Dragon09/odtu_chatbot huggingface dataset:
discovery of new frontal temporal dementia multimodal spectral markers in biofluids

the central aim of the project is to apply multimodal spectroscopy combined with machine learning to identify a fingerprint for frontal temporal dementia ftd and alzheimers disease ad in saliva and plasma ftd is the second most common dementia and usually affects individuals younger than 60 years old ftd is difficult to diagnose since there is no single exam that determines the disease but instead many costly or painful exams that together link the disease some of the symptoms of the disease may be confounding with others such as ad while the usual search for biomarkers focuses on individual patterns the present proposal is to use a holistic approach vibrational spectroscopy provides a snapshot of the entire chemical finger print in a labelfree way in this project samples from ftd ad and healthy subjects of 45 years old will be analysed using raman mid and near infrared spectroscopy monash university in australia and complemented with mass spectrometry on the same samples icgeb in italy advanced machine learning tools provide a powerful approach for data analysis unravelling hidden trends correlations and also identify the main contributions that characterize the type of sample the spectra recorded using the extended wavelength range encompassing the midinfrared and nearinfrared spectral regions will be processed with stateoftheart machine learning tools to identify the molecular phenotype and establish markers in patients with tdp and ad these findings will pave the way to the development of a new screening tool that would decrease the costs associated with the current diagnosis of ftd and in general for neurodegenerative disorders
curing eu aquaculture by cocreating health and welfare innovations

farmed seafood is an important source of protein for food and feeds with a lowcarbon footprint which has an important role to play in helping to build a sustainable food system a strategic and longterm approach for the sustainable growth of a resilient eu aquaculture is therefore more relevant today than ever however the efficient and costeffective control of pathogens remains among the main challenges for the sector particularly relevant for europe where there is a great variety of species and production systems which hinders the implementation of good husbandry practices tailored to each aquatic species through active engagement with key stakeholders cure4aqua aims to jointly improve the resilience of eu aquaculture under environmental biological and socioeconomic stress by improving aquatic animal health and welfare and supporting the environmentally friendly inclusive safe and healthy production of seafood cure4aqua will do so by 1 developing costeffective vaccines to prevent disease caused by 5 pathogens of economic significance to eu aquaculture 2 identifying markers with diagnostic capacity to be integrated to selective breeding programs to improve stress and disease management 3 developing innovative biobased and sustainable solutions as an alternative to antibiotics for controlling fish pathogens at various life stages and alleviate the pressure of global antimicrobial resistance 4 developing new tools and technology to improve health and welfare monitoring at the fish farm level and diagnostics of fish pathogens both at the laboratory and the fish farm levels 5 placing fish welfare at the foreground of aquaculture production through the development of high welfare standards that consider different lifestages production systems and knowledge of welfare needs and 6 ensuring effective external communication dissemination and exploitation of project activities and results to all relevant target groups
integrated development platform for customer and aggregator energy management systems

independent aims to overcome the main obstacles for largescale adoption of flexibility services in buildings and industry by providing an integrated development and operations platform idop for standardcompliant customer energy management systems cems and aggregator energy management systems aems idop will be interoperable with over 40 energy management systems and 60 smart appliance vendors and cover 90 of the flexibility in buildings and industrial sitesidop will help to reduce energy costs and co2 emissions by providing open interfaces innovative ai and optimisation solutions for flexible resource modelling optimal control multimarket operation and the automated integration of legacy systems simultaneously idop will significantly reduce the development deployment and operational expenses thereby establishing dsfm as a sustainable business on a large scale idop commits to full compliance with the dsfm standards including the en 5049112 and iec 62746 standard families and the saref ontology additionally idop introduces gaiaxcompatible data spaces to govern data in buildings and industrial sitesthe project brings together 14 partners including four aggregators seven ems service companies and two major home appliance manufacturers that will adopt idopbased solutions into their offerings the idopbased cems and aems will be demonstrated and qualified in largescale pilots in four countries a total of 14 mwh flexibility capacity will be harnessed from buildings and industrial sites and connected to eight operational energy wholesale tso and dso flexibility markets to demonstrate the cems and aems at trl 8 the idop solutions will enable the energy transition by reducing ghg emissions by 19 million tons a year for all customers in 610 years the solutions provide also significant monetary benefits 15 roi and 36 billion eur cost reductions a year compared to the situation without any dsfm solution
full qualification in france of largescale hydrogen underground storage and replication from germany to all european countries

if the solution for integration of intermittent renewable sources to decarbonate the industry and mobility is hydrogen for example with european hydrogen backbone initiative largescale storage of h2 technical feasibility and economic viability is still hampering wide eu market uptakefrhyge main goal is to demonstrate and qualify in industrial environment in france the injection and withdrawal of h2 in a current natural gas commercial storage site but frhyge will also deliver the conversion process and upscale strategies to foster eu replication of h2 storage in caverns starting with an ongoing project in germany to accelerate knowhow transfer and economic viabilityfrhyge objectives are to develop and implement two conversion processes from natural gas or brine cavern to hydrogen storageto demonstrate h2 storage and cyclability in a 3000 tons potential cavern with 100 cycles from 1h to 1 weekto study the local hydrogen value chain and the technoeconomic impacts on local actors and to upscale and deploy h2 storage along european hydrogen backbone to assess the risks and environmental impacts of h2 cyclic storage in salt caverns and provide guidelines for safety regulation and normative adaptations in europefrhyge will open a path towards a potential of commercial 38 ktons of h2 storage in several eu countries as soon as 2030 and up to 15 mtons in 2050 through conversion and creation of caverns leading to a capex below 10 kg of h2 storedto succeed frhyge gathers eu leading h2 industries and research centres led by worldwide underground storage actor storengy willing to make happen largescale and multisite h2 storage in caverns
the emergence of global nongovernmental spaces in education nongovernmental organizations and the global turn in education

about 30 per cent of the worlds population are children children are not only the most important people for their parents but also the future of our societies providing them with the best possible education is of inestimable importance which education is best however is a question that is continually being negotiated for a long time this question was answered primarily by national governments for some years however ongoing processes of globalisation are significantly shaping education leading to what scholars term the global turn in education nongovernmental organisations ngos have become core actors in this global turnaround they are increasingly joining forces in educationrelated transnational networks ie global nongovernmental spaces that express an obvious claim to influence schools and education systems worldwide hence questions arise about the associated risks and benefits for schools particularly with regard to educations role in promoting educational achievement and equal opportunity among students from different backgrounds however despite this increasing relevance scholars have neglected to investigate transnational networks of ngos in the field of education emerged aims to drastically improve scientific knowledge on ngos in education by analysing the emergence of global nongovernmental spaces in education and how they influence education systems and schools a contribution from which a farreaching scientific and in the long run societal impact is to be expected it will do so by developing an interdisciplinary methodology integrating inferential social network analysis sna and discourse network analysis dna alongside qualitative data analysis based on grounded theory to contribute to further theory building this methodology is highly innovative as it draws theories and methods from different disciplines together in novel ways and thus follows an approach at and beyond the frontiers of disciplines
networks and the rule of law uncovering socioeconomic outcomes

netrol networks and the rule of law uncovering socioeconomic outcomes is an innovative multidisciplinary collaborative research project of institutions from 8 countries austria czechia france germany italy netherlands north macedonia poland and scholars from different disciplines and subdisciplines economics law political science network science netrol develops a conceptual framework theorizing the positive or negative role of networks impacting rule of law and socioeconomic outcomes it generates largescale historical and contemporary datasets relevant to the study of rule of law on values and social norms legislation public spending and personal connections judicial governance and decisionmaking the approach to rule of law emphasizes the role of citizens exploring networked coordination as a mechanism to halt weakening of rule of law building on eus definition of rule of law netrol analyzes networks in lawmaking executive decisionmaking and the judiciary for the judiciary netrol maps the interaction of rule of law and concentration of powers analyzing the effect on formal and informal judicial and prosecutorial independence using stateoftheart data techniques such as causal machine learning and multilayer network analysis the project generates original knowledge on causes of rule of law weakening and the impact on socioeconomic outcomes such as growth inequality and trustthe projects innovative character stems from the broad and multidisciplinary perspective on rule of law the integration of different approaches studying the impact of networks on public goods the gathering and analysis of new actionable datasets the use of innovative data science econometric network and text analysis techniques the exploration of the conditions under which citizens defend the rule of law the design of interventions supporting rule of law based on experimental data and input from stakeholders
introducing deuterium for next generation chemical biology probes and direct imaging

the ideal microscopy experiment would take place in native cells without genetic engineering with 3dimensional resolution on the single molecule scale 10 nm by observing the endogenous molecule itself i propose the introduction and use of deuterium deuteron as a general method for a multimodal approach to i synthesize a firstinclass deuterated cyanine cy fluorophore for superresolution imaging ii to design and test deuterated nextlevel photoswitches to restore vision and iii use these probes and deuterated drugs for direct and bioorthogonal spectroscopic imaging in particular deuterated cys will allow stochastic reconstruction microscopy storm by using near infrared light to break new ground in protein localization in live tissue opening the gates for thick sample imaging 100 m axial with retained superresolution 20 nm in addition deuterated azobenzene photoswitches will be designed to finally reach the indispensable and todate unobtained light sensitivity to remote control neural signalling in vivo lastly the use of labelfree labelling and imaging will be explored with deuterated drugs to observe drug uptake and metabolism by utilizing the unique properties of the carbondeuterium bond in raman spectroscopy coupled to a confocal microscope deuterated drugs will be tracked in native and live cells without any genetic engineering strategies and on the molecule of interest itself reducing perturbations and artefacts to a minimum this groundbreaking approach holds promise to be generalizable to chemical biology disciplines and as an unconventional yet attractive and powerful method to design and synthesize next generation small molecule probes developing a pipeline for these aims will be a game changer with ramifications for the life sciences cell biology drug development and with prospective translational impact
planktonlike protocells for artificial photosynthesis targeting carbonneutral energy vectors

while mature solar technologies ie photovoltaics photoelectrochemical cells cannot simultaneously address the multifaceted future energy challenge plankton aims to develop a disruptive netzero emissions technology to both address the global energy demand and reoxygenation of our planet inspired by nature we propose to assemble the first synthetic planktonlike protocells that autonomously utilise light water and co2 to produce o2 and formate as a green h2 vector to this aim the planktonlike protocells will be shaped as containers of two synergic subdomains mimicking the natural plastids and the co2enzyme organelles the artificial plastid 1st type protoorganelle will utilise light to oxidise h2o to o2 and reduce a methyl viologen mv cofactor this latter will feed the co2rich protoorganelle to selectively produce formate by a cascade enzymatic reaction we are expecting that this original bioinspired strategy will open a route to sustainable solar hydrogenthe long term impact is envisaged for scientific innovation in groundbreaking solartechnology going beyond the conventional photoelectrochemical cabled asset and readily exploitable for empowering the eu vision for smart buildings as microenergy hubs in the world fundamental research advances will be monitored by plankton innovation radar activities protected by our ip policy and disseminated to reach the expected stakeholders and the general publicmultidisciplinary collaboration among the 6 partners from 4 eu countries 5 research centres and 1 technologybased company underpins the project activities that will target the eu mission plankton counts on the valuable experience of its scientific advisory committee where international renowned scientists from princeton usa berkeley usa tokyo japan and epfllausanne switzerland will contribute to the results evaluation and benchmarking in the field of light management photocatalysis and green h2 transport
digitafrica towards a comprehensive panafrican research infrastructure in digital sciences

the african unions science technology and innovation strategy for africa stisa2024 positions science technology and innovation as fundamental drivers of africas socioeconomic development and growth it emphasizes the need to strengthen three main pillars 1 buildingupgrading research infrastructures ri 2 enhancing professional and technical competencies and 3 promoting entrepreneurship and innovation it also highlights the importance of fostering collaboration among african countries and establishing partnerships with international stakeholdersict information and communication technologies is identified as a critical priority sector areas such as computer science telecommunications cloud computing big data artificial intelligence machine learning security and iot offer potential for creating new knowledge research capacities and industries that address african and global challengesdigitafrica aims to lay the foundations of a panafrican comprehensive ri in digital sciences which will have a transformative impact on aueu shared ri as well as innovative education and training digitafrica will prepare the transformation of this partnership into a sustained research initiative in common strategic fieldsdrawing from the expertise of partners across five au countries each with a strong background and representing diverse african contexts alongside eu partners who coordinate the first two esfri digit ris dedicated to digital sciences digitafrica aims to exchange experiences consult stakeholders and foster dialogue to collaboratively develop a strategic approachdigitafrica will serve as a catalyst for realizing the vision of a panafrican digital ri and should become a cornerstone of euroafrican cooperation in ri the impact of digitafrica will contribute to digitally transforming the african continent for prosperity and inclusivity and to move with europe towards a shared twin green and digital transition agenda
hybrid cyber warfare and common security in europe

the proposed project will address the hybridization of modern warfare which has led to a multidimensional crisis both in europe and worldwide after russias invasion of ukraine on 24 february 2022 because these recent developments blur the dividing line between war and peace the project will focus on cyber warfare as a key component of multilayered hybrid strategies employed by hostile state actors and organized criminality to undermine peace and security in europe building upon the european heritage of partnerships the main objective of this research is to develop an exemplary model of effective legal and cyber measures that can become a foundation for a common principled approach to digitalsecurity and fundamental freedoms in eurasian countries with varying political social and economic settings aimed not only at eu member states but also at other countries which seek closer cooperation with the european union the research methodology will use an interdisciplinary approach at the intersection of cyber security and law to contribute to activities that can prevent malevolent hybrid strategies from prevailing and setting an undesirable precedent for future warfare campaigns as opposed to the predominant focus on economic labour and social dimensions of new technologies this novel research considers the implications of progress in terms of issues related to technological sovereignty safety of critical infrastructure and joint defence capabilities my integration in the interdisciplinary group on crime control and security law at uit the arctic university of norway will be instrumental in complementing my knowledge of europeaninternational law and transitional justice with the latest cyber security expertise transferring it to ukraine and other eu partner countries as well as reaching a professorship to train next generations of experts whose intersectoral cooperation will lay the ground for a coordinated response to hybrid warfare in europe
mainstreaming socialecological sufficiency closing the sustainable consumption gap between societal demand and ecological limits

mainstreaming socialecological sufficiency closing the sustainable consumption gap between societal demand and ecological limitsglobal patterns of production and consumption are fundamentally unsustainable threatening key planetary boundariesearth system processes vital for maintaining of ecological integrity and human wellbeing strategies for averting this ecological overshoot have largely focused on greening production by reducing the material intensity efficiency or the material throughput consistency of economic activity however neither of these approaches address what constitutes a sustainable scale of economic activity here the novel notion of socialecological sufficiencya socially satisfactory standard of living within ecologically sustainable natural resource usagerepresents a vital third integrative strategy for moving towards an economy within a safe operating space for humanitythe overall aim of mases is to mainstream the notion of socialecological sufficiency as a conceptual and empirical bridge between research on planetary boundaries and sustainable production and consumption with farreaching academic and societal implications for sustainable resource use wp1 will synthesize disparate approaches to conceptualizing sufficiency and cement socialecological sufficiency as a core idea in sustainability wp2 will employ a global environmentally extended material and energy flow analysis to quantify key planetary boundaries landsystem change biochemical flows climate change and freshwater use in terms of ecologically sufficient levels of household consumption wp3 will adapt methods from consensual deprivation assessments to identify socially sufficient levels of household consumption across different social groups wp4 will assess the feasibility of different strategies for closing the gap between ecologically safe and socially acceptable levels of household consumption wp5 addresses project management
epigenetic profiling of menstrual blood for precision cancer detection and prevention

cancer has overtaken cardiovascular disease as the number one cause of mortality in high income countries cancer incidence is increasing across the globe morbidity and mortality from womens cancers particularly breast ovarian and endometrial cancers follow or exceed these general trends in cancer incidence tackling this growing cancer burden requires a multifactorial approach including understanding the fundamental drivers of cancer development improving methods for detecting earlier those forms of cancer with the worst prognosis predicting a persons risk of developing cancer and identifying appropriate targets for preventing cancer indeed one of the biggest obstacles in identifying tailored cancer prevention strategies is a lack of surrogate readout markers reflecting and integrating an individuals response to the cancerinitiating and cancerpromoting factors that they are exposed to during their lifetime our research delivers novel epigenetic tests relating to each of these key areas with an emphasis on womens cancers and those who are at an increase risk for cancer due to their underlying genetics such as women with brca1 or brca2 mutations and women with lynch syndrome central to the discovery and development of the epigenetic tests is a cellular deconvolution algorithm that is used to calculate the proportions of cell types within complex mixed samples such as cervical swabs in order to broaden the clinical utility of the tests and explore new applications refinement and expansion of this cellular deconvolution algorithm is now required the expansion will include cell types in menstrual blood which is an important and understudied clinical sample type the epiprecise project will deliver this refined and expanded algorithm and apply it to a test case in an area of high unmet clinical need the refined algorithm will then be applied across the research portfolio and shared