Dragon09/odtu_chatbot huggingface dataset:
chipscale optical atomic clock

optical atomic clocks are at the heart of modern technology from timekeeping to navigation to global positioning systems this project will develop the worlds first all optical atomic clock that is chip scale it will create this based on recent advances in kerr soliton microcomb technology ps mode locked lasers that are heterogeneously integrated on a chip and using novel on chip frequency doublers with vastly improved efficiency exploiting the rb85 two photon transition enables to obtain a clock signal that is vastly improved compared to todays radio frequency transition based clocks this clock can revolutionize timekeeping in both mobile airborne or space application and used in future gps networks such as galileo moreover the underlying clockwork a chipscale comb can have applications ranging from distance measurements to time and frequency metrology this consortium brings together the leading groups in europe in the domain of frequency combs microcomb technology and photonic chipscale laser integration
transcription in 4d the dynamic interplay between chromatin architecture and gene expression in developing pseudoembryos

during mammalian embryogenesis key events involving dna and regulatory molecules over seconds and nanometers affect and are affected by a major reorganization of the genetic material in the nucleus over hours and micrometers how these scales are spanned and integrated into the course of development remains a major unresolved challenge progress in this quest is difficult either because current model systems suffer from severe technical limitations or because existing analytical approaches probe individual spatial or temporal scales thus ignoring their evolving interactions traditional live imaging lacks the spatial resolution to accurately delineate chromosome organization at the scale of genes while bulk molecular assays are illsuited for studying development over time here we propose a multidisciplinary approach to the dynamics of developmental gene regulation to understand the details of the underlying mechanisms and their deployment over time we combine and apply optical moleculargenomic and theoretical tools to recently available mammalian pseudoembryos allowing unprecedented precision in developmental staging a large amount of material and easy optical access by focusing on select gene loci we track transcriptional activation and the interactions of distal dna elements in realtime along with the associated chromatin dynamics using interaction profiles our datasets are iteratively distilled into mathematical models of increasing scope converging towards an integrative dynamic polymer model that simultaneously captures longtimescale chromatin rearrangements as well as shorttimescale motions of genetic regulatory elements and transcriptional activity we then challenge these models via genome editing and temporally defined interventions by building lightcontrolled tools to affect the chromosome landscape this project aims to reshape our view of how genes are regulated during mammalian development
lighthouse coordinating and supporting the innovation ecosystem for a healthy pollution free mediterranean sea

the mission restore our oceans and waters by 2030 provides a holistic and coherent framework for developing a systemic approach to the depollution and regeneration of the basin hydrosphere which is a striking need in the mediterranean sea med in the bluemissionmed proposal a multiactor transsectorial and multidisciplinary consortium consisting of 6 ri public institutions 5 ngos 3 industrial associations and 2 smes from 5 ms and 2 ac of the med proposes to set up structure and empower a med lighthouse supporting the development and deployment of transformative innovative technological social business and governance solutions for ensuring a 3050 reduction of pollution of the basin hydrosphere by 2030 it will be an interactive multiactors digital platform able to offer to all med countriesregions and stakeholders to access the necessary knowledge and tools it will build on connect and structure existing initiatives and activities including the 9 pilot bluemed on plastics free healthy med and will exploit the ri and policy knowledge generated by the funded projectsinitiatives on the med decontamination and restoration ultimately promoting basinwide cooperation commitment and deployment of solutions addressing the mission objectives the lighthouse will also ensure i coherence alignment and monitoring of eu national and local policies initiatives and actions ongoing the med basin ii an effective provision of technical services governance and business models to support and guarantee a sustainable socioeconomic development of the basin iii a wellfunctioning basin scale innovation ecosystem attractive towards investors and businesses iv the required engagement of the society at large thanks to a robust awareness raising and citizen science approach in its implementation in the sea basin and beyond and thus v the effective deployment of mission implementation charter and piloting of the mission objectives for the med by 2025
recovering global exchanges from subsaharan africas cultural and political magazines in the age of black internationalism 191868

subsaharan africa is often bypassed in global histories and its print cultures seldom approached through a transnational lens to recover a lost history of global engagement afropress will turn to the subcontinents cultural and political magazines from the period 191868a vast yet slowly disappearing archive these magazines played key roles in effecting change from fuelling decolonisation to creating literary and artistic canons afropress advances the hypothesis that magazines shaped this transformation through their global orientation that is the way they reached out across borders within and beyond subsaharan africa to black internationalist and anticolonial networks it will examine these dynamics in five countries congobrazzaville democratic republic of congo uganda south africa and madagascar recent efforts in digitising periodicals from these countries have created the perfect opportunity to explore these sources often for the first time to address gaps in the digital record and to study the multifaceted nature of a range of periodicals afropress will assemble a team with expertise in literary and periodical studies as well as art book social and political history its innovative strategy combines interviews with historical actors and research in diverse national and private archives across europe and subsaharan africa in so doing afropress will break new ground on three levels 1 analytically it will be a milestone in our understanding of the globally interactive nature and agency of cultural and political magazines from subsaharan africa 2 methodologically it will open up periodical studies to further interdisciplinary inquiry and develop a model of exchange triangulating periodical studies world literature and postcolonial and african studies 3 empirically it will recover littleknown sources that demand scholarly engagement serving as a prompt for further digitisation efforts
nextgeneration indium gallium nitride micro leds

our method of growing pure ingan leds is completely unique we start with a layer of thin gan on a substrate this layer has the same high defect density that other existing technologies struggle with then we add a mask made of either silicon nitride or aluminum oxide introduced by us using a highresolution lithography process the mask contains tiny holes ca 100 nm in diameter which become growth sites for intrinsically defectfree ingan pyramids these pyramids are then reshaped into truncated hexagonal pyramids aka ingan platelets that are just 700 nm wide effectively a nanoled and contain the active micro led structure after regrowth on the top cplane of the ingan plateletswe can already grow the leds on 2 wafers on a sapphire substrate and we are developing new methods to grow 4 wafers on a silicon substrate our kpis pixel size 1 m internal quantum efficiency 35 fwhm 50 nm etc already outcompete current commercial options for sub2 mpixel size
biobased sustainable surfactants to foster green industry

formulations in industrial applications primarily rely on fossilbased surfactantspolymers significantly contributing to environmental pollution co2 increase microplastics and are scarcely sustainable the eu green deal demands for new chemistries based on sustainable and natural compounds effective biobased surfactants are poorly integrated in industry and in their infancy in research surftogreen will fill this gap with a completely new surfactants platform covering diverse industrial applications to replace current surfactant benchmarks surftogreen gathers a unique partnership of major industrial actors and excellence research centers with the advanced knowledge on soft matter and industrial processes fundamental to achieve this challenging goal biomass derived building blocks will be obtained from eu territorial value chains including forests and agriculture wasteside streams to diversify biomass origin and used to synthesize novel biobased surfactants the new products will cover anionic nonionic cationic zwitterionic surfactant families and biopolymersoligomers from renewable sources with no impact on the food chain the platform will be validated in three industrial demonstrators among the most fastgrowing crucial sectors ie homepersonal care textile and agriculture the compounds surface properties will be assessed against detergency interfacial and rheological behaviour polymersoligomers hydrotropes and surfactants will be used for encapsulation to protect and control the delivery of actives perfumes and compounds for plant protection digital technologies and safeandsustainable by design methodologies will assess the functionality safety and sustainability of the biobased formulations within a circular value chain framework finally extensive exploitation and communication will be carried out to promote the surftogreen advancements as a pilot to drive a paradigm shift in eu and global industry
vascularised tumour organoids on a chip with human placenta vessels as a preclinical model for anticancer therapies

vasto proof of concept aims to develop and test an innovative microfluidicbased platform which allows to evaluate the efficacy of different cell immunotherapy strategies against solid tumours for this aim we propose to microfabricate 3d solid tumour organoids with an aberrant microvascular network provided from the explant of human vessels although there are other different vesselonachip andor microvascular network formation approaches that use in vitro cell monolayers we are not aware of any solution covering human ex vivo blood vessel platform as it is proposed here therefore we aim to recreate the existent mechanochemical barriers characteristics of the tumour microenvironment in solid tumours with this novel ex vivo platformwith this technology we can define a method to evaluate the efficacy of different immunotherapybased strategies specifically we focus on studying the effectivity of different chimeric antigen receptor cart cell therapies in solid tumours hence the development of vasto harbours the interest of cart manufacturers to test these cell therapies against solid tumours we will be able to asses cart cell vascular extravasation penetration into solid tumours and the cart efficiency for tumour elimination in addition to its applicability to liver cancer the acquired knowledge in vasto also could be extrapolated to any other kind tumours but also in the development of an ex vivo platform for research in regenerative processes by incorporating organoids from healthy donors instead of malignant cells and promoting functional vasculature instead of aberrant onetherefore this human ex vivo platform will launch a new product to the market very attractive for clinical labs and companies reducing animal experiments and providing a more reliable alternative for testing different therapies against tumours and approaching a more personalized patientlike model
handling with aienhanced robotic technologies for flexible manufacturing

hartu will provide the necessary tools to implement three basic stages of parts handling ie grasping assembly and releasing these tools aim to address the key challenges for creating handling applications by means of innovative technical approaches 1 selfsupervised grasp and release planning policies identification and control 2 to learn and control contactrich assembly skills from human demonstrations 3 to develop an aibased multimodal perception for visualservoing and continuous monitoring in handling operations supported by virtual and continuous learning and 4 to develop versatile and dexterous soft grippers with electroactive fingertips hartu is an industrydriven research project that includes the deployment of technologies in 5 industrially relevant scenarios 4 manufacturing lines in different sectors automotive household appliances hand tool manufacturing and food processing and 1 in logistics to validate that the technologies can be transferred to other sectors they offer an enormous variability of products in terms of shape material and sizes this approach contributes to the 1 industrial objective of hartu ie to increase the flexibility reconfigurability and efficiency of manufacturing lines through easy to integrate and configure safe and reliable handling systems supported by tools for application development and a reference architecture it also contributes to the 2 social objective to contribute to user acceptance and adoption identification of skills development needs and compliance with the liabilitylegal and ethic aspects
disrupting noxious synergies of indoor air pollutants and their impact in childhood health and wellbeing using advanced intelligent multisensing and green interventions

while the number and types of indoor air pollutants is rising much is suspected but little is known about the impact of their potentially synergistic interactions upon human health highly susceptible populations include children allergy and asthma sufferers and a low socioeconomic background however no specific guidance is available synairg aims to reveal and quantify synergistic interactions between different pollutants affecting health from mechanisms to reallife focusing on the school setting we will develop a comprehensive and responsive multipollutant monitoring system advance environmentally friendly interventions and disseminate the generated knowledge to relevant stakeholders in accessible and actionable formats to achieve these objectives synairg will construct and deploy novel and improved sensors of chemical and biological allergens microbes pollutants these will be tested in a realworld setting in participating schools of 5 countries around europe and eventually combined into a multisensing platform in the same setting pollutants will be linked to their sources and two ecofriendly airpurifying devices will be assessed health outcome data will be obtained from children using a gamified app and prospective monitoring respecting privacy highly susceptible children such as those with allergy or asthma will act as sentinels to increase sensitivity of the system that will be able to provide stratified susceptibilityspecific alerts explainable ai will support the nearreal time analysis and response in parallel cell and mouse models will evaluate the mechanisms and complex doseresponses of the synergistic parameters synairg will thus provide fair data on air pollutants and their sources a comprehensive and personalized userfriendly solution to monitoring indoor air quality and proposals for possible interventions and an improved regulatory framework robustly supporting the zero pollution action plan synairg is part of the indoor air and health cluster
highdimensional electrical stimulation for visual prosthesis

future advanced neuroprostheses will need to transfer orders of magnitude more information to the brain than currently possible this is most urgently needed in visual prostheses improving the electrode count will be part of the solution a next generation of visual prosthesis will most probably be based on the insertion of over 1000 microelectrodes in the visual cortex still current visual prostheses use very simple stimulation patterns in which at most the stimulation amplitude is modulatedwe propose to explore a second complementary approach to brute scaling using the available electrodes more efficiently by applying sophisticated stimulation protocols our main objective is to achieve a fundamental breakthrough in the spatial resolution of electrical brain stimulation to restore vision obtaining a resolution of at least 20x the number of electrodes that are physically presentthe vast number of possible stimulation combinations calls for a radically new research methodology integrating modeling and stateoftheart neuroscience methods at every spatial scale from single neurons to the entire brain in a closedloop optimization process with this combination of techniques we will study which stimulation patterns effectively induce sufficient neural activations in higher areas ie ignition and cause visual perceptions thus we will be able to explore the vast hyperdimensional search space of possible stimulation patterns and produce a set of in vivo tested stimulation patterns that are capable of eliciting distinguishable physiological and behavioral responsesthe obtained orderofmagnitude improvement in resolution will spur the development of breakthrough prostheses that will be widely adopted by blind patients and bring the field of neural interfacing to the next level
artificial user

problem despite decades of research on humancomputer interaction hci the problem of how to predict human performance with a given user interface ui is unsolved existing computational models are limited in scope or require large datasets or expert input instead empirical methods are used that are costly and errorprone objective this project establishes the foundations of simulation intelligence in hci through computational rationality given a design and a task environment a simulator generates humanlike momenttomoment behavior autonomously from which key metrics can be computed ie for learning performance and ergonomics artificial users can be commanded using natural language without modeling expertise approach we seek a breakthrough through the theory of computational rationality that would dramatically expand the models scope and actionability the theory posits that interactive behavior is an emergent consequence of a control policy adapted to internal bounds cognition and rewards while previous work has demonstrated progress scope has been limited to simple sensorimotor tasks and required reward engineering this project will study the principles of computationally rational agents that learn skills like humans can operate autonomously and yet be commanded via natural language we design a workflow for building dramatically larger models via selfsupervised pretraining impact we develop a strong complement to existing evaluation methods in hci the pushes forward generative modeling in hci by combining theorydriven causal assumptions about people and modern ml while being deployed directly in highfidelity simulators this allows dealing with novel task environments with higher accuracy this will be a leap forward in applications of design and engineering rapid evaluation and ml realistic synthetic data in hci
environmental exposure assessment research infrastructure preparatory phase project

eirene ri research infrastructure for environmental exposure assessment in europe project prioritised in the 2021 update of the esfri roadmap fills the gap in the european infrastructural landscape and pioneers the first eu infrastructure on human exposome environmental determinants of health eirene ppp aims to prepare the implementation of eirene ri as a consolidated european research infrastructure enabling the development of advanced technologies and complementary services on the characterization of complex environmental exposures and their impact on the european population this will promote european excellence in environmental health research by providing european researchers with transnational andor virtual access to harmonised capacities unique services and comprehensive data addressing the current and future needs of public authorities
environmental metal pollution revealed in archaeological human remains

environmental metal pollution threatens us all while discussions of further prevention continue the historical dimension is rarely considered the long history of metal contamination has been well traced in natural archives eg lake sediments and peat however there is a need for longterm studies directly on humans remains to fully understand how metal pollution affected the life of our ancestors pollutedpast will fill this gap by linking new research on skeletal remains from archaeological sites with research done using natural archives the overall objective is to determine the severity of metal pollution in preindustrial populations this will be achieved by meeting four prerequisites 1 availability of high chronological resolution studies in natural archives 2 periods of contrasting pollution levels 3 areas with contrasting pollution histories and 4 availability of wellsuited and studied osteological collections the investigations will concentrate on collections from nw and se spain and se sweden selecting individuals from roman to late medieval times individuals at risk babies those with chronic infectious diseases will also be targetedthe methodological approach is based in a revolutionary combination of techniques multielemental 30 and highresolution every 200m analyses of bones bioapatite and teeth will provide critical insights into metals incorporation lead copper and mercury metals different sources and biogeochemical cycles will be researched in depth and compared with wellreconstructed pollution histories in natural archives from the selected areas lead isotopes will be used aided by mixing models to trace the sources and estimate the proportion of pollutionlead in skeletons this project will generate groundbreaking knowledge about the longterm impact of metal contamination by mining and metallurgy and explore how differences in resources management may have had consequences regarding human societies