Dragon09/odtu_chatbot huggingface dataset:
harnessing the cognitive and neurophysiological processes characterising the sleep onset period

sleep often escapes us when we need it or intrudes when we would prefer to stay awake what if we could control when we fall asleep while our understanding of sleep has rapidly grown what happens during the wake to sleep transition remains mysterious potentially due to the widespread assumption that we are either awake or asleep the current standard is to define vigilance states through coarse physiological criteria that are visually assessed on fixed 30sepochs in this framework the sleep onset period sop typically corresponds to the first sleep stage yet this classification in discrete sleep stages fails to account for the gradual dynamic changes observed in the descent to sleep on the behavioral reduced responsiveness to stimuli subjective dreamlike experiences called hypnagogia and cognitive level decline in executive functions enhanced creativityto better understand how we transition from full vigilance to sleep i propose to integrate within the same framework the many dimensions of the sleep onset process i hypothesize that the behavioral subjective and cognitive changes associated with the sop are each reflected by specific neurophysiological signatures that are partially independent of sleep stages i recently found candidate physiological markers for the different sop dimensions in creadoze i will leverage on these findings to refine in space and time the neurophysiological signatures reflecting the processes which decline behavioral responsiveness executive abilities and those which emerge hypnagogia creativity during the sop using multimodal physiological recordings i will explore how these markers fluctuate in relation to each other and identify potential factors influencing them sleep pressure sleep disorder then i will use neurofeedback to train individuals to either resist or embrace sleep if successful this proposal will open the possibility to harness the sleep onset period depending on ones needs
deepsea fish vision pushing limits of the vertebrate eye

deepsea fishes are known for extraordinary adaptations including enhanced sensory systems they have eyes often modified in shape anatomy or at the molecular level fascinatingly some deepsea fishes have evolved unique vision to potentially see colours here i propose to study functional evolution of this visual system and to target the crucial question can deepsea fish see in colours to perceive light vertebrate retina has two types of photoreceptor cells the rods for dimlight vision and cones for daylight colour vision many deepsea fish lack cones which makes them colour blind the novel visual system based purely on multiple different rod opsins possibly overcomes this limit and it is not found in any other vertebrate in sensingdeep i aim to zoom into the level of single rodcone cells to understand deepsea molecular adaptations of vision i will target species with 1 the novel multiplerhodopsin visual system and test if it has a potential to serve for colour discrimination with multiple rhodopsins expressed in the retina singlecell transcriptomics will either reveal rod cells sensitive to different colours or alternatively superpowerful rods sensing along the entire light spectrum both options would be unique among vertebrates further i aim to focus on the deepsea species with 2 challenged rod and cone cell identity with mismatch of molecular machinery of both rod and cone types lastly i will also test 3 how rare these extreme adaptations are in deepsea fish diversity using the highquality wholegenome sequencing in the species with multiple rhodopsins i will specifically focus on their genomic architecture and gene regulation by applying singlecell multiomics sensingdeep combines modern genomic tools with rare and unique samples given that vertebrate eye is a conserved structure the deepsea fish with extreme adaptations will therefore serve as a model to explore and push the limits of vertebrate vision
the world is bigger than five identity discourse and the transformation of turkeys foreign policy since 2011 idandtfp

idtfp examines turkeys foreign policy reorientation during the 2010s and contributes to academic debates on foreign policy transformation and foreign policys role in domestic politics during the justice and development party akps first decade in power it prioritised turkeys european union eu membership and sought to increase turkeys influence through soft power instruments however soon after the arab spring protests broke out in 2011 the akp began asserting its ambition to shape the middle east in its vision by supporting political actors affiliated with the muslim brotherhood in egypt libya and syria it has been portraying turkey as the leader of the muslim world championing the palestinian cause building an international coalition to combat islamophobia and calling for the reform of the international order idtfp seeks to understand a why a reorientation was perceived as necessary and possible by the turkish decisionmakers and b the role it has been playing in the akp governments efforts to change the domestic order in its attempt to extend its religiousnationalist hegemony over turkish politics it connects foreign policy and domestic politics through a focus on identity and offers to study a wide range of primary sources to understand the articulation of turkish identity in the foreign policy discourse and to explain how identity has been instrumentalised in domestic politics through the case study idtfp explores why and how foreign policies transform and how foreign policy is used to establish and stabilise a domestic political order which are issues central to foreign policy analysis idtfp also contributes to the literature on discursive policy analysis by providing a critical explanation of why particular policy discourses become dominant how they contest the dominant orders and understanding of how support for or compliance with certain policies is generated
a smart centrifuge camera for testing dewatering ability of wastewater sludges in hypergravity

the eu produces more than 45000 tons of wastewater sludge per day as byproduct of municipal and industrial water purification activities this enormous amount can become a gold mine for materials recovery or an environmental burden depending on how well wastetreatment plants can remove water from these sludges today sludge treatment processes are based on unoptimized methods which rely on operator experience and lowtech equipment and are not able to deal with the fastchanging sludge type evolution resulting in loss of time energy and money as well as a negative environmental impactthe sludgecam project will deliver an innovative smart camera centrifuge having advanced software hardware and sensing features which will enable plant operators to consciously adapt treatment process parameters select flocculant polymers and set standards for different sludge types based on solid reproducible data so that more environmentallyfriendly water treatment operations and drastically reduced energy consumption for sludge incineration will be achieved
driving tumour antigen presentation by rnamediated transdifferentiation

immunotherapy has transformed cancer treatment but targeting effectively refractory solid tumors remains a challenge due to poor t cell activation downregulation of antigen presentation pathways and lack of professional antigen presenting cells in the tumor microenvironment contribute to immune evasion my group has demonstrated direct reprogramming of fibroblasts or tumor cells into type 1 conventional dendritic cells cdc1 cells by overexpression of the transcription factors pu1 irf8 and batf3 moving towards clinical application via a viral gene therapy despite its potential for firstinclass therapy viral approaches still face limitations including inefficient targeting of solid tumors in vivo and challenging scalabilitythe dart project builds on the ercfunded project trojandc and aims to develop in vivo reprogramming of tumor cells into cdc1like cells using rna vectors i will firstly evaluate the capacity of modified linear selfreplicating and circular rna encoding the factors to reprogram fibroblasts in vitro and assess their antigen presentation and cytokine secretion function secondly i will evaluate rnamediated reprogramming of cancer cells and assess antitumor immunity in vivo as monotherapy and in combination with immune checkpoint blockade the goal is to optimize rna vector designs for the most effective in vivo reprogramming considering differences in delivery efficiency expression kinetics and immunogenicity collaborations with clinicians and industry partners like asgard therapeutics are integral ensuring commercialization through novel intellectual property broad dissemination and product developmentdart will enable rnamediated induction of antigenpresenting phenotypes in cancer cells leading to potent and specific immunity towards tumorspecific antigens dart will result in an offtheshelf safe and scalable immunotherapy solution that also has the potential to enhance current immunotherapy approaches
co2 fixation and energy conservation in the ancient woodljungdahl pathway

carbon dioxide co2 receives a lot of attention as a greenhouse gas that promotes humaninduced climate change on the other hand co2 is also the starting point for the production of virtually all biomass on our planet therefore nature has developed sophisticated methods to fix co2 and make it available for biochemical reactions of all known biological co2 fixation pathways the woodljungdahl pathway wlp is the simplest way to fix two co2 molecules to form acetylcoa the key metabolic intermediate for biomass formation it is the only pathway directly related to energy conservation and regarded to be the be the most ancient the twoco2one project aims to gain a comprehensive structural and mechanistic understanding of co2 fixation and energy conservation in acetogenic bacteria and methanogenic archaea these ecologically highly relevant organisms can live under conditions of extreme energy limitation in the absence of oxygen and feed exclusively on co2 and hydrogen i will elucidate how these species fix co2 and conserve energy through their wlp by using the innovative structural approach of redoxguided cryogenic electron microscopy cryoem to study the oxygensensitive metalloprotein machinery of the wlp the mechanistic insights gained will be challenged by microbiological and genetic approaches in these anaerobic nonstandard model organismsusing autotrophic organisms that can sequester gaseous co2 to produce biogas or ethanol from abundant waste gas resources is one way to reduce the human carbon footprint therefore the twoco2one project will not only lead to a deeper understanding of the unique mechanistic principles of wlp but also provide new perspectives for developing biotechnological applications based on improved microbes that capture and sequester co2 to produce industrially relevant chemicals and to combat humaninduced climate change
2d tmldh layered double hydroxide with low dimensions materials mxene graphene and tmc as flexible solid state and electrochemical supercapacitors and electrocatalyst

two dimensional 2d materials and their composites are now in trends due high electrocatalytic activity and ion storage capacity the development of costeffective and simple electrocatalyst for energy applications are still challenging the best substitute to typical transition metal oxideshydroxideschalcogenides tmostmhstmc for electrocatalysis is transition metal based layer double hydroxide tmldh layer double hydroxide materials have various benefits including low cost chemical composition variety easily manipulated characteristics a wide range of preparation variables unique anion exchange and intercalation properties chemical stability and colloidal and thermal behaviour but the fewer active sites and poor electronic conductivity of layer double hydroxide restricts their applications here the proposed work has the purpose to contribute to the expansion of electrocatalysts that are effective in a variety of energy applications the main focus is to develop hierarchical structure of layer double hydroxide composition of layer double hydroxidetransition metal chalcogenides and layer double hydroxidecarbon based materials adopting various methods such as hydrothermalsolvothermal liquid phase exfoliation and electrodeposition the technique appears to eliminate hurdles related to electricalionic conductivity and surface morphology resulting in a bifunctionaltrifunctional electrocatalyst that is effective for wearable supercapacitor and overall water splitting
multipoint megawatt charging for battery electric truck hubs

the transition to electric longhaul trucking facilitated by megawatt charging systems mcs is essential for the efficient decarbonization of the logistics transport sector despite the significant technological progress made vital challenges for full adoption and scaling of the mcs systems are still to overcome addressing the latter though targeted research and innovation piloting activities will be crucial for realizing the full potential of mcs technology towards a significant leap not only in electrifying the commercial transport but for the achievement of broader environmental goals of the paris agreement eu green deal and fitfor55 package of 90 reduction of the emissions by 2040 in response to the challenges macbethmultipoint megawatt charging for battery electric truck hubs aims to pilot and showcase usercentric mcs charging hubs combined with tools that can facilitate the rapid and mass deployment and scale up of such systems in europe to address many of technical social and economic challenges of mass deployment of megawatt chargers macbeth intends to build two demonstration sites in nordics and benelux area of europe with the intention to cover various geographic contexts operational conditions and scenarios users needs and business cases and provide valuable experiences and learnings for various industrial research and policies stakeholders for future deployments with a strong focus on its industrial cluster macbeth contributes to the realworld demonstration of charging infrastructure and service offerings for regional and longhaul electric trucks along tent corridors logistic terminals and depots covering multiple countries and it is set to deliver systemlevel multipoint mcs hub concept at technology readiness level trl of 8 by the end of the project
flamemade calcium phosphate nanoparticles for biological drug delivery toward healing chronic wound

the increasing number of chronic wound cases most frequently attributed to antibioticresistant bacterial infections has set an urgent alarm since it causes low quality of life and even fatal complications to thousands of patients as well as burdens the healthcare systems globally antimicrobial biological drugs also called biologics are proposed to address the emerging and unmet threat of antibioticresistant bacteria in wound infections by developing antibioticfree treatments with low immunological risk despite having maximal antimicrobial effect biologics efficiency in infection treatment and wound healing is compromised due to their limited circulation halflife and susceptibility to environment and wound related factors hybrid nanoformulations hns based on inorganic nanoparticles nps are developed to perform biologics delivery by securing the integrity of their vulnerable structure and efficiency while they exhibit great potential in biomedicine as drug nanocarriers due to their stability small size and extremely high surface area here we propose the synthesis of biocompatible and healingpromoting calcium phosphate cap nps with a nanomanufacturing process famous for its scalability and reproducibility flame spray pyrolysis the asprepared cap nps will be loaded with the biologics peptide ll37 and enzyme lysozyme to form novel hybrid drug delivery nanosystems synthesis parameters of cap nps and hns nanomanufacturing protocols will be studied and their physicochemical characterization will be performed the stability the antimicrobial activity and the cytocompatibility of the hns will be examined with invitro assays finally the effectiveness of hns in wound infections treatment and wound healing promotion will be tested exvivo this project will provide fundamental insights on biological drug loading parameters on nanocarriers to facilitate rapid translation to clinics after the intellectual property is protected
metastable smart metamaterials for activelycontrolled and reversible transition waves

mechanical metamaterials play a crucial role in various applications such as shape morphing soft robotics and logic elements however the control and guidance of transition waves within these materials have primarily been static the metasmart project aims to revolutionize this by actively controlling and guiding transition waves using piezoelectric and shape memory polymerbased multimaterial active switches integrated into metamaterial unit cells unlike traditional methods metasmart offers dynamic and reversible control allowing the metamaterials to adapt autonomously and universallyto optimize these smart metamaterials we will implement a machine learningbased inverse design strategy to determine their geometrical parameters fabrication will involve 3d printing followed by experimental testing of transition wave control and guidance this innovation promises to advance the industrial applications of mechanical metamaterials offering adaptability to external forces and desired outcomes potential uses include controlled energy absorption and dissipation for airflow control in aircraft selective energy absorption in protective surfaces and even treatment of parkinsons diseasethe metasmart project represents a valuable opportunity to expand my expertise in smart materials and structures enhancing my research profile through handson experience in testing and fabrication training activities such as tu delfts teachers training program workshops on supervising research projects and advanced courses in machine learning and 3d printing will equip me with the skills needed for a successful academic career in the smart materials and structures field aligning with my longterm goals
materializing renewable capital

the international energy agencys recent net zero by 2050 report concludes that by 2030 four trillion usd of annual global investment into clean energy is needed to avert catastrophic climate change yet in the last four years such investments have averaged just one trillion critical economic geography has emphasized the role of nonprice factors in this renewable investment gap materializing renewable capital marc advances this inquiry through a survey of how the materiality of the production process for 14 key components of the transition interlink with and inform renewable capital mobilization from energy financing firms marcs objective is to 1 survey the materiality of key renewable production processes 2 assess how investors view the relative quality of these processes 3 create an integrated analysis of how their materiality relates to capital accumulation 4 create a future research program empirically marc achieves these objectives through parallel surveys involving interviews and desk work first of the materiality of these production processes second of the financial logic driving capital accumulation in these processes three papers will result results will also be communicated through a website an online video and 3 articles in the popular press marc combines the extensive experience of the researcher in energy with the worldclass expertise of the supervisor prof brett christophers in finance additional support from uppsalas earth science department will ensure the success of this innovative interdisciplinary project this project will substantially improve the researchers career prospects especially given the outstanding trackrecord of the supervisor with postdocs multiple points of advising and rich support from uppsala university the host in turn will benefit from the researchers outstanding teaching seminars and an interdisciplinary workshop on the renewable investment gap
quix quantum universal quantum processor

quantum computing is a technological revolution that will unleash the most dramatic changes in our everyday lives since the invention of the internet quantum computing has the power to impact every major global industry from pharmaceutical research to climate action and personalized healthcare to space travel however todays quantum technologies still suffer several drawbacks they require cumbersome and rigid hardware such as cooling to almost absolute zero and suffer from both noise and decoherence quix quantum is bringing to market the first scalable universal quantum processor based on our disruptive photonics innovation for the first time we will be offering a scalable marketable universal quantum processor that can be adopted by companies research institutes and government organizations to change the world in which we live we are seeking eic support in the form of blended finance to bring our first universal quantum processor product to market as early as 2026
novel bioelectrochemical factory system for energy production and treatment of industrial wastewater electroactive and nonelectroactive microbiome

the overarching objective of the mfcbiofactory project is to develop and evaluate a microbial technology for the treatment and generation of electrical energy using wastewater from the canned food industry and to characterize electroactive eams and nonelectrochemicallyactive noneams microorganisms involved in energy production and reduction using metagenomic sequencing and specific marker genes a novel biofactory system that produces zero greenhouse gas ghg emissions zero energy consumption and allows the valorisation of the generated waste known as a microbial fuel cell mfc together with a photobioreactor microbial fuel cell biofactory mfcb will be developed the metagenomic microorganism characterization will be used to optimize the performance of the electrochemical biofactory system this project will allow the establishment for the first time of circular economy in the biological treatment of industrial wastewater that is difficult to treat and has a high salinity thus contributing to the un sustainable development goals green deal msca green charter and uns sustainable development goals the mfcbiofactory involves a multidisciplinary research team including researchers and industry professionals dedicated to process engineering bioelectrochemistry applied microbiology and chemistry