Dragon09/odtu_chatbot huggingface dataset:
the role of novel pkc kinases in integrin activation

integrins represent a family of cell adhesion receptors mediating cell interaction with the extracellular matrix ligands their ligandbinding activity is tightly regulated and when defective gives rise to thrombosis or inflammation and contributes to cancer progression to date the key steps of integrin activation in response to both extracellular and intracellular signals are well described however the counteracting processes resulting in receptor inactivation remain incompletely understood the host laboratory has pioneered research in this area by screening to identify integrin inactivating proteins involved in neuronal disorders cell migration and cancer although the novel subfamily of protein kinase c npkc has emerged from these screens as putative integrin inhibitors the role of these kinases in regulation of integrinmediated signalling remains to be investigated benefiting from my strong methodological proficiency in protein kinase research and the host laboratorys extensive expertise in integrin biology in cancer i aim to address the role of npkcs in regulation of integrin activation from both mechanistic and preclinical points of view i expect to identify new cancer relevant signalling nodes by executing mechanistic in vitro studies with specifically engineered kinase mutants stateofthe art cancer cell biology and imaging followed by in vivo preclinical cancer studies in cancer models and patient sample cohorts the result of this innovative and interdisciplinary project will represent a valuable basis for potential design of drug targeting strategy and therapeutic intervention not only for treatment of cancer but also of other diseases where npkcs and integrins are implicated
advanced lasers for quantum technologies

quantum technologies represent one of the fastest emerging hightech markets the growth in the production of quantumcomputers goes hand in hand with the need for more affordable and reliable components of their hardware in atomic quantumtechnologies frequencystabilised lasers are crucial elements that are used for cooling manipulating and detecting the qubitshowever most of the systems currently on sale in the market are conceived for a laboratory environment rather than for an industrialproduction and the very few turnkey systems that are available are bulky complex and expensivein aqlas we merge an innovative laser design and a recently developed technology on fiber interferometry to realize a newaffordable and compact laser module for implementing entanglement and highfidelity qubit readout in atomic quantumcomputers the new laser module overcomes comparable commercial systems in terms of size 4 to 10 times smaller and cost 2 to 5times cheaper in aqlas we start from a trl 4 proofofconcept that has already demonstrated in the laboratory and enclose it in a transportable 19 rack unit containing all the components which will represent out minimum viable product mvp with the mvp we will reach trl 5 by demonstrating the systems performance in the use case ie a qubit processing at a quantum computer company after this validation we will focus on transforming the mvp into an oem system for industrial production thusreaching trl 6 during the project we will establish a feasible business strategy that will be refined with potential customers andinvestors the funding readiness level will be elevated to 6 and we will create a strong ipr strategy with the goal of creating a newstartup for which a solid investment case is presentedaqlas will foster the quantum computing revolution and contribute in establishing a sustainable quantum computer industrypositioning europe as a leader in a new frontier technology
engineering carbon quantum dots for zinc ion hybrid capacitors

zinc ion hybrid capacitors zihcs integrate two energy storage mechanisms of batterytype electrode and capacitive electrode bearing the advantages in energy density power density and safety until now the cycle retention rate of zihcs capacity reported is still not more than 80 restricting its development and commercial application severely focusing on the issue the project aims at overcoming the limitation of traditional electrode materials and redefining the designing concept to construct carbon quantum dots cqds for zihcs advanced methods will be used to harvest carbon quantum dots from coal tar pitch a sort of industrial solid castoff the bulk sp2carbon network innumerable edge sites profuse surface functional groups and regular size ensures that assynthesis cqds have high electrical conductivity sufficient ion transport channels and rich adsorption sites moreover the new concept of dynamic evolution is introduced for insight into the structure and interface failure of zihcs electrode the interfacereconstruction mechanism and the attenuation model of capacity will be established for the first time further the methods to strengthen structures of cqd electrode will be developed based on a tradeoff strategy the ultimate goal is to improve the energy storage efficiency of zihcs by 20 and to increase their cycle performance more than 95 unprecedentedly this research will develop longrunning high performance zihcs for contributing european energy storage industry the er will achieve abundant research experience and scientific skills from the project and the capability to launch her own research group in future
hybrid polymer nanoparticles as gene vectors

gene therapy has long been seen as a promising solution to unmet clinical needs and the licencing of gene therapy sarscov2 vaccines has provided a flavour of the technologys potential however gene therapy still faces significant challenges in clinical and commercial translation including the need for effective and safe delivery vectors polymeric nanoparticles offer great flexibility in gene vectors design improved stability and easier scaleup of production compared to lipid nanoparticles but often suffer from cytotoxicity and underperformance in vivo the goal of hyplex is to develop the next generation polymeric nanovectors which can easily be functionalised to further improve delivery efficacy the project will develop novel chemistry to achieve polylysinepolyacrylate hybrid nanogels functionalisation of nanogels will be demonstrated by the introduction of mannose a common cell binding motive as well as diethylene glycol ethyl ether arylate to optimise the hydrophilichydrophobic balance in an interdisciplinary approach gene loading and cell transfection will be studied up to in vitro level the project results will be exploited as part of an ongoing commercialisation initiative at rcsi which will provide the applicant with a unique experience in research translation and commercialisation the highlevel science is complemented by bespoke training activities which will significantly advance the career opportunities of the applicant project results will be communicated to peers as well as the public with specific focus on encouraging female secondary school pupils to take up scientific careers
applying reactive twins to enhance monument information systems

the artemis proposal addresses the field of cultural heritage conservation restoration safeguard and valorisation by advanced digital technologies using digital twins and relying on advanced arvr technologies it relies on an extended digital documentation of heritage assets with 3d models incorporated in their digital twins by implementing services on heritage data that model the behaviour of the realworld assets in different conditions and under the effect of complex external phenomena the same approach will allow digital experiments testing the effect of activities simulated on the twin whenever suitable the developed services will avail of arvr techniques to manage the simulation input and to visualize the outcomes artemis will rely on the knowhow of participating worldclass research infrastructures making available a huge amount of heritage documentation data on the contribution of advanced research centres and on the support of specialized technological smes the project will produce a scientific methodology tested on a large number of pilots and will pave the way for innovative applications in heritage research based on digital twins and arvr techniques
cloud doctoral network

clouddoc is to establish a network of early stage researchers esrs all phd students at 12 institutions across europe 10 eufunded the role of aerosol nucleation for atmospheric aerosol clouds and climate is investigatedthe focus of investigations will be to study under wellcontrolled laboratory conditions the oxidation chemistry aerosol nucleation and growth processes that are responsible for aerosol particle formation in cold regions of the atmospherea arctic environments b the upper troposphere above the asian monsoon regionc the upper troposphere above tropical rain forests andd the southern ocean the major research activity of the network will be two sets of joint experiments carried out at the cloud aerosol chamber at cern to which all esrs contribute at the cloud chamber nucleation experiments are performed at an unprecedented level of precision and completeness using highly innovative instrumentationa wellstructured research and training plan is set up for every esr as well as a comprehensive qualitycontrolled supervision a highquality phd training is arranged the esrs are brought together for network training events such as summer schools and workshops for integral data analysis courses by worldleading experts are taught spanning from general atmospheric aerosol chemistry and physics to specialized sessions including the role of aerosol for clouds climate and also health the summer schools and workshops are specifically tailored to the needs of the trainees transferable skills training includes courses on scientific writing presentation skills interaction with media entrepreneurship ipr management gender dimension and diversity in science and good scientific conduct the partners from the private sector 1 beneficiary 4 partners are closely integrated in the action
sustainability certification for biobased systems

sustcert4biobased project is set on fostering the adoption of effective and robust sustainability certification schemes and businesstobusiness labels for industrial biobased systems to support tracing the sustainability of biobased products along the value chains and trades within the eu and globally for responsible production and consumption to this end a monitoring system will be developed with a lifecycle perspective along four themes environment social economic and governance considering the complexity and relationships of all dimensions of sustainability and the rules and procedures on how the schemes are managed this system will be optimized with pilot audit in practice and testing on existing schemeslabels for biobased systems evaluating their performance in the different themes and their coverage of the list of minimum requirements costs and benefits from the adoption of certification schemes and labels will be assessed considering actual economic as well as internalized environmental and social ones data will be generated on volumes of biological resources and biobased products in global trade flow and extent of their certification we will leverage the results of the project to provide best practices and recommendations to 4 key target groups policy makers sustainability system community industrial biobased value chain actors and regionalrural bioeconomy stakeholders our vision is that this will result in harmonized system requirements continuous improvement and enhanced adoption of sustainability certification schemes and labels and provide a significant contribution towards establishing a circular and sustainable biobased industry for europe contributing to the bioeconomy strategy and green deal the large multisectorial stakeholders involvement through an international network of interest domain and a comprehensive advisory board will enable sustcert4biobased to increase outreach and aligning with ongoing international efforts
formation and evolution of exocometary discs

the last two decades of exoplanet discoveries have revolutionised our view of planetary systems and our place in the cosmos bringing us closer to answering fundamental questions about how these systems form and evolve these advancements have however mainly focused on the inner regions of these systems due to the difficulties of probing their colder outer regions despite their importance for the formation and evolution of planets these barriers are nevertheless breaking thanks to observational campaigns led by me and others with alma studying exocometary discs analogous to the kuiper belt and jwst searching for subjupiter mass planets at tens of au this erc program aims to constrain how the outer regions of planetary systems and in particular the debris of which exocometary discs are made form and evolve such an endeavour will require transforming our understanding of three key and interconnected pillars first we must understand how exocometary discs form as their structures encode key information about planet formation processes this will require developing the first holistic models for exocometary disc formation and their comparison with alma observational constraints second we must study what processes shape exocometary discs after formation to be able to use disc observations to infer the dynamical history of systems this will require studying the disc interaction with planets and even stellar encounters while systems are young and comparing the outcome of these interactions with jwst and alma observations third we must advance in our understanding of exocometary gas as it could allow us to infer the presence of planets affect their atmospheres and the distribution of exocometary dust biasing our dynamical inferences only by developing these three pillars we will truly advance in our understanding of exocometary discs a key element fordeciphering planetary systems
from the mediterranean to the indian ocean through ethnoarchaeology of fuel and archaeobotany

the objective of this project is to study energy procurement practices and its relationship with environmental economic and social sustainability to do so we aim to carry out ethnoarchaeological fieldwork regarding fuelrelated practices among the vedda indigenous communities in sri lanka in parallel we will develop archaeobotanical research to interrogate these questions in prehistoric and early historical periods of the island the building of a wood reference collection will be key and will boost the development of proper charcoal analyses the results of this research will be integrated to create an educational resource for museums botanical gardens and schools with the aim to bring the study of humans and plants interactions to the general public this project requires f different methodologies whose field of expertise facilities and knowledge are shared between academic and nonacademic organizations in france spain and sri lanka for the successful development of the project we involve 21 persons with different categories phd students postdoctoral and senior researchers technicians and members of nonacademic organizations developing a total of 64 months of secondments in the institutions involved this project will set up the basis for sustainable collaboration between academic institutions working on archaeological charcoal and ethnoarchaeology of fuel and nonacademic institutions engaged in educational resources on ethnobotany and the diversity of human uses of plants the project is organized in 5 packages including four objectives and the management and dissemination of the project the research will be carried out through longterm secondments by phd students and shorter secondments by senior researchers and nonacademic members this project will provide scientific impact by delivering training and resources for the study of charcoal remains and socio and economic impact throughout the production of an educational resource
twodimensional high entropy alloys and ceramics

entropy engineering recently had exceptional impact on bulk materials science by invention of bulentropy engineering recently had exceptional impact on bulk materials science by invention of bulk high entropy alloys and ceramics the underlying idea is that by equiatomically adding 5 principal elements to alloyscompounds the much increased configurational entropy stabilizes otherwise nonaccessible single high entropy phases with an unique random elemental occupancy on a crystalline lattice and hence novel functional properties likewise reducing dimensionality in twodimensional 2d materials recently had exceptional impact on materials science due to the 2d materials unique functional properties despite these exciting individual prospects of entropy engineering and 2d materials combination of these two concepts to synergetically create novel 2d high entropy materials 2d hems as a novel materials class with novel functional properties with possible applications in electronics and catalysis remains lacking in highentropy2d we will fabricate unprecedented 2d hems 2d high entropy alloys oxides and sulfides using for the first time scalable vapour deposition and a 2d template2d confinement approach for both 2d film and 2d nanoflake form asses their novel properties and perform first tests of their applicability for electronic devices and catalysis reducing hem dimensionality to 2d will also create a unique opportunity to for the first time study in situ and at the atomic scale currently unknown fundamental diffusion crystallisation phase transition and separation mechanisms in hems using a globally unique scanning transmission electron microscopy stem setup to obtain fundamental insights relevant to hems even beyond the here newly introduced 2d hems the proven track record of principal applicant bernhard c bayer in 2d materials synthesis and atomic scale in situ stem is an ideal basis for this ambitious research programme
exploration of backendofline compatible tebased ptype transistors with 2d material van der waals contacts for monolithic 3d integration

the performance enhancement of integrated circuits relying on the downscaling of transistor dimensions following moores law is becoming more and more challenging as silicon is reaching its physical limit thus monolithic 3d integration has been considered as a powerful method to improve system performance further this requires that transistors be stacked on top of each other at backendofline beol compatible temperatures to avoid degradation of underlying devices twodimensional 2d semiconductors are promising candidates for such beol transistors but most advancements in terms of device performance and reliable beol integration concern ntype devices while ptype is still lagging behind hence better ptype beol transistors are highly sought after to enable complementary metal oxide semiconductor cmos technology one of several challenges for ptype devices is contact resistance because wide band gap 2d semiconductors typically have large schottky barriers between the metal contact and their valence band tellurium te and its compounds have recently been identified as promising candidates for beol ptype 2d transistors which offer decent access to their valence bands integration at beolcompatible temperatures and good material prospects for device performance however research on such devices is still in its infancy and drive current stability passivation and contact resistance still need improvements thus in this work we propose to advance the research in tebased ptype devices in particular we will experimentally explore the potential of 2d material van der waals contacts furthermore we will evaluate the cmos logic circuit performance coupling with its ntype counterpart and the prospects of our devices for monolithic 3d integration through simulation
improvised music and decolonisation

in the course of the 20th century musical improvisation became strongly associated with emancipatory politics as expressive freedom in music symbolised forms of societal cultural and political freedom more generally in the 1960s european improvisers distinguished their free improvisation from jazz and other improvisatory music by calling it nonidiomatic ie not drawing on previously existing musical styles although the genre of free improvisation has formed a unique space of transnational and intercultural collaboration such a utopian understanding risks an erasure of actual forms of inequality and exclusion after all to draw on ones own musical tradition inevitably means to play in a specific idiom to what extent has this definition of freedom as nonidiomatic playing excluded the participation of musicians of colourthe aim of this proposal is to understand the politics imbedded in free improvisation in a european postcolonial context we investigate the hypothesis that nonidiomatic music constructed a form of musical whiteness in the spheres of musical practice discourse and institutions we develop a novel understanding of musical idiom in terms of differentiation rather than convention and we describe how questions of freedom and idiom were negotiated in musical practice as a case study we investigate the musical practice of improvising musicians from former dutch colonies active in the netherlands after world warr ii ca 19452000 and analyse how they negotiated their position between the idiom of jazz a supposedly universal nonidiomatic form of improvisation and their own musical traditionsthrough archival research oral history and the analysis of musical practices improdeco will make a fundamental contribution to jazz historiography postcolonial perspective on dutch music history musicological theories of improvisation and to current debates about racial inequality in dutch music and society
twinning of magnetic resonance imaging research institutes

magnetic resonance imaging mri is known as the most versatile and advanced medical imaging modality capable of producing tomographic images emphasizing different tissue material properties and hence facilitating the diagnosis of a wide range of anomalies the complexity and the importance of mri make it a specific research field with dedicated research centers throughout the world bilkent universitys national magnetic resonance research center umram in turkey is an established mri research center with an excellent research track record but limited access to european research networks the he twinning program aims at networking research institutes from the widening countries such as turkey with their advanced counterparts in europe to integrate widening countries into the european research network in order to integrate umram into the european research networks bilkent universityumram as the coordinating partner together with german cancer research center dkfz germany universittsklinikum freiburg germany and university of nottingham uk as advanced partners are forming a team to conduct an eu horizon twinning project mritwins in the field of magnetic resonance imaging the project teams research expertise lies in the field of mr engineering where novel hardware and enabling software is developed for mri beyond the shortterm goals of the twinning project this team is formed to make a longterm impact on mr engineering research by joining their complementary expertise to initiate a longterm research collaboration between the project participants the twinning program allows for an exploratory research component limited to 30 of the total budget the scope of the mritwins project includes research work where highly credible project partners will explore the topic of reengineering mri scanners with opensource hardware and software with a specific focus on the novel gradient and radiofrequency array technologies