Dragon09/odtu_chatbot huggingface dataset:
extreme particle acceleration in shocks from the laboratory to astrophysics

astrophysical shocks are among the most powerful particle accelerators in the universe generated by violent interactions of supersonic and often relativistic plasma flows with the ambient medium shock waves involve a complex and highly nonlinear interplay between the dynamics of flows magnetic fields and accelerated particles through mechanisms not yet fully understood what is the origin of cosmic rays what controls particle injection and the acceleration efficiency in collisionless shocks how is the physics of relativistic shocks modified by electronpositron pair production can these mechanisms be studied in the laboratory these are longstanding scientific questions closely tied to extreme plasma physics processes and where the interplay between microinstabilities and the global dynamics is critical advances in highpower lasers and particle beams are just now opening unique opportunities to probe the microphysics of shocks and particle acceleration in controlled laboratory experiments for the first time together with the fastpaced developments in fullykinetic plasma simulations computational power and astronomical observations the time is ripe to deploy a research program focused on particle acceleration in shocks that can transform our ability to address these questions in the erc grant xpace we aim to use firstprinciples massively parallel simulations and laboratory experiments to study the microphysics of nonrelativistic and relativistic shocks and to use datadriven techniques to develop multiscale models that bridge the gap between the microphysics and the global dynamics this project will build comprehensive models of the plasma processes that shape magnetic field amplification particle acceleration and radiation emission in shocks with the goal of solving central questions in extreme plasma phenomena opening new avenues between theory computation laboratory experiments and astrophysical observations
a novel bioinformatics saas platform to identify and classify the pathogenicity of single genomic variants and oligogenic variant combinations for the diagnosis and treatment of genetic diseases

genetic diseases affect 300 million individuals worldwide resulting in 28 million new patients every year the advent of next generation sequencing ngs means its now possible to analyze the whole patients genome however variant interpretation is the biggest hindrance to widespread adoption of ngs technologies hence clinicians are struggling to identify diseasecausing variants and the diagnostic yield of genetic disorders is only about 50 on average evai is a revolutionary saas platform that allows geneticists to identify multiple pathogenic genomic variants with unprecedented accuracy and speed we bring to market 1 first and only digenic and oligogenic variant interpretation 2 best predictive causative variants accuracy 3 reduced turnaround time and 4 consistency of variant interpretation 5 discovery of unknown variants
concepts tools and applications for communitydriven bioeconomy development in european rural areas

the overall goal of scaleup is to support regional multiactor partnerships consisting of private businesses governments and policymakers civil society organisations and researchers in identifying and scalingup innovative and sustainable biobased value chains that build on regional resources through its approach scaleup will adapt implement and evaluate tools to help regional actors to overcome the apparent bottlenecks towards fully exploiting bioeconomy potentials in their region a four phase methodology will i establish existing knowledge and set the stage for further research as well as creating six regional platforms with local stakeholders ii facilitate crossregional transfer of knowledge and demanddriven capacity building and provide support to multiactor partnerships to carry out market assessments and business model designs iii create a paneuropean community of practice to facilitate sharing good practices and lessons learned across european regions and iv disseminate and exploit project results in collaboration with key stakeholders in addition to the focus on increasing capacity and knowledge on the bioeconomy among relevant actors in the regions a key feature of scaleup is the business development programme to be applied by the local communities with an emphasis on the principles of cocreation transparency and open innovation the project will provide advisory support to innovators and regional stakeholders to assess market conditions elaborate business plans and identify compatible funding sources for 12 biobased solutions
women in the nordic enlightenment changing the narratives of early modern philosophy and uncovering womens contribution to scandinavian gender equality

the enlightenment attracts a lot of scholarly attention due to its relevance for the emergence of modern philosophical thought and the identity of presentday europe yet womens contribution to the enlightenment has been largely ignored whence will fill this research gap in an original and groundbreaking way by focusing on an hitherto overlooked geographical region namely europes north by targeting the writings of scandinavian women whence will provide results that describe the nordic way of womens enlightenmentthe guiding hypothesis is that this nordic way significantly differs from developments prevalent in other regions of europe and that women played a decisive role in creating a sustainable identification of the nordic countries with gender equalitythe overall objective of whence is to uncover and critically assess womens intellectual contribution to the nordic enlightenment this investigation includes two further objectives namely to change the standard narratives of the development of the nordic enlightenment and to assess womens role in the emergence of scandinavian gender equality what was womens intellectual contribution to the nordic enlightenment how does womens thought change our understanding of the individual and of society during the early modern period what was the impact of womens thought on the emergence of scandinavian gender equalityto adequately investigate womens writings the project uses various methods in an original way it combines classical philosophical analysis and archival research with new insights developed in gender studies and feminist history of philosophy moreover whence has a strong interdisciplinary outlook and uses the new tool trajectories to relate historical findings to contemporary debatesgiven the persistence of gender inequality in todays society the threats women are facing in the public sphere and the upheaval caused by the metoo movement this project is essential and timely
intracellular carrier against resistant microorganisms icaro

intracellular pathogens and viruses elicit immune responses by presenting their antigens to t cells at the same time they have evolved immune evasion mechanisms which essentially reduce the antigenic repertoire that is presented to the immune system to overcome this problem the eicfunded icaro project proposes to use siliconbased microchips that carry pathogen antigens and can be internalised by immune cells to aid antigen presentation these biochips are retained within cells for a long time and will provide the foundation for a novel vaccination strategy that can boost specific and longlasting t cell responses the consortium aims to develop standardized methods for icaro manufacturing and functionalisation to be easily applicable to different pathogens thus accelerating the generation of new vaccines in the future
european coordination network and activities to embrace a sustainable and inclusive steam educational system the blend of artistic and creative approaches in stem education research innovation

this project aims to bridge the current gender gap in stem science technology engineering and mathematics fields by unlocking the potential of steam stem arts education approach for future european innovators especially women thus this project will establish a coordination alliance at european level and develop numerous networking and educational activities using a creative thinking and a scientific evidencebased approach this will lead to broad sustainable environmentalresponsible socialinclusive economicallybalanced and inclusive gender geodemographic and socioeconomic wideranging steam education methodology that will positively influence in the transition towards a cultural and social cohesion of europe this eu interdisciplinary consortium will follow a multiactor approach where cultural and creative industries ccis are drivers of the cultural and creativedriven innovation ecosystems combined with validation with 1118 years old students that will allow to better understand the gaps and limitations of stem education regarding country age gender and other sociocultural aspects and boost the change towards a sustainable reproducible inclusive european steam educationas a result this csa project will deliver a digital hub for participant networking both students and stakeholders missing information on steam level of implementation in europe numerous countryadapted training activities to boost integration of steam approaches in secondary and vocational training schools with specific activities for young women and rural students a pilot of the steam week at eu level and a roadmap for annual reproducibility as well as followup training courses and guideline of minimum requirements for teachers and educational managers to ensure a steam education across europe moreover the project will extensively disseminate and communicate projects events results and findings including the development of recommendations
disordered metalorganic frameworks for drug delivery

drug delivery systems are often needed for delivering drugs in a targeted organ or tissue at a desired concentration range and without toxic side effects metalorganic frameworks mofs have emerged as promising drug delivery systems due to their high loading capacity but currently this is also their main limitation as it results in too rapid drug release in the human body causing an excessive response and potentially toxic side effects slowing down the drug release rate while maintaining high loading capacity and biocompatibility would enable applications within especially cancer therapydisordered mofs ie mofs without an ordered crystalline structure have smaller pores and more torturous pathways for drug release the projects proposed strategy is to load anticancer drugs in the crystalline mof with high surface area and thus high loading capacity and then subsequently subject this material to an ordertodisorder transition giving rise to slower drug release this transition can be induced by either mechanical ball milling or thermal meltquenching molecular dynamics and classificationbased machine learning will be used to identify which local atomic structures are best correlated with drug release rate in disordered mofs experimental validation will be performed to establish design principles for mof structures with a tailored drug release profilethe project builds on complementary expertise of the fellow applicant disordered biomaterials in vitro studies and supervisor mofs simulations machine learning combined with the research and training environment offered by the host organization aalborg university denmark this will ensure the achievement of this novel project as well as the dissemination and exploitation of the results the goal is to develop principles for designing disordered mofs for drug delivery the fellow applicant will emerge from the project with new skills and the capability to launch his own research group
unlocking data content of organonchips

the launch of a novel drug to the market is preceded by clinical testing and validation both on animal in vitro and in vivo models animal models used in drug development have known methodological drawbacks leading to the failure of drugs further animal tests are associated with ethical issues moreover a strong bias in inhuman testing still overlooks major population groups eg children women different ethical groups it is estimated that 197000 deaths per year in the eu are caused by adverse drug reactions adrs and the total cost to society of adrs is 79 billion the emerging organonchip ooc field an alternative to animal test brings great potential for safe testing and validation an oocsystems consists of a 3dmicrostructured channel network embedded on a small plastic device that simulates the mechanics and physiological response of an entire organ or organs project unlooc will develop optimize and validate a multitude of ecsbased tools to build oocmodels to replace animal and inhuman testing unlooc aims to combine three important characteristics for routine use of ooc models ie platforms that combine ecsbased technologies with established biological material capitalize on ai parallelized test setups allowing efficient highthroughput demands and standardized procedures enabling reliable results unlooc will develop ecsbased hardware and software tools and validate them in five use cases ucs performed in 10 european countries the applications developed and validated will be used by academia and pharma industry to drive drug development create cosmetics without animal test personalized medicine and gain new insights into disease given the large ooc market these solutions have great economic value on average it would result in cost reduction of up to 169m and 706m per new drug reaching the market and will put europe at the forefront of this booming research field see impact section for details
hyperfine coupled spins with time evolution readout

quantum simulation is a promising strategy for understanding the behaviour of quantum systems that are too complex to be calculated directly hypster will make crucial steps towards creating a quantum simulator from individual magnetic atoms addressed by means of a scanning tunnelling microscope i will engineer atomic structures combining electron and nuclear spins coupled to each other via hyperfine interaction and read out their collective quantum coherent evolution in real timethe lifetime of any quantum state is limited by its coherence time while electron spins on a surface suffer from continuous decoherence due to electrons from the substrate nuclear spins are much better isolated holding potential for orders of magnitude longer coherence times by providing controlled access to the realtime dynamics of the nuclear spin hypster aims to unlock this invaluable potential first expanding upon a unique measurement procedure developed in my group i will trace the combined time evolution of a nuclear spin coupled to an electron spin allowing quantum information to be exchanged between the two next i will explore methods to controllably couple and decouple the nuclear and electron spins by rapidly adjusting the local hamiltonian this will allow the nuclear spin to evolve by itself not hindered by external decoherence sources finally i will employ dualfrequency electron spin resonance to enable remote detection of spin dynamics constructing a pathway towards connecting multiple nuclear spins over a distancethe objectives of hypster will provide a toolset that can be readily adopted throughout the blooming field of onsurface spin systems and set the stage for true atomicscale quantum simulation
singlecell metabolomics for drug discovery and development

despite the major efforts in the modern drug discovery and development the field is still in its crisis with the productivity increasingly declining a major source of drug development failure is the toxicity where the adverse drug reaction is often caused by offtarget effects of drug candidates that can be revealed only late in the drug development process metabolomics was proposed as an emerging promising approach to monitor offtargets effects on metabolic enzymes or transporters thus providing mechanistic understanding of drug toxicity however there are multiple challenges in applying metabolomics in this context including the inability to resolve the drug metabolic response on the singlecell level in this poc project we propose to commercialize the technology of singlecell metabolomics developed in the erc cog project metacell specifically we propose using our singlecell metabolomics technology in conjunction with the datadriven metabolic modulation approach for revealing singlecell metabolic response and metabolic mode of action of drugs and drug candidates
are big firm control and ownership structures crucially shaped by entwined fiscal policies

corpcontrolintax aims to understand the role of taxation in explaining the development of widely dispersed share ownership in countries like the united kingdom and the united states in contrast to the persistence in many continental european states like germany and italy of corporate ownership structures characterized by controlling shareholdersthe nature and structure of corporate ownership is a fundamental issue in comparative corporate governance as the idea that ownership concentration limits economic growth and financial development is a central cornerstone of modern corporate finance indeed familyowned listed companies especially those that are heircontrolled firms may produce downsides not only in terms of lowering firm value and profitability but also by curtailing the functioning of the market for corporate control and engender the extraction of private benefits by the controlling families to the detriment of the minority shareholdersaccordingly corpcontrolintax investigates the role of taxation on corporate governance in a comparative setting focusing on the british and american experience on the one hand and the german and italian on the other to achieve its goals the project plans to track from the 1950s on the evolution of corporate ownership structures in the united kingdom united states germany and italy in connection with the concomitant changes in their tax frameworks the purpose is to gauge whether different ownership structures ie different frameworks of corporate ownership and control in the uk us germany and italy echo divergences in their tax systems including as regards inheritance taxes capital gain tax rates and income taxes therefore corpcontrolintaxs wide scope considers issues that affect not just one but several countries in europe this study does also have special importance for those eu member states where low productivityrelated issues are at the forefront of policy debates
european partnership on transforming health and care systems

health and care systems in europe are facing core common challenges which require harmonised and coordinated solutions the european partnership on transforming health and care systems thcs represents a unique strategic opportunity to bring together stakeholders create synergies coordinate research and innovation actions facilitate the digitization of health and care services and support the transformation of health and care systems with innovative solutions driven by knowledge and evidencethe general objective of thcs is to contribute to the transition towards more sustainable efficient resilient inclusive innovative and highquality peoplecentred health and care systems equally accessible to all people for this purpose thcs aims not only to create new knowledge and scientific evidence but to codesign new solutions and support their transfer and scaleup across countries and regions while also fostering capacity building the approach for a successful and smooth implementation of thcs will focus on three main work streams 1 filling the knowledge gaps with research actions aiming at providing the necessary evidence 2 implementation and transfer aiming at supporting actions focusing on the testing of existing solutions and adaptability in different national and regional contexts and 3 boosting health and care systems through dedicated activities capacity building and trainings study visits technical assistance twinning networking involving different health and care stakeholders to address these three work streams thcs is built around four pillars that group different types of activities addressing different types of stakeholders of the health and care system the activities are organised in ten work packages working closely together to achieve the objectives of the partnership and clustered in the four pillars
rapid portable and reliable cargo screener new concept of vapour screening technology ion mobility chemical fingerprint detector

safe and legal global transport is essential to human welfare but it demands that customs authorities implement security regulations with a special focus on illicit goods to enable enforcement of regulations tackling illicit goods trafficking customs authorities have expressed their need for portable affordable nonintrusive reliable screening technologies aiming to facilitate onsite and rapid inspections the current technologies are mainly based on xray screening but have its limitations in detecting illicit goods are very expensive and the process is time consuming this makes that currently less than 5 of the containers may be inspected which is undesirable for customs authorities and society in the meteor project the consortium will develop a prototype of a portable and versatile air samplingbased screening system this will enable customs administrations worldwide to rapidly and reliably inspect for the presence of illicit goods the meteor technology will provide a new concept of cargo screening detector with a highly efficient air sampling technique and the ion mobility multidetector sensing technology the meteor analyser relies on a very innovative concept of a multidetector differential mobility analyser dma that classifies molecular ions based upon their electrical mobility this generates a chemical fingerprint of the samples and after the processing with nontargeted screening techniques it is possible to accurately classify and detect the threats the focus will be on the detection of illicit drugs but also explosives and other substances the goal is to develop the meteor technology up to trl7 and validate it in the operational environment this is done by the four customs administrations the netherlands belgium spain and ireland involved in the project that cover some of the main ports in europe