Dragon09/odtu_chatbot huggingface dataset:
safe system for radical improvement of road safety in low and middleincome african countries

the primary objective of the afrosafe project is to make a significant progress in propagation of the safe system modus operandi within the road safety work context in african countries this is reached by exposing the local practitioners and decision makers to the stateoftheart knowledge and practices within road safety management based on safe system principles as well as supporting them by sharing necessary knowledge tools and methods for road safety improvementadjusted to the african conditions and in tight cooperation with the local actors more specifically this is reached through mapping of the existing regulations procedures methods and tools within all five pillars of road safety management safe infrastructure safe vehicles safe road users and postcrash care development of the recommendations for improvements and running a series of pilots and demonstrations to illustrate these recommendations in action in these activities the problems and needs of the vulnerable road users will receive particular attention another focus area for the afrosafe project is capacity building through education of the local educators in all areas relevant for road safety together with them the current curriculums are revised new educational programmes created and an educational platforma virtual centre of excellencewill be created
onchip integration of quantum electronics and photonics

a major roadblock for siliconbased optoelectronics and its quantum applications is that conventional cubic silicon has an indirect band gap and hence it is optically inactive onchips will capitalize on a recent breakthrough from within its consortium growth and optical characterization of a revolutionary new material hexagonal germaniumsilicon hexgesi which is a siliconbased optically active directbandgap semiconductor building on this discovery onchips key objectives are as follows 1 we will for the first time grow advanced hexgesi heterostructures for quantum technology applications 2 we will realise spin qubits in quantum dots in hexgesi 3 we will create spinphoton interfaces in hexgesi made possible by the direct bandgap of the material 4 we will build singlephoton detectors for wavelengths beyond 2 micrometers optimized for emission from hexgesi this project is well aligned with the scope of the call and will foster the integration of electronic and optoelectronic functionalities based on a siliconbased directbandgap semiconductor using a combination of facilities and expertise that is available only in europe hence onchips will establish a strong contribution to european innovation leadership in electronics photonics emerging enabling technologies in general and quantum technologies in particular making our contributions highly relevant for the work program this new material has the potential to be compatible with standard siliconbased semiconductor technology benefitting from established roadmaps on miniaturization and scalability
rna structure ensemble dynamics in living cells

ribonucleic acid rna is a ribonucleic acid rna is a jackofalltrades it orchestrates and contributes to a multitude of essential cellular processes both under physiological and pathological conditions among these transcriptional and posttranscriptional regulation of gene expression splicing and translation controlmany of the functions of rna rely on its ability to fold into stable secondary structures however rna structures are far from being static indeed for a given rna multiple alternative structural conformations can coexist as part of a heterogeneous and dynamic ensemble crucial to the regulatory functions of rna structures is their ability to dynamically redistribute the relative abundance of specific conformations within the ensemble in response to environmental cues despite its ascertained importance the study of rna structural dynamics in living cells has largely remained elusivethe goal of this ambitious proposal is to provide a deeper understanding of the mechanistic aspects underlying rna structural dynamics in living cells and thereby to comprehend the regulation and mechanism of action of rnas in other words how are changes in the structure of an rna triggered and how do these changes reflect on the cells phenotype by combining cuttingedge experimental and computational methods many of which developed in my lab my team will i explore how rna secondary structure ensembles dynamically change in response to environmental cues ii investigate how rna posttranscriptional modifications and editing contribute to and control rna secondary structure ensemble dynamics iii characterize rna secondary structure ensemble dynamics at transcription and their contribution to splicing regulationby dissecting the role of rna secondary structure ensemble dynamics in finetuning gene expression the pioneering research here proposed will fill an important gap in our understanding of the mechanisms of gene regulation in cells
carbon atlantis project to undo residual emissions construction and deployment of a minimum viable product the gen3 stack capable of capturing 500 tonnes co2 per year from the air

without carbon removal humanity will struggle to achieve carbon neutrality the ipcc estimates that 6 gigatonnes of co2 will need to be removed by 2050 to limit global warming to 15c biobased solutions are relatively affordable but have limited scalability technological solutions have recently been developed but remain several orders of magnitude too expensive for mass market uptakecarbon atlantis have developed a breakthrough electrolyser that can decrease the costs of co2 capture to below 75tonne at megatonne scale the objective of capture is to finalise the development of the third iteration of our technology gen3 and to deploy it in a demo plant successful deployment will validate the gen3 500tco2year minimum viable product in front of investors and customers enabling us to raise funding to build out a mass manufacturing line we aim for our devices to be capturing over 500000tco2year by 2030 with a vision is to remove 100 megatonnes of co2year by 2045
quantum computing and its calculi

quantum computing can be thought of in multiple ways among those ways it can be seen as a computational model of quantum mechanics studying this model may have implications for our understanding of physics it can also be seen as a new computational paradigm with implications for computation algorithms and logic additionally it can be viewed as a computational device that requires programming therefore it is necessary to design and study programming languages for this purpose the study of the foundations of quantum programming languages type theory and logic through the curryhoward correspondence may shed light on our understanding of quantum mechanics furthermore it may lead to the development of new logics or the understanding of new structures in classical logic lastly implementing these languages will enhance the way we program the new computers when they become widely usedin this project we propose to study these various aspects of quantum computing specifically focusing on the foundations of programming languages
dissecting the role of rapid auxin responses in plant morphogenesis

plant cells living in their cell walls are immobile and thus tightly control growth to shape their organs and bodies mechanical properties of the cell wall are modulated by ph which is governed by the activity of plasma membrane proton atpases the central regulator of plant growth phytohormone auxin regulates gene transcription my team and i have significantly contributed to recent discoveries of additional auxin signaling pathways that act rapidly in a nongenomic manner surprisingly all auxin signaling pathways converge on the regulation of ion fluxes and cell wall ph the central hypothesis of the morph project is that the rapid regulation of cell wall ph by auxin plays a fundamental role in plant development i propose that rapid auxin responses controlled by the tir1afb auxin receptors participate in the morphogenesis of the aboveground plant body and that these receptors also drive rapid responses in grassesin this project i will reveal the identity of molecular components of the afb1driven cytoplasmic auxin pathway using a forward genetic screen and protein proximity labeling approaches exploiting the unique genetic material of my team i will address the role of the rapid cytoplasmic auxin responses in the development of aboveground organs of the arabidopsis model plant by embracing a new model system relevant to cereals brachypodium distachyon i will elucidate the significance of rapid auxin responses in grasses finally using a combination of livecell imaging proteomics and genetics i will analyze and manipulate cell wall ph dynamics during key plant morphogenetic events and discover the regulatory mechanisms underlying cell wall acidificationthe morph project will uncover novel fundamental roles of rapid auxin signaling in morphogenesis and at the same time will expand my research toward plant models relevant to cereal crops
the mosaic design strategy application to underwater acoustic functionalities

the mdsappthe mdsappuaf action is supervised by professor vicente romerogarca at instituto universitario de matemtica pura y aplicada iumpa at universitat politcnica de valncia upv spain this proposal is on the implementation of a novel mosaic design strategy to the fabrication of an underwater acoustic impedance tube prototype as well as the realization of an underwater acoustic absorber with a broadband absorption spectrum and thickness that can surpass the causal constraint the proposed project combines theoretical modelling simulations and experiments the successful completion of this project can have commercialization implications with the attendant effect of propelling the research and development activities in the underwater acoustics area the proposed action is seconded by the laboratoire dacoustique de luniversit du mans at le mans universit laum laum represents one of the largest acoustics laboratories in the european union therefore it will complement the mathematical and physical skills provided by iumpa with the acoustics and mechanics needed for the project both iumpas and laums activities range from basic research to industrial collaborations with connections with many of the leading universities and research institutions in europe both offer an ideal environment for the successful completion of this proposed project including scientific management dissemination and exploitation activities and its subsequent trials prior to commercialization considerations this intersectoral and interdisciplinary action is also actively seeking cooperation with european acoustic companies aims to extend the development of underwater acoustics in academic research and industrialization it would also contribute to broadening the applicants horizon in the european research area strengthening her multidisciplinary skills to grow into a mature researcher and enhancing hosts international influence in the relevant fields
irish identities and political thought in early modern historical writing greek and roman sources

current political debates relating to brexit the northern ireland protocol and the integration of the republic of ireland into the european union which reveal the pluralism of irish identities including european nationalist and unionist visions can be traced back to seventeenthcentury reflections on conquest stateformation the reformation and colonial plantations in ireland this project investigates two foundational pieces of the seventeenthcentury irish historical writing the irishlanguage foras feasa ar irinn by geoffrey keating 15801644 and the neolatin cambrensis eversus by john lynch 15991677 their narratives defended the history of ireland from claims by the twelfthcentury historian giraldus cambrensis about the barbarous nature of the irish people which were utilized by his early modern followers to justify the english conquest of ireland in the sixteenth and seventeenth centuries the project asks how and why early modern irish authors exploited the cultural capital of classical rhetoric history and political thought through both irish and latin in order to fashion a distinct representation of irish history which underlined connections between ireland and britain as well as between ireland and europe the results of the study will impact current understanding of the varieties of irish national discourse as the irish republic reflects on a centenary of independence from britain and on a fiftieth anniversary of its membership of the european communities the proposed research would be carried out at aarhus university which excels in interdisciplinary research on european literature and culture including classical languages and culture and their reception in ireland au university will enable me to update my expertise in early modern irish and neolatin languages and in classical reception which is necessary for the completion of this project
mending sex differences unravelling the female predominance in pulmonary hypertension

pulmonary hypertension ph is a rare but progressive fatal disease characterized by accumulation of persistently activated cell types in the pulmonary vascular wall exhibiting abnormal expression of genes driving proliferation inflammation and metabolism the currently used vasodilatory therapies have little or no impact on this activated phenotype and therefore offer no cure or even substantial survival benefit ph has a high female predominance 31 to 91 this proposal aims to understand the mechanism behind the high female predominance to identify novel therapeutic targets to attenuate disease progression in male and female ph patients female predominance can be linked to sex hormones andor incomplete x chromosome inactivation xci leading to biallelic expression of immunoinflammatory and metabolic genes to understand the impact of oestrogen and androgen signalling on abnormal vascular remodelling in ph i will develop a unique oppositesex lung transplantation rat model identify oestrogen metabolites in a large set of patient serum samples and explore their biological relevance using pulmonary vascular cells from male and female ph patients in cellbased assays preliminary experiments suggest there is incomplete xci in ph i propose to combine sequencing and molecular studies to extensively characterize the impact of incomplete xci on the physiology of male and female pah cells and identify genes and druggable targets regulating incomplete xci in ph finally i will explore a novel pulmonary endotheliumspecific drug delivery method to deliver identified promising genescompounds to selectively inhibit the activated pulmonary vasculature thereby minimalizing side effects compared to current delivery methods together this high riskhigh gain study will dissect the molecular mechanisms underlying the unresolved female predominance in ph and offer novel pulmonary endotheliumspecific therapies for both male and female ph patients
data ownership platform turning privacy laws from an obstacle to an opportunity

groundbreaking innovation of the underlying systems upon which our society is built cannot be enacted by fitting new facts into old schemes disruptive solutions require a paradigm shift that could be paralleled to a copernican revolution of our time the revolution id like to see unfold is the introduction of a new decentralised and distributed data economy ecosteer an iot and blockchain startup for data ownership and monetisation i cofounded aims at doing precisely that data is rapidly becoming the sustenance fuelling economic growth and innovation yet its economy is utterly asymmetrical and controlled by a handful of tech giants moving away from a centralised approach where digital platforms that collect consumers data have exclusive control over third party access ecosteer data ownership platform technically implements a decentralised vision where each consumer can directly control visibility over her data by each individual third partybased on a patented multicast endtoend encryption scheme and smart contracts the dop adds a layer of data access control decentralization on top of any existing data brokering platform transforming it into a neutral and blind data intermediary consumers can unilaterally grant revoke access to their iot data streams to selected third parties and be compensated in tokens for data sharing thus promoting data altruismdecentralisation of the data economy as well as availability of the means for everyone to become an active stakeholder be it a business or an individual ensures that the market is dynamic inclusive and heterogenous more participants to the data economy mean more opportunities for data monetisation steeper and quicker economic growth and sustainable datadriven decisionsecosteer dop thus enables european companies to become the leaders of a new data economy based on the ethical principles established by the gdpr
mitigating transportrelated air pollution in europe

air quality in urban areas and other hot spots where transport emissions induce a large impact on human exposure remains an environmental problem of high complexity with strong public interestdespite the significant improvements achieved adverse health effects are found to be of high concern there is strong evidence that despite strict emission standards real world emissions is accepted as term indicating a status of partial success of these measures and technological advances in fossil fuel emission control while new sources such as nonexhaust emissions and micro plastics are becoming significant a large level of uncertainty arising from the assessment and mitigation of these sources and especially the internal combustion engines arises from their physicochemical transformation from the tailpipestack to the ambient environment the metrics and parameterization employed on the data analyzed from the environmental monitoring networks and measurement systems are poorly representing the material initially emitted by the specifications of these engines certified by the manufacturers and the control legislationit is therefore difficult to link the health and other environmental effects to specific sources or modes of transport with few exceptions human exposure dosimetry and burden of disease modelling will be assessed the output will be linked to epidemiological studies across europe and a specific epidemiological product of the extracted impact due to transport will be soughtthe project will provide innovative means in terms of monitoring devices and schemes of data analysis and management and a network of monitoring stations close to transport emission hots in order to remedy the traceability of the emitted pollutants from transport sources to the atmosphere and the assessment of applied legislation and control measures through a mitigating solution toolbox
what is controlling plate motions over the minutes to decades timescale

tectonic ground observations from global navigation satellite systems gnss increasingly show that plate motions are nonsteady in some instances these nonsteady motions have been suspected as precursory motions to large earthquakes however the full spectral behaviour of transient plate motions across minutes to decades and kilometres to continental distances is not well understood here i propose a multipronged approach to study how faults and plates worldwide are moving in response to the geodynamical interior and geophysical fluid loadingtidal exterior boundary conditions the major questions to address are how transient is tectonic deformation over the minutes to decades timescale what are the physical processes controlling the transient plate motions to what extent are transient plate motions indicative of earthquake imminence we will reveal the extent of nonlinear tectonic motions by developing gnss processing algorithms and applying these to data from the thousands of tectonic gnss stations worldwide with machine learning numerical modelling and laboratory experimentation we will determine to what extent faults are modulated by variable regional tectonics and loading we will develop kinematic and laboratory modelling strategies to better understand transient tectonic boundary conditions such as transient slabpull at subduction zones while analysis will span continental and global scales we will also investigate the kinematics of faults and fault networks with dense gnss observations at a higher resolution using gnss and seismic data from northcentral chile as well as from laboratoryscale analog modelling to track fault failure in unprecedented detail in greece a worldclass example of a seismically hazardous zone of faultnetwork complexity we will set up a worlds first lowcost tectonic gnss network to understand how microplate motions interact with the larger wavelength tectonic boundary conditions of the region
electron nose acquisition and modification of hierarchically nanostructured oxide active materials for advanced biological gas sensor

the project represents a pioneering endeavor in the realm of gas sensor development harnessing the latest advancements in powder nanotechnologies and adopting a holistic multidisciplinary scientific approach by pushing the boundaries of current sensor capabilities the project aims to create a new generation of gas sensors that excel in sensitivity and response time outperforming existing prototypesthrough the intricate integration of multiparametric signal processing algorithms and stateoftheart nano powder metaloxide sensors the project endeavors to fabricate miniature devices akin to an electronic nose these devices will not only mimic the sophisticated capabilities of biological analogs but also exhibit a high level of component integration setting new standards in sensor technologyfurthermore the projects scope extends beyond mere sensor development it envisions the creation of a novel global security system leveraging the envisioned sensors embedded within mobile communication devices this innovative system holds the promise of revolutionizing security measures by enabling highly localized detection of various threats including epidemic outbreaks fires and terrorist activities as a culmination of these efforts the project aims to generate patentable outcomes ranging from novel sensor materials to groundbreaking analytical methodologies these outcomes have the potential to drive significant advancements not only in sensor technology but also in the broader fields of security and public health monitoring