Dragon09/odtu_chatbot huggingface dataset:
the human genetic and immunological determinants of the clinical manifestations of sarscov2 infection towards personalised medicine

the consequences of sarscov2 exposure range from a lack of infection to lethal covid19 this immense interindividual clinical variability is the key scientific and medical enigma in the field while age and certain comorbidities are known to influence disease outcome these parameters do not explain all variation in addition there are other sarscov2 phenotypes of clinical importance multisystem inflammatory syndrome in children and adults misca and longcovid an important breakthrough to unravel the pathogenesis of covid19 came from our two science papers that were recognized by nature among the top 10 discoveries of 2020 we found that about 4 of patients with critical covid19 pneumonia had inborn errors of immunity iei that impair tlr3 and irf7dependent type i interferon ifn immunity and at least 10 of the patients carried preexisting autoantibodies autoabs neutralizing type i ifns these findings pave the way for further studies of covid19 pneumonia and other sarscov2 infection phenotypes and form the basis of the present research proposal undine which follows a bed side to bench and bench to bed side approach with the following objectivies i to decipher the genetic and immunological basis of the various sarscov2 disease manifestations to identify individuals at increased risk of critical covid19 postinfectious immunological complications and vaccine failure iii to develop readytouse diagnostic tests for largescale detection of autoabs to type i ifns and propose novel preventive and therapeutic approaches based on the pathogenesis of sarscov2 infection for translation into personalised medicine to achieve these goals our project will coordinate a european multidisciplinary and translational research effort relying on a strong and synergistic combination of assets including unique cohorts from 11 eu countries and stateofthe art human genetic immunological and virological expertises and technologies
automated synthesis of certifiable control software for autonomous vehicles

autonomous driving is a dominant technological theme of the 21st century with vehicles from various car manufacturers equipped with different levels of autonomy however the implementation of safe and reliable control software remains a critical challenge for car manufacturers before fully autonomous vehicles become a reality the current lack of reliability in autonomous vehicle software is mainly attributed to the absence of formal correctness design requirements are not expressed in a formal language leading to ambiguity and false implementations furthermore human factors from engineers to developers increase the likelihood of errors and testing scenarios are limited leaving many edge cases untested immature control software leading to accidents undermines public trust in autonomous vehicles and impedes further development we propose leveraging our ongoing erc project autocps research to create robust reliable and formally correct automotive control software certicar proposes a software development framework that automates control software generation and guarantees its robustness and reliability a reliable advanced collision avoidance system acas is a fundamental requirement for future autonomous vehicles significantly reducing the number of accidents injuries and fatalities certicars poc project aims to provide a correctbydesign acas with guaranteed correctness reducing testing time by several orders of magnitude for car companies and represents an initial step toward a complete software stack for a certifiable autonomous car
deep learning based interpretable pediatric brain tumors segmentation and classification

the dlipbratsc project aims to address the significant impact of pediatric brain tumors pbts as the leading cause of cancer death in children and adolescents artificial intelligence ai technologies are increasingly being explored to assist doctors in detecting and diagnosing through clinical decision support systems cdss however they face the challenges in successfully segmenting pbts due to the scarcity of available medical image datasets additionally the lack of transparency in blackbox ai models has raised concerns among doctors hindering the adoption of ai in cdss to tackle these challenges the project will develop a stateoftheart interpretable aibased framework to classify pbts including tumor segmentation dlipbratsc will identify the location of pbts classify of pbt types and enable quantitative analysis of subregion of pbt parameters helping clinicians in diagnosis treatment planning monitoring disease progression and predicting patient outcomes the project will start with collecting and preparing sufficiently large balanced pbt medical images from secondment institution with the assistance of medical experts an online test platform will be implemented for clinicians to use the model gathering feedback for further validation and improvements the nonacademic placement will provide realworld clinical validation of the models efficacy the project findings will be shared in conferences or journals targeting both neuroscience and informatics dlipbratsc can help healthcare providers make more informed decisions about diagnosis and treatment planning of pbts and contribute to early detection and intervention these can lead to better patient outcomes improved overall healthcare delivery and public health outcomes and reduced healthcare costs aligning with the eus objectives of providing ensuring the safety and wellbeing of its citizens and one of the irish national research priorities areas health and wellbeing
understanding gene environment interaction in alcoholrelated hepatocellular carcinoma

alcoholrelated hepatocellular carcinoma aldhcc is in europe the leading cause of liver cancer 2nd most common cause of cancerrelated death worldwide affecting both men and women aldhcc has a median 5year survival rate of 15 yet the prognosis is driven by the tumour stage with curative options providing a 5year survival exceeding 70 for earlystage hcc 20 of cases therefore interventions aiming to improve prevention and early detection are key aldhcc results from the interplay between environmental determinants and genetic variations a comprehensive characterisation of environmental factors eg diet lifestyle linked to aldhcc is still lacking we recently performed the 1st genomewide association study of aldhcc and identified predisposing genetic variations however their role on alcoholrelated liver carcinogenesis needs clarification and the genetic architecture of aldhcc remains mostly unknown genial brings together partners with unique expertise in clinical hepatology singlecell and spatial multiomics artificial intelligence ai and communication and dissemination capacities our aim is to 1 portray genetic and environmental determinants promoting aldhcc 2 evaluate how they interact at cellular level in human samples and preclinical models to get novel insights into liver carcinogenesis and identify chemopreventive targets and 3 assess how these determinants modulate the aldhcc risk in prospective cohorts of patients included in hcc surveillance programs environmental factors will be comprehensively characterised in an ongoing clinical trial designed to evaluate alternative methods for earlystage hcc detection finally ai models reaching the minimal viable product stage by the end of genial will be used to integrate genetic and nongenetic information including digital imaging to develop novel costeffective strategies towards prevention and earlystage detection of aldhcc in atrisk individualsthis action is part of the cancer mission cluster of projects on understanding
sustainable photoelectrochemical valorization of flue gases

in the road to sustainability the treatment of postcombustion emissions is still far from being technoeconomically viable on one end the low concentration of co2 in these streams precludes the use of current carbon capture cc technologies on the other end even if cc were successfully implemented there are not plausible final uses maybe except geological longterm storage our ambitious proposal aims to investigate the viability of a technology able to tackle these challenges at once our superval technology will develop scientific solutions from lowcost noncritical raw materials and processes with the added value of removingvalorizing the nox contaminants from flue gaswe propose to design and realize an autonomous solarpowered installation able to capture harmful emissions from flue gas and valorize them as commodities for the chemical industry using water as sacrificial source of electrons and protons the co2 will be transformed into an organic energyrich molecule formate the nox will be also captured and transformed in combination with n2 into ammonia using the hydrogen obtained in the co2 coelectrolysis processes this integrated effort will offer the comprehensive capture and valorization of carbon and nitrogen components in postcombustion emissions thus limiting pollutants and resulting in addedvalue chemicals the corresponding technoeconomic analysis and life cycle assessment studies will help to shape the components and performance of superval as a useful technological advancement in the search for zero net emissions
the glue of society a social ontology of social cohesion

social cohesion is a key concept in how we think about the social world and yet we have a very poor conceptual understanding of what social cohesion is how it relates to other social phenomena and which role it plays in maintaining social order and facilitating cooperation to date this challenge has not been taken up by social ontology contemporary social ontology primarily focuses on understanding the nature of collective cooperation in which people coalesce around a joint purpose in such a way that we can attribute attitudes and actions to them as a collective rather than as an aggregation of individuals but social cohesion is not only a function of collective cooperation but also the extent to which a social system enables mutually sustaining cooperation among agents with separate goals call this converging cooperationit seems then that social cohesion is a key concept in how we think about the social world that lies beyond the scope of social ontology in its current form responding to this impasse the aim of the glue project is to secure philosophical clarification of the concept of social cohesion and to account for its role in constituting and maintaining the social worldthe primary research questions are1 what is social cohesion and which distinct social phenomenon might it refer to2 what are the semantically explanatory relations between a social cohesion and b the concepts often used in social ontology and the social sciences to account for collective cooperation3 how can a clearer account of social cohesion be used to foster social stabilitycombining descriptive explanatory and critical approaches to social ontology glue a enriches our typology of social dynamics b expands the scope of social ontology beyond collective cooperation c introduces concepts that can help identify and mitigate forms of social destabilisation and d develops a new and integrative research method for social ontology
particle composition in relativistic jets

relativistic jets launched by supermassive black holes are the most extreme and energetic persistent phenomena in the universe they are capable of accelerating particles to energies inaccessible by particle accelerators on earth and deposit enormous amount of energy in their surroundings during their lifetime they are believed to have a significant impact on galaxy evolution via feedback mechanisms yet despite decades of studies one of the most fundamental properties the composition of these jets is still unknown the jets can consist of either electronpositron pairs electronproton plasma where also protons are present and accelerated or an admixture of the two the composition affects the power of the jet and the presence or lack of hadrons is a crucial ingredient in modelling the multiwavelength and multimessenger emission of these jets if the jets are hadronic they are likely the origin of the highest energy cosmic rayscircular polarization is the only direct way to determine the particle composition of jets and we have designed a project that will overcome limitations of previous programs to finally resolve the particle composition of relativistic jets previously this has only been attempted on individual objects at low radio frequencies or using singlefrequency data lacking the required discriminating power particles will deliver the first multifrequencyradio highcadence observations of relativistic jets in total intensity linear and circular polarization for a sample of objects in parallel we will conduct very long baseline interferometry observations to connect our light curves with the spatially resolved structures in the jets this unprecedented dataset will be combined with radiative transfer simulations crucial for modelling the origin of circular polarization these advances will enable us to answer one of the most central questions related to relativistic jets what is their particle composition
contribution of the epsteinbarr virus and the tumour microenvironment to antiapoptotic mechanisms in dlbcl

diffuse large bcell lymphoma dlbcl accounts for over onethird of lymphomas and is fatal in up to 40 of cases particularly poor survival is associated with dlbcl subtypes that overexpress the oncogene myc and contain the cancercausing epsteinbarr virus ebv these tumours frequently resist apoptosis with a poorer response to chemotherapy recent evidence has strongly implicated a role for the tumour microenvironment tme in cancer progression however the relationship between ebv myc and the tme in dlbcl remains poorly understoodcomand aims to elucidate the synergistic relationship between ebv myc and the tme to explore how these oncogenic drivers converge to protect dlbcl tumours from apoptosis this will be achieved using a new generation of ebv and ebv dlbcl models to derive novel insights into the biology of ebv dlbcl this will be coupled with stateoftheart intravital imaging of tumour progression in humanised mice and highly multiplexed spatially resolved imaging of the tme in ebv patient tumours this will allow the study in unprecedented detail of the impact of viral and cellular oncogenic drivers on the tme and apoptosis in dlbclthis research directly contributes to cancer and infectious diseaserelated eu and un goals and will support the areas of open science gender equality and the green charterthe fellow will spend 2 years at the walter and elisa hall institute of medical research australia expanding her skills in in vitro disease mimetics and acquiring a skillset in apoptotic pathways and intravital imaging she will return to the university of limerick ireland and receive training in highdimensional imaging and data analyticsthe fellow will be immersed within a multidisciplinary team with expertise in lymphomagenesis virology apoptosis and the tme they will support her in meeting the researchtraining objectives and preparing for an independent career in the field of ebvassociated lymphomagenesis
twinning innovation hub for microbial platforms in plastic upcycling

plastics have become indispensable in various industries today but their widespread use has resulted in a severe environmental crisisplastic waste accumulation traditional methods of plastic waste management are insufficient and recycling faces quality and degradation challenges enter upcycling a process gaining prominence in converting plastic waste into valuable chemicals and materials in an ecofriendly mannertwinn4microup presents an innovative approach to plastic waste upcycling employing green biomechanochemical technologies to recover plastic monomers modern molecular techniques will be utilized to create microbial cell factories capable of producing bioactive compounds from these plasticderived feedstocks revolutionizing industries related to biocolorants biotherapeutics bionutraceuticals biosurfactants and biomaterialstwinn4microup is on a visionary mission to create the microup hub an advanced research and innovation hub in synthetic microbial biotechnology in our pursuit of maximal impact we aim to establish strategic partnerships strengthen ntuas capabilities enhance scientific excellence and promote entrepreneurship and innovation our overarching goal is to establish ntua at the core of the microup hub leaving a lasting legacy by advancing scientific knowledge environmental protection public awareness economic development and global collaboration together we are steering toward a sustainable and responsible future
revitalising languages and safeguarding cultural diversity

languages have always played an important role when groups of people were living side by side speakers might be suppressed or take up a new language but as much as a language says a lot about individual identity it also carries a large reference to the culture and history of the group in which it is spoken and the cultural background it is tightly interwoven with emotions and traditions which are worth keeping up as they stand for personal rootsrise up interconnects all relevant knowledge actors including citizens civil society and end users it collects and analyses background information it identifies good practices and develops new methods with the help and support of people being concerned and interested in the topic thus rise up aims at the empowerment of these endangered language communities fostering their selfconfidence and overcoming past trauma in the understanding of the rise up consortium these endangered language communities include learners new speakers people who have not had the chance to learn their heritage languages supporters and other interested parties as well as actual speakersrise up explores and deals with a context reasons and policies for endangered languages within europe b collecting and creating a set of tools to support local communities c interconnecting relevant groups of stakeholders and d involving and attracting especially young people and other stakeholders eg by using digital tools
practices of unfreedom in northern france 8881121

the proposed project aims to fundamentally reframe the social history of the thousands of unfree persons living in france during the central middle ages it will do so by applying methods and frameworks from the growing field of the history of slavery and dependence moving away from redundant narratives of a transformation from antique slavery to medieval serfdom it will draw upon a wide range of documentary sources from four ecclesiastical provinces in northern france tours rouen sens and reims to create a database of the practices and interactions between unfree dependents and their lords in the period ad 888 to ad 1121 once completed this database will allow for a detailed analysis of the social and economic roles played by practices of unfreedom in medieval society the three key research themes of the project the imposition of unfreedom the agency of the unfree the historical record of unfreedom will be explored in two peerreviewed journal articles one in french and the other in english the researcher dr niall silleabhin will conduct the project over 24 months at the centre dtudes suprieures de civilisation mdievale cescm in poitiers a vibrant interdisciplinary centre for medieval studies the research will be conducted under the supervision of prof martin aurell an internationally renowned expert on the power of medieval social lites the projects training element involving mentoring digital training and participation in academic discussions and outreach will allow the researcher to develop transferable skills in archival research digital humanities techniques research project management and multilingual scholarly communication these skills in addition to the strengthening of existing collaborative european networks will significantly enhance the researchers career prospects allowing him to become an international research leader in medieval social history
toeplitz and related operators in large bergman spaces

we consider operator theory in bergman spaces consisting of analytic functions on complex domains the aim is to extend known central results of standard bergman spaces to the case of large spaces which are naturally defined by using rapidly decaying nondoubling weights the need of weighted estimates is as apparent as anywhere in harmonic analysis and applications in the context of bergman spaces the case of nondoubling weights is still partially open due to the fact that such weights are not so naturally related with the hyperbolic metric of the underlying domain in this context we plan to consider questions of boundedness of the bergman projection in weighted lpnorms in relation to the boundedness of toeplitz and also little hankel operatorsin the case of standard weighted bergman spaces there is a wellknown connection of the theory to the deformation quantizationanother topic of recent interest is formed by the so called localized operator classes we aim to extend these studies to the case oflarge bergman spacesthe methodology comes from the earlier joint works of the researcher and a number of well known experts in the area on the topicof pointwise estimates of the bergman kernel among others and from the techniques of the supervisor and wlusky as well as fockspacemethods which are naturally related to nondoubling measures
food safety for africa

the food safety for africa fs4africa proposal is designed to address food safety challenges in africa focus is given to addressing food safety issues associated with weak channels for value chain organisation traceability authentication of safe food food safety challenges addressed include mycotoxin contamination in multiple food crops including food and feed pesticide residues in grains and vegetables microbial contamination particularly escherichia coli contamination and food adulteration of foods the aim of the proposed proposal is to improve african food safety systems with particular attention to the informal sector through local market transformation enhancing food security and regional trade while reducing negative impacts on the environment biodiversity health and society to by utilizing expertise skills networks and tools available within the consortium comprising partners based in africa and europe we aim to address food safety challenges through policy development implementation of existing policies implementation of strategies uplift the informal sector using a combination of tools approaches to transform the informal sector to a mezzanine status utilizing digital tools communication of strategies utilization of sound scientific social and technological approaches tools in physical sciences social science and humanities including in behavioral science one health preservation of biodiversity is given attention in the proposal through implementation of interdisciplinary approaches that given consideration to human animal environmental and plant health by employing strategies that meet the needs of the present without compromising the ability of future generations to meet their own needs the proposed project will leverage on activities of other projects in previous and current eu projects and involve collaboration with the joint research center especially as ec knowledge center for global food and nutrition security