Dragon09/odtu_chatbot huggingface dataset:
mathematical models for coral reefs towards an interdisciplinary and conservationfocused research

coral reefs are one of the most biologically diverse ecosystems on earth but their regression has largely increased in the last decades due to local human pressures and global warming this project aims to use numerical models and simulations to expand our understanding of coral reefs dynamics and improve marine conservation strategies i will follow an interdisciplinary approach using complex systems and nonlinear physics techniques combined with ecological knowledge and field data of coral reef systems my results will be the foundation to study a large variety of open questions in coral reef science using an innovative and groundbreaking point of view in this project i will focus on two applications of the models i the study of the underlying mechanisms causing the emergence of halolike patterns around reef islands grazing halos and ii the construction of a protocol to optimize and reduce costs in coral restoration programs i expect my results to have a high impact on the scientific community and contribute to making better and more informed decisions about the sustainable management of coastal zones in line with the new eu biodiversity strategy for 2030 a comprehensive ambitious longterm plan for protecting nature and reversing the degradation of ecosystems aiming to put europes biodiversity on a path to recovery by 2030 with benefits for people the climate and the planet
dissecting the role of sperm transcriptome dynamics in intergenerational inheritance through native rna nanopore sequencing

mammalian sperm rna is increasingly recognized as an additional source of paternal hereditary information beyond dna environmental inputs such as diet and stress can reshape the sperm rna signature and induce offspring phenotypes that relate to paternal environmental stressors however how when and to what extent sperm rna populations change and what is the role that rna modifications and other posttranscriptional regulatory layers play in shaping sperm rna dynamics remains poorly understood here we propose to characterize the dynamics of rna populations during sperm formation and maturation using native rna nanopore sequencing this technology is suited to provide an integrative and comprehensive view of the transcriptome epitranscriptome degradation patterns and tailing dynamics simultaneously and with single molecule resolution we will establish novel library preparation methods that can capture the full sperm epitranscriptome and will capitalize on our recently developed algorithms to map and quantify rna modifications in individual rna molecules we will then apply these methods to reveal how paternal dietary exposures affect sperm rna populations and the metabolic phenotypes of their offspring and test whether the novel identified rna candidates can transmit dietinduced paternal phenotypes to the subsequent generation finally we propose to expand our previous work on direct rna multiplexing to establish single cell direct rna nanopore sequencing to characterize the diversity and heterogeneity of the sperm rna epitranscriptome at an unprecedented single cell and single molecule resolution
derisking the drug discovery process of oncology and metabolic diseases

excellence vitala technologies brings together organonchip ooc hyperpolarized magnetic resonance spectroscopic imaging hp mrsi and advanced data analysis tools to provide a patented and revolutionary test for the monitoring of the efficacy in treatment of a new drug moving through the metabolic pathways of a cell this new methodology provides the opportunity to set preclinical drug testing strategies that are more effective faster cheaper and reduce animal use the information obtained by this novel methodology will improve the future steps for drug candidates in advanced preclinical and clinical stages vitalas analysis allows defining and executing on preclinical testing strategies increasing the speed of the drug discovery process and reducing its costsimpact an increased accuracy in the early stages of the drug screening process will allow discarding inadequate pharmaceutical candidates before those reach the animal testing stage reducing the number of animals used in the whole preclinical process moreover our objective is to derisk and revolutionise the entire drug discovery process decreasing the direct and indirect costs associated with the preclinical drug discovery pipeline with our realtime nondestructive highly sensitive technology vitalas impact will expand to later phases of drug discovery by preventing invitro and in vivo as well as human testing of drugs that in the absence of translatable models could have been deemed appropriate to proceed to later clinical trial stagesimplementation and team vitala is formed by a management team of professionals with complementary backgrounds in the fields of microfluidics imaging technologies and business administration vitala has already filled a pct patent application and successfully completed an fto which gives our technology a green light to be exploited both in the eu and the usa with short and long term strategies in place
waste heat to energy

to cope with the growing global energy consumption and sustainable development scenarios waste heat recovery is an efficient green and economic solution to help highly demanding industries save valuable energyhowever while low grade waste heat 100 constitutes the largest source of heat with an annual 3700mtoe corresponding to 63 of the total recoverable heat it has not been widely exploited yet due to technical and economical difficulties only valorisation of high and medium grade in the form of electricity is largely deployed at industrial scalein the wh2e project sweetch energy is proposing an innovative way to convert low grade waste heat into electric power to do so two major steps will be necessary the conversion of temperature gradient into salinity gradient using thermosensible ionic liquids coupled with an osmotic engine inod to generate electric power as final output the inod ionic nano osmotic diffusion technology developped by sweetch energy is based on the most advanced nanotechnologies and specific membrane designat the end of the project a testing phase in partnership with an international industrial corporation will allow to reach a trl6 and secure the market readiness sweetch energy is targeting first the industrial sector and ambitions to become a global leader in the decarbonized electricity sector the project is supported by veolia and solvay
multifunctional multimaterial magnetic components and structures for electrification

electric machines and drives including various types of electric motors play an everincreasing role in the way of making europe the first climate neutral continent in the world in order to achieve a breakthrough in the field of energy efficient electric motors novel approaches are needed high performance sustainable materials and multimaterial manufacturing technologies suitable for complex geometrics and capabilities to design and simulate structures and components based on those the ambitious goal of multimag is to develop novel design tools high performance materials and multimaterial additive manufacturing mmam processes hence to manufacture ready assembled lightweight components for electric machines and leading to better performing machines improved energy efficiency and shorter lead times after use the components can be dismantled and the materials recycled effectively multimag takes the full advantage of multimaterial additive manufacturing stacked rotor and stator structures combining dissimilar magnetic and electric insulating materials are developed manufactured and validated to ensure mechanical thermal electrical and magnetic performance internal structures enabling more efficient cooling are studied and designed achieving ambitious objectives of multimag requires a holistic approach and innovations in all sectors namely in design materials manufacturing use and endoflife each of these vital areas are addressed by multimag activities we will develop a framework and specific toolbox for addressing complex design challenges which are multimaterial multifunctional and multiphysics evaluation and development of matching material properties enabling to join dissimilar materials using am processes is one of the key focuses of multimag multimag approach requires also mmam processes to be developed further as well as recycling of rees
euafrica research infrastructure alliance to foster infectious disease research knowledge sharing and innovation

the rafiki consortium will support capacity building for early drug discovery in africa with a focus on infectious diseases eg malaria tuberculosis subsaharan africa is disproportionately burdened by such diseases yet lacks a critical mass of appropriately skilled scientists and access to general infrastructure enabling technology platforms and expertise for drug discovery research rafiki will leverage existing collaborations within the consortium to build the knowledge and technical capacities of research institutions across africa rafiki will establish regional training hubs in south east and west africa to support local capacityskillset building for earlymidcareer researchers via bidirectional scientific training visits mentorships regional inperson workshops and online training courses to establish the requisite infrastructure for future drug discovery ri knowledge and procedures will be shared for compound library curation at partner institutions ie workflows open database creation library sharing capabilities and data management capacities will be bolstered using the collaborative drug discovery cdd vault to secure funding beyond the project lifetime the consortium will liaise with relevant industrial actors and potential publicprivate funders
avodes biotechnological menstrual product for candidiasis prevention

372 million women globally have a silent torturer recurrent vulvovaginal candidiasis vvc which affects 3 out of 4 women at some point in their lives despite therapeutic advances vvc remains a common problem worldwide affecting all strata of society and being the second largest gynaecological infection if it is left untreated many complications have been appointed as its consequence such as infertility subsequent preterm delivery suppression of the immune system pelvic inflammatory disease ectopic pregnancy pelvic abscess menstrual disorders and miscarriageavodes has developed an innovative medical device for menstruation a patented anatomically shaped moist sponge made of completely natural biodegradable materials biodegradable within 1 month it protects innate defence mechanisms of vaginal microflora during most vulnerable period menstruation studies have shown that fluctuating hormones and the resulting imbalance of vaginal flora cause an increased risk of a yeast infection every month unique avodes biotechnological solution preserves womens natural vaginal microbiota in the same time selectively inhibiting growth of pathogenic microorganisms it reduces risk of vulvovaginal candidiasis vvc by 85 thus effectively preventing the disease avodes is the only medical product designed to prevent infection rather than deal with the consequences avodes effectively disrupts the vicious cycle of microbiota disbalance infection antibioticfungicidal treatment microbiota disbalance and offers breakthrough solution which protects womens health and the environment women tech eu programme would support company in upgrading the business model business and marketing plan market validation and would help to find partners clinical manufacturing and commercial as well as to prepare funding strategy successful project implementation will provide much needed tailwind to our company to bring the product to the market
aquaponics from wastewater reclamation

aware sets out to increase capacity to produce fish for human consumption at km 0 in every european city with no impact on natural habitats no dependence from natural freshwater availability and high resiliency to climate changethis goal could be met by farming fish locally using reclaimed water europe lacks the regulatory and policy framework to allow such a value chain to take root due also to the absence of compelling scientific evidence of safety quality economic feasibility and social acceptabilitywith aware we want to remove the barriers preventing reclaimed water aquaculture from becoming a european reality we will demonstrate seamless integration of our solutions in an aquaponic recirculation system ras with iot monitoring and automation technologies to improve its operation and overall sustainability metrics we will create the first european case study for reclaimed water aquaponics in the town of fasano puglia italy where we will leverage the results of a preexisting h2020 project on advanced wastewater treatment with the case study we willdemonstrate technical solutions for efficient and sustainable aquaponics from reclaimed wastewaterincrease the circularity of wastewater as freshwater resource to be exploited where it is generatedcreate a new farmtofork value chain contributing to european economic growth and to urban km 0 farminglay the ground for a new regulatory and policy framework in support of european aquaculturethe project will go as far as conducting human intervention ie feeding tests on a panel of volunteers to obtain evidence of safety and quality of the produced food in parallel it will develop a sustainable business model and strategy for the for the future upscaling of the pilot solution including its application to other european communities and in international development projects our consortium includes a large network one extraeuropean partner and one international organisation
emergence in quantum materials from relativistic quantum criticality to nonfermi liquids and unconventional superconductivity

understanding and controlling novel states of matter is at the heart of condensed matter research in modern quantum materials we find a rich resource of extraordinary states which emerge from the complex interplay of quantum effects and manybody physics they pose the fundamental challenge of describing an interacting system with many constituents in the quantum realm and hold the key for future quantum technologya major common trait behind the complex phase diagrams of many correlated quantum materials evades a description with conventional manybody approaches a strange metal phase that exhibits non fermi liquid behaviour nearby quantum phase transitions and superconductivity quantemerge opens a new way to comprehend such non fermi liquids and their intertwined phases by establishing a connection to relativistic quantum criticality and moir materials relativistic quantum criticality arises at quantum phase transitions with emergent lorentz symmetry and can be viewed as a minimal model for non fermi liquid behaviour while moir materials constitute a new materials platform with unprecedented experimental control over such transitions their connection allows us to tune into the strongly correlated quantum regime from a controlled starting point in both experiment and theoryexploiting different tuning parameters such as interaction symmetry temperature and density we develop a comprehensive picture of emergent phases in a quantum critical regime with cuttingedge renormalisation group methods we characterise novel types of quantum phase transitions in this setup and determine the corresponding quantum critical behaviour we calculate thermodynamic and transport properties and study the competition of non fermi liquid and superconductivity our theoretical insights will provide an improved understanding of the remarkable quantumdominated phase structure that emerges in correlated quantum materials and pave the way for future materials design
how to evolve without centromeres meiotic recombination dynamics in holocentric plants

centromeres strongly affect genomic architecture and meiotic recombination distribution and also play a key role in constraining karyotype evolution the recombination landscape is also heavily influenced by chromosome number and structure ie karyotypes as at least one crossover per chromosome and rarely more than three occurs in most species making chromosome number the primary driver of recombination frequency in addition centromeres inhibit recombination and therefore crossovers tend to occur mostly at chromosome endshowever several unrelated eukaryotic lineages do not have centromeres or at least not conventional ones such is the case for plants with holocentric chromosomes where hundreds of small centromerelike units are evenly distributed across the length of the chromosome notably holocentricity has evolved repeatedly across the tree of life and at least four times during plant evolutionholocentric plant species offer a unique opportunity to study the plasticity of meiotic recombination control these species have lost typical centromeres making them ideal for investigating how the recombination landscape was reshaped after the transition to holocentricity moreover holocentricity unleashes changes in the karyotype offering the possibility to analyze the effects of chromosome breaks and fusions on recombination frequency and distributionthe holorecomb project aims are as followsianalyze how transitions to holocentricity affect meiotic recombination dynamics in different holocentric plant lineagesiiexplore the effect of chromosome breaks and fusions on crossover number and distributioniiiexamine whether the crossover regulation in holocentric plants acts in a similar manner as in monocentric onesunderstanding how holocentricity affects recombination dynamics will provide insights into important mechanistic aspects of meiosis with potential practical applications for crossover regulation in centromeric regions
innovative organic fruit breeding and uses

the organic fruit sector is highly dependent on inputs particularly in terms of plant protection climate change is increasing impacts and risks to organic fruit production large market demand is expanding for organic fruits but the current commercial cultivars cvs range previously selected in high input paradigm are for most of them not adapted to organic production innobreed proposes to mobilise innovative solutions iss social innovations new ideotypes new methods for screening robust cvs and genitors with larger genetic bases for fostering organic fruit breeding these iss will be targeted and developed on participative multiactor and multitrait based approaches and then applied for evaluating underutilized fruit tree genetic resources ftgr prebreeding and advanced material innobreeds scope encompasses many rosaceous species but also citrus and grape innobreed aims to improve the whole fruit chain through the implementation of an organic variety testing network of actors it deals with iidentification and definition of current lockin in organic fruit farming systems ofsii codesigning new ideotypes fitting with local ofsiiiidentification of performant is already available ivdevelopment of new climate change iss but also for fruit quality pests and diseases tolerance low input fitness and robustness and their application by ftgr curatorsv iss validation process and implementation by several publicprivate casestudies in different regions for evaluating their efficiency and vichecking sustainability and consistency with actual regulations before being disseminated for maximizing is impacts on the value chaininnobreed is deeply connected with running initiatives programmes and resources involved in ofs organic fruit participative and classical breeding fostering ftgr uses by fruitchain scientists and stakeholders particular attention will be paid to embed the relevant stakeholders at national and european levels
habenula molecular and functional organization in models of pathological emotional states

emotions guide humans and animals in the selection of behavioral strategies to optimize outcomes and promote wellbeing repeated or unexpected strong negative stimuli such as stressors impair the processing of emotions and lead to the development of mood disorders such as depression and anxiety understanding how individuals control their emotions and cope with stressful events has become a major clinical challenge for the development of new treatments this project aims to define the circuit mechanisms that control emotional regulation i will focus on a brain region key in emotional regulation namely the lateral habenula lhb over the past decades clinical and preclinical studies have identified the lhb as a major hub in the regulation of negative emotions and in the induction of mood disorders recent studies have highlighted that lateral hypothalamic lha excitatory inputs to the lhb drive negative emotions ie aversion and may play a role in depression however how the lhb integrates diverse types of inputs to promote negative emotions remains unknown the main hypothesis of the project is that the complex regulation of emotions is defined by a discrete organization of inputs to lhb that underlies maladaptive circuitspecific dysfunction in models of stress i will investigate here the molecular and functional properties of the lhb neurons based on their discrete inputs from the lha i will use a multidisciplinary approach combining cuttingedge spatial transcriptomics neuronal tracing and optogenetics to define for the first time the role of the molecularlydefined discrete lhalhb pathways in normal and diseaserelated behaviours this project will provide key insights about the regulation of mood by the lateral habenula and how the inputs from the lateral hypothalamus are key in the pathophysiology of depression and anxiety disorders
healthy adaptation to pregnancy postpartum and parenthood

annually around 4 million european couples face lifechanging transitions as they move from pregnancy to postpartum and early parenthood these transitions require adaptation to changes and challenges for women and their partners obesity and mental health problems are the two most common and interconnected complications with significant implications for overall health and wellbeing of future families and high costs for society the hap3 network builds capacity for tackling these challenges to meet the needs of women and their families and assist care providers in their pivotal roles integrative familyinclusive stateoftheart monitoring and coaching modules are neededresearch objectives of hap3 are 1 to examine risk and protective factors and mechanisms of obesity and mental health problems 2 to cocreate an online hap3 intervention consisting of a family app and dashboard for care providers 3 to test the feasibility of the family app and dashboard 4 to identify implementation factors and to develop implementation strategies for the implementation of the hap3 interventionhap3 deliverables are a list of critical health indicators related to prevention of obesity a validated prediction model for early childhood obesity an operational cocreated hap3 intervention infographics for care providers including strategies for the reach of vulnerable groups a report on policylevel barriers and facilitators for the implementation of the hap3 intervention a toolbox for the future implementation of the hap3 intervention the hap3 training objective is to educate future perinatal care innovators in knowledge research expertise and transferable skills needed to lead improvements in realworld care settings