Dragon09/odtu_chatbot huggingface dataset:
optical imaging platform for highthroughput longitudinal studies of the eye in disease models

loss of vision is frequently related to disorders of the retina that may be either primary or secondary such as involvement in metabolic or neurologic disorders since the retina constitutes an easily accessible outpost of the brain it emerged as top research target for noninvasive diagnostics of neurological diseases such as alzheimers disease preclinical testing in rodents is an essential element in the process of exploring novel therapeutic compounds the gold standard for such research and development readout relies on histological confirmation which however requires the animals to be sacrificed in contrast optical imaging methods enable rapid identification of pathologic tissue structures based on intrinsic contrast in erc starting grant optimalz we have developed a novel multicontrast optical imaging platform for longitudinal studies of the retina based on highspeed optical coherence tomography oct technology our prototype provides 3d images based on the light backscattered from the retina as well as polarization contrast for the identification of pigmented lesions and oct angiography for visualizing the microvasculature without the need for contrastagent unlike histology our platform allows for repeated noninvasive imaging of live rodents eyes and thereby greatly reduces the number of animals required for a study we have successfully demonstrated the powerful potential of our technology in rodent models of primary retinal degeneration and alzheimers disease the poc project optimeyez shall now expand our imaging portfolio to include additional models improve technological aspects and make our imaging platform accessible to key players in pharmaceutical industry by securing intellectual property developing business strategies and establishing further commercialization concepts together with users from pharmaceutical industry this project will take our technology from our lab to next generation biomedical eyebrain research
forum for emerging enabling technologies in support to the digital and green transitions through value sensitive innovations

technological breakthroughs empowered by enabling technologies hold a transformation potential that can be funneled to address industrial and societal grand challenges like greening and digitalisation to exploit this transformative potential the innovation journey that leads new emerging technologies to their marketuptake shall embed since its early valuesensitive considerations such as environmental and societal implicationswith forging we propose a new methodology based on a valuesensitive innovation journey that breaks linear innovation trajectories to stimulate new technological visions and pathways attentive to the environment and society and humancentred in alignment with industry 50 technological frameworks the valuesensitive innovation journey will be deployed in three phases the technological uncovering with tech experts from academia and industry to detect early signals of emerging technologies the societal confluence exploring the desirability and societal impact and implications of novel technologies the fullfledged cocreation opening to the broader community to develop concrete use cases for tech uptake we will develop 6 technological pathways to transfer ideas and help industry navigate through issues related to the absorption and deployment of the use casesforging methodology will be implemented by catalysing stakeholders community with 600 active members from academia to industry to css to policy makers and to the broader society we aim to organise 24 cocreation sessions consultations with 20 policy bodies 6 scenario workshops and tech and innovation campaigns to drive tech adoptionthe forging playbook and toolbox will gather a set of facilitation guidance and materials for exploration reflection cocreation and evaluation of emerging technologies these assets jointly with the forging community will sustain forging as a new flagship initiative on emerging enabling technologies
resolving sex differences in processing sensory information

mental disorders are associated with abnormal sensory information processing sip at preadolescence especially in males aberrant sip is a neutral crossdisorder trait that can be translated between humans and animals and assessed as the inability to preventgate an overload of irrelevant information the mechanisms underlying physiological and pathological sip variability are unexplored particularly the causative role of hyperdopaminergia key to sip deficits has never been tested by isolating spatially and temporally this single neural component how does this trait evolve into a mental disorder why does it occur more often in males redirect will capitalize on our rodent model of prenatal cannabis exposure pce which is the first of its kind to offer at preadolescence a sex bias in susceptibility to sip deficits upon acute exposure to stress or cannabis this animal model is amenable to molecular interrogation to probe causality for those resiliencepromoting factors preventing females from developing a hyperdopaminergia and sip deficits by combining viral strategies to trace and probe celltype specific inputoutput reorganization of dopamine circuits aim 1 with singlecell transcriptome analyses aim 2 redirect will decipher how female sex imposes distinct molecular changes to neurons and circuits which are key to prevent the etiopathogenesis of sip disorders by testing selected candidate genes to probe causality for how sex modulates genes developmental trajectories and behaviour we will decode aim 3 how discrete dopaminergic circuits can be reprogrammed sexdependentlyredirect will causally disentangle how sex differently affects genes circuits and behaviour to inform novel sexspecific and agetailored therapies for sip deficits a crossdisorder trait typical of common and severe mental illnesses including autism attention deficit hyperactivity disorder obsessivecompulsive disorder and schizophrenia
learning network for advanced behavioural data analysis

background recently there has been a paradigm shift from the isolated focus on the health impact of single behaviours physical activity sedentary behaviour sleep to the combined health effects of 247 movement behaviours technological advancements have led to wearable sensors providing rich timeseries such largescale data require novel analysis methods to provide detailed insight into the links between multidimensional 247 movement behaviour and health potential relevant subgroups and relevant behavioural characteristics to target in interventions consortium in labda leading researchers in advanced movement behaviour data analysis at the intersection of data science method development epidemiology public health and wearable technology are brought together to address this challenge aim to train a new generation of creative and innovative public health researchers with strong analytical and data science skills and a deep understanding of all aspects of wearable sensor data analysis that are able to develop innovative analysis methods and apply these in various contexts work plan via trainingthroughresearch 13 doctoral fellows establish novel methods for advanced 247 movement behaviour data analysis and assess the added value of linking multimodal data they develop a joint taxonomy to enable interoperability and data harmonisation results are combined in an open source labda toolbox of advanced analysis methods including a decision tree to guide researchers and other users to the optimal method for their research question impact the open source toolbox of advanced analysis methods will lead to optimised tailored public health recommendations and improved personal wearable feedback concerning 247 movement behaviour after the project labda fellows will be in an excellent position to pursue careers in academia epidemiology data science commercial business wearable technology consultancy or government public health policy
equestrian officers as an innovative tool for developing a middleout approach to roman imperial elites 1st3rd ad

roman society is elitist by nature and is thus represented by most available sources roman imperial elites have been long investigated however scholars usually focused only on the two extremes of elites either the top level elites employed in high imperial administration or the bottom one civic elites no attention was devoted to investigating the existence of a middleelite the riders project offers an innovative investigation of roman imperial elites with the ambitious purpose of changing traditional models of interpretation moving beyond a topdown approach ie focusing on the top level and a bottomup one ie focusing on the bottom level by developing a groundbreaking middleout approachafter over three decades since the last complete work devoted to equestrian officers the riders project readdresses the entire corpus of the 2500 equestrian officers currently known to develop an innovative tool for an indepth investigation of imperial middleelites by applying a multidisciplinary methodology based on traditional prosopography integrated with sociological methods and supported by digital humanities the riders project will develop as its main outcomes the first database devoted to equestrian officers and the first monograph on imperial middleelites the ambition of the riders project consists in applying also to elites the social concept of middle usually employed only for the remaining part of society suggesting that even elites had a middle not only a top or a bottom will ambitiously contribute to improving our knowledge of roman society which was much more complex and variegated than studies have hitherto highlighted
latin american testimonies in italy a living library between the mediterranean and the andes

the aim of the project latin american testimonies in italy a living library between the mediterranean and the andes is the collection analysis and dissemination of testimonies of latin american migration to italy during the last thirty years the study will be carried out from a gender perspective focusing on the migration of women and lgbtq people to underline cultural and literary aspects related to migration and determined by migrants intersectional conditionsin addition particular attention will be paid to testimonies by people from the andean area given their importance in italy the collection of migrant memories from a gender perspective will take place both in italy and in the area of origin of the andean migrant communities thus wanting to reconstruct the narrative of a toandfro migration the project wishes to underline the creation of an image of the migratory experience that also involves places of departure families and that in this way tells the cultural impact of migration both on the places of origin and on those of arrival overcoming a vision of migration as a linear and oneway process on the one hand and also overcoming old concepts such as those of center and periphery at a cultural level in the second part of the project the collected testimonies will be published as an online multimedia and open access anthology it will include an introduction written by the researcher and by two authors selected from among those who created the included works to recognize the subjectivity and authorship of the protagonists of the testimonies the multimedia anthology will be made available among others to language and translation students of the european american and intercultural studies of the sapienza university of rome so that they can create translation laboratories starting from it thus completing this testimonial choral and shared work
certainty in an uncertain world a philosophy of opinion

this research proposes to examine what comprises opinion in todays world of instantaneous communication how might it be said does thought lapse into opinion it is an urgent question in a time when the world with its modes of global interconnection and digital platforms is so heavily characterized by chaotic political debate and image proliferation the project aims to develop by reinterpreting select german scholarship a philosophical social and critical theory of what it means to articulate and lay claims of perspective belief and attitude within the contours of twentyfirst century social communication i will argue that a social ontology of opinion requires two distinct levels of analysis on the one hand there is a macro level whereby the broad contours and determinations of opinion are examined as inherently caught up in what theodor w adorno calls the halbbildung of industrial culture and the institution of public opinion as a development of modern society on the other hand utilizing what gwf hegel calls picturethinking there is a micro level whereby a particular epistemic structure adequate to this social situation emerges with its own patterns and forms of validation adapted to the structures of digital communication technologies together these approaches will comprise a social and philosophical reconstruction of opinion characteristic of social communication today the project can be situated within social and philosophical context whose line of investigation incorporates the discourses of epistemology cultural and political theory and intellectual history by formulating a philosophy of opinion i aim to provide vital new insight into how and why this distinctive epistemological structure of thought has become ever more pervasive in our posttruth society
development of a simulation platform to study the role of joint hyperresistance in functional tasks in children with cerebral palsy

joint hyperresistance to movement affects 85 of children with cerebral palsy cp the most common cause of physical disability in children joint hyperresistance is an important treatment target in cp yet its contribution to gait and balance impairments is poorly understood because it has been hard to associate clinical test outcomes to gait and balance deficits here we will test a novel hypothesis about the mechanisms underlying joint hyperresistance we hypothesize that the neural component of joint hyperresistance results from movement historydependent muscle mechanics and its interaction with background muscle activity and hyperactive reflexes the movement historydependent muscle force response to stretch which drives spindle firing and reflex activity might explain why it has been so hard to relate clinical test outcomes to functional impairments indeed movement history might be very different when walking than when relaxing during a clinical test however it is unfeasible to measure muscle and spindle responses to stretch noninvasively hence we will use computer simulations to test whether the proposed mechanism can explain the response to stretch in clinical tests during perturbed standing balance and during walking this requires two extensions to existing simulation frameworks first we will integrate more mechanistic muscle models in whole body simulations of movement as the commonly used phenomenological hill models do not accurately capture the response to stretch second we will account for uncertainty due to sensorimotor noise when simulating whole body movement as such uncertainty might trigger muscle stretch and maladaptive responses i will build on my own and the hosts experience to realize these computationally challenging modeling developments this project might improve the diagnosis and treatment of joint hyperresistance in cp and has thereby the potential to improve the quality of life of many individuals with cp
the bootstrap program for quantum field theory

the importance of quantum field theory qft in modern theoretical physics is hard to overstate nevertheless a proper mathematical framework to describe field theories is still lacking this is felt most concretely in the world of scattering amplitudes whose general properties are difficult to define from existing axioms this hampers our ability to make progress in understanding strongly coupled field theories in contrast for conformal field theories cfts there has been remarkable progress in recent years the key ingredient here is the operator product expansion which both significantly constrains correlation functions and whose associativity conditions can be analyzed numerically these techniques are however only suitable for theories with a conformal symmetry which normally only emerges at the endpoints of finely tuned rg flowsto advance the nonperturbative understanding of strongly coupled nonconformal qfts new methods are needed among other things it is imperative to grasp the nonperturbative structure of scattering amplitudes i propose to follow two interlinked paths based on recent results the first approach concerns the flatspace limit of a qft in a fixed hyperbolic background known as anti desitter ads space the second approach can be called the numerical smatrix bootstrap both approaches hold great promise but by pursuing them jointly i will be able to optimally leverage insights from one approach into the other
a novel radiotherapy from within platform technology for the targeted treatment of solid tumours called bat90

betaglue is developing an innovative radiotherapy from within personalized and costeffective antitumoural platform technology called bat90 bat90 maximises the therapeutic index of locoregional treatment by eliminating offtarget radiation dose in a simple and easy to use product the product aims to provide a radiotherapeutic treatment option for a range of solid tumour types including unresectable hepatocellular carcinoma hcc and locally advanced and borderline resectable pancreatic cancer pdac patients where in the firstline setting there exists a major unmet clinical need through the percutaneous administration of bat90 under radiological guidance usually ultrasound bat90 overcomes the accessibility and offtarget side effect limitations of external beam radiotherapy forms of brachytherapy proton beam radiotherapy transarterial radioembolisation and microwave ablation bat90 has already demonstrated safety and preliminary effectiveness in firstinhuman clinical studies
atomic scale quantum sensing and information with molecular nanostructures on a scanning probe tip

the ability to measure at the atomic scale quantum states and their interactions as well as fundamental observables such as magnetic and electric fields and to freely entangle and teleport quantum mechanical states at this length scale is the dream of nanoscale quantum technology yet this vision comes with the daunting challenge of combining ultimate quantum sensitivity with atomic resolution in a mobile quantum sensing and information device so far elusive for solidstate quantum systems qusint will turn this dream into reality this breakthrough will rely on a single electron spin being turned into a quantum mechanical twolevel system in a magnetic field crucially this quintessential quantum mechanical twolevel system will be brought to the tip of a scanning probe microscope to form a fully integrated and mobile spinqubit sensor capable of sensing static and timedependent magnetic fields on the atomic scale with singlespin sensitivity core of the spinqubit sensor is a single wellisolated electron in an openshell molecular nanostructure it will be fabricated in situ from single atoms and molecules on surfaces by atomic manipulation and coherently controlled by electron spin resonance qusint will foster quantum leaps in solidstate quantum technology and its many applications for example it will allow the ultraprecise characterization of quantum materials at the atomic scale transform the diagnostics of nanoelectronic devices and multiqubit systems and enable the analog quantum simulation of so far intractable manybody systems in quantum computing and cryptography it can also be used for quantum state tomography and as a transport bus to entangle remote stationary qubits and teleport information paving the way for atomicscale solidstate quantum computing with spin qubits on surfaces combining quantum sensitivity with atomic resolution qusint will unleash the quantumness of condensed matter at the most fundamental level
developing nearinfrared persistent roomtemperature phosphorescence for downconversion oleds

the continuous progress of persistent roomtemperature phosphorescence prtp emitting in near infrared nir with high potential for longlifetime and flexible optoelectronic applications is spearheaded by the development of novel materials much of this interest is also due to the concomitant advantages of the organic lightemitting diode oled technology future oled displays are envisioned to comprise an additional nir pixel for imaging and security protocols equally such nir oleds can be used as a monolithically manufactured light sources in bioimaging applications however limited by the energy gap law the majority of prtp materials emit in the visible region nir phosphors are rarely reported to solve this challenge this project aims to progress along two clear research directions i engineering efficient nir prtp emissive material systems and ii developing wellperforming persistent nir oleds to construct nir prtp material systems we will put in action work packages wps 12 by employing available organic materials to engineer hostguest emissive systems with high efficiency and stability the correlation of their photophysical properties to the molecular microenvironment will also be investigated using the stateoftheart spectroscopy methodologies to elucidate the mechanisms wps 34 will use established oled fabrication routines to develop efficient nir downconversion oled pixels with persistent emission and transfer the knowledge to an industrial rd environment the multidisciplinary project will bridge the gap between the fundamental material research of nir prtp emission and the monolithic integration of these systems in actual oleds as downconversion layers for advanced sensing applications through joint research in physics engineering and material science i can perfectly bring in my existing skills further broaden my expertise substantially and foster academic and industrial connections to build my future career network
accelerating the transition to innovative and sustainable manufacturing by an aibased software simulation that achieves firsttime right printing of lightweight and complex of aluminium alloy parts

additive manufacturing holds important promises for sustainable engineering products and applications combining the capabilities of 3d printing in terms of bionic lightweight design with the lightweight nature of aluminium and its outstanding properties could lead to a revolution in the field of sustainable mobility despite the recent advances 3d printing of aluminium alloys is a complex process that leads to many defects and a high scrap rate this becomes a cost barrier to scale the technology especially in the sectors automotive and aerospace ama proposes to develop a machine learning based toolpath with process parameters that are optimal to achieve a component defect free and firsttime right in the context of the project we will provide sciencebased life cycle analysis of the indirect impact of our technology in enabling competitive sustainable solutions to scale by reducing the cost barrier and also compare the parts before and after using our ai technology in cost quality and environmental impact criteria the technical objective will be achieved by designing a testbed demonstrator for this a specific aluminium alloy alf357 and a representative geometry from the automotive industry will be selected the ai process simulation algorithm will be trained with increasing geometry complexity once demonstrated the accuracy the model will be used to achieve firsttime right printing and avoid the traditional costly trial and errors the success of the use case will provide 1000kelvin with a unique demonstrator showing the capability of our ai based apis to solve some of the complex process challenges of the am industry this will help position our business as a leader technology provider and enhance our growth perspective to promote the role of women in leading tech startups and open the way for a more inclusive 3d printing ecosystem