Dragon09/odtu_chatbot huggingface dataset:
antimicrobial nanostructured biomaterials for complex wound healing

complex wounds are a global health problem with significant impact on the health care economy in developed countries alone they impact the quality of life of more than 2 of total population complex wounds including chronic wounds or major burns are highly susceptible to microbial infection and biofilm formation and difficult to treat moreover silver is a widely used metal in antimicrobial products to treat wound infections however silverbased products are expensive and show several drawbacks due to costs as well as environmental and safety concernsthe nabiheal project will develop multifunctional biomaterials from proofofconcept trl 3 to the preclinical regulatory stage trl 5 to improve wound management the resulting biomaterials will enable affordable treatment of wound infections or prevention of complications during all phases of the wound healing processin the short and medium term nabiheal will develop at least two innovative multifunctional woundhealing biomaterials using affordable eubased manufacturing technologies in the long term nabiheal could become a gamechanging alternative to silver in woundhealing dressingsa consortium comprising 5 smes and 9 academic institutions with expertise in wound healing product development evaluation and commercialization nanotechnology safety and regulatory affairs will join forces to address these ambitious objectives
epromoters in health and disease

promoters and enhancers regulate transcription in higher eukaryotes the classical definition of enhancers is the property to activate gene expression distally while promoters induce local gene expression however itpromoters and enhancers regulate transcription in higher eukaryotes the classical definition of enhancers is the property to activate gene expression distally while promoters induce local gene expression however it was demonstrated that a subset of promoters termed epromoters also work as bona fide enhancers and regulate distal gene expression moreover it was shown that human single nucleotide polymorphisms snp within epromoters can influence their function and consequently distal and proximal gene expression of their target genes we hypothesise that epromoters might have an unanticipated key role in coordinating gene expression in disease as wellin this project i will develop a dual reporter assay to investigate the enhancer versus promoter function of candidate regions in order to identify novel epromoters subsequently selecting candidate epromoters predicted by a previously developed bioinformatics pipeline i will use the reporter assay to test the candidates in a highthroughput manner moreover i will select those validated epromoters that contain human disease associated snps using genomewide association studies databases next to determine which of these diseaseassociated snps have an impact on gene expression through epromoter function distally regulated genes will be inferred by genome editing of the identified snps in relevant cell linesconcluding i will study the biology of epromoters by i analysing their function in physiological context ii assessing the impact of overlapping genetic variants and iii determining the effect of diseaseassociated snps on epromoters and their target gene expression thus providing a valuable resource to understand epromoters and their potential involvement in different diseases
eliciting and exploiting procedural knowledge in industry 50

procedural knowledge pk is knowinghow to perform some tasks for industry workers pk is the knowledge required to carry out a specific job like correctly executing the safety procedure during maintenance interventions or configuring an industrial system by following the necessary steps in the right order or adopting practices and behaviours to optimise energy consumption in a plant the challenge in pk management is that this kind of knowledge may be hard to explain and describe oftentimes it is poorly digitalised and even when documented it may be still difficult to access and retrieve by industry operators the perks project supports the holistic governance of industrial pk in its entire life cycle from elicitation to management and from access to exploitation perks bases its solutions on ai both symbolic and subsymbolic and data technologies by advancing and integrating existing methodologies and tools in terms of readiness flexibility and user acceptance the results are applied and tested in three industrial scenarios white goods production plant computer numerical control machines microgrid testbed providing different use cases in terms of pk complexity and industrial requirements besides ai and data the third pillar of perks is people the goal is to satisfy the concrete needs of industry workers providing them with digital support to better and easier perform their tasks following a humanintheloop paradigm and putting them at the centre according to industry 50 approaches the outcomes of perks are a reference architecture for pk management a set of modular interoperable and complementary digital tools to be composed and customised to industrial requirements specific integrated solutions to solve the challenges of the project use cases a set of methodologies and best practices for broader application in other industrial settings paving the way for a wider transferability across contexts and sectors
reshaping supply chains for positive social impact

the aims of this proposal are to analyse social economic and environmental changes and disruptions including covid and evaluate their impact on scs identifying related challenges in terms of relationship between countries configuration of the network impact on employment to study and propose a set of sc models for the evolution of global sc integrating strategies like resource efficient closedloop and humanitarian as a way to increase eu resilience and sustainability particular attention will be given to the role of digitalization as a way to establish new paths for social inclusion taking into consideration the needs of urban and rural areas some important european sectors like fashion automotive medical and machine tools will be analysed with case studies and survey to develop innovative tools for monitoring and assessing sectoral trade patterns and defining mechanisms to evaluate relationship of disruptions like pandemic and global value chains taking into consideration impact on employment economic growth incomes etc also in the long term moreover it will be analysed the impact of different trade patterns on the eu value added of sectoral and countries with a specific focus on analyzing income inequalities and proposition of decent work and social cohesion particular attention will be gives to gender issues and social disparities to develop innovative policy scenarios with recommendations for future global value chains policy scenarios will be based on key horizontal issues impacting on several sectors and will provide recommendations for eu national and sectoral strategies policy measures and targeted actions aimed at shaping fair inclusive and sustainable trade patterns value and supply chains as well as production networks
ampher controller technology

uptake of electric vehicles evs depends on the availability of charging points if charging the evs is not possible people will stop buying them in some regions the available grid capacity is already setting limits to how many evs can be charged simultaneouslycurrent charging station controller technologies do not enable using the full available grid capacity as much as 23 of it may remain unused with such technologies the only solution to grid congestion is to increase grid capacity but this would cost billions and take decadesampher unique controller technology enables using the full available grid capacity and allows charging up to 6x more evs simultaneously with the same grid connection than current technologies this is achieved with breakthrough microcontroller and semiconductor technologies instead of high investments into infrastructurewith ampher controller all ev charging stations can be made smart and european climate goals can be achieved
diapausemediated cattle embryo storage

embryo transfer is a key enabling technology in the farming industry playing an essential role in expanding genetic improvement and its associated economic and environmental benefits the procedure requires estrous synchronized recipient animals which are often not available at the same time and location than the embryos the only solution available to circumvent this problem is to arrest embryo development by cryopreservation a technique that allows embryo storage but reduces embryo viability and requires time training and specialized equipment diapause is the natural way to temporarily arrest embryo development and it could provide an alternative means to store embryos before transfer in this project we will employ an advanced embryo culture system developed by the project stg757886elongan able to sustain embryo development beyond blastocyst hatching as a platform to test different media modifications to induce diapause in bovine embryos the development of a diapauseinducing medium will constitute a better solution than cryopreservation as it avoids the mechanical damage and exposure to cryoprotectants circumvents the need of special equipment and provides a faster and easier to learn protocol to store embryos
harnessing rubisco oxygenation reaction for advancing sustainable biotechnology

establishing a biobased economy requires the development of novel biorefineries where bacterial cell factories are employed for producing addedvalue compounds from cheap renewable substrates co2 is the ideal feedstock being the most abundant and virtually unlimited carbonsource on earth novel highly promising biorefineries aim to utilize genetically engineered bacteria to convert renewable energies and atmospheric co2 into fuels and chemicals the enzyme ribulose15bisphosphate carboxylaseoxygenase rubisco is the main responsible of co2 fixation in the biosphere via the calvinbensonbassham cycle despite its wide distribution in the tree of life rubisco is a rather inaccurate enzyme presenting a tendency to perform an oxygenation sidereaction which results in the formation of 2phosphoglycolate 2pg while reassimilation of 2pg in central metabolism results in net co2 loss it can serve as a precursor of glycolate an attractive versatile platform chemical here i propose to exploit the sloppiness of rubisco to implement a novel biorefinery for glycolate production from co2 ultimately i aim to demonstrate feasible microbial synthesis glycolate where engineered bacterial platforms synthesize this molecule directly from co2 as carbon source and renewable h2 or formate as energy source this overarching goal will be pursued through three different complementary objectives including in vivo screening of new recently described rubisco isoforms via ad hoc designed selection strain in vivo directed evolution of the best performing rubisco isoforms for improving the inherent oxygenation activity engineering of natural cupriavidus necator and synthetic escherichia coli bacteria autotrophs as cell factories for this process which will be tested in gascontrolled labscale reactors eventually such a novel biorefinery concept will open unprecedented possibilities for the use of co2 as feedstock for a true biobased economy
emission of marine microplastics by waves and wind a key mechanism for global microplastic dispersal

in this project i will focus on one of the most uncertain processes governing the worldwide spreading of plastic particles the oceantoatmosphere emission of microplastics mps i hypothesize that these marine emissions are significant at the global scale and contribute to dispersal of mps to remote ocean regions and back to land i propose an innovative and complementary approach to test this hypothesis based on three training research objectives tros including field observation and mps identification tro1 the goal is to collect and identify marineatmospheric mps from surface ocean and atmospheric marine boundary layer i will be trained for field sampling and mps identification methods experimentation tro2 the purpose will be parameterization of the watertoair transfer of mps via bubble bursting experiments i will be trained in laboratory experiments on bubble bursting mp emission modeling tro3 i will be trained for numerical oceanatmosphere modeling of mps emitted via sea spray and their atmospheric fate all these three tros will be addressed at the host institute cnrsget in toulouse and at uga and amu secondments in general this interdisciplinary approach combining field observations experimental work and modeling will enlarge our knowledge of the fate and global dispersal of mps constituting a threat in themselves but also as potential chemical and biological contaminants carrier and will thus contribute to the characterization of the human animal and plant exposomes
participative assistive aipowered tools for supporting trustworthy online activity of citizens and debunking disinformation

ai4deunk aims to develop 4 humancentered aipowered interfaces a web plugin a collaborative platform a smartphone app and an ar interface all these solutions will be built upon a debunking apito develop such an api ai4debunk will focus on 2 peculiar disinformation topics the war in ukraine and disinformation related to climate change by deeply analysing these case studies thanks to sociological experts targets groups sources way of diffusion we will map disinformation contents on knowledge graphs and compare them to existing databases thanks to ai methods such as nlp these knowledge graphs will be the skeleton of our technical work one will be multimodal meaning that all types of modalities written content image video will be directly embedded while the monomodal will be only about written content the different modalities will be previously embedded into written content then debunking modules will be developed for each type of modality based on ai and ml methods that could detect and examine questionable content by comparing it to the context extracted from the knowledge graphs rnn cnn multimodal language interpretation and transformers methods will be used to that extent the goal of such modules is to give a score of fakeness which we will call disinofscore for content given as input the api will then integrate this method and will be the bases of the 4 interfaces abovementioned the plugin will allow people to be instantly noticed when a content they are considering is fake or true the collaborative platform also called disinfopedia will allow more proactive online users to report questionable content that will be checked by a debunking committee chaired by a senior analyst the app interface will allow people to check content in their everyday life while the ar interface will allow citizens to have hindsight on the incoming generation of fake news and social media
pliocene hominin dispersal to southern africa choice or chance

modern humans are unique in their ability to adapt to and to thrive in different environments this trait facilitated their dispersal outofafrica to higher latitudes ie to temperate and seasonal habitats during the pleistocene however there are pliopleistocene hominins at higher latitudes in south africa sa from 37ma onwards did human behaviouralphysiological flexibility evolve early in our evolutionary history alternatively did pliocene hominins occupy such temperate zones due to different palaeoclimatic conditions in deep time andor due to stochastic events to untangle these questions this project will 1 determine the geomorphological and palaeoecological changes in the kalahariprotolimpopo basin 2 create dynamic palaeoprecipitationvegetation models from various archives 3 carry out detailed anatomical functional and morphometric analyses of the hominin fossil record and 4 combine the datasets to appraise species diversity functional adaptations geneflow hybridization and dispersal scenarios palaeobiogeography 3 key working hypotheses underlie the proposal 1 26ma east african ea hominin ranges expandedcontracted in accord with wet and dry phases periodically the southernmost populations became reproductively isolated early sa hominins represent descendants of australopithecus anamensis and australopithecus afarensis respectively 2 2615ma with the onset of the northern hemisphere glaciation and the reorganisation of the drainage pattern within the kalahari basin dispersal corridors repeatedly closed vicariance and opened resulting in intermittent levels of gene flow ie hybridization between ea and sa hominins3 15ma tectonic and hydrographic changes led to the zambezi river becoming a powerful barrier during the pleistocene sa hominins younger than 15ma are likely the result of endemism competitive exclusion amongst these hominins resulted in exploitation of distinct ecological niches
low regularity dynamics via decorated trees

low regularity dynamics are used for describing various physical and biological phenomena near criticality the low regularity comes from singular random noise or singular random initial value the first example is stochastic partial differential equations spdes used for describing random growing interfaces kpz equation and the dynamic of the euclidean quantum field theory stochastic quantization the second concerns dispersive pdes with random initial data which can be used for understanding wave turbulence a recent breakthrough is the resolution of a large class of singular spdes through the theory of regularity structures invented by martin hairer such resolution has been possible thanks to the help of decorated trees and their hopf algebras structures for organising different renormalisation procedures decorated trees are used for expanding solutions of these dynamics the aim of this project is to enlarge the scope of resolution given by decorated trees and their hopf algebraic structures one of the main ideas is to develop algebraic tools by the mean of algebraic deformations we want to see the hopf algebras used for spdes as deformation of those used in various fields such as numerical analysis and perturbative quantum field theory this is crucial to work in interaction with these various fields in order to get the best result for singular spdes and dispersive pdes we will focus on the following longterm objectives give a notion of existence and uniqueness of quasilinear and dispersive spdes derive a general framework for discrete singular spdes develop algebraic structures for singular spdes in connection with numerical analysis perturbative quantum field theory and rough paths use decorated trees for dispersive pdes with random initial data and derive systematically wave kinetic equations in wave turbulence develop a software platform for decorated trees and their hopf algebraic structures
the formal turn the emergence of formalism in twentiethcentury thought

the philosophy of science and logic underwent a wideranging formal turn in the first half of the twentieth century this shift is characterized by a new emphasis on formal methods and the adoption of a general formalist viewpoint towards the disciplines in question the project will give a first interdisciplinary and comparative study of early contributions to formalism in twentiethcentury thought this general objective will be addressed in terms of three interrelated subprojects the first subproject is historical in character and aims at a historical reconstruction of the emergence of formalist thinking in nineteenthcentury mathematics and neokantian epistemology on the mathematical side the project will retrace several methodological developments in geometry and algebra between 1860 and 1910 that contributed to a formalist conception of these fields regarding its philosophical roots the focus will be on contributions to a formalist notion of scientific objectivity in the work of the marburg school of neokantianism hermann cohen ernst cassirer paul natorp the second subproject will give a comparative study of the formal turn in logic and logical empiricism between 1920 and 1940 this includes research on the foundations of mathematics and the formality of logic by members of the göttingen school david hilbert paul bernays gerhard gentzen as well as central contributions to a scientific formalism in logical empiricism rudolf carnap moritz schlick the third subproject will analyze the philosophical implications of the formal turn for the subsequent shaping of these fields the emergence of formalist thinking was closely related to the development of new theories of semantics in logic and philosophy the aim will therefore be to connect the early contributions to formalism with contemporary debates on the philosophy of model theory and inferentialism as well as with the logical study of scientific theories
deciphering intents of air traffic controllers workload assessment and gaze analysis to enable their efficient and trustworthy collaboration with ai

the dialog project aims to improve collaboration between air traffic controllers atcos and artificial intelligence ai systems in air traffic management it addresses a very ambitious goal of enabling ai members of humanai teams to anticipate when and what kind of assistance their human teammates need and to respond on that dialog will develop an aibased digital assistant called teamwork assistant that uses speech recognition and understanding of pilotcontroller exchanges to infer atcos intent and goals it also utilizes machine learningbased methods to assess atcos workload and attention in realtime based on voice physiology and behavioral data the actions of the digital assistant are determined based on the atcos current state attention allocation traffic situation and general context the project will develop prototypes and conduct validation exercises in close collaboration with endusers to assess the performance and usability of the proposed solutions
microorc orchestrating food system microbiomes to minimize food waste

the microorc project aims to provide business innovations for monitoring and orchestrating the microbiome and by that reduce the amount of avoidable food waste by developing tools technologies services and guidelines for i improved food process control accurate shelf life prediction and dynamic date labelling and ii extension of shelf life by bioprotection and packaging technologies that control the growth of spoilage or pathogenic organisms five areas are selected for the potential for predicting and extending shelf life reduction in food waste and fostering a sustainable food system predictive analytics models incorporating microbiome information to predict shelf life timetemperature indicators ttis sensoring and smart label solutions for dynamic shelf life labelling rapid detection assays for microbial indicators of food spoilage microbiome based protection technologies to replace synthetic chemicals and increase shelf life and safety novel packaging solutions targeting spoilage for sustainable development and increased shelf lifemicroorc will support the transition to more sustainable and healthy food systems by considering raw chicken and salmon as well as plantbased meat analogues to guide and demonstrate the industrial social and economic relevance of the microorc innovations the project will evaluate consumer acceptance and the environmental sustainability aspects of all stages of the product life cycle identify and help resolve legislative and regulatory challenges to implementation of new technologies and propose a novel policy framework for microbiome control in the food system a multinational multiactor and transdisciplinary consortium including cuttingedge companies and experienced research institutions has been established to develop and pilot tools technologies and guidelines that utilize and control microbiomes for fighting food waste to ensure transition to more sustainable food production and consumption