Dragon09/odtu_chatbot huggingface dataset:
multifunctional microfluidic patch for infectious diseases diagnosis

in vitro diagnostic ivd technologies have revolutionized healthcare yet remain confined to the laboratories as witnessed during the covid19 pandemic this traditional centralized approach was not sufficient to prevent and manage viral outbreak because it massively failed to deliver quick and costeffective diagnosis the ongoing pandemic further emphasizes the growing need to urgently bring labquality diagnosis to the hands of end users ie pointofcare poc despite high expectations from labonchip technologies they failed so far to disrupt the ivd market due to their complexity of integrationoperation high cost offchip sample preparation poor scalability to mention only a few the fortifiedx consortium aims to revolutionize the poc ivd field by making use of novel multifunctional biocompatible polymers and their microstructuring with mass fabrication technology to develop for the first time a true sampletoresult poc test we will develop a fortifiedx microfluidicbased patch capable of both biofluids selfsampling via hollow microneedles and immediate analysis of this sample on the very same patch in a completely selfpowered manner two unmet clinical needs posing epidemicpandemic treats to both the developed and developing world are selected 1 sexually transmitted diseases in particular simultaneous diagnosis of hiv and syphilis to enable timely diagnosis of patients not always able to reach centralized settings due to stigma or financial difficulties and 2 viral haemorrhagic fever in particular ebola and lassa viruses to battle their highly contagious and deadly outbreaks to tackle this challenging aim the interdisciplinary and experienced fortifiedx consortium 2 universities 5 research institutes and 2 smes from 6 countries will combine insights from material science engineering and microfabrication microfluidic technology development bioassay development clinical validation and life cycle assessment
supramolecular biomimetic and electroconductive hydrogels heterochiral tripeptides and branched carbon nanotubes join forces to repair heart

cardiovascular diseases including ischemic heart disease are the leading cause of death in europe cardiac tissue that has been lost by injury cannot be naturally regenerated which leads to heart failure to help repair heart biomaterialsdriven approaches especially hydrogels in combination with carbon nanotubes cnts are among the most promising strategies however existing cnt based hydrogels provide a simplistic reflection of structural and functional features of the native cardiac tissue a solution lies in mimicking the native tissue from multiple angles bioadhesion viscoelasticity mechanical properties electroconductivity 3d supramolecular and hierarchically ordered fibrous structuresuprabioelectris aims to develop novel supramolecular biomimetic and electroconductive nanocomposite hydrogels by exploiting the concept of branching widely occurring in nature the key players in this project are thus branched cnts and supramolecular biomimetic short peptidesbased hydrogels the union of these contrasting components constitutes an innovative approach making use of their strengths to reach the required multifaceted biomimicry the hypothesis is that the combination of these components will create smart and multifunctional biomaterials able to boost and support electrical activity of cardiomyocytes and thus aid in heart repair furthermore advanced stateoftheart material characterization tools will be used to study nanocomposites with nanoscale spatial resolution ensuring optimal material design and functionsuprabioelectris project therefore addresses one of the major health challenges and will highlight the importance of using supramolecular structures in the design of biomimetic materials the project is highly interdisciplinary and international it will also shape the researcher into a leading expert in hydrogels by expanding his existing expertise via tailored training and acquisition of new skills
food storage in the late fifth fourth and third millennia bc in the northern fertile crescent

foodstore investigates food storage systems in the northern fertile crescent western inner syria south eastern turkey northern iraq during the late fifth fourth and third millennia bc in order to define the relationship between storage practices socioeconomic complexity and ecological conditions during these millennia the area experienced different trajectories leading to the emergence of complex societies and the storage of food staples was central to these developments the project has a multilevel design that combines the collection of published data with the direct study of storage facilities from key archaeological sites these features will be investigated through a combination of traditional macroarchaeological methods with microarchaeological techniques from applied geological chemical and biological disciplines microstratigraphy fourier transform infrared spectroscopy and phytolith analysis key objectives for foodstore are the establishment of a robust analytical protocol to investigate food storage practices in archaeological contexts to develop an interdisciplinary framework to tackle issues connected to food preservation to contribute to the collaboration between archaeology anthropology and natural sciences and to enhance the relevance of archaeology to support traditional rural heritage and food management practices
drivers and brakes of car t cell efficacy determined by the tumor immune microenvironment

cancer immunotherapies with chimeric antigen receptor car t cells have shown dramatic clinical efficacy in patients with b cell neoplasms thus their clinical use is expected to increase considerably in the near future however for poorly understood reasons not all patients with lymphoma benefit from these expensive therapies the ability to stratify patients into probable responders vs nonresponders prior to immunotherapy will improve treatment efficacy limit patient exposure to adverse effects and mitigate the significant economic costs associated with these therapieswe and others have previously demonstrated that effective antitumoral immunity requires complex spatially coordinated interactions between different cellular elements within the tumor immune microenvironment time there is evidence that patient response to immunotherapy is attributed to specific characteristics of the time such as the composition spatial arrangement and activation states of immune cell types in it therefore a better understanding of the time and of how immunotherapies come into effect in live intact human tissues is critical for the selection of successful immunotherapies for our patientsthe overarching aim of the cartime project is to explore and visualize the cellular and molecular mechanisms of car t cell efficacy in lymphoma determined by car t cell interactions with the time this shall be achieved by creating a highdimensional map of the time of diffuse large b cell lymphoma performing live tissue cultures treated with immunotherapies and establishing a novel live cell microscopy platform to interrogate intact human lymphoma tissue treated with car t cells drug perturbations multidimensional imaging technologies rna sequencing and integrative bioinformatics analysis will illuminate mechanisms of therapy response vs resistance reveal novel predictive biomarkers and inform future combination immunotherapy strategies to improve patient outcomes
boosting water depollution development of a novel hybrid photocatalytic membrane for removal of contaminants of emerging concern

emerging pollutants including pharmaceuticals and endocrinedisrupting compounds are drawing serious global attention due to their persistent nature in the environment and potential health implications to address these challenges i havehycem is centered on the development of an innovative zscheme photocatalytic membrane optimized for the degradation of contaminants of emerging concern cec in water furthermore this project aims to improve the heterojunction structure by applying surface engineering which results in dendritic morphology and unique electron transfer channels by harnessing a hybrid system of degradation and separation by developing a metalorganic framework mof photocatalytic heterojunction immobilized on a pdot membrane with the epitaxial growth method hycem will overcome challenges related to low photoactivation rapid charge recombination limited surface area and stabilityemerging pollutants including pharmaceuticals and endocrinedisrupting compounds edcs are drawing global attention due to their persistent nature and potential health implications addressing this the integrated hycem system not only promises effective cec degradation but also eliminates intermediate byproductsmitigating secondary pollution optimizing photocatalyst reuse and coping with the challenges of the commercial applicationa pioneering facet of hycem is its ability to utilize visible light for degradation offering an environmentally friendly alternative to the conventional energyintensive uv light methods additionally this project will enrich our knowledge on cec degradation pathways presenting invaluable data for future chemical oxidative treatmentsbeyond the technical advancements hycem also emphasizes my training enhancing my skills in diverse aspects of management and leadership to a high level ensuring i gain both specialized knowledge in the field and broader competencies that will significantly improve my professional development
innovating in smart programmable integrated photonics

ipronics has pioneered field programmable photonic gate arrays fppga an entirely new class of powerful flexible photonic processors for computing applications in the optical sphere unlike electronic fpgas they use optical interference to perform very highspeed analog operations this delivers major increases in system performance and reduced power consumption our project inspire innovating in smart programmable integrated photonics will make fppga programmable photonics available in form of trl56 demonstrators for the first time inspire will advance our current technology readiness by increasing the number of programmable unit cells per chip and improving key performance characteristics including power consumption space requirements and chip coupling losses this new optical layer design is then produced in a pilot batch ready for functional tests validation and demonstration we will concurrently develop the complementary electronics and software needed to drive monitor and program this newly developed fieldprogrammable photonic gate arrays fppgas and involve early adopters to ensure our target specification meet market requirements we will validate the potential of programmable photonics in form of three prototypes ready for demonstration 1 a generalpurpose starter kit suitable for education rd and simple applications 2 a rfphotonics demonstrator designed to accelerate waveform processing in mobile communication networks and 3 a photonic computing demonstrator that will speed up data centre operations we will advance beyond the current trl4brl3 to at least trl6brl5 by validating and demonstrating the newly developed solution with pilot users from selected verticals the results will be used to update our business case refine our business model and prepare for scaleup and market entry in a followon project
endoplasmic reticulummitochondria contact sites structural and functional adaptation during insulin resistance

the high calory intake and the sedentary behaviours represent one of the most common stress to which humanity is subjected this is leading to an increased incidence of obesity that can be aggravated by dysfunctional metabolism among which insulin resistance ir is the most common scenario two crucial processes know to lead to ir are endoplasmic reticulum er stress and mitochondrial dysfunction mitochondria and er are in tight physical contact through the mitochondriaassociated er membranes mams which are emerging as an important hub for glucose homeostasis mams are involved in a plethora of cell functions such as lipid synthesis ros and ca2 signalling autophagy and inflammation all processes tightly linked with cellular insulin sensitivity in support to this notion mams miscommunication was shown to occur in the presence of ir nevertheless no conclusive molecular mechanisms can explain mams adaptation during ir furthermore how mams remodelling affects the signalling between er and mitochondria ca2 ros lipid exchange during ir progression and how this affects er and mitochondria functions are still open questions the overarching aim of this proposal is to characterize the alterations of intracellular signalling in mouse models of hepatic ir at the level of mams and to develop a standardized methodological approach to assess interorganelles signalling changes during pathophysiological cues to this goal i will implement innovative approaches in vivo to quantify these contacts and to identify the mams molecular composition during ir furthermore i will characterize the consequence of ir on mams signalling pathways by combining omics approaches and imaging technics to identify the molecular and functional signature of the mams during the ir in vivo and characterize new molecular pathways involved in the onset of ir in the liver
functional impact of the psychiatric risk gene cacna1c in human ipscderived microglia

psychiatric disorders such as major depression bipolar disorder schizophrenia and autism are highly prevalent chronic diseases however their underlying pathophysiology is still largely unknown genomic studies have identified single nucleotide polymorphisms snps in the cacna1c gene that are robustly associated with all of these major psychoses among these is the main noncoding risk snp rs1006737 beyond that a gainoffunction mutation in cacna1c has been described which causes a multiorgan phenotype including severe cardiac arrhythmias immune deficiency cognitive abnormalities and autism named timothy syndrome ts immune alterations plus the involvement of their primary mediators in the brain the microglia have also been reported for psychiatric disorders based on this we aim to introduce the risk aallele of the cacna1c snp rs1006737 as well as the ts mutation g406r into human ipsc control lines using crispr base editing the generated isogenic lines are then differentiated into ipscderived microglia cells imgs and undergo a systematic functional characterization including the analysis of transcriptomic profile intracellular calcium levels motility phagocytic activity cytokine release cellular bioenergetics and mitochondrial parameters furthermore the newly created img cultures are tested in brain organoid systems to assess their effects on neuronal activity and function via multielectrode array recordings and single nuclei sequencing the obtained results will contribute significantly to elucidating whether microglial function is causally affected by the selected cacna1c risk variants what underlying checkpoint mechanisms are involved and whether these changes compromise microglianeuron interactions thereby impairing neuronal activity and function overall this study will add to a better understanding of the role microglia play in the pathogenesis andor progression of cacna1cassociated psychiatric disorders
photonics on germanium new industrial consortium

the project scope is to develop an innovative technology of germanium gebased vcsel the main objective is to develop a gevcsel epigrowth by mocvd and mbe techniques and processing of high performance and reliable lasers to be integrated in 3d camera and lidar demonstrators the key challenge is to achieve high crystal quality of grown layers while taking the advantage of a better crystallographic lattice sameness between ge and al gallium arsenide gaas which enables to decrease misfit defects density and in consequence to increase the quantum efficiency of the device several characterisation methods will be used as xray diffraction and topography depth high resolution sims electron microscopy semtem atomic force microscopy reflectance pl mapping and others each growing campaign will be concluded by processing of conventional vcsels gaasbased and vcsels on ge which will allow the verification of vcsels parameters and comparison of both type devices the vcsel technology drives a dynamic market with constant need for innovative solutions demonstration of high performing devices of geonsi can unlock potentially large markets from optical data communications to imaging lighting and displays to the manufacturing sector to life sciences health care security and safety in commercial applications the performance costs and the strong reduction of toxic elements will be very important factors to drive a replacement of the current technology the ge offering a higher yield and less production losses due to higher uniformity at larger size wafer is promised to lower the environmental burden compared to expensive gaas substrate as the vcsel sector is developing dynamically with laser production expected to triple in the next five years the project with its innovative gevcsel solution has the potential to significantly contribute to the reduction of lasers global usage of toxic materials and improve the device performances
a global as well as local flexibility marketplace to demonstrate grid balancing mechanisms through crosssectoral interconnected and integrated energy ecosystems enabling automatic flexibility trading

the main objective of glocalflex is to mobilise demandresponse solutions services in replicated manner for prompt horizontal scaling of flexible local energy systems les by means of easy access and low barrier energy flexibility markets to increase the participation of the consumers across all energysectors the glocalflex approach promotes viable interoperable solutions and products at all levels of the grid consumers producers retailers aggregators market by selecting modular standards and tools during development it allows the overall system of systems to be 1 flexible by means of energy use to provide quality services to grid and 2 flexible by means of its own evolution to change upgrade or integrate several appliances consumers and microgrids to create complex but viable crosssectoral energy ecosystemsthe glocalflex concept will allow any local energy system les positive energy districtped community or appliance to evolve in a consistent way and offer flexibility using suitable hardware addons in a costeffective and systematic manner to expose their full flexible potential glocalflex concept can adopt to any les size availability of local resources and regulations this project will demonstrate near real time large scale flexibility trading in six different field locations in europe it has consumer and system centric pilots that develop flexibility services and replicate them within the pilot group the glocalflex aims to have completely automated machinetomachine flexibility trading and flexibility order execution in les by means of open interoperable energy flexibility market and open standard based ittools that allows more flexibility consumers to join the market therefore glocalflex will push forward the overall integration of disruptive renewable technologies and enhancing the stability of the grid at the same time
probabilistic formal verification for provably trustworthy ai

this project is concerned with the formal verification of modern artificial intelligence ai systems with machine learning ml components certifying that an ai satisfies certain requirements such as fairness or safety standards is pivotal for the regulation and use of this technology in many domains especially those with high socioeconomical stakes techniques that can provide formal guarantees on modern ai will have broad impacts on multiple areas described in the horizon europe strategic plan 20212024 the proposed framework goes beyond the stateoftheart by adopting a probabilistic approach that satisfies three desiderata first it supports arbitrarily complex distributions handling uncertainty over both nondeterministic systems andor complex multidimensional enviroments second it unifies under the same formalism the verification of a multitude of ml models and properties of interest third it enables the verification of ml models as part of a larger system and promises an easier integration into the existing probabilistic formal verification pfv tools the approach is based on the notion of weighted model integration a recent formalism that enable probabilistic inference over arbitrary combination of logical theories and algebraic constraintspaolo morettin is one of the most prolific authors in the novel but vibrant field of wmi having both industrial experience in formal verification and a mloriented scientific background he is the ideal candidate for pushing the boundaries of wmibased probabilistic formal verification as a msca postdoctoral fellow paolo morettin will advance the stateoftheart with both theoretical and technological contributions with the ultimate goal of enabling and facilitating the integration of the proposed framework into the existing pfv tools at the same time he will develop a highly valuable multidisciplinary mlfv background enhancing his career perspectives
towards artificial human embryoid models engineered and synthetic platforms for ex utero mammalian embryogenesis

studying early human development is crucial for understanding embryonic defects and learning developmental principles that can be applied in differentiation of human ipscs into relevant cells for transplantation such research requires large numbers of human embryos however justified ethical barriers makes this impossible since the mouse has been a guiding compass for all revolutionary technologies applied with human pluripotent stem cells here we seek to develop biotechnologies in mice rabbits and nonhuman primates nhp that will likely enable in the future conceptually and technologically circumventing this problem in humans a twopronged biotechnological platform development will be pursued 1engineering devices that enable ex utero culture of mammalian embryos from preimplantation until complete organogenesis 2establishing platforms in which in vitro expanded stem cells can be coaxed to generate synthetic embryolike structures embryoids that can selforganize and be grown in the latter developed ex utero embryogenesis devices to yield structures with both embryonic and extraembryonic compartments that capture advanced embryonic patterns motivated by our recently devised platform that allows natural mouse embryogenesis from postimplantation until organogenesis ex utero we now aim to develop and validate biotechnological platforms that capture entire stages of development from preimplantation until completion of organogenesis in natural mouse and rabbit embryos ex utero and transform this knowledge to engineer advanced synthetic embryoids from in vitro expanded mouse rabbit and nhp stem cell populations we will utilize inhouse engineered devices stem cellbased models cuttingedge gene editing microscopy optogenetics and single cell biology our work will establish novel platforms for generating advanced selforganizing embryoids ex utero that can be used for stem cell differentiation drug screening and disease modeling