Dragon09/odtu_chatbot huggingface dataset:
reliable and scalable procedures for the isolation and loading of extracellular vesicles

exosomebased therapies are among the hottest topics in biomedical research driven by the unique properties of exosomes regarding stability low immunogenicity prolonged circulation and especially selective targeting in 2022 over 50 clinical trials using exosomes for therapy were under way in diseases ranging from cancer to diabetes to central nervous system disorders however both current research on exosomes and their future translation into clinical therapies are hindered by two significant problems the first is the isolation of exosomes and of extracellular vesicles in general a highly challenging task due to i the high complexity of the body fluids that contain them and ii the delicate nature of exosomes themselves soft entities of 50150 nm whose membrane is responsible for key properties and must be preserved ultracentrifugation the standard isolation method has clear limitations low yields impurity of the products and damage to exosomal membranes due to long processing times at high g while numerous alternatives have been commercialized size affinity and precipitationbased methods these issues remain unsolved the second problem relates to the loading of therapeutic agents nanoparticles drugs sirna mirna into exosomes without damaging their membranes another challenge without a solution today laborious leverages the experience gained in adg cadence to propose innovative solutions a novel tangential filtration procedure will segregate exosomes by size removing impurities and minimizing pressureinduced membrane damage also a pioneering continuous electroporation system will provide unprecedented control allowing the load of therapeutic cargo with minimal membrane disruption results will be closely monitored for patenting and commercialization in collaboration with an industrial observer
alwayson intelligent sensing with the spiking neural processor

over the last 5 years the number of devices equipped with sensors has grown exponentially reaching 4 billion per year in batterypowered devices such as phones smartwatches wireless earphones video doorbells energyefficient processing of the complex continuous data coming out of multiple sensors is a critical problem innatera is a trailblazing semiconductor spinoff of the tu delft is bringing to the market neural processors our spiking neural processor snp is inspired by the way neurons function in our brain using a neural network with an inherent notion of time at the sensor edge snp can deliver alwayson pattern recognition functionalities in power latencysensitive applications via an innovative programmable architecture it enables applicationspecific customers to implement immediately readytouse highperformance pattern recognition snp delivers marketleading differentiation with faster timetomarket reduced development effort
proof of concept prototype for matching applications on belfort hardware

the world has become one global village strongly connected by the internet users applications and companies produce huge amounts of data this data is mostly very private health financial commercial data etc requiring organizations to encrypt the data when storing or transmitting it in europe fortunately our gdpr regulations are very strict about this on the other hand many legitimate applications want to inspect or match the data with some database examples are matching encrypted names with a red list providing privacy in financial transactions or matching encrypted dna snippets in a database a solution to these conflicting requirements is offered by a new field in cryptography computing on encrypted data coed and more specifically fully homomorphic encryption fhe with fhe data sits encrypted in the cloud the data holder ie the remote server has no knowledge and is unable to decrypt the data the magic of fhe is that operations can still be performed on the data even though it remains encrypted unfortunately it is currently too slow and too cumbersome to be used in practice within our erc grant belfort which focuses on hardware acceleration for computing on encrypted data a novel hardware processor demonstrates orders of magnitude speedup for essential operations in fhe this poc aims to move from our academic proof of concept into a fullstack project integrated into opensource and commercial fhe libraries we then plan to run a demo on an application of database lookup operations keyword matching as they appear in many fhe applications the ultimate goal of this project is to make operations on encrypted data efficient enough to perform them on the fly in a cloud setting when a user formulates privacypreserving encrypted queries to a server it should be imperceptible that the operations are occurring in the encrypted domain being able to answer a query on the fly without delay will make this goal happen
easy listening optimizing the consequences of effortful listening in occupational settings

disturbing noise is the most frequent workplace complaint noise and high levels of listening difficulty and effort lead to stress and fatigue which are further linked with mental health problems productivity loss increased sick leave and early retirement annual burden 476580 billion euros in europe in demanding or noisy work situations or for people with impaired hearing high effort may be needed to maintain performance this can have adverse consequences such as stress and fatigue however applying effort to listening leads to positive consequences as well good work performance pleasure safety societal participation in easily our stance is to optimize the ratio between the costs and benefits of effortful listening listening value in order to understand and reduce its socioeconomic burdenas we lack tools to measure listening value easyli will train 6 research fellows to develop and apply an innovative interdisciplinary toolbox of ambulatory and laboratory measures of listening effort and listening value they will gain intersectoral knowledge apply realtime acoustic scene analysis virtual acoustics and physiological and subjective measures in laboratory and reallife occupational conditions with this approach easyli aims to detect fatigue early and examine how individualized interventions eg machine learningbased speech enhancement algorithms hearing aids optimize listening value easyli consists of 5 academic partners and 4 nonacademic partners representing hearingaid and communication systems industries audiology and occupational sectors with challenging acoustic environments the easyli doctorate programme will train a new generation of leading entrepreneurial scientists and will stimulate employment by developing tools that allow early identification and prevention of listening related fatigue and stress
usercentred optimal design of electric vehicle with smart ecorners

inwheel motors iwms have become a mature technology that is wellsuited for new usercentric electric vehicles evs iwms can be integrated in multifunctional and controllable modules consisting of the electric powertrain friction brake and suspensionsteering actuation by combining several vehicle functionalities in a compact solution the modules offer substantial opportunities to enhance the design and the operation of evs this is the starting point of the smartcorners project using machine learning and ai an adaptive multilayer control strategy will be implemented with historical and current data from the vehicle its environment and users including relevant ev fleets this approach will pave the way toward softwaredefined vehicles enabling rightsizing holistic optimisation innovative fault mitigation and actuator allocation strategies as well as more efficient adaptive predictive and personalised system operation smartcorners will bring a so far unexplored authority level over i vehicle design through skateboardlike chassis configurations ii energy management aspects covering preconditioning and predictive thermal management during ev operation iii comfort and functional aspects in terms of usercentric cabin thermal management and preemptive vehicle body control and iv dismantling process and recycling of the vehicle the development and industrialization of the project outcomes will be accelerated by comprehensive and integrated simulation design and validation methodologies to decrease development time and cost and support the uptake of aibased solutions in conclusion smartcorners will provide a significant competitive advantage of the european industry and contribute to achieve key strategic orientations c and a of the eu strategic plan
joycenstein james joyce gertrude stein and the modernist coterie

the aim of this fellowship is for the researcher dr dr georgina nugentfolan to develop the professional prowess highimpact dissemination advanced training and practical experience commensurate with the role of a leading independent researcher in the eu the researcher will be based for 24 months at the university of vienna uv supervised by professor dr sylvia mieszkowski research training will be implemented through an interdisciplinary project that conducts the first extended comparative study of the modernist writers james joyce and gertrude stein the project will compare their styles across all their major works exploring how their contrasting aesthetics has shaped contemporary understandings of modernism the project will also investigate the fabled antipathy they harboured towards each other and how this has influenced subsequent critical engagements with their works the key output will be the first monograph to be written on joyce and stein but the project will also communicate knowledge to a public audience through appropriate outreach activities the researcher will access expertise mentoring advanced training and gain access to the vienna centre for irish studies cis the most prestigious centre for irish studies on the european continent due to its unique position as the host of the cis together with the interdisciplinary support and mentorship available from the supervisor the uv is the best institution in europe for hosting this project the researcher will be given the opportunity to disseminate and embed her new research through conferences and a symposium the resources of the host institution will facilitate development of an interdisciplinary and international academic network together with careermentoring the fellowship will establish the researcher firmly at the centre of modernist studies positioning her for a successful erc starter grant application and advancing her career goal of obtaining tenure at an eu university
protecting and stimulating plurilingual identities in learners in europe via inclusive policies and classroom practices

the linguistic capital of europe forms an important part of the euidentity yet there are a number of challenges that threaten this capital in this project the focus will be on problems that affect and can be effected by education only the rise of english as lingua franca caused other languages to be pushed to the sidelines leading to situations where pupils are less or even not motivated to learn other languages besides english even if it concerns an official national language of their country although multilingual programs like content and language integrated learning can affect these attitudes the large majority of these kind of programs also use english as target language which does not increase the proficiency in other foreign languages a second threat to the linguistic capital has to do with the protection of heritage languages where we see that the linguistic capital of eucitizens more and more includes noneu languages in schools homelanguages are often rejected and usage of them is sometimes even punished leading pupils who are ashamed of their linguistic capital and have a lower sense of belonging the increasing popularity of new technologies like chatgpt and machine translation also threatens to acquisition of languages as pupils do not feel the need to learn languages any more at the same time these new technologies offer many opportunities for teachers in their classrooms all these treats can be managed via good evidencebased policies at different governance levels and by ensuring teachers receive sufficient training and inspiration on how to accept and stimulate the linguistic capital of pupils this will be done in this project via intense collaboration with stakeholders at different levels to ensure that sustainable guidelines policies and practices can be implemented
from soils to apex species chemical pathways effects and impacts on terrestrial biodiversity and ecosystem services and applications for better chemicals management

the overall aim of terrachem is to develop demonstrate and apply a novel systems approach integrating monitoring environmental modelling data management analytical tools and user guidance to better understand exposure of terrestrial biota across trophic levels from soil and soil water to plants to primary and secondary consumers to apex species in europe to the universe of environmentallyrelevant anthropogenic chemicals and their damage on terrestrial biodiversity and ecosystem services with a view to enabling more efficient environmental risk assessment of chemicals in the terrestrial compartment and more effective prevention and mitigation accelerating achievement of the eus zero pollution ambition terrachems objectives are 1 to understand routes of exposure to chemicals in wildlife including routes and extent of trophic transfer for selected food chains from soil and soil water to plants primary and secondary consumers and apex species in representative terrestrial ecosystems 2 to model sourcetoreceptor pathways of selected chemical contaminants for terrestrial ecosystems and link organism and species effects to damage on genetic and functional diversity and on relevant ecosystem services 3 to develop tools and guidance for regulatory and practice uptake of terrachem research and innovation output to optimise current environmental risk assessment of chemicals and improve risk management measures and thereby reduce chemical damage to terrestrial biodiversity and 4 to refine the terrachem conceptual framework ensure integration of monitoring under objective 1 modelling objective 2 and prevention and mitigation objective 3 ensure coherence with related project platform partnership and policyregulatory initiatives and pertinence for key endusers and develop a terrachem data management system and terrachem dashboard as a onestop shop for data on contaminants in terrestrial biodiversity in europe
formation of degradable photoantimicrobial materials via light induced 3d printing

it has been an ongoing requirement for humankind to access useful objects or to provide the missing part of damaged products 3d printing 3dp has become popular by completing these deficiencies in a very short time and low cost its many derivatives are available however it is a necessity to choose suitable modules and inks that fulfill the needs of in todays world energy consumption of the world is increasing rapidly and this concept should be carefully considered in every step to be taken from social life to industrial life thus lightinduced 3d printing l3dp stands out with its features such as using clean energy source high resolution and accuracy nonetheless substantial effort is necessary to identify and put into action suitable photochemical interactions for this objective significantly the selection of these interactions must be carried out carefully since the resulting materials should meet other contemporary demands such as recyclability dibenzazapine dba and triazolinedione tda are important molecules capable of giving lightinduced reactions their reversible reactions with light and buffer solutions offer them the advantage to form degradable products and they can be promising candidates for l3dp on the other hand following the impact of covid19 the medical industry has reached a pivotal moment where the significance of antimicrobial materials has been better understood however the developed materials cannot keep up with the resistance rate of microbes and different combat strategies are necessity to cope with them antimicrobial photodynamic therapy apdt is method which is utilized the interaction between photosensitizer ps and light and it can be strong alternative for this purpose in this context zinc phthalocyanine as photosensitizier will be incorporated into 3d materials to obtain degradable photoantimicrobial properties thanks to dba and tad photochemical reactions
regulation of the dna repair response by della proteins

dna damage represents a threat for organisms because it can generate harmful mutations in the genetic material that not only affect the individual but can also be transmitted to the next generation plants are sessile organisms that are exposed to mutagenic agents and it is a reported cause of productivity loss in crops when dna damage occurs organisms trigger a signaling pathway called dna damage response ddr the aim of ddr is the transcriptional regulation of genes related to cell cycle endoreduplication and cell death to limit the harm preliminary data obtained at the laboratory indicate that plants with low and high della activity are less and more tolerant to dna damage under stress conditions respectively dellas are important growth repressors involved in several regulatory pathways these proteins act as regulatory hubs linking environmental signals with cellular functions and coordinating growth and stress responses in this project we propose to elucidate the mechanism by which della proteins act to enhance ddr using drought stress in arabidopsis thaliana as a study model this will generate new knowledge about the function of dellas in plants allowing the possibility of design novel tools to improve crops of agronomic interest in the future
lowemission power supply for emergency shelters and bases of operations

during largescale natural or manmade disasters eg flooding wildfires earthquakes with damaged infrastructure access to reliable scalable and portable energy supply is crucial for emergency response organizations ero it enables the operability of bases of operations boo during response activities and of emergency shelters es for the affected communitiesso far no other technology surpasses diesel generators in meeting energy supply requirements for boo and es despite their negative effects including noise heat and greenhouse gas ghg emissions moreover the dependence on local fuel further impacts the already disasterstricken areas exacerbating resource challenges faced by local communitiesto address these challenges leveraging the advances in renewable energy re technology is the key to achieving true selfsufficiency and providing a lowemission power supply for boo and es while mitigating the aforementioned disadvantages powerbase follows a holistic capabilitydriven approach to address this gap and create a community of european eros and innovative renewable energy solution supplierseros will describe and validate their unmet lowemission power supply needs in functional and operational terms at the same time a comprehensive state of the art sota analysis will map marketready and emerging re technologies in the following open market consultation requirements and sota will be communicated to solution providers through its procurement strategy and enduser driven needs powerbase establishes the ground for the future adoption of existing and emerging re technologies that can enable the transition towards a lowemission reliable selfsufficient mobile power supply for es and boo contributing to eu green deal 2050 target of 55 ghg emission reduction this transition will also significantly improve the accommodation conditions of emergency responders sheltered people in es and acceptance within local communities
using mineral carriers for pheromones to apply the ecologically friendly mating disruption method for protecting crops against pests on a large scale

over many years lithos developed and patented its micro dispenser technology a method where specific pheromones brand name pherolit are applied on a natural mineral as carrier lithos extracts and processes the highquality mineral clinoptilolitezeolite from its own source to optimize the unique properties in binding and releasing pheromones for the application on the field the pheromone of a particular pest is applied on finemilled treated zeolite and dispersed in water the sprayable formulation can be used with any conventional spraying device using fully natural ingredients the innovative technology provides efficient and safe plant protectionthis results in a unique set of advantages for customers sprayable easy to use affordable safe for users slow release long term effect target specific does not affect other organisms derived from nature no harmful residues pests cannot develop resistancies suitable for conventional organic farming
hazardous pesticide bans and earlylife health outcomes

farm to fork strategy aims to reduce hazardous pesticide use by fifty percent by 2030 to help achieve a climate neutral europe but it is still an open question whether potential benefits of the proposed strategy can outweigh its costs therefore it is crucial to examine if eliminating harmful pesticides can provide significant health improvements and to weigh these health benefits against the potential economic costs of adopting safer but less effective plant protection practices the projects main objective is to examine the impact of hazardous pesticide bans on earlylife health and economic outcomes in türkiyepestban will expand the stateoftheart knowledge on economics of pesticides in several aspects first it will contribute to previous studies on pesticides and health by comparing earlylife health outcomes within agricultural areas as they switch from hazardous pesticides to safer alternatives second the project will contribute to existing literature on economics of pesticide bans by monetizing the health gains from harmful pesticide bans and comparing these benefits to economic impact of bans on agricultural production areas the project has the potential to encourage adoption of stricter regulations on hazardous pesticides by highlighting the health benefits of pesticide bansspecific aims of the project include 1 data collection on hazardous pesticide use and established bans in türkiye agricultural production and crop prices acquisition of individual health data from national birth registry and national health surveys 2 empirical analyses to investigate economic and health effects of pesticide cancellations established between 2005 and 2015 3 implementation of models from soil and water sciences to evaluate the pollution potential of groundwater sources and to provide insights on whether hazardous pesticides can persist in the environment and continue to threaten the public health in surrounding regions long after the imposed bans