Dragon09/odtu_chatbot huggingface dataset:
interplay of epithelial mechanics and neutrophil activation as a pathomechanism in refractory ibd and colorectal cancer patients

inflammatory bowel diseases ibd are a heterogeneous group of disorders characterized by gastrointestinal tract inflammation being crohns disease and ulcerative colitis the most clinically abundant ibd affects around 68 million people all over the world being europe the continent with the highest prevalence although antitnf monoclonal antibodies are a breakthrough therapy almost 40 of ibd patients do not respond to therapy or acquire resistance this leads to uncontrolled inflammation that prolonged in time constitutes a higher colorectal cancer risk this justifies the current efforts to identify innovative therapy targets for ibd understanding of the molecular processes behind personalized medicine the fact that an increased intestinal permeability precedes the onset of inflammation possesses epithelial disruption as a potential etiological factor in ibd moreover in recent years several publications have highlighted that an impaired epithelial barrier is linked to resistance to therapy nevertheless how altered epithelial mechanics can influence the structural properties of the extracellular matrix and immune cells migrating through it is not fully understood on the other hand the role of neutrophils as resistancetotherapy players has emerged very recently then we hypothesize that an alteration in epithelial cell mechanics constitutes a primary event that impacts the proliferation and behavior of the first immune cell responders neutrophils this would further contribute to ecm remodeling and fibroblasts polarization to iafs another mechanism implicated in therapy resistance then interconnections aims to elucidate how an altered epithelial dynamics constitutes a primary event that directly through an altered transepithelial migration or indirectly affecting the mechanical framework could promote the accumulation of activated neutrophils
overcoming limits for preclinical small volume liquid delivery into skin and inflammation quantification

chronic inflammatory skin diseases have a huge burden on patients their families and the economy new patientfriendly delivery methods are urgently needed targeting immune cells in the dermis injecting small volumes of biologics directly in skin lesions using needlefree technology would revolutionize treatments and shift the systemic dosing paradigm to individualized local dosinghowever to realize this vision there is a long path to test its effectiveness in preclinical in vitro ex vivo and clinical studies first testing new drugs is costly and often involves tests with animals with poor translational value because of differences in skin anatomy with humanstherefore with this project we will establish the proof of concept that bubble gun a minimal invasive injection method can effectively be used for innovative drug testing via skinonchip technologywe will study in vitro skin inflammation response with plasma activated water and active pharmaceutic ingredients used in treating skin diseases such as eczema atopic dermatitis and psoriasis lastly in collaboration with several stakeholders we will prepare a business plan to clear the way for further developments and establish the best path to revolutionize drug delivery into skin and cosmetics
designing and recycling sustainable electronic boards for a european circular economy

desire4eu aims at proving the concept of a radically new sustainable approach to produce use and recycle electronic printed circuit boards pcb that combine technical performance economic and ecological efficiency throughout their life cyclethe projects vision is of sustainable circular pcb manufactured in europe using biobased and biodegradable materials it disrupts current paradigms and significantly reduces harmful waste enabling fast and ecological copper recovery above 70wt of pcb ultimate waste elimination and 12 electronics sector co2 emissions decrease by combining material science green chemistry electronics environmental microbiology life cycle and value chain assessmentsour holistic approach considers boards as a complete system and develops a proof of concept and guidelines for exemplary fully circular sustainable electronics solutions contributing to european leadership resilience and independence we envision a worldfirst by 2030 industrially credible compliant biobased rigid boards with an innovative and environmentally friendly recycling process for critical metalsdesire4eu has 4 smart specific objectives 1 the complete assembly of a technology compliant biobased multilayer pcb 2 an environmentally friendly and timeefficient bioleaching process 3 a circular by design approach materialized by guidelines for further uptake 4 an advanced costeffective but large proof of concept attracting 2000 5000 students responsible citizens and industries from learners to prosumersthe consortium gathers 8 academic and private partners from 5 european countries including 2 smes and 1 startup desire4eu is managed by ginp represented by full professor p xavier who has extensive scientific and management experience the partners expect at least 7 open access articles and 3 patents for this disruptive technology to be exploited in the field of class 2 rigid boards with a potential market of 436 million
spacesense democratizing satellite imagery for machine learning

spacesense is a french deeptech spaceai company created in 2019 our mission is to democratise access to intelligence from earth observation eo technology by making it possible for data scientists to create applications using eo data without the need for expertise in remotesensing nor any infrastructure investment with us our users build an eo product in days instead of months and at 20 of the costwe are building a platform to simplify endtoend data preparation for satellite imagery ai solutions we have released a first version of the platform earlier this year that allows a user to access different types of satellite imagery sentinel1 sentinel2 in an analysis ready data format combine it with weather data add various proprietary datasets like drone sensor data or other geolocated data generate a clean featurecube compatible with tensorflowpytorch models to create practical solutions and at scale thanks to spacesenses compute engine a proprietary system finetuned to perform large scale ondemand eo data analysis on cloud we have ongoing pilots trials with the first release of the platformthrough women tech eu we aim to develop a core technical component of data preparation for ai capabilities to help us create a clear competitive advantage to achieve productmarket fit in 2024 and set up the processes for a more diverse and gender balanced workplace as we grow our teamthis will be achieved through four main tasks detailed in the proposal data augmentation tool for sentinel2 imagery creation of solution template marketing and sales hr tools processesjyotsna budideti is the cofounder and ceo of the company she has been driving the companys vision and strategy on a daytoday basis she leads the product development management of technical team gtm strategy of the company her team currently has 6 different nationalities and is composed of about 12 women with a goal to reach 40 by 2024
scalable ferroelectric based accelerators for energy efficient edge ai

the ferro4edgeai project will provide an ultralow power scalable edge accelerator for artificial intelligence incorporating a memory augmented neural network based on low cost high density multilevel back end of line beol integrated ferroelectric fe technologywe expect to achieve a 2500x gain in energyefficiency to break the popsw barrier with respect to the stateoftheart cmos accelerators and predictions for other emerging technology ai hardware to do so five ambitious specific objectives have been selected multilevel functionality in hafniabased thin films by investigating the optimum tradeoff in memory window film thickness stability of the ferroelectric state low operating voltage for the nonvolatile memory and robust multilevel operation of the fefet2 for high density logic operations and data storage a low operating voltage is mandatory for power rating reduction while robust multilevel operation is essential for analogue inmemory computing at the edge integration and characterization of multilevel low voltage fefet2 arrays definition design and demonstration of a low power fe ai accelerator suitable for scalable systems integration systems simulation of ultralow power fe accelerator enhanced edge processing for targeted edge applications of voice and image recognitionferro4edgeai is a multidisciplinary project engaging 12 partners from 6 countries covering the academic and industrial worlds including 2 smes an implementation plan is presented in the form of 6 work packages 5 of which are technical in nature synergy in communication and dissemination by the several partners and stakeholders including an external advisory board and collaboration with south korea will maximize the project progress and impact solutions to overcome the fundamental technological barriers as well as appropriate deliverables tasks milestones and risks to complete the project objectives in due time are presented
metal complexes of a naturally inspired framework functionalized for cytotoxic and catalytic efficiency

the immense power of practiceoriented synthetic chemistry is demonstrated through the opportunity to design synthesize optimize produce and apply a molecule of a desirable structure for a given purpose in the light of its ability to bridge chemical structure with a function meteffect proposes brand new concept of novel multifunctional rhenium and iridium flavonoid complexes aimed to serve as metallodrugs and homogenous catalysts the fusion of academic knowledge and industryoriented perspective establishes a fruitful collaboration of an international and intersectoral profile wellrecognized members of consortium gains beyond thestateoftheart advances in bioinorganic chemistry by a developing novel re and ir complexes containing apigeninlike ligands a natural bioactive flavonetype of molecules b determining the antitumor potential of newly synthesized rev and iriii complexes on a panel of various human cancer cell lines c evaluating the applicative potential of novel rev complexes as homogeneous catalysts in oatinspired reactions olefin epoxidation oxoanions catalytic reduction and water oxidation the structure and sentence of 7 work packages implemented through 37 secondments will enable the promotion of newly synthesized metalbased compounds in industrial environment for the sake of reaching their final applications the widespread partnership creates an outstanding ri oriented ambient ensuring free knowledge sharing and career upgrade of the participating staff by developing functional metalbased molecules meteffect encompasses full human intellectual capacity capable to challenge technical economic and environmental demands of wider society for applied but sustainable chemistry
bayesian gaussian processes or how i learned to stop worrying and love nonlinear social science

nonlinearity is ubiquitous in the social sciences in crosssectional research nonlinearity naturally follows from the fact that variables often depend on human perception the tendency to share fake news for example depends in a complex nonlinear manner on peoples personality and political preferences in longitudinal research nonlinearity follows from the fact that temporal social processes are nonstationary by nature for instance stressful life events eg unemployment pandemic have a complex nonlinear impact on wellbeing over time to study these nonlinear phenomena much more data are needed than in linear analyses therefore researchers increasingly rely on technological innovations to collect rich data such as panel data via online surveys experience sampling data via mobile apps or temporal social network data using digital communication eg email in addition prior information eg from experts is often available to inform us about plausible nonlinear shapes a crucial problem is however that statistical approaches for learning nonlinearity still heavily rely on oldfashioned techniques which can only model simple curvilinear effects and are unable to include external prior information our understanding about nonlinear phenomena therefore remains limited this project aims to resolve these shortcomings by developing cuttingedge methods for nonlinear social science using bayesian gaussian processes with this nonparametric methodology we can learn complex nonlinear shapes add prior knowledge and test nonlinear theories implementation in userfriendly software will ensure general utilization tailormade extensions will be developed for crosssectional data panel data experience sampling data and temporal social network data after this project we will be able to truly understand complex nonlinear mechanisms to learn how these unfold over time and to make accurate predictions eg of wellbeing after life events
commercial fusion energy with shortpulse highintensity lasers and nanostructured fuel targets

to achieve climate targets while maintaining industrial value creation and prosperity in europe eu companies must be able to switch to clean and competitive energy marvel fusion mf founded in munich in 2019 pursues a new and fasttrack to commercialize fusion energy the unique approach builds on the laserfusion concept of the national ignition facility nif where energy gain was demonstrated for the first time in 2022 with diodepumped laser systems nanostructured targets and the use of mixed fuels mf bypasses the main problems of traditional fusion concepts to achieve a commercially viable power plant concept mf has performed more than 2000 experiments over the past three years to validate its approach with the completion of the demonstration facility in colorado by 2027 with two proprietary laser systems developed in collaboration with sprind mf will reach a full proofoftechnology with infrastructure and laser of the facility already fully funded afterwards mf will build a pilot powerplant by 2033 with 100 mw output with siemens energy as development partner to achieve their ambitious goals mf has assembled a worldclass team of scientists and entrepreneurs and a network of academic and industrial partners including collaborations with colorado state csu stanford and lmu furthermore european companies like thales and siemens energy assist mf in the development and industrialization of mfs technology
histories of reception of photography in the ottoman empire

histories of reception of photography in the ottoman empire hrpoe action is the first indepth study to analyse how the ottomans grasped the photographic medium that emanated from a different epistemological and cultural context and what kinds of uses and meanings they attributed to it it is a media historiographical investigation that differentiates between three imperial groups in their stance towards photography military officers of imperial higher education institutions armenian entrepreneurs and enthusiasts among the upperclass muslims to examine how each group conceptualised the medium it turns to their publications on photography and engages with them through contextual and comparative analysis the research aims to reveal how each groups interpretation of photography depended upon their epistemic and cultural interactions with the ottoman modernization and the west in this way it pursues to disclose the heterogeneity of experiences and knowledge structures involved in the reception of photography in the ottoman empire
cell size as driver of stem cell aging and cancer

the failure to regenerate tissue underlies a challenging health issue in elderly a main contributor to this decline is the loss of stem cell function during aging despite the essential role of stem cells it is unclear how they fail to maintain their functions during aging and disease i discovered a new aspect of stem cell aging in vivo cellular enlargement with age stem cells increase in size leading to their functional decline however it is unclear how size impacts stem cell fitness moreover the physiological importance of this process remains unsolvedmy team at the university of helsinki will address these questions by 1 identifying pathways that promote stem cell dysfunction during enlargement 2 assessing the effects of size reduction on stem cell rejuvenation and 3 illuminating the effects of stem cell size on cancersupported by preliminary data i hypothesize that cell size is a driver of stem cell aging and cancer using hematopoietic stem cells hscs of mouse models i will identify the molecular mechanisms impairing fitness of large hscs i will also perform a screen to identify pathways that modulate the size of hscs to test for rejuvenation these will allow me to establish how hsc size affects other cellular aging pathways organismal health and whether this relationship is causal or correlative i hypothesize that cellular size impacts hscs to transform into cancerous cells to test this i will use differently sized oncogenic hscs from mice and humans to test their potential to facilitate leukemia in vivo and to investigate the underlying mechanisms of this processthe novel concepts outlined here have exceptional potential for scientific impact as they add a new paradigm to stem cell aging provide transformative treatment perspectives and examine cancer from a new dimension
personal and nonpersonal forms of address in three contiguous romance languages sociolinguistic approach and gender implications

the proposed research project focuses on secondperson address forms eg tuvous in french and nonpersonal strategies that avoid any reference to the addressee eg impersonal constructions in three contiguous standard languages european portuguese peninsular spanish and french from france and from belgium address forms provide information about a number of features related to the interlocutors age sociocultural level gender etc the type of relationship they share eg close friends vs distant acquaintances and their relative social roles eg boss vs employee therefore analysing these forms may reveal social differences in terms of hierarchy or distance that show inequalities in spite of the existence of relatively similar forms due to their common latin origin the use of the address forms differs across the three languages indeed the literature has not yet provided a full picture of the use of these forms because of their variability in speech and the many factors that influence which form is chosen depersonalisation aims to fill this void with an empirical approach based on a triangulation of methods and a combination of natural and elicited data from five different sources the project seeks to establish for each language a sociolinguistic correlation quantitative analysis between the use of each form of address including nonpersonal strategies and the contextual and sociolinguistic variables of speakers and addressees focusing on their gender since little attention has been paid to this variable in research on these languages furthermore concerning the nonpersonal strategies an innovative pragmalinguistics study is carried out of which types are used qualitative analysis in relation with these variables finally the project includes a multicontrastive analysis between the three languages to show common and different patterns of use focusing on the importance of the participants gender variable
creating future societal resilience through innovative sciencebased cocreation labs

the futuresilience project aims to strengthen european economic and social resilience through an enhanced ability to quickly respond to future crises this will be accomplished by facilitating the fast and effective use of policy relevant research and innovation ri findings for actors at national regional and local level the project has four specific objectives1 map existing policy relevant european ri findings with high potential to inform policy making for economic and social resilience and to help address societal challenges at local level2 define a set of methodologies for testing in how far the identified ri findings can inform policies addressing national regional and local needs3 implement the testing methodologies through multistakeholder experiments across europe in cocreation with stakeholders from research policy economy civil society organisations as well as citizens4 develop a knowledge base of the successfully tested research findings with high capacity to inform policy actors and a toolbox of methods for testing policy relevant research findingsfuturesilience will set up future resilience labs to test policy relevant ri findings through 10 pilot exercises three preidentified working on climate change migration and the financial crisis and urban planning and seven selected through an open call during the experimentation multiple stakeholders will discuss and test evidencebased strategies tailored to their specific context and matching their local needs aiming at reducing vulnerabilities and increasing capacities to be prepared for multiple types of possible crisis the project will be implemented by a robust consortium with knowhow in the fields of resilience ri policy and crisis management as well as experience with various cocreation and participative methodologies and specifically handson experience with foresight scenario planning virtual simulation and agentbased modelling
equivalent representation of modern power systems with power electronics for stability analysis

modern power systems have been increasingly penetrated with power electronic converters this can be explained with the massive integration of renewable energy generation energy storage utilities transport electrification industrial electric drives as well as the wide application of high voltage direct current hvdc and flexible alternate current transmission systems facts power electronic converters have totally different characteristics compared to conventional synchronous generators as they are fully controllable devices with low inertial and very limited overload capability these characteristics also increase the complexity to stability analysis of power systems dominated by converters an accurate grid equivalent representation stands for a powerful tool to improve the efficiency for stability analysis of such system in such context the equator project aims to develop an effective grid equivalent representation for stability analysis of power systems dominated by power electronics under both smallsignal and largesignal disturbances the obtained equivalent representations will provide powerful tools for tsos oems and research institutes involved in the planning design operation and analysis of modern power systems furthermore the project results will favour the evolution towards the future european super grid which involves a high penetration ratio of renewable energy generation and covers a large geographical span the researchers previous work focused on computational analysis and steadystate grid equivalent representation for powerelectronicsdominated systems which demonstrates his appropriate profile to successfully implement the presented project under the guidance of the supervisor who is an expert in stability analysis of power electronics systems