Dragon09/odtu_chatbot huggingface dataset:
reflection in warped accretion disks around black holes

black holes are the most extreme and compact objects in the universe since their theoretical prediction scientists have tried to shed light on these objects that swallow everything that comes close to them including light this is a fascinating paradox that poses difficult challenges to study black holes in the universe fortunately these objects leave their traces imposing their extreme gravitational pull on the surrounding matter while it is falling into the black hole the reward project aims to study accreting black holes in order to obtain the most accurate measurements of their two parameters spin and mass such measurements would allow for the first time to reconcile the tension from gravitational waves and xray models and build a coherent picture of black hole phenomenology recently launched xray missions eg nicer nustar have provided unprecedented high signaltonoise energy spectra and fast timing resolution observations which require a new generation of models for their interpretation in order to do it i will combine hydrodynamics simulations with xray models in particular i will model radiation reflected from the accretion disk accounting for the simulated 3d density structure of the disk i will compare these new models with xray observations of accreting black holes and i will provide robust spin and mass measurements of those systems
bioactive reinforcing bioink for hybrid bioprinting of implantable bone

3d bioprinting is an emerging technique that offers promise for fabricating implantable tissues despite significant advancements the field struggles to replicate the mechanical robustness and biological complexity of native tissues particularly in applications requiring high mechanical strength such as bone this proposal introduces bioforceink a bioactive reinforcing bioink designed for direct bioprinting alongside a cellladen hydrogel within a cellconductive environment the microparticlebased bioink is printable at room temperature and solidifies at 37c forming a stiff porous scaffold within the construct our preliminary studies demonstrated its excellent printability mechanical properties and osteoconductive capabilities in a hybrid bioprinting context to enhance vascularized bone differentiation in vitro and support bioprinted implant integration and bone recovery in vivo the bioink will be enriched with osteogenic and vasculogenic factorsthroughout this project we aim to develop the growth factorloaded bioforceink and utilize it for creating vascularized bone implants by hybrid bioprinting in tandem with cellladen soft bioink we will then evaluate the regenerative potential of the bioprinted vascularized bone implants in a criticalsize bone loss model additionally we plan to test the technology with industrial partners and prepare it for commercialization by the end of the project bioforceink offers a unique combination of mechanical support and biological activity that facilitates the singlestep fabrication of physiologically relevant bone implants this innovation has the potential to significantly narrow the gap between bioprinting technology and clinical application contributing to the development of personalized mechanically robust and biologically functional bone implants with its tunable properties bioforceink could be further adapted for bioprinting of various tissues reflecting its broad potential across the field
robotic bioreactors for the longitudinal control of restorative remodelling in the human skeletal muscle

muscle damage impairs vital functions eg movement respiration recovery depends on the longterm interaction between neuromuscular and immune systems if exposed to regimens of electromechanical stimuli damaged muscles can remodel new structural properties over days inflammation at the damage site is initially needed to clear debris but if prolonged as in many neuromuscular disorders it may hamper structural remodelingrehabilitation robots such as exoskeletons and neurostimulators can deliver tunable stimuli to muscles however although they can compensate for lack of eg muscle strength within seconds they cannot control for how muscles remodel across days roboreactor shifts the paradigm to control muscle key inflammation and remodeling factors over large time scales where the knowledge gap is1 i will develop robots that deliver electromechanical stimuli to fibres and innervating spinal neurons in humans across weeks by combining biosignal processing and modeling i will predict how robotstimuli influence key inflammation and remodeling processes in vivo with cellscale resolution2 i will engineer human tissues in vitro and develop robots that can expose tissues to the same stimuli experienced by muscles during robotic training in vivo this will enable modeling subcellular inflammation and remodeling factors with detail not attained in humans3 i will fit subcellular models in vitro and embed them in multiscale models built in vivo this will create new modelbased controllers to demonstrate how robots optimize for inflammation to enhance otherwise hampered remodeling with a focus on neural and muscular dependences in poststroke subjects i propose muscle remodeling as a proxy for neuromuscular repair a new concept in neuroroboticsthis opens to chronic robotic bioreactors for maintenance of skeletal cardiac tubular organs revisiting fundamental principles of humanrobot interaction with broad impact on health
doping compensation in thin silicon sensors the pathway to extreme radiation environments

silicon sensors have been extensively exploited in highenergy physics experiments in the past 40 years from their first use in na11 at the sps cern to their application in the presentday design of very large particle trackers the capability of silicon sensors to work in environments with high radiation levels has been of utmost importance for experiments at accelerating machines with very energetic and intense particle beams presently available silicon sensors can operate efficiently up to particle fluences of 2e16cm2 while future frontier accelerators envisage the use of silicon sensors in environments with fluences exceeding 5e17cm2 if not overcome this gap will prevent the use of silicon sensors in future hadroncollider experimentscomplex aims at extending the range of operation of silicon detectors by more than one order of magnitude up to a fluence of 5e17cm2 the idea behind this unprecedented target in radiation tolerance relies on a novel understanding of the saturation of the radiation damage and on the advantages that compensated implants bring to radiation hardness the application of these two breakthroughs to thin silicon sensors 2040 microns with an internal gain of 1020 will allow the design of sensors able to operate up to the target fluencei am the pi of three projects to develop silicon sensors for extreme fluences exflu infn exfluinnova aidainnova flex unito which represent preparatory developments for the complex proposal in this context i introduced the principle of doping compensation in silicon sensors to the detector community my expertise in the design and testing of silicon sensors my involvement in radiation hardness studies and my experience in project coordination qualify me as a recognised expert in the development of sensors for extreme fluences and enable me as pi to target the complex goals
unveiling novel metabolitedriven signalling pathways that regulate carbonnitrogen imbalance associated to plant stress

environmental stresses trigger metabolic changes that alter the internal carbonnitrogen cn balance in plants to promote tolerance at the expense of growth however the metabolic and genetic components involved in the precise coordination of the nutritional status remain largely unknown metabosignals aim is elucidating novel signalling mechanisms governing nutrient balance by using cn stress conditions as a proxy this 3year project proposes the integration of molecular genetics and biological chemistry disciplines to identify signalling functions of intermediate metabolites derived from c and n metabolism and characterize new nutritional sensors of cn balance here several innovative and powerful methods for chemical distribution mapping proteomics and transcriptomic analyses are integrated in a convergent workflow with gene functional characterization to be carried out in cuttingedge institutions such as university of california san diego and universidad politcnica de madrid implementation of this multidisciplinary proposal will greatly bolster the fellows scientific profile and will uncover novel metabolitecontrolled signalling pathways useful for knowledgebased improvements on plant nutrition and crop yield of scientific and societal relevance
fast track to cleaner healthier urban aerosols by market ready solutions of retrofit filtration devices for tailpipe brake systems and closed environments

emissions of the existing gasoline engines and brakes of the commercial vehicle fleets in europe relate to health problems and death of annually 145 mio people for the next decades these vehicles will continue populating the roads emitting pmpn exhaust particles and toxic secondary emissions for immediate reduction retrofit solutions for tailpipe and brake emissions must be brought to trl 8 and introduced to the market by 2025 timing is crucial retrofits are transition technologies until full electrification of europes transport fleet even beyond brake retrofits play an important role in the electrified fleet quick wins in the reduction of the overall footprint of the existing fleets can be realised by using our 3 retrofits for tailpipe brake and closed environments 95 of pm25 and 80 of toxic secondary emissions using an innovative gasoline particle filter 60 of nox exhaust emissions replacing the aged twc by original equipment 90 of the brake particles of longlived road transport assets using a passive bdpf 90 of particles in closed environments bus stops tunnels metro stations using a special designed and enhanced stationary air purifier to create credible key messages for clients citizens and policy we perform lighthouse demo activities 1 tailpipe retrofit 1000 vehicles in 2 climate zones germany israel for 4 representative engine type families 2 brake retrofit define emission fingerprints for the public transport of the cities of valladolid ancona fermo and sofia and 35000 km lab testing on dynamometer and 8000 km real driving 3 air purifier retrofit for closed environments 3 underground stations sofia 2x lisbon with 130000 commuters and valladolid central bus depot with 150 busesfor market preparation we will reach 4000 citizens and policy makers from eu kom level and 8 eu countries we unite world leading industry renowned scientific institutes and lighthouse demo sites in 8 european countries
circuit quantum electrodynamic spectroscope a new superconducting microwave quantum sensor

superconductivity is a remarkable phase of matter which has advanced a wide variety of fields including particle accelerators biomedical imaging tools and quantum computers however there are fundamental open questions about the nature of the superconducting state in many materials with new ones being discovered every year understanding their structure can help unravel the dynamics of interacting manybody quantum systems and lead to a next generation of technological innovationssuperconducting circuits are macroscopic tunable quantum devices which can interact strongly while maintaining high coherence making them a leading quantum computing platform these advantages also make them excellent quantum sensors and as they are entirely superconductorbased and operate at microwave frequencies well below the gap energy of most materials superconducting circuits are ideally suited for the exploration of novel superconductorscqedscope will utilize superconducting circuits to expand our understanding of superconductivity in three ways 1 using strong coupling to kinetic inductance we will probe the structure of the superconducting order parameter in micronsized samples such as flakes of layered materials orders of magnitude below current techniques 2 using nonlinearity we will implement a microwave analogue of raman spectroscopy allowing us to probe a wide frequency range and observe collective modes within the superconducting phase 3 using quantum coherence our circuit will interact with the higgs collective mode to create the first higgspolariton a novel quantum system by itself and a new path to study the superconducting structure in addition to our contribution to the understanding of novel superconductors cqedscope will also develop a new quantum sensing tool for material exploration and a promising new class of hybrid superconducting circuits with potential quantum technology applications
triaxial stresses anisotropic damage and directional fluid flow across scales

the ability to accurately predict both the magnitude and direction of fluid flow within fractured rocks is paramount for the secure injection of fluids into the subsurfacean essential operation for geothermal energy production and co2 storage even though the stress conditions at depth control the creation of fractures and the transport of fluids through them technical difficulties have impeded the replication of crustal conditions in the laboratory and the knowledge of fracture development comes primarily from experiments conducted under simplified twodimensional stress conditions this limited perspective has restricted the understanding of the interplay between threedimensional stresses the geometry of developed fracture networks and the direction of fluid flow within fractured rocks furthermore a key challenge for largescale fluid flow prediction is the extrapolation of results obtained at the laboratory scale centimetres to actual reservoir scale hundreds of meters to kilometres this project triflow will use for the first time a novel apparatus to deform samples under representative crustal conditions to establish how 3d stresses influence fracture geometry and directional permeability these results will be combined with innovative 3d mapping methods applied to natural examples of fossilised fluid flow in the form of vein networks and numerical analyses to study the dynamics of tridimensional fluid flow across scales the outcomes of this project are expected to bring substantial advancements to our comprehension of fluid flow dynamics under genuine crustal conditions this improved understanding will in turn enhance the precision of fluid flow simulations for applications involving the injection of fluids into fractured rocks thereby contributing to the safety of processes such as geothermal fluid injection for energy generation and co2 storage both of which are crucial solutions for reducing greenhouse emissions to the atmosphere
jama and her23 antagonistic strategy in targeting breast cancer

breast cancer is the most common female malignancy and a leading cause of death although molecular technologies have led to new therapeutic targets for breast cancer much remains to be done to reduce its societal and economic impact this project focuses on an emerging cancer drug target junctional adhesion moleculea jama an adhesion protein that dr hopkins supervisor rcsi and others have implicated in breast cancer this proposal centres around recent data suggesting that jama controls the expression of her2 and her3 key tyrosine kinases associated with aggressive breast cancer i will test the novel hypothesis that combining a jama antagonist and an antiher2her3 drug pertuzumab exerts synergistic antitumour effects in breast cancer settings this will be accomplished by testing the combination of a jama antagonist and an antiher2her3 antibody for antitumor efficacy in 2d and 3d models of breast cancer in vitro using chick embryo xenograft assays cell linebased and patientderived xenograftbased to test the combination of a jama antagonist and an antiher2her3 antibody in vivo identifying new jama antagonists and test them for synergism with an antiher2her3 antibody in breast cancer settingsvalidating a possible jamaher2her3 signalling axis in breast cancer patient datasets and samples combining an innovative multifaceted approach and offering an academic multidisciplinary environment which will both complement my industrial skills and enable me to transfer valuable industrycentred knowledge this project presents a wealth of opportunities to enhance by career prospects and enable a transition back to academia as there are currently no antijama drugs on the market or in clinical trials this is a timely and important project which will give valuable new translatable knowledge into the treatment of certain aggressive breast cancer phenotypes
european knowledge hub and policy testbed for critical infrastructure protection

the main goal of eucip is to establish a novel pan european knowledge network for resilient infrastructures which will enable policy makers to shape and produce datadriven evidencebased policies while boosting the innovation capacity of critical infrastructures ci operators authorities and innovators including smes in this direction the partners have already established the european cluster for securing critical infrastructures ecsci which brings together 22 projects that collaborate in ci resilience eucip will leverage the capacity organization community and achievements of the ecsci cluster towards establishing an euwide knowledge network with advanced analytical and innovation support capabilitiesthe projects analytics capabilities will fulfil the reporting requirements listed in the call in terms of the number and the semestrial frequency of the reports to facilitate information collection and analysis the project will establish a fair data observatory of research projects research outcomes technologies standards and policies along with analytical capabilities for evidence based policies the project will organize and offer a rich set of innovation support services to eu projects and other innovators in ci security and resilience these services will include training support in business planning and access to finance as well as support in the validation standardization and certification of novel solutionsthe projects outcomes will be integrated and made available through a knowledge hub which will provide a singly entry point to the eucip results eucip will build a vibrant ecosystem of over 1000 stakeholders around this knowledgehub to animate and grow the projects community eucip will execute an ambitious set of dissemination activities including the establishment and organization of an annual conference on critical infrastructures resilience which will become a flagship event for critical infrastructures
seamless design of smart edge processors

with the rise of deep learning dl our world braces for artificial intelligence ai in every edge device creating an urgent need for edgeai processing hardware unlike existing solutions this hardware needs to support high throughput reliable and secure ai processing at ultralow power ulp with a very short time to marketwith its strong legacy in edge solutions and open processing platforms the eu is ideally positioned to become the leader in this edgeai market however certain roadblocks keep the eu from assuming this leadership role edge processors need to become 100x more energy efficient their complexity demands automated design with 10x design time reduction they must be secure and reliable to get accepted finally they should be flexible and powerful to support the dl domainconvolve addresses these roadblocks and thereby enables eu leadership in edgeai to that end it will take a holistic approach with innovations at all design stack levels including1ulp memristive circuits for computationinmemory2fast compositional design of systemonchips soc3transparent compilers supporting automated code optimizations and domainspecific languages4rethinking dl models through dynamic neural networks eventbased execution and sparsity5onedge continuous learning for improved accuracy selfhealing and reliable adaptation to nonstationary environments6holistic integration in socs supporting secure execution with realtime guaranteesthe convolve consortium includes some of europes strongest research groups and industries covering the whole design stack and value chain in a community effort we will demonstrate edgeai computing in reallife vision and audio domains by combining these innovative ulp and fast design solutions convolve will for the first time enable reliable smart and energyefficient edgeai devices at a rapid timetomarket and low cost and as such open the road for eu leadership in edgeprocessing
assessing the role of hydrothermal alteration on volcano morphology instability and unpredictable volcanic hazards

more than 10 of the worlds population are at risk to the direct impacts of volcanic eruptions volcano monitoring aims to detect and correctly interpret volcanic hazards and to provide early and accurate warnings of impending eruptions yet despite technical and scientific advances volcanoes still produce unexpected explosive eruptions or sudden flank collapses each year such unpredictable events result in volcanic disasters that devastate unprepared communities and destroy unprotected infrastructures previous work by the pis indicates that volcanic hazards are caused by hydrothermal alteration which progressively and imperceptibly changes the chemical and physical state of rocks inside a volcano creating a soft and unstable or rotten interior however the link between soft volcanoes and unpredictable volcanic events remains enigmatic the rottnrock project aims to achieve a groundbreaking advance in our understanding of hydrothermal alteration processes that act inside active volcanic systems specifically we will identify where and at which scales alteration occurs wp1 explore the chemical fingerprint of alteration and effects on rock properties and strength using laboratory methods wp2 and develop 4d volcano stability simulations and therefore an innovative and optimised hazard assessment workflow wp3 the rottnrock project combines innovative approaches from traditionally distinct geoscience disciplines remote sensing mineralogy and chemistry rock mechanics and modelling this project will revolutionise our understanding of hydrothermal alteration and its effects on volcano hazards and pave the way for strategies to forecast and mitigate unexpected volcanic events caused by hydrothermal alteration and circumvent disasters at volcanoes worldwide