Dragon09/odtu_chatbot huggingface dataset:
developing a novel parkinsons disease drug using small molecule mimetics of glial cell linederived neurotrophic factor gdnf

genecode is developing a novel antipd drug that contains a central nervous system penetrant compound imitating gdnf peptide pathway activation that alleviates both motor and nonmotor symptoms in pd patients protecting and restoring lesioned dopamine neurons as well as potentially increasing dopamine levels in brain tissue genecodes unique solution uses smallmolecule compounds that penetrate the bloodbrain barrier target the gfl receptor complex containing gdnf protein and mimic gfl gndf family of ligands biological effects in neurons promoting survival in the affected dopaminergic neuronal pathways once fully developed the pd drug would be administered weekly or less frequently as an oral treatment considering the importance of gdnf family ligands andor retsignalling pathways for other groups of cells applications of compounds developed by genecode are not limited to pd but can be applied to cure other medical conditions such as neuropathic pain addiction als etc
dynamical systems and reaction kinetics networks

the primary goal of the project is to advance the theory of dynamical systems governed by differential equations with multiple parameters leveraging this enriched understanding to dissect mathematical models that mirror realworld phenomena and processes our exploration will span both qualitative and quantitative attributes of these systems including their general structure solution properties bifurcations stability etc in a practical application of our theoretical insights and computational techniques we will delve into the analysis of certain biochemical networks with a focus on those integral to reaction kinetics employing a synergistic approach that melds symbolic and numerical computation we aim to enhance the analysis of stability and bifurcations within intricate biochemical systems this will be achieved by developing bespoke symbolicnumeric tools designed to uncover instances of multistability and bifurcations our qualitative and computational evaluations will serve dual purposes elucidating established biological phenomena and forecasting emergent onesadditionally our research will extend to the emphasizing parameter estimation and the resolution of control dilemmas for biomedical applications we will explore novel territories of positive and impulsive control areas currently lightly tread in existing literaturethis project is inherently interdisciplinary seeking to fuse and expand upon the methodologies from mathematics applied mathematics and reaction kinetics alongside the computational algorithms of symbolic computation incorporating the principles of the green charter our research will also emphasize sustainable practices and the development of simulations aimed at addressing and mitigating environmental impacts associated with the processes under study furthermore this endeavor promises substantial training opportunities for earlystage researchers fostering an environment conducive to learning and innovation
uncovering the biological relevance of the replicationassociated protein splicing during viral replication in geminiviruses and other cress viruses

due to their limited proteincoding capacity viruses have evolved sophisticated mechanisms to hijack the host molecular machinery for their own benefit among these strategies splicing of the viral transcripts allows them to increase their transcriptome and proteome diversity and has been described in several virus families including plant dna viruses such as geminiviruses geminiviruses which cause devastating problems for the agriculture worldwide belong to the circular replicationassociated protein repencoding cress viruses a phylum infecting organisms from all three domains of life and potentially sharing analogous mechanisms for genome replication importantly rep is the only protein required for viral replication and is structurally conserved across cress viruses splicing of rep transcripts has been anecdotally reported in circoviruses and a few minor genera of geminiviruses with some splicing events required for a full infectivity on the other hand unpublished work in the host group has uncovered that i rep from different begomoviruses the major genus within the geminiviridae family associate with the plant splicing machinery and ii tomato yellow leaf curl virus tylcv rep transcripts are spliced during the infection giving rise to at least five unknown rep protein isoforms lacking either the oligomerization domain or part of the nterminal dna binding domain we propose to uncover the importance of rep splicing in tylcv and to establish its relevance during the viral replication by characterizing rep spliced variants interactome and functions we will also analyze the conservation of rep splicing landscape in different geminiviruses and cress viruses potentially outlining an unknown layer in the regulation of the replication of these crosskingdom infecting viruses
do mountain plant responses to climate change depend on microbial mutualists

plant interactions with microbial mutualists are critical for plant growth with mutualists enhancing plant access to essential nutrients and ameliorating the effects of stressful environmental conditions such as extreme temperatures and drought as a result microbial mutualists may play an important role in mediating plant responses to changing climates the goal of this project is to elucidate how interactions with microbial mutualists shape plant distributions and communities in response to climate change in mountain grassland habitats my project builds on recent advances in monitoring techniques like edna metabarcoding to characterize microbial communities at large scales allowing for detection of patterns in the relationships between environmental drivers plant community composition and microbial mutualist communities the novelty of this project lies in the combination of this type of data with an experiment manipulating microbial mutualists which is essential for identifying the causes underlying observed patterns specifically i aim to 1 determine variation in plant species responsiveness to mutualists with and without drought stress 2 examine whether mutualistresponsiveness predicts plant distribution responses to drier warmer climates and 3 model both direct effects of climate on plant community structure and indirect effects via microbial mutualist communities that are affected by climate and interact with plant communities in addition to advancing our understanding of how microbial mutualists shape plant communities this project will facilitate knowledge transfer between me and my host institution i will receive training in research areas such as advanced statistical modelling and edna metabarcoding techniques and analyses while sharing my expertise in the ecology of plantmicrobial mutualist interactions
circular cities and regions initiative ccri coordination and support action csa

the ccri csas goal is to strengthen and complement the ccri in order to foster the implementation of circular systemic solutions css in european cities and regions based on an initial scoping and needs assessment the csa will set up an expert team to support thematic working groups twgs and provide complementary technical assistance to ccri cities and regions during the duration of the project the csa will also deepen the ccri knowledge on circular economy with the production of highly impactful case studies on css a series of white papers on key research innovation ri gaps guidance documents for practitioners at the local and regional level as well as recommendations for eu and national policy makers to unlock barriers faced local and regional authorities by establishing a series of mechanisms such as including webinars study visits and a twinning program the csa will stimulate knowledge transfer pear learning and capacity building towards an audience of cities and regions including but not limited to ccri pilots and fellows all dissemination and communication activities will use the ccri existing umbrella identity and existing communication channels the csa will endeavour to strengthen links with the european ecosystem and to promote the circular economy towards all european cities and regions those activities will be done in close coordination with the ccricso and dg rtd to take advantage of potential synergies and importantly to prevent any overlaps and duplications with the work of the cso led by iclei europe the csa brings together 11 leading organisations active throughout europe and with considerable expertise and experience in supporting cities and regions sustainability transition
contraband the only heart failure medical device that is placed outside the heart

worldwide 26 million people suffer from congestive heart failure chf a chronic condition that worsens with time and leads to staggering healthcare costs and a significant reduction of quality of life contraband is an implantable device aiming to restore heart function in patient suffering from left ventricle failure contrabands benefits include builtin failsafe for full reversibility of functionality tremendous ease of use due to its proprietary stntwithinastnt design and transcatheter delivery system and full clinical flexibility to be compatible with pharmacotherapies and other chf devices in the project we will finalise clinical development and introduce contraband into clinical routines in europe we expect to launch contraband in 2024 generate 15m in revenues in 2025 and 60m in 2026 before market launch we will create 95 jobs at the company in strategic locations in europe
adaptation strategies for the elderly in multidomain indoor environments wellbeing and building energy consumption

europe faces significant challenges such as an ageing population shortage of energy and climate change as elderly peoples physical and adaptive abilities decline their needs for health and comfort in the indoor environment rise the gradually expanding elderly population may result in increased building energy consumption and a higher carbon footprint however indoor comfort standards are usually targeted at healthy young populations and address singular domain environment little knowledge is in the literature about how to balance wellbeing and energy consumption in multidomain indoor environments thermal visual acoustic and indoor air quality for older adults this knowledge gap has motivated ageadapt we aim to improve wellbeing and minimize energy consumption by comprehending the adaptive cycles for elderly people in the multidomain indoor environments enabling us to propose adaptive strategies a threestage hierarchical research methodology combining living lab experiments with fixed and adjustable environmental conditions and field investigations will be created allowing to 1 assess the effects of multidomain indoor environments on the physiological behavioural and psychological adaptation of older adults 2 assess the role of physiological psychological and energy consumption benefits after behaviours have occurred 3 create models evaluations and strategies for adaptive comfort in indoor multidomain environments for older adults at different health levels the impact of ageadapt on the scientific community industry and the general public will be significant and sustainable it will offer input into the establishment of indoor environmental design standards and behavioral adaptation guidelines for elderly people drive the development of products for indoor environmental comfort and health management and contribute to the goals of healthy aging and climate neutrality
frequencyagile integrated photonic light sources across the visible and nearinfrared spectrum

lasers are ubiquitous in science and technology with applications ranging from optical communications and quantum technologies to metrology and sensing and to life sciences and medical diagnostics however most commercially used lasers are still based on legacy optical schemes these devices are either bulky and expensive limiting product development or lack the ability to quickly sweep or precisely control the laser wavelength which is key to many applications at the same time the advent of advanced photonic integration platforms such as silicon photonics has opened new perspectives realized only for exascale data centers in telecommunication wavelengths around 1310 and 1550 nmagilight aims at establishing a new class of integrated lasers that can address the entire wavelength range from the blue 400 nm to the infrared 27 m these devices rely on a hybrid integration platform that combines ultralowloss silicon nitride photonic circuits with advanced tuning actuators and with iiiv gain elements exploiting highly scalable assembly concepts based on 3d printing the devices will offer high output powers 100 mw down to hzlevel laser linewidths and unprecedented frequency agility with nanosecond response times and wideband tunability comprising leading european research groups and hightech startups as well as a major industrial player agilight will translate groundbreaking research to rapid technology uptake and tailor laser systems for atomic and molecular physics and optics distance ranging and sensing using the expertise of endusers the project covers the theoretical and nanofabrication foundations of the envisaged light sources as well as their implementation and functional demonstration in highly relevant research applications throughout the visible and nearinfrared spectrum agilight will lay the foundation for an alleuropean value chain of a novel class of light sources covering the iiiv and lowloss pics
production of a new biodegradable bioplastic made up of biomolecules extracted from expired milk

the global plastic production reached up to 448 million tons in 2018 of which approximately 8 million tons are entering into the oceans every year the imprudent use of plastics in our everyday life elevated plastics into the major pollutant component of the world seas and oceans at the same time every year in europe 36 million tons of milk are thrown away as waste splastica is an innovative startup and a spin off from university of rome tor vergata founded in 2019 whose ceo is a woman which found an innovative way to turn expired milk into a biobased and biodegradable plastic by means of a patented process this bioplastic has been widely characterized showing good hardness resistance and great stability in a wide range of temperatures and in contact with food water detergents the singleuse plastic industry is the target field of application of spmilk bioplastic singleuse plastics often also referred to as disposable plastics are commonly used for plastic packaging and include items intended to be used only once the recent eu directive 2019904 the sup directive imposes from july 2021 eu wide market restriction measures bans for various singleuse products such as plastic cutlery plates stirrers and straws oxodegradable plastics and expanded polystyrene food and drink containers splastica business idea is to bring to the market spmilk bioplastic in the form of granules to be used by plastic processing companies with injection moulding and compression moulding machines or to produce films for industrial packaging applications project objectives within the women techeu program are the optimization of the bioplastic formulation to assess its machinability with industrial machines the material certifications bioplastic material compostability material in contact with food the study and design the wastewater treatment system inherent to the spmilk production process and the layout of a industrial scale plant
flight centric atc project

the flight centric atc project fca addresses industrial research validation for master plan phase c connected and automated atm horizonsesar2022desir01wa61 the main objective of fca is to finally develop v3 maturity level the flight centric atc concept for an ecacwide implementation in medium density traffic areas considering the existing national boundaries furthermore the project includes the development of ecacwide deployment scenarios which are consistent with the limitations of the vhf spectrum for voice communications ecacwide benefits of the concept in each of the deployment scenarios will be analyzed as well based on the exiting sesar2020 pj10w273 fca costbenefit analysis two different exercises and workshops will be conducted during the project to address the remaining gaps and to take the final step from a v3 ongoing solution to a v3 completed solution therefore an analysis will be conducted to validate the key performance indicators cost efficiency cef2 capacity cap predictability prd and fuel efficiency feff as well as human performance and safety in addition final validations will take place to validate eg the change from a sectorised airspace to flight centric atc and vice versa to assess the possibility of a fallback scenario to evaluate an appropriate allocation strategy and an acceptable approach for the opening and closing of cwps the final results will be dissiminated across the relevant stakeholders and the s3ju via scientific papers open days and a project website specificly designated to the industrial research flight centric atc project
mediterranean researchers night 2022 and 2023 editions

more than 500 million people on three continents are united by the worlds largest sea the mediterranean our strategic geographic location and the shared history gives us a common character and common challenges mediterranean researchers night mednight objective is to generate a mediterranean unity providing awareness about common problems fostering scientific careers reinforcing researchers commitment and progress and putting science and scientists at the cornerstone of our future and a relevant matter mednight shows the attractiveness and importance of the researchers work and professions to the general public and specially for girls and boys carrying out a series of activities framed under the common umbrella of what we have come to call mediterranean science placing particular emphasis on youngsters and female researchers and showing the potential of rd as a source of progress and wellbeing mediterranean science relates to research developed in the our territories but also the countless collaborations with other eu researchers mediterranean science is focused on mediterranean relevant topics according to our culture way of life or current challenges sea and pollution climate and clean energies diet and nutrition life and health many online and facetoface diverse activities are organised by mednight consortium in valencia san juan orihuela torrevieja messina lesvos nicosia istanbul main cities and also lliria santa pola limnos rhodes syros eyupsultan kadikov or el cairo among others satellite cities
era chair program to advance inflammation research at imbbforth

the institute of molecular biology and biotechnology imbb at forth stands as a beacon of scientific excellence in greece despite commendable achievements imbb faces significant challenges especially in the highly competitive field of biomedical sciences existing disparities between regional and european research approaches pose a hurdle that requires strategic alignment with broader european research initiatives to address this imbb aims to foster crossborder collaborations harmonize methodologies and ensure its continuous presence at the forefront of scientific innovation insufficient training programs and a growing shortage of skilled personnel present additional major obstacles for imbb persistent budget constraints hinder the institutes ability to maintain its research momentum and achieve innovative excellence imbb recognizes the importance of articulating and showcasing the realworld social and economic benefits of its scientific endeavours to bolster its reputation and garner sustained support in response to these challenges imbb introduces inflacare an ambitious program designed to recruit and fully assimilate the era chair holder and the inflacare team the programs objectives include enhancing the research capacity of imbb strengthening human capital improving capabilities in competitive research funding reversing brain drain boosting the institutes innovation capacity enhancing management and administrative competences maximizing benefits from eu and national investments raising imbbs reputation and promoting communication of ri results collectively the inflacare program aims to empower the institute to leverage cuttingedge technologies attract toptier researchers and cultivate collaborations that directly advance its research and innovation activities the tangible improvements in healthcare outcomes will underscore imbbs commitment to scientific excellence and its societal impact
condensates at membrane scaffolds integrated systems as synthetic cell compartments

comeincell will establish a novel integrated synthetic cell platform to provide cost and resourceefficient environmentally friendly widely applicable and quantitative model systems to elucidate key cellular mechanisms of health and disease based on the integration of condensate and membrane models understanding membranecondensate interactions is vital for deciphering their functional roles in cellular processes our consortium employs synthetic vesicles as model systems to explore these interactions these tailormade mimics of cellular compartments offer a platform for studying membrane dynamics and the impact of compartmentalization on the activity of reaction networks and the assembly of complex machinery we will design synthetic cells as lifescience prototyping tools to decipher the role of membraneassociated condensates in essential cellular processes linked to membrane transport membrane transformation metabolic networks and repair the network will confront global challenges providing solutions in drug development therapeutics greenrelated issues and synthetic biology our goal is to equip junior scientists with crossdisciplinary expertise for developing integrated synthetic cellular testbeds encompassing condensates and membranes revolutionizing prototyping systems we will train the next generation of biophysicists biochemists and bioengineers in rigorous quantitative and mechanistic thinking while establishing strong ties to young and emerging european smes in the health sector for efficient dissemination towards new therapies
sustainable glass industry with fuelflexible technology

europe is the world leader in glass making a highly energyintensive industry that emits high amounts of co2 the past century has seen improvements in the production process but they are now approaching their limits the objective of gifft is to develop a sustainable hybrid and biofuel flexible heat production technology and process that can be integrated into industrial glass manufacturing through efficient use of plasmaassisted combustion and gasification systems an integrated heat production technology and process for glass manufacturing will be developed utilising biomasswaste and excess or cheap renewable electricity for syngas production what will contribute to europes progress and leadership for bioenergy integration into industrial settings gifft will then develop and validate in an industrially relevant environment a fuel flexible entrained flow gasifier efg with a novel egasification function and a new plasmaassisted fuel flexible gas burner for hybrid operation in glass furnaces this will help diversify feedstock and improve the technological performance as well as cost reduction of bioenergy ensuring a better circularity and increased use of renewables the technoeconomic feasibility and environmental impact of the technology will also be assessed to confirm that gifft contributes to an increased sustainability of biomass combustion and gasification and bioenergy value chains while reducing emissions