Dragon09/odtu_chatbot huggingface dataset:
nanoscale water a quantum understanding of angstromscale transport

water is a substance that needs no introduction it shapes our blue planet is lifeenabling and scientifically fascinating with a host of anomalous behaviours despite centuries of studies breakthroughs in the last decade have shown that when wwater is an abundant yet exceptional and lifeenabling substance the past decades have seen tremendous progress in our understanding of the many peculiarities of water many of which can be traced to the nature of the interactions between water molecules when confining water to nanometerrange pores and cavities wholly new and unexpected phenomena appear water flows differently in confinement its phase diagram changes drastically and conventional theories break down this is exciting from a scientific perspective but also of great technological importance nanoscale water is fundamental to water purification and desalination where water has to flow through nanopores and for energyrelated processes as a source of protons and hydrogen here we aim for fundamental new scientific insights into water at key length and timescales by bringing together a critical mass of researchers with complementarity skillsets in nanofluidics spectroscopy and theory and simulation we follow a radically new perspective for nanoscale water transport envisioning confined water not only in terms of realspace confinement but also in terms of its collective modes how they couple and resonate with the confining material and its quantum excitations to affect global transport seeing water dynamics in both the real and fourier worlds allows us to naturally address quantum couplings and light matter interactions and their effect at nanoscales this opens a new world of possibilities eg by controlling water motion through finetuning of its excitations quantum engineering of water transport is made possible such views have the potential to enable worldchanging novel technologies in the waterenergy nexus and related fields
cold atom rubidium interferometer in orbit for quantum accelerometry pathfinder mission preparation

the overarching goal of carioqapmp is to prepare the deployment of quantum gravimetersaccelerometers in space within the decade through a quantum pathfinder mission indeed the emergence of quantum sensors offers an opportunity to provide new applications for climate sciences through the improvement of space gravimetry performance hence the mastery of this technology in space is one of the major environmental technological and strategic challenges of the decade three main objectives have been set for the scope and duration of carioqapmp1 to develop an engineering model em of the missions instrument and to increase the trl of the critical subsystems up to 5 complementary eu industrial partners develop the subsystems of the instrument ie physics package laser system microwave source and ground support equipment and increase its trl by assessing the critical technologies in relevant environments excellent institutes bring their quantum expertise for the definition of the em and the mastering of its performance2 to guarantee the adequacy of the hardware development with the future scientific needs through their knowledge of scientific applications leading institutes in geodesy analyse and simulate potential mission scenarios for the quantum pathfinder mission and future postpathfinder scientific missions3 to establish a technical and programmatic roadmap for quantum space gravimetry missions this roadmap will be shared and validated by european stakeholders it ensures the impact maximisation of the projects results through its harmonisation with the european programmatic frameworkcarioqapmp brings together the main players of quantum sensors in europe it gathers unique skills among 16 partners from 5 eu member states including 2 space agencies 8 research organisations and 6 industries as a result carioqapmp will secure the capacities for implementing quantum gravimetersaccelerometers in space within the eu contributing to the eus strategic goal of nondependence and autonomy
three dimensional integrated photonics to revolutionize deep learning

neural networks revolutionize computation and already outperform humans according to many benchmarks they have the potential to transform society and have already influenced google to place artificial intelligence at the core ai first of business strategy governments and policy bodies worldwide focus on neural networkbased computing as a vital future technologydespite the evident promise however current architectures severely lose computational efficiency when applied to large neural networks and scale badly the performance of current neural network hardware is orders of magnitude below what is theoretically possible and the future development of artificial intelligence is therefore in jeopardyi will solve this problem by developing neural network processors using advanced photonic components specifically enabling a breakthrough with threedimensional integrated photonic waveguides to implement a biologically inspired fully parallel and scalable architecture this is not an incremental improvement but rather a completely new and neverexplored approach which will revolutionize neural network hardware based on this technology i will create a fully programmable optical tensor processing unit by interfacing 3d waveguide machzehnder interferometers with a commercial slm the unit will calculate the connection of a neural network with speeds and energy efficiency exceeding the state of the art by two orders of magnitude while programmability makes it widely applicable a second system will go far beyond by implementing fullyfletched and programmable optical neural networks based on 3d waveguides and semiconductor lasersthe proof of principle building blocks of the project are in place and i am recognized as a leading researcher in the field the realisation of this project will unlock doors to scalability cascadability and parallelism and stimulate new research as well as applications in artificial intelligence
copernicus climate change service evolution

the copernicus climate change service evolution cerise project aims to enhance the quality of the c3s reanalysis and seasonal forecast portfolio with a focus on landatmosphere coupling it will support the evolution of c3s by improving the c3s climate reanalysis and seasonal prediction systems and products towards enhanced integrity and coherence of the c3s earth system essential climate variables cerise will develop new and innovative coupled landatmosphere data assimilation approaches and land initialisation techniques to pave the way for the next generations of the c3s reanalysis and seasonal prediction systems these developments will include innovative work on observation operators using artificial intelligence to ensure optimal data fusion integrated in coupled assimilation systems they will enhance the exploitation of earth system observations over land surfaces including from the copernicus sentinels and from the european space agency earth explorer missions moving towards an allsky and allsurface approach cerise research and innovation will bring the c3s tools beyond the stateoftheart in the areas of coupled landatmosphere data assimilation observation operators and land initialisation methodologies cerise will develop diagnostic tools and prediction skill metrics that include integrated hydrological variables to go beyond the traditional skill scores to assess earth system coupled reanalysis and seasonal prediction it will deliver proofofconcept prototypes and demonstrators to demonstrate the feasibility of the integration of the developed approaches in the operational c3s the cerise outputs aim at medium to longterm upgrades of the c3s systems with targeted progressive implementation in the next three years and beyond cerise will improve the quality and consistency of the c3s reanalysis and multisystem seasonal prediction directly addressing the evolving user needs for improved and more consistent c3s earth system products
myokinetic towards innovation

myti myokinetic towards innovation aims at boosting the clinical translation of the technology developed within the erc funded project myki a bidirectional myokinetic implanted interface for natural control of artificial limbs core of the project is an innovative humanmachineinterface for the control of upperlimb prostheses which relies on a multitude of permanent magnets implanted within the residual muscles briefly external electronic components acquire the magnetic field of the magnets retrieve their displacement resulting from muscle contraction and subsequently decode the users intention to control multiple degrees of freedom of the prosthesis in a natural and intuitive way the myki project led to the successful firstinhuman clinical demonstration of the interface one participant received the shortterm sixweek implantation of multiple magnets and was fitted with a selfcontained myokinetic prosthesis in just six weeks the participant achieved performance comparable to those achieved with standardofcare solutions building on the knowhow acquired within myki myti will address the weaknesses uncovered by past research and push forward the advancement of the solution for its adoption into standardofcare settings practically it will address the open challenges related to the longterm usability of the interface to enable extensive longterm clinical trials necessary to validate the technology while laying the foreground for its future commercializationthe translation from research towards innovation will be achieved through three main objectives i the identification of a magnet coating material suitable for chronic applications ii the effective insertion of the magnets inside the muscles through the development of a dedicated surgical injector to be used under ultrasound guidance iii the conduction of an indepth market research and the definition of an ipr strategy aimed at the future technology commercialization
floodingtolerant c2selective co2 reduction electrode based on hydrophobic cuw tandem electrocatalyst

co2 conversion to valueadded monomulticarbon products is an appealing area of research to achieve negative co2 emissions while exploiting co2 as a cbased feedstock the co2 reduction reaction co2rr powered by renewable electricity provides a way to effectively utilize co2 gas diffusion electrode gdebased co2rr reactors significantly increase current density to commercially relevant levels due to thinner mass transport layers that overcome the aqueous systems diffusion constraint nevertheless it is still challenging to achieve highly stable gde especially in high current density operation owing to electrolyte flooding as a consequence of hydrophobicity decline so the gde is the primary driver of co2rrs viability but improving its performance is paramount what sets this proposal apart from previous researches is that we seek to demonstrate a compelling way to reinforce the structure of cubased gdes via the formation of bimetallic structures pursuing tandem effect without using precious metals which enhances the selectivity toward c2 products an improvement in the performance and c2 selectivity is envisaged thanks to the formation of noble metalfree cuw heterostructures for the first time giving rise to heteroatomic reaction sites between oxophilic w and cu atoms to reduce the bonding energy of adsorbed co at the same time flooding is minimized by the obtained hydrophobic surface topology the surface topology endows high surface area with adequate hydrophobicity to the gde to establish an electrodeelectrolyte interface which not only traps more co2 along the hierarchical cuw surface as tandem active sites but also efficiently prevents electrolyte flooding even at high rates fotocers achievements will lead to advancements in cuttingedge industrial co2 to useful c2 products which are essential in achieving the eus environmental targets at an affordable scaleup cost
quartz enrichment enabling nearzero silicon production

the queen project with its strong consortium of participants from eight countries addresses a significant challenge eus heavy reliance on external sources for critical raw materials especially metallurgical silicon mgsi currently over 80 of mgsi vital for hightech applications and eus sustainability ambitions is imported mainly from chinaqueen aims to exploit an underutilized resource quartz sand from european quarries to domestically produce mgsi in a sustainable and efficient way the unique approach combines raw material extraction and refinement with an environmental focus leveraging waste materials in the process this strategy is projected to bolster eus mgsi production capacity foster sectorspecific innovation and advance ecofriendly practicesthe queen projects overall objective is to create an environmentally friendly process for producing metallurgical silicon mgsi from quarry sands with nearzero co2 emissions this transformational approach could turn any eu quartz quarry into a potential mgsi reservoir moreover the technologies developed could be adapted to other materialsthe technical objective is to devise a new mineralogical separation process based on flotation for quarry sands extraction this objective aims to pioneer a more effective and greener alternative process for refining highpurity quartz and potassium feldspars comprising rd and industry stakeholders from mineral separation and mgsi refinement fields the project plans pilot tests at trl 7 queen aims to cover 56 of mgsi eu demand by 2032 by recovering more than 300mt mgsi from sands alongside saving about 232000 mt co2 by substituting coal with cleaner materials like this queen aims to support the eu strategic autonomy and sustainability mirroring its green ambitions
optimising indigoidine production heterogeneity for sustainable microbial blue pigment biosynthesis

the textile industry is a major global contributor to environmental pollution primarily due to the harsh conditions and hazardous chemicals used in fabric pretreatment dyeing and finishing processes1 notably the chemical synthesis of dyes such as indigo best known for its use in jeans manufacturing contributes to this burden with growing demands for clothing and fabrics there is a desperate need for more sustainable alternatives one potential solution is the use of microbial alternatives to indigo with a similar colour spectrum and dying capacity our lab recently engineered a microbial factory for production of blue dyes using the industrially relevant yeast yarrowia lipolytica and we have registered a patent due to promising yields during smallscale fermentation in our latest research to improve production yields we noticed a remarkable difference biosynthesis at the singlecell level with some cells containing tenfold amounts of the pigment building on our recent research funded by the erc starting grant deusbio to understand metabolic singlecell heterogeneity this proposal aims to characterise drivers of production heterogeneity during y lipolytica fermentation furthermore we intend to harness production heterogeneity by engineering stable high producer populations to optimise bioproduction and increase overall yields this research will be pivotal for improving the economic viability of sustainable dye production and for developing an optimized microbial host with broader applications in biomanufacturing processes by establishing a proof of concept poc through this research we anticipate potential collaborations with industrial partners paving the way for the commercialisation of sustainable blue pigment production
negative regulation of inflammatory responses revealed with camelid nanobodies

the innate immune system evokes inflammation to control pathogens or damage sophisticated mechanisms interpret molecular triggers to activate inflammasomes or transcription of proinflammatory genes while numerous autoinflammatory conditions underline the need to control inflammation we still rely on simplistic models to understand its negative regulation i hypothesize that an intricate signaling network interprets information to prevent or downregulate inflammation understanding these so far elusive processes demands radically new cell biology tools which i will develop and apply in deflammation i propose to define signaling hubs that integrate cellular input and coordinate effectors to actively downregulate inflammation where beneficial to the organism to yield unprecedented molecular insights we will apply nanobodies to inhibit protein function manipulate posttranslation modifications and visualize endogenous proteins and their binary interactions i hypothesize that two poorly understood members of the nlr family nlrc3 and nlrx1 act as signaling hubs that coordinate negative regulation of proinflammatory gene expression no such coordinator is known for inflammasomes in objective 1 we will pinpoint how nlrc3 controls inflammation and t cell activity i hypothesize that nlrc3 forms antiinflammatory signalosomes to control the ubiquitination status of proinflammatory signaling components in objective 2 we will reveal how nlrx1 counteracts interferon responses inflammation and proliferation we will explore whether nlrx1 activation coordinates organellespecific autophagy to remove proinflammatory signaling complexes in objective 3 we will identify novel regulatory circuits that control inflammasome activation using crisprcas9 and cdna screens taking advantage of a novel reporter we have developed the anticipated results will reveal entirely new layers of regulation of inflammation with implications for therapeutic interventio
accelerating netzero transformation by advancing europes transport pathways and crosssectoral synergies

transports ghg emissions persistently rise contrasting sectors where interventions have stabilised or reduced emissions this reflects the complexity of reducing emissions in a sector tied to economic growth urging advancement beyond highlevel models to tailored accurate and robust policy impact estimates on transport activity and ghg emissions addressing this path2zero equips stakeholders with a comprehensive knowledge base for developing evaluating and benchmarking netzero transport pathways incorporating crosssectoral assessments and promoting global collaboration employing a sophisticated methodology in the first cycle it harmonises data and maps describes validates and quantifies eu policy elements serving as modeling input introducing p2zdatasyncer for data alignment and p2zpolicyframemapper for policy visualisation an advanced model framework forecasts transport sector activity and emissions to 2050 integrating them across other sectors and countries for thorough ghg reduction evaluations including fairness and economic impact developing p2zforecaster for predictive modeling benchmarking follows to identify strategic gaps for achieving ghg targets per european and international targets enhancing policy alignment and scenario comparisons producing p2zevaluator for policy effectiveness evaluation and p2zbenchmarker for pathway benchmarking in the second cycle path2zero refines national and crossnational policies for stricter policy frameworks culminating in integrated benchmarked pathways that inform eu strategies generating p2zpolicyframefinder for policy framework development and p2zsectoraladviser for sector integration path2zeros collaborative approach involving national and international stakeholder cocreation ensures diverse feasible and bestpracticeinformed netzero pathway development creating p2zengager for stakeholder engagement and p2ztool for impact visualization
extended degrees of freedom in qft

quantum field theory qft is the formalism that underlies modern particle and condensed matter physics standard perturbative methods in qft have been extraordinarily successful in explaining physical phenomena involving weaklyinteracting quantum fields on the other hand many fundamental phenomena including phase transitions and nuclear interactions are described by strongly coupled qfts for which perturbative techniques are insufficient and a rigorous predictive theoretical formulation is lacking heuristic arguments indicate that a full nonperturbative formulation of qft must include extended degrees of freedom a prototypical example being the flux tubes that bind quarks inside the nucleusmy proposal describes a novel approach for studying extended objects in a wide range of qfts based on two recent conceptual breakthroughs first my research on a special class of theories the sixdimensional scfts has brought to light a rich algebraic structure that captures the properties of its stringlike excitations and second new developments in mathematics and physics point to the existence of a vast generalization of this structure which is perfectly suited to describe the extended objects of a much wider range of qftsthis program is organized along three directions analyze the families of qfts that can be studied by stringtheoretic and geometric methods and gradually uncover the algebraic structures that describe their extended degrees of freedom exploit these algebraic structures to obtain novel principles that govern the dynamics of stronglyinteracting qfts and determine the new mathematical structures that arise from the combination of the geometric and algebraic description of the extended objectsan erc starting grant will allow me to undertake this ambitious project whose pursuit will lead to a much deeper understanding of extended degrees of freedom or their role in qft and of the mathematical structures that describe them
psychology criminal interrogation and the impact of knowledge 18801940

how could knowledge make an impact in the world and on peoples lives this project investigates this question by studying the case of criminal interrogations and forensic psychology in germany france and the netherlands between 1880 and 1940 obtaining confessions often crucial to convince judges or juries of a suspects guilt was a prime concern for many interrogators in 19th and 20thcentury continental europe yet many suspects did not spontaneously confess as a result interrogators developed specific knowledge and techniques to obtain confessions sometimes inspired by psychological insights the goal of this project is therefore to assess to what extent why and how scientific innovations in psychology particularly in experimental psychology and psychoanalysis made an impact on criminal interrogations i will undertake three actions to this end the first action is to study how knowledge about interrogation circulated among and between scientists and practitioners and within and between countries the second action is to study how different actors evaluated different forms of knowledge and how epistemic hierarchies were produced the third action is to study how formal published knowledge about criminal interrogation related to actual interrogation practices in criminal investigations the project thus adds a phenomenological perspective to the history of knowledge studying how knowledge interacted with the bodies feelings spaces and objects taken together these three actions will provide a case study that shows how under what conditions and by what means knowledge could make an impact in the world through its circulation evaluation and application