Dragon09/odtu_chatbot huggingface dataset:
youth coproduction for sustainable engagement and empowerment in health

most traditional youth mental health interventions fail to achieve sustainable impact at scale because they overly rely on individualized medical illnessfocused models and treat youth as passive beneficiaries citiesrise a multistakeholder initiative founded in 2017 to address these gaps has worked with youth communities and professionals across five cities as well as social innovators in over twenty countries to develop a set of evidencebased scalable youth mental health interventions and implementation models the yipee project aims to provide robust evidence on the feasibility adaptability effectiveness and costeffectiveness of a multicomponent intervention targeting the inner social and environmental dimensions that underpin mental health and broader ncd risk reduction outcomes when implemented using a youthinformed and activated approach this will be achieved through a a mixedmethods approach conducting a realist evaluation across the four sites chennai india nairobi kenya cape town south africa stockholm sweden to study key implementation outcomes following the practical robust implementation and sustainability model prism as well as the mechanisms underlying why the intervention works for whom and under what realworld conditions in chennai yipee will conduct a randomized controlled trial for more robust evaluation of effectiveness and costeffectiveness in achieving key mental health and other ncd related lifestyle behavioral outcomesyipee focuses on the combination of a schoolbased multicomponent intervention targeting positive disruption in the inner social and environmental dimensions of adolescents mental health and a youthinformed and activated implementation model that puts young people at the centre of transformation working collaboratively with a range of other stakeholders
deciphering the role of host immunity in development of herpes virus meningitis

viral infection remains a major health burden globally particularly considering the recent emerging viruses the reason why individuals differ in susceptibility to viral infection is an essential still unresolved question in infection immunology research the answer has strong impact on understanding of fundamental immunological principles as well as clinical medicinein this project we aim to identify novel inborn errors of immunity conferring increased susceptibility to recurrent lymphocytic mollarets meningitis caused by herpes simplex virus 2 by using advanced methodological approaches including whole exome sequencing genome editing and diseasemimicking model systems we will search for key mechanisms of importance for antiviral defense this project will provide new insights that can be translated into early genetic diagnosis prophylaxis and gene therapy and may pave the way for development of new antiviral therapies
providing a digital and modular ecosystem for personalized capabilities development to enhance labour market participation and employment transition

the main goal of diamond is to guide individuals from vulnerable socioeconomic backgrounds on their pathway to employment by tailoring learning programmes to individual needs and bolstering employability this is achieved by developing two unique solutions 1 the employability growth index egrow index a comprehensive taxonomy of individuals employability growth including their empowerment and transformative digital green capabilities objective 1 the egrow index will act as a measurement tool for classification and segmentation of user groups regarding the content and format of learning programmes 2 the modular and versatile platform for engagement and employability move a digital platform for lifelong learning with personcentered microcredentials and learning formats objective 2 on move individuals can grow their employability based on egrow and skill forecasts by participating in concise skill programmes recommended by an aisupported system to benchmark the impact breadth of the egrow index and move econometric costbenefit analyses and a stochastic lifecycle model are applied objective 3 the objectives are enabled by a vibrant research and innovation environment the grassroot living lab stateof the art social innovation experiments iterative research and stakeholder integrated cocreation will validate the diamond solutions diamond targets directly the main impact goals associated with the call the egrow index will help individuals to assess their employability growth and to empower them to selfmanage their skill development on move the increased engagement due to tailored learning programmes will facilitate an increased labour market participation the economic analyses and model provide an improved understanding of macroeconomic effects diamond contributes to inclusive growth reduced vulnerabilities and strengthened economic resilience due to its personcentered and datatechnology driven grassroot approach
empowering the central and eastern european countries to develop circular bioeconomy strategies and action plans

cee2act will empower countries in central eastern europe and beyond bulgaria croatia czech republic greece hungary poland romania serbia slovakia and slovenia cee2act target countries to develop circular bioeconomy strategies and action plans through knowledge transfer and innovative governance models enabling sustainability and resilience to achieve better informed decisionmaking processes societal engagement and innovation building on the practice of experienced countries serving as role models in this context austria germany the netherlands belgium spain finland sweden knowledge transfer and inspiration in creative formats that address the motivations needs and knowledge gaps of each cee2act target country will be realized through the cee2act national bioeconomy hubs a participatory nonpolitical bottomup approach will be applied throughout the project activities tackling specific knowledge gaps and shortcomings of the topdown conventional approach building closer interconnections between actors across public institutions private sector industry energy smes feedstock providers eg waste side streams farmers foresters fishermen academia and research ngos csos in the target countries to achieve this a baseline assessment will be carried out socioeconomic and environmental aspects stakeholder engagement activities will be implemented ensuring the proper involvement and active participation of all relevant stakeholders digital solutions for sustainable governance will be created exchange of knowhow and best practices on technology transfer building the capacities of the stakeholders to develop bioeconomy strategies the findings will be synthetized in an analytical framework which will result in nationallevel roadmaps for the bioeconomy strategies in targeted cee2act countries boosting societal engagement in the countries transition towards circular bioeconomy
ultrafast control of magnetism with twisted plasmons

harnessing twisted light light carrying orbital angular momentum on the nanoscale and its interaction with magnetism can revolutionize how we encode and process information in fact twisted electromagnetic fields can enable a superior control over the motion of the electrons and their spin compared to circularly polarized light yet a clear demonstration that it is possible to act on magnetism using twisted light has still to be established the main challenge is to find an approach to generate nanoscale electromagnetic fields carrying orbital angular momentum which can be exploited to drive magnetism with extreme few nanometers spatial resolution at the intrinsic time scale few tens of femtoseconds of the fundamental magnetic interactions exchange and spinorbit coupling responsible for the magnetic order in matter this feature is essential for the development of ultrafast optomagnetic applications in spintronics where a major goal is the coherent control of nanoscale magnetic bits in magnetictwist i tackle this challenge and propose the way towards nanoscale control of ultrafast magnetic phenomena by exploiting twisted plasmons that is plasmon polaritons lightinduced coherent collective oscillations of free electrons in metals carrying orbital angular momentum and driven by femtosecond light pulses this strategy will enable a coherent transfer of orbital angular momentum to the electronic spin and orbital degrees of freedom at the nanoscale in this way i will disclose new types of lightmatter interactions and new kinds of optomagnetic effects with a groundbreaking impact on ultrafast magnetism spintronics and lightdriven electronics beyond this magnetictwist will open a radically new path enabling to store and process an infinite amount of information on different spatiotemporal levels impacting also other research fields such as cryptography artificial intelligence and quantum technology
affective polarization and democratic attitudes

we currently witness democratic backsliding around the world where political rights civil liberties and free and fair elections are under assault at the same time politics in many countries are increasingly characterized by hostility and distrust across partisan lines a phenomenon called affective polarization could there be a causal link between the two despite several theoretical conjectures about how affective polarization erodes democracy through its negative effects on citizens democratic attitudes we lack the evidence to support them we also do not have reliable interventions to reduce affective polarization that are generalizable to different contextsdepolarize addresses these puzzles around affective polarization with two objectives first it will identify reliable and generalizable experimental interventions to reduce affective polarization in multiple contexts second it will establish any causal relationship between affective polarization and changes in democratic attitudes through novel empirical approachesdepolarize will achieve these goals by producing and analysing highquality observational and experimental data from multiple waves of surveys in hungary poland turkey and the us these countries are selected for analyses because they have recently experienced democratic backsliding to different degrees and they are also examples of high levels of affective polarization in societythe stakes for identifying factors contributing to democratic backsliding could not be any higher depolarize will contribute to this effort by establishing whether affective polarization is a factor driving democratic backsliding using stateoftheart causal inference methods depolarize is also one of the first projects in political science to employ comprehensive measures for cumulative learning coordinated and comparable randomized controlled trials in multiple contexts with preregistration of experimental interventions
financing for green transition

as the signals of an ecological and climate crisis are intensifying the surface temperature of our planet is already around 12c above pre industrial levels and is warming at an alarming rate against this researchers at the international panel on climate change ipcc share with us their assessments that meeting the 15c target is possible and yet it will require deep emissions reductions and rapid farreaching and unprecedented changes in all aspects of society the international energy agency calls to double the pace of energy efficiency progress towards green transition and notes that large scale financing mechanisms ought to be enacted often alluded as a tragedy of horizon climate change related risks had been regarded as the problems of long dure to be tackled by future generations leaving little motivation for the current cohorts but this is no longer the case as the urgency of the anthropogenic climate crisis becomes more explicit greening of the global financial system steps ahead in our agenda central banks being no exception in fact pathways to a net zero emissions global economy are relatively wellstudied and understood yet many of these studies focused mostly on green transition of the power sector and decarbonization of the industry while financing of this transition and particularly the potential role of the central banks is a relatively neglected area in the design of the green policy infrastructure thus there is clearly an unavoidable need to deepen our knowledge on the design of a green central bank that is in the words of dikau volz 2018 a central bank that takes environmental risks including climate change into consideration in its actions it is the purpose of this research consortium to study the potential of greening of the monetary policy instruments and set the stage for a new policy environment conducive to the struggle against climate change
converting organic waste into sustainable biobased components

waste2biocomp project aims to demonstrate relevant scale production of biobased products and materials as alternatives to traditional materials with high environmental footprint using innovative manufacturing technologies the project integrates all stages in the biobased products life cycle starting from ri activities regarding the sourcing of feedstocks for the development of biobased precursors and intermediate materials smart inkjet printing techniques and smart manufacturing technologies for final products and the final demonstrators which will entail the production on a relevant scale of the following biobased products shoe sole materials with different hardness threelayered shoe insoles plastic filmspackaging with different flexibilities social face masks fashion garments printed with biobased inks leather and textile shoes printed with biobased inks paper for packaging printed with biobased inks waste2biocomp will also develop sustainability and toxicity assessments to the developed materials and products as well as remanufacturing and recycling approaches to ensure circularity by closing the material loop furthermore the project will develop dedicated training activities to support the creation of a skilled workforce in biomaterialbased manufacturing sectors particularly for the textile footwear and packaging activitiestherefore waste2biocomp will have a significative impact on the reduction of the use of fossilbased materials not only in the approached three value chains textiles packaging and footwear which are highly resource and polluting intensive sectors but also with potential for several other sectors and applicationsthe project will run for 36 months and it will be constituted by 13 partners from france germany italy portugal spain and switzerland
live biotherapeutics to potentiate cancer immunotherapy

immunotherapy including immune checkpoint inhibitors icis has revolutionized the treatment of multiple cancers antitumor responses are often durable but overall only a subset of patients receiving icis has exhibited sustained tumor shrinkage whereas a substantial fraction receiving these therapies develops immunerelated adverse events the absence of dramatic responses is attributed to several factors including abnormalities in the tumor microenvironment tme specifically many tumors such as subsets of colorectal breast and pancreatic cancer become stiff as they grow tumor stiffening causes compression of intratumor blood vessels impairing blood flowperfusion and oxygen supply hypoperfusion reduces icis delivery to the tumor and hypoxia induces immunosuppression compromising immunotherapy to restore these abnormalities a novel therapeutic strategy to normalize tumor stiffness prior to icis has been tested in preclinical studies and in the clinic this strategy repurposes clinically approved drugs to target the factors contributing to tumor stiffening leading to a new class of therapeutics known as mechanotherapeutics however drugrepurposing poses certain limitations as adding a new drug to the treatment regimen of patients with cancer is not feasible in many cases as an alternative to these approaches we propose here to test the ability of engineered live biotherapeutics in the form of programmable bacteria that offer unique advantages for delivering enzymes to normalize the tme even a small fraction of bacterial dose reaching the tumor is sufficient to colonize it and allow therapeutic concentrations of tumorremodeling enzymes to be maintained for a long period of time we propose to evaluate the ability of a novel live biotherapeutic product to improve perfusion and potentiate icis in preclinical tumor models of colorectal and breast tumors this bacterial product has great potential for commercialization and a plan is proposed
predict providing effective longitudinal models of ras direct inhibition to combat tumor resistance

problemin 2022 more than half a million lung cancer patients worldwide carrying kras mutations faced therapy resistance a trend on the rise such cancers resist standard treatments and targeted therapies leading to an average survival of 12 years posttreatment the heterogeneous genetic background of krasdriven cancer adds further complexity hindering personalized treatment due to resistance unpredictabilitysolutionour proof of concept poc project predict provides a personalized treatment roadmap for krasmutant lung cancer available through knowledge and genetic tools generated thanks to our erc cog grant karma which was aimed at the understanding of the molecular mechanisms regulating the formation of the functional kras complex at the cell membrane using geneticallydefined krasmutant cell lines our lab can facilitate direct comparisons of rastargeted treatments including approved and trial drugs this effort will empower clinicians to recommend effective strategies based on a patients specific kras mutation accounting for initial and potential acquired mutations andor mechanisms of resistance the model will evolve through in vitro testing analyzing resistance mechanisms and predicting therapies based on the patients mutational landscape importantly our approach eliminates the need for animal models
spatially resolved singlecell approaches in haematologic malignancies

a global understanding of therapy response and therapy resistance in haematologic malignancies including multiple myeloma and acute lymphoblastic leukaemia in which cancerous cells accumulate in the bone marrow is still lacking this is due to the complex nature of the bone marrow therefore the goal of sesahme is to determine the difference of the bone marrow microenvironment in healthy individuals and patients suffering from multiple myeloma and acute lymphoblastic leukaemia this will help to understand under which conditions cancerous cells can accumulate and proliferate in the bone marrow which could lead to advanced immunotherapy approaches in the futureto achieve this the objectives of sesahme are to 1 establish a method that allows to determine the immune microenvironment composition in human formalinfixed paraffinembedded samples of the bone marrow which has the potential for highthroughput screening and being cost effective at the same time and 2 to use this method to characterise a healthy and dysfunctional bone marrow microenvironment that can contribute to multiple myelomaacute lymphoblastic leukaemia development and progressionsesahme will allow the fellow to independently carry out a project which will set the ground to build upon an own individual research profile to eventually become an independent researcher key transferable training will further improve the employability and career prospects of the fellow as well as increase the fellows communication abilities the host offers a multidisciplinary environment that is well connected with experts in the field enabling the fellow to develop a new mindset and approaches the fellow brings international and specialised wetlab experience that will facilitate knowledge exchange and increase ri capacity finally sesahme will increase the global attractiveness of the host via concrete dissemination activities
community identity and diversity in german youth radio

in times of increased mobility urbanisation and sociocultural tensions the way professional media as information providers and public watchdog present diversity has implications for social cohesion and for how young people perceive identity and society against this background youth radio stations which have become increasingly interactive and collaborative in the digital age are an important point of orientation for many young people living in ethnically and linguistically diverse spaces often struggling to fit in and looking for reliable information and guidance despite german broadcasters statutory and moral obligations to promote social cohesion and to contribute to building a nondiscriminatory society in germany the medias representations of ethnic diversity have frequently been criticised little is known however about what a meaningful engagement with diversity means for journalists and how they try to create social cohesion through their work through linguistic ethnography at a german youth radio station and a critical discourse analysis of media messages cidora will provide new insights into the linguistic and semiotic practices of radio content production to explore how journalists construct and negotiate a collective urban youth identity with their diverse audience and thereby try to create a sense of community in this context my project will shed light on possible issues that can lead to an unbalanced and negative portrayal of ethnic and linguistic diversity on youth radio to foster a more meaningful engagement of journalists with diversity by developing approaches for diversityoriented communication cidora responds to timely social concerns around difference and voice in a mobile world fraught with deepening division the results of my project will be disseminated through academic publications and outreach activities for journalists organised in collaboration with media stakeholders
technological innovations in costume practice ticp enabling the adoption of new manufacturing technologies by live performance costume professionals

the production of stage costumes relies on the talents and expertise of diverse costume professionals these practitioners employ a range of tools and technologies as they collaboratively work to convert an idea or 2d sketch into a 3d garment custommade for that character and show industry 40 manufacturing technologies such as virtual patternmaking and 3d printing offer substantial productivity financial sustainability and creativity benefits to costume construction but the adoption of such technologies is haphazard and obstructed by a perception that costume practice is not technically innovative this perception is informed by systematic gender biases that limit investment in and recognition of the skills and creativity of costume professionals who are predominantly female technological innovations in costume practice ticp is a research justice project that investigates the integration of technological innovations with the aim of facilitating their adoption and application in the work of costume makers this will elevate the field of costume production and strengthen the future employability of professional costumers the central research question driving the project is as costume practitioners implement new manufacturing technologies in their workflow what are the structural and attitudinal factors that constrain and facilitate their adoption through a groundbreaking crossdisciplinary approach that applies theories about sociotechnical change to data from practitioner interviews and digital ethnography the project will develop a model of technological adoption for costume that responds to the very specific context of the live performance industry such a model will enable practitioners to be more deliberate effective and empowered when engaging with new manufacturing technologies the project results will centre the feminised area of costume at the cutting edge of a currently very malegendered technical production research discourse