Dragon09/odtu_chatbot huggingface dataset:
safety assurance framework for connected automated mobility systems

safety assurance of cooperative connected and automated mobility ccam technologies and systems is a crucial factor for their successful adoption in society yet it remains to be a significant challenge ccam must prove to be safe and reliable in every possible driving scenario it is already acknowledged that for higher levels of automation the validation of these systems by real testdriving would be infeasible by conventional methods furthermore certification initiatives worldwide struggle to define a harmonized approach to enable massive deployment of highly automated vehicles building from headstart and other initiatives sunrise safety assurance framework for connected automated mobility systems will develop and demonstrate a commonly accepted extensible safety assurance framework for the test and safety validation of a varied scope of ccam systems this will be achieved by 1 bringing the needs of heterogeneous ccam use cases 2 defining a scenariobased database framework that will broaden the headstart methodology 3 holistically addressing the ccam test scenario generation 4 preparing the required tools for comprehensive testing virtual and physical taking into account robustness scalability interoperability quality and standardization 5 integrating functional safety and cybersecurity 6involving the use cases from the initial stages acting as a guiding principle within the projectthe project will define implement and demonstrate the building blocks of this safety assurance framework harmonized and scalable safety assessment methodologies procedures and metrics taylored for use cases a federated european scenario database framework and its necessary data interfaces a commonly agreed simulation framework including tools and interfaces sunrise will work closely with ccam stakeholders as policy makers regulators consumer testing user associations and all relevant stakeholders
path towards a sustainable mediterranean sea mitigation actions to cope with marine heat waves

the ocean has stored at least 89 of the excess heat due to humaninduced greenhouse gas emissions making climate change irreversible ocean warming trends over the past 50 years have not been homogenous and some regions known as marine hotspots have experienced warming at a rate faster than 90 of the rest of the oceans superimposed on these longterm trends devastating marine heat waves mhws are defined as episodes of anomalous warming in the ocean that can last from a few days to months these extreme events have drawn scientific and public attention recently due to their dramatic consequences on marine ecosystems and their associated strong socioeconomic impacts understanding how marine ecosystems respond to climate change and in particular to mhws has been recognized as a major societal challenge and there is an evident need for a wide range of tools such as management and conservation plans to cope with the disruptive mhws in order to prevent species depletion and ensure seafood provisioning within this context seafire aims at i providing relevant information about the impact of mhws by characterising them ii improving our understanding of the marine ecosystems responses to these extreme events iii proposing mitigation actions and testing their potential effectiveness on the western mediterranean sea achieving these goals requires a multidisciplinary approach coupling physics with the ecosystems functioning and vulnerability the project combines the expertise acquired by the fellow in physical processes related to mhws with the expertise provided by the supervisor in marine ecosystem functioning and modelling specifically the project will merge cuttingedge technologies from different disciplines such as highperforming physical and biogeochemical models insitu observations fishing data ecosystem modelling and a new digital twin ocean platform
fighting childhood obesity to stay healthy all over the life

obesity rates in late teens have increased in europe from 6 in 1980 to 32 with longlasting effects on the prevalence of severe obesity diabetes and cardiovascular disease premature death and disability efficiently fighting adult obesity is difficult but prevention and treatment of obesity have proven to work better at young ages obelisk goal is to cut the roots of the pandemic of obesity in europe targeting children first obelisk is focused on elucidating predicting preventing obesity and bringing precision medicine for children with obesity obelisk medicine is also participative 4p leveraging the potential of social innovation through engagement with families scientific and medical communities daycare schools municipalities industries to achieve successobelisk objectives are 1 to bring breakthroughs in the molecular mechanisms by which causative factors interact to drive or prevent the transition from normal weight to obesity during childhood and to develop and exploit for prevention and treatment early predictive proprietary tools 2 to identify at least 3 novel childhood obesity genes with the prospect of identifying additional drug targets 3 to demonstrate the utility of targeted approaches to prevent childhood obesity 4 to bring breakthroughs in childhood obesity treatment including a reallife clinical study of a promising existing drug glp1r agonist to reverse obesity in people with mutations predisposing to early severe obesity 5 to exploit the project results and disseminate best practices to prevent and treat childhood obesity implementing education programs and translating obelisk clinical results into guidelines and proposals for policy makers to change obesity care 6 to facilitate networking and exchanges with other actions and projects in order to optimize knowledge and joint activitiesobelisk targeted approach should contribute to decrease by 35 the number of children with obesity becoming adults with obesity
theatre and gentrification in the european city

since the european middle ages the fates of theatre and the city have been intertwined mystery plays thrived amidst the urban guilds of medieval paris city comedies heralded merchant capitalism in seventeenthcentury london and ottoman shadow puppetry shaped coffeehouse culture in nineteenthcentury istanbul the emergence of the modern european city in particular was linked to the development of both statesponsored and independent theatre institutions theatre and performance practices drew on the human proximity that city living made possible and shaped the visions of cultural heterogeneity that emerged from urban cohabitation today unprecedented dynamics of migration globalization and rapid gentrification are fundamentally changing theatres importance in the urban environment theatre and performance practices are all but absent from urban studies however and theatre scholarship often views the urban question through a limited analytic lenscombining multisited ethnographic and archival research this interdisciplinary research project will focus on the key cities of london paris berlin warsaw and istanbul to analyze the complicated and often ambivalent relationship between theatre practices and urban transformation in twentyfirstcentury europe following key thematic threads like migration and memory theatre and gentrifications original case studies will illustrate the diversity of property relations and housing tenure across the european continent as well as the complex roles that theatre and performance practices play in producing urban subjectivities and structuring the cultural politics of gentrification groundbreaking in its use of theatre as its vantage point this ambitious project will change the way we think about the contradictions of culture in the twentyfirst century city from its role in securing claims to global urban stature to its position within imaginaries of authentic local resistance
prostate cancer omics oriented intervention

promote focuses on multidisciplinary education of doctoral candidates dcs in omics and artificial intelligence ai mediated intervention to improve clinical management of prostate cancer pca pca is the second most common malignancy affecting 13 million men every year worldwide tragically there is a treatment paradox as 45 of pca patients experience slowgrowing cancer and are unlikely to progress rapidly while pca is not curable at advanced stage evidently clinical management of pca is not optimal as patients which do not require treatment are overtreated while for those that immediate actions are required efficient treatment are still needed to fill the above gaps promote was formed to educate dcs in emerging omics and ai technologies and delivera novel noninvasive tools based on biomarker and ai models to guide intervention andb more efficient treatment options for advanced pca particularly metastatic driven by molecular characterisation of the disease phenotypespromote brings together 13 leading centers from different disciplines including 3 smes 4 university hospitals with clinical laboratories and 2 research institutes and 4 universities closely collaborating with solid scientific background as demonstrated by multiple publications promote research builds oni available biobanks and omics datasets within promote consortium including 3000 urinary proteomics 1100 imaging datasets paired with biopsy and pathology data 350 paired rna and proteomics urinary profiles 100 tissue proteomics and 300 phospho proteogenomic and transcriptomics profiles from public repositoriesii established software and analytical protocols on omics data integration ai feature extraction and integration systems biology pathway enrichment drug repurposing and in vitro testing andiii infrastructure to support hosting and training of dcsmoreover promote training programme has strong innovation and industrial focus
a novel integrated system of systems strengthening technical and logistical capacities to ensure better response to emergencies by synergistically addressing frs capability gaps

synergise will design develop integrate deploy test validate and demonstrate a novel integrated toolkit for collaborative response and enhanced situational awareness nitcres at the service of response agencies which ensures an upgrade to managing of complex incidents this will comprise a multitude of tools and services required for 1 boosting situational awareness and sensemaking by offering them the means to autonomously and synergistically perform indoor and outdoor exploration of incident sites towards victim identification whilst receiving at all times information about responders position and vitals as well as analyses of passive and active threats and hazards at the area of operations and 2 upgrading collaborative response and incident as well resources management by continuously sharing and updating the common operational picture across deployed teams among the chain of command and between participating agencies the nitcres armors the frs at all fronts by delivering novel affordable accepted and customized response tools and services as part of their operational assets notably the toolkit abides to privacy ethical security and legal constraints by design considers an increased degree of inclusiveness for its operators and its setup facilitates collaborative response addressing standard operating procedures the nitcres will be provided at the service of the search and rescue personnel fire brigades emergency medical police and civil protection agencies for extensive testing training and validation at component and toolkit levels in the framework of a rich integration testing and validation activities programme of round tables rts collaborative lab tests clts technical integration workshop tiws component field tests cfts and system field tests sfts towards empowering collaborative response and handling of complex incidents to its fullest
smart manufacturing for autologous cell therapies enabled by innovative biomonitoring technologies and advanced process control

autologous immunotherapies have revolutionised cancer treatment providing impressive survival benefits in patients with blood cancers the next generation of personalised immunotherapies using tumourinfiltrating lymphocytes til aims to overcome efficacy limitations of cart therapies in the treatment of solid tumours lack of effective fast adaptive controllable and scalable manufacturing process remains one of the critical bottlenecks for clinical adoption of such complex personalised cell therapies in the smarter project achilles therapeutics uk limited a clinicalstage company developing autologous cell therapies partners with the centre of excellence for cell and gene therapy catapult and academic experts in process biomarker discovery instituto de investigacion sanitaria la fe and bioprocess sensor development leibniz universitat hannover the consortium aims to develop a firstinclass smart bioprocessing manufacturing platform for personalised autologous cell therapies implementing for the first time inline process analytical technologies and smart process control systems the project exploits breakthrough discoveries of novel t cell expansion process biomarkers and development of new fluorescence spectroscopy sensors for realtime monitoring of critical process parameters toa enable adaptive process control of the precision til biomanufacturing process after the project the prototype rd platform will be ready for followup development of the commercial scale bioreactor in gmp environment the smarter platform will critically improve production efficiency reduce overall costsofgoods shorten manufacturing cycle times shorter veintovein time decrease batch failures and lead to more consistent and predictable cell therapy product quality finally the innovations will enable clinical implementation of a potential breakthrough personalised adoptive cell therapy for hardesttotreat solid tumours such as lung cancer and melanoma
total optical coherence characterization for automated tumor analysis

drug resistance whether intrinsic or acquired during the course of treatment is the primary cause of cancer treatment failure resistance is a complex and highly personalized problem depending on tumorspecific genetic and other factors but certain cancers are particularly difficult to treat in particular the most common and deadliest type of cancer originating in the brain glioblastoma gbm is aggressive and highly resistant to treatment due to the complex nature of gbm advanced methods for screening personalized treatment strategies are critically needed to improve patient outcomes cell spheroids are 3d tissue cultures that have proven to be a more accurate model of tumor tissue for therapeutic testing however they are sensitive to their growth and preparation conditions variability in spheroid properties may affect the results of therapeutic testing so a method of identifying spheroids with properties that match the original tissue is needed in order to combat gbm and other drug resistant cancers we propose the development of two novel optical imaging systems these systems will perform nondestructive characterization of tumor tissue and live monitoring of in vitro drug testing on tumor spheroids both imaging systems use a unique design to scan the tissue samples at different angles to quantify a wide range of optical properties within the tissue with 3d micron scale resolution this approach integrates several different optical coherence tomographybased methods and addresses their weaknesses to create a unique platform for comprehensive measurements of optical properties this platform will be used to scan the original tumor tissue and the resulting tumor spheroids to identify which spheroids will most reliably mimic the original tumor tissue for testing different therapeutic interventions this approach has the potential to advance the field of personalized medicine and enable more rapid and reliable development of cancer therapies
ruthenium peptide bioconjugates for photoactivated chemotherapy

one of the most severe limitations of current anticancer chemotherapy are the serious side effects caused by toxic drugs affecting not only tumors but also healthy organs local activation of drugs by light irradiation of the tumor is a promising approach to control where the toxicity is delivered metal complexes are well suited for photoactivated chemotherapy but their activation wavelength is often too low to afford high tissue penetration of light also their ability to enter cancer cells is often controlled by lipophilicity tuning which is unselective finally their phototoxicity often relies on oxygendependent mechanisms while many tumor tissues show low dioxygen concentrations the aim of this proposal is to develop new metallodrugs that are activated by red or nearinfrared light enter cells by controlled mechanisms and deliver strong phototoxicity to cancer cells also under low oxygen conditions the design is based on connecting multiple ruii metal complexes to a biologically active antitumoral peptide the ruthenium complexes will have a tuned coordination environment to allow rednearir light activation meanwhile the peptides will rely on methionine residues to coordinate ruthenium and allow controlled cellular uptake of the prodrug into cancer cells both components will cage each other in the dark thus affording low toxicity while lightinduced cleavage of the rutheniumthioether bonds will release two bioactive components which will kill cancer cells the novelty of this proposal is to combine metalbased photoactivated chemotherapy with therapeutic peptides to enhance phototoxicity by creating synergies between both photoproducts by combining light activation resulting in timely and spatiallyresolved toxicity release and bioactive peptides which will improve uptake in cancer cells this project will deliver new fundamental knowledge on the interaction between peptides and metals and between metallopeptides and cells
transcription factormediated induction of cardiomoycyte proliferation

heart failure is a major global public health problem affecting over 23 million patients worldwide there are no effective therapies for heart failure that regenerate the damaged heart muscle following injury such as a myocardial infarction the adult mammalian heart has an extremely limited intrinsic capacity for regeneration due to the fact that mature cardiomyocytes are unable to proliferate to date attempts to reinduce proliferation in mature cardiomyocytes of the adult heart have not yet been translated into the human clinical context much remains to be learned about molecular mechanisms controlling cardiomyocyte proliferation in humans if the therapeutic potential for cardiac regeneration is to be realised with my extensive training and expertise in molecular and stem cell biology i plan to generate and exploit an innovative live cell cycle reporterbased screening platform to identify transcription factors tfs that can be induce cardiomyocyte proliferation the three major objectives of this research proposal are 1 develop a highcontent screening system to monitor cardiomyocyte proliferation in 3d human cardiac organoids which will then be used to2 identify combinations of tfs that drive the human cardiomyocyte cell cycle3 assess the therapeutic potential of tf activation for cardiac regeneration in a preclinical human cardiac model system i will receive extensive training in the ex vivo cardiac tissue culture system objective 3 which will complement my proven expertise in the generation of genetically modified 3d cardiac organoids and knowledge on cell cycle regulation objective 1 2 altogether the tool development results and training obtained during this project will put me in the forefront of the cardiac regenerative field
a political economy of ova banking in spain and ukraine

with the growing international demand for donor ova spain and ukraine have developed into leading suppliers of donor ova for the burgeoning ova donation industry in europe the banking of ova and their transnational shipping is the subject of fierce political and ethical debate among policymakers and medical professionals in europe while selling human ova is illegal countries interpret the relevant legislation differently and find regulatory loopholes which results in an emergence of market relations around the exchange of ova this growing transnational ova market makes europe a key nodal point for understanding the process of valuation of human reproductive materials however a comprehensive research project on the economic value of ova under different regulatory regimes is currently lacking cryovalue addresses the fields knowledge gap by asking how the model of ova banking in spain and ukraine influences the valuation of ova produced for market exchange while most of the literature on arts focuses on the cultural understanding of reproductive technologies their restrictions and experiences resulting from them cryovalue develops a political economic approach by conducting comparative analysis of the ova banking in spain and ukraine cryovalue explores how the value of ova is affected by the countries political and economic position in europe and how it shapes the wellbeing of ova donors moreover cryovalue investigates how the spanish and ukrainian ova banking industries are impacted by the war and how they generate value within rapidly shifting regulatory regimes markets and state borders this project is based on multisited ethnographic fieldwork employing participatory observations in the ova banks and interviews with medical professionals coordinators couriers and ova providers in spain and ukraine
planning regionalscale multimodal operations for innovative air mobility services

priams vision is that within the next decade regionalscale iam services will be part of the european maas ecosystem helping address regional connectivity challenges decisions on iam will be supported by digital twins powered by mobility data spaces and ai tools iam services will create sustainable value for aviation while improving passenger experience boosting capacity enhancing efficiency and minimising environmental impacts the general objective of priam is to develop a data analytics and modelling toolset that supports a passengercentric integration of iam into multimodal regional transport networks across europe the priam solution will help understand passenger needs for regional travel anticipate iam adoption and use patterns plan resilient iam infrastructure networks that are seamlessly connected with other transport modes and optimise iam service performance taking advantage of multimodal data sharing and passenger information systems the specific objectives of priam are i define an impact assessment framework for regional iam services that evaluates how different iam vehicular concepts and business models address regional connectivity challenges and passenger needs ii develop and validate a concept outline for priam consisting in a data analytics and modelling sesar solution for planning the integration of iam infrastructure and services into regional multimodal transport networks iii evaluate the capabilities of priam through a set of case studies in european regions that show how the priam solution can help iam regionalscale services improve passenger experience capacity environmental sustainability and operational and cost efficiency and iv derive a set of recommendations for the implementation of regional iam services based on a costbenefit analysis that anticipates the impacts of a largescale deployment of iam services across europe