Dragon09/odtu_chatbot huggingface dataset:
artificial intelligenceenabled microfluidic analysis of ciliary beat defects for drug discovery biomedicine and disease screening

in ai4cilia artificial intelligence for cilia we will develop an automated microfluidic aipowered assay of ciliated cells to detect and classify ciliary beat abnormalities for drug discovery biomedicine and disease screening rhythmically beating ciliated cells perform important physiological functions in the airways and the reproductive system defects of ciliary beat contribute to debilitating diseases such as todate uncurable chronic obstructive pulmonary disease copd and underdiagnosed causes of infertility in the context of our erc stg meccopd we recently showed that standard videomicroscopy recordings of ciliary beat can be used to extract quantitative metrics that clearly identify diseasespecific ciliary dysfunction therefore since ciliary beat can be observed in vitro and in minimally invasive biopsies it could provide a muchneeded readout for drug development and improved diagnosis however since ciliary beat patterns are highly complex it takes specialists to analyze them and hence this information is rarely exploited in praxis to establish ciliary beat as a common readout we developed a microfluidic platform that standardizes data acquisition from ciliated cells and uses ai for detecting and classifying ciliary beat defects to bring this approach to the next level and towards market entry we will address three key objectives in ai4cilia to demonstrate 1 hardware feasibility by validating human ciliated cell capture and data acquisition in our microfluidic chip 2 software feasibility by training our ai algorithm to detect diseasespecific ciliary defects and validate sensitivity and specificity of our assay and 3 business feasibility by assessing customer needs in biomedical and clinical research to define the most efficient gotomarket strategy we believe this strategy will make ciliary beat a highly sensitive and robust readout for respiratory and reproductive dysfunction in biomedical and clinical research
consortium for developing regulatory capacity for clinical trials using gene therapy products and strengthening pharmacovigilance in the conduct of clinical trials in east africa

gene therapy advancements have shown promise in treating chronic conditions like hiv and sickle cell anaemia and have the potential to greatly reduce the burden of disease in subsaharan africa which is plagued with a double burden of communicable and noncommunicable diseases these treatments have the potential to reduce the burden of disease for the populations for which they are targeted and the cost of treatments for governments in subsaharan africa there are largely no or unclear regulatory frameworks for clinical trials using gene therapy products as pioneers setting up frameworks for regulatory oversight of clinical trials using gene and cellbased therapy products uganda and tanzania will be able to share this knowledge through regional platforms to support other countries in the region to put in place similar regulatory frameworks additionally researcher workshops and course developed on gene therapy products will build capacity among researcher regulators and the publicpharmacovigilance in clinical trials for safety of trial participants and to accurately characterize the safety profile of the drug for the targeted patient population safety monitoring in clinical trials in the region currently faces challenges associated with health system challenges investigator awareness poverty and limited access to diagnostic tools additionally there is limited investigator awareness of of their responsibility to the patients with regard to monitoring and treating and accurate reporting of serious adverse events during clinical trials the results of this project will also provide a basis to sensitize investigatorssponsors and engage policymakers on the requisite health systems reforms to create a safe environment for the conduct of clinical trials with the ultimate goal of accelerating research registration and access to these new medicine technologies
against prostheses abandonment immersive and lowcost platform for the rehabilitation of upperlimb amputees

up to 44 is the abandonment rate of upperlimb prostheses the lack of training and rehabilitation is among the reasons underlying the high rejection rate when available traditional treatments lead to ineffective results because they are repetitive tedious and discouraging when considering the eu investments in prosthetic development 1735 million period 20192022 and the costs granted by the national health system for assistance this problem gets worse brainmade proposes a paradigm shift to change the current situation within the ercfunded handmade project we exploit the idea that natural hand usage shapes behavior and brain activity we reinforced the conviction that longterm continuous specialized training is prodromal for prosthesis acceptance by integrating virtual reality vr scenarios controlled by electromyographic emg activity in upperlimb amputees our experimental data on a 4week long motor training show high motor performance and embodiment even of nonanthropomorphic prosthesis eg tweezers beyond being highly specialized as it contains the hand degrees of freedom we realized that this virtual bionic tool simplifies action intention and execution by exploiting motor properties hardwired in the brain thus the difficult transition toward prosthesis acceptance may imply a progressive acquisition of new motor skills and adopting brainmade prosthetic devices built on an individuals expertise and neural resources the proposed motor training protocol also integrates fullycustomized inkjetprinted and lowcost emg sensors designed on the patients stump and residual muscle activity and daily monitoring of the motor performance those data will serve prosthesis fabrication and feed freelyavailable databases for developers in the rd sectors of upperlimb prostheses with the ultimate project goal of reducing prosthesis abandonment our idea can significantly impact amputees lives and transform rehabilitation practice
the gibbs framework for nearterm quantum computing

the gifneq project one of the major bottlenecks in quantum computing noise an umbrella term for various imperfections affecting the device the initiative establishes a unified theoretical framework focusing on two primary goals developing scalable noise characterization techniques and crafting verifiable quantum algorithms resilient to substantial noise levels a particular focus is placed on revolutionizing dissipative preparation schemesa subset of quantum algorithms analogous to metropolis samplingaiming to make them a preferred state preparation method by creating noiseaware verifiable algorithms requiring considerably less quantum error correction a resourceintensive element in quantum computingsimultaneously gifneq endeavors to radically simplify and augment the reliability of the traditionally complex noise characterization process it leans on recent breakthroughs in robust learning theory to discern and detail structured noise sources efficiently introducing protocols resilient to anomalies ensures robust and reliable learning of quantum noise these objectives are intertwined by the requisite mathematical framework heavily contingent upon quantum gibbs states a quantum extension of markov random fields with the project also seeking to obtain various mathematical statements related to these statesgifneq promises to be a watershed in quantum computing targeting practical resolutions with profound theoretical insights and bridging domains like quantum information computer science and mathematical physics to pave the way for breakthroughs that reshape the effective utilization of quantum devices as a seasoned expert in the field with a wealth of knowledge on noise impact characterization and quantum dissipation in quantum computation substantiated by publications in renowned journals such as nature physics or nature communications i present a uniquely qualified leadership to steer this transformative project
next generation ketoamide inhibitors of fibroblast activation protein fap to revolutionize radionuclide therapy in cancer

fibroblast activation protein fap is a serine protease that is highly expressed on cancerassociatedfibroblasts cafs in nearly all tumor types its limited presence in healthy tissues makes it an attractive diagnostic and therapeutic biomarker for cancer uamc1110 a potent and specific fap inhibitor discovered by the host opened the way for the development of the socalled fapis these are tumortargeting molecules composed of a uamc1110 moiety and a radionuclide the latter can either be a diagnostic radionuclide for pet imaging or a more cytotoxic radionuclide for cancer therapy radiodiagnostic fapis are now entering clinical practice but their therapeutic counterparts face challenges related to the relatively short tumor residence time of currently available molecules the latter leads to significant leaking of toxic radioactivity from the tumor to overcome this issue we will develop ketofapis that form longlived covalent bonds with fap this should already ensure significantly longer tumor residence the ketofapis will also be bound to the surface of gold nanoparticles aunps the resulting constructs could have further increased tumor residence through the multivalency effect this interdisciplinary proposal covers 1 the chemical preparation of novel ketofapis and derived aunps 2 their in vitro characterization and 3 in vivo investigation in a mouse model of colorectal cancer overall the project can lead to safer and more efficient fapis for radiotherapy applications the status of fap as a pancancer biomarker entails that these fapis could be applied in nearly all cancer types
predicting fracture in 3d printed concrete beam lattice systems with the quasicontinuum method for computational efficiency

3dprinted concrete 3dpc mitigates co2 emissions provides architectural design with higher degrees of freedom and decreases both labor costs and energy consumption however its layerbylayer buildup process results in weaker and more porous interlayers thereby significantly decreasing the integrity and durability of 3dpc structures and limiting the versatility of this technology to overcome this major drawback fraqcon aims to develop a computationally efficient framework to understand how porosity affects interlayer bond strength and to enhance 3dpc for this purpose fraqcon will apply numerical beam lattice models to 3dpc because they accurately predict fracture in heterogeneous materials such as concrete and rock although microscale porosity analysis based on simulations of engineeringsized 3dpc structures remains computationally unfeasible the multiscale quasicontinuum qc method has efficiently reduced computational costs for lattice systems its current form is not yet applicable to 3dpc beam lattices but fraqcon will develop a novel qc methodology for fracture in 3dpc beam lattice models to predict failure in a computationally feasible way while accounting for porosity on a microscale and accurately representing the complex air void morphology in 3dpc interlayers moreover this qc methodology will be validated with experimental tests by identifying key parameters that cause interlayer weakness fraqcon will significantly improve 3dpc technologies and increase the integrity safety and durability of 3dpc structures the fraqcon qc framework and the knowledge gained during this project will be transferred to a 3dpc startup in a nonacademic placement to accelerate the adoption and foster the market impact of this technology therefore fraqcon will not only demonstrate the applicability of the qc method for 3dpc design but may also transform the construction sector towards automation
electric vehicles fire risk assessment in indoor car parks

the sales share of electric vehicles ev in europe rose to 10 in 2020 as compared to 32 in 2019 this trend is projected to increase to 19 in 2025 and 35 in 2030 this positive trend comes with the safety risk and hazards associated with evs the current immediate need of research must be concentrated for indoor car parks due to its comparatively higher risk than any other open spaces to date there is no specific study on ev fire safety in car parks which is concerning given that the number of ev fleets are growing at a rapid pace in europe with past incidents of burning ev vehicles related to the charging process as well as with the ongoing battery fire safety issues there is an urgent need to explore in detail within the topic of ev fire safety in car parks recent searches from building codes from germany netherlands norway spain and austria have concluded that there are no specific fire safety design regulations for evs in car parks responding to this research and policy gap this interdisciplinary project aims to develop a stateoftheart risk assessment model that can be used to quantitatively measure the risk of ev fire in indoor car parks to achieve the aim two main objectives have to be fulfilled o1 to establish a qualitative and quantitative fire risk assessment model that can be used to measure risk level of specific car park design o2 to propose prevention and mitigation measures in a selected architectural design of car parks to accomplish the objectives activities such engagements assessments and simulation work are planned within the 5 work packages proposed in the project the output from the assessment can be used to develop specific prevention and mitigation measures for specific car park design that can lead to minimization of the impact of ev fire the model can also be used as a baseline to develop a policy or regulation for authorities having jurisdiction
selfhealing screenprinted perovskite photovoltaics beyond shockleyqueisser limit

due to environmental benefits scalability competitive cost and limited maintenance photovoltaic pv systems are the fastestgrowing renewable energy technology enabling largescale carbonfree electricity production within the family of pv systems metal halide perovskite mhps solar cells are the most performant at converting sunlight to electricity due to their excellent optoelectronic properties and cheap fabrication process mhp based on hybrid organicinorganic lead halides are the most effective perovskite solar cells yet there are two major challenges to widespread adoption of lead based lhp pv i instability especially against moisture and ii high level of lead pb and lead leakage which are toxic to humans and wildlife according to eus restriction of hazardous substances rohs directive this proposal will develop for the firsttime perovskite photovoltaics with selfhealing capabilities while decreasing lead leakage to near zero by transferring the microconcentrator pv concept to mhp such a configuration enables to save 90 to 99 raw materials compared to a planar device more importantly it increases the theorical efficiency and reduces the pb content and leakage so the main goal of this proposal is to boost the stability of lead halide perovskite pv systems by introducing microconentrator pv concept and concentrated light to mhp in addition to taking advantages of microconcentrator pv ie physical separation and embedding of each microcell to enable the pv system to theoretically exceed the shockleyqueisser limit and reduce toxic lead levels to below rohs requirements sherpas achievements will make advancements on cutting edge mhp solar cells that are pivotal to reach eus environmental targets for a reliable and green energy transition at lowcost
euroheartpath leading innovation in cardiovascular pathways for improved patient outcomes

cardiovascular diseases cvd present a significant public health challenge throughout europe being the leading cause of morbidity and a major contributor to mortality despite technological advancements and preventative strategies the burden of cvd remains substantial and the cardiac care pathways across europe are inadequately mapped the overarching goal of the euroheartpath consortium is to transform cardiovascular care pathways across the continuum of care by adopting a paneuropean scope and facilitating crosscountry comparisons euroheartpath aims to elucidate how care is organized and delivered providing deeper insights and identifying best practices for integration with the support of stakeholders including esc wonca eupha and epaeuroheartpath will simultaneously conduct 18 pathfinder studies to optimize the personalized early detection diagnosis monitoring and treatment of heart failure atrial fibrillation ventricular fibrillation and coronary disease with a particular emphasis on prevention these studies are categorized into four key areas 1 novel artificial intelligence ai and machine learning applications such as automated ai analysis of ecgs and holters and ai for predicting cardiomyopathies and cardiovascular events 2 digital health integration aimed at improving the diagnosis of aortic stenosis and enhancing secondary prevention measures 3 pointofcare testing including the use of pointofcare diagnostics in primary practice and ambulances to exclude heart failure and 4 technology and robotics encompassing robotic echocardiography and invasive diagnostics in obstructive epicardial coronary artery diseaseeuroheartpath will create a paradigm shift in the management and treatment of heart disease offering substantial scientific societal and economic impacts across the entire patient health journey with a patient centric approach
boosting the exploitation of standardisation inputs from european projects

contributions from industry research and endusers involving experts that represent diverse stakeholders are crucial for the standardisation development however the standardsmaking process and rules are sometimes at odds with the culture and practice of research stand4eu aims to strengthen the links between research innovation and standardisation ensuring that standardisation is an integral part of the european research and innovation landscape stand4eu will map and identify key stakeholders and actors involved in standardisation activities at national regional eu and international level to allow a proper identification of the obstacles hampering the standardisation efforts within the scope of 4 main technological domains additive manufacturing welding smart manufacturingindustry 40digitalization artificial intelligence circular economythe key bottlenecks in the standards development lifecycle will be identified and to overcome the obstacles on the standards setting process a plan will be develop with recommendations and solutions to make the standards development process more efficient between the stakeholders from research innovation and standardisation a stand4eu interface will be created to facilitate the collection and the sharing of information about the obstacles and associated remedies and best practices towards the industrial and research innovation community the standards developing organisations the public authorities and other relevant stakeholders this will include pointers to available supporting services networking services herewith acting as a onestopshop for all related standardisation research and innovation mattersall the proposed solutions will be validated with the relevant actors and stakeholders to transfer the methodology to a broader scale of application in other respective areas to reach sustainable development of developed methodological approach and exploit the stand4eu interface globally
inducing functionality in retinal organoids with electrical activities derived from developing retina

deriving mammalian retina from stem cells has had a large impact on the study of the biology of vision and is called organoid compared to in vivo retina retinal organoids are far less functionally sophisticated in terms of their synapses connectivity discrimination between different light stimuli and their electrical action potentials this project will overcome this functional constraint of retinal organoids by studying electrophysiological eventsderived functional maturation of mouse retina during retinal development and then stimulating those events with the help of mathematical models in order to induce the same functionality in mouse and human retinal organoids neufro will achieve a resonance in the field by generating retinal organoids with the neuronal connectivity and the natural diversity of functions using interdisciplinary fields including electrophysiology developmental biology and computationallyderived electrical stimulation initially i will create a holistic roadmap of the electrical features of immature mouse retina during development that shows selforganization through electrophysiology with milli to nanometer imaging precision electrical activities derived the circuit formation will be spatiotemporally documented then i will decode this spacetime code of intrinsic electrical patterns and neuronal connectivity using an ambitious strategy incorporating hodgkinhuxley and linearnonlinear models next such electrical response models will be applied to immature retinal organoids mouse and human by an innovative sandwich electrophysiology technique during the development in vitro with this approach i will induce naturalistic electrical features in the retinal organoid allowing the functional neurons to wire and fire appropriately into retinal organoids particularly visual circuits this groundbreaking approach will advance techniques for generating functional human retina
lineup longitudinal data for inequalities in education

lineup aims at identifying key success factors for quality education for all by mapping and analysing the research design and findings of existing longitudinal data on students learning outcomes at primary and secondary level 618 yearold students considering that 2023 is the european year of skills and in line with the objectives of the european education area and council recommendation on pathways to school success the project focuses on achievement and attainment of basic skills lineup is based on a comprehensive desk research aiming at collecting analysing and summarizing data that allow assessing inequalities in education over time in 31 countries and with a particular focus on southern and western europe part of the activities are dedicated to understand to what extent different databases can be made directly comparable and deliver a feasibility study that brings innovation to the research community interested in comparative longitudinal analysis a qualitative research in project countries complements the mapping to gather primary data on the implementation process and impact of possible compensatory interventions in line with the findings of recent longitudinal studies the objective is to further investigate what schools can do to keep their students engaged meet their characteristics and needs and reduce inequalities in the short medium and long run lineup will contribute to expand the knowledge base on what shapes educational outcomes over time and on studentcentred interventions aiming at lifting the performance in basic skills and reducing early leaving from education and training which are a key challenge across europe attention will be dedicated to cooperating with national authorities of the participating countries to identify and access longitudinal data and other administrative sources and to validate and disseminate the results at european national and local level for a more supportive and equitable school environment