Dragon09/odtu_chatbot huggingface dataset:
precision studies with optically pumped beams of exotic nuclei

neutrons are fascinating particles and are important for nuclear structure tests of the standard model of particle physics or properties of neutron stars unfortunately they are electrically neutral so learning about their distribution in nuclei especially far from stability is difficult however they possess a magnetic moment which contributes to and sometimes dominates the distribution of nuclear magnetization this project aims to address the challenging question of the distribution of magnetisation and neutrons in unstable nuclei i will use a novel highaccuracy experimental approach combining radiationdetected nuclear magnetic resonance with rflaser double spectroscopy on opticallypumped shortlived nuclei the project builds on recent achievements in my team allowing to determine magnetic moments of unstable nuclei up to ppm accuracy i will combine this approach with accurate measurements of the hyperfine structure using the laserrf doubleresonance the signals will be detected efficiently using decay anisotropy thanks to spin polarisation via optical pumping this will lead to an accurate determination of a hyperfine anomaly a small effect on atomic hyperfine structure due to the distribution of nuclear magnetisation a close collaboration with atomic and nuclear theorists will allow to determine the magnetisation and neutron distribution in many nuclei light neutronhalo 11be proposed halos in neutronrich ne na mg k and ca nuclei and heavy rn fr and ra isotopes interesting for studies of atomic parity violation apv and electric dipole moments the project will take place at the isolde facility at cern i will also work closely with quantumchemistry atomic and nuclearphysics theorists who will use our data to improve their approaches this will open new perspectives for nuclear structure studies determination of neutronstar properties or apv studies it will also allow test of atomic and nuclear calculations
assembly lines in circulation smart digital tools for the sustainable humancentric and resilient use of production resources

a large part of production assets such as robotic arms conveyor belts do not reach their maximal lifetime and become prematurely obsolescent anecdotal evidence from the automotive industry suggests that 60 to 70 of production resources is prematurely taken out of operation scrapped or at best sold for spare partsthe aim of alicia is to create and demonstrate a circular manufacturing ecosystem cme for production resources such as robotic arms or conveyor belts the underlaying vision is that within five to ten years production resources will be traded and reused to their maximum utility inbetween factories in europe ultimately contributing to closing the loop of production assets as circular economy subjectsthe project aim will be achieved by integrating and demonstrating in two real industrial environments at continental and comau a combination of innovative and symbiotic digital tools as key enabling technologies behind the alicia cme ultimately enabling to design deploy run decommission and recirculate secondhand production lines 40 faster reduce material consumption by up to 80 and reuse up to 100 of the assets the innovations behind alicia include a machinereadable ontology for mapping factory owner requirements an aimatchmaking engine for combining incumbent factory assets with secondhand assets coming from the alicia online marketplace a plug produce middleware for seamlessly connecting the production assets and a digital shadowdigital twin to rampup and operate the alicia secondhand line novel circularityasaservice business models will be evaluatedalicia addresses the eu machinery and equipment as well as machinery repair service market segments which together contributed 288 billion eur in value added to the eu economy in 2018 alicia is expected to contribute to increasing the eus resilience against disruptions in global supply chains and significantly contribute to the creation of a circular economy
the musical avantgarde in rome in the 1960s actors and networks in music history

romavantgarde aims to reveal a particular phenomenon in the history of music the effervescence of avantgarde networks in rome during the 1960s this phenomenon saw the first steps of influential figures to come frederic rzewski alvin curran and ennio morricone but it is also of particular interest as it involved a large number of artists from varied national and cultural horizons connected diverse institutions schools bars religious establishments and saw the encounter of various genres art music jazz and popular music to create original repertoires as a consequence this is an ideal case to show how art music creationdespite the enduring paradigm of the individual geniusis a collective phenomenon involving human but also nonhuman actors institutions artifacts ideas to do so romavantgarde will draw specifically on actornetwork theory ant but also on social network analysis sna through this case study romavantgarde aims to advance knowledge on the history of twentiethcentury music and to reveal rome as a cosmopolitan city actively participating in the construction of the european musical landscape at the same time it aims to further research on creativity and to encourage the recent exchanges between network theories and music studies this project will be undertaken in sapienza university of rome a reputed university for research in the history of music sapienza is also the ideal institution to carry out research in the citys libraries and archives and to carry out the collection of testimonies before witnesses disappear professor emanuele senici an internationally renowned music historian with extensive experience in the history of modern and roman music will supervise this project this experience is thus expected to have a profound impact on my training scientific maturity and reputation and to place me in good stead to qualify for a tenuretrack position in europe
scaling democratic innovations

scaledem aims at unlocking the uptake of democratic innovations born in ri actions in particular stemming from eufunded projects this is achieved by developing a scaling infrastructure including policy roadmaps and an actionable compass for scaling democratic innovations based on a grounded theory of scaling scaledem helps researchers practitioners and policymakers assess opportunities and barriers for scaling democratic innovations along four dimensions scaling high impacting laws and policy out impacting greater more and new people deep impacting cultures and identities and in impacting processes quality scaledem starts by analysing innovative solutions developed in ri projects on the issue of citizen participation and engagement in democratic governance in particular horizon projects whose end date is after january 2023 to develop a theory of scaling following a collaborative and interdisciplinary translation process in its translation hub scaledem deploys two ambitious scaling grounds in the forms of twinning and pilot programmes the scaling grounds test and encourage the uptake of democratic innovations by new end users scaling the societal impact of those solutions further scaledem establishes iterative feedback and capacitybuilding mechanisms to support the replicability and adaptability of solutions in new operational environments and actionability of theoretical solutions in parallel scaledem involves and nurtures a global community of end users it leverages strategic partnerships with relevant ri projects initiatives and networks notably the network for innovative solutions for the future of democracy to overcome the fragmentation of knowledge identify opportunities to increase synergies for capacitybuilding actions to policymakers practitioners and researchers and expand the societal and political impact of eufunded research in the eu and countries from global europe
targeting b cell activation driven by natural killer cells

autoimmune diseases affect nearly 4 of the worlds population and can be lifethreatening among them primary sjögren syndrome pss is the most common systemic autoimmune disease unfortunately to date treatments are focusing on relieving symptoms it is of public relevance to find potential new biomarkers for treatments b cells are one key player in pss and promising drugs targeting b cell activation are currently under phase 3 clinical trials restraining b cell hyperactivity is central to treating pss permanently hence instead of targeting b cell activation pss treatments would also benefit from targeting signals or interactions leading to b cell activation the tabank project aims to address this hypothesis by using cuttingedge technologies highparameter flow cytometry singlecell sequencing technologies and unsupervised analysis to interrogate the immune network in the circulation of pss donors as well as in the inflamed environment of impaired salivary glands this overarching goal will be achieved by i compiling a comprehensive database of immune cell profiles in pss using both singlecell sequencing and highparameter mass and flow cytometry ii determining potential interactions of immune cells leading to b cell activation using a novel computational approach and iii validating these interactions using ex vivo culture tabank will be conducted at the lymphocytes b autoimmunity and immunotherapies center universit of brest occidentale a leading research institution in the study of immunotherapies for b cell diseases this project will be supervised by two leading experts in autoimmune diseases and b cell biology this unique synergy in addition the researchers own expertise in examining immune responses in human tissues particularly oral mucosal tissues will precondition the project for success while facilitating a mutually beneficial twoway transfer of knowledge
highly efficient and sustainable refrigeration based on solid state magnetic cooling device

cooling and refrigeration account for 78 of global greenhouse gas emissions and 20 of electricity demand the standard refrigerant fgases have a tremendous global warming potential gwp and are being phased out in the eu available alternative gases are either toxic or explosive posing serious issues for their applicabilitymagnotherm has developed the first industrially feasible refrigeration unit based on magnetic cooling technology that uses a specific class of material and alternating magnetic fields this is achieved thanks to a patented process to mass produce highly performant stable and cheap magnetocaloric materials using abundant noncritical materials and to interdisciplinary backgrounds and worldleading research resulting from tu darmstadtmagnetic cooling implements a solid state cooling cycle using no refrigeration gas with 0 associated gwp no risk to the environment and no issues of flammability it is x3 more efficient and achieves 40 electricity savings
quantumenhanced freeelectron spectromicroscopy

ultrafast electron microscopy relies on the spatial spectral and temporal manipulation of free electrons with nmmevfs precision to map the structural dynamics as well as the vibrational and electronic ground and excited states of nanomaterials with quefes i will introduce a conceptually disruptive approach to capitalize on the quantum nature of free electrons and their interactions with matter and radiation fields aiming to obtain previously inaccessible information on the atomicscale dynamics of such materials to reveal hidden properties of the quantum vacuum and to control the manybody state of quantum matteri will address five challenges of major scientific relevance i the spatiotemporal control over the density matrix of free electrons by interaction with suitably designed optical fields to overcome the current limits of spacetimeenergy resolution in timeresolved electron spectromicroscopy ii a disruptive approach to map the nanoscale quantum fluctuations and the outofequilibrium state associated with optical near fields in vacuum and polaritonic excitations in nanomaterials iii a fouriertransforminspired method to image the spatiotemporal evolution of atomic structures charge carriers and dynamical screening iv the use of free electrons to flexibly read and write the manybody quantum state of trapped rydberg atoms and quantum gases and v the realization of allelectron pumpprobe spectroscopy combined with the formation of dynamically screened multiple freeelectron bound states for lossless charge transport in a semiconductori will pursue these research frontiers by relying on the strong interdisciplinary theoretical background of my group at the intersection between electronlightmatter interactions and nanophotonics introducing a change of paradigm in the use of free electrons to break the current limits of spectromicroscopy and having the potential for revolutionizing our ability to image and manipulate the nanoworld
asymmetric carbyne catalytic transfer to streamline synthesis of chiral amino carbonyls

the chiral amino carbonyl is an important structural motif prevalent in natural products and therapeutic agents despite that many methodologies have been developed for their diastero and enantioselective synthesis most of these methods require multistep manipulations with prefunctionalized substrates that fail to introduce the amino carbonyl moiety at the latestage of complex molecule synthesis chiralbeta aims to develop an innovative technology to rapidly construct chiral amino carbonyl derivatives with feedstock and fine alkenes as well as with complex drug moleculesnatural products based on a rhcatalyzed asymmetric carbyne transfer platform a key strength of this conceptually new and multidisciplinary proposal is the introduction of a secondment phase in novartis basel to explore reallife applications the ambitious action merges perfectly the expertise of the host in novel ch and cc bond functionalization strategies based on the catalytic generation of carbyne equivalents with the strong background of the applicant in metalcatalyzed asymmetric reactions thus enhancing twoway transfer of knowledge between the er and the host group this project will expose the fellow to a wide range of cuttingedge chemistry and biomedical sciences in an interdisciplinary and international environment iciq novartis and enable the fellow to become a leader for the next generation in the field of chemical synthesis and latestage functionalization techniques
technology for highrepetitionrate intense laser laboratories

the thrill project deals with providing new schemes and devices for pushing forward the limits of research infrastructures ri of european relevance and esfri landmarks to do so the project partners have identified several technical bottlenecks in highenergy highrepetitionrate laser technology that prevent it from reaching the technical readiness level required to technically specify and build the needed devices and guaranteeing sustainable and reliable operation of such laser beamlines at the partnering ris advancing the technical readiness of these topics is strategically aligned with the longterm plans and evolution of the esfri landmarks fair eli bl and euxfel and ri apollon bringing them to the next level of development and strengthening their leading position the project is well focused and it is deliberately restricted to three enabling technologies which require the most urgent efforts and timely attention by the community highenergy highrepetitionrate amplification highenergy beam transport and optical coating resilience for large optics to reach our goals the major activity within thrill will be organized around producing several prototypes demonstrating a high level of technical readiness our proposal is addressing not yet explored technical bottlenecks such as transport over long distances of largeaperture laser beams via relay imaging using allreflective optics and aims at proposing concrete steps to increase the performances and effectiveness of the industrial community through the codevelopment of advanced technologies up to prototyping in operational environmentsthe project is not only pushing technology it is also offering an outstanding opportunity to train a qualified work force for ris and industry with this in mind the structure of thrill promotes synergetic work fast transfer to industry and integrated research activities at the european level access to the ris will be granted as inkind contribution
climate effects reduced by innovative concept of operations needs and impacts assessment

ciconias ambition is to improve the understanding of nonco2 emissions with regards to the current aircraftengine technologies and operating fleet as well as their evolution and their climate effects but with the clear objective to evaluate and develop impact reduction solutions covering several promising mitigation options on flight operations through the definition of innovative dedicated concepts of operations conops and their assessment in comparison to legacy operations ciconia wants to define and assess conops solutions with engagement from all concerned stakeholders airlines with their occ network met providers and air traffic control ciconia mitigation options will offer the best proposal for reduction in climate impacts taking into account both the co2 and nonco2 climate effects a trl4 is targeted at the end of the 3 years projectciconia is composed of the four main topics1 a weather service that will improve weather forecasting capabilities tailored for operational mitigation concepts provide technical enablers definition and recommendation for long term improvement that will feed a better understanding of the stakes2 a climate enabler that will improve climate impact assessment and models tailored for operational mitigation concepts3 conops strategies definition ciconia proposes to further analyse how operational stakeholders could integrate mitigations in their plan or in their tactical operations to mitigate climate impacts a climate enhanced operations conops will be delivered and assessed with representative fast time simulation platforms integrating weather and climate models enabling the evaluation of a large area and long time period these simulations will support the assessment of the complete picture from climate economics and operational impact points of view conducting trades on different assumptions understanding their impact on the decision making and finally providing guidance4 an atm mitigation solution through trials investigate multiple atm strategies for flights to minimise or avoid persistent warming contrails through operational trials and data analysis this solution will focus on reducing the climate impact of nonco2 components specifically by minimising crossings of persistent highly warming contrails from aircraft in oceanic airspaceciconia aims as well at providing material to authorities and regulators to analyse the appropriate rulemaking that could serve a fair and uniformed framework to minimise nonco2 climate effects in a global environmental centric approach addressing as well co2 regulations aimed at mitigating nonco2 effects through operational measures should be proven effective from a climate benefit standpoint fair from an economic impact on the operators standpoint and operationally feasibleacceptablemanageable an advisory board will federate external organisations who want to take part in the ciconia results
motivation and engagement in disaster mapping in europe

we should not be seeing this number of people dying in 2021 from floods it just should not be happening hydrologist h clokes words echoed the widespread shock following the death of 243 people in some of the wealthiest and most technologically advanced countries in the world during the european 2021 floods extreme weather events such as floods and heat waves are expected to increase in frequency and intensity in the future ipcc as communities grow more exposed to hazard risks in addition to state preparedness and urban resilience it is urgent to address public involvement in disaster preparedness dp measures to promote individual preventive behaviour sfdrr 20152030 despite eu advances in disaster maps dm tools and disaster management procedures of community professionalisation dm are used mostly by expert stakeholders but are seldom userfriendly for citizens and current dp initiatives suffer from limited public motivation and engagement people do not exist in a vacuum and social and cultural dynamics play a crucial role in defining risk and motivation to engage in dp thus dp strategies should include a systematic assessment of the impact of sociocultural and spatial factors on peoples motivation and engagement in dp to inform better disaster training the motivation and engagement in disaster mapping in europe medime project proposes a theoretical framework of motivation and engagement and a new disaster training based on interactive hm to investigate motivation and engagement in dp and the use of dm for foreign residents an original sociocultural and spatial model to understand peoples motivation to participate in dp initiatives based on the japanese dp research and measures will be implemented for japan has always been at the forefront of dp for high levels of community engagement and mainstreamed dm project results will increase the impact of eu dp strategies and inform useful dm uses for the broader public
function of cholangiocytes in chronic liver diseases

cholangiocytes are the mcholangiocytes are the main cell type lining the epithelium of the biliary tree a network of conduits which drain the liver from bile produced by hepatocytes while the role of cholangiocytes have been broadly studied in the context of cholangiopathies their role in chronic liver disease affecting hepatocytes is often overlooked despite growing evidence that they play a central role in disease progression regeneration and cancer thus understanding the mechanisms controlling the regenerative potential of cholangiocytes is essential to develop new therapies promoting tissue repair or blocking tumour formation however the study of these mechanisms has been restricted by technical and conceptual barriers especially in humanhere we propose to bypass these limitations by developing an innovative program of research combining functional experiments in organoids single cell analyses on human primary tissue and preclinical studies in animal models we will use this approach to specifically address the role of cholangiocytes in chronic liver disease more precisely we aim to uncover the mechanisms driving cholangiocytes activation plasticity and transformation importantly we hypothesise that these different processes are interlinked and share common factors the funchol program will systematically address these questions in the context of nonalcoholic fatty liver disease nafld this chronic disease and its progressive form nonalcoholic steatohepatitis nash represent the most rapidly rising cause of liver cirrhosis worldwide and there is currently no therapy for this major health care challenge overall this multidisciplinary proposal will reveal the molecular interplays by which liver injuries can affect cholangiocytes and how in turn cholangiocytes react to improve tissue repair or to aggravate disease this research will pave the way for the development of new therapeutics controlling regeneration to limit disease progression