Dragon09/odtu_chatbot huggingface dataset:
era chair in data spaces for cultural heritage

dispatches aims to establish an era chair in data spaces for cultural heritage in gate institute big data for smart society at sofia university st kliment ohridski gate institute is a center of excellence in big data and artificial intelligence and one of the eight european data space hubs of the international data spaces association the european data space for cultural heritage is in its initial stages and a programme of focused research and strong crosssector collaboration will contribute to the ongoing shift in the digital cultural heritage domaindigital cultural heritage is not within the current portfolio of gate but it can bring into this domain its expertise on data spaces from other areas including smart cities attracting as a potential chair professor seamus ross currently in the university of toronto canada gate seeks to achieve substantial boost in its expertise adding data spaces for digital cultural heritage to its portfolio increasing its excellent staff members number by 9 and its visibility with over 30 high quality new publications supporting the structural reforms in the host institution which would further help to strengthen its pockets of excellence reverting the brain drain and offering opportunities for early stage researchers including 5 phd students demonstrating the various aspects of open science and sharing with the wider university community especially within the humanities where open science is underusedestablishing the unit as a permanent one by the end of the project will help to consolidate the currently dispersed digital cultural heritage expertise at the host enhance the gate institute excellence and the diversity in its staff and contribute to the efforts for creating european data space in cultural heritage
sure2coat sustainable surface treatments of complex shape components for transsectorial industrial innovation

light alloys like al have shown to be good options for replacing steel in many sectors due to higher thermal conductivity and weight reduction they allow which has become crucial eg for emobility however without protection recycled al is prone to corrosion under operation in harsh environments eg heat exchangers in heat storage units components in motors needed to be frequently cleaned with harmful chemicals the sure2coat project will enable the use and uptake of al in new sectors involving products with complex shapes by new sustainable manufacturing methods with lower energy consumption for end users corrosion is a major challenge with an annual global cost of 25 trillion it is therefore fundamental to develop and validate new surface treatments to produce corrosion resistant and conductive coatings for new applications sure2coat will develop and validate new surface treatments for light alloys anaphoretic ecoating laser structuring compositepeo coating in three use cases in which energy usage is key electrical engines heating systems and heat storage units sure2coat pays special attention to effective design for future integration into their respective production lines sure2coats target is to increase the energy efficiency by 5060 and increase the use of recycled al by 70 by using surface treatments and innovative production technologies casting virtualisation with lower energy consumption from 10 during manufacturing for an industrial point of view a prerequisite for succeeding is continuity in manufacturing rdi projects and trainingeducation of required staff which sure2coat will foster by broad dissemination and exploitation of the project results across the manufacturing value chain sure2coat will result in strengthening the european manufacturing value chain by developing european industries with leadingedge technologies on manufacturing materials and allowing for accelerating rollout for green transition
gravitational wave detectors cooled with superfluid helium

gravithelium addresses the central technology challenge in third generation gravitational wave 3g gw detectors proposing to cool the core optics of cryogenic detectors with superfluid helium the einstein telescope et will be the future european 3g gw observatory designed to observe the whole universe it has entered the european esfri roadmap in 2021 and is supported by the major international roadmaps et includes new technological challenges on the verge of feasibility particularly in the cryogenic lowfrequency interferometer etlf that is crucial to exploit the full scientific potential cryogenic operation of the etlf payloads at 10 k to 20 k is indispensable to suppress the fundamental suspension thermal noise stn to the level of newtonian noise requiring new key technology developments in ultralow noise cryogenic cooling cryopumping and thermal shieldinggravithelium aims for the experimental proof of a pioneering concept that proposes cryogenic payload suspensions filled with superfluid helium as the quantum fluid heii is the thermal reservoir that absorbs and conducts heat in the quietest possible manner motivated by the theoretical proof of concept experiments on dissipative mechanisms and their stn contributions in heii filled payload suspensions will be conducted for this purpose a new test facility for cryogenic qmeasurements will be build which will also deliver data on dissipation in fullsize solidstate suspensions at low temperature needed in the gw detector community for the development of etlf payloads the project further focuses on a new technology development for the attenuated and forcefree supply of helium to the cryogenic payloads cooperating with a worldleading industry partner gravithelium will thus achieve significant advancements in one of the key technologies to enable future frontier science with et providing also essential physical data for the modelling and engineering design of etlf payloads
making old objects valuable again the cultural economic challenges and sustainability opportunities of antiques in the 21st century

what do old porcelain wooden furniture and silverware have in common all of these antiques fall into the category of informal heritage regardless of their cultural significance many of these objects remain on the margins both in cultural institutions and scholarly research as a result the question of how antiques are safeguarded valued traded perceived and consumed remains largely underexplored by studying the contemporary economy of antiques moovas prime objective is to highlight the potential of these objects regarding the safeguarding and promotion of informal heritage sustainable consumption new business models for ageing sectors and local city development more specifically moova aims to 1 demonstrate the patrimonial role of antique dealers as vital safeguarders of informal heritage 23 explore the market structures at play within the antiques trade its economic impact and the supply and demand for antiques in a digital economic context 4 understand how antiques are perceived by younger generations gen z and 5 develop a theoretical and practical model for renewing the meaning and value of these complex objects through selected case studies european decorative arts and a multitransversal approach crossmarkets objects countries the project will combine theories data and methods from art history cultural economics cognitive science and arts marketing to investigate this topic holistically the first stage will consist in data collection and processing using new databases of evidence drawn from primary and secondary sources incl interviews and sales results while the second will be dedicated to the development of the reevaluation model moovas overreaching goal is to progress towards more advanced scholarship in art market studies by providing tools that better fit the idiosyncrasies of markets for complex cultural goods and to address issues related to art education audience renewal and job opportunities
activation and switch of fates in t lymphocytes

antigenstimulated nave cd8 t cells proliferate and differentiate into effector and memory cells whereas effector t cells remove infected or cancerous cells memory t cells protect the organism from reinfections despite decades of research the challenging central questions of how nave t cells form diverse progeny and what drives the differential response of nave and memory t cells to infection remain unanswered largely because of lacking experimental toolsthe goal of this project is to generate a comprehensive model of cellfate choices of nave and memory cd8 t cells in vivo we will achieve this by addressing three complementary specific objectives1 to understand the early and late fate choices in nave t cells2 to uncover differences between nave and memory tcell responses and fates3 to identify the role of proximal protein kinases lck and fyn in tcell fate choiceswe will pursue these aims using a combination of experimental immunology and systems biology we used the synergy between novel genetic models and single cell atlases i to characterize an unprecedented transient stage of activated t cells ii to determine the early gene expression signatures and fate choices of in vivo activated nave and memory t cells and iii to observe that lck secures memory tcell formation these tools and findings offer us novel perspectives to tackle the challenging objective in its full complexity we will develop additional unique experimental models coupled with innovative insilico techniques to uncover the cellular and molecular mechanisms underlying diverse fate choices of particular tcell subsets and to narrow the gap between mouse and human immunologyoverall this project has the ambition to resolve longstanding fundamental questions in immunology to open new avenues for targeting and modulating tcell fates in vivo for efficient vaccine design and for promoting beneficial cytotoxic responses to chronic infections and cancer
detection and global risk assessment of coastal transitional climate and neoclimate regions in a warming world

the most recent report of the ipccar6 indicates that coastal areas are at risk under the climate emergency that the planet faces and now more than ever adaptation is an urgent need although remarkable efforts have been made to quantify future changes in the primary climaterelated drivers of coastal flooding and erosion risk waves sea level rise and storm surges these are not yet fully understood due to the displacement poleward of tropical and extratropical cyclones in a changing climate the ocean waves and total sea levels that they induce could hit regions they did not affect before for the purposes of this proposal these new regions that will be exposed to new weather conditions are called transitional climate regions tcr and neoclimate regions ncr even though these transitional climate regions have been highlighted as critical for ecosystem conservation they are far from being identified and not even close to becoming part of the coastal risk agenda this project aims to detect tcr and ncr in the projected scenario ssp585 by proposing a probabilistic framework of waves and total sea level under prevailing and extreme conditions extratropical and tropical cyclones in coastal areas these regions are prioritized under socioeconomic and ecological criteria for establishing recommendations the project instead of proposing new datasets proposes a cuttingedge spatiotemporal exploration of coastal hazards by using machine learning approaches and a new mindset for climate risk once climate and exposure regions are identified the developing guidelines for coastal risk assessment in these areas will be established
proactive community adaptation to climate change through social transformation and behavioural change

the strategic objective of proclimate is to support communities to proactively adapt to climate change through social transformation and behavioural change to achieve this proclimate will identify social tipping points and policy actions that enable systemic transformation to be achieved across social systems proclimate will adopt an approach guided by the concept of systems thinking which views communities as complex systems that are interconnected and influenced by multiple factors socioeconomic and environmental by understanding and leveraging their dynamics it will then develop strategies and interventions that promote social transformation and behavioural change this will result in a robust framework for designing effective methodologies and tools to foster proactively adaptive behaviours and facilitate transformative changes a set of diverse in terms of climate change problems and socioeconomic contexts case studies across europe will be an instrumental tool for the cocreation validation and upscaling of this framework by running living labs and bringing stakeholders together to understand community governance and institutional structures and to also pilot and validate the projects behaviour change activities the outputs of proclimate will include a the identification of key components of climate adaptation systems their interactions systemic interdependencies and tradeoffs b the design implementation and evaluation of a living lab framework c the identification of social tipping points and leverage actions for policy makers d the development of a multi agent computer model for european socioecological systems to allow a realistic analysis of existing and future policy scenarios likely to produce systemic transformations and e policy recommendations to accelerate systemic change
unlocking de novo rooting potential

plants display an unparalleled regenerative capacity that is widely exploited in modern agriculture where elite genotypes are asexually multiplied through stem cuttings a critical point for this successful propagation entails the development of new roots unfortunately the regenerative potential of plants is not universal as many economically and ecologically important species display poor de novo rooting in my lab we demonstrated that the regenerative potential of plants is the result of a synergistic reaction of two independent wound responses 1 the accumulation of the phytohormone auxin and 2 the transcriptional activation of stem cellinducing transcription factors followup work showed that the latter are specifically activated by pectindependent cell wall changes driving de novo root formation in unropo we will elucidate this process to unlock the rooting potential of poorly regenerating trees to broaden the spectrum of plant species that can be propagated through cuttings through a systematic knockout of pectin modifying and degrading enzymes combined with metabolic profiling we aim to identify woundinduced pectinderived oligogalacturonides ogs that trigger a regeneration response downstream og signaltransducing proteins will be identified through forward genetics experiments and an innovative inhouse developed epitopebased singlecell sequencing method independently we will link the regenerative potential of a collection of 250 poplar trees with their pectin metabolome and use genomewide association studies to pinpoint the underlying pectin modifying degrading and signaling genes ultimately the obtained results will be used to modify in poorly regenerating tree species the genes involved in the production of regenerationcompetent pectin variants their derived woundinduced og and signaling molecules to unlock the de novo rooting potential in such manner contributing to the biodiversity of commercial plantations
green aviation lean arrivals and dynamicity

the galaad green aviation lean arrivals and dynamicity project proposal contributes to the sesar 3 ir aviation green deal topicthe project proposes to develop and validate a concept for dynamic rnp route allocation in the terminal area in order to make atc operations more sustainable resilient responsive and adaptative towards operational condition changes and traffic demand variations the research addresses the development of the endtoend concept including relevant decision support tools evolution and crossborder aspects the idea is to move away from fixed rnp arrival route stuctures towards a flexible approach able to provide agile responses to variations of operational conditions in the terminal area such as traffic density airspace availability or environmentalweather constraints and to develop the best ecofriendly routes structuresas operational improvements the introduction of the galaadproposed concept related to a dynamicity in the use of rnp route structures within the terminal area is expected to provide greater fuel efficiency and environmental sustainability without negatively impacting capacity while improving safety and cost efficiency
fluorescencebased optical phase conjugation through scattering media

generating a complex optical excitation pattern through biological tissue is of great importance for noninvasive biomedical studies however for many biological applications our ability to control light is greatly limited by multiple scattering and physiological motions while optical phase conjugation has potential to overcome these challenges techniques based on fluorescence are still at an immature stage requiring a single isolated guide star exploiting multiple or extended fluorescent guide stars will greatly benefit a wide range of applications such as deep tissue optogenetics because of the availability and targeted labeling of fluorescent probes the goal of this proposal is to achieve active control of light through scattering media using multiple or extended fluorescent guide stars via advanced holographic technique and optical phase conjugation and test its viability for biological tissue
maximising the synergy of european research governance and innovation for climate action

this proposal will address area b of the call maximizing the synergy of climate change research and innovation in europe magica maximizes the synergies between infrastructure investments and initiatives of climate change research and innovation across the european research area era by building upon and further implementing the mission of jpi climate in support to the international and european climate agenda including the european green deal and adaptation strategymagica aims to accelerate the development provision and exchange of knowledge from research and innovation to inform and support policymaking and climate actions via a better coordination of ongoing and future initiatives and a more efficient use of resourcesmagica will be based on a circular and iterative interactions among the strategic scientific and societal components of climate change research and innovation a scientific arena will be created to enhance the debate and discussion within the scientific community on climate ri priorities that will be synthesized in a joint strategic research and innovation agenda on climate change for era 20252034 in addition the creation of a regular forum with european ministries of research and climate and other funding bodies will foster the coordination of the different national research policies in order to meet the erawide priorities and needs identified by the scientific communityfinally a multidirectional dialogue with different relevant social actors from policymakers to the younger generation will be enhanced through different international conferences eg ecca climate neutrality forum workshops and other innovative formats in order to inform citizens but also to detect the social needs concerning the transition to climateneutrality and climate science they will be incorporated into scientific communitys priorities for research thus closing the feedback loop
the first medical device for noninvasive detection and monitoring of infant meningitis

meningitis is a lifethreatening disease that can kill in a matter of hours or cause lifelong disabilities if not detected promptly infants 12 months are the most vulnerable population with a compromised immunologic system although the incidence is relatively low in industrialised countries neonatologists only count with lumbar punctures as the gold standard method to detect the disease being invasive risky and costinefficient neosonics is a patented firstinclass medical device based on highfrequency ultrasound to noninvasively detect and monitor infant meningitis the handheld device is placed on the open fontanelle of a baby and due to proprietary coupling materials and inhouse developed machine learning algorithms detects the level of white blood cells in the cerebrospinal fluid at a sensitivity of 100 with neosonics lps will be limited to only a few patients with infection and no lp contraindication that will be noninvasively assessed with our innovation
excellence in the research area of multifunctional hybrid hydrogelfibrous constructs for wound dressings

hyfidress aims at developing excellence in the research area of multifunctional hybrid hydrogelfibrous constructs for wound dressings this will be achieved by twinning the warsaw university of technology with outstanding eu institutions with high expertise in the areas of novel antimicrobial strategies and electrospinning hyfidress will allow the excellence development required for a consolidated strategic research approach and designing a set of guidelines for the exploitation and commercialization of the results that will have a strong regional national and european impact the proposal integrates synergies in complementary fields of research that include largescale electrospinning technology dualfunction peptide development and microbiology aiming to obtain scientific breakthroughs to improve the global health and economy the objectives of this proposal are in line with the specific challenge and scope of the topic of the twinning bottomup call addressing networking gaps and deficiencies between the research institutions of the widening countries and internationally leading counterparts at eu level this challenge is addressed by twinning wut with leading eu research institutions university hospital regensburg an expert in the development and invention of novel antimicrobial strategies to combat biomaterialassociated infections such as dualfunction peptides and bacteriophages they contribute with their extensive experience on the design and testing of novel antimicrobial agents in vitro and in vivo junia an institution internationallyrecognized for its excellence in the development of functional and instrumented textiles for medical and wellbeing applications providing decisive expertise on lastly bioprex medical bv a biotechnology company that develops antibacterial coatings for medical devices contributes with their expertise from industry ipr protection business development and valorization