Dragon09/odtu_chatbot huggingface dataset:
first in class lateral meniscus prothesis to relieve pain and restore mobility for koa patients

atro medical developed a revolutionary prothesis that quickly relieves pain and restores mobility for severe koa patients with a dysfunctional lateral meniscus trammpolin we offer a minimally invasive low impact procedure that postpones undesirable tkr and reduces koarelated healthcare costs and medication dependency while restoring full knee functioning our innovation is composed of a dual highly biocompatible polymer that carries the body weight and is uniquely shaped to reproduce the anatomical shape and mechanical properties of the native meniscus the technology has proven itself for the medial meniscus and received the breakthrough device designation of the us fda in 2020 for successful market entry of our lateral trammpolin in 2026 we aim to finalize our preclinical activities conduct a fihstudy and obtain cemarking in parallel we will perform a health economics analysis as a crucial step towards obtaining reimbursement for large scale uptake in the medical system
smart integration of process systems engineering machine learning for improved process safety in process industries

prosafe proposes a novel doctoral training program in the multidisciplinary field combining machine learning artificial intelligence and process systems engineering with domain knowledge of process industry and process safety prosafe will pioneer new foundations by integrating quantitative risk assessment process systems engineering pse with interpretable machine learning ml and artificial intelligence ai disciplines as targeted breakthroughs to achieve the objectives to this end prosafe will develop new synergistic tools and train skilled professionals to address this very important societal economic and environmental challenge of safe and sustainable process industries prosafe research objectives are1 harmonize robust qra methods and implementation strategies for effective and improved risk assessment and process safety 2 develop ai and ml interpretable ml models using domain knowledge for efficient safe and reliable operations 3 develop synergistic integration of modelbased with databased methods for improved process safety operation and monitoring 4 demonstration and validation of prosafe novel concepts and methods on industrial relevant case studies for safer operationprosafes major training objectives are1 training of doctoral candidates dcs through individual projects combining multidisciplinary competences in the areas of ai ml and pse within the domain of process safety2 establish and pilot the concept of a truly interdisciplinary european multicenter training program in aiml qra and pse within the domain of safety in process industries through relevant networkwide events courses workshops and onsite industry training that complements training in soft skills for effective communication and entrepreneurshipthrough this research and training program prosafe will contribute to realizing the promising potential of the new artificial intelligence paradigm with a particular focus on process safety in process industries
heron center of excellence in robotics

this project aims to create the first robotics center of excellence coe in greece for advancing the science and technology of robotics in the ai era coupled with industrial innovation the new coe named heron hellenic robotics center will be a team effort between the athena research center an excellent team of greek university professors the italian institute of technology and the karlsruhe institute of technology heron will be driven by excellence and pursue world class research in areas that reflect current and emerging challenges of national and eu value covering a broad spectrum of ri directions empowered by ai 1 safetysecurity including aerial ground and marine robotics 2 field robotics including agriculture maritime logistics and space 3 healthcare including mobility and cognitive assistance of motorimpaired and elderly people surgical and socially assistive robotics heron will build makerspaces and joint labs to support validation research demonstration education and maker training throughout greece and beyond it will initiate and coordinate actions to mobilise and collaborate with the greek robotics ecosystem emphasizing strategic collaborations between academia and industry towards innovation across the entire robotics value chain such actions backed by the compelling background experience and synergy between the partners and the multidisciplinary heron team provide a unique prospect to establish a sustainable robotics coe in greece which can transform the greek ecosystem with major benefits to the economy and social wellbeing the proposal is strongly supported by the greek government with matching funds and by over 70 public and private sector entities industry universities research centers clusters regions from greece europe usa and the greek diaspora via endorsement letters and significant complementary funding or inkind support ensuring herons longterm sustainability beyond the project end
connected and adaptive maintenance for safer urban and secondary roads

the connected and adaptive maintenance for safer urban and secondary roads project camber aims to develop and demonstrate improved safety monitoring across urban and secondary rural road networks through realtime data feedback into road maintenance systems and proven lowcost interventions performance metrics based on newgeneration data sources will provide road managers uptodate information on safety issues damage and routine maintenance and upgrade needs data collated from a range of sources such as telematics vehicle and smartphone sensors and road user feedback will feed into safety assessment models to flag what measures are required to ensure a safe road environment for all road users including roaduser minority groups with varying design needs such as powered twowheelers ptw camber will support this through muchneed research and testing of lowcost road safety interventions and lowimpact maintenance techniques including those for vehicles with advanced driverassistance systems adas the approaches will be demonstrated on urban and road networks in five european countries cambers economicallysound solutions and new knowledge will be communicated through established networks to european road managers policymakers and industry to support the decisionmaking and investment needed for more efficient maintenance for safer urban and secondary roads
digital autonomous intelligent and synchronous system for continuous identification optimization and value extraction of resources from the endofuse built environment

discover aims to develop an autonomous synchronous continuous and intelligent identification and data analysis system for materials and products in existing endoflife built works the proposed approach will provide key stakeholders including academia research performers along with construction industry representatives with datadriven insights to make deconstruction more efficient optimise the use of resources improve the environmental footprints and enhance the circularity of construction and demolition unlocking the potential of endoflife built works which will become material banks the expected outcomes include an autonomous robotic platform coupled with continuous identification tools to scan built works and provide synchronous quantitative and qualitative data from different materials including complex and concealed elements artificial intelligence algorithms will allow a rapid analysis of the properties and characteristics of components and feed the automated scantobim model creation the multidimensional bim including selective demolition processes labour productivity and technical planning will become a digital twin of the demolition site optimised by social economic and environmental multicriteria assessments this approach will highly contribute to significantly increasing the supply of traceable and sustainable construction materials and products for enhancing their wider market acceptance following the waste hierarchy the social impacts of digital transformation in the construction sector will be considered and also new professional development tools for the relevant stakeholders will be proposed the system will be tested in 4 different real demolition sites spain portugal poland and belgium offering a complete range of built work typologies and wide geographical coverage to demonstrate the replicability potential of discover increasing the project dissemination capacity and awareness among the construction sector
efficient selective ion pumps based on ratchet mechanisms

i propose a novel membranelike device that utilizes a ratchet mechanism to drive ions selectively up a concentration gradient this device can serve as a building block for an efficient ion selective separations technologyion selective separation with membranebased processes may advance dramatically technologies for water treatment resource extraction from sea water ion specific sensors and many other applications moreover since about 1015 of the global energy consumption is used for chemical separations a high efficiency membranebased ion separation processes can reduce greenhouse gas emissions significantly however membranebased ion selective separation is a longstanding unmet challenge in science and engineering although conventional membranebased separation is extremely efficient in unselective separation processes such as reverse osmosis water desalination membranebased processes showed limited success in ion specific separations furthermore the need for a molecular level control of the membrane properties limits the scalability of most of the membranebased ion selective separation techniques that are currently being studiedour proposed device the ratchetbased ion pump is driven with a ratchet mechanism which utilizes modulations of a spatially asymmetric electric field to induce a nonzero net ion flux up a concentration gradient we will utilize a fundamental ratchet process in which the ratchet input signal drives particles with the same charge but different transport properties in opposite directions to design highly selective fittopurpose and realtime controlled ion separation systems thereby bypassing the limitations faced by current technologiesin this research we will combine theory simulation and experiment to improve our understanding of the ratchet mechanism design and optimize ratchet based ion pumps demonstrate ion selective ratchetbased separation systems and set their thermodynamic performance limits
stage from stage to data the digital turn of contemporary performing arts historiography

digital sources are one of the most significant challenges facing performing arts historiography at the intersection of history epistemology and digital humanities stages key goal is to move performing arts studies into a digital context to establish a new historiography of mise en scne and their creative processes in europe since wwii it proposes a groundbreaking theoretical and methodological framework merging culture analytics actornetwork theory data modeling and computer vision to challenge conventional approaches to the paradigm shift of digital traces in performing arts studies i call this new field performing arts analytics stage will allow a copernican revolution of our methodologies combining close reading with distant reading and distant viewing hypothesisdriven with datadriven analysis hermeneutics with artificial intelligence computer vision and digital humanities qualitative interpretation with quantitative evidence stage will build from the avignon festival collection before opening to larger corpora to scale up our results and expand our analysis through the two prisms of influence and collaboration stage will reveal creation contexts and networks aesthetic influences and creative process models in an unprecedented way it will make it possible to test new algorithms for mediumsized corpora to develop a new approach to studying collaborations over time through digital traces to demonstrate the potential of a datadriven approach and interdisciplinary research in humanities to create accessible corpora for future research to demonstrate the importance of digital traces for cultural heritage and research projects stage is transferable in that it will create widely open science tools methodologies and theoretical frameworks it will be of value to historians and art historians who explore digital traces of the past promising a potential impact beyond performing arts studies
decoding consequences of complex chromosomal aberrations by multimodal singlecell deconstruction to overcome treatmentresistance cancer

how does a cell with unstable complex genomic rearrangements stay alive and even give rise to aggressive highly resistant malignancies this question remains an ultimate research challenge for cancers with highly aberrant genomes such as acute myeloid leukemia with complex karyotype ckaml its etiology timeresolved clonal dynamics molecular heterogeneity and treatment resistance mechanisms are still largely elusive in particular the genetic and nongenetic dynamics that drive cancer progression under treatment are elusive to current technologies and escape singlecell resolution shatteraml will tackle the genomic enigma of ckaml by analyzing longitudinally obtained triplicate diagnosis treated relapse samples to examine intrapatient genetic and nongenetic heterogeneity using scnovacite a newly developed multimodal singlecell omics approach this approach combines i structural variation discovery with nucleosome occupancy and cisregulatory element accessibility profiling scnova with ii cellular indexing of transcriptomes and epitome sequencing citeseq we will uncover multilevel disease dynamics at singlecell and subclonal levels along the disease course providing a blueprint for studies of other structurally instable cancers identified molecular insights into the networks mediating therapy resistance leukemic stem cell activity and immune escape will be further explored functionally in patientderived in vivo models pharmacological interference and crispri are used to engineer deregulated signaling pathways for precision oncology and crispra screens are applied to sensitize ckaml stem cells to natural killer cellmediated elimination shatteraml will fundamentally transform our understanding of the impact of clonal evolutionary dynamics of malignancies triggered by aberrant genomes and aims to develop novel preclinical strategies to combat ckaml resistance via immunological and precision oncology approaches
electrochemical synthesis of polycyclic aromatic hydrocarbonbased films for advanced sodiumion battery anodes

the project pahssib aims to advance binderfree anode development for battery current collectors focusing on sustainable sodiumion batteries sibs it seeks to overcome challenges in sib anodes by using polycyclic aromatic hydrocarbons pahs via pulse reverse electrodeposition pre the project has four main goals 1 develop a scalable pre method for stable pahbased films with a yield exceeding 90 2 customize film properties for optimal na storage 3 enhance hierarchical pah film porosity with asphaltene and 4 investigate pahbased films as binderfree sib anodes and prototyping as a proofofconcept pahssib responds to the need for alternative energy storage due to limited li resources ethical concerns and safety issues in libs sibs powered by abundant na resources offer a responsible solution but require improved electrode materials various materials have been explored including metal alloysoxidessulphides and carbonbased materials janus nanographenes show promise but face properties and synthesis challenges hard carbons are crucial anode materials but their microstructure design remains unclear the project also addresses solid electrolyte interphase formation to enhance sib performancepahssib combines synthetic techniques to control pahbased anode growth overcoming the problems mentioned scalable electrochemical techniques and asphaltene waste materials are used to create porous hierarchical pahbased anodes it comprises four research work packages 1 finetuning the pre method 2 designing nonplanar pahsbased films 3 creating hierarchical pahsbased films from asphaltene 4 integrating pahsbased anodes into sib cell prototypes and evaluating performance in summary pahssib addresses challenges in energy storage by developing advanced binderfree sib anodes and utilizing innovative methods and materials for improved performance prototype cell 250 mahg 5000 cycles scalability and sustainability in sibs
developing a rating tool for app safety appsafe

this project aims to develop a new approach for rating mental health apps taking into account the subjective needs of users in the mental health community in particular our aims are to show that 1 an automatic rating of safety in relation to mental health apps is possible and 2 such an automatic rating system can take into account subjective needs of app users our goal is to build a prototype of an automatic rating system for affective safety while also demonstrating the limitations of what cannot be automated in such a rating system the covid19 pandemic has driven demand for apps as key tools either mandatory or voluntary in nature for responding to social and scientific challenges including both mental health and public health in general yet we have not updated app regulation standards or rating procedures for a world where apps are often mandatory and where people in a situation of vulnerability increasingly use apps based on business models originaging in the commercial sphere this scaling up and the public concern over health apps during the pandemic have created an explicit need for the definition and rating of apps with regard to affective user safety this project aims to contribute to giving apps a sounder basis in standards and regulatory clarity and in turn to make informed trust in apps more possible
manipulation of photoinduced processes by reshaping transition states via transient strong coupling

photochemistry deals with the lightassisted transformation of molecules into useful products these processes are routinely manipulated by chemical modification and external laser driving femtosecond coherent control uses ultrashort pulses to initiate and actively modulate a chemical reaction however successful control of efficiency and specificity of a chemical process is still awaitedulysses proposes a radical departure from the way chemical processes are currently controlled by light i will introduce an innovative transient polaritonic control for manipulation of photoinduced processes using polaritons hybrid lightmatter states in strong coupling regime activated on demand in optical nanocavities i will exploit tunable resonances in metasurfaces nanostructure arrays excited by ultrashort pulses for controlling the energy landscape of molecules reconfigurable molecularmetasurface metacavities will switch onoff strong coupling for realtime selective reshaping of transition states that i will apply to the proofofprinciple control of a photoisomerization reactionthe project proposes a paradigmshift in coherent control through three objectives combining physical chemistry with ultrafast nanophotonics which perfectly suit my scientific profile1 develop a novel multidimensional kd spectroscopy for characterizing fundamental processes in strongly coupled systems with the unprecedented combination of temporal and momentum resolutions2 design and characterize reconfigurable metasurfaces with ultrafast alloptical tuning of resonances to enable transient strong coupling3 demonstrate the manipulation of the energy landscape of a photoisomerization by reshaping the transition states via transient strong coupling in a metacavityi foresee my unique approach will transform chemical control by enabling realtime manipulation of the desired reaction pathways with potential for quantum chemistry remote control siteselectivity catalysis
european labour markets under pressure new knowledge on pathways to include persons in vulnerable situations

paths2include will provide new gendersensitive comparative knowledgebase on effective employment policies targeted at developing inclusive labour markets for persons in vulnerable situations in europe the study will examine the importance of intersectionality related to how context creates vulnerability by focusing on three central labourmarket processes recruitment career trajectories and work exit through the involvement of national and european stakeholders paths2include aims to develop proposals for effective policies and to inform relevant policymakers with a view to maximising the projects impact from a societal as well as scientific perspective the project will combine diverse methods data and disciplines economics political science and sociology in innovative ways 1 harmonised factorial survey experiment combined with qualitative interview studies with employers in four european countries de no pl and ro 2 causal analyses of comparative microdata 3 microsimulation analysis exploiting the euromod infrastructure linking the analyses of these data and the three central labourmarket processes will give original insights on how institutional and contextual factors shape barriers or mitigate risk of labourmarket attachment among persons in vulnerable situations these insights could include crossnational differences in employmentprotection legislations and facilitation of care regional differences in demand for labour differences at company level related to the size of the firm flexibilities in job tasks and conditions that were affected by the covid19 pandemic covering unemployment rates and infectioncontrol measures across different segments of the labour market the project will be implemented by an interdisciplinary consortium of seven research institutions and one european civil society organisation the consortium has a balanced composition in terms of gender stage of the career and area of expertise
reducing myopia progression with red light therapy treatment mechanisms and safety levels

myopia shortsightedness represents a mismatch between the eyes length and its dioptric system refracting power which results in distant fixated objects being imaged in front of the retina the underlying problem is typically excessive eye elongation multiplying the risk of sightthreatening eye diseases faced with rapidly increasing myopia prevalence figures worldwide and associated huge economic burdens public health systems need more and improved myopia control in children a recently described controversial method for reducing myopia progression in children is lowlevel redlight therapy lrl with clinical trials reporting significant effects with daily short periods of direct retinal red laser light stimulation however a recent report of retinal damage and reduced vision along with inadequate safety monitoring calls its safety into question myrel addresses open questions regarding the underlying mechanism ocular effects risks and longterm safety of lrl using an established animal guinea pig model of myopia and complimentary studies in humans the interdisciplinary project will allow detailed evaluation of lrlinduced structural and functional changes in myopic guinea pig eyes results from the latter will be used to inform a complimentary human study focused on 3 areas in which choroidal thickness will serve as a biomarker for therapeutic effects 1 the intensitydependent doseresponse effects of lrl limited to established safe intensities 2 shortterm effects of ambient redlight exposure 3 effects of manipulating the spectrum of digital device screens plausible outcomes of these novel studies include a prototype for hazardfree lrl as well as recommendations on optimal spectral settings for digital devices both aimed at controlling myopia progression in children in these ways myrel will help to prevent severe eye diseases with a significant positive impact on health and economic sectors given eus aging population