Dragon09/odtu_chatbot huggingface dataset:
a companion magnetic sensor for in operando detection of magnetic biosynthesis in cancer and neurodegenerative models

iron is essential for all life forms as it is a core component of many vital metabolic processes in humans iron homeostasis is controlled by sophisticated processes regulating its storage transport and export more recently the role of iron in diseases also emerged with ferroptosis being a form of cell death that is implicated for instance in the onset and progression of cancer or neurodegenerative disorders here we focus on another intriguing type of iron in the body the magnetic iron which seems to be involved in both homeostasis and crippling pathologies but which goes largely unnoticed to date and yet the presence and role of such biomagnetic iron offer a significant opportunity for novel therapeutic approaches one explanation as to why this an unmet need most certainly stems from the lack of existing technologies that can detect the signature of biomagnetic iron in live human cells in real time the solution brought by biomag poc project is to make possible the in operando monitoring of intracellular biogenesis of magnetic iron in human cells in advanced cancer and alzheimers models to do so the project proposes a unique ultrasensitive magnetic sensor integrated with bioreactors to enable the realtime measurement of magnetic nanoparticles biosynthesis in the cellular environment the usefulness of this device goes well beyond the scope of our main erc research as it can have a significant impact on i identifying novel therapeutic approaches to diseases by detecting ironbased new druggable targets ii addressing key questions related to iron metabolism towards novel diagnostics and iii proposing a novel type of biogenic nanomedicines
viscoelastic interactions of the brain tissue with braincomputer interfaces

iict is an autonomous institute within the bulgarian academy of sciences the vibrate project aims at enhancing the scientific excellence of iict and its capacity to gain competitive research funding by establishing an era chair focused on a better understanding of the interactions of implants with the brain tissue and the technologies to interface the human brain ie braincomputer interfacing bci and deep brain stimulation devices the highlevel scientific objectives of the action are to i investigate the viscoelastic coupling between the brain and implanted electrodes ii optimize the interface geometry for invasive and noninvasive bcis iii model and investigate diffusion of substances around implants iv model the mechanical effects on recorded brain activity the chair will open an experimental bci lab which will test model predictions in brain tissue phantom models and will close the loop between theory and experiment the action will also establish a project management and technology office that will support the longterm funding strategy of the chair and stakeholder interactions the longterm ambition of the action is to enable the formation of a bulgarian hightech pole in neurotechnology the prospective chair relies on the combined expertise of the era chair holder in neurotechnology and mathematical modeling with the relevant expertise in neural network models and scientific computing and signal processing already available at the host the vibrate chair will allow for the formation of a group with top expertise in bulgaria which will participate as an equal partner in international research programs and will become a central knowledge hub for neurotechnology in the country
hyperpv the first gpupowered physical verification framework with high performance computing capabilities

electronic design automation industry has been a crucial driving force behind the growth of the semiconductor industry nowadays chips have extremely complex designs as they need to be verified and tested before the manufacturing to avoid huge respin costs and additional expensive engineer hours eda companies deliver tools assisting semiconductor companies in addressing complex design automation challenges currently eda is not able to cope with the everevolving semiconductor industry and the need to boost the calculus capacities in particular current eda tools based on cpu technologies are energyinefficient expensive and take long times for results to this extent amsimcel is developing hyperpv the first gpupowered physical verification framework based on a high performance computing design rule checking engine which will disrupt the eda market by solving current bottlenecks of the design lifecycle hyperpv can be accessed through a saas cloud platform
physics accuracy and machine learning towards the nextgeneration of molecular potentials

weak intermolecular interactions are the driving force of relevant processes including protein folding charge transfer through solid state junctions in solar cells and collisions in interstellar gas clouds understanding the nature of these forces is essential to achieve better control and optimization of these processes nowadays modelling has become an essential tool for unravelling experiments and aiding materials design however the accurate description of weak interactions is plenty of challenges for many theoretical approaches atomistic simulations can help decipher the mechanisms underlying complex processes nonetheless precise molecular potentials are required to achieve a quantitative and qualitative description of these physicalchemical processes despite the importance of this field there is at present no systematic and comprehensive training in this subject particularly in the fundamentals of the theory method development techniques to rigorously test the theory using experimental data and the creation of new models using detailed physical understanding combined with machinelearning the phymol network aims to fill in this fill this gap by bringing together a group of experts in the field of chemical physics intermolecular interactions simulation and machinelearning with several industrial and academic partners this program will exploit the synergies between an accurate description of intermolecular interactions and the use of machine learning techniques towards the generation of new molecular potentials combining scientific investigation with an intensive training program phymol will help shape a new generation of researchers with the capability of developing accurate molecular potentials impacting a broad range of applications
the early ticking of the central circadian pacemaker when and how

the 24h circadian timing system develops during the perinatal period and rules our physiology later in life it has the essential task of anticipating daily recurring changes in the environment daynight to find the best time for each molecular and cellular process it is organised hierarchically with a master pacemaker in the hypothalamic suprachiasmatic nucleus scn which is able to perceive environmental light and tell the body what time is it our modern 247 lifestyle favours a disruptive environment for the circadian system which is especially negative during pregnancy we have found in mice and preterm infants that when mothers are exposed to glucocorticoids gcs at the wrong time of day the offspring show behaviour disorders later in life our mechanistic findings showed for the first time a role of the foetal clock before birth challenging the view on the clock being immature and nonfunctionalstarticking proposes to answer a longstanding question in the field when and how the circadian clock starts ticking with a multidisciplinary and integrated approach we will go beyond the stateoftheart to understand mechanistically the development of the central circadian pacemaker in mice and humans we will investigate 1 how the scn forms by a detailed assessment of the developmental trajectory of the mouse scn with single cell resolution 2 when the scn becomes functional by testing a yet unexplored player astrocytes as drivers of the gain of functionality of the mouse scn3 what the influence of the early environment on the human scn maturation is the generation of a human scn organoid will allow us to test maternal signals in vitro with highthroughput we will link mechanistic findings to the development of scndriven rhythms in a cohort of preterm babies starticking will provide groundbreaking mechanistic evidence and valuable knowledge to alleviate the behavioural consequences of the circadian disruption early in life
lownoise rapid and ultrabroadband terahertz timedomain ellipsometry enabled by spintronic terahertz emitters

electromagnetic radiation in the terahertz thz frequency range 0330 thz is a powerful tool for material spectroscopy and characterization in a contactfree nonionizing and nondestructive way an essential application is the contactfree measurement of the complexvalued reflectivity and ideally refractive index of materials such knowledge is essential in condensedmatter research for characterization of eg the conductionelectron concentration and scattering in semiconductors of optical phonons in insulators and magnons in antiferromagnets and in applied settings ideally thz reflectivity measurements should be 1 ultrabroadband covering two decades from 03 to 30 thz 2 userfriendly and offer 3 high precision and low noise however requirements 13 are not fulfilled by current approaches the goal of tspindex is to build a prototype thz timedomain reflectivity spectrometer to determine the thz refractive index of materials rapidly features 13 are achieved altogether by using an innovative laserdriven coherent thz source a spintronic thz emitter
sco2 operating pumped thermal energy storage for gridindustry cooperation

sco2optes project aims to develop and validate up to trl5 in unigetp lab the next generation of powertoheattopower p2h2p energy storage able to guarantee long duration and large scale energy storage to facilitate bulky res integration in eu energy systems as well as to enhance fossil based power plants flexibilization and facilitate grid integration of eu industries sco2optes promotes indeed a new paradigm where industrial wh even at low temperature like 150200c can be used not only to produce power via orc or sco2 cycles but to operate p2h2p storage systems more efficiently and grid flexibly the consortium is composed by innovative smes and acknowledged eu rtos motivated to realize the first sco2 ptes pilot plant in europe leveraging experiences from previous eu funded projects sharpsco2 co2olheat solarsco2ol etc as well as from acknowledged rtos unige cvr kth polimi certh uob and industrial partners edpp edpnew heron sco2optes the potential of sco2 based carnot batteries based on innovative molten salt tes kyoto rpow and sco2 hexs al and turbomachinery enogia sit targeting to assess the potential benefit of valorising local wh to optimize roundtripefficiency and reduce tes sizecapex while optimizing local gridpower plant flexibility needs via its pilot and replication campaign involving further ccgts in greece and portugal sco2optes promotes the role of p2h2p as key enabling long durationlarge scale energy storage technology to boost res integration in eu energy systems pcteco will develop and validate key enabling technologies hexs turbomachinery tes and modelling approaches dynamics thermoeconomic grid flexibility potential assessment to make eu leader in the field of p2h2p solutions boosting wh recovery as well as fostering a storage solution based on rotatingmachine and therefore more grid flexible and environmentally friendly if compared to battery or powertoh2 storage solutions
european research infrastructure for heritage science implementation phase

the european research infrastructure for heritage science erihs was designed as a paneuropean distributed infrastructure with the vision of replacing the traditional scienceforart approach to conservation through the new widely interdisciplinary sector of heritage science hs to improve the understanding and sustainable preservation of cultural heritage erihs was admitted in the 2016 esfri roadmap and is now preparing its step 2 application to take the legal form of an eric the erihs implementation phase erihs ip consortium brings together representatives of the national nodes of the countries that expressed their willingness to support the establishment of the eric and one permanent observer it aims at enabling the erihs implementation phase and preparing the operation of erihs eric also in support of its positioning as the reference ri for the hs domain at the eu and global level the objectives and methodology underpinning the erihs ip work plan target and intend to overcome the bottlenecks highlighted in the recommendations of the 2020 esfri monitoring report the ec high level expert group report 2020 and the eric step 1 assessment 2021 coordinated actions are dedicated to i implement the erihs governance structure and finalise its distributed architecture ii support the erihs management with strategies and related implementation plans regarding hr procurement risk management and quality system iii maintain and build upon the established erihs excellence in user access and foster fair open access with the design of the digilab platform iv strengthen international cooperation cultivate synergies and consolidate the hs community around erihs while establishing erihs in the landscape of eu ris and global initiatives v secure the eric sustainability and unlock its socioeconomic impact potential by providing erihs with an updated business plan and a marketing strategy tailored for its new lifecycle phase
articular cartilage treatment with injectable hydrogel is valuable and longterm effective

hy2care brings a regenerative injectable hydrogel of joint and cartilagemimicking composition that is used to treat damaged cartilage the cartilage defects are easily filled with a syringe during a standard one time arthroscopy the hydrogel fill the defect prevents ingrowth of scar tissue and allows the body to heal itself by creating true hyaline cartilage ensuring an optimal regenerated tissue the highquality regeneration provides the basis for a long lasting repair postponing or even preventing the onset of osteoarthritis the gel binds covalently to the surrounding cartilage ensuring integration of the new tissue revalidation is fast as the cartilage regrowth follows the degradation of the gel the lasting repair not only prevents additional secondary treatments but also pain disability and escalating followon costs in submission of the last cut off of the eic in october 2020 hy2care scored a 140 and recieved the seal of excellence
aware systems for smart interactive museums and art

artificial intelligence ai is transforming the world we live in in the last decade deep learning algorithms have enabled ai systems to perform tasks like speech and image recognition matching or surpassing human capabilities however ai will not be enough to deliver humanlevel intelligence without a sort of artificial awareness that could provide the ability to focus its computational resources and intelligently control them to interact with people in a socially competent manner this project streams from the eic pathfinder project astound ga 101071191 which is currently developing an integrative approach for awareness engineering to establish consciousness in machines the requested booster grant will support the commercial validation of astounds new contextually aware chatbots in the tourism sector identified as a potential initial target market in fact exploiting novel contextually aware chatbots in the tourism sector could offer immediate and impactful benefits as tourists often require realtime contextspecific information and assistance which these advanced chatbots can effectively provide additionally the chatbots could pave the way for the future museum a museum that could become like a thematic park in which visitors could really appreciate the value of onsite visits vs virtual visits by for example generating an emotional link with the original piece of art to explore the pathways to commercialise this breakthrough innovation the project has set the following objectives 1 conduct market analysis and productmarket fit assessment to validate the commercial viability of deploying the novel contextually aware chatbot in the tourism sector and 2 finetune a demo of the astbased chatbot using datasets specifically tailored for the tourism sector
the psychogeography of intergenerational mobility early life socioeconomic position mental health and educational performance

surging inequality is a defining feature of the world children grow up in today the neighborhood they live in stages a primary developmental context where this feature of our present time plays out childrens demographic and socioeconomic status ses is given by the status of their parents parental and neighborhood ses is associated with child mental health and educational performance and childhood is a vulnerable period to understand how and why early life socioeconomic position is linked to mental health and educational performance i propose a groundbreaking paradigm generalizing temporal spatial social genetic and individual levels of inference i will do this by having genomically similar children growing up in different families at different places at different times these multitudes of counterfactuals will allow me to jointly evaluate hypotheses on selection and causation and risk and protection factors for mental health and academic outcomesthe geogen study will render a new understanding of a how transmission of risk is transmitted across generations b how early mental health is an antecedent of academic failure c the interactions between genetic risk and protective contextual factors and c characteristics of schools and neighborhoods that are optimal for childrens psychological developmenti will use norway since 1940 as a laboratory n8 400 000 with registries giving full genealogy and yearbyyear event data on place of residence indicators of ses mental health and educational performance within this i will nest a populationbased cohort study comprising genotyping of families n240 000 in 110 000 families and a wide array of survey data such as noncognitive skills the combination of having data on all people in all schools and neighborhoods over time allows me to do an unprecedented study on the geneenvironment interplay between risk and protective factors for mental health and academic outcomes
uspace air and ground risk models enhancement

uagree aims to develop an integrated risk model linking the operations of unmanned aircraft uas with some negative effects they may have with regard safety security privacy and environment this risk model is intended to support the airspace risk assessments required by uspace european regulation as well as an amendment to sora methodology so that risk can be quantitatively estimated enabling digital implementations leading to swifter operational approval processes moreover the uagree risk model will account for uspace services to mitigate the risk thus reducing the burden of meeting the sora operational safety objectives and unleashing operations and business models which are currently economically unviable to achieve these goals uagree will start by identifying realistic scenarios where uas operations will take place and will assess them to identify all the hazards that these operations can pose to safety security privacy and environment next the project will agree metrics and thresholds to measure the risk due to these hazards with relevant stakeholders especially civil aviation authorities and common information services providers afterwards the team will develop mathematical models linking the hazards with their effects either on the ground or in the air and will define mitigation barriers using uspace services as well as algorithms to quantify their effectiveness in terms of risk ratios these models will be integrated into stateoftheart uspace simulators to evaluate the applicability and relevance of the proposed integrated risk model in the representative scenarios previously identified by the project to synchronise the project outcomes with the uspace deployment a first version of the risk model addressing short term needs will be delivered one year after the project kickoff whereas a second version addressing mid to longterm needs eg urban air mobility or variable demand will be delivered at the end of the project
development of sociality and social relationships and maintenance of social structure over generations in the closest evolutionary relatives of humans the great apes

sociality is an evolved trait which forms the basis of primate societies it influences individual survival reproduction access to information and disease transmission as earlylife experiences have longterm consequences knowledge of individual developmental history has contributed well to understanding the factors that underlie variation in individual health longevity resilience to internal and external stressors amongst other crucial aspects of an animals life therefore studying aspects of individual development is fundamental to understanding how individuals become welladapted to their environment great apes live in complex societies with constantly changing opportunities for associations and interactions for which they make complex cognitive decisions just like humans as they are our closest evolutionary relatives longterm developmental studies on them are indispensable to understand how the development of the social life of humans evolved national and international collaborations focused on data and knowledge sharing for comparative studies on great apes will help to overcome the current gaps in our knowledge about human social evolution the future fellow will collate two decades of finescale observational data collected on individually identified great apes from birth until the start of adulthood from four great ape projects the aims are to 1 investigate at the individual level the development of sociality and social relationships 2 investigate at the population level social inheritance of social structure over generations and 3 develop a general theory of social structure maintenance this action will be the first to take a largescale dataintensive and comparative approach to studying the social life of immature great apes using a combination of cuttingedge computational tools and analytical methods the results of this action will bridge fundamental gaps in our knowledge of hominidae sociality and social structure
a novel combination treatment effective against all multidrugresistant pathogens deemed as a critical priority by the who

antimicrobial resistance amr due to multidrugresistant gramnegative bacteria are an increasingly serious healthcare threat exacerbated by major economic issues underlying the development of new antibacterial drugs the effectiveness of lactam antibiotics the most important class of antibacterial agents is impaired by the production of lactamase enzymes by drugresistant bacteria we are developing a combination of a wellknown antibiotic meropenem and ant3310 our proprietary bestinclass serinelactamase inhibitor intended for the treatment of hospitalacquired infections caused by drugresistant pathogens our treatment has been preclinically proven to be efficacious against all three pathogens deemed a critical priority by the world health organization whowe will conduct three clinical trials and next outlicense ant3310 to a pharmaceutical partner we expect market approval by 2029 and that ant3310 will generate over 10bn in sales within 13 years