Dragon09/odtu_chatbot huggingface dataset:
miniaturized devices for singleatom quantum technologies

we propose to realize a new and fully integrated approach for the manipulation of single neutral atoms which has the potential to transform the complex roomsized multimillioneuro experiments currently used to manipulate these atoms in academic laboratories into userfriendly economical and robust commercial devices the size of a shoebox as a proofofprinciple application we propose to realize an integrated single photon source based on a single trapped atom which has immediate commercial potential in quantum communication and computing
nextgeneration drug discovery platform for targeting cancer stem cell pathways

colorectal cancer crc is one of the most frequent cancers with a high burden on society in europe alone more than 340000 people are diagnosed with colorectal cancer each year while treatment options of crc have expanded over the last decades the survival rates of patients suffering from advancedstage cancers remain poor stemness of neoplastic cells has been proposed as a major factor in treatment resistance and high relapse rates however drugs targeting stem cell signaling pathways in cancer are still lacking today we propose developing and validating a new drug discovery platform based on patientderived organoids pdos and machine learningassisted phenotypic target validation and drug discovery using this platform we have previously shown that we can identify a broad spectrum of phenotypes beyond lethality including druginduced changes in stemness of pdos as part of the eic open transition project we will validate our nextgeneration platform for identifying therapeutics to target stem cell signaling pathways in crc based on results by us showing that an interaction of mek and wnt signaling shifts the balance between stemness and differentiated cells we will target wnt pathways as a demonstrator for the technology the achilleus project targets critical vulnerabilities in cancer and is based on technologies and approaches developed during previous erc advanced and erc proofofconcept grantfunded projects the projects ultimate aim is to spin out a newco as a phenotypic drug discovery platform for targeting cancer stem cell pathways
tuning the tracks resolving the interplay between microtubule lattice conformation and kinesin1 selectivity using cryoem

kinesin1 transports cellular cargos along microtubules as part of neuronal transport the localisation of kinesin1 in neurons is tightly controlled to ensure the coordinated delivery of specific cargoes to the regions where they are required one mechanism of control is through microtubule regulation but the details of this are not well understood it has recently been shown that microtubule lattice spacing influences kinesin1 localisation in u2os cells however the role lattice spacing plays in neuronal transport is unclear this project aims to investigate features of kinesin1 based neuronal transport on multiple scales first this project aims to use cryoelectron microscopy cryoem to elucidate how kinesin1 binds to specific microtubule subsets i will resolve the highresolution cryoem structure of a dimeric kinesin1 construct stablemark bound to microtubules with different lattice states this will explain its lattice specificity and help uncover the mechanics of kinesin1 walking secondly i will map microtubule lattice spacing in neurons using in situ cryoelectron tomography to establish the lattice diversity within this complex microtubule network thirdly i will use cryocorrelative light electron microscopy and stablemark to determine if lattice spacing influences kinesin1 localisation in neurons this project will answer key biological questions on cytoskeletal transport which will be applicable to other microtubulebased motors and microtubule associated proteins defects in kinesin1 based transport have been implicated in multiple neuropathies such as alzheimers disease therefore further understanding of how neuronal transport is controlled will help uncover the mechanism of these diseases
creating a centre of excellence on sustainable energy at ncsr demokritos

the proposed era chair aims to bring all the scattered energyrelated activities of ncsrd under the same umbrella through the creation of a unique centre of excellence coe with a primary focus on sustainable energy solutions towards netzero fossil fuels and climateneutrality by 2050 perfectly aligned with relevant eu policy priorities such as the european green deal the era chair will be established and hosted under this structure integrated in inrastes with synergies and links with a variety of internalexternal actors the coe operation will be primarily virtual meaning that not all of its personnel will work under the same physical lab or building but it will facilitate bridging the gaps across existing labs the era chair holder prof georgios tsatsaronis gt will establish this coe and coordinate the joint activities with the ncsrd labs and greatly expand the research topics due to his diverse skills and longstanding experience in the energy field gt will increase the research potential by 1 setting up and managing the coe 2 supervising and training its team members and 3 proceeding to institutional reforms inspired by his innovation culture via a range of serviceoriented activities gt will not only bring research excellence in the coe but also create synergies with a large range of stakeholders eg research institutions industry and increase entrepreneurship by enhancing knowledge transfer and better use of results aiming to upgrade the relevant services of the innovation office that are available to all ncsrd researchers the vision of the coe is to become one of the top groups for sustainable energy research in the eu and deepen the era and replicate its lighthouse example in other greek research actors to improve the local research ecosystem
measuring what matters improving usability and accessibility of policy frameworks and indicators for multidimensional wellbeing through collaboration

achieving the united nations sustainable development goals and the european unions policies on environmental and social sustainability requires a comprehensive measure of human progress that does not focus solely on gdp however the evidence on alternative approaches is fragmented and the lack of consensus on competing indicators and policy frameworks is a machieving the united nations sustainable development goals and the european unions policies on environmental and social sustainability requires a comprehensive measure of human progress that does not focus solely on gdp however the evidence on alternative approaches is fragmented and the lack of consensus on competing indicators and policy frameworks is a major obstacle to setting policy goals that promote multidimensional wellbeing and to monitoring and measuring progress merge addresses these challenges by providing a forum for dialogue cocreation and knowledge exchange and by linking cuttingedge research and policy practice a consortium of leading researchers and key communities in the field merge brings together three recently launched higher education research consortia spes tobe wise horizons and an erc grant real to scale up results merge provides a framework for creating and strengthening a multidisciplinary community of researchers a technical and knowledge network a policy network and a network of civil society actors through these networks merge aims to build a broad consensus on easytouse and acceptable indicators and frameworks for measuring multidimensional wellbeing within planetary boundaries in the eu and member states as well as in global organisations and civil society merge participants will benefit from collaborative and training events analyses indicators datasets and policy briefings through knowledge exchange stakeholders and researchers can adopt and develop a systematic and coherent understanding of the sustainable economy paradigm in their own work
preparing multiactor projects in a cocreative way

the societal challenges addressed by european union eu strategies such as the green deal and farmtoform require innovative solutions in agriculture forestry and rural areas the multiactorapproach maa is a promising instrument to speed up innovation however the h2020 ria liaison 20182022 has identified some deficits and inconsistencies in the interpretation of the maa by both current and potential ma consortia and member states ms authorities premiere will therefore foster the development of sound coherent and wellprepared ma projects in two ways firstly it will contribute to the building of project consortia that make best use of the complementary knowledge of their members during proposal writing project activities and beyond in particular by improving the connection between horizon europe he ma projects and operational groups og secondly through insights and tools it will support the implementation of innovative governance and sound decision making in policy and administration for the green transition by using the results from liaison and capturing grass roots ideas from project participants policy makers and executive agencies through stakeholder dialogue across all 27 eu ms including with the scar akis swg national contact points and other relevant he projects premiere will develop tools as well as training and networking events for capacity development these will include a serious game an online academy and a mooc the project will test out the effect of providing seed funding to at least eight ma organisations mainly ogs and prepare a handbook of good practices this userfocused workplan with its open science outputs will lead to more effective eu and national akis it will be implemented by a very experienced competent and genuinely ma consortium of policy makers executive agencies advisors for coinnovation partnerships akis actors andor and current and potential ma project partners
green surveillance imagining a sustainable internet of things

the emerging internet of things iot constitutes a communication system that enables comprehensive and continuous monitoring of the effects of human activity on earths ecosystems thus potentially facilitating the green transition to sustainable forms of social life but the scope and the scale of the necessary monitoring simultaneously entails surveillance not only of natural and built environments but of persons and their actions as well extending far beyond the online tracking of citizens and consumers which over the past decade has generated widespread public debate and motivated substantial legislation regulating digital infrastructures in the european union and beyondthe greenwatch project anticipates and assesses the ethical dilemmas that follow from green surveillance what kinds and which degrees of surveillance will the present human cohort be prepared to accept in the coming decades to ensure the livelihood of the species centuries and millennia into the future comparing the three world regions driving the development of iot europe the united states and china the study maps the empirical scenarios being projected for iot as part of the green transition theorizes the process of green surveillance as information feedback to national and international systems of governance as well as to individual citizens consumers and corporations and evaluates both the scenarios and the practice of surveillance against the background of classic philosophical traditions of local and global social justice complemented by recent conceptions of climate justice and environmental justice through iot earth is sending a message that the human species is obliged to respond to across ideological and civilizational divides for survival and at best individual and collective human flourishing eudaimonia
harnessing the dna damage response to improve plant tolerance to heat stress

in the context of climate change europe is facing new challenges that are threatening food security there is thus an urgent need for the development of innovative strategies to improve plant tolerance to stress notably recent years have already shown an unusual frequency of heat waves during the summer a stress condition particularly threatening for yield as it cannot be mitigated in the field like many other kinds of stress heat stress has a detrimental effect on growth due to reduction of the cell division activity in meristems there is accumulating evidence that this growth reduction depends at least partly on the activation of the plant dna damage response ddr the heatddr proposal aims at building on the acquired knowledge to decipher the links between the ddr and plant heat stress responses and to finetune these cellular responses in order to allow plant survival without impairing growth by bringing together groups with complementary expertise and private companies interested in this topic heatddr will combine multiscale approaches including biochemistry molecular biology cell biology genetics computational biology and plant phenotyping to tackle this question and to train a new generation of scientists specializing in this emerging field trainees will work on both arabidopsis and crops and will thus be aware of different plant models and on specific challenges associated with breeding through the heatddr programme esrs will receive handson training on advanced laboratory techniques and develop transferable skills thereby ensuring their successful integration on the job market either in the academic or in the nonacademic sector and setting the ground for the construction of european network of collaboration in this field
polar nightmidnight sun a history of sleep and time in the arctic 18001900

sleep is universal to the human experience a core element of our daily circadian rhythms sleep is a biological and a cultural phenomenon when we sleep how we feel about sleep and what we deem as normal varies with place and time the new science of chronobiology is demonstrating that the daily rhythms of sleep and wake eat and fast have far reaching consequences for our physical and mental health understanding this embodied time can provide a new perspective on the everyday experience of people in the past and open up larger questions about time and society this interdisciplinary project takes its start in the history of time and sleep and proposes to use an analysis of embodied rhythms to provide new perspectives on the history of arctic exploration european visitors to the arctic in the nineteenth century experienced it as a timeless space where the seasonal fluctuations in light quite literally turned day to night the polar night and the midnight sun challenged the crews emotionally and physically as disordered sleeping and irregular eating threatened physical and mental health at the same time the unpredictable magnetism of the north pole frustrated attempts to overcome the arctic timescape with the tools of european science pnms is innovative in its subject area and its methodology this project combines the tools of historical research with the insights of henri lefebvres rhythmanalysis to attend to bodily rhythms in the past in new and exciting ways following lefebvres influential methodological lens i propose to combine work on nineteenth century european sources with a contemporary rhythmanalysis travelling to svalbard in the arctic circle to observe the changing rhythms of residents in the bright summer and dark winter this action brings together the insights of the history of science environmental humanities temporality studies and feminist studies of emotion to gain new perspective on the arctic landscape and its rhythms
time to pay up reparations and global development challenges

reparations have become a popular demand in global development contexts disenfranchised groups from around the world and countries from the global south increasingly call for reparations they ask for apologies for past harm symbolic and institutional measures that recognize and prevent such harm and most controversially for monetary payments reparations are meant to respond to environmental pollution mitigate the worst effects of climate change compensate for infectious disease outbreaks and terrorist attacks and bring some degree of justice for indigenous peoples and other minoritiesrepair studies these new calls for reparations that address different global development challenges it compares reparations for infectious disease outbreaks climate change minority rights violations and toxic environments the projects research objectives are 1 compare how reparations payments are established implemented and received as part of addressing these global development challenges 2 learn what these payments teach us about reparations in development from an economic moral and political perspective 3 identify what kind of wealth transfer reparations constitute and what this tells us about the reparative aspects of economic life more generallyrepair is innovative in that it is the first comparative socialscience study of reparations in the field of development it not only analyses a new and important set of reparations cases but drastically broadens the comparative frame of their study moreover repair is the first research project to use novel theory and methods from economic anthropology to study reparations this promises relevant new insights into their sociocultural nature and effects lastly by investigating reparations as a form of wealth transfer and focusing on the reparative aspects of economic activity repair hopes to push the boundaries of our understanding of economic life in general
integrated decision support tool for reliable and affordable application of manage aquifer recharge with alternative water resources in river basin and drought management plans

marclaimed will be a breakthrough addressing in an efficient sustainable and trustworthy way the water scarcity and water stress mitigation marclaimed will support decision makers to integrate managed aquifer recharge mar with alternative water resources awr in river basin and drought management plans supporting the adaptation and resilience of structural supply systems in the context of climate change the main outcome will be the marclaimed integrated decision support tool idst that will provide solutions to tackle existing and emerging threats and support decision making and adaptation policies marclaimed idst will ensure i high level operational performance through 3 aibased tools to i monitor and control awr quality ii forecast the water resources availability and iii provide health environmental and performance risk indicators ii economic sustainability under uncertainty providing i a municipal scale water scarcity indicator ii water security economic value of mar with awr and iii a cost recoverybased system and iii social acceptance strengthen the engagement of national and eu policy makers in collaboration with a community of practice and the definition of eu marlines as rules and guidelines to promote policy recommendations and boost regulatory frameworkmarclaimed results will be implemented and validated in 3 demo sites in southern pt es and western europe nl chosen by their wide range of settings in terms of climatic conditions alternative water sources mar scheme or mar potential as well as political and sociocultural context in addition to cover a wide spectrum of economic sectors and activities an industrial feasibility study in the mining sector will be carried out in central pl and eastern europe ris countries
ancient spaces of healing integrated perspectives for the study of urukean medicine 1st millennium bce

the overarching goal of the project ashipum is to understand how ancient mesopotamian healers acted within their spatial geographical and social contexts to do this i will conduct a practiceoriented study still lacking in assyriological scholarship of the archives of the exorcistshealers from latebabylonian uruk end 5th centurybeginning 2nd century bce integrating textual and archaeological data this case study has not been comprehensively analysed from a medicohistorical viewpoint by focusing on its promising features i will be able to overcome three problems related to the study of mesopotamian medicine ashipums objectives are 1 to determine what the exorcistshealers of latebabylonian uruk knew on the basis of their archives 2 to integrate textual information with archaeological and material data relevant for a medicohistorical study 3 to reconstruct the daily practices and the knowhow implied by healingrelated activities in uruk as designed the project will be best implemented at paris 1 university panthonsorbonne under the supervision of philippe clancier in the light of his expertise in the archives of the exorcistshealers and their historical material contextualisation i will benefit from my integration into his team arscanharoc specialized in material culture and the trainings offered by my host institution in archaeology anthropology french language digital skills project management and career development in turn i will share my experience on mesopotamian medicine and give impulse to this subject at arscan by networking with specialists across the region of paris and beyond the action includes dissemination activities through presentations journal articles a conference with related proceedings and online content for arscans projects communication will be ensured by online presence participation at outreach events in the parisian region a citizen science program and a poster exhibition
migratory 1nfluoroalkylcarboxylation of nonactivated alkenes via dual photoredox nickel catalysis

catalytic chainwalking reactions have recently emerged as a powerful tool for efficiently introducing functionalities at remote sp3 ch sites within alkyl side chains nevertheless substantial challenges remain when forging multiple cc bonds while maintaining a predictable siteselectivity profile in chainwalking scenarios particularly by controlling both regioselectivity and enantioselectivity this project will explore the ability to introduce both fluorinated fragments and co2 at an unsaturated hydrocarbon via dual photoredoxnickel catalysis with a predictable selectivity pattern such a transformation constitutes an unrecognized opportunity in chainwalking scenarios for introducing at will fluorinated fragments and carboxylic acid functions in a dual yet modular siteselective manner aimed at exploring the full potential of such an approach for accessing addedvalue fluoroalkyl carboxylic acids a new class of c2symmetric ligands will be rationally designed and developed the impact that this technique might have in industrial endeavors will be assessed in collaboration with industrial partners of the host group by its application in latestage modification of advanced intermediates radiolabeling and the synthesis of mri probes