Dragon09/odtu_chatbot huggingface dataset:
public health in transition health care at the dawn of the habsburg empire 19181924

this project will investigate the transition of the public health system of the multinational habsburg empire in successor national states during and after the empires collapse at the end of wwi the projects aim is to analyse how health institutions dealt with epidemic diseases and mental illnesses resulting from the war and geopolitical upheavals which reshaped the sense of self and created identity disorientation as a case study it will focus on the macroarea between the former imperial capital city vienna the main slovenian urban centre ljubljana and the main habsburg portcity trieste the fragmentation of this common space will be observed by comparing three models of transition of the common habsburg public healthcare system in the three corresponding successor national states the austrian republic the kingdom of serbs croats and slovenes abbreviated to shskingdom and the italian kingdom three models of adapting strategies will be examined simultaneously from a regional a national and an international perspective the research spans from the summer of 1918 until the middle of 1924 that is from the establishment of national councils in the different regions of the collapsing monarchy until the final diplomatic adjustments between italy and the shskingdom with the treaty of rome which brought to an end the international crisis concerning the free city of fiumerijeka and established the geopolitical shape of the whole northeastern adriatic area the project will be developed with the faculty of arts at the university of ljubljana
soil multifunctionality from biodiversity associations to understanding mechanisms

humanity places large demands on its cultivable soils for specific functions eg food production at the expense of the capacity of soils to provide multiple functions carbon storage biodiversity however currently multifunctionality is studied without considering the mechanistic linkages among individual soil functions all soil functions depend on three key resources energy nutrients and water producing critical tradeoffs and synergies among functions furthermore we lack a common measurement framework to assess soil multifunctionality i propose to address these two challenges by 1 developing a soil multifunctionality assay that combines existing measurement techniques with latent variable models and 2 causal modelling to test how different soil functions interlink across different soil types i will sample grasslands across intensiveextensive land use gradients that are representative of nw european edaphic and management conditions as my study system i will use latent variable models conditioned on multiple indicators per soil function to develop a standardized testing procedure measuring five key soil functions plant production nutrient cycling carbon and water storage and habitat provision next i will combine this standardized procedure with structuralcausal modelling to test the role of resource division during plantmicrobesoil interactions in determining which functions predominate my mscaproject will elucidate the mechanisms underlying tradeoffs and synergies among soil functions and reveal how differences among soils drive differences in soil multifunctionality
bioactive lipids regulate adaptive immune responses in neurodegeneration novel target for treatment

traditionally ad is regarded as a neurodegenerative disease and as such the major focus has been on investigating and treating neurodegeneration and neuronal functioning only the last decade it became apparent that ad pathogenesis strongly interferes with immunological processes and vice versa indeed my novel findings show that the immune system in patients with early ad is already severely derailed and highlight a specific role for cd8 tcells my exciting data also suggest the importance of bioactive lipids like sphingolipids and specialized proresolving mediators in early ad pathogenesis possibly by controlling the immune system the identification of how the altered lipid landscape underlies ad and affects immune homeostasis is essential to come to new insights into disease pathogenesis and to discover novel intervention strategies the ultimate goal of the brain project i therefore here hypothesize that a misbalance in bioactive lipids plays a key role in the induction and propagation of the impaired immune homeostasis associated with ad progression thereby forming a novel target for treatment my key objectives arei unravel bioactive lipid signatures and define correlations with disease progression sex biomarkers and an unbalanced immune response in early ad ii elucidate the underlying mechanisms of uncontrolled lipid mediator balance and how this relates to the altered immune landscape iii identify key players in this process and perform proof of concept studies to define if restoring the lipid balance reinstates immune homeostasis and consequently cognition and disease pathogenesis in adtogether this study will provide indepth understanding of how bioactive lipids affect immune mediated processes that underlie disease progression investigate interaction thereof and decode underlying mechanisms to pave the way towards the development of improved prognosticdiagnostic tools and identification of novel therapeutic targets
physics of the first mammalian epithelium

epithelia operate major biological functions throughout the human body forming de novo during preimplantation development the trophectoderm te is our first epithelium the te mediates the formation of the first mammalian lumen which involves considerable physical challenges indeed pressurized fluid pumped through the te fractures intercellular contacts before cells squeeze this fluid into a single lumen we recently found that cell adhesion and cell contractility determine the position of this lumen which then controls further differentiation of the te this suggests that physical cues can determine the first mammalian axis of symmetry and te patterning however most physical properties of epithelia controlling this process remain unknown as their study in vivo has been so far very limited in this project we will investigate how the physics of the te shapes and patterns the mouse preimplantation embryo by using novel approaches such as microfluidics and optical tweezers that allow direct measurement of physical properties in vivo first we will determine epithelial transport properties of the te and their regulation during lumen opening we will next map plasma membrane reservoirs and membrane mechanics during preimplantation development we will then characterize how the nuclear envelope and chromatin regulate nuclear mechanics during epithelial thinning with this broad and unprecedented in vivo physical characterization we will determine how epithelial transport plasma membrane and nuclear mechanics influence epithelial stretching and patterning during lumen growth and positioning finally we will determine the relative contributions of these physical properties in this process and investigate their relationship together we will build an integrated view of how uncharted physical properties of epithelia control stretching and patterning in the context of a process that is key to the fertility of the ageing european population
demonstrating energy intensive industryintegrated solutions to produce liquid renewable energy carriers from captured carbon emissions

ghg emissions reduction policies to mitigate climate change heavily impact on energy intensive industries leading to loss of employment and competitiveness in addition variable renewable generation faces high risks from electricity curtailment if renewable surplus is not used carbon capture and utilisation technologies that make use of industrial flue gas and renewable surplus will play a key role in the clean energy transition of industry various technologies exist but most are still quite demanding in terms of materials and energy being costly and inefficient captus key objective is to demonstrate sustainable costeffective and scalable pathways to produce highadded value energy carriers by valorising industrial carbon emissions and integrating renewable electricity surplus to this end 3 complete value chains will be demonstrated at 3 different demosites i bioprocess based on a twostage fermentation to produce triglycerides in a steel plant ii lipidsrich microalgae cultivation followed by hydrothermal liquefaction to produce biooils in a chemical plant and iii electrochemical reduction of co2 to produce formic acid in a cement plant the proposed technologies will be tested at trl7 and the obtained energy carriers will be validated by upgrading studies captus will also validate solutions regarding economic environmental societal and geopolitical criteria contributing to the development of novel business models guidelines and strategies captus has been structured in 8 wp combining rd activities project management and demonstration activities captus addresses this complex challenge by gathering a competitive consortium of 18 partners from 8 eu countries overall captus innovations at technical economical managerial and social level will enable the consolidation of ccu technologies within 3 eii key sectors and leverage their benefits by reducing carbon emissions increasing renewables share and producing valuable energy carriers
sensing endometriosis on portable auxiliary devices

sensopad initiative heralds a transformative era in womens health by addressing the longstanding challenges posed by endometriosis ed eds early detection is often underdiagnosed due to its asymptomatic nature pivotal for improved health outcomes and reduced healthcare costs sensopad introduces two pioneering ed sensing systems sensopad seamlessly integrated into sanitary pads and sensomfgfet a portable pointofcare poc devicesensopad comprises three biological processing units bpu bpu1 bpu2 and bpu3 ensuring continuous monitoring bpu1 combines an electrochemical sensor with rfid while bpu2 merges a chemicalbased fuel cell with an electrochromic cell bpu3 an energetically autonomous unit synergizes bpu1 and bpu2 capabilities for seamless monitoring sensomfgfet a poc device utilizes microfluidic systems and bioconjugated gfet with rfid functionality capturing specific dna snps from the menstrual fluid as early ed indicators both devices are complemented by a userfriendly mobile application enabling realtime data acquisition and analysis an advanced cloud platform integrated with ai enhances diagnostic accuracy this innovative approach shifts the paradigm in ed detection empowering women clinicians and healthcare systems sensopad detects biomarkers providing insights during menstrual cycles if concerns arise during its use users transition to sensomfgfet at clinical points combining athome convenience with clinical precision sensopad aims to reduce ed diagnosis time from eight years to days enabling early treatment preventing symptom deterioration optimizing infertility care and streamlining healthcare journeys integrating sensopads with a mobile app and aienriched cloud platform ensures accurate costeffective diagnostics detecting silent instances of ed and signifies a paradigm shift fostering informed proactive and inclusive healthcare decisions for women worldwide
tracing the origin of clonal pathogenesis

epithelial cancers are thought to evolve through a competitive process of mutation and selection in which the serial acquisition of oncogenic mutations confers an increasing fitness advantage culminating in neoplastic transformation tumour invasion and metastasis this programme often initiates through a phase of field cancerization in which mutant clones expand within the context of physiologically normallooking tissue to mitigate the risks associated with field cancerization protection strategies have evolved that resist mutant clone expansion from the development of anatomical features that limit clone growth to the activation of genetic and immunological surveillance mechanisms yet despite these insights our knowledge of how oncogenes act alone or in combination to evade these protection mechanisms to drive clonal pathogenesis remains largely unknown here by combining a unique genetic lineage tracing strategy with comparative singlecell genomics and quantitative modellingbased methods we will define the mechanisms that mediate mutant clone competition by placing an emphasis on the squamous and columnar epithelia of the gi tract we will investigate whether and how injury and inflammatory cues as well as ageing enable tumorigenic clones to evade natural protection strategies functioning as a second hit in driving field cancerization and neoplastic transformation finally to explore the translational relevance of our findings we will combine dna sequencing singlecell methods and spatial transcriptomics with the design and genetic manipulation of stateoftheart 3d organ cultures to investigate mutant clone dynamics in human tissue by tracing the origins of clonal pathogenesis these findings promise insights into the design of new prevention detection and treatment strategies targeting the early stages of cancer progression
the nimble system a novel noninvasive and nonionizing medical device for the continous monitoring of patients with implanted cardiovascular stents

at nimble diagnostics we are developing a firstinclass microwavebased medical device for the noninvasive and nonionizing monitoring of patients with implanted stentsstents are one of the most implanted devices worldwide and are used to reopen blocked arteries and restore the correct flow of blood or other fluids they are especially useful to prevent heart attacks or to treat their lasting symptoms but after implantation become blocked or damaged in 30 of cases symptoms only appear after a stent is already 90 dysfunctional which increases the incidence of serious complications including strokes heart attacks or sudden death diagnosis of malfunctioning stents is still symptomdriven and is based on an invasive procedure called catheter angiography involving anesthesia xray exposure and 24h hospitalization recovery this complex costly and invasive procedure is not appropriate for ongoing monitoring which is why the standard of care only reacts when patients already have potentially lifethreatening symptomsthe nimble system can read the electromagnetic signature of any stent noninvasively in less than 5 seconds and can be used to provide information on stent status and malfunction during regular clinical visits thus nimble enables early treatments to prevent negative outcomes and personalization of therapy shifting from reactive to proactive careour technology is currently at trl56 with an mvp that has shown excellent results in preclinical validations we have also started the firstinhuman testing in a pilot study of 30 patients that will finish early 2024the eic accelerator program will allow us to bridge the biggest risk of our project by performing the regulatory clinical trial to obtain the ce mark as well as support us to create and access a multibillion blue ocean market opportunity this will allow us to establish nimble as a european leader in the future of implant diagnostics and aid millions of patients worldwide
supporting european coastal regions in their transition to a sustainable blue bioeconomy

the blue bioeconomy defined as the production and conversion of renewable marine biological resources into value added products such as food feed biobased products and bioenergy entails a large set of opportunities for european coastal communities innovative business models based on circularity shortchains digital solutions and ecosystem contributions offer the chance to stabilize and create new enterprises and jobs also for the lowereducated while transforming remote rural areas also into interesting revitalized climatefriendly places to live however blue bioeconomy actors struggle with challenges related to technology lack of knowledge skills or regulatory barriers bluebioclusters brings together 12 support organizations from across europe all of them highly engaged in their 9 regions in assisting startups companies and policy makers to make best use of innovations they have joined forces to improve develop and implement new support tools and methods based on systematic collection benchmarking and joint knowledge creation on blue biobased value chains practice cases and incentives wp2 ecosystem service valorization wp3 technology needs identification and transfer of solutions wp4 startupssmes experts and support mechanisms coaching cocreation wp5 as well as communities of practices to foster longterm stakeholder cooperation within and across the regions wp6 while we expect to create longlasting impact already within the project lifetime by engaging with hundreds of actors within our regions to stimulate collaboration and actions for change activities are designed to be continued postproject being also open for other blue regions clusters and individual companies to join to that end the interactive bluebiocluster platform will not only serve as a repository of the projects outputs in terms of stakeholders and services but is set up in such way that it will be continuously updated and maintained by and with its users also postproject
sustainable soil management decision support system in viticulture

soil erosion and degradation pose significant threats to agricultural sustainability food security and economic stability despite awareness conservation measures are often neglected due to barriers such as cost and information gaps addressing these challenges requires multidisciplinary approaches integrating scientific research stakeholder engagement and technological innovation the project aims to develop comprehensive soil erosion models understand stakeholders perceptions and create a decision support system dss for vineyard management the objectives include developing innovative solutions enhancing soil health mitigating erosion risk understanding social factors and promoting sustainable practices the project emphasizes multidisciplinary integration and knowledge transfer leveraging advances in artificial intelligence big data analytics and cloud computing to address the impacts of climate change and promote agricultural ecosystem conservationthe proposal will be developed by 9 partners from 4 european countries with 5 academic organizations and 4 smes with different backgrounds
enabling trustworthy european data spaces through selfsovereign identity and privacy preserving technologies

datadriven innovation will bring enormous benefits for citizens affecting all sectors of activity and the daily lives of all europeans it will enable for example aidriven services to find causes for diseases or share attributes of individuals identity to quickly participate for instance in social or education activities across europe however identity compromises leakages or abuses of this kind of data pose serious threats that may compromise the proliferation of data spaces involving personal data and reduce the opportunities offered by the data economy the goal of the trusted project is to design and develop a robust selfsovereign identity management method with advanced features as well as a set of combined privacy enhancing technologies pets to enable two highly scalable and reliable services on personal data within data spaces with privacy guarantees that exceed the requirements of the gdpr eidasv2 and eudi wallet 1 a trustworthy federated learning service combined with several pets that will allow aipowered studies of siloed datasets with privacy guarantees2 a scalable and reliable self sovereign identity management service combined with methods for aibased document validation multimodal biometrics and zkpbased selective disclosure techniques that will enable electronic attestation revocation of credentials and sharing of specific attributes of identity in a privacy preserving waythe components will be piloted demonstrated and validated in a minimum viable data space that follows the implementations and deployments defined under the edc framework which is powered by the specifications of the gaiax aisbl trust framework and the idsa data space protocolthe consortium is composed of 10 interdisciplinary partners 2 research organizations 3 smes 2 large entities 2 ngos and 1 clinical partner with extensive experience and expertise to guarantee the correct performance of the activities and the achievement of the results
understanding the demography and stratification of singlehood in europe

amid declining marriage and fertility rates singlehood is rapidly gaining scholarly attention yet singlehood scholarship is remarkably fragmented and underdeveloped existing theories are divided between narratives of singlehood as an unfavorable outcome or an empowering life choice moreover existing frameworks are limited by a glaring inconsistency in the measurement of singlehood an overwhelming focus on young adults and a general neglect of crossnational and intersectional approaches these limitations undermine our ability to establish a comprehensive holistic framework that answers fundamental questions 1 what the scope of singlehood is in the adult population and 2 how social stratification is reproduced within the single populationsingle proposes to resolve these tensions by taking an unprecedented comprehensive comparative approach that bridges demographic and sociological debates and pays attention to the diverse challenges and opportunities that single life offers first single takes a population approach by establishing a demography of singlehood framework that will produce and disseminate estimates of the prevalence composition and duration of singlehood across europe using various largescale secondary data sources through novel data collection single will also offer pioneering insights into singles selfidentification and motivation to be single to improve our understanding of selection and terminology in singlehood research second single takes a stratification approach to expand our understanding of social inequality within the single population single will disentangle how demographic economic and cultural forces systematically shape singles unequal outcomes within and across countries by documenting singles time use wellbeing perceived pressure to partner and access to support systems single will reframe our knowledge of the complexity and diversity of european singlehood