Dragon09/odtu_chatbot huggingface dataset:
investigation of phosphorus dynamics and microbial linkages for managed soil development

low pavailability in soils soil degradation overapplication of p fertiliser and gradual depletion of presources are a threat for the sustainability of future agricultural production within soils microorganisms play an active role in the cycling of p by 1 storing p within their biomass 2 mineralising nonplant available organic p and 3 solubilising inorganic p forms they are thus a key driver in the cycling of p in soil both in shortterm eg over a growing season and in longer term governing changes in soil p pools as soils develop greater insights in soil microorganisms role in cycling p in soil as a function of soil age properties and management would create new opportunities for developing more sustainableagricultural systems that make better use of p whilst simultaneously preventing losses to the environment in this project i will investigate the interactions between soil p soil microorganisms and soil characteristics that promote microbial p cycling and p availability to plants along a managed soil chronosequence industrial partner inden mine rwe power ag germany rwe the site represents a unique opportunity to study p dynamics under the effect of management practices and microbial processes over time i will use stateoftheart methods eg isotopic and spectromicroscopic techniques to deliver a better understanding of how soil microorganisms can regulate p availability in soil i will address the following scientific question how do soil properties management and time affect p dynamics driven by soil microorganisms i will carry out the research at the university of copenhagen denmark at the department of geosciences and natural resource management ign under the guidance of assoc prof carsten müller and i will undertake a secondment to with the group of plant nutrition at eth zürich switzerland under the supervision of dr federica tamburini
design of efficient catalytic nanomaterials as a pillar of a sustainable economy

the advcatalnanomat project covers one important topic the decarbonization of the energy sector as the core for a sustainable economy in this direction the synthesis of methanol and higher alcohols from co2 and renewable h2 is considered aiming to increase process efficiency in order to accelerate the deployment of co2 based technologies to achieve this the specific objectives of the project are i the design of new catalytic systems based on nonlayered 2d metal oxides through topochemical transformation using ultrathin layer double hydroxides ldh precursors ii optimize the reaction conditions through kinetic studies iii establish a relationship between structure and activity to achieve a better understanding of the nature of the active site and its reaction mechanism supported by mathematical models and theoretical studies and iv test and evaluate the performance of catalysts at semiindustrial scale bridging the gap from the laboratory to a pilot plant innovative materials with particular surface properties that relates to the coordination number of metal cations defect sites high surface area and high metal dispersion will be prepared targeting high alcohol selectivity c1c5 in the hydrogenation of co2 in this direction multifunctional catalysts containing cu for nondissociative co bond activation ni for dissociative co activation and co for cc coupling will be explored the success of this proposal lies in the interaction of several disciplines including material science the use of advanced spectroscopic characterization tools including synchrotron light radiation tools chemical engineering and theoretical simulation all these will support the proposed research and provide the necessary knowledge for the design of new catalysts it is a very ambitious project with significant scientific social and environmental impact contributing to strength the knowhow in the field of catalyst design and co2 valorization
eit rawmatrials business plan 20232025

metals and minerals are key enablers for the european green deal and will substitute fossil fuels in the long run at the same time europe is highly dependent on importing raw materials for its manufacturing industries and to accomplish the transition to a resource efficient sustainable society this is why the european green deal defines access to resources as a strategic security question for europes ambition to develop into a green economy to meet this challenge the vision of eit rawmaterials is to develop raw materials into a major strength for europe eit rawmaterials mission is to advance europes transition to sustainability by driving innovation along the entire raw materials value chain to fulfil the mission three strategic objectives are addressed securing raw materials supply designing materials solutions and closing materials loopseit rawmaterials is the worlds largest and leading partnership in raw materials and closely connected with the policy agenda of the european commission the knowledge and innovation community kic is open to new partners from regional innovation scheme ris countries and small business and is driven by a strategy that creates industrial symbiosis through innovation across value chains the european raw materials alliance erma managed by eit rawmaterials on behalf of the commission is an important mechanism for translating projects into investments and infrastructures that contribute to creating added value and jobs for europe within key strategic industrial ecosystems these initiatives are complemented by eit rawmaterials leading role in education and innovation activities such as the eits initiative in capacity building for higher education institutions hei and the european commissions european innovation area eia through these highimpact activities and the kics talent people and partner network eit rawmaterials has set the foundation to create impact and to achieve its strategic objectives
unobtrusive continuous multimetabolite monitoring for a physiological care of insulintreated diabetes

it will be a radically new approach for longterm continuous monitoring of insulintreated persons with diabetes itd moving from a glucoseonly to a multimetabolite monitoring glucose lactate and 3 ohbutyrate paradigm multimetabolite monitoring will also lead to a diabetes therapy breakthrough by algorithmically driving a continuous physiologic insulin delivery by a maintenancefree implanted mems pump using the peritoneal route enabling an optimal therapy for subjects with itdour vision is a fully implantable artificial organ to replace insulin secretion loss by targeting metabolic health instead of mere glucose control and mimicking physiological insulin action while offering a really burdenfree life for insulintreated children and adults it is expected to allow a dramatic reduction of metabolic variations hence a minimization of acute and longterm complications and an abating of the still high mortality of t1d patientsunobtrusive living with diabetes will be reached by the calibrationfree implantable longterm multimetabolite monitoring solution connected wirelessly to a novel highly miniaturized silicon mems micropump with down to 50 nl stroke volume able to operate a newly developed u1000 insulin and enabling reservoir refill cycles of 180 days up to 365 days both devices hold durable battery operating life of more than 8 years without recharge and are suitable for children newly designed control algorithms based upon multiple signal inputs will drive automated insulin delivery without the need of obtrusive meal and physical exercise announcements
chemical catalysis with piezoelectric materials

from the beginnings of the organic chemistry as a scientific discipline the main task has been clear how to perform organic reactions in an efficient and selective manner how to activate our starting materials without destroying them in the process catalysis such as redox catalysis can bring a solution to these questionsin the capele project we would like to harness the mechanical energy for activation of organic molecules piezoelectric materials upon impact undergo formation of separated electronhole pairs and can be used to initiate redox reactions in our preliminary experiments we have verified that extremely simple piezoelectric materials as sand quartz can be used as mechanocatalysts for redox reactionsthe main objective of this project is to discover new mechanoredox transformations i believe that development of new mechanoredox processes using cheap durable environmentallyfriendly and easily removable piezoelectric materials as catalysts can have real impact on the synthetic communitypiezoelectric materials can be used in this manner to perform a simple ez bond isomerization this simple reaction can be used to drive mechanicallyswitched molecular switches a discovery that has a huge potential impact on development of new mechanicallyactivated molecular devicesthis project requires an accurate method of theoretical prediction of redox potentials to enable rational reaction design of redox reactions we plan to develop such method using modern quantumchemical computational tools impact of such model is well beyond the scope of this project as it will give a powerful computational tool to the whole community of organic chemists involved in development of redox reactions i have extensive experience in development of catalytic redox processes computational chemistry mechanistic investigations and organic physical chemistry and therefore i believe that i am a perfect match to lead such an interdisciplinary project
evolution and merger of dynamical assembly black holes in agn disks

the growing list of binary black hole bbh mergers detected in gravitational waves gws by ligovirgo have been used to put tight constraints on einsteins theory of gravity however their astrophysical origin still remains a major open question recently active galactic nuclei agn disks have been suggested to be a promising location for forming bbh mergers in such environments black holes bhs either form in the disk or are captured through gasdrag from the surrounding nuclear star cluster exactly how the bhs pair up and eventually merge is likely a product of dynamical interactions taking place while the bhs migrate through the disk however no leading groups have so far been able to deliver a consistent description of this extremely important part as a marie curie fellow i will for the first time present a full numerical and analytical framework for describing the dynamical formation of bbh mergers in agndisks this will in particular include both postnewtonian pn corrections and gasfriction effects for describing the following key dynamical processes bhbh binary formation through gw emission and gasfriction bbhbh interactions both in the strong resonating and weak secular regime and the secular evolution of two andor more bhs in hierarchical configurations the goal of this study will be to provide the community with testable predictions that can be used to constrain this channel using gw data from ligovirgo especially including the distribution of bbh mass ratio bbh orbital eccentricity and bh spinorbit misalignment angles the project will be carried out at the niels bohr international academy nbia under the supervision of prof m pessah the interdisciplinary environment vibrant atmosphere and exceptional scientists make the nbia not only the ideal host for this project but further ensure that i will mature into a prominent scientist in my field during the time of the marie curie fellowship
respiratory precision medicine phd training network excellence through systems biology spatial and singlecell transcriptomics

asthma and copd are prevalent chronic respiratory diseases with high incidence and societal costs current treatment is based on a onesizefitsall approach that suppresses symptoms but fails to achieve stable remission of disease there is an urgent need to replace these generic treatments with precision medicine for asthma and copd this transition is hampered by the complexity of asthma and copd on the one hand and by the lack of an integrated multidisciplinary approach to achieve progress towards precision medicine for these chronic respiratory disorders on the other hand the complexity of asthma and copd is caused by multiple molecular mechanisms that independently contribute to the pathogenesis of disease their activity varies over time and between patients leading to substantial heterogeneity of asthma and copd identical clinical phenotypes can be caused by dissimilar molecular and cellular mechanisms and requiring different treatments the vision of respireexcel is to achieve the transition to precision medicine in asthma and copd by crosssectoral and multidisciplinary collaboration in respiratory research drug discovery and development the success of this approach depends on respiratory scientists with the competence to combine expertise across disciplines and the skills to collaborate with experts from industry healthcare and academia therefore the goal of respireexcel is to enable the transition to precision medicine for asthma and copd by training the next generation of translational and physician scientists with the skills crosssectoral competences and multidisciplinary knowledge to identify the molecular mechanisms of asthma and copd develop improved prognostic and diagnostic biomarkers to detect their activity in individual patients and support the development of novel treatments that target individual disease mechanisms aiming to achieve stable remission of disease in asthma and copd through precision medicine
autonomous spacecraft technology for repair operations lifespan improvement and flight testing

satellites are the backbone of our communication system with over 5500 satellites carrying signals across the world however once satellites reach orbit there is no way to inspect upgrade or repair them dorbit presents gea a disruptive spacecraft to be operated in geostationary orbit for inorbit servicing ios of commercial satellites the spacecraft will be equipped with a robotic arm with 7 degreesoffreedom and 3 mm accuracy gea also includes electric propulsion navigation and altitude control subsystems specifically designed to capture and maneuver customer satellites thanks to this innovation dorbit will provide diverse ios such as life extension and orbital relocation satellite operators will be able to extend the life of their satellites by up to 3 extra years 2550 of the current lifetime but the extension can go up to 7 years with gea achieving extra revenues with their existing assets of 20m per year we target to capture up to 25 of the serviceable 33 geo satellites with end of life in 20272030 for the initial service offering that would provide us with over 530 million in cumulative revenues by 2030 from ios nonetheless we are unable to fund this risky deeptech innovation from private investment in the current market landscape therefore we request this funding from the eic for the astrolift project in the form of 25m in grant and 15m in equity
cracking the posttranslational modification crosstalk code in s cerevisiae

posttranslational modifications ptms regulate all aspects of protein functionality dysregulation of ptms or the enzymes that regulate them is frequently associated with disease far from working in isolation ptms crosstalk with each other creating decisionmaking circuits that regulate the cellular adaptation to fluctuating environments ptm crosstalk is a regulatory layer of the proteome across the tree of life however to what extent and how ptm crosstalk regulates biological processes is a longstanding question in biology that is experimentally challenging to tackle the challenges lie in the natural complexity and infinite combinatorial possibilities of ptms and the lack of unbiased systematic methods to study their function we will use a combination of stateoftheart crisprbased editing methods to construct 30000 ptmmutants in all the proteins involved in the signallingtochromatin pathways and a scalable systems biology approach based on reverse genetics and chemical genomics to profile these mutants under 150 stress conditions mutants with similar phenotypic profiles are functionally associated allowing us to infer functional relationships for ptms regulators and conditions these functional associations will provide conditional regulatory ptm crosstalk events at an unprecedented scale we will further mechanistically dissect the function of selected ptm crosstalk events by interrogating protein activity cellular localization and interactions moreover we will dissect their directionality and modularity we expect these findings to be transferable to other eukaryotes due to the high degree of conservation in these core biological processes overall this project will revolutionise the ptm field providing groundbreaking insights into the functional understanding of ptm crosstalk and their regulation in s cerevisiae and unlocking the door for cracking the ptm code within and across biological processes
beam selfcleaning for spatiotemporal modelocked fiber lasers

mode locking ml is the most important technique to generate ultrashort laser pulses tremendous progress has been made in locking longitudinal modes in lasers with a single transverse mode eg singlemode fiber lasers spatiotemporal modelocking stml has been proposed by locking transverse and longitudinal modes in multimode fiber mmf lasers to generate ultrafast spatiotemporal pulses opening new directions in studies of nonlinear wave propagation thanks to fiber multimodality such lasers generate pulses with higher power with respect to their singlemode counterpart on the other hand the irregular beating among transverse modes is detrimental to achieving high beam quality this drawback can be overcome by kerr beam selfcleaning in gradedindex mmfs as pulse power grows above a certain threshold this process introduced by kerr nonlinearity allows for an irreversible transfer of power from the high order modes into the fundamental mode leading to a stable and robust bellshaped output transverse profile in this framework the beamlocker project aims at studying the dynamics of stml mmf lasers with highquality output beams by appropriate modeling the models will be established starting from preliminary experimental studies and they will be studied by analytical methods direct numerical simulations and numerical continuation and bifurcation methods in addition the noise behavior of stml lasers will be investigated in detail with a particular focus on the beam selfcleaning regimes the project results will stimulate further theoretical analysis and experiments on complex interactions in nonlinear multimode fiber systems furthermore understanding the complex properties of stml mmf lasers will shed new light on frontier physical phenomena such as spatiotemporal rogue waves generation and turbulence which find applications in several fields ranging from telecommunication to biomedicine
gender and intersectionality in the history of political thoughtthe cases of mary hays and george wallace

the overall goal of this research is to offer a novel account of the origins of protofeminist and antislavery ideas in british political thought based on hitherto overlooked writers and sourcespolitical philosophers have been long discussing the concepts of liberty equality and justice and political theorists are now rethinking urgent questions of gender and race yet there is still little conversation between them or investigation of how these notions have always been structured in response to one another the discipline of history of political thought is well placed to bridge this gap and to trace the intertwined development of these ideas as this research aims to showat the centre of this project stands mary hays 17591843 one of the first advocates of womens rights in britain hays it will be argued should be considered a major starting point of a tradition of european feminist freethought which championed radical prowomen antiracist and antislavery arguments and integrated them with new and nuanced conceptions of equality liberty and emancipation a second case study of this research is george wallace 17271805 who published the first essay in britain which explicitly advocated total and immediate abolition of both slavery and the slave trade 1760 wallace too offered an innovative and utopian account of equality and his categorical rejection of slavery entailed a historic shift in common interpretations of roman law natural law and the law of nationsamong the outputs of this research will be a monograph provisionally titled politics of freethinking religion gender and slavery in eighteenthcentury britain as well as a series of individual chapters and articles aimed at leading peerreviewed journals several academic and public activities will be held in collaboration with scholars of gender and critical race studies at jyvskyl to disseminate and communicate these findings
cooperative and intelligent unmanned aerial vehicles for emergency response applications

the climate change is now one of the biggest threats faced by our natural world and leads to many extreme weather events flooding wildfires and heatwaves unmanned aerial vehicles uavs are the promising technologies for the emergency response applications eras to provide more efficient and faster services to save lives and reduce economic loss this project aims to develop an innovative cooperative connected and intelligent uavs cius for eras where sensing and computing resources and flying information from individual uav could be shared and exploited through effective communications and control of the cius specifically contextaware and serviceoriented uavtoeverything u2x networks robust cooperative uav sensing and computing csc schemes and intelligent cooperative uav control strategies for eras will be investigated an international intersector and interdisciplinary consortium consisting of world leading academic institutions and prominent industrial partners is created to collaborate on developing novel ciu technologies in eras cuttingedge communications networks edge computing cooperative sensing intelligent control and machine learning related technologies will be investigated to tackle the associated challenges with competent and complementary expertise of the partners and their extensive international research collaboration experience this project will promote research innovation foster knowledge sharing enhance the potentials of participating researchers and contribute to the european leadership in the uavs cooperative sensing and computing multiagent control information and communications technology ict and emergency response sectors the developed ciu technologies and applications are not only applicable in various eras like flooding wildfires and earthquake but can also be readily extended to other applications such as smart cities public safety agriculture and the wider scientific community
to deliver the first medical treatment dedicated to patients with haemorrhagic stroke

the nanop2lysis platform is a deeptech technology to protect active enzymes by a reversible precipitation and to produce solidstate nanoparticles such particles can then be loaded at high concentration into tailored carrier with specific targeting slow delivery characteristics o2l001 derived from nanop2lysis is the first effective and safe treatment to remove intracerebral hematoma and reduce disability and death following acute hemorrhagic stroke ahs it has been tailored to be locally injected after microinvasive surgery via a catheter at the core of the hematoma the in vivo gelation of the product at body temperature allows a local and slow delivery of our new thrombolytic agent optpa the main characteristics of o2l001 are thus the followingeasy simplified model of administration unique injection efficient better thrombolytic effect on best translational model vs gold standardsafe reduced side effect bleeding and neurotoxoxicity vs gold standard