Dragon09/odtu_chatbot huggingface dataset:
extraction modelling and analysis of the brain vessel tree

the brain vessel tree is essential to brain function however we still have limited knowledge about this structure compared to other organs that have been extensively studied while atlases have been helpful in advancing our understanding of the brain in neurosciences the same progress has not been seen for the brain vessel tree its extraction modelling and analysis still pose several methodological challenges making it impossible to accurately robustly reliably and reproducibly quantify and compare it across individuals within large populations as a result brain vascular atlases that provide a comprehensive representation of the brain vessel tree are scarce and the existing ones face important limitations this is a critical bottleneck towards understanding the role played by the neurovasculature in pathology onset ageing and wellbeingcaravel is an ambitious project at the intersection of biomedical imaging neuroscience computer vision statistics and medicine aiming to transform neurovascular image analysis it will devise a radical new approach to build and provide the first population atlas of brain vascular ageing encompassing multiple scales and it will formulate a robust and reliable methodological framework to accurately extract model and analyse the brain vessel tree in a reproducible way our efforts will enable the study of the brains vascular system at a scale that is currently unattainablethe atlas and its methodological framework will be freely available to the scientific community this will help clinicians and researchers to test and validate new hypotheses discover knowledge about the brain vessel tree and its interaction with the brain and contribute to numerous clinical applications hence caravel shall have a tremendous impact on society and the economy
establishing collaborations with danish dairy farmers to support epiherd platform development and generate novel epigenomics data from cattle to address animal health and productivity

antler bio is a deep tech company that supports animal health efficiency and performance through epigenomics we have developed a novel technology and concept which data is powerful enough to change livestock and agricultural industries for the better to meet the global goals for a more sustainable future we are tapping the currently underexplored data of epigenomics analysing which crucial genes linked to health and production in livestock are active expressed and which are silent furthermore the environmental factors such as habitat animal husbandry and feed affect gene expression understanding this data allows precisionadjustments to increase wellbeing and production in a natural way to deliver this data to dairy farmers we are developing epiherd an aiplatform currently at trl5 that aims to help farmers analyse herd performance against its actual potential improve animal management and husbandry in a targeted way strategically select individuals for breeding and production and detect developing health disorders before symptoms arise with substantial proof in equine and having successfully transferred the technology to bovine we now collaborate closely with key organisations and selected farms in finland to widen our epigenomic database and develop the platform based on farmer feedback being an earlystage deep tech company struggling to find adequate funding the cost of acquiring the gene expression data is currently our greatest challenge hindering growth and expansion if we were to be supported by the women techeu programme we will execute the plan outlined in this proposal to collaborate closely with 6 danish dairy farms enabling us to diversify our epigenomic database and capture crucial feedback that will influence platform and service development the programme would also impact antler bio through offering support that will help me develop and grow as a ceo which will reflect on the performance and success of the company
dissecting the biophysical mechanisms of deep brain stimulation using voltage fluorescence microscopy

deep brain stimulation dbs is a promising neuromodulation technique for the treatment of neurological and psychiatric diseases dbs electrically stimulates brain tissue via implanted electrodes however the biophysical and therapeutic mechanisms underlying dbs remain largely unknown while longstanding theories suggest that dbs suppresses neurons subsequent studies have shown that dbs activates neurons via direct axonal excitation modulating membrane dynamics information transfer and network synchronization unfortunately this conundrum has been difficult to resolve experimentally because of 1 the electrical interference occurring in electrodebased recordings and 2 the challenge of measuring cellularlevel membrane voltage dynamics in the awake brain in this proposal i will overcome for the first time both key challenges by using a novel invivo voltage fluorescence optical technique that permits the direct recording of the membrane voltage from identified neurons in awake animals free of electrical interference i will combine voltage fluorescence microscopy and electrical stimulation in a mouse model of epilepsy to optically dissect the cellular mechanisms underlying therapeutic dbs for reducing seizures in the limbic system this innovative and comprehensive approach will provide novel insights into the cellular and circuit processes occurring during dbs in the awake epileptic brain this research program will provide an unprecedented opportunity to build a mechanistic framework of dbs and stimulation parameter selection with the ultimate goal of identifying more effective and targeted dbs protocols for human patients
unraveling the etiology of congenital heart defects the role of maternal genetics and cardiovascular disease as a risk factor

one in a hundred infants is born with a congenital heart defect chd both genetic and environmental risk factors such as maternal diabetes and obesity are known to cause chd however little is known about the disease mechanisms behind these risks chd can occur as an element of a syndrome in conjunction with other anomalies or as an isolated defect i propose that there is an etiologically distinct environmental chd subgroup where in addition to the childs genes maternal genetics and gene expression play a major role in disease development moreover i propose that in these cases the genetic risk profile predisposes the woman for both having offspring with chd and having early onset atherosclerotic disease my objective is to study how maternal genetics and maternal cardiovascular morbidity as an environmental risk contribute to the risk for having offspring with chd in addition the multifactorial aetiology in terms of the presence of both risk factors will be studied using a unique dataset available only in finland three different substudies will be conducted 1 finnish national registers gathering health related information of all finns from birth to death will be used to determine the presence of atherosclerosis and related traits such as hypertension and coronary artery disease in mothers who have offspring with chd compared to those without tot n 1 million 2 maternal genetic risk loci for having chd in the offspring will be sought in the finngen study tot n 05 million 3 maternal 1st trimester serum samples from pregnancies with and without chd will be analysed to identify chd associated biomarkers tot n 3200the study results will provide important information on how the combination of maternal genetic and environmental risk factors contribute to cardiac developmental defects during early pregnancy and offer new insights for future research on the cellular and molecular mechanisms of cardiac development
innovative energy storage systems onboard vessels

aeneas aims to contribute towards climateneutral and environmental friendly water transport through three new next generation clean energy storage solutions eventual impact is an increase of the global competitiveness of the eu waterborne transport sector by european technology leadership for energy storage solutions for diverse waterborne applications it will focus on increased and early deployment of climate neutral energy storage solutions and significant electrification of shipping aeneas will provide solutions to improve overall energy efficiency and drastically lower energy consumption of waterborne transport vessels founded upon innovative electric energy storage which is safe and cost competitiveness compared to traditional batteries to achieve this aeneas will develop three innovative electric energy storage solutions ess for waterborne transport which are advanced beyond the traditional battery systems solidstate batteries ssb for constant load waterborne transport applicationssupercapacitors sc for waterborne transport applications for shaving of power peak demands and peaks during loadinghybrid system which combines ssb and sc for waterborne transport applications requiring high energy and power density energy storage solutionsthe solutions enable partial or full electric shipping taking into account conditions specific ships might encounter including adverse conditions outside sheltered waters or going upstream on rivers aeneas will evaluate them for a range of applications and end uses in shortsea shipping and inland waterways for each of these three esss one usecase will be demonstrated at trl 5 at the same time aeneas will define the pathway for the three esss for application in different ship types achieving a comprehensive understanding of the esss and their applicability for diverse waterborne transport finally aeneas will define a roadmap for full scale onboard demonstrators of two esss by 2027
antagonizing gnrh signaling as a holistic therapeutic strategy for polycystic ovary syndrome

pcos is the most common endocrine disorder affecting up to 18 of women worldwide the syndrome imposes a heavy health burden covering infertility obesity type 2 diabetes and metabolic syndrome the development of treatment options is an urgent need since there is currently neither a cure nor mechanismbased treatments leaving patient management suboptimal and focused solely on symptomatic treatment one key neuroendocrine aberration in most women with pcos is increased luteinizing hormone lh pulse frequency this suggests an increase in activity of gonadotropinreleasing hormone gnrh neurons in the hypothalamus the lh hyperpulsatility contributes to increased ovarian thecal androgen secretion and failure of ovulation constituting a pivotal pathogenic role in the syndrome these evidences suggest that alterations of gnrh neuronal activitysecretion could be the basis for neuroendocrine anomalies that accompany the reproductive disturbances in the syndrome in grasp we will test the hypothesis that low administration doses of a gnrh antagonist aimed at tempering lh secretionpulsatility can ameliorate both reproductive and metabolic pcos traits in animal models of pcos and in women with pcos the specific objectives of grasp are to i doserange gnrh antagonism to rectify lh pulse amplitude and frequency in pcoslike mice ii to perform a longterm treatment with the selected doses of gnrh antagonist to assess its potential beneficial outcomes in correcting reproductive and metabolic alterations of this preclinical model iii to perform a pilot doseeffect clinical investigation testing the ability of subtherapeutic doses of gnrh antagonist to rectify the altered hormonal dynamics in women with pcos the overall goal of grasp is to provide a proofofconcept for future longduration randomized controlled trials of this approach to appraise its clinical benefits in women with pcos and to move forward towards therapeutic innovation
smart cardiac magnetic resonance delivering oneclick and comprehensive assessment of cardiovascular diseases

cardiovascular disease cvd causes at least 18 million european deaths annually exceeding fatalities from cancer chronic respiratory disease and diabetes consequently the fight against cvd has become the main priority of the world health organizationin the pursuit of understanding and treating cvd cardiac magnetic resonance imaging cmr has remained the only modality capable of providing a comprehensive assessment of the hearts function and structure without harmful radiation unfortunately current cmr systems remain too slow too complex require highly trained specialists and as such have presented a barrier to a wider adoption of cmrthe aim of my erc project is to unleash the full potential of cmr to transform patient trajectories by introducing a fast oneclick fully automated and comprehensive imaging pipeline applicable to diagnosis prognosis and therapy selection in cardiologythis aim will be achieved by i creating a novel imaging technology that collects cmr data in a single continuous freebreathing scan taking into account postprocessing requirements at the very origin of cmr sequence design ii exploiting the unique contrasts generated by this technology to automatically extract quantitative markers on cardiac anatomy function and tissue characteristics and iii translating this transformative technology from a preclinical to a clinical settingthis will be the firstever integrated cardiac imaging pipeline in which cmr images are acquired in a single click jointly represented in a single volume and automatically analysed this will unlock obstacles for broader acceptance of cmr and unleash the full potential of cmr to maximize its impact on patient trajectories the results of this project will pave the way towards robust imagebased strategies for personalized patient care diagnosis risk stratification therapy selection monitoring and imageguided interventions
implementing oral and long acting preexposure prophylaxis in mobile men in subsaharan africa mobile men

reducing hiv is key 2030 sdg target in africa hiv prevention research has focused on young women yet heterosexual men vulnerable due to their mobility remain who priority longacting injectable cabotegravir cabla and ondemand oral preexposure prophylaxis prep have not been evaluated in such men who are not inline to receive either building on our eu studies men want ondemand prep and cabla referred to as new prep options this project using reaim framework reach effectiveness adoption implementation and maintenance uses rapid assessment followed by implementation trial objectives1 catalystsbarriers across local and regional contexts that could influence uptake of new prep options by mobile menaqualitative assessment mobility patterns of men knowledge perceptions of prep effectivenessbpolicy analysis at local and national level2 assess implementation effectiveness of new prep options by comparison of retention in care effective use and expressed choiceopenlabel study of 400 men from mobile groups in south africa and uganda randomised to oral tdfftc or cabla over 9 months then access to both to 18months3 preferences of mobile men amongst new prep options aadoption of new prep options bbarriers in non prep acceptorscpatterns of prep use dparticipant staff community reflections 4 reach and implementation of prep for mobile men amongst service providers to inform scaleupareach of prep bfeasibility of delivering prep in different settings cfidelity of prep delivery in practice dservicelevel needs and adaptations to implement prep objectives 3 and 4 use mixed methods in users and service providersobjective 5 affordability cost and cost effectiveness of new prep options using hiv synthesis modelthis first multicountry study of ondemand prep and cabla in men in africa provides evidence for guidelines change inform scalability and provide operational tools for prep implementation
broadspectrum antiviral sirnas influenza strains targeted by anticipation

fighting emerging viruses has been a major challenge in the development of novel therapeutics with the current global changes and massive modification of the biosphere the issue will surely increase in the future to overcome this challenge we will demonstrate on influenza that we are capable to produce active antiviral against a strain that is not yet existing the barista project will allow to develop a novel therapeutic approach allowing to preserve therapeutic activities over a wide range of influenza strains and we will demonstrate its efficacy on the influenza strain of the next outreach this achievement will be obtained by guiding the design of chemically optimized sirna by detailed nmr structural analysis those molecules will be tested both in vitro and ex vivo and their broadspectrum activity will be demonstrated on past present and future influenza strains this project will therefore open the way to therapies that can be designed and optimized even before the appearance of a novel strain providing an invaluable help in fighting emerging viruses
development of a boryl radicalmediated hatom transfer umpolung blueprint to make nucleophilic radicals behave as electrophilic species

aliphatic molecules are integral to every aspect of chemistry and radical chemistry has strong impact in their preparation however radical reactions are heavily influenced by the polarity of these species which ultimately controls their reactivty profilemost notably standard alkyl radicals are nucleophilic and therefore do not react with electron rich aromatics and olefins electrophilic radicals display strong reactivity with these species but they are of limited synthetic valuethis project seeks to address this challenge by developing an innovative approach for radical umpolung in particular we will demonstrate the integration of photoredox catalysis and boryl radicalmediated hatom transfer catalysis as a unique blueprint for the activation of alphaalphadiborylated alkalnes this will generate alphaalphadiborylated radicals that owing to their strong electrophilic character will i react with electron rich aromatics and olefins and then ii enable diverge functionalization in this way we will overcome the fundamental issue that nucleophilic alkyl radicals do not react with electron rich olefinsaromatics this reactivity will streamline the preparation of many highvalue but difficult to make aliphatic products will be used in latestage functionalizations and will substantially expand the fields of photoredox catalysis and boryl radical chemistrythis research capitalizes on recent developments of the leonori group that has experience in the design of methodologies based on both hatom transfer and boryl radical reactivity the completion of such an innovative and ambitious project at rwth aachen university will be facilitated by generating transferring sharing and disseminating knowledge and will enhance my future career following the training plan envisioned
deciphering cellular networks for membrane protein quality control decisions

any cell and each of its organelles needs to interact with its environment membrane proteins which span the plasma membrane and the multiple endomembranes of a eukaryotic cell mediate these interactions they allow cells to move thrive and defend and multicellular organisms to exist humans dedicate almost one third of their genes to membrane proteins failures in membrane protein biogenesis or function cause numerous human diseases from cancer to neurological disordersby far most eukaryotic membrane proteins are produced at one organelle the endoplasmic reticulum er where a dedicated protein folding and quality control machinery supports and controls protein structure formation in contrast to our comprehensive understanding for secreted proteins our understanding how cells support and control the biogenesis of membrane proteins is still limited to further advance our understanding in this key area in molecular cell biology is the major aim of this proposal using recent biochemical and cell biological techniques combined with newly developed tools we will address the following major questionshow do cellular quality control factors determine the folding state of a membrane proteinwhich molecular signatures underlie the decision to chaperone or to degrade a membrane proteinhow do chaperones collaborate in membrane protein biogenesiswhich further membrane protein chaperones and quality control factors exist in the mammalian eranswers to these questions will be major steps forward in our understanding of the inner workings of cells but also of the mechanisms underlying membrane proteinassociated diseases three objectives will serve this goalobjective 1 define signatures of intramembrane quality control decisionsobjective 2 dissect chaperone synergies in membrane protein biogenesisobjective 3 identify novel membrane protein chaperones by functionally validated interactome analyses
european virtual institute for research software excellence

the everse project aims to create a framework for research software and code excellence collaboratively designed and championed by the research communities across five eosc science clusters and national research software expertise centres in pursuit of building a european network of research software quality and setting the foundations of a future virtual institute for research software excellencethis framework for research software excellence will incorporate aspects involving community curation quality assessment and best practices for research software this collective knowledge will be captured in the research software quality toolkit rsqkit a knowledge base to gather and curate expertise that will contribute to highquality software and code across different disciplinesby embedding the rsqkit and services into the eosc science clusters everse will demonstrate improvements in the quality of research software and maximise its reuse leading to standardised software development practices and sustainable research software furthermore we will drive recognition of software and support career progress for developers from researchers who code to rses raising their capacity to guarantee software qualitythe european network for research software quality aims to crossfertilise different research domains act as a lobbying organisation and raise awareness of software as a key enabler in research with the overall ambition to accelerate research and innovation through improving the quality of research software and codeeverse ultimate ambition is to contribute towards a cultural change where research software is recognized as a firstclass citizen of the scientific process and the people that contribute to it are credited for their efforts