Dragon09/odtu_chatbot huggingface dataset:
a novel approach for modelling the human nosebrain axis in vitro

olfactory neurons allow circumventing the bloodbrain barrier making this route particularly interesting for the noninvasive intranasal treatment of brain diseases alzheimers disease moreover commensal nasal microbes present in the respiratory region the major surface of the nasal cavity are assumed to induce healthpromoting effects via metabolites as the gut or skin microbiome does these complex nasal hostmicrobiome interactions are emphasized when considering that olfactory neurons sense bacterial metabolites like odorants and that a loss of smell is associated with an early stage of brain diseases demonstrating the importance of the human nose nosebrain axis its mechanisms are incompletely understood due to the use of currently available oversimplified 2d in vitro as well as animal in vivo models animal models provide highly valuable insights into causeeffect relationships but translation to humans is challenging thus within the microsense project we are proposing to build an advanced bioelectronic 3d model of the human nosebrain axis urgently needed for a better understanding of healthy nose physiology this 3d bioelectronic platform will connect the recently developed 1 etransmembrane device hosting a respiratory nasal organoid and nasal microbes 2 microelectrode arrays with affixed intact olfactory tissue and 3 patchclamp setups for specific olfactory neuron studies integrated biocompatible pedotpss electrodes enable noninvasive monitoring and recording of nasal hostmicrobiome interactions by measuring epithelial barrier integrity and olfactory neuron firing in real time pedotpss scaffolds compartmentalize the etransmembrane device for connecting with meas and patchclamp setups enabling to study drug and metabolite uptake along the brain axis genetic and metabolic profiling of the genderspecific nose model will pave the way for optimized intranasal drug delivery targeting olfactory neurons and the nasal microbiome
achieving resilience through manufacturing as a service digital twins and ecosystems

the accurate project aims to boost the competitiveness of european manufacturing companies and value chains by improving their sustainability performance stability resilience and ability to manage unforeseen events to achieve these benefits accurate will develop innovative approaches and deliver an integrated set of results culminating intoa humancentric decision support system offering a better understanding of the impact of unforeseen events on manufacturing and industrial networks providing timely optimal and robust manufacturing supply and value chains design planning stress testing reconfiguration and recovery and improving their circularity and sustainability performancesa manufacturing as a service framework covering multiple critical supply and value chains leveraging data space technologies as well as multiscale and multilevel digital twins and cosimulation delivering swift adaptation capabilities of logistics and production that are technically and economically viable an open standardbased federated trusted data space and ecosystem integrating data flows models and tools across actors in manufacturing value chains creating smart manufacturing networks empowering humans and organizations to share valuable information and collaborate on maas solutions while retaining full sovereignty over their sensitive data and intellectual propertyaccurate results will be validated in 3 pivotal use cases covering multiple key european industrial sectors and value networks aerospace automotive biotech energy medical mobilitythe accurate consortium acknowledges the transformative potential of data spaces and ecosystems in revolutionizing business models and value propositions and will leverage these technologies and approaches to achieve impact create resilient manufacturing networks instigate deep innovation and accelerate results adoption
consequences of warmingdriven vegetation change for arctic carbon cycling and feedbacks to the global climate system

arcticedge will identify the consequences of warmingdriven vegetation change for the functioning of arctic ecosystems particularly the cycling of carbon and the impact on the global climate the arctic is the fastestwarming region on earth and arctic soils contain more than double the amount of carbon currently in the atmosphere changes in the vegetation can influence whether this carbon is released into the atmosphere thus contributing to additional climate warming or stored in soils and plant biomass until now we have lacked the ability to scale up from sitespecific localscale studies to generalizable vegetationfunction relationships relevant for the entire arctic arcticedge will 1 quantify the relationships between widelymeasured plant functional and phenological traits and three key ecosystem processes related to global carbon cycling litter decomposition primary production and fire dynamics using field and laboratory experiments 2 predict the rate with which these traits are likely to change in response to warming by identifying the relative contribution of turnover in species identity shifts in abundance phenotypic plasticity and genetic differentiation to trait variability and change over time 3 determine the contribution of arctic vegetation change to globalscale vegetationclimate feedbacks by combining knowledge from aims 1 and 2 with multidecadal records of vegetation change and responses to experimental warming and precipitation at hundreds of locations across the arctic and 4 produce quantifiable outputs that will feed directly into dynamic global vegetation and earth system models to determine the consequences of arctic vegetation change for the global climate the knowledge generated by arcticedge will contribute both to our theoretical understanding of how plants influence and are influenced by their environment as well as inform urgent efforts to project future changes in the global climate with greater precision
conference on research and innovation in leveraging technology to strengthen the eu competitiveness in life sciences

the project conference on research and innovation in leveraging technology to strengthen the eu competitiveness in life sciences lifescience4eu aims to organize a conference during the polish presidency of the council of the european union scheduled for 1516 may 2025 in krakw this event will spotlight the integration of advanced technologies to address healthcare challenges and improve global quality of life key objectives include aligning with eu health priorities to build a resilient and independent health sector fostering collaboration across research development regulatory bodies and patient advocacy groups and promoting innovations such as digital health ai and biotechnology the conference will explore strategies to overcome regulatory barriers enhance local healthcare manufacturing and scale emerging technologies additionally it will create a platform for networking knowledge exchange and the dissemination of best practices to maximize the impact of healthcare innovations and foster a collaborative ecosystem across europe
realtime monitoring networks and transport emissions for tailored zero pollution action plans in european cities

the transport sector is a major contributor to environmental degradation including air and noise pollution that have negative effects to ecosystems and human health this is particularly critical in urban areas where the confluence of transport emissions and high population density result in adverse health impacts and substantial economic burden the upcoming changes in the transport sector will be critical to reach targets set by the eu green deal the zero pollution action plans are essential tools to reduce pollution at many different levels through cocreation with stakeholders net4cities will facilitate the realization of the zeropollution vision by 2050 the backbone of net4cities is this transdisciplinary approach in which the consortium members will engage with the partner cities including ports and airports to jointly produce new knowledge and ensure relevance uptake and maximize transferability and exploitation during the project air and noise pollution monitoring infrastructure will be advanced and expanded in 11 european cities including transportation hubs such airports and ports to conform with upcoming directives and provide data for health impact assessments the activities are designed to have longlasting impact through both mid and longterm pathways providing a roadmap for greater uptake in european cities by offering tailored transferrable evidencebased support for implementing effective management strategies for reducing transportrelated emissions the main project results will be consolidated in the net4cities studio which will provide 1 a webbased interface with realtime maps and information to raise awareness and 2 a support tool for policy decisions that will provide guidance for operationalization and recommendations of solutions that consider innovative technologies such as dynamic traffic management systems and inclusion of naturebased solutions in overarching policy designs
revealing the physics of switching mechanism in 2d materials based memristor devices 2dmem

one of the most promising nonvolatile memory devices and a building block of braininspired neuromorphic computing architectures is memristors the advent of twodimensional materials 2dms has opened a plethora of opportunities in realizing ultrascaled device dimensions for future logic and memory applications despite different hypotheses proposed in the literature mainly based on analytical models significant debate is still ongoing demonstrating the need for a systematic and atomicscale study 2dmem aims to reveal the fundamental physics lying behind each step of device functionality eg set and reset 2dmem builds on the complementarity of my strengths on investigating the electronic properties of 2dms and simulation expertise and infrastructure at the host institution tyndall where access to a large interdisciplinary suite of experimental data on the fabricated 2dm memristors is uniquely available 2dmems specific objectives are to exploit the experimental data of 2dm properties and to incorporate realistic material and device features into crossbar structures by employing an advanced simulation platform my career development will benefit from the supervision of dr lida ansari with the mentorship of profs paul hurley stephen fahy and dr farzan gity who are established research leaders at tyndall and at irelands materials research center amber through this fellowship i will develop my scientific transferable and management and leadership skills these skills are essential for achieving my primary career objective of developing into an independent research leader and will increase my employability in the academic sector this msca fellowship also creates a unique starting point for me to directly interact with intel who have expressed great interest in this project through their rinr at tyndall this will open up additional possibility of leading impactful research projects and fostering industryacademia collaborations
harmonised practices regulations and standards in waste management and decommissioning

the project aims to establish and clarify the benefits and added value of more aligned and harmonised regulations and standards for prioritised topics related to decommissioning and initial phases of radioactive waste handling including shared processing facilities between member states msthe project has a twophase approach first engaging with stakeholders to assess needs and proscons for harmonisation and identify priority areas for deeper analysis wp2 the second phase will pursue deeper engagement with stakeholders to further assess the highest ranked priority areas in work packages wp focusing on i cross border services and cooperation wp3 ii circular economy wp4 and iii advanced technologies wp5 these wps will review international practices capture lessons learned and assess opportunities wp6 on regulatory framework will identify regulatory differences between ms and evaluate strengths weaknesses opportunities and threats associated with harmonisation while quantifying the benefits of aligned regulations and proposing harmonisation methodologies the project will support coordination between stakeholders enhance existing commitments to facilitate sharing and exchange of knowledge and experience develop strategies for shared treatment and storage facilities cross border services and cooperation and explore additional mechanisms to build capacity in ms assess and clarify the benefits and any disadvantages of harmonisation deliver stbased solutions and share best practices by engaging and supporting coordination between different actors through the tsos and regulators define conditions and opportunities of a high safety circular economythe action will reinforce the activities of the eurad predis and share projects while encompassing ms national programs and the wider european community including ie erdo ensreg wenra iaea oecd nea igdtp snetp digidecom
boridederived highly efficient material for green hydrogen generation and znair battery

the world energy demand is expected to grow by more than 25 by 2040 according to the world energy outlook by the international energy agency to tackle this significant and urgent challenge new materials with engineered properties for energy applications are required hydrogen h2 production by water electrolysis green h2 has received great interest as an alternative sustainable and clean energy technology for instance the green h2 is very crucial for the european commissions net zero emissions scenarios for 2050 to achieve green h2 this technology should be coupled with intermittent and renewable energy sources and thus the energy storage devices are involved in the green h2 production system due to its high energy density and environmentalfriendly the zincair battery is regarded as important energy storage device in the near future but the lack of satisfactory cheaper bifunctional electrocatalysts ecs for hydrogen evolution reaction her and oxygen evolution reaction oer for water electrolysis and the lack of bifunctional air ecs for oxygen reduction reaction orr and oer are the main challenges for both these technologies the stateoftheart ecs are based on noble metals whose application at a large scale is limited due to their high cost and scarcity consequently the development of highly efficient ecs without precious metals is urgent current strategies for the development of desirable earthabundant materials are often limited because of the poor electron transfer low conductivity poor stability and small surface area of the active materials to tackle this challenge we aim 1 to develop hybrid materials based on earthabundant metals derived from boride and highly conductive carbon by chemical reduction and pyrolysis methods 2 to study their structureproperty relationship and finally 3 to understand the degradation mechanism which is crucial for designing the materials with outstanding stability
predicting nucleation to support nextgeneration microtechnology diffuse interface fluctuating hydrodynamics and rare events

there is a noticeable trend in simulations of fluid processes to try to be as much as possible multiscale ie to carry out simulations from molecular scale to hydrodynamics this is made possible by the unprecedented capabilities of parallelization gpus and supercomputing in general which allow insilico representation of fluids with billions of degrees of freedom despite this formidable scientific progress one crucial aspect still hinders a quantitative description of phase transitions the way a phase change originates namely the nucleation process the elusiveness of this process stems from its strong multiscale nature involving both atomistic and hydrodynamic scales more importantly as nucleation is a rare event it inherently involves a broad spectrum of time scales the most ambitious feature to be characterized it is also clear that the next technological breakthroughs in phasechangebased microtechnology are limited by the inadequate comprehension of phase transitions as a matter of fact the fluid dynamic design of frontier microtechnologies is mainly based on empirical ground promising twophase cooling strategies for microelectronics phasechangedriven microrobots synthetic microtrees and bioinspired microstructures for condensation control are typical examples meeting these fundamental and technological needs the objective of enucl is to provide a holistic understanding of phase change processes in fluids which shall describe both the nucleation inception and its coupling with multiphase hydrodynamics pursuing this goal enucl advocates a paradigm shift in fluid modelling by combining innovative rareevent techniques based on large deviation theory with the diffuse interface and fluctuating hydrodynamics modelling of multiphase flows this framework could be a game changer in multiphase fluid dynamics and it will allow the first insilico highfidelity trials of archetypal microtechnologies
biodiversity conservation to mitigate the risks of emerging infectious diseases

biodiversity loss in hotspots of biodiversity is among other socioecological factors key to understand prevent and react to future pandemics however despite this knowledge the current covid19 crisis highlights the limitations of the implementation of one health approaches a main limitation is the lack of contextadapted solutions that stakeholders could easily implement on the fieldto overcome this bcoming will build on past international projects to coconstruct innovations with all stakeholders of biodiversity hotspots to reduce the risk of infectious disease emergence through biodiversity conservation and disease surveillance strategiesthe activities of the project will be implemented in europe and three tropical biodiversity hotspots in southeast asia west africa and the caribbean and will have the following expected impacts bcoming will lead to a better understanding of the mechanisms underlying the impact of biodiversity on the risk of infectious disease emergence participatory tools developed will facilitate the design of contextadapted biodiversity conservation and restoration strategies that reduce zoonotic risk the surveillance strategies and pathogen detection tools developed will improve the capacities to detect emergences and stop future epidemics before they can turn into pandemicsthe consortium constitutes a strong multiactor group of partners with a history of successful cooperation including academics from biomedical environmental and social sciences private companies ngos local and international stakeholders who bring together the wide range of disciplines and expertise required to reach all the expected outcomes of the callthe embedment of bcoming in the prezode initiative will help to scale up the project innovations and disseminate cuttingedge socioeconomic environmental strategies
identifying biobased solutions for waste management applicable to humanitarian sector

as the solid waste management crisis is growing in its urgency humanitarian aid practitioners are faced with the question of how to manage environmental challenges linked with aid that is being shipped across various humanitarian settings one of the sound solutions how to address this challenge is to open up a streamline of cooperation between humanitarian aid operators and the biobased sector allowing them to explore the application potential of biobased products systems and innovative technological solutions bio4human aims to contribute to the identification of biobased solutions for solid waste management that have the potential to be applicable in various humanitarian settings to achieve this goal bio4human will conduct a scoping exercise that will come up with a list of solutions but also identify existing supply chain gaps following that it performs life cycle assessments of the proposed solutions and evaluates their applicability with regard to socioeconomic and governance aspects to explore if solutions fit the purpose of key solid waste management stakeholders and to explore the possibility of their acceptance by the community local businesses and local authorities bio4human conducts a feasibility evaluation process in 2 african locations simultaneously the project will develop a replication roadmap that will contribute to the future replicability of the solutions identified altogether all of the bio4humans actions will help to improve ways of addressing waste management challenges under humanitarian contexts and to the reduction of waste littered in the environment in the long run bio4human is expected to contribute to the development of innovative and sustainable value chains that will benefit consumers and citizens in europe and beyond
understanding the melting dynamics in turbulent flows

dissolving eroding and melting processes are ubiquitous in everyday life nature science and technology the challenge is to accurately predict the melting or dissolution rate eg of an iceberg or glacierrelevant for climate changeor of solid reactants in chemical reactors important to accurately control reaction rates and temperatures current predictions for the melting of glaciers are often off by a factor of 100 and different melting models show inconsistencies no general consensus of the cryospheric modeling has been reached yet the difficulties in describing melting and dissolution stem from the multiscale nature of these processes micrometers to kilometers and the interaction between thermal solutal and viscous boundary layers and their complex interplay with the continuously reshaping boundary a common belief is that melting always smooths the shape however from examples in nature and from theoretical analysis it is clear that flows around melting or dissolving objects can create a rough dimpled surface dramatically increasing the difficulty of accurate predictions the objective of the project is to solve the gap in understanding and develop a quantitative understanding of the heat and mass transfer and the resulting melting and dissolution dynamics of fixed surfaces and freelymoving objects in turbulent flows from a fundamental fluid dynamics perspective to do so we will perform highly controlled lab experiments and numerical simulations which allow for a combined experimental numerical and theoretical approach to reveal the underlying mechanisms of the melting and dissolution dynamics unique experimental flow facilities the latest 3d optical measurements techniques and advanced highperformance numerical schemes will allow for a onetoone comparison between experiments and simulations given the societal relevance of climate change and the burning technol