Dragon09/odtu_chatbot huggingface dataset:
teaching with money financial literacy in tuscan abacus manuals and merchants notebooks 12021478

financial literacy is necessary to spend our money wisely and understand how financial instruments work in an increasingly complex financial landscape today only half of the eu adult population has an adequate understanding of basic financial concepts edumoney tackles this issue from a historical perspective to offer the first systematic comprehensive and digital analysis of the skills and knowledge underpinning financial literacy during another period of increasing financial complexity the medieval commercial revolution the focus is on money itself and how this was deployed and represented in tuscan abacus manuals and merchants notebooks the pedagogical tools of the time the project analyses the period between 1202 when fibonacci completed his liber abaci and 1478 when the first printed abacus manual known as aritmetica di treviso was published by adopting an interdisciplinary approach that combines methods from economic history medieval literature and the history of economic thought with the support of the latest digital platforms for text analysis i will digitise transcribe and translate a selected corpus of abacus manuals and merchants notebooks this will allow a comparative and digital study of these sources to identify crossreferences to money that will be grouped into typological families the resulting categorisation will form the basis for an indepth analysis leading to an innovative treatment of money as a heuristic and pedagogical instrument and to a more holistic understanding of how people lived learnt and conceptualised their lives as economic actors the enhancement of financial literacy among different age groups through a series of didactic and outreach activities will empower people by endowing them with the right tools to make informed decisions to improve their economic wellbeing thus tackling social and gender inequalities for the development of a more inclusive europe
development of brainpermeable masked nanobodydrug conjugates to eliminate glioma stem cells

glioblastoma multiforme gbm is one of the most prevalent brain tumours and is currently incurable patients die from tumour recurrence after resection and chemotherapy new treatments need to overcome two great challenges reaching the tumour margins where the bloodbrain barrier bbb is intact and eradicating glioma stem cells gscs which cause tumour relapse targeting receptors overexpressed on cancer cells with antibodydrug conjugates adc has shown great promise in cancer treatment however most receptors on gscs are also present in normal stem cells thus targeting these receptors with antibodydrug conjugates may lead to severe side effects the main objective of this proposal is to develop a masked nanobodydrug conjugate with the capacity to overcome the bbb and to be activated only in the tumour to selectively target gscs nanobodies have increased capacity to penetrate tissues and biological barriers but none is yet available to target the gsc marker cd133 therefore i will generate new nanobodies against this receptor subsequently i will set up a phage display platform to develop masked nanobodies that can be selectively unmasked by tumour proteases the masked nanobody will be conjugated to a drug and then to a bbbshuttle peptide a panel of conjugates will be screened in vitro for target selectivity efficient activation and bbb transport finally the efficacy of the most promising candidates will be tested in a gbm mouse model our unique combination will generate the first bispecific nanobodydrug conjugates targeting gscs to treat gbm the concept of gsctargeting with activatable adc may change the current paradigm for the treatment of brain tumours furthermore our workflow may be applied to dramatically enhance the efficacy of other biotherapeutics with ontarget offsite doselimiting effects
unraveling the link between microbial biogeochemical cycles and mercury transformations in oxygendepleted submarine groundwater discharges

coastal aquifers are sensitive landocean transitional zones receiving nutrientrich water due mainly to fertilizing practices that may increase microbial activity and reduce oxygen o2 availability the diverse microbial communities inhabiting these systems may have a crucial role in biogeochemical cycles including metal transformations such as mercury hg yet the factors determining the microbial hg transformations in coastal aquifers is poorly understood the increasing depletion of o2 in coastal waters from submarine groundwater discharges sgds may modify the biogeochemical processes and hence modulates the hg speciation and its export to the sea to shed light on this the mimoa project aims at defining the role of nutrientenriched sgds in microbial hg cycling of coastal areas by combining microbial chemical and educative dimensions this project will rely on the synergy of my background in biogeochemical cycles and anoxic environments with extensive expertise in hg biogeochemistry and metagenomics of the host dr bravo this will be complemented by the essential expertise in biochemistry of low o2 zones and analyticenvironmental chemistry of the two secondment supervisors dr garciarobledo and dr amouroux by getting trained in bioinformatic analyses gene detection and chemistry i will explore the effects of o2 depletion from sgds on microbial hg transformations in an eutrophication context and transfer this knowledge to the general audience through science outreach and education assisted by plncton company as a placement mimoa outcomes will significantly contribute to global hg budget by revealing the importance of hg export through depleted o2 sgds having longterm consequences on marine food web contamination and improve awareness of general audience on their anthropic footprint in coastal zone boosting my career opportunities as a prominent researcher in microbial ecology and biogeochemistry after my research period in latin america
development of a global diagnostic ecosystem for detecting and monitoring emergencyprone pathogens across species and in a unified way

we aim to contribute to global diagnostics and preparedness for the next health crisis by developing in vitro diagnostic devices and methodologies for application at the pointofcare for this purpose mature as well as novel technologies and assays will be developed addressing all pandemic preparedness requirements ie with regards to assay characteristics and ability to assimilate new targets as well as platform ease of use and connectivity fulfilling manufacturing and regulatory requirements in the 36 months of the project we intend to develop and deliver two ivdr certified devices and six molecular assays for emerging pathogens detection at the pointofcare we will build on a recent commercial success during the covid19 pandemic the pebble platform and an innovative pocketsize device to be developed within the project both providing capability for connectivity and surveillance for the rnatargets detection we will employ a recently developed amplification method damp demonstrated to have a high specificity in crude samples three broad assays will be developed for screening of viruses belonging in one of the families of corona influenza or arboviruses and three specific ones for dengue zika and west nile viruses all according to ivdrrecommendations importantly the above six assays will be tested using samples from humans animals and during fieldmonitoring of mosquito populations providing a solution for the one health initiative for the development of accessible diagnostic tools the unihealth consortium consist of expert researchers technologists doctors social scientists regulators innovators and biomedical device providers within the areas of diagnostics and pandemics the high degree of unihealths innovation and the codevelopment of solutions with global partners and endusers will expand the visibly and uptake of the project results to a global level leading to a high preparedness and an economic and social success
freespace optical communications for aerialsatellite networks

with currently 3 billion people lacking access to broadband internet worldwide european operators are struggling to fill the white areas with insufficient or nonexistent connectivity in light of the early promises of 6g wireless networks it is tempting to consider nonterrestrial networks as complementary to the groundbased radio and fiber infrastructure however radio frequencybased satellite systems are nearing their capacity limits and cannot be scaled further freespace optical technology is a natural alternative to deliver greater capacity and to better address data security needs by leveraging quantum communications the first optical intersatellite links are being deployed in commercial networks at relatively low data rate 10 gbps however once the most important remaining research challenges are resolved they could rapidly expand and serve as a catalyst for the development of a new communication backbone in the sky consisting of aerial and space optical nodes at different altitudes the overarching aim of the focal project is to train a new generation of highly qualified doctoral candidates in developing innovative aerial and space optical wireless technologies that will provide future telecommunication networks with ubiquitous connectivity resilience and quantumproof security in addition to contributing to the fundamental understanding and technical knowhow of such networks through cosupervised individual research projects focal will train talented and innovative researchers with multidisciplinary expertise and skills that are desirable in this european industrial sector this will be achieved through a combination of theoretical and handson research training provided by a unique consortium of 16 academic and 10 industrial partners from 8 countries resulting in collaborative research including cosupervision and secondments as well as transferable training skills which is necessary for prosperous careers in this prominent ri area
novel fuelflexible ultralow emissions combustion systems for sustainable aviation

improving local air quality at airports while at the same time decarbonising aviation can be achieved by switching to sustainable aviation fuels safs and hydrogen h2 as confirmed by recent engine development programs however both these fuels require significant developments in the gasturbine combustor because present technologies not only to further reduce nox and pm emissions as expected by longterm standards and objectives but also are not normally suitable for 100 direct combustion of hydrogen in this project revolutionary combustor architectures will be studied extending the preliminary results of previous clean sky 2 innovative nox reduction technologies projects in terms of scientific scope and trl in particular this project will advance i the lean azimuthal flame leafinnox a novel combustion system based on flameless oxidation ii the compact helically arranged combustor chairlift a new system which uses interacting lean lifted flames and iii plasma and electric manipulation of the spray and of the flame stabilisation mechanism the fuel flexibility offered by these novel concepts is key to allow for saf and h2 operations this unique feature will be exploited to give novel dualfuel lto cycle strategies and ultralow nox ultralow soot single or dualfuel use experiments on available dedicated rigs and numerical work will be performed to provide knowledge at the fundamental and practical level that will allow trl3 and higher developments at the end of the project the project will include new cfd loworder and ai models and novel stabilisation techniques ripe for commercial exploitation
seeing stuff perceiving materials and their properties

different materials such as silk soil steel and soap exhibit an astonishing variety of physical properties appearances and behaviours the material properties of objects and substances are central to practically every task we perform from selecting and preparing food to detecting slippery ground to using tools effectively without touching a surface we usually enjoy a vivid impression of what it would feel like through the sense of sight yet how we do so remains mysterious decades of research has focussed on the visual recognition of objects faces and scenes by comparison how we see think about and interact with stuff has been relatively neglected stuff addresses this major gap in our understanding material perception poses unique and fascinating challenges the image of a surface is a complex and ambiguous combination of lighting shape and material properties how does the visual system disentangle these intermingled physical factors deformable materials like liquids and textiles move and change shape in complex yet lawful ways how do we infer intrinsic properties like viscosity compliance and elasticity from such everchanging stimuli and how do we reason about and predict their future behaviours as they interact with their surroundings how do we adapt our own interactions with objects to take into consideration their hardness density friction and other physical characteristics allowing us to pluck a raspberry without crushing it or pick up wet soap without it slipping through our fingersstuff takes a radically interdisciplinary approach to these questions in five tightly interconnected workpackages bringing together stateoftheart methods from experimental psychology and behavioural neuroscience computer graphics and computational image analysis machine learning and even art we draw on real and simulated materials to uncover how we perceive reason about predict and interact with materials and their properties
dietwise systemic solutions to enhance healthy and sustainable food provision and cooking at home

the dietwise advances the stateoftheart by proposing systemic changes a focus on inclusion and open social innovations with the aim of developing solutions that streamline existing tools and applications to foster healthy and sustainable food provision and to make cooking eating and treating of food at home the most attractive choice for all stakeholders using disruptive new approaches and voluntary market selfregulation our activities will help to dampen nutritional noise gradually and organically merge cultural and commercial practices with a healthier and sustainable food consumption pattern next we will empower citizens with novel citizen sciencebased solutions that will shift the role citizens play away from passive actors influenced by the food environment to citizens as active participants influencing their decisions and helping to create better digital food environments the project will generate multiple novel insights to empower citizens to make healthy and sustainable choices and original empirical evidence through big data analysis largescale surveys qualitative research and microlevel experiments from a methodological point of view we will harness novel state of the art methods such as using artificial intelligence ai algorithms with deep learning techniques to analyze big online data finally we will integrate scientific and empirical findings into social innovations powered by ai and develop useroriented tools to support citizens as a result our methodological and empirical advancements will provide a deeper understanding of how various external systemlevel environmental factors shape attitudes and beliefs towards healthy and sustainable food provision and cooking how to motivate consumers to follow nutrition guidelines how to include the ones who are in greatest need and how to help citizens shape digital food environments
fostering capacity building for civic resilience and participation dialogic communication ethics and accountability

digital communication enormously expands the number of ways people can interact and engage but also challenges european societies by spread of conflict instigation hate speech and increasing amount of disinformation the many initiators of destructive communication acts are various actors with diverse interests who are not bound by either professional or ethical rules or obligations to distribute truthful information or stand for its reliability the existing framework of public communication does not empower citizens to influence the ways the media institutions and actors operate in european democraciesdiacomet contributes to the advancement of ethical and accountable communication by fostering capacity building for civic resilience against information distortions and promoting civic accountability therefore diacomet aims to generate a concept of dialogic communication ethics dce which would provide a framework for an inclusive model of accountability mechanisms that combine media accountability the level of organisations with civic accountability the level of citizens and is guided by a civic code of good communication conduct cgc a new type of code of communication ethicsthe diacomet proposal explicitly addresses the aims of the horizon europe culture creativity and inclusive society work programme the topic the call and the european democracy action plan through1 analysis of the role of dialogic communication in existing ethics codes and guidelines and formulation of the cgc2 a novel concept of inclusive civic accountability bodies and a tested accountability mechanism3 an interactive dilemma game and a forum for learning and discussiondiacomet proposes to establish a european network of civic accountability bodies for supporting individuals groups and organizations to implement the cgc and to assist in managing ethical issues emerging in public communication
a landscape approach to cultural heritage management in the context of climate change

this proposal addresses cultural heritage conservation and management in the context of climate change it goes beyond the traditional differentiation between tangible and intangible heritage and addresses the city as a living heritage accordingly it seeks to develop a landscape peoplecentered methodological framework that acknowledges the active role of communities in coproducing local knowledge the proposed framework integrates different perspectives from different disciplines noting the scientific social and humanities approaches along with cultural and natural heritage perspectives as a result it is structured around several axes to address physical settings landscape perceptions cultural values digital heritage practices and vulnerability of cultural heritage to climate change to address the complex nature of cultural heritage the proposed method incorporates social media metadata and traditional data sources and integrates qualitative quantitative geographical and visual analysis along with machine learning techniques by doing so it seeks to map how different stakeholder groups value heritage in the context of climate change and assess the vulnerability of heritage and its associated values to climate change the novel aspect of this proposal is the use of digital technologies to engage local communities in heritage values assessment and heritage management recommendations to foster a sense of communal ownership in the local heritage landscape from the grassroots level the innovation of this project lies in linking physical vulnerability and risk management concepts with a more general and multidimensional resilience approach focused on the singularities of cultural heritage resilience results are expected to draw recommendations for integrating policies and practices of heritage management sustainable urban development and climate governance
track and forecast changes in marine fish population stability over time and across space

marine ecosystems provide key functions and services including biodiversity and food resources disturbances such as climate change and overfishing are seriously threatening the future provision of these services and leading to collapse of marine populations to track and forecast marine ecosystem stability has emerged as a new paradigm to understand the capacity of an ecosystem to persist a qualitatively similar state in the face of disturbances however three challenges prevent the advances in this research field most established stability measures assume stable equilibrium and constant magnitude of disturbances while marine ecosystems are influenced by multiple disturbances simultaneously with the magnitude of disturbances changing with time in addition even though population stability varies with space most of existing work examined marine ecosystem stability at the regional scale of fishing grounds due to limitations in data and methodology moreover age group interactions fundamentally affect population dynamics yet have been overlooked when quantifying population stability in line with those reflections this proposed research intends to develop a novel research framework to track and forecast marine population stability encompassing temporal and spatial dimensions of three key fish species of the north sea wp1 and to identify drivers of population stability across space wp2 empirical dynamic modelling will be used to track and forecast the evolution of population stability over time and across space based on age group interactions of the population producing yearly population stability maps from 1977 to 2022 and forecast maps from 2023 onward these results will be transformed into webbased interactive map and manual wp3 for fisheries managers and researchers to identify the most vulnerable locations in the fishing grounds and to decide fishing quota with the overall goal of preserving stability in marine ecosystems
awareness and resilience through european multi sensor system

public awareness to environmental risk is key for building resilient societies artemis will develop a smart sensor system monitoring radon temperature acidity and other observables in groundwater in real time the groundbreaking sensor design will assure affordability resilience and low power consumption optimizing life cycle management the project aims to produce 100200 sensors that will be deployed in sensitive sites in collaboration with municipalities changes in radon concentration have the potential to serve as precursor for earthquakes and volcano eruptions to advance our knowledge in this field we propose the development of a cheap sensor system that can be employed on a large scale in earthquake prone areas of europe the real time collected data is used to build machine learning ml models for the analysis the collected and ai processed data will generate a real time map of hydrological and geochemical changes that is shared to the scientific community and public bodies engaged in the project a pilot project engaging citizens of the participating municipalities is part of the dissemination and exploitation activities we expect artemis to clarify the longstanding issue of earthquake predictions by means of geochemical precursors like changes in radon concentration the system is designed for scalability dissemination and exploitation activities are tailormade to ensure support and expansion of artemis after the projects completion radon content in water causes health issues and artemis offers a novel way to monitor both content of radon as well as changes in real time that may indicate changes in flow pattern hence artemis is facilitating multipurpose use of the sensor system the project will result in a shift of paradigm for environmental monitoring and natural hazards and in this fashion render europe a leading role in environmental monitoring