Dragon09/odtu_chatbot huggingface dataset:
industrial technologies and materials for sustainable europe

conference industrial technologies and materials for sustainable europe is planned in krakow on june 24 2025 as part of the polish presidency of the council of the european union it will be organized by the mineral and energy economy research institute polish academy of sciences igsmie pan the division of strategic research and malopolska voivodship mv major topics and themes will be consulted with the ministry of science and higher education which will also participate in event fundingthe scope will cover aspects of sustainable industrial technologies and materials it will be organized as a cyclical flagship event of the european union euindtech2025 under the program of horizon europes cluster 4 digital industry and space the conference will mobilize key players worldwide around the theme of the industrial technologies of tomorrow gathering stakeholders from scientific and research units industrial companies startups european partnerships administrative bodies and ngoseuindtech2025 will focus on increasing the competitiveness and resilience of the eu industry and its transformation having regard to the most important strategic developments in the area of manufacturing netzero industry critical raw materials and advanced materials
enhancing endogenous regenerative response in mammals by redeploying cranial neural crest cells pluripotency developmental programs and positional identity remodeling

cell differentiation progresses via a continuous lineage restriction process where cell potential is reduced as the embryo develops pluripotent embryonic cells can beget all somatic cell types but this capacity is rapidly restricted during the formation of the three germ layers each giving rise to distinct cell types uniquely among vertebrates a stem celllike population arising in the embryo rostral part called cranial neural crest cells cncc challenges this paradigm cncc not only give rise to ectoderm derivatives such as neurons and glia but also to cell types canonically associated with the mesoderm such as bone and cartilage of the face during my postdoctoral training i demonstrated that murine cncc naturally reverse cell differentiation to return into a pluripotent state during development in addition i showed premigratory cncc carry positional information reflective of their spatial origin in the neuroepithelium however this identity is subsequently erased with migratory cncc forming a transcriptionally homogenous population which later rediversifies as cncc undergo commitment events in my research proposal using singlecell transcriptomics and genomics assays i seek to uncover and characterize gene regulatory networks and chromatin rearrangements regulating the reemergence of pluripotency programs within cncc and the underlying reprograming of cellular identity cncc represent a unique model to study the molecular mechanisms governing cellintrinsic behavior but also the role of the niche which may influence the sequence of events by cellcell interactions during craniofacial ontogeny the interdisciplinary scope of experimental strategies included in this proposal will help understand how these fundamental processes are regulated and might result in novel strategies to stimulate craniofacial tissue repair as cell dedifferentiation and reconfiguration of positional identity are two essential milestones for endogenous regeneration
golgitacs targeted degradation of golgi apparatus residing carbohydrate processing enzymes

oligosaccharides and glycoconjugates a hugely diverse class of biomolecules are closely associated with health and many diseases carbohydrate metabolism relies mainly on glycosidases and glycosyltransferases which are carbohydrate processing enzymes cpes that break and create glycosidic bonds respectively controlling their activities is vital for understanding pathological processes in and developing therapeutics for glycanrelated diseases recently new targeted protein degradation tpd technologies which disable diseaserelated proteins by degradation have opened possibilities for proteins that are otherwise hard to inhibit while tpd within the cytoplasm cell membrane and extracellular space can be achieved with current approaches proteins in the golgi apparatus can not be degraded by means of the current methods yet it is a major cellular compartment where most cpes reside new tpd strategies targeting golgi apparatusresident proteins would be a major solution for cperelated diseases with unmet medical needs sweet degradation aims to develop strategies that allow for the first time the degradation of proteins located in the golgi apparatus opening ways for a new therapeutic modalitythe driving idea behind this proposal is that a molecule can be designed thatselect cpes in the golgi for targeted protein degradation such molecules which i term golgitacs will link a cpe to a golgi transporter either sortilin or cationindependent mannose6phosphate receptor cim6pr and shuttle cpes to the lysosome for degradation in aim 1 i will focus on developing the golgitac technology whereas in aim 2 golgitacs will be exploited for targeted protein degradation of cpes in disease models in all sweet degradation will deliver a conceptually new general strategy to target golgi proteins for degradation thus providing new inroads to develop therapeutics for currently untreatable diseases
breaking down barriers to foster new cyclodextrinbased applications for healthcare by implementing sustainable design principles

cyclodextrins cd have already gained several market applications as excipients in drug and vaccine formulations they are very appealing platforms for the development of therapeutic applications and new cdbased systems are continuously proposed in this frame easily prepared cd polymers frequently outstand the performance of the corresponding cd monomers nevertheless application of new cds as drug or delivery system in the clinics does not take off in spite of their most promising features this is mainly due to a lack in transfer of knowledge between the academic world and the private sector focusing on cd for biomedical applications the consortium formed by a multidisciplinary team all with interest in cd and nanomedicines accepts the challenge to bring cdbased systems closer to clinical application to reach this goal an intense secondment scheme for young and experienced researchers is envisaged with activities that are all contributing to the scientific pursuit of cd progress activities focus on the design of sustainable syntheses of new cd full characterization of new functionalized cd the preparation of cd delivery systems for therapeutics and the study of the biological behavior of the cdbased nanomedicines in 2d and 3d models the teams will embrace already from the design stage the production standards affording compliance with gmp for medicine development and prefer strategic approaches in line with the eu 2030 agenda for sustainable development the consortium features 11 partners with 4 coming from the private sector two of them hold concrete interest in the exploitation of research results as their core business focuses on cd for biomedical applications this intersectoral and interdisciplinary team will foster new applications of cdbased systems as drugs delivery systems or sensors and participating staff will enrich their profile with scientific and soft skills that are easily transferred to other research topics or sectors
threedimensional integrated photonicphononic circuit

the coherent optomechanical interaction between acoustic and optical waves known as stimulated brillouin scattering sbs can enable ultrahigh resolution signal processing and narrow linewidth lasers important for nextgeneration wireless communications precision sensing quantum information processing and many more but the proliferation of such a unique and powerful technology is currently impeded by fundamental challenges associated with circuit integration of brillouin optomechanics in a versatile and mass producible material platform such as silicon nitride the absence of acoustic guiding and the infinitesimal photoelastic response of standard silicon nitride devices render conventional sbs in this material platform currently out of reach an innovative approach that breaks with usual paradigms of actuating sbs solely through optical forces in twodimensional waveguiding circuit is required to overcome these fundamental limitations the triffic project aims to actuate and subsequently functionalize sbs in silicon nitride through threedimensional 3d integration of gigahertz acoustic wave sources and waveguides with low loss optical circuits the two orders of magnitude sbs gain enhancement expected from this project will unlock brillouin optomechanics in silicon nitride circuits for the first time using this novel 3d optomechanical platform i aim to demonstrate a revolutionary concept of ondemand and programmable optomechanics that will transform the field of rf photonics by providing an advanced signal processor with comprehensive spectral control beyond what is currently possible further i will demonstrate hzlinewidth integrated sbs lasers in the red and blue visible wavelengths that can be integrated with future portable optical atomic clocks and trapped ion quantum computers the erc consolidator will be instrumental for me to achieve these ambitious research objectives that will enable the optomechanics revolution in integrated optics
additive manufacturing and advanced materials competence centre in cyprus

advancing capabilities and elevating the profile of the university of cyprus ucy through the establishment of an additive manufacturing and advanced materials competence centre in cyprus am2c3 will increase the potential for excellenceinresearch and promote the growth of the knowledgeeconomy in a widening country additive manufacturing is transforming and decentralizing the aerospace industry sector which is described by lowvolume yet highvalue applications the transformation is accommodated by the development of advanced materials and designs especially almetal matrix composites with superior specific strength twinning of the ucy with three internationallyleading partners will facilitate knowledgetransfer that focuses on processing methodologies and characterization techniques of am consolidated albased mmcs advanced partners imdea spain sintef norway and empa switzerland will participate in training activities directed towards ucy researchers and host staff exchanges aimed to buildup new competencies such activities will guarantee access to sophisticated equipment and infrastructure but also enhance research output to further stimulate excellenceinresearch and maximize impact the centre will encompass a variety of networking activities to reach an audience in academia industry the general public and policy makers in more detail these activities include round table discussions with policy makers working groups with industry stakeholders international symposium with experts of the scientific community and summer schools for students in general terms this multidimensional approach aims to sustainably integrate and anchor the competence centre on a local and international level and in turn establish an exploitation framework of intellectual property the adoption of technical knowhow in am technologies and the project supportnetwork will thereby become the foundation for future activities of am2c3
correlated ion electron for nanoscience

electron and ion beams have become indispensable tools in surface and materials science many applications rely on extreme miniaturization like in nanostructuring and doping which imposes to control the energy the number and the locations of electrons or ions at the nanometric level the citron project aims at achieving breakthroughs in focused ion and electron beams exploiting monochromaticity in the lowenergy domain evkev to reach such a fine level of control of the sources of charged particles in contrast with standard tools the proposed developments rely on the ionization of a neutral atomic species and on the simultaneous production detection and control of both the ion and the electron such a detection in coincidence yields correlated information on both particles that can be used to improve the beam properties like the deterministic knowledge of the creation of the charged particles and the correction of their trajectories in real time using this novel technique which i have recently demonstrated the feasibility with my group i propose to develop three innovative prototypes 1 a focused ion beam using feedback control with unprecedented focused properties i will used it to realize semiconductor circuitediting at the subnm scale2 a deterministic source of potentially any type of ion for controlled implantation at the nm level i will use it for ondemand doping of quantum devices3 a highresolution electronenergyloss microscope with precise knowledge of the electron energy and the position on the sample i will use it to realize both imaging and vibrational spectroscopy for surface analysisthe synergy between the three prototypes is based on atomic beam laser excitation to create a monoenergetic beam of charged particles with energy and position controlled by correlation between oppositely charged particles all will require dedicated optical columns designs and fast time and position sensitive detectors
plasticity of neurotransmitter release sites in temporal coding homeostasis learning and disease

virtually all neural computation relies on synaptic plasticity the dynamic change of chemical synaptic communication achieved by transmitter exocytosis from vesicles at presynaptic release sites to activate postsynaptic receptors plasticity mechanisms must be powerful scalable and sustainable over all timescales of neural processing which part of the synaptic machinery is the best suited plasticity target the number of synaptic vesicles greatly outnumbers that of release sites essentially making the sites gatekeepers of all neural communication release site plasticity could thus be pivotal to all neural processing we recently discovered the molecular identity of release sites conserved unc13 proteins and found evidence of potent release site plasticity on timescales of milliseconds minutes and days we are now in the position to use this molecular handle to unravel the principles of this plasticity which will be key to understand neural function behaviour and diseaseowing to the conserved process and machinery we will harness the power of drosophila genetics to elucidate general mechanisms and broad relevance of three distinct releasesite plasticity phenomena1 release site switching for millisecond facilitation of transmission and its contribution to network pattern generation as needed for locomotion2 release site activation for minutes potentiation of transmitter release and its role in homeostasis and learning3 release site accumulation for longlasting potentiation with regained dynamic range and its role in homeostasis and memoryfinally disease mutations accumulate in proteins relating to release site function we will thus 4 investigate whether these mutations affect release site plasticity in flies and attempt treatment of their induced defects by artificial enhancement of plasticity my work will set the stage to establish the investigation of the role of this novel and fundamental plasticity in neural function and disease
quantum microwave detection with diamond spins

microwave detection is one of the most widely spread technologies in our society spanning across areas as diverse as telecommunications computers radioastronomy navigation and air traffic control spectroscopy and medical diagnostics in this proposal we address emerging and advanced mw applications that start from the same basis a need for ultrasensitive detection with a high spectral resolution and in addition requesting portable integrated instruments emerging quantum technology devices acting as sensors can lead to a major breakthrough in the application field through high sensitivity and frequency resolution in qumicro we propose to develop a quantum technology for the next generation of microwave detection devices surpassing the capabilities of all currently available methods the devices will enable the rapid measurement of the frequency amplitude and phase of microwave fields we will achieve extremely fast nanosecondscale transient detection a broad detection range spanning tens of gigahertz and partspermillion frequency resolution with ultrahigh sensitivity the qumicro system is based on a novel detection scheme and on the pioneering innovation concept of photoelectrically detected magnetic resonance with nitrogenvacancy colour centre qubits in diamond as a highly performant platform for microwave signal detection at room temperature we will start our developments from a theoretical framework for quantum microwave sensing protocols and devices and leveraging schemes based on manybody quantum correlations implemented in qumicro engineered devicesto achieve these goals qumicro will connect with scientists and engineers across a broad range of topics the photoelectrical readout guarantees compatibility with scalable semiconductor electronics providing a direct outlook towards commercial applications and a sciencetotechnology leap for microwave sensors with unrivalled performance
life and death war and peace c1550c1700 voices of women in early modern ireland

voices aims to recover the voices and interrogate lived experiences of women in early modern ireland ireland formed part of the british european and atlantic world and women there responded to similar sets of transformative processes as other early modern women protoglobalisation state formation confessionalisation warfare commercialisation environmental change and so on which facilitates interrogation that is comparative connected and entangledtwo ambitious research questions underpin this pioneering project which focuses on ireland as a case study 1 what role did women play in a society undergoing profound economic political and cultural transformation 2 what were their experiences of recurring social upheaval bloody civil war and extreme trauma especially sexual violence and how have these been politicised our novel approach derives in large part from the interrogation of previously inaccessible historical data now available digitally this windfall is exceptional but the resulting data is unstructured innovative technologies transform this unstructured data into knowledge that can be interrogated and visualised voices will then transform the field of history by allowing us to recover the marginalised voices lifecycles and identities of women in ireland and assess their contribution to the household regional and national economies and relationship to the land wps1 2 situate the experiences of women in the broader analytical framework of europe britain and the atlantic world wps14 lay the foundations for further future scholarship on the family gender identity memory emotion and trauma in the early modern period wps14 produce ontologies that outline key concepts and entities that relate to women and violence that can be reproduced across time and place which makes voices the exemplar of the new and longstanding research questions now answerable by digitisation and associated methodologies wp0
pdi connectivity and cooperation enablers building trust and sustainability for ccam

in podium using and enhancing the facilities of 3 wellequipped living labs in germany italy and spain we define a rich set of demanding ccam ucs to identify and assess all the connectivity and cooperation enablers and needs that will allow the proposed higher levels of automation building on the proposed ucs urban and highway incl crossborder setups which will be demonstrated and validated in reallife conditions podium will tackle all the different requirements for availability and performance of connectivity as well as the different cooperation enablers per uc the proposed ucs aim to advance a set of key technologies both in the physical and digital part of the infrastructure a multiconnectivity approach is followed to ensure reliability availability and redundancy of the pdi system ie itsg5 5g lte 5g mmwave 60ghzwifi etc as part of the proposed pdi system a distributed interoperable and hybrid mec and cloudbased data management environment will be implemented which will include suitable advanced environment perception models and digital twins to facilitate seamless and efficient exchange of data in low latency thus enabling realtime analytics and opening up new business opportunities software integrity and data truthfulness of external data are important aspects that will be considered throughout the pdi to address existing gaps new and standardised cits messages will be integrated to support advanced functionalities whereas new designs of rsus and obus will allow advanced environmental modelling and digital twins based on locally generated data last but not least a major focus will be laid on the integration of vrus in the overall pdi all those elements will be integrated under the umbrella of the three layered podium reference architecture which is flexible and applicable in different road environments based on the available infrastructure equipment enabling different kinds of services
how hands help us hear

human communication in facetoface conversations is inherently multimodal combining spoken language with a plethora of multimodal cues including hand gestures although most of our understanding of human language comes from unimodal research the multimodal literature suggests that hand gestures are produced in close synchrony to speech prosody aligning for instance with stressed syllables in freestress languages like english furthermore prosody plays a vital role in spoken word recognition in many languages influencing core cognitive processes involved in speech perception such as lexical activation segmentation and recognition consequently viewing gestural timing as an audiovisual prosody cue raises the possibility that the temporal alignment of hand gestures to speech directly influences what we hear eg distinguishing object vs object however research to date has largely overlooked the functional contribution of gestural timing to human communication therefore hearinghands aims to uncover how gesturespeech coupling contributes to audiovisual communication in human interaction its objectives are wp1 to chart the prevalence of the use of gesturespeech coupling as a multimodal prominence cue in production and perception across a typologically diverse set of languages wp2 to capture the variability in production and perception of gesturespeech coupling in both neurotypical and atypical populations wp3 to determine the constraints that govern gestural timing effects in more naturalistic communicative settings these objectives will be achieved through crosslinguistic comparisons of gesturespeech production and perception neuroimaging of multimodal integration in autistic and neurotypical individuals and psychoacoustic tests of gestural timing effects employing eyetracking and virtual reality thus hearinghands has the potential to revolutionize models of multimodal human communication delineating how hands help us hear