Dragon09/odtu_chatbot huggingface dataset:
spatiotemporal dynamics of secondary metabolism in the ocean microbiome

microbial secondary metabolism sm is critical to ecological interactions because it is a source of bioactive products such as antibiotics and anticancer drugs marine microbes are prolific sources of these compounds until now the prospection of biosynthetic gene clusters has primarily focused on cataloguing sm diversity by using machine learning ml tools with little regard to their importance for the microbial dynamics microbes benefit from sm by providing a chemical language for interspecific communication and improving environmental interaction the dynamics and evolutionary aspects of this interaction as well as its effects on spatiotemporal microbial dynamics have not been studied due to a lack of suitable datasets to elucidate this the spadynsm project aims to investigate the spatiotemporal dynamics of sm in the ocean microbiome using an innovative genomeresolved work frame to verify diversity mutations selection pressures and effects on environmental variables in a collection of metagenomes from monthly marine samples collected by the host and collaborators over a 7years period dr santos will combine his unique expertise in biochemistry molecular biology bioinformatics and ml with the hosts notorious experience in microbial ecology and evolution to document the fluctuation of sm in marine microbes for the first time on an unprecedented temporal scale spadynsm could lead to a better understanding of seasonal patterns of sm in marine microbes environmental effects and possible impacts on microbial evolution spadynsm continues to advocate for the analysis of polymorphisms at the protein structure level which may lead to the discovery of novel druglike compounds this highly interdisciplinary project with its international collaborative network and innovation will advance the eus research and policy strategies such as biotechnology and microbial community modeling fields and will boost dr santos promising carreer
satellitebased services to support sustainable land use practices under the european green deal

the main objective of greeneo is to provide improved satellitebased environmental information to support sustainable nature protection practices across four competing landuse areas cities agricultural areas forests and ecosystems through combined exploitation of new earth observation products digital infrastructure and atmospheric and land surface models using machine learning and data assimilation greeneo will provide environmental information and stakeholder engagement practices to support the implementation of the zero pollution zp and biodiversity aspects of the european green deal egd the project will serve as a proofofconcept to enhance specific services provided by copernicus and eumetsat in support of the egd implementation greeneo aims to support the transition towards more sustainable land use practices in europe and proposes a transformative governance system relying on a data value chain enhanced with active stakeholder engagement and cocreation the value chain proposes the uptake of satellite data integrated in a modelling development chain and followed by value creation modelling applications in cities greeneo will develop three satellitebased approaches of highresolution urbanscale air quality maps to engage relevant stakeholders to support the zp strategies for agriculture greeneo will address impacts on nitrogen emissions deposition and biodiversity it will create satellitebased highresolution emission inventories deposition critical load exceedance maps and identify areas with high recovery potential greeneo will develop a forest fire service that will revolutionize the monitoring of wildfires over europe greeneo will create novel ecosystem monitoring indicators such as city greening indicators ecosystem area and condition indicators greeneo will advance seamless climateweather and environmental services in europe by proactive links to eumetsat wmo the copernicus services eea and eu missions
deciphering hostgut microbiota spatiofunctional plasticity in inflammation

over the past two decades gut bacteria have emerged as major regulators of human health the focus in the field thus far has been on bacterial taxonomy with their spatial organization and functionality largely overlooked crohns disease cd vividly portrays this spatiofunctional dimension as it features patches of gut inflammation skip lesions surrounded by uninflamed regionsin the same hostwith a clear demarcation but unknown cause our preliminary data demonstrate hostmicrobe functional feedback loops in which bacterial strains can adapt and modify their immunomodulatory functions in response to the host moreover we find functional alterations in gut bacteria of ibd patients thus we hypothesize that bacterial spatiofunctionality can be largely affected by host physiology and in turn modulate the pathophysiological state creating a functional feedback loopwe propose to study bacterial spatiofunctional plasticity and mechanisms of hostmicrobe interactions in cd and their potential causal effects on inflammation combining microbiology immunology and systems biology approaches we intend to focus on three independent yet complementary aims 1 characterize hostmicrobe spatiofunctional alterations in skip lesions and assess their potential causal effects on inflammation 2 decipher the functional and molecular mechanisms of hostmicrobe feedback loops in healthy and inflamed intestines and 3 develop a toolbox for highresolution functional analyses of gut bacteria directly in their natural environmentsthis study will address for the first time bacterial functional plasticity in response to host inflammation unveiling the phenomena its mechanism of action and potential causal effects on gut inflammation such understanding can shift our perception on microbiotahost interactions may explain contradictions in the field point to novel contributing factors to cd and related disorders and guide future translational studies
advanced technological solutions coupled with societaloriented understanding and awareness for disrupting trafficking in human beings

vanguard aims to strengthen the fight against trafficking in human beings thb at the nexus of advanced technological solutions understanding awareness raising and training in order to disrupt the trafficking chain at an early stage and address the culture of impunity in particular vanguard aims to provide an improved intelligence picture of thb with particular focus on thb for purposes of sexual exploitation labour exploitation and forced criminality this will be achieved through developing a modular and trustworthy suite of tools for detecting identifying investigating and preventing onlinefacilitated thb activities and thbrelated activities at border checkpoints based on the analysis of online multimedia content and multimodal streams by leveraging the latest advancements in artificial intelligence ai it will also address the societal dimensions of thb through improved understanding and engagement with relevant actors improved strategies of international cooperation increased awareness and better evidencebased policymaking the capacity of end users including police and border guard authorities will be further enhanced and will enable them to tackle such criminal activities in an effective manner based on advanced tools and solutions and on innovative training curricula vanguard will be validated in field tests and demonstrations in three operational use cases extensive training handson experience joint exercises and training material will boost the uptake of vanguard tools and technologies with a consortium of seven police and border guard authorities including from countries of origin and transit of thb networks and countries neighbouring ukraine one police academy eight researchacademic institutions four industry partners including two smes and two csos vanguard delivers a strong representation of the challenges requirements and tools to meet its objectives
upcycling mineral and timberbased waste from construction manufacturing process industries through ecodesign advanced logistics quality control and digital solutions

the transformation of the european process industry needs to embrace circular economy and restorative feedback loops as a key pillar of the design of entire value chains construction as a wasteintensive sector is expected to greatly benefit from the potential impacts of circular economy models to optimize the use of resources reduce exploitation of raw materials and costs associated with its supply in the construction and manufacturing process industries a key challenge to allow the actual uptake of circular economy models and of upcycled repurposed andor recycled materials lies on the need to guarantee that reclaimed materials can offer the same level of quality performance and safety of new secondary products the aim of circuless is to contribute to foster circularity in the construction and manufacturing process industries by minimizing construction and demolition waste cdw as well as manufacturing waste cdm with focus on mineral ie concrete and timberbased material streams which is aligned with the objectives of the processes4planet partnership by developing new processes for circularity of secondary materials from wastesresidues for all industrial processes without compromising quality and performance as well as sustainablebydesign circular products circuless main objective will be addressed by experimenting new circular products and novel processing techniques to improve the quality and performances of secondary materials up to industry expected standards improve value chain environmental friendliness maximize recycled components these actions will benefit from the support and will provide inputs to a tailored digital platform to orient decision making and operational activities finally to foster uptake by the construction sector recommendations for standards updates and relevant training material for both upskilling current construction workforce and create new specialized profiles in the sector will be created
the social life of ancient dna how can scientists and citizens better interpret the past in light of ancient dna research a dual ethnographic study in germany and vanuatu

more than ever before humans have access to new specialist knowledge involving genetics eg ancestry genomics social epigenomics crucial questions are at stakes as this newly accessible knowledge grants individuals with an objectifying image of their identity knowing the real or potential biological endowment of oneself others has tremendous social political ethical consequences this project extends my investigation of practices whereby genetics the construction of identities intersect in a field little studied by ssh sts ancient dna adna research at the crossroads of archaeology bioanthropology population genetics adna research entered a golden age in its contribution to untold facts on past societies the way it changes how past populations are perceived while this field is growing rapidly indepth understanding of social political consequences arising from practices knowledge produced are crucially needed we still lack robust ethnographic understanding of how adna researchers incorporate the knowledge they produce into narratives about origins ancestry social relationships meanwhile little is known about what exactly citizens or community stakeholders cs do with genomic histories they receive from adna researchers the main goal is to study how scientists cs interpret the past in light of this new knowledge this project involves two research sites researchers producing adna knowledge in an unprecedented casestudy located in a leading research facility in germany the postcolonial context of vanuatu where knowledge produced from ancient remains raises significant issues for css ancestry narratives studying the production circulation of adna knowledge in interaction between identity from an ethnographic perspective is not only highly original greatly needed but timely this project is utterly innovative invents new collaborations involves fields that spans across social natural sciences
the interplay of neural networks enabling social interaction

the quality and number of social interactions are among the best predictors of longterm health so how do good social interactions arise social neuroscience has focused on a number of affective and cognitive functions as potential building blocks of social interaction however utilizing mainly simplistic and passive paradigms we still fail at describing how actual live social interactions emerge and why they so often go awry especially in people with mental disorders here the concept of building blocks may have become an impediment to progress recent evidence suggests that in more complex experimental tasks socioaffective and cognitive processes are not simply stacked up but are dynamically working together just as the underlying neural networks seem to engage in lively interplay interacts main objective is to understand how adaptive social interactions emerge based on elucidating the interactions of networks and processes interact will take a major leap forward with a systematic and mechanistic yet fully sociallyinteractive approach across six work packages interact will move from the comprehensive investigation of behavioral and neural interaction patterns of social affect and cognition in controlled lab settings to completely free social interactions in peoples everyday lives combining a novel experimental approach with dual neuroimaging hyperscanning and multisite neurostimulation neuroeconomics and multiagent ecological ambulatory assessment interact will shift from a modular to a complex systems study of actual social interaction it also provides steps towards specific and targeted interventions in people with social interaction difficulties interact aspires to bridge the gap between basic and applied research developing an interdisciplinary model of social interactions that expands our knowledge and applies it to realworld settings
sesar3 atm master planning and monitoring

the master planning and monitoring project so called ample3 is to support the sesar3 joint undertaking s3ju in planning and reporting on deployment activities in deployment covering both industrialisation and implementation and when need be to contribute to the update the european atm mp the project provides content integration ci service to s3ju in support of the development activities and the delivery of a coherent set of sesar solutions aligned at content level with the s3ju mawp direction and ambitions declined from the european atm mpwhile earlier sesar programmes addressed phases a b and c of the sesar vision the sesar 3 ju multi annual work programme mawp presents the strategic research and innovation ri roadmaps of the digital european sky des programme to achieve also phase d of the sesar vision the mawp identified several transversal activities ta to make the des programme not just a list of disconnected projects but a coherent programme supporting delivery of sesar solutions
mobilise a novel and green mobile one health laboratory for reemerging infectious disease outbreaks

mobile laboratories are becoming increasingly important for quick response to epidemic outbreaks in remote areas due to climate change and rising temperatures emerging arboviruses crimeancongo haemorrhagic fever virus west nile virus rift valley fever dengue fever are finding their way into europe through arthropod vectors mosquitoes ticks and are becoming a major public health concern optimally monitoring zoonotic outbreaks requires a one health approach in which not only human but also animal and environmental samples are analysed as close as possible to the vectors habitat also returning travellers might carry haemorrhagic ebolamarburg virus or respiratory pathogens such as sarscov2 a survey of existing european mobile laboratory capacity revealed several shortcomings of 193 labs 66 were civilian 88 were exclusively for human diagnostics with 11 having an accredited quality management system and only 3 had the highest biosafety level bsl4 needed for haemorrhagic arbovirus handlingmobilise aims to close this diagnostic gap by developing a novel qualityassured mobile one health laboratory solution to provide bsl4 capacity to many european countries it will receive humananimalenvironmental samples for molecular diagnostics serology microbiology and host a whole genome sequencing platform for pathogen discovery and epidemiological analysis we will further develop novel rapid diagnostic tests for bsl34 pathogens and produce results in machinereadable form a novel aibased emergency operating centre and decision support system software will assist endusers in coordinating mobilise fleets across europe and manage outbreaks in realtime hosted on an electrichybrid truck platform and using solar and windenergy it will also reduce co2 emissions in compliance with the european green deal the lab will be fieldtested to trl7 by national agencies and firstresponders in austria romania greece and africa
prefiguring democratic futures cultural and theoretical responses to the crisis of political imagination

democracy is in a crisis of global scale this crisis has variously been attributed to a loss of belief in political representation the rising of technocratic postdemocracy or an authoritarian and populist turn however a narrow focus on the political system is inadequate predef starts from the assumption that the crisis of democracy is also a crisis of political imagination as the infamous tinaprinciple there is no alternative illustrates it has become increasingly difficult to imagine genuine democratic alternatives to the status quo predef sets out to explore potentials for deepening and pluralizing democracy beyond the sphere of politics narrowly defined as the body of existing political institutions the project will turn to the fields of culture art and intellectual history for these fields hold hitherto untapped potentials for extending our democratic imaginary and disclosing political alternatives located at the intersection between cultural research and democratic theory predef meets this challenge empirically and theoretically empirically artistic and cultural counterpractices are investigated that champion democratization in the timebased arts through theatrical occupations international relations through countersummits and law through mock tribunals theoretically the project seeks to widen our democratic imaginary by searching the history of ideas for forgotten institutions that hold untapped democratic potentials and by elaborating a democratic theory of counterinstitutions the main objectives are iregaining a sense of possibility in a time of vanishing democratic alternativesiiexploring the democratizing potential of cultural and artistic practices and institutionsiiilearning from alternative configurations of the past and beyond the western context specifically regarding institutional designsivconnecting theoretical and empirical research with the aim of genuine crossfertilization
for tunable thermochemical energy storage

to accelerate the energy transition there is an urgent need for energy storage both for electricity and heat due to the intermittency of renewable resources as a large part of our energy consumption is in form of thermal energy 78 in the built environment and as there is a large amount of unused low temperature waste heat 8900 pj in europe thermal energy storage offers route towards bridging availability and demand long term lossfree compact heat storage is the missing link and thermochemical energy storage tces has the potential to play this role unfortunately present tces concepts lack flexibility as a precise fit between the phase diagram of tcesmaterials the system design and the temperature demand of an application is needed therefore most of the rd for applying tces is very specific for a particular application and switching to another application requires that much of the rd process has to be redone 4tunates will deliver a groundbreaking flexible tces technology that can be easily adapted to different applications variable in and output temperatures and thereby reduce the development costs by 90 as the rd the process does not have be redone repeatedly 4tunates develops a tcesprototype that can be used for domestic use cases which addresses three challenges 1 radically new tces materials with tunable phase diagrams by using a second gas or dopants 2 heat exchanging components with a high degree of manufacturing flexibility and 3 revolutionary systems with electricity adapted thermodynamic cycles cnr and dlr will integrate the key findings in their hightrl project portfolio and cellcius cel will integrate the successful materials and designs in their technology this will unlock the potential thermal energy storage for this purpose a strong consortium has been built which brings together computational material scientists vub physicalchemists tue ciiae mechanical engineers cnr dlr and heat battery developer cel
discovering how t6ss effectors are deployed in the recipient cytoplasm

interbacterial competition is a key driver of the emergence of new bacterial strains a widely used strategy during interbacterial competition is delivering toxins into competitors cytoplasm where they target conserved components the type vi secretion system t6ss a machine that delivers toxic effectors into neighboring cells is a major player in interbacterial competitions it fires an effectorloaded tube that penetrates the recipient cell envelope although many t6ss effectors target the competitors cytoplasm it is not known whether they are directly deployed there or rather deployed in the periplasm and then transported into the cytoplasm we have recently identified several domains within modular t6ss effectors that are fused specifically to cytoplasmtargeting toxic domains the new domains are required for competitor intoxication during competition but not for t6ssmediated secretion of the effectors therefore we hypothesize that t6ss effectors are first deployed in the periplasm where specialized domains such as these relocalize cytoplasmtargeting effectors into the recipients cytoplasm in imcross we will leverage our unique expertise in identifying and characterizing novel domains within effectors to go beyond the stateoftheart and determine how cytoplasmtargeting t6ss effectors reach their target we will 1 reveal the initial site of t6ss effector deployment 2 identify effector domains responsible for transport across the recipient inner membrane and determine whether they employ receptors in the process and 3 establish a pipeline to discover relocalization domains and cytoplasmtargeting toxic domains in t6ss effectors the discovery of specialized t6ss effector relocalization domains will revolutionize our understanding of effector modularity and trafficking during competition furthermore such domains are key in developing tools to identify novel toxic domains and engineer synthetic toxins as alternative antibiotics