Dragon09/odtu_chatbot huggingface dataset:
tokmat truth objectivity and knowledge rethinking the social construction of mathematics

like all human undertakings mathematics is pursued promoted and developed by socially and culturally situated practitioners immersed in the complex collectivities of their communal practical and institutional affiliations however while few would oppose viewing any other major artistic social political or religious undertaking as socially constructed social constructivism in mathematics specifically regarding the notions of truth and objectivity remains highly contested among historians and philosophers of science and mathematics the tokmat project uses intuitionism in order to develop a new technique for understanding the concept of truth in mathematics this technique will be based on a conceptual analysis of the ideas of truth realism objectivity and knowledge in mathematics through the prism of social constructivism intuitionism presented an alternate mathematical framework to classical mathematics that viewed mathematical entities as creations of the mind as intuitionism acknowledges the social constructivists claim that truth is a wholly human construction it is a springboard towards a widereaching rethinking of the main constructivist account of mathematics as a nonmainstream mathematical school whose ideas are still being discussed intuitionism is a springboard towards exploring the social organization of scientific knowledge and its impact on our understanding of concepts like truth and objectivity the project therefore brings together the history sociology and philosophy of mathematics in order to provide new ways of understanding the notions of truth and objectivity in mathematics as shaped by both external and contextual elements in doing so this project aspires to contribute to the heady debates on epistemology philosophy of mathematics and the social constitution of warranted knowledge
structural neuroimaging in adhd brain development from childhood to adulthood

attention deficit hyperactivity disorder adhd is one of the most common neurodevelopmental disorders with 5 of children and 25 of adults being affected core symptoms include inattention hyperactivity impulsivity and cognitive dysfunctions causing a significant burden in multiple domains of daily life delayed brain maturation in childhood and adolescence is suggested as neurobiological underpinning of adhd but longitudinal studies are scarce and have partly revealed divergent results the aim of the present project is to investigate the neurobiological mechanisms underlying the developmental course of adhd within an independent closely monitored and wellcharacterized longitudinal sample dutch neuroimage cohort brain anatomical scans of initially 1069 children with and without adhd will be analysed with regard to the development of cortical thickness surface area and subcortical volumes from childhood over adolescence into adulthood an additional ultrahigh field 7 tesla brain scan acquired in young adulthood will be used to precisely investigate cortical myeloarchitecture all measures will be analysed with respect to clinical outcomes that is comparing patients with persistent adhd patients with adhd in childhood who have remitted into adolescence or adulthood and healthy controls to further understand what mediates or moderates individual differences in adhdassociated brain maturation the role of genetic and environmental risk factors will be considered this project is expected to lead to an enhanced overall picture on the developmental trajectories of adhd identification of interindividual differences between individuals with persistent adhd and those who recover as well as influencing factors will not only provide further insights into the neurobiological underpinnings of adhd but could also have high value for individualization and optimization of treatment approaches
euchinabridge building roadmaps to industrial decarbonisation and green economy through euchina cooperation

euchina bridge will support the transition to a climateneutral and resilient society in both europe and china by jointly advancing knowledge on technology innovations and roadmaps for decarbonising energy intensive industries cocreating innovative modelling by combining cuttingedge bottomup and integrated assessment modelling to quantify netzero sustainable pathways and developing the most updated and comprehensive emissions data it will intensively engage relevant stakeholders from both regions enhancing dialogues and fostering mutual learning among policymakers industries and experts it will deliver two opensource euchina joint technology inventories of promising netzero emission technology options for the iron steel and chemical industries two coimplemented demonstrations of promising technologies in china and cocreated scaleup paths and roadmaps of the selected industrial technologies in both regions it will also develop the most uptodate highresolution multisectoral national and regional ghg and shortlived climate pollutant emission inventories as well as dynamic monitoring of key emission sources at high spatiotemporal granularity a stateoftheart modelling framework will be developed exploiting and advancing cuttingedge and established modelling tools for eu and china using the latest emissions data representing technology and policy options enabling assessment of socioeconomic impacts covering multiple economic sectors and regions and offering high spatial and technology detail the enhanced models will be used to coproduce netzero pathways for the eu and china explicitly assessing cobenefits and tradeoffs of climate policies with other societal goals while exploring cooperation policies and governance to drive the global transformation and assessing the distributional and globallevel implications of the two regions decarbonisation the pathways will be documented in new workspaces in the i2am paris platform
the first economically viable process for phosphate recycling

in the eu phosphorus p is listed as a critical raw material it is essential for life and there is no known substitute p is a vital constituent in fertilisers the eus agricultural need is 39 mtyr we import 90 of what we consume and 90 of what we use is irreversibly lost the susphos solution upcycles prich waste like sewage sludge ash ssa or struvite into phosphates iron magnesium salts and silica mixtures our highquality pathogenfree compounds are suitable for formulating fertilisers and phosphatebased flame retardants fr reaction byproducts are finechemicals in their own right making our technology a nearzero waste process currently there is no technology except ours that can upcycle ssa for direct use by fr or fertiliser manufacturers competing solutions for p recycling are costprohibitive they all use water as a solvent which means high energy requirements for solvent evaporation our patented solution uses merely waste heat which allows us to price our phosphates on the same level as if they were derived from mined phosphate rockwe will create an independent eu supply of recycled p reducing the eus dependence on supply and price volatility by 2026 we project revenues of 33m and a 20 displacement of conventionally produced phosphates our circular p will eliminate co2 from rock phosphate transport and reduce pollution caused by mining our urban mines susphos plants will create hundreds of jobs across the eu and at susphos we are striving to strengthen female leadership and inspire women to choose to conduct their higher education and build carriers in chemical engineering and raw materials currently very maledominated sectors with the support of women techeu we aim to upgrade our rollout plan and sharpen our business development skills so that we can grow large enough to become a leading technology provider for circular p and to become and influential player in deeptech innovation ecosystem
machine learning for autonomic system operation in the heterogeneous edgecloud continuum

mlsysops will achieve substantial research contributions in the realm of aibased system adaptation across the cloudedge continuum by introducing advanced methods and tools to enable optimal system management and application deployment mlsysops will design implement and evaluate a complete framework for autonomic endtoend system management across the full cloudedge continuum mlsysops will employ a hierarchical agentbased ai architecture to interface with the underlying resource management and application deploymentorchestration mechanisms of the continuum adaptivity will be achieved through continual ml model learning in conjunction with intelligent retraining concurrently to application execution while openness and extensibility will be supported through explainable ml methods and an api for pluggable ml models flexibleefficient application execution on heterogeneous infrastructures and nodes will be enabled through innovative portable containerbased technology energy efficiency performance low latency efficient resilient and trusted tierless storage crosslayer orchestration including resourceconstrained devices resilience to imperfections of physical networks trust and security are key elements of mlsysops addressed using ml models the framework architecture disassociates management from control and seamlessly interfaces with popular control frameworks for different layers of the continuum the framework will be evaluated using research testbeds as well as two realworld applicationspecific testbeds in the domain of smart cities and smart agriculture which will also be used to collect the systemlevel data necessary to train and validate the ml models while realistic system simulators will be used to conduct scaleout experiments the mlsysops consortium is a balanced blend of academicresearch and industrysme partners bringing together the necessary scientific and technological skills to ensure successful implementation and impact
solving holographic cfts through the synergy of integrability and conformal bootstrap

this proposal will develop innovative methods to access for the first time at non perturbative level the conformal field theory data of the two holographic conformal field theories that provides the bestestablished paradigms of the adscft correspondence n4 supersymmetric yangmills sym and abjm this goal can be obtained combining the techniques of the conformal bootstrap both in its analytical and numerical approaches with integrability such methods proved to be very efficient when applied by themselves and their complementary usage is the main novelty of this project considering that integrability provides a set of conformal data the scaling dimensions the plan is to use this piece of information as an input for the conformal bootstrap to compute the remaining set of data structure constantsa strongly interdisciplinary approach combining analytical and numerical conformal bootstrap together with the most advanced integrability methods will be adopted to overcome the existing difficulties and compute those quantities this will be possible thanks to the critical convergence of the expertise of the two supervising mentors and the researcher on different aspects of bootstrap and integrability a crucial role will be played by novel techniques developed in recent years by the researcher the new methods resulting from this action are expected to have a wide applicability allowing the study of general correlation functions and to lead to quantitative answers to outstanding questions on adscft the training plan is designed to boost significantly the researchers scientific skills as well as his teaching abilities with the delivery of two phd level courses the action involves a strong dissemination and outreach plan including scientific divulgation a public lecture and the creation of a websiterepository hosting permanent openaccess resources for the scientific community which will greatly facilitate further studies of holographic theories
optical 6g cell free networks

the opti6g project develops a photonic near ir cell free 5g network which does not suffer from interference because of the propagation characteristics of em waves in this part of the spectrum and provides universal broadband coverage within buildings from pervasively located owc access pointsthe benefits of applying cell free near ir networks in buildings are 1 multiconnectivity can be configured with cell free network thereby improving link quality and reliability 2 there is no longer the need for building owners to subdivide their nonpublic mobile building network into cellular areas 3 building owners no longer need to request permission from mnos to use their licensed spectrum since the system operates at the optical unlicensed bands 4 interference between inside and outside access is managed by an ai based distributed scheduler 5 position and orientation of end user equipment can be measured very accurately it provides solutions to two main barriers to develop this challenge i brings together a select multidisciplinary team of research institutions and industries in a collaborative project to develop and demonstrate this vision who otherwise would not have assembled to achieve this goal ii develops a proof of concept demonstrator in oledcomm and runel ii performs experiments to measure position and orientation of end user equipment at uvsq and ubruthe starting point is 1 stateoftheart cell free 5g ran solution and very high accuracy sub cm accuracy localisation measurement system developed by runel 2 the state of the art vcsel infrared source and highspeed pin photodiodes receivers and that supports 1 gbps data rates up to 5 m over a field of emission of 25 developed by oledcommthe project brings together these technologies to produce an easy installation and operation license free broadband network for indoor buildings the outcome will be lowcost commercially attractive broadband cellular access within buildings
autoadaptive neuromorphic brain machine interface toward fully embedded neuroprosthetics

nearly 746000 people sustain a spinal cord injury every year with dramatic human societal and economical cost leading to impairment or even complete loss of motor functions motor brainmachine interfaces bmis translate brain neural signals into commands to external effectors bmis raise hopes that limb mobility may be restored providing patients with control over orthoses prostheses or over their own limbs using electrical stimulation in spite of spectacular results taking neuroprosthetics into daily practice has proven difficult currently neuroprosthetics are restricted to assisted trials in laboratories and require regular retraining of a decoder in a supervised manner within controlled environments they include various components recording device antennas base station computers connected to effectors etc that are complicated to install and to use building on the consortiums unique experience in clinical chronic bmis the project will address major methodological and technological breakthroughs to achieve the first assistancefree motor neuroprosthetics system nemo bmi project will conduct the exploration of assistancefree and easy to use portable neuroprosthetics including wireless neuronal activity recorder a realtime neuronal activity decoder based on integrated technologies and a spinal cord stimulator a first objective is the crucial improvement of usability by introducing an autoadaptive framework to train the decoder in an adaptive manner during the neuroprosthetics unsupervised use brainguided spinal cord stimulation activating patients limbs with an automatic stimulus pattern optimization is the second project objective a third objective is the exploration of miniaturized embedded solutions by taking advantage of a novel neuromorphic hardware architecture nemo bmi technologies will be studied offline and online in two ongoing clinical trials and will be critical to specify the nextgeneration assistancefree bmi
decoding the rules of enhancer promoter specificity throughout development

enhancers control spatiotemporal gene expression which is central to the diversification of celltypes and tissue differentiation enhancers can be located in close proximity to or distally from their target genes promoters including in introns of noncognate genes to regulate gene expression distal enhancers e must come into proximity to interact with their promoters p through foldinglooping of the intervening dna how enhancers identify and regulate their specific target gene remains poorly understood and is subject of this proposal chromosome conformation capture based techniques such as nucleartitrated nuti capturec are powerful tools for the genomewide investigation of enhancerpromoter proximityinteractions epis at subkilobase resolution this project aims to uncover general features of epis by measuring and characterizing epis using nuti capturec across many different developmental stages and tissues during drosophila embryogenesis i will analyze a massive capturec dataset already generated by host lab capturing interactions from 16663 genes promoters each at eight different conditions with four replicates thereby providing unprecedented scale and resolution i will integrate this capturec resource with multiple genomewide datasets gene expression histone marks and chromatin accessibility from the host lab and others the analysis of this comprehensive epis atlas will link enhancers to promoters genomewide characterize features driving ep specificity and potentially identify novel factors involved in their establishment this new view of tissue and developmental stage specific epis will serve as a unique resource that we will share through a userfriendly webbased portal to a large community using this important model organism the biological insights that we uncover including features linked to ep specificity and tissuesspecific regulation will interest a very broad community studying genome regulation
development of newtonature reactions under the concept of synergistic catalysis through the design of novel cobaltbased artificial metalloenzymes

artificial metalloenzymes arms that is designed enzymes containing a synthetic metal cofactor within a protein framework locates itself as a promising area of research for the discovery and development of new transformations we set our attention in cobalt complexes as cofactors a firstrow earthabundant and nontoxic metal that is currently underexplored in arms cobalt complexes present a highly versatile chemistry including they ability to participate in allylic functionalization reactions an important transformation for the pharmaceutical industry as can deliver structural frameworks that are widely spread in biological active compounds allylic functionalization reactions are underdeveloped in biocatalysis and the expansion of important homogeneous reactions as the before mentioned into the realm of enzymes is an absolute necessity for the development of sustainable chemistry coarms cobaltcontaining artificial metalloenzymes proposal aims to create new generations of arms relying on the unique reactivity of synthetic cobalt complexes in allylic substitution reactions an unknown reaction in enzyme catalysis and an underexplored metal for the discovery of newtonature reactions the proposal balance between host expertise dr gerard roelfes in bioinorganic and chemical biology and the researchers skills dr franco dellafelice in synthetic organic chemistry the result is a cooperative field where two different branches converge with the aim to develop new concepts and environmentally compatible tools in chemistry to access organic frameworks of high significance to the pharmaceutical and agrochemical industries
fuel cell propulsion system for aircraft megawatt engines

green hydrogen as a fuel offers the possibility to significantly reduce or even eliminate all of aircrafts greenhouse gas emissions when liquid hydrogen lh2 is used in fuel cells fc for power generation this results in no co2 no sox and no nox emissions the best way to achieve this solution is to develop a hydrogen propulsive fc system as an integral part of a new lh2 aircraft concept this means moving away from the current plug and play separate motor development and aircraft architecture philosophy towards a disruptive integrated way of development which requires a cocreation approach of the propulsion system and the aircraft fame follows this approach by collaborative research and development between on one hand partners involved in development of the needed systems of the fuel cell and on the other hand airbus as and aircraft designer manfacturer und integrator thereby it is ensured that on all levels from material over component and subsystem up to propulsion system on aircraft level an optimization is realized the focus of fame is on developing a complete compact highefficiency full electric propulsion system based on lh2 as energy source for short to medium range smr aircraft fame will develop all the subsystems which are needed and integrate these in a mw fc propulsion system ground demonstrator with the vision to scale it up to aircraft level sufficient for smr aircraft fame shows the feasibility of a multimw fc propulsion system for hydrogenpowered smr aircraft the system will provide the basis for clean aviation in phase 2 to undergo a system flight test
biomimetic sensorized barriersonachip unveiling a new generation of marketready investigation tools

the lack of reliable in vitro preclinical models represents a critical aspect unanimously recognized by the scientific community as detrimental in the pathway of bringing new medications from the laboratory to the bedside addressing this issue would provide immense benefits to drug discovery and development processes by ethically limiting animal testing and drastically reducing costly failures in clinical trials to date most in vitro models fail at recapitulating the physiological microenvironment and this often results in misleading data withdrawal starting from my prototype of real scale dynamic and biomimetic bloodbrain barrier model in this project i aim at the validation of my system after an upgrade step consisting in embedding sensing features in the platform thus allowing a realtime evaluation of barrier formation and integrity maintenance characterized by microcapillary sizefenestrations and fluid flows similar to the in vivo physiological barrier my tool will represent a drastic innovation over other wellestablished models in the literature and available on the market allowing a reliable reproduction of the physiological environment and an accurate estimation of the amount of drug andor nanomaterial concentration delivered through the barrier validation will be performed in relevant conditions by implementing stroke and brain cancer models all artificial components will be fabricated through twophoton polymerization 2pp a disruptive mesoscale lithography technique that allows the fast fabrication of lowcost structures with resolution up to the nanometer scale as well as great levels of scaffold reproducibilityaccuracy the proposed platform can be easily adopted in research laboratories and pharmaceutical industries as an advanced preclinical model the primary biomedical applications of which consist in reliable screenings of drugs against pathologies of the central nervous system