Dragon09/odtu_chatbot huggingface dataset:
titaniumorganic framework membranes for co2 capture

the continued growth in emissions of greenhouse gases in the atmosphere is a pressing issue for our society the urgent need for strategies to reduce greenhouses gas concentrations has aroused international action from governments carbon capture and storage technologies ccs have been considered a key solution to reverse the current co2 trend because they can mitigate or at least delay the alarming greenhouses effects however the most effective solution for postcombustion co2 remains still the chemisorption in aqueous solutions of alkanolamines despite limitations as low selectivity corrosiveness and high energy requirement for operation and maintenance membranes are arguably an attractive technology for co2 removal from mixed humid gases as it is a relatively simple technology that can be easily replaced and requires minimum investment and operation costs in this regard mixedmatrix membranes incorporating metalorganic frameworks mofs as crystalline components are an excellent alternative to overcome two of the major limitations of polymerbased membranes swelling and low selectivity towards co2 among the families of titaniumorganic frameworks developed in the erc stg grant chemfsmof 714122 one of our patented materials muv10 represents a significant improvement or meets the specifications of benchmark materials in terms of key properties relevant to co2 capture in wet conditions as gravimetric uptake adsorbate selectivity energy efficient sorbent regeneration and recyclability in humid environments with porecapture we intend now to explore the commercial potential of this material across three main goals that will include 1 optimizing its production at multigram scale 2 fabricating a new generation of membranes for energy efficient co2 capture that will be tested in operational environments and 3 defining an optimal business model strategy that will include validating our knowhow with licensors of ccs technologies
optical fronthaul communications links based on reflective semiconductor optical amplifier transmitters for next generation radiooverfiber 56g mobile systems

colourless optical transmitters provide compact and economic designs to develop optical fronthaul network technologies for future mobile and general wireless networks semiconductor optical amplifiers soas have great potential in realising efficient colourless transmitters as they can simultaneously provide amplification and modulation capabilities this project will exploit reflective soa rsoa based colourless transmitter designs to integrate efficient and costeffective radio over fiber rof systems the rsoas feasibility to integrate developed technologies like wavelength division multiplexingpassive optical network wdmpon for next generation access networks will be addressed the project will carry out rsoasystem modelling and experimental evaluation of several designs focusing on multi gigabitper second data transmission through the use of advanced modulation formats in particular as 16level pulse amplitude modulation 16pam the designed systems will employ and compare two seeding schemes to optically feed rsoa external light seeding with coherent light source and broadband seeding transmission system performance will be evaluated particularly in terms of received signal constellation properties and bit error rate ber the impact of rsoas in such systems will be studied in detail to decide the optimal rsoa operating parameters such as its bias and modulation currents and input optical power the work will address challenges that impact soa performance in wdmpons such as the influence of soa nonlinearities and noise the proposed research will aid the design of novel rof systems that can support future 56g infrastructure the project will be implemented in a leading multidisciplinary research group and the researcher will bring modelling and advanced experimental handson experiences that will facilitate research in the group
neuroregenerative peptide treatment for multiple sclerosis

regenera ms will assess the technical and commercial feasibility of a novel peptide as a superior treatment for multiple sclerosis ms successful commercialization of our peptide could reduce the socioeconomic burden of ms provide an earlytherapy option to delay disease progression and thus extend and improve patients lives with potential effectiveness in related neurodegenerative diseases ms is a chronic inflammatory autoimmune and neurological disease without a cure affecting the lives of 12m europeans and causing significant economic costs to patients and society currently there is no cure for ms approved diseasemodifying treatments such as ifn1 glatiramer acetate and alemtuzumab are clinically effective but come with high costs significant sideeffects and intrusive administration thus a medical unmet need remains for novel ms therapies that can halt progression promote myelin repair and limit complications to improve on the current therapeutic regimen we propose a nextgeneration neurotrophic factor ntf therapy that has curative potential by halting ms progression and regenerating demyelinated tissue my group has discovered a novel peptide with neurotrophic properties and which in contrast to classical ntfs i has neurorestorative effects and can enhance remyelination ii penetrates the bloodbrain barrier bbb iii can be subcutaneously administered and iv can be inexpensively produced in regenera ms we will evaluate the pharmacokinetic properties and efficacy of a novel therapeutic peptide in organotypic brain cultures human induced oligodendrocytelike pluripotent stem cellderived cells and in ms animal models subsequently we will verify the ip position and strategy perform an indepth market and competitor analysis and finally consolidate these findings into a business case to establish the best path to commercialization
distributed data modelling and federated digital twinning for lifecycle datadriven sustainable operation and management of buildings and districts

as the built environment continues to face challenges such as climate change energy consumption and social inequality there is a growing need for adopting sustainable building practices beyond energy considerations encompassing environmental social and economic dimensions across the entire lifecycle of buildingsin view of these challenges wilson proposes a groundbreaking approach leveraging semantic data repositories cognitive digital twins and decentralized data management to transform building and buildings portfolio management the project aims to enhance sustainability by harnessing cuttingedge technologies and innovative management practices to achieve it wilson main development is focused on a decentralized data mesh architecture that is agnostic to and interoperable with proprietary bms and digital twin systemskey objectives include improving building operations evaluating environmental impact and enhancing building diagnosis and monitoring personalized data hubs pdhs will connect and integrate all wilson solutions adhering to international data space ids principles these solutions will be complemented by an investment tool to support decisionmaking on renovation and res investmentsto maximize its impact across the eu wilson will validate and demonstrate its solutions in four largescale pilots across different european countries the consortium comprises 16 partners 50 smes and industry with diverse expertise including research institutions technological providers an international data association and finance smes overall the project aims to upgrade 200000 m2 of buildings reducing maintenance costs by up to 35 in the longterm wilson seeks to ensure europes global competitiveness data sovereignty and achievement of eu energy and environmental goals by 2050 resulting in a highly energyefficient and decarbonized building stock
structural and biophysical characterisation of insulin receptor and glutamate receptors ampar and nmdar in complex with sorcs coreceptors 1 and 2

type ii diabetes t2d alzheimers disease ad and parkinsons disease pd are common agerelated diseases which have reached endemic levels and become a burden for the global health lifestyle and environment are risk factors but cannot explain all cases genes also predispose for these diseases common for t2d ad and pd is abnormal cell function associated with dysfunction of insulin receptor ampa receptor or nmda receptor the vacuolar protein sorting 10 protein vps10p family contain five neural type 1 transmembrane sorting receptors sortilin sorla sorcs1 sorcs2 and sorcs3 that play a central role in control of neuronal viability and function by sorting crucial proteins sorcs1 and sorcs2 interact with and sort ir ampar and nmdar and genetic deficiencies for sorcs1 and 2 are associated with accelerated onset of pathology thus implicating these receptors as critical regulators for normal cell function however the molecular mechanisms of sorcs1 and sorcs2 mediated sorting of target receptors are not known and with this proposal i want to determine structures and investigate interactions of sorcs1ir sorcs1ampar and sorcs2nmdar complexes determining the structures of transmembrane sorcs1ir sorcs1ampar and sorcs2nmdar complexes by cryogenic electron microscopy cryoem we will reveal molecular details about the interaction such as the role of interacting elements at cytoplasmic tails transmembrane helices and exodomains and how they define specificity sorcs1 vs sorcs2 function and regulation the proposed project can define new positions and in translational research that aims for drug discovery for t2d ad and pd
managing donkey and horse resources following the collapse of the roman empire in france

alongside horses donkeys represent a member of the horse family wellknown for their economic social and ritual importance in protohistoric france traditionally horses and donkeys have provided humankind with complementary services not only enhancing our capacity to travel well above our own speed but also to transport heavy loads across rugged landscapes and to improve farming yields however the entire history of horse and donkey management remains difficult to reconstruct based on textual iconographic and archaeological evidence the sequence of ancient dna molecules preserved in archaeological remains has recently provided a new complementary historical source considerably advancing our capacity to track the numbers types and movements of domestic animals in the past and therefore to unravel changing herding management practices through time postequus will apply stateoftheart approaches in ancient horse genomics and develop an innovative genotyping solution for the domestic donkey to generate an unprecedented corpus of genomic data to assess the phenotypic and genetic diversity of both species in the past history of france by genetically profiling horses and donkeys from the collapse of the roman empire 6th century ce to the 18th century ce postequus will reveal the whole breadth of equine management strategies and their evolution in the face of major societal crises and invasions
strengthening environmental surveillance to advance public health action

the odin project aims at strengthening capacity for genomics and bioinformatics database management skills for generating maintaining and querying large genomic epidemiology data sets in subsaharan countries to reach this goal odin will develop a genomic surveillance system relying on environmental monitoring of major communicable disease agents and antimicrobial resistance in community wastewater and other environmental samples containing human and animal excreta in a socially and ethically acceptable anonymous manner environmental surveillance systems follow the trends in prevalence and may detect the outbreaks of communicable diseases in human communities and to convey this information to key stakeholders for the efficient implementation of datadriven public health policies a strong and innovative aspect of this project is the combination of various semiautomatic bioinformatics tools for the processing and analysis of genomic epidemiology data disseminated through a visual dashboard providing means for timely public health interventions the odin project implements the three pillars of the one health framework human health animal health and the environment which is crucial for communicable disease epidemiology in resource and infrastructurepoor regions together with extensive training activities odin implementation will result in a substantial strengthening in the capacity and infrastructure in subsaharan countries for genomic epidemiology networking and capacity building are an integrated part of the project activities and will comprise communication activities with stakeholders and training of msc and phd students by its multidisciplinary team odin will contribute to setting up a sustainable model for how environmental surveillance systems can support the control of povertyrelated and emergingreemerging infections in subsaharan africa and promote the public health interventions targeting safe water supply and sanitation
dac freights intelligent transformation

digital automatic coupling dac as a cornerstone innovation promises a smoother transition to a fully digital rail freight system across europe dac is not just a technological leap its a key in meeting the green deals sustainability targets and the ambitious aims of the digitalization package 2022 the deployment of dac is gaining momentum through the european dac delivery programme eddp which is an integral part of europes rails eurail extensive multiannual work agenda this initiative is especially underscored in europes rail flagship project known as fp5 trans4mr in the workstream of fully digitalized freight train operations fdfto dedicated to advancing and rolling out the dac technologyat the heart of this evolution is the project at hand dacfit which pledges its support to the eddp and the eurail joint undertaking dacfits collaboration is not just supportive but pivotal drawing on a network of recognized experts across technical managerial and operational spheres to provide key insights and implementation plans it plays a critical role in enabling the implementation of the the eddps dac migration roadmap focusing on both quantitative numerical and qualitative technical capabilities fleet analysis retrofit engineering planning for retrofit capacity and comprehensive retrofitting implementation plansin essence dacfits role is to ensure that the transition to a digitalized automated and sustainable rail freight network is not just a vision but a reality aligning with the broader objectives of enhancing europes rail freight capabilities while adhering to overarching environmental and digital transformation goals
versatile infrared light source for advanced illumination

medical and consumer electronics markets drive an evergrowing demand for powerful compact high quality and costeffective femtosecond fs sources ophthalmic surgery and stent manufacturing in the medical field postprocessing of oled panels defective pixels and smartphones machining in the consumer electronic field are examples of maturing processes where ultrafast lasers ul are key enablers in the global scientific instrumentation market nonlinear multimodal optical microscopy multiphoton absorption fluorescence or coherent raman microscopy high energy photon coherent radiation via high harmonic generation processes high energy particle beam generation timeresolved dynamic charge transfer studies in materials are in increasing use in research laboratories such increasing business perspectives fuel a worldwide competition for ul manufacturersthe visual project aims to strengthen the leadership of the industrial ul manufacturing partners in the scientific medical and industrial application fields based upon a novel designtocost and innovative ul platform providing an unprecedented technical versatility this highaveragepower platform will deliver ultrashort optical pulses with pulseondemand capability at very high repetition rates 60 mhz and with extremely broad wavelength tuning ability the numerous benefits of this platform designed for multipurpose applications cases will be assessed within the framework of visual in labelfree bioimaging and medical diagnosis in onchip particle acceleration for electronbeam therapy and in advanced fiber and glass microstructuration
training the next generation of ice researchers

in 2019 the european aviation safety agency easa identified inflight icing as a priority 1 issue for large aeroplanes with the aggregated european risk classification scheme score being amongst the highest of all safety issues inflight icing can occur when an aircraft flies through clouds of supercooled droplets namely drops of liquid water with a temperature below the freezing point which freezes upon impact aircraft icing can lead to a reduction of visibility damage due to ice shedding blockage of probes and static vents reduced flight performance engine power loss etc in addition to safety concerns inservice icing events can lead to major disruption of air operation and aircraft maintenance the more frequent occurrence of severe thunderstorms due to climate change results in more inflight accidents also at cruising altitudes with more than 100 engine failures in recent years recently icingrelated issues are being observed in newer more efficient aircraft engines due to the lower temperature of operation the main goal of traces ejd is to provide highlevel training in the field of inflight icing to deliver a new generation of high achieving early stage researchers in the diverse disciplines necessary for mastering the complexity of ice accretion and its mitigation in aircraft and aeroengines this goal will be achieved by a unique combination of handson research training nonacademic placements at major eu aviation industries and courses and workshops on scientific and complementary socalled soft skills facilitated by the academicnonacademic composition of the consortium innovative ice detection and ice protection systems based on disruptive technologies will be designed by the esrs during project working group easa will provide training on certification procedure and together with major industries in the field will assess the esrs projects during a team design certify exercise
finding new target to modulate food intake

obesity is a major burden to public health as it increases the risk of several chronic diseases like diabetes cardiovascular diseases musculoskeletal disorders or some cancers energy homeostasis is centrally regulated by the hypothalamus where the arcuate nucleus arc orchestrates feeding behaviors and energy balance two neuronal populations of the arc are considered as the firstorder neurons mediating the effects of various signals such as leptin and insulin the orexigenic neuropeptide npyagoutirelated peptide agrp neurons and the anorexigenic proopiomelanocortin pomcamphetamineregulated transcript cart neurons leptin is an adipocytesecreted peptidic hormone that inhibits food intake and regulates body weight nearly in all forms of obesity circulating levels of leptin increase but fail to suppress food intake and body weight this condition has been identified as leptin resistance g proteincoupled receptors gpcrs are the largest family of membrane proteins and a notoriously successful source of drug targets however many gpcrs are understudied or even orphans meaning they have no known ligands despite our knowledge of the principal circuits regulating feeding satiety hunger and energy expenditure we have been unable to deliver effective drugs targeting these systems the failure in targeting the melanocortin pathways comes out partly from an incomplete understanding of leptin action especially leptin resistance at the central level here we propose to investigate the interplay between the signaling of orphan gpcr and leptin receptor in leptin sensitive cells of the arcuate nucleus to do so we will use conditional knockout animals and pharmacological modulators we will measure various metabolic parameters including weight and food intake with the comprehensive laboratory animal monitoring system clams we will also establish hypothalamic cell cultures in which we will address the impact of g protein signaling on leptin
sustainable interventions and healthy behaviours for adolescent primary prevention of cancer with digital tools

primary prevention of cancer through behaviour changes in adolescence a critical period in which many risk behaviours are initiated is a huge health and societal challenge in europe in alignment with this need sunrise will cocreate implement and evaluate an innovative digitallyenhanced lifeskills programme for primary prevention of cancer through sustainable health behaviour change in adolescents tailored to their socioeconomic cultural and environmental diversities sunrise will combine an established evidencebased digital solution for smoking prevention with novel intervention approaches such as peer social media campaigns advertising literacy training educational games and social robot platforms to take cancer prevention approaches for adolescents in the eu to the next level the digitallyenhanced programme and its components will be developed through cocreation with schoolsaslivinglabs methods involving multiple societal actors such as educators adolescents parents public health experts and policymakers the programme will be implemented and evaluated at large scale across 154 schools and 7500 students in urban and rural regions of 8 european countries greece switzerland slovenia spain cyprus italy belgium romania including socially disadvantaged groups such as migrants and ethnic minorities the effectiveness of both methods for achieving longterm health behaviour change as well as the implementation strategy for solution adoption and multicountry sustainability will be evaluatedthis action is part of the cancer mission cluster of projects on prevention early detection behavioural change
trends and uncertainties in mercury hg atmospheric chemistry

anthropogenic emissions of the toxic heavy metal mercury hg threaten human health and ecosystems the elemental form of emitted gaseous mercury hg0 can be transported globally in the atmosphere due to its long lifetime of 46 months but upon oxidation it forms soluble divalent mercury hgii which is rained out within days however there are many uncertainties associated with atmospheric hg chemistry leading to uncertain predictions of its fate and ecosystem impacts additionally it is unknown how hg cycling has been affected by recent global changeinduced trends in atmospheric oxidants eg ozone and halogens to address these knowledge gaps the interdisciplinary sumac project will train the experienced researcher er to integrate the latest knowledge from laboratory kinetics computational and isotope chemistry and field measurements into a global atmospheric hg model geoschem by applying statistical methods from the field of global sensitivity analysis the er will identify the key chemical reaction rates that contribute the most to the uncertainty in the atmospheric hg lifetime using bayesian inference methods the er will develop constraints from field measurements for these reaction rates establishing a new chemical mechanism for atmospheric hg models with the refined hg chemical mechanism the er will conduct historical and future simulations to evaluate temporal trends in the hg chemical lifetime and resultant impacts on hg dispersion and deposition by being the first study to quantify the influence of atmospheric chemistry on observed hg trends sumac will support the effectiveness evaluation of the minamata convention on mercury an international treaty aimed at reducing hg emissions aside from the breakthrough research outcomes sumac will strengthen the capacity of hg modelling within europe through the ers training activities knowledge transfer to host institutions openaccess model development and outreach