Dragon09/odtu_chatbot huggingface dataset:
novel biophysical tools to measure multiple parameters in the same cell

biophysical biomarkers of cell state can reveal physiologically relevant changes that occur during disease progression for example cell deformability cytoskeletal and nuclear organization and macromolecular crowding are biophysical parameters implicated in migration and growth which are essential processes for cellular functions as biophysical parameters reflect physiopathological cell states they have the potential to be used as biomarkers for early diagnostics and clinical treatments in medicine current techniques based on microfluidics can be used to perform biophysical measurements in a highthroughput manner however these systems are not able to provide multiparameter biophysical and samecell measurements making it difficult to find insightful relationships in heterogenous cellular mixtures samemultiphys will develop and produce customized microfluidic systems to measure multiple features in the same cells and evaluate their potential applications as biophysical biomarkers these new technologies will allow us to study multiscale biological questions of immune t cells from an interdisciplinary perspective and other cell lines this project aims to facilitate the transfer of knowledge and resources between institutions with expertise in microengineering materials science chemistry mathematics biology and biophysics to promote collaboration between researchers and to develop innovative microfluidic technologies for mechanobiology the project will involve stateoftheart microfabrication techniques deeplearning analysis of images and computational modelling to develop and validate the technologies developed the ultimate goal of this project is to gain a deeper understanding of the mechanobiology of cells enabling progress toward more effective identification of biomarkers
serving the revolution educational networks in communist albania

my research explores the educational networks of albania during the cold war using several archives from albania china italy and east germany as well as conducting interviews the research investigates in what ways educational exchanges impacted albanias economic policies and the formation of an adequate specialised workforce from 1955 to 1978 when hundreds of students were sent abroad to pursue university studies albanias communist past has been little studied this project proposal contends that studying educational networks and expertise circulation would provide a complete understanding of the communist regime of albania during the 1960the overall research objective of this proposal is to understand the impact of the educational networks and expertise circulation in albanias economic policies from 1955 to 1978 the project is expected to have a major impact in the field of east european transnational networks during the cold war and albanias communist history as it will explore for the first time the importance of access to foreign expertise and technology as well as the education of specialized workforce in the building of economic and social institutions in albania historical studies may contribute to the european unions adopting adequate policies towards the balkans an important task in light of recent events in eastern europe with the war in ukraine in the meanwhile the new scientific skills in reading and processing political documents as well as learning didactics in the european union together with research methodologies acquired through the twoyears training at the department of east and southeast european history gose ludwig maximilien university lmu under the supervision of prof marijanine calic will allow me to foster my academic profile as a regional expert in east and southeast european studies thus increasing my chances to continue my career in academia by becoming a research leader in the field of cold war in europe
attracting international experienced researchers in any research field to the basque country

the economic crisis and the lack of resources devoted to research and development rd in spain is a pressing issue affecting the basque region too and it is aggravated by the european crisis provoked by the covid19 pandemic and the ukraine invasion the rd expenditure of gdp in spain has been reduced in the last decade currently it is half of the european union average which is critical the stabilization of longterm research lines led by experienced researchers as proposed by smartbrain3 is an unmet challenge that ikerbasque beneficiary proposes to address with the present programme smartbrain3 aims to offer 30 research contracts for experienced researchers within 2 calls offering 15 positions in each call the current programme offers permanent contracts as ikerbasque research professors tenure track positions to all researchers to be recruited although each fellowship will last 36 months within the smartbrain3 programme the impact of such a workforce for the basque region is welcomed as internal assessments by the basque research institutions show the lack of experienced researchers in the region smartbrain3 offers an outstanding research innovation training and career consolidation programme with specific focus on the triplei dimension international intersectoral and interdisciplinary as well as providing an impactful innovative and inclusive research environment the 24 implementing partners recruiting and hosting the fellows are leading international institutions within their respective fields smartbrain3 includes mandatory international secondments which enhance the researchers networks and let them explore intersectoral career paths as well in support of their career progress smartbrain3 ultimate impact is to contribute to the challenges and priorities set out in the ris3smart specialization strategy of the basque country the united nations sustainable development goals and the horizon europe
human based bioinks to engineer physiologically relevant tissues

bioprinting techniques which integrate 3d printing with tissue engineering by using living cells encapsulated in natural or synthetic biomaterials as bioinks are paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds new frontiers in medicine pharmaceutical and food industrieshumanink aims to validate human basedbioinks to produce robust humanized 3d environments with unprecedented biofunctionality for cell culture that fully recapitulate the native microenvironment of a variety of human tissues and organsunder this project humanprotein derivative precursors that can be cured upon light exposure to form soft hydrogels with tunable mechanical properties will be tested and validated as bioinks for 3d bioprinting such materials provide functional support for cell growth and interact with cells to control their function guiding the process of tissue morphogenesis this platform is the first to offer complete humanbased material for bioprinting and an easytouse solution to create physiologically relevant 3d in vitro cell cultures accelerate drug discovery or clinical purposesthe humanink will allow to optimize the printability robustness reproducibility and scalability of the humanbased bioinks the biological response of multiple human cell types will be investigated and the bioinks will be benchmarked with the main competitors in the marketour proposed technology will increase the probability of successful drug development while simultaneously reducing the cost and time of development and supporting animal welfare reducing animal experimentation based on the unique properties of our products humanink represents a unique opportunity to develop materials for tissue engineering and accurate disease models for bridging the gap between fundamental research and drug validation with a high and broad market potential in pharma companies clinical institutions or research groups
circadian structural transitions of chromatin

transcription factors tfs distinctly mark regions of the genome for expression and are the pillars of cell identity yet even at the basic level of dna recognition by tfs we know very little about how this is achieved in eukaryotes all dnatemplated processes occur in chromatin however most studies elucidating the molecular mechanisms of transcription have been performed on histonefree dna in the proposed project we will use tfs as centerpieces to understand how in the circadian system the interplay between transcriptional regulatory complexes and chromatin shapes the eukaryotic genome to control gene expression specifically we will use biochemical approaches paired with functional genomics and cryoem single particle and tomography to investigate how histone identity affects tfdna engagement and how tfs and histone modifications influence chromatin organization across biological scales from nucleotide sequence to chromatin structure in situ we will exploit circadian time in mammalian cells and the unicellular green algae chlamydomonas to elucidate the dynamic gene regulation of a biological system under natural conditions using diverse model organisms will enable us to reveal common conserved properties and processes ultimately these studies will provide unique insight into the fundamental mechanisms of gene regulation while dissecting the molecular mechanisms of biological timekeeping
design of intelligent risaided cellfree networks for energyefficient coexistence between embb and mmtc

in our modernized era beyond5g and 6g wireless systems will be key to satisfying crucial society demands the new challenging 6g kpi the renewed need for sustainable and green networks and the introduction of ai and sensing evinces the necessity of incorporating new technologies and of designing novel solutions in that sense cellfree massive mimo reconfigurable intelligent surfaces riss and edge intelligence are anticipated to be key technologies in the 6g era diracfec is a 24months research project that thus concentrates on the design of intelligent risaided cellfree networks for energyefficient coexistence between evolved embb embb and evolved mmtc mmtc more specifically considering usercentric architectures and distributed multiple antenna deployments we will present a set of multiple access schemes edge intelligence techniques and transmission strategies that optimize the energy efficiency in a heterogeneous service environment aiming at the coexistence of embb and mmtc services we will conceive mathematical frameworks to model dense networks where several riss are controlled by multiple antenna access points then to boost the ultimate performance we will design the aforementioned approaches for different types of data traffic under the assumption of imperfect channel knowledge these solutions will be evaluated using numerical and industry level systemlevel simulations in practical setupsthe project will be carried out by the researcher at the university of cassino and lazio meridionale italy under the supervision ofprof stefano buzzi furthermore nokia bell labs france will host the researcher for a sixmonths secondmentaimed at validation of the developed solutions on industry level system simulators the applying researcher is drsergi liesegang a fresh phd graduate from the politechnic university of barcelona spain
boosting the uptake of circular business model product and process innovation

up2circ will demonstrate a replicable pathway to motivate and effectively support smes to innovate and transform towards sustainable growth and adresses the need of eu innovation support ecosystems to better join forces and make best use of synergies in order to enable a quick and comprehensive transition of europes smes towards a circular economy on a large scale with the up2circaccelerator the project accompanies smes from exploration of opportunities to concrete implementation projects concerning the uptake of circular business model product and process innovation focussing on achievable innovation measures with clear midterm benefits for the smes up2circ is dismantling barriers with a customized clientcentric advisory approach and gives access to specific expertise and skills that smes need to develop a concrete action plan on how to transition learning modules of up2circacademy will connect sustainable innovation the uptake of advanced technologies and social innovation aspects under the holistic concept of a circular economy and will be compiled based on existing results and in close cooperation with eu networks and initiatives such as ati edih eccp eit and oitb up2circ methodology and materials will be made available to sme innovation advisors and trainings will be offered targeting eg een sustainability advisors to upscale project results further to increase efficiency of eu innovation support ecosystems four leveraging effects will be demonstrated and exploited make use of existing results reach out more efficiently to smes make use of complementary strengths establish closer connections
lifecycle extension of salvaged wooden materials through reuse in dowellaminated timber

reusing salvaged timber in new applications can make an important contribution to circular economy however currently the reuse of such materials is limited especially in structural applications one reason is the lack of demands from the wood sector due to the absence of standard grading procedures and other issues related to eg shape irregularities service damages dimensions limitation and degraded properties which will require costly significant processing that makes salvaged timber less profitable this project will demonstrate how a fitforpurpose approach can be implemented in a practical manner to reuse salvaged timber in structural applications the target application is in dowellaminated timber here ecodlt floor panels in ecodlt salvaged timber will be reused in combination with new raw timber using a new fabrication method that will not require significant processing or gluing this can reduce the processing costs which can make salvaged timber more profitable and more attractive for the wood sector the project will first evaluate the current state of salvaged timber resources in slovenia using resource inventory a resource classification method will be then established using which the reusability and profitability of reusing each resource can be determined objective 1 in the next stage the concept and fabrication method of ecodlt will be developed experimentally and its structural properties will be examined objective 2 analytical models will then be developed for predicting the structural properties of ecodlt using a new wellknown weak points concept which will consider certain strengthreducing features of salvaged timber that are not represented in the existing models objective 3 the project will contribute substantially to the eus circular economy goals and will lead to breakthrough innovation in wood cascading and analytical analysis of mass laminated timber elements with complex configurations
connecting symmetric and asymmetric cryptography for leakage and faults

symmetric asymmetric cryptography offer the basic functionalities needed to communicate securely over a channel due to their different features and the different algebraic structures they exploit the interaction between the design of these primitives and the security of their implementation against sidechannel fault attacks so far followed somewhat separated paths based on the observation that i many emerging challenges for the implementation security of symmetric asymmetric primitives share similarities and would highly benefit from a more connected approach and ii this is especially true when considering postquantum asymmetric encryption schemes that include symmetric components and for which current designs are extremely challenging to protect against sidechannel faults attacks the bridge project aims to develop a unified treatment of symmetric asymmetric cryptography by leveraging three innovative movements first we aim to export the concept of levelled implementation where different parts of a primitive are protected with countermeasures of varying cost from symmetric cryptography towards new postquantum asymmetric schemes that inherently take implementation security as a design criteria second we aim to export the use of larger possibly prime fields and more complex algebraic structures used in asymmetric cryptography to deliver advanced functionalities towards new symmetric schemes that guarantee security against sidechannel fault attacks in lownoise contexts that raise fundamental challenges for existing countermeasures third we aim to exploit hard physical learning problems as radically new building blocks applicable to both types of primitives by combining these movements we aim to identify disruptive approaches to build new cryptographic schemes offering a better integration between symmetric asymmetric designs and improvements of their implementation security by orders of magnitude
multimode nonlinear fiber based endoscopic imaging and treatment

multiscope introduces a revolutionary photonic technology that represents a significant advancement in the field of optical diagnostics and therapy our approach is based on cuttingedge research into pulse propagation within nonlinear complex structures we are developing an endoscopic device that seamlessly combines optical biopsy and cold atmospheric plasma treatment this dualfunctionality device harnesses the spatiotemporal control of powerful light in multimode fibers which were previously overlooked due to concerns about excessive light destructuring we leverage the remarkable progress in the development of the latest optical fibers and in the precise control of light within multimode guides enabling us to harness the power of plasma the fourth state of matter initially our focus is on gastrointestinal gi endoscopy but our ultimate goal is to extend this technology to all areas of medical diagnostics where there is a pressing need for reliable tools for optical biopsy and instant pathology these tools are crucial for realtime diagnosis but have not yet reached the level of trustworthiness required for widespread use endoscopy is a vital tool for diagnosing and treating gi disorders offering a safe and effective approach however the current standard of care still relies on histopathology for conclusive cancer diagnosis this leads to significant delays in initiating treatment and incurs high costs our project is set to transform this landscape by bringing to life the longanticipated concept of realtime invivo optical diagnosis often referred to as optical biopsy our groundbreaking approach seamlessly integrates endoscopic capabilities with cold atmospheric plasma therapy which employs controlled plasma jets to precisely target and eliminate cancer cells by inducing cellular apoptosis by combining plasma therapy with optical biopsy we not only provide realtime diagnosis but also offer immediate therapeutic intervention
mechanical characterisation of nucleic acids using single molecule methods

nucleic acid nasbased therapies have started to yield major advances in the treatment of human disease new approaches for understanding na structure and function are required to extend the boundaries of todays gene editing technologies cancer therapies and mrna vaccines singlemolecule techniques have revolutionised our understanding of nas and their interactions with therapeutic oligonucleotides small molecules and proteins however for europe to remain competitive in this area new expertise is urgently required in singlemolecule na analysis which intersects the fields of physical chemistry biophysics na synthesis and computation mechanism will train the next generation of european scientific leaders in the development and use of singlemolecule biophysics techniques where they will investigate critical interrelated question regarding the structure dynamics function and interactions of nas to do this our doctoral candidates dcs will unravel highresolution na structures and intramolecular forces with modified bases understand the conformation and dynamics of nas at the singlemolecule level develop nextgeneration therapeutics for treating genetic diseasesmechanism connects worldleading researchers working in the fields of singlemolecule biophysics na chemistry and computational modeling with outstanding industrial partners working in complementary fields in addition to conducting worldclass research our dcs will understand industrial needs have knowhow in running multidisciplinary research and will be immersed in a broad collaborative network connecting academia and industry our dcs will provide vital future breakthrough applications in nas and singlemolecule analysis to pharmaceutical and biotechnological industries where the design of new drugs including nabased therapeutics and vaccine technologies will provide major improvements to human health
bridging the digital divide and addressing the need of rural communities with costeffective and environmentalfriendly connectivity solutions

over the last years the importance and need for broadband and highspeed connectivity has constantly increased the covid19 pandemic has even accelerated this process towards a more connected society but this holds mainly true for urban communities in europe a 13 lack access still persists and mainly concerns the most rural and remote areas those are the most challenging to address since they are the least commercially attractive commect aims at bridging the digital divide by providing quality reliable and secure access for all in rural and remote areas the goal of extending broadband connectivity in rural and remote areas will be achieved by integrating nonterrestrial networks with terrestrial cellular xg networks and lowcost internet of things iot artificial intelligence edge and network automation will reduce energy consumption both at connectivity and computing level participatory approach with endusers and ict experts working together on development challenges will be the key for the digitalization of the sector to ensure the rich exchange of bestpractice and technical knowledge among the actors of the agroforest value chain commect will set up five living labs across and outside europe where endusers pain and connectivity gains will be largely discussed from different perspectives commect aims at contributing to a balanced territorial development of the eus rural areas and their communities by making smart agriculture and forest services accessible to all commect will facilitate that by developing a decisionmaking support tool able to advise on the best connectivity solution according to technical socioeconomic and environmental considerations this tool incorporating collaborative business models will be a key enabler for jobs business and investment in rural areas as well as for improving the quality of life in areas such as healthcare education egovernment among others
sustainble alternative to flexible packaging

paptic foam is a new material for flexible packaging combining the sustainability of paper versatility of plastics and haptics of textiles our material is compatible with the production processes of the respective flexible packaging value chain thus can be easily introduced in processing the unique haptic properties also enable consumers to differentiate the products improving efficiency of sustainability communication of endusersbrand ownerspaptic already has developed and piloted the foam technology to produce renewable recyclable and reusable woodfibre based material that is over 50 more resource efficient compared to paper paptics patented material technology has vast application opportunities in various flexible packaging market segments like dry and frozen food packaging electronics hygienic products toys etc our technology enables resource efficient manufacturing and higher product performance enabling position of most sustainable alternative to plastics