Dragon09/odtu_chatbot huggingface dataset:
wasserstein flow learning for multiomics

single cell molecular profiling allows to map cellular development at an unprecedented level of detail optimal transport ot enables the analysis of this dynamical process as a trajectory inference problem using ot flows these flows treat cells as particles evolving on an energy landscape over an omics space such as transcriptomic epigenomic proteomic and location learning this model from large scale omics datasets poses however formidable mathematical and computational challenges which will be tackled by wolf the first one is the joint learning of both the gene embedding space and the energy landscape existing approaches use adhoc euclidean embeddings ignoring biological relationships between genes wolf will develop a new type of noneuclidean ot flows which takes into account complex genetic relations the second challenge is the fusion of multiple omics dataset for instance transcriptomics proteomic and space without having access to an explicit pairing between the cells across the omics multiomics is the next frontier in developmental analysis and the corresponding trajectories cannot be captured with existing ot flows wolf will develop a new class of multilinear ot flows where interaction terms couple particles together across different omics these advances will be integrated in an efficient computational package where the parameters of the models are learned using parallelizable ot flow solvers leveraging the connexion between ot flows and attention mechanisms in deep learning these methods will be approximated using transformers architectures and optimized using implicit differentiation these theoretical and numerical contributions will work hand in hand to offer the first comprehensive framework for multiomics trajectory inference this will unlock biological findings for the characterization of developmental molecular pathways and the understanding of disease mechanisms
artificial intelligence for institutionalised multimodal gamified mass democratic deliberations

democracy is facing challenges including loss of trust in eu institutions disillusionment and declining interest among citizens increasing political polarisation online disinformation and politically manipulated information and a growing distance between citizens and elected representatives we believe this can change if proper deliberative processes and tools are institutionalised that exploit the rapid advances in artificial intelligence and citizens postcovid competences we envision the next generation of digital deliberations as grounded on solid democracy theory multimodal video audio text usable and accessible gamified eg using skill points scoreboards missions and avatars mass enabled by novel but also legal and ethical ai features eg summarisation moderation fact checking hate speech and toxicity detection and easily adopted and institutionalized in this context the aim of ai4deliberation project is to provide robust ethical ai tools and comprehensive guidance to assist governments in institutionalising using and evaluating multimodal gamified mass deliberations the vision of the project is to equip governments with a theoretically solid and empirically tested set of aienabled deliberative processes a comprehensive framework with practical guidelines and an ai toolkit that will enable them to design institutionalise operate and evaluate transparent ethical inclusive multimodal gamified mass citizens deliberations resulting in more active and inclusive citizenship and increased trust to ruleoflaw based institutions by citizens to achieve these ambitious objectives the consortium brings together a team of world leaders in deliberative democracy ai and llms incl vidllms argumentation mining law and ethics deliberation platforms including videobased while four large scale pilots will be conducted from city level to international discussing topics that include climate change and long covid
specific grant agreement n1 to scale the cities mission platform

this sga provides comprehensive programming and support for the european commissions mission of 100 climateneutral and smart cities by 2030 it builds on the netzerocities nzc project coordinated by ckic combined these two projects set out actions as follows a create and operate a cities mission platform as a onestopshop to access the expertise capabilities services and solutions necessary to achieve climate neutrality this platform will provide tailored and intensive support to cities participating in the mission and will ensure open access to the knowledge and resources of the platform b help all mission cities with the cocreation and use of climate city contracts ccc to enable an ambitious pursuit of the goal of climate neutrality by 2030 this sga expressly seeks to ensure all mission cities are supported and builds directly on the initial scope of nzc in addition support will be offered to additional cities seeking to follow the mission closely c assist mission cities in the development of tailormade investment plans project preparation and finance for the cities participating in the mission d deliver substantial resources to mission cities for ongoing research and innovation activities critical to achieving climate neutrality by 2030 this support will be in the form of pilot funding to test and demonstrate actions needed to deliver climate neutral outcomes this pilot activity will work together with the platform and ccc processes in the cities operationalising emerging knowledge and insights about how cities can achieve the mission objectives
the building guilds of interwar europe an experiment in economic democracy

in the aftermath of the first world war european cities witnessed a massive expansion of producer cooperatives in the building sector drawing on ideas for industrial reform that were shared widely across borders these producer cooperatives or building guilds aimed to not only improve urban housing but also democratize the construction industries and society more broadly local cooperatives quickly merged into national associations that promoted distinct models of collective decisionmaking and shared ownership by the early 1920s paneuropean federations had started to distribute information and organize exchange between construction cooperatives that stretched the entire continent despite their rapid growth and initial success however the construction cooperatives of interwar europe have been virtually forgotten ecodem offers the first comprehensive historical analysis of this transnational movement focusing on england germany and spain the action has the following four objectives first it will reveal the democratization measures that were implemented to improve participation on the shop floor at the work site and in management second it will show what urban vision this trade union movement formulated and how this vision compares with the urban vision of architect planners and municipal officials which have received far more attention in scholarship third ecodem will investigate under what conditions employees accepted measures aiming at rationalization even if those measures had negative consequences for labor and fourth it will analyze the factors that determined success and failure of construction cooperatives in distinct national settings by studying a forgotten yet highly popular trade union movement ecodem not only advances scholarship in labor and urban history as well as the interdisciplinary scholarship on economic democracy but it also contributes to debates in the wider public about the future of work and urban housing
women tech eu grant application improving hearing aid exprience for hearing aid users

woid as consists of entrepreneurs mariel ellingsen the ceo and ivanna ustymenko the coo together they have broad knowledge and expertise regarding tech and business development woid as is a welfare and tech company compassion inclusion and social equality are our core values we must put people at the center of development to create value in society hearing aids are often paired with external microphones or speech enhancers for situations with a lot of background noise ormultiple speakers the company creates an application that digitalizes this assistive technology taking advantage of smartphones we remove excess devices while providing a satisfactory sound experience this is done by implementing cuttingedge technology for audio transfer while utilizing machine learning for noise reduction on commodity hardware this solution will become more economically and physically accessible than the ones offered on the market today
archives in times of war scattered families and vanishing past in contemporary syria

wartime syria questions conventional understandings of the archive as a physical repository of documents and set of institutional practices while syrian state archives have fallen victim to destruction and plundering syrians in the diaspora have been saving and retrieving copies of mundane legal documents originally stored in state repositories as these documents are official proof of legal identities education and relations to kin these papers are fundamental in any migratory project since they are needed for numerous procedures such as getting married these documents are also central in preserving a connection to family members in syria and in the diaspora archivwar examines these papers ubiquity so far undetected in the study of the syrian predicament and the dislocation of state archives in private repositories to rethink the concept of the archive as a form of care by examining family archives within the syrian diaspora in berlin the action first aims to capture the modes of care and the relations to affective and physical presences and absences stored in these documents second the project aims to make accessible a collective historyinthemaking about the syrian predicament in europe built upon the skills and experiences i have acquired along my research path the action combines ethnographic methods with oral history research while employing an innovative format of engaged public scholarship the project blends open science practices with immersive collaboration with the research participants to consolidate european societys scientific literacy on wartime syria and its longlasting effects in europe archivwar aims to contribute to the study of war and migration as well as of the archive and alternative forms of knowledge production but as well widen my knowledge and skills in the field of social anthropology migration studies curatorship and and open access practices to complete my maturation as an engaged social scientist
mission trajectory in atc and network management operations

the mitrano project validates the management of mission trajectories and civilmilitary cdm at network level and in atc operations including advanced design principles for the military access to airspace the dma of type 3 and provides a technological solution for aircraft surveillance data protection hence proving enhancement of civilmilitary cooperation and interoperability in atmfurthermore the validated solutions will contribute to the digital transformation of european atm by using as core of information exchange data sets created and disseminated automatically by technical systems hence supporting operators and decisionmakers to increase the efficiency of their activitiesnevertheless the project supports the implementation of a green single european sky by reducing the airspace segregations in the atm network hence enabling all categories of airspace users to fly more direct and efficient routes with a positive impact to the reduction of emissions the validation activities are organized within three solutions two operational and one technological cns related that ensure the development and validation of three overarching ri topicsmission trajectory in the atm network execution phase through associated network management and atc processesmission trajectory with dma of type 3security aspects for adsb automatic dependent surveillancebroadcast phase overlaythe key operational expected results reside in uptake from civil and military atm stakeholders of the mt validated concept and the associated network level civilmilitary cdm and on the dma type 3 concept furthermore adsb authentication layer and resilience to integrity attacks and the definition of a management system capable of distributing authentication keys to aircraft is a key expectationthe expected outcomes will bring performance benefits in the areas of airspace capacity environment operational eficiency civilmilitary coordination and security
inferring hominin population history through space and time using introgressed haplotypes

in the last decade ancient dna studies have increased their throughput from single samples to thousands of genomes published every year giving us unprecedented data about human genetic history however tools and methods that efficiently use this wealth of data are sorely lacking especially because dna extracted from fossils is often scarce and contaminated in this project i develop population genetic theory and bioinformatic methods that use ancient dna to refine estimates of when and where archaic and modern humans interbred to characterize the historical biological and functional consequences of this gene flow and to learn about the differences between modern humans neandertals and denisovans the first aim of this project is to develop a robust and general genotypelikelihood approach for local ancestry inference that allows efficient use of contaminated lowcoverage data and to establish approximate haplotypebased methods for inferring introgression tractsthe second aim of the project is to develop the necessary population genetic theory and statistical methods to translate the inferred haplotypes into biological insights the proposed theoretical numerical and simulationbased approaches will link the inferred introgression patterns with the underlying population genetic processesthe final aim is to apply these novel tools to study where and when gene flow between neandertals denisovans and modern humans occurred i also aim to identify introgressed haplotypes that are a target of natural selection and to quantify the relative importance of positive negative and balancing selection on neandertal and denisovan gene flow as a result this work will expand the tool set available for the analysis of ancient dna reveal the precise history of the interactions of neandertals and modern humans and provide answers to the key question of what genetic factors contributed to the survival of our species while all other hominins went extinct
second nature towards an informationprocessing theory of the reification of social reality

social reality is comprised of numerous social constructs such as institutions practices and norms these constructs are minddependent eg paper money is valuable because people believe it is research suggests that when people misconstrue social constructs to be mindindependent facts eg viewing inequality as a fact of nature they are less likely to question their legitimacy thus the attribution of mindindependence to social constructs or reification plays a critical role in governing human behavior despite the importance of this process we currently do not have a general scientific theory that explains reification across its varied instantiations eg the reification of nations economic systems mental ailments in the proposed project i aim to develop and test a domaingeneral informationprocessing theory of reification my pilot data suggest that there is both betweenindividual and withinindividual gradation in the extent to which constructs are reified i argue that in both cases reification may be a consequence of i dementalizing ie adopting a mindset and a discourse that does not consider mental states ii the mere passage of time and increased experience with the construct iii abstraction of knowledge in which the process of generating facts omits information concerning the human origins of constructs giving rise to erroneous inferences of naturalness these three processes may be causally related ie with increased experience constructs are abstracted leading to dementalizing however they also represent three standalone hypotheses which will be assessed across five workpackagesusing neuroimaging natural language processing methods longitudinal bigdata analyses and behavioral paradigms from experimental economics and memory research a better understanding of reification may help us devise interventions to dereify maladaptive states of affairs thereby addressing some of societys greatest ills
the pomxyz cluster in the bacterium myxococcus xanthus selfassembly translocation and fission of an active protein complex that guides cell division

in my research project i will theoretically model a fundamental process in the cell division of the model bacterium myxococcus xanthus namely the process for guiding the machinery for cell division to midcell in m xanthus a cluster comprised of the proteins pomx pomy pomz selfassembles on the nucleoid surface and in an atpconsuming reaction cycle translocates to midcell to guide the cell division machinery there during cell division the pom cluster undergoes fission and the resulting two pom clusters on the daughter cells again translocate to the respective midcell to induce further cell divisions i will consider a mesoscopic model which combines spatial dynamics with locally stimulated reactions to study the formation translocation and fission of the pom cluster my model is informed and will be further refined using experimental results of the group of lotte sgaardandersen at the mpi for terrestrial microbiology an established collaborator of my supervisor erwin frey i will quantify the constraints imposed on the proteinprotein and proteinnucleoid interactions by the tasks the pom cluster needs to fulfill selfassembly translocation fission and relate my mesoscopic model both to previously proposed heuristic models on pom cluster translocation and to stochastic reactiondiffusion models my project will lead to a deeper understanding of how biological systems actively create and maintain order my mesoscopic model combines spatial dynamics with locally stimulated reactions which are the two conceptual building blocks needed for spatial organization driven by energy consumption my model will therefore be applicable also in other instances of biological selforganization as well as in selfassembly of artificial nanostructures both of which are active and growing research directions my project will therefore make my research profile more impactful which will help me to reach my goal of becoming an independent group leader
localize and controlled codelivery of aunps conjugated sirna by cationic shearthinning gel matrix for treatment of arthritis desirta

arthritis is a common metabolic and immune associate disease that causes chronic pain and inflammation in a joint approximately312 million people are affected by arthritis globally it affects adults of all ages both sexes and all races and ethnicities but theprevalence in women is more than in men professional organizations have established many arthritis treatment regimens andmanagement guidelines in those nonsteroidal antiinflammatory drugs nsaids steroids and biologicals are the main ones these areeffective against the disease aggressiveness and pain up to some extent but the problem is this treatment is only symptomatic andrequires taking them lifelong in that case these drugs cause severe health problems and again increase the economic burden forthese reasons we need to develop a therapeutic technique and medication that can eliminate the symptom and causes of the diseaseforever and prevent the everincreasing number of patients worldwide desitra projects are an effort in the same vein to develop aneffective therapeutic alternative for arthritis that will avoid the aggravation of disease symptoms and cause of the disease togetherwithout causing any healthassociated side effects in this mainly gold nanoparticle aunps conjugated sirna will be delivered at thedisease site locally modified polysaccharides will increase the stability and release rate of aunpssirna and these assemblies will bedelivered very controlled and precisely through a synovial fluid mimicking the shearthinning hydrogel system the ambitiousproject will be conducted at two different groups and laboratories in ireland and portugal the project involves experiencedresearchers of other but related areas that will allow applicants to work in multidisciplinary aspects the prestigious fellowship willprovide a plate form of renowned subject experts and exposure to international collaborators will provide a unique opportunity togrow as a true researcher
smart public transport initiatives for climateneutral cities in europe

spines vision is to accelerate the progress towards climate neutrality by reinforcing pt systems through their smart integration with new mobility services sharing schemes active transport modes and micromomibilty spine adopts an equity centred design thinking approach leading the transition to a more efficient sustainable resilient and inclusive pt system a network of collaborative lls is developed to foster transferability while an intersectional view of the transport system users is applied four lead city lls in antwerp bologna tallin and las palmas will be established and a series of cocreation activities will take place where multiple stakeholders will be actively engaged in the development and demonstration of efficient replicable and socially acceptable innovative mobility solutions advancing existing assets the spine approach involves the creation of a innovative simulation and digital twining dt tools along with open data and behavioural models that will allow the building of scenarios combining different mobility interventions push and pull measures along with supporting policies and the implementation of the most promising ones b datadriven impact assessment models that will foster the twinning transferability and adaptation of the successful solutions of the four lls in seven twining cities barreiro valladolid zilina sibenik hrakleion gdynia and rouen spire sets a high ambitious plan for the codesign and implementation of 55 smart greens inclusive mobility solutions the spine consortium brings together a multidisciplinary team of 39 partners from 16 countries the unique mix of experienced transport engineers public transport operators computer scientists data analysts transport modelers social scientists urban planners policy analysts software providers within our consortium assures the comprehensive approach to the challenges scope expected impact and the successful delivery of the project