Dragon09/odtu_chatbot huggingface dataset:
wicharge the future of power

wicharge is developing a paradigmshift in wireless power systems that overcomes current limitations allowing charging devices over the air with a range of 10 meters and available power that is 100x more than batteries all this preserving health and safety requirements our technology will enable the appearance of many new devices and functionalities that today are simply not possible imagine devices can enjoy 100x500x more power than they have today and still work permanently in a wireless mode it will enable a huge breakthrough in many industries and will take user experience to the next level our goal is developing proprietary transmitters and receivers designed to operate for the 1st time at a specialized infrared ir spectrum that we found to be the best one to optimize power distance efficiency and most important safety while providing more than 100x better performance compared to solutions based on magnetic induction radiofrequency rf or ultrasound beaming
a powertoheat long duration energy storage for decarbonizing the industrial thermal processes

thermalbox combines powertoheat pth electrification technologies with thermal energy storage tes systems utilizing sensible heat storage in molten salts to deliver decarbonized industrial process steam while also providing demand side flexibility services to the grid the system is primarily powered by renewable electric energy sourced from a renewable asset or through a power purchase agreement ppa and it is capable to deliver steam up to 20 barg and 222c the heat transfer fluid htf utilized is a eutectic mixture of inorganic molten salts known as hitec extensively used in chemical and petrochemical applications consisting of potassium nitrate kno3 sodium nitrite nano2 and sodium nitrate nano3 at weight percentages of approximately 53 40 and 7 respectively the system configuration based on a twotanks arrangement ensure a smooth and continuous operation and provides operational flexibility by decoupling supply and demand thermalbox has been designed with two sets of tanks located at different elevation namely the storage system an electric heater and a steam generator systembuild to zero positions thermalbox in the small to mediumsized industrial application market focusing on delivering up to 5 mwth with costcompetitive optimized design thermalbox decarbonizes industrial heat and provides demand flexibility to electricity system operators aligned with eu market reforms the scopes of the eic accelerator project are to manufacture install and test our 25 mwth basic unit to industrialize the thermalbox production process and to enter the international market
cancer prevention at work cpw occupational health surveillance in the implementation of prevention of infectionrelated cancer

chronic infections represent a major cause of human cancer on a global scale they are responsible for an estimated 13 of human cancers helicobacter pylori hp hepatitis c virus hcv and human papilloma virus hpv are responsible together for 75 of these cases or 10 of total cancer burden de martel et al 2020 occupation health surveillance is mandatory in all european countries although the mechanisms of its implementation vary between the countries these programs are in general aimed at diagnosing and preventing workrelated diseases prevention of occupational cancers has therefore been a component of occupational health surveillance in recent years however there has been a movement towards including in occupational health surveillance aspects of health promotion which are not occupational in a strict sense this approach stems from several considerations i the contact between the worker and the health professional in charge of the surveillance can be seen as a privileged opportunity for health promotion in general ii through the worker the health promotion initiative may reach other groups of the population iii because of the periodic nature of the visits entailed by the occupational health surveillance it is possible to efficiently implement followup mechanisms the conceptual framework of the proposed research is based on the incorporation into ongoing occupational surveillance schemes of primary prevention programs against infection with hp hcv and hpv the overarching objectives of the proposed research areto conduct a series of pilot projects aimed at assessing the effectiveness including costeffectiveness of incorporating primary prevention interventions against hp hcv and hpv into existing occupational surveillance systems in highrisk populations including its impact beyond the workers directly involved in the pilot projectsto identify barriers and bottlenecks for the implementation of such interventionsthis action is part of the cancer mission cluster of projects on prevention and early detection
the next step towards the elimination of iodine deficiency and preventable iodinerelated disorders in europe

the iodine status is a primary determinant of thyroid disorders which are a major cause of morbidity particularly in women in addition even mildtomoderate iodine deficiency during pregnancy is related to neurocognitive impairment in the offspring iodine deficiency imposes tremendous costs on the healthcare systems of affected regions but can easily be prevented by iodine fortification programmes in many countries iodine deficiency receives surprisingly little publicitythe initial euthyroid consortium evaluated european prevention programmes against iodine deficiency and uncovered major limitations including the low awareness on the importance of iodine for healthy living euthyroid2 will now fill important gaps in the prevention of iodine deficiency in europe and beyond the main objective of euthyroid2 is to improve the low awareness with respect to iodine deficiencyrelated risks in adolescents and young women the major aim is to find best practice models for accessing and informing them to increase their awareness and to improve their iodine status in order to lay the foundation for their own thyroid and general health and that of their offspringimplementation studies and communitybased randomisedcontrolled trials will be conducted with the objective of increasing iodinerelated awareness in adolescents and young women up to age of 24 before pregnancy the interventions are multimodal and performed in the two settings educational system and ambulatory care in eight study regions as public health project euthyroid2 is not only science but will also serve our societies therefore dissemination of findings to various sectors of our countries and the eu will be of utmost importance by finding best practice models to raise the awareness on the importance of iodine for a healthy life of their own and their offspring in young people euthyroid2 will lay the foundation for a costeffective way to eradicate iodine deficiencyrelated disorders
investigating the molecular identity of pacemaker neurons in cortical development

spontaneous activity is a prominent feature of the immature brain even before birth and in absence of stimuli neurons organize in networks and spontaneously generate correlated activity while spontaneous dynamics in the cerebral cortex have long been overlooked and considered just as epiphenomena recent clinical data on preterm infants and preclinical studies have spurred a renewed interest for this early electrical activity however appreciation of the role of spontaneous activity during the perinatal stages remains elusive indeed it is still unknown how spontaneous patterns arise and whether among the large variety of neuronal classes generated in the cerebral cortex distinct subtypes can act as pacemaker pm neurons able to trigger some of these events defects arising from alterations in the early cortical spontaneous activity have never been thus far systematically addressed yet they can affect local assembly and physiological behavioural statesthe impact project aims to shed light on how cortical neuronal diversity influences early spontaneous activity and to identify the molecular features and functional role of developing pm neurons by integrating innovative molecular strategies with in vivo optical recordings and behavioural assays i will 1 characterise and spatially resolve the subtypespecific molecular footprints correlated with electrical profiles of neuron subtypes with a special focus on pm neurons 2 assess molecular cellular and circuit consequences of perturbations in pm neuron activity 3 identify novel functional modulators of pm activity in the surrounding cerebrospinal fluid csf around birth impact bears the ambition of filling the knowledge gap between the molecular and functional traits of developing cortical neurons while unveiling the existence and critical role of the pm neurons discovering new molecular players and modulators of early activity will inspire novel intervention strategies for perinatal disorders
deciphering nongenetic determinants and targetability of cancer cell plasticity

introductioncancer cell plasticity the ability of cancer cells to change their identity enables tumors to adapt to hostile environments aiding metastasis and resistance to treatments hence plasticity is a major unsolved problem frustrating effective treatment unraveling the mechanisms underlying cancer cell plasticity is crucial to establish new avenues for cancer therapy in contrast to adult cancers many pediatric tumors are driven by a single genetic alteration that fuels their aggressive nature through remarkable plasticity despite their differences pediatric cancers offer a unique platform to investigate cancer cell plasticity due to their genetically clear characteristics i hypothesize that plasticity can be reversed to differentiate tumor cells and mature cancer goalbuilding upon previous ercstg funding we have successfully utilized organoid technology singlecell genomics and lineage tracing approaches to uncover the origins of various pediatric cancers our findings revealed that these cancers exhibit robust yet pharmacologically reversible plasticity at the level of the epigenome the goal of this proposal is to reverse cell state changes during tumorigenesis to mature cancer approachwe will i apply advanced spatial singlecell transcriptomics and epigenomics approaches to a unique cohort of pediatric tumors and metastases to map out cell state changes during disease progression ii utilize our unique pediatric cancer organoids to interrogate and target hierarchical trajectories with the aim to mature cancer and iii screen the enhancerome to identify nongenetic determinants of cancer cell plasticity innovationintegrating these cuttingedge technologies on patientderived tissues and organoids will uncover fundamental principles governing cancer cell plasticity the research will pioneer innovative methodologies and reveal strategies for identifying cancer maturation targets advancing cancer therapy research
data and market power in the digital economy

improvements in technology are enabling firms to collect and process increasingly large amounts of detailed information about their customers and their competitors this growing use of data is fundamentally changing the nature of competition for example it is affecting i how firms compete as they offer collections of services ii the level at which firms compete as they make personalised offers to individual consumers and iii the complexity of firms strategies as they increasingly delegate decisions to algorithmsthe research in this proposal will deepen our understanding of how data is changing market power and how this should be reflected in antitrust and competition policy there are four key themes1 ecosystems many online services are grouped together in ecosystems these services interoperate with each other and share data the research will examine how data affects the boundaries of ecosystems it will also analyse the welfare implications of policies that limit how ecosystems can use data2 personalisation data can be used to give consumers a personalised experience the research will look at how the ability to offer personalised products changes competition and efforts to acquire data the research will also examine how personalisation affects the incentives to engage in anticompetitive practices like predation3 consumer search consumers often need to search in order to learn about firms product offerings the research will explore how a consumers search behaviour generates data it will also examine a firms incentive to manipulate the search process in order to learn more about a consumers preferences4 algorithms data is a crucial input into algorithms the research will examine whether platform algorithms can use certain types of data to prevent sellers from charging less on other sales channels the research will also investigate whether seller algorithms can autonomously learn anticompetitive behaviours like predation
betalactamase inhibitors synthesised through in situ click chemistry

herein kineticguided target synthesis ktgs will be used to discover novel boronic acids inhibitors of kpc2 a clinically relevant serine betalactamase with the aim to tackle antimicrobial resistance amr and restore betalactams antibiotic activity boronic acids transition state inhibitors batsis have been extensively employed to inhibit betalactamases a class of bacterial enzymes responsible for the most widespread mechanism of amr against betalactam antibiotics however the structural variety characterizing the different types of betalactamases imposes the development of novel betalactamases inhibitors blis to fully exploit the potential of batsis as antibacterial agents and expedite the drug development process ktgs will be used as a platform for drug discovery ktgs is an innovative strategy where the biological target is employed to catalyze the synthesis of its own best effective inhibitors from a library of reagents triazolebased batsis which have been reported to be potent and selective inhibitors of kpc2 will be generated in a rapid and efficient way through ktgs in situ click chemistry given the strong interaction between batsis and their targets kpc2 will be employed as scaffold for the formation of potent and selective 14disubstitued triazolebased batsis starting from azido boronic acid warheads and functionalized alkynes in summary this proposal seeks the development of novel blis drug candidates through the accomplishment of three objectives 1 investigation of kpc2 as scaffold for in situ click chemistry and evaluation of the ability to generate triazolebased batsi 2 discovery of novel inhibitors for kpc2 using ktgs 3 identification of at least one highly active batsi against clinically relevant betalactamases to be tested in vivo to accomplish these specific objectives the project will be divided in three main work packages which will involve a combination of biological chemical and analytical skills
southern indian ocean climate evolution and its global linkages

ipcc rcp projections indicate that earths temperature will increase by 15c by 2100 mainly in response to increasing anthropogenic co2 and ghg emissions warming will particularly affect polar oceans eg southern ocean so that uptake most of the anthropic co2 such unprecedented changes in the so will in return strongly impact oceanatmosphere gas exchange lower co2 uptake sosourced ocean circulation lower nutrient stocks and marine biological productiondiversity lower phytoplankton stocks through highlow latitude teleconnections with strong repercussions on the global economy however rcp scenarios are mainly constrained by observational data that are too short in time to cover the full range of climate variability and thus to confidently forecast climate change in this vein the solink project aims to investigate past oceanic conditions seasurface and deep ocean temperatures ocean circulation nutrient stocks and biological variations phytoplankton productivity and physiological state in warmerthanpresent mean climate states of the pliopleistocene as analogs of future conditions to this goal readily available and wellpreserved sediment cores collected in 2019 in the indian sector of the so will be used innovative quantitative geochemical and elemental investigations will be implemented on the two so dominant phytoplankton groups calcareous coccoliths and siliceous diatoms based on the expertise of the applicant and host respectively at ubx this knowledge is considered high priority by scar ipcc horizon europe and un framework conversion of climate change and it is in line with un decade of ocean science of the sustainable development program the solink project is of clear scientific societal and policy relevance and will provide stakeholders commission for the conservation of antarctic marine living resources ccamlr for example with unique information for comprehensive protection of so biodiversity
boosting the knowledge of the strong interaction from quarkonium an advanced simulation framework and beyond

quarkonium the bound state of a heavy quark pair is central to many aspects of particle and nuclear physics like the hydrogen atom in quantum mechanics the discovery of the first quarkonium jpsi was the first tangible observation that quarks are physical particles it provided the first direct evidence of the strong interaction theory in the subatomic world quantum chromodynamics qcd it is nowadays also understood that quarkonium analogues are important in the new physics search programme at the large hadron collider lhc at cern and in the worldwide dark matter hunt quarkonium is also a powerful probe to conduct rich physics studies consequently quarkonium has been measured by almost all experiments despite its importance the quarkonium production mechanism in qcd remains to be understood which places the theoretical interpretations of quarkonium data on shaky ground the necessary ingredient to resolve the issues is to radically improve the quality and the precision of theoretical predictions the primary goals of boson are to advance quarkonium studies with three objectives 1 pinning down the quarkonium production mechanism 2 advancing the precision of theoretical predictions 3 extracting maximal physics information from quarkonium data to achieve them boson will follow three routes 1 the creation of an automated tool at nexttoleading order for any process involving quarkonia and elementary point particles with interfacing to generalpurpose monte carlo event generators 2 nexttonexttoleading order cross section calculations for inclusive quarkonium processes 3 phenomenological applications to particle nuclear and heavyion physics boson outlines a challenging but feasible programme to advance our knowledge of the field with positive impacts not only on the lhc community but also on physicists working with facilities like rhic at bnl belle2 at kek sps at cern and future highenergy experiments eg eic and fcc
optimal control of solar energy plants

this poc will prove that coalitional model predictive control compc can be implemented on the existing distributed control system dcs of a real commercial solar trough plant 50mw and can significantly increase the amount of solar energy collected and significantly reduce maintenance costs this will be the first time that a compc is implemented in a real plant with so many dynamically interconnected subsystems 90 we have demonstrated that manipulating the loop htf flows is fundamental for maximizing the collected solar energy in trough plants the resulting mpc problem is too difficult to be solved with current control techniques because the number of dynamically coupled systems up to 3200 collectors and 800 manipulated variables in the biggest solar trough plants and the complexity of the collector dynamics nonlinear pdesthe idea of compc is to divide the resulting complex mpc problem into several simpler mpc problems each of the mpc controls a coalition formed by a reduced number of subsystems the coalitions are dynamically formed by clustering loops that can benefit from cooperation by exchanging the allocated oil flow manipulated variable for each loop this is done by using a marketbased clustering mpc strategy in which controllers of collector loops agents may offer and demand heat transfer fluid in a marketartificial neural networks will be used to approximate mpc controllers to decrease the computational load we have shown that these techniques speed up the mpc computation time by a factor of 3000 allowing the implementation of coalitional mpc in the biggest solar trough plantsthe pi has long experience in mpc control of solar energy systems and in the control of commercial solar trough plants having designed implemented and commissioned mpc control systems for 17 commercial solar trough plants a letter of supportintend of the industrial sponsor one of the biggest stakeholders in europe is included
integration of a novel direct air capture and utilisation system for renewable fuel production

the proposed project catalyse will develop and maintain longterm collaborations between europe china south africa and nigeria towards renewable dimethyl ether dme fuel production from co2 this objective will be achieved through joint research in new process systems and material development in direct air capture dac and utilisation this requires skills and knowledge in experimental study process modelling analysis and optimisation computational material design and catalysis which will be strengthened by the individual mobility of researchers between europe and the participating countries there are 14 partners involved in catalyse who are worldleading in their respective areas of which there are 3 industrial partners catalyse will start in january 2025 for 48 months there will be 25 experienced and 32 earlystage researchers to participate in 330 personmonth exchange visits a total of 152m funding is requested to support the planned exchange activities the european partners are experts in process modelling and optimisation process intensification computational material design catalysis and co2 utilisation while the chinese partners are experts in process intensification green hydrogen production and dac the south african partners are experts in dac and sustainability assessments while the nigeria partners are experts in renewable energy and green hydrogen production knowledge transfer and training will take place through the planned secondments we will generate at least 30 journal publications and 30 conference papers in addition 2 special issues will be published in leading journals such as applied energy 2 workshops and 2 special sessions at major international conferences will be organised to disseminate project results