers to stress test our tool first to make it robust to the diversity and complexity of realworld design drawings but also to assemble a portfolio of artworks that will illustrate diverse ways in which our technology can be used in practice3 transfer within each iteration of feature development and testing we will work handinhand with software companies interested in our technology to assess how it addresses their specific needs we aim at licensing our technology to one or several of these companies such that it can be integrated in their own solutions
development of patient ossicle for the personalized modelling of bonedeveloping cancers and therapeutic testing

cancer is a huge societal concern representing one death out of sixth in 2020 the vast majority of existing cancers emerge or ultimately develop in bones leukemia lung breast prostate kidney bladder our bones are thus considered a privileged harbor for cancer cells and this is also associated with a very poor survival prognostic bonedeveloping cancers account for 3 million deaths each year when at all existing treatments are poorly effective 92 of new therapies successful in preclinical testing fail in clinical trials this urgently calls for the development of models to study cancer and test therapeutics in a more reliable fashion towards this objective we proposed to engineer human minibones in mice in order to mimic the patient bonedeveloping cancer condition these minibones aka human ossicles forming in animals consists in miniaturized bone organs composed of the patient own cells including cancer cells the human ossicles were thus proposed as unique technology to study tumour progression but also test therapeutics in an advanced and personalized in vivo setting however despite substantial promises the human ossicle model suffers from a lack of standardization only 10 of patientderived cells can successfully form human ossicle5 this prevents the large exploitation of hoss as a standard model to study bonedeveloping cancers and establish tailored treatmentswe here propose ossigel as a technology offering the standardized and reproducible formation of human ossicles ossigel consists in a cellsecreted gel which production is ensured by a dedicated human cell line mixing isolated patient cells with ossigel in vitro restore their capacity to form human ossicle by injecting the ossigelpatientcells mixture in the back of mice leads to the successful formation of human ossicle in vivo fig 1 the resulting patientderived bones can then be used to study cancer development and for the personal testingselection of drugs
monitor respiratory health using voice

voice can tell a lot of information about our health we believe that voice is the new blood for medical diagnosisasthma is a longterm disease that affects the lungs and airways it is one of the most common chronic diseases with 58 of the eu population suffering from asthma 30 mill people doctors have always relied on the patients voice as one of the first parameters to assess health when they talk to a patient they carefully listen to their breathing cough and speech looking for specific signs however doctors usually evaluate patients without using any digital solution leading to a 50 rate in nonwellcontrolled patientsdeeptech innovation voicemed uses vocal biomarkers combined with sound analysis and artificial intelligence our technology detects subtle signals in the sounds produced by the vocal apparatus when the association between a signal either a normal biological or pathogenic state is fully validated these signals become vocal biomarkers this process allows going beyond the sounds routinely used in medical practice such as wheezes or crackles and unlocking a new dimension of biomarkers that can be assessed remotely instantaneously and with no extra equipmentwomen foundersarianna arienzo ceo 6 years experience in business in 5 countries including silicon valley entrepreneur in digital health and digital technologies listed in forbes under 30 in 2022 contract professor at cattolica university in healthcare innovation msc business administrationdr ayana de brito cso 9 years experience as a research scientist in computational biology currently leading our research team she has skills in scientific practices scientific writing pm strategic planning data analysis statistics data visualization and programming she is an expert also in regulatory affairs with knowledge also in privacy phd in computational biologist
georadaraided highresolution exploration to advance deep geothermal energy usage

geoheat will transform geothermal exploration through two key strategic shifts i minimising predrilling exploration costs while quantifying and communicating the risks and ii maximising learning rates of exploration drilling while reducing the costs of characterisation as a first step the high costs and shortsighted prospection are tackled with passive surfacebased imaging methods and uncertainty encompassing modelling alternatives in parallel to reducing measurement bias our approach engages a larger population and stakeholder group in search for optimal locations for geothermal exploitation in the following step geoheat illuminates the subsurface to an unprecedented extent through a novel georadar probe the georadar imaging is complemented with drillinginduced microseismicity monitoring and digital rock physics models to create a highresolution understanding of the reservoir our novel multiscale approach unlocks the potential of informed deviated drilling optimal wellbore placement and accurate performance and risk analysis throughout the geoheat journey we propose effective and inclusive tools for public engagement and twoway communication while we introduce advanced decisionmaking tools for policymakers based on probabilistic modelling and uncertainty quantification to maximize its impact and expediate its success geoheat consists of a complementary consortium with european leaders in the scientific industrial and public domain the interdisciplinarity of our team allows us to look at geothermal energy exploration from different angles eg geophysics engineering seismology social sciences and humanities and ensure the technical scientific economic and social sustainability of our proposed exploration workflow by building on the results and expertise of previous and ongoing related projects geoheat contributes to the europeanwide energy transition process to provide reliable secure and competitive geothermal energy supply
solidstate cooling technology for cryogenic devices

temperatures below 1 kelvin are highly beneficial if not prerequisite to several important technologies that are key to development in present and upcoming decades examples include superconducting electronics such as xray calorimeters qubits singlephoton detectors and rf amplifiers in spite of the typically small size of the elements to be refrigerated the techniques commonly used to access subkelvin temperatures are expensive and cumbersome due to intrinsic need of circulating the rare 3he cryogen or the heavy magnets required for their refrigeration these limitations have been an obstacle to broadscale deployment of subkelvin electronics and photonicshere we develop an extremely compact and fully electrical general purpose solidstate refrigerator able to continuously cool electronic and photonic devices from above 1 k to below 100 mk without any need of thermodynamic cycles based on 3he cryogenic fluid or magnetic fields our approach is based on a recent technological discovery which showed that superconductive tunnel junctions can in fact operate similarly as vacuum isolated thermionic coolers this approach provides full scalability for the total cooling power and ability to create large temperature drops with cryogenic electrical coolers features not available before we follow this approach and engineer a 3d stacked multichip cooler system we capitalize on several of our previous milestones and aim to demonstrate a complete cooler system that can reach performance comparable with dilution refrigeration without need of 3he and at a fraction of the mass and costour vision entails new application avenues in the fields of quantum technology material analysis and surveying radiation detection cosmology and astronomy we expect significant impact for airborne or spaceoriented applications because of the breakthrough reduction in payload mass and complexity allowed by our cooling solution
nonstationary nonhomogeneous turbulence

a wide range of radical technological breakthroughs are needed across all industries and engineering because of the dramatic current climatic environmental and population growth constraints on energy energy efficiency polution and emissions turbulent flows are a key limiting factor in a vast range of these industries including the aeronautical automotive chemical pharmaceutical and environmental engineering industries to name but a few stepchange technological innovations in these industries therefore require rapid and reliable turbulent flow prediction methods which are currently unavailable the stalemate in turbulence prediction methods reflects an 80year stalemate in our fundamental understanding of turbulent flows the past 5 years however have seen a number of advances which overturn cornerstone turbulence textbook material and create an unprecedented opportunity for a potentially decisive breakthrough in our fundamental and general understanding of turbulent flows which are typically nonstationary andor nonhomogeneous these recent advances concern nonstationarity and nonhomogeneity in fundamental ways and open new research opportunities with many new questions and hypotheses this project will seize these new research opportunities with a combination of laboratory computational and theoretical methods and approaches applied to a variety of turbulent flows the expected outcome is a transformative entirely new and extensive fundamental understanding and theory of nonstationary andor nonhomogeneous turbulence and a consequent road map for future disruptive turbulent flow prediction methods
ecological solutions for recovery of secondary raw materials from postconsumer fibreboards

the goal of ecorefibre is to develop and demonstrate innovative demos for environmentally sound and commercially viable recycling of endoflife fibreboards which currently have no commercially viable recycling methods the quantities of fibreboard waste are growing exponentially in line with the growth in production capacity and it is highly likely that more than 60 million tons of fibreboard waste have been created in europe the last 5 years this has caught the european recycling sector offguard ecorefibre is crucial to europes woodbased panel and wood recycling sectors because of various interlinked market challenges of the current situation for creating secondary materials from wood waste ecorefibre builds a strong paneuropean consortium bringing together leading research institutes companies and european associations who will develop and demonstrate a range of recycling technologies for waste fibreboard validation and demonstration of the technologies will take place in an operational environment as system prototypes trl7 or in the relevant industrial environment trl6 these include a sorting line that is able to efficiently sort postconsumer wood waste extraction technologies for secondary materials calibrated wood fines and wood fibres from the sorted waste fractions and conversion to valuable products ie various fibreboard and insulation products particleboard and novel biocomposites as a major impact the secondary fibres will substitute up to 25 of the virgin fibres currently used in the manufacture of new fibreboard the economic viability of the technologies is achieved through a synergistic circular economy approach that exploits multiple valorisation pathways of secondary raw materials the novel fibreboard recycling technologies are transferrable and exploitable for many other biobased industries environmental and social impacts and benefits are integrated into a life cycle perspective
european framework for advanced medical technology evaluation and followup

the medical devices regulation mdr and in vitro diagnostic medical devices regulation ivdr have been introduced replacing previous md and ivd directives to strengthen the eu regulatory framework ensuring the highest levels of patient safety and smooth functioning of the single market for these products yet this regulatory update comes with challenges arising from the increased regulatory burden and strain across various actors in the eu healthtech value chainto overcome these hurdles in eu4medtech we will cocreate with an apriori established stakeholder forum and validate eu4medtech framework a versatile and life cycleoriented set of methodological approaches standardised models and multidomain criteria for the generation and evaluation of clinical and performance evidence of highrisk innovative mds and ivds across prepostmarket stages an interactive cloudbased digital platform will be designed and developed to operationalise eu4medtech framework the latter will include further features such as a regulatory communication channel a global regulatory search feature a user training feature for eudamed stakeholders and a repository eu4medtech framework and recommendations for new common specifications once integrated into the digital platform will be evaluated within 3 different use cases ucs uc1 will focus on class iii and implantable mds uc2 will target class cd ivds whereas uc3 will focus on md and ivd software mdswivdsw and other highly innovative devices 3 clinical studies will be performed in the context of uc3 similarly the digital platform will be evaluated through a proofofconcept poc study key medtech stakeholders will be engaged in codesign throughout the project activities a comprehensive exploitation roadmap will be developed to ensure that project results are widely and equitably adopted scalable and sustainable