Dragon09/odtu_chatbot huggingface dataset:
unravelling the potential of the wheat microbiome for the development of healthier more sustainable and resilient wheatderived food feed products

current food production systems face many challenges climate change rampant demographic development and new sustainable approaches are urgent wheat is a central crop in europe and soil and plant microbial communities are of particular interest in wheat crops since 1 they are crucial solutions for restoring soils and protecting the crops and wheatderived products against pathogens 2 they play a key role in regulating plant metabolisms and thus the quality and properties of crops and 3 they can be promising producers for a wide range of nutritional and healthy food and feed products however more studies on wheat microbiomes are needed as the current data is scarce the wheatbiome project will contribute in the understanding of the role of the wheat microbiome on sustainable development by undertaking cuttingedge research with strong collaboration between academia industry food system actors and governmental authorities distributed along 6 eu countries and will explore the role of microbiomes in wheat production systems in a broad approach from soil to plate tounderstand the effect of bioticabiotic factors on wheat microbiomes with 2 case studies and a labscale demonstratorunravel the soilplant microbiome crosstalking on wheat metabolism and nutritional quality and deliver sustainable farming practices for resilient and nutritious wheat crops via a new decision support system dssdiscover new fermentation capacities within indigenous wheat microbiomes and develop novel foods and feedsstudy the role of microbial fermentations in foodfeed quality and reduce food waste by recirculating wheat byproductsdetermine the interactions between wheat prebiotics probiotics bioactive compounds immunogenic proteins etc and the humananimal microbiota and its effect on human and animal healthassess the perception of food system actors and citizens about microbiomes within food systems
understanding metabolic activation of dendritic cells in nonalcoholic fatty liver disease

nonalcoholic fatty liver disease nafld is a major global health problem with no approved treatments and dire outcomes for patients the pathogenesis of nafld is clearly linked to metabolic alterations and is primarily characterized by excessive hepatic triglyceride content over time metabolic dysfunction induces hepatic inflammation through mechanisms that remain poorly understood this advanced disease stage called nonalcoholic steatohepatitis nash significantly raises the risk of hepatocellular carcinoma cardiovascular disease and type2 diabetes my recent work has helped demonstrate that 1 changes in conventional dendritic cell cdc populations in liver are closely associated with the development and the resolution of nash in humans and 2 extracellular metabolites can modulate cdc cytokine production and responses by rewiring their intracellular metabolic programs together these studies indicate that alterations of the local hepatic metabolite environment could affect cdc function and thereby drive nash pathogenesiscdcs coordinate innate and adaptative immunity through cytokine secretion and antigen presentation however their role in nafld pathophysiology not well defined in this ambitious multidisciplinary project my objective is to systematically dissect the immunometabolic programs and functions of hepatic cdc during nash progression and regression first we will identify diseaseassociated cdc subpopulations and their intracellular metabolic programs we will then determine whether these cdc subtypes associate with specific local metabolic microenvironments in the liver in relation to histological features of nafld finally we will determine how metabolic manipulation of cdc affects their immune function in the context of nash the present proposal has the potential to radically transform our understanding of nash pathophysiology by delineating the specific links between metabolic dysfunction and innate immunity in liver disease
deciphering the lay ethics of terminal risks local terminal risks as proxies for existential risks

the main objective of the prefer project is to open the scientific debate on existential risk to empirical enquiry the prefer team will identify how lay ethics the ethics of ordinary people manifest themselves in nonwestern communities faced with extreme threat local terminal risks due to the collapse of regional ecosystems will serve as proxies for existential risks thus this pioneering project will obtain for the first time empirical evidence on how ordinary humans evaluate and cope with reallife terminal situations existential risks concern humanity as a whole it is essential to add to the variety and number of voices heard in scientific deliberations a broader discourse on existential risk will contribute to better governance and decisionmaking around existential risks the prefer team will conduct field work in two diverse geographical areas whose inhabitants are experiencing the collapse of lifesustaining ecosystems the arctic and the mekong delta three communities in each area will serve as case studies preparatory fieldwork has revealed that members are aware of the terminal threat and have expressed fears that they are facing the end of the life they know community transdisciplinary research the coproduction of knowledge with and for local communities will be accompanied by ethnographic work data will be collected in the form of narratives which will be analyzed as sources of information on how local communities appraise the multiple dimensions of local terminal risk including descriptions the meanings drawn from these and involvement in impact mitigation actions these results will then be applied to existential risks all the while analyzing the appositeness of the prefer proxybased approach finally although the main focus is on widening the discourse on existential risks prefer will also contribute to the urgent empirical analysis of terminality in the face of collapsing regional ecosystems
research infrastructures consortium of ncps in horizon europe

rich europe is a 84 month coordination and support action built on the past experience and achievements of the research infrastructures networks funded under h2020 rich and rich2 the overall aim of the project is to improve and support the professionalisation and harmonisation of research infrastructures national contact points ncps services across europe and to contribute to the consolidation of the european research infrastructure ecosystem rich europe activities have been designed to 1 raise the general standard of support to programme applicants by enhancing ncps knowledge and capacities and building a more professionalised and collaborative ncps community 2 enhance the quality of knowledge of ris stakeholders about eu ris calls programme and raise their awareness about the transnational and virtual access opportunities to research infrastructures 3 lower the entry barriers for newcomers with a focus on widening countries 4 mainstream ris in he with a special focus on clusters and the eic programmes 5 foster the cooperation among ris at european and international level and between ris and the localregional socioeconomic ecosystemrich europe will be implemented by a consortium of 11 officially nominated ncp organizations from 10 eu member states and 1 candidate associated country the consortium has an excellent representation of widening countries more than half of the partners are from widening countries as well as experienced and less experienced ncps the project in its 7 years duration will address four major target groups i ncps for research infrastructures ii applicants in horizon europe ris calls iii research infrastructures and academia iv industries and smes
probing the quantum nature of gravity at all scales

to understand the quantum structure of spacetime we must confront proposed theories of quantum gravity with experimental data this is a challenge because quantumgravity effects are generally assumed to manifest at the planck length which lies far beyond current experimental reach i challenge this assumption by probing quantum gravity at different scales to achieve this i propose to use lever arms that translate predictions of quantum gravity at the planck scale into predictions at larger distances where we can compare them to experimental data i have identified such lever arms in particle physics black holes and cosmology the proposals first testing ground for quantum gravity is particle physics where the scale dependence of couplings is a lever arm that translates planckscale predictions into testable predictions at larger distances using this lever arm i will predict the values of couplings in the standard model and models of dark matter the second testing ground is black holes where the spin can act as a lever arm that translates planckian physics into horizonscale effects to use this lever arm i will derive spinning blackhole spacetimes and explore their image features the third testing ground is latetime cosmology where the dark energy is a lever arm that translates a microscopic interplay of scalar fields with gravity into an accelerated expansion of the universe to use this lever arm i will predict the properties of dark energythe proposals main objective to confront quantum gravity theory with observational data will thus be achieved by forging new connections between quantum gravity and other research fields these novel connections also provide a fresh perspective on longstanding questions in these other fields for example on the nature of dark matter and dark energy to demonstrate the power of these lever arms i will work in the framework of asymptotic safety a compelling framework for a quantum theory of gravity
research in europe and diversity inclusion

the publicprivate partnership readi seeks to help clinical studies cs to finally serve the complete general population and therefore more patients to date cs have struggled to recruit and retain participants from diverse backgrounds and communities such as marginalized or disadvantaged groups eg sexual gender age cultural and socioeconomic cohorts the resulting knowledge gaps entrench or increase health disparities the readi consortium strives to tackle these challenges by fostering a more cohesive and integrated cs ecosystem for underserved us and underrepresented ur communities it will actively connect all key stakeholders who can facilitate access to a wide range of patient populations it will provide these stakeholders with the necessary tools training programs and approaches essential for the recruitment and retention of usur patients in csin addition it will design build and implement a digital platform which is patientcentred sustainable open and innovative this will foster improved access to cs information and readi tools while also supporting patient connections with the created communities finally at least 4 cs will be used for testing the effectiveness of the developed tools and approaches readi has a threefold objective to help usur communities overcome cs participation barriers eg lack of informationawareness mistrust poor communication geographic limitations prejudice which in turn will improve research of many diseases and conditions preventative care and treatment effectiveness in different demographic groups and better serve society readis success will draw from its interdisciplinary multistakeholder consortium composition of 73 organizations from 18 countries with key expertise in drug development and cs design and operations engagement strategies for usur populations digital platform development training and capability building initiatives effective communication and dissemination longterm sustainability ethics and regulatory affairs
towards development of new antibacterial strategy for dentistry

argo project will be dedicated to explore innovative activities with focus on strong international interdisciplinary and intersectoral cooperation in fields of chemistry biomaterials nanotechnology microbiology cell biology and dentistry argo network will involve academic and industrial partners from eu ms and associated countries with the aim to open potential for innovative solutions in nanomaterials and clinical dentistry the primary research goal of the project is to facilitate ri activities with complementary competences of participant organizations for development of new antibacterial materials for dentistry particular for the development a new antibacterial rootfilling materialthe project will be realized through the tight cooperation between partner organizations to create synergies for development and testing of innovative biomaterials for dentistry the innovative technologies will be used to produce a rootfilling material with nanoparticles with tailored biological and antibacterial properties evaluation of a new biomaterials with silver nanoparticles in vitro will be carried out on a specially designed tooth model biocompatibility and invivo assessment will be used to prove antibacterial effect of the new biomaterial on a relevant animal model interdisciplinary and intersectoral secondment will be the main tool for project realization with aim of strengthening research training communication and networking capacities of participant organizations and knowledge transfer from academia to industry and vice versa proposed research and training goals will lead to increased research transferable skills and competences of early stage researcher with the aim to improve employability and career perspectives in both academic and industrial sectors public dissemination of new research results will increase the awareness in the general society of the role of research and researchers in development of eu as a leading destination for ri
molecular life of plants era chair

biology centre of the czech academy of sciences bc together with prof ji friml institute of science and technology austria ista are proposing the project molipec molecular life of plants era chair to create a research centre of excellence in plant molecular biology to increase research quality and capacity at bc in the czech republic and within era plant research has repeatedly provided key breakthroughs such as discovery of cells genes or transposons modern plant biology has pioneered many major discoveries in all areas of biology further molecular insights are essential for developing sustainable agriculture and plantbased industry all critical to human survival plant research has a longstanding tradition in czechia however modern molecular biology remains underdeveloped because of an antigenetics past legacy in eastern europe plant research at bc currently undergoes major structural changes providing an excellent and timely opportunity to restructure bc to achieve efficiency and excellence the era chair will be instrumental in this endeavour the project comprehensively addresses five most important areas for improvement 1 the international advisory board under era chair direction will strengthen research and leadership at bc from an international perspective 2 centralised facilities will provide professional research and administrative support improving efficiency and economical savings 3 outstanding talents will be recruited to establish two new independent research groups complementing current plant research topics 4 mentorship program and career development plan will improve ri knowledge and skills free circulation of knowledge and cooperation with business 5 targeted communication and dissemination of research results with societal relevance will ensure international attractiveness and visibility of bc thus the molipec project will establish bc as a leading centre for excellent plant research in central europe
high temperature dynamics of metals and the earths solid inner core

the earths innercore ic is 1220 km radius planet within the earth made of solid iron fe crystallizing from the outer core oc as the earth cools down the ic affects our life at the surface its growth provides a major source of energy for maintaining the earths magnetic field one may view the ic as a freezing ball of fe floating at the center of the oc but seismic exploration reveal structures of increasing complexity raising fundamental questions on the history and internal dynamics of the ic geophysical observations unearth the ic as it is today understanding the history of the ic and the effect of the ic on the global earth dynamics however requires a reconstruction based on todays observations and knowledge of the physical properties of the ic fe alloy how they could affect ic dynamics and their relation with presentday geophysical observables there are significant knowledge gaps and outdated principles regarding the underlying physical properties of the ic fe alloy the ic temperature is close to melting and the ic might even be partially molten how does temperature affect of the mechanical properties of the ic fe alloy what is the effect of temperature and partial melting on seismic observables such as wave travel time and attenuation this is poorly known and it hinders our interpretation capability of the evergrowing body of geophysical observations in hotcores advanced high pressure andor high temperature experiments will be performed on fe alloys and analogues i propose to reenact key events of the history of the ic in the laboratory as fe crystallizes at the inneroutercore boundary as the ic grows and dynamically evolves to its present state and as we see it today through the lenses of geophysical exploration what is the structure and dynamics of the ic how will the ic evolve in the future hotcores aims at providing the mineralogical foundation that will help solving these mysteries
twinning to skyrocket scientific excellence towards individual radiosensitivity prediction by raising the bar in knowledge transfer networking and technological innovation in radiobiology

prostate cancer patients receiving radiotherapy rt may develop radiationinduced side effects which significantly impact quality of life one of the main challenges in radiobiology is to predict individual patients normal tissue radiosensitivity to tailor personalized rt although the institute for oncology and radiology of serbia iors is a highly specialized health scientific and educational institution it is necessary to develop a strategic action plan and sustainable knowledge transfer networking with topclass leading european institutions through the 6 specific objectives radexiorsboost project aims to develop and implement institutional scientific strategy on radiobiology to investigate individual radiosensitivity by transcriptome profiling radiationinduced lymphocyte apoptosis and measurement of dna damage levels to design a highquality clinical study and to raise the research capacity of iors and partner institutions through 5 international workshops 8 shortterm visits and 6 trainings radexiorsboost project aims to strengthen the administrative and research management skills of iors radexiorsboost project realization will increase the scientific excellence of iors to approach highranking partner institutions medical faculty mannheim heidelberg university uhei germany the university of leicester uleic united kingdom medical university of vienna center for cancer research muw austria and the institute of oncology ljubljana iol from slovenia artificial intelligencebased models such as machine learning may give directions towards the clinical application of peripheral blood mononuclear cell transcriptome and list potential biomarkers predicting radiotoxicity not only in cancer patients but also in healthy individuals at risk radexiorsboost project may blaze the trail for technological innovations in modern radiation oncology to significantly reduce the side effects of rt and its harmful effects on the environment
transforming education with emerging technologies

transeet will forge sustainable connections and synergies between a research lab in the most historical university in widening greece and four respective highly impacting labs in leading institutions in europe it will address the problem of shaping the use of existing and emerging technologies for dynamic educational transformation aiming to meet the needs of the 21st century education is an ssh research domain which has a lot to gain from twinning between widening countries and leading research teams with complementary expertise envisioning and shaping the future of education in the digital era is a persistently illusive endeavor exacerbated by loosely understood changing educational needs emerging digital technologies and the unpredictability of societal citizenship mobility parameters transeet will significantly augment the research leadership and impact capability of a greek lab with outstanding potential yet hampered and slowed down by lagging experience in administration management and capability for international impact the project will establish a strategic program leading to the codesign implementation and outreach of educational innovations with emerging technologies such as ai vr ar 3d printing in an equal pace and range across the partners twinning will be uniquely fueled by an original method called cofe comprising of the following elements a creating four communities of interest involving diverse members and engaged in complementary joint enterprises coi b generating homegrown technologies affording a dense flow of useable rapid prototypes frp and c augmenting the coi research actors hybrid expertise to meet the interdisciplinary necessity to address this research field ahe the cofe method will aim to generate strong leadership capacity in a greek institution contribute to worldleading sustained research and innovation in a transforming education sector and impact on all the partners educational contexts
the role of cohesin dynamics at stalled replication forks

cohesin an evolutionary conserved ringshaped protein complex that topologically entraps dna has crucial roles in many structural and functional aspects of chromosomes including sister chromatid cohesion genome organization gene transcription and dna repair the importance of cohesin in the maintenance of genomic stability has been known for some time cohesin facilitates double strand breaks repair by homologous recombination and promotes the restart of stalled replication forks by template switching an errorfree dna tolerance pathway however the precise role of cohesin in dna damage and in the recovery after replication stress is still unknown whether cohesin acts exclusively providing close proximity of sister chromatids or its functions exceed simple embracing of dna has yet to be discerned cohesin has been shown to be ubiquitylated upon replication fork arrest this posttranslational modification has been proposed to favour cohesin mobilization and subsequent association with nascent dna behind the fork however the extent to what cohesin dynamics are important in the recovery after replication stress is still to be understood by a range of multidisciplinary approaches from biochemistry and enzymology yeast genetics and molecular biology techniques to high throughput proteomics and bioinformatics analysis of mass spectrometry data we will gain valuable insight about the interplay between sister chromatid cohesion and dna damage tolerance and their contribution to successful replication this basic knowledge about the mechanisms involved in dna damage responses has demonstrated to be essential in the design of successful strategies against cancer remarkably cohesin is one of the protein complexes most frequently mutated in cancer this project aims to provide valuable insight about how cohesin mutations cause tumorigenesis