Dragon09/odtu_chatbot huggingface dataset:
the influence of extra virgin olive oil phenolic compounds on the inhibition of advanced glycation endproduct formation

olive oil is the main fat source in the mediterranean diet md the healthy properties of extra virgin olive oil evoo are associated with a balanced composition between major and minor compounds among the minor fraction phenolic compounds pcs stand out in terms of their health promoting properties pcs are responsible for the only specific health claim for olive oil recognized by the european food safety authority efsa indicating that pcs in olive oil contribute to the protection of blood lipids against oxidative damage furthermore due to their antioxidant capability pcs are anticipated to exert inhibitory effects on the formation of prooxidant species including advanced glycation endproducts ages which play a pivotal role in oxidative stress and inflammationrelated pathologies phenols4health aims to elucidate the health benefits of foods processed in evoo through the transference of pcs and their potential to inhibit the formation of dietary ages dages a comprehensive investigation will be conducted to assess the transference of evoos pcs into foods of diverse compositions this proposal will also explore the influence of the pcs profile in blocking the formation of ages in foods processed with evoo finally the study will evaluate the profile of ages in serum samples collected from individuals adhering to a md supplemented with evoo and a lowfat diet the methodology required for phenols4health is based on the use of liquid chromatography coupled to tandem mass spectrometry lcmsms for determination of the targeted species the outcomes of this proposal hold the potential to make a profound impact at scientific societal and economic levels by advancing the understanding of evoos healthenhancing properties and its role in inhibiting the formation of dages phenols4health will contribute to food science nutrition chemistry and health fields while fostering economic opportunities within the olive oil industry
toward sustainable foresight capabilities for increased civil security

with the rise of potentially disruptive technologies such as artificial intelligence and virtual reality a particular challenge has emerged for leas and other civil security practitioners tasked with fostering safe societies and protecting european citizens from new forms of criminality they need to preempt technological evolutions turning potential threats into opportunities and anticipate the operational future of policingtechnology foresight is one possible anticipatory process however pure technology watchbased approaches are not helpful for decisionmaking if not embedded in a qualitative assessment of threats and capabilities hence the need to move towards a comprehensive foresight framework which is the rationale behind aheadstanding for toward technological foresight for increased security ahead is a lealed project which will adopt a 360degree approach accounting for megatrends but also contextual elements ie legal ethical societal and economic to design and operationalise a sustainable capabilitybased civil security foresight framework tested through iterative foresight exercises addressing the five destinations of the horizon europe cluster 3 fighting crime and terrorism border management resilient infrastructure increased cybersecurity and disasterresilient society this framework will be tailored to the needs of civil security practitioners to generate evidencebased capability roadmapssuch roadmaps will translate the foresight process outcomes into concrete courses of actions to support decision and policymakers at eu and national levels when deciding on strategies and policy actions in the field of civil security including the programming of security research and innovation investments by enhancing a forwardlooking culture in civil security ahead will contribute to the strategy put forward in the european commissions foresight agenda to embed in a more systematic way strategic foresight into policymaking
conceptualising processes of monumental architectural creation in the eastern mediterranean bronze age

daedalos aims to challenge the predominant metanarrative that uniformly sees monuments as an attribute of centralised hierarchical political economies and topdown power structures a view that exerts a strong influence on our understanding of the organisation of bronze age eastern mediterranean societies in the 2nd mill bce mainland greece western anatolia and the islands of crete cyprus and the cyclades witness a growing architectural elaboration impressive palatial monuments are built which are often interpreted as the seat of rulers exerting centralised control over the population the surmised political power necessary for the mobilisation and management of the human and material resources invested in monumental construction is taken as further evidence for the leading function of these edifices and for the position of their commissioners at the top of hierarchical sociopolitical systems taking into consideration the ability for human groups with no centralised leadership to efficiently manage and control resources daedalos questions the preconceived conflation of monumental architecture and centralised hierarchical power to assess this the project will analyse integration and segmentation patterns in 2nd mill bce monumental building projects of the aegean and cyprus and investigate the organisational centralisation of the societies that managed the labour and material resources invested in construction based on the architectural study of monuments distributed over 35 sites and their examination through new specially devised analytical parameters daedalos will explore the possibility for grassroots bottomup building processes and their impact on architectural creation by doing so the project aims to trigger a paradigm shift in the ways we approach and interpret monumental architecture while producing nuanced and compelling definitions of eastern mediterranean bronze age sociopolitical systems
synergy for healthy longevity

almost all current healthcare systems are based on treating individuals who are already ill relying on periodic interventions when health is compromised and health problems hinder normal functioning this approach is becoming increasingly financially unsustainable and healthcare funding is in a continuous crisis at a global level in the field of health promotion glycans complex oligosaccharides have the highest biomarker potential since they integrate genetic epigenetic and lifestyle factors making them more similar to complex diseases than any other class of molecules researchers in genos pioneered highthroughput glycomics 15 years ago which enabled glycomics to become integrated in multiple large epidemiological and clinical studies through active participation in multiple eufunded projects including 3tr and syscid that are formal requirement for this application researchers in genos analysed over 200000 individual glycomes and identified several potential glycan biomarkers general objective of the synhealth project is to valorise the potential of these research discoveries glycan biomarkers and prepare them for erdf funding and subsequent exploitation in two croatian and one slovenian regions together with the university of maribor this will be achieved with the support of past horizon partners karolinska institute and university of liege innovation capacity and technology uptake will be further supported by the dedicated innovation management and technology transfer partner f6s and glycanage sme partner that actively commercialises glycan biomarkers in the general health and wellness sector adoption of glycan biomarkers for personalised preventive healthcare will be demonstrated in real world setting and supported through a network of partners in the region this will all prepare discoveries from past horizon projects glycan biomarkers for future translation into clinical diagnostic biomarkers through support of erdf funding
integrated glycomics for cancer precision medicine

breast cancer is the most commonly diagnosed cancer in europe and remains the first cause of cancer death in women nearly 92000 deaths in 2020 precision medicine uses datadriven insights to reflect the heterogeneity of patients and improve cancer care by offering actionable oncology treatment options tumour tissue heterogeneity is the leading cause for interpatient variation in treatment response one of the largest sources of tissue heterogeneity arises from posttranslational glycosylation of proteins and aberrant glycosylation is a hallmark of breast and other cancers yet substantial gaps remain in our knowledge of cancer glycans glycomics the comprehensive study of the glycome offers the potential to provide the global glycosylation status glycomap of a patient and shed new light on tumour heterogeneity to guide precision medicine this project aims to address the substantial knowledge gap in breast cancer tumour glycosylation data by developing an integrated glycomics workflow to produce patientspecific glycomaps by including glycosaminoglycan gag omics from intact gags for the first time combined with other glycan analyses will enable the generation of breast cancer glycomaps from resistant and drugsensitive patientderived organoids mini avatars of tumour tissue defining residual tumour tissue following treatment that causes relapse and metastasis the mission and design of the glycomap project is to train the researcher who has a background in gagomics proteoglycan biology and bioinformatics with expanded skills and expertise in noglycomics organoid culture hiresolution 3d imaging and advanced bioinformatics in the context of breast cancer augmenting her future career opportunities as well as establishing unbiased topdown integrated glycomics to support breast cancer analyses diagnostics and the development of novel treatments
advances in food sensory analyses of novel foods

seasoneds overall aim is to improve the knowledge skills and competencies of the research and administrative staff of the faculty of biotechnology and food science fbfs of wroclaw university of environmental and life sciences upwr in the field of sensory evaluation of food and consumer behaviour with particular attention to newly designed innovative processed food products with healthrelated properties the project aims to establish an international network of leading universities and centres in food sensory analysis sdu umh bcc to step up in science and research improving managerial and administrative capacities networking skills and strategies to engage society and citizens as well as public authorities and private businesses and regional and european institutions seasoned will enable fbfs and its partners leading research institutions from spain denmark and united kingdom to codevelop a capacity building programme to share and integrate expertise and skills to access new research avenues and develop new approaches to prepare competitive research applications within the eu and global challenges green deal un sdgs implementing gender balance monitoring open science citizens engagement fair data research principles and monitoring of key performance indicators project will create short to longterm societal scientific and economic impacts ultimately upwrs ambition is to develop and reach the top of the sensory evaluation centres competencies and become the leading centre of excellence in central and eastern europe cee as a result at the end of the project and far beyond the project duration upwr wants to establish a consumer behaviour centre cbc seasoned cbc will be a unique platform dedicated to scientists esrs including the msc and phd students ers other scientists from national and international units business partners and consumers from this part of europe
strengthening coara and enabling systemic reform of research assessment a booster

research assessment plays a crucial role in research systems but current practices prioritize quantitative metrics and publications without recognising the diversity of research outputs or open science practices to address these issues international initiatives have emerged and the eu european research area policy agenda for 20222024 includes a specific action action 3 on reform the assessment system for research researchers and institutions in 2022 the ec science europe and the european university association facilitated the development of the agreement on reforming research assessment which emphasises qualitative evaluation based on peer review and responsible use of quantitative indicators and discourages the use of inappropriate metrics and rankings 423 organisations signatories to agreement decided to constitute the coalition for advancing research assessment coara to make progress on ten commitments within a fiveyear timeframeas an enabler deeply rooted in the coara structure the coara boost project will strengthen the rampup of coara enhancing the operational capacity and providing means to investigate and implement new models for research assessment by amplifying its spectrum of actions and providing the additional capacity to implement a cascade funding programme coara boost will allow to develop a critical mass for reforming research assessment generate gravitas for new members and facilitate the leveraging of additional sources of funding the overarching objective of the coara boost project is to contribute to enabling systemic reform of research assessment following the principles and commitments of the agreement on reforming research assessment coara boost will i strengthen coaras operational capacity ii catalyse knowledge development policy evolution and institutional change in research assessment iii facilitate collection and exchange of information and iv widen the coalitions membership in europe and beyond
mainstreaming pollinator stewardship in view of cascading ecological societal and economic impacts of pollinator decline

butterfly aims to significantly enhance societys capacity to appraise foresee and respond to the threats posed by cascading impacts of pollinator decline to reach that goal it will establish a test system of geographically well spread multiactor communities across sectors for cocreating proactive pollinator restoration solutions and 1 collect integrate manage and share ecological and spatial information on a wide range of known and lesser known pollinators and pollination services provided for wild and cultivated plants across europe and selected overseas territories 2 advance the monetary and nonmonetary valuation of marketed and not marketed direct and indirect ecosystem functions and services provided by pollinators and advance ecosystem accounting 3 comprehensively model and quantify the macroeconomic implications of pollinator decline and countryspecific economic butterfly effects of dependencies on pollinators and assess policy options and scenarios 4 assess how five key biomass supply chains foodmicronutrients pharmaceuticals cosmetics biomaterials biomass energy depend on pollination and cocreate pollinator restoration options that increase resilience of these supply chains 5 devise cocreate test and implement transferable tools interactive atlases and guidelines that enable systematic mainstreaming of proactive pollinator stewardship in vulnerable sectors 6 conceive indicators for human dimensions and assess and exploit the sociocultural capacity of the concepts pollinator stewardship ecoliteracy historical agency and slow hope in reversing pollinator decline it will inform eu policy processes and build strategic alliances for highlevel impact the butterfly network of living labs will accelerate knowledge transfer and uptake of new business models and serve as breeding place for multiactor cocreation of knowledge and sustainable solutions paving the way to pollinator stewardship in all sectors
neurological mechanisms of injury and sleeplike cellular dynamics

focal brain disorders including stroke trauma and epilepsy are the main causes of disability and loss of productivity in the world and carry a cumulative cost in europe of about 500 billion euroyear now physicians diagnose and treat these conditions as if they were caused by local dysfunction due to the pathological process however there is growing evidence that in most neurological and psychiatric disorders clinical symptoms reflect widespread network abnormalities normalization of such network abnormalities through circuitbased stimulation would therefore improve function however this form of therapy is currently limited by numerous factors lack of knowledge about the underlying mechanisms and their behavioural relevance inability to map these abnormalities onto single patients and most importantly a principled understanding of where and how to stimulate the brain to produce functional recoverynemesis from ancient greek as give what is due aims to give an injured brain what is missing ie restore through stimulation normal activity in dysfunctional brain circuitries by synergizing people concepts and technologies nemesis will first characterize the effects of focal injury at multiple spatial and temporal scales from whole brain to local circuits through the combination of observational eg fmri eeg calcium imaging lfps and causal methods eg electromagnetic stimulation optogenetics nemesis will test the hypothesis that disconnected networks lie in a sleeplike state that impairs communication thirdly nemesis will create whole brain models of structurefunction to predict the effect of individual lesions and simulate novel stimulation protocols aimed at reawakening the disconnected brain finally proofofconcept interventions that combine circuitbased stimulation and behavioural training guided by modelling and animal studies will be tested to restore normal activity and so give back what is due
rejuvenation of the intervertebral disc using selfhealing biomimetic extracellular matrix biomaterial tissue adhesives

lower back pain is a global epidemiological and socioeconomic problem this project envisions a future whereby patients with degenerated intervertebral discs are injected with a selfhealing biomimetic adhesive biomaterial which can restore both the biochemical and biomechanical properties to native tissue levels current surgical procedures do not replace herniated tissue from the central nucleus pulposus or repair the annulus fibrosus outer ring of tissue which can lead to accelerated degeneration reherniation and recurrent pain spinal fusion whereby the compromised or degenerated tissue is removed and the vertebral segments are fused together does not restore biomechanical function leading to degeneration of adjacent discs with longterm failure rates as high as 40 my lab has developed a biomimetic injectable hydrogel idisc consisting of the main components collagen and chondroitin sulfate of native disc tissue that can be tailored to match the biochemical and biomechanical properties of native disc tissue in addition the idisc hydrogel demonstrates selfhealing and adhesive properties to facilitate tissue integration and exhibits excellent cell biocompatibility the objective of this proposal is to perform in depth in vitro characterisation wp1 multiaxial biomechanical testing wp2 preclinical evaluation wp3 and marketing and commercialisation evaluation wp4 the development of these injectable biomimetic hydrogel systems may facilitate earlier interventions aimed at halting the degenerative process restore natural biomechanical function enhancing patient accessibility improving quality of life reduce healthcare expenses and lost productivity in the european union the platform technology and knowledge generated through this research are beyond the current stateoftheart and will provide a significant transformative scientific and clinical step change opening new horizons in minimally invasive spine treatment strategies
cellular homeostasis and aging in connective tissue disorders

the increased longevity in developed countries not necessarily goes hand in hand with amelioration of health and quality of life musculoskeletal cardiovascular and neurodegenerative failure are not only hallmarks of the physical and cognitive decline in elderly people but also represent common traits in several earlyonset hereditary connective tissue ct disorders these disorders represent a unique tool for the molecular investigation of such agerelated pathologies due to the specific genetic disturbance of cellular homeostasis the scientific objectives of change are i to investigate ct disorders to identify key pathways responsible for agerelated decline of physiological functions being aware of gender differences ii to learn more about the interdependency of these pathways leading to stereotypic cellular responses including cellular senescence this knowledge will pave the way for developing innovative treatment strategies for common diseases and frailty associated with ageing to this end we will train and establish a network of 10 highlyskilled doctoral candidates dc equipped with scientific expertise transferable skills and societal and environment awareness as a foundation for their future careers to succeed change has built a unique and multidisciplinary network of 7 renowned academic partners and 5 companies including 2 nonacademics as associated partners working together to train 10 young scientists the dc network will address the basic biology of ageing from an interdisciplinary perspective by deeply investigating ct diseases to uncover the pillars of ageing and its multisystemic signatures altogether change will provide an integrative map of cellularextracellular consequences of agerelated changes in cartilage bone muscle and vasculature as consequences to precocious disease exposure
food circuits hidden connections between migrants and societies

most fruit and vegetables required and enjoyed by european and north american societies would not be possible without the planting harvesting and transporting performed by migrant labourers yet the contribution of migrants to crucial food systems is generally hidden in the experience of buying and consuming food in this project i take asparagus from germany oranges from spain and strawberries from california as the vantage points from which to see connections between migrants and societies as well as the ways in which those connections become invisibilized i focus on embodied experiences in food circuits in order to understand the labour of producing and transporting food and the process of consuming and incorporating food into oneself tracing asparagus oranges and strawberries through their circulation i investigate the embodied experiences of migrant farm labourers who are treated simultaneously as essential disposable and sometimes prohibited supply chain workers who are made up increasingly of migrants and work under tight delivery time constraints and consumers who eat with diverse intentions of survival enjoyment identity and ethics i propose a new way of seeing social and embodied connections between migrants and societies through the beauty brutality and necessity of food with foodcircuits i will provide novel contributions on three primary frontsi developing a theory of connections between migrants and societies including on embodied levels by following fruit and vegetables as they circulate from the hands that pick them through the arms that deliver them to the mouths that eat them ii reconceptualizing the ways in which indirect connections between different categories of people are invisibilized through the infrastructures and processes of producing transporting and consuming food iii expanding collaborative methods and ethics in field research across steep social and power hierarchies