Dragon09/odtu_chatbot huggingface dataset:
artificial intelligence guided develpment of vanillinbased flow batteries

the grand challenge ahead is to shift fossildominated centralized energy systems towards regenerative integrated multivector grids this requires also sustainable electrical energy storage including the related raw material supply processes and systems a real impact on economy society and ecology is only created if materials processes and products can be potentially transferred to large scale this represents a particular challenge for mid to long term systemsintegrated energy storage also because the eu strongly depends on critical raw materials from politically instable regions in vanillaflow we develop radically new approaches for integrated energy storage which combine artificial intelligence ai and machine learning ml with flow battery technology to replace currently employed nonsustainable and critical raw materials ie redoxactive molecules membranes in flow batteries by readilyavailable renewable materials based on starch and lignocellulosics vanillaflow will use ai and ml techniques such as physicsinformed modeling causal discovery and representation learning and makes use of deep learning and symbolic regression these approaches are used in designing redox active quinones and to optimize their interplay with the other components of a battery on single and multicell level the whole research will be guided by toxicology investigations to ensure that sustainable and inherently safe materials will be obtained in the project today the innovation capacity of european scientists and industry in the area of renewable materials makes them already the leading global players in the field vanillaflow will further support the european technological leadership in the area by crossfertilization of different fields artificial intelligence battery technology pulp and paper biotechnology polymer technology toxicity while addressing needs of sustainable materials in mid to long term energy storage
intentbased data operation in the computing continuum

the eu strategic autonomy in the digital economy requires more and more data to be processed in the cloudedgeiot computing continuum instead of only the central cloud this requires advanced automation and intelligence of the continuum at the same time recent breakthroughs in ai research have shown unprecedented intelligence to handle creative tasks such humanlike intelligence will eventually disrupt how people use the cloud and continuum intend aims at bringing such humanlike intelligence into the cognitive continuum to achieve the novel concept of intentbased data operation which is capable of 1 continually learning how to manage and adapt heterogeneous cloudedge resources for more efficient data processing 2 strategic decision making across the decentralized continuum for endtoend data security and sustainability and 3 humanfriendly interaction with data stakeholders in natural language for effective and trustworthy humanentric data operation to achieve this ambitious objective intend builds a strong consortium of worldclass ai researchers and leading companies that cover the complete supply chain of the computing continuum the project will deliver 11 novel software tools which integrate into an intend toolbox the approach and the tools will be tested and validated on 5 vertical domains to achieve the novel intentbased data operation for video streaming pipelines machine data platform 5g data infrastructure urban data space and robotic ai applications an open platform will be provided to support the extension with new hardware management tools and ai models into the cognitive continuum the outputs pave the way of migrating eus data industry from cloud to the continuum and implements ecs strategy of humancentric ai in the domain of data processing and computing continuum
optimise and predict antidepressant efficacy for patient with major depressive disorders using multiomics analysis and aipredictive tool

280m of people worldwide suffers from major depressive disorders mdd although a wellpopulated therapeutic landscape of antidepre280m of people worldwide suffers from major depressive disorders mdd although a wellpopulated therapeutic landscape of antidepressants the number of patients in remission is particularly low with not more than 6 of the patients who benefit from the current therapeutic journey opade objective is to identify key biomarkers that support the decisionmaking process of the healthcare providersthe project focuses on the microbiota brain axis which plays a major role in mental health and in particular mdd through clinical investigations the consortium partners will study the combination between genetics epigenetics microbiome and inflammatory networks to establish patient profiles to predict and optimise the efficacy of the antidepressants prescribed with an increase in the remission rate and reduction of impairment of reallife functioning establish the possible correlation between neuroinflammatory indices target indicators of the microbiome metabolomics immuneprofile linked epigenomic enzymatic algorithmsevaluate molecular and nonmolecular biomarkers that may represent predictive indices of recurrencediscover new molecular targets for a personalised approachimprove the diagnostic accuracy for primary preventionevaluate retrospectively using accurate anamnesis the onset of depressive symptoms in adolescenceestablish how much and to what extent do blood biomarkers correlate with other specific biomarkers350 patients between 14 and 50 years will be recruited in 6 eu and international countries for 24 months realtime eeg and patient cognitive assessment will be collected with blood stool and saliva samples results and analysis will be used to train the ai ml predictive tool the main outcome of the project a patient empowerment tool will be deployed over the project duration
seqana gmbh

seqana empowers the agents of climate positive action to maximize the impact of naturebased climate solutions ncssoil organic carbon soc growth is an essential component in the fight against climate change for trustworthy certification project developers of ncs require reliable quantification of carbon sequestration in soils existing solutions for mandatory monitoring reporting and verification mrv are one of the main drivers of cost and effort and the limiting factor for new project developmentas a carbon data analytics company we provide a breakthrough satellitebased saas software as a service solutionto date there is no tailormade solution for this use case that provides better or even similar customer value our service powered by earth observation is low in cost up to 90 lower then established services has the highest accuracy up to 30 more accurate than current comparable approaches and is easy to use and available on any digital device
bulk nanostructured tungsten for extreme environments

tungsten possesses the highest melting point amongst metals and exhibits superior characteristics when sustaining extreme environments nevertheless tungsten also has a severe limitation it is intrinsically brittle and prone to cleavage failure in our erc consolidator grant toughit we are developing strategies to overcome this brittleness while concurrently enhancing the material strength this is accomplished by refining tungsten to a nanocrystalline state via extreme deformation and strengthening the weak interfaces through segregationdriven grain boundary engineeringin the current proof of concept project bulknanowe2 we aim to transition this knowledge to industrial application our objective is to devise efficient manufacturing procedures to create nearnetshaped bulk parts we employ spark plasma sintering using electric heating and applied pressure to facilitate swift sintering at lower temperatures the pivotal role of a nanostructured material to ensure the desired properties is realized by commencing with nanopowders these also aid synthesis by increasing sintering kinetics further the nanopowders will undergo surface modification to retard grain growth and concurrently enhance mechanical propertiesthereby we chart a course toward creating nearnetshaped components featuring distinctly tailored nanoscale microstructure and modified interfaces this innovative approach will provide a synergistic combination of desired attributes including a remarkable strength surpassing conventional bulk tungsten by 100 simultaneously the fracture toughness will at least double for a resourceefficient yet secure design paradigm attaining these highly desirable properties in an adapted industrial framework we also contribute to tungsten sourcing challenges finally we realize an environmentally conscientious and economically appealing exceptional material tailored to endure extreme environments
plateletderived integrin and tetraspaninenriched tethers as key effectors in thromboinflammation

platelets are mediators of haemostasis and thrombosis but also increasingly recognized as versatile effector cells of innate immunity the concept of thromboinflammation recognizes that thrombotic and inflammatory pathomechanisms are closely intertwined platelets thereby act as central orchestrators of immune cell trafficking vascular barrier function and organ integrity and contribute to organ injury in severe disorders with limited treatment options eg stroke sepsis ards the underlying molecular mechanisms are not knowni recently discovered an unexpected novel effector mechanism in platelets with potentially huge impact for understanding these cells in health and disease resting platelets can rapidly reorganize the entire pool of their principal adhesion receptor integrin iib3 along with its associated tetraspanins and signalling machinery into disintegration complexes discs in distinct membrane microdomains these discs serve as building blocks for a novel organelle the plateletderived integrin and tetraspaninenriched tether pitt pitts are loaded with signalling molecules ribosomes and rna and can segregate from the platelet to promote thromboinflammation also 1integrins as well as glycoprotein gpvi can be integrated into discs and deposited at discrete adhesion pointsi therefore postulate that circulating platelets have the capacity to use their principal adhesionsignalling machineries in two fundamentally different ways and thereby switch between the haemostatic and a thromboinflammatory effector programme if proven correct this would implicate a radically new paradigm in platelet biology and open new avenues for the treatment of a wide range of diseases with major societal impactpittinflame will i provide a detailed molecular composition and architecture of discs and pitts ii decipher underlying signalling networks iii identify pittinduced effects on target cells and iv deduce therapeutic strategies
materials international postdoctoral programme in materials science and engineering

the atenea programme will offer ten 30month postdoctoral research prs fellowships in the field of materials science and engineering mse a key knowledge area for many economic activities and one of the four strategic sectors of the madrids regional research and innovation smart specialization strategy s3 where the project will be implemented the programme will launch one open call during its 48 months offering highlevel interdisciplinary and intersectoral training both in core and advanced scientific topics and transferable skills after the programme the fellows will be wellversed experienced researchers with highly attractive profiles for the academic and nonacademic sectors particularly for industry imdea materials institute imdea materials is the beneficiary and coordinator of the atenea programme imdea materials is acknowledged as one of spains leading research institutions and received the mara de maeztu mdm unit of excellence accreditation from the spanish ministry of science and innovationatenea will attract researchers worldwide through open transparent and meritbased recruitment otmr principles a twostep evaluation process carried out by experienced and qualified external experts from an international intersectoral and interdisciplinary pool will guarantee the selection of firstclass researchers the atenea programme will be implemented by experienced staff in training and research support and will be governed by a consolidated management structure to guarantee its success all supervisors have an outstanding research track record and extensive experience supervising guiding and promoting young and more experienced researchersadditionally the atenea programme will allow prs to improve their career prospects by carrying out intersectoral secondments within an associated partners network of 21 organisations
solar for ice to thrust

the s4i2t project seeks to develop a costeffective and environmentally friendly solar electric water propulsion system it aims to use water as a propellant to enable autonomous spacecraft docking and propellant refilling promoting economic and environmental sustainability and facilitating inorbit servicing robotics and inspace manufacturing furthermore the project explores inspace water extraction and utilization from celestial bodies contributing to a selfsustaining circular space economy based on solar energy harvestingthe three technological elements at the projects core are1 solarelectric water electrolysis propulsion water is used as a propellant and decomposed into gaseous oxygen and hydrogen outperforming traditional chemical propulsion systems waters nontoxicity versatility and availability make it a costeffective choice it also utilizes solar energy for propulsion2 autonomous proximitydocking operations and propellant refilling water simplifies inorbit refueling reducing launch mass and extending satellite lifetimes this supports inorbit servicing and assembly enhancing the impact of solar energy harvesting3 inspace water extraction and utilization water extraction from celestial bodies combined with the other technologies creates a selfsustainable space mobility infrastructure offering longterm earthindependent operationthe project aims to achieve several breakthroughs in developing a novel solarpowered propulsion system addressing technological challenges and bottlenecks it includes the development and lab demonstration of innovative components for a solar electric water electrolysis propulsion system autonomous proximitydocking algorithms and endtoend inspace resource utilization isru validationultimately the s4i2t project strives to position europe as a leader in solarenergypowered space mobility fostering a sustainable and selfsustaining space economy
solving the time puzzle of epigenetic effects on child mental health

tempo aims to solve the newly discovered epigenetic time puzzle of child mental health recently it has been observed that common mental health problems in children eg hyperactivity poor impulsecontrol are associated with epigenetic patterns at birth a mechanism that regulates gene activity in response to genetic and environmental influences curiously however this association is lost when measuring the same epigenetic patterns later in development this discovery is highly unexpected and potentially groundbreaking the existence of timing effects could lead to new insights into the origins of mental health and open muchneeded opportunities for early risk detection yet what factors drive epigenetic timing effects how they manifest and why they occur is currently a puzzleto solve it tempo will combine innovative multidisciplinary approaches and the generation of exceptional new data in a unique set of longitudinal european cohorts to address the what where and why of epigenetic timing effects three work packages will be implemented to i systematically characterize unknown properties of epigenetic timing effects including their genomic scale specificity to mental health and persistence into adulthood using advanced quantitative methods ii locate epigenetic timing effects with greater precision by establishing whether effects are driven by epigenetic patterns in specific tissues and celltypes that are found at birth but not later in life and iii explain timing effects by disentangling the genetic and environmental origins of epigenetic timing effects on mental health drawing on the power of genetically sensitive quasiexperimental designsas well as leading a breakthrough in this emerging field and addressing a major knowledge gap at the intersection of biological and psychological sciences tempo has the potential to set in motion a paradigm shift in the way that we conceptualize understand and approach child mental health
health virtual twins for the personalised management of stroke related to atrial fibrillation

atrial fibrillation af is the most common heart arrhythmia worldwide leading to lifelimiting complications high financial burden and significant resource utilisation in europe stroke as a debilitating complication of af is amongst the commonest causes of death and the leading cause of disability af patients have a 5fold increased risk for ischaemic stroke functional recovery from afrelated stroke afrs is often unsatisfactory leading to severe disability reduced quality of life and high mortalitytargets ambition is to develop novel personalised integrated multiscale computational models virtual twins and decisionsupport tools for the afrelated stroke pathway starting from the healthy state pathophysiology and disease onset progression treatment and recovery target aims to help prevent af and afrs optimise acute management and rehabilitation reduce longterm disability provide a better quality of life for patients and caregivers and lower healthcare costswe will ensure patients are at the heart of the project and the association with experienced commercial partners will ensure the swift adoption of targets novel technologies new observational data will be collected via 4 carefully designed prospective clinical studies which will be used to test and validate the personalised tools and the virtual twin models using a clinical trial simulation virtualinsilico to demonstrate evidence of clinically meaningful resultstarget will also help consolidate existing mechanistic virtual twin models of the heart the brain and the neuromusculoskeletal system enriching these twins to deliver more complex tasks and supporting research to move towards a more integrated human virtual twin target represents a milestone project to improve the care and rehabilitation of patients with af and afrs introducing a paradigm shift in risk prediction diagnosis and management of the disease and accelerating translational research into practice
perovskite solar cells with enhanced stability and applicability

valhalla will develop perovskite solar cells and modules with power conversion efficiencies above 26 23 for modules and an extrapolated lifetime 25 years guided by ecodesign principles that decrease the environmental impact of perovskite photovoltaics scalable production processes no harmful solvents optimised use of materials circularity and recyclability only leadbased perovskites have demonstrated efficiencies and stabilities that enable to reach the targeted performance levels therefore in valhalla we focus primarily on lead based perovskites we will develop innovative encapsulation methods containing leadchelating materials that detain all lead even in broken modules circularity will be demonstrated including a full endoflife recovery of lead we will focus on vacuum and hybrid processing that eliminates the use of toxic and harmful solvents during production to increase the range of application of this sustainable technology valhalla will develop rigid flexible and semitransparent perovskites with three bandgap ranges together with their optimized charge transport materials understanding the degradation mechanisms of both cells and modules in outdoor operating conditions and developing meaningful accelerated indoor stability tests for perovskite will be a key target of valhalla the approach to stability will be from a global angle from the theoretical understanding of the role of perovskite defects composition and architecture on the intrinsic stability to the development of module encapsulation and interconnection design that will enable long operational lifetime an energy yield assessment will be performed based on outdoor stressed modules in three different european locations
european compact accelerators their applications and entrepreneurship

new technologies of compact accelerators in particular plasma accelerators and laserbased xray sources are on the verge of reaching maturity in this decade making today the perfect time to steer them towards a broader scope of applications in academia medicine and the industry training the next generation of entrepreneurminded earlystage researchers on such a disruptive technology will enable them to start successful careers with significant societal impact this is the goal we pursue with the marie skodowska curie action doctoral network epace european compact accelerators their applications and entrepreneurship epace fosters a culture of excellence innovation and critical thinking to help the next generation explore opportunities and guide it towards significant contributions in line with the eu missions emphasis is put on applications in industry muon tomography medicine flash effect with particle beams from plasma accelerators and impactful progress reduced energy consumption of particle accelerators an extensive curriculum from a worldclass european business school will help the students identify and transfer the most promising innovations into commercial products coordinated by desy epace gathers 31 industrial and academic partners in europe to provide 15 phd students with great scientific expertise a thorough awareness of eu values and a drive towards entrepreneurship
precision measurement of parity violation with quantumcontrolled and trapped chiral molecular ions

molecular chirality plays a central role in many fields ranging from reaction dynamics to drug development fundamental questions surround chiral molecules in particular why does a specific handedness prevail in natural living systems the vast majority of chemistry textbooks define the two enantiomers of chiral molecules as perfect mirror images which entails tunnelling conversion between enantiomers however a closer look reveals that the nonconservation of spatial inversion exhibited by the weak force should violate the parity symmetry in chiral molecules in qchimp we aim to answer the fundamental question is the weak force important in chemistry to this end we will realize the first trapped chiral molecular ion experiment with pristine quantum control to measure parity violation pv in molecules for the first time by detecting tiny structural differences between enantiomers we will use several advantages molecular ions have over neutrals in metrology first we will leverage the long coherence times enabled by trapped ion experiments to enhance measurement precision second molecular ions provide a promising path to generate internally cold chiral molecules populating only a few quantum states which serves as an essential ingredient of precision metrology along with high quantum efficiency in detection our main approach to measure pv will use our newly developed vibrational spectroscopy scheme that can extract pv from a racemic sample directly enhancing measurement precision and overcoming synthesis challengeseach of the aims developed in qchimp toward a measurement of pv serves as an important novel milestone for taming cold polyatomic molecules and can be applied to quantumcontrolled chemistry experiments and quantum information technology the unique experience of the pi in precision spectroscopy with molecular ion ensembles and experimental cold quantumcontrolled chemistry will be instrumental in achieving these ambitious goals