Dragon09/odtu_chatbot huggingface dataset:
highly efficient delamination technologies to recover and reuse metals glass polymers from endoflife photovoltaic panels

everpvs objective is to provide eu with efficient solutions for a sustainable treatment of endoflife pv panels and recovery of high purity and high integrity materials based on the grinding of pv panels waste from the backside andor the use of ir lamps heating everpv will demonstrate two innovative technologies to delaminate the different layers of the pv panel combined with recycling processes it will enable to recover glass with less than 1 impurities encapsulant and backsheet polymers with a purity over 99 and silver with a purity of 99 besides the project will cluster with other eufunded consortia already addressing the recycling of silicon eg photorama to provide with a global solution the new delamination technologies will be respectively demonstrated at envie recycling plant and at 9tech to reach trl7 the technology demonstrated during everpv project targets to process more than 3000 tons of solar panels per year thus recovering enough raw materials recovered to produce more than 350 000 new panels per year by 2030 everpv will finally demonstrate the potential for reusability of recovered materials in several industrial value chains in particular in the pv industry the project will lead a strategic analysis on the potential of new eol panels circular value chains based on estimated pv waste generation together with environmental and societal impact assessments everpv has gathered a consortium of 16 participants from 8 countries whose expertise ranges from solar pv materials and recycling processes cea csem enea tec recyclers envie 9tech process industries and materials suppliers sgb dtf dpl jbr pv modules manufacturing val collecting and waste treatment organizations soren erion policymaking business and training facilitators spe unitar bi
centre of excellence in aerosol remote rensing technology and science in the indian ocean

the overarching goal of realistic is to develop a centre of excellence in aerosol remote sensing technology and science in the indian ocean through the creation of a chair with la runion a european outermost region as a strategic pivot point of the european research area realistic aims at attracting and maintaining a highprofile researcher era chair holder to lead a high profile supporting team with excellent research and technical capabilities in the aerosol remote sensing domain in particular specific applications and research endeavours will be conducted in the area of quantifying the impact of wildfire and volcanic emissions on the tropical atmosphere composition and on the earthatmosphere radiative balance realistic is designed to catalyse and maximise the impact of the era chair in order to raise the research technical and innovation excellence of the laboratory of atmosphere and cyclones lacy the observatory of atmospheric physics of la runion opar the observatory of the universe sciences of la runion osur and the university of la runion ur to a level that makes them unique and essential references in the local ri ecosystem at the indian oceanlevel as well as to the overall international community and thus filling the ri gap on atmospheric systems realistic will contribute to better integrate ur within the european research area and better align with european standards and priorities
exposing the glial metabolism common link to brain damage

european population is rapidly aging while it was commonly believed that brain aging leads to neuronal loss recent studies found that instead the volume of white matter wm decreases and wm lesions develop with age wm degeneration is also a hallmark of multiple neurological disorders including alzheimers disease or multiple sclerosis understanding cellular responses to wm injury is therefore critical for design of regenerative therapies of central nervous system cns the european population is also increasingly overweight obesity is associated with higher risk of multiple sclerosis and other neurological diseases and leads to systemic lowgrade inflammation modulating functions of the immune cells while this paradigm has been extensively studied in peripheral tissues effect of diet on microglial states in cns is poorly understood i hypothesise that highfat diet disrupts metabolic response of microglia to wm injury and impairs regeneration my proposal aims to identify dietaltered microglial pathways and how to target them for promoting recovery after injury for this goal i will use the single cell and spatial transcriptomics to characterize in detail how wm injury and obesity alters cellular phenotypes however currently no method can link the metabolic state of the cell with its transcriptome i will establish method that combines metabolic measurements with single cell rnaseq in mouse models of highfat diet and demyelination in addition i propose to integrate spatial transcriptomics with electron microscopy as an innovative approach to visualize lipidloaded microglia and link their morphology to the transcriptomic state this project will provide critical new knowledge of mechanisms of wm repair the fellowship will allow me to become expert in applying and developing genomic technologies to devastating neurological disorders and deepen leadership and management skills to achieve my career goal of becoming independent investigator
pioneering automated building digitisation with lumoview for empowered decisionmaking in energyefficient building renovation

energyefficient building renovations are crucial for reducing the operational carbon emissions of eu building stock thereby aligning with the eus renovation wave strategy and carbonneutrality goal accurate comprehensive and uptodate data on the buildings structural and thermal aspects are required for effective energyefficient renovation planning which do not exist for most of the eu buildings further existing methods to collect such data are laborious slow and prone to human error especially for large buildings discouraging building owners and industry professionals from pursuing immediate improvements we have developed a patented easytouse handheld measurement device and proprietaryalgorithm to automatically digitise buildings interiors in record time with the eic we can accelerate the commercialisation of our enabling technology for industry professionals expediting buildings renovation process while significantly contributing to the eu renovation wave
repressit a novel class of clinical immune checkpoint inhibitors

in the tumor microenvironment continuous or tonic stimulation of t cells induces checkpoint signaling through inhibitory immune receptors irs this phenomenon suppresses t cell function contributing to an exhaustion phenotype and their consequent failure to eliminate cancer cells checkpoint blockade through irtargeting antibodies eg antipd1 antictla4 can partially reverse this process and has revolutionized cancer immunotherapy however a large fraction of patients eg with tumors that do not express ir ligands do not benefit from this treatment thus a large unmet need remains to be addressedwe aim to change the current ligandcentric blockade paradigm the repressit platform technology developed herein will provide a radically new approach through development of a novel class of ligandindependent checkpoint therapeutics these receptor inhibition by phosphatase recruitment ripr molecules recruit tyrosine phosphatases to the ir and shut down ir signaling thereby reactivating exhausted t or nk cells to effectively clear cancer cellsthe repressit consortium unites unique complementary expertise and models in ir biology tumor immunology protein engineering biophysics and proteomics to 1 define the design principles of ripr molecules against multiple checkpoint ir targets 2 evaluate the ir mode of action of signal inhibition 3 optimize ripr molecule for their efficacy using preclinical cancer models and 4 demonstrate in vivo proofofconcept poc focusing on a highlyrelevant panel of t and nk cell irs known to display tonic signalingrepressit will deliver a technology platform for offtheshelf ripr designs targeting phosphotyrosinecarrying ir this project will provide the foundation for our longterm vision of innovative immune checkpoint therapeutics with unprecedented efficacy and provide a greatly improved perspective to the many cancer patients for which current treatment is ineffective
data and metadata for advanced digitalization of manufacturing industrial lines

metafacturing focuses on a digitized toolchain for metal part production which will lead to a more resilient production process with respect to the raw materials used eg recycled materials reduces operator effort and cost and reduces scrap due to outofspecification parts the vision is to create a widelyapplicable digital twin based process setup and control framework fulfilling the requirements of industrial scale parts manufacturers with a specific focus on metal parts whose central hurdle is the effective use of available part and process data to improve the timetomarket and product quality this framework will strongly leverage on a range of stateoftheart technologies in the field of modelbased data fusion efficient process simulation and data standardisation and continuous life cycle assessment in order to efficiently develop solutions which are tailored for deployment in industry metafacturing project brings together 6 market leaders fronius nemak fill vitronic benteler and lth which will closely cooperate in order to reach a new level of leadership in sustainable manufacturing while maintaining their respective market dominance the envisaged approach will exploit all available data in the process starting from material data inprocess measurements endofline quality control and samplingbased product validation the digital twin based approach will enable the holistic consideration of this data in order to provide automatic feedback for the process control as well as providing novel metadata on the materials used which will be valuable to train the engineers working with these materials
egyptian cults in ancient thrace spread extent and interaction

the spread of egyptian isiac cults in ancient thrace was a multilayered and continuous process of great importance for the history of the balkans in fact it was a process that has lasted for more than eight centuries from the beginning of the hellenistic period end of the 4th bc to the end of the roman empire 4th century ad and it has probably left an imprint on religious beliefs of the local population originated from the nile valley drawing on the diverse religious concepts of ancient egypt the isiac cults have become weapon of central government throughout their long existence they were adopted very quickly by ordinary people because of the soteriological nature of the egyptian deities and the more personal connection they had with their followers that is why we find them all over the grecoroman world and in particular in ancient thrace where they were more or less assimilated with the local deities the project ecat egyptian cults in ancient thrace spread extent and interaction aims to give a comprehensive and modern study of the spread of the isiac cults in ancient thrace in order to expand our knowledge of religious beliefs in the southeast europe during the antiquity with one of the largest libraries of classical studies and open access to various research databases efa provides the best current academic context for the more interpretative and synthesising parts of the research by partaking in a more conceptual research culture this experience will have a decisive impact on my scientific development and will open up numerous new perspectives
solutions for critical raw materials a european expert network 3

based on the experience and background of scrreen1 and scrreen2 the prolongation of the project scrreen3 will continue to develop and animate an expert network which will contribute to expert advice in support of decisionmaking at the eu level covering all the raw materials and their value chains screened in the crms assessment
exploring the applications of picodroplet mass spectrometry

mass spectrometry ms is a widely applied analytical tool underpinning important commercial sectors like biotechnology pharmaceutics and environmental analysis a significant drawback is that the analysis is destructive resulting in irretrievable sample loss and making ms nonideal when sample is expensive or scarce we pioneered a technology capable of reducing the amount of sample consumed during ms by 4000 times compared to the existing stateoftheart by using picolitre 1012 l droplets because these sample volumes are so small our technology will significantly accelerate otherwise timeconsuming preparative chemistry benefitting end users in the abovementioned sectors anticipated commercial benefits include improved costeffectiveness and increased productivity gains arising from 999 cost savings on samples and substantial cost savings on staff time the commercial adoption of our technology will lead to new services and increased sales by enabling analysis of samples too scarce for current technologies the considerable reduction in sample consumption will provide environmental benefits and the capability to accelerate eg the drug discovery process may yield health benefits consequently our picodroplet ms technology has the potential to become the method of choice for a diverse range of ms end users to achieve these envisioned impacts we will develop relationships with key industrial stakeholders in the analytical instrumentation sector and building on our recent patent application advance our ipr strategy by evaluating market and licensee requirements we will engage directly with leading ms end users to quantify the benefits of our technology in the important application areas of reaction discovery biomolecular analysis and environmental sampling this poc will facilitate comprehensive evaluation of our technologys strengths relative to competitors and maximise its commercial potential
exoplanetary systems with a coronagraphic archive processing engine

determining the frequency of life in the universe is one of the main challenges of the next decades it requires a large highcontrast imager in space such as luvoir or habex able to characterize dozens of nearby earthlike planets the detection of such planets 1010 fainter than their star and lost in the bright and varying glare of the star in the images is a formidable challenge in the race to remove the contaminating starlight both the coronagraphic instrument and the image processing have a key role to play yet the science and technological definition of these mission concepts relies entirely on the coronagraphic instrument to reject the starlight assuming a simple gain of 10 in sensitivity with image processing based on 15yearold techniques developed for hst the cost of this approach is a daunting wavefront stability requirement of 20pm rms and conservative exoplanet yield estimateswith escape i propose to develop innovative image processing methods that make use of the specific hardware in these highcontrast imagers their wavefront sensors and deformable mirrors and of the data accumulated in their archives to bring a significant gain in starlight subtraction i will use the unique opportunity of the timely launch of the roman space telescope during the erc timeframe which precisely includes the cgi technology demonstrator of highcontrast imaging in space to demonstrate my methods and achieve 20x improved detection limits in parallel i will deploy the escape methods on the public archives of the vltsphere and jwst nircam and miri coronagraphic instruments to deliver highergrade data to the community obtain new planetary systems discoveries and constrain the giant planet population on scales yetunexplored and comparable to the solar system these ambitious goals and timeline will pave the way for the implementation of the escape methods in the future space imaging missions and facilitate the determination of the frequency of life
broaden research infrastructures deepen the geography of europe

the project bridge broaden research infrastructures deepen the geography of europe is aiming at organizing the celebrating of the the 20 years of esfri through a 20 years anniversary esfri cconference the cconference will take place in france under the aupices of the french presidency of the council of the european union on march 25th 2022 the heardquarters of the french academy of science at institut de france 23 quai de conti 75006 paris will be the main venue for this event the objectives of the project are the followingvalorisation of the impact of esfri on european ri system over the 20 yearsreinforcement of the role of esfri and the european ris in the renewed eraincreased awareness of the research and innovation actors of the opportunities provided by european ris
the formalist tradition in late scholastic philosophy a renaissance forerunner of formal ontology

in this uclouvainbased project claus a andersen will demonstrate the philosophical and historical importance of the formalist tradition in renaissance philosophy esp in the time span ca 14801620 the concepts of identity and distinction are the key components in the formalist treatises that enjoyed vast diffusion during the renaissance had roots in late medieval scholasticism esp in the works of the franciscan duns scotus and played a significant role in textbooks of scholastic philosophy in the 17th and 18th centuries the formalists discussed whether their doctrines constituted a discipline of its own a science of the formalities that would correspond to what today goes by the name of formal ontology the rise of a new metaphysical discipline needs to be part of what we know about the intellectual culture of the renaissance the formalist tradition has mainly been studied through its strains of influence upon other scholastic currents of the renaissance but has not itself attracted the attention it merits this project is innovative in its identification and elimination of this gap in our knowledge and in its focus on scholastic metaphysics during the renaissance the project will be supervised by prof jacob schmutz uclouvain it is conceived as a part of an endeavor to establish an internationally attractive milieu for studies in early modern scholastic philosophy at uclouvain and thus opens rich opportunities for future cooperation the applicant and the supervisor share a deep interest in the intellectual culture in early modern religious orders and will together curate an exhibition in the maurits sabbe library in leuven that documents the intellectual culture of the franciscans in early modern leuven on the background of the wider franciscan scholastic tradition the project further includes a practical training programme research articles an online catalogue of formalist literature and a conference with a proceedings publication
quantifying temporal patterns of viral mortality in soil

atmospheric co2 levels are affected by sources industrial processes respiration and sinks carbon fixation storage of organic carbon viruses that infect microorganisms may play an important role in soil carbon sink properties in soil carbon is stored or sequestered by binding to minerals recent studies show that longterm mineralassociated matter is mostly microbial debris and its fraction out of soil organic carbon varies by soil type hence viruses that break microbial host cells create microbial debris and contribute to carbon sequestration in soil yet are missing from carbon flux models we lack fundamental information about the physiology of soil viruses to link viral lysis of microbes and soil carbon sequestration recently we provided the first estimate of microbial mortality by viruses during soil rewetting after the dry season a peak time of carbon flux our study estimated mortality of up to 46 of cells within a week the main knowledge gaps preventing better accuracy of mortality estimates are the average number of viruses produced per host cell and infection rates yearround i propose to address these gaps using a combination of classic microbiology and cuttingedge bioinformatics this project will 1 generate physiological constraints for soil viral mortality across soil types with different amounts of microbial debris and 2 establish a multiyear monthly timeseries of viral infection dynamics of soil microorganisms i will focus on soil viruses infecting actinobacteriota an abundant phylum of droughtresilient soil bacteria that experiences consistently high viral infection rates a timeseries of viral activity will place the culturebased physiological parameters within the context of spatiotemporal dynamics of the entire viral community this project will create an unprecedented ability to estimate the potential contribution of viruses to soil carbon sequestration and incorporate it into global carbon flux models
brain fluids transport and clearance

scientific breakthroughs in neuroscience explain the need for sleep and the development of neurodegenerative diseases such as alzheimers and parkinsons diseases in terms of fluid dynamics the waste created during the day is cleared away as we sleep or it accumulates however a decade of research after the original theory was posed has revealed that the underlying physical mechanisms are still not understood and that the advanced mathematical tools are neededin this project we propose a research program addressing 1 new fluid dynamics mechanisms 2 novel numerical analysis for advanced multiphysics brain simulations and 3 a framework for patientspecific simulations we will exploit reduced order and machine learning methods in addition to finite element solutions withsuccessful delivery the acleanbrain will establish the main drivers of brain fluid dynamics provide a foundation for accurate efficient and robust algorithms for multiphysics problems and develop a software framework for advanced biomechanical brain simulations
fostering digital civics research and innovation in lisbon

while governments act as transactional providers of uniform and static services the challenges of contemporary society require different models of service design and delivery that are built on longterm engagement participation and cocreation with local communities and citizens digital civics posits the use of technology in the provision of relational models of public services by empowering citizens and nonstate actors to cocreate take an active role in shaping agendas making decisions about service provision and making such provisions sustainable and resilient dcitizens builds on those principles to achieve 5 main objectives o1 enhance iti research profile and innovation competence in digital civics o2 provide training to staff and early stage researchers to build critical mass at the interface of research local government and the privatethird sectors o3 establish a leading pole of excellence in digital civics o4 strengthen and expand the collaborative network between the twinning partners and o5 establish a digital civics research and innovation agenda in line with the smart specialization strategy for lisbon we identified four interconnected strategic areas in digital civics to be strengthened with the twinning partners support that provide solid ground to establish the methodology and action plan to reach these objectives the strategic areas are 1 communitybased research methods 2 emerging technologies 3 design justice and 4 civics policy and economic models based on these areas the projects work plan includes a staffexchange programme organisation of joint scientifictraining events activities to enhance the profile of young researchers training of research management staff and a small citizenled research project the consortium includes partners from one widening country iti portugal and three leading institutions in the field iit italy university of siegen germany and university of northumbria uk