Dragon09/odtu_chatbot huggingface dataset:
polished stone tool biographies and their social and economic impact in the aegean neolithic

this project explores the emergence of value and wealth as a concept in human history social and economic changes accelerated during the neolithic but until now it remains unclear what triggered inequality in these communities thus the project aims to nuance how inequality evolved in human history to approach this key question the study will investigate social and economic transformations initiated by the appearance of polished stone tools axes adzes chisels and wedges recovered from neolithic sites burials households and quarries from the 7th to the 4th millennium bc in the aegean the project hypothesis is linking the neolithic human awareness of raw material availability and biographies of polished stone tool assemblages with the abstract concepts of the different kinds of value and wealth in these communities the project will pursue its objectives by initiating four work packages which will for the first time document and compare polished stone tools made of rare jadeitite nephrite omphacitite or eclogite and common serpentinite andesite basalt gabbro and hematite raw materials from sites burials and households in selected synchronic and diachronic case studies by revealing the location of previously unknown raw material sources and quarry sites of polished stone tools the project will be able to discover the interrelations between local regional and superregional exchange networks through technomorphological usewear and contextual analysis of polished stone tools it will be possible to qualify and quantify the different stages of the studied objects from procurement manufacture and usage to the final deposition the data from the polished stone tool assemblages will be related to other materials lithics ceramics bones shells obsidian flint copper and gold from the studied sites burials and households in order to identify new aspects related to the value of objects and fluctuations in wealth and inequality
graphs and ontologies for literary evolution models

the graphs and ontologies for literary evolution models golem project will create statistically robust models explaining how fiction evolves based on the analysis of millions of stories and the effects they have on readers this is the first time in history that this kind of data is available on such a large scale thanks to the fact that readers all over the world use digital and social media to share fictional stories and to comment on them eg on fanfiction websites or on publishing platforms like wattpad golem will use computational literary studies and cultural evolution theory to create accurate models of how the formal and contentrelated cultural traits found in fiction spread and combine the basis of this evolutionary analysis of fiction will be a knowledge graph database an infrastructure of interlinked data about stories and reader response which will be used to test hypotheses related to the accumulation of cultural traits in stories and their effectiveness in achieving cognitive and emotional effects on readers stateoftheart machine learning algorithms and advanced statistical modelling tools will be employed to create a major breakthrough in computational literary studies possibly also contributing to the revision of cultural evolution theories by focusing on the relations between stories in five different languages collected from countries in all continents golem will provide an unprecedented insight into how storytelling one of the most ancient cultural systems evolves literary history and criticism have offered refined accounts of how fiction works mostly relying on case studies of limited extent it is now time to provide robust statistical evidence of the anthropological function of fiction and of how it adapts to different circumstances and cultures empowering readers to cope with their cultural or societal contexts
future instrumentation and control based on innovative methods and disruptive technologies for higher safety level

the longterm operation of nuclear power plants npps calls for innovative methods to monitor the ageing of safety systems new instrumentation will also lead to improve decisionmaking in accidental conditions thanks to additional information complementing the material and organisational modifications decided after the fukushima accidentthe project find aims first to adapt innovative technologies deployed in other industries to prevent the failure of metallic pipes find will work on structural health monitoring technologies ultrasonic guided waves and acoustic emission to detect defects in real time during plant operation even in inaccessible locations in addition digital twins will be developed to better predict degradation phenomena with combination of detailed mechanical models and real plant data strain temperature and vibration measurements tests in experimental and industrial conditions including npps will be performed representative of the following phenomena local corrosion and large deformations of raw service water pipes stress corrosion cracking and fatigue on the primary circuit flow accelerated corrosion on the turbine extraction lineconcerning accidental instrumentation find will first develop systems to track water movements during a lossofcoolant accident this will include localisation of breach thanks to heated thermocouples and data science approaches find will evaluate feasibility to monitor progression of severe accidents thanks to analysis of fission products in containment either by gamma ray spectroscopy or physicochemical analysistechnologies developed in find are low intrusive and cost effective they will help to anticipate maintenance and will complete or replace some nondestructive testing this will result in higher availability of npps lower operator dosimetry and reduced costs which will foster their adoption find is led by irsn french public expert for nuclear risks and encompasse
assessing the codissemination of virulence and antibiotic resistance genes in resource recovery applications

the secret behind a successful pathogenic bacteria lies on achieving the perfect balance between virulence and resistance virulence genes vgs and antibiotic resistance genes args can be colocalized in the same mobile genetic element and thus can be transmitted together in a single horizontal gene transfer event in the last decades the number of bacteria carrying vgs and args has increased significantly and their dissemination is amongst the greatest global threats to human health these genes are released into the environment during the discharge of treated wastewater and via the recycling of organic waste products considering that human animal and environment health are interconnected under the one health concept limiting their dissemination into the environment by implementing effective wastewastewater treatment technologies is a major option for limiting the emergence of these pathogens despite the research efforts focused on args the spread of vgs has barely been studied omitting a huge problem that cannot be separated from antimicrobial resistance this proposal will address both fundamental and applied aspects of the problematic fundamentally this proposal will provide a more comprehensive overview of the diversity of vgs and their cooccurrence with args in the wastewater treatment network and will study their cotransferability within complex microbial communities in addition this project will study for the first time the fate of vgs and their cooccurrence with args duringafter wastewastewater treatment also assessing the impact of different operational parameters on their mitigation particular attention will be paid to the impact that potential approaches allowing resource recovery eg nutrient and carbon recovery through manuresludge application as fertiliser on vgsargs dissemination with the emergence of superbugs being one of the main human health threats that we face the importance of this proposal is obvious
climate risk implications for finance and the real economy

classic climate risk implications for finance and the real economy intends to contribute to understanding how physical and transition climate risk impact the financial system and the real economy by quantifying the linkages and feedback between the twothere is consolidated evidence on the significant impacts of climate change on the real side of the economic systems however a much narrower even though expanding research has been done on the financial implications of climate risk identifying the source transmission channels direction and magnitude of these impacts is of primary importance to policymakers the business and finance community for a decisionmaking robust to climate risk effects on the global capital marketsclassic contributes to understanding how physical and transition climate risks impact the financial system and the real economy by quantifying the linkages and feedback between the two the project investigates the economic and financial impacts of physical climate risk and of transition risk posed by climate change mitigation policies in the context of the eu green deal and the eu fit for 55 policies methodologically an integrated modeling framework is built by coupling the macroeconomic representation of the real side of the economy with the financial side the multisector multicountry computable general equilibrium model ices intertemporal computable equilibrium system model describes the former while a climate financial risk module represents the latterthe applicant works with highly skilled leading partners who join forces to achieve the strategic objectives of classic the partners scientific excellence with their long teaming traditions provides a firstclass environment for training and research the ambitious plan for generation of impact and dissemination of outcomes paves the way to creating policies for effective targeting of climate risk and enables the creation of a new service for climate risk hedging
federated decentralized trusted data marketplace for embedded finance

fame is a joint effort of worldclass experts in data management data technologies the data economy and digital finance to develop deploy and launch to the global market a unique trustworthy energyefficient and secure federated data marketplace for embedded finance emfi the fame marketplace will alleviate the proclaimed limitations of centralized cloud marketplaces towards demonstrating the full potential of the data economy in this direction the project will enhance a state of the art data marketplace infrastructure ie h2020 i3market marketplace with novel functionalities in three complementary directions namely secure interoperable and regulatory compliant data exchange across multiple federated cloudbased data providers inline with emerging european initiatives like gaiaxdecentralized programmable data assets trading and pricing leveraging blockchain tokenization techniques including support for accruing data assets value in nftsintegration of trusted and energy efficient ee analytics based on novel technologies such as quantitative explainable ai situation aware explainability sax incremental ee analytics and edge analyticsfame will become operational in a federated cloud environment with multiple providers of emfi data assets including datasets aiml models and more it will become interconnected with more than 12 data marketplaces that are operated by the project partners as well as with other data infrastructures that will support the implementation of 7 pilots through this process the catalog of the fame marketplace will be populated with a critical mass of 1000 data assets furthermore fame will establish a learning center lc for tech and nontech users as this is a key prerequisite for unlocking the potential of the data economy fame will build a vibrant community of emfi stakeholders around the fame platform which will serve as a catalyst for the sustainability of the projects results
organoid technologies for disease modeling drug discovery and development for rare diseases

the vast majority of rare diseases are characterized by genetic origin often severe in pathology and with limited or no treatment options this also includes the paediatric disorders cystic fibrosis cf and cystinosis both diseases usually manifest in the first year of life in recent year great progress has been made in cf research allowing a swift transfer of novel drugs from bench to bedside this is fueled by the application of advanced in vitro models viz organoids in phenotyping patients and personalize treatment options in orgestra we propose to use stem cellderived organoids to train 13 doctoral candidates dcs in developing personalized disease models for the lung and kidney diseases cf and cystinosis with significant unmet clinical needs research will aim to identify pathogenetic mechanisms and druggable targets drug mode of action for effective and innovative treatment strategies classify the pathway to clinic and address ethical and regulatory issues to foster acceptance and implementation of the organoid models eventually a living technologies toolset will be developed for a swift transfer from bench to bedside orgestra will provide an international intersectoral and interdisciplinary training by creating a new expert framework of 14 partners from 7 countries combining molecular biologists engineers pharmacologists clinicians epidemiologists and ethicists giving each dc unique jointdoctoral training and tailored experience in industry andor patient organisations complemented with a rich workshop programme the orgestra objectives contribute perfectly to the horizon europe goals of the societal challenge on improving the health and wellbeing of the eu citizens
agroecological strategies for resilient farming in west africa

agriculture is one of the key focus areas of the partnership between the european union eu and the african union au with the eus focus being on facilitating a green transition according to its green deal gd objectives the gd is a set of longterm policy initiatives that define the eus climate strategy to reach net zero emissions by 2050 and its implications for africa are multifaceted such as the implementation of new agricultural standards deployment of the euafrica biodiversity strategy or creating a circular economyclimate change is projected to compromise agricultural production especially in smallholder systems with little adaptive capacity as currently prevalent in many parts of africa in particular west africa wa is known to be particularly vulnerable to climate change due to high climate variability or high reliance on rainfed agriculture and especially due to urgent drive to meeting food healthy diet and economic needsto support a transition to sustainable food systems agroecological farming is emerging as a compelling response to the challenges west africa faces aiming to reduce the environmental impacts of agriculture while meeting the growing demand for food contributing to landscape quality and biodiversity and enhancing resilience cirawa will unlock the potential of the agroecology in west africa by building on existing indigenous and scientific knowledge to improve food and nutrition security livelihoods and planetary health while tackling the climate change and environmental impact of agricultural practices cirawa will work on innovative agroecological approaches by the following strategies i valorisation of agrowastes and biobased fertiliser production ii production of high quality seeds iii saline soil reclamation through phytoremediation iv soil fertility water and crop management practices these will be deployed in 4 countries in west africa cape verde ghana senegal and the gambia
development of a synthetic diversification platform for targeted evolution of enzymes supporting a sustainable bioeconomy evozyme

the ongoing climate change requires immediate actions to reduce the co2 concentration in the atmosphere one such action is the transition from a fossilbased to a biobased economy that builds on co2derived onecarbon c1 feedstocks like formate to this end synthetic c1 assimilation routes are being engineered into biotechnological relevant microbes among them the reductive glycine pathway rglyp bears enormous potential for biotechnological applications as it is short energy efficient and easy to engineer so far optimization of growth on formate via the rglyp was achieved by adaptive laboratory evolution a timeconsuming process that leads to incorporation of undesired mutations and does not allow targeted pathway optimization debottleneckingin evozyme i aim to develop a synthetic biology platform for targeted evolution of pathway enzymes this platform consists of specialized escherichia coli strains that are equipped with stateoftheart diversification machineries allowing tunable hyperdiversificationevolution of target enzymes furthermore the platform is capable of transferring the diversified enzyme libraries to various bacterial hosts to benchmark the platform i aim to debottleneck the rglyp by targeting its core enzyme the glycine cleavage system gcs which catalyzes the ratelimiting step of glycine synthesis diversification and optimization of the gcs will be tested in dedicated selection strains from different bacterial hosts that can only grow if a functional gcs is expressed ultimately optimized gcs variants will be expressed in a formatotrophic e coli strain lacking a gcs improved formatotrophic growth will be analyzed in labscale bioreactors to determine technoeconomic parameters required for the establishment of a formate bioeconomy the platform developed in this project will enable debottlenecking of ratelimiting enzymes in virtually any pathway and presents a valuable tool for synthetic biology
glycan mimetics for cell glycocalyx reconstitution a polymer chemists approach to fight infection

objective the aim of glymce is to understand how carbohydrates and their assemblies are recognized by pathogens to drive infections the identified molecular patterns will be transferred to biomimetic glycopolymer materials to extend the arsenal for the fight against infectionscarbohydrates are not just sweet they are crucial in various biological interactions cell surfaces are covered in carbohydrates the glycocalyx that governs contact with pathogens such as viruses and bacteria a class of carbohydrates critical for pathogen attachment and infections are glycosaminoglycans gags gags are highly diverse polysaccharides already used in medicine eg heparin against thrombosis the potential of gags in fighting viral and bacterial infections has been recognized in biology and medicine but as of today there are no gagbased drugs used for this purpose a key limitation is insufficient knowledge about the mode of action of gags within the complex ensemble of the glycocalyxhow does the display of gags within the glycocalyx affect their pathogen interactionsglymce wglymce will tackle this question from the polymer chemists pointofview taking a bottomup approach to prepare gag mimetics level 1 assemble glycocalyx mimetics and study their spatial organization of gags upon pathogen binding level 2 reengineer the glycocalyx of living cells to understand the factors governing infection level 3 this is only now possible through recent synthetic tools developed by my lab enabling gag mimetics with controlled sequence molecular weight chain conformation architecture and sulfation patterns all parameters known to critically impact the affinity and selectivity of gags overall by taking a radically different approach informed by chemical biology and brought to life by polymer chemistry mechanisms for gagmediated pathogen attachment will be derived and applied to develop new materials and strategies to detect prevent and treat infections
renewing administration through democratic anchorage reforms

the radar project renewing administration through democratic anchorage reforms aims to enhance the democratic governance of public services and public administrations to construct legitimacy for public administration it will focus on democratic anchorage new narratives and educationradars first objective is to improve the understanding of the relationship between public administration reforms and democratic legitimacy this will be achieved through a scoping review multilevel statistical analysis of data from the european quality of government index a systematic analysis of emerging innovative solutions using a newly created database of innovation cases and a comprehensive analysis of reform discoursesradars second objective is to examine under which conditions efforts to improve the democratic legitimacy of public administration reforms are effective using a combination of research methods including experiments focus groups and case studies it will examine three types of initiatives that have shown the most promise participationcocreation representative bureaucracy and experimental governancethe third objective is to translate the findings from radars research into concrete methods to increase the input and output legitimacy of public administration allowing reforms and innovations to achieve results while respecting and strengthening democratic institutions radars final objective is to make methods to democratically anchor reforms and innovations part of the education and training received by current and future civil servants and policymakers with seven leading research institutes two national schools of government a ministry at the core of public innovation and an international ngo the radar consortium represents a wealth of research and teaching experience the partners are european leaders and innovators in their area of expertise and have the ability to cover all 27 eu countries as well as the western balkans
compact binaries as strong gravitational wave sources and progenitors of type ia supernovae

the accelerated expansion of the universe was one of the most striking discoveries in the 20th century and was only possible by using type ia supernovae sn iae only the thermonuclear explosion of a white dwarf wd following the interaction in a binary system can explain the observed features several different binary scenarios are discussed including the merger and subsequent explosion of an ultracompact double white dwarf double degenerate or an explosion triggered by helium accretion from a helium star donor double detonation the laser interferometer space antenna lisa is a spacebased gravitational wave gw detector which is currently being built by esa lisa will be sensitive to measure gws directly of thousands of galactic binaries allowing for multimessenger studies the pi proposes to conduct a detailed observational study to identify and classify at least a few hundred sn ia progenitors and lisa gw sources to 1 derive compact binary space densities and predict rates for different sn ia formation channels to solve the supernova ia progenitor problem 2 provide the first observationally derived population of resolvable lisa sources and galactic lisa foreground sources to achieve this ambitious project the pi will use ongoing and upcoming sky surveys such as ztf blackgem gaia vera rubin observatory and sdssv combined with largescale multiwavelength surveys the large number of sky surveys combined with recent developments in data processing including dense galactic plane regions makes this project very timely the results will calibrate theoretical models for sn ia common envelope evolution and will help to find the optimal data analysis methods for lisa so that its mission requirements can be achieved the pi will successfully lead this project because of his i profound experience in largescale skysurveys ii proprietary data access to blackgem data and iii direct involvement in multimessenger projects for lisa