Dragon09/odtu_chatbot huggingface dataset:
using cardiac simulations to run insilico clinical trials

clinical trials are a key tool for advancing medical knowledge but they consist of a long and costly process entailing the recruitment of a representative cohort of participants to properly account for the population statistical variability computational engineering is a promising approach to gain more insight into patients cardiac pathologies and to test innovative medical devices before running conclusive invivo experiments on animals or medical trials on humans this technological breakthrough however is limited by some technical and epistemic challenges i the reliability of cardiovascular computational models depends on the accurate solution of the hemodynamics coupled with the deforming biologic tissues ii the resulting multiphysics solver requires an immense computational power and long timetoresults iii a great variability among individuals exists thus calling for a statistical approach for the first time i will accomplish and employ a computational platform for determining the outcome of pathologies or devices implantation by combining my gpuaccelerated multiphysics solver for the accurate solution of cardiac dynamics with an uncertainty quantification analysis to account for the individuals variability the input parameters of the computational model will be treated as aleatory variables whose probability distribution function will be obtained using threedimensional datasets of cardiac configurations available to the pis group and acquired invivo by the clinical members involved in the project simulation campaigns rather than a single simulation will be then run in order to sweep the uncertain input distributions and obtain the synthetic population response in the case of selected pathologies like myocardial infarction and the optimal stimulation pattern for cardiac resynchronization therapy my approach removes the main barrier that keeps up from a systematic use of computational engineering to run insilico clinical trials
spacebased sst mission system and sensors network horizon europe top3

this horizon europe grant is to be understood within a wider context on eusst where other grants are being executed simultaneously with the common objective of improving the eu autonomy on space surveillance and trackingin particular this top focuses on study and assess several technical solutions for the development of a future european capability of sbss explore the use of small satellite solutions to reduce capex and opex to develop in the midterm the european capacity to operate independently sbss to reduce the dependence on critical sbss technologies and capabilities from outside europethe is the first activity related to sbss within eusst
a sustainable ecosystem for the innovative resource recovery and complex ore extraction

xtract seeks to introduce the novel concept of the zero emission mine of the future introducing innovative technologies for sustainable and decarbonised extraction the xtract technological pathways to a lower mining emission future are addressing wellidentified emission intensive points of the current mining value chain xtract will add a highly innovative new alternative to the toolbox of how stockpiles and tailings are assessed relieving the pressure on resources and contributing to the realization of eu climate neutrality goals with a significant benefit of emission reduction xtract will scale remote sensing systems and analytical resources to allow the systematic and remote monitoring of hardtoaccess mining sites and waste deposits xtract targets the reduction of ore losses and mining waste through a novel system for the control of the ore loss and dilution reducing overall mine emissions and economic loss the trend towards declining orebody grades and continued development of the pursuit of existing operation to exploit lower grade deposits is likely to continue in the absence of highgrade project discovery xtract will develop and validate innovative microinvasive technologies and solutions to extract hightech elements from minerals and wastes specifically tailored to remote hardtoreach locations and small quantities where extraction is unprofitable the insitu bioleaching process and membrane treatment will be applied and optimized with the aim to achieve enhanced microbial activity catalyst production and therefore maximum metal recovery from the source xtract will introduce lowtrl green technologies of phytoextraction and phytoremediation particularly appropriate for mining waste piles and abandoned sites that represent a solution for mine waste remediation but also for the extraction and recovery of various precious metals xtract will be validated in 5 case studies in germany sweden portugal and greece
the first broadspectrum treatment against pandemicprone flaviviral infections dengue westnile and zika

who governments and health institutes are urgently seeking methods to prevent future catastrophic flavivirus outbreaks affecting millions annually 40 of the global population at risk resulting in 395m infections 25000 deaths of which mainly children 750000 disabilityadjusted life years and 9b direct indirect costs as there are no effective treatments or vaccines available atlas will provide a breakthrough in broadspectrum antivirals the firstinclass drug to combat the global health emergency of flaviviral infections in the atlas project protinhi will finalize clinical trialenabling studies and pharmaceutical development and obtain proofofconcept in humans by conducting phase i and phase iia clinical trials against the most common flavivirus dengue this will put the company in an excellent position to attract interest from pharmaceutical companies eg gilead jj msd for a strategic partnership for late clinical development and commercialization
hightc josephson neurons and synapses towards ultrafast and energy efficient superconducting neuromorphic computing

we aim at realizing a novel class of hightemperature josephson junctions jjs that behave as artificial neurons and synapses these jjs will enable a new neuromorphic computing paradigm in which neural networks are much faster more energy efficient and compact than with nonsuperconducting approaches and possess novel capabilities combined sensitivity to light magnetic and electric fields via these rupture ingredients josephine will dramatically enhance the impact of neuromorphics on its broad range of projected applications from artificial intelligence where it would allow supercomputerlevel processors at a fraction of the environmental cost to the control of autonomous vehicles the internet of things and novel medical applications that constitutes the longterm vision for the science we propose to reach that goal we will use different strategies to realize hightc josephson junctions whose weaklinks are active and can be changed in operando by external stimuli those strategies include weak links modified by a nanoscale redox reaction by the motion of domain walls in a ferromagnet or by locally doping a graphene or a 2d semiconductor once realized these jjs will be implemented and tested in neural networks to demonstrate their performance and their transformative effect on neuromorphics the proposed strategy exploits recent breakthrough results of the partners physical effects that will be implemented and synergizes their complementary expertise via a multidisciplinary approach that marries traditionally distant disciplines neural network engineering superconducting electronics and various facets of solidstate physics superconductivity magnetism dirac materials and electrochemistry
developing grafting to enable hybridisation of new species for agriculture and forestry

modern agriculture depends on developing new crops and techniques to enhance yields disease resistance and tolerance to drought and extreme temperatures one such innovation has been the development of plant grafting whereby two plants are cut and joined together to combine their best properties at the graft junction cells from the different plants expand divide and in some instances exchange genetic material including dna this exchange of dna forms hybrid cells between the two plants our ability to graft distantly related plants is growing and thus hybridisation at the graft junction is a promising means to allow plants to hybridise that normally could not however how tissues fuse and cells hybridise remains largely unknown and our ability to exploit this hybridisation technology remains limitedin graftable i will consolidate my expertise in plant grafting and build a dedicated team to identify the processes and molecular players that contribute to tissue fusion and dna exchange at the graft junction in the model plant arabidopsis thaliana using a combination of advanced microscopy techniques single cell sequencing and genetic screens i will identify how cells hybridise and determine which genes and cells contribute to hybrid cell formation using this information i will deploy chemicals and novel grafting techniques to enhance hybridisation rates and to develop transgene free methods for hybrid formation graft hybrids will be generated from arabidopsis thaliana to its relatives and also from various agriculturally relevant speciesby unravelling the molecular and developmental processes that occur at the graft junction graftable will provide fundamental information to better understand how different plants fuse tissues how hybrids form and develop novel methodologies to isolate and grow hybrids such hybrids could overcome breeding barriers and combine genomes from two species to form superior plants for agriculture and forestry
full spectrum solar direct air capture conversion

ethylene is the chemical industrys primary building block soldacs ambition is to reinvent the ethylene industry by proving trl4 an emerging breakthrough technology for producing technically and economically competitive socially desirable and climateneutral sustainable ethylene and coproduct ethanol c2 products from solar energy and air the project features a photoelectrochemical conversion pec unit being electrochemistry the only possible route for direct conversion of carbon dioxide into ethylene the pec exploits bandwidthselected light from a solar collector fss that splits the solar spectrum for electricity and heat generation at efficiency higher than standalone pv modules and standalone solar thermal collectors heat is used in an innovative direct air capture dac unit at ultralow temperature 60c fostering the eventual circular integration with heat networks the dac unit removes carbon dioxide from the air concentrates it to 95 and compresses it to feed the pec stack and a pipeline for carbon dioxide storage this allows the carbon footprint of the whole suntochemicals process to be offset and enables gain in carbon credits opening an opportunity to exceed climateneutrality and produce carbonnegative c2 products the process is energetically selfsufficient economically viable and carbonnegative on the condition that each unit dac pec fss reach new targets in efficiency that is exactly the highriskhigh return outcome expected in the project the research is balanced to overcome technical earlystage social and market barriers by exploiting the expertise of its 8 partners smes in the renewable technology field leading eu research institutions and one networking ngo this project performs all the necessary groundwork for the full deployment of the process before 2050 through activities that build up a new ecosystem of stakeholders making europe the first circular climateneutral and sustainable economy
linker molecules convert commercial fluorophores into tailored functional probes during biolabeling

fluorescence techniques are indispensable tools at the heart of basic research medical diagnostics cancer research personalized medicine and drug screening their merits are not limited by physical instrumentation but by the performance and properties of the employed fluorescent probes all commercially available fluorophores with a market potential of 2 billion per year and an annual growth rate of 8 suffer from three fundamental problems i phototoxicity and poor signal quality ii requirement for functional properties such as blinking emission sensor capabilities or high photostability and iii their limitations to be used in more than one specific application eg for lipidstaining organelle marking dna sequencing or singlemolecule detection consequences of these problems can be loss of information in biomedical assays eg via a too rapidly vanishing signal resulting for example in an incorrect medical diagnosis or false positive hits in drug screening my lab has developed a solution to these fundamental problems within the context of my erc starting grant smimport we established a versatile class of linker compounds that allow selective labelling of biological targets in vitro and in vivo with a commercial fluorophore which becomes tuneable in all of its properties via the linker with such a simple strategy users in all branches of academic and industry research but also in biomedicine will be able to modify properties of commercially available fluorophores preserving their standard labelling protocols reducing assay costs and improving reliability in this proofofconcept grant i want to explore the potential of our established linker library for commercial use
demonstration of dunedike hybrid bluegrey naturebased solutions

dunefront will demonstrate bluegrey coastal and marine infrastructure as a new generation of sustainable inclusive and aesthetic solution to ensure coastal safety under climate change the project has the ambition to cocreate hybrid dunedike nature based solutions ddhybrid nbs that can efficiently integrate static hard infrastructure with adaptive dynamic aeolian and vegetated sediments mainstreaming biodiversity into marine and coastal ddhybrid nbs is essential to jointly safeguard human assets blue economy activities and biodiversity gain and restoration dunefront will achieve this challenge by identifying key biological physical and socioeconomic boundary conditions and by translating evidence on biodiversity morphodynamics and safety from 12 demonstrators along vulnerable european coasts into new roadmaps for ddhybrid nbs design and installation the integration of this multidisciplinary knowledge into physical and digital twins will pilot the development of a decisionsupportsystem coastal and marine infrastructure blueprints and the installation of new prototypes along one of the most recreated coasts dunefront will provide a wide range of stakeholders with design installation and marketripe business plans for ddhybrid nbs translation of new research and innovations into the dunefront targeted actions will occur within a full cocreationprocedure
technology of protein delivery in extracellular vesicleinduced cardiac repair

more than 35 million people are newly diagnosed with heart failure every year in europe with a longterm prognosis of 50 mortality within 4 years there is a major need for more innovative regenerative therapies that have the potential to change the course of disease in the ercextracellular vesicleinspired cardiac repair evicare i hypothesized that we can recondition heart failure by stimulating cardiac repair with extracellular vesicles that are derived from progenitor cells from the evicare application results however we realized that enhancing the therapeutic load of evs will enhance their functional effect size to treat chronic diseases in topevicaretechnology of protein delivery in extracellular vesicleinduced cardiac repair i aim to explore active loading and release systems that will allow protein therapeutic loading in extracellular vesicles to stimulate myocardial repairwithin this project i aim toivalidate our innovative evloading strategy by assessing biodistribution and functional delivery in vivo and exploring the potential for upscaling gmp production to meet industry standards and requirementsiiconduct a comprehensive intellectual property ip landscape analysis to establish freedomtooperate fto and ensure that our technology can be commercialized without infringing on existing patentsiiiexecute an indepth market competitor and stakeholder analysis to identify strategic opportunities and potential challenges in the evbased therapeutic landscape andivdevelop a robust and detailed business plan to effectively guide the commercialization of our loading technology thus bringing a transformative solution to the treatment of various diseases
delisalto description of the extended lifetime and its influence on the safety operation and construction materials performance long term operation with no compromises in the safety

the aim of the project is to determine the most affected and threatened components from the point of view of the longterm operation lto and describe the effect of the lto on the material properties as well as develop a simulation tool able to predict the nonacceptable state of the material the project is specifically focused on the waterwater energetic reactor vver nevertheless the approach is to maintain the easy transferability to other light water reactor technologies as well the outputs of the project will lead to the increase of operational safety at the extended lifetime due to the intime prediction of the potential failure the basic approach of the project is to combine the development of the simulation tools experimental work material analyses inservice andor nondestructive inspection techniques to develop the effective early warning tool for the assessment of the system integrity for the lto of the current lwr with a specific focus on the vver technologythe projects aim specifically focuses on the thermal aging and swelling of the loaded constructional materials one of the most affected components from the ltos point of view are the heat exchanging tubes of steam generators thermal ageing and reactor internals swelling the experimental material was screened and selected with the main criteria to support and validate the proposed methods in the most accurate way and to be on stock and available at the expected start of the project the latest the experiments are planned to be performed at the available material with clear and welldescribed operational history as well as the material from the original batch in the asreceived state to gain the most relevant and valuable information with high impact to the community
unveiling eu regulatory design a contentoriented analysis of regulation in the european union

a major challenge of the regulatory governance scholarship is to develop effective measures for capturing the content of regulation in european union eu studies the lack of contentbased measures of regulation impedes the ability to analyze regulatory designs across diverse policy areas explain whether regulatory design choices are driven by euroscepticism institutional or sectorial factors and investigate how configurations of regulatory design elements affect transposition dynamics addressing these challenges euregs main objective is to analyze and explain the variation of regulatory designs across eu policy areas and investigate their transposition through a contentbased analysis of eu rules leveraging on my experience in computational text analysis along with scientific and transferable skills training i introduce a new unit of analysis of regulation the regulative statement and analyze four content elements of regulatory design actors stringency aims and issues this approach is applied to analyzing eu regulatory design across 21 policy areas from 1993 to 2023 through computational text analysis explaining its variation through panel analysis and investigating the transposition of environmental regulatory design through fuzzyset qualitative comparative analysis euregs efforts have scientific societal and economic impacts scientifically it introduces a unique measure of regulation and advances original theoretical arguments about the origins and effects of eu regulatory design societally and economically it simplifies eu rules and improves the assessment of eu regulatory burden aligning with the core missions of the european commissions better regulation agenda the facilities and mentorship provided by the host institution lmu prof christoph knill and the secondment institution uantwerpen prof koen verhoest will contribute to achieving euregs objectives and fostering my development as an independent researcher
africas silicon landscapes negotiating information and communication technology in lagos

to improve our understanding of the interactions and negotiations between society and information and communication technologies icts in subsaharan african silicon places lagostech will investigate the experiences of technology in and the digital creativity emanating from two technological nodes yaba and talent city in lagos nigeria is home to the largest number of tech hubs in africa but paradoxically is also where silicon places have received the least scholarly attention studies of silicon valley reveal how technologically saturated places strongly influence social relationships and individual experiences while producing a variety of perceptions of technology yet despite the eus strong interest in digitalisation processes in africa previous studies on african technological nodes focused on entrepreneurs investment strategies within tech hubs paying scarce attention to hightech communities sociocultural characteristics and to the broader reasons behind their development lagostech aims to fill this gap by analysing lagos innovation clusters in everyday life with a focus on the negotiation of technology contracts that is the social dynamics through which icts are accepted amended or rejected ultimately leading to the emergence or the disappearance of these communities through ethnographic fieldwork lagostech will look at the stories discourses and practices of tech entrepreneurs experts users and consumers revealing how they imagine their digital futures and the interweaving between people and icts in addition to advancing knowledge in disciplines such as anthropology sociology african studies sts and silicon valley studies the projects findings will facilitate a broader reconsideration of icts in africa leading to improved collaboration between european and subsaharan african stakeholders