Dragon09/odtu_chatbot huggingface dataset:
aipowered embryonic phenotyping for accelerated drug discovery and toxicology

the embryonetai project seeks to transform drug discovery and toxicology testing by integrating advanced deep learning technologies to automate phenotypic analysis of embryos and organoids traditional drug testing methods rely heavily on animal models which are timeconsuming costly and often ethically problematic embryonetai offers a faster more accurate and comprehensive solution for evaluating the effects of compounds on biological development thus significantly enhancing the efficiency of earlystage drug screening the core innovation is embryonetais ability to analyze complex biological data with precision providing insights into drug mechanisms that are not only quicker but also more reliable than current methods this will ultimately reduce the need for animal models in drug testing addressing both ethical and logistical concerns the embryonetai platform is poised to fill a critical gap in the pharmaceutical and biotech industries offering a scalable noninvasive approach that can be easily integrated into existing workflows with the support of the erc proof of concept grant we will focus on the further development validation and commercialization of the embryonetai platform the project will involve refining our ai models through rigorous testing building a prototype web interface for user interaction and collaborating with industrial and academic partners to ensure the platforms practical utility additionally we will explore intellectual property strategies and assess market readiness paving the way for widespread adoption by addressing the limitations of traditional phenotyping methods embryonetai aims to accelerate drug discovery reduce costs and promote more sustainable research practices in developmental biology and pharmacology through erc funding we aim to establish embryonetai as a groundbreaking tool that will impact both the scientific community and the pharmaceutical industry
valorisation of agricultural waste accesing and developing biomass subproducts for drug design

sustainability is a major concern worldwide resulting in the launch of bioeconomy as a global strategy with trillions of euros invested in waste valorisation policies agricultural waste is rich in terpenes a class of organic molecules that can be used as chemical feedstocks for the chemical and pharmaceutical industry contributing to a circular bioeconomy scheme through reduce reuse and recycle waste2drug will contribute to the agriwaste valorisation in two ways first it will focus on the valorisation of the terpenederived pisopropyltoluene commonly known as pcymene through its pharmaceutical development as a potent anticancer agent by identifying its biological target and optimizing its anticancer activity in parallel waste2drug will contribute to the optimization of the pcymene access from terpenerich biomass through theoretical investigation of the terpene deoxydehydration reaction that will aid the development of a more efficient catalytic procedure the theoretical insights provided by the researcher will be used by synthetic chemists first on model molecules and then on actual agriwaste the fellowship will be carried out at novamechanics ltd nvm under the supervision of dr andreas afantitis aa while a secondment will take place in the university of burgos ubu under the supervision of prof roberto sanz diez rsd the researcher dr sofia kiriakidi will lead the computational line of the project while gaining valuable experience in terms of leadership and project management by collaborating with experimental scientists and coordinating this multidisciplinary approach waste2drug connects theory to experiment academia to industry and promotes the eu bioeconomy strategy by both developing anticancer agents based on pcymene and by facilitating its access from biomass terpenes converting agricultural waste to novel drug molecules
metabolic interplay petween peroxisomeendoplasmic reticulum contact sites and mitochondriaendoplasmic reticulum contact sites during metabolic dysfunctionassociated fatty liver disease

metabolic dysfunctionassociated fatty liver disease mafld is the liver manifestation of metabolic syndrome consisting in a hepatic accumulation of lipids while mafld is predicted to concern near 50 of the global adult population in 2040 no medication has been developed to counter its progression recent studies have identified a novel interorganelle communication in the liver that consists in the endoplasmic reticulum engaging contact sites with both mitochondria and peroxisome hence termed as peroxisomeendoplasmic reticulummitochondria pewm complex individually mitochondriaendoplasmic reticulum contact sites mercs and peroxisomeendoplasmic reticulum contact sites percs have been described to regulate mitochondria function and peroxisome biogenesis respectively although the formation of a triorganellar complex suggests an interplay between mercs and percs this has not been evaluated yet recent report have shown that lipid metabolism regulation affects pewm complexes formation additionally mercs abundance correlates with the progression of mafld further suggesting a role of pewm complexes in mafld pathogenesis we will develop innovative percs and mercsspecific imaging probes to evaluate how changes in energy substrates availability affect simultaneously the formation of mercs and percs our second objective is to deepen the understanding of pewm complex as a regulatory hub by questioning whether and how the modulation of mercs and percs alters the function of peroxisome and mitochondria respectively furthermore we will identify the components of mercs and percs that impart their metabolic sensitivity finally we will evaluate in vivo how integrity of pewm complexes is regulated throughout the progression of mafld we will study animal models of percs deficiency to assess their interplay with mercs and their role in mafld pathogenesis this could lead to the discovery of a novel therapeutical target for treating mafld
agile ultra low energy secure networks

allegro aims at designing and validating a novel endtoend sliceable reliable and secure architecture for nextgeneration optical networks achieving high transmissionswitching capacity with 10 tbs for optoelectronic devices and 1 pbts for optical fiber systems low power consumptioncost with 25 savings and secure infrastructures and data transfers the architecture relies on key enabling innovations i smart coherent transceivers exploiting multiband multifiber technologies for p2p and p2mp applications based on eg highspeed plasmonic modulatorsphotodetectors and programmable silicon photonic integrated waveguide meshes ii lossless energyefficient transparent photonic integrated optical switches eliminating oeo conversions eg with onchip amplification in the oband for datacom applications iii a consistent approach to security in terms of functionalprotocol architectures and communications further improving qkd systems enabling optical channel coexistence and researching on quantumresistant postquantum cryptography developing systems based on physically unclonable functions and iv a scalable aiml assisted control and orchestration system responsible for autonomous networking dynamic and constrained service provisioning function placement and resource allocation leveraging devices increasing programmability and overall network softwarizationto achieve the target objectives and kpis allegro has defined a clear methodology ending in ambitious demonstrators the consortium includes a good balance of industry and researchacademia with knowhow in complementary fields the results of allegro will be disseminated in leading conferences events and highimpact journals they will have a concrete and measurable economic and social impact contributing towards achieving key european objectives reinforcing european leadership and digital sovereignty in the ongoing digital and green transition
multisite application of open science in the creation of healthy environments involving local communities

planetary health requires a better understanding of the reciprocal negative effects and cobenefits between environmental changes degradations and human health this holds at all levels local communities of low and mediumincome countries living in crossborder zones face both the negative effects of environmental changes and degradations impacting their health and well being and particular sociopolitical contexts that enhance their vulnerabilitymosaic states that these populations can be best suited to interpret and exploit complex and multithematic information about their surroundings in order to identify and understand the impacts of the environment on their wellbeing and to develop locally feasible acceptable and sustainable adaptation and mitigation solutions however usually access to information is weak and local communities do not necessarily have the required scientific literacy skills to fully benefit from itmosaic aims to design and implement open multimodal and replicable information ecosystems intended to support crossborder communities to i understand the impacts of the environment on their wellbeing ii build a healthpromoting environment iii influence public debate public policies and public decisionsit relies on the open science principles making i participatory and data sciences work together with multiple disciplines and stakeholders ii scientists and society coproduce and make use of data and knowledge with shared valuesit will consider two bioregions particularly affected by climate change extreme climatic events and land cover degradation east africa and the amazon with three crossborder study areas as laboratory sites these study sites allow for implementation and evaluation of project developments the testing of the reproducibility and reusability of methods data and tools and the facilitation of inter and transdisciplinarity through the joint mobilisation of a multidisciplinary team
bioorthogonal iontronic chemistry spatiotemporal drug release with electronic precision

i envision a new drug delivery system capable spatiotemporal release with electronic precisionthis technology is based on biontronic chemistry bc which combines bioorthogonal release br and iontronic transport to overcome the drawbacks of each individual technology and combine their unique advantages an electronic ion pump ip will enable programable electrophoretic transport of chemical triggers without liquid flow or moving mechanical parts to initiate the ultrafast selective bioorthogonal release br of drugs at the target site to generate previously unobtainable dynamic concentrationtime profiles hence bc translates electrical stimuli of arbitrary frequencies and amplitudes into tailormade biochemical concentrationtime profiles by incorporating surface release functionalities and orthogonal bioorthogonal chemistries i will further expand the concept and demonstrate choreographed cascade releases to afford individually programmable release of multiple compounds with distinct concentrationtime profiles we will map out this large parameter space using a combination of rational chemical design computationally aided device physics and engineering fluorescent model systems and finally evaluation in cell models t2s will lay the foundation for new directions in science and offer unprecedented opportunities for various therapies wherein choreographed spatiotemporal control of multiple drug release is key eg cancer nerve regeneration and aging my hypothesis is that if we combine local drug delivery and chronotherapy we can dramatically increase treatment efficacy and reduce if not completely eliminate side effects my overarching goal is to create a switch that elevates medicine to the 5th dimension 5d thus paving the way towards a paradigm shift in drug delivery and our understandingability to manipulate biologicalspacetime by delivering the right dose 1d at the right place 3d at the right time 1d
spinorbitronic quantum bits in reconfigurable 2doxides

the quest for the realization of fault tolerant quantum computation is currently challenged by the extreme fragility of quantum effects with respect to noise and decoherence quantum control quantum initialization readout and enhanced coherence remain the main challenges which need to be addressed in a scalable multiqubit platform in the last few years there were tremendous advancements in the field of spinorbitronics where the spindegrees of freedom are manipulated with electric fields through the spinmomentum locking of the electrons in spite of its importance this property of materials characterized by large and tunable spinorbit coupling soc such as twodimentional 2d oxide materials is not fully exploited in quantum computation here we propose spinorbitronics qubits and their experimental realization in single and double quantum dots based on 2d electron gases 2degs formed at srtio3based oxide interfaces due to their large spinorbit splitting and gatetunability oxide interfaces are characterized by an exceptional degree of spinmomentum locking and at the same time by a unique combination of highmobility and 2dmagnetism the exploitation of largely tunable soc and spinpolarization in 2d systems in combination with tunabilty of the host materials is very attractive for a novel quantum computation platform as it allows a coherent quantum control of individual electron spins using spin to charge interconvertion the proposed platform has all the characteristics for the practical implementation of an innovative quantum computation approach which allows upscaling to a large qubit numbers and goes beyond the onedimensional interconnect schemes with important fundamental and technological advantages based on spinorbitronics
seaweed farming 3d printed structures using new generation alternative binders a novel interdisciplinary approach from computational fluid dynamics to life cycle assessment

in march 2023 the eu parliament adopted a new carbon sink target that raises climate ambition by increasing the eus carbon sink capacity by 15 by 2030 seaweed farming has huge potential to sequester carbon dioxide but the current state of the art raises questions about the cost and environmental effectiveness of such a structure a new alternative solution of vertical marine printed algae farms made of an alternative material and with limited impact on the marine ecosystem can solve these problems the research plan based on interdisciplinary aspects combining two approaches consists of a threescale study related to computational rheology and of a twoscale investigation related to life cycle assessment the development of printing technology and a newly developed inline powderfluid mixer brings the possibility of less impactful material processing with an industrial mindset to generalise such a complex processing issue raised by alternative binders and enable topology optimised design novel numerical simulation approaches need to be developed to link experimental models with computational fluid dynamics simulations underwater 3d printing of such complex materials also raises very novel issues closely related to the opening of cracks that compromises the aesthetics and durability of 3d printed materials the goal of reducing the carbon footprint and the use of raw materials can be achieved through two strategies the first is to reduce the amount of material for a given application thanks to the 3d printing of optimised structures while the second is related to the life cycle assessment of alternative materials and to give an overview of the benefits along the entire value chain of the seaweed farming structure during its service life from ingredient production to waste management this case study raises topical issues that still need to be addressed in terms of process simulation structural design of complex structures and life cycle assessment
nanobodies to prevent hematopoietic stem cell bias and hyperinflammation

with a growing ageing population there is an imminent demand to develop new therapeutic strategies to ameliorate disorders of the hematopoietic system our innate immune system can remember its previous encounters with inflammatory triggers epigenetic memories of previous inflammatory experiences throughout an individuals lifetime are imprinted in hematopoietic stem cells hscs a small pool of bone marrow progenitors that give rise to all our blood cells inflammation harms hscs causing their functional decline and premature ageing it also causes longterm differentiation bias and a heightened basal inflammatory status known as inlfammageing the most striking characteristic of aged hscs is their increased expression of platelet and megakaryocyte markers and their commitment towards platelet biogenesis referred to as plateletbias platelet bias has important consequences to human health in our erc starting grant project platil1 714175 we discovered that platelets boost the inflammatory capacity of innate immune cells and are essential for the cytokine production of human monocytes our findings support that a dangerous combination of myeloid and platelet bias in inflammationexposed hscst results in a heightened innate immune activation the injuries to hscs are persistent and continue even after the clearance of the inflammatory insult indicating that remnants of inflammatory events accrue and prolong damage to hscs hence if we could erase these harmful remnants we could unbias hscs differentiation and prevent hyperinflammation in our ercfunded project we developed novel nanobodies that efficiently eliminate remnants of inflammation in vivo in this poc project we will test the ability of nanobodies to erase memories from previous inflammatory events and prevent hyperinflammation this project will be a stepping stone to licensing our nanobodies to industrial partners
ngi0 review

ngi0 review is a unique technical review and support hub for the next generation internet initiative open source projects funded by ngi can apply for concrete technical assessments audits and scans by experts in an open collaborative environment ngi0 review levers the proven successful ngi zero greenhouse environment where selected open source projects are supported by world class domain experts in various fields such as security accessibility license compliance standardization internationalisation etcetera the experts participating in ngi0 review provide reviews guidance and mentoring so selected ngi projects can meet important requirements and needs of internet scale using a hybrid model of paid professional services and volunteer activity the open collaborative environment allows anyone to contribute including our extensive network of open source developers data scientists cybersecurity experts standards experts user interface designers and many more organized outreach and ecosystem engagement through ict inclusivity experts like the association for progressive communication and the oldest european internet charity nlnet foundation will disseminate the output of ngi0 review to civil society human rights and consumer organisations as well as mainstream media and educational environments finally technology of selected projects can become part of the largest open source software collection currently available through the nix community which packages software to be reproducible reliable and verifiable
holographic optical tweezing bioprinting hotb towards precise manipulation of cells for artificial multiscaled vascularized tissuesorgan printing

because current limitations in 3d bioprinting for tissue engineering stem from the fact that the multiscaled vasculature associated to the human microtissues and organs cannot be replicated the overarching aim of the hotbioprinting project is to deliver a methodology enabling the manufacturing of a new generation of tissuelike structures with properties mimicking more closely the complexity of biological tissues and organs the innovation of hotbioprinting lies on the development of a disruptive technology named holographic optical tweezing bioprinting hotb for single and automatized multiple cell 3d bioprinting the noncontact nature of light will eliminate the fails on bioprinting associated to instrumentation which along with the hotb capabilities for manipulating single cells for printing will drive a new paradigm shift resolution will be dictated by the cell size instead of by the mechanical component of the instrumentation this new technological advancement for resolution enhancement while maintaining bioprinting speed using holographic automatization can open new opportunities to the tissue engineering and regenerative medicine community i propose the following general objectives that go beyond the state of the art in bioprinting human mimetic tissue1 generate the knowledge and develop a holographic optical tweezer bioprinter hotb for highdefinition singlemultiple cell bioprinting 2 demonstration and automatization for 3d multicellular printing for large area tissue generation 3 overcome the challenges associated with existing biofabrication techniques limited multiscaled vascularization and oversimplified structures4 demonstrating lymphnode bioprinting with integrated vasculature this represents a big challenge if achieved will revolutionize the bioprint technology by increasing the tissue complexity and by responding to the demand of biofabricating multiscale vascularized complex tissues and organs
commit to green participatory urban greening and renaturing towards climate neutrality and resilience in european cities commit2greenc2g

c2g supports 8 cities to move away from a projectbyproject nbs intervention approach towards the development of greening and renaturing strategies that a are crossscalar and participatory b inform existing development agendas and policies and c are implemented through demonstrators that create tangible impact on the ground for the local communities and broader ecosystem this paradigm shift is founded on the operationalisation of ecosystem services es in city decisionmaking at the district and city scale specifically c2g assesses the current supply of es in cities eg flood and heat risk reduction recreation and runs targeted engagement activities to map community vulnerabilities as perceived by stakeholders themselves these vulnerabilities translate into key placebased priorities ie the demand for es c2g works intensely to bridges this gap between supply and demand using districts as entry points considering that citizens experience life and meet their needs in this spatial scale local greening contributions can significantly improve quality of life a portfolio of projects is defined in the district scale zoomin while coherence with the broader urban fabric whether blue green or grey is maintained zoomout in this way c2g achieves crossscalar ecological connectivity ultimately each city will develop contextspecific planning guidelines and natureinclusion strategies that will be turned into design solutions for bluegreengrey infrastructure with biodiversity netgain demonstrators will apply these solutions with citizens participating along the nbs life cycle from vulnerability assessments in the early phases through to placemaking activities during implementation this innovative participation approach ensures that interventions maximise perceived value and minimize tradeoff risks eg changes in streetscape uses satisfaction assessments shall serve as a validation of the success of the codesign approach