Dragon09/odtu_chatbot huggingface dataset:
personalised bioelectronics for epithelial repair

care of chronic wounds constitutes an enormous socioeconomic burden to the european healthcare system calling for new strategies to support healing for wounds at risk as a restored epithelium will outperform any artificial scaffold in protecting the underlying tissue fast reepithelialization is the primary goal in culture models of wound healing we have shown that direct current stimulation dcs makes epithelial ruptures close up to three times faster and that the key to success is dosage this aspect is overlooked in previous clinical studies typically dcs thresholds established in cultures are lost in translation because of the lack of technologies able to support dcs on the skin in prober we will change this we will exploit technologies for making conformal metal free biocompatible dcs electrodes for skin developed in the erc stg speeder by focussing on personalisation of the bioelectronic wound dressing we will ensure that the same efficient parameter space established in culture models can be precisely replicated on actual wounds our goal is a fabrication pipeline with wound dressings tailored to the wound we will collect information on wound size and shape using lidar 3d scanning and feed this as well as impedance measurements to an automated personalisation algorithm personalisation extends beyond fabrication as the prober wound dressing will include integrated impedance sensors to ensure that dcs is adapted to the healing progress in prober we will prepare our promising concept for subsequent clinical studies which requires a functional concept for fabrication and proofofconcept demonstration we will codevelop our wound dressing together with stakeholders in healthcare and work to protect ip recruit strategic partners and form alliances for clinical translation
automated generation of dense functional and perfusable bioprinted liver constructs for transplantation

despite advances in organ transplantation technology there is still a huge shortage of transplantable organs yearly 25 of patients with endstage liver disease on the donor waiting list die emphasizing the need for alternatives to organ donations such as bioprinting bioprinting presents a promising approach for creating organs from scratch yet it faces significant hurdles due to technical and biological challenges combined with lacking standardized procedures and materials in neoliver we will develop large dense and vascularized fully functional bioprinted constructs suitable for transplantation we will achieve this by establishing a gmpconform manufacturing line for standardized production ensuring unparalleled quality and safety for future patients more specifically by using patientderived organoids and supporting cells including endothelial cells we will generate millions of multicellular spheroids as building blocks for bioprinting through laser induced forward transfer lift bioprinting techniques we will create a vascularized liver construct via precise spatial deposition of spheroids and vessels at high density by integrating this technology with extrusionbased bioprinted vessels for blood supply we will generate the worlds first autologous bioprinted liver ready for transplantation to show the safety and efficacy we will transplant the bioprinted liver constructs in immunedeficient pigs this combined with a clinical validation plan upscaling strategy and health technology assessment including patient acceptance will prepare the bioprinted liver constructs for firstinhuman trials thus neoliver presents a disruptive alternative to donor organs for patients dealing with endstage liver disease
development of operando techniques and multiscale modelling to face the zeroexcess solidstate battery challenge

green highperforming and safe batteries based on abundant materials are a key element in the transition to a carbonneutral future however to accelerate their development a deep understanding of the complex electrochemomechanical processes within the battery is required which is only accessible through advanced experimental and computational methods zeroexcess solidstate batteries where the anode is formed in situ have emerged as a promising new generation of environmentally friendly batteries with high energy density improved safety and higher costefficiency but only after solutions for nonuniform anode formation were foundin opera seven leading research institutions two synchrotron radiation facilities a smallmedium sized enterprise and a large technological company all from complementary research fields such as batteries surface and material science and multiscale modelling propose a unique strategy to face the current challenges of this technology opera relies on the development of novel operando experimental techniques at the esrf alba and desy synchrotrons and at the labscale providing complementary information on multiaxial stress fields chemical composition nucleation and growth kinetics structural defect formation and degradation of welldefined model cells with a resolution down to the atomic scale the new insights and collected multiparameter data will be incorporated into a novel multiscale modelling approach supported by machine learning algorithms this will ultimately lead to a conceptual understanding of the insitu anode formation and based on this innovative improvement approaches to enable this type of energy storage technology which will be an important step towards increasing the global competitiveness resilience and independence of the eu
origin of neurogenic electrocytes one genomic and regulatory bases of the origin of a novel cell type in vertebrates

all animals have specialized cells that can generate small electric currents such as neurons or muscle cells however the ability to generate external electric fields is restricted to only few teleost and elasmobranch species this function evolved independently at least six times generating different specialized electric organs composed of cells called electrocytes that generate these electric fields in most species electrocytes have convergently evolved from muscle cells nonetheless in apteronoidae a small tropical clade that shares a common ancestor with other fish with a myogenic electric organ electrocytes have evolved de novo from spinal cord motor neuron precursors these neurogenic electrocytes create the electric organ by packing axons with unique morphological properties no presynaptic terminal ushape with a 5fold changing diameter and unique myelination pattern however nothing is known about the molecular changes that underlie these striking evolutionary novelties to a large extent due to the difficulty to access the somas of electrocytes which are intermingled within other spinal cord cells the goal of one is to elucidate the genomic and regulatory bases of the origin of the neurogenic electrocytes in apteronoidae this will be possible thanks to the use of cuttingedge singlecell multiomics technologies which will allow us to investigate this cell type at the transcriptomic and regulatory levels for the first time aim 1 i will then use comparative approaches with close fish relatives and between neurogenic and myogenic electrocytes to identify unique and convergent evolutionary genomic patterns aim 2 altogether one will positively impact neuroscience and evolutionary research revealing new mechanisms of novel celltype evolution moreover we will discover new genetic variants that might be applied to biotechnology and biomedicine and that will further help to raise awareness of the importance of conserving biodiversity
an energyefficient ai powered portable radar system for human activity recognition

radar systems have been used in ambient sensing to track various subjects using electromagnetic waves thanks to the increasing capability of artificial intelligence algorithms in solving classification tasks human activity detection har using radar systems have become possible however most previous solutions use bulky fixed radar systems with tens to hundreds of watts of power consumption requiring rigid wall plug connection making them environmentally unfriendly and difficult to use in applications like indoor security healthcare and mobile robotsin this project we aim to develop a portable radar system for har by following a hardwaresoftware codesign approach to significantly reduce the signal processing energy consumption compared to conventional radarbased har systems on the software side we will explore novel timedomain feature extraction methods to reduce the energy consumption of radar data analysis by at least 2 times we will also apply braininspired neuromorphic principles to reduce 50 times the energy cost of stateoftheart deep neural network architectures to solve radarbased har tasks on the hardware side we will develop artificial intelligence ai accelerator hardware based on fieldprogrammable gated arrays fpgas and applicationspecific integrated circuits asics to decrease the hardware energy consumption in radar data processing by at least 10 times overall we expect the project results to revolutionize the paradigm of radar data processing to achieve over 20 times the whole system energy reduction which will significantly contribute to the target of greenhouse gas emission reduction defined in the european green deal the developed energyefficient aipowered portable radar system for har is promising to initiate a commercialized product for indoor security healthcare and mobile robot applications and it will be competitive in the rapidly growing internetofthings market worth usd 2400 billion by 2029
enabling autonomous aerial systems through operational methods and technological enhancements

the emergence of large drone systems that can be integrated with intelligent coordination technology has enabled advanced air mobility aam concepts that are poised to revolutionize a broad range of domains including transport including logistics and climate adaptation nevertheless despite commendable global initiatives southeast europe is facing challenges and delays in adopting and implementing aam in this context we introduce eusome with the mission to propel the aam ri ecosystem in this part of europe addressing specific regional challenges arising from its distinctive geographical characteristics evidently the region would heavily benefit from the development and adoption of a transformative transportation solution that has the potential to eradicate traffic congestion and provide a transformative climate adaptation solution to a heavily stressed ecosystem nevertheless the incorporation of aam presents regulatory complexities and lacks a driving force in terms of ri in aam partly due to the absence of a cohesive open ri infrastructure and adequate specialized mentoring programsthe proposed eusome excellence hub endeavors to tackle these challenges headon assuming a pivotal role in establishing aam as an integral component of the transportation landscape in the region the consortium consists of experts across the whole aam spectrum from cuttingedge research departments aircraft manufacturing civil aviation authorities relevant public agencies experts in translating research into innovation and representatives of the public society this partnership enables eusome to deliver a diversified open ri infrastructure covering all needs within the aam spectrum a regional masterplan for the adoption of easas recommendations on aam and a comprehensive mentoring training and service provider program for entities businesses public agencies etc desiring to enter the aam domain
innovative delta qualification approach for electric propulsion systems

the current medium power pps5000 thruster unit which equips several satellites uses xenon as its propellant however due to a sharp rise in costs and an emerging shortage of xenon significant impacts on the economics of certain future mission profiles such as those planned for the replacement of current geostationary geo telecommunication satellites are expected it is thus necessary to seek alternative more abundant and cheaper propellant alternatives such as krypton however today there is no european thruster available on the market in the range 25 to 5 kw qualified to be used with krypton the replacement of xenon by krypton would normally require a full qualification comprising many hours years of ground testing to be performed prior to obtain the ready for flight status as required by the current ecss standards this full qualification serves to provide a high level of confidence in the thrusters operational abilities but it is a timely and costly processinvictus proposes to implement a deltaqualification approach to extend the qualification status of an established electrical propulsion system the successful acceptance of this approach by the satellite integrator and operators will be an important stepping stone to help future programs towards a clear evolution in the ecss standards it will also be possible to generalize this approach to changes not only limited to propellant or cathode emitter material but will help address other future potential modifications driven by innovation such as changes in discharge chamber wall material or electromagnet coils settingsby the end of project the pps 5000 will be ready for flight trl8 using krypton a worldwide firstofakind based on two delta qualifications exercises xenon to krypton with the necessary adaptations to the fluidic regulator and ppu ng2 and a change from an asian to an eu supplier for the cathode emitter allowing the deployment of these thruster units by 2026
redox flow batteries charging tomorrows world through the indepth understanding and enhanced control over battery hydrodynamics

electrochemical energy storage is essential if we wish to increase the usage of intermittent energy sources such as windmills and solar panels with intermittent energy sources it is crucial that energy can be stored to meet demand when production is too low when targeting stationary storage with large capacity and long storage times redox flow batteries stand out however in order to compete with other energy storage technologies several fundamental challenges remain to be resolved mass transport limitations cell resistivities pressure losses and slow kinetics still pose major barriers that result in unsatisfactory energy efficiencies and power densitiesin recharge i propose an innovative and disruptive approach by combining for the first time pulsatile flow with precisely structured 3d electrodes the batterys performance can be accurately steered towards improved battery hydrodynamics allowing to surpass stateoftheart in terms of maximum attainable power density diminished efficiency losses and enhanced energy capacity the combination of targeting an indepth understanding into how reagent product and electrolyte transport is governed within the redox flow battery by using in operando characterisation and having perfect control over the electrode geometry and flow field design through advanced engineering approaches will result in unprecedented control over the mass transport and reaction environment this will yield a significantly improved redox flow battery with a power density of 1000 mwcm and a roundtrip efficiency above 85recharge will demonstrate the impact of achieving perfect control over the hydrodynamic and electrochemical characteristics of a redox flow battery and can thus be considered as the first step towards a new generation of redox flow batteries that will completely redesign the electrode structure and fluid control strategies towards strongly improved battery efficiencies
development of a mediumhigh temperature waste heat recovery hybrid thermal energy storage layout based on red mud a disregarded and potentially hazardous solid waste of the aluminium industry

as per an eu estimate the industrial sector accounts for 27 of the overall energy consumption and for the generation of 30 heatrelated co2 emissions industrial thermal processes account for 70 of the energy demand which translates to 208 of the entire eu energy demand waste heat recovery whr is thus one of the next frontiers for energyintensive industries thermal energy storage tes is a promising alternative to currently available whr technologies particularly for mediumhigh temperature settings latent heat storage centred on the ability of a material commonly referred to as the phase change material pcm to absorbrelease heat isothermally during its transition from one state to another faces several performance issues inherent to the materials properties encapsulating pcms in solid matrices consisting of refractory materials has been found to resolve most of these issues these new materials can be used to store both sensible and latent heat hybrid tes potentially outperforming current tes systems the properties of red mud rm a currently disregarded and potentially hazardous waste of the aluminium industry make it an ideal candidate for pcm encapsulation redtherm aims to scale up the recently discovered by the researcher red mudmolten salt material and demonstrate for the first time its performance in a novel mediumhigh temperature whr layout using real industrial settings in this way it can promote a novel and tangible business case of industrial symbiosis circular economy in which the waste product of the aluminium industry rm is valorised as a key component for mediumhigh temperature whr systems to increase energy efficiency and decrease the carbon footprint of foundation industries with relevant interest steel cement casting etc this timely project can substantially contribute towards the eus 2050 sustainability agenda while in parallel expanding the science of the promising field of hybridtes
making driving safer with augmented reality

basemark is a company with a mission to improve driving safety and enjoyment through augmented reality ar focusing on the automotive ar market basemark aims to help automotive oems transition from traditional manufacturing to softwarecentric operations by providing software development tools basemarks flagship product rocksolid ar studio simplifies ar development testing and deployment for both premium and nonpremium vehicle modelsin the automotive industry there is a growing demand for advanced humanmachine interfaces hmis utilizing ar technology but there is a lack of tailored ar development tools basemark aims to address this gap with a potential 66 billion total addressable market tam
the interplay of childrens and parents networks in shaping each others social worlds

as our social worlds remain divided by categories such as ethnicity religion and social class attenuating social boundaries is paramount to creating equal opportunities and building cohesive societies segregated networks mark boundaries from childhood on and persist through adolescence and beyond research stresses parents influence on childrens contacts but it largely neglects that children also influence their parents contacts if we do not account for the interplay of childrens and parents networks we may draw wrong conclusions about how segregation emerges and under which conditions it persists or diminishes since younger generations are more diverse we must understand whether children adopt their parents network structures or whether diversity in childrens social lives also diversifies the social worlds of their parentsmy project aims to advance our knowledge of mutual intergenerational boundarymaking by developing and testing a theory of how childparent networks coevolve over time in educational settings with varying degrees of diversity i propose to collect an innovative panel dataset of childrens and parents networks for multiple cohorts from kindergarten to secondary school these unique data will allow me to rigorously examine how the interplay of childrens and parents networks affects boundaries in each others social worlds and how this varies by childrens age and diversity in educational settings by showing how children and parents shape each others social worlds the project will provide decisive new insights into the bidirectionality and conditions of the intergenerational reproduction of social boundaries this will change our understanding of segregation and break new ground in the interdisciplinary fields of intergroup relations family studies and network science the results of the project will create a firm scientific basis on which policymakers can develop measures to reduce boundaries between future generations
twinning for research excellence in sustainable development

cyprus is a hotspot of the climate crisis with the effects being more intense and difficult to cope to that end climate change in the eastern mediterranean middle east and north africa emmena region has been an object of extensive research however this research did not address to a satisfactory extent the societal aspects of climate change in the emmena region that fall under the sustainable development sd field although being very active in relevant research areas of sustainable development and in particular water renewable energy and oceanography ucy has not achieved to address the socioeconomic aspects of sustainable development research it is rather positioned in a fragmented fashion in the sd research field by having research teams involved in relevant projects and undertakings but not in a concerted way thus currently tackling important research topics sporadically and without coherence this gap is not limited to climate changerelated fields but on other aspects of sd such as gender equality innovation law science diplomacy and economic development poverty reduction and income inequalities the twin2sustain project aims to address this gap in this crucial research area by facilitating a partnership with two advanced partners in the sd field unumerit and uantwerp in order to advance and consolidate in a multidisciplinary context all related research activities at the university of cyprus ucy with main focus on the socioeconomic aspects of sd this vision will be realised by applying for a horizon europetwinning grant in conjunction and under the aegis of the research and innovation service of ucy and with many different ucy academic departments and research units engaged by linking ucy with these internationally leading partners in sd twin2sustain will stimulate research excellence and international visibility of ucy while improving the networking efficiency and innovation in this growing and very important field