Dragon09/odtu_chatbot huggingface dataset:
miniaturised respiratory assist to treat acute lung failure patients using a breakthrough hyperbaric technology

acute lung failure alf is the third leading cause of death globally and is characterised by severe respiratory impairment when noninvasive ventilation niv fails the treatment escalates to invasive mechanical ventilation imv the current standard of care for alf imv is highly invasive with a high risk of complications and an avg inhospital mortality rate of 35 costing thousands of euros per patient hospitals have signalled an unmet need for safe and adequate alternatives to imv in alf hbox therapies gmbh is bringing mira miniaturised respiratory assist to market a disruptive and innovative hyperoxygenation therapy that combines unrivalled blood oxygenation and co2 removal to treat alf patients while they are awake such a breakthrough therapy has the potential to be the first treatment option for alf patients who fail niv mira therapy has an outstanding costeffectiveness and improved patient outcomes by avoiding or limiting the need for imv and further respiratory deterioration in these patients the growing incidence prevalence of respiratory diseases causing alf suggests that there are up to 6 million alf patients who could benefit from mira every year representing a market potential of 104 byear behind mira there is our extracorporeal hyperbaric blood oxygenation hbox technology 2 patents protect the technology and the approach hbox has been validated in animal trials trl 5 and we now need to i finalise the integrated system for improved safety efficacy ii complete clinical studies and iii obtain mdrce certification for the mira medical device to commence commercialisation we expect the results of the mira project to accelerate the market entry of hbox and to serve as a platform technology for additional clinical applications in the future the eic support will be key for our company to establish itself as a leading company in the respiratory industry
rapid affordable microbiota analysis at the point of need

with the pressing demand of precision medicine and the catastrophic damage to microbiological ecosystems following organic processing and global warming there is a critical need to rapidly characterise microbiota directly at the point of need and observe their potential drifts in real time to correct them in a timely manner we recently observed an explosive growth of the microbiota market 30 cagr with analyses relying on culture metagenomics or proteomics however all the available solutions are far too long to process and unadapted to operate at the point of needbforcure has developed the first device ever enabling rapid affordable microbiota analysis at the point of need raman for a comprehensive microbiota test result in just 10 minthe raman project aims at 1 maturing technologies from trl4 to trl 6 2 developing two microbiota universal tests for vaginal microbiota critical during deliveries with 4 of problematic births worldwide and fermentation microbiota responsible for the loss of up to 25 of the production with organic transformationstrong demand from endusers and increasing legislation on the spread of microbiological risks make this an ideal time for our project bforcure has developed a set of 4 breakthrough micronanobio technologies that once combined unlock for the first time the possibility of bringing microbiota tests at the point of need giving a strong competitive advantage on a 119b marketbforcure is a dynamic company which has already demonstrated the successful development and commercialization of a microfluidic medical device in just 3 years our direct contact with the market and our agility of development make us the perfect team to build marketdriven products with disruptive technologies which is crucial to create new marketsonce industrialised our solution will enable bforcure and its customers to harness the power of the microbiota in many other contexts in health agrifood industry and wellness
create a symbiosis where pv and agriculture can have a mutually beneficial relationship

the decarbonisation of the energy sector is one of the top priorities at various political levels including at the european level photovoltaics pv is widely seen as one of the key technologies to drive the energy transition the difficulties arise when the targets for pv usually set at national level needs to be put into practice at regional local level although the pv rooftop potential is extremely large and could potentially contribute to the ambitious targets the rate of installation of pv rooftop systems will not be fast enough to support a rapid transition on the other hand large utilityscale pv installations in open fields are not an option in many regions it is in this context that the concept of agrivoltaics is emerging what several decades of efforts developing building integrated pv bipv products and systems for rooftops and facades have taught us is that there are multiple levels of integration and various stakeholders across the value chain which can all generate significant barriers to widespread adoption agrivoltaics is in fact in the unique position to learn from the past mistakes made with bipv which delayed the development of costeffective bipv solutions and market acceptance in symbiosyst we will not develop solutions that are highly customized as this would drive the costs up we will rather innovate by adapting standardized costeffective solutions in terms of pv modules mounting structures and operation and maintenance om practices to the specific needs of various crops in different climates and landscapes we will also find aesthetically pleasing solutions that can be mass manufactured and integrated with the agricultural land in a harmonious way while maintaining the primary goal of farming the interdisciplinary consortium in symbiosyst is composed of partners across the value chain with decades of experience in agriculture precision farming pv modules and systems social science and integrated pv applications
the hydrocup a hollow electrospun scaffold for in vivo cellladen hydrogel delivery

secreted cytokines by transplanted cells can have positive effects such as immunomodulation angiogenesis and tissue regeneration however transplanted cells are difficult to retain in a specific place to maximize the release of cytokines on site here we developed a hollow electrospun scaffold with one open and one closed end for the in vivo delivery of cells as secretory factories in a hydrogel termed the hydrocup because of the closed end a cellladen hydrogel can easily be dispensed into the open end of the hydrocup after which the open end is closed with sutures as part of the erc starting grant where this application stems from we showed that adult stem cells encapsulated inside the hydrocups remained viable for 28 days in vitro and released functional cytokines similar to hmscs in hydrogels alone in addition the hydrocups remained intact and fixed in place for 6 weeks after subcutaneous implantation in rats in this erc proof of concept proposal we aim at further studying the hydrocup as a device for a wide variety of cellbased cytokine secretion or drugladen hydrogel applications we will further refine the device for applications in the cardiac regeneration market where stem cell based therapies suffer so far from low viability of cells after injection we will make a market analysis study of competitors in the cell therapy field and propose an initial business plan for seeking further investments to create a spinoff company at the end of the grant
smart sensor analog frontend powered by emerging reconfigurable devices

our main objective is the development of a reconfigurable platform to accommodate both for a generic sensor interface as well as a dedicated sensor transducer element the tunable analog frontend afe interface should be enabled at the finegrain level by emerging reconfigurable field effect transistor rfet and negative differential resistance ndr transistor technologies that provide cointegration capabilities with european 22nm cmos processing technologies allowing for a morethanmoore sensor technology approach being dopingfree these two key enabling technologies provide a high potential gain for a large variety of sensor system requiring a low 1f noise behavior ranging from solidstate sensors such as photodiodes to environmental monitoring for the automotive market and physiological signal monitoring such as cancer detection having naturally ungated channel areas reconfigurable field effect transistors are the perfect target vehicle for functionalized surfaces eg for the detection of colorectal cancer crc biomarkers serving as a reconfigurable sensor transducer rst for the healthcare sector together with the afe these transducers can be integrated into a cmos as a usecase demonstration of the flexible platform to sum up in sensoteric we will investigate smart sensing solutions in environmental monitoring and healthcare where both the rst and the afe utilize the capabilities of emerging rfet and ndr key enabling technologies
decocherence of levitated microscopic particles in extreme isolation

one of the most intriguing features of quantum mechanics is the superposition principle which allows a quantum object to be in two classically distinguishable states at the same time levitated objects like nanoparticles are an exciting platform to put the superposition principle at test with simultaneously large masses and delocalization distances recently in 2020 and 2021 the center of mass motion of a levitated nanoparticle was experimentally cooled down to the quantum regime to achieve this milestone the experiment had to be performed in extreme isolation conditions eg ultrahigh vacuum now the field faces the challenge to promote the highpurity quantum ground state cooled state of the nanoparticle to a more complex quantum state which can be subsequently used for applications decoxtreme is a multidisciplinary study devoted to provide the theoretical framework that allows to push the experiments with levitated nanoparticles deep in the quantum regime by improving the current theoretical description of decoherence envisioning strategies to mitigate its effects and certifying the quantum properties of the observed quantum phenomena to achieve this goal we propose to promote the description of decoherence to move beyond the memoryless and continous noise approximations to design decoherence protected states exploiting collective properties of levitated objects and to analyze how to quantumness has to be certified in extreme isolation conditions if successful our rigorous theoretical analysis combined with the corresponding experimentally realistic constraints will uncover the path to longer lifetimes for quantum superpositions and ultimately lead to a better understanding of the nature of quantum phenomena
investigation of host factors regulating virus proliferation in plant stem cells and germline

with this proposal i will address a longknown but still not understood phenomenon in plant virology despite extreme replication rates in infected somatic tissues many plant viruses are excluded from stem cells in the shoot apical meristem and subsequently from the progeny of flowering plants suggesting that reproductive cells possess an exceptionally efficient antiviral defense yet some viruses overcome this barrier and pose a substantial agricultural risk of spreading viral diseases through seeds over great distances insight into the molecular basis of virus exclusion from stem cells and germlineprogeny is therefore of utmost importance recent work by the host group leader indicates that rna interference and plant defense hormones prevent viruses from entering the meristematic stem cells if this exclusion is sufficient to prevent virus entry to the germline which factors restrict seed transmission of different viruses and at what stage of development they are relevant will be addressed in this action by two independent unbiased screens first i will identify candidates regulating virus exclusion from plant germlines and vertical transmission by performing cellspecific transcriptomic analysis of gametes from healthy and infected plants aiming to identify enriched and depleted transcripts suggesting involvement of their products in antiviral defense second i will compare viral seed transmission rates in natural accessions of arabidopsis to perform a genomewide association study and identify underlying genomic polymorphisms the proposed work is expected to deliver groundbreaking insight into the mechanisms of transgenerational antiviral defense and novel mechanisms of antiviral immunity with a high potential to contribute to disease control in plants
light elements in the core

since the discovery of the earths internal structure and the existence of a dense metallic core about a century ago the idea of iron being the dominant component of the core gained firm support confirmed by cosmochemical and geochemical observations seismic data the theory of geomagnetism and highpressure studies however although closely matching the velocities of seismic waves traveling through the core are significantly slower than those in a pure ironnickel alloy the observed core density and velocity deficit suggest that around 37 wt of the light elements should be present in the inner core in order to explain the observed mismatch moreover the inner core is anisotropic with the compressional waves traveling faster along the polar axis than in the equatorial plane thus the candidate material should be also able to explain the observed anisotropic patternnonetheless the nature of the light elements in the core remains unconstrained with hydrogen carbon oxygen silicon and sulfur being the most plausible candidates the laboratory measurements on the physical properties of some candidate materials at high pressures and room temperature are available in the literature but data at simultaneous high pressures and temperatures as most relevant to the earth core are almost absentin lecor we aim to identify the most plausible candidate element extending stateoftheart measurement techniques considerably in particular we will study the elasticity and plastic deformation mechanisms of candidate binary and ternary iron alloys and compounds in situ at extreme pressuretemperature conditions using a combination of stateoftheart synchrotron xray techniques developed in our group we will interpret this novel data within the most recent geophysical and geochemical models to better determine the composition of the earths core such would open fascinating avenues to refine theories about the formation of planets in general
deeplearning for structurebased discovery of adaptive immune receptors

b and t cell adaptive immune receptor air repertoires are highly diverse enabling response to a wide range of pathogens while sequencing of an individuals immune repertoires is becoming common our ability to convert these datasets into comprehensive antigen exposure information to inform clinical decisions is limited the major challenges are to identify the antigens recognized by bcell and tcell immune receptors bcrsantibodies and tcrs model their structures and determine their epitopes experimental approaches for epitope mapping are costly and lowthroughput while deep learningbased models have revolutionized structural biology by predicting highly accurate structures of proteins and protein complexes they rely on multiple sequence alignments msas that are not available for the airantigen interactions recently my group has designed geometric deep learning models for air structure modeling and for epitope prediction without msa in this project i will build on my expertise in modeling proteinprotein interactions including airantigen and in geometric deep learning to develop accurate and highthroughput models that address the specific challenges of airantigen systems my main goals are to develop deep learningbased models for i accurate and highthroughput endtoend structure modeling of airantigen interactions ii design of epitopespecific airs for targeting broadly neutralizing epitopes and optimized antigenicity profiles and iii structurebased specificity prediction for mining large air repertoiresthese approaches will advance the analysis of immune repertoires improve our understanding of immune response and enable designing vaccines and therapeutics with broad specificity and resistance to antigenic mutations moreover the methods will empower the cancer epitope discovery and the detection of autoimmune receptors
receptorfocused interventions against orthoflavivirus neuroinvasion and entry

refine confronts the escalating challenge of mosquitoborne orthoflavivirus infections focusing on west nile and usutu viruses as emergent threats to european public health the overall goal is to identify novel targets for therapeutics and to deliver a suite of validated models to assess efficacy and safety of novel compounds antibodies inhibitors and vaccine candidate targets for phase i clinical trials in the first of its six experimental objectives refine characterizes genomic diversity of orthoflaviviruses to select representative clinically relevant strains a unique strength of the proposal is the extensive suite of model assays objective 2 designed to unravel the complex dynamics of virushost interactions at each step of the infection pathway these assays form a basis for receptor and pathway characterisation objective 3 objective 4 aims to asses both efficacy and safety of novel intervention strategies targeting these receptors and pathways based on nanobodies peptides and monoclonal antibodies objective 5 studies the key infection steps and putative receptors in humans utilizing previously collected patient samples to ensure realworld applicability of developed strategies ultimately objective 6 is to integrate knowledge gained to establish a robust and sustainable platform capable of rapid validation of new therapeutic interventions the overall mission of refine is to significantly enhance europes preparedness and response abilities against the expected wave of mosquitoborne viral diseases the team members share a lifelong commitment to advancing our understanding of the molecular mechanisms underlying various aspects of hostpathogen interactions at the humananimalenvironment interface together the refine team embodies a comprehensive approach to address one of the priority health security concerns of our time by delivering effective and safe countermeasures against emergent viral pathogens in europe
anthropogenic environments in the future tense loss change and hope in postsoviet industrial landscapes

driving from the airport towards the kazakh capital nursultan will carry the passenger past the new expo building with its permanent exhibition on kazakhstans bright future of smart green energy while in the distance the skyscraper silhouette of the ultramodern city centre is clouded in smog in kazakhstan as elsewhere in central asia the future of the countrys industrial heritage polarises the public in the 20th century central asia was transformed into a hub of rapid industrialisation but mining and industrial towns experienced a critical time with collapsing industries and infrastructure during the 1990s this not only left people economically vulnerable but touched at the very core of local identity in a sociocultural setting where urbanity epitomises civilisation modernity culturedness and wellbeing simultaneously the environmental costs of resource extraction and industrial production became visible calls for a global shift towards reducing environmental impact also resonate in postsocialist countries often in a topdown manner the voices of those living in and with these places are rarely heard juxtaposing different experiences raises questions of environmental justice future livelihoods and feelings of nostalgia for different pasts this is where antheft comes in antheft pursues three objectives at the interface of work and environment in polluted landscapes 1 identify temporalities affects futures and memory 2 describe discursive strategies by which local communities express and make sense of their socioeconomic and environmental histories and identities 3 analyse local understandings and moralities of environmental damage progress good living and placemaking antheft is a groundbreaking project that proposes to venture into a long dure translocal research on central asian industrial work and environment from the late 18th century to the present incorporating disparate memories perspectives and experiences
hydride and hydrogen transfer activity in enzymatic and nonenzymatic systems through the lens of threecomponent thermodynamics study of the role of enzymatic microenvironments

the crucial step for selective cleavage and formation of ch bonds is a concerted transfer of proton pt and electrons et hydrogen atom abstraction haa or hydride transfer ht the haa and ht processes can be employed to various chemical transformations from activation of inert bonds to reduction of co2 this approach however requires a strict control of the regioselectivity of the reaction notably enzymes catalysts developed by nature are characterised by high activity and selectivity in this project we would like to provide insight into the interplay of reaction thermodynamics and sterics given by the microenvironment of prototypical enzymatic active sites employing haa or ht as a key step in catalysis and to decipher which of these effects is more important in enzymatic selectivitythe focal point of the project is the novel three component thermodynamicbased model for reactivity developed for concerted he abstraction the model captures the coupled nature of pt and et by the relative magnitutes of redox potentials and acidity constants of the reactants their values determine not only the the reaction driving force but also the two novel contributions asynchronicity and frustration with opposing effects on the barrier for the reaction an asynchronous process featuring a large disparity in et and pt components of the reaction driving force is more efficient in contrast a common large size of these et and pt components makes haa more frustrated and hence less effectivebased on this model we would like to look into systems capable of co2 reduction and ch bond activation to assess to what extent their reactivity is tweaked by the local conditions given by the enzymatic microenvironment versus the canonical factors affecting enzymatic activity such as sterics and specific interactions the studies may serve as a guide for design for systems capable of effective reduction of co2 and rational redesign of ch activating enzymes