Dragon09/odtu_chatbot huggingface dataset:
hydrogel machines for seamless living system interfaces

bioelectronic interfaces are machines designed to exchange information with living matter they are opening new frontiers in medicine for example machines implanted in the body may soon enable repair of damaged tissues or replacement of functions affected by chronic disease the realisation of this vision is impeded by the available hardware todays materials devices and systems are electronic while soft living matter uses ions and molecules for communication and computation the central hypothesis of gelectro is electrically conductive hydrogels can enable bioelectronic machines that are multimodal and nearly indistinguishable from the biological host the project will thus contribute a new class of interfacing technologies that are made almost entirely of water if successful they will not only blur the boundary with the host but also tap into the control loops that organise and maintain the living systemthe hypothesis will be validated by achieving five key aims hydrogels with dual electronic and ionic conductivity will be created by combining organic conductor and biomacromolecule building blocks a tailored additive microfabrication method will be developed to combine hydrogels in devices devices that transduce electronic commands into ionic currents releasesequestration of signalling molecules and mechanical actuation and vice versa will be constructed devices will be integrated in arrays and in circuits capable of sensing and actuation in aqueous environments finally an impact case study interfacing gelectro machines with cortical organoid cultures will be developed by emulating the finely tuned morphogens present in the early stages of brain development gelectro machines will encode advanced tissue organisation and emergent electrical activity in the organoidsthe project will catalyse interest in hydrogelbased electronics as a promising technology for next generation humanmachine interfaces
the medieval book and networks of northern europe c 10001500 texts crafts fragments

medieval books were instrumental in shaping european history communicating rituals stories and ideas as they were read copied and shared to modern scholars they illuminate trade craft religious social and intellectual networks less than 10 of the european corpus survives and in scandinavia the situation is far worse however by historical accident a very high number of latin fragments c 50000 from these precious books have been preserved codicum will study and analyse the nordic book fragments as sources to medieval book culture and its networkswhile parchment fragments are found throughout europe the numbers and the randomness of their survival in the nordic countries lend them a special significance the time is now ripe for interrogating this promising material as one unique european archive by combining approaches from the humanities and the sciences how was scandinavia included in different intellectual networks and how did these networks evolve and overlap how was book production adapted to the limited resources of the north what can this crossnational archive teach us about curating textual heritage in the long termcodicum is led by pis from four different fields palaeography literature history and biocodicology this unique blending of research expertise enables an innovative synergy which will expand the perspective of european book history c 10001500 reconnect fragments to each other and digitally reassemble medieval books explore the craftsmanship associated with book production reveal the relationships between the transmitted manuscripts material and illuminate the international networks linking northern europe researching medieval book culture on an unprecedented scale codicum will seek to resituate our understanding of the book in shaping the nordic region and connecting the region to the rest of europe thereby pushing the poorly known nordic fragment archive into the fore of european bookhistorical research
chromatin reorganization in response to replication stress

background and unmet need the mammalian genome is a highly organized structure where distinctchromosomal domains occupy discrete territories and position in a nonrandom fashion genomeorganization also determines the proper functioning of various biological processes including dnareplication genome organization has been widely studied in the context of gene regulation whilerecently the role of genome organization in mediating dna damage repair at dsb sites has also cometo light however there is scarce information on how newly replicating region is organized in responseto replication stresshypothesis to be tested my hypothesis is that stalled replication forks especially at the regions proneto acquire breaks undergo compartmentalizationreorganization within the 3d nuclear space inresponse to replication stress to allow efficient fork protection and fork restart abilityobjectives this unique multidisciplinary project will yield critical information to reveal hiddenconnections of chromatin organization replication fork stability and chemoresistance with this ercproject i will determine for the first time i the mechanistic insights of chromatin organization changesmediated by chromatin remodeling activity in response to replication stress ii identify novel chromatinmobilizers associated with replication forks and iii determine the significance of chromatin reorganizationto cope with replication stress for establishing resistance towards chemotherapeutic drugsin cancer cells and patient samplesexpected outcomes my project will not only advance our fundamental knowledge on spatial temporal reorganization of chromatin architecture containing stressed replication forks but it also has ahigh potential to contribute to identifying novel targets aimed at chromatin organizers that mediatesresistance towards replication stress inducing chemotherapeutics
gogreen green strategies to conserve the past and preserve the future of cultural heritage

heritage conservation preserves the tangible remains of society but relies on toxic unsustainable materials and on energyconsuming air conditioning of collections gogreen promotes preventive and remedial conservation practices based on green principles to spearhead the green revolution within conservation specifically gogreen will 1 develop new damage functions that allow more flexible environmental control in collections thus improving energy efficiency 2 generate innovative natureinspired biobased and historical conservation treatmentinspired methods for remedial conservation including new cleaning solutions for paintings and metals all using green solvents bioinspired reagents green delivery systems and stabilization methods for metal and glass that employ innovative techniques like biopassivation to stabilize metal surfaces and nanomaterials that mimic the growth of silica to stabilize glass 3 assess our new materials and methods using cuttingedge analytical techniques and benchmark methods in collaboration with expert practitioners and museums to determine their efficacy in the cleaning of paintings and metals or the stabilisation of glass and metal objects 4 develop a digital webapp to aid conservators in the design of green preventive and remedial conservation treatments and a decision model integrating green thinking in complex conservation decision making crucially gogreen encompasses all relevant and necessary academic and socioeconomic actors spanning the full stakeholder value chain to ensure future impact our uniquely advantageous composition coupled with the embedding of bottomup education of professionals through modules and courses for conservation training programmes emerging conservators and midcareer professionals guarantees the next generation of conservators are fully prepared to embrace the greendeal
inspiring co2 circularity by introducing carbon transformation to our plates

revolutionizing food production with co2 inputs and carbonnegative microalgaee proteinssolmeyea is a biotech company producing functional food ingredients as an alternative to both animal plantbased proteins our groundbreaking ipprotected hybrid vertical microalgae fermentation hvf technology enables microalgae fermentation using co2 in lieu of carbon substrates and greeces abundant renewable energy sources this combination results in the production of carbonnegative microalgaederived proteins in various colors requiring 01 of the cropsland on 200x higher yields of the same proteinsenhancing food security geopolitics economic impactour hvf not only unlocks the full potential of microalgae but also addresses eus critical challenges reducing reliance on heavily commoditized and pricevolatile crops and glucose we support food security facilitate the production of fermented co2derived food proteins and replace imported highly processed and environmentally harmful cropderived ones we ensure the efficient production of food ingredients contributing to national and eu gdp and empower the eu to regain independence and geopolitical competitiveness solution mey protein for human consumption at scalemey is the firstever nongmo protein produced from co2 with the highest standards for human consumption through the pioneering combination of gas and microalgae fermentation we transform scope1 co2 into authorized white functional food protein compared to any fdaefsaapproved protein our microalgaederived mey demonstrate 30x higher landefficiency and 400x more sustainable in terms of water and carbon footprinteica support advancing technology to trl9 and beyondit will propel solmeyeas co2bioconversion and microalgae fermentation system to trl 9 projecting an annual revenue of 190 million by 2029 our integrated ai models ensure precision efficiency and costeffectiveness at both our demo and future flagship devel
interdisciplinary perspectives on the politics of adolescence and democracy

ippad interdisciplinary perspectives on the politics of adolescence democracy aims to address a timely pressing societal issue namely the understanding of how young adolescent citizens process political information and how this affects their engagement with politics youth engagement with politics has always been crucial for the future of democracy as the adolescents of today become the voting citizens of tomorrow their political engagement seems even more important today as we have witnessed a decline in youth satisfaction with democracy while at the same time the social and political challenges of climate change misinformation declining voter turnout polarization and radicalization raise concerns about the future of liberal democracies in europe to address these aims ippad will integrate for the first time in a systematic rigorous and mutually beneficial way two main areas of research first the extensive literature on youth political engagement from the perspective of political and social sciences and second the insights on the wideranging changes that occur in the adolescent brain obtained from the field of developmental psychology and neuroscience while prolific in their own respect these two perspectives have till now been kept separate ippad argues that a rigorous understanding of how adolescents process political information requires the integration of these two strands ippad will fill this gap by studying how the developing adolescent brain in the different sociopolitical contexts of five european countries underpins the emergence of the social and eventually political self by integrating these two perspectives and in collaboration with three major european nonacademic partners european youth parliament gallup international counterpoint global ippad will provide an indepth interdisciplinary training to a young generation of social scientists in conducting open rigorous innovative and impactful research
inclusivespaces designs tools frameworks for creating an accessible inclusive built environment for all for now for the future

inclusivespaces realizes the inclusive design monitoring and evaluation of urban space inclusivespaces introduces codesign accessibility concepts engaging people with disabilities and older people to improve inclusiveness social cohesion and climate change mitigation and adaptation it develops socially innovative solutions that foster universal design principles empower diverse targetgroups and promote climatefriendly practices five essential planning and design tools will be developed to enhance accessibility and comfort 1 a travel demand data collection and evaluation of accessibility tool 2 a comfortbased accessibility mapping tool 3 an accessibility routing tool tailored to visually impaired and mobilityimpaired individuals 4 a firstofitskind digitized tool for conducting accessibility audits in buildings and public spaces and 5 a universal design manual for the built environment including mobility hubs in addition inclusivespaces develops advanced assistive technologies 1 a mobility kiosk of shared electric wheelchairs powered by solar panels and providing shared mobility options to people with disabilities 2 a device offering enhanced accessibility to beaches and waterfronts 3 an upright tricycle providing inclusive personal mobility to people with reduced mobility 4 and 5 indoor and outdoor assistive technologies enhancing the accessibility and mobility of people with disabilities the inclusivespaces planning and design tools and the climatefriendly assistive technologies will be demonstrated assessed and evaluated in realworld demonstrations in 6 european cities and countries including athenspenteli geneva madrid larnaka hamburg and budapest project findings will be translated into actionable policies and recommendations inclusivespaces is a project and an initiative to standardize and digitize design frameworks towards a transition to an inclusive and climatefriendly built environment
forecasting and observing the opentocoastal ocean for copernicus users

the main ambition of foccus is to improve and advance the coastal dimension of the copernicus marine environment monitoring service cmems by enhancing existing capability developing innovative coastal products designing and demonstrating the integration of copernicus and member state coastal services will allow a seamless and fitforuse monitoring and forecasting of the ocean from global to regional and coastal scales coproduction of coastal services will reinforce the quality efficiency and exploitation of copernicus research and specific applications will demonstrate foccuss progress beyond the state of the art for challenges such as the protection of the coastal zone the development of a sustainable blue economy and the building of coastal zone resilience to climate change anthropogenic pressures and natural hazards at the heart of the proposed methodology is the use of new space such as sentinels and insitu coastal observations innovations in data fusion data processing and visualisation together with seamless numerical coastal prediction including interfaces for downscaling from cmems from the regional to the nearshore also connecting to the estuarine scale novel approaches will be used to ensure cmems evolves at the forefront of modern research and technology inline with the innovation and digitalisation required for the european digital ocean and water knowledge system foccus will ensure credible pathways for effective uptake and exploitation of key outcomes and research results by the cmems and the wider user community thereby fostering the acceptance and efficient application of novel information products by society this will include demonstrations of the technical readiness of the proposed evolutions and active dialogue with european and international initiatives to ensure the global community is aware of foccus and that results contribute to wider efforts
plant based emulsifiers with improved technological and physiological functionality

there is an urgent need for a new generation of healthier and more sustainable processed foods that consumers can easily fit intotheir diets the development of plantbased alternatives to animalderived products requires more research to become highqualityaffordable and sustainable pleasant faces this major foodrelated challenge by undertaking the controlled modification of a plantbasedprotein to improve its solubility and functionality as an emulsion stabilizer and encapsulating agent for fish oil rich in omega3 fatty acidshemp cannabis sativa l protein is a highly nutritional protein extracted from hemp oilseeds waste after oil extraction hencesupporting sustainability proteins are common food emulsifiers however the use of hemp protein as food emulsifier is still limited dueto its low solubility at neutral ph and compact structure i intend to apply different surfaceenzymatic treatments to hemp protein toproduce hydrolysatesparticles then i will examine the interfacial properties of hemp protein hydrolysatesparticles and theirfunctionality as emulsion stabilizers in combination with their in vitro digestibility to provide a new generation of clean emulsifiers with tailored oil encapsulation capabilitypleasant is an interdisciplinary research project where my strong background in food chemistry combines perfectly with the host groups expertise in colloidalinterfacial physics and chemical engineering to produce clean emulsifiers and oil encapsulation systems based on hemp protein that are healthy and sustainable but also physiologically bioactivethis proposal will train me to lead highquality multidisciplinary research projects on the development of clean labeled plantbasedprotein emulsifiers as well as to become a successful entrepreneurial food scientist it will also create opportunities for the hostorganization to collaborate with food scientists in academia and the food industry in the field of sustainable emulsifiers
sustainable processing of europes lowgrade sulphidic and lateritic nickelcobalt ores and tailings into batterygrade metals

the cobalt co and nickel ni demand is expected to be about 20 times higher in 2040 than in 2020 given that europe plays only a minor role in the global nico supply chains which are concentrated in the drc indonesia and china we face a serious problem in securing a reliable affordable and sustainable supply of batterygrade nico vital for europes aims to be climateneutral by 2050 in view of a domestic and foreign sourcing procurement model enicon exploits the potential of lowgrade nico resources within europe ie sulphidic nico ores and derived nicobearing pyrite and silicate tailings and limoniticsaprolitic laterite nico ores while improving and developing the nicorefining capacity that can process imported ores concentrates and intermediates enicon comprises both major improvements to existing nico metallurgical unit operations in europe as well as the development of a new hclbased route for both nico sulphide concentrates and laterites enicons hclroute dispenses with the oldschool hydroapproach of continuously precipitating and redissolving metals that requires lots of chemicals and creates problematic waste streams the hclbased route can be extended to the downstream processing of feni classii ni obtained from laterites 2 mixed nico sulphidehydroxide precipitate mspmhp from the bioleaching of corich pyrite tailings and nicocontaining silicate tailings enicon targets a forensic geometallurgy protocol making it possible to identify and mitigate the mineralogical and textural reasons for processing losses along existing and new flowsheets to make the transition to near zerowaste processing and to further reduce co2footprints enicon develops enhanced mineralmatrix valorisation processes the outputs from enicons group of european nico mining processing and refining companies will all be benchmarked in terms of positive environmental and technoeconomic impacts against current methods
the quantum twisting microscope revolutionizing quantum matter imaging

in this work we propose to build a radically new type of scanning probe microscope the quantum twisting microscope qtm that will be the first capable of performing local quantum interference measurements at a twistable interface between two quantum materials the concept already established in preliminary experiments is based on a unique tip made of an atomicallythin twodimensional material this tip allows electrons to coherently tunnel into a sample at many locations at once making it a scanning electronic interferometer with an extra twist degree of freedom our microscope becomes a momentumresolving local probe providing powerful new ways to study the energy dispersions of interacting electrons in quantum materials the same microscope working in a second modality will be thefirstofitskind platform for cryogenic assembly of interfaces between various van der waals materials with full insitu control over their twist angle finally in a third modality the qtm will make a dramatic jump by two orders of magnitude in the spatial resolution of electrostatic imaging this will open a new world of interacting electron phenomena that were so far inaccessible to direct visualization we have recently built a preliminary room temperature version of this microscope and already observed striking quantum interference and promising results on all three fronts by taking this new microscope to cryogenic temperatures we expect to make multiple discoveries on a variety of fundamental questions in interacting quantum matter
developpement of a radhard fpga with ultra deep submicron technology for space applications

the puma project sets clear and measurable main objectives to reach a trl 5 from trl 3 as follows 1define future fpga requirements for high performance space applications 2provide benchmark to assess technology requirements3define future fpga architecture to meet applications requirements4design of all fpga architecture building blocks taking into consideration performance requirements5test chip to validate reliability and radiation hardening performance of 7nm finfet
metacities excellence hub in southeastern europe

three placebased innovation ecosystems in cyprus greece and bulgaria partner together to create an excellence hub for future cities and regions in southeast europe see the metacities excellence hub is a sustainable network that offers a common platform for collaboration crossfertilization and best practices sharing across borders sectors and disciplines on knowledge production circulation and use founded upon a joint ri strategy a nexus of collaborative links across sectors joint research innovation and outreach activities as well as business modelling and sustainability plans the collaboration aims to benefit citizens stakeholders regional ecosystems and the whole see region the thematic focus on future and metaverse cities necessitates the definition of ambitious ri agendas and the uptake of advanced digital technologies digital twins dt of future citiesregions provide accurate and reliable reference representation seamlessly unifying the physical digital and human worlds and enabling stakeholders to assess the effects of any changes before investments and implementations actually occur the proposed open digital twin framework facilitates codevelopment of complementary future city domains along with their equivalent dts the applied quadruple helix model forges synergies among actors and alignment of public and private sector priorities for regional development poc studies smallscale pilots and feasibility assessments validate project outcomes green business and operation models will be developed for future and metaverse cities as well as for the metacities excellence hub investment and sustainability plans will mobilize the communities of the three innovation ecosystems to progress faster in joined efforts common investment plans for ri infrastructures and support for reallife experimentation aim to leverage national regional and european funds as well as crowd funds and private capital in a synergetic manner