Dragon09/odtu_chatbot huggingface dataset:
fostering a european research area for health research

excellent eu programs push health ri but are not sufficient synergy with strategic initiatives in ms and a new model for impactful collaborations are needed to address the challenges for health era4health brings the opportunity to increase eu transnational collaborative research funding by creating a funding body for joint programming in priority areas addressing eu public health needs with total duration of 7 yearsera4health focuses on tackling diseases and reducing disease burden and the following challenges 1 the increasing demand for a better quality of life and a better care of patients 2 the need to transform public health care systems in more effective efficient equitable accessible and resilient ones and 3 the need to strengthen disease prevention and health promotion in this view era4health objectives are so1 support relevant medical research including clinical fields and intervention areas prevention diagnosis treatment so2 improve the utilisation of existing health technologies in clinical practice so3 build capacity in particular in conducting investigator initiated clinical studies at eu scaleso4 implement and advance the practice of rri across the breadth of the programmeera4heatlth will be implemented in 2 phases phase 1 2 years will implement joint calls focused on nutrition and lifestylerelated diseases cardiovascular diseases and nanomedicine 4 in two years in parallel it will establish a supporting framework to overcome the challenges in launching international iicss joint calls phase 2 if the ec approves it additional multinational calls for iicss and joint calls for other priority areas will be launched in accordance with the decision of the health programme committee taken at the end of previous phase34 partners 20 from eu 3 third countries associated to he and 2 nonassociated non eu will commit 90510000 during the 3 first years as financial support to third parties
potential nutrient release from deglaciating land surfaces to downstream ecosystems pulse

glacier retreat is escalating in response to amplified arctic warming this exposes large areas of new glacier forefield to seasonal freezethaw wettingdrying cycles and variable oxygen conditions these physical changes dramatically alter biogeochemical cycling in previously glaciated sediments facilitating soil and vegetation development in the 21st century arctic streams are wellknown suppliers of the key nutrient nitrogen n to nlimited fjords and coasts which host lucrative fisheries however the influence of glacial retreat and associated soil development on n release to streams thus fjords and coasts is a complete unknown the pulse project aims to quantify the impact of arctic glacier forefield exposure on soil n cycling and export to coastal marine environments and how they are influenced by time since deglaciation local geology and freezethaw cycling in pulse i will measure n release from a field scale chronosequence in a subarctic glaciated catchment and quantify the forefield soil n contribution to river n runoff i further use a space for time approach to simulate future climate conditions for high arctic forefield sediments thus predicting future high arctic forefield n release this highly interdisciplinary project combines my background in soil biogeochemistry with glacier hydrochemistry at the arctic university of troms uit uit is the ideal host for me to gain new analytical chemistry and modelling skills in order to establish how future glacier retreat will shift sources of riverine n transport to downstream fjords and coasts a secondment to the norwegian polar institute will additionally expand my scientific expertise and network to include marine monitoring stakeholders directly using my results pulse will therefore provide a highimpact first quantification of future potential proglacial soil n leaching across subarctic to high arctic climates which will inform future ecosystem management policies in the arctic
exact and approximate computation of tensors and polynomials

this research proposal will address fundamental problems concerning the complexity of computingand manipulating polynomials for example consider the following questions1 what is the complexity of computing the total weight of perfect matchings of a weighted graph2 is there an efficient deterministic parallel algorithm that determines whether a graph has a perfect matching3 is approximation much easier than exact computation4 how many epr pairs can we distill from a given quantum statethese seemingly unrelated questions represent some of the most important and challenging open problems in theoretical computer science the first is the algebraic analog of the famous p vs np problem the second question amounts to asking whether a symbolic matrix associated with the graph has full rank parallel randomized algorithms for computing this rank are known but not deterministic ones this is an instance of the polynomial identity testing pit problem the most fundamental algebraic derandomization problem the third question asks about the relation between a complexity class and its closure which lies at the heart of the geometric complexity theory gct program the last question concerns the subrank of a tensor representing the given quantum state problems related to rank of tensors are at the heart of both algebraic complexity and quantum information theoryrecent years have seen tremendous advance in our understanding of algebraic computations with new lower bounds new pit algorithms and with increasing connections to other branches of computer science and mathematics discovered results proved by the pi play an important role in all of these advancesthis project aims to study these and related problems and to develop new methods for solving them making progress on any of these problems will constitute a significant breakthrough
automated inspection robots for surface aerial and underwater substructures

aerosub will develop worldclass robotic solutions for different wind energy operating scenarios fixed and floating offshore wind farms promoting innovations for operation and maintenance om procedures to foster the competitiveness and sustainability of renewable energy production in challenging environments aerosub will demonstrate the added value of robotics deeply integrated with advanced ai and data analytics technologies and their potential of reducing the eco2 emissions of om operations by up to 15m tonnes enabling cost savings by 2400mwyear and lowering the levelized cost of electricity lcoe of offshore wind energy by 25 by deploying an orchestration of multiple robotic platforms including uncrewed fleet carrier ufc unmanned surface vehicle usv remotely operated vehicles rovs long endurance aerial drones uas and unmanned aerial vehicles uavs and optimizing humanrobot and robotrobot collaboration aerosub aims to reduce the onsite humans exposure to dangerous and strenuous environments large scale pilots related to monitoring inspection cleaning and maintenance of structures below and above water line will be performed autonomously by aerosub solutions which requires introducing aibased features for enhancing perception and onplatform decisionmaking capabilities improving collaborative navigation manipulation and mission planning aerosub is proposing the first fully unmanned robotic solution for both aerial and underwater inspection and intervention demonstrated in real offshore wind farm to show an increased om operational efficiency of 40 reducing of the associated downtime by 60 as well as the risk exposure of workers by 90 digital twin dt and ai solutions for automated information analysis of operational data collected by remote robotic platforms in 30 operations will increase the reactivity responsiveness and intelligibility of the om operations reducing the human burden by 80 to monitor
exploring perineural invasion pni mechanisms in pancreatic cancer using hyperpolarized 13c nmr

pancreatic ductal adenocarcinoma pdac is a devastating disease with 5year survival rate of less than 7 existing treatments are limited because 90100 of patients develop perineural invasion pni pni is associated with severe pain poor prognosis poor survival and tumor recurrence and involves nerve invasion by cancer cells as a result of dynamic interactions between them and other cells in the tumor microenvironment tme schwann cells scs are part of this tme and are activated by cancer cells to become pni promoters to date the question of how metabolic dysregulation generated by cancer cells characterized by different levels of lactate and an acidic tme drives scsmediatedpni remains unanswered taking account that pni is still poorly understood and that there are no pnitargeted diagnosis methods or effective therapies this project pursues the study of the role of metabolic alterations induced by pdac cells on scs and how that drives scs activation and pni to achieve this goal nuclear magnetic resonance nmr mediated hyperpolarization of metabolites as contrast agents that could be used later in clinical diagnosis without adverse effects will be used hyperpolarization by parahydrogeninducedpolarization phip boosts the detectable nmr and magnetic resonance image mri metabolites signals by a factor of 10000 it allows obtaining precise kinetic data on metabolites interconversion on short timescales and the insights from cells can be directly translated into in vivo studies all of this represents an advantage over standard biological studies which often struggle to capture these types of events using nmrphip technology with cellular and molecular biologybased techniques on scspdac cells cocultures and on an in vivo pni model this project will contribute to identifying new predictive biomarkers for future monitoring and early diagnosis of pni as well as to the potential development of pnitargeted therapies
a sense of direction cooperative behaviour and chemotaxis in the life cycle of trypanosoma brucei

many protozoan parasites have complex life cycles requiring migration through different organs in their hosts the current mindset is that parasites act as individuals and that tissue specificity is largely dictated by receptorligand interactions between pathogen and host surface molecules however parasites are more autonomous and manipulative than we give them credit for i propose that selfsteering a mechanism by which groups of cells migrate in response to gradients that they create andor modify is central to their ability to orient themselves and home into host tissuestrypanosoma brucei which causes sleeping sickness cycles between mammals and tsetse flies trypanosomes lack gprotein coupled receptors gpcr and heterotrimeric g proteins which act as sensors and signal transducers in yeast and multicellular eukaryotes but encode a large number of receptor adenylate cyclases we recently discovered that trypanosomes generate ph gradients on semisolid surfaces and use cyclic amp camp signalling to move collectively in response to them this correlates with their ability to cross barriers and sequentially colonise organs in tsetse flies our newest findings that trypanosomes respond chemotactically to other metabolites together with evidence from several laboratories that t brucei is not restricted to the blood and central nervous system in mammals but also invades other organs are the focus of this projectmy objectives are to elucidate the intracellular mechanism of campmediated ph sensing to explore other cues for chemotaxis and determine how signals are transduced to establish whether the expanded family of adenylate cyclase genes in t brucei plays a role in extravasation and colonisation of different organs in mammalian hoststhis is the first comprehensive analysis of the mechanisms governing directed migration by a parasite and is a paradigm for new forms of sensing in eukaryotes lacking gpcr
tracking the evolution and dynamics of intermediatemass black holes to forecast their upcoming observations

in the next few years electromagnetic and gravitationalwave facilities will uncover the elusive population of intermediatemass black holes imbhs the likely progenitors of presentday supermassive black holes the upcoming detections promise to revolutionise our understanding of the blackhole population across the cosmic epochs in preparation for this exciting future it is now fundamental to shed light on the debated dynamical processes governing the growth of imbhs tesifa is the longawaited program that will clarify the timespan black holes spend in the intermediatemass range thus allowing for a solid interpretation of the upcoming imbh detections leveraging the emergent picture according to which imbhs primarily grow via stellar accretion tesifa will numerically model the rates of tidal disruption events tdes thousands of which will be detected by the vera rubin observatory starting next year and gravitationalwaveinduced extreme mass ratio inspirals emris accessible to the planned lisa mission about imbhs by combining this approach with stateoftheart observations of nearby stellar systems tesifa will place novel constraints on the local imbh population furthermore tesifa will investigate the ratio between tde and emri rates as a function of the host galaxy properties so that the observed tde rates could be used to forecast lisa emri rates overall tesifa will lay the foundation for understanding the imbh demographics and best exploiting their upcoming observationsat princeton university the fellow will work alongside worldleading experts in the field of imbh observations she will learn the challenges affecting the observations of imbhs and their hosts as well as the capabilities and limits of electromagnetic facilities the planned training will perfectly complement the fellows extensive numerical expertise making her a well rounded scientist and placing her at the forefront of the research targeting imbhs
hierarchical metalorganic frameworkcovalent organic framework mofcof on carbon nanofibers for electrocatalytic co2 conversion

electrocatalytic co2 reduction ecr reaction offers a powerful strategy to enable a circular economy that converts co2 from a waste to a useful resource among the possible catalysts for the ecr metalorganic frameworks mofs offer a tunable porous structure for rapid mass transport and easy access to a high density of catalytic sites which can be tailored at the molecular level leading to superior activity moreover copperbased mofs cumofs show relatively low cost and ability to form c2 products however the low selectivity poor stability and electrical conductivity set obstacles for ecr applications of these materials the enliven project aims to surpass these limits through the combination of cumofs with highly stable and conductive covalent organic frameworks cofs forming coreshell mofcof thin films on mesoporous conductive carbon nanofibers cnfs to this aim cnfs prepared by electrospinning will be covered by a homogenous metal oxide layer and then pyrolysed to produce metal seeds for the solvothermal growth of homogeneous crystalline cumofnh2 layers then the nh2 functionalized surface will be modified with aldehyde groups necessary for the growth of a cof layer to allow tuning the selectivity towards the ecr and decreasing the competing hydrogen evolution reaction superaerophilic electrodes will be assembled using cof ligands with hydrophobic groups and designing a special morphology also enliven will study the new confined chemistry that takes place inside the pores of mofcof architectures rationally designed from the molecular through nano to mesoscale this knowledge will provide the blueprints for the development of more durable and efficient electrocatalytic materials the project will be conducted in unipd and dtu secondment the fellow sannajafabadi with expertise in mofcof synthesis will acquire new skills in the synthesis and characterisation of advanced structures for electrochemical applications
molecular characterization of insecticide resistance and transmission competence in sand flies major vectors of leismaniasis

leishmania transmitted by sand flies comes second only to malaria in terms of parasitic causative fatalities globally tunisia as well as the mediterranean region are endemic for the disease reporting hundreds of cases annually in the absence of human vaccines controlling the population size of sand flies using insecticides is a key component of leishmaniasis control efforts nevertheless the reliance on insecticides has triggered the selection of resistance which is threatening the efficacy of sand fly vector control programs the molecular aetiology behind the insecticide resistance status of sand flies unlike other insect vectors remains largely unknown the aim of levec is to unravel the mechanisms that underpin resistance to pyrethroid insecticides in sand fly populations collected in tunisia i will use comparative transcriptomic analysis to identify genes differentially expressed in resistant individuals and functionally validate their role using state of the art in vitro biochemical assays and in vivo transgenesis and crispr genome editing approaches the outcomes will substantially improve our ability to track the phenomenon of sand fly resistance in the field and design mitigation strategies furthermore levec aims to identify genes that determine the ability of sand flies to transmit the leishmania parasites for that i will focus on the sand flys midgut the site where the complete development of the leishmania parasites takes place and perform comparative expression analysis using a unique collection of 12 sand fly species with different degrees of vector competence silencing of candidate genes followed by experimental infections will allow me to validate their role in leishmania transmission the outcomes of this analysis will help the design of novel leishmania control tools based on disrupting the adherence andor development of parasites within the sand fly vector
capacitybuilding and transnational cooperation for national contact points ncps for the eic under horizon europe

access2eic is a 7 year coordination and support action which builds upon the foundations laid by previous eic support networks and in line with the new horizon europe framework programme access2eic aims to empower national contact points that have been nominated under the new horizon europe european innovation council and european innovation ecosystems and facilitate cooperation amongst ncps to provide enhanced service across europe specifically the proposed network aims to1improve professionalisation and skills of ncps across europe which in turn will help to simplify access to horizon europe calls lowering the entry barriers for newcomers and raise the average quality of proposals submitted particularly for women entrepreneurs and in widening countries2identify and share good practices promote transnational cooperation and raise the general standard of support to programme applicants taking into consideration the novelties under horizon europe the third pillar and the various stakeholders within the eiceie
advanced nanomaterials to target genomic and zdna for bacterial biofilm eradication

bacteradix aims to develop the firstinclass advanced antimicrobial nanomaterial to target biofilm zdna and genomic dna to eradicate biofilm and resolve chronicrecalcitrant infections infective diseases and antimicrobial resistance are a threat to global health and development biofilm formation is a major cause of treatment failure infection recurrence and acquired resistance development who has declared antimicrobial resistance one of the top 10 global public health threats facing humanity infective diseases are an increasingly dramatic problem because the development of new antimicrobials is being slowed down dramatically and drugresistant bacteria are growing bacteradix addresses this urgent global threat by leveraging breakthrough discoveries and advanced lipidbased nanocarrier technologies to target zdna to destabilize the biofilm and to cleave bacterial genomic dna to kill bacteria the project seeks to overcome the challenges posed by bacteria in biofilms and the slow pace of development of new antimicrobial strategies bacteradix aims at developing a modular and tunable antimicrobial nanoplatform by focusing on two who priority bacterial strains methicillinresistant s aureus mrsa and multidrug resistant p aeruginosa our specific goals include 1 characterization of structural zdna in biofilms 2 design of zdna targeting pnas for 3 lipid nanoparticles decoration to target and destabilize the biofilm 4 design and develop antimicrobial antigene pnas able to cleave genomic dna and block bacterial replication leading to bacterial death and 5 validation of tailorable advanced nanomaterial for biofilm eradication functionality and biocompatibility the longterm vision of bacteradix project is to develop the firstinclass modular nanoplatfom for the tailored design of advanced antimicrobial nanomaterials that can ensure a longterm solution for the treatment of chronic and recalcitrant infections
coordination of national research programmes in agrifood and biotechnology joining forces of eranet cofunds ejp and self sustained initiatives

the green erahub geh represents 15 currently active eu eranet cofunds and selfsustained initiatives in the field of agrifood and biotechnology together with already ended predecessor initiatives they represent 29 coordination actions in which more than 1100 mio euro funding has been mobilised via 89 transnational calls the eranet scheme is a success model for transnational cooperation of national research programmes the partners consider geh an ideal measure to continue and extend this fruitful cooperation the aims of geh are to continue to build on previous achievements and further enhance crosssector collaborations between agrifood and biotechnology eranets through joint transnational funding of collaborative research projects valorise and implement joint activities supporting the market regulatory or societal uptake of results after the end of individual eranets identify common research and innovation priorities agreed upon by the participating national programmes and address them via new joint calls preserve best practice and managerial competences contribute to the planning and complement the implementation of the new heu partnerships and missions broaden the actions and impact of initiatives towards stakeholders and in terms of geographical coverage contribute to achieve the strategic goals of the sdgs in particular zero hunger industry innovation and infrastructure responsible consumption and production life on land partnership for the goals the farm2fork strategy and eus green dealgeh will provide clear perspectives for eranet cofunds national research funders and researchers in the agrifood and biotechnology sector to find dedicated support at the level of information communication cooperation networking and joint transnational funding that best fits their needs in turn geh will contribute to maintaining and strengthening eus highly competitive position in agrifood and biotechnology research