Dragon09/odtu_chatbot huggingface dataset:
digital twin politics unlocking the full potential of digital twins for sustainable ocean futures

in the light of time pressure persisting data gaps and challenges to the implementation of global sustainability goals for ocean protection the european commission is currently building a prototype digital twin of the ocean dto the eu dto is part of a larger set of substantial global and national efforts to develop highly accurate digital models of the ocean for better decisionmaking and an emerging hightech knowledge infrastructure that turns various types of ocean data into prediction tools for public and private actors with a stake in the transition towards sustainable ocean futureshowever dtos although needed to advance ocean science and governance are a political issue in themselves firstly dtos run the risk of perpetuating global inequalities because the capacities to develop access and use ocean data information and science are unequally distributed secondly dtos may create an array of legal and political uncertainties regarding data access ownership security and sharing thirdly dtos should be embedded into a set of norms rules and values to prevent abuse and misuse in practice a neglected aspect in the current twin rush twinpolitics will overcome shortcomings in the study of dtos by examining both the sociotechnical making of dtos for national scientific and political purposes and the politics of developing and using dtos in an international setting twinpolitics will reconceptualise digital twins as sociotechnical relations operating under a specific set of institutional political and economic conditions and within a hybrid research data and observation environment twinpolitics will break new ground by developing a methodological approach that combines on the one hand qualitative and quantitative research on the practices policies and politics presiding over digital twins in nationalregional contexts eu usa china with on the other hand the study of dto use during multilateral negotiations
next generation 3d tissue models biohybrid hierarchical organoidsynthetic tissues biohhost comprised of live and artificial cells

biohhost will build biohybrid materials that comprise living artificial cells in dynamic communication such that artificial cells may influence the proliferation differentiation and function of living cells this will be accomplished by producing precision engineered microscale liquid and lipid bilayerbased chemically compartmentalised artificial cells colocalised with live cells this will be done by an interdisciplinary team of biologists engineers mathematicians and entrepreneurs the artificial cells will contain functional metabolisms and the ability to respond to chemical stimuli in the environment to release signaling molecules on demand to regulate the neighboring living cells as found in complex biological tissues these new chemically programmable organoidsynthetic tissues will enable a paradigm shift in both ability to elucidate and control the complexity of physiochemical interactions within 3d tissues and reduce animal use in pharmaceutical rdto achieve these ambitions we have designed an integrated multistage workplan driving towards the following overarching aims aim 1 create 3d tissues where spatial regulation of living cell differentiation is determined by colocated chemically programmable artificial cells aim 2 regulate and maintain such 3d tissues by dynamic communication between live and artificial cells aim 3 develop multilevel multiapproach models of organoidsynthetic tissues behavior these will be applied to target applications aim4 evaluating drug delivery vectors for next generation biological therapeutics and aim5 generation of complex tissues formed of distinct different regions not achievable with current organoid protocols these exemplify our wider ambitions for the biohhost approach including to i understand cell behavior in increasingly realistic 3d tissue models ii elucidate targets for the treatment of disease and iii enable the reduction of animal use in pharmacuetical research
poethics for a new tragic ethics of affection

poethics investigates the role of affection in ethics with a specific focus on two ancient greek poets homer and sophocles both depict moral dilemmas of evil violence and injustice conflicts such as in the stories of achilles or antigone seem unavoidable in the community on the other hand sensible characters like hector ajax or deianeira overwhelmed by bad luck and compelling passions fail to save themselves and their beloved ones the problem vividly expressed in these literary works is how men can find a solution in such hostile situations avoiding violence pain sorrow and death is rationality practical reasoning or observance of principles whether divine or positive ones enough poethics will explore if the subtler ethical message lies in human sensitivity and bonds of affections often symbolized by minor characters whose significance need to be reevaluated bernard williams has endorsed a moral model which takes into account the irrationality of luck and the concreteness of every single persons desires hopes and emotions in ethical judgments and actions on the same path are the works by nussbaum lvinas arendt and following feminist though especially cavarero and butler instead put at the center of moral discourse the concept of shared vulnerability and the role of the other poethics engages with these contemporary strands in ethics but proposes a new approach which puts at the core of moral behaviour the role of personal affections this novel ethical paradigm addresses concrete societal and individuals problems involving complex ethical issues poethics aim will be to spread the knowledge of these ancient texts to specialistic theater and general audience through the fellowship i intend to enhance my expertise in reception and classical studies and to expand my knowledge in moral philosophy at utrecht university my host institution i will be working at the department of philosophy and religious studies
exploiting fundamental insights of m6a methylation on cd8 t cell differentiation and function to boost medicinal t cell products

adoptive t cell therapies have revolutionised cancer treatment in some haematological tumours despite astounding advances patients often relapse because the transferred t cells have low persistence and they lose their effector function against cancer cells the prime challenge for improving t cell therapies is to decipher the mechanisms that define t cell effector function and memory formation the ma6tcell project aims to disentangle this problem by defining how m6a methylation on mrna regulates human cd8 t cell differentiation and function m6a is the most abundant mrna methylation and determines gene expression by regulating mrna metabolism altering as such cell function using the miclip assay i previously mapped genomewide the m6a sites on the mrnas of human cd8 t cells unpublished data i will provide the host with this map revealed that m6a occurs not only at the known drach sequences but also at aurich sequences ares intriguingly the host has uncovered that ares are critical regulators of cytokine production in memory cd8 t cells host expertise my pilot experiments revealed that chemical inhibition of a m6a demethylase in cd8 t cells decreased cytokine production further supporting my hypothesis that m6a methylation controls cd8 t cell differentiation and function to test this hypothesis the m6atcell project will 1 define the regulatory mechanisms of m6a methylation in human cd8 t cell differentiation and effector function and 2 test whether m6a enzyme inhibitors improve the potency of cd8 t cell therapies using chimeric antigen receptor car t cells our findings will yield fundamental insights in t cell biology which can be relevant for multiple adoptive t cell therapies my longterm aim is to transfer my scientific findings from benchtobedside thus i also secured a placement at the european medicines agency and if this proposal is granted i will be trained on the regulatory guidelines of medicinal t cell products
the p2x7 receptor as treatment target for traumatic brain injuryinduced epilepsy

posttraumatic epilepsy pte is one of the most common devastating complications following traumatic brain injury tbi and is particularly prone to drugrefractoriness critically current antiseizure medication remains ineffective in over 30 of patients with no impact on disease progression and frequent adverse side effects increasing evidence suggests inflammation as one of the main contributors to the development of pte atp released during pathological processes in the brain functions as an important extracellular signalling molecule driving inflammatory processes via the activation of the atpgated ionotropic p2x7 receptor p2x7r increasing evidence suggests that targeting of the p2x7r provides potent anticonvulsive effects and possibly diseasemodification during epilepsy whether p2x7r antagonism prevents the development of pte has not been investigated to date my planned research will 1 investigate the diseasemodifying potential of targeting the atpgated p2x7r on tbiinduced epilepsy and associated comorbidities thereby sparing patients from lifelong drug dependency and 2 evaluate the potential of p2x7rbased pet imaging as novel patient stratification tools to identify patients at risk of developing pte for an earlier and more effective treatment start epiprevent brings together a team of experts in purinergic signalling industrial partners developing novel p2x7r antagonists and clinicians specialised in epilepsy this highly interdisciplinary and intersectoral approach will add a significant contribution to the understanding of purinergic signalling during tbi providing novel diagnostic and therapeutic approaches the skills acquired during the research project the excellent training record of the supervisor and host institution and the outstanding resources for learning and development available at rcsi will give me the tools necessary to establish myself as independent scientist
a darker shade of whiteness the italian ethnic press in louisiana and the making of racial awareness in the gulf south 18771945

the stereotypical representations of italians as racially inferior and dangerous for public security saturated the american public discourse at the end of the reconstruction 1877 and tragically materialized in 1891 when 11 italian americans were lynched in new orleans the racial landscape of the crescent city is exemplary of the italian migrants struggle for acceptance across the south and can be fruitfully used as a testbed to study the intertwining of diaspora and race both in the gulf south and nationally through the study of the public discourse emerging from rare and still understudied italianlanguage ethnocultural periodicals published in louisiana and widely distributed outside the state dashow illuminates how the shifting discourses on africans african americans native americans published in the italianlanguage periodical press contributed to manufacture assert and defend the italian race within one of the largest diasporic italian communities in the united states the project will demonstrate how the racialization of southern italians in new orleans and louisiana was the result of the appropriation of stereotypes rooted in the northsouth postrisorgimento divide transposed from italy and rhetorical strategies ascribable to the italian positive school of criminology dashow will study the rhetorical and practical strategies through which the italian communities of louisiana and the gulf south negotiated their racial standing between 1877 which ended the reconstruction thus paving the way for the deprival of african americans voting rights and the formation of an early southern civil right movement 1945 dashow promotes a comprehensive framing of the italian diasporic presence in the racialized geographical social and cultural context of the gulf south and aims to preserve and popularize perishable documents for the study of italian emigration through the digitization of primary sources and the production of digital learning tools
triple junction solar modules based on perovskites and silicon for high performance lowcost and small environmental footprint

the triumph project aims to initiate the development of a future pv cell technology node based on an advanced triple junction cell concept that is widely considered to be the next technology node to come after tandems presently there is considerable amount of attention and research and development rd activities devoted to pksi tandems and already promising cell efficiencies reliability and outdoor performance results have been obtained the highest efficiency reported for a 2terminal 2t pksi tandem is 298 which has already gone past the auger limit of si therefore in triumph we plan to venture a step further than tandems by targeting triple junction devices that can add the extra oomph hence the name triumph needed to reach efficiencies even 33 these 2t triple junction devices will be based on perovskites for the middle and top cells and silicon for the bottom cell and will build on the knowledge garnered in the field of pksi tandems additionally costeffective processing techniques that are industrially viable will be selected for scaleup developments with minimal upscaling performance loss and degradation during reliability testing and outdoor monitoring as we enter the terawatt tw era of pv deployment using earthabundant materials and enforcing circularity become necessities towards this objective we not only explore options that reduce critical raw materials crm such as silver ag and indium in in the triple junction devices but also apply design for recycling principles to the triple junction modules the consortium consists of 14 complementary partners from both research institutions and industry each bringing their best forte to the table which will help to establish the pathway and the value chain for future multijunction modules in this way triumph would help the european union eu to maintain its technological leadership in the pv domain for the future generation of pv technologies
revealing 3d atomic structure and chemistry in scalebridging volumes via 5d hyperspectral electron tomography

electron microscopy is essential to understanding structurepropertyfunction relationships in modern materials engineering condensed matter physics chemistry and structural biology yet due to complicated scattering physics todays electron microscopes can only image tiny volumes with 3d atomic resolution within this project i will turn the tables by utilizing and inverting the scattering physics to image scalebridging volumes with atomic detail and chemical superresolution combining compressive dataacquisition protocols stateoftheart electron optics and detectors and codesigned computational imaging algorithms will make this possible i will use tomographic experiments and computationally invert the multiple scattering from multidimensional measurements in scanning transmission electron microscopy to determine 3d atomic structure and chemistry in technologically valuable volumes this has not been realized yet due to significant bottlenecks in the computational complexity of the underlying algorithms and a lack of experimental automation which i plan to overcome in this projectthe project is divided into three main objectives1 imaging 3d atomic structure in large volumes 2 visualizing atomic chemistry in scalebridging volumes3 profiling 3d atomic structure chemistry and dynamics in controlled insitu experiments across scales these methods will be applied to essential materials including examining single hydrogen atoms at grain boundaries in structural metals and studying concealed extensive interfaces in modern semiconductor materials in the final phase i will record atomistic movies of material fracture in tungsten and alloys fracture is one of the most critical failure modes of structural materials with catastrophic consequences the details of crack nucleation and propagation through the breaking of bonds are still largely unexplored and will be measured directly and compared with largescale atomistic simulations
polymer based electrooptic pcb motherboard integration with si3n4 chiplets inp components and electronic ics enabling affordable photonic modules for thz sensing and quantum computing applications

despite the significant advances that photonic integrated circuits pics offer in terms of miniaturization power consumption and functionalities they run into scalability and cost issues related to the fabrication yield the increased integration and packaging complexity the lack of wafer scale compatible processes and the lack of integration and packaging standards furthermore so far photonic packaging considered the subghz electrical connections to the pics as a separate and second priority issue until the number of electrical ios of the pics was too large to ignore polynices aims to address these challenges with the development of a novel general purpose photonic integration technology compatible with wafer scale processes that will reduce the production costs of photonic modules by at least 10x polynices will develop for the first time a polymer based electrooptic pcb eopcb motherboard that will host si3n4 chiplets inp components and microoptical elements polynices invests in si3n4 platform with pzt actuators to realize complex structures in only 1x1 cm2 chiplets with ultralow power consumption the chiplets grid array electrical pads and the use of flipchip integration on vertical alignment stops will allow optical alignment and electrical connection in one step the standard size and interfaces of the chiplets as well as the electronic ic copackaging on the same eopcb provides excellent scalability and customization and significantly simplifies packaging dielectric rod thz antennas will be integrated on the eopcb taking advantage of its good hf properties using the above novel concepts and building blocks polynices will develop a fully integrated optoelectronic fmcw thz spectrometer with thz antenna array and beam steering abilities for quality control in plastics a 16x16 quantum processor with integrated 780 nm light source and nonlinear crystals and a 24x24 quantum processor with integrated squeezed light state source
a revolutionary technology platform for providing lifesaving treatment for endstage heart failure patients

over 500k patients in the eu and us suffer from endstage heart failure hf with a life expectancy of 1 year in 38 of cases the prevalence of hf has increased recently mainly due to improved survival after heart attacks such patients require mechanical support of their hearts available treatment options are heart transplantation htx and ventricular assist device vad today 3 of these patients are treated due to donor heart shortages and restrictive employment of vads vads can cause severe complications such as bleeding and strokes and typically only support one side of the heart rebeat is a revolutionary technology to mechanically support both sides of the heart does not directly contact blood and can be easily implanted 40 minutes it presents virtually no contraindications for the patient population described rebeat offers high cost effectiveness at 50 of the cost of heart transplantations and vads adjucor expects revenues of 69m by 2027 with rebeat
nanofluidics for labelfree detection of exosomes and protein aggregates in neurodegenerative disease research

microfluidics have become a powerful tool in biotechnology and life sciences whereas the nanofluidic regime remains widely unused in industry and the clinical environment especially protein misfolding diseases such as alzheimers parkinsons and huntingtons disease recently experience a growing demand for singlemolecule detection capabilities as the assembly process of a single corrupted protein is correlated with its aggregation propensity and spread of the disease conventional microfluidic methods to study relevant biomarkers and aggregates involve fluorescent labelling which alters the samples properties and puts additional constraints on experimental design we therefore seek for methods to study macromolecules in particular exosomes oligomers in a labelfree manner in solution without chemically altering their propertiesto overcome this limitation the project combines innovative nanofluidic technology with cuttingedge labelfree microscopy techniques first hybrid 2photon lithography is used for the scalable costeffective nanofabrication of nanofluidic polymer chips secondly these chips are then employed for the detection and sizing of exosomes 100 nm and alphasynuclein protein aggregates 12 nm in solution using labelfree imaging methods eg qpm and duvmthe approach presented here allows protein misfolding researchers to study oligomerization more efficiently by running orders of magnitude more experiments with same already limited material and greatly increases availability of nanofluidic chips for protein metrology in existing biological laboratories new expertise excellence management skills and scientific training acquired during the action prepare the researcher for a role as independent dementia research group leader in europe using stateoftheart nanotechnology to establish nanofluidic singlemolecule detection of protein aggregates and macromolecules as new golden golden standard in life sciences research
green h2 and circular biocoal from biowaste for costcompetitive sustainable steel

the achievement of the netzero emissions target established by the european commission is huge challenge which could not be achieved without rethinking the conventional route materials and energy chains h2steel project proposes an innovative disruptive solution to convert wet waste streams into green hydrogen carbon and critical raw materials the proposed innovative solution aims at supporting the green transition of one of the most hardtoabate industrial sector metallurgy in particular h2steel combines the conversion of biowaste and bioch4 through innovative catalyzed pyrolysis with chemical leaching to fully convert biowastes into green hydrogen green carbon biocoal and recovery of critical inorganic raw materials biomethane pyrolysis is carried out in a brand new adhoc designed and proofofconcept reactor on a bed of biocoal made from precarbonized biowastes ie on a very cheap fully carbonbased catalyst very resistant to temperature and contaminants this will enhance the efficiency of the methane cracking step to generate green hydrogen as new solid carbon from methane cracking is generated on the biocoal surface thus reducing the performance of the catalyst new biocoalcatalyst is inserted in the reactor while the spent biocoal is removed the continuous renewal of the catalyst is feasible thanks to its low cost and to the market value of the spent catalyst this material fully biocarbon based is then used in steelmaking as a substitute of metallurgical fossil coke generating a net ghg reduction eu ets emission trading scheme compliant the regeneration of the spent catalyst thus becomes unnecessary as the biocoal is used in a downstream process avoiding the release of co2 in atmosphere as it happens in the smr process or in most of the catalysts regeneration steps