Dragon09/odtu_chatbot huggingface dataset:
innovating thyroid health with genomics and predictive algorithms through collaborative excellence

global research indicates that millions of people suffer from thyroid disorders such as hypothyroidism hyperthyroidism autoimmune diseases and tumors with nearly 60 of them unaware of their condition autoimmune thyroid diseases notably hashimotos thyroiditis and graves disease are the most prevalent affecting about 5 of the population thyroid cancers are also on the rise with significant increases in detection over recent decades despite various treatment and diagnostic options many face misdiagnosis ineffective treatments and diminished quality of life levothyroxine a synthetic thyroid hormone is widely prescribed in europe and the usa yet 2050 of patients experience improper dosing necessitating frequent adjustments antithyroid medications can cause severe side effects underscoring the need for careful management of thyroid diseases to avoid increased healthcare costs and lost productivity current treatment approaches often not personalized overlook genetic predispositions and environmental factors advances in genomics such as nextgeneration sequencing ngs and the polygenic risk score prs offer new opportunities for personalized medicine these tools combined with electronic health records ehr and lifestyle data can improve disease prediction and prevention strategies pharmacogenomics further enables tailored drug treatment based on individual genetic profiles promising more effective and personalized care the design of thyroid disease gene panels and the development of innovative and digital solutions based on artificial intelligence stand as pivotal advancements these could markedly accelerate the integration of more personalized and costeffective approaches into clinical practice heralding a new era of precision medicine for thyroid disorders
how does autophagy rescue stalled ribosomes

multiple ribosomes simultaneously move along the mrnas to translate the genes into proteins cellular stress triggers collisions of ribosomes and disrupts protein synthesis eukaryotes have evolved multitiered quality control mechanisms that monitor ribosomes and rescue them on collision while much is known about the rescue of cytosolic ribosomes how the cell rescues stalled endoplasmic reticulum bound erbound ribosomes remains unknown we recently discovered that the stalling of erbound ribosomes induces autophagy a major cellular degradation pathway we discovered two autophagy receptors that are induced upon stalling of erbound ribosomes and these proteins are conserved between plants and humans we also showed that ufmylation an elusive posttranslational modification system regulates erbound ribosome stallinginduced autophagy these two discoveries indicate that autophagy plays a major role in the maintenance of a functional erbound ribosome population based on these discoveries i hypothesize that autophagy rescues stalled erbound ribosomes by selectively degrading harmful polypeptides and rnas that clog the ribosomes during collisions here i propose to define and characterize this conserved quality control mechanism i will establish a suite of complementary methods in the model plants arabidopsis thaliana and marchantia polymorpha to explore the physiological significance of autophagymediated ribosomal rescue riborescuephagy in complex multicellular organisms in parallel i will carry out unbiased genetic screens in human cell lines to discover the molecular components that mediate riborescuephagy finally i will perform structurefunction analysis of a key ufmylation enzyme to untangle the connection between ufmylation and autophagy at the completion of this project we will have defined a new quality control mechanism that rescues stalled erbound ribosomes to maintain cellular homeostasis in eukaryotes
exploring the potential of oleaginous microalgae monoraphidium neglectum for wax ester production

wax esters wes are neutral lipids of major industrial importance used as components of lubricants pharmaceuticals and cosmetics largescale production of wes is based on chemical processes which utilize mainly petroleumderived feedstocks and generate hazardous waste with diminishing fossil reserves demand on industrial raw materials and predicted effects of global warming there is a strong need for alternative biobased production of wes from renewable resourcessince we synthesis requires only two enzymes fatty acyl reductase far and wax synthase ws metabolic engineering approaches enabled we production in genetically modified plants bacteria and yeast interestingly to date there are no reports on establishing we synthesis in oleaginous microalgae which due to fast growth rate and high oil content are strong candidates for the weproducing platforms among them a green alga monoraphidium neglectum is a particularly promising species due to its favourable fatty acid profilethe main goal of the project is to establish we production in m neglectum using genetic engineering and its further enhancement via optimisation of culture conditions orand further modification of lipid metabolism in the first stage of the project i will develop a vector toolkit for efficient gene expression in m neglectum then i will use the toolkit to introduce different combinations of fars and wss to microalgae cells i will also investigate whether we accumulation in m neglectum can be modulated by stress conditions finally the cultures of weproducing transgenic microalgae be scaled up to verify their productivity and we yield in parallel i will test several strategies to boost we production by modification of carbon flux in a model green alga chlamydomonas reinhardtii and use the most successful ones to further modify m neglectum the outcome of this project will be a valuable contribution to the future development of new strategies to produce wes
the ungovernable city interest groups and local political institutions in the united states and europe

as nations in the developed world strive to reduce carbon dioxide emissions to counteract the effects of climate change transitioning from more carbon intensive cities to greener modes of housing and transportation will become paramount challenges for governments throughout the 21st century the united states who produces about 11 percent of co2 while accounting for just two percent of the worlds population presents a particular challenge infrastructure costs in the united states are astronomically higher than in comparable developed nations in europe or asia further housing constructionespecially dense urban housing and its accompanying low carbon profileis nearly impossible to build in almost all major american metro areas due to restrictive land use policies an abundance of veto points exploited by engage local interest groups and americas strong federalist institutions that give deference to local governments when deciding land use policy this project seeks to understand how interest groups in the united states capture local housing and land use policymaking and why a similar phenomenon hasnt evolved in many european union nations studying local interest groups in a comparative setting will better illuminate how weaknesses in political institutions engender this behavior and lead to differing outcomes between the two regions identifying these institutional deficiencies will also aid reforms in the united states crucial for modernizing that democracy and aiding the global fight against climate change this project will also deepen understanding of how interest groups form and evolve what motivates the transition from individual financial motivation to the formation of an interest group and how these groups capture local political institutions
techcoach connecting operational groups across borders to enhance farmers ability to assess adopt and integrate smart crop farming technologies

smart crop farming technologies allow farmers to optimize inputs and tailor cultivation practices to specific crop requirements despite the potential of these technologies to enhance agriculture their adoption remains surprisingly low in europe wellorganized farmerfocused multiactor advisory systems and networks can play a crucial role for farmers to understand and implement smart crop farming technologies these advisory systems involve multiple stakeholders and prioritize farmers needs while enabling knowledge exchange among diverse players operational groups ogs provide a strong platform for this but many lack the required capabilities techcoachs main objective is to strengthen farmers ability to assess adopt and integrate smart crop farming technologies at the farm level by facilitating collaborative innovation and multiactor advisory in operational groups and akis this will be achieved through the mobilization of ogs and akis actors as well as the utilization of existing and new thematic networks and multiactor approach projects to gather and disseminate knowledge and experience for application in local contexts across europetechcoach will serve a dual purpose 1 strengthening the results of operational groups and 2 accelerating these results through networks at the national and eu level the approach includes 3 levels of interventions firstly we learn how eip operational groups facilitate their members in the adoption of smart farming technologies good practices are described and gaps are identified at the start of the project techcoach will work with 10 ogs in 5 countries secondly we connect project ogs other ogs and akis actors in national networks to share knowledge and experience on the theme of facilitating smart crop farming adoption and to narrow the identified gaps and thirdly we connect ogs and national networks across borders and enhance paneuropean learning and collaboration in smart crop farming
vibrational speckle tomography microscopy for fast intraoperative cancer tissue histopathology

histology is central to the diagnosis staging and treatment of cancers it requires the removal of small regions of suspect tissues biopsies that are later sectioned and stained with haematoxylin and eosin he however histology suffers from major weaknesses first the standard he protocol cannot work in vivo and requires ex vivo biopsies second he is labour intensive time consuming and the final tissue sections inspection is possible only after 12 hours a faster but less accurate protocol known as extemporaneous histology can be performed in 40 min and is used in an intraoperative context to guide surgeries the specklecars project aims to develop for the first time fast label free tomography microscopy with vibrational sensitivity to provide images with tridimensional improvement as compared to extemporaneous histology and in nearperfect concordance with conventional stained he histology this pioneering approach overcomes all the previous challenges using a wide field reflection scheme and label free contrast rules out all the drawbacks due to tissue removal and external labelling it provides instantaneous intraoperative 3d histological data improving the accessibility and accuracy of tumour detection diagnosis and treatment combining the latest advances in 3d tomography reconstruction algorithms high power laser systems together with key innovations in random speckle illumination and hyperspectral vibrational imaging the specklecars project will provide for the first time volumetric histology imaging in real time over large mm fields of view without the need of tissue removal to demonstrate the power of the developed technologies both ex vivo human and in vivo mouse cancer assessments will be conducted in collaboration with pathologists the specklecars approach is broadly applicable to all cancer types and to any tissue diagnostic requiring histological data so the project breakthroughs will benefit many medical and biology applications
carbon imides bearing distortedringembedded helicene for chiral electronics

one of the major goals of the european union is to accelerate the twin green and digital transitions to achieve climate neutrality in europe one of the specific measurements that have been proposed is the development of novel organic materials to apply them in organic semiconductors oscs the reasons behind this lie in their cost and their improved processability compared with the traditional inorganic materials in addition the synthesis of new oscs is one of the key aspects of the scientific development of nextgeneration optoelectronic devicesiberian project aims to contribute with the synthesis of new organic structures perylene diimidebased with attractive chiroptical properties to apply them in organic electronics the great novelty of the project is perylene diimide pdi derivatives will produce large chiral absorption and emission light even in the near infrared region thanks to the insertion of an extremely distorted skeleton by the combination of helicenes with nonhexagonal rings such highly contorted and twisted structures incorporating rings of unusual size will be unique in the pdi chemistry landscape and push the limit of the structureproperties relationship understanding of chiral ntype oscs besides a through characterization especially in solidstate will be achieved to decide in which kind of device these new material can be implementedthe development of organic electronics would have a huge impact at all levels creating many job opportunities contributing to reach the climate neutrality and rising the technologies of the future the iberian results will be broadly communicated as open as possible through open peer reviewed article resources and public outreach activities
structuring quantum light for microscopy

optical microscopy perhaps the most important tool in biomedical investigation and medical diagnosis provides structural and functional information about biological specimen in a noninvasive and nonionizing way however this technique still faces the challenge of imaging small and weakly scattering objects ega single cell embedded inside complex biological tissues causing optical aberrations and scattering this problem is even more critical in the case of samples that cannot be labelled or do not spontaneously emit light in sqimic i will go one major conceptual step beyond the current paradigm by merging the fields of quantum imaging and light structuring to build a new quantum toolbox for microscopy my novel approach is based on my pioneering work showing that wavefront shaping techniques initially developed for laser light manipulation can also shape higher orders of optical coherence allowing deterministic tailoring of quantum properties of light such as entanglement i will use this approach to leverage some genuine quantum imaging concepts such as quantum holography quantum interferences and quantum illumination to break the current limits of fluorescentfree classical microscopy and image complex objects with higher resolution better contrast reduced aberrations and less noise ultimately i aim to deliver a quantumenhanced microscope with unprecedented performances that can be used as a practical tool for biological imaging without labelling the specimens or relying on their possible ability to emit lightfrom a methodological standpoint sqimic will bridge knowledge from quantum imaging light structuring adaptive optics wavefront shaping sensors technologies and computational imaging it will deliver a whole new class of optical imaging methods based on quantum light manipulation and detection its longterm core applications are in lifescience and biomedical imaging with potential extension to quantum information science
realtime optimisation solutions for embedded nonlinear model predictive control applications using the lpv framework

most modern technological applications of social relevance such as renewable smartgrids and autonomous cars consist of systems with complex dynamics operating under fast sampling these processes exhibit behaviours that can only be accurately represented by means of nonlinear models thus complex with sampling periods of micro to milliseconds which means that decisionmaking should be done under such time these systems only operate satisfactorily when adequate control methodologies are used taking into account performance goals operational constraints and physical metrics thus this project focuses on the development of realtime optimisation for control using the model predictive control mpc frameworkmpc is a very established approach centred on generating decision actions by solving an optimisation problem over the last decades considerable scientific effort has been devoted to the study of mpc expounding its vast pertinence yet applying mpc with nonlinear models issues increased digital complexity typically incompatible with realtime environments the standard practice consists in applying approximated solvers which are not reproducible nor optimalrecent works have shown an alternative to render realtime capable algorithms designing nonlinear mpc using the linear parameter varying lpv toolkit even though the theoretical side of lpv mpc is presumably established and several results indicate competitiveness against stateoftheart solvers the translation to a practicallyviable tool is not yet rendered universal that is a readyforapplication mpc solver using lpv representations is not yet available accordingly the main goal of this project is to develop a comprehensive realtime optimisation solver based on lpv mpc such a tool would ensure optimality representation exactness and generate control laws within the microsecond range contributing as a technological advance oriented to modern application of social concern
14 anstrom cmos ic technology

14acmos is about enabling manufacture of 14a semiconductor technology it addresses the 4 key pillars in ic technology development for manufacture lithography metrology mask infrastructure and process technology carl zeiss trumpf and asml are the main parties to push the lithography solutions to 14a between carl zeiss fraunhofer rwth uw and tno further understanding of optics life time and plasma physics is pursued in optimizing optics transmission and lifetimenova brt ilt and ptb address measurement sensitivity enhancement of xray and optical based methodologies to meet the 14a requirements imec tno ptb upb and rwth will combine and tune metrology techniques specifically for the assessment of euv reticle degradation on throughput and resolution enhancement bruker exc ptb and amil will work on xray sources and amil ict and nfi on ebeam and spm platforms for inline metrology on the reduction of total measurement uncertainty prodrive and amil cover the development of an ultrahigh precision wafer stage and nvidia amil and prodrive the development of a next generation image processing system in mask infrastructure there are fhg iisb asml carl zeiss covering the creation of a simulation based mask repair strategy and with carl zeiss asml pi and upb hwsw and process technology for particle removal is created and repair durability is covered with carl zeiss asml suss and upb process technology covers the creation of patterning solutions with the involvement of imec and tel on active device selection there will be imec cadence ibs jsr recif and tel with thermo enabling advanced tem characterization middle of line and back end of line solution development is with imec tel solmates and coventor for process modules and cadence the interface with the design community on sustainable semiconductor technology and systems there are imec recif and thermofisher covering sustainable material and processing alternatives
strategic reasoning for socially good mechanisms

the design and evaluation of mechanisms for aggregating preferences is a central problem in multiagent systems mas in such setting we need to be able to aggregate individual preferences which are conflicting when agents are selfinterested more importantly the mechanism should choose a socially desirable or good outcome and reach an equilibrium despite the fact that agents can lie about their preferences the realworld applications of designing and verifying mechanisms for social choice are manifold including fair division protocols secure voting and truthtracking via approval voting although logicbased languages have been widely used for verification and synthesis of mas the use of formal methods for reasoning about auctions under strategic behavior as well as automated mechanism design has not been much explored yet an advantage in adopting such perspective lies in the high expressivity and generality of logics for strategic reasoning moreover by relying on precise semantics formal methods provide tools for rigorously analyzing the correctness of systems which is important to improve trust in mechanisms generated by machines this project aims to design a logical framework based on strategy logic sl for formally verifying and designing mechanisms for social choice more specifically we aim at i proposing an approach addressing the probabilistic setting with bayesian information stochastic transitions and mixed strategies
strenghtening phytosanitary research programming and collaboration from european to global phytosanitary research coordination

it is not possible to avoid all the challenges to plant health posed by global trade increasing travel activities and climate change however it is possible to optimise strategies to address these challenges with effective cooperation and coordinationthe success of the euphresco selfsustained network as a platform for the coordination of european phytosanitary research has set the ground for discussions on the development of initiatives to address the needs of other regions of the world and on global phytosanitary research coordination the aim of the project is to enhance national and regional phytosanitary research coordination beyond what the euphresco selfsustained network has achieved and to set the foundations for global phytosanitary research coordination this will be achieved by building on the foundations developed by the euphresco selfsustained network and explore fitforpurpose activities the objectives of the project areto develop a strategic research agenda the document will guide phytosanitary research programming activities of eu countries and support them to address regional and global challenges through synergies with other regionscontinents of the world to organize joint calls on common research priorities to support and enhance international collaboration through the commissioning and implementation of research projects monitoring of the research projects will ensure that they remain relevant to the needs of the research funders and policy makers and impactfulto develop and test models for the governance the structure and the operation of a global network for phytosanitary research coordination a business plan will be established to guide the development of a global network for phytosanitary research coordinationto engage with relevant plant health research stakeholders and foster knowledge exchange engagement in the project activities codevelopment dissemination and adoption of outputs