Dragon09/odtu_chatbot huggingface dataset:
magnetic nanographenes synthesis and characterisation of structurally defined nanographene fragments containing paramagnetic metal ions

the development of tailored nanomaterials for quantum technologies is urgently neededcurrently polydisperse materials such as conducting polymers graphene nanoribbons carbon nanotubes etc lead the research field of organic electronics while nondiscrete systems based on inorganic solids as nitrogenvacancy centers in diamond or certain defects in si are ahead in most applications in nanotechnology these areas of research progress towards the creation of smaller and more functional devices promoting the invention of more and more sophisticated methods to control them one of the main barriers of this evolution is the lack of materials that offer reproducibility and scalability as well as stability and functionality with that regard molecular materials provide promising prospects due to their defined chemical structure high processability and because they can be tuned in a rational way by chemical designthe preparation of molecular materials containing magnetic functionality spin centers and the ability to transport electrons a conjugated organic framework is still very limited due to the lack of synthetic protocols even though graphene is the most popular platform for organic electronics and magnetism the insertion of spin centers in graphenelike materials has been scarcely explored in this project i aim to develop an efficient protocol for the preparation of hybrid nanographenes that compete with nondiscrete materials
nonlinear excitation of ideal anapoles

anapoles are nonradiating states of light in which optical fields are trapped by destructive interference of outgoing radiation they have recently attracted significant interest due to their potential in resonant nanoscale light confinement which could be used in lasers sensors quantum computers and other areas of lightbased research and technology however ideal anapoles have never been experimentally achieved because making them perfectly decoupled from external radiation would prevent their excitation and observation the proposed project will resolve the above issues advanced theoretical modeling tools will be used to design the ideal anapoles that can be excited through secondharmonic generation in this process the incident light would illuminate the anapolar nanoresonators and nonlinearly induce local optical fields matching the anapoles excitation at twice the incident light frequency secondharmonic optical fields may form configurations that can not be induced through linear interactions with external optical fields hence allowing these local fields to be fully decoupled from external radiation these local nonradiating fields will then induce photoluminescence at optical wavelengths detuned from the anapoles resonance detecting this photoluminescence will enable probing the anapole excitation to demonstrate this concept in experiments resonant photonic samples will be fabricated in the silicon nitride si3n4 material platform integrated with molibdenium disulfide mos2 monolayers which can simultaneously support efficient secondharmonic generation and photoluminescence the samples will be excited by timecontrolled ultrashort laser pulses enabling investigation of the temporal dynamics of the anapoles local optical fields and retrieving their q factors demonstration of the ideal anapoles is an ambitious and challenging goal with breakthrough potential for the research on confined states of light and their possible applications
health simulations ethical and societal challenges of digital twins

digitisation has an impact on even the most fundamental concepts in medicine and public health including our ideas of health and illness embodiment vulnerability and controllability among the emerging technologies driving this paradigm shift is that of digital twins dt which presents exceptional challenges to healthcare governance raising ethical and societal issues of which our understanding is still rudimentary dt may be empowering but could also exacerbate the vulnerability of both individual patients and the population at large there are substantial gaps in our understanding of whether these new forms of artificial intelligencedriven health simulations provide new ways of engaging with experiences of human vulnerability or whether they in fact introduce new forms of harm in this context simtwin will be the first project systematically identifying and examining the ethical and societal implications of the use of dt in healthcare in doing so simtwin will promote our understanding of and practical approaches to new forms of simulation and prediction of health trajectories simtwins central objective is to provide a comprehensive and indepth analysis of the normative challenges implied in order to develop an integrated theory of health simulations in proposing an empiricallybased and normatively robust framework for an ethical and societal assessment of this technology simtwin will enable the design of practical modes of controllability for the use of dt in healthat a moment in history in which our societies find themselves facing crucial decisions on how to approach the complex issues raised by the dual simultaneously transformative and disruptive character of health simulations simtwin promises groundbreaking insights into the associated normative and societal challenges and key orientations for a robust and innovative governance framework
era chair for accelerated synthetic chemistry technologies at palack university olomouc

to unite a powerful potential of two outstanding research leaders and thus capitalize on their mutual collaboration for reaching the impact none of them would achieve on their own this is the aim of the accelerator project it brings together 1 the worldrenowned professor of chemistry inventor and innovator alexander dömling as an era chair of the synthetic group and 2 the czech advanced technology and research institute catrin of palack university olomouc up merging three excellent research centres into a unique scientific ecosystembetter links between ri actors across european research area era and beyond is a must if europe is to maximize excellence from across the continent up has been pursuing this goal for a long time now to become a pocket of excellence and an advanced research trendsetter up needs to yet i enhance the excellence and strengthen its position in era ii streamline the ri commercialization system and establish new industrial partnerships and iii foster brain circulation to attract outstanding scientistsso far unconquered issue of automation in synthetic chemistry innovative compoundbased wholeplantscreening technologies for securing food supply novel antibacterials addressing the challenge of increasing antimicrobial resistance and breakthrough materials for batteries and supercapacitors enabling energy storage from renewable sources are just few challenges awaiting to be solved by the accelerator the project that has all prerequisites to rise the era chairs expected impact to its fullnessproject will lead to 1 the increase of the ups research excellence 2 institutional changes at up through strengthening the innovation knowledge transfer ecosystem in olomouc region 3 improved capability of up to successfully compete in international research funding 4 securing the longterm sustainability of the synthetic chemistry research group after the completion of the project
deep labelfree cell imaging of liquid biopsies for cancer monitoring

we will develop and commercialize an innovative device for diagnosis and monitoring of cancer in liquid biopsies based on a labelfree interferometric phase microscopy ipm unit coupled with dedicated realtime artificial intelligence ai for cell classification this device will materialize an innovative approach for the muchanticipated imaging flow cytometry dramatically decreasing its costs and improving patient care by accurate monitoring of cancer in the clinical lab from a simple lab test liquid biopsy the success of the project is dependent on four highriskhighgain aspects a building the first clinical ipm device b designing and manufacturing a disposable microfluidic device for imaging flow cytometry c obtaining highenough acquisition and processing throughput in imaging flow cytometry of urine samples d training a deep natural network to detect cancer cells based on the informationdeep labelfree ipm images of cancer cells during flow the proposed poc project stems from my ongoing erc stg project that focuses on the application of ipm for grading the metastatic potential of cancer cells as a basicscience research tool
healthy ship 4u

hs4u offers an evidencebased approach extending standardized design and regulatory paradigms towards industry 50 the project is promoting principles of modularization optimization and smart systems engineering towards the detection prevention mitigation and management of large passenger and cruise ships hence hs4u holistic solutions for stress relief over conditions of health crises prioritize the assessment of typical cruise designs and daytoday tasks following its two use cases celestyal and columbia blue and its 4unique pillars approach for research ie1societalhuman 2environmental 3technological 3legislation factors it adopts and delivers stateofthe art ecosystem of technologies offering groundwork to rethink health and safety designs and frameworks hs4u bridges crosssectorial multidisciplinary expertise to crossfertilize research findings and provide best practices protocolpolicy recommendation and a complete solution for crew training based on multiplayer gaming validation of proposed technology and passenger behavioral model will be based on live experiments special hs4us open sourcefair offerings arecollaborative digital framework cdf for live interaction of crewpassengers and iot edge devices on the ship based on corobotics concepts and artificial intelligence mechanisms and models viral detection sensor vds that will be developed tested validated delivered patented and commercialized to offer online indication of the location of pathogenic airborne spreads in indoor environmentsrobotcabin reallife demonstrator displaying evidencebased 4u solutions on the interoperability of smart and innovative methods for ship systems effective and fast detection prevention mitigation and intercompartment intracompartment management ensuring healthy ship operations and safe return to port over conditions of health crises
brightspace designing a roadmap for effective and sustainable strategies for assessing and addressing the challenges of eu agriculture to navigate within a safe and just operating space

the european green deal aims among others to increase the contribution of eu agriculture to climate change action improve the management of natural resources ensure a fair economic return for farmers and reinforce the protection of biodiversity eu agriculture and food practices are currently not on the right track to meet the green deal ambitions and objectives these objectives are interdependent and while often aligned they may also compete synergies and tradeoffs between socioeconomic and environmental outcomes are brought together in the concept of a safe and just operating space sjos where the safe component reflects the biophysical boundaries of the ecosystem and the just component the requirements for the wellbeing of the involved people policy makers and opinion leaders often lack sufficient information to gauge the likely effects of a sjos crises in their country the brightspace collaboration responds to this challenge by designing effective and sustainable strategies to navigate within a sjos brightspace provides an analytical toolbox to experiment analyse and coordinate the effects of innovative technologies governance structures as well as short and longterm policies related to agriculture thereby allowing for the execution of consistent coherent and lasting strategies with the desired consequences the project emphasises the diversity of challenges regarding the sjos across countries and regions and delivers new empirical evidence on causeeffect relations between drivers and outcomes relevant for the sjos a harmonised data framework and modelling toolbox are developed for mediumterm and forwardlooking projections of possible sjos futures by 2050 and beyond the support for effective and sustainable actions will include the identification of critical pathways for technological institutional and consumeroriented options for eu policies in the areas of agriculture climate change trade and energy
hydrogenelectric zero emission propulsion system

herops aims to introduce climateneutral propulsion into regional aircraft by developing mtus flying fuel cell ffc propulsion system concept for entry into service in 2035 this disruptive hydrogenelectric propulsion system uses fuel cells as sole power source and a liquid hydrogen fuel system without the need for highpower batteries integration of both the fuel cell system and the electric propulsion unit into a compact engine nacelle will ensure an efficient system at high powertoweight ratio herops targets to demonstrate a 12 mw propulsion system based on a scalable 600 kw core module at trl4 the core module and all further subsystems will be validated up to trl5 complemented by simulation and electrical network testing of the overall modularised system scalability to the 2 4 mw power level will be confirmed the certification programme will build upon ongoing certification activities enabling timely maturation of the aviationnative herops technology against relevant certification requirements the twophase approach of the overall programme including extensive development test and validation cycles at each stage is expected to advance the ffc concept to trl6 for integration and demonstration on a regional aircraft by 2028 it will pave the way for commercial prototyping and entryintoservice by 2035 delivering a key propulsion technology to reach the european green deals objective of climateneutral aviation by 2050 with 100 prevention of co2 and nox emissions and up to 80 reduction of the climate impact from contrails and contrail cirrus the herops project will meet this challenge with a european consortium of aircraft propulsion system integrators electrical system experts key tier 1 suppliers and leading researchers in stack technology mechanics and propulsion leveraging relevant and effective synergies between european and national programmes
high performance organic narrowband emitters for stable blue oleds

constricted by electron spin statistics the maximum internal quantum efficiency of 100 can be achieved in organic lightemitting diodes oleds by utilizing purely organic thermally activated delayed fluorescence tadf materials however due to strong charge transfer they exhibit broad emission with a fullwidthathalf maximum fwhm 70 nm recently multiresonant tadf mrtadf emitters a subclass of tadf materials based on alternating boron and nitrogen atoms embedded into polycyclic aromatic hydrocarbon scaffolds are attracting much interest in oleds their key attributes include a narrow fwhm high photoluminescence quantum yield and unprecedented color purity even though these mr materials have advantages in color purity over conventional tadf materials their device stability is weak and results in a poor operational lifetime lt due to the large singlettriplet energy gap delayed fluorescence lifetime and too slow rate of reverse intersystem crossing risc especially narrowband blue oleds lt 100h is still inferior to the conventional tadf oleds the honesty project seeks to address the above issues by rationally designing organic narrowband novel tadf emitters our designs comprised four types a combination of boron and nonboron targeting a high risc rate leading to highly stable narrowband blue oleds with long lt among the four types one design includes yet unexplored rigid telluriumbased acceptor decorated with high triplet energy donors which is keen for new tadf scaffolds the rigidity of all chemical components with slightly twisted confirmation and aryl groups on donors will work coherently to furnish highly stable oleds with suppressed efficiency rolloff improved device stability and long lt overall the honesty proposal is anticipated to provide a breakthrough in stable blue narrowband tadfoleds with the supervision of karolis kazlauskas a physics expert in stable oleds working at vilnius university lithuania
detecting epigenetic biomarkers in the blood for noninvasive precision oncology

the detection of circulating tumor dna allows to noninvasively retrieve tumor molecular profiles and follow disease evolution these approaches promise optimal and individualized management of patients with cancer however despite remarkable progress several technological obstacles still limit liquid biopsy widespread application indeed detecting small fractions of tumor dna released when the tumor burden is reduced remains a challenge samples collected at early stages or during treatment may contain less than one mutant copy per milliliter of plasma which is below the detection limit of current technologies moreover detectable recurrent mutations do not cover all patients it is therefore necessary to develop new more sensitive but also more informative tools my goal is to develop new methods detecting epigenetic markers from peripheral blood for establishing more efficient noninvasive diagnostic tests and disease monitoring targeting the cancer epigenome which contains a myriad of somatic alterations that do not modify the dna sequence and cover cases without detectable mutations will achieve increased sensitivity these markers could become decisive in detecting residual disease and early stages of multiple forms of cancer i will develop approaches to 1 analyze circulating dna methylation profiles at unique and repeated sequences 2 identify circulating dna cells of origin using nucleosome footprint 3 analyze transcripts associated with circulating extracellular vesicles ultimately a single test integrating dna methylation profiles fragmentation patterns and evassociated transcripts from the same plasma sample will be developedthis project has both fundamental and biomedical implications it will generate indepth knowledge of the biology of circulating nongenetic tumor biomarkers and lead to the development of more efficient noninvasive diagnostic tests adapted to all types of cancers based on the universality of these factors
radical chemistry with the hydrogen atom through water activation

water activation which allows the transfer of universally abundant hydrogen into value added compounds is an important research field in modern science this task has been realized mainly by using transitionmetalbased systems herein we will use a conceptually novel mild water activation strategy which proceeds through a photocatalytic phosphinemediated radical process the active species in these processes is a metalfree r3poh2 radical cation intermediate where both hydrogen atoms are used in the following chemical transformation through sequential heterolytic h and homolytic h cleavage of the two oh bonds the r3poh radical intermediate provides an ideal platform to mimic the reactivity of a free hydrogen atom that can be directly transferred to various systems to give hadduct cradicals which are eventually reduced by a thiol cocatalyst leading to overall transfer hydrogenation of systems with the two hatoms of water ending up in the product the driving force is the strong po bond formed in the phosphine oxide byproducthydrogenation of alkenes arenes and heteroarenes will be investigated also addressing stereoselective reductions using chiral hdonors deuteration and tritiation with d2o and t2o as formal reductants will be explored experimental studies will be supported by dft calculations throughout the studies polar effects exerted by the hdonors will be studied which will allow the design of more complex intramolecular and intermolecular reductive cascade reactions comprising cc bond forming steps reactivity of the novel r3poh radicals towards various functionalities will be systematically investigated and the reactive functional groups then incorporated into cascade reactions atomeconomic radical htransfer isomerization reactions that proceed with pbased catalysts will be developed finally photoactive pcompounds will be used as mediators for water activation in hydrogen atom transfer radical chemistry
rethinking the design of streets and public spaces to leverage the modal shift to climatefriendly active transport everywhere

drastic decrease in transport emissions of 55 by 2030 and 90 by 2050 is required for european cities to reach climate neutrality this is hindered by inconvenient mobility infrastructure inadequate services and insufficient governance for shortdistance travel negatively impacting active modes safety and security reallocates main objective is to pave the way towards climateneutral safe inclusive and smart european cities through integrated and innovative sustainable urban mobility solutions that will address the needs of diverse groups and communities while rebalancing street space allocation the project will empower 10 twinned mission cities gothenburgtampere heidelbergutrecht lyonwarsaw budapestzagreb barcelonabologna by providing horizontal thematic expertise supporting them to build a local innovation ecosystem to develop and deploy zeroemission shared inclusive active and humancentred mobility interventions pilots in 15 urban and periurban unsafe areas will demonstrate innovative urban space management and reallocation strategies for sustainable modes with a specific focus on active modes having in mind safety inclusivity affordability and a just transition to climate neutrality overall solutions include innovative urban design behavioural nudging smart technological and datadriven solutions to reduce actual and perceived road safety risks all contributing to achieving climate neutrality by 2030 the pilots will be the learning and testing environments for integrated approaches to foster knowledge transfer and collaborative learning to staff in cities through mentoring and capacity building knowledge exchange twinning and work shadowing the projects impact will be exponentially increased by engaging 10 cascade cities in capacity building activities and providing them with replication packages and guidelines resulting in implementation plans for replicating at least one of the innovative solutions piloted
a biorefinery for upcycling coffee waste into sustainable healthy highvalue ingredients

kaffe bueno has developed an innovative model for upcycling coffee waste into highvalue ingredients coffee is highly bioactive with huge reservoirs of lipids melanoidins and phenols yet we currently use just 1 of its potential discarded coffee waste ends up in landfill producing methane and co2 or is reused as biofuel or compost kaffe bueno transforms this wasted resource into a business opportunity we produce high quality coffee oil melanoidins and ligninphenols as sustainable natural active ingredients sold b2b to manufacturers of cosmetics and personal care products helping denmark and the eu meet their targets for carbon reduction by 2030 we aim to valorise 100 of our coffee waste feedstock in this project kaffe bueno will build and optimise a demo biorefinery with the capacity to process 200 tons of coffee waste year using our efficient proprietary process then use equity to expand this plants capacity to 1200 tons and invest in r d for new applications