Dragon09/odtu_chatbot huggingface dataset:
a certification approach for dynamic agile and reusable assessment for composite systems of ict products services and processes

cybersecurity certification as introduced by the eu cybersecurity act eucsa will play a crucial role in increasing the trust to and security of ict products ict services and ict processes cybersecurity certification is a complex process posing a variety of challenges to the different interested parties this proposal introduces the custodes a system comprised of a variety of components with the aim to provide trustworthy costeffective agile and portable conformity assessment capabilities to a variety of interested parties covering multiple assurance levels of composite ict products or ict servicesthe custodes system will discover and translate certification information of the building blocks of the composite ict products or services under evaluation will provide certification information to the interested parties and will share information on newly identified vulnerabilities related to the specific blocks or composite products as needed increasing transparency reusability and trust it will also utilize a restricted trusted execution rte environment to ensure the chain of custody of the product under assessmentcustodes will be validated in three pilots a one of two class i composite products with digital elements b one of an ict product with an embedded ai component and c a final one of the asaservice functionality through eit digital extensive digital ecosystem the custodes project is built on a collaboration of 17 organisations from 11 eu member states and third countries the consortium which includes 3 conformity assessment organizations is composed by 10 smes 3 large industry partners 2 research organizations and 2 public organizationsassociations the consortium is led by rise which has extensive experience in national and european research projects and numerous collaborations with industrial partners
moleculebased magnetoelectromechanocalorics

molcal will contribute to establishing a critical mass of researchers in promising exploratory topics on caloric materials and energy conversion technologies for solidstate cooling and heating applications at nearambient and verylow temperatures temperature control systems are responsible for approximately half of the eu energy consumption expenditure this figure alone amply justifies the need to dedicate great efforts to the search for alternative refrigeration and heat pump methods research on caloric materials has never been as active as it is now due to the prospect of newgeneration refrigerators and heat pumps that are energy efficient and environmentally friendly on the one hand and the policies on lowenergy consumption and global warming refrigerants on the other molcal presents an approach never tried before in similar collaborative research training programmes we will consider caloric materials that fall under the umbrella of moleculebased materials and can respond to different sources of the driving stimulus be it magnetic electric andor mechanical since there is no clearcut consensus on which type of caloric material holds the most promise this multifront approach will be an advantage because it will permit transfer of methods already developed from the magnetocaloric subfield into the others which are increasingly in the spotlight because of their enormous potentiality furthermore molcal will develop devices based on lowcost barocaloric materials and due to the molecular characteristics will progress towards challenging applications by exploring the limits of the smallest size of magnetic refrigerators academic and nonacademic leaders from top research institutions in europe and outside will expose the doctoral researchers to integrative multidisciplinary and multisectoral training in chemistry materials science physics device development and relevant transversal skills
harnessing rara signalling for curative aml therapies

in acute promyelocytic leukaemia apl retinoic acid ra and arsenic trioxide ato bind the pmlrara fusion to promote its degradation derepressing unknown master regulatory genes and activating a pmlp53 checkpoint which is required for apl cure apl initiation deregulates retinoic acid receptor a rara signalling these deregulations are likely shared with a sizable subset of nonapl acute myeloid leukaemia aml the 30 that overexpress normal rara and exhibit some rasensitivity ex vivo clinical trials have demonstrated some benefit of ra addition to conventional therapies in nonapl aml patients but have not resulted in the incorporation of ra into standard therapies thus modulation of rara signalling is an unrealized target for treatment of nonapl amls of importance rara serves a dual function in apl by promoting leukemogenesis in the unliganded state but also by enforcing raresponse we made the striking observation that overexpression of rara suffices to confer cell selfrenewal ex vivo and rasensitivity in several aml models we propose to i define the actual effects differentiation selfrenewal and cellular mechanisms senescence apoptosis growth arrest underlying ra action on a variety of primary myeloid cells overexpressing rara ii delineate the mechanisms underlying rara overexpression in some human amls iii identify the rara downstream targets that drive selfrenewal iv discover novel racontaining drug combinations exhibiting synergies for aml clearance in rasensitive transformed myeloid cells this proposal is based on our previous modelling of apl therapy and recent disruptive observations this renewed exploration of raradriven progenitor selfrenewal will allow us to define novel curative racontaining strategies and biomarkers for many aml patients unfit for chemotherapy who are currently not eligible for cure
enhancing competitiveness resilience and sustainability of remote farming forestry and rural areas through holistic assessment of smart xg lastmile and edge solutions gains

new trends such as teleworking and ecommerce as well as the need for a further increase of digital tools in all sectors ie health education transportation farming etc demanded by the covid19 pandemic are pointing out once again digital territorial inequalities supplychain disruptions and deficiencies in economic opportunities that hamper resilience and prosperity of rural communities accessibility and connectivity are key issues to mitigate this erosion of socioterritorial cohesion however identifying a common solution for equipping rural communities with increased access to services opportunities and adequate innovation ecosystems ensuring that no one left behind is a challenging task mainly due to the diversity of challenges and needs of different locations in this respect xgain fosters a sustainable balanced and inclusive development of rural coastal and urban areas by facilitating access to relevant stakeholders such as municipalities policymakers farmers foresters and their associations to a comprehensive inventory of smart xg lastmile connectivity and edge computing solutions and of related assessment methods the xgain overall project objective is to deliver a knowledge facilitation tool facilitating business model development supporting decisionmaking in the selection of an ecosystem of technologies consisting of connectivity options and edge processing solutions by following a multiactor and practitioneroriented approach and by coherently assessing their socioeconomic and technoenvironmental effects aiming at increasing systemic resilience and energy efficiency contributing to climate mitigation and reducing the digital divides between different types of citizens farms sectors and regions
nanoscale analysis of symmetry and molecular membrane topography

the compositional and structural asymmetry of cell membranes remains one of the greatest knowledge gaps in cell biology cells invest significant amount of energy to establish and maintain interleaflet asymmetry however the physiological roles of bilayer lipids during dynamic cellular processes in eukaryote membranes remain poorly understood mostly due to the limits of previously available methodologies and the complexity of lipid membranes current knowledge originates from indirect and perturbing techniques ie enzymatic digestion and mass spectrometry which significantly limits the applicability to certain cell types with no internal membranes moreover these bulk methods do not provide spatial information on lipid asymmetry which prevents detailed observation of subcellular changes during dynamics processes such as hostpathogen interactionsin this project i will develop a method to directly visualize and quantify membrane asymmetry which will be applicable to study any cell type as well as intracellular membranes recent advances in superresolution microscopy including my latest publications paved the way for direct observation and quantification of lipid asymmetry i will combine stateoftheart isotropic expansion methods with superresolution microscopy to visualize membrane lipids in individual leaflets of bilayers to obtain further insights on the physiological role of membrane asymmetry i will investigate changes in lipid asymmetry induced by infection with viral particles the novel methods i will develop will significantly contribute to a better understanding of lipid asymmetry in biological membranes and its impact in cellular physiology and diseases mechanisms
high throughput realtime monitoring and prediction of fruit cracking by utilising and upscaling sensing and digital data technologies

fruit cracking is a peel disorder limiting fruit quality and yield the phenomenon occurs mainly in the preharvest stage and affects many types of fruit external conditions like climatic and environmental conditions and orchard management play important roles in increasing the incidence of the phenomenon this cracksense will condict reasers in il fr de lt el cracksense aims to address the problem of fruit cracking in citrus pomegranate table grapes and sweet cherries by developing and upscaling sensing technologies that will provide realtime sensor data through piloting activities the sensor data collected will be upscaled into euwide data sets which will encompass earth observation data provided by copernicus eg sentinel and other data sets reflecting on environmental conditions this data will be used to monitor agricultural production of the studied crops and enable farmers and growers efficient management of their resources and sustainability of their actions by improving the agricultural production of these crops cracksense will as well help in creating a model for other agricultural crops furthermore cracksense will address the critical need for efficient and realtime monitoring of agrienvironmental conditions because these conditions have a great influence on agricultural production by deploying sensing technologies cracksense will enable high throughput assessment of cracking incidence risk at fruit tree field and regional scale to mitigate the negative effects of the cracking phenomenon by reducing 12 of the yield losses due to cracking the use of the integrated cracksense solution will result in 50 higher financial gain for farmers and growers integrated cracksense solution will enable farmers and growers to optimise their cost efficiency and generate pathways for more income fostering complementarities between partners will enable us to fulfil our goals to bring stateoftheart cracksense solution to end users
investigation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy cadasil using induced pluripotent stem cell modelling and targeted therapeutic research

cadasil a rare disease of the small blood vessels is caused by mutations in notch3 and can cause cognitive decline leading to dementia vascular disease is the second most common cause of dementia with the burden set to increase with population aging insights into cadasil will prove instrumental in understanding and treating the vascular contributions to cognitive impairment and dementia vcid there are no therapies for cadasil and a lack of translational human models for identification of dysfunctional pathwaystargets and screening of existing and novel therapeuticsrecent proteomic insights generated at the elahi lab show that leukocyte extravasation vascular fibrosis and inflammatory processes are upregulated in cadasil this project will investigate the antiinflammatory and antifibrotic effects of novel proresolving synthetic lipoxin mimetics slxms the objectives are to investigate 1 which cell types and pathways in the vasculature are affected in cadasil through the use of patientderived ipsc unicellular and multicellular vascular models 2 which immune cell types are dysfunctional in cadasil through immunophenotyping of patient leukocytes and assessment of immunovascular interactions 3 can slxms resolve these dysfunctional phenotypes through the use of patient derivedipsc models and a zebrafish model of cadasil i will work with asst prof elahi mount sinai a leader in the field of vcid during the global outgoing phase including a secondment to the zhang lab harvard the effects of slxms in vivo will be explored in the return phase at the godson lab at ucdthis interdisciplinary proposal will merge my immunotherapeutic skillset with expertise of my mentorship team and cuttingedge technologies across several disciplines ipsc modelling bioengineering and therapeutics and will result in impactful discoveries for cadasil while generating significant european economic development and strengthening transatlantic research networks
cellulose lyocell filaments as a scalable solution for circular textile production

sustainable innovation in the textile value chain is difficult and time consuming as the industry is highly fragmented and specialized the intention is to form an umbrella across the value chain which allows to jointly define and push the boundaries of the most sustainable cellulosic filament currently available on a preindustrial scale lyocell filament as the starting point is at a trl5 pilot with key drivers and innovators being within the industry not in basic research the actual amount of relevant scientific as in basic research publications is rare lyocell filament has been introduced to the market in small volumes in 2017 but the development of the value chain and the overall market acceptance is still at an early stage lyocell filament has the potential to achieve this continuousfilament yarns or filament yarns are smooth to touch lacking the bulk of staple fiber yarns and can be used to produce a wide range of woven and knitted fabrics for various textiles and clothing the global filament market exceeds the global staple fiber market but is still vastly dominated by fossilbased nonrecyclable materials foremost pet and polyamide no significant innovations have been introduced on an industrial scale in decades however the environmentally friendly closedloop lyocell process has been established already in the early 2000s a europeanbased global innovator has developed a lyocell filament lf process to a state to improve both commercialization and sustainability with a consortium of key partners along the value chain the proposed innovation project aims to catalyze further development and validation of key production processes along the value chain to define business models and plans to enable market uptake within 12 years postproject ie by 2030
twinship integrated digital twin framework to enable green ship operations towards zero emission vessels

the twinship consortium is spearheading an initiative to transform the maritime sector by creating an alliance of premier maritime technology solution service providers ship design and shipping firms classification societies ports software developers and research and academic bodies this collaboration is centered around a unique opensource digital platform enriched with data and powered by domain knowledgebased advanced machine learning and artificial intelligence capabilities by introducing a digital twin dt enabled decision support system dss in the same digital platform twinship is setting a course for the maritime industrys rapid digital and environmental transformation the project sets ambitious benchmarks for reducing greenhouse gas emissions in international shipping aiming for a 3040 reduction by 2030 8090 by 2040 and achieving netzero emissions by 2045 all relative to 2008 levels by utilizing its pilot vessels and futuristic unmanned vessel concept this initiative focuses on leveraging both existing and emergent clean fuels and technologies prioritizing renewable energy sources and the implementation of unmanned vessels the twinship dtenabled dss is crafted to navigate the industry toward achieving these significant environmental targets demonstrating the consortiums dedication to fostering sustainability and pushing the boundaries of innovation
the first true minimallyinvasive spinal fusion system

over 1m spinal fusion procedures performed annually worldwide current spinal fusion procedures are highly invasive they are based on building screwbridges connected by metal rods stabilizing motion between vertebrae there are no effective treatments in the market that substitute the current invasive implants zlock is a small implant that resolves spinal fusion by eliminating the need for screws and rods zlock minimizes the invasiveness of procedures through a percutaneous approach where only a small skin incision is required for implant placement making it suitable for outpatient procedures zlock can revolutionize spinal fusion standard clinical practice and the market the implant value propositions have been confirmed in a first in human trial with the eic accelerator project zygofix will complete the necessary upgrades and clinical validation activities achieve cemark and accelerate the timeto market of zlock
phasematched nonlinear optics in layered semiconductors

light is one of the most powerful tools in our hands to study the world around us lasers have indeed revolutionized our daily life since they only work at a few fixed wavelengths it is crucial to convert their wavelength into the required one nonlinear optics provides essential tools to this end for instance second harmonic generation is a nonlinear process in which an intense input field at frequency generates a new field at the second harmonic frequency 2 the maximum efficiency of the nonlinear process is achieved by minimising the wave vector mismatch k ie the difference of the input wave vector at and the wave vector of the second harmonic at 2 achieving the socalled phasematching condition k0 birefringent phasematching bpm can be obtained in anisotropic nonlinear crystals with moderate nonlinearities few pmv alternatively quasiphasematching qpm makes use of periodicallypoled nonlinear crystals with larger nonlinearities 1020 pmv typical crystals for bpm and qpm have a large efficiency but macroscopic thickness ie millimetercentimeters and do not easily lend themselves to onchip integration pioneer aims at revolutionising nonlinear optics at the nanoscale achieving birefringent and quasi phasematching in engineered vertical stacks of layered semiconductors like noncentrosymmetric transition metal dichalcogenides 3rtmds which possess huge nonlinearities 1001000 pmv and promise to achieve the same efficiencies of bulk nonlinear crystals within micronthicknesses the goal of pioneer is the development of ultracompact onchip integrable nonlinear devices like entangled photon sources nanolasers and waveguides based on 3rtmds exceeding the performances of stateoftheart photonic resonators and nonlinear waveguides pioneer will initiate the field of phasematched nonlinear optics with layered semiconductors and will trigger the next revolution of integrated nonlinear optical devices
mechanisms of early language acquisition

successful communication in humans critically depends on two aspects of language development how many words we know vocabulary growth and whether we know how to combine them to understand and express meaningful ideas semantic organization this fellowship is designed to examine the role of early language environment in shaping these two aspects of language development this aim will be addressed by conducting a longitudinal investigation of lexical development between 9 and 18 months of age this will make it possible to map the structure of individual parents speech to the individual language development of their children the focus on individual development promises not only to advance our theoretical understanding of typical development but also to inform theorybased enrichment programs for atypical lexicosemantic development to achieve these aims the proposed research will strengthen connections between two fields in infant research language acquisition and semantic development additionally it will use a combination of complementary methods analyses of naturalistic language input parental reports experimental paradigms and cognitive modeling bridging the two research fields through a multimethod approach places this fellowship at the intersection of the fellows current expertise and the research lines currently active at the host institution bcbl specifically the semantic development aspect builds on the fellows strong background in category learning and lexicosemantic organization while the language acquisition part aligns closely with the bcbls research lines on the methodological side the fellow will bring expertise in experimental designs while skills related to the longitudinal approach infant research and cognitive modeling are those that the fellow will develop by training during this fellowship hence this fellowship will strongly support the development of the prospective fellows independent line of research
railway stations for green and socially inclusive cities

railway stations hold a unique position in the urban landscape they not only act as complex nodes of mobility and transport but also as public places that can be seen as integral elements of the city consequently stations have a decisive impact on their urban surroundings as places of everyday life affecting all stakeholders including citizens and the environmentthe central ambition of rail4cities is to develop a new operational readily available and highly applicable model of stations scp model combined with a common european methodology and tool for its effective implementation the project takes interdependent impediments profitorientated business model complex web of agents and stakeholders policy gaps into account and provides decision makers with the tools to transform stations into promoters of sustainable citiesthe model will be applied to 5 living labs addressing the stations transformation into hubs of green and active mobility fr energy hubs it towards transit oriented development de into a sociallyinclusive services hub with using nature based solutions pl and services hubs enabling the 15minute city and circular economy be this will be enhanced by 3 casestudies from the highspeed rail line from lisbon to oporto pt to study the resilience of infrastructures for both adaptation of spaces to new future uses and adaptation to climatechange issues and health criseswith 14 partners from 7 european countries further supported by 9 institutions through letters of support the rail4cities consortium and ecosystem integrates the relevant stakeholders from universities industry government and the public and is therefore in the position to design evaluate and publish a euwide model for transforming existing stations or designing new ones into sociotechnical systems operating as citys greening engines for the surrounding environment and new urban hubs aggregating multiple services for the users and its citizens