Dragon09/odtu_chatbot huggingface dataset:
elucidating the networks of immune stromal connections by perturbation of immunity in cancer towards developing novel therapeutic strategies

immune cells monitor and eliminate cancer cells and thus keep tumors in check along the lifespan of an organism however tumors have evolved various mechanisms to avoid immune surveillance therefore understanding these mechanisms and interfering with them to facilitate immune cell eradication of tumor cells is the focus of many successful immunotherapies however the efficacy of immunotherapy is limited to only a small fraction of patients and only certain types of cancers therefore it is crucial to understand the immunetumor interactions to develop new treatments moreover tumor evasion mechanisms interfere with such treatments as compensatory programs ensue soon after therapeutic intervention these compensatory programs are not limited to tumor cells but also occur in the stromal compartment of the tumor microenvironment tme which provides indispensable support to the tumor and is often overlooked as potential target for intervention here we aim to gain a fundamental understanding of all cellular networks within the tme to elucidate the roles and programs carried out by each cellular element participating in the complex multilevel interactions that occur before therapeutic intervention and afterward toward this goal we will map the entire spectrum of immune and stromal cell interactions in the tme we will identify negative and positivetumorregulator dependent programs primary and compensatory unique and sharedacross pathogenic conditions and cellintrinsic and extrinsic programs aim 1 additionally we aim to identify conserved mouse and human pathways using a parallel mouse and human tumor slice culture system aim 2 based on aims 1 and 2 we will test and validate new candidates for targeted rational combination therapy invivo aim 3 our findings will lay the foundations for a fundamental understanding of tumor immunity dynamics in the tme and create a paradigm shift in immunotherapy
linking intestinal bacteria and host metabolism to tackle type 2 diabetes with novel food

poor nutritional regimes are main drivers of metabolic diseases and intestinal dysbiosis type 2 diabetes t2d prevalence is expected to reach 7 of the global population by 2023 and to curb its rise is an urgent public health need intestinal dysbiosis is a determinant factor in the progression of insulin resistance to t2d shifting host metabolism though undefined mechanisms whose understanding would be crucial to allow personalized interventions advances have been limited by microbiome complexity and interindividual variance diban binds together the necessary combination of expertise to address this question based on the concept that the initial driver of the nutritional effects is the metabolic shift that takes place in the intestinal bacteria which is transduced to the host in this context technological breakthrough tools for novel food development that ensure the promotion of a healthy microbiomehost metabolic interface are an urgent need to prevent dysbiosis and t2d diban will overcome current limitations in nutrienttesting by developing advanced exvivo platforms that fully recapitulate the in vivo setting of dysbiosis and insulin resistance that will be validated with in vivo omic data to warrantee the health promoting effects of novel foods we will test a new concept in the emerging field of insect food technology that an adequate insects metabolicintestinal health ensures the healthy properties of its derived products the validation of this idea will also serve to identify biomarkers for the monitorization of the insects health status a domesticus will be the testing model of choice due to its excellent nutritional profile that will be boosted by complementing the insects diet with microalgae bioactiverich extracts all these data will be integrated for the design of a pilot artificial intelligence aibased application for the prediction of personalized responses to nutritional interventions
nearfield enhanced accuracy tracking for 6g networks

as the technological world marches ahead the advent of the sixth generation 6g networks promises unprecedented advancements in communication capabilities one of the core components of 6g systems will be the inclusion of various large array structures such as the extremely large antenna array reconfigurable intelligent surface and cellfree multipleinput multipleoutput ttraditional positioning and tracking methodologies which are based on farfield signal models are illsuited for these innovations this is mainly caused by curved wavefront in the nearfield models consequently the conventional methods for positioning both passive objects eg walls and active users eg phones will be severely degraded when the farfield assumption does not hold on the other hand the radio signals optimized for positioning and sensing in the farfield are suboptimal in the nearfield regime to address this gap this research aims to develop novel positioning and tracking methods tailored explicitly for the nearfield environment of these large array structures to this end three work packages wp are conducted wp1 is to design optimal signal waveforms for positioning and sensing with large andor sparse antenna arrays that can make full use of the nearfield features wp2 is to develop phasecoherent sensing and tracking methods for nonisotropic and extended targets wp3 is to develop algorithms for carrierphase based positioning and tracking of active targets by using the nearfield signals transmitted by them this research intends to solve these challenges through the development and implementation of innovative algorithms and methodologies such as compressive sensing convex or nonconvex optimization and machine learning establishing a dedicated framework for nearfield positioning and tracking in 6g networks
initiative to support promote and integrate researchers at risk in europe plus

inspireurope will strengthen and coordinate support in europe for researchers at risk building on the work undertaken by inspireurope launched under msca in 2019 inspireurope proceeds from the view that excellence in research depends upon free and open scientific debate and requires a diversity of perspectives and methodologies to flourish the need to expand support for researchers at risk is urgent and the value of a coordinated effort across countries and institutions that is dedicated to providing support for researchers at risk has never been clearer researchers at risk are scholars scientists and researchers who face threats to their life liberty or research careers including those who have been displaced because of such threats persecution harassment intimidation and violence directed at scholars scientists and researchers not only place individual lives and careers in jeopardy such threats and abuses also put the very future of research at stake inspireurope will combine forces across national and institutional boundaries to respond through guidance training and consultations with over 300 researchers at risk inspireurope will help to build up the skills and knowledge needed to facilitate access to european national and institutional funding and support through guidance and advice for over 400 employers in the academic and nonacademic sectors inspireurope will increase institutional capacity and preparedness to support researchers at risk through policy input to the national and european levels inspireurope will facilitate and encourage the development of new support programmes and improve the policy environment in europe for researchers at risk project partners will leverage their vast networks to bring project outputs to over 30000 people in more than 100 countries inspireurope will consolidate diversify and multiply efforts to improve lives and career opportunities together with researchers at risk
personalized sustainable smart patch omnificence

today the main research trends in decentralized personal health monitoring pdhm are on monitoring at longer periods reducing motion artefacts and multimodal monitoring persimmon will push the stateoftheart by providing personalized and biodegradable multimodal smart sensor patches based on lowcost additive manufacturing the innovations introduced by persimmon rely on new sensor materials ai and digital surface mount technology smt the developed patches will be used in multinodal networks with multimodal nodes on the skin for advanced dphm with improved sustainability and circularity cloudbased ai sensor fusion will be used for blood pressure and body temperature monitoring and edgeai for reducing motion artefacts selecting good signal conditions and reduce power consumption at the smart patch in addition persimmon will develop new sensor materials for biodegradability sensor electrodes and nanomos embedded in semipermeable materials that will allow gas sensors on the skin with both extended lifetime in multiuse modules and at extreme low cost in disposables within 48 months and with the involvement of 13 partners from six countries persimmon will demonstrate remote dphm in sport use cases of ski mountaineering and swimming and in continuous remote monitoring of chronically ill patients in their everyday lives a production line for additive manufacturing of soft and compliant printed wiring boards based on digital smt manufacturing and a 5g gateway for body worn iot will be demonstrated and made as business cases the used watersoluble biopolymers and liquid metal interconnects and contacts remove microplastics waste and allow for reuse of clean components and recycled metal without hightemperature or toxic processing life cycle analysis societal uptake acceptance and compliance to a circular economy are indeed at the methodological basis of the design and development of new devices and of the appliance tests in persimmon
taxable anonymous libre electronic reserves

taler will roll out a new electronic payment system that benefits european citizens merchants and banksgnu taler is a privacypreserving digital payment system developed bythe gnu community and taler systems sa with additional funding fromvarious ngi calls ngi0 pet ngi0 entrust ngi pointer ngi trustgnu taler offers privacy for the buyer while enforcingtransparency on sellers as a result citizens do not suffer fromsurveillance when paying with gnu taler and states canensure that businesses can be held accountable for theirincome and pay their taxesthe first vertical addressed by taler is the financial industrytaler will bring gnu taler to trl 9 by making gnu taler available as paymentsystem via retail banks via gls and magnet banktaler counts three verticals for its gotomarket strategy the first is thepublishing sector independent book publishers and journalistswill integrate the sector with gnu taler as a viable payment system the ehealth sector will implement gnu taler as payment option for ehealth providers to guaranteeprivacy of the payer finally the floss ict supply chain vertical will integrate gnu taler in the floss development ecosystem for donations and pledgeswe expect taler to have several long lasting impactsby providing micro payments at very low overhead gnu taler permitsinternet business models to shift away fromadvertising revenue or subscription models especially for onlinepublishers the norisk transactions will lower transaction fees and open online paymentsfor the underbanked population and citizens marginalized from digitalisationfinallyeasy to use efficient and privacyrespecting commercial payments willlikely impact the debate on central bank digital currencies cbdcssuch as the digital euro as central banks globally struggle topresent a compelling usecase for their retail cbdc projects
birth of the marimacho modernismos trans cultural productions in latin america

birth of the marimacho modernismos trans cultural productions in latin america analyzes the emergence of a new gender expression in earlytwentiethcentury latin american literature science and visual culture the marimacho in the hispanic tradition marimacho is the umbrella notion that may refer to a sexist slur as much as a modern form of nonbinary gender a transmasculine identification or a lesbian identity this project examines the aesthetic construction of this hybrid countercultural and genderdissident figure in an extensive cultural repertoire that includes novels plays films leaflets medical studies prison and mental hospital records poems and newspaper and tabloid articles i seek to increase the understanding of the regions politics of gender and sexuality during the modernizing era 1880s1930s that is before the solidification of lgbtq activism pride literature and minority social movements of the global 1960s in response to the new gender dynamics led by cosmopolitan networks of firstwave feminism the keepers of gender normativity created the marimacho as a monstrous version of conventional masculinity the main objective of this research is to investigate why a broad range of cultural materials named queer women nonbinary individuals and trans men as marimachos as gender hackers that put at stake the futures of heteronormativity reproduction and family life
diversity outdoors embodied ethnoracial inequalities and outdoor recreation in europe

this project seeks to investigate how social inequalities are embodied through a comparative analysis of participation in outdoor recreation in europe outdoor recreation such as hiking climbing swimming but also birdwatching and camping is as a pivotal arena where racialized encounters and practices manifest given the current international attention to diversity and lack of antiracism in europe on the one hand and the understudied emerging grassroots outdoor movements that challenge these discourses on the other it is essential that we better understand the embodiment of ethnoracial inequality and its intersections with religion gender class and ability this project undertakes a comparative ethnographic study of ethnoracial embodiment in outdoor recreation in westerneurope while asking the questions what are the effects of ethnoracial embodiment on sociocultural diversity in outdoor recreation how are bodies constituted as in or out of place in outdoor recreation in europe how is diversity in outdoor recreation influenced by local national and transnational discourses and imaginations what is the role of ethnoracial affinity and opposition in experiences of participating in and contesting the status quo of outdoor recreationthe central objective is to gain insight in the commonalities and sociocultural distinctiveness of how ethnoracial inequalities are embodied experienced and contested across europe it does so by analysing the embodied sensorial dimensions of racialization and its intersections in outdoor recreation and developing a theorization on ethnoracial embodiment the concept sensory ecology helps innovatively analyse identitybased outdoor groups and activities outdoor recreation policies and discourses between local movements national level organizations and online communities the project compares three countries with emerging identitybased outdoor groups the netherlands germany and the united kingdom
unveiling earths critical resources for clean energy and a sustainable future

the coming decade will be a defining test for humanity and its capacity to respond to unprecedented global challenges to meet the demands from the energy transition and related green technologies the current global supply of critical minerals will have to quadruple by the end of 2040 likewise the eu2030 goal to create a more resilient energy plan with minimum dependency on fossil fuels creates an enormous demand for alternative greener and sustainable energy sources among these deep geothermal energy has the highest potential for longterm largescale supply of energy for heating and generation of electrical power in response to these pressing needs the earthsafe doctoral network will develop an innovative and efficient datafusion paradigm to enhance the effectiveness of exploration efforts for deep geothermal resources and critical materials robust to data missing limitations earthsafe will achieve this ambitious goal by harnessing i the complementary strengths of multiple satellite and landacquired datasets and ii a novel combination of artificial intelligence probabilistic inverse theory computer modelling and science communication holistic training of early stage researchers in these powerful disciplines will prepare them to addressing the most critical challenges that our society will confront in the next decades making them highly attractive to both the academic and nonacademic sectors by formally embedding innovative science communication strategies earthsafe will create a new dimension of engagement with the general public and policy makers worldwide given its global scope earthsafe will support the creation of new energy and economic opportunities in vulnerable societies helping them to tackle inequality and energy poverty while at the same time consolidating europes innovation and technological capacity in doing so earthsafe will contribute to and is perfectly aligned with the main objectives of the european green deal
mechanics of nanoporous w under irradiation

fusion reactors demand materials capable of withstanding unprecedented extreme conditions refractorybased nanoporous metals offer a combination of mechanical and radiation performance that makes them ideal potential candidates for nuclear applications introducing a new material for this application requires characterizing its response under the extreme environment of fusion reactors however experimental testing facilities allowing to perform tests under these conditions are extremely limited modelling and simulation emerge as a valuable tool allowing to replace many of such tests by simulations and will become drivers in fusion materials developmentthe menawir project aims at shedding light into elusive aspects of the mechanical behaviour of nanoporous refractory metals focusing on nanoporous tungsten npw and the effect of radiation damage on its mechanical properties this will be accomplished by building a multiscale computational framework for the exploration of the mechanical properties of nanoporous metals for nuclear applications this framework will encompass stateoftheart modelling techniques from different fields including fast fourier transform crystal plasticity simulations radiation damage models and plasticity at the nanoscale to achieve this goal menawir brings together a researcher with expertise in nanoporous metals and materials modelling at the atomistic scale with a worldrecognized supervisor with expertise in modelling the nonlinear behaviour and fracture of complex microstructures at the continuum scale and a research institute with a record of excellence technology transfer and toplevel training in materials science the specific objectives are to develop a framework for the computational assessment of nanoporous materials for the nuclear industry and to provide a window of optimal npmicrostructures to guide the fabrication of npw parts menawir could lastingly impact innovation on materials for fusion
scaleup and demonstrator of luminescent waveguide encoded films for indoor photovoltaics

the internet of things iot underpins our future smart world where various electronic devices could be integrated with and controlled by wireless communication many of these devices will be standalone or portable creating an urgent demand for offgrid power sources solar photovoltaic pv cells are viable alternatives to batteries as perpetual power sources for iot devices however crystalline silicon csi pv cells which account for 95 of the global pv market are not designed to work with diffuse artificial indoor lightemitting diode led lighting and perform poorly under these conditions within the remit of the erc cog project spectracon we have developed a new photonic platform technology luminescent waveguide encoded films lwefs which overcomes these limitations by i increasing the field of view for light capture and ii converting led photons into energies that can be used more effectively by pv cells in this poc project we will advance this technology towards commercialisation through the fabrication of the prototype lwef integrated on the top surface of a csi pv coupled with testing under standardised indoor lighting conditions
nextgeneration models and genetic therapies for rare neuromuscular diseases

muscular dystrophies are severe genetic disorders characterised by muscle wasting impaired mobility and premature death which to date remain incurable although preclinical and clinical evidence position genetic therapies amongst the key emerging treatments for several genetic conditions no gene therapy or genome editing strategy has been approved for any muscular dystrophies yet the lack of robust humanised models enabling precise development of such advanced therapies is a major barrier towards their clinical translation for muscle diseases to overcome this limitation we have assembled the multidisciplinary magic consortium to build novel highfidelity models of human skeletal muscle pathophysiology which will be used to develop new vectors for safe and efficacious neuromuscular gene therapy and genome editing specific rare paediatric diseases targeted by our consortium are duchenne muscular dystrophy dmd xlinked xlcnm autosomal dominant adcnm and autosomal recessive arcnm centronuclear myopathies cnms lmna and col6related congenital muscular dystrophies cmds microfabrication microfluidics and human stem cell differentiation technologies will be used to generate diseasespecific human myofiber and muscleonchip devices qualified for commercialisation capable of screening toxicity and cellspecificity of new adenoassociated viral vector aav capsid variants and unique musclespecific lentiviruses selected vectors will be equipped with novel lineagespecific regulatory elements to further restrict transgene expression to myofibres muscle stem cells or interstitial fibroblasts reducing also potential immunogenicity the same vectors will be loaded with therapeutic genes or with new mutationindependent for dmd and xlcnm or mutationspecific for lmna and col6cmd gene editing tools which will then be validated in dystrophic rodents finally gmpcompatible batches of the top performing vectors will undergo advanced preclinical testing in large animals preparing them for future clinical translation