Dragon09/odtu_chatbot huggingface dataset:
wireless networks at optical speed with deterministic performance

future networks will support several applications that require extending fiberoptic quality of experience to wireless links this means connectivity at extremely high data rates with deterministic performance guaranteed requirements in terms of reliability and time response virtual avatar presence traffic control autonomous driving remote health monitoring cyber physical systems for intelligent transportation industrial automation are only a few examples of anticipated use cases owing to the large amount of available bandwidth the european telecommunications standards institute has identified terahertz thz as a key technology for future wireless networks terawireless is the first eu trainingthroughresearch industrial doctoral network of doctoral candidates and senior supervisors fully committed to lay the theoretical algorithmic and architectural foundations for enabling thz systems at optical speed with deterministic performance terawireless will 1 put forth the innovative ultramimo multipleinput multipleoutput technology for increasing the data rate and link reliability through spatial multiplexing and superdirective beamforming and will pioneer the development of electromagnetic and communication models for evaluating its performance in lowscattering thz channels where multipath propagation cannot be exploited by integrating sensing localization communication capabilities 2 leverage the emerging concept of semantic and goaloriented communications by folding message semantics and goals of communication within communication layers 3 develop innovative physicsbased ml solutions for energyefficient robust reliable and explainablebydesign implementations 4 make available to the research community the eus and worlds first openaccess and opensource simulation environment integrating ray tracing linklevel and systemlevel features for evaluating and optimizing thz largescale deterministic networks at optical speed
electrified conversion of plastic waste into olefins downstream integration

the overall objective of electro is to demonstrate a revolutionary technology concept that links the waste and petrochemical industry and provides them with a sustainable low ghg footprint and scalable circular solution for olefin and polyolefin production the priority for electro is the plastic waste streams that are currently not recycled but rather either incinerated or dumped to landfill examples are multilayer plastics mixed peppps and waste ps an innovative modular extruder for optimal pretreatment of plastic waste will be combined with an electrically heated reactor for the catalytic pyrolysis of plastic waste at trl 7 the main product plastic waste pyrolysis oil will be used as a feed for steam crackers steam cracking will be electrified in the rotodynamic reactor rdr a second novel reactor technology to be demonstrated at trl 7 in electro in the rdr heat transfer is accelerated by an order of magnitude compared to heat transfer rates achieved in the fired heaters used in conventional crackers and so the rdr has a substantially higher selectivity towards light olefins and improved process efficiency the light olefins will be further processed into pe and pp demonstrating the technical feasibility of chemical recycling and the use of plastic waste as a circular carbon feed this scalable concept will enable strong industrial symbiosis with the initial lca showing an 90 ghg reduction compared to todays best available technology bat given the amount of plastic waste that can be converted and the market demand for the compounds produced the impact of electro will be profound to further extend the impact of electro the global replicability and economic viability of the proposed concept will be demonstrated using waste streams from the republic of korea and indonesia and a thorough programme will be implemented to train the next generation of waste management engineers and workers
evolution of biomolecular condensates

cells organize billions of protein molecules into membranebound and membraneless compartments called biomolecular condensates previous research on condensates focused on identifying their components material properties and function in homeostasis and disease in contrast to our relatively precise understanding of membranebound compartments we lack a comprehensive picture of the mechanisms that target proteins into condensates and how condensates emerged during evolution i hypothesize that localization into condensate is encoded in protein sequences and that functional condensates are under selection pressure and therefore conserved i propose a comprehensive research program including both theoretical and experimental approaches to reveal how and when protein condensates emerged during evolutioni propose to1 map proteomes of condensates across the tree of life2 reconstruct the history of condensates3 follow trajectories of condensate evolutionspecifically i will1 investigate what conserved sequence features drive localization to condensates by developing computational tools to predict the proteome of specific condensates across the tree of life and by testing partitioning of proteins into condensates experimentally2 reconstruct the evolutionary history of the protein components of conserved condensates and thereby trace their evolutionary origin analogous to protein families we will define condensate families based on shared properties of their proteins and function by developing similarity metrics we will reconstruct the phylogeny of condensate families and compare to organism and organelle evolution3 perform directed evolution of ancestral noncondensateforming proteins towards condensate partitioning and follow their mutational trajectories building on our already developed tools and the new algorithms proposed here combined with experiments we will be able to map the molecular history of condensates on the tree of life
intelligent device and computational software to control mechanical stress and deformation for biological testing

in nature all biological material from the cell to the tissue level is subjected to continuous mechanical stress and strain these mechanical cues play an essential role on several biological processes and can determine the fate of a healing or a cancerous process among many others therefore research activities focusing on studying the deterministic nature of these processes need a robust test platform that allows for reproducing these mechanicallyvarying environments such a system would significantly contribute to improving invitro testing of therapies and drug discovery incorporating the essential influence of mechanics in pharmaceutical and biotechnological companies however the current approaches are restricted to basic science methods with important limitations this lack of a suitable system hinders the translation of basic science in mechanobiology to its application in the industrialtechnological field isbiomech proposes a novel intelligent system to control the mechanical environment of cellulartissue materials to be commercially exploited as laboratory equipment for mechanobiology research and pathological treatment testing the novel device and associated software will provide the first commercially available system to allow for robust and reproducible invitro testing of mechanicallyinfluenced biological processes more concretely the system will use magnetoresponsive substrates allowing for noninvasive multidimensional and realtime control of complex deformation modes on cellulartissue materials this technology will be implemented and validated by demonstration activities at stakeholders labs to address timely mechanobiological studies in epithelial wound healing neurological disorders and cardiac pathology the proposed system has the potential to open the experimental path to improve current treatments in eg cancer pathologies pathological skin scarring or fibrotic heart remodelling during myocardial infarction
constructing amlo political persona visual media and populism in mexico

the global resurgence of populism continues to have devastating legislative effects particularly for human rights and media independence while contemporary scholarly investigations into this political phenomenon tend to focus on rightwing populist figures it is essential to broaden understanding beyond this current anxiety to combat the rise of antidemocratic movements a more nuanced understanding of populism derived from this study will decentralise the eurocentric conflation of populism and the political right that exists at present the proposed project will respond to the rich scholarship emerging from latin american scholars on leftwing populism to enrich global debates and critical reflection on the question of how to define populism and challenge its pervasive narratives the project will examine the visual representation of leftwing mexican populist president andrs manuel lpez obrador 20182024 from his first presidential campaign in 2006 to the end of his first year in office in december 2019 scrutinising this case study in dialogue with other latin and north american populists the proposed research will facilitate closer engagement with presentday populism public persona and the mediatising of politics with ten years of experience in researching the representation of mexicos political system predominantly through film and visual media and with a focus on its figureheads i am uniquely qualified to pursue this line of investigation to deliver this project i will be drawing on five documentary texts a selection of televised morning press conferences maaneras and referencing social media in order to analyse the creation of a political persona in the context of the mexican sociohistoric landscape my deep interest and expertise in contemporary mexican politics media and art my commitment to decolonizing research and scholarship and my extensive portfolio of work on the intersection of these subjects will form an exceptio
smart maritime and underwater guardian

the primary goal of smaug is to improve the underwater detection of threats in ports and their entrance routes by means of a integrated system capable of providing data concerning threat analysis between 3 main elements ports security infrastructure advanced underwater detection systems and surveillance vessels underwater detection and location will be performed by four primary methods i acoustic detection where a series of hydrophones will listen for sounds emitted by small underwater vehicles and will be processed by artificial intelligence methods ii rapid sonar hull scan used to scan ships hulls and perform harbour floor scanning iii high resolution sonar inspection to inspect objects in water with poor visibility and iv collective autonomous location where a swarm of autonomous underwater vehicles will act cooperatively this will provide information to artificial intelligence modules which will improve the way detecting illicit and dangerous goods andor of threats hidden below the water surface is currently done taking into account sources such as unmanned surface vehicle systems usv underswater remote operation vehicle rov uav aerial autonomous vehicle and port current information sources the combination of these tools will allow smaug to prompt solutions capable of detecting possible threats to infrastructure or vessels as well as identify vessels with concealed goods
hybrid virtualized testing for certification of egnss in railway train positioning

vice4rail aims to accelerate the adoption of egnss for deploying efficient resilient and competitive ertms solutions focus is on the development of a certification and standardization process for the use of egnss closing the gaps for rail safety critical applications and converging towards a paneuropean egnssbased solution for ertms and its global rollout the starting point is the use of egnos v2 and the balise virtualisation as indicated by the european parliament directive on july 2021 opening the way for further applications based on the absolute train positioning and egnos v3 two major developments will be undertaken identification of suitable certification procedures compliant with the cenelec norms and realization of a hybrid virtualized testing certification environment based on the zeroonsite testing paradigm with the construction of a dedicated testing facility on a rfis railway lines where gnssbased multisensor positioning solutions can be evaluated and certified in operational scenarios this unique testing environment will be connected with the ertms accredited laboratory of cedex to assess the endtoend performance of the ertms chain with gnssbased positioning devices in operational scenarios behaviour of the system under gnss signals that include faults very rare and difficult to experience field but with a potential high impact on safety can be evaluated avoiding extensive and not exhaustive field tests vice4rail will exploit the synergies with the pilot line novara rho funded by rfi to integrate gnss positioning into the ertms and the shift2rail gate4rail project that introduced the zeroonfield virtual testing for gnss furthermore thanks to sncf cedex rfi and sogei a liaison will be established with the europes rail r2dato project to complement their ongoing activities and sharing results and assets and with the rtcm sc 134 special committee that is completing the standardization process for gnss receivers for rail
viral hijacking of the hippo pathway hcmvencoded viral gpcrs us28 and ul78 differentially modulate the hippo pathway in cancer

the human cytomegalovirus hcmv is a herpesvirus that infects large parts of the population with a prevalence of 80100 in europe in healthy individuals hcmv infection usually induces little to no symptoms however recent findings indicate that hcmv might contribute to a variety of diseases including cancer and heart disease two of the leading causes of death in europe the aim of this project is to uncover how and why hcmv changes the progression of cancer to achieve this we will investigate two hcmvencoded viral g proteincoupled receptors vgpcrs us28 and ul78 like other viral proteins these vgpcrs hijack the signaling network of the host cell specifically us28 and ul78 modulate the hippo pathway which controls cell proliferation and organ growth as dysregulation of the hippo pathway has been linked to cancer modulation of this pathway by these vgpcrs may be a crucial determinant of hcmv on cancer progression our preliminary findings show that us28 and ul78 activate distinct mechanisms to hijack the hippo pathway us28 couples to g proteins of the gqg12 family which are known to lead to hippo modulation conversely ul78 does not signal to gqg12 and seems to hijack the hippo pathway via a different undescribed mechanism thus we will use a combination of biochemical readouts to investigate the signaling of us28 and ul78expressing cells to identify the distinct signaling mechanisms by which each vgpcr hijacks the hippo pathway we will also investigate the outcomes of this hippo pathway modulation in a viral cancer setting by infecting a glioblastoma cell line with hcmv strains that either encode or lack us28 or ul78 our findings will contribute to a fundamental understanding of how hcmv can influence progression of cancer moreover these studies might potentially identify a new mechanism linking gpcrs to cell proliferation in the long term this project may lay the groundwork for the discovery of new cancer treatments
developing technologies to engineer plant genomes at the megabase scale

genomics research combined with revolutionary genome editing tools has created new opportunities to explore fundamental aspects of biology and develop novel biotechnologies for medicine agriculture and industry the omega project is designed to build on these developments by enabling megabasescale engineering of plant genomes experimentallydetermined lists of essential genes have been crucial for such largescale projects in other species but are currently unavailable in plants therefore the omega project needs to determine which plant genes are essential for growth and development however the standard technologies used to identify essential genes are limited by genetic interactions eg redundancy synthetic lethality my group is developing multiplex crispr screens in plants to specifically overcome these limitations the omega project will use this capability to identify genomewide essential genes and genetic interactions in physcomitrium patens this will be the first systematic genetic interaction screen in plants and will likely identify interactions conserved across the green lineage the omega project will also develop technologies to move edit and delete dna at the megabase scale as proofofconcept i aim to reduce 10 of the p patens genome and remove all nonessential dna from one chromosome the scramble system will be adapted for p patens and used as an alternative approach to minimize chromosomes and also perform in planta directed evolution lastly we will use a dna assembly method developed in my lab to build biosynthetic pathways in vivo using modular dna assembly methods these tools will create opportunities to explore fundamental aspects of genomics chromosomal biology and synthetic biology the objectives of project omega are necessarily ambitious as these technologies will allow us to perform controlled megabasescale engineering projects in plant genomes not possible with the current generation of genome editing tools
carnivores in human settlements a new and different way to address the middle palaeolithic record

anthropogenic sites often emerge from overlapping actions andor occupations that include disruptive processes consequently the palimpsests that arise can have a disorderly appearance which may complicate the interpretation of such sites the problem is worsened when some agents such as carnivore scavengers act on the archaeological record causing the remains to disappear and leaving no obvious signs of their passage such occurrences have important consequences for archaeological studies especially when trying to apply ethnographicallyderived postulates created in highresolution temporal contexts however new interpretations that are more complete can overcome this problem if the behaviour of scavengers is modelled using controlled experimental programs with wild carnivores neotaphonomy scavengers consists of monitoring experimental reproductions of hearthrelated assemblages like those described in archaeological contexts exposed to different species of wild carnivores hyenas lions bears wolves and other smaller carnivores the results will then be subsequently tested on different middle palaeolithic assemblages using artificial intelligence through computer techniques based on convolutional neural networks however the main aim is to generate crosssectional data that can be applied to all periods and geographic areas overcoming the limits of traditional archaeological methods to make accurate inferences about past human behaviour the results of this project will contribute to the development of a new paradigm changing some basic ideas about prehistory there is a risk of generating a huge and unmanageable quantity of variables from neotaphonomy however accumulated information and experience will provide valuable data and information for other areas of knowledge such as those related to naturalistic studies animal behaviour and management of natural resourcesparks
automated canceronachip organspecific metastatic spread

despite the improvements in cancer treatments diagnostic tools and preventionearly detection strategies cancer is still a major public health burden as one of the 6 leading causes of death worldwide in 2020 90 of the 10 million deaths registered out of 193 million new cancer diagnoses were associated not with primary tumors but with the secondary ones generated by the metastatic processthe complex timedependent chain of events and cascades of biophysical and biochemical factors regulating tumor metastasis cannot be replicated using conventional in vitro cell models such as transwell invasion and scratchwound healing assays nor in vivo animal models the scientific and medical communities are striving to better understand the steps of metastatic spreading to devise strategies to stop its occurrence especially in pediatric oncology as in the case of neuroblastoma the most common and difficult to treat among tumors of preschool age 15 of pediatric oncology deathsto solve these limitations we propose arachnid a unique multiplexed automated and increasedthroughput multiorgan on achip platform conceived around the complex process of cancer metastatic spread the projects potential for breakthrough innovation resides in its unique capabilities promising to accelerate research reduce costs and contribute to the development of more effective cancer treatmentsthe arachnid project aims to explore and prove the technicalcommercial potential of our proprietary tumormetastasisonachip tmoc platform starting from pediatric tumors and extending the application to adult cancers involving biogenera biotechnological sme operating the pharma nb domain as a testbed and early adopter
crossdisciplinary network for research excellence in regenerative economy innovation ecosystems

the project aims to raise excellence in science and value creation through deeper and geographically inclusive cooperation in alliance of higher education and research institutions in 5 widening and 4 scienceleading european countries to support the shift towards a regenerative economy paradigm global competitiveness and visibility of the he institutions in widening countries are to be improved by creating critical knowledge and research mass through cooperation with leading european research institutions in the area of the regenerative economy directly aimed towards the twin green and digital transitions this is to be achieved through clearly defined and measurable subgoalsto achieve a more balanced circulation of talents leading to a diverse and inclusive research community and innovative research outcomes by organising exchanges short visits and conferences participationsto reinforce the role of he institutions in innovative ecosystems by bringing additional expertise and resources by european leading researchintensive institutions to support the development of innovative ideasto mainstream practices and tools for open knowledge and data sharingto make progress toward reforming the research assessment system including career assessmentto improve links between science and business by providing access to networks resources and expertise to support the development of business partnerships and collaborationsto promote gender equality diversity and inclusivenessto accelerate societys green and digital transition to support era policy agenda action 11to encourage collaboration with thirdcountry entities to support era policy agenda action 9the project contributes to the aims of empowering universities as actors of change in ri by promoting crosssectoral collaboration between universities and other actors in the ri ecosystem improving their knowledge valorisation capabilities and contributing to raising excellence in science