Dragon09/odtu_chatbot huggingface dataset:
copernicus responding to eu cities mission

the recently concluded h2020 project cure prepared the ground for exploitation of copernicus core services in urban planning achieving climate neutrality requires a city that has joint the eu mission on climateneutral and smart cities the cities mission to reduce the greenhouse gases ghg emissions from all sectors within the citys boundary to net zero by 2030 including emissions within the city boundary from combustion of fossil fuels in buildings and facilities combustion of fossil fuels for all vehicles and transport and changes in land use agriculture forestry and other land uses all the above are considered as scope 1 ghg emissions direct emissions and the copernicus land monitoring service clms based on the cure method for co2 emissions monitoring holds promise in aiding cities to achieve the ambitious goals of the mission by assisting in monitoring the efficiency of efforts to trace the advancement towards climate neutrality the proposed project clmscities copernicus responding to eu cities mission aims to improve clms with new elements and products capable of being integrated into land planning decisions with regard to climate change mitigation at local scale clmscities will contribute to clms evolution as it is expected to lead to more evidencebased urban planning activities related to climate change mitigation resulting in improved ghg emissions inventory methods and outputs to support cities to meet the missions ambitious objectives it will focus on the ten cities of the mission that were recently 2023 labelled providing the missions community with spatially disaggregated environmental intelligence at a local scale and a proofofconcept that urban planning and management strategies enhancing the ghg inventories can be supported by clms clmscities method will be modular and scalable delivering consistent products across the cities of the mission and developing synergies between clms and thirdparty data sources
deciphering females sex hormones microbiota interactions during a menstrual cycle for an efficient personalized medicine in cardiometabolic disorders

cardiometabolic disorders cmd a group of conditions that include cardiovascular diseases type 2 diabetes and metabolic syndrome are characterised by dysfunction of glycaemic andor lipid metabolism clinical manifestations severity and progression are different between sexes the underlying mechanisms of which are largely unknown the poorer prognosis in women globally calls for an urgent need for better womens tailored prevention and treatment strategies still for an efficient personalised strategy femalespecific mechanisms have to be identified the semicycle project will systematically investigate females sex hormonesmicrobiota interactions to unravel femalespecific microbiota features regulating glycaemic and lipid metabolism in women during homeostasis and diseases findings of this research project will pinpoint key mechanisms useful to improve current prevention and diagnostic tools as well as therapeutic options of cmd semicycle will follow up 300 healthy women during one menstrual cycle and longitudinal crossomics data five layers of information from host genome gut microbiome gut metabolome vaginal microbiome plasma proteome will be generated analysed and integrated with female sex hormones variations lifestyle and diet glycaemic and lipid phenotypes using stateoftheart methodologies and computational approaches subsequently mechanisms identified during homeostasis will be investigated for association with cmd onset and progression using already existing cohorts totalling more than 10000 samples this research is based on my expertise and that of my research group in generating and analysing omics data in large data sets findings will reveal previously unknown microbiota regulators of cmd in women thus offering alternative routes for prevention diagnosis and treatments in women a necessary step for an efficient personalised medicine
mining food for nutraceuticals for beneficial microbiome modulation

the human gut microbiome is recognized as an essential element in human health and disruption of the homeostasis between the host and gut microbiome has been associated with the development of various diseases diet plays a major role in modulating the gut microbiome but understanding the exact relationship and its effect on health remains a key challenge in microbiome research nutrome aims to develop nutraceuticals food components with health benefits based on key dietary components of the mediterranean diet that are capable of modulating imbalances or dysbiosis on the human gut microbiome of two relevant population groups the elderly and people with irritable bowel syndrome understanding how key dietary components and gut microbiome interact in the context of dysbiosis will require insight of the taxonomic and functional composition and relevant ecological dynamics of the microbiome by cuttingedge microbiome manipulations and multiomics approach joint analyses of metagenomics metabolomics and metaproteomics data together with measures of mechanistic experiments in in vitro cells and an in vivo germfree mice model will allow me to provide a framework for the understanding of the potential molecular mechanisms behind these modulations other original aspects of nutrome will be the evaluation of not only the impact of pure compounds but also the development of new forms of presenting them by encapsulation andor immobilisation to guarantee that they reach the target site and microbial population of interest in the gut collectively this will allow to design nutraceuticals for dietary intervention in the form of enriched foods or dietary supplements nutrome provides an exceptional opportunity to the researcher to gain stateoftheart expertise in microbiomics along with other relevant research and transferable skills to strengthen her competitiveness for becoming an independent researcher
next generation imaging for realtime dose verification enabling adaptive proton therapy

the novo project will address a fundamental issue in proton radiotherapy pt of cancer namely the lack of realtime dose verification rdv that significantly limits the potential of pt due to uncertainties in the precise delivery of the prescribed dose in the novo project we will develop the first proofofconcept of an rdv technology adaptable to any pt treatment and bring the concept to trl 4 by also considering integration into the pt clinical workflow the rdv technology will be pivotal for enabling the next generation of adaptive pt therapy ie doseguided realtime adaptive therapy realtime measurement of the dose to targeted and nontargeted tissues will be the key to truly empower patientcentered personalized cancer treatment important to improve curation and qualityoflife posttreatment as a highriskhighgain project novo aims at a firstofitskind rdv technology through the unique synergy between 1 cuttingedge inexpensive organic scintillator technology that can detect secondary radiation during treatment for noninvasive measurements 2 novel and fast image reconstruction artificial intelligence aiaccelerated models and aienhanced image reconstruction to allow simultaneous detection of multiple radiation species and tissue compositional analysis 3 tumortracking and imaging of tissue radiosensitivity based on oxygen levels 4 intelligent automation of decisionmaking schemes for realtime doseguided adaptive therapy the project will essentially open a new era in pt that enables curing more cancer patients and reducing toxicity from treatment the novo consortium covers the entire value chain of rdv development technology providers theory and modelling technology integration and pt clinics and optimally engages nuclear medical and highenergy physicists chemists mathematicians computer scientists oncologists biologists as well as european pt centers
molecular quantum heat engines

heat engines are an integral part of our daily lives they power cars or produce electricity by converting heat into work increasing their efficiency is very difficult and only marginal improvements have been achieved over the last decades thus to reach the ambitious climate goals it is necessary to go beyond conventional technologies atomsized systems where quantum mechanical effects come into play could enable this theory predicts that their efficiency can be boosted beyond the classical limits imposed by thermodynamics however so far this has not been tested in practice due to a lack of suitable model systemsi propose to build a molecular heat engine of only a few atoms in size with such high control over its structure and properties that these predictions can finally be tested the engines quantum properties will be robust at experimentally accessible temperatures its coupling to the environment will be controllable and electrical transport through it will be quantum coherent i seek to exploit the full gamut of their physical properties to boost efficiency including spin entropy and vibrational coupling practically i will 1 implement a scanning probe setup into a dilution refrigerator 2 fabricate singlemolecule junctions with microheaters and ultrasensitive superconducting thermometers and 3 perform and interpret caloric experiments on single molecules at unprecedented precisionthe results will teach us about the fundamental properties of atomscale quantum systems and heat flowing through single molecules it will inspire new ways to increase the performance of thermoelectric applications such as waste heat harvesters nanoscale spotcooling devices or even thermal rectifiers and transistorsi am one of the forerunners in molecular thermoelectrics with extensive handson experience in material sciences nanotechnology and mesoscopic physics this multidisciplinary background is needed to make this ambitious project a success
transcription factor gene therapy for bradyarrhythmias

pacingcure has developed bradytx01 a novel gene therapy medicinal product gtmp to cure lifethreatening cardiac pacing dysfunctions by reprogramming cardiomyocytes into pacemaker cells bradytx01 is based on a novel method to optimally control transcription factor overexpression through adenoassociated virus aav mediated gene transfer the biological pacemaker that is created 1 improves cardiac function 2 responds to metabolic demand 3 can be delivered using minimally invasive techniques and 4 potentially lasts a lifetimein the traction project pacingcure together with aumc will further optimize aavmediated transcription vector gene therapy for pacemaker applications validating the novel aav vector technology in mice pigs and nonhuman primates subsequently a largescale manufacturing process will be designed to release the materials that will be used for validating and demonstrating longterm safety and efficacy in porcine studies thereby establishing preclinical proofofconcept of bradytx01in parallel we will validate and optimize the technologyproductmarket fit of bradytx01 and the evolving value propositions will be tested and optimized with relevant stakeholders we will define the optimal regulatory strategies perform health technology assessments and develop the optimal business strategy thereby setting the stage for effective clinical and commercial development of bradytx01within the traction project we will take the next steps in our development while also establishing the optimal strategy for our trajectory towards the clinical stage and commercialization of bradytx01 the traction project will thus facilitate the complete transition of pacingcure into a fully operational company with an attractive and investmentready business proposition
training future big data experts for europe

bigdata management through highperformance computing is nowadays considered as the richness of the new knowledge economy providing unprecedented opportunities in several ri and applicative domains from climate change to health from mobility to cultural heritage from digital change in production systems to new materials and financial analysis in italy 70 of the national computing and storage capacity is set in the emiliaromagna region making it an authentic data valley while supercomputing infrastructures are a prerequisite for european competitiveness datadriven ri needs qualified experts in datascience and bigdata application in relevant societalindustrial domains in this context the university of bologna in partnership with the other 5 universities located in the region with the support of the regional authority and involving the relevant stakeholders is proposing futuredata4eu to train the datascience experts of tomorrow through an interdisciplinary international and crosssectoral approach futuredata4eu builds on existing phd courses will offer a pioneering combination of training in research and transversal skills in the multi and transdisciplinary field of bigdata through the enabling technologies and the thematic areas representing the horizon europe clusters 1 health 2 culture creativity and inclusive society 3 civil security for society 4 digital industry and space 5 climate energy and mobility 6 food bioeconomy natural resources agriculture and environment
promoting innovation excellence in transformation of coal regions to climateneutral thriving economies

energy efficiency renewable energy sources energy storagebatteries hydrogen efficient buildings climate neutrality reduction of greenhouse gas emissions and decarbonization of industries coal regions are in the heart of european policies for the new programming period ie green deal eu strategic energy technology plan twin industrial transition etc many financial instruments have been setup to support these objectives that have a common denominator in sustainable energy eu alliances across the value chains ie eba ipceis ie descarbonization hydrogen batteries and research policy platforms ie coal regions in transition are dedicated to facilitate the advancement of ri in the field through the collective effort of eu members and enable the transformation of eu regions to climate neutral thriving economies this context finds a lot of countries striving to comply especially challenging those that traditionally have economies heavily dependent on fossil fuel mining and exploitation a major shift has to be done in a short amount of time putting at risk the balances in the local economies and making yearslong expertise and wellestablished skills become obsolete coalition intends to strengthen the regional innovation ecosystems in coaldepended areas through the creation of regional excellence hubs and the definition of a joint strategic agenda for sustainable energy so as to facilitate their transition in a just and inclusive way the regions have been carefully selected western macedonia gr centru ro southeastern bg among the under transition eu states that are also characterized as widening in an attempt to maximize the longterm impact of the joint ri strategy that will be developed within the project as those territories are about to amass large amounts of funding and coalition aims to create multiplier effects in the given investments by attracting and mobilizing external investments
investigating mammalian evolution using millionyear genomic transects

the field of ancient dna has made major contributions to evolutionary biology and palaeontology in recent years due to its power to reveal novel information about prehistory however even though many of the evolutionary processes that shaped the presentday biota have taken place over hundreds of thousands of years nearly all ancient dna studies to date have focused on biological changes during the last 50000 years i here propose a groundbreaking project that aims to study evolution on a millionyear time scale we will develop and apply novel palaeogenomic methods to extend the current limits of dna recovery which will allow us to address scientific questions previously thought to be beyond the realm of ancient dna research more specifically we aim to sequence one hundred ancient genomes recovered from early and middle pleistocene remains of multiple holarctic mammalian species this will enable us to examine macroevolutionary changes across speciation events and key periods of pleistocene climate change more specifically we will investigate several fundamental questions on how species originate the importance of interspecific introgression the timing and rate of adaptive evolution and the demographic consequences of past environmental change my research group has a trackrecord at the cuttingedge of wildlife palaeogenomics and recently led the study that extended the limit of ancient dna recovery to beyond one million years based at the newly established centre for palaeogenetics in stockholm the project will extend beyond the current state of the art and will set a new paradigm for palaeogenomic research the resulting data will provide an unparalleled resource for researchers studying longterm evolutionary dynamics and environmental changes at a global scale
the transmission and transformation of texts in the tarim basin a corpus approach

the transmission and transformation of texts in the tarim basin a corpus approach project 4tb is designed to contribute to the study of three prominent languages of the preislamic tarim basin in todays xinjiang uygur autonomous region in the peoples republic of china tocharian a old uyghur and sanskrit the innovation part of this contribution assumes creating a comprehensive parallel text corpus of buddhist texts in the said languages an openaccess digital tool for linguistic and philological study the research part assumes analyzing details and searching for patterns of transmission and transformation of those buddhist texts from sanskrit to tocharian a from tocharian a to old uyghur this is going to be achieved by answering the following research questions 1 what are the linguistic patterns of transmission and transformation of the discussed texts 2 how were the discussed texts transmitted and transformed from the philological point of viewthe results of my action will substantially facilitate crosslinguistic studies for scholars of three language groups also they will have an interdisciplinary impact bringing a large amount of textual information to nonlinguist researchers eg scholars of buddhism and historians moreover my action has a potential for further research as it can later include other adjacent languages the host institution will be university of vienna my supervisor will be hannes fellner one of the key developers of the cetom project the tocharian a and b text corpus and the lead of the tarim brahmi project his experience in digital humanities and the tocharian studies will be extremely helpful for my research
slaves of religion paternalism and resistance brazil

slavesreligion is an interdisciplinary proposal aimed at understanding the process of implementation exploitation and perpetuation of slavery in the properties of the lusobrazilian benedictine congregation between 1750 and 1871 highlighting issues related to gender race and slavery in the atlantic world it also intends to analyse the resistance strategies built by enslaved men and women against the disciplinary and moralising measures of the order of saint benedict the project aims to demonstrate that this congregation played an important role in the construction of modern slavery transforming it into one of the richest and most powerful slave orders in brazil the benedictines built efficient and durable strategies for managing slaves through measures designed to control female behaviour access to freedom and reproduction despite the importance of this congregation in the construction of modern slavery few historians have analysed its peculiarities there are indications that this religious order encouraged its slaves to own slaves moreover there is also evidence that they encouraged enslaved women to reproduce in exchange for benefits especially freedom besides there are suggestions that they allowed slaves to accumulate patrimony and pass it on by inheritance to their heirs the results of this research will be disseminated through various means such as social media digital platforms and seminars among others when concluded the research will render three scientific articles on the peculiar slave management of the benedictines and the resistance strategies of the enslaved population with a special focus on slave women
method for integrated alloptical biological analysis at scale

the advent of lightemitting sensors and lightdriven actuators has profoundly transformed the fields of biology and medical science over the past three decades these innovations enable the manipulation and monitoring of various physiological processes using light with remarkable precision in both time and space applications include the study of signaling and cell trafficking in healthy and malignant tissues the unraveling of causal relationships within neural networks or the assessing the effects of pharmaceutical compounds to fully harness the potential of these socalled optogenetic technologies there is a pressing need to create integrated optical systems offering both 3d imaging and precise lighttargeting of specific regions at scale within the framework of the erc we have successfully engineered a unique system designed for the optogenetic probing of small vertebrate brains zebrafish larvae at cellular resolution our proposal expands upon this earlier achievement by evolving it into a versatile alloptical platform tailored for biologists and biomedical laboratories this platform will seamlessly integrate cuttingedge optical systems with automated data analysis through artificial intelligence ai techniques anticipating a vast array of applications we envision that this platform will prove invaluable eg in the realms of neuroscience developmental biology and cancer research its multifaceted capabilities will empower researchers to unlock new insights and accelerate advancements in these critical scientific domains
preclinical study continued technology development health economic analysis for navari surgical ab

cancer is one of our times most threatening diseases killing more than 10 million people each year approximately 60 of all cancer patients will need some type of surgery where minimal invasive surgery is commonly known as the best type of procedure from the patients perspective where recovery time and infections can be kept to a minimumdespite proven benefits from a patients perspective the utilization of minimal invasive cancer surgery remains relatively low limited visualization with large challenges in identifying the cancer tumors position are a strongly contributing factor the limited view from the surgical camera makes it challenging for the surgeon to navigate along the surgery procedure not to mention removing the tumor with precise marginsnavari aims to revolutionize todays minimal invasive cancer surgery by developing a technology increasing the visualization aspect during this type of procedure by utilizing augmented reality navaris innovation can present the surgeon with an arprojection showing the cancer tumor and its exact position inside the organ the projection of the cancer tumor is shown as an integrated part of the video feed from the surgical camera enabling livestreamed navigation assistance along the full procedure in short terms our innovation enables surgeons to locate and remove the tumor in the safest and most precise way possible in this project we aim to design and perform a preclinical study realizing our next value enhancing milestone giving us the validation needed for the innovation to enter future clinical studies with the data given from the preclinical study the business model could be validated further where a health economic analysis could be performed measuring the social sustainability impact of our innovation the outcomes from the study would enable further product optimization from a technical perspective as well as strengthening our communication towards investors