Dragon09/odtu_chatbot huggingface dataset:
science platform cloud infrastructure for outsize usage scenarios

the spacious project aims to boost the scientific exploitation of esa mission data by offering a new computational framework for astrophysical research that requires big data and data mining technologies to be employed spacious will raise the competitiveness of the eu scientific community by increasing the big data and data mining expertise and providing easier access to these techniquesto reach this goal spacious aims to combine existing technologies in a new data mining environment to enable the analysis of esa missions data up to a level which is not possible without a dedicated infrastructure the ambition of spacious is to open this platform to the community while at the same time exploiting the data by developing astrophysical research in collaboration with external scientific teamsthe main idea is to facilitate and open the analysis of esa archives to the scientific community in new ways spacious will make the difference by providing access to the data and at the same time providing the infrastructure tools and methods to analyse these data spacious will be the tool enabling big data analysis of esa data products furthermore we expect spacious to make a change by influencing the future way to treat data in space sciencea key part of the project is to produce scientific value publications enhanced data products and knowledge we will face major scientific research data problems challenges whose analysis will be per se a key result of spacious four of these challenges will be defined internally based on the exploitation of the massive gaia and euclid datasets and used to drive the design requirements of the system serving as test cases and technology demonstrators of the big data analytics framework bdaf in a second phase we will open the system to the community through an open call for proposals and will select the most relevant both scientifically and technically challenges submitted for their implementation
support to the vicepresidents of the erc scientific council 20212022

the european research council erc provides a competitive platform for investigatordriven frontier research at the european level it is led by a scientific council scc consisting of 21 eminent scientists and their president and it is this council that independently establishes and oversees the ercs scientific management and the implementation of its work programme this project aims to support the erc vicepresidents who act on an honorary basis in the efficient and timely achievement of the sccs goals in 2021 and 2022 this project will provide local administrative and advisory support to the three erc vicepresidents the staff supported by this project will provide analysis of the output of the erc and the scc to the vicepresidents preparatory work for the meetings of the scc support with scientific outreach and representation as well as maintaining a clear and efficient channel of communication between the vicepresidents and the ercs executive agency a key duty of the vicepresidents is maintaining the integrity of the ercs evaluation panels and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the vicepresidents to allow them to take informed decisions on recruitment the staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process the impact of the project will be to ensure the efficient and wellmanaged operation of the scc this support is required as the duties of the vicepresidents demand a considerable portion of their time by allowing the vicepresidents to effectively and efficiently perform their duties this project will contribute significantly to the continued implementation of the erc under horizon europe
chimeric antigen receptor car t cell therapy for solid tumors

cartuning will assess the technical and commercial feasibility of an improved and broadly applicable chimeric antigen receptor tcell cart approach based on a novel implemented mechanism of action there is an urgent need for more effective treatment strategies against cancer which remains the leading cause of death worldwide immunooncology regimens such as immune checkpoint blockade therapy ict and cart therapy emerged as powerful tools in cancer treatment however in the majority of patients these fail to achieve longlasting therapy response further they remain costly and applicable to a limited range of cancer types specifically cart therapy faces two unresolved challenges 1 limited therapy persistence 2 tumorinduced immunosuppression consequently no cart therapy against solid tumor cancers has reached the market prof gottfried baier has uncovered that inhibition of orphan nuclear receptor nr2f6 a downstream target of t cell antigen receptor signaling intermediate pkc overcomes these shortcomings in a twofold manner 1 increased therapy persistence to improve its longlasting effects 2 reduced immunosuppression at the tumor site to improve immune response within this erc poc first we will technically validate this approach using in vivo mouse and ex vivo patientderived tumor models we will focus on nsclc as first indication as it is one of the mostdifficult to treat solid cancers with high mortality rate and disease burden subsequently commercial feasibility will be determined by verifying ip position and strategy performing indepth market and competitor analyses and finally consolidating these into a business plan to establish the best path to commercialization successful commercialization of cartuning would reduce the socioeconomic burden of nsclc extending and improving patient lives and enable the development of longlasting costeffective cart therapies applicable to a greater range of cancer types
widening synergies for novel enzymes development

the widening synergies for novel enzymes development widenzymes project aims to foster the creation of a unique crossborder collaborative ecosystem devoted to advancing enzyme technology in the eu this endeavor follows the wellestablished profiling regional innovation ecosystems methodology and centers its efforts on two key domains joint internationalization and inclusive talent development through the implementation of strong synergies within the consortium beneficiaries will be able to both enhance their potential and increase the impact of their research projects significantly sharing competencies and stateoftheart equipment will allow the beneficiaries to increase their critical mass and scientific excellence and therefore to compete in horizon europe calls with european countries whose ri potential is traditionally more established the inclusion of two nonwidening partners one academic and one sme with strong expertise in innovations exploitation large publicprivate partnerships and different eu funding applications is a key accelerator factor to elevate the consortiums preparedness and competitiveness it is envisioned that the vigorous training and student exchange program implemented by widenzymes will attract students and young researchers alike thus allowing the creation of a highly educated and competitive workforce that can tackle ambitious research projects and secure funding at the european level the widenzymes project seeks to bridge borders and boundaries in the pursuit of cuttingedge enzyme technology by fostering collaboration leveraging funding opportunities nurturing talent adopting a multisector approach and enhancing visibility we aim to propel enzyme technology to new heights through these endeavors we aspire to make a lasting impact on science industry and the society at large
scalingup superlubricity into persistence

friction between moving parts and the associated wear are estimated to be directly responsible for 25 of the worlds energy consumption sslip seeks to establish a radically new way to drastically reduce friction with potentially enormous technological and societal impact the driving concept is structural superlubricity extremely low friction that takes place at a lattice misfit between clean flat rigid crystalline surfaces structural superlubricity is currently a lab curiosity limited to micrometer scale and laboratory times sslip will bring this to the macroscale to impact reallife products the key idea is the use of tribocolloids colloidal particles coated in 2d materials that will produce a dynamic network of superlubric contacts structural incompatibility between arrays of colloids allows us to replicate the low friction on bigger length scales and overcome the statistical roughness of real surfaces we will leverage our breakthrough result to regenerate the 2d coatings themselves during sliding through careful design of these coatings carrier fluid and the mechanical properties of the core particles the chemistry of sliding and collective behaviour of the colloids can be controlled synthesis and experiments of individual contacts will be combined with visualisation of colloid dynamics during sliding on larger scales and insite chemical characterisation these will be combined with multiscale simulations and theory to bridge the different length scales into a coherent framework the developed ultralow friction technology will drastically reduce loss of energy for example in passenger cars responsible for around 2 billion tonnes of co2 per year and increase the lifetime of parts it will also enable radically new technologies that are impossible with current lubrication thus paving the way for eg much higher writing speeds in harddisks where the writing tip will be able to move in full contact with the disk
targeting amino acid uptake into nk cells to limit pathogenesis in sepsis

sepsis is a global health challenge accounting for around 20 of deaths worldwide while sepsis is induced by uncontrolled dissemination of infection significant contribution to disease pathogenesis is made by overwhelming production of proinflammatory mediators a socalled cytokine storm there is a pressing need for new target therapies to dampen this immunopathogenesis while still allowing bacterial clearance although natural killer nk cells are vital for host innate responses they are important contributors to the tissue damage during bacterial sepsis in particular via production of excessive amounts of ifng therefore dampening nk cell ifng production represents a promising tool for sepsis treatment recent studies from the host institution have shown that metabolic processes are essential for nk cell functions in particular certain amino acid transporters are key to support ifng expression by nk cells i thus hypothesize that limiting amino acid supply to nk cells will restrict production of ifng dampen the cytokine storm and improve the course of bacterial sepsis to prove this idea i will combine my experience in mouse models of septic shock with host institutions background on immunometabolism and bacterial infections first i will employ a powerful metabolic toolbox established at the supervisors lab to characterize metabolic phenotype of nk cells in bacterial sepsis next i will use mice with genetic ablation of key amino acid transporters specifically in nk cells to study their role in cytokine storm during sepsis finally i will test pharmacological compounds able to limit amino acid availability for their potential to prevent excessive inflammation during sepsis at the end of the project i will acquire key professional skills including metabolic toolbox and bacterial infection model that will benefit my further career as well as characterize new potential therapeutic opportunity for treatment of sepsis
multilevel approach for the upscaling of ultra high temperature energy storage and conversion

the growing interest for the integration of renewable energy sources as solar energy in the global energy mix increases the need of developing of new methods that will assist on the upscaling and demonstration of efficient energy storage and conversion technologies in this regard advanced modelling methods can be an indispensable tool towards this effort shine aims at developing a holistic numerical methodology by using inhouse codes coupled with commercial software that will boost the costefficient and sustainable electricity production and storage at unprecedented ultrahigh temperatures 1000 oc the stepping stone for the modelling activities will be a compact latent heat thermophotovoltaic device recently patented in upm targeted for energy storage and production at ultrahigh temperatures the core components in such a device are the latent heat thermal energy storage system and the thermophotovoltaic device the modelling methodology will integrate rigorous multiphysics models fluid dynamics heat transfer and optoelectronics targeted at a component level into a reduced order model rom by using multivariable polynomial functions key in the proposed methodology is the validation of the rigorous models through inhouse measurements at ultrahigh temperatures that will be undertaken at the host organisation key as well is the production of the multivariable polynomials through artificial neural networks that will be undetaken during the secondment phase the whole project is highly interdisciplinary because it integrates highly interrelated diverse disciplines physics engineering optoelectronics thermo and fluiddynamics photovoltaics and thermal storage and artificial intelligenceai as well as knowhow from experiments is a single holistic approach once developed the rom will be used to predict the whole systems performance as being part of a solartoheattopower and a powertoheattopower concepts
scaling the societal impact of community enterprises for sustainability

how can community enterprises scale their impact and reshape society beyond markets and states this is an important and timely challenge in realising societal transformations for sustainability as scholars and policymakers have recently placed high expectations on the transformative potential of communities while community enterprises are widely known to foster collective action locally the mechanisms through which they can achieve wider transformations to tackle urgent sustainability challenges such as climate change are poorly understood scensus aims to identify and understand the mechanisms by which community enterprises can scale their societal impacts it will analyse initiatives in three key fields energy carsharing repair in germany france the uk and the netherlands to 1 develop a unified theory that explains the factors behind the scaling of community enterprises 2 analyse the institutional complexity arising as community enterprises scale and the collective mechanisms to manage them 3 identify and analyse community enterprises strategies to mobilise critical resources and build legitimacy for scaling 4 understand the roles of social networks in community enterprises scaling dynamicsthis research will 1 advance collective action theory with key insights from social network theory and organisational institutionalism 2 create a novel approach to scaling beyond business growth in single organisations and market diffusion 3 connect different levels of analysis from community enterprises internal functioning to their aggregate development 4 develop and test an innovative multimethod research design combining largen statistical analysis surveys and comparative case studies to capture dynamic scaling processes by creating a new interdisciplinary theory of the dynamics of community enterprises within wider social systems scensus will advance the research frontier on collective action and organisation studies
unveiling gravitational waves from galactic nuclei

to date the mechanisms that trigger the formation and gravitational wave gw coalescence of compactobject co black holes neutron stars white dwarfs binaries are still unknown two main formation scenarios have been proposed primordial and dynamicallyformed binaries but both appear in tension with data galactic nuclei are a promising nursery for gw merger events because of their high stellar density and the presence of a central massive black hole mbh numerical simulations represent an ideal tool to model cos in galactic nuclei but the current literature misses several key features which are needed to fully capture the complex physics involved the gwnucleus project aims at filling this gap by answering to the question how do galactic nuclei shape the properties of gravitational waves gw sources i will achieve this goal by developing an innovative hybrid montecarlonbody model for simulating cos in galactic nuclei at the theoretical astrophysics group of the niels bohr international academy nbia led by prof martin pessah this novel framework will finally provide a complete understanding of gw progenitors evolution in galactic nuclei and establish a new theoretical model to interpret present and predict forthcoming gw observations
next generation of over 25mw offshore wind turbine rotor design

the rated capacity of offshore wind turbine owt will increase continuously exceeding 25mw over 300m rotor diameter in the next ten years based on the current owt industry design trends however there are no extant studies investigating the limits of current technologies and theories to design and analyse very large owt systems furthermore it requires further development of simulation tools control concepts and design and operation methods another important aspect of designing very large owt rotor is the need for highly skilled human resources for this transition indepth knowledge and crossplatform training are needed to train a pipeline of young engineers for the highvalue jobs supporting the wind turbine system original equipment manufacturers oems and wind farm development and operating industry it is the main reason we design a doctoral training network nextgent consists of worldleading academic beneficiaries and worldleading wind industries and research institutions as associated partners from different countries to provide the highly trained 11 phd fellows with both continuous and discrete customized training activities through networkwide and jtn training events the training program will be completed by secondments to encourage complementary technical exchanges and human mobility nextgent focuses on the four most important elements to design over 25mw 25mw owt rotor systems 1 wind characteristics and resources 2 aerodynamics 3 structures and 4 aeroelasticity the fellows will undertake individual projects in these areas all the research questions in the project reflect industry needs academic novelty and innovation will be reflected in the methodologies and solutions the research results will be disseminated directly to the public and scientific community the outcomes are both technologies and a talent pool to accelerate the next generation of largescale offshore wind power
mechanical stability of phospholipids bilayers in the presence of microplastics

in recent years the number of microplastics plastic particles smaller than 5 mm in the environment has exploded and is expected to continue to increase in the coming years they are now found in the air we breathe in drinkable water in food and even in human blood or organs unfortunately this pollution issue is accentuated by the environmental contamination with perfluoroalkyl and polyfluoroalkyl compounds pfas known as forever chemicals and linked to cancer problems these chemicals are also found everywhere up to the human body and tend to adsorb on plastics however the understanding of the interaction of pfas or microplastics with complex shapes sizes and chemical compositions on living systems is missing metabolism seeks therefore at adapting physicochemical and biophysical techniques and models to understand the adsorptionattachment of these systems the stretching dynamics and the unzipping mechanism of lipid bilayers mimicking cell membranes in the presence of contaminants the project aims at developing an integrated platform to simultaneously image and measure the stress distribution within the bilayers and the adhesion forces at play in order to quantify the dysfunction of the cell machinery the stability of lung cells will also be probed to have new insight into the damaging induced by pollution on relevant living systems gaining understanding about this problematic will provide important new knowledge on the impact of contaminants on health and highlight the need to improve remediation strategies
impacts of metal and climate change on nutrient cycling in the rhizosphere of phytoremediating plants

at a global level the management of contaminated sites including soils is gaining relevance in environmental and political agendas metal contamination in soils poses an important risk to environmental and human health even though research on metal contamination has received plenty of attention over the last decade major knowledge gaps exist about the impacts of metals on nutrient cycling processes even less is known about the coupled effects of metal contamination and climate change conditions on phytoremediation efficacy and associated nutrient dynamics in the soil the nutclime project impacts of metal and climate change on nutrient cycling in the rhizosphere of phytoremediating plants aims to disentangle the interplay of nutrient dynamics and soil microorganisms in the rhizosphere of metalhyperaccumulating plants used for metal extraction under today and future climate conditions this will be accomplished by studying a model plant for metalhyperaccumulation arabidopsis halleri plants will grow in rhizoboxes and in fully controlled greenhouse chambers with temperature and co2 concentration based on todays and the ipcc rcp 85 scenario climatic conditions the combination of isotope pool dilution assays with transcriptomics will allow to assess how metal contamination and climate change affect key process rates in nutrient cycling and its linkage with the active microbial community composition in the rhizosphere the integration of zymography pore water sampling xrf elemental mapping and gene amplicon sequencing analysis will elucidate the interplay of roots and soil microorganisms in the spatial distribution of nutrient cycling enzymes and the availability of metals and nutrients the outcomes of this project are also expected to provide valuable information about how nutrient fluxes are primarily affected and are limiting plant growth and metal accumulation which may be helpful to improve phytoremediation and phytomining