Dragon09/odtu_chatbot huggingface dataset:
investigating fictional representations of child sexual abuse in contemporary culture myths and understanding

child sexual abuse csa is a critical issue facing contemporary societies and one which inspires many fictional representations in creative cultural works despite csas prevalence and potentially serious consequences it remains relatively taboo and stakeholders refer to a societal flinch or aversion from engaging with the issue which hinders survivors wellbeing this avoidant response seems to have been inadvertently replicated in literary and cultural studies in which csa as a theme is almost completely overlooked meaning that its full cultural implications are currently unknown the csareps project will address this by exploring the culturally significant but neglected body of works which depict csa examining not only their representational strategies but also their potential role in shaping peoples understandings of csa the objectives are1 to analyse the themes form and emotional cues in csa fictions from key genres crime horror young adult popular general in the culturally prevalent forms of literature film and television providing a foundational mapping of these representations and opening a new and longoverdue research horizon in literary and cultural studies2 to explore how csa fiction may inform social attitudes by performing the first ever empirical investigation of audience responses to it including the general public and csa survivors identifying influence will be challenging but could transform our understanding of how public views on abuse are formed impacting disciplines like psychology and social work for which such knowledge is key3 to develop a new conceptual framework which interlinks thematic and empirical approaches to cultural scholarship to allow the mapping of csa fictions to be related to the audience response findings ultimately yielding a model suggesting the relationship between csa fictions and their effectsthis transferrable framework will support explorations of abuse representations across cultures and media
the evolution of cis and transregulators in eukaryotes

gene regulation plays an essential role in shaping species differences and modulating phenotypes across development and environmental conditions it essentially works through the recruitment of transacting intermediates to cisacting dna sequences affecting the expression of the nearby gene while gene expression regulation is central in molecular cellular developmental and system biology its detailed mechanisms have relatively little been incorporated into modern evolutionary theory i previously discovered two processes specific to gene expression evolution in diploids cisregulator runaway and divergence they arise because of i transient dominance modifications that automatically occur following the evolution of cisacting regulatory elements and ii coevolution of these cisacting elements with transacting regulators i have shown that accounting for these processes calls into question a halfcentury of theory on sex chromosome evolution and may rejuvenate empirical and theoretical work in this field here i will develop the evolutionary theory of cis and transregulators at full scale and empirically test its core features and predictions specifically there are sound reasons to believe that this new theory also has the potential to strongly advance our understanding of other fundamental and enigmatic features of eukaryotic life it may be a crucial missing element to explain the origin of eukaryotic regulatory complexity and how and why sex asex transitions fail or succeed and therefore why eukaryotic sex is maintained regevol offers a new and original approach to important problems in evolutionary biology if successful it will significantly advance our understanding of eukaryotic lifeforms and provide a general framework for gene expression evolution in eukaryotes
radiation harvesting of bioactive peptides from egg proteins and their integration in advanced functional products

radov moves from the wellestablished radiation process applications in food irradiation for disinfection and shelflife increase and from several decades of fundamental studies of the biological effects of radiation in vivo to explore completely new routes for the production of bioactive peptides from egg proteins based on radiationinduced fragmentation and new product prototypes that incorporate egg proteinderived peptideshigh energy radiation from electron accelerators will be used to produce peptides and the collection of the results acquired regarding the peptide structure irradiation conditions and related bioactivity properties will be one vital output of the project to expand the application of ionizing radiation and to demonstrate the broad scope of its applications new products containing bioactive proteins peptides will be designed and developed with the use of electron beam irradiation to manufacture them in particular two target products will be developed as demonstrators of eggderived amps by radiationinduced fragmentation peptideladen antimicrobialantioxidant hydrogel wound dressings and peptidegrafted active food packaging film
revealing the ancient plant ethylene biosynthesis and acc signaling pathway

when ancestral plants colonized the land 450 million years ago they needed to adapt to harsh environmental conditions when giving up their aquatic lifestyle i hypothesize that during this watertoland transition the volatile plant hormone ethylene became an important growth regulator to face terrestrial stressors in fact modernday crops use ethylene to regulate stress responses and perhaps ethylene served this role in pioneering land plants to cope with the harsh conditions coinciding with this habitat transition during my postdoc i showed that ethylene signaling was functionally assembled in ancestral charophyte green algae prior to land colonization now i question why and how early land plants produced ethylene while seed plants make ethylene using acc as precursor nonseed plants follow a different yet unknown ethylene biosynthesis pathway which i want to reveal using the liverwort marchantia polymorpha a model species representing early life on earth i also question why nonseed plants make acc but not use it for ethylene synthesis recent studies revealed that acc itself can act as a signaling molecule independent from ethylene by an unknown signaling pathway to regulate plant development i also postulate that both the alternative ethylene biosynthesis and acc signaling pathway might have an origin in ancient algae prior to land colonization and might be conserved in seed plants possibly exerting important functions yet to be uncovered using functional genetics in representative species of algae and crops ethylution will unravel the importance and role of acc and ethylene that allowed plants to thrive on earth perhaps one of the most impactful events in the evolutionary history of plants
mechanisms of proliferationindependent mutation

dna damage contributes to the ageing of tissues and causes mutations that drive cancer however the molecular mechanisms underlying many mutational processes are not understood and neither is how much they contribute to disease with a powerful new technology i propose to close these major gaps for common clock mutations of unknown originthe recent genome sequencing revolution has revealed unexpected diversity in mutational patterns one pattern in particular is intriguing as it behaves as a molecular clock the number of mutations increases over time and correlates with age although the textbook view of mutagenesis is that cell division is required to convert dna damage into point mutations surprisingly nondividing cells like neurons also accumulate clock mutations as a function of time indicating that clock mutations arise without genome replicationunderstanding how cells mutate independently of proliferationand thus challenging the current paradigm of mutagenesisis a fundamental question that has been hindered because assays to measure mutation require cell division excitingly i have overcome this major obstacle by establishing a powerful strategy to sensitively detect mutations in single cells genomewide my group will combine this approach with targeted genetic manipulations in cells and mice to answer two central questions 1 how do cells mutate independently of proliferation 2 what drives these mutations in tissues my novel insights into endogenous dna damage from mouse genetics and genomics combined with the innovative sequencing strategy that i have established uniquely position me to answer these longstanding questions together the work proposed here will reveal the molecular mechanisms underlying the most common mutational process in humans clock mutation the methods data and insights from these groundbreaking studies will directly impact cancer research and uncover novel sources of dna damage during aging
supporting the potentials of digital datadriven solutions for livestock tracking

eu data governance act and recent advances in technology provide a unique momentum to automate and expand livestock data collection integration and exploitation by strengthening the coordination of efforts of science and industry the ultimate goal of digi4live is to increase the capacity of livestock sector actors across europe to benefit from data generating and digital technologies by using a strong multiactor and cocreation approach which brings together livestock sector actors from farm to fork from science to livestock and technology industries competent authorities and other key actors and engages them in cocreation of digital data concepts digi4live enables greater use of current and new data digital technologies in livestock tracking digi4live is a 45 years coordination and support action that is reaching out to over 1000 organisations and initiatives across europe to make an impact towards economically environmentally and socially sustainable digitalised livestock business that meets consumers expectations more effective public administration and impactful policydigi4live boosts the creation of standards and harmonised regulations thus eliminating technical barriers for data and new datagenerating technologies and provides evidence on economic social and environmental impacts of datadriven solutions in the livestock sector and boosts collaboration between ri initiatives across all eu member states and beyond it will point out how public administration and policy monitoring assessment businesses and consumers can benefit from digital technologies concepts for greater exploitation of data will be codeveloped and examined in six thematic case study hubs and brought to the attention of end users to such an integrated approach can really make a difference by enabling substantially improved use of data for the benefit of science policy and business the project will provide policy and business conclusions
upcycling plastic waste for distributed passive cooling applications

coolchips addresses two grant challenges of our modern society 1 global warming requires new technologies to mitigate the everaccelerating consequences of climate change passive daytime cooling is such an emerging technology that requires intricate photonic engineering of materials 2 plastic waste is evolving as an increasing challenge to keep our environment pollutionfree we therefore will investigate an upcycling strategy to put used foodpackaging polymers to an even better use mitigating global warming consequently we outline synthetic strategies to equip aluminum laminate polymer films widely known for chips bags etc with an additional coating this coating layer combination will be designed so that solar radiance will be fully reflected and thermal radiation in the midinfrared range will be efficiently emitted this unique combination of optical properties is the key to using cold outer space as a heat sink for our environment day and night we will achieve this goal by using our knowledge in polymer and composite materials synthesis and processing we will further develop scalable processing strategies to glue or weld the individual recycling pieces to large passive cooling foils this upcycling is vital for the envisioned transition to enduser products that can then be realized by established rolltoroll processing technologies foreseeable application cases such as covers for tents glueable foils for blinds or standalone parasols will be investigated with established industry partners the development of the required processing steps and material selection will be tightly accompanied by an intellectual property patenting strategy and market analysis to ensure optimum exploitation of this promising novel material development overall coolchips will make passive daytime cooling materials accessible to various communities providing a green and affordable way to cooler environments
pn6047 a breakthrough treatment of neuropathic pain

pharmnovo aims to develop novel drugs with superior clinical properties to treat patients suffering from chronic pain using knowledge and experience in drug design and g proteincoupled receptor pharmacologypharmnovos lead drug candidate is pn6047 a completely new type of opioid drug for neuropathic pain with a firstinclass market potential unlike the currently available opioid drugs which activate all opioid receptors pn6047 is a very selective delta opioid receptor agonist activator due to its unique molecular structure pn6047 selectively activates the g protein signalling pathway while avoiding those leading to unwanted side effects such as the arrestin protein signalling pathway that mediates receptor desensitization and analgesic tolerance and possibly proconvulsant activity pn6047 can be the first of a new drug class for neuropathic pain treatment delta opioidbiased receptor agonists dobras preclinical studies have shown that pn6047 is safe tolerable and effective in treating neuropathic pain and also other painrelated indications such as opioid withdrawal and chronic cough the clinical phase i study has confirmed that pn6047 is safe and tolerable at doses predicted to be efficaciousnow the drug is ready to proceed into a phase iia poc study which is the focus of the proposed accelerator project the confirmation of the clinical efficacy of pn6047 will enable us to enter an outlicensing agreement with one of the major players in the chronic pain market alternatively it would allow us to attract significant equity investments and finance subsequent phase iib and iii clinical trials scale up manufacturing market approval and product launchthis project is of strategic healtheconomic importance for europe about 149 million people in europe suffer from chronic pain including about 298 million neuropathic pain patients in europe the healthcare cost of chronic pain is estimated at over 300bn annually around 15 3 of gdp
modelling the biochemistry of terpene synthases

modbioterp aims to train 10 exceptional candidates in biochemistry aiguided enzyme modeling laboratorydirected evolution and synthetic biology the focus of this project is on the natural product class of terpenoids which are the largest and most chemically diverse class of natural products and hold immense potential for biotechnological applications with the latest eu policy on critical technologies from september 2023 which includes biotechnology and specifically mentions synthetic biology modbioterp is wellpoised to address these challenges terpene synthases tpss are the enzymes responsible for generating the structural diversity found among terpenoid natural products these elegant enzymes mediate complex carbocationbased cyclization and rearrangement cascades with various electronrich linear and cyclic substrates terpenes are abundant in plants bacteria and fungi and also form the basis of all life through sterols and other very basic metabolites the biochemistry of terpene synthases is at the core of modbioterp with the focus on the challenge of translating a given enzyme model into the understanding of the product profiles of terpene synthases and providing a strong product prediction tool based on the enzyme models developed the project will explore and exploit the chemical and biological diversity of terpenoids and develop a new fundamental biochemical understanding of these enzymes ensuring the technological leadership of europe with this project we will unlock the vast potential of terpenoids and lead the way toward sustainable and innovative biotechnological solutions in modbioterp 10 doctoral candidates dcs will spend their research and training time in academic and industrial groups that are global leaders in the field of terpenoid biochemistry and enzyme modeling all dcs will also spend time with secondment partners to learn new techniques and be immersed in different scientific environments
robotics and artificial intelligence for critical asset monitoring

this project aims to develop technologies which will enhance the operational capabilities of mobile robots for use in the inspection and maintenance of industrial facilities a major task in many industrial environments is the retrieval of samples for chemical or biological analysis surface swabbing is often conducted manually but this creates limits on the number of samples that can be taken and their location there are often many places that cant be reached by people either due to the location very high or in confinedrestricted access spaces or environmental hazardous such as heat or radiationthis project will develop a multidomain multiagent robotic sample retrieval system that will be able to obtain samples across a range of environments these samples will either be stored for exsitu analysis in labs or taken to mobile labs for insitu realtime analysed due to the nature of the operational environments full autonomy is not desirable so shared autonomy humanintheloop will be required the primary application focus will be nuclear environments however the technologies will be applicable to many other sectors include petrochemical offshore and agriculture
wave energy demonstration at utility scale to enable arrays

wedusea led by irish wave energy developer ocean energy will demonstrate a grid connected 1mw oe35 floating wave energy converter known as the oe buoy at the european marine energy test site emec in orkney scotland this rigorous technical and environmental demonstration will happen over a 2 year period in atlantic wave conditions with outcomes directly impacting policy technical standards public perception and investor confidence the project will demonstrate that the technology is on a cost reduction trajectory in line with the eu set plan targets and will be a stepping stone to larger commercial array scale up and further industrialisation the action will integrate sub components such as moorings and ptos improving efficiency reliability scalability sustainability and circularity of the technology the combined actions of the work programme are expected to reduce the lcoe for the technology from 361mwh to 245mwh a 32 reduction for a 20mw array the lcoe would reduce from 185mwh to 127mwhthe project has 3 clear phases phase 1 the initial design phase leading into a gono go phase 2 demonstration in which it is expected that the baseline device will generate in excess of 1650 mwh over the deployment and phase 3 commercialisation and dissemination which sees the capitalisation and exploitation of the results ocean energy and other consortium companies will actively exploit the results through new innovations products and services the results will be disseminated to feed both environmental databases and iec electrotechnical standards this action will take wave energy beyond the state of the art building on the partners experience in prior eu projects enabling arrays of reliable devices to achieve the 1gw target set out in the 2030 dgener offshore renewable energy strategy planned engagement will create more public perception empower and inform policy makers and derisk larger scale investments to meet the 2050 targets
deciphering mineralogical and compositional properties of kidney stones implications for formation mechanism and potential treatments

kidney stone disease is a vital health problem with a significant increase in prevalence worldwide it is known that kidney stone formation is affected by medical conditions ie diabetes environmental factors dietary habits and gender although the relationship between the stone mineralogical and chemical properties eg crystal structure elemental composition etc to the urine and blood parameters are still unclear notably there is limited information on how the kidney stone mineral phase is influenced by the organic compounds of body fluids during growth and dissolution likewise the kidney stone isotope composition will be recorded during its formation and subsequently can be used as an indicator of dietary habits environmental factors and identifying underlying diseases eg diabetes osteoporosis mikidston aims to perform a systematic study from macro to nanoscale on a large array of different types of kidney stone samples to assess i the influence of the body fluid urine and blood parameters as recorded in patients on the characteristics of kidney stone biomineral phases ii the relationship of the chemicalisotope composition of kidney stones to their structure and risk factors eg diet environment diabetes etc and iii the controlling factors for stone formation and dissolution these objectives will be achieved combining applicants expertise and that of pis from the two host institutions on mineralogical and isotope analyses the outcomes will shed light on connection between kidney stone structure composition growth and dissolution with physiological parameters for patients with urolithiasis with important implications for accurate diagnosis and effective treatment strategies finally mikidston findings will have important implications for future pathological biomineral investigation using cuttingedge techniques and most importantly for the study of other stonerelated human diseases eg gallstones
multicomponent supramolecular structures as artificial enzyme mimics

supramolecular polymers sps are at the forefront of current research to functional biomimetic materials and systems among the plethora of sps appeared in the literature in the last decades those based on 135benzenetricarboxyamide bta which have shown to form double helical fibres both in organic and aqueous solution have been employed as a robust platform for the design of bioinspired materials with tailored and tuneable properties indeed noncovalent synthesis allows to easily obtain a wide range of functional sps by simply mixing chemically distinct monomers in solution which will spontaneously selfassemble into dynamic structures such approach has been exploited to develop btabased sps able to bind nucleic acids in a superselective fashion through multivalent interactions between positively charged coassembled bta monomers and the phosphate present in the oligonucleotide backbone building on these previous findings must artem aims to develop functional sps to be exploited as artificial nucleases able to recognize and cleave rna the recognition and the hydrolytic activity are provided by cationic components bearing the 147triazacyclononanezinc complexes tacnzn2 which is well known to catalyse the hydrolysis of phosphodiester bonds the positively charged components undergo clustered upon binding with the oligonucleotide thus enhancing the hydrolytic ability of the zinc complex through cooperative catalysis once degraded the rna is no more able to induce clustering of the functional monomers which will come back to the initial random distribution switching off the catalytic ability of the fibres such functional sps will be then tested in more complex systems to trigger downstream selfassembly of dna structures finally liquidliquid phase separation of the functional sps will be achieved developing bioinspired compartmentalized hydrolytic microreactors