Dragon09/odtu_chatbot huggingface dataset:
a european training program to foster the full therapeutic potential of antisense technology across tissues

the effect doctoral training dn network responds to the evolving landscape of rnabased therapeutics and in particular antisense oligonucleotides aso over the last 25 years only 21 antisense nucleic acidbased molecules have been approved by the fda orand ema however the field is now at the tipping point of maturity to achieve regular translation from bench to bed side provided that certain obstacles are successfully addressed our consortium involves experts from academia industry and nonprofit organizations across nine european countries with firsthand experience in the successful translation of this new technology and indepth knowledge of the remaining hurdles for its success with leading scientists at different career stages effects core is form by nine academic and three industrial partners effects objectives include addressing tissuespecific delivery challenges imparting knowledge on diverse aso modalities and creating a roadmap for aso therapeutics in europe the networks composition leverages over 20 years of experience in nucleic acid drug development and was born from the successful cost action delivery of antisense rna therapeutics darter the effect training network ensures a comprehensive education for doctoral candidates through knowledge exchange secondments research workshops and dissemination this network is expanded with the collaborations of experts in communication intellectual property and open science that will train the dcs in good scientific practices by addressing training gaps and fostering collaborations effect is poised to deliver the next generation of experts in this upand coming field elevating europes visibility and competitiveness in antisense rna therapeutics
photosynthetic electron focusing technology for direct efficient biohydrogen production from solar energy

we propose a disruptive technology based on synthetic biology we call photosynthetic electron focusing for the efficient production of hydrogen using lowcost photosynthetic bacteria cyanobacteria genetically reengineered to exclusively direct the solar energy to hydrogen through the development of new highefficiency largescale photobioreactors we will obtain an unprecedented increase in the energy efficiency up to tenfold higher than current approaches our theoretical estimates for the production costs could be as low as 5kg of h2 making our technology potentially comparable to current photovoltaic coupled to electrolysis our bacteria could be adapted and grown in sea water and wastewater moreover it would not require using critical raw materials or toxic processes our biological route involves using fermentationlike technologies with expertise available in many sectors such as the food industry it will also employ contained bioreactors constructed with simple fabrication technologies which are decreasing in cost eg the cost of 3d printing materials is decreasing much faster than the cost of microfabrication we will validate our engineered cyanobacterium in a custom 1300 l photobioreactor which will be able to produce validated innovative green h2 production technology this proofofconcept production will be located in a hydrogen industrial stakeholder to ensure the largescale relevance of our production
static and dynamic aproaches a unified framework for predicting quantum yields of excited state processes

light is at the heart of many critical processes from photontoenergy conversion to photosynthesis common among those fields is that upon excitation a molecule has to release energy to return to the ground state however deciphering how molecules release this energy is a complex puzzle involving navigating a maze of all the possible deactivation pathways as more excited states and photoproducts are involved this puzzle becomes more intricate all these pathways compete and the excitedstate decay rates dictate the entire photochemistry of the system to advance lightrelated applications we must unravel and map these possibilities for the same system we could have thermally and nonthermally equilibrated processes taking place as well as competing processes spawning from a few femtoseconds up to seconds thus encompassing this entire spectrum of processes remains a formidable challenge in computational chemistry demanding radically different approaches the static and dynamic approaches in this project i face this challenge by combining diverse strategies for computing decay rate constants in excited states the overarching objective is constructing a unified framework that seamlessly merges static and dynamic methodologies this integration will enable predictions of crucial parameters like fluorescence quantum yields and lifetimes the roadmap to success involves the development of two distinct protocols in the integratedbased protocol i will combine excitedstate decay rate theories and nonadiabatic dynamics to accurately compute individual decay rate constants in the independentbased protocol i will explore the independent utilization of static and dynamic approaches to compute rates independently subsequently synthesizing these data to understand photochemical behavior this proposal is poised to revolutionize our comprehension of photochemical processes transcending the boundaries of current stateoftheart methodologies
systematic autonomous remote surveying of underwater cultural heritage monuments and artefacts using nondestructive costeffective and transportable digital solutions

the proposition in this project is to use autonomous platforms for remote monitoring and chemical mapping of underwater heritage sites such as auvs autonomous underwater vehicles buoys unmanned surface vehicles and rovs remote operated vehicles a swarm of selfcoordinated auvs will be responsible to monitor survey and scan the heritage sites for detectingidentifying and monitor degradation state of the uw surrounding site possible intervention actions for alarming conditions etc the swarm of auvs will embed high edge processing capacity to support operational autonomy dynamic path planning dynamic samplestrategy planning and coordinatedswarming towards overall low energy consumption and long mission endurance according to the project mission goals the proposed swarming concept foresees building common underwater consensus of the cultural site through periodic bilateral communication between auvs to mutually achieve the overall common surveying goal while the mother buoy will be responsible to collect and deeply analyze raw auv information to provide enhanced site situation awareness insights to the external human supervisoruser furthermore the buoy will be equipped with renewable solar collectors to ensure continuous power availability and reduced missions footprint enough to support the overall mission energy needs auv will be periodically powered through buoy the supervisoruser will be located in a remote monitoring station onshore to allow periodic mission lifecycle management and general overview of the whole system situation based on realtime visual analytic mechanisms
philosophical foundations of criminal law in the age of robots

robots are made to serve humans in carrying out tasks that are hard dangerous or repetitive as well as for entertainment despite their generally benign objectives robots may promote harmful outcomes that are under the radar of criminal law one of the main aims of criminal law is to stabilize society if something wrong is done the law provides ways of responding to it the situation could be complicated by the wider application of robots in social life not only do they disrupt the practice of law they also have the potential to challenge its very foundations the main aim of the robocrim project is to build a philosophical ground for criminal law that accommodates robots i will ask how can the philosophical foundations of criminal law be reconstructed to accommodate robots instead of how to accommodate robots into criminal law which is the usual formulation this shifts the approach to the discussion on robots and their alignment with law and social life the project will be conducted within three interrelated work streams the first stream will be devoted to robots and their status from the perspective of the philosophy of criminal law the second stream will focus on the foundation of a new account of criminal law which i call the phenomenological account the emphasis in the third stream will be on building models of institutions that accommodate robots within criminal law to be tested using experimental methods these new models of criminal response to crimes committed by robots treat robots as initiators of events that require a response from criminal law rather than as individual agents that could be responsible for their actions this combined with a novel account of criminal law makes the project groundbreaking it is interdisciplinary employs multiple methods and will shed new light on how robots might better fit into society in general and criminal law in particular
strong lightmatter coupled ultrafast and nonlinear quantum semiconductor devices

this project will combine for the first time strong lightmatter coupling in quantumconfined electronic systems with the optical and electronic nonlinearities of semiconductor heterostructures we will develop device concepts with unique ultrafast nonlinear and quantum functionalities the key ingredient is an unconventional use of the strong lightmatter coupling regime scr a fascinating concept that is recently transitioning from basic physics to quantum deviceswe will first address fundamental physics problems then well turn to device applications a key conceptual building block is that the nature of optical nonlinearities is radically modified when operating in the scr this has profound consequences we will study fewphoton nonlinearities in particular the ultimate case of devices that can sense virtual photons this will lead us to device concepts whose behavior is enabled by vacuumfield photons bringing us radically beyond the state of art we will then move to the case of many photons we will focus on absorption saturation that explored only in the weak coupling regime where it is difficult to engineer we have discovered that in the scr instead it becomes tailorable and previously unavailable functionalities can be envisioned this has profound consequences we will demonstrate semiconductor saturable absorber mirrors sesam for the midir spectral range a technology that revolutionized ultrafast lasers in the nearir but is missing at longer wavelengths we will apply them to fiber and interband cascade lasers radically advancing the potential of those sources these are groundbreaking demonstrations for midir science and technology smartqdev is a project rooted in fundamental physics research able to open up new horizons and research opportunities on longerterm and visionary topics at the same time smartqdev has a clear vision for applications
metabolic immunoengineered biomaterials

large bone defects display compromised healing associated with pronounced inflammation and constitute a major clinical problemrecently a range of novel biomaterialbased approaches have been engineered to promote bone regeneration however once theseconstructs are implanted they encounter the harsh environment of damaged tissue and often fail to induce a regenerative responsewith this msca postdoctoral fellowship i will address the clinical problem of large bone defect repair by harnessing extracellularvesicles evs derived from metabolically modulated macrophages to promote the immunogenic angiogenic and osteogenicresponse in the longterm healing cascade specifically my research goal is to generate an immunoengineered scaffold with thesemultitargeted regenerative evs to maximise bone repair the proposed multidisciplinary project will be carried out in the tissueengineering research group terg at the royal college of surgeons in ireland rcsi which is a leading partner in the sciencefoundation ireland sfi funded advanced materials and bioengineering research centre amber under the supervision of profannie curtis additionally as part of my project training plan i will carry out a secondment in trinity college dublin under thesupervision of prof david hoey gaining expertise in materials for bone regeneration at the end of the fellowship with my nonacademic placement at tamirna a biotech company specialising in diagnostic and therapeutic mirnas i will investigate the smallrnacargo of the proregenerative evs for the identification of new specific therapeutic targets metabolate is a unique opportunityto acquire advanced research competencies and complementary skills through interdisciplinary and intersectoral training this willallow me to mature as an independent scientist and to enrich my professional profile preparing me for a multitude of career choices
science building the future

science plays a major role in the development of a society despite this the general population of romania has little knowledge about the impact of research on all aspects of life in this context events that advertise science among the general public are very welcome another strong argument in favor of organizing the science popularization event is that this kind of events usually take place in major cities while in small and medium towns they are very rare so their population is missing the opportunity to discover science from a different perspective in turn this lack of information facilitates the occurrence of stereotypes about scientists and their work and about the usefulness of scientific research which ultimately discourages young people to pursue a career in rd the main concept proposed for 20242025 is to reduce the passive presentation of what means to be a researcher by involving the people directly in different interactive activities workshops games competition debates etc the project is constructed around four basic ideas future through past health and wealth through a clean environment economic development through technology and innovation science for future research begins at school an important objective is also the future utilization of information gathered during the event in order to enable cooperation between relevant actors that are committed to support scientific collaboration that may generate new opportunities for research and industry and new knowledge and know how that can be shared by confronting new ideas and viewpoints regarding the audience the dissemination strategy will be directed towards various user groups such as the general public especially young people the scientific community public institutions ngos policymakers various associations businesses etc the partners have the complementary skills to assure the achievement of the project objectives and the future exploitation of the results
preclinical in vivo proofofconcept for cyclic oligopeptide rescuers of pathogenic protein misfolding and aggregation associated with neurodegeneration

within the erc consolidator grant promidis my team and i have developed genetically engineered bacteria that function as a standalone living discovery platform for short druglike cyclic peptides rescuing the misfolding and aggregation of proteins associated with human diseases protein misfolding diseases pmds by applying this technology we have discovered hundreds of new moleculesputative drugs against notorious pmds such as alzheimers disease and amyotrophic lateral sclerosis als we have filed patent applications for aspects of this technology and for the first set of bioactive molecules in poc4promis we will demonstrate in vivo proofofconcept for the most promising molecules targeting the devastating neurodegenerative disease als to achieve this we will first develop an optimized method for efficient delivery of cyclic peptides to the central nervous system cns by utilizing a novel specialized cns delivery vehicle then we will evaluate the effectiveness of our lead molecules to reverse disease phenotypes in wellestablished als mouse models finally we will explore opportunities to strengthen further our ip portfolio by patentprotecting our sod1targeting cyclic peptides with additional claims relating to methodofuse and mode of delivery poc4promis will demonstrate in vivo poc and will provide a general approach for efficient cns delivery of cyclic peptide drugs targeting additional neurodegenerative diseases of high priority for drug development
haptic tablet for the accessibility of digital content to the visually impaired

digital technologies have become pervasive in our daily lives and have fundamentally changed the ways we communicate and interact with information and with each other we now have access to digital content anytime anywhere and in a palette of formats ranging from images videos text speech to virtual and augmented reality experiences typically this has made smartphones and similar mobile devices an invaluable source of information and a mean of connection to the world and to others yet by relying almost exclusively on visual and auditory feedbacks these devices pose evident accessibility issues current smartphones and tablets provide accessibility features but mostly in the form of texttospeech which can be impractical and affect literacy and through connectivity to refreshable braille displays which involve an additional peripheral often bulky and expensive or when small too limited these devices still prevent the visually impaired access to graphical content and complex notations a solution would be to develop a specific tablet for the visually impaired but few of them exist and currently tackle all these challenges in ability this will be achieved by proposing a novel costeffective actuation mechanism for multiline braille display relying on fewer and remote actuators able to control independently the braille cells and a tablet with innovative multitouch vibrotactile localised feedbacks this device will provide multisensory interactions and feedback leveraging ai algorithms for device adaptability to the users needs and behaviour for image analysis and predictive writing the goal is to provide a multisensory device covering the wide range of visual disabilities and needs of the visually impaired population through combinations of tactile visual and auditory feedbacks for this ability will adopt a usercentred design approach throughout the project to involve the users iteratively in the different design and evaluation stages
next advanced biofuels from algae biomass and organic biogenic wastes for electricity generation through fuel cells application

niagaras project intends to make a significant contribution to the development of a sustainable process chain involving the shaping and procurement of openly available eu biogenic wastes wastewaters digestate sewage sludge etc a production of carbohydraterich microalgae an innovative continuous and flexible htc process to convert the mix of biogenic wastes and microalgae into a solid fraction hydrochar and an aqueous phase that will in turn be converted into an advanced biofuel a biogenic syngas rich in hydrogen via gasification and aqueous phase reforming subsequent syngas cleaning processes are envisaged to ensure a full compatibility of the syngas to the solid oxide fuel cells niagaras value chain will feature a very low carbon balance with a strong potential to become carbon negative overtimeniagara will dramatically improve advanced biofuel production by combining complementary scientific and industrial knowhow while fostering various promising market applications eg fuel cells the niagara methodology which derives from the ambitious idea of producing advanced biofuels from euwidely available biomasses and wastes on a fully circular basis making this value chain ultimately sustainable the main market application that is sought in the niagara project is the generation of electricity using highly efficient sofc this implies i individually developing key innovative and carbonefficient processes ii assessing their performances carbon footprints energy balance and production yields and iii demonstrating their integration and global compatibility to reach the objective of negative carbon emission on the biofuel production chain up to the generation of electricityniagara will contribute towards lowering the technological economic and social barriers faced by the development of the contemplated processes at trl5 the outcome of this work will contribute directly and significantly to eus overall renewal energy targets
rites of passage and monastic communities in the lateantique mediterranean

how did medieval monastic leaders assert control over their communities this project proposes an innovative way to approach to this oftenconsidered question through the rites of passage into ascetic groups in late antiquity fourthseventh centuries ce lateantique sources emphasise five membership rituals as particularly significant rigorous testing ceremonial cleansing the offering of stability pledges the renunciation of possessions and the donning of uniform attire these rites were meant to bind novices to their new lives efface their prior identities and enforce obligation to their abbots and abbesses although the scholarship on medieval monasticism is extensive the relationship between ascetic authority structures and the aforementioned five ceremonies has received little recent substantial attention this project proposes to investigate this relationship from the first appearance of monastic groups in the fourth century to their widespread multiplication across the mediterranean by the seventh century to do so i will focus on laws monastic rules church canons hagiographies and provincial documents five types of source which are not often brought together but represent contemporary attempts to assert control over ascetic rites of passage my research will use a comparative interdisciplinary framework of diachronic transcultural and regional and sociohistorical analysis to achieve the projects three core goals 1 to explore how and why these ceremonies changed 2 to analyse how these rites supported or challenged lateantique discourses about monastic obligations and identities and 3 to investigate how these rituals were related to other analogous rituals and processes furthermore this project will contribute to the increasing scholarly interest in medieval monastic perspectives beyond the benedictine and also pave the way for epistemological reconsiderations of authority identity and obligation even into the modern day