Dragon09/odtu_chatbot huggingface dataset:
unlocking the potential of dredged sediments towards sustainable geopolymers for green construction

climate change poses a global challenge and the production of cement contributes significantly to greenhouse gas emissions ghg by 58 this project is therefore poised to revolutionize the industry by developing an innovative ecofriendly cement using dredged materials dms as precursors to produce greener geopolymers the latter are synthesized by mixing materials rich in aluminosilicates with an alkaline solution the ghg of geopolymer concrete is 73 and 46 less than ordinary portland cement opc concrete respectively geopolymers exhibit noticeably improved mechanical properties compared to opc concrete and have been shown to have better resistance to acid attacks high temperatures and fire however the production of large quantities of geopolymer concrete is limited due to the declining availability of fly ash worldwide dredged sediments have been identified as a potential source of silica and alumina this project sets out to establish the foundational science needed to transform dms into materials suitable for structural applications thus pioneering a sustainable path to co2 reduction this study will foster the adoption of these byproducts in sustainable infrastructure development and create a roadmap for producing dmbased geopolymers the research led by me dr amine el mahdi safhi under the mentorship of dr mahdi kioumarsi and dr shima pilehvar at stfold university college hi in norway will bolster my skills in materials and structural engineering preparing me for an expansive academic career the project is an international endeavor with the collaboration of dr ahmed soliman from concordia university canada and industrial partner netics netherlands our vision is to turn an environmental challenge into an opportunity for sustainable development by harnessing dms we will not only transform the cement industry but also positively impact society and the environment
smart gridefficient interactive buildings

evelixia brings together 36 high profile organizations from 12 eu countries envisioning to realize buildings as active utility nodes bauns rendering the eu building stock as a energy efficient b connected by facilitating a twoway communication between the grid and the occupants capitalizing on flexible technologies c smart by utilizing analytics supported by sensors and controls to cooptimize efficiency flexibility and occupant preferences and d flexible reducing shifting or modulating energy use according to occupant needs while considering utility signals evelixia structures the advancement of its solutions along five innovation pathways ip1 buildingtogrid b2g services ip2 gridtobuilding g2b services ip3 humantobuilding interfaces interactivity ip 4 systems interoperability and ip5 innovative hw as flexibility enablers which will be integrated deployed and validated at 7 largescale reallife pilots gr ro fr fi es at dk during the evelixia platform deployment and validation different actors ie dsos dnos escos aggregators from various sectors electricity heatingcooling mobility will exchange data for providing b2g and g2b services and they will participate in the development of business models showcasing the economic viability of the solutions proposed evelixia puts a large focus on social engagement empowering citizens as not only adopters of solutions but also as their cocreators applying methodologies for citizen and consumer engagement and advanced human to building interfaces key expected outcomes include 14 scalable b2gg2b services demonstrated including dsf implicit explicit shifting etc p2p energy trading portfolio management day aheadintraday tsodsodho and system planning services ghg emissions reduced by 17 increase of flexibility by up to 25 increase of selfconsumption up to 100 reduce energy consumption by 135 and increase re generation by 11
oils4cure finding an effective drug to alleviate refractory epilepsy one of the most severe symptoms in the pathology of tuberous sclerosis

oils4cure is a spanish biotech company dedicated to the research development production and commercialisation of medicinal products based on a medicinal cannabis extract it is developing a drug to manage refractory epilepsy associated with tuberous sclerosis ycj01 and another for leukodystrophies ycj02 both are paediatric rare diseases this project only deals with the development of our first and most advanced therapy directed at tuberous sclerosis ts
corpora in greater gandhra tracing the development of buddhist textuality and gilgitbamiyan manuscript networks in the first millennium of the common era

the foundation of the academic study of the development of buddhism lies in the research of surviving textual material first composed in indic languages over centuries before and into the first millennium in the last several years fantastic manuscript finds have surfaced opening new windows into the scholarly study of the development of buddhist literature i am one of the few scholars to have access to such material this project represents a multifaceted holistic approach to the study of an important and voluminous genre of manuscript witnesses from an early era of buddhist textual transmission composed in sanskrit in the gilgitbamiyan type scripts from the historic region of greater gandhra covering modern day afghanistan pakistan and parts of northern india this project centers the study of two large recently discovered caches of highly important early buddhist gilgitbamiyan type stra manuscripts and their place in the body of works from greater gandhra the first cache was excavated from the mes aynak archeological site in afghanistan and the second is a collection of newly identified manuscripts held in a private collection in thailand the philological paleographical codicological and critical research conducted in this project will examine textual and material production transmission and relationship networks in the buddhist manuscript cultures of greater gandhra and beyond in the first millennium of the common era these results will be made permanently available through the development of a digital archive allowing for the creation of an akara database of individual syllables representing unique scribal identifiers which will identify individual scribes across manuscripts and scriptorium networks digital preservation of the manuscripts their editions and translations study of their textual paleographical and codicological features and the direct comparison of the content of these texts with parallels in multiple languages
mapping genetic suppression interaction networks in dna break repair disorders

dna doublestrand breaks dsbs occur frequently during a cells lifetime and constitute the most cytotoxic dna lesion dsbs compromise genetic integrity and have the potential to trigger cell death and generate pathological mutations to counteract such threat cells possess a complex protein network termed dsb response dsbr which senses signals and repairs dsbs two predominant mechanisms repair dsbs homologous recombination hr and nonhomologous end joining nhej while loss of dsbr factors such as ku and xrcc4 ie nhej proteins or brca1 and brca2 ie hr proteins leads to early embryonic lethality and cell death inactivating somatic mutations in these very same genes are associated with certain immunological and neurological disorders premature ageing and cancer this implies the existence of a suppressive epigenetic background that enables diseased cells to tolerate the otherwise lethal loss of essential dsbr factorsthis project aims to systematically identify suppressor mutations which rescue viability upon loss of essential hr brca1 and brca2 and nhej ku80 and xrcc4 effectors to reach such goal i propose to a genetically sensitize wildtype healthy mouse embryonic stem cells and b lymphoid cells by introducing mutations using a genomewide crispr ko library in such diversely sensitized background i will then b trigger the acute degradation of ku80 xrcc4 brca1 and brca2 proteins using the auxininducible degron aid system suppressor mutations will be directly identified by sequencing sgrna retrieved from survivor cells c the resulting suppression network maps will be integrated to clinical datasets to identify the relevance of these mutations in diseasetogether this project will unravel the dsbr protein networks that permit cell survival under different dna repairdeficient conditions encountered notably in cancer paving way for personalized disease prevention and treatment strategies
galaxy mergers in the era of large surveys

as galaxies are formed to a large extent by merging of smaller galaxies knowing the merger history of the observed galaxies is crucial to understand their evolution as well as the evolution of the whole universe galaxy mergers are slow processes happening over millions of years and so the information about the merger history of any individual galaxy must be indirectly derived from its presentday state luckily a significant portion of elliptical and lenticular galaxies show a unique type of fine structure known as stellar shells which are created in mergers and can be used to date the last significant merger that the galaxy has undergone we have already developed methods to extract such information from individual galaxies now we will expand the applicability of such methods to vastly larger samples to this end we will develop a set of selfcontained tools to identify and analyze shell galaxies in images of large sky surveys so that the estimates of merger times can be automatically obtained we will apply those tools on existing data from current surveys and prepare for their application to the unprecedentedly large data set that will be produced by the large survey of space and time lsst at the vera c rubin observatory which will become operational around the time when the project concludes this will transform shell galaxies from a position of curiosity to that of utility allowing statistical applications using the merger data on the hundreds of shell galaxies that will be identified in the existing data and later on the thousands of galaxies eventually observed by the lsst project a huge qualitative leap from the handful of galaxies with known merger histories available today we will pioneer the use of this data by applying it for the benefit of lsst itself where it will help optimize the observation time in search of transients by exploring the correlation of their occurrence with the merger histories of the host galaxies
evolutionary and molecular determinants of a nutritional polyphenism

environmental fluctuations are a general challenge for organisms exacerbated in the context of global change many animals evolve phenotypically plastic responses to adjust to new conditions polyphenism is an original mechanism that produces specialized morphs to track environmental changes whether the molecular mechanisms underlying polyphenism evolve from the acquisition of novel genes or the rewiring of conserved environmentsensing pathways is an unresolved and challenging question as it requires wellcharacterized regulatory networks including the involvement of hostmicrobiota molecular interactions and relevant phylogenetic frameworks to root the evolutionary steps through which polyphenism emergedalterevo aims to understand how a nutrientsensitive polyphenism evolves and is regulated it uses aphids and their symbionts to characterize the molecular regulation of nutritional polyphenism which induces alternative morphs adapted to distinct host plants and to elucidate how this polyphenism machinery became genetically encoded it also addresses for the first time the role of symbionts on the evolution and regulation of animal polyphenisms to fulfil these objectives alterevo proposes an original approach linking the evolutionary molecular and ecological components of polyphenism and incorporating the involvement of symbionts it relies on metabolomics to identify plant compounds inducing alternative phenotypes largescale gene expression and epigenetic analyses to reveal the molecular cascade regulating morph determination functional characterization of candidate genes and phylogenomics to elucidate nutritional polyphenism evolution this project will lead major progress on the mechanisms allowing rapid phenotypic adjustments to environment fluctuations and on the role of phenotypic plasticity in evolution in a holobiont context these advances are of fundamental importance for assessing the resilience of populations to humaninduced changes
spectroscopic investigation of the electrochemical interface for sustainable electrocatalysis

the structure of the double layer at the electrodeelectrolyte interface dictates the electrocatalytic performance a better understanding of the double layer is thus necessary for the optimization of key reactions such as the electrocatalytic hydrogen production and the co2 electroconversion to valueadded products both of which are central to transitioning to carbonfree fuel alternatives however there is currently a significant lack of appropriate characterization methods to resolve this interfacial region meanwhile recent results demonstrate that the models so far employed to predict the physical behavior at the double layer are incomplete therefore for the field of electrocatalysis to reach its performance targets it is critical we develop new techniques to fill this gap in our understanding of the catalystelectrolyte interface in this work we propose to leverage the unique properties of xray photoelectron spectroscopy xps and total electron yield xray absorption spectroscopy teyxas in a dipanpull geometry to resolve the concentration and configuration of the ions and water molecules present in the double layer using single crystal electrodes that are welldefined surfaces we propose to use these spectroscopic insights to verify the nature of nonspecific ionwaterelectrode interactions suggested by previous electrochemical and computational investigations once optimized we propose to expand the application of this spectroscopic approach to electrocatalytically relevant conditions for the hydrogen evolution reaction on pt111 and for the co2 reduction reaction on au111 the asdescribed methodology will not only provide unprecedented insights into the elusive contribution of the double layer during electrocatalysis but it will also enable the standardization of a powerful characterization tool that will greatly benefit the field of surface chemistry and catalysis
infectious disease outbreaks as contributors to sociocultural transformations in the 2nd millennium bce

in recent years rapid developments in the field of ancient metagenomics enabled through advances in genomic sequencing and ancient dna retrieval have provided temporal transects of microbial diversity and have paved the way for studying humanpathogen interactions on the biological and cultural dimensions far earlier than the written historical record with these tools at hand protopest will utilise a timely opportunity for investigating the impact of infectious disease epidemics on prehistoric human societies the project will be centred on the 2nd millennium bce a period of largescale sociocultural transformations witnessed differentially across the archaeological records of europe near east and asia until now studies have focused on environmental changes economic shifts warfare and human migration to explain these phenomena crucially the 2nd millennium bears the earliest textual evidence of infectious disease epidemics ever identified yet their possible contribution to observed transformations as well as their transregional impact beyond textual descriptions remain largely unexplored protopest will produce extensive ancient metagenomic pathogen genomic and human genomic datasets generated from human and animal remains across key regions of europe the near east and central asia coanalysed alongside cultural isotopic paleodemographic and palaeopathological information these data will be used to expose the unknown landscape of middlelate bronze age epidemics across a large geographical expanse our unique multidisciplinary framework will define indicators of prehistoric community responses to infectious disease outbreaks and reveal how pathogens emerged and disseminated within and across human populations in this capacity protopest will provide a deep evolutionary and cultural framework for empirically examining the diachronic challenges that pathogens have posed on human societies to gain a more holistic view on human prehistory
developing piloting biodiversity footprinting natural capital accounting via a beehive of sectoral hubs for sustainable transition to a circular eu bioeconomy

biodiversity is the true driving force of a sustainable circular bioeconomy cbe while the cbe needs advanced technology and innovation to succeed biodiversity determines the capacity of biological systems to adapt and evolve for this reason biodiversity considerations need to be reflected in economic practices and valuation circhive will measure and integrate the value of nature into public and business decision making by 1 improving data availability accessibility and harmonisation 2 developing a standardised method for biodiversity footprinting bf and integrating it with natural capital accounting nca 3 mainstreaming the use of bf and nca in public and private decision making incl improving disclosure risk management and investment practice 4 testing and improving the developed methods and models and 5 building a wider community beehive for peer support and exploitation of results a strong emphasis is put developing scientifically robust and standardised methods that bridge bf life cycle analyses and nca bookkeeping given their multiple overlaps but also divergences that hinder operationalisation and uptake an equally strong emphasis is placed on practicetesting to understand current practices and opportunities for further mainstreaming of biodiversity and natural capital into disclosure ecolabelling and investment decisions transitioning theory to practice is put to the test via a case study network who will apply different biodiversitycentric approaches in real life this is carried out in sectoral case study hubs industry retailers investors cities for peer learning and capacity building in circhives approach cbe and biodiversity reinforce each other as a basis for resources and inspiration for sustainable business practices the integration of the value of nature into public and business decisions will benefit both the protection of ecosystems and their services and the profitability of sustainable businesses
terahertz excitons in monolithically integrated carbon nanostructures

at present mobile networks and emerging wireless technologies internet of things etc require broadband channels to exchange rapidly a huge amount of data the usage of frequencies from 01 to 10 thz has potential to increase the stateoftheart high speeds by 2 orders of magnitude however despite the latest advancements in thz technology we still lack proper materials to realize suitable thz photonic components this project aims to understand principles of designing thz devices based on carbon nanostructures integrated into a monolithic flexible and durable substrate the route to harnessing thz radiation for compact devices is seen in the usage of carbon nanostructures as building blocks for detectors emitters etc such carbon nanostructures as nanotubes and graphene nanoribbons exhibit unique electronic and optical properties that make them very promising candidates for thz components however carbon nanotube and nanoribbon monolithic onchip integration is challenging because it may results in significant change of their intrinsic properties after an embedment into a substrate we propose to investigate with first principles and theoretical methods the successful routes of such integration and calculate electronic and optical properties of the integrated structures we shall model such systems with 2d graphene superlattices in these structures quasimetallic and dielectric regions can be alternated for instance either by selective hydrogenation of graphene or by embedment of boron nitride regions the project will focus on i spinorbit interactions and the topological edge states at interfaces ii topological singularities in optical matrix element and iii excitonic effects this project has a significant impact in thz technology and wireless communications its success can lead to the realization of ultrafast wireless networks for multiuser environment the potential benefits can ensure eu leadership in the global telecom market
photonic laser integration for metrology and quantum systems

in lasiq i will develop for the first time an onchip titaniumsapphire modelocked laser capable of generating lownoise optical frequency combs in the 6501100 nm wavelength range optical frequency comb generators are light sources capable of generating a spectrum of millions of equally spaced laser lines such light sources allow to downconvert optical frequencies thz to the microwave domain ghz enabling precision laser spectroscopy and the construction of optical atomic clocks theodor hnsch and john hall were awarded the nobel prize in physics of 2005 for developing the optical frequency comb in recognition of its impact on quantum metrology timekeeping and fundamental physics since their initial development they have revolutionized several other fields such as lidar light detection and ranging molecular spectroscopy astronomic spectroscopy for exoplanet identification and ultralownoise microwave generationhowever highperformance optical frequency combs are mostly based on expensive 100 keur and bulky 900 cm3 freespace or fiberbased modelocked laser systems which strongly limits their use in realworld applications this has spurred an enormous research effort towards developing onchip optical frequency comb generators currently a large variety of integrated optical comb generators have been demonstrated ranging from soliton microcombs to semiconductor modelocked lasers however so far integrated optical comb generators cannot rival the performance of their tabletop counterparts severely limiting their application in lasiq i will address this need by demonstrating titaniumsapphire modelocked lasers on a millimetersized chip with a performance similar to that of the incumbent freespace solutionthe realization of an onchip titaniumsapphire modelocked laser will enable chipscale supercontinuum sources integrated optical coherence tomography systems onchip optical atomic clocks and dualcomb metrology