Dragon09/odtu_chatbot huggingface dataset:
bone marrowonchip as smart sensor of lung cancer relapse

in the past 40 years the overall survival rate for people affected by tumors has doubled with about 50 of patients now surviving their disease for 10 years or more nonetheless some cancers eg lung cancer still have poor survival rate a major cause of lung cancer mortality is represented by disease relapse occuring when few of the original cancer cells survive the initial treatment and causing primary tumor recurrence currently no options are available to predict the risk of lung cancer relapse which is only diagnosed late based on radiological evidence hence the ability to early detect lung cancer relapse represents an urgent and unmet need since a fast and tailored treatment could dramatically increase patients survival ratebuonmarrow lays on the groundbreaking hypothesis supported by our consortium preliminary clinical evidence that bone marrow mesenchymal stromal cells bmmsc may be educated upon cancer mediators exposure and acquire a longterm memorylike response which is amplified when exposed to a secondary tumor owing to breakthrough technologies available in the consortium organonchip innovative optical sensors and biological modeling of the bone marrow niche buonmarrow partners will develop an in vitro miniaturized bone marrow device able to harness the amplified bmmsc response generated by liquid biopsy of lung cancer patients thus acting as a biological sensor for the early detection of relapse a combination of retrospective and prospective clinical studies respectively will allow to calibrate and validate such sensor delivering an unprecedented tool to assist the decisionmaking process on lung cancer patientswe expect to significantly improve oncological treatments building on a personalized medicine approach to increased patient survival and wellbeing and thereby deeply impacting on eus socioeconomic environment
innovative polymers from tomato cutin esters monomers

the production of cutinbased polymers is currently made from acid monomers that result in conventional plastics these cutinbased plastics do not have the 3d structure of the natural cutin limiting its application polymatos project aims to develop an isolation and fractionation integrated highpressure process to obtain cutin esters monomers from tomato pomace tp to be applied as building blocks of innovative biopolymers the present proposal relates with a novel approach to the production of polyesters by addressing a key challenge in the current biopolymer research the maintenance of the flexible 3d polymeric structure characteristic of cutin in a cutinlike polyester using ester monomers instead of acid monomers this approach can efficiently increase hydrophilicity and degradability plus modulate the mechanical chemical and biological properties of polyesters the research will focus on evaluating the process conditions that would achieve cutin yields and highly functionalised building blocks in continuous microreactors polymatos has a strong multidisciplinary character since it links together biology biochemistry chemical engineering and material science to expand the application of tp to the production of an innovative polyester the proposed process will be a fundamental contribution to generating an additional revenue stream and reducing residues production in tomato processing due to the abundance of cutin the findings can be extended to other production activities benefiting the food industry and society polymatos will allow me to develop my leadership skills through innovation the project will be carried out by the experienced researcher dr aguiar at the bioeconomy research institute universidad de valladolid under the mentorship of prof cocero two secondments one at universidad de mlaga and the other one at cellmat technologies will be carried out to strengthen knowledge in polymerisation reactions and polymers characterisation
intelligent advanced photonics tools for remote andor onsite monitoring of cultural heritage monuments and artefacts

iphotocult aims to design develop demonstrate and validate innovative and intelligent solutions that will allow for noninvasive and safe ways to inspect document diagnose and monitor cultural heritage ch so as to ensure efficient adaptation of sustainable management plans these solutions comprise a a unique suite of advanced diagnostic and monitoring tools along with methodologies for their effective and optimum use combined with b an intelligent data processing visualization and prediction software services platform for the remote andor onsite monitoring of ch buildings monuments and artefacts impacted by a wide variety of environmental and anthropogenic threats iphotocult contributes significantly to the preservation of ch by adding verifiable dimensions to preservation strategies the iphotocult solutions will enable and empower ch community to better assess ch in a costeffective efficient reliable userfriendly and safe manner these solutions will revolutionize the capabilities of endusers to diagnose and continually monitor the condition of materials constituting ch including those used in their restoration iphotocult interdisciplinary approach involving many different stakeholders and ch pilots across europe will serve as usecases for demonstration testing and validation of the iphotocult solutions delivered and applied in the form of demonstrators the outcomes to a variety of ch pilots will provide crucial insights and enable the optimization of the tools and methodologies to help in the decisionmaking and serve for replication to europes ch in many in real settingsultimately iphotocult main goal is to contribute to the sustainable management of europes ch by leveraging advanced photonics technologies and intelligent software to contribute to the decisionmaking process for its preservation iphotocult aims to develop a comprehensive costeffective and scalable solution that can be deployed across europe and beyond
infrared nanospectroscopy to understand and combat alzheimers disease

neurodegenerative diseases are a ticking timebomb for health care systems because they are careintensive and will soon become much more widespread due to increased life expectancy their most common form is alzheimers disease ad in which the amyloid a peptide aggregates to amyloid fibers that accumulate in plaques in the human brain we will study unresolved key aspects of ad in order to understand and eventually combat the disease the objectives are1 to map the biochemical composition of plaques with unprecedented spatial resolution in order to understand the role of lipids in plaque organization and development possibly leading to a biochemistrybased classification of these brain lesions2 to characterize coaggregates of a with other amyloidogenic polypeptides which may link different diseases and improve diagnosis3 to improve antiamyloid peptides for a possible new ad treatment by characterizing and optimizing their interaction with a and4 to establish isotopeedited nanoscale infrared ir imaging as a versatile tool to characterize chemically similar components of mixtureswe will exploit the advantages of novel approaches in ir spectroscopy to move the field forward in areas that are difficult for more common methods ir nanospectroscopy with 20 nm spatial resolution will be used throughout and will be combined for the a studies with isotopeedition and with fourier transform ir spectroscopy the supervisor is a wellknow expert in biological ir spectroscopy and has recently established all approaches in his work i as the researcher will be trained in advanced ir spectroscopy as well as in transferable skills incl leadership and in pedagogics the expertise in ir nanospectroscopy will particularly promote my career because the technique is about to revolutionize chemical imaging and has many applications in basic and applied science for the same reason also the eu will benefit from additional experts in this technique
engineering of superfluorescent nanocrystal solids

the time is right for lightemitting colloidal nanocrystals to meet the demands of the second quantum revolution the cooperative emission superfluorescence was recently observed in the micronsized solids of colloidal lead halide perovskite nanocrystals offering a path to lowcost solutionprocessed sources of bright and coherent light superfluorescence characterized by highintensity and ultrashort bursts of indistinguishable photons makes nanocrystal solids desired targets for photonics and quantum information applications however the exact origin of the superfluorescence is debated and the rules of nanomaterial design for ondemand cooperativity are unknownprometheus tackles these issues by combining nanochemistry with spectroscopy and tools of quantum optics the projects approach consists of 1 synthesis and judicious selection of emissive metal halide nanocrystals with minimal exciton energy inhomogeneity 2 accelerated selfassembly of nanocrystals into binary solids with a tunable fraction of emitters 3 cryogenic microphotoluminescence spectroscopy at the level of individual nanocrystal solids the control of the coupling between emissive nanocrystals is achieved by diluting opticallydense nanocrystal solids with a second transparent nanocrystal component measurements of spectroscopic observables coherence and photon statistics on single nanocrystal solids are used to dissect the roots and properties of cooperative emissionthe project introduces a concept of lightcoupled nanocrystal solids where lightmatter interactions are engineered through structure and composition this concept goes beyond metal halides and applies to emissive nanocrystals of any shape opening a class of colloidal nanomaterials with light emission controllable between singleparticle and manybody regimes such materials are expected to expand applications of emissive nanocrystals in quantum technologies and yield new uses in materials science
multiscale hierarchical imaging of the spiraled structure of narwhal tusk

narwhals are mysterious animals that have fascinated humankind since ancient times they are known for their unique spiralled tusks which made people believe in the existence of unicorns for centuries the up to 3 m long straight tusk displayed by males always has a lefthand spiral macrostructure making it unique in the animal kingdom very little is known about these fascinating animals and the reason origin and biological structure of their tusk is a great question mark among marine biologists and biomaterial scientists in the proposed project we will aim to reveal the hierarchical structure and biomineral characteristics of this unique biological material their tusk for that purpose we will employ a combination of recently developed 3d xray imaging techniques in a hierarchical approach studying their nano micro and macrostructure with xray computed tomography xray diffraction and xray small angle xray scattering novel imaging techniques using synchrotron radiation like tensor tomography will reveal the structural organization and anisotropy of the tusk building blocks and diffraction computed tomography will provide very valuable information about the biomineral phase in the tusk and teeth the multilength scale approach explained in this project will be a pioneer in the field and we expect to establish a new methodology for a more complete structural characterization of biological and composite materials all that will be implemented and developed in the 24 months of the project which compiles 4 experiments in largescale synchrotron facilities data analysis strategies development and the establishment of a complete multiscale model of the narwhal tusk biological structure
how genetic constraint and selection drive colour diversification reconstructing the evolutionary history of sexual dichromatism in island endemic lizards

how genetic architecture and selection jointly contribute to evolution is central to understanding the striking diversity of colours and patterns in nature yet major questions remain do novel colour variants appear gradually or in jumps can evolution of sexual signals proceed independently of colours used for crypsis can evolution modify male colouration independently of the colour of females and vice versa answering these questions requires the integration of highly multivariate data on colouration and ecological data as well as information about the underlying genetic relatedness between populations and lineages in particular rapid diversification of coloration between lineages of the same species can put the role of genetic constraint and selection in evolution to the test this project will be novel in studying these factors simultaneously across an extraordinary radiation balearic wall lizards podarcis pityusensis and podarcis lilfordi these lizards exhibit a striking variation in colouration between lineages isolated on more than forty islands in the balearic islands spain in this project i will i reveal the evolutionary history of balearic wall lizards ii establish if genetic constraints bias evolutionary change by reconstructing evolutionary transitions in body colouration between males and females ie sexual dichromatism and iii put to the test the role of sexual and natural selection for evolutionary change in male and female colouration this will offer genuine insights into the origin and evolution of colour diversity and help to resolve how the diversification of colouration is shaped by genetic constraints and sexual and natural selection complementary this project will provide a wealth of information eg molecular morphological ecological about two endemic species currently facing a decreasing population trend
a native mass spectrometry systemic view of cellular structural biology

protein structure and consequently function is influenced by the cellular content the array of splice variants posttranslational modifications cleavages and the ability to bind cofactors and drugs is governed by the surrounding cellular milieu this is determined by internal and external cues such as cell type developmental stage stress conditions disease and aging which give rise to an ensemble of distinct protein entities to study this diversity there is a need for methods that enable structural studies under closetolife conditions maintaining the natural environment and biological diversity features that are often lost during biochemical purifications our recent discovery that native ms can be conducted within crude cellular lysates directms while preserving the biological context offers many new experimental avenues for investigating protein interactions and diversity here we propose to take native ms to a new dimension enabling a systemic view of cellular structure biology by endorsing technological computational and methodological developments to do this we will i establish a platform for highthroughput screening of protein interactions ii unravel protein interactions in human and other eukaryotic cells iii develop a method for wholeorgan directms analysis unravelling the tissuespecific proteoform landscape each of our three independent but complementary aims involves a different biological system going from bacteria through human cells to intact tissues together these advances in conjunction with the highresolution and sensitivity afforded by current mass spectrometers has the potential to advance a plethora of fields including cell biology pharmacology and biotechnology overall we anticipate this project will promote the integration of directms into the cellular structural biology toolkit providing valuable insights not attained by other structural biology methods or artificial intelligence algorithms
european tidal energy pilot farm focused on industrial design environmental mitigation and sustainability

there is 10gw of predictable highvalue tidal stream energy potential in european waters with up to 100 gw of capacity globally this is an almost entirely unharnessed clean energy resource with just 13 mw currently deployed transitioning european market leading technologies from single deployments up to farm scale is the next milestone in harnessing this clean predictable secure domestic energy resource eurotides has been developed specifically to address the call topic by delivering a 96mw farm of four 24mw orbital tidal energy devices of the same series the farm will operate in full operational conditions for 15 years deploying in 2027 the eurotides consortium will work collaboratively to deliver six ambitious objectives and drive the sector forwards1derisking tidal energy technology development by delivering a 96mw pilot farm and three pilot farm system innovations reducing levelised cost of energy lcoe of orbitals floating tidal technology from 120mwh to 100mwh2increase bankability and insurability by providing 17520 hours of operational data displaying the production of 50gwh and verification of key technology metrics to internationally recognised methodologies reducing cost of capital from 1012 to 563increase availability of tidal stream by creating an efficient robust replicable and reliable operations and maintenance programme increasing availability to 954improve market confidence by developing industrial design and manufacturing processes increasing supply chain capacity from one device per annum to 80 devices per annum5increase knowledge of environmental impacts to ensure appropriate environmental protection and mitigation is in place enabling safe scalability to a 100gw global market6making performance reliability and behavior data collected from the demonstration publicly available accelerating scalability commercialisation and deployment of a 2gw project pipeline
internal and international climateinduced migration gendered inequalities and governance understanding migration decisions exploring migration experiences

the world bank estimates that climate change will force 216 million people to leave their homes by 2050 using un data the australian think tank iep calculates that 12 billion people risk being displaced by 2050 because of ecological threats beyond alarmist projections of which we need to be wary and as a matter of fact we know little about the articulation of internal and international climateinduced migration because once those on the move cross borders they become labour migrants asylum seekers or undocumented migrants with climaterelated causes rendered invisible in the absence of any internationally recognized status for climate migrants it remains unclear what proportion of international migration flows are also caused at least partially by changes in peoples natural environments that relate to climate change importantly we know even less about the gendered inequalities that permeate these forms of mobility to fill this crucial gap genderedclimatemig explores climateinduced internal and international migration and their articulation from a gendered perspective and through an interdisciplinary comparative and participatory methodology this project will produce highly informative ethnographic casestudies in 3 middleincome countries and regional migration hubs mexico morocco and malaysia along with a multisited and gendersensitive enquiry into the current state of climate migration governance at international eg platform on disaster displacement and national levels exploring original national policy initiatives eg in norway peru and kenya the qualitative and participatory methodology of this research promises to lend unique insights into the decisionmaking processes trajectories and lives of climate migrants through a gendered lens genderedclimatemig will advance our understanding of the underresearched climatemigrationgender nexus while carving out more space for migrants voices
fair to adapt to climate change

the fair2adapt is a multidisciplinary project geared towards transforming data into actionable knowledge to shape climate adaptation strategies by leveraging and collaborating with eosc we fully tap into the eoscs wide range of services the fair implementation framework catalogue of resources and align with the eosc interoperability framework we adopt fair digital objects fdos by using rocrate and nanopublications as key implementation tools we use semantic bridging strategies such as the iadopt framework and tailored fdo services to build a collaborative userfriendly fair and open data sharing framework rich case studies will codevelop fair supporting resources in alignment with the fairification framework and demonstrate the impact of fair and open data sharing on climate change adaptation and strategically support the eu missions objective of enhancing climate resilience in european regions and communities through transfer cases and collaboration with other initiatives fair2adapt extends its reach to additional contexts showcasing its scalability sustainability and applicability beyond the projects completion a significant aspect of the fair2adapt project is stakeholder engagement and capacitybuilding activities which will be instrumental in raising awareness and devising customised solutions by transforming data into flexible practical and resilient climate adaptation strategies fair2adapt constructs a scalable and extensible model for data sharing that can be adapted to multiple climate adaptation scenarios the impact of fair2adapt will span across scientific advancement economic resilience socialenvironmental wellbeing and responsive policy development fostering multidisciplinary cooperation enhancing trust in science and stimulating a climatesmart economy ultimately fair2adapt intends to build a more resilient inclusive and knowledgebased society capable of efficiently tackling the challenges of climate change
the eye as a window to the brain

nocturne gmbh founded in 2018 is a spinoff from the charit universittsmedizin berlin germany developing software solutions to efficiently process retina image data for neurological applications at scale across devices using advanced aibased analysis the innovative and unique technology developed tackles one the current major challenges in healthcare the rapidly increasing burden of brain diseases with the increase of life expectancy and aging population neurological disorders are the leading cause of disability and the second leading cause of death worldwide the greatest unmet needs are better faster and more costeffective diagnostic and monitoring tools that could be widely available and have the potential to detect these diseases at the earliest stage in order to delay disability and provide each patient with a personalized treatmentto address this the team of nocturne identified two major opportunities the use of the retina as a window to the brain and an already established on the market hardware imaging technology costeffective widely available with no burden for the patient that can capture retinal images in less than 5 minuteswith its product nocturne addresses customers in pharmaceutical research academia and clinical care in germany alone more than 1 million patients suffer from relevant diseases like multiple sclerosis parkinsons disease and others we estimate the annual market volume in germany alone at 350 million in europe at 2 billion at market entry nocturne product is a cecertified local installable web service which accepts data from standard retinal imaging devices the data are then analyzed with nocturnes technology and a report is generated for the physician the pricing is based on a payperanalysis a model commonly used for example in radiologyour focus is by removing the technical barriers and by providing unique insights into the diseases to enable better disease management and patient care