Dragon09/odtu_chatbot huggingface dataset:
neoc neuroenergeticsonchip disease modeling of impaired brain glucose metabolism using human ipscderived neurovascular units nvuonchip systems

neurological conditions conquer the world they are the leading cause of disability and second leading cause of death worldwide although there is growing evidence for the immense impact of disturbances in neurometabolism for overall brain function only little is known about the underlying mechanisms knowledge gap especially human insights are sparse due to a paucity of physiologically relevant model systems research gap to address these challenges within the scope of the neuroenergeticsonchip neoc project i am proposing the development of a novel human ipscbased organonchip model of the neurovascular unit nvu that integrates all neurometabolically active nvu cell types and specifically enables the inspection of neurometabolic coupling mechanisms to categorically cast light onto the mechanisms behind impaired metabolism of glucose the brains principal energy supplier i will build an nvuonchip disease model of glucose transporter 1 deficiency syndrome glut1ds since glut1ds is monogenic it presents an excellent paradigm to study cellular and molecular consequences of disturbed neuroenergetics even beyond the disease itselffor implementation of the neoc project i will i generate all neurometabolically relevant nvu cell types endothelial cells perivascular cells astrocytes microglia and neurons from human ipsc lines derived from glut1ds patients ii develop a novel nvu microfluidic platform addressing the shortcomings of existing nvuonchip systems and iii build glut1dsnvuonchip models to specifically study perturbations in energy metabolism bloodbrain barrier integrity and neuroinflammation as a consequence of glut1ds in vitrothe neoc project will provide novel knowledge on the underlying mechanisms and pathophysiology of glut1ds and thereby not only benefit those afflicted by the orphan disease but impact our understanding of a variety of other cns and metabolically linked disorders
nanowire device for single virus delivery and sensing in vacuum

airborne viruses causing respiratory diseases represent a mayor global health threat being viruses with rnagenomes from animal reservoirs highly likely to cause further public health emergencies in the future virquantify aims to provide proof of concept for a technology capable of highly sensitive fast and untargeted airborne virus detection with infectivity assessment providing a comparative advantage in the competitive landscape virquantify builds upon an unprecedented application of nms sensors to the field of airborne viral particles detection methodology developed and patented by the pi in the framework of a previous erc cog virquantify proposes the use of ionic liquids to preserve the virus structure together nanowire sensors that allow mass and stiffness measurements for identification and infectivity studies of the pathogens the innovative solution lies in two fronts 1 an unprecedented capability to measure with high throughput 30 particlesminute the stiffness of intact viruses to infer their infectivity potential not at reach to other techniques 2 the capability to count and characterize all the viral particles present in the liquid sample without loss of bioanalytes during the measurementsvirquantify aims to exploit the novel technology for onsite identification and quantification of airbone viral particles and validate the innovation potential of such technological tool for commercialization by developing a market entry strategy built upon ipr consolidation and spinoff setup this will lead to highgain disruptive outcomes in the form of unprecedented mechanistic understanding for detecting the quick spread of airbone viral particles with great socioeconomic benefits visible at three levels 1 fuelling industrial innovation and economic growth in a gamechanging sector preventive medicine 2 reducing healthcare costs worldwide thus enabling more resilient and efficient health systems 3 improving human welfare
faradaic miniaturising gas sensors to enable new sensing possibilities in iot devices

faradaic is bringing to the market the first miniaturised electrochemical o2 gas sensor to enable new sensing opportunities across different industries where a small chipbased sensor is demanded breathing devices fitness medical hydrogen economy etc gas sensors today are too large and expensive for the iot devices that device manufacturers want to build this problem is particularly painful when o2 gas sensing is needed since no miniaturised costeffective chipbased o2 gas sensor is available commercially we are combining the world of cuttingedge synthetic chemistry and advanced materials with the world of semiconductor manufacturing and microfabrication to achieve smaller costeffective and powerefficient gas sensor technology we are the first company worldwide that has successfully miniaturised the electrochemical variety and our goal is to lead the next sensor revolution with our gas sensing platform untapping all the potential of gas sensing in multiple markets
unravelling novel mechanisms of defense gene activation a gateway to elevate disease resistance in plants

plant diseases are widespread and constitute a major threat to food production understanding the molecular mechanisms by which plants resist pathogens is essential to design better strategies for protecting crops from diseases strict regulation of plant defense gene expression plays a critical role in establishing an effective and finetuned immune response their insufficient expression leads to diseases while their overexpression can result in autoimmunity and severe fitness penalties my own recent work using systems biology approaches reveals hidden components inferred by defense gene regulatory networks as essential players in plant immunity the next challenge lies in establishing how the recognition of pathogens by plant immune receptors is converted to changes in defense gene expression and results in effective immunity in particular it is unknown how defense gene regulatory mechanisms are dynamically regulated whether the mechanisms are shared by different plant species and how different types of plant cells respond to pathogen attacks my longterm goal is to develop robust tools to control plant pathogens to tackle these challenging questions the relevation program addresses three core objectives1 determine how master transcription factors regulate the expression of defense genes2 identify and characterize new and conserved regulatory components during immune activation3 elucidate and compare celltypespecific gene regulatory networks between resistant and susceptible plantswith my team i aim to advance the fundamental understanding of dynamic gene regulatory mechanisms during plant immune activation that are conserved in different plant species i additionally aim to revolutionize plant protection strategies at the celltypespecific level translating our results into crop plants will enable the development of management strategies including selectable traits for plant breeding for more durable and finetunable resistance
investigating the contribution of vanadium nitrogen fixation in ombrotrophic peatlands and their drivers in the present and in the past

ombrotrophic peatlands are important carbon sinks and sources of greenhouse gases the evolution of peatlands with global environmental change will depend on the availability of new nitrogen n which enters these ecosystems mainly through biological nitrogen fixation bnf recent research has demonstrated the emerging role of vanadium vbased bnf in complementing the canonical molybdenumrequiring process it supports n input in high latitude areas questioning our estimates of n input fluxes and our understanding of the interaction between macro and micronutrients in terrestrial biomes the role of vbased n fixation and its control in the present and past of peatland ecosystems has yet to be unveiledvanapeat will address these critical questions by using peat cores as an archive of the interaction between essential trace metal molybdenum and vanadium and nitrogen cycling in the anthropocene last 400 years and the holocene we will first investigate modernday contributions and trace metal controls over n cycling in ombrotrophic peatland environments using isotopic geochemical methodologies i helped develop we will then determine past fluctuations in mo and v availability to peatlands and their human geological and climatic origins using peat cores spanning periods up to the last glacial maximum last 30000 years finally we will investigate new isotopic proxies to track the contribution of v to bnf and link the fluctuations in metal deposition with vsupported n input along the holocenevanapeat will transform our understanding of the n cycle in present and past peatland ecosystems and ameliorate our projection for the terrestrial carbon sink during global environmental change it will investigate the earliest impact of human civilization and industry on natural ecosystems and inform policy decisions related to peatland conservation vanapeat will diversify the applicants research and help him reintegrate into european institutions
unveiling dynamics of rapid erosion through advanced seismic techniques

floods and landslides are an intensifying hazard in the context of climate change that affected over 2 billion people worldwide between 19982017 in mountainous catchments these processes play a significant role in rapid erosion contributing to landscape evolution yet multiple barriers limit our current understanding of rapid erosion dynamics such as the applicability of theoretical transport laws to complex realworld systems poor understanding of the mechanism behind the initiation of rapid erosion processes and sparsely distributed observations in time and spacethe unrest project will cut this gordian knot by pioneering an interdisciplinary observational framework that integrates several stateoftheart seismic techniques spatially dense arrays seismic interferometry and machine learning with physical and numerical models on a previously unexplored spatiotemporal scale this will be done through three main objectives 1 identify precursors and magnitude indicators of impending landslides 2 link seismic signals to complex landslide dynamics and 3 develop new tools to track unstable flood flow across multiple scales the project will be conducted in four active alpine catchments in france and switzerland with the developed methods tested in an entirely different geomorphic geologic and climatic setting of new caledonia a south pacific island unrest will unveil critical thresholds in damage development on unstable slopes and previously unobserved patterns and behaviors in complex flow dynamics these findings augmented by the development of nearreal time data processing workflows will have a transformative impact on the understanding of rapid erosion dynamics paving the way to enhanced warning systems in mountainous catchments
western images of the steppe empresses literary and film portraits of genghisid women between fascination and fear 20th21st centuries

since the middle ages the name of genghis khan has been associated in the west with the idea of the apocalypse in accordance with this negative representation the women who contributed to the rise of his empire have long been described as sinister witches and warriors indistinguishable from the men of their horde however studies carried out starting in the last century thanks to the opening of mongolia to the west and the rediscovery of new local sources have led western scholars to a profound revaluation of genghis khan now seen as one of the makers of the modern world this revaluation has also affected our view of mongol princesses who enjoyed a freedom and a consideration unknown to their sedentary neighbors wise and resilient they took part like men in war politics and trade and could choose whether and with whom to marry western images of the steppe empresses wise is the first research in the field of comparative literature aiming to understand whether the new anthropological archaeological historical and philological studies carried out by the mongolists have triggered a change in the perception of genghisid female royalty in 20th and 21st century western culture it analyses their representation in american and anglophone francophone and italophone european literature and cinema wise seeks to understand the cultural reasons for the metamorphosis of the image in question and whether it is connected to the changed role of women in the west as a result of feminist claims moreover it explores the possibility of an oriental influence linked to the steppe culture on the model of emancipated and combative women prevalent in the west today the training at sorbonne nouvelle university and the cole pratique des hautes tudes will give me the opportunity to deepen my knowledge of mongolian civilization and to acquire expertise in orientalism gender and film studies to be added to my existing skills in comparative literature
preclinical validation and demonstration of peptichip an immunopurification microfluidic device and software for neoantigen identification and prioritization

clinical translation of cancer immunotherapies remains very challenging since 6080 of patients fail to respondthe challenge stands in identifying specific tumourfingerprints the neoantigens that are peptides expressed uniquely by cancer cells and that are capable of triggering an efficient immune response against cancer currently there is no standard method to identify antigens and the few methods available have significant limitations by being quite long complicated and resource demanding in response to this clear technological and market gap valo therapeutics valotx an immunotherapy development company is introducing peptichip ie an innovative microfluidic immunopurification device and a peptide prioritisation algorithm to identify the most relevant neoantigens to stimulate the immune system and thus increase the chance of success of the immunotherapy peptichip can be adapted and used to identify antigens related to any disease the proof of concept poc was successfully demonstrated at university of helsinki the ip was protected and valotx has full rights to further develop exploit and commercialize peptichip this eic transition project will allow further technology development testing validating and demonstrating it preclinically generating evidence to convince investors and stakeholders as well as to prepare an extensive and solid transitiontomarket plan t2mp by being accurate fast lowcost easy to use and working with very small amounts of samples peptichip will have great impact in 1 research for discovery new therapies development since identification of antigens allows the understanding of diseases immune response mechanisms 2 industry for therapy development translation into clinical use since the antigens identification prioritization is a critical step to produce therapies tailored for each patient to ensure responsiveness 3 clinic for patient assessment immunotherapy tailoring
innovative business models for soil health

the general objective of novasoil project is highlight the benefits for the society and the environment from the investment in soil health the main expected outcome of the project is a toolbox for the analysis of suitability of different business cases that promote soil health this toolbox will be based on a set of good examples from europe and other countries and the needs and demands from the society the toolbox will include a categorisation of the models and business cases taking into account a sustainable soil management under different land uses and climatic conditions b products based on practices promoting soil health c consumption and certification practices conductive d the reuse of land and e sustainable soil management in the context of the eu taxonomy regulationfor that novasoil is composed by a multidisciplinary team with a large experience on european and national projects focus on soil health and business models as well as novasoil will built a community of practice around project objectives in order to codevelop soil health business models and the toolbox for incentives taking into account their needs and demandsnovasoil is organised in 5 wps plus coordination following the expected objectives and impacts of the call the first step is to develop a conceptual framework of soil health and business this framework will nurture other wps in order to develop in the same way all the expected objectives the soil health business models will analyse current successful experiences in europe and outside europe in order to categorise them taking into account their variability in addition novasoil includes 13 case studies with business models that promote soil quality and products based on sustainable crop and soil management on the other hand an analysis of current policies related will be carried out in order to provide suggestions and improvement that facilitate the implementation of these soil health business
unrevealing the mechanisms involved when producing biodiesel from waste oil using a combined experimental and theoretical methodology

40 reduction on emissions should be achieved by 2030 within eu with the outstanding goal for europe to become the first climate neutral continent by 2050 these goals need to be reached without jeopardizing economic development and growth and simultaneously fulfilling the un goals for sustainabilityone of the main contributors to climate change and global warming is emissions from our vehicles as these mainly use petroleumbased fuels to address this new approaches methodologies and technologies must be developedbiodiesel is one option to substitute diesel however its production has been controversial since it requires the use of edible oils and thus creates conflicts with the production of food crops making it less attractive because of this problem newer technologies are being developed to treat lower quality nonedible oils however as yet these are not economically viableto address these problems unprecedented will focus on the use of waste oil this new raw material has been tested experimentally with promising results however how the reaction is taking place and the steps involved is far from being understood this lack of knowledge has a negative effect when selecting new technologies or testing new feedstocks unprecedented will use a combine methodology of experimental data and theoretical modelling dft based calculations to study and fully comprehend the biodiesel production reaction this methodology will permit a full understanding of the reactive steps involved the reaction pathway that is followed as well as the energies involved in each reactive step this methodology will assess for the conversion of waste oil in the presence of renewable alcohols to produce biodiesel when using new catalytic materials that are biobased produce from renewable sources and enriched with glycerol
empowering a fair and responsible european foodregister fostering citizen sovereignty and creating a datadriven food system

the overall goal of our project is to achieve trust in a datadriven food system by implementing digital responsibility goals for the food sector this will enable new levels of innovation for example in food safety sustainability personalized nutrtion reduction of food waste and fair conditions throughout the entire food chain the programme works on a clear strategic roadmap a new virtual food system a set technological enablers demonstration of solutions a structured funding programme with open calls and measures to guide and support the food ecosystem of third party beneficiaries citizens stakeholdersas a consortium we maintain the perspective that technology is not a means to an end but acts merely as an empowering enabler providing the means to achieve a wide variety of innovative and valuable use cases use cases that promise to serve a broader audience provided that adequate access also is considered as a prerequisite currently however technology is primarily developed from the perspective and needs of corporations and or authorities a limitation that risks perpetuating or further exacerbating the abovementioned lack of trust within the markets that they serve with a more diverse and humancentric driven perspective we believe the new use cases that will emerge and the technology development required to realise them will contribute to a more sustainable ecosystem that is trustworthy by default to truly design for trust the entire chain of activities and underlying assumptions towards developing technology has to be based on fundamental values like responsibility privacy and user control especially when dealing with valuable and sensitive food data the starting point of all assumptions needs to be the user and their values not a business model or legitimate state interests
research data alliance facilitation of targeted international working groups for eoscrelated research solutions

the rda tiger aims to provide services to facilitate and support welldefined working groups between key european and international initiatives resulting in concrete alignment harmonisation and standardisation of open science developments and technologies globally in particular the project will directly contribute to the european open science cloud partnership by supporting via the working groups the international engagement and alignment of policies technologies methodologies practices and other outputs of eoscrelated and other european open science developments and develop and offer a service platform for these working groups effectively identifying key partners for the groups and increasing their work efficiency by facilitation and other support actions and ultimately maximising the impact wg results have on the eosc global open science and societyrda tiger leverages the demonstrably effective instrument of communitydriven rda working groups and the foundations of eosc rda codata research software alliance resa and the open science movement in general and provides a way to efficiently use the rda platform for internationalisation and standardisation of research outputs that allow science to be reproducible and scrutinisedrda tiger service platform includes planning engagement communication facilitation and finalisation services to the working groups maximising the wg outputs and their impact most of the rda tiger services have been tested in one form or another in earlier rdarelated projects both in europe and internationally demonstrating that they are realistic and achievable rda tigers ambition stems from the concentrated use of these services together with systematic quality control and improvement mechanisms and via the careful selection of working groups which will maximize the impacts relevant to the work programme