Dragon09/odtu_chatbot huggingface dataset:
environmental control of physiology through the braingut axis

a series of tightly controlled processes ensure that energy is either stored or consumed within an organism this control is central to survival and prosperity of the animal yet we only partly understand it communication between the brain and the gut the so called braingut axis has emerged as a key player in regulating aspects of animal physiology by directly affecting energy stores nevertheless due to the astonishing anatomical complexity of the underlying neural circuits in mammals an in depth understanding of the cellular and molecular mechanisms controlling this axis is still lacking using the simpler yet functionally comparable drosophila braingut axis as a model system i have recently shown that adult enteric neurons are functionally plastic this constitutes a physiological feature highly relevant for the adjustment of food intake by the animal to meet energy demands i explored this in females in the context reproduction where mechanisms underlying appetite regulation are evolutionary conserved across multiple species building on my expertise i will now investigate the longstanding question on how environmental factors such as dietary habits or levels of physical activity impact the function of the braingut axis for gutsense i will leverage the unique experimental opportunities available in drosophila to address the role of gutneurons in metabolic adaptation a characterize neurons which respond to these environmental cues and the relevant neural circuits and mediators b identify the target tissues and the nature of interorgan signals involved c investigate the impact of timing and duration of exposure to these factors on metabolic adaptation through these i will uncover basic and likely evolutionary conserved mechanisms and better understand the contextdependent tolerance of metabolic challenges such insight can lead the way in elucidating the contribution of braingut networks to the development of pathophysiology
novel approaches to the quantum bounds to chaos

the recent technological and experimental advances in the field of quantum simulation and computation have led to the renaissance of the study of the dynamics of complex quantum systems different interdisciplinary approaches merging concepts from condensed matter high energy physics and quantum information have emphasised the existence of constraints given by quantum mechanics on the time evolution of correlations and the transport properties the purpose of this proposal is to tackle several outstanding issues at the intersection of these fields from the perspective of standard quantum statistical mechanics the project integrates the applicants expertise in quantum manybody dynamics with the host broad experience in statistical mechanics taking full advantage of the unique multidisciplinary environment provided by the hosting institution the research will be carried out in the perfectly suited environment of the statistical physics group at the laboratoire de physique de lecole normale superieure with prof j kurchan
memory reimagined gender and intersectionality in participatory memory configuration

in the context of the colombian peace process this project undertakes an ethnographic exploration of a communitarian museum developed in cooperation between the colombian national museum and an organization of transgender activists in a marginalized neighbourhood of bogot drawing lessons from this innovative collaboration memoryreimagined investigates the inclusion of gender and intersectionality in participatory initiatives of memory configuration in the outgoing phase of this fellowship the ethnographic examination of this process of configuring participatory memory will explore the intersection of different forms of violence armed structural gendered and postcolonial violence and will delve into the practices of resistance developed by this project in the return phase to the host institution the applicability of the methodology examined in this project in an armed conflictaffected context will be explored in contexts of urban social conflict where intersectional violence and social stigmatization affect the everyday of marginalized populations through the coproduction of knowledge with participants in the project and the development of knowledge exchange with relevant stakeholders memoryreimagined is a form of applied ethnography that foregrounds marginalized memories and contributes to policy and practitioner knowledge of social engagement in memory institutions it further highlights the potential of memory initiatives to transform social inequality and reduce the continuation of entangled forms of violence this project advances the fields of feminist anthropology peace and conflict studies and museum studies nurturing the interdisciplinary field of memory studies the outcomes of this threeyear project will serve as both precedent and toolkit for participatory approaches to memory configuration bringing to european institutions and civil society innovative mechanisms for social inclusion and for the promotion of a culture of peace
off the road the environmental aesthetics of early automobility

in times of climate crisis there is wide agreement that we need a more environmental approach to automobility off the road addresses this challenge by highlighting a largely forgotten fact that automobility was a thoroughly environmental experience before the current system of closed cars on concrete roads emerged this environmental automobility was particularly widespread in the united states where much driving occurred in offroad conditions well into the 1920s motorists navigated through mud sand and water constantly exposed to the elements and acutely aware of their surroundings early automobility thus engendered unprecedented modes of relating to the environmentmodes that have never been systematically researched off the road recovers this environmental automobility by conceiving it as an aesthetic experience one that created new sensual perceptions new strategies of representation and new formations of environmental knowledge these aesthetic patterns found their most complex manifestation in road literature the project assembles researchers from literary studies environmental history and the history of knowledge to recover the aesthetics of environmental automobility in three steps 1 it builds an interactive digital corpus of american road literature from 1890 to 1929 to identify the full range of aesthetic strategies employed to render the experience of environmental automobility 2 it positions these strategies within the modernist aesthetic innovations of the period thus bringing into view a previously marginalized modernism inspired by slow driving in rural environments 3 it examines how the aesthetics of automobility generated a new kind of mobile environmental knowledge that shaped environmental activism and the emergent science of ecology in sum the project reveals how early automobility created distinct modes of environmental awareness that can help us reconceive mobility today
development optimisation and implementation of artificial intelligence methods for real world data analyses in regulatory decisionmaking and health technology assessment along the product lifecycle

realworld evidence derived from realworld data rwd has a promising role to inform regulatory decisionmaking based on highly relevant use cases from regulatory practice and across the product lifecycle real4reg develops aibased datadriven methods and tools for the assessment of medicinal products findings will inform training activities on good practice examples and will be implemented in existing and emerging guidelines for both health regulatory authorities and health technology assessment hta bodies across europe there is urgent need to enable the use and establish the value of the application of rwd across the spectrum of regulatory use cases the use of rwd is established in regulatory processes such as safety monitoring but evidentiary value for further use cases especially in the preauthorisation and evaluation phase of medicinal products is rudimentary the use of rwd in postauthorisation steps is constrained by data variability and by challenges in analysing data from different settings and sources thus the development of new and optimised methods for rwd analyses is essential real4reg addresses the challenges and opportunities of rwd analyses across different health care systems by involving multiple stakeholders to work together in a collaborative approach also outreaching to already established european initiatives our consortium assembles partners with outstanding excellence in the field of rwd analyses including experts from regulatory agencies hta bfarm dkma infarmed academia fraunhofer uef csc au dzne and patient organisations eupals eiwh in an advisory board stakeholders provide input and guidance to the project including patients industry payers hta bodies and healthcare professionals the structure and approach of our project facilitates the successful implementation of the effective use of rwd in regulatory decisionmaking and hta and ultimately supports the application of better medicines for patients
developing and applying a taxonomy of communication behaviours and contextual factors in robotic surgery

robotic surgery is being rapidly and widely incorporated into surgical practice with the current focus of training on equipment mechanics and technical skills the operating theatre setup for robotic surgery is inherently different from the traditional arrangement with the operating surgeon at a console that is remote from the rest of the surgical team and patient the team faces significant challenges due to this physical separation and the visual barrier imposed by the robotic operating equipment as a result leadership and team communication are dynamically altered nonverbal communication and cues need to be replaced by explicit and descriptive communication the overarching aim of my project is to examine what comprises effective communication by robotic surgical teams i will observe verbal communication of surgical teams being trained in robotic surgical skills in a simulated operating theatre in the worldclass rcsi sim i will also interview them about their experiences of effective and ineffective communication in performing robotic surgeries i will develop a taxonomy of communication behaviours and contextual factors that facilitate or inhibit effective communication their descriptions and examples using the taxonomy i will observe live robotic surgeries in rcsi hospitals and code the frequency time and sequence of communication behaviours and contextual factors using an innovative method called event coding the taxonomy from my research will serve as training materials for simulation training focusing on communication for robotic surgical teams and will contribute to the continuous improvement of modern surgery and the quality and safety of patient care with the support of dr claire condron and prof walter eppich this fellowship will help me pursue a successful career as an academic scientist or director of a simulation centre that makes meaningful impacts on the performance and wellbeing of healthcare professionals and patients
boosting ingenium for excellence

the bi4e project is born out from the ingenium alliance of european universities with the ambition of enhancing the existing interuniversity cooperation between the partner universities as well as with other entities both international and local and to strengthen the higher education institutions heis capacity to meet the diverse challenges faced by the higher education system and institutions the twin green and digital transition the fight against climate change the achievement of the agenda 2030 sdgs all of them profound societal challenges the universities must be ready to address the bi4e project intends to give a boost to the alliance making it an effective instrument to promote excellence in the partner heis particularly targeted to the alliance members in the widening countries the gheorghe asachi technical university of iasi and the medical university sofia and involving leading heis from six different member statesthis bi4e project is particularly focusing on the research and innovation missions completing the strategic and operational capacities of the partners especially those from the widening countries bi4e activities will directly touch six out of the seven transformation modules proposed by the policy report towards a 2030 vision on the future of universities in europethe project will improve hei capacity to address major challenges through the implementation of strategic planning adapted to their needs institutional transformation cooperation in terms of research fostering entrepreneurship and the promotion of international scientific careers the project will help to build closer cooperation links between the partners that will facilitate the exchange of information knowledge and experience at the end of the project the alliance will be much more prepared to become a fully operational european university alliance in which cooperation in education and research will be carried out seamlessly
sustainable preservation of underwater archaeological sites a novel approach to cultural heritage management

cultural heritage is the legacy of tangible intangible and natural heritage assets of a society that is inherited from past generations preserving the remains of the past for the benefit of future generations is common in international heritage policy current management practice advocates preserving underwater cultural heritage uch where it lies on the seabed in situ however this practice is questioned due to a lack of understanding of the entangled threats posed by multiple natural and anthropogenic drivers in a rapidly changing ocean environment and increasing human exploitation of the marine environment it is necessary to develop new concepts for assessing and preserving this resource with over 3000000 shipwrecks and thousands of submerged prehistoric sites lying on the floors of the worlds oceans endure aims to disentangle both natural and anthropogenic decay processes determine their cumulative and interactive effects on uch and proposes a novel conceptual framework to preserve this heritage based on site entropy this will be achieved by 1 detect visualise and interpret the products of natural and anthropogenic decay of shipwrecks and submerged prehistoric sites using marine remote sensing techniques integrated with natural and anthropogenic variables in a gis platform 2 determine key natural processes and rates of decay of archaeological materials in situ and in the laboratory 3 remotely identify and rank simultaneous decay processes including increasing threats to hidden and largely inaccessible heritage sites using ecosystem modelling and 4 propose novel intervention methods to mitigate threats to uch and where not possible strategies for curated decay ultimately endures holistic structured framework can be synergistically integrated and implemented by stakeholders and marine practitioners for a sustainable preservation of the marine environment and the worlds underwater cultural legacy for future generations
rust and revolution understanding social technologies in enlightenment europe through metaphorology

this project asks how if we take rust with its connotations of change and corruption as a starting point we can return to three very different clusters of phenomena each of which has been called a revolution the chemical the french and the industrial to understand how texts implicated in each interact not only do such texts exchange metaphors which structure thought and concept
parameterized complexity through the lens of path problems

nowadays numerous problems are known to be nphard and hence unlikely to admit worstcase efficient algorithms fortunately the field of parameterized complexity pc shows that the nutshell of hardness often lies in particular properties called parameters of the instances here we answer the fundamental question what makes an nphard problem hard specifically how do different parameters of an nphard problem relate to its inherent difficulty based on this knowledge we design efficient algorithms for wideclasses of instances of nphard problems at the heart of pc lies the study of path or cycle problems the inception of pc was inspired by the graph minors theory where the resolution of disjoint paths is a cornerstone moreover the study of kpath has led to a large number of major breakthroughs in pc over the past three decades still i fundamental questions concerning path problems have remained unanswered and ii close to nothing is known about the relations between the different techniques to solve path problems the overarching goal of this proposal is to build a unified deep theory to analyze parameterized path problems as known techniques to solve path problems rely individually on graph minors theory extremal combinatorics matroid theory exterior algebra and more i will draw new deep connections between these fields towards unification based on the new theory i believe that i will be able to answer decadesold questions in pc which will revolutionize the power of this field this includes the establishment of an efficient graph minors theory an optimality program for colorcodingamenable problems and a machinery to refute the existence of polynomial turing kernels answers to these questions will substantially reshape the future of the design of parameterized algorithms graph algorithms and preprocessing procedures additionally they will have high impact applications in practice
a siopen pragmatic clinical trial to monitor neuroblastoma relapse with liquid biopsy sensitive analysis

highrisk neuroblastoma accounts for 15 of cancer relateddeaths in children half of the 1500 patients yearly diagnosed with neuroblastoma in the eu have highrisk disease which will relapse or progress in half these cases after firstline treatment relapsed neuroblastoma is aggressive and often therapyresistant monitoring for disease relapse and therapy response is crucial for the survival chance of these patients the current standardofcare for monitoring are imaging technologies and bone marrow assessment which are costly invasive and a burden for children who often require anesthesia these drawbacks limit how often is monitored more sensitive less invasive and less toxic monitoring techniques are needed the mutational spectrum often changes in recurring tumors which may explain therapy resistance and provide additional druggable targets imaging however provides no information about molecular characteristics liquid biopsy tests are minimally invasive allow frequent sampling and sensitively detect tumor molecular markers in tumorderived dna and messenger rna circulating in peripheral blood monalisa aims to close existing gaps and establish liquid biopsies as standardofcare to monitor relapsedrefractory neuroblastoma as a blueprint for other pediatric cancers reliable early assessment of molecular progression or relapse is the main aim of the pragmatic randomized clinical trial proposed in monalisa we develop a digital decision support tool to help oncologists use the new monitoring and apply patientreported outcomes to integrate patient viewpoints and assess the effect of minimally invasive liquid biopsy diagnostics on quality of life we will establish whether events can be detected earlier using liquid biopsy monitoring and whether better overall survival is enabled by earlier diagnosis and treatment interventions this essential step towards personalized medicine will support reliable disease monitoring under treatment this action is part of the cancer mission cluster of projects on diagnostics and treatment diagnostics
climate policy vs economic growth opinions models and novel strategies

climate change has revived the debate on growthvsenvironment which may intensify in coming years this project studies to what extent concerns about economic growth ranging from pro to antigrowth hamper socialpolitical support for ambitious climate policy and how this can be amended using surveys experiments and interviews it assesses whether beliefs about growthvsenvironment affect policy opinions of distinct stakeholders voters policymakers journalists etc and if this is moderated by preferences regarding instrument types such as standards taxes or subsidies the project further tests the role of information by comparing the effect of distinct beyondgdp metrics on views about growth vs climate policy in addition it studies how growth concerns relate to the design of pledges in the paris agreement as these demarcate national climate policiesbased on collected data and derived insights the project then undertakes systemdynamics and agentbased modelling to study the codynamics of climatepolicy design and support this will create models of the dynamic policysupport cycle dpsc comprising policy design economic and emission impacts opinion dynamics ie supportresistance and policy adaptation it involves comparing growth strategies and climate policies using distinct beyondgdp metrics and connecting this to stakeholder opinion dynamics informed by the model results in a third part the project explores whether an agrowth strategy which is precautious towards both economic and climate risks can increase support for ambitious climate policy given stakeholder diversity we perform interviews to decide about tailored strategies in this respect similar proposals to agrowth notably under the label of postgrowth will be examined as well the ultimate aim is to learn about dynamic packages with climatepolicy instruments and apostgrowth measures that culminate in majority support for ambitious climate policy
crop responsive greenhouse agrivoltaics system with co2 enrichment for higher yields

regace will develop and validate a disruptive radical innovative technology that will make agrivoltaics a major contributor to the eu clean energy portfolio the technology is highly competitive compared to other solutions because it fully addresses the desired destination impact of clear affordable energy with a projected installed cost for customer of 600 per kilowatt compared to 880 for ground based photovoltaic fields furthermore the system demonstrated in this project is also cost effective in areas with less sunshine which currently are outside areas for which agrivoltaics could be considered the core technology is a responsive tracking system mounted in the greenhouse driven by a plc controller that changes the angle of the tracking system according to the plants needs we will test a system using co2 enrichment as a means to increase electricity production in low light conditions by increasing the angle of incidence of the bifacial panels in the tracking system the tracking system is hung with a few screws from the supports of the greenhouse removing the need for windproof supports reducing the price per installed kilowatt thus this technology allows not only for the dual use of land but also for the dual use of infrastructure the design of the technology also leads to reduced construction and maintenance costs duration of execution and moreover through reduction of co2 emissions in addition to the economic impact this will also lead to significant positive effect on ecologicalenvironmental sustainability and reduced ecological footprint through its lifespan maintenance and operation it will also lead to the diversification of the energy producing market with small holding greenhouse owners playing a significant part in the market the technology will be tested in operational industrial environments in six locations with different greenhouse types and crops