Dragon09/odtu_chatbot huggingface dataset:
wellbeing inclusion sustainability and the economy

wise horizons will inform and accelerate the transition to a new economic paradigm with wellbeing inclusion and sustainability at its core the project will create a stateoftheart theoretical framework which synthesises the current postgrowth initiatives through a novel and open access wise accounting framework the framework will define core terms and link to beyondgdp metrics satellite accounts policy strategies and the current generation of economic and integrated models it will link to european policy strategies such as the netzero targets the circular economy transition and sustainable competitiveness with partners in africa the us and china it will also globally assess the current and new economic paradigms from the perspective of sustainable developments goalsany transition will result in tradeoffs and synergies between different elements of a new economy such as wellbeing inclusion and sustainability these will be empirically analysed and used to inform policy and society about the choices that will shape the future up to 2050 the historical empirical analyses will use the wise database and thematicintegrated models that address the core questions and policies of the postgrowth society will be created by leading expertsinstitutes in the field of beyondgdp inequality sustainability and postgrowth economicsto maximise the impact of the project the wise stakeholder platform which is a network of networks will be created and the groups involved in the wise platform will be engaged in communication dissemination and exploitation the empirical research involved in this project will be done in a novel cocreative approach involving stakeholders in 5 cocreation labsworkshops special attention is given to individuals that are negatively affected by the transformation an ambitious communication strategy will facilitate a new public debate away from the standard economic paradigm and towards a new paradigm fit for the future
vulcan matter powered from within

vulcan the roman god of blacksmithing was revered in europe since the iron age 1200500 bc for a powerful skill controlling the macroscopic properties of metals strength ductility toughness to this day thermal treatments such as annealing cycles of high temperatures alternated with slow cooling remain an essential tool of material science however vulcans traditional powers forge monolithic static and passive materials and are laughably blunt instruments when compared to living materials which dynamically reconfigure repair and rebuild themselves living systems provide proofofconcepts for what can be achieved assembling functional materials from elementary blocks that consume fuel vulcan matter powered from within takes forging into the modern age injecting energy directly through active agents present in the materials it is experimentdriven and bottomup establishing novel experimental strategies to fabricate materials powered from within with phases and structures that cannot be achieved via thermal treatments and present nonconventional mechanical and rheological properties selfhealing odd viscosities the proposal notably aims to control the phase diagram of matter with spatiotemporal modulation of activity of the bath we will devise an active bath of swimming bacteria to assemble macroscopic and 3d colloidal crystals and gels objective 1 with structures and at scales that cannot be achieved thermally in parallel we will devise exotic condensed phases of matter 2d liquids of spinners and networks of active beams objective 2 made from large numbers of autonomous micromachines built from lightactivated colloids this is uncharted territory and an ambitious and highrisk goal fueling vulcans lasting impact tearing down the boundary between active matter and materials science and opening the path to a new class of materials powered from within with applications in bioengineering and photonics
innovative digital twins for advanced combustion technologies

significant adoption of renewable sources will be witnessed in future years to meet the longterm objective of co2 neutrality and mitigate the effects of global warming while electrification will play a key role in the transition to a sustainable energy system combustion processes will remain part of the picture requiring sustainable combustion technologies and renewable synthetic fuels the design and development of novel combustion technologies in power and heat generation transportation and manufacturing processes require developing a digital combustion infrastructure that promises to bring down the needed rd investments for meeting the tightening environmental regulations however predicting combustion processes is a complex and challenging task and the tools available today fall very short of what is needed for new design and optimisation we made an innovation that formed a digital twin combining theory experiments simulations and machine learning into one unique combination with our approach we can predict complex multiphysics systems that can be used for designing combustionbased energy generation applications for growing markets our approach is expected to impact significantly new combustion systems while reducing the resources and time for designing such fuelflexible nonpolluting and energyefficient systems this is expected to have vast commercialisation potential in the industries 1 designing environmentally friendly energy systems and 2 supplying digital tools for the design processes
deciphering cancer heterogeneity and drug resistance using singleclone genomic and epigenomic landscapes

to comprehend the characteristics phylogenetic relationships and drug resistance of tumor subclones measurements must be performed at singlecell or singleclone resolution aims 1 and 2 aim to create costeffective and reliable singlecell drop technologies for capturing fulllength rna scflrnaseq and enhancers at the dna level chromopen it is noteworthy that scflrnaseq also captures noncoding and nonpolyadenylated rnas besides coding mrna chromopen also offers better capturing of functional enhancers and higher sensitivity compared to the conventional technology the ultimate goal of aim 3 is to create the first technology that can capture both fulllength rna and enhancers from the same cell multiomics to increase sensitivity and coverage multiomics will be combined with a 3dculturing system 3dclone that facilitates growth of primary cancer cells into small clones the singleclone based multiomics maps will increase the discovery rate of genetic somatic diversity including noncoding regions reveal connections between gene expression and mutated loci and display a wider range of functional state associations between cells in aim 4 using our innovative mapping technologies we will investigate two brain tumors nonsmall cell lung cancer that has spread to the brain and glioblastoma primary cells both of these cancers have limited treatment options and poor outcomes due to drug resistance based on temporal drug treatment experiments and advanced mapping technologies this data will improve our understanding of somatic driver mutations and cellular diversity in the context of resistance and ultimately lead to the identification of new therapeutic targets
set plan conference 2022

this is a proposal to host set plan conference 2022 in the czech republic during the czech presidency of the eu the conference will take place in prague on 9 10 november 2022 the programme is dived into several thematic sessions dedicated to eg lowcarbon sources industry buildings hydrogen ccs etc there will be a highlevel panel where we expect the attendance of commissioners simson and gabriel minister of industry and trade will also be present the first day will be closed by an informal dinner the conference should promote research and innovation in the eu and enable discussions among different researchers a result should be recommendations on the future orientation of the eu research and innovation programmes
first in class oligo therapy for myotonic dystrophy type 1 dm1

myotonic dystrophy type 1 dm1 is a clinically and genetically heterogeneous disorder with more than 1 million diagnosed patients worldwide making it the most common adult muscular dystrophy available treatments only relief symptoms given this need we offer atx01 a first in class mirna therapy that inhibits mir23b without changing the dna which rescues dm1 pathogenic missplicing we have demonstrated improved target engagement effects in skeletal and respiratory muscle in invitro and invivo studies granting us an fda preind approval and orphan drug designation our approach antimirs conjugated to fatty acids constitutes the entry platform which guarantees efficient drug delivery to target muscular and extramuscular tissue at low doses this patented technology will be validated through a phase iiia clinical trial and chronic preclinical studies to then be extended to applications as other myotonic dystrophies fuchs dystrophy cachexia among other opportunities
spectroscopyiku manipulating and characterizing molecular architectures from isolated molecules to molecular crystals

spectroscopyiku aims to strengthen molecular physics chemistry and materials sciences at istanbul kultur university iku by establishing a strong internationally competitive research team dedicated to molecular spectroscopy at the iku faculty of sciences and letters the team will be led by prof rui fausto era chair holder a worldleading scientist in the field a new research infrastructure dedicated to spectroscopy will be created supporting the era chair team and serving as a spectroscopy platform for other iku research groups additionally it will provide spectroscopy services to external users from both academy and industry the erachair research team will engage in training young researchers and postgraduate students contribute to the academic activities of iku on spectroscopy and participate actively in outreaching actions all activities will follow the principle of free circulation of knowledge and expertise aligning with era priorities research will focus on two main areas sharing the need for precise molecular structure manipulation and characterization i structure and reactivity of atmospheric and astrophysically relevant molecules and ii polymorphism in molecular crystals and cocrystals the first subject centers on the laboratory study of isolated molecules and small aggregates addressing fundamental chemistry and physics in earths atmosphere and space through exploration of new avenues of chemical reactivity and their underneath physical processes such as reactions resulting from vibrational excitation of molecules or taking place via quantum mechanical tunneling two subjects the erachair holder has been pioneering the second main subject is a hot topic in materials sciences and one of the most crucial subjects for pharmaceutical industry at the moment new approaches for polymorphs screening will be implemented based on the development of novel versatile techniques for molecular crystalscocrystals generation
ngi commons open source and internet commons for europes digital sovereignty

the ngi commons project aims to align and integrate next generation internet ngi efforts within the broader european digital and internet commons dcic landscape addressing key governance issues such as digital sovereignty cybersecurity and personal data selfdetermination to achieve the ec call objectives the projects consortium combines expertise in digitalinternet commons open source the european digital policy landscape with a deep understanding of the overall ngi initiativedigital commons including open source software hardware design standards and data are essential to support sovereignty trust and democratic values in society their economic and geopolitical importance has been recognized in the eus digital decade strategy to unlock the full potential of digital commons efforts must be made to overcome fragmentation and bridge the gap between bottomup movements and topdown regulatory efforts a role that the ngi commons project can effectively playthe projects approach focuses on creating value for all stakeholders in the ngi community and facilitating access to ngi resources and funding for dcic initiatives it leverages the consortiums deep understanding of ngi tools and mechanisms and its wellestablished connections across europe and beyond the project will conduct a thorough economic analysis of the ngi initiatives impact and the broader dcic landscape which will contribute to creating a strategic agenda for supporting digital commons throughout the current mff period and beyondthe main objective is to help the ngi initiative to integrate and align with other european and national digital commons policies in order to develop a longterm strategy that is critical for sovereignty trust and european democratic values the ultimate ambition is to create a more coherent european funding landscape to make the digital commons a core building block of eu digital sovereignty and public digital infrastructure
individual motivations and collective responses to gig work among medical doctors

md gig examines the transition to digital service provision in the public services by exploring the rise of the online doctor that provide consultations between doctorpatient via appbased mobile phone technology the aim is to explore digitalization of healthcare from a worker perspective to highlight the preconditions that give rise to gig work in the healthcare sector and explore the potential consequences at different scales whereas before all patients had go to a primary care center on appointment during office hours today patients can have a consult with a doctor ondemand at any time and from anywhere medical works entry into the platform economy where work is reshaped into gigs that workers perform where and when they want is developing parallel to organizational and economic restructuring of the healthcare system towards more marketization and privatepublic partnerships the project sets out to understand the individual motivations for doctors to take up work in digital doctor platforms through indepth interviews to produce narratives based in the mds own experiences to explore the approach of the trade unions and medical associations to digital doctor platforms through expertinterviews with high level union employees to document their hopes fears and strategies regarding changing labour markets and working conditions and to analyse the role of digital doctor platforms in public healthcare restructuring to produce a political economy of digital healthcare in europe
internal fortress regulating european freedom of movement within the nationstate 19501980

against the prevailing view that freedom of movement lowered internal barriers to movement while raising walls against outsiders to create a fortress europe this project investigates how the introduction of freedom of movement may have strengthened national political authority over european migration within the member states of the european economic community eec internalfortress suggests that as governments gradually lifted entry restrictions across the eec they also built out new internal administrative machinery to insert community migrants into key areas of social and economic life placing migrants from outside the bloc at a disadvantage within local communities the project explores this hypothesis in three key areas social security skill development and union participation the pi will lead a team of two phd researchers and one postdoc to deploy a methodologically innovative multilayered research program that analyses the interplay between national european and international institutions as well as the private ngo networks that flowed between those formal frameworks in contrast to previous histories of freedom of movement which explain policy outcomes leading up to todays regime of european citizenship internalfortress makes an important interpretive innovation by focusing squarely on the early process of transition from the 1950s to the 1970s the project will investigate how the improvised nature of early integration created gaps and tensions that were consolidated in the 1970s as national and regional migration policies settled into more rigid patterns internalfortress suggests that policies behind the border matter as much as policies at the border for understanding the acrimonious debates around european migration that continue through the present
cooling electronic devices with graphene electrons

devices such as mobile phones computers and batteries have become an integrated part of our society an important challenge in such devices and device components is to avoid overheating by using suitable thermal management currently this typically relies on heat dissipation by electrons in metals such as copper more recent approaches have explored heat dissipation by phonons in graphene and related materials which can have a thermal conductivity that is an order of magnitude higher than that of typical metals in this project we aim to demonstrate thermal management technology where heat dissipation takes place by graphene electrons rather than phonons this is a promising approach as the thermal conductivity of graphene electrons can be another order of magnitude larger than that of graphene phonons as we recently demonstrated in our ercfunded research furthermore it allows for direct electronic heat dissipation without the intermediate step via phonons the two main objectives of this project are i to demonstrate grapheneelectronbased heat dissipation in relevant electronic devices and ii to develop a business creation plan related to this technology these objectives will be addressed by an experienced and multidisciplinary team consisting of scientists technologists and business developers on the technical level we will fabricate and characterize three specific proofofconcept demonstrator devices on the commercial level we will work on intellectual property protection leverage our network of partners from relevant industries and design a business creation strategy there will be constant feedback between the technical level and the commercial level of the project in order to establish how the technology will create the most added value adapted to the market needs and thereby create most value for society
research on materials ageing and structural integrity of research reactors

many of the existing research reactors rr in europe are very old 60 years operation only few initiatives are taken pallas and jhr to partially replace this capacity continued operation of these rrs is mandatory at least until the new reactors come to operation to maintain the eu excellence in development and qualification of nuclear materials for advanced reactor concepts and to maintain the supply of medical isotopes license extensions for continued safe operation cso requires ageing management review amr and time limited ageing analysis tlaa of critical structures and components however there is limited understanding of damage mechanisms and lack of materials data on rr materials at relevant operating conditions for long term operation of rrs in addition there is a shortage of surveillance specimens for extending the operational life for some rrs lastly sharing of knowledge and operational experience is crucial in this relatively small rr communitymagicrr addresses aforementioned issues by leveraging 1 available archive materials and data from the existing research reactors eg from surveillance programs and shut down reactors 2 operational experience of research reactor operators and 3 advanced characterization and modelling techniques at universities and nuclear research centers to achieve this goal magicrr focuses on the following topics in order to cso of european rrsimproved understanding on irradiation induced damage in rr structural materials specifically al alloys at high fluence conditionsapplication of advanced multiscale modelling methods for prediction of irradiation influence on mechanical properties investigation of corrosion mechanisms and its preventionmitigationassessment of subsize testing for surveillance programssharing knowledge on reactor operation and providing guidelines on best practicesstructural integrity assessment of critical components of rrs to support cso of rrs
visionary roadmaps crafting an inclusive and participatory european democracy with youth and communities youth for europe yourope

european democracy is presently challenged by the rise of authoritarianism political extremism misinformation and the decreasing engagement of underrepresented youth yourope addresses the traditionally low political participation rates among especially underrepresented youth by tapping into their potential and aspirations through innovative approaches yourope aspires to transform european citizenship and democracy by enhancing youth involvement creating a more inclusive democratic process and developing policies that align with the different needs perspectives and ambitions of european youth especially those who are currently underrepresented yourope is dedicated to reinvigorating european democracy by enhancing inclusivity and participation particularly focusing on underrepresented youth and their communities this is achieved by establishing shared democratic spaces and roadmaps through the innovative communityled research and action clra methodology in combination with quantitative methods this democratic methodology promotes a reciprocal environment of learning and action within educational institutions recognizing their significant role in advancing european citizenship and democracy it also ensures that strategies are grounded in evidence sustainable iterative extensive in scale and fundamentally participatory educational institutions are pivotal in this effort acting as catalysts for democratic engagement in these settings young individuals and their communities will collaboratively develop inclusive participatory democratic spaces and roadmaps yourope will implement this approach in 21 educational institutions involving 630 young individuals and 6300 community members connecting them directly with over 30 european policymakers the projects vision extends far beyond its immediate timeframe intending to establish a basis for continuous research and action on future democratic scenarios for europe
integrated quantum repeater nodes

recent breakthroughs in the field of quantum technologies combining academic and rd efforts have demonstrated the potential of quantum networks for major applications such as longdistance secure communication or quantum cloud computing one current challenge is to deploy quantum networks out of the lab for realizing their expected farreaching societal and economic impact a crucial requirement for reaching this goal is the realization of a quantum repeater that will be able to extend quantum links to continental distances in this context the use of integrated photonic platforms allowing for lowfootprint alignmentfree and massmanufacturable quantum nodes represents a significant resource for reallife applications of quantum networks in this proposal we provide a route for achieving this goal through the integration of rareearth quantum memories on fiberpigtailed glass photonic chips this technology enables the storage of single photons in a platform that is compatible with integrated photonic circuits used to perform quantum gates and computations we will demonstrate for the first time ondemand retrieval of photons in an allfiber quantum memory then build the first elementary integrated quantum memory node with a multimemory photonic chip that could readily be embedded in a dlczlike quantum repeater architecture the goals set in this proposal are important milestones towards the achievement of robust applicationready quantum networks and the establishment of a european quantum internet