Dragon09/odtu_chatbot huggingface dataset:
crystals of single chirality via nonequilibrium routes

the molecular building blocks of life are of only one handedness consequently pharmaceuticals and other bioactive molecules also need to be of one handedness when such enantiomers crystallize in separate crystals isolation of the desired handedness is relatively straightforward unfortunately most enantiomers 9095 are thermodynamically more stable as racemic compounds with both enantiomers in the crystallographic unit cell which impedes any such separations there are currently no methods to systematically overcome this major bottleneck thus hindering simple routes towards many essential enantiopure molecules this proposal is aimed at overcoming this fundamental challenge by establishing new principles to turn racemic compounds into molecules of a desired handedness by liberating them from their thermodynamic constraints to achieve this ambitious goal we introduce a revolutionary new approach manipulating the stability of crystals by subjecting mixtures of crystals to nonequilibrium conditions building upon our preliminary work we hypothesize that growthdissolution rates can be manipulated by selecting crystallization conditions such that the thermodynamically stable racemic compound is converted into the desired enantiomer to achieve this ambitious goal the main objectives of this proposal are to i demonstrate the proofofprinciple ii identify the essential parameters and iii understand the mechanism behind this methodology the results of this erc consolidator will hold direct relevance for our fundamental understanding of nonequilibrium conditions in reactive crystallizations and the outcomes of this research will immediately impact our ability to produce molecules of single handedness ultimately this breakthrough holds the potential to disrupt the pharmaceutical industry by offering versatile sustainable and simple routes towards essential enantiomerically pure building blocks that are crucial in our daily lives
strengthening the resilience of textile aerospace and construction smes to transition towards greener and more digital sectors with social and business innovation

in transit aims to strengthen the resilience of textile aerospace and construction smes towards greener and more digital sectors withsocial and business model with a mixed support mechanism including individual assessment support and a lump sum and coachingto ensure their consolidation and sustainabilityin transit will provide an open online collaborative platform involving innovation actors from the aerospace construction and textilesectors that will serve as a space for sharing best practices and as a matchmaking system for new ideas for innovation and circulareconomy and new collaboration partnershipsfoster crossregional and crosssectoral links with dedicated learning visits in combination with innovation workshops andmatchmakings to establish the seed for collaboration among sectors by identifying potential partners for commercial and innovationcooperation that will ultimately generate growth opportunities for smesincrease resilience of smes by supporting their transition to more sustainable business models financing of a feasibility studyprototyping pilot testing demonstrating procurement of further specialized consultancy services and coaching services that cannotbe provided directly by the project partners an adaptation of business processes option to access to dihs testing facilities theintroduction of new it solutions and social innovation strategiesscaleup support to leverage additional funds in transit will connect successful smes with other initiatives for scaling up theinnovationsin transit will allocate 4 m directly for sme support out of 5m 80 of total budgetin transit partnership will allow to reach directly as cluster members 700 smes 140 large companies and over 150 research facilitiesacross 7 eucountries and indirectly over 5000 smes across 38 countries though euwide networks and european strategic clusterpartnerships
rewiring of ecological networks under global change

one of the main consequences of the biodiversity crisis is the reorganization of ecological networks this reorganization usually termed interaction rewiring can drastically alter natures functions and services to humanity therefore predicting interaction rewiring is paramount to predicting the future structure functioning and stability of the ecosystems until now this has not been done because quantifying and predicting rewiring into the future requires extensive data on species traits and interactions and computationally efficient and ecologically relevant analytical tools the main objectives of econet are to quantify the potential of rewiring in mutualistic networks globally and to predict how mutualistic networks rewire due to global change climate change land cover change humandriven extinctions for this i will use empirical data of pollination and seed dispersal networks to predict probabilities of all pairwise interactions in metawebs network covering all possible pairwise interactions with machine learning i will quantify the species rewiring potential as their interaction niche breadths in the metawebs then i will construct scenarios of compositional change in local networks caused by global change and identify rewired interactions under different scenarios i will also assess the stability and functionality of rewired networks under different scenarios the main outcome of econet will be spatiallyexplicit knowledge of global change consequences on mutualistic networks econet will provide practical and novel guidance to biodiversity management and conservation strategies including naturebased solutions embedded in the eus environmental agenda as a key part of econet i will receive essential training from worldleading experts in the fields of ecological machine learning and scenario development at an outstanding centre this will allow me to establish an independent and distinct research agenda in global change ecology
wood residues derived microcrystalline cellulose for sustainable materials

woodcell aims to further build on fibenols unique sweetwoods production facility to enable production of microscale specialty microcrystalline cellulose mcc from woody biomass sources that is significantly more affordable than cellulose materials with comparable properties woodcell is highly efficient 95 vs 4050 for alternative commercial processes with energy usage 3 times lower in addition woodcell mcc is produced at high solids content 1820 before drying and is colloidally stable overcoming the usual negative effects of dewatering during processing woodcell will achieve competitive price even against other abundant chemicals this combined with the unique properties will enable woodcell to unlock new markets globallywoodcell will design and build a sustainable costeffective firstofakind flagship mcc biorefinery producing 4 kty by 2029 the modular design combined with existing ip and freedom to operate will be key factors to enabling the rapid commercial exploitation and replication following the successful build and operation of the woodcell mcc plant woodcell will move into a replication phase and build a new mcc production facility capable of producing 20 kty by 2030based on these unique mccs woodcell will develop the whole value chain from the feedstock supply to processing and production steps in order to create the basis for at least 5 new biobased value chains and create at least 5 new consumer products produced from biobased materials based on existing commercially viable products from out industrial partners ds smith a multinational packaging business coatex a multinational manufacturer of specialty materials and skeleton technologies is a hitech company that develop energy storage solutions
developing climateresilient and ecosustainable railway earthwork by mitigating geohazards while balancing biodiversity

the resilient and sustainable development of railway networks is fundamental for economic and social progress especially under the current climate to achieve this we must embrace new innovative solutions while replicating best practices that benefit nature alongside increasing the infrastructure resilience and safety we need transformative changes in railway earthwork asset development that go beyond prioritising decarbonisation and digitalisation and seek to restore nature safeguard biodiversity and produce positive outcomes for human societies leveraging cuttingedge technologies like ai earth observation statistical analysis advanced numerical modelling laboratory tests and sensor technologies resolve seeks to integrate conventional engineering practices with life sciences empowered by data science furthermore resolve will pioneer synergistic solutions that tackle climate change adaptation in railway earthwork assets while creating opportunities for nature restoration this attempt involves developing naturebased solutions nbs and environmentally friendly construction materials with the additional aim of fostering biodiversity restoration beyond ground reinforcement highly skilled researchers and practitioners capable of dealing with such problems are scarce and in high demand by academia and industry thus formed with 11 world leading research organisations and 3 companies across europe and internationally with expertise and facilities in these areas resolve aims to ensure comprehensive robust and implementable solutions are obtained for railway network climate resilience built and ecosustainable development the network is carefully designed to enables research and innovative staff exchange across all aspects resolve secondees will enjoy a highly integrated interdisciplinary and intersectoral staff exchange sharing knowhow and skills development environment through the planned secondments networkwide events and local trainings
the macroeconomics of managers

there are enormous differences in productivity both across countries and across firms within the same country not only is the average firm less productive in poor countries the allocation of resources across firms is also less efficient good management is understood as one of the key determinants of firm performance why dont management best practices spread from good firms to bad ones and from rich countries to poor ones in order to explain management practices and productivity at the macroeconomic level we need to understand where good managers come from and how they are allocated across firms i propose a new research agenda of the macroeconomics of managers i will build three quantifiable theories to describe the market for manager skills and estimate them in new longitudinal data on the universe of firms and top managers in germany 19912021 and hungary 19802021 i will study the increased demand for manager skills after economic liberalization of the 1990s the geographic and other frictions stopping managers from reaching their full potential at their ideal firm and the spread of trading practices between firms as managers move my research will show how the misallocation of manager skills across firms space and time can contribute to lower aggregate productivity
wide angle and resolution metrology

wooptix will upgrade to a 300mm field of view fov metrology system a readytomarket 50mm field of view wooptixs tool based on a disruptive technology that measures the phase component of a beam of light wavefront sensor with a naked sensor reaching a resolution orders of magnitude higher than other wavefront sensors this technology has been patented by the company the scalability of the solution will present an outstanding business opportunity for wooptix leading the company to achieve an amazing turnover rise our semiconductor metrology system is capable of measuring the full 300mm silicon wafer geometry with a lateral resolution of 32m and a height resolution of 03nm acquired in a single image snapshot in 100ms while capturing 15 million data points the system works by using a standard digital image sensor to acquire the intensity of the reflected noncoherent light from the silicon surface at two sperate locations along the optical path
socioeconomic empowerment of coastal communities as users of the sea to ensure sustainable coastal development

empowerus will enable coastal communities to act for change and transition towards sustainable inclusive and resilient coastal developments we assume that true empowerment implies ri should catalyze facilitate and support coastal communities in the acquisition of power through a variety of tools methods and coproduction with the inclusion of all actors at local regional national and european levels empowerus will develop an adaptive transformation mechanism via on a network of six transition coastal labs tcls across all eu coastal regions recognising that no one solution will address the myriad of challenges coastal communities face the empowerus transformation mechanism will be adaptive and based on a multiactor transdisciplinary approach the project will cocreate pilot and evaluate tailored empowerment programmes that include a portfolio of social innovation and naturebased solutions by facilitating capacity building through improved understanding of challenges barriers and enablers of change and increasing ocean literacy through nature connectedness and cultural heritage empowerus will support social innovation and selfsustaining communities the empowercoast digital twindigital gis platform will ensure the empowerus mechanism is available to all coastal communities to uptake and use to support sustainable action empowerus consortium is balanced complementary and transdisciplinary with key expertise in socio economic technical and ecological issues and the sciencepolicy needed to achieve the projects aims and objectives empowerus will provide innovative platforms to empower citizens to take transformative actions in line with eu policies to meet global challenges including biodiversity degradation and climate change at a local scale supporting just inclusive and sustainable coastal development
social media measuring effects and mitigating downsides

social media was initially expected to generate widespread improvements in individual wellbeing and to have positive externalities in the political domain such optimistic expectations soon gave way to a host of concerns about possible negative effects of social media at the societal level many started worrying that social media might exacerbate political polarization and propagate misinformation at the level of individual users many became concerned that social media might have detrimental effects on mental health especially among the youththis research proposal has two major goals first to fill critical gaps in our knowledge of the causal effects of social media on users and society second to evaluate the effectiveness of interventions aimed at mitigating the downsides of social media on the political front i will deploy a novel empirical strategy to investigate the impact of social media on political engagement and conduct a largescale field experiment to evaluate the effectiveness of an intervention aimed at increasing the quality and reducing the partisanship of the news consumed on social media on the users front i will conduct two largescale field experiments one aimed at evaluating the impact of an intervention encouraging parents to delay the acquisition of a smartphone for their children on outcomes related to child development the other aimed at evaluating whether tweaks to the social media environment can mitigate the negative effects of social media on mental healththe overarching goal of this research project is to generate new scientific knowledge on the use and impact of social media to highlight potential areas of policy intervention and to evaluate ecologically valid and scalable remedies to the downsides of social media the unique blend of cuttingedge causal inference techniques from observational data and largescale field experiments will generate insights that can benefit researchers users and policymakers alike
stimuliresponsive chiral foldamers in solution and lightemitting diodes

stimuliresponsive chiral foldamers in solution and lightemitting diodes skyfall will extend the frontier of supramolecular and materials chemistry through i the synthesis of helical fluorescent photo responsive foldamers ii identifying the physicochemical parameters governing the single or multiple helical state and assessing their impact on chiroptical properties and iii incorporating the most promising chiral fluorescent foldamers into cpoleds stereogenic centres will be introduced to the foldamer backbone to control its helicity generating a chiral environment for the fluorophores allowing for circularly polarised luminescence cpl fluorophores with a broad range of emission profiles and electron donating and accepting capabilities will be grafted to the foldamer backbone through reliable cuassisted alkyneazide cycloadditions cuaacs a photoswitch will also be incorporated to a series of foldamers generating opportunities to control hybridisation through their response to light irradiation in addition to temperature concentration and solvophobic effects the hybridisation capabilities of these foldamers will be assessed and the equilibria between single and doublestranded helices homoduplexes will be determined under the aforementioned parameters donoracceptor interactions of the appended fluorophores will be exploited to also target heteroduplexes synthesising such supramolecular structures constitutes a leap forward in the field of foldamers and more generally supramolecular chemistry providing an innovative strategy to reach cpl in the visible range the effect of these hybridisation states on the chiroptical properties will therefore be studied in solution and solidstate thin films the foldamer hybridisation states that exhibit the greatest dissymmetry values and quantum yields in the solidstate will be incorporated into cpoled devices
bringing nanospace to life by adapting pore environments to chemical complexity

the conformational flexibility and biological function of proteins is dictated by the positioning of a few amino acids into specific arrangements linked by peptide bonds we intend to implement this same principle of sequencing essential to biology to synthetic porous materials by encoding pore environments with atomic precision to control structural response and function the road to this vision remains blocked by the lack of methodologies and understanding which is required to untap the value of pore chemistry in controlling the conformational response of frameworks and encapsulated guests livingpore is structured around the complementary concepts of transformable and transformative porosity that share the use of amino acid side chain chemistry and peptide bond rotations for selecting the conformational response and function of flexible frameworks oligopeptide linkers or flexible guests small enzymes by using programmed pore settings and mutants we will develop both concepts in parallel by implementing a central highthroughput workflow that integrates computational and experimental routines for rational design and accelerated discovery these synergic multidisciplinary tools will be used to i guide chemical synthesis ii evaluate structural response and iii rationalize function all required for going beyond what can be currently achieved with conventional methods the central objective of this materials chemistry project is to lay definitive understanding on how reticular frameworks can be used to respond to transformable or select transformative specific molecular recognition patterns for cooperative selection in a crystalline solid the longterm vision is a shift in the present perception of metalorganic frameworks into unique porous materials capable of structuralfunctional responses closer to biological systems that enable distinctive applications currently unthinkable of here initially demonstrated in separation and biocatalysis
manufacturing architecture for resilience and sustainability

european manufacturing smes represent a major pillar of the eu economy but even though some of these smes are worlds champion in their own business area they are still threatened by the lack of radical technical innovation as well as successive crises of their supply chains the mars project aims to remedy to both issues by enabling smes to access advanced european breakthrough innovations in the field of aidriven digital manufacturing processes and enter into process chains that are geographically distributed specifically by gathering diverse expertise coming from complementary european partners mars will develop industry40 emerging technologies including digital twins of products processes and machines biointelligent production devices with local intelligence and high sensing coverage central intelligence with fleet learning approaches datadriven manufacturing process models from different sources blockchain technology for data hashing traceability and securitization multiagent based manufacturing planning multicriteria intelligent optimization of processes and resources especially addressing environmental footprint as a result the impact of the project will lie into introducing radical flexibility in all different aspects of manufacturing processes in particular by redefining the process route raw material resources technology throughput manufacturing site delivery date in no time while keeping up with products requirements proven product quality and sustainability of both processes and products by demonstrating its results on two case studies exhibiting advanced manufacturing processes incl homogeneous and heterogenous data mars will show how smes can decrease time delivery under difficult economical boundary conditions while targeting ambitious energysaving environmental objectives
hip at what cost how the human pelvis adapted to bipedalism and childbirth

evolutionary selective pressures have shaped the human skeleton for millions of years contributing to its distinctiveness compared to other primates among all the elements of our skeleton that have undergone huge modification arguably one of the most distinctive ones is the pelvis the pelvis plays a pivotal role in reinforcing the skeleton against external forces during locomotion and as such selection pressures have acted particularly on it however efficient bipedalism came at a cost when balancing other selection pressures as a result the difficulty of childbirth has been constant during human evolution today obstructed labour is the cause of 8 of maternal mortality a deep analysis of the biosocial dynamics that act from birth to adulthood is fundamental for a complete understanding of pelvic anatomy such a developmental perspective on the pelvis anatomy is currently missing risen aims to fill this gap by extensively exploring the mechanisms that lie behind pelvic development unravelling how when and to what extent external influences eg bipedalism health status affect adult bone morphology thanks to the proposed innovative and multidisciplinary methodology that leverages cuttingedge technologies and brings together biological and cultural data risen 24 months usa 12 months italy will produce a comprehensive investigation that will have a huge impact on contemporary society or public health issues related to womens lives this international and interdisciplinary project will give the fellow a full background and foster scientific expertise to accomplish a project as ambitious as risen this project responds to eu research priorities through the transfer of gained knowledge and partnerships development with leading experts not only does it improve employability and career prospects but also contributes to the eus competitiveness and growth