Dragon09/odtu_chatbot huggingface dataset:
ecotoxicogical assessment of banned and novel pfas as individuals or in mixture

the group of per and polyfluoroalkyl substances pfas are thermally and chemically stable with strong hydrophobic and lipophobic properties making them highly suitable for many applications however they are part of the emerging chemicals identified to be persistent and bioaccumulative they are very stable nondegradable and present all around the world more than 9000 distinct individual compounds make up the pfas group with a carbon chain backbone between 4 and 14 c atoms in length and a charged functional moiety sulfonate or carboxylate the two principal representatives and studied pfas perfluorooctanoic acid pfoa and perfluorooctane sulfonate pfos are banned in many countries leading the major global manufacturers to find alternatives having shorter carbon chains c8 or with replacement chemistry with multiple etheroxygens inserted between the perfluorinated carbon backbones allowing the formation of noncovalent hydrogen bonds with a water molecule which makes them more labile to degradation however those new chemicals have been identified in various environmental matrices are now becoming global contaminants but our understanding of the pfas alternatives toxicity is lacking in aquatic organisms and in the case of emerging replacements and byproducts even not unexplored studies assessing their potential genetic developmental cellular and systemic toxicities have not yet been conducted in aquatic organisms to that purpose the ecopfas project will investigate the acute toxicity developmental toxicity genotoxicity and toxicity pathways for pfas alternatives in three freshwater species ecopfas project will build on the expertise of the researchers involved together with the acquired data to provide a basis for a better understanding of the influence of the effects on individual and population fitness to support a broader integration of these data into risk assessment frameworks
application of gasphase atmospheric pressure ionization sources to assess the widescope determination of pfas in environmental and biological samples

per and polyfluoroalkyl substances pfas are undoubtedly a worldwide threat due to their high persistence and widespread distribution in the environment bioaccumulation capacity and toxic effect on human health through chronic exposure despite a lot of research has been conducted to find solutions for the pfas problem critical gaps such as the lack of transparency of manufacturers the analytical issues to determine pfas and the difficulties to find the best way to regulate them and minimize the environmental and human exposure remain the major challenges thus it is important to develop an analytical platform not only to increase the reliability of pfas determination but also to provide analytical tools to policymakers for a better application of inforce and future regulations ms4pfas aims to propose highthroughput cuttingedge methodologies based on mass spectrometry ms to sort out the complexity of the analysis of the vast families of pfas the use of novel andor dual atmospheric pressure ionization techniques for nontargeted liquid chromatographyhighresolution mass spectrometry approaches will increase the range of ionizable substances and will lead to unprecedented advantages to achieve a widescope determination of ionic and neutral pfas in biological and environmental matrices the most promising analytical platform will be chosen to propose highly confident identification strategies that will be integrated into a powerful nontargeted workflow to address the determination of known and emerging pfas the workflow will be validated and used to extend the knowledge in relevant societal applications such as the monitoring of pfas in drinking water updating the development of more efficient water treatment technologies and in human biofluids breast milk plasma urine upgrading running epidemiological studies on the links of chronic exposure to pfas and observed health impairments
call to prayer romani people and the islamic mission

the project call to prayer explores muslim missionary activity dawah in romanimajority neighborhoods in amman jordan until relatively recently insulated communities without significant participation in public religious life the various romani groups in jordan are increasingly inculcated in praying in mosques attending friday sermons and only now attaining literacy are for the first time being introduced to islams textual tradition long distinguished from wider jordanian society by an identifiable heritage that includes peculiar dress castelike occupations unconventional dowry and marriage rites and use of nonarabic languages the entry of romani peoples into organized religious life poses a novel situation in the social trajectory of these groups how do missionaries who recruit from already muslim but ostensibly not actively religious populations find success among romani groups this is particularly poignant for romani peoples because dawah has a tendency to minimize national ethnic and linguistic difference fostering instead a panislamic identity that transcends particularities as such i will use the fellowship period to complete several writing projects including a book manuscript based on ethnographic fieldwork conducted as a national endowment for the humanities neh postdoctoral fellow at the american center of research in jordan for ten months during the 20222023 academic year as well as during earlier visits my work is a closeup ethnographic look that engages philosophical questions about how dawah helps shape workingclass religious sensibilities in lieu of an orthodoxy that has remade muslim ethics in recent decades the capacity of religious doctrine to accommodate alterity and the relationship between folk religion and orthodoxy in the contemporary world
biomimetic membranes for organ support

acute respiratory distress syndrome ards is currently seen in huge numbers of patients worldwide due to the covid19 pandemicbut also before that respiratory diseases were the third largest cause of death in the eu current therapy for respiratory failureincludes mechanical ventilation and extracorporeal membrane oxygenation ecmo both associated with high morbidity andmortality in ecmo devices the functionality of the lungs tissue membranes that are responsible for gas exchange during breathing isusually taken over by bundles of synthetic cylindrical hollow fiber membranes geometries and transport characteristics of standardhollow fiber membranes are not suitable for rebuilding the structurally complex and dynamic contracting microstructure of themammalian lung and consequently artificial devices to assistreplace respiration still face major limitations in size flow characteristicsand hemocompatibility that impede the development of efficient intracorporeal devices in biomembros we want to follow agroundbreaking new biomimetic approach and replicate main characteristics of the most effective respiration found in vertebratesmainly birds and fish in order to develop membrane structures that will serve as key elements for a novel generation of artificialrespiration devices to reach this goal we will a optimize geometry of the membrane structure by mimicking microstructure of thegills of fish to increase outer surface per membrane area mimicking globular shape of the gas transporting inner lumen andinterconnected arrangement of membrane fibers of avian respiration b design and control flow characteristics and boundary layerapplying piv experimental flow investigations and structural design optimization c design and synthesize bisoft segmentpolyurethane membranes with increased hemocompatibility and gas permeability with phase inversion and d verify and benchmarkthe boosted mass transfer capabilities by invitro blood tests
enabling clinical research in emergency and acute care medicine through automated data extraction

to date the possibility of doing research on qualityofcare assessment in emergency medicine has clashed against sustainability problems the vast number of patients visiting an ed and the staff shortage that often afflicts these departments make ad hoc data collections unattainablethe only way to fill the gap between the need for clinical research and the availability of robust data is to directly extract such data from the eds electronic health records ehrs avoiding dedicated data collection achieving this goal would enable distributed clinical research which is now too much restricted to academic centres and allow to leverage of clinical information to address a multitude of research questionsnonetheless obtaining consistent data from ehrs is a complex task while a small part of the data registered in ehrs is structured such as lab test results and vital parameters most of the useful information on patients conditions is variably contained in free text eg presence of signs and symptoms suspected and confirmed diagnosis anamnesis etc moreover as a proactive followup of ed patients is unfeasible relying on the existing data sources is also necessary to measure the outcome of the patients at the most appropriate time interval for the research question of interestthis proposal has three main aims1 to develop new technical solutions to extract reliable clinical information from structured and unstructured data contained in different electronic patient files2 to fairify ie making data findable accessible interoperable and reusable the established databases for clinicians researchers health policymakers and citizens while respecting the european and national legislations3 to pilot the exploitation of the established databases in two relevant use cases i assessment of ed propensity to hospitalise a patient and ii development of a dashboard to be used by citizens and policymakers to improve the quality of care in ed
exploring digital participation with children to coproduce knowledge for active neighbourhoods using softgis methodology in delhi india

digipack aims to demonstrate the potential of innovative digital participatory tools for mapping and comparing active mobilitybehaviour and localized experiences with children across their gender age socioeconomic status and settlement typologies withinthe global south context the key research objectives are 1 to adapt and contextualize softgis methodology for enabling digitalparticipatory planning with children in india 2 to map and compare childrens active mobility behaviour mode of transportaccompaniment homeschool route and environmental experiences location of meaningful places frequency of visits perceivedenvironmental fears and likability index across four dimensions of age gender socioeconomic status and urban settlementtypologies using softgis and 3 to evaluate the potential of softgis methodology to integrate within indias urban planning policyframework adopting a comparative case study approach the softgis data will be collected from children aged 1017 years frommiddle and lowermiddleincome families across three distinct neighbourhood settlement typologies of delhi and analysed usingquantitative statistical techniques actornetworktheory will be employed for evaluating the role of softgis in the participatoryplanning policy framework the project results including contextualized digital methodology and new knowledge on how agegender socioeconomic status and urban settlement influence childrens active mobility behaviour will open up new researchavenues and have the potential to revolutionize participatory urban planning with children in india and the global south morebroadly the 2year project will be hosted by the department of built environment aalto university whose leading expertise inpioneering the softgis methodology since 2005 will assist me in acquiring new technical skills and building strong europeannetworks to pursue a career in academia within the global south context
development of a highthroughput microplate based device to analyse the patient derived tumour microenvironment

cancer and tumours are exceptionally heterogeneous in tissue and cellular composition clinical stage and mutational status additionally the presence of multiple cancers or metastatic tumours in patients leads to complicated drug regimens resulting in high offtarget toxicity unexpected drug resistance and difficulties in understanding the therapeutic effectsdespite a global investment in oncological drug development reaching 5 bn usd less than 5 of all oncological drugs in the pipeline enter the therapy toolbox given the huge burden that cancer poses at all levels in society leading cause of mortality worldwide expected to reach 20 m deaths by 2050 technologies that enable pharmaceutical companies to increase the efficiency of drug development may alleviate the threat imposed to the more than 50 m people currently living with cancersuch technologies include preclinical models that represent the tumour microenvironment and reveal the effect of drug candidates in laboratory tumour replicas to provide clinically relevant information such models must be patient specific and represent simultaneously the specificity of the target tissue and the cell heterogeneity of the tumour microenvironment in addition to be industrially relevant they must be implementable reproducible and high throughput commercially available solutions do not meet these requirements3dtumour provides a proprietary technology to produce multiple 3d bioprinted replicas of patientderived tumour models that faithfully represent the therapeutic target for a drug candidate 3dtumour aims at increasing the drug development success rate by transferring to industry this pharmaceutical testing platform the successful outcome of this poc will provide clinicians with a tool to test the efficacy of drugs ex vivo accelerating the onset of efficient treatments and reducing offtarget toxicity and unexpected drug resistance by applying a personalizedmedicine approach
sustainable development goals enhanced monitoring through the family of copernicus services

the un 2030 agenda for sustainable development is a data driven agenda and the use of earth observation eo can make the sdg indicators monitoring and reporting viable technically and financially and comparable across countriessdgseyes aims at boosting the european capacity for monitoring the sdgs based on copernicus building a portfolio of decisionmaking tools to monitor those sdg indicators related to the environment from an intersectoral perspective aligning with the eu green deal priorities and challengessdgseyes will establish an integrated scientific technological and user engagement framework overcoming the knowledge and technical barriers that prevent the exploitation combination and crossfeeding of data and tools from the copernicuss six core services its spacebased and insitu components and other platforms and portalssdgseyes considers three interconnected sdgs on climate sdg13 ocean sdg14 and land sdg15 to demonstrate through four pilots the copernicus potential for monitoring six indicators making part of the eu and national assessments ghg emissions temperature deviation ocean acidification marine eutrophication forest cover change and soil erosion although focusing on the biosphere these indicators are linked to other sdgs on socioeconomic and geopolitical factors eg human health resources security poverty conflicts displacements thus an additional crossgoals indicator and pilot will focus on vulnerable communities under cumulative climate extreme hazardssdgseyes seeks to combine the scienceinformed topdown approach with a stakeholderdriven bottomup approach to transfer scientific outcomes into easytounderstand and easytouse actionable information in the context of sdg indicators assessment decisionmaking tools delivered by pilots will be codesigned with users to offer opportunities to regularly assess and refresh methodologies they adopt for monitoring and reporting
unleashing ai potential to foster space accessibility and novel earth observation services creation

satellites have become one of most prominent technologies for earth observation progressively attracting large investments from both the private and public sector and potentially becoming the next lifechanging trend in world economics resulting from technological advancements and gradual reduction in manufacturing and inorbit deployment costs data captured drastically increased along revealing significant impairments in current data management infrastructure to maximise associated added value with the purpose of achieving a more efficient data management to further approach novel eo applications requiring continuous data flow between capturing and processing deep neural networks dnns deployment at the edge has been investigated as valid approach to allow autonomous and reliable data payload and latency reduction while keeping high added value from data captured however deployment of accurate dnns models present several limitations with the major ones being high computational power and cumbersome architectures in this project proposal edge spaice develops an extremely efficient approach to resize complex dnns while ensuring compatibility requirements for onboard satellites hardware are met with this scope edge spaice will further target a challenging demonstration of edgeai potential by design and deployment of a dnn for marine plastic litter remote monitoring from inorbit representative satellite paving the way towards next generation eo and moving european leadership in the global space market
space application gan transistor

the sagan proposal addresses a crucial element in future satellite platforms and payloads spacecraft electrical power systems eps are a key element that enable space missions without an efficient eps many of the capabilities that we take today for granted such as highspeed communications gnss and science payloads would not be possiblepower transistors are key elements of the electrical units that form the eps and other systems since they allow the most efficient in terms of power and mass electrical power processing topologies during the last decade several technological advancements have enabled a new type of transistors based on gallium nitride over silicon gan transistors allow a reduction in mass of the equipment that uses them and a reduction in power consumptioncurrently europe does not have the capabilities to produce gan transistors for space unless relying on external countries for most of the supply chain which is something that cannot be taken for granted the objective of the sagan proposal is to overcome this situation by establishing a nondependent supply chain design manufacturing processing and qualification testing for gan transistors that are suitable for space applications the transistors will be tested to assess radiation effects thermal dynamics structural behaviour reliaability to achieve it a strong consortium has been established it is composed by organisations that have the knowleadge and the facilities to fulfil the objective the consortium is composed of a company devoted to space level gan transistors and integrated circuit design semi zabala a research foundry imec a company that processes wafers to the standards required by the technology disco hitec and a satellite equipment manufacturer with component packaging capabilities sener the consortium also counts with the role of gan transistor end user which is played by sener as spacecraft equipment manufacturer
biomat4cast petru poni institute of macromolecular chemistry multiscale in silico laboratory for complex and smart biomaterials

the strategic objective of the biomat4cast project is to implement a structural change within in the scientific management paradigm of petru poni institute of macromolecular chemistry icmpp iasi romania by setting up a competitive research group in the field of computational chemistry under the supervision of an outstanding researcher manager in the field of computational chemistry prof aatto laaksonen arrhenius laboratory stockholm university swedenthe objectives of the biomat4cast project addresses directly to the targets of the horizon europe program to support research organisations to attract outstanding researcher andor innovator in the chosen scientific domain thus to achieve excellence on a sustainable basis the biomat4cast project results matches the destination 2 attracting and mobilising the best talents of the horizon europe programthe biomat4cast project will raise the rtd standards of icmpp as the first ne romanian region research center having a critical mass enabling it to spread excellence in the specific field of computational chemistry able to link the romanian computational school to the world association of theoretical and computational chemists through ongoing cooperation partnership and shearing of knowhowtechnical expertise the ambition of biomat4cast project is to become after the project ends an example of good practice and a model of knowledge sharing
realtime flow and flux measurements for combating groundwater supply and pollution

iflux mission is to make groundwater visible we have raised 136 million in equity 1185k through straight convertible loans with revenues from our developed paid projects we brought our first product into the market a passive flux sampler to measure monitor 127 types of pollutants in the groundwater and determine their impact today our sampling technology has been used by 100 customers across the eu and generated revenues 750k these customers include companies such as dow total erm arcadis a scalable realtime groundwater flow flux sensing probe is our urgent development pipeline because monitoring groundwater dynamics is complex and requires highly accurate realtime data to create a better understanding of aquifer behavior over time and spatially with our sensing probe we will be the next generation water monitoring solution by visualizing and integrating the dynamics of groundwater and its pollution
a million qubit quantum computer highly scalable solid state quantum computing platform with native optical networking

highly scalable solid state quantum computing platform with native optical networking a million qubits quantum computerquantum transistors is a quantum chip and computer company which aims to be the next nvidia of the quantum computingworld we design and aim to manufacture semifabless an integrated quantum processor unit our initial device will use cooling to only 77k thus avoiding the need for a hugesize and highenergy subkelvin refrigeration system our solution will enable a server form factor and substantial savings in energy and space in the long term we aim to get our technology to room temperature and allow for a far wider adoption even to consumer devicesour highly scalable solution can scale from x10s of thousands of qubits to millions of qubits and beyond we rely on massscalefabrication and enable a fraction of the cost small size and high operating temperature