Dragon09/odtu_chatbot huggingface dataset:
putting the top down on ampk protein complex

the 5 adenosine monophosphateactivated protein kinase ampk is a master regulator of cell energy metabolism ampk dysregulation has been connected to metabolomic disease conditions of the heart and viral infections ampk is finetuned through its structural features which are dependent on mrna isoform splicing protein complexation posttranslational modification ptm and allosteric activation ampks diverse regulatory role is deeply connected to its posttranslational modifications 43 known phosphorylation and 36 known other ptm sites the result of this structural diversity is an extremely large combinatorial space of 1 unique covalently modified isoforms the proteoforms and 2 their unique noncovalent assemblies the complex species however the structural diversity of ampk is not well understood the goal of this project is to to study the modifications and endogenous diversity of ampk proteoforms and complex species from a birds eye view depicting and mapping in parallel existing complete length ampk forms using denatured and native topdown mass spectrometry tdms outgoing phase ying ge lab university of wisconsinmadison uwm m124 recombinant ampk complex to study coded proteoforms o12 and establish a strategy for purification of endogenous ampk o3 incoming phase m2536 charlotte uetrecht lab university of lübeck uzl transfer learned technologies and map endogenous ampk proteoforms in different tissues o4 design endogenousike ampk proteoforms o2 nonacademic phase m3742 bruker daltonics gmbh bruker close gaps in data acquisition and get more out of ampk with nextgen ms instruments o2the aspired methodology and results will be important for the identification of ampk biomarkers and ultimately for the advancement of precision medicine where treatment is tailored for the individual molecular setup of a patient subgroup such as in metabolomic or heart disease
quantum sensing with metalorganic frameworks dft molecular dynamics and machine learning exploration

metalorganic frameworks mofs are composed of metal ions coordinated with organic ligands to form porous structures with high surface areas making them suitable for a wide range of industrial applications for instance mofs exhibit sensitivity to various molecules and gases due to their high surface area and tailored pores as such they can be employed in gas sensors for detecting volatile organic compounds environmental pollutants and toxic gases enabling important applications in environmental monitoring and industrial safety despite the incredible success of mofs as a sensing strategy and sequestration agent only macroscopic quantities of segregated compounds can be effectively sensed my project sensing with quantum organometallic frameworks sequoia will pave the way to the exploitation of quantum sensing for the detection of traces of gasespollutants in air and water by exploring the potential of mofs decorated with molecular quantum sensors quantum sensing is an emerging area of quantum information science that enables the measurement of physical properties using quantum objects qubits quantum sensors are far more precise than their classical counterpart potentially allowing them to probe a vast range of physical properties from magnetic fields to gravity with unprecedented sensitivity in particular molecular qubits represent one of the latest frontiers of spinbased quantum sensors where long spin coherence times are combined with chemical versatility and the possibility to tailor molecular structures in order to tune the sensors properties and tailor sensortarget interactions sequoia will bring together a diverse set of advanced simulation techniques such as quantum chemistry machine learning and ab initio spin relaxation theory to deliver an unprecedented computational characterization of the properties of mofs in realistic environments and thus provide a blueprint for the realization of this cuttingedge technology
pannexin 1 a novel target for pediatric orphan epilepsy

epilepsy is a group of syndromes with high unmet medical need especially in children as frequent seizures affect the immature brain and its development in some orphan syndromes drug resistance is 70 with dramatic consequences for patients and their families novel treatments must prevent the negative effects of seizures but also minimize offtarget effects on brain development and cognitive functions our solution is the specific blockade of the activated form of the pannexin 1 panx1 channel using a reformulated form of probenecid pti5803 this compound a firstinclass drug inhibits seizures preclinically in 80 of cases without hampering cognitive functions designed to be adapted to children from 6 months of age and to improve the bioavailability pti5803 is a highly specific breakthrough product to counteract the pathological activation of panx1 in patients with an ultraresistant orphan epilepsy with the potential to disrupt the market of paediatric epilepsy
coreactantfree electrochemiluminescence immunosensors for onfarm diagnosis of viral infectious diseases eclfarm

there are no quantitative electronic diagnostic devices for early and rapid detection of infectious animal diseases onfarm eclfarm proposes the development of a highly novel sensor technology ie a coreactantfree onchip electrochemiluminescence ecl immunosensing technology to deliver a simpletouse portable rapid and multiplexed detection system for disease detection onfarm in this project bovine viral diarrhoea bvd a worldwide disease with severe financial and welfare implications for the beef and dairy industries is selected to demonstrate the efficacy of reagentless ecl detection onfarm current lateral flow tests for bvd typically rely on a single target either virus or antibody not both within an individual test sampleeclfarm will use the complementary and distinct skillsets of the team to achieve three key project objectives 1 development of onchip ecl at nanoelectrode arrays to provide a sensitive coreactant free solidstate ecl system suitable for reagentless onfarm disease diagnosis 2 implementation of multiplexed ecl competitive offon mode immunoassays of bvd virus and antibodies multimodal diagnosis with very low detection limits and 3 benchmarking and demonstration of a fully integrated phonebased ecl device for onfarm testing of serum existing samples and milk samples a farmfriendly application the sensor format will be adaptable offering potential application in other animal and human diseases in the future and will be scalable to facilitate inclusion of additional assays for diseases associated with other viral parasitic or bacterial pathogens along with technical learning a range of transferable skills will be acquired through the designed career development plan as a result of my holistic growth in this project i will be able to mature professionally and become an independent leader in the field of smart nanoecl devices for pointofcare diagnostics applications
the mouse village a fully automated behavioral system for continuous social and cognitive testing

drug discovery in mental health is undergoing a crisis characterizing a new generation of biomarkers for the different disorders seems the promising path towards developing new treatments biomarkers including behavioral biomarkers are quantitative observables that are altered and can be used for diagnosis prognosis or treatment response monitoring importantly for preclinical research these biomarkers should be translational and work across species but experiments in rodents are largely based on paradigms that are disparate from those used in humans training rodents in more humanlike tasks has a strong translational potential but it has important shortcomings it requires developing finelycontrolled tasks involving long training periods consuming lots of animals and ultimately inducing very elevated personnel costs to confront this experimental bottleneck neuroscience and pharmaceutical laboratories are trying to automatize their methods but still most systems rely on human intervention require animal manipulation and impose a high maintenance toll leveraging our experience building behavioral systems during our erccog2015 we will design build and distribute the mouse village mv a new fullyautomated open platform in which mice selftrained 247 in different cognitive tasks while displaying complex social interactions without human intervention the mv consists in a system of cages connected to an operant touchscreen chamber that can implement multiple cognitive tasks we will build on a previously developed pilot mv by introducing a more modular and flexible design and validate the system using several standard social and cognitive tests the mv will be shared to the community under and open software and hardware licenses by eliminating the experimental bottleneck imposed by behavioral experiments the mv has the potential to accelerate the search for new biomarkers of brain disorders and have a substantial impact on mental health
multifunctional cavity mirrors for nextgeneration ultrastable lasers

ultrastable laser cavities uslcs lie at the heart of humankinds most precise measurement instruments developing compact multiwavelength uslcs will greatly benefit applications such as quantum sensing spectroscopy metrology and quantum computingin this research program i propose to explore novel versatile cavity mirrors by integrating lownoise metadevices with multilayer photonic integrated circuits into complex laser resonator geometries i envisage a fully integrated uslc by incorporating all necessary sensors modulators and inputoutput optics within the mirror substrate innovative laser resonator topologies will allow for pushing the stability limits into new regimes and gaining access to novel application fields of optical cavities we have recently demonstrated an optical cavity incorporating an ultralownoise metamirror with an unprecedented cavity finesse of 11500these developments are possible thanks to our theoretical framework to model thermal noise processes in arbitrary optical systems highrefractive index materials like silicon diamond silicon nitride and aluminum oxide are ideal for realizing lownoise metadevices and integrated photonic circuits the enormous conceptual and technological challenges lie in simultaneously controlling many properties optical optomechanical thermal in complex photonic configurations incorporating different materials and addressing various temperature ranges and multiple wavelengths within a single miniaturized cavitythrough its research program the mightymirror project will enable a symbiosis of integrated photonics and freespace cavities opening many new possibilities with a large impact on fundamental and applied science as well as on society
energy transitions and the rise and fall of great financial centers

for all their differences modern nationstates are both the energy transition leaders and financial leaders of their time they are also home to our great financial centers gfcs and the question of the rise and fall of gfcs is a matter of longstanding debate existing explanations struggle to explain the timing and forecasting of the rise and fall of gfcs in a systematic manner no researcher has connected the dots between energy transitions financial transitions the role of financial systems and the rise and fall of great financial centers my nontraditional hypothesis is that energy transitions drive financial transitions and gfcs the core aims of enfin are create a new field of research integrating elements from comparative institutionalist literature sociotechnological transition research and research on financial centers a integrate the role of energy transitions in the literature on financial centers i will use crossnational and crosstemporal comparisons to establish the sequences and relationship between energy transitions and financial transitions b lift the analytical power of sociotechnological transition research with regard to the reciprocal logic of lowcarbon energy and green finance transitions i will examine causal mechanisms through inductive process tracing on evidence about the pressures arising from energy transitions on existing financial structures and socioeconomic actors responses c investigate the role of institutions in the relationship between greenenergy transition and future financial leadership i will conduct convergence analysis to develop a global database to compare green financial standards by countries and a multigroup latent growth curve lgc model to compare and predict growth trajectories of multiple groups eg coordinated market economies capital market economies and state driven economies in financial systems over time
european network to empower research on capacitors

supercapacitors are a promising solution for fast charging and regenerative energy acquisition with potential market applications in the near future incl evehicles and space applications a deep analysis of the supercapacitor technology and market state of the art was undertaken by enercap as a sound basis for a training network that meets academic and industrial needs the results revealed that the lack of novel materials and electrolytes that meet the industrial requirements of higher energy densities and the lack of new industrially compatible materials processes and prototypes are major challenges towards a successful market introduction of the supercapacitor technology it became evident that europe currently lags behind the usa and asia in supercapacitor innovation and market performance due to the lack of intersectoral and interdisciplinary collaboration between academia and industry a clear barrier for technology transfer and bringing innovation to the market as a response to these challenges enercap gathered for the first time the most renowned academic players in the field together with driving force companies in order to create a european network to empower research on the field of capacitors ensuring technology transfer furthermore enercap aims to by means of an innovative training network create a critical mass of future topclass researchers able to respond to innovation challenges in the field of supercapacitorsenercap is devoted to provide future researchers with the skills to produce innovative ideas that can be transferred to market applications through a comprehensive training programme driven by the needs of industry esrs will not only be provided with necessary interdisciplinary knowledge and research techniques but become entrepreneurially spirited researchers who own a broad range of transferable skills and are able to envisage the needs of markets and endusers while being at the frontier of research
characterising multistage landslide activity rates with synthetic aperture radar satellite data

landslides are a significant hazard in mountainous environments the advent of earth observation from space has hugely increased the scope of landslide studies and improved our understanding in terms of hazard mitigation early warning triggering mechanisms and masswasting effects occurrences of new landslides can be observed in optical satellite images while slowmoving landslides can be monitored using satellite radar interferometry insar however while the spatial coverage of landslide studies has been expanded by the availability of remote sensing datasets a complete picture of landslide activity remains difficult to obtain from satellite imagery optical satellite images are bestsuited to detection of new landslides in vegetated environments while insar is limited to slowmoving landslides current methods therefore struggle to detect multistage failure or reactivation of preexisting landslide scars for fastmoving or incoherent deformation here i will develop new sarbased techniques using amplitude and coherence time series to detect multistage failure and reactivations i will test and apply these techniques at a range of spatial scales individual large landslides up to regional inventoriesi will apply to techniques to two case study areas nepal and papua new guinea that have experienced landslides triggered by sequences of both earthquakes and rainfall the case where landslides are triggered by a sequence of events is one where detection of multistage failure is particularly important whether a landslide fails once or several times has implications for both hazard and erosion by applying the new methods here alongside traditional remote sensing techniques we hope to obtain a more comprehensive view of landslides than is currently possible
applying photon upconversion in rotaxanes for superresolution microscopy analyses

this multidisciplinary aurora project focuses on the development of prototype rotaxane molecular ringonthread structures displaying triplet fusion upconversion photoprocess structural design will instill this process via spontaneous excited dye collisions in confined trajectories of the designed interlocked molecules to create a fluorescent state from two combined low energy photons such architectures will help to collect information on molecular photon upconversion and intramolecular diffusion processes through timeresolved spectroscopies moreover it will produce intermittent fluorescence blinking by which detailed analysis will afford a new methodology for superresolution imaging namely below the diffraction limit of light in theory this can provide solutions to some limitations of actual approaches and impact this research field fluorescence modulation within these autonomous 2rotaxanes by triplet fusion will lead to studies down to the singlemolecule level based on stochastic optical reconstruction microscopy which will be employed to establish a new localization microscopy method t2storm and be validated through imaging commercial nanostructured biomacromolecules both leading french research institutes institut des sciences moleculaires ism and laboratoire photonique numerique et nanosciences lp2n will cohost the aurora project the french fellow specialist in synthetic organic and supramolecular chemistry will be taught molecular photophysicsphotochemistry and superresolution fluorescence imaging additional work packages will guarantee efficient scientific advances training career development management communication and potentially technology transfer association of the fellow and research groups skills at the chemistryphotophysicsimaging interface available infrastructure and equipment will participate to both the fellows future independent research career and achieving ambitious aurora objectives
flowreactor coupled 3d printing achieving voxellevel control of outofequilibrium materials

nature has optimized the properties of its building blocks by spatially varying hierarchical microstructures within complex form factors additive manufacturing techniques in particular direct ink writing diw are promising pathways towards replicating these systems synthetically leading to printed materials with tarilored materials properties however current diw techniques do not offer access to outofequilibrium materials greatly limiting printable microstructures to overcome this limitation a new diw technique termed flor3d will be developed in this project by integrating an evolving chemical reaction into the printing process itself this flowreactor coupled 3d printing technique allows for outofequilibrium microstructures to be generated within the nozzle which is subsequently trapped upon deposition through onthefly variations of the relative flow rates into the flow reactor flor3d will allow for voxellevel control of the material composition and microstructure resulting in optimized and spatiallyvaried hierarchical structures by incorporating a polymerizationinduced microphase separation pims process spinodallydecomposed bicontinuous microstructures which was previously unachievable by diw will be printed printing these bicontinuous systems commonly used in nature to exhibit structural coloration will result in angularindependent structural colored materials with arbitrary form factor furthermore by including photoresponsive monomers within the pims system and an insitu uv source the materials refractive indices can be tuned independently of the microstructural feature size resulting in materials with gradient and spatiallypatterned optical properties ultimately beyond the complex photonic materials produced in this proposal the design of flor3d can be broadened to incorporate a variety of other chemical reactions leading to a new pathway towards freeform highperformance materials
semiconductor free biophotoelectrodes for solar fuel production

the soaring demand for energy and use of fossil fuels has resulted in the release of vast amount of greenhouse gases and climate change developing photoelectrochemical devices for solar fuel production is one of the strategies to address these issues the use of photosynthetic proteins as photoactive components could potentially generate highly efficient biophotoelectrodes built exclusively from earthabundant elements leading to a step change in sustainable solar fuel production the extreme electron transfer rates quantum efficiency and large charge separation of the photosynthetic protein complex photosystem 1 delivers the high energy electrons needed for co2 fixation or h2 evolution in nature however coupling electron transfer between electrodes and photosystem 1 to catalytic processes remains challenging because charge recombination of the reduced electron acceptors with the oxidized form of the electron mediators or with the electrode surface is typically faster than catalysis the overarching aim of superset is to demonstrate for the first time the concepts of kinetic barriers and fast hole refilling through electron hopping for preventing charge recombination in scalable biophotoelectrodes and thus enable co2 reduction and h2 production with semiconductorfree devices toward this aim my specific research objectives will include 1 design electron acceptors based on anthraquinones to limit recombination at the electrode by taking advantage of their pcet square scheme mechanism 2 modify the surface of electrode by selfassembled monolayers to build a charger barrier to prevent the charge recombination of the reduced electron acceptors with the electrode 3 design osmiumcobaltbased electron donors with extremely fast electron transfer to enable the refilling of the hole produced by photosystem 1 before recombination takes place 4 combine the electron donor and electron acceptor to be channeled to an enzyme for co2 reduction or h2 production
innovation technology rating system and digital hub

the innotechrate project aims at reducing information asymmetry and cognitive biases between innovators and private and public funders on the evaluation of innovations this will strengthen the capacity of the european innovation ecosystem to support innovative deeptech startups through a better identification of high potential projects in relation to risks and allocation of resources to highly innovative projectsin this perspective the innotechrate project will adapt technology rating tools already developed by the innovation loop and embed them on a digital platform this digital platform will be designed as a hub linking project holders investors intermediary organisations and experts this platform will allow project holders and investors to perform a technology rating of innovation projects in a simple and fast waythe technology rating system will be 100 data driven and will be powered by artificial intelligence this will allow the objectiveness in the collection the checking and the analysis of all data related to innovation projects a link to traditional financial rating will be explored a free and online version of technology rating tools will be made availablethe innotechrate project will also develop a reference framework for the technology rating of innovation projects based on a consensus of european stakeholders and integrating the european societal and environmental challenges this common reference framework should be common for project holders and investors it holds the ambition to become an accepted standard and norm within the european innovation ecosystem