Dragon09/odtu_chatbot huggingface dataset:
lignin utilization in myceliumbased biocomposites from recycled wood

we have reached a point where we have to use recycled wood which is mostly contaminated to a greater extent because there is a shortage of raw wood in the eu at the same time in pulp mills we produce large amounts of lignin however use it mainly for energy purposeslignombb is bringing technology for the production of myceliumbased biocomposites mbb during which recycled wood is decontaminated secondly lignombb is using lignin which is currently mainly used for energy and is understood as a by or waste product in order to achieve better mycelial growth on the developed substrate i am the first to suggest enriching the substrate for the production of mbb with lignin expecting that the addition of lignin will result in better mechanical properties of the mbb lignombb develops materials only from recycled wood and lignin ie it does not use agricultural residues as is currently common practice and does not endanger food security at the same time it finds application for large volumes of old contaminated wood which is currently entering circulation my first objective is to develop a technology for the material use of lignin and a substitution technology of agricultural residues in mbbs with lignin and recycled wood then i will answer the questions to which extent additional lignin in mbb is consumed by fungi what are the limits of substrate enrichment by lignin in accordance with the second objective i will develop a novel mbb to be used in structural applications at different stages of the mbb cycle i will measure the voc emissions because i am hypothesizing that the production process of mbb can act as bioremediation and decreases voc emissions from materialslignombb will be implemented at boku in bioresources technologies tulln group where the emphasis is placed on cradletocradle design and brings to this group methods of recycled wood decontamination and production of fully degradable mbb
base metalcatalytic crosscoupling methodologies towards sustainability

catalysis is today exploited for preparing ca 90 of chemical and pharmaceutical products use of catalysts allows for efficient chemical transformations limiting the energy consumption and improving selectivity and atom economy however a large number of catalytic systems rely on noble metals eg pd pt rh ir au with associated sustainability and toxicity issues indeed all these metals are undergoing strong price fluctuations and will face supply limitations in the future moreover given the toxicity of most precious metals the tolerated threshold in fine chemicals and apis is very low with associated purification costs solvents energy generation of waste for these reasons replacement of noble metals with the cheaper and generally less toxic 1st row transition metals tms such as mn fe co ni cu is becoming a compelling goal for chemists as well as a need for society however this goal also represents a tremendous challenge as the typical reactivity of 2nd and 3rd row tms cannot be easily transferred to 1st row tms due to their different electronic structure the socalled base metals tend to form high spin complexes and to engage in single electron transfer rather than in the multielectron redox steps typical of noble metalsnextbase is an intersectoral consortium of research groups with a strong expertise in catalysis who will join forces to take the challenge of noble metal replacement in crosscoupling reactions a class of transformations of high industrial importance for the production of fine chemicals and apis synergies and complementary types of expertise within the dn will be exploited i to harness the reactivity of 1st row tm for several types of crosscoupling which will be also applied to industrially relevant targets and ii to train phd students aware of the importance of sustainability issues and expert in the use and combination of sustainable catalytic methodologies
a quantitative study of periodic patterning in growing multicellular tissues understanding trichome development

the development of living organisms involves tightly coordinated regulatory mechanisms that reliably instruct each cell type tissue and organ to perform specific functions this is achieved through an elaborate interplay between pattern formation cellular growth and division patterning processes occurring as cells grow and divide are present in many biological systems these include the generation of digits in the vertebrate limb and the specification of trichomes in the leaf epidermis of arabidopsis among many other examples still the effect of cellular growth and division on pattern formation remains poorly understood because of the difference in time scales pattern formation and growth have been typically studied separately however in many developmental processes these two time scales are comparable and the effect of growth on patterning must be considered explicitly in this project i will combine quantitative image analysis mathematical modelling and computer simulations to understand the interplay between cellular patterning and growth by focusing on trichome development trichomes constitute an optimal model to test fundamental principles of pattern formation in growing tissues because there is a good understanding of the underlying gene regulatory networks and the pattern formation process can be tracked over time this project will be developed in collaboration with leading experts in the field the hülskamp lab providing the experimental data and the fleck lab providing the theoretical expertise in the regulatory networks underlying trichome patterning the findings resulting from this project will elucidate general principles of pattern formation in plants and other living organisms during tissue growth
the pharmacomicrobiomics of depression

this interdisciplinary project aims to improve response to depression treatment using the gut microbiota about one third of patients with depression do not respond to treatment with selectiveserotoninreuptakeinhibitors ssris moreover side effects such as gastrointestinal complaints are common the commensal gut microbiota residing in the human intestinal tract in trillions likely contribute to variation in treatment efficacy this makes them a promising candidate to improve treatment response the highly interindividual variable gut bacteria collectively represent an enormous amount of genes enzymes and transporters outnumbering human genes by 10100 times hereby the gut microbiota are involved in processing of orally ingested compounds and through the communication highway called the gutbrainaxis interact with the central nervous system antidepressant medication such as ssris reduce gut microbial diversity and change community dynamics for example in vitro studies have shown unintentional effects of ssris in the gut on a bacterium with a humananalogous serotonin transporter this negatively affects serotonin metabolism in the gut potentially contributing to side effects and reduced treatment response other similar mechanisms may occur yet very limited experimental experimental data exist mapping which and how gut microbiota are impacted by ssris moreover hardly any studies link ssri medication induced gut microbial effects to treatment response using clinical cohorts i will dissociate gut microbial profiles of patients responding versus not responding to their ssri medication in a culturing experiment fecal material of such responders and nonresponders will be characterized in terms of growth profile after ssri exposure transcriptomic and metabolomics using these results a probiotics product will be developed this project contains clinical microbial and applied work with great societal and economic potential
axiles bionics solaris project

lowerlimb amputees face physical and psychological pains that marketed prostheses are unable to relieve axiles bionics aims to fill the clear worldwide market gap with nextgeneration bionic prostheses combining advanced robotics ai ensuring complete adaptation to amputees lifestyle by virtue of its features our technology creates a revolutionary costeffective market concept prostheticsasaservice praas with our solaris design our praas model ensures componenttocomponent maintenance daily data gathering monitoring system predictive maintenance and continuous upgrades the fitness to the jobtobedone of our solution has been already proven by inhouse studies where more than 85 of tested subjects expressed their astonishment and defined it as a musthave data from these studies show significant increase natural gait less peripheral pains kneeshipsback and restoring of physical and mental balance clear proof of the superior added value of our solution
identifying the role of injuryassociated cellular reprogramming in the early oncogenic transformation of human colonic epithelium

colorectal cancer represents a major public health problem being the second leading cause of cancerrelated deaths worldwide the treatment management of the already developed disease is however often timeconsuming expensive and rarely 100 effective therefore the goal should be to start diagnosing and managing the diseased state as early as possible when cancer is still curable the early cellular transformation events remain poorly understood as cancerassociated mutations have been found to be surprisingly prevalent in seemingly healthy tissues suggesting the requirement for a potent trigger mechanism with this project i aim to study the early colonic transformation via a completely unique hypothesis and approach my strategy is built on the emerging new injurytriggered fetallike state concept guided by my host lab and the hypothesis that oncogenic mutations require transcriptional reprogramming to a more susceptible fetallike state to trigger transformation this hypothesis relies on the fact that the fetallike state is observed during injury and also in subsets of tumors indicating that cellular reprogramming could play a prominent role in promoting oncogenic transformation as a primary model system i will make use of my extensive experience with cancer modeling via 3d humanderived organoids and crispr technology and elevate these techniques by the stateoftheart expertise available at the host lab andor institution such as in vivo orthotopic cell transplantation epigenetic profiling advanced crisprscreening methodology and clinical collaboration by bringing together such intelligent methodology i will be able to effectively investigate the role of injuryinduced cellular reprogramming in the transformation of human colonic epithelium the results of this work will shape the future directions of my own prospective lab but also cancer research in general promising major new implications on early cancer detection strategies
advanced 5g open platform for large scale trials and pilots across europe imagineb5g

the evolution of mobile telecoms networks beyond5g creates a tremendous opportunity for europe to establish leadership in innovation by addressing the requirements of use case from ppdr smart agriculture media ehealth education transportation logistics industry 40 and energy sectors imagineb5g project aims to create an advanced and accessible endtoend e2e 5g platform for largescale trials and pilots providing a set of b5g applications enabled by the integration of advanced 5g disrupting technologies the project will support 3gpp rel17 and beyond features which are crucial for implementation of private networks under reallife operational conditions to enable advanced 5g services which are driven by the industrial needs and requirements of a wide variety of verticals the functionalities built into the b5g platform will enable these advanced 5g vertical applications to be demonstrated at scale and will allow the project to identify and validate new 5g kpis key performance indicators and kvis key value indicators across three different but equally fundamental domains societal application and management all kpis and kvis will be verified as relevant to the use cases supported through demonstration of their importance to endtoend largescale trials and pilots imagineb5g brings together four advanced 5g experimental facilities in norway spain portugal and france these facilities will capitalise on previous 5gppp infrastructure ict17 and vertical trial projects ict19 reusing the platform components and extending the existing capabilities of these facilities this will ensure a successful implementation of snsd0101 goals and expected outcomes the imagineb5g strategy to achieve this is built up implementation of the latest 5g rel16 technology enablers the project is envisioned to become an incubator facilitating technology innovations and a diverse set of advanced 5g applications services and ecosystem developments
the evolution of early symbolic behavior

understanding the unique evolutionary trajectory taken by the human species is impossible without appreciation of our special capacities for symbolic cognition and behavior but how did these capacities evolve during the late middle palaeolithic within only the last couple of decades early milestones in human symbolic behavior have been continuously revised as new excavations across the globe challenge previous longheld assumption however at the same time we have made little progress in our understanding of past symbolic behaviour and the mechanisms by which it evolved as tools of the mind symbols are constituted by the intangible cognitive processes they evoke in pragmatic use contexts which are inaccessible to the standard methods of archaeology or genetics with esymb i will establish a novel integrative framework for the systematic investigation of early symbolic evolution directly frontloading records from archaeology in experimental investigations and computational modelling based on stateoftheart methods from the cognitive sciences starting from the assumption that symbolic artefacts evolve adaptively over time to better fulfil their intended functions i will investigate these structural changes and their cognitive implications to inform inferences about their past use the framework will thus establish transparent datadriven methods and criteria to test for the first time concrete hypotheses about early human symbolic behaviour from 6 archaeological sites from the late middle and early upper palaeolithic 150000 12000 years ago based on measures critical to symbolic cognition and behaviour in summary the objective of esymb is to bring systematic scientific rigour to the investigation and interpretation of early human symbolic behaviour particularly from
exploiting single cell long noncoding rna biology to target therapyinduced senescence in lung cancer

noncomicrotis will combine new findings in long noncoding rna lncrna biology with cutting edge research to uncover innovative therapeutic opportunities for the treatment of lung cancer one of the most prevalent and deadliest types of cancer worldwide current treatments which are often insufficient include the use of chemotherapy and radiation that induces tumor cell arrest this process termed as therapyinduced senescence tis has been considered a positive outcome for cancer therapy however there is evidence that tis can be reversible leading to an aggressive phenotype and disease relapse the low percentage of senescent cells in the tumor together with the lack of specific markers senescence senescence has prevented the development of methods to identify and target this population of cells i will exploit the highly specific expression patterns of lncrnas by tailored single cell methods to identify therapyinduced senescent cells and their relationship with the tumor microenvironment further noncomicrotis will investigate the senescencerelated roles of small peptides produced by tislncrnas to be exploited for the targeting of these singular cells within lung tumors altogether my study will define a new senescence signature using specific lncrnas that will help to identify senescent cells and will provide information on how these cells impact the neighbouring populations moreover it will uncover mechanistic roles of micropeptides in the regulation and targeting of senescent cells and will provide the basis for the use of micropeptides as therapeutic targets noncomicrotis will combine cuttingedge techniques in transcriptomics and molecular and cellular biology techniques resulting in an original multidisciplinary project with high potential for groundbreaking findings furthermore it will allow me to reach the level of professional maturity needed to become an independent researcher
fair information cube

the core objective of fairicube is to enable players from beyond classic earth observation eo domains to provide access process and share gridded data and algorithms in a fair and trustable manner to reach this objective we propose creating the fairicube hub a crosscutting platform and framework for data ingestion provision analysis processing and dissemination to unleash the potential of environmental biodiversity and climate data through dedicated european data spaces within this project trl 7 will be attained together with the necessary governance aspects to assure continued maintenance of the fairicube hub beyond the project lifespanthis projects goal is to leverage the power of machine learning ml operating on multithematic datacubes for a broader range of governance and research institutions from diverse fields who at present cannot easily access and utilize these potent resources selected use cases will illustrate how datadriven projects can benefit from cube formats infrastructure and computational benefits they will guide us in creating a userfriendly fairicube hub which is tightly integrated to the common european data spaces providing relevant stakeholders an overview of both data and processing modules readily available to be applied to these data sources tools enabling users not intimately familiar with the worlds of eo and ml to scope the requirements and costs of their desired analyses will be implemented easing uptake of these resources by a broader community the fair sharing of results with the community will be fostered by providing easy to use tools and workflows directly in the fairicube hub
lessen data access and governance obstacles

lago will deliver the foundation for a trusted eu ftc research data ecosystem rde to address the socalled data issue in the fct research landscape ie the lack of domainspecific data in sufficient quality and quantity to enable appropriate training and testing of the developed methods platforms and tools lago will be instrumental in identifying common barriers and subsequently providing the structural governance and technical foundations to foster and innovate dataoriented research collaboration among leas security practitioners relevant eu agencies academic and industry researchers policy makers and regulators for this purpose lago will develop an evidencebased and validated multiactor reference architecture for the fct rde for these actors to deposit share and cocreate data and tools for fct research purposes based on common rules protocols standards and instruments in a trusted and secured environment the envisaged reference architecture and accompanying governance framework will be based on the design principles of decentralisation data sovereignty data quality openness transparency and trust and comply with eu values and principles on data protection privacy and ethics the reference architecture will be accompanied by a trl7 reference implementation of addedvalue technological tools to ensure practical realisation of the reference architecture as multiple data spaces and across the full range of concrete usage scenarios a roadmap will finally provide the consolidated rules conditions and considerations for the actual deployment of the eu fct rde the ultimate ambition of lago is to go beyond the creation of a common repository in order to innovate the fct dataoriented research sphere by creation the crucial foundations for the sustainable safe and trusted creation cocreation sharing and maintenance of training and testing datasets for the fct research domain
integrated photonic circuit fabrication by femtosecond laser writing for quantum information

quantum technologies promise to revolutionize the way we acquire manipulate and communicate information photons are key players in quantum technologies with a transversal role in all applications in particular integrated photonics is the only viable approach to scale up quantum photonics to the level of realworld applications in this context many materials and fabrication tecnologies are being explored among them femtosecond laser writing of photonic circuits in transparent glasses is a powerful microfabrication technique with several advantages that could particularly benefit quantum applications in particular in a rapidly developing field such as that based on quantum technologies there is a great need for rapid prototyping easy customization and versatility in terms of layouts materials and applications all these features are specifically provided by femtosecond laser writing in this project we would like to build from several key device demonstrations achieved in the main erc advanced grant to develop their potential for commercial exploitation in the globally expanding market of quantum photonic devices femtosecond laser writing has already demonstrated its industrial viability with several existing companies based on this technology however none of them tackles the market of quantum integrated photonic devices the pi and his team have a longstanding experience in designing and producing integrated photonic devices for quantum applications the photonfab project will focus on improving the production capability in terms of circuit complexity efficiency and packaging together with a thorough market and ipr analysis contacts with potential end users and stakeholders and detailed cost estimation this project will help shaping the exploitation strategy of the many groundbreaking results achieved in the erc advanced grant project
understanding pesticidepollinator interactions to support eu environmental risk assessment and policy

pollinera aims to reverse pollinator population declines and reduce the harmful impacts of pesticides it addresses the call through four objectives so1 filling ecotoxicological data gaps to enable realistic prediction of the source and routes of exposure and impact of pesticides on pollinators and their sensitivity to individual pesticides and mixtures so2 developing and testing a comonitoring scheme for pesticides and pollinators across european cropping systems and landscapes developing risk indicators and mixture exposure information so3 developing models for predicting pesticide toxicological effects on pollinators for chemicals and organisms environmental fate toxicokinetictoxicodynamic and population models so4 developing a populationlevel systemsbased approach to risk and policy assessment considering multiple stressors and longterm spatiotemporal dynamics at the landscape scale and generating an open database for pollinatorpesticide data and toolsthis will be achieved through developing knowledge and protocols for a broad range of toxicological testing feeding to in silico models qsars toxicokinetictoxicodynamic and population using a strong stakeholder codevelopment approach these models will be combined in a one system framework taking a systems view on risk assessment and policy evaluation including an international monitoring programthe one system framework is based on efsas system era view expanding on the tools used for bees to include butterflies moths and hoverflies the consortium partners are experts in the field needed for this development and are wellplaced to facilitate the uptake of tools by european bodies to guarantee the projects future impactexpected impacts target destination impacts of better understanding and addressing drivers of biodiversity decline interconnected biodiversity research using digital technologies and understanding the biodiversity and health nexus at the ecosystem level