Dragon09/odtu_chatbot huggingface dataset:
spatial control of antigenencoded supramolecular copolymers for robust tcell activation against cancer

nature uses a complex chemical language between cells and their environment to sustain life tcells critical players of the immune system constantly communicate and respond to environmental signals through cellfate decisions to protect against pathogens their function in the immune system is of particular interest for cancer immunotherapy where their activation and expansion can be harnessed to kill cancer cells low affinity cd 8 tcells are attractive because of their memory to prolong the duration of therapy but they are challenging to expand unlike their high affinity counterparts in this proposal i will explore the multimerization of tumorassociated antigens taas through the h2kbova peptide complex on supramolecular polymer scaffolds to potentiate the activation and expansion of lowaffinity cd8 tcells i will develop monomers that undergo kinetically controlled supramolecular polymerization in water and explore the potential to prepare block copolymers by modulating the monomer design with respect to hydrogen bonding and hydrophobicity supramolecular block copolymers will be engineered with domains of distinct sizes at the nanoscale to enable control over the taa presentation with respect to spacing and density additionally the effect of modulating ova peptide sequence using a library of h2kbova peptide complex outfitted supramolecular block copolymers with various peptide sequences i will map the potential for activation and expansion of low affinity cd 8 tcells importantly the major aim of this proposal is to develop strategies to prepare supramolecular block copolymers in water with bioactive units to broaden the application space of this materials class in the biological field
accelerating the discovery of highperformance electrocatalysts through artificial intelligence and robotics technology

catalysts are fundamental for almost all industry products as they accelerate and control the selectivity of chemical reactions as such they play a crucial role in mitigating the climate crisis to transition away from fossil fuels by utilizing co2 in electrochemical reactions to synthetize carbon neutral end products however catalyst innovation is lacking it takes about 20 years to discover a new catalyst with multimillion euros rd expenses to enable a carbon neutral industry in the near future dunia is revolutionizing electrocatalyst discovery with its autonomous artificialintelligence and robotic driven laboratory this breakthrough technology significantly accelerates the discovery process reducing timeframes by up to 90 and cutting costs by at least 6070 compared to conventional methods while building the largest and most reliable database for future electrocatalyst research as a result dunia is able to find highperformance catalysts that can utilize captured co2 in the production of valueadded chemicals and green fuels
holistic approach to enhance the recyclability of rareearth permanent magnets obtained from any waste stream

harmony project aims at strengthening the independency and the competitiveness of european industry enabling a resilience value chain of raw materials by developing and validating at pilot scale an innovative green and safe closedloop recycling process of rare earth elements rees from endoflife eol ndfeb permanent magnets the recycling loop encompasses the collection and dismantling of eol ndfeb magnets and weee scrap the recovery of ree metals through an indirect recycling process the production of recycled ndfeb powder via three direct recycling methods the manufacturing of magnets from the recycled powder and the validation of the recycled magnets in enduser applications collection and recycling steps will be implemented in 8 pilot plans reaching a final trl of 67 the combination of direct and indirect recycling technologies will allow dealing with any scrap containing ndfeb in any form sintered or bonded magnets the recycled ndfeb magnets will be used in the same applications as the magnets made from primary powder since they will exhibit comparable properties additionally they will be recyclable via the same routes a dissemination exploitation and communication master plan decmp will be developed to maximize the impact beyond the lifetime of harmony project harmony will build upon existing standards during the development of the novel products ensuring compatibility with market conditions and increasing transparency for prospective customers the economic environmental and social viability of these processes will be demonstrated via life cycle assessment lca social life cycle assessment slca and lifecycle cost analysis lcca furthermore social innovation including citizen dialogue policy issues standardization and ethics will be considered to overcome the nontechnological barriers that make difficult to introduce these novel technologies at the short term in the market
education policies that work a contextsensitive big data approach

in the last decades profound socioeconomic changes have posed unprecedented challenges to the traditional centralised model of stateprovided education this has led many countries to adopt neoliberal educational policies nlps promoting school autonomy competition and accountability as leverages for school effectiveness yet given increasing societal inequalities we are also witnessing a resurgence of democratic inclusive educational policies dips with egalitarian aims although these different policies can coexist they have so far been scrutinised separately edupol develops the first comprehensive comparative analysis of the interplay between nlps and dips by building on the concepts of policy configurations and contextspecific effects the project proposes a paradigmatic shift from the focus on what works to what combinations of policies work for whom and in which circumstances it pursues four key aims 1 to investigate the trends and diffusion of nlps and dips across the globe in the last four decades 2 to assess their effects on quality and equality in students cognitive and socioemotional competencies and civic engagement 3 to map withincountry schoolspecific policies 4 to uncover the heterogeneous effects of schoollevel policies across schools and territories edupol builds a novel macrolongitudinal dataset of educational policies and integrates insights from international repeated crosssectional data groundbreaking italian big data millions of student records textual data from school reports administrative archives satellite data student population panel data and qualitative interviews with key school actors to achieve its ambitious objectives by combining qualitative comparative analysis spatial panel regression flexible machinelearning techniques and causalinference methods the project will significantly advance our understanding of the conditions under which educational policies work
cooperative realtime experiences with extended reality

the mission of cortex is to bridge the divide between widespread videoconferencing tools and stateofthe art xrbased solutions democratising the uptake of nextgeneration extended reality telecooperation among a large number of industrial segments and smes to this aim our project will provide 1 full support for ar experience as extension of videoconferencing systems when using heterogeneous services end devices through a novel mediation gateway platform 2 resourceefficient teleconferencing tools through innovative transmission methods and automatic summarization of shared long documents 3 userfriendly and powerful xr experiences with instant 3d reconstruction of environments and objects and simplified use of natural gestures in collaborative meetings 4 fusion of vision and audio for multichannel semantic interpretation and enhanced tools such as dialoguing virtual conversational agents and automatic meeting summarization 5 full integration of iot devices in xr experiences to optimize interaction with running systems and processes 6 optimal extension possibilities and wide uptake opportunity through the delivery of the core system with open apis and the the organisation of open calls for extensions towards more technical modules and more use cases in various segments in order to ensure large adoption and fast scaling of our extended remote cooperation solution we will use the widespread teleconferencing solution rainbow from alcatel lucent enterprise as a backbone for our innovative extended reality based telecooperation concept which counts today more than 3 million users worldwide cortex will extend rainbow to allow for fully interactive xrbased cooperation and will be demonstrated in three pilots industrial production business meetings and remote training wide uptake will be guaranteed by financement of thirdparty projects to allow for more technical extensions wider usecases and deeper evaluation and assessment
the singlecentre ambiphile ligand concept cooperative systems for wastefree catalysis

the addition of ammonia to alkenes which could produce amines in a 100 atom efficient process has never been achieved by a molecular catalytic system and stands as a modern holy grail for the synthetic chemist alkyl amines a major chemical commodity are typically accessed through stoichiometric methods even employing toxic n1 feedstocks such as hydrogen cyanide the fundamental barrier to utilizing ammonia as an n1 feedstock lies in its activation with a high nh bond energy and a preference for acting as a neutral donor ligand in organometallic systems in order to employ ammonia in catalytic transformations new bondactivation concepts which address these fundamental pitfalls are essentialthe singambi project overcomes these challenges through the singlecentre ambiphile sca ligand concept drawing inspiration from cooperative activation protocols at play in enzymes and bimetallic complexes this concept defines noninnocent ligand systems which utilise highly reactive ambiphilic species from the forefront of lowvalent main group chemistry in combination with reactive transition metal tm centres sca ligands provide a platform for cooperative bond scission via yet unexplored mechanistic pathways this can drive facile ammonia activation directing nh bond cleavage towards the formation of tm hydride complexes key in overcoming previous shortfalls in the hydroamination of alkenes with this abundant small molecule ultimately we will expand this concept towards universal systems for wastefree alkene functionalisation catalysis through forming a deep understanding of the unique mechanistic pathways accessible through the sca ligand concept in designing developing and understanding numerous scatm systems the singambi project will develop a breadth of unique chemical tools for the promotion of cooperative bond activation and sustainable catalysis framed by the activation and utilisation of ammonia for wastefree access to commodity amines
on intelligence and networks

until recently most of the major advances in machine learning and decision making have focused on a centralized paradigm in which data are aggregated at a central location to train models andor decide on actions this paradigm faces serious flaws in many realworld cases in particular centralized learning risks exposing user privacy makes inefficient use of communication resources creates data processing bottlenecks and may lead to concentration of economic and political power it thus appears most timely to develop the theory and practice of a new form of machine learning that targets heterogeneous massively decentralized networks involving selfinterested agents who expect to receive value or rewards incentive for their participation in data exchangesocean will develop statistical and algorithmic foundations for systems involving multiple incentivedriven learning and decisionmaking agents including uncertainty quantification at the agents level ocean will study the interaction of learning with market constraints scarcity fairness connecting adaptive microeconomics and marketaware machine learningocean builds on a decade of joint advances in stochastic optimization probabilistic machine learning statistical inference bayesian assessment of uncertainty computation game theory and information science with pis having complementary and internationally recognized skills in these domains ocean will shed new light on the value and handling of data in a competitive potentially antagonistic multiagent environment and develop new theories and methods to address these pressing challenges ocean requires a fundamental departure from standard approaches and leads to major scientific interdisciplinary endeavors that will transform statistical learning in the long term while opening up exciting and novel areas of research
sustainable transitions action research and training in urban perspective

startup will engage in a doublesided process of taking action and doing research that promotes transformative change the project highlights the critical role of cultural heritage ch and the cultural creative industries ccis in socioeconomic postcrisis recovery and their potential to drive the transition towards a beautiful inclusive sustainable environment these principles align with the new european bauhauss neb core values which seek to engage citizens institutions and creative individuals as thinkers and changemakers in shaping a better future the project adopts the placemaking paradigm which promotes a bottomup smallscale and placebased approach in eight smallscale trials placemaking based on culture and creativity will be tested and refined cultural mapping and comparative case study research will further promote the knowledgebase for such interventions the trials mappings and case studies will form the empirical underpinnings of analyses of sustainable architectural design multilevel policy and governance and social economic and environmental impacts positive and negative of culturedriven placemaking these analyses in turn will form the evidencebase for startups final results and main outcome a european creative placemaking framework which is the policyoption startup will innovate the approach of the framework builds upon local actors in culture and creativity and aims at strengthening these actors as well as local authorities in building their future on the tangible and intangible cultural resources represented in the place the framework which aims to be a worldleading management tool hereby supports local economic development sustainability social cohesion and identity across europe but based on local cultural and creative professionals engaged in their art
wavefunction networks probe and understand quantum manybody systems via network and complexity theory

wavenets aims to establish a novel theoretical paradigm for understanding quantum systems centred on a network interpretation of manybody wavefunctionsongoing experimental progress motivates the need for a new theoretical approach in the field of quantum simulation and quantum computing probing capabilities have reached unprecedented levels with the ability to collect thousands of wave function snapshots with impressive accuracyhowever most of our theoretical understanding of such settings still relies on and relates to fewbody observables this has created a clear gap between experimental capabilities and theoretical tools and concepts available to understand physical phenomena the overall goal of wavenets is to bridge this gap by introducing a mathematical framework to describe wavefunction snapshots based on network theory wave function networks that will enable a completely new set of tools to address open problems in the field of quantum matterwavenets main objectives are to demonstrate that wave function snapshots of correlated systems are described by scalefree networks and classify the robustness of quantum simulators according to such to formulate methods for quantifying the kolmogorov complexity of manybody systems and propose an informationtheorybased characterization of topological matter and confinement in gauge theories to propose scalable methods for measuring entanglement in quantum simulators and computers as well as for their validationachieving these objectives will a provide unique insights into the information structure of quantum matter b enable methods of probing and controlling matter of direct experimental relevance thanks to the intrinsic scalability of networktype descriptions and c establish a new interdisciplinary bridge between quantum science and network and data mining theory that makes possible knowledge transfer between two mature yet poorly connected disciplines
explore your brain 20 a maximally effective usable and scalable growth mindset intervention to break through adolescents declining rates of motivation and school achievements

adolescence is a period of sharp declines in school motivation and achievement with negative consequences not only for the academic success and mental wellbeing of youth but also for teachers and parents an interesting target for intervention is adolescents implicit belief that their abilities are malleable growth mindset which has been shown to protect against declines in motivation and achievement and to boost resilience in school and beyond this poc builds on the innovative growth mindset intervention explore your brain eyb developed in the erc stg brainbeliefs eyb uniquely combines theoretical information about brain plasticity with an experience of influence over ones own brain generated using neurofeedback the results were very promising but the technology is still in applied research status and not yet easily usable by teachers in the classroom the main goal of this poc is to drastically increase the impact that we can achieve on academic motivation achievement and resilience of high school students by improving our prototype growth mindset intervention the breakthrough of the innovation depends on increasing usability objective 1 and scalability objective 2 to maximize the number of adolescents who can profit from the innovation to reach objective 1 a research development team including game designers and education specialists will iteratively develop and test explore your brain 20 eyb 20 adopting a usersasdesigners approach to reach objective 2 a business development team will develop a business plan for financially and logistically feasible largescale implementation of eyb 20after completing this project we hope to implement eyb 20 nationally as well as internationally at a large scale thereby protecting a maximum number of adolescents against declines in school motivation and achievements this benefits society at large because of higher educational attainment and mental wellbeing of the next generation
reconstructing paleolithic population dynamics using microstratified paleogenomic analysis

modern humans are defined and sustained by interactions and networks in paleolithic contexts reconstructing interactions and networks is limited to inferences based on material culture or direct evidence of biological relatedness but evidence on the latter in the form of human fossils is very rare still archaeogenetic research can formulate supraregional models for broad time periods based on only a few genomes by distinguishing ancient clades but not to the level of interactions between human groups of particular cultural complexes recently archaeological sediments and speleothems karstic cave formations have been revealed as a further genomic archive for past environments and past human populations initiating a new phase in archaeogenetic research these new archives have the potential to greatly expand the archaeogenetic record as they stem from ubiquitous environmental sources and they do provide the spatial and temporal resolution to zoom into population dynamics at the group level however what this ancient dna adna originates from and under what conditions it preserves over time are still open questions i here suggest placing this paleogenomic data into a microstratigraphic framework where individual depositional events are recorded in microscopic features to overcome these problems and to provide highresolution time series of population interactions using an interdisciplinary tool kit i will i reconstruct the source origin and deposition of sedimentary and speleothem adna in archaeological contexts ii identify ideal preservation contexts for this type of adna with a focus on infield assessments and iii extract genomic time series from archaeological sediments and speleothems i will apply this approach to upper paleolithic sites in georgia to reconstruct the relatedness of the people using individual sites over time and across contemporaneous sites set against regional expressions of climate and paleoenvironment change
resilient supply chains for europe

the resc4eu csa is organized around 4 key objectives 1 defining risk disruption and alerts models for the supply chains of 14 at risk industrial ecosystems 2 developing a holistic european value network for strengthening supply chains fostered by industrial clusters and strategic alliances 3 accelerating the adoption of advanced methods and technologies for sustainability and resilience through the use of a dedicated digital b2b platform thereby benefitting from platform based growth models through network effects and 4 demonstrating supply chain resilience of industrial ecosystems while also achieving climate neutrality and sustainability of economic processes the consortium consists of 6 industrial clusters that have immediate access to over 1000 smes two research institutes cover logistics supply chain risk modelling and product lifecycle analysis respectively two smes one orchestrating the outreach activities of the project and the other providing an open source multisided b2b supply chain platform derived from a horizon 2020 project complete the teamthe workplan is designed to first activate the smes in the 6 clusters and then engage them in three ways a to foster knowledge transfer early on between the more technologyaware smes and those interested in innovating their processes b to develop an actionable model for supply chain analysis that can be supported by the platform and will lead to immediate supply chain risk mitigation and resilience and c to create impact by fostering new paneuropean as well as crossregional collaboration using a mix of strategically planned physical meetings and largescale virtual communitybuilding activities among them resc4eu netzero industry academies the cluster organizations cover logistics and supply chains of ghgheavy industry wood and furniture advanced it and have in sum outreach into all 14 industrial ecosystems for which pilot initiatives will be launched