Dragon09/odtu_chatbot huggingface dataset:
utilization of h2o2 in transpiration cooling system for active heat protection and implementation of thermal decomposition for catalyst free h2o2kerosene bipropellant aerospike rocket engine

the rapid increase in the number of small satellites in recent years has dramatically boosted the probability of orbital collisions that inevitably create space debris to preserve the orbits sustainability a storablestable environmentallyfriendly highly efficient and compact propulsion system is required to be mounted on the satellites hydrogen peroxide h2o2 and aerospike engines are promising candidates if the major flaws are solved catalyst performance degradation due to stabilizer poisoning and extreme thermal loads at the spike structure in this proposal i want to test the novel concept of utilizing the thermal decomposition process of h2o2 by turning the aerospike engines cooling challenges into an advantage liquid h2o2 adsorbs heat from the structure convectively then vaporizesdecomposes to create gas layers to protect the structure from the direct contact of the combustion gas the thermal decomposition of h2o2 eliminates the use of catalysts overall the concept offers a unique approach to an efficient compact and durable propulsion system for small satellitesin the project liquid h2o2 will be injected into the h2o2kerosene stagedcombustion vitiatedair heater through the additive manufactured porous metallic wall fraunhofer iws testing in various conditions heat fluxtemperaturepressure will be measured directly key variables da and h cant be directly measured hence the mathematical model will be formulated to derive these variables under given conditions the model will be validated by comparing the monobipropellant flame front locations between the simulationsexperiments then i will generate a loworder modeling tool that can predict the cooling performance and combustion efficiency based on the data and the model the tool will be implemented to apply the new concept to existing tud etholox rockets the spike module will be fabricated integrated and tested for concept verification
alternative chemicals and materials integrating safety sustainability new production technologies and socioeconomic aspects

the alchemissts project will demonstrate the applicability of the safe by design ssbd framework aiming at developing and implementing safer and more sustainable alternatives to surfactants plasticizers and flame retardants that being present in daily life products pose a high risk for the human health and the environment thus considered substances of very high concern svhc to this end up to seven case studies accounting with the relevant actors in the value chain are proposed in the project and they will serve as proof of concept to test the ssbd framework against within its different 5 steps the general objective of the project will be achieved by addressing specific goals such as the development of the alternative substances itself the compilation of robust and reliable evidence for a proof of concept of the ssbd framework the development of a certification methodology promoting the implementation of the ssbd concept in the industrial network another key pillar of alchemissts project relies on the implementation of integrated approaches and tools to support safety sustainability and social assessment based on interoperable fair data and models in addition robust data on sustainability indicators and information for assessing the impact of the outcomes of the project towards a suite of zero pollution targets will be delivered for each case for all these relevant aspects alchemissts will be assisted by stakeholders to ensure social acceptance and economic of the foreseen innovative advance materials
support to the vicepresidents of the erc scientific council 20242025

this project provides the necessary support to the vicepresidents of the european research council scientific council erc scc to achieve key milestones and deliverables of the scc which are required under the horizon europe framework programmeunder the horizon europe programme the european research council provides a competitive funding mechanism for investigatordriven frontier research at the european level one of the key structural components of the erc is the scientific council consisting of 21 eminent researchers and their president representative of a large range of disciplines and institutional backgrounds the erc scc independently establishes and oversees the ercs scientific management and the implementation of the work programme including the peer review and the selection of peer reviewersthe project aims to support the erc vicepresidents who unlike the erc president act on an honorary basis in the efficient and timely achievement of the sccs objectives in 2024 and 2025 the diverse responsibilities of the three vicepresidents of the erc include the achievement of efficient and effective functioning of the scc its integrated operation together with the erc executive agency ercea and effective interfacing with the scientific community other funding agencies and the political institutions of the european union the project provides administrative and research support ranging from secretarial tasks to assistance in developing policy papers related to the work of the vicepresidents of the erc for a period of two yearsthe project objective is to provide local administrative operational and advisory support for the three erc vicepresidents the project contains a single work package which encompassed all the various tasks associated with this objective
leveraging african genomic sequencing platforms for public health impact

the objectives of our proposed work are well aligned with the goals for the collaboration between the global health edctp3 and the bill melinda gates foundation bmgf joint undertaking under topic ghedctp32022call10202 the participants listed in this proposal are key members of the africa pathogen genomics initiative africa pgi and the global health network tghn the participants will leverage these two existing platforms to provide access to expertise and resources in genomics from afpgi and clinical trials research and data science from tghn to edctp grantees in genomic epidemiology hereafter referred to as edctp grantees to be selected under topic ghedctp32022call10103 specifically the grant funds requested for this project will fund one fulltime project manager dedicated to supporting coordination activities between edctp grantees and the participants the project manager will be based at university of the western cape and will work closely with africa cdc while africa cdc is not a formal participant in this proposal not among the legal entities receiving direct funding they are core stakeholders and leaders in the project notably via collaboration with aslmjointly these platforms combined with the coordination activities described in this proposal will support as relevant edctp3 grantees to implement usecases in genomic epidemiology and advance the stated objectives above over the past four years we have seen genomic sequencing programs significantly advance and expand in africa helping demonstrate that the goals outlined within this project are measurable verifiable and realistically achievable
from endosymbiont to organelle mechanisms of cellular integration between paulinella and its chromatophores

the endosymbiotic integration of cyanobacteria within eukaryotes was one of the pivotal evolutionary transitions this transition however is difficult to study because modern plastids represent highly derived endstates and are not transitionary we know therefore very little about the mechanisms involved primary plastid endosymbiosis has occurred only twice once in the ancestor of archaeplastida and once independently in the amoeba paulinella each paulinella cell houses two chromatophores which are photosynthetic units that resemble plastids yet are more closely related to cyanobacteria genetic studies of paulinella and its cyanobacterialderived chromatophores revealed it is an intermediary in the evolution of a photosynthetic organelle studying paulinella therefore offers unique insight into the mechanistic processes of plastid integration despite our growing genetic knowledge little is known about the integration of the chromatophores in terms of their cellular physiology in this proposal i aim to address this by exploring this unique association at the metabolomic transcriptomic and proteomic levels first i plan to characterise the metabolites exchanged between the cell and chromatophores using an isotopelabelling metabolic experiment objective 1 second i will study the coordinated light response of the nucleus and chromatophore at the transcriptional metabolic and protein level objective 2 finally i will perform a longterm evolution experiment to expose paulinella chromatophora to high and fluctuating light regimes to test whether its light regulation can evolve in response to different light environments objective 3 the outcomes will provide insight into the molecular mechanisms that facilitate the integration of the chromatophores within paulinella this in turn will aid our understanding of the acquisition and integration of plastids and the evolutionary trajectory from endosymbiont to organelle
column with aceof induced vortices for hplc

in most highperformance analytical instruments which are used to carry out blood analysis for example the first step is separation in which the various components in a sample to be examined are divided into groups before being presented to a detector further improvement of the process is limited due to the slow spontaneous transport of the components in the traditionally exploited naturally occurring diffusion processin the context of erc starting grant evodis the flow group of prof wim de malsche of vub was able to generate a vortex mixing effect between channel walls of microdevices in order to accelerate the mass transport rate much more than what is possible by pure diffusion only therewith reducing dispersion this effect was achieved by applying an oscillating electric fieldin evolc these lateral vortices will be integrated in an hplc column to realize an improvement in chromatographic efficiency by a factor of 23 under relevant chromatographic conditions as part of the erc poc a demonstrator for such miniaturized hplc column will be built the new column promises faster and higherperformance separations in a miniaturized system which can be used in analytical labs but also for patients in a pointofcare setting one possible application is the analysis of haemoglobin levels for better diagnosis and monitoring of diabetes
multifrequency and machine learning methods to search for early super massive black holes

early super massive black holes smbh continuously push our understanding of the formation of galaxies and structures in the universe smbh accreting matter under the radiojet mode produces powerful relativistic jets and emit beamed nonthermal radiation from radio up to very high energy gammarays those jets pointing directly to earth create the socalled blazar phenomena where the source appears exceptionally bright due to relativistic magnification beaming effects we can spot blazars up to high redshifts but they are rare given the geometrical alignment constraints involved to date only a few distant blazars are known eg qj09066930 z557 and pso j030947271757 z61 and a direct search for new ones is impactful because each source at z 5 implies the existence of thousands of similar misaligned objects a systematic investigation at z 56 will provide a robust lower limit for the density of jetted smbh close and within the epoch of reionization eor this research proposal aims to apply machine learning ml techniques coupled with multifrequency data to search for high redshift blazars candidates we plan to select promising z7 candidates based on the damping wing pattern dwp the dwp manifests as the absorption of the observed wavelength 970nm 121nm restframe due to neutral gas in the intergalactic medium igm at z 7 and is very sensitive to the neutral fraction of the igm the dwp allows to probe well within the eor phase and provide a remarkable view into the early universe this proposal will leverage fresh survey releases as the catwise2020 in ir and erosat q42022 in xrays and benefit from the leading role of instituto de astrofsica ia within askap and moons projects which will provide deep radio data and support for optical observations this plan will apply ml to a complex multifrequency data frame in search of highredshift sources and contribute to establishing the fastemerging branch of astroinformatics
a new eu framework for an ecological ai

ecoai aims at creating a new regulatory framework for an ecological ai to align ai development with sustainability bridging gaps in scholarly efforts but also providing policy suggestions to eu institutions facilitating evidencebased decision making and ensuring that the proposed regulatory framework is a blueprint both for technology regulation more broadly and for noneu countries brazil will be a case study in this respect other countries legislation could also be influenced by signing cooperation agreement on the sustainable use of ai it is for this reason that ecoai aims also at drafting a proposal for an agreement between the eu and brazil to strengthen their cooperation in addressing the global challenge of climate change using ai to build this new framework and the proposal for an agreement on ai for the public good between the eu and brazil i will develop and test in intersectoral practical environments and in two different legal frameworks ie eu and brazil the innovative concept of ecological ai the possibility of using ai in an ecological way for the public good in accordance with the fundamental rights enshrined in the charter of fundamental rights of the eu to reach this objective ecoai has a strong interdisciplinary approach bridging law computer science and political sciences with some exposure to sociology taking into primary account the needs of the public and private sector and those of citizens who are the category mainly exposed to the negative effects of climate change to ensure the successful implementation of these project goals to gain new skills and competences and to identify solutions to two of the biggest challenges of our time the university of siena unisi and the university of san paolo usp are the most appropriate venues this research directly contribute to achieving horizon europe the european green deal the european data strategy the digital compass 2030 targets and the sdgs
mode locking for advanced sensing and imaging

the optical frequency comb is a spectrum of evenly spaced narrow laser lines optical frequency combs have revolutionized time and frequency metrology by linking microwave and optical frequencies however realizing their full potential in a broader range of applications such as 3d imaging environmental sensing lidar and highspeed optical communications is conditioned by the availability of inexpensive highly miniaturized devicesprogress in integrated optics towards chipscale frequency combs has made significant strides in recent years ugent has been at the forefront of this evolution it has developed unique technologies in heterogeneous integration enabling the longmissing functionality of optical gain on a chip this unlocks the full integration of combs in particular in the infrared but also in the nearinfrared range 8001100 nm the key to sensing in waterdominated media as encountered in biological samples eg in optical coherence tomography setting food industry and environmental sensingin molokai ugent will engage in a close collaboration with the group at mbi which is the pioneer of the applications of frequency combs applied to dualcomb interferometry and in particular the initiator of the extension of frequencycomb techniques to 3d imaging and to raman spectroscopy in this way in molokai we aim to leverage the latest breakthroughs in chipscale frequencycomb technology to transition these technologies in a reallife settingmolokai will work further on our initial dualcomb results to make a broadband onchip interferometer for that molokai will collaborate closely with ibsen photonics a spectrometer company to make highresolution spectrometers that can be used to read out bragg sensors in fibersnext the dualcomb technology will be ported to a gaasonsilicon nitride platform here dualcomb systems allow for the prospect of highresolution images
trasdej transatlantic alliances between sexual dissidents for environmental justice

the research trasdej transatlantic alliances betweenthe research trasdej transatlantic alliances between sexual dissidents for environmental justice focuses on explore analyze and create horizontal bridges between the multiple political spaces of struggle for environmental justice from the indigenous sexualdissidents in the south of mexico and dynamic spaces of queer struggles berlin and rural communities against coal mines in germany it addresses the question which socioenvironmental strategies can be observed among indigenous sexgender dissidents from southern mexico for the defense of their territories and european queer activists for environmental justice following this question and using a critical ethnography methodology trasdej focuses on concrete and local life experience from sexgender diverse actors for environmental justice across the atlantic ocean the research deploys a mixed methods approach narrative interviews autoethnography focus groups as well as knowledge exchange workshops kew with a combined format mixing facetoface and digital encounters the proposal makes use of postcolonial intersectional and nonbinary gender approaches to analyze and make visible the strategies from sexgender dissidents inside the socioenvironmental struggles in germany and southern mexico trasdej aims at providing facetoface and digital platforms for exchange experience of resistance vulnerabilities and social struggles between indigenous sexual dissidents in the south of mexico and queer european activists it will also create spaces for exchange of experiences and identify the differences similarities and potential bridges for the study of sexualities and international collaborations between subaltern groups for environmental justice
psilocybin therapy for psychological distress in palliative care patients

relieving serious healthrelated suffering for patients in palliative and endoflife care be it physical psychological social or spiritual is a global ethical responsibility however the profound psychoemotional and existential distress entailed by such suffering despite often being an enormous burden for both patients and their loved ones remains a field largely overlooked by health care providers and the scientific community those people may develop mood or anxiety disorder for which neither nonpharmacological nor pharmacological interventions exist in this context we believe it is now time to target these unmet needs in the palliative care population we want to initiate a paradigm shift at the boundaries between palliative care psychiatry psychology neuroscience and spiritual care our starting point is the preliminary results being reported for administration of psilocybin the main psychoactive compound of socalled psychedelic mushrooms in patients with depression the objective of our project is thus to examine the clinical effect of a cuttingedge individualised and patientcentred open and standardised psilocybin therapy addressing these unmet needs of patients in palliative care we will show high quality evidence via a multicentre randomised clinical trial of the value of our therapeutic model in patients and for the following four conditions copd atypical parkinsonian disorders als and multiple sclerosis their loved ones and care providers in a diverse sample of the european population in addition to better understand the mechanisms of therapeutic change of our model finally our project will establish a sustainable multidisciplinary ecosystem of key european stakeholders jointly contributing to the medical use of psychedelic research and innovation paving the way towards an ethical and costeffective deployment of such a new line of care for patients in european palliative care service providers
the plant hologenome is plant adaptative potential shaped by its microbionts

explaining why related species have very different abilities to spread adapt and survive is a central question in evolutionary biology microbes have long been recognized as key to the ability of plants or animals to explore resources in their environment and there is now growing recognition that microbionts should be considered an integral part of their host the holobiont theory state that a plant or animal cannot be considered as an individual organism but as a holobiont consisting of the host and the sum of all its microbionts and that adaptive genomic changes in the holobiont also includes changes in its microbiont community the range of microbionts a species is able to associate with through time and space has been suggested to be correlated to host adaptability to different environments and could thus be an important component in distribution patterns in plants in this project i aim to establish the association between wild plant genomes their microbiont communities and their habitat use using orchids and their associated microbiomes as a model system i will generate bacterial and fungal metagenomic profiles from tissue samples from orchids and couple it with host genomic variation to i explore the link between individual plant genotype and microbiont community profile using individual level sampling from two closely related orchid species ii measure differences in range and variability of microbiont community among 20 congeneric wild orchid species and iii correlate specieslevel diversity and variability of microbiont community with distribution range and habitat diversity in 20 congeneric orchid species the results will impact our general understanding of the importance of plant microbiomes in determining their adaptive and evolutionary success and provide important knowledge on factors effecting plant distribution of high relevance in nature management and conservation of threatened plant species
clean aviation support for impact monitoring

the claim proposal main highlevel objectives are1 to obtain an answer on how to best translate the clean aviation programme objective to reduce net greenhouse gas emissions by 30 versus state of the art into tangible metrics in terms of measurable engine tailpipe emissions bya collecting analysing and establishing the current level of scientific understanding within the worldwide community of climatology and atmospheric sciences and of aviation climate impact and its greenhouse gas emissions contributionsb identifying knowledge gaps barriers and needs for research in view of orienting more appropriately the technology research streams for future green and zeroemission aircraft2 to compile an inventory of relevant aeronautical advanced research activities and technology areas not only from the aviation community but potentially also from other sectors if relevant bya reviewing and analysing aeronautical literature on disruptive aircraft concepts or greener aircraft as well as on climateneutral aviation in general including their preliminary environmental performanceresultsb proposing a way forward and an approach that highlights the assumptions and metrics used to reconcile the numbers and the prospects of performance improvements for the main technologiesc categorising these concepts in terms of aerodynamics structural systems and propulsion technologies and their associated benefits at aircraft level as well as performing a technology mappingd performing a preliminary performance assessment using proposed assumptions and criteria for an smr and an herconsequently through achieving its objectives the claim proposal assists clean aviation ec and easa by providing more clarity and contributing to all of the expected outcomes