Dragon09/odtu_chatbot huggingface dataset:
dissecting the functional role of mucosal iga clonal and glycoprofiles for effective humoral mucosal protection

numerous mucosal vaccines and igabased monoclonal antibodies aimed at a robust immunity within the respiratory tract are in development to combat viral endemics and pandemics however investigations into humoral immunity have predominantly focused on circulating antibodies particularly those of the igg isotype this has left a significant void in our understanding of the role of mucosal iga proteoforms in conveying effective immune protection this crucial knowledge gap deprives vaccine and antibody development of crucial determinants or immune characteristics to replicatein response to this we will conduct indepth investigations of mucosal iga including in vitro and in vivo functional evaluations we will capitalize on recent advances in liquid chromatography and mass spectrometrybased approaches for the detailed characterization of mucosal iga clonal repertoires and glycosylation profiles a field that has remained completely unexplored until now bcell receptor sequencing monoclonal iga glycoengineering and in vitro functional assays we will take advantage of our unparalleled biobank of human nasal secretion samples with clear documentations of infection outcomes on an individual level what sets our approach apart is thereby the unprecedented molecularlevel characterization of iga directly linked to their in vitro functionality and predefined clinical outcomes which clearly surpasses current stateoftheartby harnessing our indepth characterization of mucosal iga coupled to functional traits we will generate iga templates with enhanced binding and neutralization capabilities as well as functionally advantageous fc effector potencies our overarching aim is to provide molecularlevel blueprints for protective monoclonal igaantibodies enabling the finetuning of vaccine formulations and monoclonal antibody generation with a higher degree of accuracy ultimately enhancing their efficacy and safety
architectural technology transfer on the silk road iranian doubleshell domes and the west 14th to 20th century

domes is an exploration of the shared architectural legacy of europe and the middle east specifically my project details the transmission of architectural knowledge across the silk road from persia to medieval italy during the fourteenth century utilizing an innovative research methodology domes aims to overcome traditional classification of architectural history based on the linear evolution and comparison of styles and forms to promote a more comprehensive account of the history of construction nourished by the material understanding of sitespecific traditions utilizing structural building techniques as the basis for the project domes focuses on the transmission of two types of architectural knowledge technical knowledge and preservationist knowledge this project proposes that the technological knowledge of building doubleshell brick domes was originally transferred from iran to italy furthermore domes investigates the historical exchange of italian architectural restorers and iranian preservationists through the study of the restorations of the same doubleshell brick dome monuments during the 196070s through the combination of the study of unpublished archival documents in tehran and the onsite analysis of the restorations carried out on monuments domes will provide an innovative example of medieval global architectural history and will narrate the transfer of preservation knowledge from italy to iran
assessment of the threat of metal exposure to lions panthera leo in east africa

the lion population of east africa is declining due to several reasons and pollution listed as one of the current threats by iucn however no data on exposure routes of pollution from mining on lions in east africa are available and metal pollution in terrestrial ecosystems in east africa is understudied the current proposal aims to fill this gap by looking at both metal exposure in lions and their main prey close to mining areas and in reference areas away from suspected pollution in addition noninvasive sampling of fur will be assessed as biomonitoring tool for metal exposure finally we will provide recommendations to local authorities and communicate our findings to local communities this project will give me the opportunity to apply my previous knowledge on metal pollution in wildlife and to gain new expertise working in african ecosystems and with african communities as well as gain new practical skills such as sampling large carnivores furthermore my supervisors at the norwegian university of science in technology ntnu provide interdisciplinary expertise within ecotoxicology prof jaspers and conservation ecology prof rskaftleothreats main research question is what are the main exposure routes for metals in east african lion populations i hypothesize that lions inhabiting mining sites may be exposed to metals due to the ingestion of contaminated prey and water the exposure to toxic metals may cause adverse effects on their health thus contributing to population declines me and local collaborators will study metal exposure by sampling blood and fur from lions inhabiting areas close to mines as well as from lions ranging areas unsuspected to be contaminated
danube region water lighthouse action

in the danube river basin lives 79 million inhabitants as the danube river management plan indicates the majority 52 of all rivers do not meet the criteria of good chemical status moreover all monitored indicators deteriorated the danube river is an artery of the ecosystems of the whole drb and the region with significant environmental impact the river also has an important economic utilization supporting smes and creating jobs for locals as well as having a cultural importance to properly manage this complex and fragile ecosystem we must think of a river basin and harmonize our actions from the black forest to the black sea dalia danube region water lighthouse action is comprised of 22 expert organizations including universities authorities smes and ngos from 8 different danube eu and associated countries accumulating an outstanding set of knowledge covering not only the basin geographically but all different fields of expertise necessary to deal with the multidisciplinary issues from source to seathe project brings to drb integrated dalia tool which will be integrate into danube mission hub for better decision making to improve drb restoration of fresh and transitional water ecosystems it provides options for strategies and policies that concern freshwater ecosystem protection and ecosystem connectivity in drb and improved protection of local communities and ecosystems from extreme events and pollution threats the dalia project will contribute directly to the establishment of eu and un initiatives related to the further execution on the water framework directive by the execution of innovative actions across a variety of geographies their scaling and the multiplication of outcomes with a wider network of ecosystems and related eu missions and project actions throughout framework
mutational processes and impact of structural variants in somatic cells

mutational processes that generate structural variants sv in human and other genomes are understudied and merit attention and similarly so for the functional impact of the svs on gene function and regulation svs may explain some of the missing heritability in population studies they may provide candidate pathogenic variants in pedigree studies of hereditary diseases as well as constitute yetundiscovered driver events that were anticipated from cancer genomics reasons why the sv mutational processes and sv functional impact are understudied are both of a technical and a conceptual nature both aspects will be addressed in the structomatic project we will study structural variation in human somatic cells by combining diverse computational and experimental approaches drawing on a genomic resource of hundreds of tumors and healthy tissues sequenced using longread wgs that we will generate we will further perform mutation accumulation and directed evolution experiments using cell line models of chromosomal instability generating further genomic data that will support observational analyses of tumor genomes the project aims are thoroughly cataloguing the diversity of svs in multiple somatic cell types including those not detectable by shortread wgs elucidating the underlying mutational mechanisms that generate svs their heterogeneity across the human chromosomes as well as their variation between individuals and developing rigorous statistical methodologies for identifying positive and negative selection on svs in human somatic cells characterizing the landscape of somatic svs is crucial for a more complete understanding of the genetic basis of carcinogenesis and of the variable cancer risk across tissues and individuals and may also provide evidence for hypothesized roles of somatic genetic variation in agingrelated pathologies more generally
new experimental methods for trapping cold molecular hydrogen

due to its simplicity h2 constitutes a perfect tool for testing fundamental physics testing quantum electrodynamics determining fundamental constants or searching for new physics beyond the standard model h2 has a huge advantage over the other simple calculable systems such as h he or hd of having a set of a few hundred ultralong living rovibrational states which implies the ultimate limit for testing fundamental physics with h2 at a relative accuracy level of 1024 the present experiments are far from exploring this huge potential the main reason for this is that h2 in its ground electronic state extremely weakly interacts with electric and magnetic fields hence h2 is not amenable to standard techniques of molecule slowing cooling and trapping in this project we propose a completely new approach for h2 spectroscopy for the first time we will trap a cold sample of h2 we will consider two approaches superconducting magnetic trap and ultrahighpower optical dipole trap with trap depths of the order of 1 mk t 5 k will be achieved with a standard refrigeration technique and the trap will be filled in situ with the 5 k thermal distribution of the h2 sample presently there is no technology available to cool down the h2 gas sample from 5 k to 1 mk hence the only option is to directly capture the coldest fraction the majority of the molecules that initially fill the trap zone will be lost however the high initial h2 density will allow us to trap up to 600 000 molecules we will do infraredultraviolet double resonance h2 spectroscopy referenced to the optical frequency comb and primary frequency standard the ability to do spectroscopy using a cold and trapped sample will eliminate the sources of uncertainty that have limited previous best approaches and will allow us to improve the accuracy by at least two orders of magnitude the h2 traps will open up a new way for further longterm progress in the metrology of h2 rovibrational lines
contextaware adaptive visualizations for critical decision making

we live in an era of information overload that impairs objective decision making especially in timesensitive contexts information visualization infovis systems have been used to mitigate information overload yet they have not yet unlocked their potential in critical decisionmaking scenarios from emergency rooms and autonomous cars to operational command centres a clear understanding and rapid assessment based on the available data can make the difference between life and death symbiotik envisions an effortless interaction dialogue between human and infovis systems to support decision making processes inspired by known biological principles and guided by artificial intelligence ai critically this dialogue requires ai solutions with context awareness emotion sensing and expressing capabilities we propose a novel framework where both the human and the machine cooperate towards a common goal and evolve together awareness principles will allow us to engineer complex systems making them more resilient and more humancentric we will define an integrative approach for awareness engineering and propose a specific open source implementation finally we will demonstrate and validate the role and addedvalue of such an awareness framework in two scenarios supporting novicetoexpert transitions and critical decision making the awareness principles to be developed in this project can support learning adaptation and selfdevelopment of intelligent systems over long periods of time not only in the infovis domain therefore symbiotik has potential to achieve the real breakthroughs needed to bring awareness and emotional intelligence for decisionmaking tasks in computing systems the results of the project will benefit a range of stakeholders from human vision and brain researchers computer scientists citizens as well as research funding bodies and policy makers
soec hydrogen integration and circular use in steelmaking process

facing the urgent challenges of climate change and the necessity for a transition towards more sustainable and efficient energy systems the industrial sector with the steel industry at the forefront is compelled to significantly cut energy consumption and co2 emissions the steel sector accounting for 9 of global anthropogenic co2 emissions and consuming an average of 52 mwh of primary energy per ton of steel produced is at the heart of this challenge the syrius project spanning 54 months aims to revolutionize this landscape by integrating a 42 mwel solid oxide electrolysis cell soec for producing 100 kgh of green hydrogen into a real electric arc furnace eaf plant hydrogen will feed a 280tsteelh 84 mwth slab reheating furnace demonstrating the potential to reduce steel reheating process co2 emissions by 5600 tyear during the project and up to 100 with full hydrogen feeding by generating steam through furnace offgas heat recovery implementing byproduct oxygen recovery in the furnace allowing additional savings of 430 tco2year in syrius and of 2 fuel input in future expansion and analysing options for water recycle syrius seeks to minimize external energy consumption and sets industrial circularity at the project core with a viable business case centred on process integration syrius aims to strongly enhance market opportunities in the short to medium term by driving industrial green hydrogen costs below 22 kg surpassing the sria targets for 2030 by preserving endproduct quality at competitive costs reducing greenhouse gas emissions lowering hydrogen costs and creating new direct and indirect jobs syrius will play a pivotal role in enhancing the circularity of the eu steel sector a firstofitskind trl7 plant ready to be scaled up extended to other industries and replicated globally thanks to the unique geographic coverage of the technology providers in the syrius consortium will showcase innovation in action
era talent platform for career development of researchers in europe

the era talent is a 36 months coordination and support action with the aims to support the implementation of the new era communication and to further develop the services provided by the existing euraxess network with the objective to support the career development of researchers in europe expanding the career trajectories for them in academia industry and businessthe era talent scope will be reached through the establishment of five thematic hubs that are built as onestopshops where researchers find information and support services fed by the competences of the centres in different fields and through six community of practices cop where the centres are grouped under specific themes to exchange experiences and information needed to strengthen their knowledge and expanding their talent management services for researchersthe era talent project will support the euraxess centres to deliver specialised talent management services to improve the employability and mobility schemes for talented researchers last but not least a more fostered culture of entrepreneurship opening new career trajectories for researchers in industry and business will be seek the era talent project involves 34 bhos partners and it will be structured in 6 work packages wp1 project management wp2 communication dissemination and exploitation wp3 hubs framework cocreation and monitoring wp4 knowledge sharing for specialisation in the euraxess network wp5 researchers orientation wp6 digitalisation and data
impact of microplastics originating from formula preparation on protein digestion in infant digestion models

microplastics mps of various morphologies ranging from 1 m 50 mm in size have been ubiquitously detected in the environment food drinking water and biota and may pose a threat to food safety and human health the highest reported concentration of mps comes from the processing of foods in plastic packaging mps exposure to humans is more prevalent in infants than in any other age group due to the use of polypropylene pp based products in formula preparation the difference in food intake and digestive physiology between infants and adults have been indicated as key contributors to the distinct patterns of proteolysis in spite of mps being frequently consumed with food proteins data on the digestion process of cows milk in the presence of mps are not available the broad aim of the proposal is to investigate the effect of mps from plastic packaging material on the digestibility of proteins in adults and infants the project will focus on specific objectives comparative digestibility of cows milk proteins in the presence of mps and aged mps in adult and infant digestion models digestion of infant formulas in the presence of mps in infant digestion modelsthe proposed study will use methodology applied in prior research and harmonised protocols for adult and infant digestion to achieve the proposed aims the researcher will get training through knowhow transfer and research in digestion models protein analysis and digestomics from the university of belgrade faculty of chemistry and get knowledge on mps preparation and characterization during the short visit to maastricht university polymer department the proposed project aims to study an issue that has attracted global attention and therefore the communication and dissemination measures will be oriented both to the scientific society and the wider public the project will generate new knowledge on the impact of mps on human nutrition and provide data that may be adopted by policymakers
fidelis establishing a european network of trustworthy digital repositories

the european open science cloud eosc aims to develop a web of fair findable accessible interoperable reusable data and services for science in europe in order to achieve a sustainable eosc trustworthy digital repositories tdrs providing longterm preservation services are required the fidelis project aims to establish a healthy vibrant and selfsustaining network of tdrs that will foster a supportive open science environment and guarantee fair data sharing also in the future within its threeyear lifetime fidelis will set up develop and operate a european network of trustworthy repositories that will support the development and growth of tdrs within the eosc ecosystem foster harmonisation and interoperability across repositories to enable an eosc federation of tdrs and strengthen the upskilling of repositories and expansion of the network through an active training and support programmethe word fidelis comes from the latin fides and means trustworthy faithful loyal dependable true in ancient rome fides is everything that is required for honour and credibility from fidelity in marriage to contractual arrangements and the obligation soldiers owed to rome it is also the name of the goddess of trust faithfulness and good faith bona fides
cutandpaste conjectures and multicurves

knot theory has seen extraordinary developments over the past decades the arrival of modern homological knot invariants has had farreaching implications beyond lowdimensional topology giving insight into old problems through deep ties between knot theory algebraic geometry representation theory floer theory and physicsmy erc project aims to establish a new perspective on knot homology theories using a new type of invariants socalled multicurves as objects of fukaya categories of simple surfaces these multicurve invariants make local versions of knot homology theories amenable to essentially combinatorial techniques thanks to their exceptional geometric and gluing properties multicurves are ideally suited to implement the divideandconquer principle for attacking hard open problems in fact i have not only been directly involved in the definition of three of these invariants but i have also applied them to resolve several open conjectures in the field alreadythe purpose of my research programme is to investigate fundamental open problems in lowdimensional topology that require a deeper understanding of the new technology of multicurves to this end i will pursue the following four lines of basic research i will investigate the topological properties of the new invariants and their relation to classical invariants i will explore the existence of local versions of various spectral sequences that are known to relate knot homology theories i will make the invariants more computable finally i will apply the generic principles that underlie the definition of multicurves to other settings
preventing therapy resistance in esophageal cancer using advanced models and molecular signatures

in 2035 cancer will have become the leading cause of death in the eu in line with the horizon europe plan to beat cancer one of the five horizon missions the pressure network sets out to train 10 future experts who will push the development and clinical implementation of effective treatments and policies against therapy resistance in cancer this innovative project will specifically focus on esophageal adenocarcinoma as one of the most complex cancer types in terms of resistance and most urgently in need of novel solutions prominent factors that contribute to the poor outcome of esophageal cancer are a high degree of acquired resistance and heterogeneous responses to the available therapies despite this knowledge there are currently no consensus treatments for this disease in the eu and there is insufficient awareness of the need for a unified lowrisk treatment strategy numerous different regimens are currently given across the continent and as a result highly divergent outcomes of eac are observed this adds to cancer inequalities in europe to address this pressure researchers will receive exhaustive intersectoral training and deliver highquality knowledge across the entire value chain epidemiology imaging patientderived model systems resistance mechanisms diagnostics patientcentricity valorization and treatment by receiving this diverse training the esrs will become next generation thinkers and problemsolvers and will be able to deliver creative contributions to all fields involved in the combatting of cancer with unique solutions applicable in the clinic and society this combination of complementary research expertise and rich training is not currently offered in an eu network