Dragon09/odtu_chatbot huggingface dataset:
circadian regulation of tanycytes its role in the regulation of rhythmic physiology in health and in circadian misalignment

the suprachiasmatic nucleus scn of the brain our internal clock synchronizes physiology to the earths rotation using signals from the environment such as light and food intake however in industrialized cities these same signals at wrong times uncouple the internal clock from the environment leading to circadian misalignment such as in night and shift workers who have elevated risks of developing obesity and metabolic syndrome nevertheless effective measures to delay or limit health costs for these people are yet to come recently i described novel vasopressinergic scn neuronal scnavp fibers in the vicinity of nonneuronal hypothalamic cells known as tanycytes that have the ability to sense and transport metabolic cues whether the sensor and transporter functions of tanycytes are regulated in a circadian manner by the scn and whether this regulation plays a role in the development of metabolic impairments during circadian misalignment are unknown thus in the circanycyte project we will seek to 1 determine how scnavp neurons control tanycytic function 2 explore the role of scnavp neurontanycyte communication in circadian alignment and metabolic fitness and 3 determine the contribution of scnavp neurontanycyte miscommunication to the development of metabolic syndrome during circadian misalignment to accomplish these aims i will undergo training in cuttingedge technologies eg ca2 in vivo imaging of tanycytes with simultaneous optogenetic manipulations while i exercise my leadership and management skills by working in a top laboratory using the experience as a launching pad for international collaborations in frontier science in the eu my original angle of research hypothesizing that tanycytes which extend processes outside the bloodbrain barrier are key targets of the scn to regulate metabolism is a strategic choice that promises to uncover new actionable pharmaceutical targets to fight desynchronizationrelated disorders
drug optimisation in lmics of pregnant hiv women and their infants temporary switch to cabrpv long acting injections

sustained art use is essential for achieving sdg3 by reducing hiv burden and promoting maternal and infant health ensuring consistent adherence and engagement in care is crucial to achieving unaids 959595 viral suppression targets in treated individuals by 2030 despite arts success low adherence presents a significant barrier to maintaining longterm viral suppression challenges are notably heightened in postpartum wlhiv as transition into motherhood introduces a range of changes and stressors that can significantly impact adherence therefore theres an urgent need to prioritise interventions enhancing engagement and promoting adherence inorder to achieve viral load suppression and prevent mother to child transmission dolphin3 aims to operationalise an implementation project using a mixed methods approach to generate evidence on optimal use of longacting injectable art as a strategy to improve adherence rates and overall health outcomes among postpartum women in south africa and uganda the projects objectives are to i establish effectiveness of a temporary switch to cabotegravir cabrilpivirine rpv la as a bridging strategy during breastfeeding ii explore strategies to safely reestablish oral art after discontinuation of cabrpv la iii explore maternal infant and breastmilk pharmacokinetics and iv engage with stakeholders to generate insights for sustainable future deployment of lai the dolphin consortium possesses a proven track record in conducting clinical trials specifically in the population of women initiating art late in pregnancy our proposed project aligns with the edctp3 broader objectives of evaluating the reallife impact of existing interventions in women and childrens health and improving maternal neonatal and child health in subsaharan africa our proficiency in implementation research empowers us to transform our research findings into practical recommendations for healthcare systems and policymakers
a breakthrough technology designed to preserve sight and halting vision loss associated with a range of retinal disease by preventing the death of key retinal cells

i am the ceo and cofounder of seabelife a french biotechnology company developing firstinclass drugs to treat severe pathologies affecting our vital organs for which there are no effective treatments we develop an innovative therapeutic approach protected by 4 patents and with a lead program to treat acute liver failure and a second program to preserve sight and halting vision loss associated with a range of retinal disease by preventing the death of key retinal cells we are developing a firstinclass drug based on a dualtargeted approach capable of stopping directly and simultaneously two forms of regulated cell death pathways known to be involved in triggering of numerous acute and chronic pathologies and contributing to organ damage our molecule protects the cells prevents tissue damage and finally preserves and restores organ function seabelife is the only company worldwide developing such a therapeutic approach our molecule has a direct protective effect on cells and has the potential to prevent evolution to severe lifethreatening form we have already obtained very convincing in vivo results in several highly predictive models our molecules were tested on pharmacologically relevant murine models and have shown no toxicity and strong efficacy seabelife is composed of an experienced and complementary operational team managing by two women and supported by a scientific and strategic advisory board with scientific and medical experts of extensive expertise in drug development we have already raised 43m to develop our technology and we are ready to bring our molecules to the clinic and validate its safety and efficacy the main milestones over the next 2 years will be the production of compliant clinical batches and the realization of phase 1 and phase 2a clinical trials the womentecheu award and funding will allow us to gain visibility as women entrepreneurs and also to take an important step in our preclinical development for eye diseases
untangling the biologic and social causes of low fertility in modern societies

highincome countries are experiencing both unprecedentedly low and increasingly polarized fertility with growing social gradients in childbearing key theories on fertility patterns are based on the empirical observation that until recently fertility remained comparatively high in genderegalitarian countries with strong support for families since 2010 many of the countries that provided evidence for such theories have reached recordlow fertility this confronts the scientific paradigm of the key drivers of fertilitybiosfer investigates how social biological and psychological factors work together to produce the observed patterns levels and variation in fertility among young adults and to what extent the fertility decline and the related polarization can be attributed to social vs biomedical factors our multitheory approach leverages ideas from several disciplines and proposes that the existing theories must be complemented with concepts of risk aversion and information intergenerational transmission of fecundity epigenetics and beyond in order to understand modern fertility behaviour we develop theoretically informed falsifiable hypotheses that we test against the two richest populationbased longitudinal pregnancy and pubertal cohorts in the world moba in norway and the dnbc in denmarkwe offer a uniquely integrative lifecoursebased approach that is neither social or biomedical but combines central ideas from both and evaluates the biosocial determinants of the key transition points from fetal life through puberty and partnering into planned unplanned partnered and unpartnered childbearing we study the social biomedical and psychological forces their interactions and intergenerational forces as they operate throughout the lifecourse to produce the modern lowfertility landscape the results will help to provide a novel biosocial framework for understanding the lifecourse processes that drive contemporary fertility patterns
breakthrough technology for plastic and rubber waste circular tpe

plastics and rubbers are broadly used to produce different products unfortunately their waste does not degrade and remain in the environment an increasing amount of generated plastic and rubber waste requires suitable methods for their recycling one of the greener applications of both materials is to use them in the production of thermoplastic elastomers tpes however made in this simple but inefficient way tpes show poor mechanical performance as a result of incompatibility of polymer blends hence their applications in industry are very limitedat ecopolplast we have created a process that allows mixing recycled scrap tyres with postconsumer plastic creating circular ecoplastomers tpes that are the greenest tpes available globally made exclusively of discarded recycled plastic and recycled tyre rubber and without any chemicals and additives we have confirmed that our technology works trl 6 and now need eic accelerator support to scale up the technology
advanced structure preserving lagrangian schemes for novel first order hyperbolic models towards general relativistic astrophysics

alchymia will make substantial progress in applied mathematics targeting longtime stable and selfconsistent simulations in general relativity and high energy density problems via the development of new and effective structure preserving numerical methods with provable mathematical properties we will devise innovative schemes for hyperbolic partial differential equations pde which at the discrete level exactly preserve all the invariants of the continuous problem such as equilibria involutions and asymptotic limits next to fluids and magnetohydrodynamics key for benchmarks and valuable applications on earth we target a new class of first order hyperbolic systems that unifies fluid and solid mechanics and gravity theory this allows to study gravitational waves binary neutron stars and accretion disks around black holes that require the coupled evolution of matter and spacetime here high resolution and minimal dissipation at shocks and moving interfaces are crucial and will be achieved by groundbreaking direct arbitrarylagrangianeulerian ale methods on moving voronoi meshes with changing topology these are necessary to maintain optimal grid quality even when following rotating compact objects complex shear flows or metric torsion they also ensure rotational invariance entropy stability and galilean invariance in the newtonian limit the breakthrough of our new finite volume and discontinuous galerkin ale schemes lies in the geometrical understanding and high order pde integration over 4d spacetime manifolds the highrisk highgain challenge is the design of smart dg schemes with virtual boundpreserving genuinely nonlinear datadependent function spaces taking advantage of the voronoi properties finally it is an explicit mission of alchymia to grow a solid scientific community sharing knowhow by tailored dissemination activities from toplevel schools to carefully organized international events revolving around personalized interactions
the doctoral rift science network for the energy transition

talents is a european based research network aiming to train early career researchers with the interdisciplinary sciencedriven understanding and skills that are the foundation to develop new sustainable solutions for the global challenges of the energy transition our joint research focuses on continental rifts which are key regions for geothermal energy carbon capture and storage for new resources such as native hydrogen as well as highrisk human habitats due to geohazards such as earthquakes and volcanic activity we believe that only if we better understand the natural process chains that shape rifts and passive continental margins by investigating key natural laboratories characterising rift initiation east african rift rift maturation gulf of corinth in greece central european rifts and continental breakup west iberian margin we will obtain key knowledge for a safe and sustainable exploration for new carbon free energies talents fuses research and training at 18 beneficiaries and academic partners that are among the world leaders in the study of rift systems and 11 companies that are actively involved in the energy transition the 12 phd projects address fundamental scientific aspects of rift system processes collectively bridging several orders of magnitude of spatial and temporal scales each doctoral candidate is linked to 1 an academic partner to complement and broaden their scientific training 2 to a dedicated industry partner to acquire industryrelevant skills and preview possible nonacademic career paths and 3 to a media contact to actively train in communicating their science to the public training by research and interaction will be complemented by various forms of education spanning a wide range of topics to develop scientific and professional skills to establish ethical standards and to widen career perspectives
past and future highresolution global glacier mass changes

worldwide glaciers are losing mass which affects global sealevel river runoff freshwater influx to the oceans glacierrelated hazards and landscape changes with implications for human livelihoods and ecosystems hence accurate estimates of past current and future glacier mass variations at a high temporal and spatial resolution are key to effective adaptation strategies however previous massbalance reconstructions and projections have relied on scarce observations with limited spatial andor temporal resolution as well as overparameterized insufficiently constrained and highly simplified models the latter necessitated by high computational costs incurred by the global scaleglacmass will propel the current stateoftheart of globalscale glacier reconstruction and projection forward in unprecedented ways by delivering a fundamentally novel and internally consistent physicallybased modelling framework that draws for the first time on a global scale on both data assimilation and modern machine learning techniques facilitated by emerging globalscale glacierrelated satellitederived data the framework will be used to reconstruct multidecadal past glacier changes and make policyrelevant multicentury projections of mass and area changes of all 200000 glaciers outside the ice sheets with unprecedented accuracy spatiotemporal detail and computational efficiency and also nowcast present mass changes in a nearrealtime fashion for selected regions the model framework will fuse output from a novel physicallybased glacier evolution model with all relevant observations available for each glacier such as insitu geodetic and gravimetryderived mass balances as well as snowlines and other observations thus simultaneously exploiting the untapped strengths of different types of observational data sets in an optimal manner
cytokine and microbiota function in gut development spatiotemporal analysis in the zebrafish

organ development and function are controlled by complex interactions between genetic cellular and environmental factors because these interactions are challenging to study in live organisms their mechanisms remain largely unknown gut development is regulated by microbiota colonization making it a valuable organ for dissecting geneenvironment interactionscytokines small secreted proteins highly responsive to environmental changes regulate immunity and gut function in mammals our data indicate that specific cytokines are also essential for gut development in zebrafish we found that these cytokines are first expressed in gut epithelial cells during development and later their expression is switched to immune cells including innate lymphoid cells ilcs ilcs were discovered in the mammalian gut but their function has not been dissected due to the lack of specific markers having identified the first vertebrate ilc markers in zebrafish we will combine our novel tools together with other unique benefits of zebrafish such as live microscopy easy environmental manipulation and abundant genetic tools to dissect how microbial cues interact with genetic networks to control organ development we hypothesize that gut development is regulated by cytokine signaling that is in turn regulated by crosstalk with the microbiota and the emergence of ilcsour specific aims are to1 characterize the roles of cytokines during gut development2 determine how microbiotacytokine crosstalk controls gut development3 uncover the role of ilcs and cytokine source switching in gut maturationthis project at the intersection of developmental biology and immunology will provide fundamental insights into how symbionthost crosstalk controls organogenesis and a new conceptual framework for the function of the immune system furthermore conservation with the human gut could help identify new therapeutic strategies for common diseases such as inflammatory bowel disease
diagnostic screening platform to facilitate conflict resolution

multidoor is a digital platform based on conflict resolution and machine learning expertise to address the comprehensive needs of litigants and recommend their best way forward to resolve their disputes at present litigants attempting to navigate through the civil justice system end up drifting through an incoherent opaque process generally resulting in some form of reluctant compromise while court systems worldwide are investing much effort to increase efficiency a humancentred approach which takes into account litigants needs interests and emotions is lacking multidoor employs an innovative intake screening recommendation system to integrate each litigants or potential litigants specific needs interests and emotions the features of the case and the predicted case trajectory in the legal system resulting in a diagnostic recommendation eg mediation arbitration adjudication outofthebox solutions we describe the activities needed to develop a beta version of multidoor including conceptual framing and validation the activities include a crowdsourcing experiment to accumulate data on users satisfaction with conflict resolutionoriented processing of their disputes developing forecasting models for user satisfaction and developing a machinelearning based recommendation system multidoors benefits include 1 developing a new domain of conflict resolution machine learning via collaboration among data scientists and legal and conflict resolution experts 2 advancing a personalized conflict resolutionoriented response to disputes including to small nonlitigable disputes 3 promoting public trust and social wellbeing by ensuring that parties including those from disenfranchised sectors are informed and supported to selfdetermine how to resolve their disputes 4 answering the current drawbacks of online dispute resolution odr systems which focus mostly on legal issues rather than on the interests of the parties
contested conditions in the wake of covid19 relations between autobiography media and illness

autobiographical narratives about contested conditions have been published in western media which often highlight personal experiences of dismissal in health care and public scholarship in medical humanities argues that illness narratives can give voice to affected communities and provide evidence of the experience of illness and disability this approach emphasizes the performative power of personal storytelling and the need to witness but risks to promote a reading of autobiography as a social good rather than as a complex mediated and cultural practice specifically what is insufficiently accounted for is the role of mediality and materiality in autobiographical practices and politics of chronic illness my project is a nuanced study of autobiographies of two chronic conditions long covid the continuous illness after an infection with covid19 and the chronic condition of myalgic encephalomyelitis or chronic fatigue syndrome mecfs are contested and debated in polarized ways in contemporary biomedicine and culture leading to stigmatization and reduced quality of care for those affected i closely examine a selected number of emerging autobiographical forms such as collective storytelling virtual exhibition and artistic microblogs which have been published in germany and in the us 20152023 by analyzing new strategies of communicating illness experience i ask how these media forms and material practices affect and are affected by politics of chronic illness and disability i will integrate a wide variety of methodological approaches from media studies and concepts from disability studies and medical humanities to claim that closely examining mediated and material practices of autobiography opens overlooked relations between illness media and politics that are obscured by the focus on representation the project aims to reframe autobiography within questions of stigmatization and inequality and to reconsider how autobiography is conceptualized and approached in medical humanities more generally combined with innovative approaches of public engagement the project seeks to impact the cultural bias against unexplained illness and to expand my transdisciplinary research expertise at the intersection of cultural studies and medicine
inclusive and interconnected ecosystem to boost paediatric innovation in europei4kidseurope

innovation in paediatric health is critical to ensure that children regardless of their age health condition socioeconomic situation or place of birth have access to the lifechanging healthcare solutions they need to growup stronger and contribute to a better society children are not just small adults and they need targeted innovative solutions however paediatric innovation is still elusive there are two main causes for thisi stakeholders perceive paediatric innovation as risky and they just try to adapt adult solutions to childrenii paediatric experts innovators and other relevant stakeholders are scattered in a fragmented ecosystem across europe failing to identify opportunities or deliver effective and harmonized actionthus the unexploited innovation potential is large particularly in emerging and moderate innovator countries to reduce barriers and exploit these opportunities while ensuring equality across different countries the establishment of a european paediatric innovation ecosystem is of paramount importancethe i4kidseurope project builds on an existing successful initiative i4kids and it will expand its activities towards europe in order to enlarge the participation of diverse european paediatric stakeholders and territories the project will allow synergies avoid duplications reduce differences between strong and emergingmoderate innovator territories and strengthen competitiveness to optimise the innovation potential of the european paediatric sector to achieve this we will analyse the landscape of paediatric innovation in europe as well as the barriers that emergingmoderate innovator countries face i4kidseurope will offer an interconnected paediatric innovation ecosystem that will capacitate its underrepresented actors and make them participate in the design of the future european paediatric innovation ecosystem