Dragon09/odtu_chatbot huggingface dataset:
precarious labour in asia exploring challenges and solution to labour insecurity through casestudybased evidence from 8 asian countries

a recent ilo report estimates that two billion workers are active in the informal economy the relevance of the phenomenon is even higher if the secondary effects of informal employment are considered and is likely to get worse given that climate change has come to increasingly affect those living in conditions of vulnerability pushing more people into the informal sector although informal economic activity is widely present in europe and north america constituting around 20 of the national gdp developing and emerging economies suffer disproportionately from this phenomenon for example the ilo estimates that africa asia and latin america host 93 of the worlds informal employment and have been on the rise due to the covid19 crisis altogether the world bank and ilo estimate that almost a billion people entered precarious work because of the pandemic with women and young people being the most affected categories prelab network includes academic and development organisations all with a major focus on informality and development to 1 train researchers in methodologies to measure informality in a global perspective 2 conceptualise ways to apply qualitative and quantitative methodologies that were successfully used eastern europe and central asia to our target countries in the asia pacific region 3 produce a consistent narrative on how to measure and tackle informality in emerging economies and 4 engage with policymakers and business actors in addition to the scientific community to identify ways to apply these approaches into development practice worldwide
deciphering the newly discovered branchial cavity immune surveillance system to protect fish against infectious diseases in aquaculture

the sustainability of aquaculture an important food source for human is severely challenged by infectious diseases unfortunately the development of new therapies and vaccines is hindered by our incomplete understanding of the fish immune system the lack of knowledge of the mechanisms governing immune responses in the branchial cavity is particularly alarming considering that it represents a main port of entry for pathogens and is involved in many pathologies affecting farmed fish recent findings of new lymphoid tissues bound together by a previously unknown tonsillike organ inside an even larger lymphoid network revealed the branchial cavity as an unsuspected important region of the fish immune system the main objective of this project is to characterize this newly discovered branchial cavity immune surveillance system to harness its potential against infectious diseases in aquaculture toward this goal the project will take advantage of the zebrafish model to achieve the following objectives 1 characterize the newly discovered lymphoid tissues and tonsillike organ 2 decipher the rules of antigen sampling and transport in the branchial cavity 3 characterize the development of the branchial cavity lymphoid architecture 4 decipher the roles of the branchial cavity immune surveillance system in immune responses to infection and vaccines in a comparative effort the project will then study the branchial cavity immune system in atlantic salmon and other fish species relevant for aquaculture the methodology will combine sophisticated immunohistology nanotechnologies stateoftheart transcriptomic analysis antibodyassays and advanced 3d microscopy the project will progress far beyond the current knowledge in fish immunology which could drastically impact current paradigms in the field open new perspectives for fish vaccination and diseases monitoring in aquaculture and has the potential in the long term to positively impact human health
harnessing the catalytic potential of nitrogenases

biological nitrogen fixation is natures alternative to the industrial haberbosch process that currently feeds at least half of the human world population through the provision of nitrogen fertilizers in addition to its high energy demand the process increasingly leads to various ecological problems as its annual output steadily grows with demand haberbosch ammonia synthesis leads to the release of the greenhouse gases co2 and n2o and to eutrophication of waters and aquifers because a substantial portion of nitrogen is lost to competing chemical and biological processes one solution for this is to transfer the enzyme directly into food cropsgofixit will establish the recombinant production of a complete nitrogenase enzyme system in a heterologous host and make a link to central metabolism effectively converting the host into a functional diazotroph nitrogenase is a twocomponent metalloenzyme that is uniquely able to reduce chemically inert atmospheric n2 into its bioavailable form ammonium it occurs only in prokaryotes is highly sensitive to o2 and it requires large amounts of metabolic energy in form of atp and a strong reductant for catalysis to obtain a functional production system all these points must be addressed in parallel based on our long record of research on nitrogenases we are ideally positioned to succeed focusing on our unique competence in preparative protein biochemistry and analysis we have produced isolated and structurally characterized all three nitrogenase isoforms and developed the spectroscopic and structural tools for a detailed analysis of their intricate metal cofactors gofixit focuses on the production of the enzyme components and based on their analysis chooses tunes and applies the required accessory machineries for the synthesis maturation transfer and insertion of the catalytic metal centres that are unique to this class of enzymes
hybridelectric regional fuselage empennages

the aim of herfuse proposal is to design innovative fuselage and empennages suitable for the future hybridelectric regional aircraft her that will contribute to the overall target to reduce green house gases ghg emissions herfuse will study the challenges on fuselage and empennages layout material components manufacturing and assembly derived by integration of the relevant fuselage systems for her as defined in the sria for a hybridelectric regional aircraft and in her01 topic herfuse integrates features and components necessary to regional hybridelectric propulsion and complementary systems as well as improves weight durability aerodynamic efficiency and operational issues the technologies and solutions matured in this project shall be aligned and feed with models analyses and actual test data hera project on regional aircraft horizonjucleanaviation202201tra01 herfuse technologies manufacturing and assembly of critical components will make feasible achieving the targeted performance gains of her enablers such as low ghg energy sources batteries and fuel cells their storage probable liquid in hydrogen case their distribution and management operational and safety features thermal management provisions electrical and thermal insulation technical solutions set by the herfuse will contribute then to the overall target and studies performed at aircraft level in hera to reduce emissions namely herfuse integration requirements will be concurrent and complementary to the aircraftlevel ones set into hera
deterministic e2e communication with 6g

digitalization is transforming industries and society with the adoption of edgecloud computing ai and digital twins in the future physical processes collaborating machines but also novel humansysteminteractions will move towards a cyberphysical continuum merging the physical world of senses actions as well as their digital programmable representations fundamentally new requirements for deterministic communication with predictable performance will appear for such cyberphysical endtoend services wired deterministic communication standards have already emerged including time sensitive networking tsn and deterministic networking detnet while 5g has specified mechanisms for interworking with those standards however the available support of 5g in conjunction with tsn and detnet is not sufficient for future endtoend timecritical applications driven by pivotal use cases from industry 50 deterministic6g addresses three central challenges of future deterministic endtoend communication enabled by 6g 1 a new architecture for 6g systems providing predictable performance and integrating it endtoend with tsn and detnet 2 novel datadriven awareness of stochastically evolving network performance with time synchronization over heterogeneous domains and 3 leveraging novel digital twins of both 6g networks and cyberphysical systems to anticipate situational circumstances impacting determinism of networks and safety of cyberphysical systems deterministic6g will also devise securitybydesign for deterministic communication including the integration of edge computing and the support of opc ua into deterministic network paths the project targets dissemination of results towards the three essential standardization bodies in this domain 3gpp for 6g ieee8021 for tsn and ietf for detnet with a strong consortium driving these standards deterministic6g will ensure uptake of the results and insights towards global 6g standards and industry fora
quantifying the completeness of the stratigraphic record and its role in reconstructing the tempo and mode of evolution

darwin identified the incompleteness of the geological record as a major concern in our ability to reconstruct the evolutionary history from fossils geological strata are not however a random selection of the past but are deposited and preserved in processes which can be modelled mathematically this project employs numerical forward modelling a technique from sedimentary basin analysis to quantify how stratigraphic gaps affect evolutionary patterns in the fossil record it focuses on tropical carbonate platforms because they are the richest archive of biodiversity through the phanerozoic and are directly formed by organisms thus preserving a positive feedback loop between the environment evolution and sediment formation completeness of the record depends on the time scale of measurement previous work demonstrated that long gaps in the record in the range of 106107 years are reflected in biodiversity reconstructions here we address shorter gaps 103105 years which are more frequent but harder to detect they can be predicted using models of stochastic sedimentation astronomical forcing and sedimentary and diagenetic selforganization forward modelling will be used to simulate the effect of gaps in the record produced by each of these processes on diversity and character evolution this will allow us to answer the questions what part of diversity do we miss owing to the missing rock record are the preserved intervals exceptional or representative is there a systematic part of biodiversity and environmental records which will always fall into gaps by applying the findings of the forward modelling to fossil successions we will be able to identify and correct for the missing parts of the record and formulate testable hypotheses on the original tempo and mode of evolution at the highest temporal resolution achievable in the geological record
nextgen ultrasound imaging by closing the perceptionaction loop

ultrasound us can revolutionize and democratize medical imaging if it offers 1 access for everyone and 2 excellent image quality iq mri offers 2 but is expensive and will thus not likely be able to provide 1 lowcost us hardware technology will enable 1 in the future but is not expected to yield the needed breakthrough for 2 consequently any paradigmshifting advance in signal processing technology that achieves us with excellent iq will have a huge impacti propose a conceptually new and highlyunconventional approach that i believe can lead to a new generation of us technologies with excellent iq i will formally describe us systems as intelligent autonomous agents that perform actions and perception using probabilistic inference the action is the acquisition probing the world and the perception is the reconstruction that infers what anatomy most likely generated the acquired us data i conclude that current us systems are in essence flawed agents since 1 actions are not driven by perception ie the perceptionaction loop is broken and 2 their generative perception models are naive my proposal will address this by closing the perceptionaction loop and offering strong perception models based on advanced deep generative networks this breaks a fundamental tenet in us imaging where i put forth the important concept that the acquisition and perception should work together to identify the point on the lowdimensional manifold of pure anatomy described by the generative model that is being imagedmy intelligent us agents will pursue excellent iq under the heading of a single probabilistic principle minimization of surprise under the agents own prior belief the generative model that such highquality images can indeed be achieved with this we open a new frontier within active imaging in us and beyond where data acquisition and information processing are treated jointly based on expressive generative density functions
standardized approaches to modelling and examination of neuropsychiatric disorders

port in wrocaw is a young government institution that conducts cuttingedge research and promotes the commercialisation of scientific discoveries the aim of the twinning project is to place the life science and biotechnology centre lsbc of port in an international network of european biomedical research this will be achieved by intensifying collaboration with leading neuroscience centres from france germany and the netherlands the scientific focus of this initiative stems from the shared vision of the consortium partners to develop new solutions for neuropsychiatric diseases it is estimated that 27 of the eu adult population suffers from at least one mental disorder these statistics are largely due to inadequate understanding of the biological basis of the disease leading to suboptimal therapies recent studies have discovered numerous genetic risk factors for mental disorders the next step is to investigate their contribution to diseaserelated phenotypes using standardized approaches to modelling and examination of neuropsychiatric disorders the sameneuroid aims to adopt in port the methods developed in the partner laboratories in order to achieve a consistent experimental workflow to facilitate the discovery and validation of new therapies consortium partners will support the lsbc in boosting the technical skills and management excellence while educational resources will be utilized to accelerate the formation of the next generation of welltrained scientists interdisciplinary activities will be organized to disseminate the unified toolbox and crosspollinate the existing academic and commercial environments a comprehensive communication campaign for promoting our results among stakeholders will increase the competitiveness and visibility of port in the international research community collectively the sameneuroid will be a true milestone for positioning lsbcport as a new hub of excellence for neuroscience in the era landscape
open and cocreated virtual worlds for europe

europe calls for the emergence of virtual worlds that characterises themselves for being open transparent inclusive ethically and environmentally responsible but also capable of restoring the technological sovereignty of eu industry in the global scenario of competition such european virtual worlds would foster the following benefits a higher accessibility greater freedom and control lower barriers to entry and more equitable distribution of resources b interoperability privacy and security as well as data ownership open humancentric virtual worlds would be able to interoperate with each other c more innovation creativity and social benefits open humancentric virtual worlds would foster a collaborative environment where developers and users could work together to create new experiences and features in that regards the overarching aim of openverse is to contribute to laying the foundations of such european virtual worlds by establishing a knowledge base on it setting up and animating a community of stakeholders testing a methodology that combines user cocreation and xr in real world cases of industrial and societal relevance exploring relevant ethical legal ipr and governance challenges and producing industry standards as well as a technology and policy roadmap and recommendations to guide the future establishment of the open virtual worlds concept in europe and worldwide
development of photonic multisensing systems based on moleculargates biorecognition and plasmonic sensors

in the current world there is a clear need of advanced multisensing systems capable of providing fast and quantitative detection of a huge range of hazards which could affect human health in our daily life sectors such as healthcare food safety or environment control among others will require these tools to take fast and effective actions and prevent potential crisis impact in this context photongate aims to develop an adaptable diagnostics solution comprising photonic cartridges and readout platform which allow to quantify multiple analytes of the same or different nature biomolecules chemicals metals bacteria etc in a single test with levels of sensitivity and selectivity ator over those offered by current commercial solutions photongate technology relies on a new sensing concept which combines two core technologies a biochemical technology molecular gates which will confer the specificity and increased sensitivity to the system and on the other hand a photonic technology light interaction with local surface plasmonic resonance lspr structures working as transducers and allowing the quantification photongate consortium has been specifically designed for maximizing the project success since all the actors of the value chain are enrolled in addition the development and integration of the different photongate components have been designed searching for the european autonomy by using european research knowledge and fabrication networks as well as favoring european providers photongate goals will involve a significant progress beyond the stateoftheart in multisensing systems achieving faster and high sensitivity detection of multiples targets a final validation of photongate technology in relevant scenarios for health and food safety trl5 will be performed to demonstrate the system capabilities
dissection of microglial state biology in brain repair

microglia the macrophages of the brain are critical regulators of many neurobiological functions and implicated by human genetics in several central nervous system diseases recent studies have revealed that microglia can adopt distinct coexisting subtypes termed states microglial states appear especially in the context of damage disease or repair and understanding these states may lead to the ability to precisely modulate neuroinflammation however due to a lack of datasets and tools the dynamics and functions of these microglial states are unknown representing a poorly explored frontier of neurosciencethe core goal of this proposal is to understand the kinetics and biological roles of microglial states using focal brain repair in the mouse as a model system i will address this knowledge gap with three synergistic objectives first how do microglial states change in space and time to answer this i will unravel the dynamics of microglial states by generating a spatiotemporal atlas of gene expression at the singlecell level from injury to full repair second how do specific microglial states emerge and what are their functions i will address this question by focusing on one state that interacts with the peripheral immune system and appears to be triggered by a particular cytokine finally i will build novel molecular tools to genetically access and specifically arrest any microglial state this will enable me to investigate their impact on remyelination and uncover the biological mechanisms by which microglial states orchestrate brain repair together this work will comprehensively dissect the biology of microglial states in brain repair and provide the enabling technologies to do the same in other contexts from development to disease it will open up microglial states to experimentation resulting in a step change in our understanding of this important brain cell type
ontologybased decentralized sharing of industry data in the european circular economy

circular economy aims at reducing value loss and avoiding waste by circulating materials or product parts before they become waste today lack of support for sharing data in a secure quality assured and automated way is one of the main obstacles that industry actors point to when creating new circular value networks together with using different terminologies and not having explicit definitions of the concepts that appear in data this makes it very difficult to create new ecosystems of actors in europe today this project will address the core challenges of making decentralized data and information understandable and usable for humans as well as machines the project will leverage open standards for semantic data interoperability in establishing a shared vocabulary ontology network for data documentation as well as a decentralized digital platform that enables collaboration in a secure and privacypreserving manner the project addresses a number of open research problems including the development of ontologies that need to model a wide range of different materials and products not only providing vertical interoperability but also horizontal interoperability for crossindustry value networks as well as transdisciplinary research on methods to find analyse and assess new circular value chain configurations opened up by considering resource information value and energy flows as an integral part of the same complex system three industry use cases from radically different industry domains act as drivers for the research and development activities as well as test beds and demonstrators for the crossindustry applicability of the results the developed solutions will allow for automation of planning management and execution of circular value networks at a european scale and beyond the project thereby supports acceleration of the digital and green transitions automating the discovery and formation of new collaborations in the circular economy