Dragon09/odtu_chatbot huggingface dataset:
perpetuating stemness from singlecell analysis to mechanistic spatiotemporal models of neural stem cell dynamics

neural stem cell nsc populations in the vertebrate brain generate adultborn neurons for plasticity growth and repair neurogenic and gliogenic capacity based on longterm nsc maintenance functionally define stemness stemness embodies massive nsc heterogeneity at the single cell level and requires control of maintenance or differentiation decisions at the population level these features remain mechanistically unreconciled we hypothesise that spatiotemporal interactions among heterogeneous nscs are coordinated to control the population behaviour thus we propose a multidimensional project exploring these features in time and space to decode the mechanistic principles of stemness to this end we bring together experimental and theoretical groups with complementary expertise in nsc biology biostatistics and mathematical modelling in an iterative experimentalmathematical approach we will 1 solve the topology of individual nsc trajectories in transcriptomic space 2 identify local cellcell coordination mechanisms that impact these trajectories in situ and 3 decode the resulting systemic properties and outputs of nsc ensembles at longterm and large spatial scales this programme will result in original methods including retrospective transcriptomics in single cells innovative barcode transfers and a novel mathematical framework to describe structured spatiotemporal population dynamics we will focus on two biological model systems the adult mouse ventricular subventricular zone and zebrafish pallium where nsc ensembles display comparable heterogeneity but differ in spatial organisation and fate dynamics together peps will uncover the general principles and regulatory mechanisms of perpetuating stemness in time and space it will lay the conceptual and methodological foundation to manipulate stem cell systems to improve their stability or output and also produce new methods of universal value for studying cellular systems
smart and sustainable host univercities leveraging cityuniversity interactions to further the twin green and digital transition

sunset aims to develop innovative research and training capacity around cityuniversity interactions driving the eus green and digital transition this twin transition is a defining element of the current eu policy agenda towards achieving climate neutrality and sustainable growth the european commission considers cities to be frontrunners in this transition agenda but their transformational capacity and resilience crucially depends on the presence of agile and highperforming urban innovation ecosystems sunset brings together 1 prominent researchers working in diverse geographical and disciplinary settings at leading universities n6 with 2 partners n16 from city governments often participating in the cities mission to achieve climate neutrality by 2030 innovation companies research institutes and civil society organizations to analyze and foster the performance of these urban innovation ecosystems drawing on a purposeful range of interdisciplinary international and intersectoral exchanges the doctoral network will investigate whether and how universities can successfully become key drivers of the twin transition in cities via their role as innovation partners the implementation of campus living labs and as architects of decisionmaking in governance ecosystems through a tailored combination of networkwide training events and academic and nonacademic secondments the sunset doctoral network will train a new generation of researchers to become future urban innovation ecosystem leaders in the pursuit of the twin green and digital transition the findings will lead to practical guidelines regarding the design and implementation of living labs for university and city management tailored strategies to foster more inclusive and diverse urban ecosystems and diverse forms of scientific outreach and dissemination
debiasing the uncertainties of climate stabilization ensembles

mathematical models have become central tools in global environmental assessments to serve society well climate change stabilization assessments need to capture the uncertainties of the deep future be statistically sound and track nearterm disruptions up to now conceptual computational and data constraints have limited the quantification of uncertainties of climate stabilization pathways to a narrow set focused on the current century the statistical interpretation of scenarios generated by multimodel ensembles is problematic due to availability biases and model dependencies scenario plausibility assessments are scant simplified singleobjective decision criteria frameworks are used to translate decarbonization uncertainties into decision rules whose understanding is not validatedeunice aims to transform the methodological and experimental foundations of modelbased climate assessments through quantification and debiasing of uncertainties in climate stabilization pathways our approach is threefold construct consolidate and convert we first apply simulation and statistical methods for extending scenarios into the deep future beyond the current century and status quo quantifying and attributing deep uncertainties we consolidate model ensembles through machine learning and human ingenuity to eliminate statistical biases pin down nearterm correlates of longterm targets and identify early signals of scenario plausibility through prediction polls finally we use decisiontheoretic methods to convert modelgenerated maps of the future into resilient recommendations and experimentally test how to communicate them effectively by advancing the state of the art in mathematical modelling statistics and behavioural decisionmaking we strengthen the scientific basis of climate assessments such as those of the ipcc the approach and insights of eunice can be applied to other highstakes environmental social and technological evaluations
synchronization of physiological rhythms between musicians and audiences in live concerts

heartbeats and breathing rhythms are essential to life labbased research suggests that certain contextual and social factors can impact the interaction between these physiological rhythms during joint actions such as ensemble playing synchinconcert aims at a cuttingedge contribution to the study of physiological rhythms by investigating for the first time to our knowledge the influence between the cardiac and respiratory rhythms of musicians and audiences in live concerts synchinconcert will also investigate how these rhythms reflect the aesthetics of the concerts and are influenced by social and contextual components three research events will be held with the stavanger symphony orchestra sso and a full audience in a concert hall during these events video audio cardiac and respiratory data from selected musicians and audience members will be recorded as well as questionnaires evaluating their level of immersion in the music a strong interdisciplinary approach will be adopted by integrating insights methods and techniques from several disciplines ie music performance science psychology physiology computer science acoustic engineering and cognitive sciences results can significantly contribute to the study of joint actions by identifying ways in which physiological rhythms support social interactions the hosts ritmo centre of excellence in oslo casa paganini in genoa secondment and sso placement offer a unique opportunity to strengthen my expertise in music psychology and performance focused on sound and behavioral components of interpersonal interactions in small ensembles to that of music performance physiology in large orchestras supported by the outstanding track record of research excellence of the host organizations the extensive mentorship experiences of my supervisors and the new set of skills acquired this fellowship will enhance my prospects for positions of independent researcher within and outside academia
tracing connectivity via ceramic technology in riverine environment of the middle danube region during the ottoman period

danube aims to study cultural connectivity among potters in riverine environment of the middle danube region during the 16th17th centuries which is a phenomenon of central importance for an archaeological interpretation of cultural change in central europe initiated with the ottoman expansion this interdisciplinary study combines archaeological and scientific analyses of common pottery with an anthropological theory on technology and written sources of the ottoman period to reconstruct the ceramic production technology and means of knowledge transmission along the danubesavadrava rivers common pottery included in danube is part of six largely unstudied archaeological collections from serbia and croatia and this project aims to highlight existing potentials of the middle danube region for archaeological studies of the postmedieval period focusing on pottery consumed in riverine settlements after the ottoman conquest the project explores links between ceramic morphology technology and cultural connectivity danube is the first study of riverine connectivity in postmedieval archaeology of central europe although danube deals with a specific region it can be used as an exemplar for addressing broader crosscultural and methodological questions regarding the role of rivers for networks of knowledge exchange and connectivity in the context of largescale migrations military pressure and cultural change the project introduces the regionalscale approach to ceramic studies in the middle danube region and goes beyond ceramic morphology to explore human interactions along large rivers of central europe danube benefits from the applicants sound research experience crosscutting archaeological and scientific studies of ottoman ceramics in southeastern europe combined with the access to materials from riverine sites and the prospect for synergies and expertise at the university of tübingen
improving forest drought resilience through tree xylem ecophysiological mechanisms

trees play a major role in earths water and carbon cycles climate change puts trees under a growing threat of droughtinduced mortality this already happens in europe where summers are becoming hotter and drier and across global forest biomes due to their large size and long lifespan trees need time to adapt and migrate time they lack under the fast rate of global change on the other hand foersts are amog the most important ecosystems we simply cannot afford to loseloss of xylem hydraulic conductivity due to eruption of air bubbles is termed xylem embolism despite many years of studying tree responses to drought it is still debated whether xylem embolism actually kills trees simultaneous processes like carbon starvation leaf desiccation and heat damage make it harder to pinpoint the direct effects of drought on xylem enbolism further while the extent of embolism avoidance has been characterized in many tree species embolism tolerance has been rarely studied and recovery processes are mostly unknown finally a wide research gap exists between ecophysiological mechanisms at the tree scale and implications at the forest scale this research proposal portrays a clear roadmap to resolving the open questions in tree hydraulic mechanisms under drought and to integrating them at the forest scale increasing drought resilience in forests through ecophysiological mechanisms requires 1 insitu field measurements 2 controlled experiments to decipher tree mechanisms and 3 advanced modeling to upscale treelevel measurements into the forest scale and support future forest managementwe will combine novel techniques custommade microct field detection of xylem embolism and water potential spatial mass spectrometry imaging and more field measurements and manipulations on mature trees greenhouse experiments on diverse tree species and computational modeling to test new hypotheses aimed at increasing drought resilience of forests
pathways towards carbon neutrality for climate environment health and socioeconomic cobenefits pantheon

pathways towards carbon neutrality for climate environment health and socioeconomic cobenefits pantheon offers a participatory integrated modeling approach developed via an iterative colearning process among researchers private and public stakeholders to assess how different mature and future trl4 technologies in crucial economic and energy sectors can be morphed into successful economically socially and environmentally sustainable joint decarbonization pathways the kernel of the project is a twotier innovative integrated assessment modelling framework that reconciles i goals for improving energy efficiencies decarbonization along the supply chain with ii socioeconomic impacts and challenges including health and labour and iii insights from informed stakeholders deliberations on a granular level nationalregionalsectoralfirm public stakeholders and stakeholders from sectors along the global supply chain
open science impact pathways

pathos aims to identify and quantify the key impact pathways of open science relating to the research system and its interrelations with economic and societal actors pathos will enable a new understanding of os impacts and their causal mechanisms through its workplan encompassing actions to synthesise and structure current evidence development of new methods and tools for measuring impact iterative pilottesting via indepth case studies innovative dissemination and networking and cocreation synthesis activities culminating in policy recommendations this is pivotal in order to develop effective os policy in the eu it will do so by collecting concrete evidence of the causal effects of os by studying the pathways of os practices from input to output outcome and impact including the consideration of enabling factors and key barriers impacts and pathways will be developed in particular in the three areas of science society and economy by investigating measuring and comparing its costs and benefits together with its pathways pathos will i bring a better understanding of the implications of open science for science economy and society ii provide recommendations to policy makers and other actors in the ri ecosystem as to how and to what extent open science should be promoted in a balanced way and iii develop innovative tools and methods using a big data to augment traditional ones for studying the causal effects of open science this will enable evidencebased open science policy prioritisation maximum os impact and increased ri capacity in eu research systems
interventions to promote mental and physical health in changing working environments due to climate change sustainable work practices and in green jobs

work environments are rapidly changing in europe the covid19 pandemic resulted in an acceleration of a range of complex and multidimensional trends at the workplace there is also increasing awareness of the importance of mental and physical health of workers and fundamental interconnections of work health and wellbeing climate change is further shaping the future of work on an unprecedented scale european economies are undergoing transformation and reorientation towards sustainability the european green deal is reforming the workplace through implementation of new sustainable work practices and policies circular economy solutions and rapid expansion of work in green jobs resulting in novel workplace exposures with likely impacts on health increases in complex algorithmic management and performance monitoring are also taking place with a view towards sustainability there have been calls towards inclusive green economies ensuring social protection and the creation of decent green jobs the overall objective of the intercambio project is to promote mental and physical health of workers in changing work environments due to climate change implementation of new working practices and among workers in green jobs we will examine key research questions regarding mental and physical health of workers and conduct detailed evaluation of interventions in strategic industries in europe relevant to green and digital transitions including in outdoor construction health care public transit renewable energy wind turbine and waste managementrecycling using a variety of multidisciplinary and stateoftheart research methods we will leverage large geographically diverse longitudinal cohort consortia for new climaterelated studies promote a framework for social protection and engage multilevel stakeholders findings are expected to have major scientific and societal relevance and will provide support for new policy action in occupational health
european researchers night in sweden 20242025 forskarfredag 20242025

forskarfredag researchers friday is swedens most widely dispersed science festival forskarfredag 2024 and 2025 ff202425 will consist of events arranged in 26 cities and an online programme open to anyone in total ff202425 will engage around 53600 attendees and 1150 researchersthe nonprofit association va public science has coordinated ff annually since 2006 ff202425 builds on previous years drawing on experience contacts and an everincreasing profile the ff motto is researchers are ordinary people with extraordinary jobsat ff202425 members of the public will meet researchers and participate in activities designed to stimulate dialogue and show that research is exciting and relevant to everyday life debates science cafes competitions shows experiments and handson activities common themes around eu priorities will inspire activities exploring the role of research in tackling societal challenges a collaboration with 7 other ern projects will deliver a set of europeanwide activities highlighting the european dimension of researchyoung people aged 619 are a key target group a school programme will offer numerous opportunities for encounters with research the borrow a researcher concept will enable 15000 pupils across sweden to meet a researcher in school or virtually as a researcher at schools initiative annual national mass experiments citizen science projects inviting pupils to work with researchers will involve appr 3000 peoplelocal events physical and some digital expected to reach around 35600 attendees will be organised by 10 partners and 18 external partners each event builds on local strengths and networks to give the highest possible impact all event organisers share experiences in a national network va is responsible for the coordination quality assurance common activities national identity awareness campaign and impact assessment of ff2425
fast brillouin microscopy for phase transition

multiple human diseases ranging from neurodegenerative disorders such as alzheimers disease to cancer have been found to be linked with biomolecular mechanical properties change phase transitions pts while these diseases have impacted many human beings 50 million for only ad the causes of most of these diseases are still mysterious and there is yet no effective treatment to understand the pathological role of pts and their corresponding potential as a therapeutic target for these diseases it is crucial to probe the mechanical properties of live cells current standard approaches to measuring the mechanical properties have important limitations requirement of contact force atomic force microscopy and optical coherence elastography and lack of cellular resolution ultrasound and magnetic resonance imaging an emerging tool brillouin microscopy bm provides the capability of imaging the mechanical properties through probing the socalled brillouin scattering spectrum in a noninvasive manner with 3d subcellular resolution its advent has led to a wide range of biological applications however the acquisition time for a standard confocal microscope size image is in the order of tens of minutes owing to the tradeoff between the measurement speed and the spectral resolution thus it prevents the bms from studying the kinetics of phase transitions in live cells fabrication is to substantially investigate invivo brillouin microscopy pushing the acquisition time to a submillisecond scale per spectrum while maintaining the high spectral resolution therefore permitting the measurements of the dynamic changes in mechanical properties of the living cells and tissues in subcellular resolution it will enable direct observations of biomolecular phase transitions and reveal their relationship with the pathological effects in cells the project will advance the research in understanding biomolecular pts thus bringing economic and societal benefits
towards reliable and safe gfr

gascooled fast reactor gfr is considered as one of the six most promising advanced nuclear reactor technologies supported worldwide by the generation iv international forum and esnii in europe with concepts under development in europe and the usa it excels in versatility combining very high core outlet temperatures and the possibility to close the fuel cycle allowing for very efficient and sustainable electricity and industrial heat production replacing burning fossil fuels the treasure proposal presents a research and innovation action aiming at connecting european developers of gfr demonstrator allegro v4g4 centre of excellence with expert organizations with experience in gfr and htr research who will utilize their unique expertise and knowledge and bring fresh ideas to the gfr development it is divided into 6 work packages four of them dealing with open research and development problems of gfrs namely the core operation and safety optimization wp1 experimental validation of the dhr concept wp2 gfr as industrial heat and power source wp3 enhancing gfr safety wp4 dissemination and outreach activities are included in wp5 alongside with communication activities with regulators and relevant international organizations and education and training activities wp6 ensures smooth management and execution of the projectthe main objectives of the treasure project arefurther optimization of the gfr fuel design and fuel cycleexploring possibilities to further reduce produced waste and to further enhance proliferation resistance in gfrsallegro safety concept demonstration including largescale experimental verificationoptimization of operation flexibility and performance of gfrs using intermediate heat storage system cogeneration and hydrogen productionfurther enhancing allegro safety via use of passive and redundant safety systemsattracting students and young professionals to work on gfr development