Dragon09/odtu_chatbot huggingface dataset:
greenhealthsafety nexus for new urban spaces

in our increasingly anthropised planet many cities are facing multiple societal and environmental challenges and the link between the characteristics of the urban green contexts and peoples health and safety represents an emerging topic and of urgent importance air pollution and urban climate reduced contact with nature limited access to quality green spaces and urban fabrics and infrastructure that discourage sustainablesafe mobility and active lifestyles are threatening the mental and physical wellbeing of an aging society and increasing its social disparities the greenexus project proposes a novel and multidisciplinary approach to promote urban greening territorial regeneration and safetyaccessibilitywalkability of urban infrastructures as key strategies to face those challenges while addressing climate change and preventing pandemics from exacerbating inequalities in disadvantagedvulnerable groups the greenexus participants 20 institutions from 9 european countries are joining forces to offer a collaborative trainingthroughresearch programme involving universities research centres companies ngos and local authorities that share this new vision of fostering greener healthier and safer urban realms of europes cities and towns this will drive the greenexus process to train specialists whose cuttingedge and intersectoral expertise will be developed and managed through a challenging general programme of training that combines and integrates the various fields of innovative knowledge of the greenexus participants and also includes career planning entrepreneurship and soft skills training in terms of research 10 specific and multidisciplinary topics will be addressed by 10 doctoral candidates who are envisaged to spread the greenexus approach beyond the projects scope and duration under the guidance of a supervisory group of academic and nonacademic experts
an integrated experimental and mathematical approach to investigating endothelial barrier integrity in health and cerebral malaria

the integrity of the endothelial barrier is vital for maintaining healthy brain function and is especially compromised in pathological conditions such as cerebral malaria despite its significance the current understanding of the mechanochemical mechanisms operating at subcellular intercellular and tissue scales within endothelial barriers during cerebral malaria remains limited this project aims to close this knowledge gap by integrating advanced in vitro experimental methods with multiscale mathematical models through a multitiered methodologyincluding singlecell assays 2d endothelial monolayer cultures and 3d brain microfluidic deviceswe plan to assemble a comprehensive dataset that captures the complex mechanochemical processes underlying endothelial function and dysfunction this rich dataset will facilitate the datadriven development calibration and validation of a new multiscale mathematical model along with a highperformance computational framework for its solution the validated models will subsequently be used to design targeted experiments aimed at dissecting the molecular mechanisms regulating endothelial integrity our interdisciplinary approach is uniquely poised to cultivate a dynamic interplay between experimental data and mathematical modelling leading to a more holistic understanding of the mechanisms responsible for endothelial integrity in healthy states and how they are compromised in the cerebral malaria condition ultimately this strategy aims to provide an indepth understanding of the endothelium which could in the long term aid in the development of therapeutic interventions for cerebral malaria
it takes two to tango2 unravelling the role of syntrophic interactions in the evolution of anaerobic eukaryotes

living without oxygen is challenging to live in lowoxygen environments some microbes exchange nutrients allowing for a division of labor among individuals in a process called syntrophy such interactions are often a prerequisite for prokaryotes living in these environments whether syntrophy is necessary for the survival of microbial eukaryotes protists is unexplored and yet critically important to discerning the roles of eukaryotes in nature and how eukaryotic cells adapt to live without oxygentango2 will test the hypothesis that syntrophic partnerships allow eukaryotes to thrive in anaerobic environments and underpin the evolution of key eukaryotic cell biological characteristics this will be accomplished using stateoftheart genomic computational and experimental approachesi will discover genes essential for interactions between a model protist and its ectosymbiont using massivelyparallelized transposon mutagenesis this will discern the molecular mechanisms metabolic interplay and selective forces dictating eukaryoteprokaryote interactionsi will deliver metagenomes of cultured anaerobic eukaryoteprokaryote consortia predicted to be engaging in syntrophic interactions this will drastically expand our knowledge of the biodiversity of eukaryotic genomes and microbial interactions from lowoxygen environments i will interrogate the frequency and diversity of syntrophy in eukaryotes by simultaneously sequencing the genomes and transcriptomes ofindividual protist cells and their microbiota sampled from nature this will provide the first elucidation of what communities coexist with natural anaerobic protistsunderstanding how syntrophic interactions have influenced eukaryotic cell biology will reveal hidden connections in the complicated functional networks of the eukaryotic cell tango2 will open research avenues by bridging the fields of evolutionary cell biology and microbiology to understand ancient and recent symbiotic
validated local risk actionable data for adaptation

the eu aims to transforming 150 european regions into sustainable and climate resilient regions by 2030 valorada contributes to address this challenge by codeveloping tested fair customizable datamanipulation tools to access available climate datasets and to enable the sharing community validation and use of locally socioeconomic demographic and earthobservation data in a rigorous transdisciplinary approach the respective risks of climate change are analysed in five demonstrators in europe with the local actors data required for the analysis are compiled from the various already existing repositories eg climate data store and locallysourced nonclimate data catalogues processed by local communities and regions prototype analysis tools developed in an iterative process tested by the actors and subsequently improved we will codevelop and make available prototype climate data and nonclimate data manipulation tools to support and improve existing data portals and platforms and to enable useroriented multidata integration valorada aims to reach trl 7 and above valoradas tools will enable to acquire different useful climate and nonclimate data and make them interoperable in terms of metadata as well as tools able to harmonise the geographical and time references chosen for the data analyst toolbox will be composed of tools able to combine different kinds of data all relevant for assessing climate risks and to calculate resulting indicatorsvalorada will contribute to scaling up to 150 regions through the implementation of dedicated scalability and replicability activities with at least 10 european regions and through strong collaboration with other horizon projects additional activities include capacitybuilding schemes for end users as well as providers of climate services valorada will explore and assess the options to facilitate the connection of the valorada data tools to the copernicus atmosphere data store
excellent science with impact open and reliable

excelscior will develop extend and fully unlock the research potential of the university of coimbra uc portugal through the implementation of a new interdisciplinary era chair devoted to metaresearch ie research on research or metascience metaresearch fosters reproducibility and interdisciplinarity making science more efficient through better use of research data more reliable through better verification and ultimately more transparent open and responsive to societal challenges and needs excelscior strategic goal is thus to improve ucs research methods and practices and enhance approaches to integrate information generate reliable evidence and maximize its impact in order to increase the scientific production quality and organizational praxis of research innovation at uc towards euera excellence biomedical sciences will be the era chairs primary target during the projects execution but the intrinsic nature of metaresearch is seemingly apposite and will then continue to revolutionize and advance multiple other research areas within uc and beyond the named era chair holder professor john ioannidis from the university of stanford is considered a pioneer in metaresearch being one of the ten mostcited scientists globally across all sciences his work in the field attained worldwide recognition and has transformed research in biomedicine and multiple other scientific areas under his leadership this era chair will strive and in the long term evolve into a new research to action center the metaresearch innovation center coimbra metric c bound to operate in tandem with the metaresearch innovation center at stanford metrics and its sister in berlin metricb both of which cofounded and codirected by professor ioannidis
development and manufacturing of forestbased membranes for electrochemical energy devices

emerging technologies such as proton exchange fuel cells pemfcs and redox flow batteries rfb are expected to contribute to societys transition towards renewable energy however these technologies use toxic pfsabased membranes which have caused serious ill effects on human health and the environment in fact the overall health cost due to pfas usage is estimated to be between 52 and 84 billion per year as a result of this the eu is placing restrictions to ban the substances which initial bans already commencing this has resulted in major companies such as 3m announcing to stop all production of pfasbased materials by 2025 a decision worth 2 billion usd annually to overcome this cellfion has developed a biobased ionselective membrane derived from natural cellulose the first of its kind this innovation is 27 times more costeffective compared to the competing solution while providing the potential for increased performance
black widow antivenom innovation necessity

widow spiders are spread worldwide and their bite induces severe envenomation symptoms that can lead to a complex syndrome known as latrodectism and death in severe cases the only available specific treatment consists of polyclonal antibodies derived from horse plasma obtained by hyperimmunization with black widow spider venom however this process is slow dangerous and implies the continuous use of large domestic animals mainly horses in the manufacturing process venom unavailability is a significant supply chain bottleneck in antivenom manufacture which imposes a very high product cost also the efficacy of this horsederived product suffers from batchtobatch variation resulting in variable efficacy profiles for different batches finally the nonhuman nature of the horsederived antibodies may provoke severe adverse immunological reactions the high prevalence of adverse reactions severely limits its use and antivenom use is thus reserved for only the most extreme cases while not being administered at all to the many patients with asthma atopy or other allergyrelated conditions we are developing a recombinant antivenom based on a single broadlyneutralizing fully human monoclonal antibody that can neutralize the toxic effects of widow spider bites according to who nomenclature this antibody will be called latrotoxumab and it will be safer to administer more efficacious as well as costcompetitive with existing antivenoms in this erc poc project which is based on results obtained in the erc stg project mabster grant number 850974 we will explore the commercial potential of latrotoxumab and lay the first foundation for a spinoff company fang pharma by securing in vivo poc securing ipr developing a regulatory manufacturing and clinical trial plan and preparing a fullyflexed business plan incl market pricing and swot analyses identification of business growth opportunities partners and investors and exit strategy
nerve growth factor delivery into the brain focus on therapeutic potential in alzheimers disease and in vivo evaluation via pet

alzheimers disease ad is a neurodegenerative disease affecting the aged population and is projected to increase 3fold in the next 30 years treatment options in ad are limited due to complex pathological processes and the bloodbrain barrier bbb which restrict entry molecules into the brain a finding in ad is the loss of cholinergic neurons tropomyosin receptor kinase a trka and its substrate the nerve growth factor ngf are involved in neuronal survival and have been evaluated in small clinical trials as a therapeutic intervention in ad advances in bbb shuttling methods in which antibodies and enzymes can be transported over the bbb make ngf a possible treatment option in adwithin this proposal i will develop novel methods for the delivery of ngf into the brain two different approaches for bbb delivery of ngf will improve the success rate in one approach ngf will be delivered into the brain by transferrin receptor tfrmediated transcytosis ngf will be chemically conjugated to a tfr binding antibody using a linker that selectively and quantifiably can release ngf in its native form in the brain ensuring retained biological activity an alternative approach bbb will be opened with focused ultrasounds allowing passage of ngf into the brain positron emission tomography occupancy studies with 18ftrack a trka selective tracer will be used to evaluate in vivo binding of ngf to trka the abovedescribed bbb transport methods for ngf will be evaluated in longterm therapeutic study using 5xfad mice pharmacodynamic readouts will be changes in brain amyloidbeta levels neuroinflammation parameters and improved memory and cognitive functions in this project i will expand my knowledge in bbb delivery of macromolecules learn new radiolabeling techniques from a worldleading radiochemist and novel develop the necessary skills to take my career to the next level
flexoelectric control of magnetic textures in 2d oxide membranes

freestanding layers of complex oxides are a completely new generation of 2d materials which exhibit a plethora of coupled responses and endow 2d materials with robust correlated groundstates in this project we explore the control of magnetism in a freestanding oxide driven by the coupling of its ferromagnetic groundstate to strain induced polar structures enabled by the freestanding formdeterministic control of magnetic textures namely skyrmions is an exciting area of research for its potential to impact computing and information technology however the metallic nature of most ferromagnetic materials renders the direct control by electric fields impractical due to screening by free carriers developing approaches to direct electric control of ferromagnetism in a single material remains a virgin land to exploreflexomag aims at the use of strain induced flexoelectricity in a metallic oxide with strong spin orbit interaction srruo3 to nucleate spin textures skyrmions and skyrmion lattices flexoelectricity enables the creation of a polar structure in the presence of strain gradients and is expected to impact magnetic ordering via direct coupling of spins with a polar structure by spinorbit coupling moreover strain gradients will act as effective electric field and would not suffer from the cancellation by screening due to free charges flexoelectric control of magnetism is in itself an important breakthrough in fundamental science and it will further yield a completely novel strategy to tailor spin textures we will use twistronics of 2d oxides to design skyrmion lattices never observed before in oxides skyrmions and skyrmion lattices are acclaimed information vectors sought in the design of next generation magnetic memories this research will supply a long sought technological platform to fabricate skyrmions by design
sourcing hydrogen for alternative mobility realising opportunities and creating know how in ireland

sh2amrock irelands emerald hydrogen valleysh2amrock will deploy green hydrogen across key hardtoabate sectors across the island of ireland including key infrastructure to enable the production distribution and use of green hydrogen the 5 yearproject with a total investment of approximately 80m will showcase the capacity of h2 to maximise penetration of res through sector coupling while facilitating widespread integration of renewable h2 into irelands energy system sh2amrock will realise this goal through the deployment of the countrys first hydrogen valley and multimodal h2 transport hub in galway accelerating the island of irelands energy transition and decarbonisation across multiple enduser applications
patient lifestyle and disease data interactium

neuromuscular disease is at the forefront of collecting realworld demographic and clinicallyrelevant data from patientspaladin a public private partnership will leverage treatnmds global registry platform this uses patient data to support clinical trial planningrecruitment as well as more complex regulatordriven studies with other partners expertise in patient engagement and fair data this a public private partnership will develop the interactium a new integrated approach to patient datathe interactium will align registryreported data with patient reported outcomeexperience measures and other data eg wearables and internet of things devices and share the collated holistic data to improve outcomes and decisionmaking and accelerate innovation for a range of stakeholders patients regulators industry and initiatives like darwinpaladins other objectivesdevelop a patient interface to collect patient preferences to support an inclusive approach and to allow visualization of data and control over its useprovide classleading tools to support all stages of decisionmaking in translational research care and diagnosis across the neuromuscular field and develop standard operating procedures to allow utilization across the rare disease and wider health fieldsto provide communications and shared learning outside the neuromuscular disease field to support scaleup development of similar systems and capabilities across all diseasesdeveloping a patientcentric and costeffective advanced integrated healthcare solution requires well defined patient groups in significant but manageable numbers extensive ongoing research and trials and drugs at all stages of development neuromuscular diseases provides all of these however the interactium and associated processes and frameworks have much wider potential a system that can ingest data from any relevant source align that data at patient level and provide data analysis to support decisionmaking by patients clinicians regulators and healthrelated industries is equally relevant to more common diseases such as diabetespaladin key deliverablesflexible interactium omni data platformarchitecturetemplate for an improved user experiencearchitecture for wearable infrastructurenovel methods for fairification processtoolkit for rare disease patient organisations
innovative approach to an individualised tcell immunotherapy for cancer using personalised tumour trained lymphocytes pttl that is reliable costeffective scalable and easy to implement

neogap has developed a groundbreaking personalised adoptive t cell therapy for treating solid tumours based on two proprietary technologies pior machine learning software and epitcer this cancer immunotherapy consists of producing personalised tumour trained lymphocytes pttl which are autologous tcells harvested from regional lymph nodes subjected to a neoantigendriven tcell stimulation technology to deliver highly tumourreactive tcell clones pttls pttls are reinfused to the patient where they infiltrate and kill cancer cells leaving healthy cells untouched the therapy is broadly applicable to many cancer types being personalised to each individual patient in this eic accelerator project neogap plans to complete a phase iiia clinical trial of the therapy in advanced colorectal cancer patients focused on safety assessment and biomarker exploration and optimise the manufacturing process for the next clinical studies
the spatial organization of gene regulation in embryonic development

master transcription factors tfs cooperate with chromatin in regulating genomic activity in animal development and stress response local clustering of tfs into dense submicrometer size condensates is emerging as a key feature of transcriptional regulation this includes intranuclear condensates formed by pioneer tfs during development transient clusters of rna polymerase ii complex and nuclear stress bodies formed during a heat shock despite the ubiquity of these assemblies we know little about the biophysical mechanism of their formation or physiological function the last years have seen the development of new frameworks to study such transient assemblies including various types of phase transitions and tools to probe and modulate them however this work has been limited mainly to cell culture and in vitro experiments that failed to incorporate the vital role of chromatin in organizing gene regulation i propose a crossdisciplinary strategy consisting of a novel in vitro assays and functional studies in a nematode caenorhabditis elegans to study the spatial organization of transcription in embryonic development and stress response the specific aims are1 understand the physiological relevance of transcriptional condensates in animal development and stress response2 determine the molecular composition and regulators of transcriptional condensates 3 dissect the mechanism of transcriptional condensate formation using a novel chromatin carpet assay we will use stateoftheart microscopybased tools to investigate the formation and function of nuclear condensates in developing animal embryos and develop innovative assays to probe the condensation of tfs on the surface of purified native chromatin the obtained results will provide an unprecedented insight into the composition assembly mechanism and physiological relevance of biomolecular condensates formed by the transcriptional apparatus during differentiation and stress response