Dragon09/odtu_chatbot huggingface dataset:
offering combined hpv vaccination and hpv testbased cervical screening to vulnerable populations a hybrid efficacy and implementation study

hpvfasterimplement aims to improve cervical cancer cc prevention although human papillomavirus hpv vaccination and cc screening programmes have significantly reduced mortality they have reached a plateau because they remain largely inaccessible and underused by vulnerable populations creating inequalities in the european healthcare system this adds to the difficulties already faced by vulnerable populations in their efforts to maintain their mental and physical health hpvfasterimplement will create a europewide knowledge framework on vulnerabilities and the health challenges they pose as well as the tools to monitor their evolution hpvfasterimplement will work with stakeholder representatives primarily from vulnerable populations to identify contextspecific strategies to deliver combined hpv vaccines and hpvbased cc screening to eligible vulnerable populations thereby reducing the burden of cc in europe hpvfasterimplement will develop health education interventions communication activities and other services to meet the need of vulnerable population with high risk of cc and inadequate access to health services through stakeholder engagement health literacy promotion mathematical modelling implementation research and vulnerability mapping we will collect analyse and share knowledge on gaps and opportunities to improve cc prevention in europe and progress faster towards cc elimination we will work to ensure that the data we produce are translated into policy recommendations aimed at strengthening national prevention programmes with interventions tailored to vulnerable populations in this way we can leverage limited resources to rapidly reduce cc mortality we aim to reduce health inequalities by offering an innovative prevention intervention to women at risk with the hope that 50 of those offered the intervention will take it hpvfasterimplement will make the necessary improvements to european cc prevention policies
developing institutional open access publishing models to advance scholarly communication

in the transition towards open access oa institutional publishing is challenged by fragmentation and varying service quality visibility and sustainability to address this issue diamas gathers 23 organisations from 12 european countries wellversed in oa academic publishing and scholarly communication the project will1 map the current landscape of institutional publishing service providers ipsps in 25 countries of the era with special attention for ipsps that do not charge fees for publishing or reading this will yield a taxonomy of ipsps and an ipsp landscape report a basis for the rest of the project 2 coordinate and improve the efficiency and quality of ipsps by developing a european quality standard for institutional publishing eqsip this quality seal will professionalise strengthen and reduce the fragmentation of institutional publishing in europe eqsip will serve as a benchmark for a gap analysis of the data in 1 buyin and capacitybuilding is ensured by cocreation with the relevant ipsp communities of practice creating a common access point for ipsps an ipsp registry with 80 of ipsps in the era publishing guidelines training materials selfassessment tools financial models and shared cost frameworks diamas embraces diversity equity and inclusion by addressing gender equity in oa publishing and multilingualism in 15 european languages special attention is paid to building and enabling the financial sustainability of ipsps3 formulate communityled actionable recommendations and strategies for institutional leaders funderssponsorsdonors and policymakers in the european research area era workshops and targeted networking actions will reach and engage institutional decisionmakersin 36 months diamas will deliver an aligned highquality and sustainable institutional oa scholarly publication ecosystem for the era setting a new standard for oa publishing shared and codesigned with all stakeholders
flight demonstration of a liquid hydrogen loadbearing tank in an unmanned cargo platform

the flhying tank project aims to flighttest a 1000liter flightloadbearing vacuuminsulated composite lh2 tank in the pipistrel nuuva v300 cargo uav this project proposal is disruptive in several perspectives i definition of requirements design manufacturing and qualification of a relevantscale flightloadbearing fully composite liquid hydrogen tank ii accelerated acquisition of knowledge via flighttesting lowtrl hazardous technologies using uavs and iii effective application of the knowledge via calibration of a fluiddynamic thermal and structural digital twin of a composite lh2 tank using flight test data for advancement towards digitalized certification of aeronautical technologiesthe flhying tank project covers the disruptive maturation of lightweight liquid hydrogen storage systems via the accelerated acquisition of knowledge on flight operation of lh2 tanks as required by the demonstrator strategy of the clean aviation strategic research and innovation agendathe main impact of the flhying tank project is the unprecedented reduction in the timetomarket of revolutionary technologies in the aeronautical industry thanks to the groundbreaking fasttrack flight testing of a relevantscale composite lh2 storage system using a uav achieving comprehensive understanding of the behaviour of lh2 tanks in the flight environment within minimum timeframe risk and cost this ambitious goal can be achieved within the 1st phase of the clean aviation programme thanks to the flhying tank project
quality of life in oncology measuring what matters for cancer patients and survivors in europe

euonqol aims to develop pilot and validate the euonqolkit a patientdriven unified system for the assessment of quality of life qol based on evaluations and preferences of cancer patients and survivors the euonqolkit will be developed from a patient perspective administered digitally available in the eu27 and associated countries languages and applicable in future periodic surveys to contribute to the eus mission on cancer at the core of the euonqol there is the adoption of a multistakeholder codesign methodology engaging patient representatives healthcare professionals administrators policymakers and citizens in all project related activities existing qol tools will be reviewed scoping all relevant sources this review will be used in the context of the codesign consensus with stakeholders and patients preferences to identify gaps and establish all qol dimensions that are relevant from the perspectives of patients clinicians and society a multidisciplinary researcher panel composed by the most talented experts will develop the euonqolkit that will be validated in a pilot survey using digital data collection within month 24 of the project a total of 4000 cancer patients and survivors will be enrolled through a network of eu cancer centers an analysis of factors potentially impacting on cancer patients and survivors qol will also be performed implementation and exploitation strategies as well as the linkage with other cancer mission projects and actions will be explored to develop future periodic surveys euonqol is composed by research institutions cancer centers as well as scientific professional and patient representative organizations involved in cancer research all with extensive experience and robust scientific background in the development of selfreport qol measuresthis partnership fuels the ambition of euonqol to translate qol information into future changes in cancer care policy and clinical practice
cascades for stereoselective synthesis of amino acids

nonnatural amino acids are essential building blocks for pharmaceuticals the covid19 drug paxlovid is a prime example for this but as for most pharmaceuticals the synthesis of these amino acids is complex and requires many steps this is especially true for amino acids with 2 stereocenters the focus of this application of the group of the 20 most common natural amino acids 2 have not one but two chiral centers isoleucine and threonine nonnatural isomers of these 2 amino acids are surprisingly difficult to make and commercially not available via an economically viable process at the same time they are highly important for the production of drugs like paxlovid in cassaflow we will develop a cascade for the stereoselective synthesis of amino acids with 2 stereocenters based on the scalable breakthrough technology developed in our previous project oneflow we will design cascades of reactions shortening the current syntheses the main objective is to replace an 8step stereoselective synthesis of an amino acid with a 3step cascade to the same amino acid this will be achieved by installing 2 stereocenters in 1 biocatalytic step and by applying flow technology from the oneflow project here we will telescope long reaction paths with multiple work up steps into short and clean processes our innovative technology builds on oneflow methodology and will be combined with the reaction engineering and commercial expertise of the two smes in cassaflow chiralvision and spinchem the outcome of cassaflow will be a 3step trl 6 synthesis of an isoleucine that will replace the current 8step production and can be directly placed on the market importantly the cassaflow outcome will contribute to the eu strategic autonomy 20132023 plan that aims to achieve a greater independence from delivery chains and is in line with the pharmaceutical strategy for europe that aims to produce pharmaceuticals with short production chains in europe
steam learning ecologies

based on findings and lessons learnt from the implementation of previous open schooling projects the steam learning ecologies sles project will develop engaging open schoolingenabled science learning paths for all in learning continuums of formal and informal learning environments and enterprises by emphasising inclusiveness first the project will highlight the necessary conditions for bringing together all rather than some of the actors formal nonformal and informal education providers as well as enterprises and the civil society and giving all actors space and motivation to take initiative and central roles second by building on the promising results of previous work the project will propose a framework that generates opportunities for the creation of comprehensive partnerships in the form of interconnected knowledge ecosystems in local communities able to foster improved science education for all citizens and third it will initiate a concerted effort to make the evidence about the benefits of open schooling a driving force in european and national policymaking to achieve these the proposed project is introducing the powerful concept of learning ecologies as a vehicle for envisaging and realising impactful local open schooling partnerships as science learning continuums for all the project joins expert consortium partners and linked affiliated parties from 11 countries with individuals and organisations from all stakeholder communities to form diverse and widereaching steam learning ecologies together across europe
discovering the developmental transition of cortical parenchyma cells into different cell fates

the root cortex is a primary ground tissue of the root organ and plays an important and adaptive role in plant growth and function root cortical parenchyma thinwalled cells in the cortex have great potential to change both in structure and function during plant development even after cell differentiation root cortical cells can have many different postdifferentiation fates that form different cortical tissues eg aerenchyma exodermis in succession or even simultaneously through the deposition or degradation of lignin and suberin and programmed cell death the formation of these different cortical tissues have the potential to influence stress adaptation and plant performance for example by altering the radial movement of water and solutes the metabolic efficiency required for nutrient exploitation and the synthesis and deposition of exudatesi will investigate the developmental transition of cortical cells into different cell fates and the extent to which root cortical parenchyma have different cell fate trajectories to form simultaneous or successive cortical tissues i will discover the potential of tissues for synergistic interactions to capture soil resources and modify of rhizosphere properties and the genes that control these processes at a singlecell resolution to discover when and where signals occur in the cortex i will use a combination of breakthrough technologies and interdisciplinary expertise including stateoftheart imaging analytical chemistry microbial ecology and cuttingedge molecular biology methods to tackle the fundamental questions of how and why root cortical parenchyma have different postdifferentiation cell fatesfate will enable us to engineer crop roots to optimize soil foraging and resource capture the payoffs of this project will be significant for european agriculture as nutrient limitation is a primary constraint on crop growth and will become an increasing challenge due to climate change
mixed arrivals perceptions of threat inequality and the risk of violence between different forced migrant groups in north africa

host communities often perceive certain refugee or migrant groups as more threatening eg security or employment than others this can be seen from the recent arrivals of ukrainian refugees in europe but also in many other regions of the world in morocco for example subsaharan migrants are less favored than others unequal treatment by nationality ethnicity or time of arrival regarding status access to employment or residence is often the consequence yet little is known about what impact this has for intermigrant group relations how do forced migrant groups perceive other migrant group arrivals do they consider each other as potential rivals as to say as competitors or threats what factors increase or decrease intermigrant group rivalries and when might they turn violent or rather solidary mixedrivals applies a novel interdisciplinary approach by analyzing structural ex exclusionary policies as well as sociopsychological factors ex perceptions of threat positive contact and group identification bringing together theories on intergroup relations from migration violent conflict rivalry and psychology mixedrivals moves beyond the common hostmigrant focus and pushes the conceptual boundaries of rivalry refugeemigrant violencenonviolence liberalrestrictive policies further introducing the concept of mixed rivalries underlining the complex and multidimensional nature of possible contestations between migrant groups using a mixed method approach furnishing new crosssectional survey and qualitative data on intermigrant group perceptions of threat and inequality in four urban hubs in north africa as well as de facto forced migration policy data the project aims at advancing the understanding of intermigrant group relations at a time where north africa is becoming a major destination for mixed arrivals at the intersection between europe and subsaharan africa
marine systems approaches for biodiversity resilience and ecosystem sustainablity

marine biodiversity loss is continuing to decline despite current conservation efforts reversing the decline in biodiversity requires rapid roll out of effective conservation measures that can also enable a sustainable and resilient blue economy socialecological systemsthinking and ecosystembased management are globally recognized tools to enable balanced marine development and conservation marine sabres will codesign as simple social ecological systems approach the simple ses to rapidly enable and upscale ebm across europe and abroad marine sabres will set european marine management on a course to reverse biodiversity decline it will conserve and protect biodiversity by integrating sustainable ecosystems and a resilient blue economy enable managers to make sustainable decisions empower citizens to engage with marine biodiversity conservation promote sustainable development and in coastal and marine sectors marine sabres is comprised of an interdisciplinary consortium including world leaders in the field of ebm and social ecological system distributed across europe and focusing demonstration of practical management efforts in three demonstration areas tuscan archipelago the arctic northeast atlantic and macaronesia before upscaling throughout europe and beyond
a new labour law for supply chain capitalism

labour law gradually protects fewer of the worlds workers changes in work and capital structure new technologies and evolving modes of supply and production together supply chain capitalism lead to an incongruence between the distribution of market power and the premises and tools of labour law creating barriers to workers organization and agency this incongruence stems from the fact that labour law developed in industrial economies to respond to the power disparities between capital and labour and is therefore tied to a dyadic employeremployee paradigm in which labour law seeks to empower workers visvis employers the presumed owners of capital yet this is no longer the case in the era of supply chain capitalism where the direct employer is often a supplier in a global value chain gvc whose economic calculus is dependent on corporations in higher tiers of the chain given the crises of both labour law and gvc governance this project offers a path to restructure labour law to fit new patterns of supply chain capitalism the project includes three main components 1 theoretical the project intervenes in existing literature and theory on gvc governance and on labour law to propose a new analytical framework for reconceptualizing the role of workers and of labour law in gvc governance 2 empirical current initiatives to improve workers rights in gvcs worldwide are based mostly on voluntary schemes often perceived as private or rooted in softlaw the project will closely study existing initiatives and holistically analyse the studies development and examine whether and how labour law can be restructured to support existing successful initiatives and produce new sustainable paths to strengthen worker power in gvcs 3 normative based on the two preceding parts the project will create a blueprint for a new and overdue labour law for supply chain capitalism
nuclear shapes of heavy atoms and protonemitting nuclei

by combining atomic nuclear and particle physics techniques i shall perform the experimental study of the shape of key atomic nuclei to challenge our understanding of the nucleus this combined effort will reach unprecedented sensitivity precision and accuracy to determine the shape observables charge radii electric quadrupole moments and compare them to stateoftheart nuclear models spherical shell model density functional theory ab initio models based on chiral effective field theory this programme will combine different techniques at various accelerator facilities where i employ and develop unique approaches and instrumentation at cern isolde geneva ch highresolution laser resonance ionization spectroscopy will be performed with the resonant ionization laser ion source rilis combined with the perpendicularlyilluminated laser ion source and trap pilist to study the onset of octupole deformation and proceed towards the proton drip line with selected nuclei at ganil spiral2 caen fr highsensitivity laser resonance ionization spectroscopy will be performed in the supersonic gas jet of the gas cell at the focal plane of the super separator spectrometer s3 to study the most exotic isotopes not available at isolde reaching protonunbound nuclei at the drip line at psi villigen ch muonic xray spectroscopy will be performed on key isotopes to measure absolute charge radii that are crucial to complete the analysis of the nshape isotopes this work will combine a strong experimental development in target production for mux in the detector array and in the analysis toolscombining the highresolution laser spectroscopy and the highaccuracy from xray spectroscopy is a unique programme that only nshape can fully realize providing radii and moments with unprecedented accuracy from those results i shall obtain a deeper understanding of the strong interaction at work in the nuclear medium
advanced antigenspecific dendritic cellbased therapy to reestablish tolerance in immunemediated diseases

autoimmune diseases are currently treated with immunosuppressive and supportive therapies which dampen inflammation but do not stop the cause of the disease and are required lifelong thus there is an unmet need for safe and effective therapies for these diseases which are welltolerated and targeting the cause of disease tolerogenic dendritic dc cellbased therapies offer the possibility of restoring immune regulation leading to longlasting effects vitamin vitd3modified tolerogenic dc have been recently applied to multiple sclerosis ms patients in phase i trials demonstrating safety tolerability feasibility and preliminary evidence of an effect molecular characterization of vitd3dc from ms patients suggests that they own less tolerogenic properties than those from healthy individuals thus correcting these deficiencies through gene transfer could improve their effectiveness the aim of immutol is the fasttrack development and validation of an advanced therapeutic medicinal product atmp based on vitd3modified tolerogenic dc for immunotherapy approaches through a multidisciplinary approach immutol will leverage the power of tolerogenic vitd3dcbased immunotherapy to develop a more potent and durable treatment for ms and in turn other autoimmune inflammatory diseases with an unmet medical need in parallel it will bring information about tolerance mechanisms and patientspecific requirements for manufacturing effective toldc products results will lead to design of a clinical protocol according to the regulatory requirements for the firstinman application of engineered tolerogenic vitd3dc in ms patients
black sea floating offshore wind

lets harness the floating offshore wind energy potential of the black sea let the wind blowoffshore wind is currently one of the most costefficient clean and scalable power sources as of today offshore wind farms rest on bottomfixed foundations and are mainly deployed in shallow water areas with depths less than 50m floating offshore wind energy is expected to play a key role to materialise the vast potential of deepsea areasproject blow aims at unlocking the black sea floating offshore wind potential by demonstrating a disruptive costefficient floating integrative unit design optimised for low and medium wind speed areas blow will implement a 5 mw demonstrator in the black sea and will pave the way to industrial mass production and to the deployment of floating offshore wind farms in order to accelerate the energy transition in the region the project will couple synergies with the oil gas sector and foster societal acceptance and crossborder policy development blow targets an expected lcoe of 87mwh by 2028 and 50mwh beyond 2030 and an environmental impact reduced by 40