Dragon09/odtu_chatbot huggingface dataset:
promoting robust systems biology on patients and experimental models with obesitydriven liver cancer

in obesity pathological expansion of adipocytes leads to increased adipose tissue macrophage atm amounts and adipocyte death adipocyte death in turn is linked to ectopic lipid spillover and metabolically triggered inflammation which is a risk factor for diseases such as cancer particularly hepatocellular carcinoma hcc that is linked to nonalcoholic steatohepatitis nash hepatic fat accumulation leads to chronic hepatocyte metabolic and oxidative stress resulting in cell damage and death although oxidative damage microbiome dysbiosis mitochondrial dysfunction sterile inflammation are important in promoting nash and fibrosis and cirrhosis are crucial for hcc development the exact triggers remain unknown in hcc tumor cells take up nutrients including lipids to support their proliferation and solid tumors in hcc are characterized by enhanced hypoxia and acidosis resulting from a locally modified metabolism beyond malignant cells the tumormicroenvironment tme contains immune cells including tumorassociated macrophages tams and dendritic cells tams are pro tumorigenic sabotaging antitumor immunity through various mechanisms notably tams tumoursuppressive phenotype is directly linked to their lipid loading and disrupting lipid formation in tams attenuates tumor growth further in the tme dendritic cells are triglyceride laden which contributes to immunosuppression by impairing their ability to present antigen despite advancements a systems approach to understand the exact metabolites and lipid species in obesity driven hcc remains a challenge moreover which metabolites are adipocytederived or locally produced within the liver remains unclear here using systems biology coupled to nash and nash driven hcc animal models as well as patient cohorts spanning the nafld nash and hcc spectrum we aim to identify which factors produced by adipose and the liver regulate obesity driven hcc and contribute to immunosuppression
towards democratic landscape observation through geoinformatics and public participation

landscape is a key element of individual and social wellbeing although its protection management and planning is acknowledged by the european landscape convention of the council of europe since 2000 not much has been done for this treatys comprehensive implementation topio aims to give people an active role in decisionmaking on landscape by means of citizen science geoinformatics earth observation and gis artificial intelligence and public participation to promote the areas sustainable development topio will position the landscape as a key concept in addressing broader challenges such as the faro convention plan aarhus convention un sustainable development goals the eu green deal etc it will provide innovative international interdisciplinary and intersectoral training for the researchers of topio partners based on training activities and mobility actions in a range of different disciplines achieve advanced innovation and capacity building through developing a research and training network that will focus its activities on developing effectively integrating and increasing utilization of existing and emerging landscape monitoring techniques reinforce the sociocultural and environmental dimensions of the landscape and its role in defining operative and integrative frameworks supporting sustainable development at local and regional levels through the application of landscape character assessment methodologies in seven european countries exchange information on landscape policies and peoples experience concerning protection management and planning public participation and implementation at different scales and levelstopio will integrate and synthesize project findings suitable for awareness raising readily communicable to a wide audience and relevant for policy negotiations furthermore the project will maintain a dialogue with relevant stakeholders and will provide recommendations for policy makers
intelligent twinning of wireless networks for 6g

new emerging applications demand performance requirements that exceed the capabilities of 5g networks requiring a rapid evolution towards 6g networks 6g is expected to offer data rates of the order of tbps time responses of the order of submilliseconds and localization accuracies of the order of subcentimeter while meeting united nations sustainable development goals this calls for the deployment of paradigm shifting technologies and design methods and the use of new frequency bands including the deployment of reconfigurable metamaterial transceivers the integration of communication and sensing functionalities and the migration towards the subterahertz spectrum this will make 6g an extremely complex system to model and optimize digital twins dts and machine learning ml are two vital technologies to tackle the modeling and optimization complexity of 6g a dt is a virtual replica of the 6g physical network dts are essential to model complex systems in real time providing valuable insights into their behavior and performance as well as for generating enormous amounts of training data ml provides advanced analytics and decisionmaking capabilities enabling 6g communication systems to selfoptimize selfconfigure and selfheal the integration of dts and ml offers a powerful approach for modeling simulating and optimizing 6g communication networks it is expected to lead to the creation of a highly intelligent and dynamic network environment where physical and virtual objects interact seamlessly and where decisions are made and executed in real time twin6g is the firstofitskind staff exchange research and transferofknowledge program whose aim is to build the worlds first openaccess and opensource digital twin emulator to design 6g networks integrating accurate physical models for emerging technologies and physicsbased ml designs for dynamic and realtime network optimization
validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases

fibrostenosis is the driving reason for the persistent need in bowel resections in inflammatory bowel diseases ibd current ibd therapies are limited to solely targeting inflammation while these therapies in some but not all cases lead to symptomatic disease remission recurrent flares interspaced with periods of remission will still result in cumulative gut wall remodeling and fibrosis indeed despite these therapeutic strategies to control inflammation fibrostenosis incidence and bowel surgical resection is not declining in ibd patients as no antifibrotic drugs are currently available the aim of this project is to validate fibroblast therapeutic targets for preventing andor treating fibrosis in ibdpatientsamples with an emphasis on c3 andor tyk2stat3 andor nlrp3 in the evolution of intestinal fibrosis the antifibrotic efficacy and mode of action of these novel immunotherapies will be studied preclinically in ibdpatient derived samples and validated in animal models of chronic colitis in parallel we aim to develop and validate a clinical diagnostic and prognostic pathway for fibrosis in ibd patients based on the use of noninvasive crosssectional imaging techniques such as magnetic resonance enterography with elastography and optoacoustic these results together will allow to design a firstinhuman proof of concept randomized trial of immunotherapeutic drugs targeting complement c3 andor tyk2stat3 andor nlrp3 pathways in intestinal fibrostenosis our aim is to obtain patients and regulatory approval for implementation of these novel noninvasive imaging modalities as diagnostic and prognostic tools for fibrotic ibd to allow vital future therapeutic development for intestinal fibrosis by providing better molecular and clinical stratification of ibd patients at risk for fibrosis and by identifying and validating novel targets for antifibrotic therapy we aim to pave the way in preventing and treating this invalidating ibd comorbidity
molecular mechanisms through which oocytes evade ageing

female germ cells oocytes have the remarkable ability to survive for long periods of time up to 50 years in humans while retaining the ability to give rise to a new organism we know surprisingly little about the molecular mechanisms through which oocytes alleviate cellular ageing and why such mechanisms eventually fail with advanced age the goal of this research proposal is to reveal both the mechanisms dormant oocytes employ to maintain cellular fitness and how ageing affects these mechanisms combining biochemical perturbations with imaging and stateoftheart omics techniques we have recently discovered that oocyte dormancy involves two mechanisms not reported in any animal cell type before the suppression of mitochondrial complex i and the constitutive activation of mitochondrial unfolded protein response these discoveries point to a set of poorly understood strategies that oocytes use to minimise damage to their cellular components during their long lifespan in this project we focus on three new interlinked directions to reveal mechanisms that dormant oocytes employ to keep a youthful cytoplasm 1 characterise the metabolic adaptations that enable life without mitochondrial complex i 2 study extremely longlived oocyte proteins and their regulation 3 identify and characterise the quality control mechanisms that eventually fail in dormant oocytes to impact fertility we will use oocytes from frogs mice and humans which are complementary in their ease of handling and relevance to human physiology one of the biggest problems developed nations face is latemotherhood and associated fertility problems due to ageing oocytes 25 of female fertility problems are unexplained pointing to a huge gap in our understanding of female reproduction this proposal will help fill this gap by studying longevity mechanisms in dormant oocytes it will further provide insights into the metabolic adaptations of longlived cells female fertility and ageing
dynamic regulation of photosynthesis in lightacclimated organisms

cultivation of plants consumes huge resources of water for irrigation and energy for lighting introducing disruptive technologies is key to improve plants and enable their parsimonious cultivationdream overtakes these challenges by gathering an interdisciplinary consortium sharing a same radical vision to measure and exploit the dynamics of photosynthesis regulation under naturallike light conditions for selective sensing monitoring the plant state and enhancing lighting efficiency in controlled environments we develop groundbreaking instruments and acquisition protocols unraveling unprecedented kinetic data from microalgae and plants including tomato as a crop species by using novel periodically modulated or randomly fluctuating illuminations chlorophyll fluorescence and original luminescent nanosensors these data are processed with comprehensive theoretical tools system identification dynamical systems system control machine learning to build a powerful dynamical model which delivers categorizing fingerprints for highly selective sensing and tailored modulated illuminations for enhancing lighting efficiency finally we implement a server with incremental learning from an open source community to extend sensing to organisms and environmental conditions much beyond the ones used in our dream projectdream will expand knowledge on photosynthesis regulation and lead to major achievements categorizing plant states sensing stresses selecting improved plants improving controlled ecosystems equipping lighting with sensing and decreasing its cost and instrument design targeting scientists and many more endusers dream will further improve innovation in key european industries active in the fields of scientific instruments phenotyping and plant production while increasing resource use efficiency so as to improve environmental quality and offer better and safer products to consumers
modelling of threephase flows with catalytic particles

this proposal is on modelling of 3 phase gassolidliquid multicomponent flows with catalyst particles which are frequently encountered in industrial applications but have not been tackled fundamentally before due to their complexitydense multiphase flows have been intensively researched because of their scientifically interesting transport phenomena and industrial applications considerable progress has been made for gassolid and gasliquid twophase flows however catalytic multicomponent threephase flows have received relatively little attention despite their importance for the production of clean synthetic fuels base chemicals and many other products multiphase transport phenomena in such systems are poorly understood due to their complexity therefore the design of processes is cumbersome in addition the process operation is often far from optimal in terms of energy and feedstock utilization therefore significant improvements are required to boost the efficiency of threephase systems which demands for a better understanding of the transport fundamentals and complex interplay with chemical reactions and availability of predictive toolsthe main underlying problem is the wide range of length scales suspended catalyst particles have a size of 100200 m whereas the diameter of industrial reactors is 510 meters to tackle this problem a multiscale modeling strategy is required at the finest scale detailed models take into account the interaction between the phases these interactions are condensed in closure laws for mass momentum and heat exchange that feed socalled eulerlagrange models which can then be used to compute the flow structures on a much larger industrial scale the key innovative aspect of this proposal is the integrated approach including incorporation of multicomponent chemical transformations and the validation on basis of onetoone comparison of the of the computational results with experiments
aligning and mutualizing nonprofit open access publishing services internationally almasi

the objective of almasi is to provide the research community with an aligned nonprofit highquality and sustainable scholarly communication ecosystem across three world regions africa europe and latin america this will enable scholarly communities to take full responsibility for innovative valid reliable and accessible publishing services and solutions that do not charge fees to readers or authors commonly known as diamond open access this aligned nonprofit publishing ecosystem will take into account specific needs across the diversity of disciplines global regions and languages the project will achieve this goal by concentrating on measures that will harmonise and strengthen existing nonprofit publishing services and solutions almasi will establish a framework for knowledge transfer coordination and alignment of nontechnological publishing skills services and solutions the project will focus on 1 mapping nonprofit publishing services and solutions across the 3 regions 2 aligned quality support instruments for publishing services 3 shared training materials and curricula for publishing services journal editors and publishing staff and 4 longterm financial sustainability and os policies for scholarly publishing the project will be carried out in the context of the nascent global diamond federation which is supported by unesco
cacheaided folding for reducing vod loads in networks

communicating videoondemand vod over various networks is very costly vod drives up the costs for purchasing bandwidth and overprovisioning infrastructures as well as the costs to content providers netflix amazon etc that must pay large fees to network operators to deliver content to their clients to reduce the massive vod fees networks employ caches our findings in our erc project duality reveal a new method of exploiting caches that boosts the performance of various networks we wish to explore the practical ramifications of these findings in practical networks this project will explore the algorithmic and testing work needed to render these ideas practical
empowering personalized therapeutics advancing 3dnano dld arrays and raman microbiochips for precision isolation segmentation and molecular profiling of exosomal trop2 biomarkers in tnbc

the exodiagai project is at the forefront of addressing a critical challenge in modern healthcareearly diagnosis and effective management of breast cancer particularly the aggressive and elusive triplenegative breast cancer tnbc subtype tnbc lacks welldefined molecular targets hindering treatment options exosomes a subset of extracellular vesicles with unique functions hold great promise as diagnostic and prognostic markers for various diseases including cancer these tiny vesicles are abundant in biological fluids but have been underutilized due to the absence of a costeffective isolation protocol our primary goal is to develop a microfluidic device integrating nanolateral displacement arrays with a raman biochip to identify exosome biomarkers specific to tnbc and translate this knowledge into clinical practice this projects main objectives encompass creating the microfluidic device assessing its surfaceenhanced raman spectroscopy sers capabilities conducting raman fingerprinting of exosomes from in vitro cell cultures and patient samples and employing chemometric analysis to discriminate biomarkers the distinctive raman fingerprinting associated with exosomes serves as a promising prognostic and diagnostic marker by introducing 3d printing sers technology we aim to enable realtime monitoring shedding light on exosome structural integrity this interdisciplinary project combines organic inorganic nano computational spectroscopic and molecular biology techniques culminating in innovative device fabrication ultimately the exodiagai project holds the potential to revolutionize early breast cancer diagnosis through exosomal biomarkers aligning with the eus sustainable development strategy for advanced diagnostic platforms and fostering the career of a promising researcher this endeavor marks a pivotal step towards enhancing the detection and management of tnbc addressing a pressing healthcare need
piezomagnetic ferrites for selfbiased nonreciprocal millimeter wave devices

the relentless demand to increase data rates traffic and connected devices in our mobile communications has prompted a paradigm shift in wireless technology 5g and the forthcoming 6g will use mmwaves and miniaturized antenna systems that need to be lowcost and energetically efficient an unresolved challenge of this transition is the miniaturization of nonreciprocal devices above 100 ghz pi4norm envisions an onchip integration of miniaturized selfbiased nonreciprocal magnetic components for the forecasted 6g evolution those passive devices are significant components fulfilling three critical functions within rf systems decoupling amplifiers protecting the systems against mismatched impedances or electromagnetic aggression and enabling the fullduplex operation of antennas pi4norm aims to fill the gap between materials science and mmwave engineering to develop subthz ultracompact selfbiased nonreciprocal elements the success of pi4norm could open an expansive innovation roadmap toward more capable rf systems and radar for this reason a strategic transfer strategy is also implemented in pi4norm
regulating rnapii levels gaining insight into the translation assembly and transport of rnapii subunits

cellular diversity in eukaryotic organisms is obtained through differential regulation of transcription which is therefore a heavily studied step in gene expression proteincoding genes are transcribed by rna polymerase ii rnapii an enzyme consisting of twelve subunits recently work from my host lab the svejstrup lab has suggested that depleting the number of fully assembled rnapii molecules in the cell through degradation of its main catalytic subunit rpb1 is crucial for achieving transcription recovery after dna damage this finding underscores the importance of understanding how rnapii levels are regulated therefore in this proposal i aim to gain insight into the mechanisms influencing rnapii abundance by studying rpb1 mrna and protein levels rnapii assembly and rnapii transport in human cells specifically i will leverage my background in rna biology and bioinformatics analysis to identify rnabinding proteins interacting with the 3utr of rpb1 and study their role in regulating rpb1 mrna turnover and translation efficiency moreover using stateoftheart selective ribosomal profiling techniques i will determine whether rnapii is assembled cotranslationally as was recently proposed to be the mechanism of assembly for most multisubunit complexes in eukaryotes finally i will perform a crisprcas9 screen to identify novel factors that mediate rnapii nuclear import together this proposal will elucidate the biogenesis of rnapii which is crucial for a better understanding of transcription regulation the proposed experiments will enhance my postdoctoral training by broadening my conceptual and technical skills and will provide data and tools to start my own laboratory in the future ultimately these findings might also have therapeutic implications as rnapii is one of the targets being investigated for cancer treatments
catholic inculturation of the uniate church basilian hagiography of the 17th and 18th centuries

in early modern period the longlived rift between catholicism and orthodoxy was overbridged by the union of brest 1596 it established the uniate church in the region reaching from lithuania through poland and belarus to ukraine and it was the basis for the development of local monastic structures the basilians while the research on uniate and basilian literacy significantly underrepresented in an international discourse on posttridentine christianity and its culture is interested mostly in basilian book and printing history basincult pursues for the first time a detailed and qualitative analysis of the writings about the saints and candidates to sanctity hagiography who had a programmatic and symbolic meaning in a wide spectrum of literary forms created and circulated in the 17th and 18th centuries it is argued that the uniates and basilians used hagiographic sources not only to adapt uniate church to the framework of the catholic culture but especially to include their issues in the mainstream of catholic discourse focusing on the instructive examples of saint figures eg josaphat kuntsevych works eg menologium bazyliaskie and hagiographers who served also as orders officials ignacy kulczyski the project demonstrates the strategies of such a mutual adaption process regarded as inculturation which had a vast impact on shaping the confessional and cultural landscape of todays centraleastern europe the project will be affiliated at vilnius university in an exceptional environment of the specialists in uniate history and basilian monasticism