Dragon09/odtu_chatbot huggingface dataset:
surface transfer of pathogens

the stop project will develop antimicrobial and antiviral nanocoatings that can be flexibly or permanently applied to hightouch surfaces these nanocoatings will be derived from a combination of inorganic nanoparticles antimicrobial peptides and nanoscale laser surface patterning the nanocoatings will be thoroughly characterised for their efficacy using both existing international standards and improved testing methods developed within the project the new testing methods will be proposed to standards agencies for adoption several different active substances will be explored i to allow formulation in highly flexible sprayable and longlasting coatings ii provide broad spectrum antimicrobial antiviral activity and iii reduce the chances of the development of resistance to this end the modeofaction and the risk of selection for antimicrobial resistance in bacteria and viruses will be assessedthe flexible nanocoatings will provide a longlasting 30 days reduction in bioburden that resembles standards set for microbial colonization of surfaces in hospitals which can only be reached after intense surface disinfection or permanent introduction of known antimicrobial material such as copper this effect will be studied in a reallife intervention trail and with epidemiological models the developed nanocoatings are expected to lead to significant reductions in infectious diseases transmitted from hightouch surfaces healthcare cost savings reduction in environmental pollution by disinfectants and increased preparedness of the eu public health system to future pandemics the safety of the nanomaterials will be backed up by human and environmental toxicity studies and life cycle analyses from the beginning attention will be paid to enduser acceptance manufacturing scalability and shortterm exploitation by smes
mechanised reverse mathematics in the calculus of inductive constructions

foundations of mathematics labels the centuriesold interdisciplinary vision to secure the logical basis for mathematics and its applications gödels celebrated completeness theorem for firstorder logic identifying semantic truth with syntactic deduction is a key result heralding the formal phase of that vision yet this and other foundational results have not been fully characterised regarding their logical strength and computational content limiting their understanding and applicabilitythe meremath project aims at closing this gap by systematically employing computer mechanisation to the programme of reverse mathematics the ongoing effort to identify the exact logical principles underlying completeness and other results for this analysis the project will use the calculus of inductive constructions cic as a logical base system embodying an agnostic intuitionistic base system unveiling fine logical structure and the coq proof assistant an interactive software tool for modelling logical reasoning and its computational contentspecifically continuing previous research of the experienced researcher er and the supervisor the meremath project will contribute the first comprehensive constructive and computational analysis of the completeness theorem taking into account all dimensions relevant to its logical strength and implementing modularly mechanised proofs as executable coq code by further accommodating a similar analysis of the related löwenheimskolem theorems and other results in the canon the main outcome of the meremath project will be a welldesigned collaboratively developed coq library for constructive reverse mathematics with novel logical observations and mechanisation techniques developed on the wayhosted at the irif lab in paris the project will be developed in the centre of the original creation of cic and coq providing a worldclass environment for the projects aims and the ers academic career prospects
higherorder networks and dynamics

many systems that govern our everyday livesfrom communication networks to the human braincan be seen as networks of interconnected units traditionally networks are equated with graphs where edges give pairwise relations between two units however in network dynamical systems nonlinear higherorder interactions between more than two units often play a critical role in shaping the collective dynamical behaviour of all units for example the spread of a disease depends not only on our behaviour as pairs of individuals but also how we behave in groups of more than two thus elucidating the role of these higherorder interactions is critical to understand and control the dynamics of complex systems that determine our lives and livelihoods whether it is the spreading of a disease or the proper functioning of the human brain as a network of billions of neuronsthe doctoral network beyondtheedge will identify the role of nonpairwise higherorder interactions in the emergence of complex dynamical behaviour of networks of interacting units beyondtheedge brings together key researchers in an international network that is interdisciplinary from mathematics to neuroscience and intersectorial including academia private research institutes and industry to develop new mathematical insights relevant for realworld problems beyondtheedge will train a cohort of 10 phd students through research education and complementary skills training this will enable the phd students to innovate collaborate and become leading professionals in academia industry or the public sector innovative training activities will ensure that all phd students can apply their skills beyond the academic context and put them in perspective of the wider world supervisor training activities ensure that the more junior project partners can shape the phd education of the future thus beyondtheedge will make a lasting contribution that will far outlive the duration of the project
building resilient individuals through effective gradual educational transitions

given the high number of early school leavers and the growing inequalities it appears that our education systems still fail to provide inclusive quality education and equal opportunities for effective educational transitions therefore a multidisciplinary consortium of five experienced and leading research groups from five european research universities and a ngo with a strong track record on dissemination and implementation proposes the bridge research project the bridges project overarching aim is to improve participation and completion rates in upper secondary and tertiary education in europe and to promote more effective educational choices by providing rigorous evidence on policies and practices that promote betterinformed and more effective education and labour market transitions additionally we pay special attention to two recent challenges as we deepen the understanding on the longterm impact of the covid19 crisis and how international student and graduate mobility strengthens education and economies to this end bridge leverages unique datasets providing valuable insights into both cognitive and noncognitive aspects of schooling transitions working closely with education stakeholders and using stateoftheart quantitative and qualitative methods the bridge project assesses the impact of education and training policies on enhancing learning attainments and labour market performance ultimately as an impactdriven research project bridge is committed to producing robust recommendations for education and training policies which will strengthen quality education and result in less inequality in europe
organization of longrange inputs in sensory cortex for topdown modulation of tactile perception

the sensory cortex plays a crucial role in detecting and interpreting environmental stimuli tactile inputs from the peripheral organs are transmitted through the thalamus to the primary somatosensory cortex s1 where they are integrated with longrange projections from higherorder brain regions defined as feedback topdown inputs topdown control has been proposed to mediate contextual or attentional modulation of sensory processing the host laboratory has shown that layer 5 pyramidal neurons l5pns in s1 exhibited dendritic regenerative potentials socalled calcium spikes when mice detect tactile stimuli and their manipulation altered the mouses perception threshold interestingly the l5pns distalapical dendrites where calcium spikes originate are extensively innervated by axonal projections from higherorder cortical and thalamic areas in light of this evidence i hypothesize that longrange inputs to s1 modulate tactile detection via facilitating dendritic calcium spikes in l5pns to test this hypothesis i will determine the localization and timing of the longrange feedback inputs reaching the apical dendrites of s1 l5pns which covary with the tactile detection sensitivity furthermore i will test the context dependence of the longrange inputs i will employ a whisker detection paradigm where mice are trained to detect single whisker deflections to obtain water rewards i will combine onephoton widefield imaging and stateoftheart genetic tools to visualize the glutamatergic inputs in distal dendrites or the axonal calcium activity in longrange projections my study will provide new insights into the neuronal mechanisms underlying contextual modulation of perception by shedding light on the integrative properties of cortical pyramidal neuron dendrites
eufarmbook supporting knowledge exchange between all akis actors in the european union

the current state of the art is that the project euraknos has analyzed the knowledge of 28 horizon funded thematic networks tns and linked operational groups ogs and developed a vision and guidelines for a digital knowledge reservoir for an euwide agriculture and forestry practice eureka has continued this effort by examining 120 horizon funded ma projects within the eipagri and developing a proof of concept of such a knowledge reservoir building on the results of the euraknos projecteufarmbook will capitalize on the results of euraknos and eureka making the data taken up in the platform more fair and adding necessary functionalities to the platform based on the users needs such as interactive peer to peer interaction and user content evaluation tools moreover eufarmbook will assure the linkage to traditional dissemination channels such as agricultural journals on farm demo activities and training and education initiatives the eufarmbook will therefore work closely with associations of journalists enaj educational and training institutions and strengthen the ties with eipagri service point the effort will also be expanded by looking beyond h2020 and horizon europe funded projects and ogs through linkage and interoperability with national and regional initiatives during the whole project an intensive dialogue will be maintained with akis coordination offices and cap networks in all msthe aim is that during the first stage of the project the concept of the platform will evolve to an exploitable product that will stimulate the exchange and collaboration between the akis actors at an eu wide scale targeted and efficient management of data and information to support agriculture and forestry practice from different sources will not only support the cap but also the green deal and farm to fork objectives and targets ultimately resulting in innovation for an environmentally socially and economically sustainable agriculture and forestry
organising fisa and euradwaste 2022 conference under the french presidency of the eu council

the fisaeuradwaste event is a highlevel research policy joint conference on the outcomes and perspectives for the euratom research and training programme this 10th edition of the conference will be held in lyon france from may 30 to june 3 2022 under the auspices of the french presidency of the council of the eu first semester of 2022the organisers of this conference are the commissariat lnergie atomique et aux nergies alternatives cea the most important european research centre in nuclear energy field and the european commission dgrtd with a significant contribution of andra national agency for the management of radioactive waste snetp sustainable nuclear energy technological platform sfen french nuclear energy society and nuclear valleyunder the control of the ministry of ecology sustainable development and energy mtes and in cooperation with the ministry of higher education research innovation mesri and the ministry for europe and foreign affairs meaefisa 2022 and euradwaste 22 conference objectives are to present progress and key achievements of the latest projects carried out since 2018 as part of the euratom programmes to stimulate discussions on the state of play of rd key challenges addressed at national european and international levels on research and innovation policies synergies and partnerships benefitting research and innovation programmes and future perspectivesexpected impacts thanks to an ambitious communication and dessimination action plan are increasing visibility of the euratom research and training programme increasing awareness on nuclear research achievements networking eu stakeholders bringing new research project ideas and collaboration between different stakeholders orienting research development and innovation orientations at the eu level increasing the visibility of national research potential and participation in the euratom framework programme
smart health innovation future technologies hub

shifthub aims to establish a paneuropean smart health innovation hub bringing together a rich network of multidisciplinary stakeholders across the dimensions of the quadruple helix with the mission to facilitate the development ensure the promotion and foster the uptake of smart health technologies and services shifthub will develop and test with the community a complete service offer integrating networking and matchmaking identification of partners and support for procurement guidance for access to funding research infrastructures and scientific expertisein complement to a complete service offer based on jrcs guidelines for the establishment of dihs shifthubs differentiating factors consist in1 an immersive approach to involve patients and citizens in the cocreation process based on the living lab methodology coupled to an online gamification based elearning journey allowing to raise awareness increase literacy and foster the adoption of smart health solutions2 an approach based open innovation to foster a collaborative demanddriven and smeinclusive development and uptake of smart health solutions in a ecosystem of multidisciplinary stakeholders 3 a technical platform pilot including a health data hub a smart health apps repository and an online marketplace to support the experimental development based on a secure and interoperable access to data and showcase a portfolio of solutions developed by the community membersshifthub will identify a pool of 100 high potential smart health apps that will be assessed by at least 300 patients and citizens during 5 living lab events 1500 users online and will be connected to at least 50 healthcare organizations for further uptake
transition metaluranium flps for the cooperative activation of dinitrogen

the proposal entitled trufa transition metaluranium flps for the cooperative activation and functionalisation of dinitrogen will be developed by the candidate at the cole polytechnique fdrale de lausanne epfl switzerland outgoing phase and at the university of seville spain incoming phase under the supervision of prof marinella mazzanti and dr jess campos respectivelythe goal of the proposal is to develop cooperative transition metaluranium functionalisation catalysts by exploiting a frustrated lewis pair approach the isolation of transition metaluranium bridged dinitrogen complexes would represent a fundament development in inorganic chemistry as well as provide access to a range of studies concerning the cleavage of the nn bond and the catalytic formation of nh and nc bonds en route to ammonia and organonitrogen compounds respectively
achieving netzero through innovation in small and medium sized cities

smcnetzero brings together six successful urban innovation initiatives in europe with seven 7 regional and paneuropean networks and their partners to create a satellite network of innovation actors to support public sector representatives from small and mediumsized cities smcs smes academia ngos and investors across europe to facilitate decarbonisation in smcs smcnetzero will leverage its diverse satellite network to gain an indepth understanding of smc needs and barriers raise awareness and simplify access to existing successful initiatives supporting decarbonisation support matchmaking between supply and demand sides by linking smes researchers and investors with smcs and help identify and open access to funding for enabling innovation deployment in smcs currently underrepresented in the european innovation ecosystem smcnetzero is unique in that its diverse consortium partners and broad commitment from target stakeholders in the satellite network ensure focus in regions with less innovation capacity with written confirmed commitment from nearly 100 innovation actors at the proposal stage to participate in the activities including an emphasis on largely underrepresented regions and stakeholders smcnetzeros vision is to create and strengthen local innovation ecosystems interrelations in smcnetzero regions through brokerage and knowledgebuilding activities as well as digital resources to increase capacity for planning deploying and scalingup of decarbonisation solutions overall focusing on increasing the inclusivity of these innovation ecosystems and minimizing existing innovation divides
metrofoodri early phase implementation

metrofoodri is a distributed research infrastructure ri that promotes scientific excellence in food quality and safety it provides metrology services in food and nutrition across various highly interdisciplinary interconnected fields along the food value chain such as agrifood sustainable development food safety quality traceability and authenticity environmental safety and human health in may 2022 it completed its preparatory phase upon the h2020 metrofoodpp project ga871083 however a few bottlenecks were identified in the final evaluation report furthermore the consortium prepared plans for the next short and mediumterm phases and the board of governmental representatives proposed several suggestions metrofoodepi was established with the overarching mission to build metrofoodri as an infrastructure consolidated for its full implementation and to begin the operational phase addressing any critical issues four specific objectives have been identified support the establishment of the legal entity that will manage the ri specify the technical implementation of the ri as serviceoriented consolidate its position in the landscape and secure longterm sustainability metrofoodepi will act on four layers covering eric setup including membership consolidation governance establishment securing funding and distributed architecture technical organisation and implementation of the ri for its operation including a definition of user requirement specifications for the ecomponent and setup of the core components data management solutions access and services consolidation of the ris positioning in the agrifood research innovation landscape including an update of the scientific strategy and contribution to the era community building and liaising with other complementary initiatives longterm scientific financial sustainability including impact risk management and user engagement
fast and simple biomarker detection by computational microscopy

detection of low concentrations of biomarkers such as lowabundant proteins in physiological samples is crucial for earlystage diagnosis and disease monitoring however existing detection methods are often laborious costly and time consuming rendering them unsuitable for such applications based on advances in computational psf engineering microscopy made during our erc starting grant and in combination with microfluidic design we developed a simple and fast biomarker detection method which allows accurate and sensitive results with minimal handson sample processing which we have validated for potential applicability in diagnostics and specifically for continuous monitoring as a target clinical application towards which we can optimize our engineering efforts we demonstrate the potential for preventative diagnostics via a collaboration with rambam medical center israel focusing on monitoring cellbased cancer treatments while cellbased therapies can be highly effective they have introduced new types of cytokinerelated adverse effects that can be debilitating and even life threatening due to the current lack of appropriate diagnostics for preventative treatment these adverse effects are mitigated only when symptoms arise which might be too late we hypothesize that earlier detection using our method will enable preventive treatment and reduction in frequency and severity of these adverse events transforming patient outcome we will develop a multiplexed cytokine detection scheme that reaches clinically significant sensitivity and assess the effectiveness of this approach by monitoring cart patients in the duration of the project we will conduct a market research and develop regulation strategy with the aid of industrial and medical collaborations advancing our diagnostic method toward commercialization
precise rapid and scalable proteomics solutions for archaeology ecology wildlife forensics and foodchain authentication

taxonomic identification of tiny organic samples using proteins proteomics has major but only partially realised potential in archaeology ecology wildlife forensics and foodchain authentication it is a costeffective and minimally destructive alternative to dna analysis that can be applied even when dna is not preserved however the most widespread method known as zooarchaeology by mass spectrometry zooms or peptide mass fingerprinting cannot differentiate some taxa of major historical and ecological significance contaminated and mixed samples are also poorly resolved by zooms yet existing alternative methods are comparatively slow and expensive even when optimised the precise project will develop a new proteomics approach to taxonomic identification that is fast cheap precise reliable and realistically scalable to sample batches of varying size the method will combine the speed and simplicity of zooms with the discriminating power of more complex techniques it will immediately solve archaeological and ecological problems extending to wildlife forensics in the case of endangered species through the implementation of a research and commercial service at the national laboratory for age determination in trondheim moreover by transferring innovations to industrial partners environmental agencies and public health organisations it will ultimately provide an alternative for quick and inexpensive supplychain verification of aquaculture and livestock feeds in order to exclude species that may be unsustainably sourced eg in fishmeal or potentially harmful eg ruminant byproducts applications of the innovation will range from archaeological discoveries to revealing the past and present sustainability of life in the oceans to enhancing global food security and public health