Dragon09/odtu_chatbot huggingface dataset:
actions required to secure the largescale deployment of the leading cdr approaches to meet eu climate targets

the rising concentration of co2 in the atmosphere currently about 420 ppm is already causing extensive damage globally thus theres an urgent need to deploy co2 removal cdr at very large scale to help to keep the temperature rise under 2c 15c would be better until recently apart from academic research into a wide portfolio of approaches little has been done to launch the necessary exponential growth of cdr over the next few decades the current selfregulated market relies on an unsatisfactory patchwork of thirdparty verification of the removals achieved at individual sites the sector has been negatively influenced by a lack of regulation and highquality standards this has allowed lowquality carbon credits to enter the market lowering credibility and prices to levels at which highquality permanent removals cannot compete the member states need the ec to intervene to kickstart a transparent and properly regulated market for highgrade cdr delivery the purpose of the csink project is to deliver to the ec a complete package of workedup proposals to support a new or amended european legalregulatory framework to bring high quality cdrs into the market that package will contain prestandards in cen format covering requirements and methodologies for sampling testing and qms iso9000 upon which to build monitoring reporting and verification systems it will also include proposals to cover a environmental socialimpact and governance issues and b the means of building trust in the market this will encourage entrepreneurs to demonstrate effective and safe cdr projects and to make large investments thus allowing the market to evolve to tackle the climate crisisthe csink consortium includes organizations from 11 countries with complementary skills and expertise in the different cdr technologies the writing of cen and iso standards climate law carbon trading and in all of the relevant environmental and social issues
tuning of photonic resonators

silicon photonics has progressed enormously over the last 15 years large microelectronics manufacturers and small companies are now working on the subject with identified products the reproducibility of micro and nanophotonic devices remains a central technological barrier to be broken the dimension errors of cleanroom devices are 1 to 10 nanometers 1 limiting applications we have discovered a technique that makes it possible to absorb these errors at the end of manufacturing permanently we can tune photonic resonators with an accuracy of 104 and make them strictly identical when necessary in this poc project the patented technique will be transposed on silicon devices of interest in a simple configuration for manufacturers
setting the optimal balance between metabolite supplementation and deprivation in cancer therapy

the goal of this proposal is to explore combinations of targeted metabolite supplementation and global nutrient restriction as a new strategy to reprogram tumor metabolism to halt tumor progression and to improve response to treatments preclinical and clinical studies published by our group and by others showed that global nutrient restriction in the form of cyclic fasting or fastingmimicking diets fmds produces desirable metabolic and immunologic effects that result in reduced tumor progression and in the prolongation of animalpatient survival of note our unpublished results indicate that the supplementation of specific amino acids or fatty acids has in vitro and in vivo antitumor effects which are strongly enhanced when metabolite supplementation is combined with nutrient starvation by employing canonical cell biology and biochemical experiments polysomeribosome profiling isotope tracing experiments and integrated omics transcriptomic proteomic metabolomic analyses in in vitro and in vivo murine and human tumor models here we propose toidentify the cellautonomous and immunemediated mechanisms at the basis of the antitumor effects of targeted metabolite supplementation in combination with global nutrient restrictionidentify the most effective metabolite supplementationrestriction strategy to be tested in a firstinhuman clinical trial in patients with advanced triplenegative breast cancer while the basic cancer research and medical oncology communities are engaged in a historical scientific and clinical diatribe on the use of nutrient deprivation vs supplementation approaches to halt tumor progression and to improve patient survival we will exploit our unprecedented ability to conduct parallel preclinical and clinical experimentation in the field of cancer metabolism to identify new and effective combinations of balanced metabolite supplementation and restriction with relevant scientific and translational implications
investigating genderbased discrimination unveiling the underlying mechanisms

according to feminist theories that have approached gbv social changes related to globalization intersect with etiologies of violence against women vaw the causes of vaw no longer stop at national borders for more than 15 years the integrated socialecological theory has evolved as a theoretical model for exploring the factors associated with vaw the primary research will investigate the relationship between basic cognitive functions decisionmaking and emotion regulation need for cognitive closure sexist beliefs and acceptance of gender stereotypes taking into consideration the culture in mind theoretical framework on adherence to and perpetuation of genderbased discrimination gbd through its implicit stereotypical manifestations vaw is one of the major public health problems worldwide world health organization data reported that approximately one in three women worldwide has been a victim of violence the research project will be structured around four overarching objectives 1explore adherence to gender stereotypes in the reference sample 2identify the relationship between cognitive variables that lead to stereotypical thinking to understand which relationships are strongest 3investigate which models explain the relationships between cognitive variables and stereotypical thinking 4make a comparison between italy and lithuania to investigate possible cultural differences although the patterns of gbv differ across cultures the fact that it is a worldwide phenomenon leads to the hypothesis that there are factors that outweigh the cultural aspects that allow discriminatory stereotypes to persist therefore the project aims to integrate into a single theoretical and innovative model the factors that most seem to be related to adherence to gender stereotypes a policy recommendation will be prepared based on research findings the innovative aspect of the project lies in an inclusive approach to gender equality seeking prevention of gbd
social sciences participatory researchaction for preparedness in risk management for disasters and health emergencies in europes cities

disasters including health emergencies pose enormous strains on response capacities of cities countries and the european union compounding existing climatic political economic and social challenges the risks and consequences of these emergencies reduce the health and wellbeing of europes inhabitants but their burdens are not evenly shouldered across all populations cities face huge challenges in preparing for and responding to disasters urban publics not only suffer higher morbidity and mortality during such emergencies but resulting instability and response measures can exacerbate social and health inequalities vulnerable urban inhabitants are at risk during such crises for exclusion and heightened health consequences with lower access to health information resources care and support they tend to experience higher mortality and morbidity and longerterm reductions in health the goal of sonarcities is to render europes cities more resilient in health emergencies and disasters through the cocreation and implementation of a communitybased adapted toolset for people facing vulnerabilities first responders and decisionmakers by strengthening inclusivity in risk management we will enhance preparedness and reduce risks posed by these emergencies we will analyze one health factors and consequences of past emergencies in 6 european cities notably from the perspectives of people experiencing vulnerabilities we use these analyses to cocreate with publics at risk first responders and authorities a citizencentered toolset which will generate inclusive preparedness improve health literacy and crisis communication strengthen capacity and decisionmaking and reduce risks of disastershealth emergencies in european cities we will disseminate the toolset through our interactive knowledge platform and offer a social sciences emergency support network for authorities seeking social sciences assistance during health emergencies and disasters
biobased pyrazine monomers from second generation biomass for high performance polymers copolymers and blends

the sustainable product initiative sets a challenge for european industries to create sustainable products considering environmental impact durability recyclability and safety biopyrania introduces a groundbreaking approach using a new class of biobased pyrazine monomers they will be synthesized from glutamic acid and 5amino levulinic acid that are on their turn obtained via fermentative processes starting from european second generation woody biomass as already proven by the recent work on pyrazine based polyesters in the labs of maastricht university the incorporation of pyrazines gives unprecedented properties including the potential for added chemical functionality and improved material characteristics through nontraditional hydrogen bondingbiopyrania will use this knowledge to develop new classes of pyrazine based polyamide and polybenzimidazole polymers copolymers and blends in a safe and sustainable way from lab to pilot scale these pyrazinebased materials have the potential to revolutionize highperformance applications with a focus on the automotive and green hydrogen sectors with the electrification of the automotive industry lightweight highperformance materials are more and more crucial and biopyrania polyamides are promising candidates in the green energy market there is a growing demand for clean hydrogen production electrolyzers and fuel cells play a key role in this process and biopyrania aims to enhance the performance and sustainability of anion exchange membranes that are used therein with pyrazine based polybenzimidazoles recycling of these materials will enhance their circularity profilethe developments will be supported and accelerated by digital methodologies environmental toxicological technoeconomic and social impact studies the biopyrania consortium is a robust partnership of 2 acas 2 rtos 7 smes and 2 industrial partners
novel light regimes and drought effects on temperate forest plant biodiversity

tree canopies are one of the most recognizable features of forests providing shelter from external influences to a myriad of species that live in the understorey canopy disturbances are now accelerating across european forests and climatechange induced drought is a key driver these disturbances are opening the canopy and exposing forest biodiversity to noanalog light regimes and drought light and drought levels they have never been exposed to before as the majority of forest plant species occur in the shade below tree canopies the combination of altered light regimes and intensifying droughts can strongly impact forest biodiversity however the interactive effects of novel light regimes and drought on temperate forest biodiversity have never been investigated before since recent european droughts are unprecedented in the last two millennia and this has initiated the largest pulse of forest disturbances in almost two centuries the time to assess impacts on biodiversity is now the overarching aim of canopychange is to quantify understand and predict the impacts of noanalog light regimes and drought on belowcanopy forest plant biodiversity to address this challenging goal crosscontinental resurveyed vegetation plots the first paneuropean forest disturbancedrought experiment and a pioneering canopy clipping mesocosm experiment will be combined with an interdisciplinary toolbox drawing from ecology forestry and climatology these data will then feed into cuttingedge joint species distribution models to project european forest plant biodiversity responses to future climate and canopy change canopychange will be the first integrative study of paneuropean forest plant biodiversity responses to noanalog light regimes and drought canopychange is at the heart of biodiversity conservation and forest management and will deliver muchneeded information for policy makers and managers to adapt to the future noanalog conditions in european forests
evaluation of thermohydraulic characteristic of printed circuit heat exchangers in pseudocritical region for supercritical co2 cycle

currently 282 of the total eu28 greenhouse gas emissions come from the power sector a large contributor to greenhouse gas emissions consequently the emphasis of the research in power generation has swung towards assessing highly efficient and greener power cycles in this reference the novel supercritical carbon dioxide brayton cycle sco2bc is an ideal choice that outstrips other formally wellknown power cycles brayton rankine cycles in sco2bc the role of the precooler is critical it serves as a sink to the power cycle and regulates the conditions at the compressors inlet the compressors inlet temperature is intended to be maintained close to the critical temperature of carbon dioxide co2 to achieve greater cycle efficiencies however exceptionally higher values of the specific heat capacity of co2 near its critical point up to 40 times higher than water require exceedingly high water flow rates on the cold side to achieve the desired exit temperatures of co2 consequently the precoolers pumping power requirements become high enough to deteriorate the cycles performance this problem can only be mitigated by exploring new channel geometries with enhanced thermohydraulic characteristics therefore the proposed study plan to characterize the complex thermohydraulic characteristics in the pseudocritical region of co2 using a multifaceted technique that includes experimental numerical and machine learning techniques the proposed work will provide a step forward to the success of sco2bc technologies that in turn will facilitate its integration with the green energy resources generationiv nuclear reactors and solar concentrated plants helping to meet the eus 2030 climate and energy framework goals of achieving at least 32 share for renewable energy
interneurons gating of aversive or rewarding information from the basolateral amygdala to ventral hippocampus

the ability of neuronal networks to process and store information relies on the activity of diverse subclasses of inhibitory interneurons ins while the importance of inhibition in controlling key features of network function is being increasingly appreciated the understanding of the role of ins in neuronal networks function is limited by the incomplete knowledge of the connectivity between the different in subclasses and pyramidal cells such gap of knowledge is even more evident when considering the connectivity between ins and engram cells ie subgroups of pyramidal neurons encoding specific memories in this conceptual framework the ingate project will analyze specific amygdalohippocampal circuits involved in valence coding where memories of stimuli imbued with negative or positive valence segregate in different engram cells in the bla ingate will test the hypothesis that two broad ins subclasses the parvalbumin pv and somatostatin sst expressing ins differentially gate aversive or rewarding information from the bla to the ca1 region of the ventral hippocampus to this end i will analyze the functional connectivity between bla aversive or rewarding engram cells formed during fear or reward conditioning to pyramidal cells and pvsst interneurons in vca1 in parallel i will study vca3 schaffer collaterals converging on those vca1 pyramidal cells and pvsst interneurons that receive inputs from the bla aversive or rewarding engram cells thus the ultimate goal of ingate is to clarify how pv or sst interneurons shape engram cells in vca1 by integrating valencerelated information from bla and multisensory contextual information from the vca3 area ingate will combine several stateoftheart methodological approaches to generate identify and manipulate aversive or rewarding bla engrams and isolate their targets in vca1 in addition it will exploit an in vivo approach to measure population activity of excitatory and inhibitory neurons in vca1
cocreativity and learning interactive opus generation for piano education

learning to play a musical instrument such as a piano requires many hours of exercises generally either suggested to the student by a teacher or taken from a method book these books are collections of progressive exercises meant to teach specific techniques and address the commonest mistakes and difficulties that players face while learning one downside of these books is that the exercises are not personalized to the students and thus cannot address specific difficulties and characteristics of each learner teachers could potentially write or find exercises that are tailored to the different needs of their students but this activity is very timeconsuming and given the number of students that many teachers have it becomes prohibitive given the many recent advances in the field of music generation we propose that it should be possible to generate exercises automatically to form a personalized method for each student the teacher would describe the characteristics of the student and their strength and weaknesses to a software system as well as the teaching goals that should be covered in the generated exercises in return the system would create a sequence of exercises that are specific to the needs of the student and to the concerns of the teacher this interactive opus would allow for a more effective and engaging learning experience since the learning difficulty curve would follow each student rather than enforcing a general curriculum in caliope i propose to study both a theoretical model for the description of piano learning students and a computational system to generate progressive exercises based on that model advancing knowledge in computational creativity and music generation to tackle longterm structure this project will aim to create an entire set of musical exercises that are coherent in style and difficulty leading research towards music generation that is useful to human musicians
an aipowered visual assistive design iot pathway platform to implement fast and optimal automated patient pathways and healthcare demand planning projects

mysphera has rolled out a game changing iot location solution to track and manage patient pathways in real time it automates the surgical process by means of tailored applications that empower staff with live patientflow data and notifications as a result the solution has obtained references in several eu countries that note a significant capacity increasedeploying this solution takes few months of codesign work with the hospital which limits its scaleup potential we aim to reduce the effort and time by an order of magnitude falling from months to just a few days an aipowered visual assistive design iot pathway platform based on spatial process mining and machine learning technologies has been prototyped to complete this radical leap by streamlining the design tailoring and deployment of optimal pathways and elective care planning projects for any hospital unit and in a matter of days
fluently the essence of humanrobot interaction

fluently leverages the latest advancements in aidriven decisionmaking process to achieve true social collaboration between humans and machines while matching extremely dynamic manufacturing contextsthe project results will be 1 fluently smart interface unit and 2 the robogymthe fluently smart interface unit features 1 interpretation of speech content speech tone and gestures automatically translated into robot instructions making industrial robots accessible to any skill profile 2 assessment of the operators state through a dedicated sensors infrastructure that complements a persistent context awareness to enrich an aibased behavioural framework in charge of triggering the generation of specific robot strategies 3 modelling products and production changes in a way they could be recognized interpreted and matched by robots in cooperation with humans robots equipped with fluently will constantly embrace humans physical and cognitive loads but will also learn and build experience with their human teammates to establish a manufacturing practise relying upon quality and wellbeing the bond between human and robot is personalized and it is established during a preliminary training at the robogym the first european hub for humanrobot interactive training where human and robot learn from each other a common work practice fluently will be validated by demonstration on three full scale pilots characterized by various level of automation production dynamism and complexity of the manufacturing decision making processthe total project value required to commercialize the fluently device and robogym concept is 188 m eur forecast for ebitda in 2028 is 163 m eur payback in 2028 with 13 gross profit and roi 91 in line with sectorial performances the new turnover generated requires at least 325 workers employed along the fluently supply chain fluently will bring together 21 key industrial and academic stakeholders from 13 countries
clinical validation of nanopl a hydrogelbased formulation of a small molecule for a highly targeted therapy against glioblastoma multiforme gbm

glioblastoma gbm is considered the highest unmet need in oncology the average life expectancy of gbm patients is 1218 months and the 5year survival rates remain below 7 despite the efforts the available therapy today counts only with a few ineffective approved therapiesusing a machine learning algorithm we have discovered a correlation between a small molecule and an unexplored target in gbm we have developed a hydrogelbased formulation of the molecule with great safety and efficacy in vivo our formulation showed 40 longterm survival in a gbm rat model with complete tumour eradication after a single dose treatment nanopl is a onetime treatment applied locally during surgery which is effective even in gbm cells that are resistant to the standard of care or those involved in recurrence nanopl also showed a synergistic efficacy with temozolomide standardofcare the eic will enable the clinical validation of nanopl completely unlocking the gbm treatment
cheaper better batteries from common safe and available raw materials

electrification of transport and transition to renewable energy generation are essential to cut our carbon emissions in half by 2030 batteries are a key component to allow this change but they also remain a major bottleneck in the scaling of green technologies battery production relies on raw materials like lithium cobalt and nickel all of which are already in short supply yet the green boom is just beginning to enable our green future the battery industry needs a revolutionbroadbit has developed fundamentally new sodiumbased battery technology for highperformance batteries made from low cost and widely available raw materials we have redesigned the entire battery chemistry and developed new safe and clean dry production processwith the help of eic we will finalize our cell chemistry finetune the production processes and strengthen partnerships to consistently reach commercial quality and cycle life targets required for successful market introduction and scale up