Dragon09/odtu_chatbot huggingface dataset:
making sense of communities of arms

this project is an ethnographic study of the everyday deployment of firearms and their societal impact it examines and compares the various ways firearms produce communities and focuses on groups that are overlooked in the field of gun studies such as gun owners associations and hunting clubs armies hypothesises that these communities are disruptive and transformative ones that exert tremendous power for an accurate understanding of firearms these communities must take centre stage armies spearheads a new research agenda that centralises these communities of arms as material affective and political ones that profoundly shape everyday life it asks how do firearms produce communities how do these communities relate to one another and what is their societal impact this question will be answered through a comparative and multiscalar analysis of such communities and their members in brazil germany and south africa and global communities such as international disarmament organisations due to the highly embodied sensational and affective nature of firearms armies will use a multisensorial ethnographic approach that comprises ethnographic methods that explicitly target the senses this approach prioritises embodied experiences perceptions and processes of knowledge making the team of four researchers the pi and three phds will be steered by an ethos of team ethnography that stimulates collaboration reflection and ethnographic imagination armies is innovative in terms of its theoretical methodological and contextual approach to firearms it will benefit the fields of political anthropology material culture studies sensorial scholarship and gun studies the high gain of this research is threefold 1 it reconsiders existing theories of humannonhuman interactions 2 it creates a novel methodological approach and 3 it will be groundbreaking sciencebased evidence for our public understanding of the role of firearms in our society
innate lymphoid cells and tissue adaptation to changing metabolic needs

border surfaces of vertebrate organisms are in constant exchange with their habitat host cell networks consisting of epithelial cells stroma and tissueresident immune cells continuously integrate signals from the environment a process by which an organism becomes better suited to its habitat ie adaptation our understanding of the molecular underpinnings of such homeostatic processes is in its infancy yet they are decisive for proper organ function recently we and others have identified homeostatic circuitry involving tissueresident immune cells in the small intestine facilitating adaptation to changes in nutrient cargo the goal of my laboratory is to capture these molecular networks and to investigate how their failure predisposes to diseases this proposal aims to systematically define the role of mucosaassociated group 3 innate lymphoid cells ilc3 and of the il22il22bp module in tissue adaptation to changes in metabolic need via their interaction with intestinal stem cells stromal cells and enteroendocrine cells eec answering these questions demands both focused and global experimental approaches as well as the use of new genetic models for targeting of ilc3 and for recording epithelial cell differentiation based on these considerations and on strong preliminary data we have devised 3 specific aims that will allow an unprecedented analysis of ilc3controlled tissue adaptation 1 to understand intestinal ilc3epithelial cell units regulating nutrient handling and systemic metabolism 2 to test the role of ilc3 in intestinal adaptation to increased metabolic demand during pregnancy and 3 to characterize a new immuneepithelial module consisting of eec and il22producing ilc3 we and others have demonstrated that ilc3 effector programs are highly conserved and are operative in humans thus the anticipated results will carry tremendous implications for the prevention and therapy of metabolic diseases
novel orally available immune modulator mp1032 with antisarscov2 and anticytokine activity

the current global covid19 pandemic has caused severe health and socioeconomic challenges despite significant improvements in the treatment of critical covid19 patients and advances in vaccine development there is still an urgent need for safe and effective earlyintervention treatments to reduce disease burden hospitalization time and mortality it is of critical importance to halt disease progression in early mildtomoderate stages our new drug mp1032 has a dual mode of action targeting two important mechanisms immune system overactivation and viral replication in the early development of covid19 its unique mechanism of selfregulation prevents immunesuppression which is critical for early intervention in combination with the oral availability favourable safety profile rapid and affordable production scaleup and potential to work against viral variants mp1032 is the ideal candidate for early treatment of covid19 which can also be used safely in highrisk patients therefore the impact project aims to clinically validate mp1032 in a phase ii trial for its ability to stop covid19 disease progression the outcome of the project shall serve as a basis for followup rapid phase iibiii development and market registration four international smes will work together in the impact project to achieve the objectives 1 to demonstrate the efficacy of mp1032 in hospitalized covid19 patients 2 to demonstrate the effect of mp1032 on current sarscov2 variants 3 to develop a gmpcompliant production scaleup process for mp1032 4 to ensure that the clinical development plan is in line with regulatory requirements and 5 to collaborate with existing eu research networks we have 29 clinical sites on board and the required expertise for upscaling gmp manufacturing and regulatory preparation is available ensuring that by october 2022 mp1032 will be ready to progress to phase iibiii trials
nanoscale spinwave rf filters and multiplexers for 5g communication systems

our everyday life is unimaginable without wireless information and communication technologies since 2019 5g digital systems offer improved speed bandwidth and decreased energy consumption mobile operators invest 160 billion worldwide in the deployment of 5g each year over the last decades rf filters based on surface acoustic wave saw occupied the entire market but their usage for 5g highband 26 ghz in eu is impossible moreover the utilisation of bulk acoustic waves baws is still left to be explored due to their significant damping challenges with confinement and complex fabrication the solution is offered by the propagating excitation in the spin system of a solid magnetic body spin waves sws which can efficiently replace acoustic waves in the rf devices for all frequency bands the key advantages of sws are i frequency range from 1ghz up to hundreds of ghz ii manufacturability of sw transducers using conventional photolithography iii strong confinement of sws and iv additional nonlinear functionalities the erc stg magnoncircuits finished with utmost success 40 articles and delivered the methodology and knowhow for fabrication and characterisation of magnonic nanostructures explored sw physical properties in them and identified robust reliable and efficient phenomena for applications in the 5gspin project i will develop fully functioning bias fieldfree and industryready swbased rf filters and multiplexers for mid and highband 5g communication systems
buildingintegrated userempowered flexibility trading

bluebird buildingintegrated userempowered flexibility tradingwith the objectives of the green deal in mind bluebird aims to tackle the advantages derived from an increased use of flexibility assets in the electricity domain leveraging ai and data solutions bluebird will deliver a comprehensive and validated toolset to fully allow competitive adoption of buildings as energy flexibility assets supporting smooth integration of services towards energy market players ie tso dso aggregators while maximally aligning with endusers ie building managers occupants requirements and acceptance criteriabluebird trials will take place in seven largescale pilots in six countries spain belgium poland austria denmark and germany these trials will include the validation of enduser and beneficiary acceptance using socialscience methodsto foster replicability bluebird will offer a package of lessons learned and recommendations for future adoption this will include suggestions for feasible winwin industrial partnerships and guidance on ecosystem sustainabilitythese ambitious objectives will be achieved by a consortium of experienced and highly complementary partners from research institutions industrial sectors public authorities and ngos across eight european countries
cocreating strong uptake of remedies for the future of our oceans through deploying plastic litter valorisation and prevention pathways

the project is built around the three main pillars of monitoring plastic litter its collection and valorisation and of course the prevention of the distribution of nondegradable plastics we will do so by strongly building on former projects addressing these topics and by connecting to previously identified major initiatives active in this area for us the most promising aspect is the activation and necessary participation of citizens affected by plastic pollution directly on the shorelines we will guide them to becoming plastic entrepreneurs with a deeply rooted knowledge base and the right tools to start their own businesses through the valorisation of collected plastic litter and the provision of zerowaste solutions to all actors we plan to employ 4 breakthrough innovations per pillar monitoring collection prevention that are neatly interwoven building upon each other to create an even better whole we will test these solutions in 8 demonstration sites in 8 mediterranean countries and after validation scale them up in 33 more sites with the potential to be launched across the whole mediterranean in parallel we will run two open calls to third parties to attract more solutions for implementation following our same methodology allinall we plan to map out 170 km2 for plastic litter reach circa 100000 citizens collect around 400 tons of plastic waste and build up plastic prevention pathways through scaling and replication for an equivalent of 3700 tons of plastic
open researchers 202223

open researchers 202223 is the 11th andalusian experience in the european researchers night the project is designed to increase the awareness and perception of research as a solution to the numerous challenges faced by citizens all around the world as well as showing science as the way to achieve the goals of the horizon europe missions excellence science for boost a greener smarter and healthier future in europe with and for citizenship is the main idea of the project it has been conceived at a time when the ue has just launched horizon europe in order to join efforts to face the greatest societal challenges that europe is facing understanding that science is present in our daily lives it should be accompanied by a scientific culture that will prepare citizens to a reality full of challenges it is essential to promote youth interest in science by opening it to the general public through researchers in an accessible way fundacion descubre will coordinate this project based on its experience through the last decade working with relevant projects and in its consortium experience in the previous night projects the consortium is composed of 9 andalusian universities the spanish national research council csic andalusian foundation progress and health and the royal botanical garden of cordoba the projects major strength is the numerous activities taking place on streets theatres and historical buildings of the 8 andalusian cities with a high mobilization of researchers and collaborating institutions to reinforce this partners will consolidate a strong programme of activities at schools the european dimension will be underlined by the active involvement of researchers funded by eu and msca fellows in the event gender balance will be guaranteed in researchers as well as the rri for designing inclusive and sustainable ri the project includes a european collaboration to design a set of shared activities linked to horizon europe missions
fifth generation services hub for european union governmental satellite communications

satellite communication networks in europe have been in the market for more than 40 years with consolidated capacity to connect remote areas and represent an essential tool for state members therefore it is evident that there is a need to allow the satellite operators to manage govsatcom users efficiently with the overall available resources this project aims to evolve the flagship european initiative govsatcomhub to improve the flexibility of satellite network operators in allocating their resources to the needs of govsatcom users this goal will require the development of a new interface between the ghub and the 5g core network entities and microservicebased services interacting among them to provide network management tasks moreover the 5ghub project will address the interoperability issues allowing the govsatcom user terminal to connect to different space assets eventually including terrestrial systems this project aims to validate the ghub functions in three trials with the initial development of a unified 5g ntn terminal in ku and x bands the trials will aim to verify the system performance in terms of resource allocation quality of service provision and capacity to switch communication traffic steering from the satellite network to the terrestrial network in a way that is unnoticeable to the user these trials will be based on critical scenarios of emergency management where there is the need to coordinate teams in remote areas where satellite systems mainly provide connectivity the interoperability of different satellite operators will also be investigated in this context
next generation bioactive nanocoatings

nova aims to provide a comprehensive approach to antimicrobial coating development by creating an effective feedback loop between coating design end use and functionalsafety testing this consists of combinatorial optimisation of 4 coating technologies i light activated based on uv upconverters nanoscale photocatalysts and hydrophobic carbonbased quantum dots and ii contact killing biopolymers chainlength controlled supramolecular assemblies of polypeptides and polysaccharides the coatings will be adjusted in a use case driven specifications for having the capacity to coat different substrates in the same environment such as hospitals in order to guarantee safety for citizens and environment the coatings will be developed with a safe and sustainable by design ssbd approach taking into account the environmental risks nova will develop advanced tissue tests and immunotoxicity tests optimized for coatings to provide tools for the regulatory bodies an in depth analysis of future coatings for demonstrating practical efficacy reallife mimicking innovative antimicrobial tests will be developed the validated coatings will be developed for commercial exploitation by upscaling using the capacities of the industrial partners for easier adoption specific coating application devices will be designed within the project finally the experimental data generated within the project together with the historical data of coating developers of the consortium will be used for developing predictive models using machine learning methodologies for expedited coating development methodologies in the future nova aims to bring high efficiency ecofriendly stable coatings demonstrated within the project in 4 main use cases textiles paints tactile electronics and frequently touched hard surfaces with high hygienical relevance like eg in hospitals and common hygienical relevance in public spaces which can be then expanded for more widespread utilization
prediction optimisation for scheduling and rostering with cmppy

in todays world organizations across various industries face the challenge of efficiently scheduling their production processes and rostering their workforce optimally however despite consistent improvements in combinatorial optimization software for scheduling and rostering the complexity of this task continues to grow due to uncertainty about multiple factors such as employee availability demand fluctuations supplier variability variable prices the impact of weather and the increasing need for energy efficiency machine learning can be used to make estimates about these uncertain factors but the real challenge is in integrating predictions and the optimization of scheduling and rostering problems or more precisely that predictions and optimization over these predictions need to be developed and evaluated together while many combinatorial optimisation solvers for solving scheduling and rostering exists including constraint programming and mixed integer programming solvers few of these solvers can be easily integrated with machine learning libraries futhermore in a machine learning pipeline the requirements for the solver change what is needed is a framework for solving prediction optimization problems that bridges the machine learning and combinatorial optimization solving tools it should allow actors to discover what a datadriven approach can signifigy to their scheduling and rostering problem by allowing them to easily experiment and prototype both on the learning side the solving side and the combination of the twoin my erc consolidator project conversational humanaware technology for optimisation we started building such a library cpmpy we notice an increasing industrial interest in solving prediction optimisation problems but a lack of unified tools to do so this proposal sets out to increase the technological readiness level of cpmpy from trl 4 to 6 and to demonstrate its potential and align it with industry needs
carinata and camelina to boost the sustainable diversification in eu farming systems

carina is built on a multiactor consortium and participative decisionmaking process through mutual learning transparent communication and inclusive multiperspectives and transdisciplinary engagement from the proposal clearly emerges the importance of social innovation as the nerve center for the evolution of the whole project nine lighthouses 5 living labs and 9 policy innovation labs will be established across europe playing a leading role in the cocreation of carina innovation actions carina focuses on new sustainable and diversified farming systems including 2 new oilseed crops carinata and camelina able to provide multiple low iluc feedstocks for the biobased economy we firmly believe that a participatory approach is necessary for successfully scalingup innovative farming systems engaging farmers and other stakeholders in jointly developing solutions under specific environmental technical and social conditions has been highly considered in carina we estimate about 3m farmers being potentially reached by carina thanks to the direct cooperation with its partners to find a broad consensus by primary producers a new crop should enable to promote and harness biodiversity be easytogrow and technically feasible within current cropping systems carinata and camelina fully meet these requirements able to successfully grow almost everywhere in europe and in northern africa carinata and camelina provide high quality oils that will be transformed into innovative biobased products bioherbicides bioplastics the coproduct from oil extraction is a proteinrich cake which will be valorized as animal feed and in a multitude of high addedvalue products exploiting the mucilage and glucosinolates contained within carina capitalizes on a highly experienced team of 20 partners 6 affiliated entities from 13 eu and associated countries italy france spain germany greece slovakia bulgaria poland uk serbia tunisia morocco switzerland
from solar energy to fuel a holistic artificial photosynthesis platform for the production of viable solar fuels

refine develops and demonstrates a system of artificial photosynthesis by combining both dark and lightdependent reactions for the direct production of high energy density and essential chemicals such as alcohols to achieve this a direct hydrogen storage into hydrocarbons through co2 capture and transformation in an advanced biorefining system is proposed in this hydrogen produced by water photoelectrolysis is combined with captured co2 and directly fed to biocultures that selectively produce isopropanol and butanol as high energy solar fuels and the only energy input to drive this radical technological system is sunlight to realise and bring to the market such a system of artificial photosynthesis it is necessary to converge the fields of materials science biotechnology engineering and social sciences the project organisation is multicentred and operates at different levels from raw materials supply considerations societal acceptance materials engineering and nanostructuring to device assembling and applicability the true converging nature of refine provides a holistic groundbreaking approach that addresses major challenges of our modern societies such as the extensive co2 emissions and inability for efficient and widely accepted co2 recycling the vision in refine extends well beyond the 4year activities proposed in this application still refine is the seed for a multidimensional approach to critical scientific and societal challenges
proteasomal degradation of toxic intracellular amyloidbeta protein by nanobodyenabled proximity to ubiquitin ligase

the amyloidbeta a protein arises from the sequential proteolytic cleavage of a precursor protein app the accumulation of a oligomers has been regarded as the causal factor of alzheimers disease ad basal metabolic production of the a peptide is typical in healthy people and its production rate is normally lower than its rate of clearance in ad the uncontrolled accumulation of toxic forms of a stemming from problems in its clearance and degradation results in memory loss chronic neuroinflammation and neurodegeneration ad is a leading cause of disability and death both in europe and the world and currently has no cure or clinicallyproven diseasemodifying therapies there are over 10 million new cases of dementia each year worldwide up to 80 of which are due to ad implying one new case every 32 seconds in europe about 10 million people currently suffer from this disease and about 50 million in the world with these estimates projected to double by 2050 thus the identification of novel diseasemodifying therapies has become very critical to eradicating ad from europe and the world my project proposes a radically novel approach in the ad field of utilizing the bodys cellular waste disposal system to selectively degrade a peptide the causative agent of ad this is in sharp contrast to the current approach of immunization against the a peptide which has repeatedly failed to yield any cure or diseasemodifying therapies for adthis project will aim to identify the specific cytotoxic a peptides responsible for neuroinflammation and neurodegeneration in human induced pluripotent stem cells and target these peptides for degradation by the ubiquitin proteasome system emphasis will be on the cytotoxic a peptides of intracellular origin as emerging targets in ad this research will be conducted at the university of helsinki finland followed by a nonacademic placement at roche diagnostics gmbh