Dragon09/odtu_chatbot huggingface dataset:
sensing aberrant transcription by myc multimers

deregulated expression of myc or one of its paralogues mycn and mycl maintains the growth of most human tumors all current models explain the oncogenic potential of myc proteins by their ability to form complexes with max that universally bind to active promoters and the ability of these complexes to induce a tumorspecific gene expression pattern while myc conforms to this model during unperturbed cell growth we have discovered two paradigmatic situations in which myc proteins undergo fundamental changes in their biochemical state association with max and localization on chromatin in response to pharmacological or physical disruption of transcription elongation myc moves away from active promoters to form large spherical multimers that surround stalled replication forks these multimers contain transcription termination factors and form a zone that shields stalled forks from rna polymerase second mycn forms high molecular weight complexes during the s phase of the cell cycle that do not contain max and like myc multimers contain termination factors their assembly depends on rna that is normally degraded by the nuclear exosome arguing that they too form in response to aberrant transcription the switch between heterodimeric and multimeric states depends on nonproteolytic ubiquitylation of myc which alters proteinprotein interactions that retain myc at promoters our data show that myc proteins exist in a hitherto unknown dynamic equilibrium between globally promoterbound heterodimers and multimers that form locally in response to perturbed transcription we aim to show that these dynamics enable tumor cells to cope with stress arising from deregulated transcription and are crucial for mycs oncogenic function we expect that inhibiting myc multimerization will maintain normal growth but block the ability of tumour cells to cope with deregulated transcription and is therefore a valid therapeutic strategy for targeting oncogenic functions of myc
systemeu fostering systemic innovation and digital transformation across european innovation ecosystems

systemeu is an initiative aimed at transforming european innovation ecosystems through open innovation by fostering digitalization in healthcare energy and mobility it unites five regional ecosystems fostering inclusivity and collaboration among universities incubators public organizations government agencies and innovation centers from germany romania bulgaria bosnia and herzegovina and spain systemeu addresses the issue of traditional innovation efforts limited focus on societal and environmental transformation introducing a systemic and longterm perspective by fostering a collaborative and interdisciplinary environment systemeu will enable adaptable policies and stimulate economic vibrancy enhancing societal wellbeing and advancing european innovation systemeu promises to create interconnected inclusive and more efficient innovation ecosystems strengthen crossborder network collaboration through six crossregional projects in project duration and others after the project end expand global cooperation through existing networks of european actors and ecosystems promote gender equality and reduce territorial inequalities in access to innovation support aligning with eu policies and strategies systemeus innovative approach aims to usher europe into a regenerative world
accelerating proteins innovators beyond regulatory sandboxes

in the coming decades society faces the formidable challenge of providing sustenance for a global population expected to reach 10 billion by 2050 fortunately the burgeoning field of biotechnology holds significant promise in addressing this challenge by revolutionizing food production the central aim of this proposal is to pave the way for the widespread adoption of an innovative technology known as cellular agriculture which is poised to play a pivotal role in facilitating the global protein transition cellular agriculture in essence represents a breakthrough methodology for producing a spectrum of sustainable food productslead by 8 organisations from 7 countries representing the innovation ecosystem aprovals aims to facilitate the seamless integration of emerging cellular agriculture technologies into the global food landscape through two main activities sandbox for innovation aprovals offers a dedicated sandbox environment where innovators can test and refine their solutions this sandbox acts as a fertile ground for experimentation enabling startups and smes to develop their technologies and bring them to market interconnected stakeholders the project places a strong emphasis on fostering collaboration among key stakeholders involved in cellular agriculture1 startups and growing smes these enterprises are provided with essential support to advance their technologies and successfully navigate the journey from innovation to market2 innovation support tailored support initiatives are crafted to mitigate risks associated with the innovation process fostering a conducive ecosystem for cellular agriculture innovation3 regulators and policymakers aprovals actively engages with regulators and policymakers to establish robust protocols and a legal framework this framework serves to safeguard the market and consumers while simultaneously preventing unwarranted regulatory hurdles that could impede progress in cellular agriculture
responses of cetaceans to natural and anthropogenic noise

in the marine environment motorised vessels are now the most ubiquitous and pervasive anthropogenic noise source and the evidence for deleterious impacts from this noise source on sensitive marine life such as cetaceans whales dolphins and porpoises is mounting however cetaceans have not evolved in silent or naturally quiet environments and it may be hypothesised that animals have developed mechanisms to cope with naturally fluctuating noise levels regardless studies have yet to investigate whether individual cetaceans perceive and respond to motorised vessel noise in the same way as acoustically similar and significant natural noises such as rain for which they have been exposed to over evolutionary timescales in rain i will for the first time compare the responses of harbour porpoises a small odontocete cetacean to both motorised vessels and rain noise rain will 1 quantify the absolute contributions of rain and vessel noise to local marine soundscapes experienced by populations of harbour porpoises using longterm passive acoustic monitoring data 2 assess and compare the behavioural and acoustic responses of individual harbour porpoises to these noise sources using stateoftheart acoustic recording tags dtags and 3 investigate the effect of rain and vessel noise on individual echolocation performance as a proxy for foraging performance through rain i will provide new insights into how harbour porpoises perceive and respond to natural and anthropogenic noises at population and individual scales and identify quantify and compare potential coping mechanisms they employ to deal with these different noise sources results from rain will in turn providing evidence which will be used to directly inform the management of underwater noise levels and the protection of a key marine species in european marine waters
correlationsoriented representation learning

deep learning methods have propelled many of the recent remarkable achievements of artificial intelligence yet their inner workings remain enigmatic how do these methods represent the training examples in their multiple processing layers how are these representations used to make decisions on previously unseen data the correlationoriented representation learning coral project delves into the intricate relationship between data correlations and the hidden representations of deep neural networks corals core objectives encompass i characterizing the structure of data correlations in tasks where deep learning methods excel ii providing a theoretical description of the interplay between the learning dynamics of deep networks and data correlations and iii validating these theoretical insights on benchmark machinelearning datasets the researcher will approach these objectives with an effective mix of numerical experiments scaling descriptions and rigorous arguments inspired by statistical physics and fostered by the unique interdisciplinary scientific community of sissa by describing the impact of data correlations on representation learning coral holds the potential to enhance the interpretability and efficiency of deep learning methods across diverse domains while also enhancing our general understanding of the principles of learning from examples
the next generation of green resilient and socially inclusive smart cities

regreeneration is a publicprivate consortium including 9 european cities that will design experiment together for 4 years nature based solutions to regenerate deprived neighbourhoods for climate resilience ges reduction and local ecosystem dynamization through participative methods a set of mixed skills covering architecture landscape design geomatics and digital twins project value modelling urbanism nature public space facilities sociology economics will be deployed in different projects in paris fr barcelona es alverca pt bucharest ro followed by replicators located in roma it gent be ljubljana sl segrate it lappeeranta fi projects are complementary and will contribute to create a replicable knowledge on a large set of cities challenges how to regenerate quality of life health and attractiveness in marginalized areas bucharest paris how to capture carbon create freshness islands preserve biodiversity make a better usage of water develop low carbon mobility continuity prepare resilience to stressed weather events alverca barcelona paris how to educate and make local actors inhabitants municipality agents local businesses political authorities participate to design maintain the green areas created the nine cities how to analyze the diversity of local contexts to choose the right best practices to replicate in a european territory and define the required investment governance model roma gent ljubljana segrate lappeeranta the knowledge to successfully create for meeting these challenges will focus on some key concepts 1 creation of an indepth territory analysis unifying multiple planning domains and able to simulate evolution scenarios 2 extensive use of 15 mn methodology and pedestriangreen mobility focus to support life quality and impacts analysis 3 permanent integration of local climate resilience challenges at each key milestones of the project
digital health in circular economy

dice aims to develop and demonstrate novel circular and environmentally sound solutions to design collect directly reuse refurbish remanufacture and recycle digital health devices epaper label smart wearable sensor smart pill box endocutter which will contribute to enabling a circular transition solutions will be implemented tested and demonstrated in five healthcare ecosystems reflecting the geographical spread within europe through communityengaged pilots in norway belgium slovenia spain and germany dice will contribute to mitigating the globally expanding health waste problem covering three material streams electronics plastics metal and alleviate shortage of critical and valuable raw materials while protecting the health and safety of those involved in realising the circular economy exploitation of key outputs will be ensured by all partners throughout and after the project and will be further extended to adjacent sectors through existing networks and platforms within which the partners are represented
deciphering metastasis of lung cancer to brain and developing new therapeutic approaches via a human metastatic cascade platform

brain metastases have a poor prognosis and are associated with a high morbidity and mortality rate in cancer patients the metastatic pathways and the role of the bloodbrain barrier bbb during metastasis are not known there is a need to better understand cancer brain metastasis and develop effective therapeutics with metabrain i will create a humanbased in vitro platform that spans the entire cancer cell journey from lung to brain and use it to address three key questions 1 how does cancer metastasize to the brain 2 what is the role of the bbb in cancer metastasis to the brain and 3 how and when can cancer metastasize be treated the metabrain will provide answers to these questions by developing a truly physiologically relevant human cellbased model that for the first time maps the entire cancer metastasis cascade and that can also be used to study novel target proteins at the bloodtumor barrier btb this model will also be used to develop novel shuttle systems for drug delivery to the brain by integrating stateoftheart technologies from life sciences and engineering metabrain has three main objectives 1 develop an in vitro model that recapitulates the metastatic cascade with in vivolike morphology and function to study how cancer metastases to the brain 2 investigate the role of extracellular vesicle ev and circulating tumor cell ctc migration events with a focus on their interactions with brain endothelia and 3 identification of novel target proteins specific to cancerous brain and development of novel nanoshuttle systems targeting these proteins to deliver therapeutics to the brain in summary metabrain will lead the way in the development of physiologically relevant models for other braininvasive metastatic cancers open new avenues for the development of therapeutic and diagnostic approaches and pave the way for nanoshuttle formulations specifically designed to overcome the bbb and btb
which moral influences on european penal and prison policies

the justpen project aims to analyse the strategies private interest groups use to try to influence european penal and prison policies through notably litigation and judicial complaints lodged with the european court of human courts and the court of justice of the european union in relying notably on a current national research grant on the european human rights justice under moral influences the justpen project will analyse whether or not the moral and religious values promoted by these private interest groups have influenced and have even been taken account of or even been adopted by the european penal and prison policies in this respect the project will investigate the ways in which these private interest groups try to influence these policies using doctrinal judicial notably through litigation and monitoring efforts and political tactics in terms of effects of these strategies we will investigate how and to what extent these tactics are translated into penal and prison policies notably through a process of coercive human rights that refer to the coercive aspect the enactement of criminal law and the use of criminal sanctions of human rights protection in doing so we will propose a new theoretical model the moral entrepreneur of jurisprudence that is all about powerful private actors who do not behave as philantropists but are driven by material interests taking creative initiatives which involve shaping or reshaping case law on penal and prison policies in doing so they can either reinforce or on the contrary moderate and even lenify the coercive dimension of human rights and contribute though this process to orient significantly penal and prison policies the justpen project intends thus to achieve a significant paradigm shift within the existing literature on human rights european law and penal and prison policies by combining all these domains that are ignored by the existing legal sociolegal and criminological literature
advanced high pressure and costeffective pem water electrolysis technology

direct production of highly pressurised hydrogen from electrolytic water splitting can allow saving relevant amounts of energy compared to downstream gas compression the aim of this project is to develop a novel polymer electrolyte membrane pem electrolyser able to produce hydrogen at very high pressure 200 bar thus reducing the postcompression energy consumption another goal is to develop a costeffective technology allowing to achieve largescale application of pem electrolysers a significant reduction of capital costs is achieved by critical raw materials minimisation developing cheap coated bipolar plates and operating the electrolyser at a high production rate while assuring high efficiency about 80 vs hhv and safe operation advancepem aims at developing a set of breakthrough solutions at materials stack and system levels to increase hydrogen pressure to 200 bar and current density to 5 a cm2 for the base load while keeping the nominal energy consumption 50 kwhkg h2 reinforced aquivion polymer membranes with enhanced conductivity high glass transition temperature and increased crystallinity able to withstand high differential pressures are developed for this application the approach is to operate the innovative membrane at high temperature 90120 c under high pressure to allow increasing energy efficiency to mitigate hydrogen permeation to the anode and related safety issues efficient recombination catalysts are integrated both in the membrane and anode structure the new technology is validated by demonstrating a highpressure electrolyser of 50 kw nominal capacity with a production rate of about 24 kg h2day in an industrial environment the project will deliver a technoeconomic analysis to assess reduction of the electrolyser capex and opex the consortium comprises an electrolyser manufacturer membrane and catalyst supplier an mea developer and an enduser for demonstrating the system
dynamic resilience assessment method including combined business continuity management and cyber threat intelligence solution for critical sectors

the scope of dynamo is to combine the two fields of business continuity management bcm and cyber threat intelligence cti to generate a situational awareness picture for decision support across all stages of the resilience cycle prepare prevent protect response recover professionals of different backgrounds will work together with endusers to develop refine and combine selected tools into a single platform in alignment to enduser needs human factors high ethical standards and societal impacts dynamo includes the following goalsresilience assessment as basis for bcm an assessment with different levels of detail offers with varying existent data a fast or detailed evaluation of the investigated sector and helps to identify critical processes enduser data will be integrated to measure determined performance targets with respect to the functional description aibased approaches will be used for a deeper understanding and potential selflearning of the interconnected process the results generate knowledge concerning susceptibility and vulnerability of the investigated sector the solutions support the bcm with respect to the five resilience phases leveraging cti cti will be improved with respect to existing solutions h2020 echo panacea the h2020 early warning system ews will be extended and integrated a malware information sharing platform misp will be used to raise the situational awareness between different security actors the cti approach deliver data that will be integrated into the resilience and bcm approach the use of ai will support the development solutions will be integrated with the cyber knowledge graph to visualize the analysis of threat intelligencethe dynamo platform will be able to collect organizations skills data elaborate and create custom tailored organisational training to improve organisational resilience which will be demonstrated within three different crosssectoral usecases
corporate political power how business actors define the rules that govern their responsible behaviour

in this cuttingedge project i ask the research question how do business actors define the transnational rules that govern corporations responsible behaviour extending insights from political science and management studies the central objective of this research project is to enlarge the scope of actors activities and processes being studied and reveal more nuanced ways through which corporations exert power in and over political rules this main objective is operationalized into four working packages wp1 aims to synthesize the existing literature on corporate power in and over rules the other wps elucidate three indirect and often overlooked types of corporate political power ie power in and through global production networks gpns wp2 big four consultancies wp3 and trade associations wp4 to this end i create a novel dataset of national and international governmental csr policies from different countries international organizations and regional organizations in all major world regions spanning a 65year period by drawing together data from different online platforms in wp2 i measure the similarities between different governmental csr policies based on cosine similarity as a result of backward and forward gpn participation in wp3 i code the authorshipof these csr policies and the degree of similarities with publications by the big four consultancies in wp4 i send out a largescale survey to trade association representatives to ask about their lobbying on the csr policies within my dataset to further unpack the causal relations of wp3 and wp4 i also conduct indepth interviews by drawing on management theories on how companies govern global markets and political theories on the functioning of governments i ambitiously move this research agenda forward in an interdisciplinary manner this helps to overcome the treatment of either business or politics as blackboxes while also bridging the analytical macromicro divide
urban biography of a cosmopolitan african capital

the project aims at writing an urban biography of tungul old dongola sudan the use of the native nubian designation of the city underscores its medieval african heritage while the biographical approach aids in conceptualizing the city as a complex living organism tungul was originally the capital of the kingdom of makuria which transformed into a citystate under the patronage of funj sultans 16th19th cent makuria was a medieval african kingdom that thrived in the middle nile valley from the end of the 4th cent to the late 15th cent ce this project is a multidisciplinary attempt at gaining a profound understanding of settlement persistence in riverine africa and it intends to amass extensive documentation of a medieval and premodern city the biography will be based on analyses of tunguls urban design and planning built structures material culture bioarchaeology as well as micromorphology and geochemistry the results will significantly contribute to the nubian datasets and offer new perspectives for broader archaeological and theoretical studies on urbanism and complex societies the proposed biography will focus on three entangled and mutually inclusive research themes the capitals cityscape its design and planning the citys inhabitants climate and environment the project intends to venture beyond the traditional narratives steeped in either ecological or political determinism to create a balanced narrative devoting equal attention to climatic environmental socioeconomic and political factors the majority of work will focus on the collection and analysis of data on tungul in the makurian period 4th15th centuries however the research objectives require combining this material with data for the funj period 16th19th centuries which constitutes an outcome of the erc starting grant umma and with other information obtained through decades of excavations to consolidate the results of all research conducted at tungul