Dragon09/odtu_chatbot huggingface dataset:
dynamic river catchments in a global change context assessing the present preparing for the future

in a global changing world sediment regime has emerged as a dominant actor in the modification of river catchments the sediment regime refers to the sediment budget amount type and timing of sediment inputs outputs and storage of a river system as well as the way water and sediment interact to drive river conditions studies of sediment regime assessing the impact of global change are scarce and traditionally relies on deterministic approaches however at any given river catchment section a complex imprint in the spatialtemporal distribution of sediment regime is observed this imprint is caused by the temporal and spatial uneven production storage activation and transport of sediments pure deterministic and thus partial solutions are not accounting for the natural variability of sediment regime and the inherent uncertainty due to global change this means we are potentially missing half the story and that our attempts to forecast the current and future evolution of rivers areas at both catchment and reachscale may be more wrong than right the tenet of this proposal is to describe and determine the global change impacts on sediment fluxes at all scales relevant for river catchment management by means of a modelling approach that can account for natural stochasticity and global change uncertainty three main and novel research questions have been identified and need to be addressed i how and how strongly the headwaters control the main features of sediment regime ii how to model sediment fluxes by means of a forecasting model capable to reproduce fluctuating and thus realistic sediment regime characteristics and iii how to identify and incorporate the global change impacts on sediment regime modelling to assist in fostering a more robust river catchment management this proposal contributes to the 13th un global goal climate change and to the horizon europe mission adaptation to climate change including societal transformation
fostering a recycled european silicon supply

the project foresi aims at fostering a recycled european silicon supply through the first worldwide industrial demonstration of a cradletocradle silicon value chain to contribute to a sustainable energy sovereignty for europe foresi will demonstrate a circular recycling process from endoflife pv panels towards new photovoltaics and ev batteries applications the project will demonstrate the technical economic and environmental viability of the entire recycling process and deliver the design of an optimised recycling turnkey factory of endoflife pv panels paving the way for a european industrial mass production of recycled silicon foresi will also develop an online integrated platform for recovery of pv panels and deliver a pv testing methodology to reuse and repair eol pv modules
potato crop effective management strategies to tackle future pest threats

potato is a key crop in europe 124 billion 2020 however it is considered vulnerable to a variety of pests and soilborne pathogen diseases one of the most important pests is caused by bacteria candidatus liberibacter solanacearum clso causing a disease known as zebra chip zc the introduction of clso bacterium on potato is mainly linked to the presence of the vector psyllid bactericera cockerelli bc causing severe damage both in terms of yield losses and quality main potato postharvest diseases as dry rot black dot and silver scurf are caused by soilborne pathogens that have incidence in both field and storage all these potential threats may result in significant economic losses in the potato industry and food losses the european regulatory framework for potatos imports and production is very strict however globalisation climate change economical drivers as well as the political context eu green deal target of 50 pesticides reduction are threatening the entrance of emerging potato pests and the incidence of soilborne pathogen disease in postharvest storage patafest and its 18 complementary partners including the international cooperation with ecuador aims 1 to characterise at molecular level the ecological pest spread pathway and identify potato disease resistance varieties against clso and postharvest pathogens 2 provide effective preharvest plant and soil treatments against clso vector and soilborne pathogens combined with other cuttingedge digital technologies such as image analysis tools mobile app and artificial intelligence predictive models 3 develop postharvest technologies biocontrol coating solution controlled atmosphere storage and volatile organic compounds vocs sensors to control the incidence of soil pathogens and maintain the quality of potato tubers stored these strategies and technologies will be incorporated into an integrated pest management approach to evaluate their performance at final trl5
towards a leading europe in breakthrough innovation

the purpose of this proposal is to support the organisation of the 2022 edition of the week of innovative regions in europe the university parissaclay was chosen to manage organize and host the conference the general objectives of wire areto contribute to research innovation and regional development policiesto better position regional actors in order to enhance policy formation for effective innovative regional developmentto contribute effectively to the future of europe in relationship to integrative policies european added value and real interregional cooperation and coinvestmentsit will take place the 111213th may 2022 500 visitors are expected it will look for greater synergies between the eu and member state actions focusing on the priorities of the horizon europe programme 2021 2027 its headline targets and the european research area the title of the conference is towards a leading europe in breakthrough innovationbased on the fact that breakthrough innovation is a key strategic element of economic development in europe as well as on the international context the wire conference proposes a reflection in two partsthe first will be an overview of the tools available in europe for the development of breakthrough innovation especially those available at regional levels to help local developments it will include a reflection on the articulation between actions and fundings at regionalnationaleuropean levelsthe second one proposes a declination of these tools to enforce the european strategy of becoming leader in breakthrough innovation for all stakeholders at different levels and more specifically at regional levelsin this context some key topics will be addressedinnovations with potential breakthrough and disruptive nature in a regional ecosystem innovations with scaleup potential that may be too risky for private investors the questions of fundings and also the relevant level european national regional
explainable automation for continuum 6g infrastructures

g is envisioned to foster an industry revolution and digital transformation and will accelerate the building of smart societies leading to quality of life improvements providing truly immersive armrvr experiences and will help in the deployment of connected robots and autonomous systems haptic communication and smart healthcare however it also comes with a unique set of challenges due to the unprecedented capacity spectral efficiency and infrastructure flexibility requirements to this end exact6g research project aims to propose design and validate a novel and agile 6g system architecture and enabling technologies combining ris with a compute continuum infrastructure and distributed intelligent orchestration that seamlessly integrates cloud edge and far edge nodes under a selfsynthesized and selfmanaged paas system moreover exact6g will build a training network to conduct topnotch research towards the development and experimental evaluation of a gamut of techniques methodological frameworks and tools furthermore exact6g proposes new concepts such as pervasive orchestration and designs new explainable ai models for for scalable autonomous control of the infrastructure and allows microservices to follow users being tracked by joint communication and sensing mechanisms
safeguarding african foodsheds and ecosystems for all actors across local regional and international levels to manage migration

agriculture is the foundation of the livelihoods of billions of people worldwide including african rural and urban households farming communities and cities however weather and climate risks have increased creating a need for better access to climate and weather information soil water management insurance and other climateagricultural services although some services exist they are often separated and follow a topdown information provision that operates on a national scale safe4all aims to address the interconnected issues of climate change food security ecosystem and disaster management and migration in africa by providing usercentred climate services it will innovate and bundle affordable and scalable services that include locationspecific information to meet the needs of endusers in kenya ghana and zimbabwe three cocreation case studies will be organized in these vulnerable african countries engaging with smallscale farming communities municipalities and cities safe4all will coordinate efforts from governments civil society academia and international organizations to mobilize the capacity of endusers build food security and resilience promote sustainable agriculture and provide social safety nets to affected localities specific objectives include establishing a collaborative cocreation and engagement platform for the prioritization and codevelopment of needsbased climate services identifying adaptation challenges requirements and enabling factors and complementing policies in adapting to the wider socioeconomic environment and exploring and harnessing existing services to improve the uptake and effectiveness of climate services and develop sustainable business and implementation models for services the outcomes aim to manage migration to cities by ensuring that communities are better equipped to adapt and cope with the impacts of climate change while enhancing food security in a rapidly changing world
science for everyone sustainability and inclusion

science for everyone has been perceived as a motto to involve the general public especially young students with research activities and scientific knowledge that may answer to concerns related to sustainability climate neutrality and social inclusion major world and european challenges this proposal intends to directly respond to responsible research and innovation rri goals of the eu framework program by raising the public awareness also among school communities about the relevance of science to assure resources preservation decarbonization and inclusion and by bridging the gap between scientists and society giving researchers the opportunity to perceive the main concerns of citizens and how those see and understand their work schools and their students will be involved in activities during the whole project in order to ensure the impact in such communities thus by increasing public and students outreach sciever will contribute simultaneously for two main objectives i improving the understanding of the importance of scientific careers development and science investments ii increasing researchers understanding of the role of society as a whole for sustainable science policies development the consortium of this project is coordinated by the university of lisbon through the national museum of natural history and science and combines efforts between researchers of major universities in portugal including four urban areas from north to south the university of minho the international iberian nanotechnology laboratory the university of vora the university of coimbra and the lisbon university institute for the impact assessment nova university in lisbon will coordinate a special program targeting school communities and the superior school for tourism in estoril will contribute to disseminate food security practices the lisbon municipality is a central partner for the engagement of diverse audiences and civil society stakeholders
circular agrifood ecosystems bringing nutrients back to the soil

in current conventional agricultural practices most farmers depend on synthetic fertilizers and nutrients extracted during harvests are seldom brought back to the soil this opencircuit organization of food systems induces the prospect of phosphate shortage and consumes large amounts of abiotic resources and energy to generate fertilizers or process nutrients once they end up in sewage such a linear and extractive system together with current fertilizer application methods has incurred great social and environmental costs around the world leading to significant biodiversity loss soil erosion and salinisation as well as nutrient leaching finally animalbased diets in the largest economies further increase the pressure on food systems as feeding animals inflates land and nutrient usesource separation of organic matter and its recovery are likely to be critical for the longterm sustainability of the agrifood and wastemanagement systems in an increasingly urban world indeed the transformation of kitchen or green waste and human excreta can provide invaluable resources such as compost fertilizers or energy and eventually remove the need for synthetic fertilizersthis project will develop prospective scenarios for nutrient recovery and assess how far they can bring the agrifood system on the path to circularity using complex networks and systems methods we will convert and analyze existing datasets to generate logistics networks associated to these scenarios these networks will model the fluxes of organic matter between sources habitations processing or storage locations and sinks parcels we will also assess the impact of dietary changes and lowfertilizer or agroecological practices compared to businessasusual situations this will enable us to evaluate the technical feasibility of these recovery scenarios and quantify how much they improve agrifood sustainability and can help local actors tackle their socioecological transition
towards the next generation of excellent young doctoral researchers on mental health by developing an intersectoral transdisciplinary approach

touch towards the next generation of excellent young doctoral researchers on mental health by developing an intersectoral transdisciplinary approach is a new excellent doctoral programme led by the universitat autnoma de barcelona uab for the recruitment and training of 24 doctoral candidates under four major thematic areas in mental health wellbeing research while fulfilling all the principles of open science and maintaining the highest research quality standards the doctoral programme also counts with the participation of 7 reference organisations as implementing partners hosting doctoral fellows research centres research foundations and research organisations linked to prestigious hospitals from the area the programme represents a steppingstone towards the implementation of a longterm collaborative agreement in the frame of the core partnership on mental health one of the communities oriented to strategic challenges the project will act as a key tool to articulate the neccesary capacities from the uab sphere to carry out successful research projects in complex and strategic fields through a collaborative multidisciplinary and innovative approach touch doctoral programme include 60 options to carry out research projects with prestigious supervisors and the availability of worldclass research infrastructures an excellent training programme including practical handsonschools training on research diversity and scientific communication skills and a retreat for personal development among others will provide a holistic approach to the training of fellows through a combination of researchoriented and demanding soft skills in addition the international intersectoral aspects of the programme are boosted by the collaboration with several associated partner organisations including universities private companies social enterprises associations research centres clusters foundations federations for mental health
biologging to inform prevention of seabird bycatch

as the global footprint of fisheries increases to match market demands interactions between seabirds and vessels become more frequent leading to scavenging opportunities for many species but also increase bycatch risk many seabird populations are in rapid decline and bycatch in fishing gears has been identified as a leading causebiopsy is a global project where the candidate will develop skills pertinent to seabird bycatch prevention in new zealand a country with an internationally recognised track record in applied conservation and seabird bycatch management on the return phase these skills will be applied to areas of europe with severe seabird bycatch issues and little to no legislated corrective measures cuttingedge analyses will be developed and applied to seabird biologging data to design effective seabird bycatch prevention measures sbpms biopsy relies on stakeholder engagement for experimental design with engagement skills and implementation focal point of the training programnew zealands open fisheries practices and extensive observer data will be reviewed for sbpms used bycatch rates per hooks set and efficacy of current sbpms then estimated individuals of atrisk seabird species will be tagged with biotelemetry devices that record depth location and acceleration when at sea this will reveal behaviour around vessels in the presenceabsence of sbpms how deep birds dive to scavenge and how this interacts with light availability these behaviours will be placed in the context of current sbpm efficacy and recommendations to improve sbpms communicated to key stakeholdersthe candidate will bring insights gained in new zealand back to europe where observer coverage of fisheries most prone to seabird bycatch is minimal the transferability of using biologging techniques to design sbpms will be tested in a system with fewer sources of observer data and practicable sbpms recommended to policy makers
itank a nuniversal technology to boost the efficacy of car t cell therapies by inducing dual modeofactio

elicera developed a universally compatible technology platform called itank immunotherapies activated with nap for efficient killing to enhance the efficacy of current and under development cart cell therapies by inducing a dual mechanismofaction in the treatment of lymphomas and solid tumours eliceras itank platform can circumvent major challenges of cart cells in the treatment of solid tumours such as antigen heterogenicity local immunosuppression and car tcell exhaustion as such the itank platform has a potential to revolutionise the landscape of the immunooncologyour innovation arms cart cells with nap from hpylori which induces a proinflammatory microenvironment and activates the patients own cd8 killer tcells against the whole repertoire of relevant tumour antigen targets when tumour cells are killed napactivated dendritic cells can take up tumourassociated antigens and prime killer tcells against these antigens overcoming problems for cart therapy
early intensive pastoralism and transhumance in the apennines

classical sources and archaeological data coincide in identifying the existence of transhumant movements in the apennines during the roman period however there is little evidence on how and when it started what was its socioeconomic context and environmental consequences this is hardly surprising since up to now a multidisciplinary approach integrating landscape and archaeological data has never been employed to tackle ancient transhumant practicesearly intensive pastoralism and transhumance in the apennines etransap seeks to investigate the origin of transhumant pastoralist practices using an innovative combination of remote sensing including lidar and multispectral satellite imagery microtopographic survey machine learning movement modelling archaeological excavations and spatial statistical approaches etransap will investigate a central area of the apennines within the territory of the sabines where roman authors identify seasonal flock movements between the mountains and the lower areas in order to identify and date landscape elements related to largescale flock movement by bridging archaeological palaeoenvironmental and historical data etransap aims to provide a holistic understanding of ancient socioeconomic systems and landscape mobility the research is grounded in the premise that understanding the inception and impact of transhumance is key to analyse the origin of mediterranean mountain cultural landscapes this pioneering approach promises to offer new perspectives on the early practices of transhumance and its role in shaping ancient mediterranean societies
exploration of targeting gpr56 and its cancer cell ligand as a novel immune checkpoint inhibition strategy

immune checkpoint inhibitors icis have revolutionized cancer therapy over the last decade in essence icis block the interaction of immunosuppressive receptors and their ligands which attenuate t cell activity and the secretion of proinflammatory cytokines blocking these inhibitory signals results in the release of immunosuppression and promotes antitumor t cell reactivityunpublished data from our research group emerging in collaboration with the biotech company inprother suggests a novel immune checkpoint receptorligand pair consisting of an adhesion g proteincoupled receptor gpcr and a viral proteinwith therapeutic targeting of gpcrs being our main focus we together with our collaboration partner inprother aim to investigate the blockade of the interaction between immune cells expressing the adhesion gpcr and cancer cells expressing the viral protein as novel ici and cancer therapy strategy the exploration of novel immune checkpoints and expanding the repertoire of cancer therapy drugs are paramount for overcoming therapeutic resistance and advancing cancer treatment
ferroptosis inhibitors for neurodegenerative disorders

ferroptosis inhibitors for neurodegenerative disorders neuroferro will focus on the development of potent compounds with improved pharmacokinetic properties including bloodbrain barrier bbb permeability for future application in the treatment of neurodegenerative disorders ferroptosis is nonapoptotic programmed cell death that has been linked to the pathophysiological processes of many diseases including dementia huntingtons disease alzheimers disease parkinsons disease and amyotrophic lateral sclerosis als neurological disorders are one of the most significant causes of disabilityadjusted lifeyears and death worldwide with very limited treatment available although ferroptosis inhibitors developed by augustyns and vanden berghe supervisors are currently best in class compounds they suffer from no or minor bbb permeability therefore the main aim of the project will be the design and synthesis of novel ferroptosis inhibitors with improved pharmacokinetic parameters and high bloodbrain barrier permeability to target ferroptosis in neurodegenerative disorders