Dragon09/odtu_chatbot huggingface dataset:
developing roles for phosphates outside of biology a systems chemistry approach towards abiotic phosphate fuels

phosphates and phosphate esters underpin biological information transfer signal transduction and contribute to the energetics of life biochemical fuels that include phosphates atp gtp drive selective processes by incorporating chemical information a vs g in their fuel structure despite the multifaceted role of phosphates in biology their use in supramolecular systems chemistry remains largely underexplored phosphotosuprachem develops roles for phosphates outside of biology and capitalizes on the idea of providing chemical information within abiotic phosphate fuels to control selectivity and reactivity in the context of fueldriven structure formation the information is provided by chemical functionalization of energyrich phosphate fuels whereby the information encode structural assembly of fuels prior to their consumption or transfer large chemical groups onto selfassembling species during energy transfer specific aims are i understand the chemical design space for phosphate fuel selfassembly and how such structures control selectivity and reactivity when transferring the energy for the formation of transient assemblies ii construct fuels capable of transferring structural information enabling folding and chimeric dissipative selfassemblyiii promote wastedriven fuel formation substrate release and peptide bond formationv involve fuels in automated synthesis for microfluidics materials discoveryphosphotosuprachem pioneers an unexplored area of science at the roots of dissipative systems and phosphatedriven systems chemistry this strategy profoundly contrasts the present nonequilibrium selfassembly research featuring fuelling with molecules that lack structural and recognition elements in the long term fabricating biocompatible dissipative systems and developing automated platforms that guide fuels to specific functions will be a decisive step toward creating dynamic assemblies in vivo and programming active soft matter
timedelay photoionization of coreorbitals in the molecular frame

the recent development of broadband coherent extreme ultraviolet sources makes it possible to measure dynamics with attosecond resolution 1 attosecond 1018 s this time scale is associated with the electron dynamics and more particularly to the electronic correlation in various systems from atoms and molecules to solids generating and controlling processes on this time scale then gives the opportunity to develop new promising applications in chemistry and biology that can have high impact in societytdpicomf aims at studying electronic correlation through the measurement of the photoemission delay of coreorbital electrons in a lasercontrolled molecular system for this purpose tdpicomf brings together advanced technologies from the attosecond interferometry field and laserinduced alignment field in order to resolve both spatially and temporally the photoemission processin particular the research project proposes to study as a prototype the photoemission from the 4d coreorbitals of the iodine atom in iodine monochloride icl molecules in gas phase the measurements will be realized during different laser controlled configurations of the molecular system eg during its alignment orientation and dissociation the expected impact is to gain a global picture of the influence of the molecular cationic potential during a chemical reaction and to evidence the role of electronic correlation through the measurement of 3dscattering phase maps in the molecular frametdpicomf will utilize existing and forge new international collaborations between experiment theory and academia in order to tackle this complex problematic the results of our work will be made globally available and presented to the general public the post doctoral fellow will bring to the host his expertise on laser control of molecular systems and will be trained to the attosecond science and technologies enlarging his scientific experience and employability
european training network for developing smart neuromonitoring solutions to support precision medicine in acute central nervous injury

in traumatic brainspinal cord injury and stroke major causes of death and disability progress has come from monitored intensive care and swift action upon detection of secondary insults although it is possible to monitor intracranial pressure the brain spinal cord still behave as a black box current measurable signals only roughly represent ongoing pathophysiological processes and dynamic insults eg impaired autoregulation and neurovascular unit dysfunction cannot be reliably monitored as a result no therapeutic action has been shown to be beneficial in randomized patient trials the project goal is to prepare novel dynamic insult monitoring technologies and to develop improved decision support by integrating disease models and insulttreatment ontologies into smart multimodality monitor software a parallel goal is to unite high level expertise in clinical biomedical statistical and engineering sciences into one network to boost the next generation of researchers to substantially advance the field of neuromonitoring the network includes 3 relevant animal models and access to large multicenter patient databases with injury treatment outcome data eg centertbi direct autoregulation visualization in the cranial window piglet model will be elaborated to improve circulation models and relations with measurable high resolution signals to develop a realtime autoregulation monitor these metrics will be associated with spreading depolarizations vasospasm ischemia and brain function in the rodent stroke models the models and monitor technology are highly transferrable to patient care patient data will be used to build multidimensional statistical disease models insult and treatment ontologies will be developed in parallel with insult prediction and insult burden visualization concepts smart monitor platforms that aid precision medicine in acute central nervous system injury close to trials and future innovation leaders are expected results
pathogens of algae for biocontrol and biosecurity

algae play an important role in water ecosystems and our future increasingly depends on the presence of both desirable and undesirable algae desirable algae are for example seaweeds that we consume use for biofuels pharmaceuticals and cosmetics whereas undesirable algae can form harmful algal blooms habs that can alter the quality of water with dramatic consequences for wild and farmed fish and shellfish as well as our supply of drinking water micro and macroalgae are vulnerable to many diseases the presence of pathogens and their potential spread to nonnative areas can significantly hinder seaweed production likewise microscopic algae ie cyanobacteria diatoms and dinoflagellates that can form habs are also vulnerable to many pathogens there are a wide range of microorganisms including fungal oomycete protist bacterial and viral agents that can all reduce fitness or kill algae therefore the central research aim that links all 10 training projects in phabb is to exploit the infection strategies of algal pathogens to either fight diseases that they cause in seaweeds or to harness these infection tactics to combat harmful algal blooms to achieve this goal phabb brings together an exceptional combination of researchers in europe from both academia and smes that have unique expertise to train and mentor 10 early career researchers in understanding biological and evolutionary processes linked to microbial community dynamics virulence and host specificity of a range of pathogens of both desirable algae as well as undesirable algae the overall aim is to develop new disease management strategies in seaweeds and biocontrol measures of habs with the help of natural pathogens the esrs in phabb will gain broad interdisciplinary skills plus a translational mindset through our integrated and intersectoral training programme and will secure continued vital research on biocontrol of habs and biosecurity of seaweeds in europe
uncovering the creative process from inception to reception of translated content using machine translation

the new machine translation paradigm neural machine translation has drastically changed societys perception of technology and the act of translation it has also motivated a series of claims by research labs and the media implying that machines will soon decode the transfer of one language to another thus driving professional translators out of their jobs creative content producers such as streaming platforms or publishing houses are now exploring testing or using neural machine translation yet little is known of the constraints this technology poses to translators creative process and how such constraints impact the users the need to understand this has become essential to sustain translation richness translators job satisfaction authors and directors reputations and the user experienceincrec aims to uncover the creative stages of professional translators to understand how technology can be best applied to the translation of literary and audiovisual texts and to analyse the impact of these processes on readers and viewers the research project is articulated in four work packages that cover two broad areas inception and reception of literary and audiovisual translation to better understand this complex process increc triangulates data from eyetracking retrospective thinkaloud interviews translated material and questionnaires from professional translators and usersthus increc develops a new theoretical framework that encompasses a creative stages in translation b classification and mapping of translation problems which require a higher level of creativity and cognition as well as a classification of the solutions to these problems c understanding how machine translation is most effectively used during this creative process and d understanding user attention to creativity in translated literary texts and films this is achieved using a new combination of methods from different disciplines
mribased id of the vasculature across the heartbrain axis

microvascular impairment is a hallmark of many of todays most burdening diseases including forms of ischemic heart disease stroke and dementia it is also the most promising candidate to explain the link between cardiovascular and brain disease socalled heartbrain axis however only histology provides comprehensive assessment of the microvasculature and is rarely available in vivo as it requires invasive biopsy the lack of early noninvasive markers limits our pathophysiological understanding and crucially affects treatment success as preventive intervention is the only successful clinical management strategy availablewith a major leap in magnetic resonance imaging mri physics i will address this need and develop vascularid a fully noninvasive toolset for the quantitative assessment of cardiac and cerebral microvasculature this noninvasive biopsy exploits microscopic magnetic fields around the vessels to obtain structural information about the microvasculature it is contrastfree and resilient against field inhomogeneities and can for the first time be used in both the heart and the brain combined with a new generation of noncontrast perfusion mri vascularid will provide comprehensive functional and structural informationmy approach will first be validated in a microprinted 3d model of the vasculature in vivo feasibility will be demonstrated in an animal model proofofprinciple studies with vascularid in a cohort of patients suffering from heart disease and a cohort of patients with cerebral small vessel disease will demonstrate the clinical feasibilityi will develop validate and disseminate vascularid for research and clinical use to enable groundbreaking insights into the smallest blood vessels these insights are perfectly poised to provide the missing key to the vascular underpinnings of diseases that form the major burden to our health care system in the years to come
spikezip a retinomorphic encoding method for lowlatency and lossless data compression and telemetry of largescale invivo neural recordings

invivo neural recording and transmission of a vast number of neurons is essential in comprehending the brain and nervous system however the core challenge in the field of highchannelcount invivo neural recording is the limitation in transferring data posed by the bandwidth and energy consumption which currently lacks a viable telemetry solution to effectively address this challenge this poc project introduces a novel retinomorphic encoding method spikezip which offers several advantages over existing approaches for processing neural data such as low information loss minimal latency and reduced hardware overhead the technical advances demonstrated in this project will have significant impacts on various applications areas such as neuroscience research with freemoving small animals lowlatency closedloop neuromodulation implantable braincomputer interfaces and cognitive prosthetics the proposed method has the potential to revolutionize the way we record and process neural data enabling us to better understand the brains cognitive functions and develop new therapies for various neurological disorders this poc project will develop a robust demonstration system and rigorously validate it in small animal studies with settings that can be effectively applied and translated across a diverse range of neuroscience and neurotherapeutic applications spikezip will develop a gotomarket strategy that highlights the technologys unique features and benefits with a focus on ip and licensing opportunities and engaging with industry partners to identify promising commercialization opportunities
costeffective production of lignin platform chemicals extending the biobased chemicals portfolio

europes ambitious sustainability and climate goals are heavily relying on the transition from fossilbased to biobased chemical building blocks lignin as abundant natural resource has substantial potential to serve as starting material for the production of functionalized aromatic compounds only 12 of the lignin annual production is used in chemical conversion critical challenge to overcome is the heterogeneous and complex nature hampering the full exploitation of isolated lignins to address this challenge countless will demonstrate the first catalytic hydrogenolysis process operated in continuous mode at industrially relevant scale for the costeffective and sustainable production of ligninbased platform chemicals countless will demonstrate the applicability and costeffectiveness of ligninbased platform chemicals in a variety of enduse cases from bulk to specialty applications this project is formed by key partners covering the whole value chain including feedstock suppliers technology development experts wellrecognized industry players in the respective application fields experts in dissemination communication and exploitation and experts in integrated sustainability environmental and technoeconomic assessments revenue streams will result from licensing agreements and an increase in turnover and margin for countless suppliers and application partners we anticipate a positive npv and irr in 15 years of operation countless contributes directly to the cbeju sira and kpis through the increased use of sustainably sourced biomass reduction of ghg emissions through improvements in the pilot infrastructure 50 reduction in ghg emissions and 85 using fully renewable supply and the development of biobased highvalue products substituting current fossilbased compounds
adaptive multidrug infusion control system for general anesthesia in major surgery

a major challenge in anesthesia is to adapt the drug infusion rates from observed patient response to surgical stimuli the patient models are based on nominal population characteristic response and lack specific surgical effects in major surgery eg cardiac transplant obese patients modelling uncertainty stems from significant blood losses anomalous drug diffusion drug effect synergyantagonism anesthetichemodynamic interactions etc this complex optimisation problem requires superhuman abilities of the anesthesiologist computer controlled anesthesia holds the answer to be the game changer for best surgery outcomes although few clinical studies report that computer based anesthesia for one or two drugs outperforms manual management in reality clinical practice mitigates a multidrug optimization problem while accommodating large patient model uncertainty the anesthesiologist makes decisions based on future surgeon actions and expected patient response this is a predictive control strategy a mature methodology in systems and control engineering with potential to faster recovery times and lower risk of complications the goal of this proposal is to advance the scope and clinical use of computer based constrained optimization of multidrug infusion rates for anesthesia with strong effects on hemodynamics i plan to identify multivariable models and minimize the large uncertainties in patient response with adaptation mechanisms from nominal to individual patient models we design multivariable optimal predictive control methodologies to manage strongly coupled dynamics to maximize performance of the closed loop we model the surgical stimulus as a known disturbance signal and additional bolus infusions from anesthesiologist as known inputs i am convinced that integration of human expertise with computer optimization is a successful solution for breakthrough into clinical practice
aerospace districts acceleration of the strategic transfer of regional advancements

adastra aerospace districts acceleration of the strategic transfer of regional advancements is a project about the positive interconnection among innovation ecosystems with a focus on aerospace sectorsthe proposal aims at the development of a connected competitive interregional innovation ecosystem between 5 eu regions toulouse south holland madrid apulia emiliaromagna with a shared interest in fostering aerospace sectors enhancing the crosscontamination to and from other innovative sectors eg automotive biomedical agrifood big data different innovation readiness levels aerospace districts with different levels of maturity and consolidation diversity generates wealth the collaboration of these markedly diverse regions furthermore represented by partners from different spheres of the quadruplehelix will be a growth opportunity the establishment of a solid and longlasting collaborative eu network able to exploit complementary skills experiences territorial and industrial vocations will contribute to create a critical mass in eu strategic sectors such as innovation and aerospace where global competition leads to a confrontation with actors of increasing size and requires innovative models and approachesthis ambitious goal will be achieved through an iterative process starting from the collection analysis and systematization of the experiences competencies technologies networks of the partner regions with reference to their aerospace districts analyzing the future evolutions of the ecosystems in response to technological economic political and social megatrends correcting or validating hypotheses and evolution models with the support of stakeholder groups defining an action plan for the development of each of the regional aerospace ecosystems valuing experiences and good practices stemming from other regions and strengthening spinin and spinout processes to and from other industrial sector and territories
molecular dissection of viral genomes for future antiviral treatments

viruses are obligate pathogens with massive impact on global health nearly all currently marketed antiviral drugs target viral enzymes we hypothesize that hitherto unrecognized virusencoded transmembrane proteins may prove valuable as pharmaceutical targetsthrough a systematic dissection of viral genomes wp1 we will identify potential transmembrane segments in a defined workflow we will predict their function in silico wp2 as being either a internalizing transmembrane proteins or b ion channels segments showing promising transmembrane andor internalization motifs will be expressed functionally characterized and evaluated in proofofmodality assays wp3 the newly identified internalizing proteins may transfer a molecular trojan horse a toxin payload into infected cells which will be tested with a generic fusiontoxin protein mode a while the potential viral ion channels viroporins will be tested for their ability to mediate a current via formation of ion pores mode b in wp4 the internalizing transmembrane proteins passing the wp13 attrition will be utilized for initial drug discovery and fusiontoxin protein design through cointernalization with the viral transmembrane protein the toxins may prevent longterm pathologies by eradicating the virus the novel viroporins will be screened for inhibition using ion channel drugs regulatory approved for other purposes this ensures fast access to the market through drug repurposing allowing for prevention and treatment of acute virus pathologythis project on new ground entails high risk yet also creates opportunities of enormous gain considering the huge unmet medical needs for effective and specific antiviral therapeutics however the biggest gain is the potential for groundbreaking discoveries regarding virally encoded transmembrane proteins thereby bridging basic virology and molecular pharmacology with structural biology and early drug discovery in a highly innovative manner
threedimensional imaging of selective particle storage in nanocapillaries

precise manipulation of colloidal particles is essential to foster nanotechnology applications in chemistry materials biology and devices fundamental insights into their dispersion assembly and reactivity enable precise engineering of advanced materials and the development of innovative nanoscale devices thus revolutionizing fields ranging from catalysis to electronics for instance colloidal particles with antagonistic electrophoresis dep properties can be selectively inserted into a nanocapillary when considering nanoparticles as carriers of data in a medium like water arranging them in a specific sequence in the nanocapillary enables data storage the feasibility of this particle storage relies on the ability to visualize and manipulate the nanoscale motions of the nanoparticles one of the most sensitive and accurate ways to track particle movement is by monitoring individual particle fluorescence in optical microscopes which is crucial for noninvasive imaging of particles in any colloidal environment spsnano aims to develop a threedimensional dynamical imaging method to track and understand the controlled motion of nanoparticles using dielectrophoresis this colloidal data storage is an alternative to current stateoftheart solidstate devices which have fundamental limits to the scaling potential hindering the way to costeffective memories spsnano lays the foundation of colloidal data storage technology which can enable lowcost highdensity memory by reducing the particle size and increasing the nanocapillary aspect ratios in the future