Dragon09/odtu_chatbot huggingface dataset:
development of myopathies in broiler chickens with a special insight into spaghetti meat

to meet increasing demands for highvalue proteins broiler selection programs driven by growth rate led to the development of wooden breast wb white striping ws and novel emerging and unexplored myopathies such as spaghetti meat sm in light of the current situation demyo project will address important questions in todays myopathies research is it possible to detect myopathies in birds early age are there early differences between animals that will show myopathies at slaughter and the others or not whats the difference among animals developing ws wb and sm the novelty of the present proposal lies in the innovative application of advanced methodologies based on omics platforms to understand the molecular mechanism involved in the development of broiler myopathies in both sexes the added value of the project is in assessing if nutritional manipulation with nabutyrate might be used as a feeding strategy to decreases the occurrence of sm the project will be developed for 2 years by means of 6 wps candidates diverse scientific background in food science and veterinary medicine and advanced training from bca and dafnae departments unipd reinforced with secondments at the university of bologna universitat politecnica de valencia and wisconsismadison under supervision of the leading experts in the field will maximize the success of the research project and the candidates career goals communication dissemination and results exploitation will be addressed to multiple stakeholders by different tools at national eu and international levels results from this multidisciplinary project will have a scientific impact with novel information about myopathies to be adopted in the practice while meeting sdg 1 3 5 and 12 improving animal welfare meat quality and mitigating economic losses msca project will be a career breakthrough help the candidate established a position in the field empower her role as a female scientist and provide her with skills and opportunities for further grants
simplifying the snapadar tool for broad usage in life science research and drug discovery

rna base editing is a promising approach to manipulate genetic information in a transient and dosable way which breaks new ground in basic life science research and drug discovery in a preceding erc cog action we have engineered the snapadar tool which allows for the particularly precise efficient and programmable adenosinetoinosine rna base editing however the broad usage of this tool is somewhat hampered by the need for designing the chemically modified guidernas which currently includes some peptide bondforming chemistry and nucleic acid gel purification in this poc action we aim to simplify the tool to make it available for a larger section of the life science community specifically we aim to simplify the chemistry and the compounds to such an extent that a snapadar kit is obtained which enables the life scientist to perform the required chemistry without special equipment or chemistry skills furthermore the kit would include a reliable and simple protocol to perform efficient and precise editing reactions in mammalian primary cells profit could particularly be generated from the selling of the chemically stabilized guidernas we envision that the product would find application in the modulation of protein function like signaling cues and metabolic pathways and may foster the target screening and target validation in drug discovery efforts which are currently ongoing in the field of rna base editing the action also contains an analysis of the ip landscape and at the later stage of the action we aim to involve industrial partners for commercialization
next generation high power fuel cells for airborne applications

newborn focuses on realistic and commercially viable project outcomes significantly exceeding the call topic expected outcomes this is the only path to bring a real impact well beyond paperwork and test rigs with this in mind the project applies the steppingstone principle and intends to bring aviation graded fuel cells into the market as soon as safely possible this will generate operational data to support certification on cs25 aircraft it will further provide vital acceptance gap mitigation in the conservative air transport environment the 18 multidisciplinary partners including 3 nontraditional aerospace partners and 2 smes will work on 28 key enabling technologies they will be matured and optimized to support an eis of cs23 aircraft by 2030 and regional aircraft by 2035 the ambition of the project is to achieve an overall propulsion system efficiency of 50 by 2026 calculated as a ratio of energy on the propeller shaft to the hydrogen lower heating value this ambition greatly surpasses the expected outcome of the hpa02 call similarly by the end of 2025 the project will demonstrate widely scalable fuel cell power source technology with a power density of 12 kwkg and stack power density of 5 kwkg technologies will be adaptable to different maximum flight altitudes of fl250 and fl450 and scalable down to 250kw and reusable for secondary power in smr flying altitudes by 2026 an innovative cryogenic tank concept will be integrated demonstrating a gravimetric index of 35 for the cs23 aircraft and scalable up to 50 for regional aircraft the project will also address high power density high voltage energy conversion propulsion systems and the next generation microtube heat exchangers along with an accurate digital twin of the overall system all together newborn will develop a technology demonstrator prepared for flight demonstration in clean aviation phase 2
surgify safety burrs for safer bone surgery

6 out of 15 top surgical procedures include bone cutting which are performed using surgical power tools such as highspeed drills these drills are widely used in neurosurgery otology ear and spinal procedures which include some of the most demanding surgical bone operations however 30 of bone drilling surgeries can lead to severe soft tissue injury missing a target by only millimetres or applying slightly too much force can lead to severe complications threatening patients life the revolutionary surgify safety burr enables surgeons to cut bone accurately and efficiently without compromising the safety of important soft structures thanks to the scalable technology the safety feature can be customized for wide range of applications eg orthopaedics pediatrics or even roboticsassisted surgeryduring the eic project surgify safety burr product platform will be designed developed and commercialized to allow safer surgeries for everyone
the rise and decline of a solidarity movement palestinians and the radical left in west germany 1950s1980s

this project studies the shifting trajectory of propalestinian activism in west germany between the 1950s and 1980s at its center is the question of how we can explain that contemporaries in west germany began to support palestinian politics and later withdrew their solidarity in order to answer this question the project will study for the first time palestinian and german archives together with this approach it proposes a new focus on the role of migration and ties to the middle east for solidarity politics in the west german leftthe reasons for the rise of palestine solidarity movements during the 1960s and their decline in the 1980s are a muchdiscussed topic in the history of the western european left with the legacy of the holocaust and an earlier support for israel in the west german left this trajectory is particularly puzzling in the case of the federal republic historians have sought to explain this puzzle by focusing on continuities in the history of antisemitism and a changed perception of israel after the sixday war of 1967palsol breaks new ground by studying palestinian sources on the solidarity movement in west germany these sources provide a fresh vista on everyday interactions and the role of the palestinian diaspora in bridging leftist politics between places like beirut and bonn pursuing a transregional approach the project promises to shed light on how political struggles in europe and the middle east became integrated and disintegrated between the 1950s and 1980s
get connected

with get connected we create the opportunity for researchers and citizens of noordnederland to meet each other and interact in the european researchers night and researchers at schools activities based upon the experience with the nights in 2021 2022 and 2023 the consortium of the university of groningen ug forum groningen and their partners is eager to organise these events again in 2024 and 2025 at the heart of the consortium is the house of connections of the ug in which four ug schools of science and society connect researchers and other stakeholders to find solutions for the societal challenges in energy sustainability health and digitizationin get connected we will organise an attractive mix of events the main event is the science festival european researchers night groningen in which we plan to collaborate with other nightorganisers in europe in 2024 the theme is living in a smart world and in 2025 it is create your future pre and postevents are a science festival for kids a week of connection with events of each of the ugschools an interactive exhibit create your future and participation in the world cleanup day for the researchers at schools initiative we will organise a science educational programme plastic what a waste this programme for pupils of primary and secondary schools includes a citizen science project visiting researchers and a travelling science truckwith our programme we aim to engage the general public in northern netherlands with researchers work with emphasis on people with low socioeconomic status as they have higher risks in the societal transitions and less access to science we expect to involve about 180 researchers and 30000 citizens we expect to engage a diverse public and hope to help people make better funded decisions for their daily life feel more connected to regional and international policies and ri initiatives and to plant a seed in children for a scientific career
ant navigation understanding the resilience and selfdeveloping nature of minibrains in interaction with their environment

organisms differ from machines in their resilience their capacity to spontaneously recover from defects this is because organisms contrary to machines are selfdeveloping systems that change over time like a melody that sings itself the plastic mechanisms that enable animal and human selfdevelopment and resilience is barely known but understanding them would profoundly impact how we apprehend brains behaviours and their evolution resiliant will tackle this question using the stunning ability of solitary foraging ants to visually navigate in complex environments ant navigational behaviours develop through stages with strong learning components and can recover from sensorymotor alterations that would disable any machine the advantage is that the full ontogeny of these behaviours unfolds in a couple of days can be easily manipulated and involves a brain numerically much simpler and betterknown than any vertebrate we will combine an ecological approach complexity science and modelling with stateoftheart technologies to dissect the mechanisms underlying these behavioural developmental processes we will track ant ontogeny under different scenarios perform straightforward manipulations to disclose the underlying rules and use virtual reality to probe their ability to compensate for severe sensorymotor defects in parallel we will explore how these processes are implemented in the light of our everincreasing knowledge of insect circuits by augmenting our current neural models with network plasticity and recurrent connections between brain areas the evolutionary causes and consequences of such plastic neural topologies will be investigated using neuroevolution algorithms selecting for selfdeveloping agents that forage in reconstructed environments the dialogue between simulations and observation will move us towards a concrete understanding of the selfdeveloping nature and their fundamental and societal impact
earthquake energy radiation across spectrum a multidisciplinary study

destructions left after an earthquake are mostly caused by highfrequency ground motion that originates from the seismic source i will exploit the natural continuity between geodetic and seismological data to illuminate highfrequency sources and their relations with changes in earthquake rupture speed i propose an innovative bayesian 2step kinematic inversion in the frequency domain to investigate these destructive and poorly constrained highfrequency sources this probabilistic approach is based on nearfield data and a detailed analysis of the model parameter uncertainties which allows better locating the hf sources the project will bring new insights into how highfrequency relates to tectonic features both in subduction zones and large continental faults erasmus will be a collaborative effort between different earthquakerelated communities to generate knowledge that can be included in more reliable seismic hazard assessment impacting society significantly
spatialising career interventions for inclusivity and sustainability

the spatialising career interventions for inclusivity and sustainability spaciis project aims to address rural sustainability through the unusual perspective of career education and guidance ceg provision existing research shows that rural ceg provision can encourage young people to leave their rural communities and the project aims to ask whether ceg provision can be reimagined to more fully meet the needs of rural young people and their communities the project takes an interdisciplinary approach applying insights into placeconscious practice and place and social justice developed in the field of rural education to rural ceg provision utilising research circles rcs a form of participatory research the project engages three rural danish communities in researching the needs of their communities and codesigning placeconscious ceg interventions the project contributes to scholarship in ceg by developing a new conceptualisation of social justice for ceg including consideration of spatial aspects of inequality and developing a new models of placeconscious ceg provision the project also extends rural development scholarship by exploring the role specifically of ceg provision in economic and population sustainability of rural communities contributing to rural education scholarship the project highlights the role of ceg provision within communityeducation linkages and explores the value of rcs as an innovative way to bring together different perspectives and generate community led innovations in this provision practical outputs include the development of tools for delivering placeconscious career education that can be adapted for use across different rural communities ceg services and ceg practitioners through these outputs the project seeks to improve the quality and efficiency of rural ceg services
the modern argonauts a multicultural educational programme preparing young people for contemporary challenges through an innovative use of classical mythology

the preamble to the eu charter of fundamental rights speaks of the peoples of europe who are conscious of its heritage and wish to share a peaceful future based on such common values as dignity equality and solidarity one of the crucial sources of these values is classical antiquity which laid the foundations for many ideas shaping our contemporary world in particular the ancient myths and their reception build a sense of community and a code of reciprocal understanding so important in times of growing separatist tendencies and they permit us to address issues relevant for our societies eg war troy migration aeneas disability minotaur ecology dryads and pandemics oedipus even the dark sides of the classics like slavery and the discrimination of women offer vital impulses for discussion of our current challenges with a limited risk of trauma for the myths are perceived as both close to and detached from our realitythis heritage of such amazing potential is vanishing however from school education which loses its connection with research we respond to this problem with a unique programme conveyed via a handbook for high schoolers the handbook will draw on materials from the our mythical childhood consolidator grant incl the groundbreaking animations of ancient vases its chapters will contain examples of myth reception from all the eu member states along with the extraeuropean contexts covered by my team members and experts from australia cameroon israel uk usa etc it will have a game format its users will play modern argonauts on a voyage of discovery of the shared mythical heritage owing to the collaboration established by the pi the handbook will be promoted by such leading bodies as fdration internationale des associations detudes classiques cambridge school classics project and associazione italiana di cultura classica thus providing societies worldwide with an innovative model for researchbased education
hybrid biomethane production from integrated biomass conversion

the ongoing decarbonisation of the energy and transport systems is a current challenge in europe as the rising prices of fossil natural gas make evident the need to increase renewable gas capacity is undeniable and goes hand in hand with solving bottlenecks that current biomethane production technologies cannot effectively address the hyfuelup project aims to demonstrate a flexible and hybrid pathway for the efficient and costeffective production of biomethane through thermochemical technologies combined with renewable hydrogen a complete deployment value chain including biomethane offtake and distribution will also be demonstrated to contribute to the market penetration of biomethane in key sectors thanks to the broad composition of the consortium the project will blend market knowledge with advanced academic and industrial perspectives to demonstrate the production of biomethane at scale first the flexible conversion of lowgrade feedstocks via sorptionenhanced gasification will be validated coupled with syngas or flue gas cleanup in a demonstrator at trl6 then a second demonstrator will also validate fluidisedbed methanation of either syngas or flue gas with the dynamic addition of hydrogen at trl6 before both technologies are integrated into a third demonstrator to produce biomethane at scale and reach trl7 together such developments work toward reaching the impacts of the work programme and lead to relevant changes in action and practice via two welldefined impact pathways technological development and adoption and enhancing capacity that will ultimately help strengthen the european scientific leadership for the development of a highly competitive renewable gas industry widen the technology portfolio of biomethane production technologies and improve citizen wellbeing via reduced climate and social risks
deciphering the role of protein spalmitoylation in skeletal muscle physiopathology

duchenne muscular dystrophy dmd is the most prevalent form of childhood muscular dystrophy affecting approximately 1 in 3500 newborn boys dmd patients experience earlyonset and rapidly progressive muscle weakness leading to the loss of mobility and premature death the burden of muscular dystrophies extends beyond the physical challenges faced by patients indeed it poses significant social and economic implications impacting patients quality of life necessitating social welfare support and incurring substantial healthcare costs so far there is no cure for dmd emphasizing the urgent need to intensify research efforts aimed at uncovering new pathomolecular mechanisms and developing treatment strategies protein lipidation especially protein spalmitoylation has gained attention in several diseases but its role in skeletal muscle function and dystrophic conditions remains completely unexplored myopalm is an innovative project that aims to bridge this knowledge gap by investigating the contribution of protein spalmitoylation in adult skeletal muscle function this will be accomplished through in vivo manipulation of the enzymes involved with this pathway and using cuttingedge palmitoylproteomic approaches furthermore by exploiting the mdx mouse model we aim to explore the potential role of protein spalmitoylation in the pathogenesis of dmd by unravelling this unexplored perspective myopalm aims to lay the foundation for identifying new druggable targets paving the way for future therapeutic strategies to benefit dmd patients through collaboration between the cole polytechnique fdrale de lausanne ch and the university of padova it the applicant seeks to reinforce his technical skills and scientific knowledge aspiring to become an independent researcher within the european union
indigenous women interconnecting knowledge bodies territories and technologies for life

indigenous communities are the main ones facing the direct consequences of climate change due to their intricate relationship with the environment their culture and their resources in the case of the amazon environmental devastation and exploitation threaten the basic human rights of its native peoples which added to the impacts of climate change threatens the survival of its biodiversity in this plot indigenous women play a crucial role in the intergenerational transmission of ancestral knowledge about caring for the land the growing mobilization of indigenous womens organizations in resource preservation is highlighted in decolonial ecofeminist debates intertwining the rights of women and those of nature seeking alternatives for the preservation of life within this framework this project will examine how a new understanding of what constitutes evidencebased knowledge can become crucial for an ontological turn in forms of sustainable knowledge production and transmission to halt the destruction of amazonian biodiversity we refer specifically to the productive practices of indigenous women in their ways of preserving traditional knowledge we investigate the connection between the organizational forms of womens collectives in the amazon regions of brazilcolombia and their relationship with nature at another level we will conceptualize how indigenous and nonindigenous technologies can be intercepted for the creation of technologies that contribute to expanding the fields of action and sustainable development in the mitigation of climate change we will create a knowledge integration platform useful for indigenous and scientific communities by creating an openaccess data bank we will invest in legal frameworks that protect the intellectual and cultural property of communities and can enhance and drive future initiatives
innovative biobased building materials with thermal energy storage function

the aim of biobuild project is to develop and demonstrate fully biobased building materials with thermal storage function that can replace high environmental footprint products our solution demonstrates functional incorporation of biobased phase change materials biopcms into solid wood and wood fibres bound by plant oil resins lignin or fungal mycelia to produce novel biocomposite building materials with significantly improved thermal properties the novel materials possess a high multifunctional performance meet requirements for sustainable green production and ensure endoflife options and recycling environmental and social impacts and benefits are fully integrated into the lifecycle perspective