Dragon09/odtu_chatbot huggingface dataset:
graphenebased artificial iris for active light management in a smart contact lens

smart contact lenses have the potential to address multiple medical unmet needs such as vision correction diagnosis of eye disorders and monitoring of biomarkers for instance liquid crystal lc cells controlled by smart electronics and embedded inside contact lenses can autonomously control light intensity and visual acuity for patients suffering iris disorders however a couple of technological challenges remain unresolved before patient validation the properties of lc cells are not optimal when using standard materials such as pedotpss and ito the former reduces the transmittance while the sheet resistance of the latter is greatly affected by thermoforming steps in addition lc ionic currents need to be reduced to favour power consumption the gaia project will address these limitations by introducing a graphenebased artificial iris the unique combination of properties of graphene ie mechanical robustness high transmittance and lower ionic introduction make it an ideal material for eyerelated smart applicationswe will combine the artificial iris management technology based on lc cells already developed by azalea with the graphene microfabrication techniques developed by icn2 to deliver medical optical systems with ultralow power consumption and unprecedented transparency and flexibility the graphene artificial iris will autonomously change the size of the pupil to control the depth of field visual acuity and improve the quality of life of millions of people our consortium brings together all the key expertise to achieve the project goals azalea is an sme with expertise in active light management stretchable electronics and electronics integration in contact lenses while icn2 is a top academic research centre with unique knowledge in flexible graphene electrodes fabrication together we will develop and validate the next generation of smart contact lenses to bring a revolutionary product to the market to solve unmet medical needs
novel co2based electrothermal energy and geological storage system ceegs

ceegs co2 based electrothermal energy and geological storage system is a crosssectoral technology for energy transition with a renewable energy storage system based on the transcritical co2 cycle co2 storage in geological formations and geothermal heat extraction it is a highly efficient costeffective and scalable smallto largescale concept for largecapacity renewable energy storage extended capacity is obtained due to the underground system it can be integrated into the grid heating and cooling districts and industries it also has the capacity for partial co2 sequestration the main objective of the project is to provide scientific proof of the technoeconomic feasibility of the technology raising the current low trl 2 to trl 4 by addressing gaps in the interface between surface transcritical cycle and the subsurface co2 storageceegs follows a 3phase approach i from theoretical principles to models simulations and processes in which advanced numerical simulations integrate reservoir behaviour wellbore design and surface plant design ii from models and simulations to systemsexperimental verification addressing ceegs integration and efficiency in energy systems with digital functional and laboratory models developed and components validated with results from the co2 pilotscale projects and iii social economic and sustainability assessments where social acceptance studies lca and tea tools evaluate impacts and concept deployment with renewables hardtodecarbonise industries district heating and cooling or in grid balance the project is completed with wp1 for coordination and wp7 for results dissemination and exploitation the project integrates the knowledge and networks for a successful implementation in 3 years with a consortium with partners from 5 eu countries with multidisciplinary skills on energy systems energy storage geology geothermal systems and co2 geological storage
decoding metabolic effectors in plant stress response and acclimation

the european commission aims at promoting agricultural innovation while preserving biodiversity and without increasing arable land surface understanding how plants respond to stress is therefore vital to design new improved agricultural solutions that meet these requirementsgeneral and conserved plant stress responses to pathogens rely on systemic propagation of calcium ca2 signalling and reactive oxygen species ros from the site of attack to distant organs an unexpected essential link between primary metabolism ie nadph production longdistance ca2 signals and ros propagation was recently brought to light thus opening a new line of fundamental research ie the metabolic regulation of plant stress signalling and suggesting that modulation of nadp metabolism can boost plant defencesdemetra decoding metabolic effectors in plant stress response and acclimation aims at obtaining a deep characterization of this metabolic regulation of plant signalling in response to bacterial pathogens by combining biochemical and cuttingedge imaging techniques this project will produce a thorough characterization of the nadph production mechanism and of the perturbations of longdistance signalling caused by a shortage of nadph finally it will allow engineering new solutions to improve plant stress responses against pathogens by acting on nadph metabolism thus demetra will quickly advance fundamental research on plant stress signalling and guide biotechnological applications to improve conserved natural defence mechanisms in crop plants
transnational fatherhood negotiating masculinity and parental care in the digital communication era

the research proposal aims at investigating the relationship between transnational fatherhood negotiation of masculinity and parental care practices among pakistani migrant men in italy the migration patterns prompted by socioeconomic factors traditional gender roles and improved quality of life in certain regions have led to a surge in migration predominantly by men this study seeks to explore how transnational fathers navigate their roles across family work and society and use digital communication tools to maintain family connectionguided by an intersectional perspective and innovative methodologies this research project focuses on the experiences of pakistani migrant men the research objectives include investigating the impact of transnational fatherhood on the construction and negotiation of masculinity exploring the role negotiation of migrant fathers understanding the interplay between migration masculinity emotions and transnational fatherhood and analyzing how digital communication technologies influence fatherhood and care practicesby focusing on pakistani migrant men this research addresses a critical gap in the literature surrounding masculinity fatherhood and emotional care in light of the statistics revealing the substantial influx of male migrants particularly from south asia this project becomes pivotal for addressing thisthe research design employs a variety of qualitative methodologies including indepth interviews focus group discussions observations and content analysis the primary and secondary sample respondents consist of pakistani migrant men with and without families in italy italian natives interacting with pakistani migrants field experts and other stakeholders the sampling strategy involves purposive selection and aims to achieve data saturation this project aims to shed light on the complex dynamics of transnational fatherhood masculinity and parental care in the digital age
highly ethanolselective electrocatalytic co2 reduction enabled by sitespecific heteroatoms doped single atom catalysts supported cu clusters

electrochemical co2 reduction reaction co2 rr driven by renewable power is a promising way to convert co2 to fuels and chemicals which has been proposed as a sustainable process for the artificial carbon cycle among all products ethanol c2h5oh has received extensive attention because it can be directly used as fuel in internal combustion engines and industrial power generation cubased catalysts can efficiently promote cc coupling toward c2 products in co2 rr however most cubased catalysts still show an insufficient selectivity for c2h5oh 50 due to unfavorable adsorption of several oxygencontaining key intermediates which cannot achieve its commercial value as a frontier in materials science singleatom motifs anchored on ndoped c support carbonbased sacs are widely investigated due to their maximum atomutilization efficiency and highly metal dispersion especially in the field of eco2 rr compared to the pure nc sacs exhibit an excellent co selectivity because of the easily optimized coordination environment along with a reconstructed structure therefore combining sacs with cubased catalysts in the proper configuration can increase the local co concentration near cubased materials at a low overpotential where cu alone would be incapable of doing the co2toco conversion meanwhile the moderate electrondonating ability of sacs will further stabilize the oxygenic c2 intermediate to make the hydrogenation pathway toward c2h5oh production more favorable as a result the objective of this project is to design a carbonbased sacs supported cu clusters architecture by a chemical insitu growth process to let it serve as a highefficient catalyst for achieving a high c2h5oh selectivity 75 at a low overpotential 800 mv this project will set the scene for the fabrication of highly efficient and commercially available electrodes for the eco2 rr to production of c2h5oh
establishing design rules for creating collagenlike materials with specific mechanical stability and response colmec

every day our bodies endure myriad mechanical forces that influence proteins especially collagen at the molecular level colmec aims to use collagen as a model to uncover the nuances of protein mechanochemistry a central aspect of this research is deciphering how collagens evolutionary adaptations influence its response to forces especially in contexts of aging and disease this pursuit is split into three distinct objectives 1 investigating the coevolution of collagens amino acid residues to decode its response to tensile forces 2 delving into the role of metal ions in collagen crosslinking drawing parallels with natural phenomena such as the resilience of mussel byssus and 3 probing the mechanisms of force propagation within collagens varied structures merging bioinformatics computational biophysics and materials science colmecs interdisciplinary approach illuminates how evolution shapes protein defenses against mechanical strains this knowledge is pivotal in establishing design rules for crafting synthetic collagenlike materials with tailored mechanical stability and response bridging evolutionary insights with innovative material design
modelling restoration of wetlands for carbon pathways climate change mitigation and adaptation ecosystem services and biodiversity cobenefits

restore4cs aims to assess the role of restoration action on wetlands climate change mitigation capacity and a wide range of ecosystem services using an integrative socioecological systems approach focusing on coastal wetlands across europe restore4cs will deliver standardised methodologies and approaches for the prioritisation of restoration promoting carbonstorage and greenhouse gasses ghg emissions abatement while improving the ecological status and the provision of additional ecosystem services such as flood regulation and coastal erosion protection project results will support the implementation of climate and biodiversity policies in the context of the european green deal effectiveness data on restoration and land use management actions on climate services and other ecosystem and socioeconomic services will be gathered both from six case pilot sites across european coastal areas including wellpreserved altered and restored wetlands and from metaanalysis models and integrative assessment tools will be upscaled to wider geographical european and ecological other wetland types including floodplains and peatlands contexts using remote sensing and machine learning methods to develop an integrated status assessment of european wetlands the results will be integrated into a digital platform to serve as a decision support system dss for stakeholders that will steer project efforts as part of a newly created community of practice around wetland restoration
the neuroscience of human tickle perception

tickle is one of the most enigmatic human sensations we do not know how a touch can turn into tickle and why our brain responds to other peoples tickles but not to our own to date there is no theory that can satisfactorily explain why touch on certain body areas feels more ticklish than on others and why some people are more prone to be tickled compared to others despite this fundamental knowledge gap experiments on tickle perception have been extremely scarce and there is currently no active research on the topic at an international levelin ticklishuman i propose a new interdisciplinary approach to understand the neuroscience of human tickle perception based on modern haptic technology somatosensory psychophysics multivariate pattern analyses of neuroimaging data brain stimulation and advanced statistical modelling techniques first my team and i will establish a stimulation protocol that optimally induces tickle sensations and we will identify their neural profile building upon my findings on how the brain differentiates between selfgenerated and externally generated touch we will delineate the body maps where the perception of tickle is amplified and we will determine the brain mechanism that cancels selfgenerated tickle sensations finally we will model individual differences in tickle perception as a function of central peripheral personality and demographic characteristics ticklishuman has the strong potential to radically transform our scientific and popular thinking about the social motor and clinical neuroscience of tickle the novel insights from the project will permit to explore the very undervalued clinical and functional implications of tickle in the next decades including its use as a cognitive biomarker in schizophrenia and autism and its evolutionary function across species
flexibility for hydrogen

the project aims at moving technological frontiers for lowemission combustion of hydrogen to fuel modern gas turbines at high firing temperatures and pressures beyond the latest stateoftheart this will be achieved whilst maintaining high engine performance efficiency fuel and load flexibility without diluents at the same time all emission targets set by the clean hydrogen ju strategic research and innovation agenda sria will be metthe idea is based on a proprietary combustion technology designated constant pressure sequential combustion cpsc already deployed into the gt36 hclass engine 760 mw in combined cycle the cpsc concept based on a unique longitudinally staged combustion system yields the best fuel flexibility and has the greatest potential to achieve the project target of demonstrating stable and clean combustor operation with concentrations of hydrogen admixed with natural gas up to 100 at firing temperatures typical of modern hclass engines the new improved combustor design will be fully retrofittable to existing gas turbines thereby providing opportunities for refurbishing existing assetsthe primary objective is to demonstrate the cpsc technology in engine relevant environment trl6 in three steps 70 90 and 100 vol h2 in this pursuit a subset of specific performance data kpis will be met within the project timeline and with the planned resources and allocated budgetthe project uses stateoftheart computational tools analytical modelling and diagnostic techniques to investigate static and dynamic flame stabilisation testing is performed at worldclass laboratories in test campaigns at reduced scale and in full size at atmospheric and pressurised conditionsin preparation for commercialisation the project will also develop a roadmap towards deployment of the developed system into operation and demonstration into a power plant environment quantifying the valuable contributions to the eu green deal
engrams in traumatic memory finding novel therapeutic avenues in depression and ptsd

despite 70 of people are going to experience a traumatic event throughout life only 39 are going to develop posttraumatic stress disorder ptsd curiously people who develop ptsd also present a higher risk of developing major depressive disorder mdd thus 5070 of ptsd patients will live with a diagnostic of mdd which in terms of prognosis means poor response to treatment and worse symptomatology despite the clinical relevance of this comorbidity it remains unknown if there are shared molecular mechanisms impairments in fear memory and learning were related to ptsd and mdd in association with atrophy and synaptic loss in the hippocampus hpc in turn the hpc plays a crucial role in fear memory encoding the contextual information related to the fearful stimulus thus we propose that maladaptive fear memory due to hippocampal dysfunction can also contribute to mdd explaining the high comorbidity between ptsd and mdd importantly preclinical research focus on fear memory have provided us with promising knowledge for potential ptsd therapeutics for instance the regulation of glucocorticoids in the golden hours after trauma to prevent memory consolidation the use of betaadrenergic blockers to disrupt consolidated memories or different psychotherapeutic approaches to enhanced memory extinction recently the advances with chemo and optogenetic technics have allowed the identification and functional modulation of neurons involved in encoding a specific memory engrams thereby allowing a highly refined study of memory substrates despite these advances the use of such approaches in genetic animal models for the study of psychiatric comorbidities is still poorly explored we believe that this combination can bring new insights and methodological possibilities for the field in parallel increase our understanding about the basis of ptsd and mdd can provide new therapeutical targets with direct implications for human health
refurbishment and additive manufacturing accomplished by kinetic deposition

ambitious goals of the european green deal call for new sustainable and materialefficient manufacturing technologies that can reduce energy and raw material consumption this objective can be upheld by extending the product life via optimized production methods recovering product performance through refurbishing and even improving its functions beyond design by remanufacturing these are the overarching objectives of remake that considers cold spray cs a solidstate metal powder deposition technique as the key for a new route to additive manufacturing am repair and remanufacturing thanks to its exceptional deposition efficiency high buildup rate limited energy consumption and flexibility of material choice cs is an ideal candidate for the eu circular economy action plan however currently there are multiple scientific and industrial gaps paired with poor awareness about css potential due to the lack of qualified engineers and scientists that impede the full exploitation of cs remake is planned to establish cs as a unique sustainable and scalable tool for am remanufacturing and upcycling paving the path to a green and efficient sustainable industrial development this ambitious goal will be achieved by training highly qualified doctoral candidates dcs through advanced transversal and intersectoral training the wideranging hard and soft skills the dcs will gain enable them to embark on tackling scientific and technological challenges with a practical perspective creating a network of leading european research and industrial partners all working at the cutting edge of cs will expose dcs to a holistic training with access to a wealth of expertise and a rare multidisciplinary environment remake will endow a first cohort of these essential researchers with a deep disciplinespecific knowledge that will fulfil the increasing demand of the manufacturing industry for this missing profile
towards an alternative history of the age of goethe

this project challenges our understanding of the core canonical period of german literary and philosophical historiography 17701830 by asking what concept of literature emerged in the period and why were some authors and philosophically engaged figures marginalised through processes of canonisation whilst others were not this was a transformational period in german literary and philosophy culture featuring major figures such as goethe schiller kant and fichte and these names continue to determine the narratives of the period in both fields through a series of three case studies the first on social cultures of emotion the second on gendered networks of philosophy and the third on local canons this project will examine the social and material contexts of literature and philosophy and ask how they influenced later processes of canonisation i will integrate a wide variety of methodological approaches including sociological concepts of networks imported into literary studies and methods from book history and intellectual history these will be used to interrogate the agency of individual mediators readers and publishers among others in the development of literature and philosophythe project will argue for a more nuanced understanding of what is understood by literature and philosophy in the period i will specifically argue that examining literary sociability opens up other overlooked contexts that are obscured by canonisation and the master narratives that develop subsequent to the period the fellowship will provide me with expertise in a variety of fields to expand on my background in literary studies i will develop specialisms in the history of philosophy and in gender studies and so will gain an interdisciplinary perspective on german studies it will furnish me with the publication record that will allow me to apply for permanent positions associate professorships in academia in the uk
shorttime analysis of largescale structures in unsteady flows

stateoftheart investigations of the hydrodynamic stability of flow fields of industrial significance are limited to timeinvariant or timeperiodic flows this is due to the lack of a robust and affordable methodology capable of obtaining the stability and sensitivity information of complex aperiodic and chaotic flows groundbreaking theoretical and numerical concepts are necessary to provide new insight into the dynamic behaviour of unsteady flow systems and develop models for their physically founded controlthis project aims to develop a theoreticalnumerical methodology that enables the effective study of the stability and the sensitivity of aperiodic and chaotic flow systems of industrial relevance a new computational tool will be developed to perform finitetime lyapunov exponent analysis in threedimensional compressible unsteady flows which will allow to characterize the perturbations producing chaos in a given flow system this tool will be combined with a novel computational methodology based on adjoint shadowing techniques which will enable the study of the sensitivity of aperiodic and chaotic flows to longterm averaged objectivesthe developed tools will be applied to two problems of practical interest in the aerospace industry the unsteady separated flow in a lowpressure turbine blade and the unsteady flow induced by a real wing undergoing fast variations in the pitching angle these analyses will allow to extract useful dynamical information about the most relevant coherent structures in the studied flow fields and exploit it to exercise flow control for the first problem experimental investigations will also be performed at purdue experimental turbine aerothermal laboratory to test flowcontrol concepts devised during the numerical analyses for the second problem the investigations will be performed during a placement at airbus defence and space