Dragon09/odtu_chatbot huggingface dataset:
novel immunotherapies for tuberculosis and other mycobacterial diseases

tuberculosis tb remains the leading cause of death due to a single pathogen mycobacterium tuberculosis mtb except in 20202022 when it was surpassed by the covid19 pandemic with 15 million deaths in 2020 the lengthy tb treatment and the numerous adverse events contribute to poor medical adherence and development of antibiotic resistant strains thus novel therapeutic modalities are urgently needed to shorten treatment duration improve outcomes and control the emergence of drug resistant tb the ithemyc project convenes a multidisciplinary consortium of 11 partners including two product development partnerships tbvi tballiance and an industrial partner gsk involved in vaccine drug and biomarker rd for tb the partners will work jointly to develop innovative adjunctive tb immunotherapies by capitalizing on a promising pipeline and recent developments in the field the project will combine current and new antibiotic regimens with novel immunotherapies such as small molecules targeting host pathogeninteractions including hostdirected therapies and virulence inhibitors immunomodulatory compounds monoclonal antibodies and therapeutic vaccines the project will generate robust preclinical safety and efficacy information on compounds and combinations through a set of relevant in vitro in vivo and in silico models and progress two of them up to preclinical proofofconcept in nonhuman primates within the project duration the partners are proposing a critical path for characterization and progression of immunotherapies that will be refined based on knowledge generated in ithemyc aiming to increase the understanding and interest for this emerging concept of adjunctive tb immunotherapy we expect the new combined interventions will improve tb cure rates reduce the duration and toxicity of current regimens and reduce relapse rates
valorization of undervalued recycled polyethylene terephthalate rpet by supercritical co2assisted extrusion foaming co2assisted extrusion

during the last century the unique properties of plastics have enabled human civilization to continuously improve its living conditions an example is the polyethyleneterephthalate pet that has become the primary packaging material of beverage containers however the short life cycle of these materials created a significant environmental problem as they tend to end up in landfills or occasionally in the environmentin this project the mechanical reprocessing method of colored pet is going to be combined with extrusion foaming assisted by supercritical carbondioxide scco2 that presents high advantages as a high dissolution in polymers enables foamed products with very low density and a green process since co2 is an environmentally friendly physical foaming agentthe project is fully in line with the interests of the researcher dr daniel vadas he has been studying the co2aided extrusion foaming technology for 7 years firstly he successfully produced and characterised flameretarded poly lactic acid pla foams in 2015 and managed to secure 1st place on the conference of student research societies at both university and national levelthe project proposed herein will enable him to acquire and reinforce unique researchrelated experiences and transferable skills in mechanical recycling of lower value postconsumer pet waste as well as in management and entrepreneurship the intersectoral industrial relationships of the host organization whom the candidate will closely and intensively collaborate with would significantly improve his leadership competencesthe project results will improve the recyclability of almost nonrecyclable colored pet thereby reducing the volume of plastic materials sent to landfill or incineration
cryogenic nanoscale metrology of quantum circuits

quantum computing holds the potential to highly impact our society and revolutionize scientific research healthcare finance and beyond as the complexity of quantum circuits increases advanced tools for nanoscale metrology of the sources of decoherence and energy loss will become vital for large scale fabrication inspection and optimization of quantum devices and microcircuits the main obstacle is that in contrast to classical computation solid state quantum devices operate at subkelvin temperatures at which the currently available microelectronics metrology and thermal imaging techniques are inoperable in our erc adg project we have developed a groundbreaking technique that provides for the first time cryogenic thermal imaging down to mk temperatures with four orders of magnitude improvement in thermal sensitivity over the stateoftheart roomtemperature methods based on superconducting quantum interference device on the apex of a sharp tip sot it allows nanoscale imaging of the minute heating and energy loss arising from electron scattering off single atomic defects that can provide the crucial metrology of the decoherence sources in quantum devices moreover the sot delivers simultaneous imaging of the electrical currents flowing in superconducting circuits essential for inspection and optimization of superconducting qubitsthis poc project is aimed at adaptation of the sot lab technology to industrial metrology applications including development of reproducible industriallycompatible device fabrication methods boosting their environmental durability enhancing the sot functionalities and development of sustainable characterization methods we will develop ipr strategy explore establishment of industrial partnerships and promote integration of the sot sensors into existing industrial workflows to deliver a precise metrology solution to advance quantum computing development and enhance the competitiveness of the european industry
cocreating peoplecentric sustainable neighbourhoods through urban regeneration

the project wegenerate as signified by its name seeks to infuse the elements of people and cocreation in the urban regeneration processes it fully embraces the paradigm shift from building for the people to building with the people we cities citizens communities businesses researchers and practitioners take ownership of the urban regeneration processes and cocreate together sustainable peoplecentric accessible and beautiful neighbourhoods this project is based on the stories of four neighbourhoods and their communities located in different parts of europe although they are at different stages of development and are facing different urban challenges but they share the same vision of positive change wegenerate will help them to reinvent themselves and in the process find new values and opportunitieswegenerate sets out a journey to find the right ingredients and recipes for sustainable and inclusive urban regeneration that can create longlasting positive impacts within the neighbourhoods and beyond the process will be highly participatory with close collaboration with the city administrations as well as the citizens local communities and businesses advanced digital applications such as digital twins metaverse and extended reality will be implemented and experimented to support decisionmaking and stimulate citizen engagement expertise in social science and humanities is called upon to foster social innovation and participatory actions across the project in addition to technological and social interventions the art and cultural dimensions will be drawn on in the cocreation processes four sustainable and peoplecentric neighbourhoods will be realised by the end of the project the legacy will be upheld through replication by five fellow cities and others who are inspired by the wegeneration stories
enhancing tensor network approaches for rydberg atom quantum simulators

recent experiments with ultracold atoms trapped ions rydberg atoms and superconducting circuits succeeded in realizing quantum manybody states at unprecedented sizes and thus investigating their static and dynamical properties these achievements have boosted the search for protocols to observe exotic phases of matter in quantum simulators and to implement quantum computations unaffordable for classical supercomputers i aim to investigate rydbergatom platforms improving their efficiency for future quantum simulation and computation tasks motivated by their versatility and manipulation capability classical numerical simulations are fundamental to developing quantum simulators engineering efficient experimental protocols and benchmarking the results still an exact representation for large quantum manybody states is highly inefficient and impossible to achieve for the sizes available in current experiments i will exploit advanced numerical tensor network methods to simulate the outofequilibrium properties of highly constrained quantum phases as topological spin glasses and quantum scars recently realized on rydbergatom highdimensional lattices indeed tensor networks are a balanced approximation between accuracy and computational resources and are the ideal set of tools to investigate constrained regimes in quantum manybody systems realizing this project first at the lukin quantum optics group at harvard university and then at thequantum theory group at padova university i will access worldleading experimental and numerical expertise to perform cuttingedge analytical numerical and experimental investigations on rydberg atom platforms in addition i will acquire experiment modeling expertise and apply them at the nearfuture quantum computation laboratory at padova university this project is aligned with the quantum technologies flagship making me valuable for future innovative research on competitive quantum technologies applications
social aspects of the green transition sogreen

the goal of the sogreen project is to enhance the capacities of the four leading social science infrastructures in europe ess eric share eric ggp and guide and generate valuable insights aimed at facilitating the study and evaluation of the social aspects of the green transition for different generations and socioeconomic groups across europe using a lifecourse perspective sogreen will contribute to the work programme topic next generation of scientific instrumentation tools and methods and advanced digital solutions by developing new services comprising innovative tools solutions and questionnaire modules related to the social aspects of the green transitionthe unique longitudinal and multigenerational perspective of the infrastructures involved goes beyond the state of the art by integrating new data and novel analytical frameworks to foster interdisciplinary insights on the green transition at national and regional levels including new services including geospatial data linkable with survey datasets and new visualisation tools central to our approach is the collaborative development of a new tool the green transition questionnaire module to ensure coherence in addressing environmental themes which will then be fielded within the different surveys moreover we will also prepare harmonised aggregates of collected data and their visualization through a joint dissemination platform enhancing accessibility and promoting consistency in data interpretation across various studies the knowledge mobilisation lab will be another new and innovative tool to identify build and engage a multifaceted network of different audiences and stakeholders this includes professionals from policy research nonprofit and private sectors thus actively shaping the discourse and informing developments related to the green transition
accurate reconstruction of microbial genomes from the environment

metagenomeassembled genomes mags obtained from metagenomics are of fundamental value to understanding diverse ecological niches of microbes such as the human gut with applications in medicine biotechnology and climate science however the quality of mags constructed with stateoftheart tools is often unsatisfactory and worse than the selfreported quality the main source of error is binning a computational step that groups sequences assembled from short sequencing reads contigs into specieswise bins the two chief challenges are accurately binning 1 genomes with low abundance and 2 highly conserved regions due to crossmapping of reads the contigs from conserved regions appear to have abundances equal to the sum of the abundances of the related species or strains as conventional binning tools all rely on clustering contigs according to their abundances across samples conserved regions end up forming separate bins besides most existing methods optimise quality measures purity and completeness based on conserved marker genes and assess the final quality on these very measures leading to highly optimistic results i aim to solve these problems by developing a binning algorithm that applies i linear mixture models using nonnegative matrix factorization to account for crossmappingii poisson statistics to accurately model low abundance and iii bayesian statisticsbased multinomial clustering to calculate bin numbers importantly it does not require marker genebased quality measures for binningby improving the binning of lowabundance and highly conserved contigs this approach should yield more highquality mags thereby enhancing a multitude of downstream metagenomic analyses for all areas of microbiome research
wrap it up deciphering experiencedependent myelin growth across development

humans start life fully dependent on the care of others yet we go on to acquire skills no other species is capable of what is the biological basis of this remarkable plasticity animal studies suggest a critical role of myelin in learning and brain plasticity while postmortem assessments of the human brain show that myelin maturation which is completed around birth in other species continues until adulthood how does this uniquely protracted myelin development enable and constrain our aptitude for learning wrapped will answer this critical question by assessing changes in myelin during learning at different developmental stagesrecent critical advances in mri technology now provide the unprecedented opportunity to compare myelin levels within the living human brain over time and between individuals making it possible to probe the role of myelin in human learning for the first time seizing this opportunity wrapped will assess learningrelated changes in myelin using an innovative twopronged approach that combines local longitudinal studies with the analysis of largescale open data critically wrapped will not only evaluate adults but rather probe the entire developmental lifespan to show how myelin changes as infants learn to crawl when children enter school and when children young adults and older adults are acquiring the same novel skills juggling and reading chinese this ambitious developmental focus will be transformative for our understanding of the interactions between maturational and learningrelated changes in myelin thereby wrapped will elucidate the biological basis of the unique human learning trajectory that allows us to establish and maintain complex cultures this characterization of healthy human brain plasticity in turn will serve as a vital reference point for understanding psychological and neurological disorders linked to alterations in myelin such as schizophrenia autism and childhood learning disabilities
maasivetwinmanufacturing as a service and supply chain predictive twin for critical raw materials

maasivetwin aligns with the vision of creating a competitive and sustainable digital europe and green value chain by even combining the two aspects this twin enables manufacturing as a service by tracking mining and processing of critical raw materials crm which will be tested by the first lirefinery in europe rocktech and the first large scale lifepo4 battery manufacturer elevenes the twin helps to improve efficiency of the supply chain reduce uncertainty and support informed decision making all of which are critical for supporting the transition to a more sustainable economy maasivetwin will provide realtime data analysis and insights of crm mining shipping processing and sustainability additionally by predicting scenarios based on disruptive events such as suez channel blockage the tool will enable participants to use other suppliers as manufacturers as a service in case of supply chain disruption to keep machinery in their factories running increase utilisation and enable fully integrated resilient value chains from mining of crm till the end productsmaasivetwin extends the analysis of critical materials for eg li co ni that go into batteries light and heavy rare earth elements that go into magnets for wind turbines and emotors vanadium for redox flow cells pt for h2 fuel cells and many more to enable the transition to green energy technologies which are based on crms to achieve the green deal goals fitfor55 and the eu critical raw material act which was proposed in 032023 this digital twin will track the path towards our ambiguous eu goals and make european crm value chains more digital and more resilient
in search of perfection the phenomenon of unnatural amino acids in chemical biology for biological and medical applications

perfection foresees launching the department of chemical biology for biological medical applications dcb at the institute of physical chemistry pas ichf by prof marcin drg era chair holder ech an excellent biological chemist with expertise in combinatorial chemistry of proteolytic enzymes and their applicationsichf is renowned for its methods of measuring and analysing physical chemical and biological systems yet we lack biologically relevant molecules to improve these methods and tackle complex health issues we also need more recognition from partners to join project consortia and better exploit our research results under the project dcb will undertake close collaboration with ichfs researchers supplying them with novel compounds modified peptides with unnatural amino acids uaa for broadranging studies on new chemical markers to target diverse diseases dcb will also offer leading structures to support the creation of uaabased drugs similar to those in nirmatrelvirpaxlovid a sarscov2 drug that uses uaa discovered by prof drg and team nature chem biol 2021 the project measures involve revamping the ichf research agenda training guidance and mentorship of ichf researchers by ech coupled with enhanced networking with academic and industry partners we will also tackle the shortage of international researchers available for ichf by setting up training research programmes on drugdiagnostics delivery to further solidify our partnerships with stakeholders we will refine ichfs research management practices notably in ip management and stakeholder communication our efforts will be bolstered by support from 14 research institutions and 6 companies ia stanford university school of medicine genentech kintsugi that have committed to the project the ultimate project goal is to establish ichf as a premier research entity recognised for cuttingedge chemical tools for biological chemistry applications and their market launch
biodiversity genomics europe

the biodiversity genomics europe bge projectthe biodiversity genomics europe bge project has the overriding aim of accelerating the application of genomic science to enhance understanding of biodiversity monitor biodiversity change and guide interventions to address its decline bge coordinates and upscales dna barcoding and reference genome generation in the context of european biodiversity the project develops synergies by aligning efforts and resources of the dna barcoding and genome sequencing communities across the continent the bge objectives with derived ambitions capacity to establish functioning biodiversity genomics networks at the european level to connect and grow community capacity to use genomic tools to help tackle the biodiversity crisiswith the ambition to a futureproof our networks on biodiversity genomics research b lower access thresholds to biodiversity genomics research and c promote cocreation and citizen engagementproduction to establish and implement largescale biodiversity genomic datagenerating pipelines for europe to accelerate the production and accessibility of genomic data for biodiversity characterisation conservation and biomonitoringwith the ambition to a establish distributed and inclusive capacity b build economies of scale and c connect previously disjoined resources to deliver relevant knowledge application to apply genomic tools to enhance understanding of paneuropean biodiversity and biodiversity declines to improve the efficacy of management interventions and biomonitoring programmes with the ambition to a improve the use of biodiversity genomics data in science policy and b establish europeanwide large scale biodiversity genomics research mechanismsthe bge consortium is comprised of 33 partners across 20 countries and brings together for the first time at this scale the two communities for barcoding and reference genome to implement its aspirational programme
modular modelbased design and testing for applications in satellites

the space domain as many other engineering sectors is actively considering novel methods and tools based on artificial intelligence digital twins virtual design and testing and other industry 40 concepts in order to manage the increased complexity of the design of upcoming satellites nevertheless especially from the satellite onboard software engineering point of view these technologies require a solid ground to be built upon first of all the computational power of the hardware platform must meet the needs of the advanced algorithms running on top of it the software layer too must both allow an efficient use of the hardware resources and at the same time guarantee nonfunctional properties such as dependability in compliance with ecss standards finally the design methods need to adapt to the specific challenges posed by both the increased complexity of the hardwaresoftware layers and the industry 40 conceptsthe metasat vision is that a design methodology based on modelbased engineering jointly with the use of open architecture hardware constitutes that solid ground to reach its vision metasat will leverage existing software virtualisation layers eg hypervisors that already provide guarantees in terms of standards compliance on top of highperformance computing platforms based on open hardware architectures the focus of the project will be on the development of a toolchain to design software modules for this hardwaresoftware layer without such measures the time and cost of developing new systems could become prohibitive as system complexity grows reducing competitiveness innovation and potentially dependability across the industrya high quality and complementary consortium comprising knowledge generators ikl bsc and ales plus an sme technology integrator fen and an end user from the space sector ohb will be able to test in a real scenario the new design toolchain that will enable the runtime deployment of software module
eit crosskic shared services

the shared services crosskics objective is to identify and create opportunities for kics to achieve synergies across different common area of concern eit kics by design have a specific status that requires them to adhere to requirements set by eit and the ec in order to be eligible to receive funding the shared services crosskic tackles these requirements largely specified in the call document through different activities 1 clc consolidation to achieve efficiency and impact in building the required kicss presence in europe while enabling facilitate collaborations 2 communicate and disseminate the results of kics activities and engage with the eu policy debate through eit community common events innoveit clc open days as well as flagship premises to engage with specific ecosystems eit house brussels eit hub budapest and 3 comply to operational requirements with an efficient and common approach such as joint procurement of audits for cfs verification on new partners and a common it tooling to manage the eit grant and related reporting