Dragon09/odtu_chatbot huggingface dataset:
a pathway towards sustainable use and conservation of cephalopod stocks

our oceans provide food security nutrition poverty alleviation and livelihoods for millions of people worldwide however environmental and social pressures eg overfishing climate change population growth globalization threaten the oceans the marine resources and the people depending on them this is especially true for smallscale fisheries ssf which play a crucial often neglected role for local coastal communities in this sense alternative and effective ocean governance approaches are crucial for sustainable development and must adequately reflect the multidimensional and interconnected role of oceans in environmental health economic prosperity and human wellbeing succephs a pathway towards sustainable use and conservation of cephalopod stocks aims to i demonstrate how existing tools to assess fisheries sustainability succeed or fail to integrate multiple dimensions of sustainability and achieve improved ocean governance ii identify common and contextspecific factors that enable or hinder the achievement of sustainability in three octopus ssf iii improve the way octopus ssf sustainability is assessed and monitored embracing qualitative and quantitative data and applying a participatory approach succephs will tackle simultaneously environmental social and economic aspects of sustainability while considering the particularities of fishing communities and resources aiming to achieve improved governance to ensure equitable sustainable and resilient octopus fisheries now and for generations to come the project is designed to be a highly collaborative process requiring stakeholders partners and institutions to work together to cocreate novel and adaptive tools for achieving these goals a multicomparative approach will allow a deep learning and information exchange throughout the process
elucidating the role of rnabinding proteins in kaposis sarcomaassociated herpesvirus infected cells during latencyreactivation switches

kaposis sarcomaassociated herpesvirus kshv an oncogenic human herpesvirus is the cause of kaposis sarcoma ks primary effusion lymphoma and multicentric castlemans disease with no effective therapies like other herpesviruses kshv has a latent cycle with limited gene expression and a lytic cycle with expression of most viral genes and production of infectious viral particles rnabinding proteins rbp play key roles in rna biology including expression export stability processing and translation previous reports showed that rbps can function as proviral or antiviral viruses also express viral rbps there are no reports investigating the role of rbps during infection with dna viruses here we aim to determine the scope of host and viral rbps involved in kshv latent infection and reactivation to do so we will employ a multidisciplinary approach that combines cutting edge methods of molecular biology and virology with next generation technologies to discover cellular rbps that directly interact with viral rna and regulate kshv infection and tumorigenesis we expect also to discover novel viral rbps involved in kshv infection and pathogenesis the outcome of this project will be a comprehensive census of rbps with antiviral proviral and prooncogenic activities in the shortterm the knowledge obtained will facilitate the development of biotechnological applications to exploit the function of rbps in rna biology including rna visualization expression and translation in the longterm the proviral rbps could be targeted to develop hostbased antivirals therefore this project contributes to the eu global challenge of health and the eu mission cancer to ensure the successful outcome of this project i will contribute with my experience in molecular virology and my supervisors will train me in systemwide profiling of rbps and cuttingedge methods in virology ensuring the appropriate transfer of knowledge among the participants
nuclear singlet state in diamond for overcoming the standard quantum limit in gravitational wave detectors

the sensitivity of the nextgeneration gravitationalwave detectors gwd are critically limited by the quantum fluctuations of light the major sources of such noises are shot noise and optomechanical back action noise ban the improvement of sensitivity can be achieved by backaction evading bae measurements which allows overcoming the standard quantum limit by trading off between shot and ban recently a promising scheme has been proposed which involves another auxiliary system consisting of an atomic spin ensemble with negative effective mass that can suppress both the noises the measurement is performed by two entangled beams of light probing the gwd and the spin ensemble however the approach exhibits three major implementational issues to focus on which i have discovered by recent calculations firstly i study how the sensitivity of the gwd is dependent and what the constraints introduced by the entanglement measures between subsystems secondly i come with a novel approach for the bae by using a nuclear singlet state of carbon in diamond which works at very low nmr frequencies and bandwidth aiming to avoid the discrepancies of the match between the frequencies and linewidths of the spin and the mechanical oscillators in this aspect i propose using a novel type readout of electron spin of nv centers used as a nonperturbing ancilla of the nuclear spinsinglet finally based on the parameters obtained from ongoing etest project where a low thermal noise mechanical oscillator is being built up i will theoretically investigate if the nuclear singlet state can match the frequency and bandwidth of rational parameters of the oscillator and whether it can be implemented for the bae measurement i will study the role played by the input squeezing parameters and how to engineer the frequency range of noise suppression of the output the proposal entitles advanced handson training on experimental setups and profounding my background in gwd
superhydrophobic membranes for clean water production

our world faces an urgent need for a greener industry with reduced water consumption and zero pollution alleviating water scarcity problems membrane distillation md is being explored for production of clean water from industrial waste streams in the steel textile food and other industries several challenges need to be overcome to achieve a full commercial market breakthrough for md membrane wetting scaling and fouling we plan to accept the challenges by using superhydrophobic membranes such membranes are also useful in oilwater separation and a range of environmental applications during the fet harmonic project two rors max planckmpip and ncsrdemokritos developed complementary technologies for membrane superhydrophobicity which impart extreme antiwetting antiscaling and antifouling membranes the technologies are based on plasma activation or plasma nanotexturing ncsrd followed by wet nanofilament growth mpip or plasma deposition ncsrd for hydrophobization both institutions will advance their technology readiness level so the technology is validated demonstrated in relevant environment trl 56 and will design build and test small scale pilot equipment for fabricating rolls of superhydrophobic membranes in a rolltoroll format for the upscaling of the technology ncsrd and mpip will cooperate with two industrial partners namely europlasma and solsep respectively companies with large experience with rolltoroll plasma or wet processes respectively moreover they will team up with aquastill a manufacturer of commercial md modules for industrial wastewater treatment a market search and a business plan will be elaborated for creating a spinoff company commercializing the superhydrophobic membranes and processes the range of applications will go well beyond md
superscienceme research is your resource

research requires original ideas freedom rigor discipline and continuous study it requires knowing how to pursue goals accepting failures and frustrations and fully enjoying gratifications and satisfactions research gives unique opportunities and hope to the world especially to the new generations inspires people to get involved to believe in and gamble on themselves this is the message giorgio parisi fresh nobel prize in physics delivers to the world on the day of the awarding of the most important prize for a scientist and this is the message that superheroine superscienceme makes its own for the new edition of the european researchers night researchers are like curious children whose attention is inexorably attracted by the charm of nature they are inebriate by so much beauty then ask questions and seek for answers they study tirelessly attempting to unveil the secrets of the universe superscienceme aims at spreading this message to children young people men women and families in a historical moment in which people are bewildered facing challenges that seem insurmountable for mankind only science can help humanity to reach the summit and to scan the horizon of the future with hope for this noble purpose superscienceme asks for help from one of the greatest scientists that history can remember leonardo da vinci the italian genius will accompany superscienceme and modern scientists on a wonderful journey among the people to tell them the exciting fairy tale of sciencein line with the main scope of the mscacitizens action the project superscienceme research is your resource builds a symbolic bridge that connects past and future by passing through the present and gets researchers closer to the general public encouraging at the same time the youth especially the women to embark on scientific careers thus driving everyones effort towards a more equitable green resilient and healthy europe
characterization of the role of sac1 in the spatiotemporally controlled interplay between pi4p and cholesterol homeostasis

lipids are essential components of cell membranes every organelle membrane is constituted of a unique composition of different lipid species this distinctive lipid distribution along organelle membranes is important to maintain the identity and functions of the different organelles in this research project i aim to understand how the lipid species phosphatidylinositol4phosphate pi4p is regulated and how this affects lipid homeostasis and cellular functioning the pi4p distribution is important for intracellular signalling lipid and protein trafficking alterations in pi4p levels may contribute to the progression of other neurodegenerative disorders eg alzheimers disease in this project i will study the pi4p phosphatase sac1 sac1 consumes pi4p in the endoplasmic reticulum or golgi apparatus this locally lowers pi4p levels therefore maintaining the asymmetric distribution of pi4p in the cell the pi4p gradient is important for the transport of lipids and proteins in cell models sac1 knockdown or knockout severely compromises cell viability whereas sac1 knockout mouse or drosophila are embryonically lethal this highlights the importance of sac1 however making it difficult to examine the physiological functions of sac1 in this project i will use an auxininducible degradation aid system to induce the degradation of sac1 within one hour this allows me to assess the acute effects of sac1 depletion using this model i will address the following key objectives 1 examine the role of sac1 in lipid homeostasis 2 investigate the regulatory mechanism of sac1 in golgi morphology and kinetics and 3 characterize a inducible degradation system in zebrafish by employing the aid system in a zebrafish model i aim to provide a new means to study the role of sac1 in development taken together this project will contribute to deeper insights into the regulatory function of sac1 in lipid homeostasis and selective protein secretion
environmental effect on health care and wellbeing and active interventions

noncommunicable diseases ncds account for 80 of the disease burden as well as for the majority of premature deaths in the eu diminishing the citizens quality of life life expectancy and increasing the financial burden from those affected to the health system during the last 3 decade environmental stressors have been addressed through numerous studies which have raised concerns about the detrimental effects of the environment on human health most evaluated environmental stressors are air temperature particulate and gaseous air pollutants urban noise food pollutants and radiation by end of 2022 air pollution was reported to be responsible of an excess mortality of 311000 people per year in the ue27 driving not only premature deaths but also an increased risk of vascular diseases such as ischemic heart disease stroke and other noncommunicable nonvascular diseases like chronic respiratory diseases or depression some newly considered stressors such as electromagnetic field and light exposure are also susceptible to affect human health eg ocular and dermatological ncd diseases enact aims at building a pathway to generate clinical technological and economic short longterm impact targeting local and regional stakeholders and create impact by developing a stateoftheart environmental risk score and analyser driven framework and platform to predict monitor and prevent the exposomic risk of acute and chronic health conditions of chronic vascular and nonvascular ncds this new exposomic risk score and analyser will support a patients b health professionalshospitals and c policy makers aiming at reducing the human and financial burden of ncd considering potential individual vulnerability factors and reinforcing both a clinical and a policy implementation that enables prevention and disease management for higher quality of life
social sciences and humanities for climate energy and transport research excellence

the social sciences humanities for climate energy and transport research excellence ssh centre project brings together 13 leading organisations from across the eu including 3 universities 4 research institutions 2 stakeholder network organisations and 4 ri and communications smes our partners bring worldleading expertise across ssh and stem disciplines applied to climate energy and mobility covering neutrality communityled initiatives heating and cooling circular economy and sufficiency and digital technologies partners will reach 228880 stakeholders by leveraging their significant experience in transdisciplinarity and citizen engagement and networks that span academia policymakers at various levels the private sector civil society and citizens our objectives directly address the call challenge with an aim to support crosssectoral collaborations and empowerment of citizens and networks towards the development of socially innovative solutions for the eus climate transition issues related to open science inclusivity and diversity especially with regards southern and eastern europe and different career stages are at the heart of the project ssh centre will meet its objectives through a set of 7 carefullydesigned work packages key activities involve development of novel sshstem collaborations to facilitate the delivery of the eu green deal ssh knowledge brokerage to support regions in transition and the effective design of strategies for citizen engagement in eu ri activities outputs include actionled agendas and building stakeholder synergies through regular policy insight events the highprofile virtual ssh centre and its 660 members will thus represent a goto gateway for cluster 5 ssh research excellence delivering inclusive governance and engagement approaches the centre will generate and share best practice for ssh policy advice overcoming fragmentation to accelerate the eus journey to a sustainable future
targeting the undruggable leveraging neomorphic dnabinding preferences of chimeric fusion oncogenes to promote cancer suicide

many aggressive cancers such as pediatric highrisk ewing sarcoma and alveolar rhabdomyosarcoma are fueled by and addicted to chimeric oncogenic transcription factors otfs so far all attempts to suppress these potent otfs largely failed wherefore they are classified as undruggablethis proposal challenges this dogma with a novel strategy to leverage rather than to suppress the exquisite neomorphic dnabinding preferences of otfs to express therapeutic genes specifically in cancer cells in pursuing three ambitious aims this project goes far beyond an original proofofconcept study in which we drove pediatric cancer cells in preclinical models into suicide cancerharakiri via viral transfer of therapeutic genes induced by the specific interaction of an otf with its neomorphic dnabinding motifin aim 1 we will genetically engineer and functionally test a conceptionally advanced viral vector in vivo with optimized general design oncotropism and therapeutic payload focusing on immunooncological aspectsin aim 2 we will comprehensively map the regulome of otfs using novel reporter cell lines singlecell sequencing rnaiscreens and crispr interference to identify and validate otfinhibiting genes that can be cotargeted in our vector to prevent escape variants with low otfactivityin aim 3 we will integrate insights from aims 12 into our new vector design translate our therapeutic approach from our main model entity ewing sarcoma to other otfdriven cancers and set the stage for gmpcompliant virus production and initiation of a clinical trialthis integrative approach combines expertise and technology across disciplines with original experimental tools to afford a comprehensive understanding of the otfregulome and to rationally design and leap ahead an innovative therapeutic concept which has the potential to revolutionize the therapy of metastatic otfdriven cancers thus we will exploit the undruggable to promote cancerharakiri
assessing the impact of climate fluctuations on hibernation phenology using novel dental biomarkers

many heterothermic mammals exploit multiday torpor ie hibernation to face harsh climates the timings and the regulations of this process are controlled and influenced by several intrinsic and extrinsic factors such as eg the circannual biological clock of the animal the daylength the spring temperature the snowmelt date yet how these animals answered global climate changes is still a matter of debate with the arouse project i will examine the hibernation timing and the bone elemental metabolism of small mammals from a new unexplored perspective by analyzing welldated fossil and modern hibernating rodent teeth straddling the last glacialinterglacial cycle specifically i will exploit the enamel incisor microchemistry highspatially resolved elements and isotopes histomorphometry and proteomics of geographicallyconstrained alpine marmots to 1 precisely measure sexspecific hibernation length 2 investigate metabolic changes in relation to paleoclimate seasonal fluctuations 3 unravel dental enamel secretion and mineralization behavior during winter torpor 4 search for specific dental chemical biomarkers of hibernation transferable to other disciplines for the first time this project will provide a robust tool for the retrospective study of hibernation events in dental specimens allowing to deepen our knowledge about hibernation plasticity but also to possibly investigate the evolutionary trajectories of torpor in deeptime arouse will also help to understand how marmots adapted to secular climate variations possibly forecasting the effects of global warming on modern hibernating mammals
leveraging polymer therapeutics as nanomedicine for local glioblastoma immunotherapy

research focusing on cancer immunotherapy has provided little progress toward improved survival rates for patients with glioblastoma gbm a poorly immunogenic tumor clinical trials for gbm immunotherapy primarily focus on the systemic administration of therapeutics however they have shown limited therapeutic success the bloodbrain barrier the tumor immune microenvironment time the extracellular matrix the highly invasiveproliferative nature of gbm and intra and interpatient heterogeneity represent challenges to immunotherapy success administering polymer therapeutics as a class of biodegradable nanomedicines for localized treatment a concept i pioneered represents a less explored area that may fulfill the potential of gbm immunotherapy while reducing doses and adverse systemic effectsgliomers aims to design an immunomodulatory brainpenetrating polymeric drug delivery system that will exploit its intrinsic therapeutic effect by synergizing with conjugated chemotherapeutic agents to directly stimulate antitumor immunity by encompassing different biomaterials properties hybrid nanocarriers will be developed using a synthetic microfluidicassisted approach based on chemically stabilized selfassembled hyaluronic acid as immunomodulator with complementary polyllysine to support brain penetration i will capitalize on the properties of this new class of nanocarriers by conjugating chemotherapeutics repurposed for immunotherapy this approach will allow not only the local spread of the drug within the gbm but also an additional rewiring of immunosuppressive time with an enhanced t cellmediated immune responsegliomers will provide an innovative advance in the design of translational nanomedicines for local brain delivery contributing to enhanced immunotherapeutic efficacy for gbm treatment
europes ethnoschism nordic manliness vs latin glamour 19141929

ethnoschism traces an ambient diffuse but influential ethnotype that of a manly roughhewn north vs a frivolous charming south the former framed in terms of its germanic ethnolinguistic roots the latter as romance or latin it analyses the widelyramifying discursive diffusion of this ethnotype in its continuing banal presence as a frame for social and political relations the subject is highly topical raising the stillburning issue of national intraeuropean divisions in terms of imputed national characters by going it back to the years of their crystallisation 19141929 and studying the impact of cultural representations have in the political prejudices and ideologies ethnoschism develops a new interdisciplinary theory of the european northsouthopposition by studying its conceptual history from a radically interdisciplinary basis combining the latest insights in 3 related specialisms in the culturehistorical humanities imagology the history of knowledge production namely in racial theorizing the intellectual history of european nationalisms it studies ethnotypes in a completely new and original way using them as a common discursive factor in the cultural field of representations and the political history of international relations the methodological toolbox includes methods and approaches from different disciplines the transnational and interdisciplinary history of national thought discourse historical approach imagology the outputs include two articles a commented anthology an edited book two academic workshops measures to communicate the project activities include a website on the project a temporary exhibition the creation of an educational package for secondaryschool students research and training activities at the dept of european studies uva will directly benefit my career prospects equipping me with new skills and knowledge and placing me at the forefront of the field as an interdisciplinary researcher