Dragon09/odtu_chatbot huggingface dataset:
electronicbased systems research excellence in europe

the mission of crystalline electronicbased systems research excellence in europe is to train junior scientists jss as future leaders in electronic based systems ebss research teaming up with three austrian universities and drawing on their individual curricula the silicon austria labs sal will offer js positions in its entire ebs research portfolio scope ranging from electronic components via devices drawing on micro and nanoelectronics up to designs at the system or even system of systems level and where electronics and embedded software meet to form the technological backbone of digitalization the jss becoming full sal employees and being fully embedded into sals research environment crystalline will offer them a global picture of ebs research perspectives and connections to sals international academic and industrial innovator network for fostering their career development the research topics will be fully aligned with the regional academic and industrial technology clusters agendas with sals three sites across austria graz linz villach multiplying the options available to the jss complementing our dedication to research we will train the jss in essential transferable skills like communication project management or ethics and will offer secondments in our international network scientific forums summits social activities and networking days will be just some of the means in crystalline to propel excellence and evolution in our jss studiesin the proposed 60month mscacofund action we plan to attract 2 cohorts of 9 jss for 48month phd studies via this action we will be able to improve on our critical mass and our impact on ebs research at the highest level of scientific excellence crystalline will foster a braingain by attracting international talents to join the sal network and in turn international scientists can benefit from our sal environment that unites academic excellence with industrial entrepreneurship
photonic spectrum analyzer for the terahertz spectral domain

scientific and commercial utilization of the terahertz spectrum 100 ghz 10 thz is often hindered by the lack of affordable characterization tools for developing systems towards maturity this proposal aims for the prototype development of such tools namely affordable spectrum analyzers sa in order to boost component development in the terahertz domain 100 ghz10 thz particularly electronic and optoelectronic components these are employed in 6g hardware spectroscopy including biomedical trace gas detection security nondestructive testing and quality control to dates most employed systems are electronic frequencyextended microwave sas whilst very powerful they have a few draw backs1 it is very challenging to develop electronic systems for higher thz frequencies the highest commercial frequency extension to date goes to 15 thz2 the higher the frequency the exponentially more expensive are the frequency extenders3 the extender modules are bound to specific waveguide bands spectra larger than 50 of the center frequency can only be obtained by employing several extender bandsin phoster thz we will implement a photonic spectrum analyzer system as opposed to electronic ones with the following advantages1 spectral coverage from microwaves to several terahertz with a single system without the need of exchanging bands2 accessing frequencies yet not accessible with commercial electronic systems3 inexpensive solution a single photonic system costs less than the electronic base unit ie without extendersphoster thz emerged from the erc grant photlyze ga 713780 where the first versions of photonic spectrum analyzers were developed in phoster thz we will bring the first prototypes close to market entry together with powerful commercial partners from the photonics industry we will further aim to attract the interest of electronic spectrum analyzer manufacturers
exploring the role of copper as as a driver of vibrio aestuarianus emergence and niche specialisation as an oyster pathogen

oceans health is intimately linked to animal and human health in a one health framework marine zoonotic diseases threaten animal and human health and wellbeing ecosystem integrity and economic development of marine coastal systemscoastal waters where oysters are produced are low inerty systems highly sensitive to contaminants which can also accelerate the emergence of epidemicsepizootics and zoonotic diseases in marine ecosystems among them copper is a widespread pollutant that acts as a major selective pressure influencing microorganism survival and evolution as it can be deadly for many bacteriavibrio aestuarianus subsp francensis is an emerging pathogen that threatens european aquaculture since 2011 recent work revealed that this bacterium is an oysterrestricted specialized pathogen the ihpe laboratory has evidenced that an intimate relationship between virulence and copper resistance conferred by a pathogenicity island could be key in the adaptation of the subspecies to the oyster hostthis proposal aims to evaluate the role of copper resistance in v aestuarianus francensis adaptation to oyster and to unveil the copper resistance molecular pathways underlying this key phenotype and infection outcome specifically we will address the following questionsis copper resistance required for v aestuarianus adaptation and virulence to its hostwhat is the diversity of v aestuarianus copper resistance mechanismsdoes accumulated copper in oyster have an impact in the hostpathogen outcomeby investigating resistance to copper and virulence as interlinked phenotypes of pathogens and its impact on oyster immunity we will bring knowledge on the way copper influences the pathogensdynamics driving their evolution and specialization in marine ecosystems but also modulating hostpathogen interactions ultimately the project should help shellfish farmers and policymakers mitigate the effects of anthropogenic pollution on aquaculture services
concise consumer communication through robust labels for biobased systems

the aim of the 3co project is to develop and demonstrate viability of a supportive framework for label and certification schemes lcs on businesstoconsumers b2c communication for industrial biobased products bbps that enables and supports consumers to make more sustainable buying choices the supportive framework will consist of actionable guidelines for lcs owners that reflect consumers and other stakeholders needs digital solutions to support betterinformed decisionmaking processes of consumers as well as policy recommendations on deploying social measures in terms of approach 3co will i assess the lcs and metrics in the bioeconomy ii iteratively engage consumers to understand their decisionmaking processes and motivation towards sustainability consumption and needs and requirements towards future labelling of bbps iii codevelop smart digital solutions for consumers to support their behavioural change towards responsible consumption iv assess measures for social engagementinnovation supporting consumers industry and public bodies to switch towards socially and environmentally responsible behaviour and v create guidelines for the design of labels for bbps for owners of environmental labelling and information systems public authorities and industry designers the project aims to improve the sustainability performance and competitiveness in the biobased systems impact of the 3co project will include i improved transparency of bbp value chains and information to consumers and public authorities through digital solutions ii support of environmentally responsible decisionmaking through lcs iii improved understanding of metrics on environmental societal and economic value generated by bbps and as a wider impact iv innovative governance models 3co will help to increase the market share of sustainable circular bbps influencing the business of companies that make and offer these
healing and learning in the fondaco a forgotten network of knowledge in the eastern mediterranean and the mamluk and ottoman levant 14001700

this twoyear fellowship will produce the first systematic study of an uncharted network of knowledge exchange connecting christian and islamicate states across the mediterranean and levant 14001700 this network had its humble origin in a public health initiative of the republic of venice first uncovered by pugliano thanks to a wellcome trust fellowship in medical history keen on protecting its commercial and political interests overseas for three centuries venice appointed physicians surgeons and apothecaries to its colonies and outposts in the mamluk sultanate and the ottoman empire tasked with guarding the health of venices diplomats and merchants in fact these medical servants used their positions as springboards for rich intellectual explorations that brought them in contact with local populations and traditions the proposed project aims to investigate how these diplomatic doctors turned into savants and more ambitiously how this network facilitated the development of key fields of scholarship in early modern europe notably natural history and antiquarianism and how these were informed by the intellectual world of the near east in so doing the project will overturn the image of intellectual stagnation traditionally attributed to the postmedieval mediterranean world and reshape our understanding of the connected history of the region the project will significantly contribute to the development of the field of history of science and medicine in the host institution and european higher education it will also considerably advance the career of valentina pugliano an experienced researcher educated internationally in the uk germany and the us the training provided by ca foscari and a secondment at koç university istanbul the international networks of these two institutions and the projects output will cement puglianos reputation as emerging scholar and increase her chances of securing an erc grant and a position at a european university
programming platform for intelligent collaborative deployments over heterogeneous edgeiot environments

p2code envisions the design and development of an open platform for the deployment and dynamic management of end user applications over distributed heterogeneous and trusted iotedge node infrastructures with enhanced programmability features and tools at both the network infrastructure level and the service design and operational level the platform is implemented following three innovative design approaches i the deployment and management of the applications is conducted by an orchestration framework that follows a vertical layered approach from the end user interface to the infrastructure management while spanning horizontally across the deviceedgecorecloud continuum the deployment follows the userdefined networking and operational features of the application in its northbound interface and a tight integration with stateoftheart iot edgecloud computing and networking platforms in its southbound interface through a welldefine driver api framework with this approach the full programmability and reconfigurability of resources across the continuum is enabled ii an open and extensible programming toolset facilitates application development and deployment for large swarms of devices at the edge through a multirole internal developer platform idp and new feature development and testing iii a secure and trusted framework for registering and authenticating iot device and edge nodes entering the system as well as the data sharing and application deployment the concept is tested and validated over a mature testing environment that integrates diverse iot application areas in smart logistics manufacturing utility inspection and community ppdr over a programable infrastructure extended to oran 5g sdn enable core cloud the consortium addresses all the required development sectors from the platform technology innovations to supported iot infrastructure and applications including the end user interfacing and resource management intelligence
new trends or old habits stability and changes of political styles since 1960

hardly a week goes by without reports of elected officials often pictured as populists having used vitriolic language and attacked the personal traits of their opponents in a context of restyling of politics the style of political actors is presented as increasingly emotive personalised and confrontational in the absence of systematic comparative study such claims remain however trivial intuitions and anecdotes that are as old as politics this raises critical questions are modern political styles new trends or old habits what are the institutional and political factors that constrain or favour the rise of certain stylesthe polstyle project provides a groundbreaking empirical and theoretical contribution by analysing the evolutions of political styles in four european democracies since 1960 it posits that configurational evolutions shape the stability and changes of political styles over time it depends upon the varying responses of the types of actors arenas and political systems visvis abrupt exogenous shocks and endogenous incremental changesfor these empirical and theoretical goals the project builds a unique dataset of actors political styles performing in various arenas tv print press parliaments and twitter different indicators will trace evolutions of political styles in terms of contents nature of interactions and forms of expressions finally the project develops a theory that explains how and why patterns of styles unfold according to configurational evolutions overall the polstyle project decisively contribute to ongoing theoretical debates about the nature of political representation in modern democracies and how democratic linkages with voters are built on a daily basis while some scholars and political observers suggest that current political styles entail nothing less than the inexorable decline of democracy other scholars have praised them as virtues for the functioning of our democracies
harnessing the splicing code for targeted control of gene expression

alternative splicing as of mrna precursors plays important roles in tissuespecific gene regulation and biological regulatory mechanisms as it can radically alter protein expression cell phenotypes and physiological responses altered splicing also contributes to disease mechanisms ranging from neurodegeneration to cancer drugs modulating as have recently provided the first therapy for spinal muscular atrophy a common genetic disorder illustrating the huge potential for treating many other diseases of unmet need if only we understood the mechanisms controlling splice site selection and how to regulate them with small molecules unfortunately despite decades of research a comprehensive understanding of the mechanisms that control specificity of as is lacking this gap in basic knowledge prevents opportunities to harness splicing modulators as tools to study gene function novel therapeutics or other biotech applications this project addresses headon the major technical challenges that have limited progress in the as field building on extensive preliminary data we will use a multidisciplinary approach that combines chemical structural cellular systems biology and machine learning to characterize mechanisms of splice site selection and identify targets for modulating these mechanisms using tool compounds the outcomes will define key regulatory sequences splicing factors and molecular interactions involved thereby illuminating how the splicing machinery efficiently accommodates yet also discriminates between a wide range of splice site sequences this will enable future applications harnessing splice site selection our primary goal is to answer the central question is it generally possible to modulate splicing with high specificity using small molecules success will transform our basic understanding of human gene expression and unleash major opportunities for pharma to develop new therapeutics
interoperable opensource tools to enable hybridisation utilisation and monetisation of storage flexibility

storage is becoming one of the most critical assets for modern energy systems at the same time storage is a very diverse universe of solutions and technologies with very different characteristics interstore plans to address this complexity by developing an innovative middleware that while virtualising the storage technology will simplify its use from the point of view of integration platform thanks to a technology agnostic approachthe middleware will facilitate the integration of storage creating an independence from hardware solutions which are critical from customer perspectives to avoid vendor lockin solutions it will also facilitate its use from a monetisation perspective making sure that more investments in storage are enabled interstore middleware will be released as a full opensource product integrating a set of already available standards and protocols in a coherent and advanced architecturethe new interstore solution will be tested and validated in a laboratory environment with the goal to develop testing software to be adopted in the future for interoperability certification the middleware solution will also be integrated both in open source and commercial platforms that will be integrated in 4 real life demos to enhance the flexibility platforms and analyze the user acceptance and economic value of the new solution moreover new and legacy systems will be taken into account interstore also has a strong focus towards impact the solution will become part of existing commercial platforms ensuring that a real adoption will be deployed beyond the end of the project the consortium will ensure that software maintenance will continue beyond the end of the project with the support of linux foundation energy and that the work done will be considered by ongoing standardization activities ssh experts will perform an impact analysis to maximize the economic impact adopting innovative approaches to data monetization in the context of data spaces
influence of climate variability on the gravettian cultural diversity and evolution

currently facing major environmental changes due to global warming a growing concern of modern societies is related to how we will be able to cope with these rapid changes to survive this kind of preoccupation is probably not new over the course of its history the human species has been able to adapt to very different environmental conditions thanks to diversified cultural adaptations the objective of the project climdive is to understand the role of environmental change in the diversity and evolution of cultural adaptations at large geographic and chronological scales using the archaeological record of the gravettian 3226 000 years before present as an example framework at this period archaeologists have shown that two neighboring regions western and central europe exhibit very different cultural trajectories without being able to understand the largescale mechanism that influenced this pattern the climdive project aims to explore the factors composing this mechanism by integrating archaeological data and paleoclimate simulations into a unified approach ecocultural niche modeling this approach derived from the field of distributional ecology allows one to identify the environmental conditions associated with specific cultural traits to do so dr vignoles will gather pertinent archaeological occurrences and environmental variables for the central european gravettian these data will feed a mathematical model that represents the niche these results will be compared with her previous work on the western european gravettian based at lige with shorter stays in kansas university and parissaclay the research will be supervised by three internationally recognized researchers specialized in the gravettian ecology and paleoclimatology the proposal will result in a model underlining different types of factors environmental cultural demographical probably implicated in the separate evolution of neighboring regions during the gravettian
artificial intelligencebased decision support system for risk stratification and early detection of heart failure in primary and secondary care

heart failure hf is a pandemic currently affecting up to 15 million people in europe it is a complex clinical syndrome presenting with impaired heart function and is associated with poor quality of life for patients and high healthcare costs there is a high clinical demand for novel artificial intelligence ai tools which will facilitate risk stratification early diagnosis and disease progression assessment in hf such tools are essential to allow prompt initiation of evidencebased prevention and treatment strategies which will improve patient quality of life reduce morbidity and mortality and the hf burden on healthcare stratifyhf aims to develop validate and implement the first aibased decision support system dss for risk stratification early diagnosis and disease progression assessment in hf to accommodate both primary and secondary care clinical needs the dss will integrate patientspecific demographic and clinical data using existing and novel technologies and establish aibased tools for risk stratification and hf prediction using machine learning additionally a mobile app will be developed to empower patients to better manage their condition and health care professionals to make informed decision in selection of evidencebased hf prevention and treatment strategies our multidisciplinary consortium including three smalltomedium enterprises smes and two stakeholder organisations will be guided by medical advice and regulatory and health technology experts to deliver the dss as a medical class 2b device reaching trl 8 by the end of the project startifyhf will change the way in which hf is diagnosed today and thereby improve the quality and length of patients lives and lead to efficient and sustainable healthcare systems by reducing the number of hfrelated hospital admissions and unnecessary referrals from primary to secondary care in europe and beyond
idefix multiorgan toxicity and efficacy test platform

to address the critical problem of the failure of animal testing to predict drug effects toxicity and efficacy in humans cherry biotech develops a breakthrough organonchipmps solution based on microfluidic technology using human tissue our idefix technology mimics multiorgan physiology and physiopathology our mps platform aims to be the new standard as an alternative to animal experimentation in preclinical studies indeed our solution succeeds in tackling all major industry bottlenecks seamless adaptability to current workflows compatibility with all standard multiwell cell cultures and tissues as well as full microenvironment control and measure while providing a stateoftheart reconstruction of complex tissues vascularisation immune system circulating metastasis multiorgan interconnection this is now achievable by combining the patentpending gas mixers technology fr2109230 trl3 coming from h2020fetopen project electromed with cherry biotech proprietary microfluidic technologies in gas enrichment and simultaneous liquid flow ep3712244 fr3094012 us2020299631 and our unique knowhow in tissue engineeringwithin the transition project the idefix demonstrator will be completed as a modular platform with stackable modules gas flow temperature biosensing microscopy imaging control allowing users to customise the platform according to their respective needs and budget the final qualification will be conducted in relevant environments with two european pharmaceutical companies and a hospitalresearch centre using vascularized liver adipose and breast cancer tissues we will test our models to predict the efficacy and toxicity of various known molecules and compare them to previous preclinical animal experimentations and clinical results retrospective study by the end of this project the idefix demonstrator will reach trl6 be investmentreadyirl7 and be prepared for precommercialisation to early adopters