Dragon09/odtu_chatbot huggingface dataset:
unlocking the power of medical images for surgeons

surgeons depend on medical images to make difficult decisions mris and ctscans that are difficult to interpret can lead to unnecessary surgeries more invasive operations and slower recoveriesthe avatar surgery solution is a groundbreaking productivity tool for surgeons and medical specialists it is the first photorealistic xr viewer of 3d medical images based on innovative machine learning algorithms and data visualization techniques with the express objective of enhancing medical decision makingthrough highfidelity local or cloudbased render streaming avatar will be the first solution to meet surgeon expectations for seamless preoperative and intraoperative data integration our clinical applications will assist surgeons in planning and implementing specific proceduresfor hospitals struggling to manage growing demand for surgery avatar promises to provide valuable productivity gains without investing in new equipment or personnel
minimally invasive neuromodulation implant and implantation procedure based on groundbreaking graphene technology for treating brain disorders

neurostimulation therapies hold the promise to treat brain diseases refractory to pharmacological treatment however these therapies are not fully adopted due to important technological and clinical challenges such as highly invasive implantation multiple side effects due to offtarget stimulation low signal resolution and lack of personalized therapies the minigraph project aims to develop a groundbreaking neuromodulation therapy that addresses current needs of the field we will develop and validate a new generation of brain implants with closedloop neuromodulation capabilities enabled by skull implanted flexible electronics unit and miniature and highdensity arrays of graphene microelectrodes our implant will feature high miniaturization large spatial resolution and optimal biocompatibility with brain tissue the closedloop capabilities will enable to develop personalized and adaptive therapies depending on patients needs in addition we will also develop and validate a minimally invasive implantation procedure with high precision implantation and low invasiveness through a single small skull incision the minigraph project outcomes will truly revolutionize the way we treat neurological and neuropsychiatric diseases in the near future to achieve our ambitious objectives we have put together an interdisciplinary consortium formed by highrenowned research centers and a highpromising sme with all the expertise and resources needed to complete the project within time and budget our project addresses the objectives of the tools to measure and stimulate activity in brain tissue pathfinder challenge as it provides 1 miniature and minimally invasive brain implants 2 closedloop neuromodulation therapy for personalized medicine 3 biocompatible ultrathin and flexible neuroelectrodes and 4 minimized power consumption solution all together we believe the minigraph project will be a unique addition to the challenge portfolio
agriculture waste pyrolysis and thermocomposting for renewable energy in sustainable agrifood sector

teapots aims to give agrifood players an innovative integrated modular and flexible solution to meet local and seasonal energy demand through the valorisation of lignocellulosic and difficult to be treated agricultural waste while producing biochar the first valorisation process will employ pyrolysis to extract heat from waste heat will be employed by an organic rankine cycle to produce electric energy which will be employed by a dry cooler oilfree awc to cool down cold rooms for storing agrifood products the second process will extract heat using a compost heat recovery system to harness hot water from the oxidation of biomass while producing compost heat will be used to provide sanitary hot water these technologies will be integrated in the teapots integrated solution tis to demonstrate the feasibility of the entire process using all the modules to provide refrigeration biochar and compost will be used as plant biostimulants to increase yields and store carbon in soil improving the environmental footprint of the enduser feedstocks to be used in the tis will be mixed to improve energy production and products quality field and satellite data will be gathered to evaluate biomass growth while the tis operational data will be used to evaluate the environmental impact through lca analysis and the overall functionality of the solution data will be integrated in a database which will allow the prediction of waste biomass production this will be used by a data driven decision support system dss to improve field and waste logistics which will provide the means to keep the tis up and running the prediction system and the dss will be integrated in the teapots digital platform which will have an easytouse user interface to help endusers in the management of the entire solution a multyactor approach will be employed to create a network of biomass producers interested in using agricultural waste to improve their environmental impact
smart integration of waste and renewable energy for sustainable heat upgrade in the industry

susheat develops and validates up to trl 5 3 novel enabling technologies hightemperature heat pump hthp phase change material pcm bioinspired thermal energy storage tes system and control integration twin cit system for heat upgrade in toplevel labs it will attain an efficient heat upgrade up to 150250 c thanks to the use the innovative stirlingbased hthp working with hellium and enlarging the industrial exploitability of heat upgrade systems reaching a cop up to 28 for temperature ratios of 12 the integration of innovative tes will ensure a reliable flexible and customizable heat delivery with full decoupling from any waste heat recovery and renewables availability moreover its cit will provide userfriendly tools and a digital twin for the control system and advising industrial stakeholders based on smart decisionmaking algorithmssusheat will bring an effective selfassessment of the most suited heat upgrade system integration including not only its key enabling components but beyond also leveraging on offtheself resbased units particularly solar thermal collectors even enlarging the feasibility of concentrating solar power systems that can extend its operation working at low temperaturetwo casestudies are replicated for validation at trl5 and 4 additional cases are analysed indepth to cover other sectors as pulp paper beverages petrochemical textile leather and basic metalsby developing industryfocused selfassessment tools and directly engaging different industrial stakeholders susheat will contribute to identify the target industrial processes and sites which would benefit from the concept rising awareness of various heat upgrade benefits within the industry and providing solutions to maximize the industrial efficiency while contributing to the sectors decarbonization reducing the ghg emissions up to 145 gco2kwh excluding solar contribution and based on eu 2020 intensity and the use ng
multimodal labelling probes for correlative nanoscale mass spectroscopy imaging optical and electron microscopies

the applications of the integrative imaging approach relying on a unique combination of correlative microscopy methods such as secondary ion mass spectroscopy sims and optical microscopies such as stimulated emission depletion sted and electron microscopy em are powered by the development of novel labelling probes for imaging which play a pivotal role in their progress there is currently a lack of new probes that can provide a high signaltonoise ratio and low background in correlative microscopy during the acquisition process by photon counter and mass detector therefore many scientists still cannot apply these advanced microscopy methods to their samples the unique probe features will result in better contrast and spatiotemporal resolution of the obtained images now organic chemists can use the developed organometallic reactions to obtain the target fluorophores for probe construction this research initiative relying on the tailormade design and elaborated synthetic strategies will allow obtaining a new class of unique imaging probes with optimized optical properties the new labelling probes together with the optimized protocols for sample preparation and image analysis will help get better image quality which altogether will provide multidimensional information about the studied samples i will develop new labelling tools for correlative multimodal imaging structureproperty optimization of such labelling tools requires a tailormade design of the fluorescent dye which will not compromise intrinsic photophysical properties responsible for its fluorescence such as photon or quantum yield i will employ three different biochemical approaches to obtain the labelling probes the probe design comprising functionalized nanobodies gold nanoparticles and fluorophores will be unique i foresee a broad application of the obtained probes for multimodal bioimaging when they become available to a community of cell biologists and microscopists
gabaergic interneurons signaling imbalance a promising target underlying pfcdependent cognitive flexibility defects

covid19 pandemic has highlighted the importance of making decisions and adjusting our behavioural strategy to tackle unexpected changes in our environment the cognitive flexibility required to modify behaviour when the rules change is ascribed primarily to the prefrontal cortex pfc but the exact mechanisms underlying this phenomenon remain unknown inhibitory gabaergic interneurons ins seem to play a key role in this process by modulating the primary excitatory pyramidal neurons activity in the pfc indeed individuals who have deficits in these ins a common feature in many mental disorders often fail to adjust their behaviour to a rule change even though their ability to learn an initial rule remains intact the two main in subsets parvalbuminpositive pv and somatostatinpositive sst have different anatomical and physiological characteristics suggesting distinct functions we thus hypothesize distinct roles for each subtype pv cells may control the gain in pyramidal neuron activity thereby affecting behaviour sst cells however may control the ability to learn a new rule via plasticity in dendrites thereby affecting behaviour but leaving pyramidal neurons activity intact combining genetic imaging and behavioural techniques in freely moving mice with in silico studies we will dissect the effects of of longterm dysregulation of pv and sst ins on the pfc circuit function with respect to flexible behaviour our experimental results will be fed to a computational model of the pfc circuit to further investigate how interneuronal control of information affects cognitive flexibility and to explore mechanisms that can reverse cognitive flexibility defects unravelling the mechanistic role of cognitive flexibility in the pfc will not only further our understanding of a complex brain function it will also open new avenues for developing therapeutic approaches for numerous mental disorders thus ameliorating a large societal and economic burden
electrochemical synthesis of hydrogen peroxide from water air and renewable electric energy

in line with the european green deal the processes4planet partnership and the european initiative for more affordable secure and sustainable energy repowereu the ria proposal power2hype aims to establish a sustainable route for the hydrogen peroxide production based on air and water as feedstocks and renewable energy as the sole energy source the power2hype route addresses an economically viable and green alternative to the classical energydemanding anthraquinone oxidation ao process hydrogen peroxide will be produced by paired electrolysis at both the cathode and anode using an innovative custommade 200 electrolyser aiming the electrification and decentralization of the chemical industry the power2hype concept proposes the trl 6 demonstration of electrolytic hydrogen peroxide production at any given concentration from 20 to 99 at the site where it is needed with this flexibility of concentration range hydrogen peroxide could be used from sanitation bleaching to niche markets as propulsion fuels
technologydriven combinatorial therapy to rewire the spinal cord after injury

rewire will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord sc the proposed research program will equip nextgeneration scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury sci novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring to stimulate and guide regenerating nerve fibres across the lesion site and to promote functional reconnection with intact tissue additionally neuromodulation therapies can reactivate spinal circuits below a sci allowing people with chronic paralysis to regain voluntary control of walking in conjunction with rehabilitation neurological recovery was promoted that persisted without neuromodulation suggesting a rewiring of the sc as demonstrated in preclinical models to bypass an injury neuromodulation has been linked to brain signals to reestablish cortical control over spinal circuits by employing electrical nerve stimulation and robotic systems advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural wired connections the aim of rewire is to leverage all these technical and therapeutic breakthroughs in the framework of multiple phd projects that will continuously interact to converge toward effective combinatorial treatments for sci rewire will focus on three interwoven objectives i establish an international interdisciplinary and intersectoral educational network ii build an sci clinical data platform and iii position europe at the forefront of therapy for sci
adpribosylation and ubiquitination posttranslational interplay

posttranslational modification of proteins is essential in regulating proper cellular homeostasis the attachment and removal of the small protein ubiquitin ub is amongst others involved in regulating immune response cell cycle progression and proteasome mediated protein degradation the deconjugation of adenosinediphosphate ribose adpr on the other hand is essential in regulating dna damage responses and apoptosis adpribosylation and ubiquitination both dictate a highly complex signaling code and intriguingly these two ptm systems also communicate as ub was recently found to be adpribosylated on multiple different positions this new layer of controlling ubiquitination plays important roles in intracellular bacterial replication dna damage repair and tumor development understanding this fascinating posttranslational interplay and the role the different ubadprisotypes play in cell biology is crucial to develop novel strategies for therapeutic intervention in diseases such as infection diseases and cancers what are the mechanisms biochemical scope of proteinprotein interactions cell biological consequences and differences between these nonstudied ubadpr linkages i propose to study the entire system of dynamic adpribosylation of ub and explain the molecular details of the deconjugating enzymes explore the cell biological networks involved and exploit the key enzymes for inhibitor discovery enroute to future therapeutic intervention i will develop novel chemical methodologies and create a set of new substrates activitybased probes and assay reagents and use them to profile specificity and preferences of the involved enzymes study the interactions and pathways in cells and screen for small molecule inhibitors using my expertise in protein synthesis and chemical and structural biology i aim to unveil the details of this until now poorly studied but crucial hidden layer of posttranslational interplay in an unbiased manner
standardised automated safe and costefficient processing of endoflife batteries for second and third life reuse and recycling

one of the main challenges of eu battery sector to achieve the netzero emissions objectives for 2050 consists of keeping the added value of eol batteries enabling their 2nd life and improving recycling and recovery of critical materialsreinforce aims at designing developing and deploying a novel sustainable and highly efficient circular value chain serving as a reference for automated safe and costefficient logistics and processing of eol batteries from ev and stationary applications for repurposing and recycling reinforce will demonstrate all technological solutions and processes in a real environment at trl6 and the viability of the new circular value chain and business model innovations for eol battery repurposing this will be achieved by i an optimisation of collection and reversed logistics focussed on efficient diagnostics for early battery status cutoff decisionmaking and safe and smart transportation solutions ii safe and improved battery diagnostics and speedup discharge and energy recovery systems adapted to the current batteries stream iii adaptable and safe dismantling and sorting of eol batteries and components based on robotics machine learning and industry 40 including fully automated packtomodule disassembly and advanced moduletocelltoelectrode disassembly iv an innovative traceability system along the battery value chain based on a battery passport for the 2nd and 3rd life battery user v the definition of standardisation guidelines in line with current and upcoming regulations all revolving around vi robust sustainable circular business models demonstrating the application of reinforce proposition in a circular economy strategy and implement actions towards full market maturityfor this reinforce is bringing together a wide experienced consortium led by ine involving a team of leading industrial technology developers and providers rd centres and academic institutions and endusers at european level
fundamentals of formal properties of nonmanuals a quantitative approach

sign languages in addition to using the hands also use positions and movements of other articulators the body the head the mouth the eyebrows the eyes and the eyelids to convey lexical grammatical and prosodic information this linguistic use of the nonmanual articulators is known as nonmanuals contrary to current assumptions in the field of sign linguistics this project proposes the hypothesis that all sign languages use the same basic universal building blocks nonmanual movements but that each language is different in how it combines these building blocks both sequentially and simultaneously languages also differ in the regularity frequency and the alignment properties of the nonmanuals in order to test this hypothesis the project will investigate formal properties of nonmanuals in five geographically historically and socially diverse sign languages using data from published naturalistic corpora of the sign languages computer vision for extracting measurements of the movement of nonmanual articulators and a statistical technique of functional data analysis for a quantitative comparison of dynamic nonmanual contours this will result in the first quantitative formal typology of nonmanuals grounded in naturalistic corpus data the novel methodology proposed in this project requires testing adjustment and development which constitutes an important component of the project the developed methodological pipeline will be a secondary output enabling largescale reliable quantitative research on nonmanuals in future finally the established typology of formal properties of nonmanuals in the five sign languages will serve as basis for a crossmodal comparison between nonmanuals and prosodyintonation in spoken languages in order to separate truly universal features of the human linguistic capacity from the effects of the visual vs auditory modalities
industrygrade quantum memory links enabling the quantum internet

the prospect of a quantum internet interconnecting quantum computers sensors via quantum information networks qins promises to enable new technological societal breakthroughs quantum entanglement between pairs of particles enables the prospect of absolutelysecure communications and distributed quantum computing within the qin however quantum principles render classical techniques for extending range inapplicable a quantum internet thus requires an efficient means of enabling reliable quantum links qmlink builds upon our teams work within the eu flagship quantum internet alliance qia project in developing a quantum memory qm based upon lasercooled ensembles of cold atoms and quantum networking protocols leveraging this technology welinqs qm with a world record 90 storage efficiency makes quantum interconnection possible our ambitious project goal is to develop the worlds first industrygrade qm links for qins combining highefficiency long storage time with integrated frequency conversion for interfacing with optical telecommunication bands welinqs qm addresses the critical need for quantum repeaters essential for secure fast communication at long distances we have a welldefined plan to achieve trl6 while attaining storage times at least an order of magnitude beyond stateoftheart for highefficiency qm which will greatly increase the maximal ranges capabilities of qins we will integrate our qm link solution in the qin testbed deployed throughout the paris region parisregionqci to demonstrate our system at a trl6 level showcase our product to potential customers key qin industry players and gain invaluable insight towards realizing the quantum internet eic support will accelerate our translation of cuttingedge research into industrial products critical to european quantum sovereignty advancing towards applications of our qm in distributed quantum computing while creating highquality jobs for a digital europe
agroecology for weeds

weeds negatively affect the sustainability of eu farming systems with weed management relying to a large extent on herbicides the reduction of herbicide use and risk has become major policy targets of farm to fork strategy aiming to promote agroecology and the transition to sustainable and resilient farming systems good is a 4year project adopting multidisciplinary approach aspired to create and evaluate agroecological weed management awm systems and demonstrate that awm adoption enhances sustainability and resilience of cropping systems the main ambition is to foster the agroecological transition for weed management across europe livinglabs ll will be cocreated with stakeholders and established in 6 eu pedoclimatic conditions in both annual and perennial crops to promote awm practices in conventional organic and mixed farming systems the use and combination of cover crops along with several cultural practices the use of beneficial microorganisms and digital tools will be assessed towards the agroecological manipulation and management of weeds and the increase of crop productivity and farmers income the main outcomes include 1 the creation of an agroecological weed management network awmn 2 the development and combination of innovative and socioeconomically validated sustainable agroecological practices that will generate social economic and environmental benefits through the reduction or elimination of chemical inputs and optimized use of natural resources linked to the post eu 2030 targets 3 the digitalization of weed management 4 the enhancement of the agricultural systems resilience without jeopardizing productivity and profitability successful outcomes will be promoted through dissemination and demonstration activities and a webplatform for the training of farmers on awm systems a repository on current weed management methods and herbicide use and an awm toolbox to assist farmers decisionmaking for awm