Dragon09/odtu_chatbot huggingface dataset:
govsatcom extreme events crisis management service

protecting citizens and freedoms is one of the four european union priorities in its 20192024 strategic agenda with a priority to increase the eus resilience against both natural and manmade disasters the eus autonomy and independence is essential to implement the common security policy including the governmental communications satcom represents the ideal communication means for covering large geographical areas or operations deployed in remote or isolated sites the european union governmental satellite communications eu govsatcom programme aims at providing secure guaranteed and costeffective satcom services to eu governmental stakeholders such as member states ms and related security organisations and eu agencies or institutions with special emphasis on civilians its concept relies on the aggregation of the satcom demand and the pooling sharing of the satcom service supplygextrecs will define and demonstrate an endtoend govsatcom service supporting crisis management gextrecs will 1 prototype the dynamic planner in order to derisk an important govsatcom ground segment element in order to enable dynamic satcom resources allocation in the most optimal manner making use of advance heuristics 2 integrate a network balancer which will enable the required interoperability ensuring that secure communications are preserved when using different communications networks 3 illustrate govsatcom synergies with other components of eu space programmethe gextrecs innovation will be demonstrated in two use cases land and maritime in real enduser environments while exploiting synergies with other eu space programme components such as copernicus and galileo annual demonstrations will simulate exercises in land crossborder and multinational maritime use casesgextrecs partners covers the full satcom added value chain with gmv hisdesat ttcomm and the endusers isar csic complemented by polsa as hub of the entrusted network of users
precision cancer medicine repurposing system using pragmatic clinical trials

millions of people in the eu are negatively affected by cancer and cancer is one of the leading causes of death and morbidity in europe ecisjrceuropaeu the primerose consortium will contribute to the mission cancer goal to optimise treatment and support quality of life of more than 3 million people by 2030the primerose consortium envisions to support mission cancer through the following objectives 1 increase access to optimised and affordable treatment interventions for cancer patients that prolong life and increase quality of life 2 generate clinical evidence and evaluate effectiveness in precision cancer medicine pcmrelevant and synthetically randomised controlled academic investigatorinitiated pragmatic clinical trials and 3 work together across europe with relevant experts to implement evidencebased pcm in routine practice and address inequalities in accessthis consortium builds on the truly bottomup clinicianinitiated family of druplike innovative trials that provide broad access to precision medicine for cancer patientsthis action is part of the cancer mission cluster of projects on diagnosis and treatment
multi4 the first surgical instrument for bladder cancer treatment through a 20minute outpatient procedure

bladder cancer bc is the 5th most common cancer in europe with the incidence of 175000 cases annually and has the highest lifetime treatment cost of all cancers at the diagnostic step a cystoscope is used usually no biopsies are taken as there are no efficient methods to do so in the outpatient care if the patient has suspected cancer seen on the monitor they are scheduled for a surgery at the surgery step the biopsies are taken and the cancer is removed using a resectoscope the procedure is difficult to perform the instrument used is hard metal up to 12 mm in diameter and inflexible can damage the urethra there is a high risk of cancer reseeding elsewhere in the bladder up to 75 of bc patients relapse within 5 years the related costs in the eu are estimated at 5 billion annually no development has taken place since the 1960 when the existing instruments were developedwe have developed and patented the first medical device called multi4 which allows for local treatment of bc through flexible cystoscopy during one visit to the urologist the instrument has 4 functions 1 inject local anaesthesia through a thin needle 2 pieces of the cancer are cut by the specially coated forceps bleeding is stopped immediately3 the cancer tissue is automatically transported out through the instrument itself 4 when the forceps are closed they become a burning electrode used to burn the surface where the cancer was located and ensure that all cancer cells have been killedwith the multi4 platform the patient can have their cancer treated at the first visit to the urologist the procedure takes 20 minutes this technology can thus disrupt the existing healthcare pathways where bc is treated through expensive and complicated surgeriesthe proposed project will develop a gotomarket strategy for this groundbreaking deep tech innovation and empower the female founder to scale the company
planetary space simulations based on the particle description for electrons and ions

the question about how solar storms impact a planet has both fundamental scientific importance and greatsocial impacts for protecting our infrastructure from the most powerful solar storms at present models relyon a fluid description of the electrons due to algorithmic and computational challenges our goal is to developa model of the space environment around a planet based on a particle description of both ions and electronswe plan to use the particle in cell pic model where both ions and electrons retain their nature as particlesthis pic model will allow us to investigate the critical role of energetic electrons participating in the energyand matter transfer from the solar wind to the planet inner spacewhat makes this goal now possible is the energy conserving semi implicit method ecsim developed bythe pi the ecsim conserves energy exactly a critical element in the investigation of energy flow from thesolar wind in addition the energy conservation leads to enhanced numerical stability which in turn greatlyaugment ecsims capability to simulate very large systems such as planet atmospheres while treating electronsas particles rather than fluid we will start from this new development and introduce two critical innovationsfirst we will implement adaptive spatial and temporal resolution for finer resolution closer to the planet andin selected areas of interest second we will implement cpugpu algorithms for the new heterogeneoussupercomputers developed by eurohpcthese innovations will increase the capability of ecsim by more than an order of magnitude making it possibleto model a region as big as the earth space environment with the computers available within the next 35 yearsif successful we will have the first pic model to describe a planetary space environment where the correctparticle nature of the electrons is considered with all its implication for the energy and matter transport
fully integrated autonomous chemistry agnostic materials acceleration platform for sustainable batteries

battery technology emerges as a key solution for cutting carbon dioxide emissions across transportation energy and industrial sectors nonetheless traditional research methods for developing new battery materials have typically depended on an edisonian approach characterised by trial and error where each phase in the discovery value chain is sequentially reliant on the successful execution of preceding steps development and optimization of novel batteries is a process that spanned around a decade to face this challenge it is necessary to accelerate the discovery and optimization of nextgeneration batteries through the development of materials and interface acceleration platforms the fullmap project aims to revolutionize battery innovation by developing a materials acceleration platform that amplifies human capabilities and expedites the discovery of new materials and interfaces this pivotal initiative focuses on automating laboratory operations and conducting fast highthroughput experiments it integrates ai and machine learningaccelerated multiscale and multiphysics modeling supporting intelligent decisionmaking fullmaps comprehensive modular approach encompasses the inverse design of materials autonomous orchestrated production via both traditional and novel synthesis routes and extensive highthroughput characterization methods these methods span exsitu insitu operando online and postmortem analyses at various levels from material to cell assembly and testing it simulates the entire battery development process from material design to battery testing considering environmental and economic factors by integrating computational and experimental methods with ai big data autonomous synthesis and highthroughput testing fullmap aims to fasttrack the development and deployment of nextgeneration materials and batteries significantly advancing sustainable battery technology
linking metabolism and rna biology in neurodevelopment through a new pathway

neurodevelopmental disorders ndds affect 38 percent of children across europe and cause a lifelong alteration of cognitive abilities or social interactions with little therapeutic possibilities recent studies have uncovered that dysfunctional mitochondria and metabolism are involved in ndds like intellectual disability and autism spectrum disorder notably neuronal circuit development a crucial process during the formation of the brain is characterized by an increase in metabolic activity supporting a period of intense remodelling however the knowledge of molecular processes controlling metabolic homeostasis during neural circuit development is still incomplete we recently defined the autismassociated kinase nuak1 as a critical regulator of local mitochondrial metabolism in neurons supporting axon morphogenesis however it is not clear how nuak1 controls metabolic processes in neurons we have identified a novel substrate of nuak1 and hypothesize that nuak1 controls an alternative splicing program through this new interactor thereby regulating metabolism which in turn affects neuronal development we will 1 perform a phenotypical characterization of the novel substrates role in developing neurons in vitro and in vivo 2 investigate its effect on neuronal and axonal metabolism 3 characterize its associated transcriptomic signature in developing neurons and 4 assess the role of nuak1 in controlling its novel substrate functionally for this we will use stateoftheart techniques like microfluidic devices and deepsequencing of mrna this ambitious project aspires to describe a new cellular pathway integrating rna biology and metabolism in developing neurons and will provide the first characterization of a novel interactor of nuak1 and its control by the latter in developing neurons
niels bohr for the 21st century

niels bohr has been hugely influential both in physics and outside physics but he is also hugely misunderstood partly because a few of his writings have been overstudied at the expense of many others this erc project is devoted to his philosophical legacy and will establish an unprejudiced understanding of bohr building on a current revival of interest in bohrs ideas in the philosophy of physics and extending it among other things to his wider influence in other scientific disciplines specifically in biology and on general debates such as on science and objectivity the project will systematically exploit the resources of the niels bohr archive in copenhagen which has only recently started digitising its collectionsthis erc project has the ambition to rectify historical misjudgements and to build bridges between physics and philosophy between different schools in philosophy of physics between philosophy of physics and philosophy of biology and even between analytic philosophy and continental philosophy the relevant resources are only now becoming more widely available it is a large and methodologically novel project combining philosophy and history involving the systematic study of extensive sources and including applications to philosophy of physics philosophy of biology and general philosophy of science historically informed analysis has long proved to be an important tool in the philosophy of science and the project will lead the way in applying a historically accurate understanding of bohrs thought to 21stcentury debates
cold antiprotons for better antimatter research

the matterantimatter asymmetry is a major unsolved problem in physics why do we live in a universe dominated by matter although physics tells us that equal amounts of matter and antimatter have been created at the big bangthe aegis project at cern studies this problem by measurements of antihydrogen just last year aegis achieved the pulsed formation of antihydrogen and enters now a new era of antimatter research measuring the gravitational acceleration of antihydrogen and forming new more complex antiprotonic atoms for spectroscopic investigationhowever the sensitivity of these measurements is limited by the thermal motion of antiprotons in the case of pulsed formation of a neutral antihydrogen beam the antiproton temperature could be lowered drastically by thermalization with lasercooled ions lasercooling however has never been realized with negative ions as needed for cooling antiprotons because almost no atomic anions do have strong optical transitions suitable for laser coolingthe goal of this project is to demonstrate laser cooling of the diatomic carbon anion making it the first negative ion and the first molecular ion to be laser cooled to reach this challenging goal we will use an interdisciplinary approach making use of the complementary backgrounds of the applicant molecular physics and the host elementary particle physicsthe impact of this project goes beyond antimatter research lasercooled diatomic carbon anions can cool any other negative ion thus enabling new experiments in atomic and molecular physics or physical chemistry furthermore the transdisciplinary knowledge transfer between the host and the applicant and the bridges built between atomicmolecular physics and antimatter research will lead to new research initiatives keeping europe at the forefront of this emerging interdisciplinary field
hybrid living bioengineered hierachical constructs with selfoxygenating capability for bone engineering

tissue engineering te is a multidisciplinary field that allows the fabrication of hybrid constructs to repair replace or induce tissue regeneration cells encapsulated in 3d scaffolds have been widely employed however encapsulation limits the homogeneous perfusion of vital soluble factors and oxygen this results from the failure to stabilize a vascularised network within the scaffold and can lead to reduced cell proliferation gene expression and extracellular matrix ecm deposition with this o2cells aims to develop cuttingedge advanced devices by employing an integrative strategy with naturalbased biomaterials that combine with selfoxygenating microalgae and tissue progenitor cells in original multiscale structural arrangements that will stimulate the regeneration of highquality vascularised microtissues for this perinatal tissues will provide human structural proteins and stem cells with unique features that will be used for the fabrication of bioinks enriched with liquefied microcapsules pockets containing the microalgae and mesenchymal cells and endothelial cells huvecs these biomaterials hierarchical features and angiogenic and osteogenic potential will be fully characterized in vitro and in vivo o2cells will combine a diversity of individually pioneering concepts that could be used in the bioengineering of distinct human tissues both for therapies and for disease model development this groundbreaking concept is expected to pave the way to solve one of the significant challenges faced by in vitro bioengineered constructs and devise a broad disruptive platform for tissue engineering or other biotechnology challenges the technology developed on o2cells has the potential to be exceptionally rewarding to the scientific and medical communities which are in line with goal 3 of un 2030 agenda healthy life and wellbeing for everyone of all ages
maintenance support operation training using immersive virtual and augmented technology for efficiency with xr

xr has the potential to revolutionize various industrial sectors by offering more engaging secure and inclusive training and assistance for complex tasks thus enabling more people to acquire the skills required to perform such tasks however the creation of such xr experiences is still overly complex time consuming and expensive thus blocking their wide adoption in industrial sectors that do not have the necessary expertise nor the resources to create and deploy themthe main objective of motivate xr is to create a worlds leading xr collaborative authoring publishing and experiencing tool suite for training and assistance to industrial operations such as the assembly manufacturing maintenance and dismantlement of industrial goods this groundbreaking open tightly integrated and highly interoperable solution will be designed for and usable by a wide range of users without programming skills from the largest european industrials to handywomenhandymen without requiring software development skills it will offer an endtoend solution to streamline the whole authoring and experiencing workflow thanks to novel portable 3d scanning and digital twin modelling solutions nocode authoring approaches and groundbreaking xr experiencing tools including a nextgen european xr smart headset all assisted by the latest advances in artificial intelligence ai it will then evaluate its result in five complementary and ambitious pilots in different industrial sectors including aerospace home appliance aluminium electric distribution and hybrid humanrobot industries for this purpose our project will involve a complementary group of the bestinclass european experts and leading industries adopting a usercentric methodology coordinated by an ssh expert to ensure proper consideration of societal ethical and legal issues and ethical use of xr and ai technologies
development and demonstration of digital building logbooks

transparency and access to information are critical for the european energy efficient and sustainable buildings market construction building occupationmanagement transactions and investment and financing decisions heavily rely on transparent data availability limited information availability and lack of a common digital data repository increase costs and inefficiencies in designing constructing operating and financing buildings the ceap recognises digital building logbooks as circularity enablers and the renovation wave states that dbls will integrate all related data from upcoming building renovation passports smart readiness indicators levels and epcs demoblog brings together i 5 different dbls with a total of 45 million registered units and a wide variety of target groups homeowners municipalities building professionals and architects offering scale and diversity ii 4 diverse functionalities addressing key societal challenges ranging from quick wins renovation and advice and community driven decarbonisation pathway to complex industrial transaction objectives circularity iii partners frontrunners in rd policymaking and market implementation in highly visible platforms over the last 5 years and iv substantial opportunities to build and leverage parallel projects and activities focussed on evolvingscaling the participating building logbooks the dbls demonstrated in this project have the potential to eventually reflect the whole lifecycle with a capacity for unlimited data access input and output and data export they are also capable of embracing future technological developments such as widespread use of bim iot digital twins and blockchain demoblog has considerable potential to optimise the use of resources and waste performance prediction visual analytics and energy management contributing to the overall goal of making europe the first digitally led circular climate neutral and sustainable economy
aibased clinical software for fully automated cardiac magnetic resonance reporting

ai4medimaging is developing a disruptive clinical software ai4cmrplus for fully automated assessment of heart function and structure based on cardiac magnetic resonance cmr with the potential to disrupt the current state of art of cardiovascular disease cvd by simplifying accelerating and enhancing cmr assessment ai4cmrplus is the longsought key to unlock the full potential of magnetic resonance as routine and goldstandard heart imaging tool towards a new era of highprecision cvd diagnosis to soonerthan later gain visibility market traction and consolidate our value chain we have launched an mvp version of our software ai4cmr to the eu market early this year with eic support we now aim at accelerating ai4cmrplus development and preparing its market launch for 2025 commercial exploitation of ai4cmrplus will prompt a steady company growth strengthen the eu digital sovereignty and importantly have lifechanging impact to millions threatened by cvd
confronting thompsons conjecture a hypercontractive approach

this proposal concerns enhancing our understanding of linear algebraic group via methods from boolean function analysis in particular it is focused on addressing thompsons conjecture about conjugacy classes a longstanding problem in group theory that has captivated researchers for over four decades we bring together insights from diverse disciplines weaving together concrete conjectures concerning character value bounds the independence number of normal cayley graphs and most critically the novel concept of hypercontractivity in groups to provide a framework for a solution to the conjecture
real time molecular imager with unsurpassed resolution

over the last decades positron emission tomography pet has been firmly established as the predominant molecular imaging technique due to its unmatched sensitivity and capability to address many different metabolic processes however there is huge room for improvement as current clinical pet scanners are limited to spatial resolutions higher than 25 mm and temporal resolutions longer than 5 seconds this hampers applications of pet for preclinical research and clinical diagnosis in small tissues or lesions and precludes realtime reconstruction of metabolic images retimager is a proposal for a molecular imaging system with a tenfold spatial and temporal improvement on the reconstructed image with respect to current pet devices this will not only boost the quantitative performance but it will enable new applications in cardiology vascular oncology oncology neurology and other areas we will achieve this milestone by developing smart radiation detectors with nonconventional geometries that combine the advantages of both pixelated and monolithic detectors the two dominant and seemingly incompatible technologies employed in pet scanners our new scanner will provide 025 mm pixel resolvability with time frames as short as 001 sec by aggregating these blocks in a unique gantry selfadapting to the geometry of the fieldofview retimager will achieve an unprecedented increase in sensitivity and in in vivo realtime imaging with submillimeter resolution we will pair it with highthroughput data processing and ai tools to assess with a single tracer both perfusion and metabolism in preclinical and clinical models in the long run retimagers faster lower dose and less invasive molecular imaging technology will become a gamechanger for understanding disease processes by unveiling new accurate imagebased quantitative biomarkers taking scientific and healthcare stakeholders a step closer to personalized precision medicine