Dragon09/odtu_chatbot huggingface dataset:
targeting nlrp3mediated inflammation with novel chemotypes

inflammasomes play a vital role in in protecting humans against pathogenic microorganisms harmful substances and cell changes that could result in illness the nlrp3 inflammasome in particular attracts considerable interest because aberrant nlrp3 activation is a key pathogenic mechanism in many chronic inflammatory diseases moreover gainoffunction mutations in nlrp3 causes a periodic fever syndrome named cryopyrinassociated periodic syndrome caps mcc950crid3based sulfonylurea compounds are currently the only reported class of inhibitors that selectively target nlrp3 with nm potency we and others recently showed that members of this sulfonylurea class inhibitors directly target the central nacht domain of nlrp3 and several companies have recently progressed mcc950crid3derived nlrp3 inhibitors to human studies however there is an urgent need to expand the pipeline of nlrp3targeted therapeutics with nlrp3inhibitors of novel chemotypes based on exciting preliminary data we aim to identify novel nlrp3 inflammasome inhibitors and perform an indepth functional analysis of their activity selectivity and molecular mechanism of action furthermore we will define the market potential and explore the best strategy towards clinical development with partner organizations in conclusion the project will help to expand the pipeline of nlrp3targeted therapeutics with new nlrp3inhibitors if successful the project may meaningfully impact on the lives of many patients that suffer from nlrp3mediated diseases in europe and across the globe
philosophy of dark energy

the phildarkenergy project proposes that the most dominant ingredient of our universe dark energy undermines the widely held assumption of a strict ontological trichotomy between spacetime matter and constants of nature dark energy exhibits aspects of all three categories rather than falling neatly into exactly one category the project will study the wideranging and farreaching consequences of this blurred categorisation of dark energy for major debates in philosophyin particular the substantivalismrelationalism debate about the metaphysics of spacetime and matter scientific realism vs scientific antirealism and conventionalismas well as for theory development in cosmology this project will take place at the university of utrecht the netherlands and provide the fellow dr niels martens with additional training skills and knowledge in the fields of philosophy of dark energy and philosophy of cosmology more broadly this will consolidate his academic expertise independence and networks with the goals of providing him the skills and expertise needed for a permanent academic position in the eu and playing a leading role in developing and promoting the new field of philosophy of cosmology in the eu
combining catalyst design and electrode reconstruction for industry compatible co2 electrolysis

anthropogenic co2 emission is anticipated to contribute to a projected global temperature increase of 15c between 2030 and 2052 which is associated with various environmental challenges while renewable energy sources and electrification have successfully reduced co2 emissions in some sectors air transportation without available electrified alternatives and sectors like steel and cement production that inherently involve carbon oxidation in operations must proactively take measures to mitigate their carbon footprint this entails a combination of adopting renewable fuels and employing co2 conversion techniques in the short to intermediate term the renewablepowered electrochemical co2 reduction reaction eco2rr for carbon monoxide production offers a technoeconomically feasible approach despite extensive research efforts in this field achieving economically compelling eco2rr implementation has proven elusive the primary challenges stem from catalyst performance and electrode durability regarding catalysts maintaining high selectivity under commercially relevant conditions is imperative on the electrode front enhancing both chemical and mechanical strength is essential to reduce capital expenditure to comprehensively address these challenges and with the support of the marie skodowskacurie actions the objective of this project is to integrate electrocatalyst design focused on improving eco2rr selectivity and activity with electrode reconstruction efforts aimed at overcoming flooding issues and enhancing the stability of the reaction interface this integrated approach seeks to facilitate the practical implementation of eco2rr furthermore a deep understanding of the structureactivity relationship will be attained through insitu spectroscopy and theoretical calculations the assessment of this novel strategy within this projects scope has the potential to guide the more rational development of practical eco2rr implementation
lignin and starch for tinting alternative foods

the listaf project seeks to develop biodegradable photonic materials using starch and lignin as sustainable alternatives to conventional nonbiodegradable colorants in the food industry these materials harness photonic color which offers greater durability compared to pigmentbased colors and finds applications across industries the project centers on three key work packages1 precision production of starch nanoparticles snps through enzymeassisted techniques with a focus on controlling amylopectin branching and optimizing selfassembly conditions2 utilization of lignosulfonates and colloidal lignin as surfactants to stabilize snps exploring variables such as concentration ph and addition timing to control snp size and polydispersity3 development of photonic starch and coatings for food industry applications including in vitro digestion and fermentation analyses to assess nutritional advantagesoutstanding challenges to address include overcoming snp aggregation gaining control over nanoscale starchlignin interactions and achieving closepacked assembly of the particles the project aims to address these challenges through enzymeaided research and innovative biobased surfactant systems ultimately the goal is to create ecofriendly costeffective and nutritionally valuable materials that align with consumer demand for highquality food products the successful completion of this project will provide me with valuable training in lignin chemistry and biophotonics while also enabling me to conduct groundbreaking research in the field of starch applications this comprehensive experience will expand my research expertise yield highquality publications and significantly enhance my prospects for securing a faculty position in the future
newphotonics the future of data center technologies

newphotonics is a fabless chip startup that provides an endtoend optical connectivity for the current and next generation of hyperscale data center networks est in 2020 newphotonics solves an acute problem in hyperscale data centers the growing energy consumption and capacity our solution is a highly efficient alloptic chip architecture that improves the powerhungry and costly dsp chips in optical transceivers and coreswitchesnewphotonics has filed 5 patents the all optical processing architecture achieves superior speed efficiency robustness and cost advantages a breakthrough noninvasive device for calibration and monitoring of integrated photonics circuits that is the enabler of implementation of complex photonic systems and results in higher reliability and durability our proprietary alloptical buffer and management for data package congestion mitigation in photonic switch networks ensures high throughput scalability and reliability for hyperscale data centers
borders shaping perceptions of european societies

the purpose of bshapes is to refocus on the role of borders in shaping perceptions of european societies in the 21st century confronted with the challenge of reborderings in europe borders play a key role in shaping our perceptions of societies culture heritage and belonging bshapes results will open for a reconfiguration of heritage policies replacing national approaches with crossborder european approaches to heritage empowering citizens and economic sectors to contribute to the creation of a more inclusive vision of cultures and values scrutinizing the idea of a socially and culturally coherent europe addressed in the call bshapes will use a peoples perspective to focus on rebordering as a european crisis with a negative impact on the quality of life in border regions border regions are living labs of european integration the border closures of march 2020 induced by the pandemic have severely disrupted previous attempts to develop more crossborder inclusive european perceptions of heritage and culture borders have continued to be a decisive factor shaping perceptions of us and them of culture identity and belonging therefore it is necessary to refocus on the central role of borders for the european integration project for how they influence peoples perceptions of europes historical and cultural past of heritage culture identity and belongingbshapes will apply different participatory and ethnographic methods of citizen science focusing especially on youth and minorities to collect data in different european border regions to scrutinize this challenge with the aim to develop strategies and innovative policies using more inclusive approaches to cultivate joint natural cultural and historic heritage
twinning for excellence in research training and innovation in protein misfolding diseases

protein misfolding diseases pmds are a large group of human disorders caused by protein misfolding and include serious conditions with high socioeconomic impact such as alzheimers disease systemic amyloidosis obesity cystic fibrosis retinitis pigmentosa and type 2 diabetes the vast majority of them remain incurable so there is currently a great need for the development of effective therapeutics against them among the 70 known pmds about one third occur due to the misfolding of integral membrane proteins mps mps however are notoriously difficult to overexpress isolate and study both biochemically and structurally thus constituting particularly challenging targets for therapeutic intervention with only few lead molecules in preclinical pipelines furthermore the scientific community involved in pmds remains fragmented with the majority of research targeting soluble proteins and only a small rather isolated subcommunity focusing on misfoldingprone mps the national hellenic research foundation has been exploiting the power of synthetic biology to develop efficient technologies targeting the misfolding of both soluble and membrane proteins the coordinator wishes to build on these initial successes to partner with three prominent centers in pmd and synthetic biology research in order to establish a new excellence hub in research training and innovation in pmds and consolidate the scientific community in this field through this process it will acquire a position among the leaders in the field of pmds and converge with the most advanced institutions in terms of the quality of scientific data it produces number of toptier of scientific papers it publishes amount of funding it secures from competitive sources efficiency with which it trains its young scientists and contributes to their career development the way it communicates the results of its research activity and converts them to tangible outcomes for hightech entrepreneurship and the society
single molecule reconstruction for highthroughput shortread sequencing technologies

current advanced shortread sequencing technologies and third generation longread sequencing technologies are still not capable of full molecule reconstruction in a high throughput manner due to their limited read length and throughput respectivelythis project aims at bridging the gap between long reads and high throughput by developing a fragment labelling system compatible to highthroughput shortread illumina sequencing technology the labelling system consist of tags that can be incorporated into the target nucleic acid sequences using tn5transposase and can be subsequently used to create fragments from the target molecule allowing the generated fragments to retain information of their original position in the target molecule thus the reconstruction of the sequence of the original individual target molecules from themthis technology has considerable market potential due to its relatively high ease of market entry as it can be incorporated in existing library preparation techniques for next generation sequencing since many of them readily use tn5 transposase for fragment generation additionally the ability to be able to link the short high accuracy reads generated by high throughput next generation sequencing technologies can have a large interest in the field of genomics by allowing the complete reconstruction of diploid human genomes by tackling more difficult highly repetitive genomic segments in the field metagenomics by enabling the assembly of more complete genomes from clinical samples and also in the field of transcriptomics by providing information about isoform and allelicspecific expression through the reconstruction of full length transcripts
gradual integration of renewable nonfossil energy sources and modular heating technologies in eaf for progressive co2 decrease

eaf steelmaking is the key technology for decarbonised steelmaking either in scrapbased plant by modification of existing processes for further decarbonisation or as new eaf installations in decarbonised integrated steel works to partly replace the classical bfbof production at same time the eaf is the most important example for modular and hybrid heating already now combining electric arc heating with burner technologies consequently it was selected as main focus of greenheateaf for the call modular and hybrid heating technologies in steel production greenheateaf develops and demonstrates the most important decarbonisation approaches at eafs including the use of hydrogen to replace natural gas combustion in existing or revamped burners or innovative technologies like cojet furthermore decarbonisation of eaf steelmaking by solid materials like drihbi and renewable carbon sources like biochar is tackledtechnologies to reoptimise the heating management with maximum heat recovery of offgas and slag employing new sensor and softsensor concepts as well as extended digital twins are developed as result the extended cfd and flowsheeting models and monitoring and control tools will prognose the influences of the different decarbonisation measures on eaf and process chain to support upcoming decarbonisation investments and to enable the control of decarbonised hybrid heating with maximum energy efficiency greenheateaf combines trials in demonstration scale eg in combustion and eafdemo plants with validations in industrial scale and digital optimisations with high synergy thus it completely follows the horizon twin transition and clean steel partnership objectives and the target to progress decarbonisation technologies from trl 5 to 7 this synergic concept of greenheateaf supports implementation and digitisation to speed up the transition of the european steel industry to highly competitive energyefficient decarbonised steel productio
to care or to kill when the needs of the many outweigh the needs of the few

as epitomized by epidemics and pandemics throughout human history including the ongoing sars cov2 pandemic social life carries risks of substantial and rapid spread of infectious diseases termites living in pathogenrich environments have evolved remarkably robust social immunity mitigation strategies that effectively prevent diseases from spreading within colonies individual termites carefully balance whether to care for a sick nestmate and save the colony worker resources or kill the sick nestmate to remove the risk of an infection spreading the behavioural and immunological factors driving this dichotomy remain obscure the carekill action will close major gaps in our understanding the role of pathogen dose and infection stage in governing the switch from care to kill what genes are involved in decisionmaking immune pathways neural networks genes involved in stress and how behavioural and immune memory impact carekill decision making during subsequent encounters with sick nestmates the action will capitalise on my extensive background in behavioural ecology and social immunity in termites and integrate stateoftheart pathogen load quantification and global gene expression analyses on actively caretaking or killing focal termites to establish if social immune memory is key to effective longterm reduction of disease risks in doing so this work explores novel concepts and hypotheses to close important gaps in our understanding of social immunity carekill will benefit from synergies of ongoing chemical ecology research in the focal termite species by my host michael poulsen university of copenhagen who will provide training in combining molecular techniques and termite ecology carekill will provide fundamental novel insights into the adaptive value of mitigation strategies that are essential to curb the spread of diseases and that allow for longlived animal societies to sustain in the face of pathogenic threats
carbon initiative for climateresilient agriculture

the continuous increase of the scope and the scale of the anthropogenic activities in which agriculture plays a significant role contributes to a rapid negative impact on the carbon cycle the impact of agriculture on co2 emissions will be further increased considering that the world population will reach 97 billion by 2050 eu has committed to mitigate the carbon footprint from agriculture as described in the cap objective 4 the european green deal and its flagship strategies the farm to fork and the biodiversity strategies the efficiency of these carbon footprint from agriculture strategies will be mainly determined by the synergy amongst all stakeholders policy industry academia civil society in the quadruple helix within the placebased innovation ecosystems the widening countries involved in this project cyprus greece and north macedonia as part of the balkanmediterranean region are heavily impacted by climate change to achieve these targets an inter and transdisciplinary approach is required to integrate the expertise and knowledge of all relevant stakeholders and a placebased perspective and design needsbased carbon farming solutions practices and technologies as well as strict policies to foster shifts towards a climateresilient agriculturethe main objective of this project is to establish carbonica excellence hub by connecting the innovation ecosystems of cyprus greece and north macedonia while enhancing their trl as service providers based on cuttingedge technologies earth observation eo in situ data digital agriculture etc in carbon farming the main scope is to establish access to excellence to all relevant stakeholders in the qh of the wc as well as strengthen regional innovation capacity guided by longterm joint ri strategy in the carbon farming field
redoxmediated economic critical raw material free low capex and highly efficient green hydrogen production technology

the redhy project tackles the limitations of contemporary electrolyser technologies by fundamentally reimagining water electrolysis allowing it to surpass the drawbacks of stateoftheart soa electrolysers and become a pivotal technology in the hydrogen economy the redhy approach is highly adaptable enduring environmentally friendly intrinsically secure and costefficient enabling the production of economically viable green hydrogen at considerably increased current densities compared to soa electrolysers the redhy method is based on the findings of numerous eufunded initiatives and patented by the dlr trl2 it is uniting academic and industrial entities across a broad spectrum of expertise unlike soa electrolysers redhy is entirely free of critical raw materials and doesnt require fluorinated membranes or ionomers while maintaining the potential to fulfil a substantial portion of the 2024 kpis in accordance with europes circulareconomy action plan a 5cell stack with an active surface area exceeding 100 cm2 and a nominal power of 15 kw will be developed capable of managing a vast dynamic range of operational capacities with economically viable and stable stack components these endeavours will guarantee lasting and efficient performance at elevated current densities 15 a cm2 at ecell 18 vcell at low temperatures 60 c and suitable hydrogen output pressures 15 bar the projects ultimate objective is to create a prototype validate it in a laboratory setting for 1200 hours at a maximum degradation of 011000 hours and achieve trl4 this final phase will emphasize the potential of the redhy approach and its crucial role in the upcoming hydrogen economy secure subsequent investments and showcase the necessity for groundbreaking innovative thinking to reach climate objectives in a timely fashion
beyond thalidomide the patient as an agent of change

beyond thalidomide will trace the historical rise of patient engagement with drug related disability through the second half of the twentieth century to understand how a novel empowered group transformed conceptions of reproductive health and disease in science and society the project will map the conditions in which patient became engaged with antenatal drug use and reconstruct how their action has created political and scientific urgency since 1960 this multifaceted engagement resulted in clashes of expertise that connected actors in the global south and north from latin american countries through central africa india and europe and the enforcement and stabilization of the development of approaches in reproductive health in the light of the democratic and civil societal challenges they pose beyond traditional accounts of expertled iatrogenic risk managementbt will address these aims trough analysis of four interlinked fields of patient engagement1monitoring and the surveillance of exogenous factors for birth defects2prevention and the management of risks of antenatal drug use in health care systems3marketing and the making of pharmaceutical products4legal action and court intervention mapping these fields of acting bt will create an ambitious digital collection of patient life stories and a comprehensive integrated record of how patients engage bt will or the first time deliver a global history of drug related disability from below which examines the shifting contours of patients as actors this project takes a groundbreaking approach to the historiography of reproductive health combining highimpact global case studies with innovative research tools to explore the political ethical and social challenges of this alternative perspective