Dragon09/odtu_chatbot huggingface dataset:
stabilis providing relief for tremor patients

millions of people worldwide have trouble with involuntary shaking hands these shakes are called tremors commonly seen in parkinsons disease multiple sclerosis and essential tremor tremors lead to a lot of frustration not only does it make eating and drinking difficult or impossible but people are often ashamed current treatments to suppress tremors are often inefficient and lead to heavy side effects there is a need for a new solution stil is developing a medical device that will enable people with tremors to return to their activities of daily living the stil antitremor orthosis called stabilis uses technology that suppresses the tremor but still allows voluntary movement with its lightweight and ergonomic design patients can conveniently wear the device when they need it without the side effects that medication would give it is stils mission to provide freedom to people who suffer from tremors allowing them to comfortably live life
spatioseasonal ecoevolutionary dynamics

my overarching ambition in ecoevomove is to provide new theoretical and empirical understanding of how ecological and evolutionary dynamics can interact to rescue wild populations from impending extinctions caused by changing and increasingly extreme seasonal climatic conditionsseasonal climates are rapidly changing but capabilities to predict realworld population responses are still severely limited major problems are that 1 existing ecoevolutionary theory relies on core assumptions that are fundamentally violated by intrinsic properties of key traits that shape seasonal population dynamics and 2 key microevolutionary processes that drive interacting seasonal and spatial dynamics have not yet been quantified in any wild population we therefore have no capacity to predict how fast climateimpacted animal populations could adapt through changing seasonal movements profoundly reshaping seasonal locations and wider ecological interactionsi will provide1 new theory that identifies general principles of ecoevolutionary dynamics arising in seasonally and spatiallyvarying environments2 the first empirical estimates of complex quantitative genetic effects and feedbacks that drive microevolution and plasticity in seasonal movements and resulting spatioseasonal dynamics in natureby coupling these theoretical and empirical advances i will test the overarching hypothesis that rapid microevolution of the degree or form of seasonal movement could facilitate rapid evolutionary rescue of wild metapopulations facing changing seasonal climates preventing system collapsei will achieve these advances through new general theoretical models of complex nonlinear ecoevolutionary dynamics new widelyapplicable statistical methods for quantitative genetic analyses of spatioseasonal field data and groundbreaking application to an unprecedented largescale multigeneration dataset on a wild bird system exhibiting flexible seasonal migration
first ever preventive treatment for celiac disease and gluten sensitivity

e40 is a novel gluten degrading enzyme aimed at enhancing the degradation of ingested gluten particularly in gluten intolerant celiac disease ced and nonceliac gluten sensitivity ncgs sufferersdifferent from any other competing enzymes under development e40 efficiently exerts its gluten degrading activity in both the stomach and the intestine of ced and ncgs sufferers supporting the benefits of a gluten free diet gfd the final goal is to prevent symptomatology due to the proinflammatory reaction triggered by glutene40 will allow sufferers to manage inadvertent gluten exposure and will improve sufferers quality of life in particular allowing them to normalise their work and social life reducing anxiety and allowing them to enjoy many everyday activities like eating in a restaurant travelling and visiting their friends in their homese40 is produced by an engineered patented acidic streptomyces lividans tk24 strain and directly purified in its mature functional form e40 activity has already been confirmed using the validated human simulated digestion infogest assay of real food digestion e40 gluten degradation leads to a glutenfree status residual gluten20ppm as per ec guidelines
novel dry air switchgear technology to reduce industrys dependence on sf6

nuventura develops medium voltage mv gas insulated switchgear gis which replaces sf6 the worlds strongest greenhouse gas with dry air annual sf6 emissions are 8100 t equal to the co2 emissions by 100m cars 85 of sf6 gas is used as a gis insulating medium though recycling of sf6 is possible it is usually not done due to difficulty cost it can be expected that sf6 that exists now that is produced in the future will persist for thousands of years whether in gis equipment or ultimately in the atmosphere sf6 atmospheric lifetime is 3200 years mv power grids 12405 kv use 3 types of switchgear air insulated switchgear ais solid insulated switchgear sis gas insulated switchgear gis ais have a large physical footprint costly maintenance inability to meet the demands of urban grids sis works only in rare highly specialized use cases nuventura combines the advantages of gis ais in a new dry air switchgear that is sustainable safe reliable
advanced ingestibles for probing the nexus between gastrointestinal functions and physicalmental wellbeing in animals and humans

expanding on the ehonesty erc project about the link between body and moral decisions the deepdive poc proposal aims to explore the neglected role of deepbody signals in modulating physicalmental health in humans and animals through the radically new approach of using ingestibles for mapping gastrointestinal gi physiology crucially although the market of ingestible devices is burgeoning none of the existing products has the features needed for probing the link between gi dysfunctions and physicalmental wellbeing in humans and animals to fill this outstanding gap the deepdive project aims to develop and test a class of ingestibles that can capture from different tracts of the gi system eg stomach smalllarge intestine physiological signals like endoluminal ph pressure and temperature with unprecedented accuracy and precision and remarkably add causation to correlation by recording the gi neurons activity before and after their electrical perturbation the inert capsules will be produced by i assembling specific components created using 3d printing and ii integrating a number of microscopic components ranging from solid state ph temperature and pressure sensors to adda microconverter and rf radio 24 ghz in a subcentimetric space gi functions at rest and in conditions of social stress will be tested in piglets using the new ingestible and in humans using commercial pills all the steps towards patenting and obtaining permission for use in humans of the novel ingestible will be taken and existing contacts with industrial partners and biomedical devices approval offices will be strengthened given the link of gastroenterology with physicalmental dysfunctions and humananimal wellbeing the project will have significant benefits at neuroscientific medical and societal levels moreover since the global market of ingestible sensors is expected to exceed 14 billions by 2026 deepdive will likely have key economic implications
cohesin therapeutics precision medicine for treating stag2 mutated cancers

the cohesin gene stag2 has emerged as a new tumour suppressor frequently mutated in bladder cancer ewing sarcoma and acute myeloid leukaemia aml currently these cancers are treated by cytotoxic therapies and surgery these treatment plans are limited by unwanted side effects have not been able to eliminate the high mortality caused by aml and have not improved over the last few decades stag2 mutations are therefore a biomarker for cancer patients with high medical need we discovered that stag2 mutated cancer cells are highly vulnerable to the inactivation of another protein called stag1 while healthy cells remain unaffected this highly selective sensitivity of cancer cells towards such a treatment is exceptional and could be exploited for precision medicine our longterm aim is therefore to develop stag1 inhibitors this precision medicine would greatly decrease side effects and costs from which patients doctors and health insurance companies would benefit to enable the development of such a stag1 inhibitor exploring the innovation potential is essential for this several stepping stones need to be reached which we would like to achieve with support of this ercpoc grant 1 optimising our building blocks for a stag1 inhibitor 2 developing an intellectual property strategy 3 assessing commercial feasibility and 4 developing a business plan altogether this will result in a proposition package that can be used to present the commercial potential to strategic partners for this purpose we have assembled a team that shares the same enthusiasm to achieve our common goal to develop precision medicine for patients suffering from stag2 mutated cancer
assessing the role of intratumoral microbiota in therapy responses using patientderived tumoronchip

this action is part of the cancer mission cluster of projects on understanding tumourhost interactionschallenge primary or acquired resistance to therapies is a major challenge in oncology recent research suggests that intratumoral microbiota may contribute to anticancer drug resistance in particular to immunotherapies such as immune checkpoint inhibitors ici however experimental approaches to address the role of microbiota in human cancers are lacking solution project arturo will ethically tackle this problem by using an innovative stateoftheart 3d tumoronchip toc model as part of the emerging field of microphysiological systems mps plan the role of patientderived bacteria and of their postbiotics and released extracellular vesicles in tumor ecosystem behaviors and drug responses will be deciphered by integrating clinical data omics analysis and novel tocbased information by live imaging and singlecell transcriptomics the development of advanced computational methods to extract tocbased information constitutes a major force and innovation in the field with high potential to accelerate future applications of toc technology in clinics the focus will be on two frequent poorlyunderstood cancer subtypes nonsmall cell lung cancer nsclc and invasive lobular breast cancer ilc endusers perspectives will be addressed using a codesign approach to develop ethically sound and evidencebased cancerrelated innovation and health policiesimpact arturo results are expected to lead to a deep understanding of processes underpinning tumorhost interactions helping to conceive novel microbiotabased intervention strategies in particular for nsclc and ilc patients arturo will take social ethnical cultural and gender aspects into account facilitating the translation of arturos innovations to clinical practice and codesign of policies ultimately the arturo impacts will be farreaching contributing to future developments in cancer precision medicine and diagnostics and to the eu mission cancer
genetic code expansion for biocatalysis and enzyme engineering doctoral network

the expansion of the genetic code for the incorporation of noncanonical amino acids ncaa in proteins provides biotechnologists with an amazing kit of novel tools ncaa can be used in multiple applications such as investigation of the structure and dynamics of proteins as handles for protein imaging and spectroscopy metal chelators or as click chemistry reagents yet only a few cases exist where ncaa are used in enzyme engineering to explore improve or install new enzymatic activities further development has been restricted by the limited efficiency and flexibility of tools for their incorporation this is mainly caused by the field developing separately and not being driven by desired target catalytic activities and needs of protein engineers therefore this dn proposal aims to bridge this gap and bring experts from different fields together to ensure the development of the methodologies in a collaborative manner with a threefold training structure learnteachcreate the dn trains 10 phds at the boundaries of biocatalysis synthetic biology peptide chemistry and computational biology and brings together a team of academic and industrial partners to increase the european research capacitythe efficiency and flexibility in ncaa incorporation are decisive for successful catalytic application use of ncaa for selective protein conjugation facilitates application in siteselective immobilization combination of protein folding analyses in highthroughputscreens with automatization fosters the application of ncaa in directed evolution to engineer reactivity and stability of enzymes going a step further ncaa can provide functional groups for designed biocatalysts for newtonature reactions the proposed research affords new tools and applications and the newly designed catalysts are envisioned to be important biotechnological processes for a greener more environmentally friendly production of chemicals and pharmaceuticals
microbially induced mineralisation of wood for improved fire resistance

wood is the only renewable construction material and holds great promise for sustainable built environments of the future however its combustibility is a major limitation the drawback of using traditional fire and flame retardants is the toxicity and volatility of some of their components and the loss of chemicals by leaching leading to poorer performance mineralisation of wood offers a green alternative but current strategies often require a costly technical setup for supercritical gases or the use of harmful chemicals to achieve the deposition of minerals deep inside the wood structure biologically induced mineralisation is a widespread phenomenon occurring in all kingdoms of life in recent years microbially induced calcium carbonate caco3 precipitation has been proposed as a potential solution to address many environmental and engineering issues related to the enhancement of inorganic materials protection of concrete soil consolidation however the potential for using fungi has received relatively little attention compared to bacteria the microinsert project will investigate the feasibility of using fungi as caco3 carriers to develop a novel bioinspired mineralisation process for biobased building materials wood as a highly porous threedimensional organic scaffold will be mineralised to create hierarchically structured organicinorganic hybrid materials with novel properties including improved fire resistance the proposed bioinspired treatment incorporates ideas for sustainable materials design circularity reduction of toxicity and lowering the negative impact on the environment the microinsert project will stimulate innovation and knowledge transfer between the host and er by building a solid research network organising events mentoring young researchers and managing projects the er will gain research and scientific skills and acquire a new set of competencies to reach professional maturity and independence after the fellowship
combine measures of social assistance benefit indicators to correct for measurement error

aim to break new ground in the field of official statistics combine produces errorcorrected figures on 1 the number of individuals receiving social assistance benefit at a given point in time and 2 the transition rate out of social assistance between two points in time background social assistance benefits are an important pillar of the welfare state policy making on social assistance benefits is based on official statistics that are produced by national statistical institutes with the use of register data however register data suffer from measurement error that can severely bias official statistics and consequently policymaking that uses these statistics innovation combine tests applies and evaluates a novel modelbased errordetection and correction method on social assistance benefits this method does not require concrete knowledge of the causes of measurement error with this method we produce different and more reliable official statistics on social assistance benefits moreover this method is more efficient than the practices of dataquality improvement that national statistical institutes currently applyplan the project is carried out in collaboration with statistics netherlands and in particular with its department of demographic and socioeconomic statistics besides producing errorcorrected official statistics on social assistance benefits combine delivers an implementation plan of the method to other official statistics by statistics netherlands or other national statistical institutes and a dissemination plan for approaching policymakers and other users of the statistics impact combine will encourage a cultural shift in official statistics by boosting the confidence of national statistical institutes in producing modelbased errorcorrected statistics in the policy field as the method is applicable to a wide range of topics the project contributes to evidencebased policymaking
indopacificeuropean hub for digital partnerships trusted digital technologies for sustainable wellbeing

the mission of inpace is to actively support the implementation of the digital partnerships with japan the republic of korea and singapore and the cooperation with india in the context of the trade and technology council by creating a sustainable and interactive multistakeholder indopacific european hub the inpace hub is organised in 3 pillars policy activity cluster 1 digital dialogues policy and education rolling out digital technologies activity cluster 2 innovation and entrepreneurship for sustainable wellbeing and pushing key technologies forward clusters 3 trustworthy decision support 4 chips of the future and 5 future networks the hub will create a inpace community platform to support the implementation of digital partnerships in the indopacific a key element of inpace is to organise thematically focused discussions on the expert level in 17 areas of strategic interest in thematic working groups this will lead to detailed and strategic outputs based on analytical work and deep domain knowledge 28 events both thematic and integrated will provide networking opportunities inpace combines three levels of interventions feeding each other the expert level the government level the broader community of stakeholders inpace integrates cocreation stakeholder engagement community building particular attention is given to the impact and implications of digital technologies from the social and humanistic point of view regular communications with the ec and policy makers will ensure compatibility with ongoing efforts and priorities it will also be assured through the asian partners that the counterparts in the partner countries are informed and supportive of the activities inpace will from the start embed sustainability in the project execution aiming at the hub becoming a sustainable longterm expertdriven mechanism for euindopacific collaboration in digital technologies and possibly beyond
human centered technologies for a safer and greener european construction industry

the european construction industry faces three major challenges improve its productivity increase the safety and wellbeing of its workforce and make a shift towards a green resource efficient industry to address these challenges adequately humantech proposes a humancentered approach involving breakthrough technologies such as wearables for worker safety and support and intelligent robotic technology that can harmoniously coexist with human workers while also contributing to the green transition of the industry our aim is to achieve major advances beyond the current stateoftheart in all these technologies that can have a disruptive effect in the way construction is conducted by a new generation of highly skilled male and female construction workers and engineers working in a safe and rewarding digitally enabled environment these advances will include introduction of robotic devices equipped with vision and intelligence to enable them to navigate autonomously and safely in a highly unstructured environment collaborate with humans and dynamically update a semantic digital twin of the construction site visual information capturing will extend to multispectral imaging enabling detection of material composition of built structures besides geometric characteristics intelligent unobtrusive workers protection and support equipment ranging from exoskeletons triggered by wearable body pose and strain sensors to wearable cameras and xr glasses to provide realtime worker localisation and guidance for the efficient and accurate fulfilment of their tasks an entirely new breed of dynamic semantic digital twins dsdts of construction sites simulating in detail the current state of a construction site at geometric and semantic level based on an extended bim formulation encompassing all relevant structural and semantic dimensions bimxd bimxds will act as a common reference for all human workers engineers and autonomous machines
engineering synthetic cells for artificial phagocytosis with superselectivity

encaps will produce the first phagocytic synthetic cell capable of superselective artificial phagocytosis artificial phagocytosis aims to mimic the complex mechanisms used by cells to internalize materials in minimal engineered systems achieving a major milestone in the construction of advanced synthetic cells this endeavour faces two main challenges the energy barriers to particle internalization upon membrane bending and the lack of selectivity previous approaches using liposomes or polymersomes did not sufficiently address these two challenges since liposomes lack stability and polymersomes have rigid membranes to go beyond the stateoftheart i will use a new class of membraneforming polymers ionically linked comb polymers they selfassemble in icombisomes with high stability and flexibility providing an ideal platform for phagocytic synthetic cells by carefully designing the molecular structure and the statistic composition of the polymers i will dissect how structural variations in the molecular composition can serve to store potential energy that can be released to facilitate the engulfment subsequently i will seek to introduce principles of superselectivity to particle interactions with icombisomes achieving an onoff type response here i will unveil the interplay of binding strength receptors mobility and clustering on the membrane using supported bilayers this will be translated to freestanding icombisomes generating a superselective synthetic cell that can bind and internalize particles with specific surface decorations to demonstrate the flexibility of this approach several colloidal systems will be internalized thus encaps will yield general design principles for superselective artificial phagocytosis due to its deep interdisciplinary encaps will impact several fields providing the blueprint for new nanocarriers theragnostic devices and advanced synthetic cells